8 Brain and Cognition 137 (2019)/Abstracts

Brain and Cognition 137 (2019) 103647 Multi-domain amnestic mild cognitive impairment (mdaMCI) is a
subtype of MCI in which two or more cognitive domains are
Neural substrate of recognition memory for unfamiliar faces impaired, as well as an intermediate state between normal cognitive
Shir Ben-Zvi et Feldman a, Nachum Soroker b, Daniel A. Levy c aging and Alzheimer’s disease. Event-related potentials (ERP) is an
a
Sackler Faculty of Medicine, Tel-Aviv University, Israel appropriate technique for identifying neurocognitive indexes of
b
Loewenstein Rehabilitation Hospital, Raanana, Israel MCI. The aim of this study was to compare the performance and
c
Baruch Ivcher School of Psychology, Interdisciplinary Center Herzliya, Israel ERP parameters, recorded during an old/new recognition task,
between 29 healthy adults and 26 mdaMCI adults, who did not differ
⇑ Corresponding author. in age and years of education.
The task consisted of three Study-Immediate Test (IT) blocks and
a 20-minutes Delayed Test (DT). In each Study, the same 30 words
(old words) were randomly presented, and participants have to
Face perception is a special visual skill due to its holistic charac-
memorize them. These old words were randomly presented once
ter, where the right hemisphere is thought to exercise a dominant
interspersed with 26/27 new words in each IT, and twice inter-
role (Ellis, 1983). Face perception also plays a critical role in social
spersed with 50 new words in DT.
interactions. Functional neuroimaging has identified a network of
The mdaMCI adults showed significantly lesser correct responses
regions contributing to face processing, including the fusiform face
and longer reaction times than controls. The N400 ERP component
area, occipital face area and the posterior part of the superior tempo-
amplitude was significantly larger: (1) in control than in mdaMCI
ral sulcus (Haist., Adamo, Wazny, Lee, & Stiles, 2013; Ishai, Schmidt,
adults at central locations, in IT; (2) in mdaMCI than in control
& Boesiger, 2005). However, it remains to be determined whether
adults, for old words at frontal locations, in DT; and (3) in DT than
there are regions that specifically support recognition memory for
in IT, for old words, in mdaMCI adults.
unfamiliar faces. In a neuropsychological study of first-event stroke
The results supported a decline in episodic memory in mdaMCI
patients, we aimed to identify neural substrates of face memory,
adults, as they showed worse performance, a reduction of processing
as assessed by the WMS-III face memory subtest. In order to identify
resources for evaluation and recognition of old/new words in IT,
brain lesions specifically implicated in face recognition deficits, we
along with an unsuccessful extra recruitment of processing
used (1) voxel-based lesion-symptom mapping (VLSM) and (2) cor-
resources to recognize old words in DT.
relation analyses between lesion extent in different regions of inter-
est and the magnitude of memory impairment. Behavioral analysis
doi:10.1016/j.bandc.2019.10.017
showed a pronounced decrease in performance in patients with right
hemisphere damage. VLSM revealed, in addition to the superior tem-
poral sulcus, significant impact of damage to frontal and parietal
regions outside the core face network on discrimination perfor- Brain and Cognition 137 (2019) 103649
mance. Greater parietal involvement was found on early stages of
retrieval. Frontal damage was implicated in overly-liberal criterion A gist orientation before retrieval impacts the objective content
setting but not in recognition of studied faces. A possible interpreta- but not the subjective experience of recollection
tion for a stronger parietal role in immediate face recognition may be Adrien Folville *, Arnaud D’Argembeau, Christine Bastin
greater reliance on recollection mechanisms specifically for immedi- University of Liège, Belgium
ate face recognition judgments. Further research will better charac-
terize the relationship between brain regions supporting face
⇑ Corresponding author.
recognition memory versus object recognition memory.

References Gist retrieval-orientation manipulations can experimentally

Ellis HD. The role of the right hemisphere in face perception. In: Young AW, editor.
Functions of the right cerebral hemisphere. London: Academic Press; 1983. p.
33–44.
Haist. F, Adamo M, Wazny JH, Lee K, Stiles J. The functional architecture for face-
processing expertise: fMRI evidence of the developmental trajectory of the core
and the extended face systems. Neuropsychologia 2013;51(13):2893–908.
Ishai A, Schmidt CF, Boesiger P. Face perception is mediated by a distributed cortical
network. Brain Research Bulletin 2005;67:87–93.
doi:10.1016/j.bandc.2019.10.016
Brain and Cognition 137 (2019) 103648
Neurocognitive indexes of multi-domain amnestic mild cognitive
impairment during an old/new words recognition task
Uxía Ferreiro-Caneiro *, Fernando Díaz, Montserrat Zurrón,
Santiago Galdo-Álvarez, Mónica Lindín
Grupo de Neurociencia Cognitiva Aplicada e Psicoxerontoloxía,
Departamento de Psicoloxía Clínica e Psicobioloxía, Facultade de
Psicoloxía, Universidade de Santiago de Compostela, Spain
⇑ Corresponding author.
decrease one’s ability to recollect objective details of past experience
(Rudoy, Weintraub, & Paller, 2009). Recent evidence further suggest
that the quantity of recollected details strongly predicts the associ-
ated subjective memory experience (i.e., vividness) (Folville,
D’Argembeau, & Bastin, 2019). Whether a gist retrieval-orientation
manipulation can hinder both the objective and subjective aspects
of episodic recollection remains unknown, however. To examine this
question, young participants were tested in two experimental ses-
sions. During each session, they took part to a cued-recollection task
in which they studied pictures associated with descriptive labels.
Before retrieval, participants were submitted either to a gist or a
control retrieval-orientation (one per session). At retrieval, they
were presented with the labels alone and they were asked to evalu-
ate the subjective vividness of their memories of the pictures and to
recall as many pictures details as they could. Results revealed that
the amount of recalled details was lower following the gist than
the control condition while the rates of vividness did not differ
between the two manipulations. Critically, the amount of recalled
details predicted the corresponding vividness ratings on a trial-by-
trial basis and the magnitude of this relationship was similar in
the gist and control conditions. These findings show that gist-retrie-
val-orientation manipulations can experimentally decrease the
amount of retrieved episodic details but that recollected memory
traces are still rich enough to be judged as subjectively vivid.