Relles, Sofia Maris G.

BSN 4A
February 19, 2023

DRUG STUDIES

Generic Name: Midazolam

Brand Name: Versed

Drug classification: Pharmacotherapeutic: Benzodiazepine

Clinical: Sedative, Anxiolytic

Image of the Drug:

Mode of action Acts at many levels of the CNS to produce generalized CNS
depression. Effects may be mediated by gamma-aminobutyric acid
(GABA), an inhibitory neurotransmitter.

Therapeutic Effects: Short-term sedation. Postoperative amnesia.

Route: PO, IV and IM

Dosage: IV: 1–5 mg/ml

IM: 1 mg/ml.
PO: 0.25–0.5 mg/kg. Max: 20 mg

Indication: PO: Preprocedural sedation and anxiolysis in pediatric patients.

IM,IV: Preoperative sedation/anxiolysis/amnesia.
IV: Provides sedation/anxiolysis/amnesia during therapeutic,
diagnostic, or radiographic procedures (conscious sedation): Aids in
the induction of anesthesia and as part of balanced anesthesia. As
a continuous infusion, it provides sedation of mechanically
ventilated patients during anesthesia or in a critical care setting,
status epilepticus.

Side Effects: Frequent (10%–4%): Decreased respiratory rate, tenderness at IM

 or IV injection site, pain during injection, oxygen desaturation,
hiccups.
Occasional (3%–2%): Hypotension, paradoxical CNS reaction.
Rare (less than 2%): Nausea, vomiting, headache, coughing

Adverse Reactions: Inadequate or excessive dosage, improper administration may

result in cerebral hypoxia, agitation, involuntary movements,
hyperactivity, combativeness. Too-rapid IV rate, excessive doses, or
single large dose increases risk of respiratory depression/arrest.
Respiratory depression/apnea may produce hypoxia, cardiac arrest.

Nursing Management: 1. Check the doctor's order and verify the patient's identity.
2. Ensure that the medication is prescribed by the physician.
3. Resuscitative equipment, oxygen must be available.
4. Obtain vital signs before administration.
5. Monitor respiratory rate, oxygen saturation continuously
during parenteral administration for underventilation, apnea.
6. vital signs, level of sedation q3– 5 min during recovery
period.
7. Monitor signs of laryngospasm and bronchospasm,
including tightness in the throat and chest, wheezing, cough,
and severe shortness of breath.
8. Assess heart rate, ECG, and heart sounds, especially during
exercise. Report any rhythm disturbances or symptoms of
increased arrhythmias, including palpitations, chest
discomfort, shortness of breath, fainting, and
fatigue/weakness.
9. Report excessive or prolonged sedation, agitation, or blurred
vision; that is, CNS symptoms that persist more than 12 hr
after the drug has been discontinued.
10. If used during mechanical ventilation, observe whether the
patient is adequately sedated and the chest wall is relaxed
and compliant with ventilation.

Source: Hodson, B.& Kizior, R. (2013, June 7). Saunders Nursing Drug Handbook. 3251

Riverport Lane St. Louis, Missouri 63043. Elsevier.