河北玉星生物工程有限公司
HEBEI YUXING BIO-ENGINEERING CO., LTD.
地址：河北省宁晋县西城区 Add:XiCheng district Ningjin county, Hebei province,
电话 Tel: 0086-319-5808191 Fax: 0086-319-5808191, 0086-319-5801619

Cyanocobalamin（USP）

Description
Cyanocobalamin is a dark-red, crystalline powder or dark-red crystals.
Odorless and tasteless.
Sparingly soluble in water and in alcohol, practically insoluble in acetone. The
anhydrous substance is very hygroscopic.

Product identification
Chemical names:
α-(5,6-dimethylbenzimidazol-1-yl) cobamide cyanide
Synonyms: Vitamin B12 ; Cobinamide cyanide phosphate 3’-ester with
5,6-dimethyl-　-D-ribofuranosylbenzimidazole inner salt
CAS No.: [68-19-9]
Molecular formula: C63H88CoN14O14P
Relative molecular mass: 1355

Specifications
Appearance: dark-red, crystalline powder or dark-red crystals.
Identification: A : A361/A278=1.70 to 1.90
A361/A550=3.15 to 3.40
B : Meets USP monography requirements
C : Meets USP monography requirements
Loss on drying: ≤ 10%
Pseudo cyanocobalamin : Meets USP monography requirements
PH: 4.2-7.0
Residual acetone: ≤5000ppm
Assay: 97-100.5%
Total plate count: ≤800CFU/g
Total molds yeasts: ≤80CFU/g
E.coli: Negative
Solubility
Sparingly soluble in water and in alcohol, practically insoluble in acetone.

Stability and storage

Cyanocobalamin is fairly stable if Preserved in tight, light-resistant containers, and stored at
controlled room temperature. The product may be stored for 36 months from the date of
manufacture in the unopened original container and at controled room temperature.
It has little change on the conditions of light and high temperature, but the impurities
increase under alkaline, acid and oxidation conditions. The anhydrous substance is very
hygroscopic, so the loss on drying will increase after open the containers without suitable
protected measures. But that doesn’t affect the biological activity.
  河北玉星生物工程有限公司
HEBEI YUXING BIO-ENGINEERING CO., LTD.
地址：河北省宁晋县西城区 Add:XiCheng district Ningjin county, Hebei province,
电话 Tel: 0086-319-5808191 Fax: 0086-319-5808191, 0086-319-5801619
Uses
For the enrichment of food products.
For solid multivitamin and monovitamin preparations.
For the production of food additive
The purchaser assumes all responsibility for additional processing, testing, labelling and
registration required for such use.

Compendia compliance
Cyanocobalamin meets all requirements of the USP. when tested according to the compendia.

Safety
This product is safe for the intended use. Avoid ingestion, inhalation of dust or direct
contact by applying suitable protective measures and personal hygiene. For full safety
information and necessary precautions, please refer to the respective Material Safety Data
Sheet.

Date of adoption
03/02/2017