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MORRIS,

USING
HEALTHLIFE
ECONOMICS
HAMMITT
EXPECTANCY TO COMMUNICATE BENEFITS HEALTH ECONOMICS

Using Life Expectancy to


Communicate Benefits of Health Care
Programs in Contingent Valuation Studies
Jill Morris, PhD, James K. Hammitt, PhD

Background. There is growing interest in the use of contin- willingness to pay (WTP) estimates for consistency with theo-
gent valuation (CV) to estimate the monetary value of health retical predictions. Results. It is found that WTP for a longev-
program benefits. Ideally, CV could be used to value a specific ity benefit is sensitive to the framing of the benefit, with re-
shift in survival curve. However, a shift in survival curve may spondents expressing higher WTP for the benefit expressed
prove too complex for widespread use in CV instruments. To as a life expectancy gain. The life expectancy format per-
facilitate the use of CV in valuing longevity benefits, research- forms better than the risk reduction format in one important
ers need alternative summary measures that describe the lon- regard—sensitivity to scope of the benefit—and no worse
gevity benefit in a single number that is more readily commu- than the risk reduction format in other regards. Conclusion.
nicated in a CV context. Methods. The authors compare 2 Expressing longevity benefits in terms of life expectancy ap-
methods for communicating longevity benefits in a CV sur- pears to hold promise as a method for enhancing the validity
vey. Random subsamples of respondents valued a longevity of economic evaluation of health care programs. Key words:
benefit expressed either as a continuing reduction in annual risk communication; contingent valuation; life expectancy;
mortality risk or as a gain in life expectancy. To compare the willingness to pay; pneumonia vaccine. (Med Decis Making
validity of the alternative descriptions, the authors evaluate 2001;21:468–478)

1. Introduction opment of CV methods for estimating monetary values


of longevity benefits.
The rapid growth of medical technologies offers an An intervention that extends life alters the benefi-
expanding array of interventions that extend human ciary’s survival curve. Ideally, we could use CV to elicit
lives. An increasing number of preventive programs, a monetary value for the specific shift in the survival
such as environmental regulations to reduce air pollu- curve. However, a survival curve is a complex con-
tion, are also aimed at prolonging lives. Resource con- struct, and describing benefits as a shift in the survival
straints preclude implementation of all possible life- curve might prove too cognitively demanding for use in
extending opportunities and necessitate comparison of CV applications. We evaluate alternative summary
the anticipated costs and benefits of alternative inter-
ventions. Benefit-cost analysis requires credible values
Received 17 August 2000 from the Center for Risk Analysis, Harvard
of longevity benefits if it is to contribute in a meaning-
School of Public Health, Boston, Massachusetts (JM, JKH); and the
ful manner to the resource allocation debate. Centers for Disease Control and Prevention, Atlanta, Georgia (JM). Re-
There is growing interest in the use of contingent vision accepted for publication 25 June 2001. This work was sup-
valuation (CV) to estimate the monetary value of health ported by the U.S. Environmental Protection Agency (R 825312-01-0).
program benefits. CV uses surveys to elicit risk-dollar The research presented herein does not represent the opinions of the
trade-offs in hypothetical decisions. A recent review Centers for Disease Control and Prevention or the U.S. Department of
suggests that the use of CV for evaluation of health care Health and Human Services.
programs is in a developmental stage that would bene- Address correspondence and reprint requests to Dr. Morris: Centers
fit from research to enhance the validity of the meth- for Disease Control and Prevention, 4770 Buford Highway NE, MS K-
ods.1 We offer this study as a contribution to the devel- 28, Atlanta, GA 30341-3724; telephone: (770) 488-3262; e-mail:
jmorris1@cdc.gov.

468 · MEDICAL DECISION MAKING/NOV–DEC 2001


USING LIFE EXPECTANCY TO COMMUNICATE BENEFITS

measures that collapse the information into a single CV. We compare 2 methods of expressing a life exten-
number that can be more easily communicated. sion benefit by asking half of a random sample to value
A variety of summary measures may be used in lieu a life extension benefit expressed as a continuing re-
of presenting alternative survival curves to respon- duction in annual mortality risk and the other half of
dents. Two common measures are expressing the bene- the sample to value the equivalent benefit expressed as
fit as a reduction in mortality risk or as a gain in life ex- a gain in life expectancy. There are 2 issues on which
pectancy. With the risk reduction method, the benefit is the study sheds light. First, we examine whether will-
usually expressed as an absolute reduction in probabil- ingness to pay (WTP) for a longevity gain is sensitive to
ity of death (or the complementary increase in survival the framing of the benefit. That is, we ask whether dif-
probability) over a specified time period. However, any ferent methods of expressing an equivalent benefit
reduction in mortality risk implies a gain in life expec- yield different estimates of WTP. Second, we compare
tancy, and it is relatively simple to convert a reduction the validity of WTP estimates generated by alternative
in mortality risk to the equivalent life expectancy gain. methods by using consistency of the estimates with
Both methods are potentially useful summaries be- theoretical predictions as a (construct) validity check.
cause each collapses a shift in the survival curve into a For example, one would expect that WTP for longevity
single number. However, both methods have limita- benefits would be larger for people with higher in-
tions—expressing risk reduction as a probability may comes and for benefits of greater magnitude (or scope).
be cognitively difficult, and expressing risk reduction One might also expect WTP for longevity benefits to in-
as a change in life expectancy does not describe a crease with the quality of life expected during the
unique change in the survival curve. added longevity. In this study, we use sensitivity of
Over the past 20 years, economists have gained con- WTP to scope as a primary test of validity. Sensitivity of
siderable experience with the risk reduction method by WTP to income, predicted quality of life, and other
asking survey respondents to value small changes in sociodemographic variables are used as secondary
their risk of death in a specified time period (often 1 tests of validity.
year). A significant body of research suggests that peo- The remainder of the article is structured as follows.
ple have difficulty thinking about and distinguishing In section 2, we present background information on the
among small quantitative probabilities,2-6 and this diffi- use of sensitivity to scope as a tool for evaluating the va-
culty is evident in CV surveys of mortality risk reduc- lidity of CV instruments. Section 3 describes survey de-
tions. Although most CV studies do not directly test re- sign and methods for using survey data to test the re-
spondents’ comprehension of basic probability search hypotheses. In section 4, we present survey
concepts, 2 studies that did found that only about 50% results and an evaluation of the communication meth-
to 60% of respondents could correctly identify the ods based on sensitivity to scope and the secondary va-
larger of 2 risk reductions expressed as probabilities.7,8 lidity criteria. We conclude with a discussion of the re-
The cognitive difficulties associated with small sults and proposals for future research in section 5.
probabilities have led to recent attempts to use life ex-
pectancy gain as an alternative for eliciting the value of 2. Background
longevity benefits. Johannesson and Johansson9,10 ex-
amined willingness to pay now for an additional year A life expectancy framing may seem preferable to a
of life expectancy conditional on reaching age 75, and risk reduction framing because it avoids difficulties
Johnson and others11 estimated willingness to pay for with explaining small probabilities, yet it is not obvi-
an “added year of life” with certainty. To our knowl- ous that a life expectancy framing is superior for com-
edge, these studies are the first to ask respondents to municating longevity benefits. There is no empirical
value benefits described in terms of life extension, with evidence comparing the methods in this context and
the Johannesson and Johansson studies being the only very little evidence about the public’s understanding of
ones to explicitly use a life expectancy framing. Al- the life expectancy concept in general. Given that we
though these studies are promising in that respondents face a choice of methods for communicating a life ex-
appear willing to answer questions about the value of tension benefit, how should we choose between them?
longevity benefits, they did not examine whether val- One way to gain insight into this question is to elicit
ues were sensitive to the choice of framing or whether a values for the same good using both methods. Similar
life expectancy framing is a valid alternative to tradi- results would obviate the need for a choice and provide
tional risk reduction descriptions. evidence of convergent validity of the valuation meth-
This article addresses the question of how to best to ods. If the methods yield dissimilar results, criteria are
communicate a life extension benefit in the context of required for selecting the more appropriate method.

HEALTH ECONOMICS 469


MORRIS, HAMMITT

One criterion is to compare CV estimates with theo- rial was used for this study. Multiple follow-up at-
retical predictions about how the estimates should tempts were made to reach each respondent.
vary according to factors logically related to WTP. One The CV question was based on WTP for a hypotheti-
theoretical prediction is that WTP should be sensitive cal pneumonia vaccine. Half of the survey respondents
to scope; that is, it should depend on the size of the ben- received a version in which the vaccine benefit was ex-
efit. Many CV studies have been criticized for insensi- pressed as a life expectancy gain (hereafter referred to
tivity to scope, meaning that respondents’ WTP for as the life expectancy subsample) and half received a
mortality risk reductions did not increase with the size version in which the equivalent benefit was expressed
of the risk reduction. In most cases where WTP did in- as a reduction in average annual chance of death (here-
crease with the size of the risk reduction, it did not in- after referred to as the risk reduction subsample). Exact
crease as much as economic theory predicts it should.† wording of the CV question for each subsample is given
Under reasonable assumptions,‡ economic theory in Appendix B.
predicts that WTP for a larger quantity of a good ex- To test for sensitivity to scope, each subsample was
ceeds WTP for a smaller quantity. For the special case further split and asked to value goods of different mag-
in which the good in question is a short-term reduction nitude, resulting in a total of 4 subsamples. Two of the 4
in the probability of death, WTP should be nearly pro- subsamples received a version in which they were
portional to the change in probability. That is, if a re- asked WTP now for a vaccine given at age 60, and the
duction in annual mortality risk from 3 in 100,000 to 2 other 2 subsamples received a version in which they
in 100,000 is valued at $50, then a larger reduction from were asked WTP now for a vaccine given at age 70. Be-
3 in 100,000 to 1 in 100,000 should be valued at about cause receiving the vaccine at age 60 includes the bene-
$100. WTP may deviate from proportionality if the pay- fit of receiving the vaccine at age 70 as well as addi-
ment constitutes a sizable portion of the respondent’s tional benefit between ages 60 and 70, it is
income or yields a large change in mortality risk,12-14 unambiguously preferred, regardless of time prefer-
but these effects are negligible in the context of WTP for ence. Respondents whose age exceeded the age of vac-
small reductions in mortality risk.15,16 cination in the survey version to which they were ran-
In the manner just described, economic theory pro- domized were not asked a WTP question.
vides a criterion for defining adequate sensitivity of The magnitude of the benefit depends on whether
WTP to scope for short-term mortality risk reductions. the respondent received the version with vaccination
However, the good that we are interested in valuing—a at age 60 or with vaccination at age 70, and the framing
continuing risk reduction—is more complex. The in- of the benefit depends on whether the respondent re-
tervention provides a series of annual risk reductions. ceived the version with benefit expressed as life expec-
WTP for a series of risk reductions can be evaluated us- tancy change or as a reduction in the annual probability
ing a simple economic model, as described in Appen- of dying. Based on pretesting of the survey instrument,
dix A. we elected to use a hypothetical pneumonia vaccine
with a benefit about twice as large as the actual benefit
3. Methods estimated from known pneumonia mortality rates and
vaccine effectiveness.
3.1. SURVEY DESIGN For respondents randomized to the risk reduction
subsample, baseline risk was expressed as an average
We employed a professional survey firm to adminis- annual chance of dying and the vaccine benefit was ex-
ter a 2-part CV survey from December 1998 to March pressed as an absolute reduction of 0.2% in the annual
1999. The 1st component of the survey was a national average chance of dying. Respondents valuing the vac-
random-digit-dial phone interview used to recruit sub- cine at age 60 were told it would reduce their average
jects and gather socioeconomic data. The 2nd compo- annual mortality risk from 4.8% to 4.6% for the rest of
nent of the survey consisted of a follow-up phone inter- their life; those valuing the vaccine at age 70 were told
view administered after respondents received a mailed it would reduce their average annual mortality risk
packet of material, although none of the mailed mate- from 7.0% to 6.8%. In both cases, the complementary
annual survival probabilities were also stated. Respon-
dents randomized to the life expectancy subsample

The issue of inadequate sensitivity to scope is reviewed in detail were told that the benefit of receiving the vaccine at age
in Hammitt and Graham.8 60 (70) was an increase in life expectancy from 21 years

These assumptions include nonsatiation and that more of a good to 21 years, 11 months (from 14 years to 14 years, 5
is preferred to less.
months).

470 · MEDICAL DECISION MAKING/NOV–DEC 2001


USING LIFE EXPECTANCY TO COMMUNICATE BENEFITS

The survey question consisted of 2 parts. After pre- 3.3. STATISTICAL METHODS
senting information about baseline risk, the respondent
was asked whether he or she would consider getting We estimated parametric regression models using
the vaccine (either at age 60 or at age 70, depending on WTP as the dependent variable. Because we did not
the subsample). If the respondent answered “yes,” he elicit point estimates of WTP, each respondent’s WTP is
or she was presented with a WTP question. If “no,” he unobserved but bounded by the bids presented in the
or she was presented with a follow-up question with re- double-bounded dichotomous-choice question. This
gard to the reason for not considering the vaccine. format results in either interval-censored data, in
Respondents who indicated that they would con- which we know both the lower and upper bounds of
sider getting the vaccine were presented with a double- the dependent variable, or right-censored data, in
bounded dichotomous-choice WTP question. With which we know only the lower bound. We assume all
this format, each respondent is randomly assigned an WTP values are greater than or equal to zero. Using SAS
initial bid. If the respondent answers “no” to the initial PROC LIFEREG,17 we fit a variety of models using the
bid, a follow-up question with a predetermined lower method of maximum likelihood. In preliminary model
bid is presented. If the respondent answers “yes” to the fitting, we examined both log normal and Weibull dis-
initial bid, a follow-up question with a predetermined tributions. Model results were similar for both distribu-
higher bid is presented. Three bid vectors of (initial/ tions, with median WTP estimates slightly lower using
higher/lower) 220/$700/$40, 400/$1500/$80, and 750/ the log normal distribution. A Weibull distribution was
$3500/$130 were selected to span the range of WTP es- assumed in all subsequent analyses.
timates observed in pretesting. The payment vehicle
was specified as an out-of-pocket expense to be paid 4. Results
now for the pneumonia vaccine to be received either at
age 60 or at age 70. Respondents were reminded to con- 4.1. SAMPLE CHARACTERISTICS
sider their current budget and expenses.
The survey also included questions in which the re- Of 1456 participants who were recruited, 1104 par-
spondents were asked to rate on a scale from 1 to 10 ticipated in the 2nd telephone interview (response rate
their perceived quality of life at their current age and of 75%). Of these, 134 respondents were excluded be-
their predicted quality of life at the age of 65. cause their age exceeded the age of vaccination in the
survey version to which they were randomized. Thus, a
3.2. RESEARCH HYPOTHESES total of 970 respondents completed the pneumonia
vaccine questionnaire.
We examine 3 primary hypotheses. First, we test for Of the 970 respondents who received the pneumo-
sensitivity of WTP to the framing of the vaccine benefit. nia vaccine question, 681 (70%) said they would con-
That is, we ask whether estimated WTP depends on sider getting the vaccine. The remaining 289 indicated
whether the benefit was described as an increase in life that they would not consider getting the vaccine or did
expectancy or a reduction in annual probability of dy- not know whether they would consider it. Only re-
ing. Our null hypothesis is that WTP is insensitive to spondents who indicated that they would consider the
the framing of the benefit. vaccine were presented with the WTP question. Re-
Second, we test for sensitivity of WTP estimates to spondents who indicated that they would not consider
scope within the life expectancy and risk reduction getting the vaccine were similar to those who indicated
subsamples. That is, we ask whether the ratio of WTP they would, except they were younger (mean age 39 vs.
for the vaccine at age 60 to WTP for the vaccine at age 70 41 years), more likely to have children younger than 18
depends on the framing of the benefit. For each (50% vs. 42%), and more likely to be white (83% vs.
subsample, the null hypothesis is that WTP estimates 79%). There were no significant differences in income,
are not sensitive to scope, that is, that there exists no years of education, percentage employed, percentage
difference in WTP for vaccine at age 60 versus vaccine male, percentage married, or predicted quality of life at
at age 70. age 65 (using a 2-sample t test with P = 0.05). Respon-
Third, we test for associations between WTP and dents who received the life expectancy version of the
factors that are logically related to WTP for longevity survey were more likely to indicate that they would not
benefits, such as income and predicted quality of life. consider getting the vaccine (33% vs. 26%, P = 0.01).
We predict that, controlling for other socio- About 70% of respondents who would not consider the
demographic characteristics, WTP should increase vaccine reported that vaccine benefits are “too small”
with these factors. or “uncertain.” Another 10% cited safety concerns, 3%

HEALTH ECONOMICS 471


MORRIS, HAMMITT

Table 1 Sample Characteristics Table 2 Crude Willingness to Pay Responses


for Pneumonia Vaccine: Joint Frequency
Life Risk
Expectancy Reduction
Frequency of Response:
Variable Subsample Subsample
Number (Proportion)
n 332 349
Life Risk
Percentage receiving version with
Bids 1st (2nd) Expectancy Reduction
vaccine at age 60 49 48 Responses 1st/2nd n Subsample Subsample
Percentage receiving version with
vaccine at age 70 51 52 $220($700/$40) 231a
Agea 40.8 40.4 No/no 22 11 (0.10) 11 (0.09)
Percentage male 45 42 No/yes 82 34 (0.30) 48 (0.40)
Incomeb $50,600 $45,500 Yes/no 87 41 (0.37) 46 (0.39)
Educationc 14.5 14.3 Yes/yes 40 26 (0.23) 14 (0.12)
Percentage employed full-time 63 60 $400($1500/$80) 225
Percentage married 58 52 No/no 46 20 (0.18) 26 (0.23)
Percentage with children < 18 43 41 No/yes 95 55 (0.49) 40 (0.36)
Percentage white 81 75 Yes/no 60 27 (0.24) 33 (0.29)
Mean predicted quality of life at Yes/yes 24 11 (0.10) 13 (0.12)
age 65 (1 to 10 scale) 7.4 7.4 $750($3500/$130) 225
a. Measures respondent’s median age within the following categories: (18- No/no 55 24 (0.22) 31 (0.26)
24), (25-29), (30-34), (35-39), (40-44), (45-49), (50-54), (55-59), (60-64), (65- No/yes 99 43 (0.40) 56 (0.47)
69), and (70+). Age 70 was used for the upper bound.
b. Measures respondent’s median household income within the following Yes/no 54 27 (0.25) 27 (0.23)
categories: (<$15K), ($15 to $25K), ($25K to $40K), ($40K to $50K), ($50K to Yes/yes 17 13 (0.12) 4 (0.03)
$75K), ($75K to $100K), and (>$100K). $15K and $100K were used for the
lower and upper bounds, respectively. a. For example, 231 respondents received an initial bid of $220, of which
c. Measures respondent’s years of education, where less than high school = 104 indicated that they would not be willing to pay $220 for the vaccine and
10; graduated high school = 12; some college = 14; graduated college = 16; 127 indicated that they would be willing to pay $220 for the vaccine. The
and graduate or professional school = 18. 104 respondents who declined were subsequently offered a lower bid of
$40. Of these, 22 indicated that they would not be willing to pay $40
whereas 82 respondents indicated that they would be willing to pay $40 for
the vaccine. The 127 respondents who initially expressed willingness to
pay $220 were then presented with a larger bid of $700. Of these, 87 indi-
voiced a general dislike for vaccines, and 17% pro- cated that they would not be willing to pay $700 and 40 respondents indi-
vided no reason. cated that they would be willing to pay $700 for the vaccine.

Table 1 presents sample characteristics for the life


expectancy and risk reduction subsamples. The full
sample had a mean age of about 41 and was predomi-
nantly white (78%), female (56%), married (55%), and tion of bid amount (shown on the horizontal axis). The
employed full-time (62%). The mean annual house- upper (lower) curve represents the probability of ac-
hold income ($48,000) and years of education (14.4) cepting the bid based on the upper bound (lower
were above the national averages of $44,000 and 12.7 bound) of each respondent’s WTP interval. As ex-
years, respectively.18 The subsamples were similar, pected, the fraction accepting is inversely related to the
with no significant differences between sample means bid amount. The smooth curve between the step func-
except for percentage white, which was greater in the tions represents the Weibull model fit to the unob-
life expectancy subsample (P = 0.05). served WTP estimates. The Weibull model lies almost
entirely between the upper and lower bounds, suggest-
ing an adequate fit to the data.
4.2. WTP FOR PNEUMONIA VACCINE Table 3 presents estimated median WTP for the
pneumonia vaccine for each subsample defined by the
Table 2 summarizes the crude responses for the life framing and magnitude of the benefit. Medians were
expectancy and risk reduction subsamples. Pooled estimated independently for each subsample using a
crude responses are presented graphically in Figure 1. regression model with no covariates and assuming a
The step functions shown in Figure 1 are Weibull distribution. Across the 4 subsamples, median
nonparametric Kaplan-Meier estimators that represent WTP for a pneumonia vaccine ranged from $280 to
the probability of saying “yes” to a WTP bid as a func- $451.

472 · MEDICAL DECISION MAKING/NOV–DEC 2001


USING LIFE EXPECTANCY TO COMMUNICATE BENEFITS

Table 3 Median Willingness to Pay (WTP) for


1
Pneumonia Vaccine by Subsample
0.9

0.8 WTP60 WTP70 WTP60/WTP70


0.7
Life expectancy (LE) $451 $291 1.55*
P(ACCEPT BID)

0.6
UPPER-BOUND WTP Risk reduction (RR) $296 $280 1.06
0.5 LOWER-BOUND WTP
Ratio WTPLE/WTPRR 1.52** 1.04
0.4 Weibull
*P < 0.05. **P < 0.01.
0.3

0.2

0.1
would be no greater than WTP for the good of lesser
0
0 500 1000 1500 2000 2500 3000 3500
magnitude, vaccination at age 70.
WTP BID For the life expectancy subsample, WTP60/WTP70 =
1.55, indicating that median WTP for vaccination at age
60 was 55% greater than median WTP for vaccination
Figure 1. Kaplan-Meier (nonparametric) estimates of willingness to
pay (WTP) compared with fitted Weibull model. at age 70 (P < 0.05) among those who received the bene-
fit expressed as a change in life expectancy. For the risk
reduction subsample, WTP60/WTP70 = 1.06, indicating
that median WTP for vaccination age 60 is 6% greater
4.3. SENSITIVITY OF WTP TO BENEFIT FRAMING than median WTP for vaccination at age 70 among
those who received benefit expressed as a reduction in
The last row of Table 3 presents the ratio of median probability of dying, although this difference was not
WTP in the life expectancy subsample to median WTP statistically significant. Thus, the hypothesis that WTP
in the risk reduction subsample (denoted WTPLE/ is insensitive to scope can be rejected for the life expec-
WTPRR) for vaccination either at age 60 or at age 70. If tancy subsample (P < 0.05) but not for the risk reduc-
WTP estimates were insensitive to the framing of the tion subsample (P = 0.72).
benefit, the value of these ratios would be 1. For vacci- For the life expectancy subsample, the WTP esti-
nation at age 60, WTPLE/WTPRR = 1.52, indicating that mates are consistent with the prediction that WTP for a
those who received the benefit expressed as a change in larger good should exceed WTP for a smaller good. As
life expectancy had a median WTP 52% greater than noted earlier, economic theory also provides insight
those who received the same benefit expressed as an into how much larger WTP for the larger good is ex-
absolute risk reduction (P < 0.01). For vaccine at age 70, pected to be. Using a simple model in which WTP is
WTPLE/WTPRR = 1.04, indicating that those who re- proportional to discounted quality-adjusted life expec-
ceived the benefit expressed as a change in life expec- tancy (Appendix A), we derive the predicted ratio of
tancy had a median WTP 4% greater than those who re- WTP for the vaccine at age 60 to WTP for the vaccine at
ceived the equivalent benefit stated in terms of absolute age 70. The ratio is independent of the respondent’s
risk reduction, although this difference was not statisti- age.
cally significant. Thus, the hypothesis that WTP is in- For simplicity, we weight all years equally, so WTP
sensitive to the framing of the benefit can be rejected for is proportional to the gain in discounted life expec-
the subsample with vaccination at age 60 (P < 0.01) but tancy. As shown in Figure 2, the predicted WTP ratio is
not for the subsample with vaccination at age 70 (P = a function of the discount rate, r.§ For a discount rate of
0.88). 0, WTP60/WTP70 is simply the ratio of life expectancy
gains calculated from age 60 (or before), about 2.6.¶ Be-
cause the vaccine at age 60 provides greater near-term
4.4. SENSITIVITY OF WTP TO SCOPE

The last column of Table 3 presents the ratio of me- §


We assume the utility discount rate and consumption discount
dian WTP for vaccination at age 60 to median WTP for rate are equal, as is conventional in cost-effectiveness analysis. If the
vaccination at age 70 (denoted WTP60/WTP70) for the consumption discount rate exceeds the utility discount rate, the cal-
life expectancy and risk reduction subsamples. If WTP culated ratio will be larger.

The value can be calculated as the ratio of the life expectancy
estimates were insensitive to the scope of the good, the gain from age 60 to the life expectancy gain from age 70, equal to 11
value of these ratios would be 1. That is, WTP for the months divided by (5 months × 0.85), where 0.85 is the probability of
good of greater magnitude, vaccination at age 60, surviving from age 60 to age 70.

HEALTH ECONOMICS 473


MORRIS, HAMMITT

4 Table 4 Regression of Willingness to Pay


(WTP) for Pneumonia Vaccine on
Magnitude of Benefit, Framing
of Benefit, and Selected Sample Covariates
3
Life Risk
Full Expectancy Reduction
Variable Sample Subsample Subsample

2 n 618 301 317


Intercept 5.67 5.86 5.36
(0.550) (0.779) (0.725)
VACC60 0.914* 1.34* 1.09
1 (0.450) (0.633) (0.584)
LIFE_EXP 0.039a N/A N/A
–0.1 –0.05 0 0.05 0.1
(0.121)
Discount rate LIFE_EXP*VACC60 0.447a N/A N/A
(0.236)
Figure 2. Predicted ratio of willingness to pay for vaccine at age 60 SRQoL (1-10) 0.077* 0.0481 0.091
to willingness to pay for vaccine at age 70. (0.034) (0.0479) (0.048)
Age 0.00853 0.00256 0.018
(0.0074) (0.0110) (0.010)
benefits, the ratio increases with the discount rate. For AGE*VACC60 –0.0245* –0.0239 –0.029*
a 3% rate, the ratio is about 2.9. For discount rates less (0.011) (0.0154) (0.014)
than 0, the ratio falls to a minimum of about 2.1. Includ- Income ($1000) 0.00677** 0.00836* 0.00552
ing health-related quality-of-life weights that decline (0.0025) (0.00359) (0.00349)
with age has an effect similar to increasing the discount Education (years) –0.0360 –0.032 –0.0295
rate, and yields a larger ratio. (0.0290) (0.0414) (0.0391)
As shown in Table 3, we estimated WTP60/WTP70 ra- WHITE –0.406** –0.474* –0.436*
tios of 1.55 and 1.04 for the life expectancy and risk re- (0.149) (0.230) (0.193)
duction subsamples, respectively. These values are Gender (1 = male) 0.101 0.527** –0.321
smaller than the minimum value implied by our sim- (0.125) (0.176) (0.169)
ple model, which suggests that the WTP estimates are Log likelihood –781.86 –383.07 –391.18
inadequately sensitive to scope. Note: SRQoL = predicted quality of life at age 65 on a scale from 1 ( worst
quality imaginable) to 10 (best quality imaginable). Standard error is in
Table 4 presents statistical results for the estimated parentheses.
regression equations for the full sample (i.e., pooling a. LIFE_EXP and LIFE_EXP*VACC60 joint P < 0.05.
responses across vaccination ages) and for the life ex- *P ≤ 0.05. **P ≤ 0.01.

pectancy and risk reduction subsamples. The full-


sample model includes an indicator variable
(LIFE_EXP) for framing of the longevity benefit, which subsample shows significant sensitivity to scope. This
is equal to 1 for the respondents to whom the benefit result is consistent with Table 3. Note, however, the
was described as a life expectancy gain and 0 for the re- negative interaction between age and VACC60 for each
spondents to whom the benefit was described as a re- subsample (P < 0.05 for the full sample and the risk re-
duction in annual mortality risk. duction subsample). This interaction implies declining
The full-sample and subsample models include an sensitivity to scope with increasing age.†† The effect is
indicator variable for magnitude of benefit. VACC60 is illustrated in Table 5, which shows WTP (as predicted
an indicator variable equal to 1 for the subsample pre- by the regression models in Table 4) for a 55-year-old
sented with vaccination at age 60 (the larger good) and white man and a 25-year-old white man (holding other
equal to 0 for the other subsample. AGE*VACC60 rep- covariates constant at the sample mean). Sensitivity to
resents the interaction between age and magnitude of scope can be assessed by examining the ratio WTP60/
benefit.
The coefficient on VACC60 is positive in both ††
subsamples but significant only in the life expectancy This pattern was also evident when we examined median WTP
in subsamples younger and older than 50 years.
subsample, indicating that only the life expectancy

474 · MEDICAL DECISION MAKING/NOV–DEC 2001


USING LIFE EXPECTANCY TO COMMUNICATE BENEFITS

Table 5 Predicted Median Willingness to Pay surviving long enough to benefit from the vaccine had
(WTP) for Selected Ages no significant predictive effect (results not shown).‡‡
Years of education is negatively but not significantly
Ratio WTP60/ associated with WTP in each subsample. We found no
Subsample Age WTP60 WTP70 WTP70 interaction between education and magnitude of the
benefit, suggesting that greater educational attainment
Life expectancy 55 $361 $352 1.03
is not associated with improved sensitivity to scope. To
Life expectancy 25 $685 $326 2.10
the extent that sensitivity to scope is a proxy for com-
Risk reduction 55 $164 $278 0.59
prehension of the magnitude of the goods being valued,
Risk reduction 25 $234 $163 1.44
this result suggests that greater educational attainment
Note: For white male with other covariates equal to full sample mean.
is not related to better comprehension of either a life ex-
pectancy or a risk reduction framing.

WTP70 in the last column. If WTP were proportional to 5. Discussion


discounted life expectancy, the value of this ratio
would be approximately 2.9 (assuming a 3% discount Obtaining credible estimates of the value of longev-
rate). For both ages, sensitivity to scope is greater for the ity benefits is important if we wish to efficiently allo-
life expectancy subsample than for the risk reduction cate resources among competing programs that extend
subsample, but in each subsample the ratio WTP60/ human lives. By comparing 2 major approaches to ex-
WTP70 for the 25-year-old is closer to the predicted op- pressing longevity benefits, we offer the present study
timal value than the corresponding ratio for the 55- as a contribution to the ongoing search for methods that
year-old. This finding runs counter to our a priori ex- enhance the validity of CV in the context of valuing
pectation that, all else equal, older respondents would longevity benefits.
be likely to exhibit greater sensitivity to scope because Results from this study suggest that WTP for a lon-
the benefits are closer in time and likely to be more sa- gevity benefit is sensitive to the framing of the benefit.
lient to them. Respondents valued benefits expressed as a life expec-
tancy gain more highly than identical benefits ex-
4.5. VARIATION IN WTP WITH pressed as a reduction in annual mortality risk. That al-
SOCIODEMOGRAPHIC CHARACTERISTICS ternative methods for expressing an identical benefit
yield dissimilar WTP estimates leads logically to the
Consistent with the hypothesis that a longevity ben- question of which method yields the “better”
efit is a normal good, income is positively associated estimates.
with WTP in all subsamples, although it is statistically To compare the validity of the alternative methods,
significant (P < 0.05) in only the full sample and the life we evaluated the respective WTP estimates for consis-
expectancy subsample (Table 4). The estimated income tency with theoretical predictions. We invoke sensitiv-
coefficient (0.0068 in the full sample) implies that for ity of WTP to scope as the primary criterion for assess-
an additional $1000 of household income, WTP for a ing the construct validity of the alternative methods.
pneumonia vaccine is $2.30 greater on average (at the We observed increasing WTP with increasing magni-
mean sample income). Although this effect appears tude of longevity benefit in the life expectancy
small, the implied income elasticity of WTP is about subsample but not in the risk reduction subsample.
0.30 (at the sample mean income), a value consistent Thus, our primary test of validity suggests that the life
with reported empirical income elasticities for WTP for expectancy method demonstrates greater validity than
mortality risk reduction. the risk reduction method.
Predicted quality of life at age 65 (SRQoL), as mea- We examined the relationship between WTP and
sured on a scale of 1 (worst quality imaginable) to 10 other factors such as income and predicted quality of
(best quality imaginable), is positively associated with life as secondary tests of validity. The methods per-
WTP for pneumonia vaccine for all subsamples, al- formed comparably with regard to these factors. Both
though the effect is statistically significant only for the methods yield the expected positive relationship be-
full sample. The estimated full-sample regression coef-
ficient implies that WTP for the pneumonia vaccine is ‡‡
about $23 greater if predicted quality of life is 1 unit The question asked: “How would you rate your chance of living
to age 60 (70) compared with others of your age and gender? Is your
larger (at the sample mean SRQoL of 7.4). A related chance much higher, a little higher, about the same, a little lower, or
question about the respondent’s perceived chance of much lower?”

HEALTH ECONOMICS 475


MORRIS, HAMMITT

tween income and WTP, with implied income elastici- cate that they would not consider getting the pneumo-
ties within the range observed in the literature. Both nia vaccine. To the extent that this negative response
methods exhibit a positive association of similar mag- reflects a general rejection of the CV questionnaire
nitude between predicted quality of life at age 65 and rather than a genuine response to the question, it can be
WTP, although the effect is statistically significant only argued that greater scenario rejection occurred using
for the full sample. Likewise, the methods produce the life expectancy framing.
similar relationships between WTP and age and be- Despite these limitations, we believe that expressing
tween WTP and education. Thus, the secondary tests of longevity benefits in terms of life expectancy holds
validity suggest that the methods are of comparable promise for enhancing the validity of health care CV
validity. applications. Future research should focus on improv-
We conclude that the life expectancy method ap- ing our understanding of how the public comprehends
pears to perform better than the risk reduction method the life expectancy concept, which should enable us to
in at least one important regard—sensitivity scope— improve risk communication tools by identifying and
and no worse than the risk reduction method in other “designing out” common misperceptions, as well as of-
regards. To the extent that enhanced sensitivity to fering insight into methods for obtaining appropriate
scope reflects better comprehension of the valuation scope sensitivity. In addition, it would be helpful to
task, we have partial evidence that a life expectancy compare the sensitivity of WTP to differences in lon-
framing is more readily understandable. If, indeed, the gevity benefit described as a gain in life expectancy or
life expectancy framing is more comprehensible, then as a reduction in annual mortality risk holding the time
the monetary value of longevity benefits is more likely period over which the risk is reduced constant and
to reflect true preferences if elicited using a life expec- varying the magnitude of the reduction in probability
tancy framing. of death. Future research should also compare the life
This promising finding is tempered by several limi- expectancy method with other risk communication
tations. First, a life expectancy framing appears to work methods not examined here, such as using relative ver-
less well for older respondents in that scope sensitivity sus absolute risk reduction,19 using cumulative rather
exhibited by the life expectancy subsample is stronger than annual mortality risk reduction,20 or using an al-
for younger respondents than for older respondents. ternative metric such as “number needed to treat” (the
Although the life expectancy format appears to work reciprocal of absolute risk reduction).21,22
better than the risk reduction format in all cases, its su- The growing popularity of health care CV studies
periority is less marked among older respondents. leads to the broader consideration of the need for crite-
Thus, our a priori expectation—that greater sensitivity ria by which to judge discrepant WTP estimates. We
to scope would be seen among older respondents be- suggest using sensitivity to scope as the primary crite-
cause they may find the good more salient and thus rion and sensitivity to factors such as income and qual-
consider the valuation question more carefully—is not ity of life as secondary criteria for comparing the valid-
borne out by the empirical results. ity of alternative CV methods. As the number of health
Second, the sensitivity to scope exhibited by the life care CV applications grows and the methods evolve, it
expectancy subsample falls short of the degree of sensi- will be important to examine the merits of various
tivity suggested by a simple economic model. The types of CV validity tests. Advances in both validity
model suggests that the ratio of WTP for the vaccine at testing and risk communication should be integrated
age 60 to WTP for the vaccine at age 70 should be larger into the conceptual framework for health care CV
than 2, but our empirical estimate is only 1.55. studies.23
Third, respondents who received the life expec- The authors thank Phaedra Corso for assistance with survey de-
tancy version of the sample were more likely to indi- sign and administration and Alan Krupnick for helpful comments.

476 · MEDICAL DECISION MAKING/NOV–DEC 2001


USING LIFE EXPECTANCY TO COMMUNICATE BENEFITS

APPENDIX A
Simple Economic Model of Willingness to Pay
for Continuing Reductions in Mortality Risk

To examine the theoretically predicted sensitivity of will- Using equation (2), the ratio of WTP at age a for the vaccine
ingness to pay (WTP) to the magnitude of the benefit from the taken at age 60 to WTP at age a for the vaccine taken at age 70
pneumonia vaccine, consider a simple model in which WTP is
for an increase in longevity is proportional to the gain in dis-
counted quality-adjusted life expectancy: ∞ q 60 − p (3)
a
1+ d
10 ∑t = 0 (t1 + r )tt ut
= 
v −a ∞ WTP60 m60
pv  qtv / pv − pt / pv  
WTPva = 
1  .
 mv ∑ ut , (1) a  1+ r  q 70 − p
pa  t =v
WTP70 m70 ∞
1+ d (1 + r )t −v  ∑t = 0 (t1 + r )tt ut
where WTPva is the individual’s WTP at age a for the vaccine
taken at age v. The probability of surviving from birth to age t Note that the WTP ratio is independent of the respondent’s
is pt in the absence of a vaccine andqtv if the vaccine is taken at age. For simplicity, we assume that the health-related quality
age v. Note that qtv = pt for all t < v and that the probability of of life is 1 for all ages (equivalently, that WTP is proportional
surviving from age a to age v equals pv /pa. to discounted life expectancy). Using values of ut that decline
The bracketed term in equation (1) is the individual’s WTP with age would yield a larger WTP ratio. We also assume the
at age v. It is the discounted quality-adjusted life expectancy marginal utility of income is equal at ages 60 and 70, so m60/
(ut is the health-related quality-of-life weight for age t and r is m70 = 1. Because mt is the inverse of the marginal utility of in-
the utility discount rate) multiplied by the inverse of the mar- come, diminishing marginal utility of income would imply
ginal utility of income at age v, mv . We allow for the possibil- that m60/m70 > 1 if income declines from age 60 to 70 and m60/
ity that the consumption discount rate d differs from the util- m70 < 1 if income increases. Consistent with standard practice
ity discount rate r. To calculate WTP at age a, we discount for in cost-effectiveness analysis, we assume the individual dis-
the time until the benefit is received (v – a) using the con- counts income and utility at the same rate, so that d = r. The
sumption discount rate d (because the benefit at age v is val- plausible alternative assumption is that d > r, which yields a
ued in monetary terms) and multiply by the probability of larger WTP ratio.
surviving from age a to age v. We set the baseline survival probabilities pt using the 1995
24
Making use of the fact that qtv = pt for t < v and canceling U.S. life table. The survival probabilities with the vaccine
the pv terms yields are modeled under the assumption that the vaccine reduces
the age-specific mortality rate by a constant factor, which is
v −a ∞
1+ r  qtv − pt
WTPva = 
mv chosen to yield the specified life-expectancy gain. The vac-
1+ d

pa
∑ (1 + r )t
ut . (2)
cine taken at age 60 reduces annual mortality risk by about
t =o
10%, and the vaccine taken at age 70 reduces annual mortal-
ity risk by about 5%. The resulting WTP ratio is plotted as a
function of the discount rate in Figure 2.

APPENDIX B
Contingent Valuation Questions

LIFE EXPECTANCY METHOD Would you consider getting the vaccine at age 60 (70)? [If re-
(WITH BID VECTOR 1: $220/$700/$40) spondent answers “yes,” continue with part 2.]
Part 2
Part 1
Now assume that you have to pay some money this year to
On average, a person aged 60 (70) has a life expectancy of have the vaccine available to you when you reach age 60 (70).
21 (14) years. That is, the average 60-year-old (70-year-old) Assume that you would need to pay this cost out of your own
will live to age 81 (84). Suppose that a pneumonia vaccine pocket; it would not be covered by insurance. Also assume
will be available to you when you reach age 60 (70). The vac- that no better vaccine would become available before you
cine is perfectly safe and if you get vaccinated when you are reach age 60 (70). Considering your current income and ex-
60 (70), your life expectancy will increase from 21 years to 21 penses, would you pay $220 this year to have the vaccine
years and 11 months (from 14 years to 14 years and 5 months). available for you when you reach age 60 (70)? [If respondent

HEALTH ECONOMICS 477


MORRIS, HAMMITT

answers “yes,” present higher bid of $700; if respondent an- that a pneumonia vaccine will be available to you when you
swers “no,” present lower bid of $40.] reach age 60 (70). The vaccine is perfectly safe, and if you get
vaccinated when you are 60 (70), your annual probability of
RISK REDUCTION METHOD dying each year would decrease from 4.8% to 4.6% (from 7%
to 6.8%). That is, your annual probability of surviving each
(WITH BID VECTOR 1: $220/$700/$40)
year will increase from 95.2% to 95.4% (from 93% to 93.2%).
Would you consider getting the vaccine at age 60 (70)? [If re-
Part 1 spondent answers “yes,” continue with part 2.]
On average, a person aged 60 (70) has a 4.8% (7%) proba-
Part 2
bility of dying each year from all causes. That is, the average
chance of living at least 1 more year is 95.2% (93%). Suppose Same as above.

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