= © studocu Q MCQ in General pharmacology Pharmacokinetics is: a) The study of biological and therapeutic effects of drugs b) The study of absorption, distribution, metabolism and excretion of drugs ©) The study of mechanisms of drug action 4d). The study of methods of new drug development ‘What does “pharmacokinetics” include? a) Pharmacological effects of drugs b) Unwanted effects of drugs ©) Chemical structure of a medicinal agent XU) Dist ‘The main mechani ution of drugs in the organism m of most drugs absorption in GI tract is: a) Active transport (carrier-mediated diffusion) 1) Filtration (aqueous diffusion) ©) Endocytosis and exocytosis d) Passive diffusion (lipid diffusion) What does the term “bioayailabi a) Plasma protein binding degree of substance b) Permeability through the brai ©) Fraction of an uncharged di circulation following any route admi 4) Amount of a substance in urine relative to the initial doze Pick out the appropriate alimentary route of ad ration when passage of drugs through liver is minimized: a) Oral b) Transdermal ©) Reetal 4) Intraduodenal oO 1 out of 13 ft ii Home University High School Books studocu.com= © studocu Q MCQ in General pharmac... © im Which route of drug administration is most likely to lead to the first-pass effect? a) Sublingual by) Oral ©) Intravenous d) Intramuscular What is characteristic of the oral route? a) Fast onset of fect b} Absorption depends on GI tract secretion and motor function ©) A drug reaches the blood passing the liver 4} The sterilization of medicinal forms is obligatory the feature of the sublingual ute: a) Pretty fast absorption 'b) A drug is exposed to gastric secretion ©) A drug is exposed more prominent liver metabolism, ) A drug can be administrated in a variety of dos. Pick out the parenteral route of medicinal agent administration: a) Rectal by Oral ©) Sublingual 4) Inhat Parenteral administration: a) Cannot be used with unconsciousness patients b). Generally results in a less accurate dosage than oral administration ©) Usuallly produces a nore rapid response thran oval administration d) Is too slow for emergency use ‘What is characteristic of the intramuscular route of drug administration? a. Only water solutions can be injected b. Oily solutiony ean be injected ©. Opportunity of hypertonic solution injections d. Thea ion develops slower, than at oral administration oO 2 out of 13 ft ii Ee) Ga iu Home University High School Books studocu.com= © studocu Q MCQ in General pharmac... im Intravenous injections are more suitable for oily solutions: a) True b) False Biotransformation of the drugs is to render them: a. Less ionized b. More pharmacologically active ©. More lipid soluble 4. Less lipid soluble Metabolic transformation (phase 1) is: a) Acetylation and methylation of substances b) ‘Transformation of substances due to oxidation, reduction or hydrolysis ©) Glucuronide formation 4) Binding to plasma proteins Half life (¢ 4) is the time required to: 4) Change the amount of a drug in plasma by half during elimination 1b). Metabolize a half of an introduced drug into the active metabolite ©) Absorb a half of an introduced drug 4) Bind a half of an introduced drug to plasma proteins 2, Pharmacodynamics involves the study of following EXCEPT: 2) Biological and therapeutic effects of drugs 1) Absorption and distribution of drugs ©) Mechanisms of drug action 4) Drug interactions Pharmacodynamics involves the study of following? a) Mecha sof drug action b) Biotransformation of drugs in the organism. ©) Distribution of drugs in the organism oO 3 out of 13 ft ii a 4 Home University High School Books studocu.com= © studocu Q MCQ in General pharmac... © | 4) Exeretion of drug from the organism by What does *alfini a) A measure of how tightly a drug binds to plasma proteins ») ©) Ameasure of how intly a drug binds to a receptor d) A measure of inhibiting potency of a drug ©) Ameasure of bioavailability of a drug ‘Target proteins which a drug molecule binds are: a) Only receptors, b). Only ion channels ©) Only carriers d) All of the above An agonist is a substance that: 1) Interacts with the receptor without producing any effect b) Interacts w ith the receptor and initiates changes in cell function, producing various effects. ©) Increases concentration of another substance to produce effect d)_ Interacts with plasma proteins and doesn’t produce any effect An antagonist is a substance that: a) Binds to the receptors and initiates changes in cell function, producing maximal effect b)_ Binds to the receptors and initiates changes in cell function, producing submaximal effect ©) Interacts with plasma proteins and doesn’t produce any effect d)_ Binds to the receptors w hout directly alte ¢ their functions Idiosyncratic reaction of a drug is: a) A type of hypersensitivity reaction b) A type of drug antagonism ©) Unpredictable, inherent, qualitatively abnormal reaction to a drug ) Quantitatively exaggerated response oO 4 out of 13 ft ii Home University High School Books studocu.com= © studocu Q MCQ in General pharmac... © im ‘What phenomenon can occur in case of using a combination of drugs? a) Tolerance b) Tachyphylaxis ©) Accumulation d) Synergism Tachyphylaxis a) A drug interaction between two similar types of drugs b) Very rapidly developing tolerance ©) A decrease in responsiveness to a drug, taking days or weeks to develop 4d) None of the above Which effect may lead to toxic reactions when a drug is taken continuously or repeatedly? a) Refractoriness b) Cumulative effect ©) Tolerance ) Tachyphylaxis Which of the followin; NOT a pharmacokinetics process? a) Absorption b) Distribution ©) Metabolism d) Side effects Pharmacodynamics considers a) The way drups bri bout their therapeutic effects bh) The way drugs ate absorbed, distributed, metabolized, and excreted, ¢) The way drugs are derived from herbal and other natural sources. a) The way drugs can be used to diagnose, prevent andl treat illness The Liver is the major organ for oO 5 out of 13 ft ii a 4 Home University High School Books studocu.com= © studocu Q MCQ in General pharmac... im a) Fxeretion b) Metabolism ©) Absorption 4) Distribution Most drugs and metabolites are excreted by: a} ‘The kidneys by The Bile ©) The lungs 4) Perspiration, saliva and tears Which of the following routes of drug administration is most convenient and would not require skilled Health care supervision? a) PO (oral) b) 1V (intravenous) ©) IM (intramuscular) 4) SQ (subcutaneous) ‘The following are parenteral products EXCEPT a) Ampules bb Vials ©) Profilled syringes d) Topical Patenes ft ii a 4 Home University High School Books studocu.com= © studocu Q MCQ in General pharmac... im a) Trade name b) Chemical name ©) Generic name d) Proprietary Name The route of drug administration where Small amount of medication is injected just beneath epidermis a) Intradermal b) Intramuscular ©) Subcutaneous 4d) Intravenous "The component of a cell that aecepts and interacts with a drug molecue is ealled a) Ton channel b) Enzyme ©) Protein 4d) Receptor An antagonist is a drug that has; a) No affinity and intrinsic activity by. No affinity but has an intrinsic activity ©) Both affinity and intrinsic activity 4) Affinity but not intrinsic activit oO 7 out of 13 ft ii a 4 Home University High School Books studocu.com= © studocu Q MCQ in General pharmac... © im The term potency refers to the following EXCEPT; a) Drug’s highest strength at a very low concentration or dose b) A smaller dose may be needed to produce the same effect as another drug, ©) The higher the potency, the lower the dose needed to produce intense effect 4) The drug that will generate the maximum response at the highest dose ‘The length of time required for a drug to decrease concentration in the plasma by one-half. a) Half life b). Time maximum(Tmax) ©) Threshold time dy Peak time Each drug has a pregnancy classification attached to it. A drug labeled A means; a) Only given after risks to the fetus have been considered—animal studies show adverse reactions b) Defi fetal risks have be observed can Only given in life threatening situations ©) No adverse effects have been observed in animals—no human studies 4) No risk demonstrated to the fetus in any trimester Intrinsic activity is a drug's ability to elicit: a) Strong receptor binding b) Weak receptor binding ©) Response d) Excretion. Which of the following occurs on the extracellular domain(outside the cell) of the lipid bilayer and not the cytoplasmic domain, with regard to drug action? oO 8 out of 13 ft ii a 4 Home University High School Books studocu.com= © studocu Q MCQ in General pharmac... im b) Coupling with membrane associated molecules Tra «) Signaling 2) Which of the following drug targets involves inhibitors, false substrates, and a prodrug type? a) Receptors b) fom channels, 4) Carriers 3) What is the correct order of bond strength, from strongest to weakest? a) Vander b) lonic > Covalent > Hydrogen > > Hydrogen > Ionic > Covalent Van der Waals 4) Covalent > Ionic > Hydrogen > Van der Waals €) Vander Waals > Hydrogen > Covalent > Ionic 4) Which of the following concentration of free drug is at half-maximal bind a) ECS0 b) Emax ) Kd d) Bmax ©) LDSO 5) Clinical effectiveness of a drug depends on its potency. a) True Intrinsic activity is a drug's ability to elicit: 4) Strong receptor binding bb) Weak receptor binding 4) Exeretion oO 9 out of 13 ft ii a 4 Home University High School Books studocu.com= © studocu MCQ in General pharmac... © im ¢) Distribution Which direction would a partial agonist shift the dose-response curve when compared to a full agonist? a) To the left b) To the right ©) Down ) Up ¢) To the right and possibly down Which direction would a competitive antagonist (plus agonist) shift the doseresponse curve when compared to a full agonist? a) To the left b) To the right ©) Down ) Up «) To the right and possibly down Which direction would a non-competitive antagonist (plus agonist) shift the dose response curve when compared to a full agonist? a) To the left b) To the right ©) Down ) Up ) Down and possibly to the right A competitive antagonist affects the agonist___ and a non-competitive antagonist affect the agonist. b) Efficacy; Potency ) Duration; Speed 4) Speed; Duration For most drugs, a frequeney di ibution of the response plotted against the log of the dose (quantal) produces what kind of curve? a) Linear b) Exponential ©) Logarithmic oO 10 out of 13 ft ii a Home University High School studocu.com Books= © studocu Q MCQ in General pharmac... im 4) Gaussian (normal) distribution Generally, which of the following is the correct order as dos is increased? a) DSO < LDS0 < TDs0 ¢) LDSO < TDS0 < EDSO d) LDS0 < EDS0 < TDSO ¢) TDS0 < LDS0 < EDSO 13) Which of the following is the median effective dose, or the dose at which 50% of the Individuals exhibit the specified quantal response? a) LD50 ©) ECSO 4) TDSO et. Which of the following is considered the therapeutic index (or ratio)? DSO / EDSO D50/EDSO EDSO/ TDSO EDSO / LDSO ich of the following can be used as a relative indicator of the margin of safety of adrug? a) LDSO b) EDSO ©) EC50 @) TDS Which of the following is the most relevant use of therapeutic index? b)Mi Home University High School Books studocu.com= © studocu MCQ in General pharmac... © im Which of the following is the most relevant use of therapeutic index? +b) Multiple measures of effectiveness are possible (e.g. aspirin) ©) Measure of impunity with which an overdose may be tolerated 4) Toxicities may be idiosyncratic (e.g. propranolol in asthmatics) Which of the following refers to an increased intensity of response to a drug? a) Idiosyncratic b) Hyporeactive 4d) Hypersensitive ¢) Tolerance 18) Concerning drug receptor interactions, the constant Kd refers to: a) Maximum physiological effect b) Mi i €) the drug en d) all of the above 19) Example(s) of second messenger effect(s): A) Increases in cAMP intracellular concentration B) Changes in intracellular caleium concentration C) Phosphoinositide effects oO 12 out of 13 ft ii a Home University High School studocu.com Books= © studocu MCQ in General pharmac... 20) ECS0 mainly refleets a drug's: A) Maximal effect C) lethality D) ease of elimination B) safety 21) Drug effects are thought to he proportional to the number of occupied receptors B) false 22) Receptors are usually: a) lipids by pre c) DNA d) RNA 23) Longer-lasting physiological response to dru: Ajlncrease —in.—heart,~—rate-— following —— epinephrine —_infusion 24) True statement(s) concerning competitive inhibition: B) with competitive inhibition, the do: ts curve the shifled to the left C) with competitive inhibition, maximal drug effect cannot be obtained, even at high agonist cong oO 13 out of 13 > Ep Home University High School Books= © studocu Q MCQ in General pharmac... © im 23) Longer-lasting physiological response to drug: Ajincrease in heart’ ~—rate_—following — epinephrine —_ infusion. 24) True statement(s) concerning competitive inhibition: B) with competitive inhibition, the dose-effects curve the shifled to the left C) with competitive inhibition, maximal drug effect cannot be obtained, even at high agonist concentrations D)all the above 25) An example of a receptor which is a structural protein, A) Na/K ATPase B) acetylcholinesterase. D) DNA F) phospholipase C 26) Factors that may cause variation in drug responsiveness: A) Changes in the number or function of receptors B) Tachyphylaxis, ©) idiosyncratic drug responses D) hypersensitivity reactions oO 13 out of 13 ft ii a 4 Home University High School Books studocu.com