Table S3 Exploratory outcomes, per-protocol analyses.

p-value p-value Between group p-value

within within differences betwee
  MICT-group group HIIT/MICT-group group (95%CI) n group
Secondary outcome
Appetite feelings (Area under curve)
Hunger (cm*min)
Per-protocol analysis (n=24) (n=15)
Baseline 459 (359, 560) - 449 (325, 574) - 2.9 (-157, 162) 0.971
16-week 609 (430, 788) - 541 (321, 760) - 53.4 (-232, 338) 0.706
24-week 505 (399, 611) - 542 (410, 675) - -36.4 (-207, 135) 0.669
Change from baseline to 24-week 46.1 (-75.0, 172) 0.424 92.8 (-19.8, 205) 0.099 -46.8 (-125, 219) 0.584
Percent change 10.0 - 20.7 - - -

Desire to eat (cm*min)

Per-protocol analysis (n=24) (n=15)
Baseline 424 (315, 534) - 428 (288, 567) - -14.2 (-190, 161) 0.870
16-week 577 (446, 709) - 588 (408, 769) - -18.3 (-229, 192) 0.861
24-week 537 (397, 677) - 560 (383, 737) - -20.7 (-248, 207) 0.855
Change from baseline to 24-week 113 (-1.2, 231) 0.052 133 (13.6, 252) 0.031 -19.6 (-147, 186) 0.812
Percent change 26.7 - 31.0 - - -

Fullness (cm*min)
Per-protocol analysis (n=24) (n=15)
Baseline 1160 (1036, 1285) - 1128 (987, 1269) - 44.4 (-153, 241) 0.651
16-week 1143 (985, 1300) - 1053 (839, 1268) - 117 (-132, 365) 0.348
24-week 1300 (1195, 1404) - 1310 (1196, 1424) - -0.1 (-168, 169) 0.999
Change from baseline to 24-week 139 (25.2, 258) 0.019 183 (1.6, 364) 0.048 -43.2 (-155, 241) 0.660
Percent change 12.0 - 16.2 - - -

Prospective food consumption (cm*min)

Per-protocol analysis (n=24) (n=15)
Baseline 602 (492, 713) - 695 (537, 853) - -107 (-281, 66.8) 0.219
16-week 718 (570, 866) - 772 (562, 983) - -68.0 (-302, 166) 0.559
24-week 646 (487, 804) - 696 (496, 896) - -52.2 (-311, 206) 0.684
Change from baseline to 24-week 43.5 (-90.5, 187) 0.478 1.8 (-113, 116) 0.974 41.8 (-230, 147) 0.655
Percent change 7.2 - 0.3 - - -

Other exploratory outcomes related to

body mass
Energy expenditure
during exercise (Kcal*kg-1*h-1)            
Per-protocol analysis (n=24)   (n=16)      
Baseline 5.5 (5.0, 5.9) - 6.0 (5.5, 6.5) - -0.5 (-1.2, 0.1) 0.110
8-week 5.7 (5.3, 6.0) - 6.1 (5.5, 6.7) - -0.4 (-1.0, 0.2) 0.217
16-week 5.7 (5.2, 6.1) - 6.6 (5.9, 7.2) - -0.9 (-1.6, -0.2) 0.015
24-week 5.9 (5.5, 6.3) - 6.8 (6.1, 7.4) - -0.9 (-1.6, -0,2) 0.019
Change from baseline to 24-week 0.4 (0.2, 0.8) 0.005 0.8 (0.3, 1.2) 0.002 0.4 (-0.2, 0.9) 0.167
Percent change 7.3 - 13.3 - - -
Change from 8-16 weeks 0.0 (-0.2, 0.2) 1.000 0.5 (0.2, 0.8) 0.002 -0.5 (0.2, 0.8) 0.005
Percent change 0.0 - 8.2 - - -

Energy expenditure
during exercise (Kcal*kg-0.75*h-1)            
Per-protocol analysis (n=24)   (n=16)