Proton Pump

Inhibitors (PPIs)
M. Hassan Bilal (M.Phil. Pharmacology)
Contents
Introduction
Clinically Used PPIs
Related Terms
Mechanism of Action of Proton-Pump
Pharmacokinetics of PPIs
Therapeutic uses
References

PPIs 2
Introduction

Proton-pump inhibitors (PPIs) represent a class of drugs most prominently

known for their use in acid-related disorders.

They are the most potent suppressors of gastric acid secretion and can
diminish daily production of acid by 80-90 percent. 

PPIs are the prodrugs that get activated in acidic environment.

PPIs 3
PRESENTATION TITLE 4
Introduction cont....

The proton pump inhibitor, omeprazole as pro-­‐drug is converted to its active

form in acidic medium. As weak base it specially concentrates in the parietal
cell, where it is activated by a proton-­‐catalyzed process to generate a
sulfenamide intermediate. The sulfenamide interacts covalently with
sulphydryl groups of cysteine residues in the extracellular domain of the
proton pump (H + K + -­‐ATPase) there by inhibiting its activity

PPIs 5
Clinically Used
PPIs
(Proton Pump Inhibitors)
Clinically Used PPIs

o Omeprazole (RISEK, PRILOSEC and others)

o Esomeprazole (NEXIUM)

o Lansoprazole (PREVACID)

o Dexlansoprazole (KAPIDEX)

o Pentoprazole (PROTONIX)

o Rabeprazole (ACIPHEX)

PPIs 7
Related Terms
Parietal cells & Proton pump
 Parietal Cell

•"Parietal cells are the epithelial cells which are located in gastric glands found in the
lining of the fundus and in the body of the stomach. They secrete hydrochloric
acid and intrinsic factor"
•

PPIs 9
 Proton Pump

A proton pump is an integral membrane protein pump that builds up a proton gradient across
a biological membrane. Proton pumps catalyze the following reaction:

H+ [on one side of a biological membrane] + energy ⇌ H+ [on the other side of the membrane]

PPIs 10
Mechanism of
Action of PPIs
(Proton Pump Inhibitors)
 Mechanism of Action of PPIs

The activated drug molecules bind covalently to the sulfhydryl group of cysteines (amino acids) present
on H/K-ATPase Pump. It inactivates pump irreversibly. Acid secretion is resumed when new pumps are
synthesized and inserted into membrane.

PPIs 12
Pharmacokinetics
of PPIs
(Proton Pump Inhibitors)
Parietal Cell

PRESENTATION TITLE 14
Areas of growth

PRESENTATION TITLE 15
“ ”
Richa
rd
Brans
on

Business opportunities are like

buses. There's always another one
coming.

PRESENTATION TITLE 16
Meet our team
Takuma Hayashi Mirjam Nilsson
President Chief Executive Officer

Flora Berggren Rajesh Santoshi

Chief Operation Officer VP Marketing

PRESENTATION TITLE 17
The full team

Takuma Hayashi Mirjam Nilsson Flora Berggren Rajesh Santoshi

President Chief Executive Officer Chief Operations Manager VP Marketing

Graham Barnes Rowan Murphy Elizabeth Moore Robin Kline

VP Product SEO Strategist Product Designer Content Developer

PRESENTATION TITLE 18
Plan for product launch 

1 2 3 4 5
Planning Marketing Design Strategy Launch
Synergize scalable Disseminate Coordinate Foster holistically Deploy strategic
e-commerce standardized metrics e-business applications superior networks with
methodologies compelling e-
business needs

PRESENTATION TITLE 19
Timeline
Sep 20XX Jan 20XX May 20XX
Synergize scalable Coordinate e-business Deploy strategic networks with
e-commerce applications compelling e-business needs

Foster holistically superior

Disseminate standardized metrics methodologies

Nov 20XX March 20XX

PRESENTATION TITLE 20
Areas of focus
B2B market scenarios Cloud-based opportunities
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of the competition Establish a management framework from
Capitalize on low-hanging fruit to identify the inside
a ballpark value
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PRESENTATION TITLE 21
How we get there
ROI
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PRESENTATION TITLE 22
Summary

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PRESENTATION TITLE 23
Thank you
Mirjam Nilsson​
mirjam@contoso.com
www.contoso.com