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INT J TUBERC LUNG DIS 19(12):1441–1447

Q 2015 The Union


http://dx.doi.org/10.5588/ijtld.14.0888

Computerised tomography and intravenous pyelography in


urinary tuberculosis: a retrospective descriptive study

Y. Wang,* J-P. Wu,† G-C. Qin,* D-Y. Li,* Z-P. Zhou,* X. Dou,* B. Zhu,* H-Q. Guo†
Departments of *Radiology, and †Urology, the Affiliated Nanjing Drum Tower Hospital of Nanjing University
Medical School, Nanjing, China

SUMMARY

OBJECTIVE: To assess the radiological findings of 81.4% of the destructive renal lesions identified in the
urinary tuberculosis (TB) in patients from multiple medulla. The numbers of lesions in the dorsal medulla
centres to improve understanding of this disease among and the lower pole of the renal medulla were greater
urologists and radiologists. than those in the ventral, middle and upper poles (P ¼
M A T E R I A L S A N D M E T H O D S : A total of 192 consecu- 0.0361).
tive patients (98 males and 94 females) with urinary TB C O N C L U S I O N : Hydronephrosis is a frequently ob-
underwent computed tomography; 28 of the 192 also served radiological finding among patients with urinary
underwent contrast agent-enhanced intravenous pyelog- TB. Most TB lesions were observed in the renal medulla,
raphy of the kidney, ureter and bladder (KUB/IVP). especially the dorsal and lower poles of the medulla.
R E S U LT S : The most common finding was hydrone- K E Y W O R D S : radiological features; urinary TB; imag-
phrosis, observed in 79.1% of the patients, with ing

THE URINARY SYSTEM is one of the most understanding of this disease among urologists and
common sites of extra-pulmonary tuberculosis radiologists.
(TB).1,2 As urinary TB has various clinical charac-
teristics and is often misdiagnosed,3 the early MATERIALS AND METHODS
diagnosis of the condition would be helpful in
rescuing kidney function.4,5 Minimal attention has Institutional review board approval was obtained for
been devoted to the diagnosis of urinary TB using this retrospective study at all participating sites; the
imaging techniques, and a systematic approach to its need for informed consent was waived as the study
clinical diagnosis has not yet been established.2,6 was based on patient records.
With recent improvements in imaging technology,
Patient population
imaging findings could be used to support the
diagnosis of urinary TB.7 Characteristic kidney, This retrospective analysis was based on patient data
collected from five hospitals: four in Jiangsu Province
ureter and bladder signs as observed using intrave-
and one in Zhejiang Province, China. Between
nous pyelography (kidney, ureter, bladder/intrave-
January 2007 and April 2014, a total of 192
nous pyelography [KUB/IVP]) and computed
consecutive urinary TB patients who had undergone
tomography (CT) are useful in identifying urinary
contrast-enhanced KUB/IVP, CT or both were con-
TB.7 However, radiographic findings of early uri-
sidered for inclusion in the study. Exclusion criteria
nary TB are often non-specific and are of limited included upper urinary tract tumours or stones and a
diagnostic value.8–10 No systematic descriptions of history of urinary tract trauma. Participation of
urinary TB based on imaging characteristics in large hospitals in the study was voluntary. The final
samples have been reported. selection reflected a good mixture of centres located
We performed a retrospective study of a large in both Nanjing and Ningbo, including academic and
sample of patients with urinary TB to more general hospitals as well as small and large centres
precisely evaluate urinary TB and promote a better with dedicated radiology departments.
Patients were selected using a database search of
WY, JPW, QG, LD, ZZP and XD are co-first authors. medical records. A final 192 patients formed the basis

Correspondence to: Hongqian Guo, Department of Urology, the Affiliated Nanjing Drum Tower Hospital of Nanjing
University Medical School, 321 Zhongshan Road, Nanjing 210008, China. Tel: (þ86) 025 8310 6666. Fax: (þ86) 025 8331
7016. e-mail: guohongqiang2014@163.com
Article submitted 25 November 2014. Final version accepted 18 June 2015.
1442 The International Journal of Tuberculosis and Lung Disease

of this report. A total of 98 males and 94 females, rectomy) and direct manifestations (renal swelling,
ranging in age from 16 to 92 years (mean 46.3 years destructive lesions and repair manifestations). The
6 standard deviation [SD] 16.6) were enrolled in the frequency of each finding on KUB/IVP and CT was
study. Urinary TB was confirmed in all 192 patients recorded.
and diagnosed using urine acid-fast staining or
culture (n ¼ 103) or by histological examination of KUB/IVP and CT image analysis
surgical specimens (n ¼ 89). All of the patients All KUB/IVP and CT images were independently
underwent surgery after imaging. reviewed in a random order by two radiologists (YW
and BZ), with respectively 10 and 32 years of
Imaging techniques experience. The observers were notified of the
KUB/IVP images locations of the lesions but were blinded to all other
KUB/IVP was performed on 28 patients using the information. Three image sets were reviewed as
kVp, mA and geometrical parameter values of the follows: KUB/IVP images alone, thin-slice CT images
standard protocol provided with the simulated digital alone and KUB/IVP plus thin-slice CT images. First,
diagnostic X-ray system (Philips Healthcare, Eind- the KUB/IVP images alone and the thin-slice CT
hoven, The Netherlands). All of the KUB/IVP studies images alone were interpreted, in that order; the
were recorded using a picture archiving and commu- KUB/IVP plus thin-slice CT images were then
nication system (PACS) recorder for subsequent over- evaluated after an interval of 2 weeks.
reading. With the patient in the prone position, both
kidneys were visualised on KUB. The clinical history Statistical analysis
and KUB findings were interpreted, and a prospective KUB/IVP and CT findings were compared using the
diagnosis was made and recorded. IVP was then McNemar test as appropriate, and P values of ,0.05
performed on all of the patients. A 100-ml IV bolus of were considered statistically significant. The KUB/
non-ionic contrast material (Omnipaque 350; GE IVP and CT study patterns with multiple findings
Healthcare, Milwaukee, WI, USA) was administered were further analysed. Multiple findings on KUB/IVP
followed by radiography at 1, 5, 10, 15 and 20 min. or CT were classified as the presence of a single
Post-void and delayed films were obtained if indicat- imaging finding at multiple locations or the presence
ed. of multiple co-existing imaging findings.

CT images
RESULTS
All CT examinations were performed using a 16- and
64-slice GE CT system (GE Healthcare) or a 16- and Image quality analysis
64-slice Philips CT system (Philips Healthcare). All KUB/IVP findings
scans were performed using a helical technique, and The most common findings on KUB/IVP were
images were obtained using the following parameters: hydrocalycosis, hydronephrosis or hydroureter due
a single breath-hold; 1.25 or 1.75 mm collimation, to stricture in 54.8% of the patients (15/28 patients),
gantry rotation speed of 0.5 s, a pitch of 1.0, 1.25 or autonephrectomy in 18.7% (5/28 patients) and
1.5 mm reconstruction; 120 kVp; 250 mA; a 512 3 urinary tract calcifications in 26.3% (7/28 patients)
512 matrix; and a display field-of-view of 25 cm. The (Figure 1A). Interobserver agreement between the
non-ionic contrast agent iohexol (Omnipaque 350) two readers on a per-patient basis showed a j value of
was injected with a power injector at a rate of 3.0 ml/s 0.75, representing substantial agreement.
through the marginal vein using a 20-gauge needle at
a dose of 1.0 ml/kg. CT was started 30 s after the CT findings
injection. Axial images were reconstructed using the The frequency of imaging findings on CT in the 192
standard algorithm. Image quality was assessed patients is given in the Table. Hydrocalycosis,
paying particular attention to visualisation of the hydronephrosis or hydroureter due to stricture was
renal parenchyma, ureter and bladder with medias- the most common finding in 79.1% of the patients
tinal window settings (window width, 400 H; (151/192 patients) (Figure 1B), followed by paren-
window level, 65 H). chymal scarring in 67.6% (130/192 patients), renal
All 192 patients were examined using CT, 28 of swelling in 54.8% (105/192 patients) (Figure 1C),
whom were also examined using KUB/IVP. The KUB/ and thickening of the renal pelvis, ureter and bladder
IVP and CT findings were reviewed by two radiolo- walls in 23.1% (44/192 patients) (Figure 1D). In
gists. To determine the accuracy of the KUB/IVP and long-standing TB with atrophy of the renal paren-
CT diagnoses, a consensus interpretation of the chyma, normal kidney morphology is lost (Figure
imaging findings was accepted. We assessed the 1C). A total of 92.0% (177/192) of renal TB cases
presence and frequency of certain findings on KUB/ involved a single kidney (Figure 1A, B; Figure 2A, C,
IVP and CT, including indirect manifestations (hy- D; and Figure 3A, B). Renal TB in the right or left
dronephrosis, poorly staining kidney and autoneph- kidney was found at a rate of respectively 51.2% (91/
Features of urinary TB on CT 1443

Figure 1 Hydronephrosis and hydroureter in a 42-year-old man (A and B) and hydronephrosis, swelling, atrophy and a thickened
urinary tract wall in a 71-year-old man (C and D). A) The marked left hydronephrosis and hydroureter are revealed by IVP imaging
(white arrow). B) The marked left hydroureter (white arrow) and necrotic tissue are shown on abdominal axial-enhanced CT. C)
Bilateral hydronephrosis (arrow and arrowhead), left renal swelling and right atrophy are shown on CT imaging. The renal medulla
lesion in the lower pole is clear (arrowhead). D) The axial-enhanced CT image shows circumferential ureteral wall thickening (arrow).
IVP ¼ intravenous pyelography; CT ¼computed tomography.

177) and 48.8% (86/177) (P ¼ 0.6102; Table). Only 2A). Destructive forms of circular or quasi-circular
8.0% (15/192) of renal TB cases were bilateral abscess cavities with diameters ranging from 0.8 to
(Figure 1C). 3.4 cm could be detected on CT. However, some
In our study, 89.1% (171/192) of the patients details of the features of these lesions could be easily
presented with poorly staining kidneys in the cortico- overlooked on KUB/IVP images. The number of
medullary and parenchymal phases. Characteristic major lesions in the dorsal medulla was larger than
early washout during the arterial and early cortico- that in the ventral medulla, and these lesions
medullary phases served as differential criteria accounted for respectively 68.2% (393/576) and
against other inflammatory lesions (Figure 2A). 31.8% (183/576) of the total number of lesions (P
Calcifications were noted in patients with healed or , 0.05; Figure 3A). The number of major lesions in
chronic TB (Figure 2). Renal calcifications in renal the lower pole of the renal medulla was greater than
parenchyma were identified on CT in 123 cases. The in the middle and upper poles, and these lesions
final outcome of inadequately treated TB is dystro- accounted for respectively 50.5% (291/576), 36.7%
phic calcification involving both kidneys, known as (211/576) and 12.8% (74/576) of the total lesions (P
‘putty kidney’ (Figure 2D). , 0.05; Figure 3B, Table).
Our results showed that 81.4% (156/192) of the When the renal pelvis and ureter showed TB
destructive renal lesions of end-stage renal TB were involvement, hydronephrosis was considered to be
identified in the medulla (Figure 1B and C and Figure severe. The involved segments showed wall thicken-
1444 The International Journal of Tuberculosis and Lung Disease

Table Imaging findings on computed tomography ing and enhancement on CT (Figure 1D). Multiple
Imaging finding n/N (%) strictures were commonly observed in the ureters on
CT images. Our results show a rate of ureteral
Indirect manifestations
Hydronephrosis 152/192 (79.1) calcification of 26.3% (50/192); renal calcification
Poorly staining kidney 129/192 (67.6) was the most common form in 58.8% (113/192) of
Autonephrectomy 36/192 (18.7)
patients (Figure 2C and D).
Direct manifestations
Renal swelling 146/192 (76.2)
Location of destructive lesions
Left kidney 98/192 (48.8)
DISCUSSION
Right kidney 94/192 (51.2)
Renal medulla 156/192 (81.4) KUB/IVP and CT are the two most commonly used
Upper 24/192 (12.8) methods for urinary TB imaging.7 The accuracy of
Middle 70/192 (36.7)
Lower 97/192 (50.5)
KUB/IVP in the diagnosis of urinary TB is 88%.11
Dorsal 131/192 (68.2) The earliest urographic change occurs in the minor
Ventral 61/192 (31.8) calyces, with subtle initial signs such as minimal
Repair manifestation calyceal dilatation.12 As the disease progresses, the
Nephrotic 130/192 (67.6)
Renal calcification 112/192 (58.8) calyceal outline becomes more irregular, fuzzy and
Ureteral calcification 50/192 (26.3) ragged, subsequently becoming feathery and ‘moth-
eaten’ in appearance. Although calyceal erosion has
been described as the first KUB/IVP sign in renal

Figure 2 Comparison of destructive lesion in a 40-year-old woman (A and B) and pathological repair in a 70-year-old woman (C)
and a 58-year-old woman (D). A) Focal hypoperfusion of the right kidney was observed on axial-enhanced CT (white arrow). B) The
low-power photomicrograph (haematoxylin-eosin staining; original magnification, 40x) shows renal TB with focal-caseating
granulomas, glomerular hyalinisation and sheets of chronic interstitial inflammation. C) The non-enhanced image reveals the presence
of small areas of calcification in the left kidney (arrow). D) The non-enhanced image depicts dense calcification replacing the right
kidney (arrow). CT ¼ computed tomography.
Features of urinary TB on CT 1445

Figure 3 Accurate renal parenchymal cavities on oblique-enhanced CT in a 62-year-old woman (A) and a 47-year-old man (B). A)
The contrast-enhanced image shows that the caseous necrosis in the dorsal medulla is larger than that in the ventral medulla (arrows).
B) The contrast-enhanced image shows that the large caseous necrosis in the lower pole is much larger than those in the middle and
upper poles of the renal medulla (arrow). CT ¼computed tomography.

TB,12 in the authors’ opinion early papillary necrosis during the early stage of renal TB. We estimate that
may be the first detectable sign in practice. as this process progresses, survival may be ensured by
From 2007 to 2014, the primary morphological as yet unidentified compensatory mechanisms. Addi-
changes in patients with renal TB were hydronephro- tional investigations into this area are therefore
sis (79.1%) and renal swelling (76.2%) (Figure 2A, needed.
Table). Hydronephrosis is considered to be severe In addition to the repair characteristics of the
when the renal pelvis and ureter are involved. Wall involved kidney, another common manifestation of
thickening and post-contrast enhancement can be urinary TB is uneven renal parenchymal calcifica-
observed in the involved segment of the collecting tions.7 Triangular ring-like calcifications characteris-
system.13 The progression of urinary TB can be tic of papillary necrosis may be noted within the
described according to its initial haematogenous collecting system and in the lower pole of the kidney
dissemination, reactivation and destructive spread, (Figure 2). These results may be explained by the fact
which can be correlated with the pathogenesis of that TB is a chronic inflammatory infectious disease
inflammation, tissue swelling significantly earlier caused by interactions between tissue injury and
than tissue atrophy and scar formation.14 During repair mechanisms. Muttarak et al. have reported
the late phase of renal TB, histopathological exam- that calcification is detectable in a large number of
ination revealed varying degrees of mixed inflamma- cases (40–70%);19 this varies in appearance depend-
tory cell infiltration and tissue necrosis (Figure 2B). ing upon the stage and severity of the disease, from
Engin et al. and Das et al. reported that localised punctate areas to amorphous areas to thin rims
tissue oedema and vasoconstriction caused by active surrounding low-attenuation areas of focal cortical
inflammation result in focal hypoperfusion, as inflammation. Calcification may also be noted in
observed on contrast-enhanced CT.15,16 patients with healed or chronic TB.15,20
In our patients, we found that most of the renal TB During the early stages of urinary TB, a few calices
cases had single kidney involvement. Similar results are involved, and only papillary necrosis or calyceal
were also reported by Ballesteros et al. and Chowd- deformity are depicted on imaging studies.21 Our
hury.17,18 One possible reason why TB would affect results showed that most of the destructive renal
only one kidney is the possible trapping of Mycobac- lesions of TB are located in the medulla (Table). In
terium tuberculosis in periglomerular capillaries TB cases, papillary necrosis results not only from
1446 The International Journal of Tuberculosis and Lung Disease

ischaemia, which is the basis of change in most cases Acknowledgements


of renal papillary necrosis, but also as a result of Financial support for the study came from the National Natural
direct tissue destruction. Medullary cavitation with Science Foundation of China, Beijing (Grant no. 81400702), and
communication with the collecting system has been the Medical Technology Development Project of Nanjing, Nanjing,
described as a frequent finding by Kollins et al.22 China (Grant nos. YKK13062). The authors wish to thank X
Zheng for his commenets.
This cavitation may involve one or more papillae Conflicts of interest: none declared.
unilaterally or bilaterally, and it can vary in
appearance from small and smooth to large and
irregular;22 however, the incidence rate has not been References
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2 Nakane K, Yasuda M, Deguchi T, et al. Nationwide survey of
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Features of urinary TB on CT i

RESUME
O B J E C T I F : Evaluer les constatations radiologiques de plus fréquente faite chez 79,1% des patients. De plus,
la tuberculose (TB) urinaire chez des patients dans de 81,4% des lésions destructives rénales ont été identifiées
nombreux centres pour promouvoir une meilleure dans la medulla. Le nombre de lésions dans la medulla
compréhension de la maladie par les urologistes et les dorsale et le pôle inférieur de la medulla rénale a été plus
radiologistes. élevé que dans les pôles ventral, moyen et supérieur (P ¼
M A T E R I A L S E T M É T H O D E : Un total de 192 patients 0,0361).
consécutifs (98 hommes et 94 femmes) atteints de TB C O N C L U S I O N : L’hydronéphrose est une constatation
urinaire a eu un balayage tomodensitométrie, et 28 radiologique très fr équemment observ ée chez les
autres sur les 192 ont eu un examen avec produit de patients qui ont une TB urinaire. De plus, la majorité
contraste du rein, de l’uretère, de la vessie avec des lésions TB ont été observées dans la medulla rénale,
myélographie (KUB/IVP). surtout dans son pôle dorsal et inférieur.
R É S U LT A T S : L’hydronéphrose a été la constatation la

RESUMEN
O B J E T I V O: Evaluar los hallazgos radiográficos en los hidronefrosis, presente en el 79,1% de los pacientes.
casos de tuberculosis (TB) urinaria en varios centros, Además, el 81,4% de las lesiones destructivas del
con el propósito de mejorar la comprensión de esta parénquima renal se localizó en la médula. Las lesiones
enfermedad por parte de los urólogos y los radiólogos. de la médula dorsal y el polo inferior de la médula renal
P A C I E N T E S Y M É T O D O S: Se practicó una tomografı́a fueron más numerosas que las lesiones ventrales, medias
axial computarizada a 192 pacientes consecutivos (98 o del polo superior (P ¼ 0,0361).
hombres y 94 mujeres) con diagnóstico de TB urinaria; C O N C L U S I Ó N: La hidronefrosis es la anomalı́a
además, en 28 de los 192 pacientes se llevó a cabo una radiográfica observada con mayor frecuencia en los
pielografı́a intravenosa con contraste y realce del riñón, pacientes con TB urinaria. La mayor parte de las lesiones
el uréter y la vejiga (KUB/IVP). tuberculosas se observó en la médula renal, sobre todo
R E S U L T A D O S: El hallazgo más frecuente fue la en su parte dorsal y el polo inferior.

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