Genetics From Genes To Genomes 5th Edition Hartwell Test Bank 1

Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes
Solution Manual for Genetics From Genes to Genomes

5th Edition by Hartwell Goldberg Fischer ISBN
0073525316 9780073525310
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Chapter 05
Linkage, Recombination, and the Mapping of Genes on Chromosomes
Multiple Choice Questions
In Drosophila, the genes y, f, and v are all X-linked. y f v females are crossed to wild-type males and the F1 females are test-
crossed. The F2 are distributed as follows:
yfv 3210
yf+ 72
y+v 1024
y++ 678
+fv 690
+f+ 1044
++v 60
+++ 3222
10,000
5-1
Copyright © 2015 McGraw-Hill Education. All rights reserved. No reproduction or distribution without the prior written consent of
McGraw-Hill Education.
1.
Which of the following linkage maps correctly shows the order and distance between the y, f, and v genes?
A.
f——35 mu——y——15 mu——v
B.
f——22 mu——y——15 mu——v
C.
y——35 mu——f——22 mu——v
D.
y——22 mu——v——15 mu——f
E.
y——15 mu——v——22 mu——f
Bloom's: 4. Analyze
Learning Objective: 05.03.02 Refine genetic maps based on data from three-point testcrosses.
Section: 05.03
Topic: Mapping: Locating Genes Along a Chromosome
5-2
2.
What is the coefficient of coincidence in this region?
A.
0
B.
0.2
C.
0.4
D.
0.6
E.
0.8
Bloom's: 3. Apply
Learning Objective: 05.03.03 Explain how a genetic map (in map units) is related to actual physical distance (in base pairs of DNA).
Section: 05.03
Females heterozygous for the recessive second chromosome mutations pn, px, and sp are mated to a male homozygous for all
three mutations. The offspring are as follows:
px sp cn 1,461
px sp + 3,497
px + cn 1
px + + 11
+ sp cn 9
+ sp + 0
+ + cn 3,482
+++ 1,539
10,000
5-3
3.
What is the genotype of the females that gave rise to these progeny?
A.
px+ sp cn / px sp+ cn+
B.
px+ sp cn+ / px sp+ cn
C.
px+ sp+ cn+ / px sp cn
D.
px sp cn+ / px+ sp+ cn
E.
Insufficient data
Bloom's: 4. Analyze
Section: 05.03
5-4
4.
Which of the three genes is in the middle?
A.
px
B.
sp
C.
cn
D.
Insufficient data
Bloom's: 4. Analyze
Section: 05.03
5-5
5.
Which of the following linkage maps correctly shows the order and distance between the px, sp, and cn genes?
A.
sp——0.21 mu——px——30.01 mu——cn
B.
sp——30.01 mu——px——0.21 mu——cn
C.
sp——0.2 mu——px——30 mu——cn
D.
px——0.2 mu——sp——30.2 mu——cn
E.
px——30.2 mu——sp——0.2 mu——cn
Bloom's: 4. Analyze
Section: 05.03
5-6
6.
Calculate the coefficient of coincidence in this region.
A.
0
B.
0.16
C.
0.33
D.
0.5
E.
0.66
Bloom's: 3. Apply
Section: 05.03
In peas, tall (T) is dominant to short (t), red flowers (R) is dominant to white flowers (r), and wide leaves (W) is dominant to
narrow leaves (w). A tall, red, wide-leaved plant is crossed to a short, white, narrow-leaved plant and the progeny are as
follows:
tall, red, wide 381

tall, white, wide 122
short, red, wide 118
short, white, wide 379
1000
5-7
7.
What is the genotype of the tall, red, wide-leaved parent?
A.
Tt Rr Ww
B.
Tt Rr WW
C.
TT RR WW
D.
TT Rr Ww
E.
TT RR Ww
Bloom's: 4. Analyze
Learning Objective: 05.01.02 Differentiate between parental and recombinant gametes.
Section: 05.01
Topic: Gene Linkage and Recombination
5-8
8.
Which of the three genes, if any, is unlinked to the others?
A.
T/t
B.
R/r
C.
W/w
D.
All three genes are linked.
Bloom's: 4. Analyze
Section: 05.03
5-9
9.
If two or more of the genes are linked, what map distance separates them?
A.
4 mu
B.
12 mu
C.
24 mu
D.
50 mu
E.
None of the genes are linked to each other.
Bloom's: 4. Analyze
Learning Objective: 05.01.03 Conclude from ratios of progeny in a dihybrid cross whether two genes are linked.
Section: 05.01
A dihybrid test cross is made between the genes C and D with the following results:
CcDd  ccdd
CD 222
Cd 280
cD 280
cd 218
1000
5-10
10.
Calculate the 2 value used test the hypothesis that the C and D genes are unlinked.
A.
0
B.
0.0576
C.
10.8
D.
14.4
E.
Cannot be determined
Bloom's: 3. Apply
Learning Objective: 05.04.01 Explain the purpose of the chi-square test.
Section: 05.04
Topic: The Chi-Square Test and Linkage Analysis
5-11
11.
How many degrees of freedom are there?
A.
1
B.
2
C.
3
D.
4
Bloom's: 3. Apply
Section: 05.04
5-12
12.
Given this data, which of the following is the most accurate range within which the p value falls, and what can be concluded?
A.
0 < p < 0.01, genes C and D are most likely unlinked.
B.
0 < p < 0.01, genes C and D are most likely linked.
C.
0.01 < p < 0.05, genes C and D are most likely linked.
D.
0.01 < p < 0.05, genes C and D are most likely unlinked.
Bloom's: 4. Analyze
Learning Objective: 05.04.03 Evaluate the significance of experimental data based on the chi-square test.
Section: 05.04
5-13
13.
If only 100 progeny had been counted and the same proportion observed, how would the p value and the conclusion drawn
about linkage change?
A.
The p value would increase, and the likelihood of linkage increases.
B.
The p value would decrease, and the likelihood of linkage increases.
C.
Neither the p value nor the likelihood of linkage would change.
D.
The p value would decrease, and the likelihood of linkage decreases.
Bloom's: 4. Analyze
Section: 05.04
5-14
14.
Which statement(s) below apply to the concept of gene linkage?
A. The different alleles of two or more genes that are on a chromosome are inherited in an manner inconsistent with Mendel's
Second law
B. Recombination between homologous chromosomes during meiosis results in different combinations of alleles for
different genes
C. Recombination between sister chromatids during meiosis results in different combinations of alleles for different genes
A.
A only
B.
B only
C.
C only
D.
A and B
E.
A, B, and C
Bloom's: 1. Remember
Learning Objective: 05.01.01 Define linkage with respect to gene loci and chromosomes.
Section: 05.01
5-15
15.
The R/r and S/s genes are linked and 10 map units apart. In the cross Rs/rS  rs/rs what fraction of the progeny will be RS/rs?
A. 5%
B. 10%
C. 25%
D. 40%
E. 45%
Bloom's: 4. Analyze
Learning Objective: 05.02.03 Discuss the relationship between the recombination frequency and the map distance separating two loci on a
chromosome.
Section: 05.02
Topic: Recombination - A Result of Crossing-Over During Meiosis
16.
If the map distance between genes A and B is 10 map units and the map distance between genes B and C is 25 map units,
what is the map distance between genes A and C?
A. 15 map units
B. 35 map units
C. either 15 map units or 35 map units, depending on the order of the genes
D.
The map distance between A and C can not be predicted from these data.
Bloom's: 4. Analyze
Section: 05.03
5-16
17.
In Drosophila, singed bristles (sn) and cut wings (ct) are both caused by recessive, X-linked alleles. The wild type alleles (sn+
and ct+) are responsible for straight bristles and intact wings, respectively. A female homozygous for sn and ct+ is crossed to a
sn+ct male. The F1 flies are interbred. The F2 males are distributed as follows
sn ct 13
sn ct+ 36
sn+ ct 39
sn+ ct+ 12
What is the map distance between sn and ct?
A. 12 m.u.
B. 13 m.u.
C. 25 m.u.
D. 50 m.u.
E. 75 m.u.
Bloom's: 4. Analyze
Section: 05.01
5-17
18.
In Drosophila, singed bristles (sn) and cut wings (ct) are both caused by recessive, X-linked alleles. The wild type alleles (sn+
and ct+) are responsible for straight bristles and intact wings, respectively. A female homozygous for sn and ct+ is crossed to a
sn+ct male. The F1 flies are interbred. The F2 males are distributed as follows
sn ct 13
sn ct+ 36
sn+ ct 39
sn+ ct+ 12
Of these 4 phenotypic classes of offspring, which of the following arose from a parental gamete produced by the F1 females?
A.
sn+ ct+ and sn+ ct flies
B.
sn+ ct+ flies only
C.
sn ct and sn+ ct+ flies
D.
sn+ ct and sn ct+ flies
E.
sn ct and sn ct+ flies
Bloom's: 4. Analyze
Section: 05.01
5-18
19.
Suppose the L and M genes are on the same chromosome but separated by 100 map units. What fraction of the progeny from
the cross LM/lm  lm/lm would be Lm/lm?
A. 10%
B. 25%
C. 50%
D. 75%
E. 100%
Bloom's: 4. Analyze
Learning Objective: 05.02.04 Explain why the value of the recombination frequency between any two genes is limited to 50%.
Section: 05.02
5-19
20.
The pairwise map distances for four linked genes are as follows: A-B = 22 m.u., B-C = 7 m.u., C-D = 9 m.u., B-D = 2 m.u., A-
D = 20 m.u., A-C = 29 m.u. What is the order of these four genes?
A.
ABCD
B.
ADBC
C.
ABDC
D.
BADC
E.
CADB
Bloom's: 4. Analyze
Learning Objective: 05.03.01 Establish relative gene positions using two-point cross data.
Section: 05.03
21. The zipper-like connection between paired homologs in early prophase is known as a
A. spindle fiber.
B. synaptic junction.
C. synaptonemal complex.
D. chiasma.
E. none of the choices are correct.
Learning Objective: 05.02.02 Describe the role of chiasmata in chromosome segregation during meiosis.
Section: 05.02
5-20
22.
The measured distance between genes D and E in a two point test cross is 50 map units. What does this mean in physical
terms?
A.
D and E are on different pairs of chromosomes.
B.
D and E are linked and exactly 50 map units apart.
C.
D and E are linked and at least 50 map units apart.
D.
either D and E are on different pairs of chromosomes or D and E are linked and exactly 50 map units apart
E.
either D and E are on different pairs of chromosomes or D and E are linked and at least 50 map units apart
Bloom's: 3. Apply
chromosome.
Section: 05.02
5-21
23.
The R/r and S/s genes are linked and 10 map units apart. In the cross Rs / rS  rs / rs what percentage of the progeny will be
Rs / rs?
A. 5%
B. 10%
C. 25%
D. 40%
E. 45%
Bloom's: 4. Analyze
chromosome.
Section: 05.02
24. Recombination frequencies near 50% suggest that

A. two genes are on different chromosomes.
B. two genes lie very close together on the same chromosome.
C. two genes are on the same chromosome but lie very far apart.
D. two genes are on different chromosomes, or two genes are on the same chromosome but lie
very far apart.
E. none of the choices are correct.
Bloom's: 2. Understand
Learning Objective: 05.02.04 Explain why the value of the recombination frequency between any two genes is limited to 50%.
Section: 05.02
5-22
25.
A dihybrid test cross is made between genes H and I. Four categories of offspring are produced: HI, Hi, hI, and hi. You wish
to use the 2 test to test the hypothesis that the H and I genes are unlinked. How many degrees of freedom would there be in
this test?
A. 1
B. 2
C. 3
D. 4
E. 0
Bloom's: 3. Apply
Section: 05.04
26. Which of the following processes can generate recombinant gametes?

A. Segregation of alleles in a heterozygote.
B. Crossing over between two linked heterozygous loci.
C. Independent assortment of two unlinked heterozygous loci.
D. Crossing over between two linked heterozygous loci and independent assortment of two
unlinked heterozygous loci
E. Segregation of alleles in a heterozygote, crossing over between two linked heterozygous
loci and independent assortment of two unlinked heterozygous loci
Section: 05.01
5-23
27. Crossing over takes place in paired bivalents consisting of ______ chromatids, and
involves _______ of the chromatids.
A. 2, 2
B. 2, 4
C. 4, 2
D. 4, 4
E. 8, 4
Learning Objective: 05.02.01 Explain the physical process by which recombination takes place.
Section: 05.02
28.
In Drosophila, the genes y (yellow body) and car (carnation eyes) are located at opposite ends of the X chromosome. In
doubly heterozygous females (y+ car+ / y car), a single chiasma is observed somewhere along the X chromosome in 90% of
the examined oocytes. No X chromosomes with multiple chiasmata are observed. What percentage of the male progeny from
such a female would be recombinant for y and car?
A. 5%
B. 10%
C. 45%
D. 55%
E. 90%
Bloom's: 4. Analyze
Section: 05.03
5-24
29.
Genes Q and R are 20 map units apart. If a plant of genotype QR / qr is selfed, what percentage of the progeny will be qr in
phenotype?
A. 4%
B. 10%
C. 16%
D. 20%
E. 40%
Bloom's: 4. Analyze
Section: 05.03
30.
The Q gene locus is 10 map units from the R gene locus which is 40 map units from the S gene locus:
Q——10 mu——R——40 mu——S
Which interval would likely show the higher ratio of double to single chiasmata?
A.
Q-R
B.
R-S
C. The ratios would be the same in the two intervals.

D. Two chiasmata never occur in the same interval.
Bloom's: 4. Analyze
Section: 05.03
5-25
31.
The map of a chromosome interval is:
A——10 mu——B——40 mu——C
From the cross Abc / aBC  abc / abc, how many double crossovers would be expected out of 1000 progeny?
A. 5
B. 10
C. 20
D. 40
E. 80
Bloom's: 4. Analyze
Section: 05.03
5-26
32.
The cross Lpq / lPQ  lpq / lpq is carried out and the L gene is found to be in the middle. What would be the genotypes of the
double crossover gametes in this cross?
A.
LPQ and lpq
B.
LpQ and lPq
C.
lpQ and LPq
D.
Lpq and lPQ
E. cannot be determined
Bloom's: 4. Analyze
Section: 05.03
5-27
33.
Suppose a three-point testcross was conducted involving the genes X, Y, and Z. If the most abundant classes are XYz and xyZ
and the rarest classes are xYZ and Xyz, which gene is in the middle?
A.
X
B.
Y
C.
Z
D. cannot be determined
Bloom's: 4. Analyze
Section: 05.03
34.
In Drosophila, the genes b, c, and sp are linked and arranged as shown below:
b——30 mu——c——20 mu——sp
This region exhibits 90% interference. How many double crossovers would be recovered in a three-point cross involving b, c,
and sp out of 1000 progeny?
A. 3
B. 6
C. 54
D. 60
E. 600
Bloom's: 4. Analyze
Section: 05.03
5-28
35. In tetrad analysis, the criterion for linkage of two genes is

A. NPD = T.
B. PD = T.
C. PD = NPD.
D. PD > NPD.
E. PD > T.
Learning Objective: 05.05.03 Describe how the relative numbers of PDs and NPDs can be used to establish linkage.
Section: 05.05
Topic: Tetrad Analysis in Fungi
36. In tetrad analysis, NPD asci result from

A. independent assortment of unlinked genes.
B. double crossovers between linked genes.
C. single crossovers between linked genes.
D. single crossovers between a gene and a centromere.
E. independent assortment of unlinked genes or double crossovers between linked genes.
Learning Objective: 05.05.02 Differentiate between parental ditype (PD), nonparental ditype (NPD), and tetratype (T).
Section: 05.05
37. In tetrad analysis, second-division segregations result from

A. single crossovers between linked genes.
B. double crossovers between linked genes.
C. single crossovers between a gene and a centromere.
D. independent assortment of unlinked genes.
E. nondisjunction of homologs.
Learning Objective: 05.05.01 Explain the meaning of relationship of the term "tetrad" to the asci produced by certain fungi.
Section: 05.05
5-29
38. Tetrad analysis shows that crossing over occurs at the four-strand stage (i.e., after
replication) because, when two genes are linked,
A. NPD > T.
B. T > NPD.
C. T > PD.
D. PD > NPD.
E. PD > T.
Learning Objective: 05.05.03 Describe how the relative numbers of PDs and NPDs can be used to establish linkage.
Section: 05.05
39. Sturtevant's detailed mapping studies of the X chromosome of Drosophila established

what genetic principle?
A. That genes are arranged in a linear order on the chromosomes.
B. That genes are carried on chromosomes.
C. That sex determination is controlled by the X and Y chromosomes.
D. That segregation of an allelic gene pair is accompanied by disjunction of homologous
chromosomes.
E. That different pairs of chromosomes assort independently.
Section: 05.02
5-30
40.
Suppose an individual is heterozygous for a pair of alleles (e.g., A/a). Under what conditions would a crossover in a somatic
cell of this individual lead to a clone of cells homozygous for a? (Pick the most precise answer.)
A.
The crossover would have to occur between the A locus and the centromere and involve two homologous (non-sister)
chromatids.
B.
The crossover would have to occur between the A locus and the end of the chromosome and involve two homologous (non-
sister) chromatids.
C.
The crossover would have to occur on the same chromosome arm as the A locus and involve two homologous (non-sister)
chromatids.
D.
The crossover would have to occur on the same chromosome as the A locus and involve two homologous (non-sister)
chromatids.
E.
The crossover would have to occur between the A locus and the centromere and involve two sister chromatids (not
homologous) chromatids.
Bloom's: 4. Analyze
Learning Objective: 05.06.01 Explain how mitotic recombination leads to the mosaic condition termed twin spots.
Section: 05.06
Topic: Mitotic Recombination and Genetic Mosaics
5-31
41.
If an individual is heterozygous at two loci (Ab/aB) which are on the same chromosome arm with the A locus closest the
centromere under what conditions would a crossover in a somatic cell generate a twin spot?
A.
The crossover would have to occur between the A locus and the centromere locus and involve two homologous (non-sister)
chromatids.
B.
The crossover would have to occur between the A locus and the B locus and involve two homologous (non-sister) chromatids.
C.
The crossover would have to occur between the B locus and the end of the chromosome locus and involve two homologous
(non-sister) chromatids.
D.
A double crossover would have to occur, with one crossover between the A locus and the centromere and a second crossover
between the A and B loci locus and both crossovers would have to involve two homologous (non-sister) chromatids.
E. No crossover in a somatic cell could generate a twin spot.
Bloom's: 4. Analyze
Section: 05.06
5-32
42.
Individuals heterozygous for the RB+ and RB- alleles can develop tumors as a result of
A.
a mitotic crossover that leads to homozygosity for both RB+ and RB-.
B.
a somatic mutation in the RB+ allele that leads to homozygosity for RB-.
C.
a somatic mutation in the RB- allele that leads to homozygosity for RB+.
D.
the fact that RB- is dominant to RB+.
E.
a mitotic crossover that leads to homozygosity for both RB+ and RB- and a somatic mutation in the RB+ allele that leads to
homozygosity for RB-.
Section: 05.06
5-33
43. What happens physically during the process of crossing over?

A. Two homologous chromatids break and rejoin at random sites along the chromosome.
B. The genetic information on one chromatid is replaced by copying genetic information from
a homologous chromatid without there being any physical exchange between the
chromosomes.
C. Two homologous chromatids break and rejoin at precisely the same site along the
chromosome so that there is no loss or gain of material on either product.
D. It is not known what occurs during crossing over.
Section: 05.02
44. Some of the larger human chromosomes typically contain multiple chiasmata during
meiotic prophase. If you were to carefully study the distribution of these chiasmata, what
would you find?
A. Chiasmata are randomly distributed along chromosomes.
B. All chromosome pairs have the same number of chiasmata.
C. A single chromosome pair always has the same number of chiasmata in every meiotic cell.
D. Chiasmata are spaced along a chromosome arm more regularly than would be expected by
chance.
E. Chiasmata are spaced more irregularly along a chromosome arm than would be expected
by chance.
Section: 05.02
5-34
45.
Which of the following types of tetrads contain two recombinant and two parental asci?
A.
PD only
B.
PD and NPD
C.
T only
D.
PD and T
E.
NPD and T
Section: 05.05
In Drosophila, singed bristles (sn) and carnation eyes (car) are both caused by recessive X-linked alleles. The wild-type
alleles (sn+ and car+) are responsible for straight bristles and red eyes, respectively. A sn car female is mated to a sn+ car+
male and the F1 progeny are interbred. The F2 are distributed as follows
sn car 55
sn car+ 45
sn+ car 45
sn+ car+ 55
200
5-35
46.
What is the 2 value for a test of the null hypothesis?
A. 0.5
B. 1.0
C. 2.0
D. 0.4
E. 20
Bloom's: 3. Apply
Section: 05.04
5-36
47.
What is the p value from this test? (Pick the most accurate choice.)
A.
p > 0.5
B.
0.1 < p < 0.5
C.
p < 0.1
D.
p < 0.05
E.
p < 0.01
Bloom's: 3. Apply
Section: 05.04
In humans, the genes for red-green color blindness (R = normal, r = color-blind) and hemophilia A (H = normal, h =
hemophilia) are both X-linked and only 3 map units apart.
5-37
48. Suppose a woman has four sons, and two are colorblind but have normal blood clotting
and two have hemophilia but normal color vision. What is the probable genotype of the
woman?
A.
HR / hr
B.
Hr / hr
C.
hr / hR
D.
Hr / hR
E.
HR / Hr
Bloom's: 4. Analyze
chromosome.
Section: 05.02
49. A woman whose mother is colorblind and whose father has hemophilia A is pregnant with
a boy and what is the probability that the baby will have normal vision and blood clotting?
A. 0.03
B. 0.15
C. 0.485
D. 0.47
E. 0.015
chromosome.
Section: 05.02
5-38
In Drosophila, the recessive pr and cn mutations cause brown and bright-red eyes, respectively (wild-type flies have brick-
red eyes). The double mutant pr cn combination has orange eyes. A female who has wild-type eyes is crossed to an orange-
eyed male. Their progeny have the following distribution of eye colors:
wild-type 8
brown 241
bright-red 239
orange 12
500
50. Which classes are the parental types?

A. wild-type and orange
B. brown and bright-red
C. wild-type and brown
D. bright-red and orange
E. There is no way to determine this.
Bloom's: 4. Analyze
Learning Objective: 05.01.04 Explain how a testcross can provide evidence for or against linkage.
Section: 05.01
5-39
51. What is the genotype of the mother of these progeny?

A.
pr cn / pr+ cn+
B.
pr+ cn / pr+ cn
C.
pr+ cn / pr cn+
D.
pr cn+ / pr cn+
E.
pr cn / pr cn
Bloom's: 4. Analyze
Section: 05.01
5-40
52. The mother of these progeny resulted from a cross between two flies from true breeding
lines. What are the genotypes of these two lines?
A.
pr pr cn+ cn+ and pr+ pr+ cn cn
B.
pr+ pr+ cn+ cn+ and pr pr cn cn
C.
pr+ pr cn+ cn and pr pr cn cn
D.
pr+ pr cn cn and pr pr cn+ cn
E.
Either pr pr cn+ cn+ and pr+ pr+ cn cn or pr+ pr+ cn+ cn+ and pr pr cn cn could be true.
Bloom's: 4. Analyze
Section: 05.01
53.
What is the map distance between the pr and cn genes?
A. 20 m.u.
B. 2 m.u.
C. 4 m.u.
D. 46 m.u.
E. 8 m.u.
Bloom's: 4. Analyze
Section: 05.01
5-41
Consider a pair of homologous chromosomes heterozygous for three genes (e.g. ABC / abc) during prophase I of meiosis. Let
the sister chromatids of one homolog be numbered 1 and 2; and the sister chromatids of the other homolog be numbered 3
and 4.
54.
A crossover that would result in genetic recombination (e.g., Abc or aBC) could involve which chromatids?
A. 1 & 2 or 3 & 4
B. 1 & 3 or 2 & 4
C. 1 & 4 or 2 & 3
D. 1 & 3 or 1 & 4 or 2 & 3 or 2 & 4
E. any two of the four chromatids
Bloom's: 4. Analyze
Section: 05.02
55.
Assume a double crossover occurs in this pair of chromosomes that results in chromatids of the genotype AbC and aBc. If the
first crossover (the one between A and B) involves chromatids 1 & 4, which chromatids could be involved in the second
crossover?
A. 1 & 2 or 3 & 4
B. 1 & 3 or 2 & 4
C. 1 & 4 or 2 & 3
D. 1 & 3 or 1 & 4 or 2 & 3 or 2 & 4
E. any two of the four chromatids
Bloom's: 4. Analyze
Section: 05.02
5-42
In a mating between haploid yeast cells of type a = his4/TRP1  type  = HIS4/trp1, a/ diploid offspring result. Match the
appropriate ditype that results when these undergo meiosis with the genotypes shown: parental (PD), non-parental (NPD), or
tetratype (T).
56.
his4/TRP1; his4/trp1; HIS4/trp1; HIS4/TRP1
A.
PD
B.
NPD
C.
T
D.
Bloom's: 4. Analyze
Section: 05.05
5-43
57.
his4/TRP1; his4/TRP1; HIS4/trp1; HIS4/trp1
A.
PD
B.
NPD
C.
T
D.
Bloom's: 4. Analyze
Section: 05.05
5-44
58.
his4/trp1; his4/trp1; HIS4/TRP1;HIS4/TRP
A.
PD
B.
NPD
C.
T
D.
Bloom's: 4. Analyze
Section: 05.05
5-45
59.
HIS4/trp1; HIS4/TRP1; his4/TRP1; his4/trp1
A.
PD
B.
NPD
C.
T
D.
Bloom's: 4. Analyze
Section: 05.05
5-46
60.
HIS4/trp1; HIS4/trp1; his4/TRP1; his4/TRP1
A.
PD
B.
NPD
C.
T
D.
Bloom's: 4. Analyze
Section: 05.05
Match the following results of offspring in an ordered octad with the appropriate segregation pattern: first-division or second
division.
5-47
61.
ws; ws; ws; ws; ws+; ws+; ws+; ws+
A.
First-division segregation pattern
B.
Second-division segregation pattern
Bloom's: 4. Analyze
Learning Objective: 05.05.04 Explain how ordered and unordered tetrad analysis can map the positions of genes and (for ordered tetrads)
centromeres.
Section: 05.05
62.
ws; ws; ws+; ws+; ws; ws; ws+; ws+
A.
B.
Bloom's: 4. Analyze
centromeres.
Section: 05.05
5-48
63.
ws; ws; ws+; ws+; ws+; ws+; ws; ws
A.
B.
Bloom's: 4. Analyze
centromeres.
Section: 05.05
64.
ws+; ws+; ws+; ws+; ws; ws; ws; ws
A.
B.
Bloom's: 4. Analyze
centromeres.
Section: 05.05
5-49
65.
ws+; ws+; ws; ws; ws+; ws+; ws; ws
A.
B.
Bloom's: 4. Analyze
centromeres.
Section: 05.05
True / False Questions
66. Two genes are considered linked when F2 progeny more commonly show the recombinant
genotype.
FALSE
Section: 05.01
67. Chiasmata are structures of cross over between sister chromatids of homologous
chromosomes.
FALSE
Section: 05.02
5-50
68. Chiasmata can be seen through a light microscope and are sites of recombination.
TRUE
Section: 05.02
69. A linkage group can be defined as genes that may be so far apart on a chromosome that
they cannot be shown to be linked directly but they can be shown to be on the same
chromosome due to their linkage with other genes.
TRUE
Learning Objective: 05.03.04 Describe the relationship between linkage groups and chromosomes.
Section: 05.03
70.
The hypothesis that predicts no linkage between genes is known as the null hypothesis.
TRUE
Learning Objective: 05.04.02 Discuss the concept of the null hypothesis and its use in data analysis.
Section: 05.04
71.
If the p value corresponding to a given 2 value and number of degrees of freedom exceeds 0.05, then the null hypothesis is
rejected and it is predicted that the two genes being evaluated are not linked.
TRUE
Learning Objective: 05.04.02 Discuss the concept of the null hypothesis and its use in data analysis.
Section: 05.04
5-51
72.
Genes that are not syntenic are not linked.
TRUE
Learning Objective: 05.01.01 Define linkage with respect to gene loci and chromosomes.
Section: 05.01
73.
The length of an entire linkage group or chromosome may exceed 50 mu because the map distance is calculated from the
addition of the distance between many gene pairs.
TRUE
Learning Objective: 05.03.04 Describe the relationship between linkage groups and chromosomes.
Section: 05.03
74.
In an ordered octad, every spore is adjacent to at least one spore that is genetically identical to itself.
TRUE
centromeres.
Section: 05.05
5-52
75.
Sectors with a different phenotype in an otherwise uniform yeast colony may be evidence of mitotic recombination.
TRUE
Learning Objective: 05.06.02 Describe sectored colonies in yeast and their significance in evaluating mitotic recombination.
Section: 05.06
76.
Large sectors suggest a mitotic recombination event late in the growth of a yeast colony.
FALSE
Learning Objective: 05.06.02 Describe sectored colonies in yeast and their significance in evaluating mitotic recombination.
Section: 05.06
77.
Fungi that produce tetrads typically grow as haploids but can undergo sexual reproduction by combining different mating
types.
TRUE
centromeres.
Section: 05.05
5-53
78.
A female mouse from a true-breeding wild-type strain was crossed to a male mouse with apricot eyes (ap) and grey body
(gy). The F1 mice were wild-type for both traits. When the F1 were interbred, the F2 were distributed as follows:
Females all wild type 200

wild type 91
apricot 11
Males
grey 9
apricot, grey 89
Which of the following statements is correct?
A.
ap and gy are unlinked.
B.
ap and gy are linked on an autosome and 10 map units apart.
C.
ap and gy are linked on an autosome and 20 map units apart.
D.
ap and gy are X-linked and 10 map units apart.
E.
ap and gy are X-linked and 20 map units apart.
Bloom's: 4. Analyze
Section: 05.01
5-54
79.
Suppose the map for a particular human chromosome interval is:
a——1 mu——b——1 mu——c——1 mu——d——1 mu——e——1 mu——f
In a man heterozygous for all six genes, what fraction of his sperm would be recombinant in the a-f interval?
A.
0%
B.
1%
C.
2.5%
D.
5%
E.
Bloom's: 3. Apply
Section: 05.01
True / False Questions
5-55
80.
A coefficient of coincidence of 0.5 in a region of three genes means that half as many double crossovers were observed as
would have been expected if crossovers in the two intervals were independent.
TRUE
Section: 05.03
81.
Mitotic recombination occurs between homologous chromosomes. In which of the following would you not expect to
encounter mitotic recombination?
A.
E. coli
B.
Tobacco plants
C.
Homo sapiens
D.
Drosophila melanogaster
Bloom's: 3. Apply
Section: 05.06
5-56
82.
The locus B on the X chromosome of a malaria-carrying mosquito shows a 49% recombination rate with respect to the locus
M. Since a recombination rate of 50% is essentially indistinguishable from independent assortment, you might be tempted to
look for a locus that falls between B and M. Before you decide to do all that work, you run a chi-square test to determine the
p value of your experiment. Which of the following p values would be most likely to tell you that you should accept the
conclusion that locus B and locus M are, indeed, 49 mu apart and that another locus is not necessary?
A.
p = 0.45
B.
p = 0.07
C.
p = 0.05
D.
p = 0.0007
Bloom's: 3. Apply
Section: 05.04
5-57
83.
In ascomycete fungi, the arrangement of the spores in the ascus that directly reflects the order in which they were produced
during meiosis is called an ______.
A. Unordered tetrad
B. Unordered octad
C. Ordered tetrad
D.
Ordered pentad
Learning Objective: 05.05.01 Explain the meaning of relationship of the term "tetrad" to the asci produced by certain fungi.
Section: 05.05
84. Twin spotting provides evidence of what genetic event?

A. Meiotic recombination
B. Mitotic recombination
C. Linkage
D. Mutation
E. Biological evolution
Section: 05.06
85. Another name for a chromosome is a _______, since it contains genes that are often
inherited together.
A. linkage group
B. crossing over group
C. genetic recombinant
D. bivalent
Section: 05.03
5-58
86. The diploid garden pea plant has 14 chromosomes. The haploid fungus Neurospora
crassa has 7 chromosomes. Neither organism has separate male and female
individuals. Therefore, the number of linkage groups in these two organisms is:
A. Garden pea has 14 linkage groups, and Neurospora has 7.
B. Garden pea has 7 linkage groups, and Neurospora has 7.
C. Garden pea has 8 linkage groups, and Neurospora has 8.
D. Gardent pea has 15 linkage groups, and Neurospora has 8.
Bloom's: 3. Apply
Topic: Genetic Mapping In Plants And Animals
Topic: Overview Of Linkage
87.
The number of linkage groups in an organism with sex chromosomes equals:
A.
1n
B.
2n +1
C.
1n + 1
D.
2n + 2
Bloom's: 3. Apply
5-59
88.
The number of linkage groups in a species that does not have sex chromosomes is:
A.
1n
B.
1n + 1
C.
2n
D.
2n + 2
Bloom's: 3. Apply
5-60

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Chapter 05 - Linkage, Recombination, and the Mapping of Genes on Chromosomes

Solution Manual for Genetics From Genes to Genomes

Multiple Choice Questions

What is the coefficient of coincidence in this region?

Which of the three genes is in the middle?

Calculate the coefficient of coincidence in this region.

tall, red, wide 381

What is the genotype of the tall, red, wide-leaved parent?

Which of the three genes, if any, is unlinked to the others?

How many degrees of freedom are there?

Which statement(s) below apply to the concept of gene linkage?

What is the map distance between sn and ct?

24. Recombination frequencies near 50% suggest that

26. Which of the following processes can generate recombinant gametes?

Q——10 mu——R——40 mu——S

C. The ratios would be the same in the two intervals.

The map of a chromosome interval is:

A——10 mu——B——40 mu——C

b——30 mu——c——20 mu——sp

35. In tetrad analysis, the criterion for linkage of two genes is

36. In tetrad analysis, NPD asci result from

37. In tetrad analysis, second-division segregations result from

39. Sturtevant's detailed mapping studies of the X chromosome of Drosophila established

E. No crossover in a somatic cell could generate a twin spot.

43. What happens physically during the process of crossing over?

What is the 2 value for a test of the null hypothesis?

50. Which classes are the parental types?

51. What is the genotype of the mother of these progeny?

pr pr cn+ cn+ and pr+ pr+ cn cn

What is the map distance between the pr and cn genes?

his4/TRP1; his4/trp1; HIS4/trp1; HIS4/TRP1

his4/TRP1; his4/TRP1; HIS4/trp1; HIS4/trp1

his4/trp1; his4/trp1; HIS4/TRP1;HIS4/TRP

HIS4/trp1; HIS4/TRP1; his4/TRP1; his4/trp1

HIS4/trp1; HIS4/trp1; his4/TRP1; his4/TRP1

ws; ws; ws; ws; ws+; ws+; ws+; ws+

ws; ws; ws+; ws+; ws; ws; ws+; ws+

ws; ws; ws+; ws+; ws+; ws+; ws; ws

ws+; ws+; ws+; ws+; ws; ws; ws; ws

ws+; ws+; ws; ws; ws+; ws+; ws; ws

True / False Questions

Genes that are not syntenic are not linked.

Multiple Choice Questions

Females all wild type 200

Which of the following statements is correct?

Suppose the map for a particular human chromosome interval is:

a——1 mu——b——1 mu——c——1 mu——d——1 mu——e——1 mu——f

True / False Questions

Multiple Choice Questions

84. Twin spotting provides evidence of what genetic event?

The number of linkage groups in an organism with sex chromosomes equals:

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