STATISTICS FOR HEALTH TECHNOLOGY

CASE STUDY SYNOPSIS

Group Number 3

Name Reg No.

Sneha Gupta 20bec047

Gudavalli Sudhakar 20bec016

RIPUDAMAN N SINGH 20bds043

NAMRATHA B T 20bds035

Under The Guidance of

Dr. Ramesh Athe

Assistant Professor, Data Science, and Intelligent Systems

Indian Institute of Information Technology, Dharwad

March- 2023
Title:

A Systematic Review and Meta-Analysis of Environmental Factors and Physical Attributes Associated with
Thyroid Cancer

Introduction:

Thyroid cancer is a common type of cancer that affects the thyroid gland. There is increasing evidence
suggesting that environmental factors and physical attributes may play a role in the development of thyroid
cancer. This systematic review and meta-analysis aimed to investigate the association between
environmental factors and physical attributes with thyroid cancer.

Objective:

The objective of this systematic review and meta-analysis is to investigate the association between
environmental factors and physical attributes and the risk of thyroid cancer. The review will aim to
synthesize the available evidence from published studies and provide a comprehensive overview of the
environmental and physical risk factors associated with thyroid cancer. The study will use a systematic
approach to identify and select relevant studies, assess the quality of the evidence, and conduct a
meta-analysis to quantify the overall effect size of the identified risk factors. The findings of this study may
inform public health policies and interventions aimed at reducing the burden of thyroid cancer by identifying
modifiable risk factors.

Methodology:

➔ Literature search

We conducted a comprehensive search of electronic databases, including PubMed, Google Scholar,

and Cochrane, using appropriate search terms related to environmental factors and physical
attributes with thyroid cancer. We included studies that examined the association between
environmental factors and physical characteristics with thyroid cancer incidence or mortality. We
excluded studies that did not meet our inclusion criteria or had a high bias risk.

➔ Inclusion and Exclusion Criteria

◆ Inclusion criteria:
● Studies that investigate the association between environmental factors or physical
attributes and thyroid cancer
● Studies that include Female (middle-aged) participants
● Studies that include Human participants
● Studies that are published in peer-reviewed journals or other credible sources
● Studies that are available in the English language
 ◆ Exclusion criteria:
● Studies that do not investigate the association between environmental factors or
physical attributes and thyroid cancer
● Studies that use an animal or in vitro model
● Studies that are not relevant to the research question
● Studies that are not available in full-text format
● Studies that are published in non-peer-reviewed sources, such as conference
proceedings, abstracts, or dissertations.

➔ Data Extraction

We extracted data from the included studies, including study design, study population, exposure to
environmental factors and physical attributes, and thyroid cancer outcomes.

Steps were taken for filtering:

● PubMed
a) Text Availability
i) Free full text
ii) Full text
b) For article type:
i) Meta-Analysis
ii) Systematic review
c) Species
i) Humans
d) Language
i) English
e) Sex
i) Female
f) Age
i) Adults:19-44 years
ii) Middle-aged +Aged: 45+ years
iii) Middle Aged:45-64 years

● Cochrane
○ Time
■ Since 2023

○ Language
■ English
○ For article type:
■ Review Articles
Results:

Our search yielded a total of 1192 potentially relevant studies.

● Pubmed-386
● Cochrane-806
After screening and applying our inclusion and exclusion criteria, we included 43 studies in our systematic
review and meta-analysis.
● Pubmed-39
● Cochrane-4

The included studies had a total of:

● Pubmed
○ Population:2679
○ Intervention:260551
○ Outcome:71302
● Cochrane
○ Population:9714
○ Intervention:911228
○ Outcome:220223

The studies investigated a range of environmental factors and physical attributes, including exposure to
radiation, smoking, alcohol consumption, obesity, and physical activity.

1. For Pubmed:
● 386-After PICO search
● 205-Using Filters (181 records removed)
● 180-Additional Filter(25 records removed)
● 36-After manually reading we finalize this many records for our case study. (144 records
removed).

2. For Cochrane:
● 806-AFter PICO search
● 150-Using Filters like time etc (656 records removed)
● 5-After manually reading the PICO and abstract of papers we finalize this many records for
our case study. (145 records removed).
PRISMA model:

We followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) model to
ensure transparent reporting of our systematic review and meta-analysis. We included a PRISMA flow
diagram to show the study selection process and a PRISMA checklist to ensure that we reported all
relevant information in our systematic review and meta-analysis.
Common variables

Title Author Populatio Age %f Technolog Ye thyroid Weight

n em y ar measure (or)
ale ments Height

Normal Adrenal and Thyroid Function Clarke et al. patients 55.9+- 32. ACE2 20 low unknown
in Patient who survive Covid-19 with 13 85 receptor 21 thyroid
Infection COVID-19 function

Thyroid hormone alterations in critically Vassiliadi et al. patients 59.3+- 31. Triturus 20 autoimmu unknown
and non-critically ill patients with with and 18.3 57 automated 21 ne
SARS-CoV-2 infection without analyzer hyperthyr
COVID-19 oidism

Thyroid Dysfunction in Relation to Lui et al. patient 53.5+- 48. - 20 excessive unknown
Immune Profile, Disease Status, and with 17.2 16 21 thyroid
Outcome in 191 Patient with COVID-19 function
COVID-19

Thyroid Dysfunction in Critically Ill Ballesteros Vizoso patients 59 ± 29. thyroid 20 unknown unknown
COVID-19 Patients. Relationship with et al. with 12 48 hormone 21
In-Hospital Mortality COVID-19 analysis.

Low FT3 is an independent marker of Dutta et al. patients 54 32. Retrospec 20 unknown unknown
disease severity in patients with 62 tive cohort 21
hospitalized for COVID-19 COVID-19 study

Risk of Thyroid Nodular Disease and Kosma Wolinski, Agata Czarnywojtek, thyroid 45.1 61. Meta-Anal 20 hazard unknown
Thyroid Cancer in Marek Ruchala cancer 29 ysis 14 radio
Patients with Acromegaly – patients %
Meta-Analysis and
Systematic Review

Iodine fortification of foods and Santos JAR, Christoforou A, Trieu K, included Infant, 15. Randomis 20 unknown unknown
condiments, other than salt, for McKenzie BL, Downs S, Billot L, Webster all Childr 01 ed 19
preventing iodine deficiency disorders J, Li M population en,Ad % controlled
s, ult trials
including (RCTs),Qu
pregnant asi-RCTs
women,
from any
country

Clinicopathological features of primary Toshitetsu Hayashi1*, Mitsuyoshi : Primary 39.3 61. Meta-Anal 20 unknown unknown
thyroid Burkitt’s lymphoma: a Hirokawa1,Seiji Kuma1,Miyoko Higuchi1, thyroid 53 ysis 20
systematic Ayana Suzuki1,Risa Kanematsu1,Takumi Burkitt’s %
review and meta-analysis Kudo2, Naomi Katsuki3,Reiji Haba4 and lymphoma
Akira Miyauchi5 patient

The Type 2 Deiodinase Thr92Ala Xichang Wang , Kan Chen , Chenyu Zhang Thr92Ala 18-65 43. 20 excessive unknown
Polymorphism Is , Haoyu Wang , Jiashu Li , Chuyuan Wang polymorph 60 systematic 21 thyroid
Associated with Higher Body Mass , Weiping Teng , Zhongyan Shan , and ism and % review function
Index and Fasting Glucose Yaxin Lai metabolic and
Levels: A Systematic Review and parameter meta-anal
Meta-Analysis s ysi

Thyroid Cancer and Nonsteroidal Dhaval Patel, Cari M. Kitahara, Yikyung Thyroid >40 48. Pooled 20 CHD unknown
Anti-Inflammatory Drug Use: Park, Linda M. Liao, Martha Linet, cancer 30 Analysis 15 mortality,
A Pooled Analysis of Patients Older Electron Kebebew, and Naris Nilubol patients % hazard
Than 40 Years of Age ratio

Thyroid Function Within the Reference layal Chaker, Christine Baumgartner, cardiovas 30 -80 43. thyroid 20 hazard height
Range and the Risk of Stroke: Wendy P. J. den Elzen, Tinh-Hai Collet, M. cular 8 hormone 16 radio and
Arfan Ikram, Manuel R. Blum, disorders, replaceme weight
Abbas Dehghan, Christiane Drechsler, in thyroid nt, lipid
Robert N. Luben function lowering,
patient and
antihy‐
pertensive
therapy
Clinical Parameters Are More Likely to Stephen P, Fitzgerald,1–3 Nigel G. Netherlan 45+ 89 Radioactiv 20 CHD height
Be Associated with Thyroid Hormone Bean,4,5 Henrik Falhammar,6–8 and Jono ds % e iodine 20
Levels than with Thyrotropin Levels Tuke4, communit therapy
y

Thyroid Antibody Status, Subclinical prospective 65+ 56 systematic 201 CHD unknown
Hypothyroidism, and the Risk of Coronary Tinh-Hai Collet, Douglas C. Bauer, Anne R. study % review and 4 mortality,
HeartDisease Cappola, Bjørn O. Åsvold, Stefan Weiler, Eric meta-analys hazard
Vittinghoff, Jacobijn i ratio
Gussekloo, Alexandra Bremner, Wendy P. J. den
Elzen, Rui M. B. Maciel, Mark P. J. Vanderpump,
Jacques Cornuz,
Marcus Dörr, Henri Wallaschofski, Anne B.
Newman, José A. Sgarbi, Salman Razvi, Henry
Völzke, John P. Walsh,
Drahomir Aujesky, and Nicolas Rodondi