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Manifestations of and Risk Factors For Aminoglycoside Nephrotoxicity - UpToDate
Manifestations of and Risk Factors For Aminoglycoside Nephrotoxicity - UpToDate
All topics are updated as new evidence becomes available and our peer review process is complete.
INTRODUCTION
Acute kidney injury is a relatively common complication of therapy with the aminoglycoside
antibiotics, with a rise in the plasma creatinine concentration of more than 0.5 to 1 mg/dL (44
to 88 micromol/L) or 50 percent increase in plasma creatinine concentration from baseline
occurring in 10 to 20 percent of patients [1-4]. In children, aminoglycoside-induced acute
kidney injury can be seen in as many as 20 to 33 percent of treated children [5].
Aminoglycosides are freely filtered across the glomerulus and then partially taken up by,
concentrated in, and produce damage to proximal tubular cells. The kidney injury induced by
these drugs is related to their preferential accumulation in the kidney cortex. After
administration, up to 5 to 10 percent of the parenteral dose is retained in the kidney cortex,
where it can achieve concentrations greatly exceeding the concurrent serum concentration
[6]. This preferential sequestration of aminoglycosides in proximal tubule cells accounts for
the observation that kidney failure may become clinically apparent as late as several days
after the drug has been discontinued. (See "Pathogenesis and prevention of aminoglycoside
nephrotoxicity and ototoxicity".)
The manifestations of and risk factors for aminoglycoside nephrotoxicity are reviewed here.
Acute tubular necrosis due to ischemia or other insults and the pathogenesis and potential
therapy of aminoglycoside nephrotoxicity are discussed separately:
● (See "Etiology and diagnosis of prerenal disease and acute tubular necrosis in acute
kidney injury in adults".)
MANIFESTATIONS
The acute tubular necrosis that occurs from aminoglycoside exposure is unlikely to be severe,
with incremental increases in the plasma creatinine that are usually mild (0.5 to 2.0 mg/dL [44
to 177 micromol/liter]) [7]. However, aminoglycosides can result in toxicity, mandating kidney
replacement therapy in patients who already have chronic kidney disease (CKD). The urine
sediment most commonly shows mild proteinuria, hyaline, and granular casts. The fractional
excretion of sodium is generally above 1 percent (calculator 1) or, for standard units,
(calculator 2). (See "Fractional excretion of sodium, urea, and other molecules in acute kidney
injury".)
Course — Given that proximal tubules can regenerate, the usual course of aminoglycoside
nephrotoxicity is one of recovery of kidney function. The plasma creatinine concentration
usually returns to the prior baseline level within 21 days after cessation of therapy. However,
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resolution of the acute episode may be delayed if the patient remains hypovolemic, septic, or
catabolic; in these settings, tubular regeneration cannot occur.
Studies in other forms of reversible acute kidney injury suggest that normalization of the
plasma creatinine concentration and even the glomerular filtration rate may not reflect
complete recovery. Irreversible nephron loss in this setting may be masked by compensatory
hyperfiltration in the remaining normal glomeruli. (See "Kidney and patient outcomes after
acute kidney injury in adults".)
Although a pattern of a nonoliguric acute kidney injury five to seven days after
aminoglycoside exposure is suggestive, differentiating aminoglycoside-induced acute kidney
injury from other etiologies of acute tubular necrosis can be difficult given that it often occurs
in the setting of significant comorbid conditions, sepsis, and concomitant nephrotoxin
exposure. In addition, acute kidney injury is frequently multifactorial, and aminoglycoside
nephrotoxicity is only one of its components. An essential initial diagnostic step in the
diagnosis of aminoglycoside nephrotoxicity is a careful history with attention to potentially
reversible etiologies, such as reduced effective arterial volume or urinary tract obstruction. In
addition, a review of all imaging procedures for intravenous contrast exposure and
medications for concomitant nephrotoxin use is imperative.
RISK FACTORS
Several risk factors have been identified that increase the risk of aminoglycoside
nephrotoxicity [1-3]. The major risk factors are:
For any given aminoglycoside, a direct relationship exists between serum concentrations of
aminoglycosides, renal cortical proximal tubule cell concentrations, and nephrotoxicity
[1,10,11]. Owing to the renal cortical sequestration of aminoglycosides, the risk of
aminoglycoside-induced nephrotoxicity is also increased in patients given the drug in
repeated courses separated by a few days or weeks [1]. In contrast, renal cortical
accumulation is less when aminoglycosides are given as one large, daily dose, as in once-daily
dosing programs, because of the saturable nature of the renal cortical uptake [12]. (See
"Dosing and administration of parenteral aminoglycosides", section on 'Nephrotoxicity'.)
Advanced age — Advanced age has long been held to be an important risk factor in the
development of aminoglycoside nephrotoxicity [13-17]. This increased risk is postulated to be
secondary to the impaired capacity for cellular repair and regeneration found in this patient
population. In addition, advanced age may result in excessive dosing of aminoglycosides from
an overestimation of creatinine clearance [17].
Overall, patients with CKD are at increased risk for aminoglycoside nephrotoxicity because the
risk of inadvertent overdosing is greater than in patients with normal kidney function. This
increased risk is due to the imprecision of our bedside tools in estimating kidney function and
aminoglycoside dosing. Furthermore, patients with CKD have less kidney functional reserve
and an attenuated ability to recover from aminoglycoside nephrotoxicity.
[20,21]. This can occur in the clinical setting of intravascular volume depletion, heart failure,
sepsis, and advanced liver disease. Moreover, kidney ischemia appears to accelerate the time
course for aminoglycoside nephrotoxicity.
Two factors have been postulated to mediate this synergism between the aminoglycoside and
kidney ischemia:
● The aminoglycoside interferes with cell energetics, thereby increasing the susceptibility
to kidney injury during an ischemic episode [22]. This synergism is most prominent in
the S3 segment of the proximal tubule; this segment is particularly sensitive to ischemic
injury secondary to minimal reperfusion resulting in continuing hypoxia to the area.
Sepsis — In addition to volume depletion, as described above, endotoxin also enhances the
nephrotoxicity of the aminoglycosides [24]. Although decreased kidney perfusion due to renal
vasoconstriction may play a contributory role, endotoxin also appears to be associated with
enhanced drug accumulation in the tubules. How this occurs is not known. (See
"Pathogenesis and etiology of ischemic acute tubular necrosis".)
In comparison, there seemed to be no increase in toxic effects when all treated patients are
included, which more closely simulates the real world [2]. Furthermore, it is unclear if the
initial results with cephalothin can be extrapolated to any of the other cephalosporin-type
drugs. Evidence suggests that this probably does not occur and that the cephalosporins can
be safely given in conjunction with an aminoglycoside [3].
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Although it seems likely that cephalosporins do not have a major effect on aminoglycoside
nephrotoxicity, there is suggestive evidence that concurrent administration of a penicillin may
actually be protective [26,27]. How this occurs is not known, but decreased tubular uptake of
the aminoglycoside may be involved. It must be emphasized, however, that penicillins,
particularly carbenicillin, piperacillin, and ticarcillin, can physically complex with the
aminoglycosides; as a result, these agents cannot be mixed in the same intravenous infusion.
Remarkably, whether an elevated trough or peak level contributes to the increased risk of
nephrotoxicity with aminoglycosides is not fully elucidated. In one analysis, no causal
relationship could be found between a serum peak or trough aminoglycoside level in several
reviewed studies [30].
The therapeutic success observed with once-daily aminoglycoside programs with their
associated supratherapeutic levels certainly casts doubt on whether a peak aminoglycoside
level increases nephrotoxic risk in this clinical setting. However, an elevated trough level has
been shown to increase the nephrotoxic risk in once-daily aminoglycoside programs in older
adults [14]. Similarly, in another older patient cohort, an elevated peak level increased
aminoglycoside nephrotoxicity with conventional dosing [14].
Although there remains uncertainty about whether peak or trough levels are primarily
responsible for nephrotoxicity, serum monitoring of aminoglycosides is beneficial and
recommended due to the following reasons:
● The limitations of our bedside estimates of glomerular filtration rates on which we base
our aminoglycoside dosing are often imprecise.
● Monitoring programs ensure that less toxic antibiotics will be selected in patients with
contraindications to aminoglycosides.
● These programs also ensure that appropriate therapeutic doses of antibiotics are given
earlier in a patient's therapy.
glomerular filtration rate allowing for appropriate modeling of the pharmacokinetics. Among
the benefits cited were fewer instances of nephrotoxicity and treatment failure and shorter
hospital stays [31-34].
Serum peak and trough levels should be measured periodically when conventional
aminoglycoside dosing is used. Moreover, peak and trough monitoring in conventional dosing
is imperative in older patients with obesity. By contrast, once-daily aminoglycoside programs
only require a periodic trough level. This trough level is used to determine the timing of the
next dose of aminoglycoside. (See "Dosing and administration of parenteral
aminoglycosides".)
Type of aminoglycoside — Not all of the aminoglycosides appear to have the same potential
for nephrotoxicity. However, comparing the relative risk of each of the aminoglycosides for
nephrotoxicity is problematic due to the variability in the clinical studies regarding the
incidence of nephrotoxicity, the use of controls, and the criteria used to define nephrotoxicity.
Overall, when prospective comparative trials are compared, gentamicin has the greatest
nephrotoxic potential, followed in decreasing order of nephrotoxicity by tobramycin,
amikacin, and netilmicin [1,28,35]. Although amikacin and netilmicin are considered less
nephrotoxic than gentamicin and tobramycin, the difference is not considered profound [1].
Few data are available to determine the nephrotoxicity of plazomicin [36,37]. The relative
nephrotoxic risk of a specific aminoglycoside will always depend on patient factors, comorbid
disease, and the clinical setting in which the aminoglycoside is used.
Frequency of dosing — The frequency of dosing may also be a risk factor for the
development of aminoglycoside nephrotoxicity. This is supported by the favorable clinical
data observed with the once-daily aminoglycoside dosing programs. In once-daily
aminoglycoside therapy, a much larger loading dose is given every 24 to 48 hours. The
rationale for this approach is to exploit the concentration-dependent bactericidal activity and
postantibiotic effect of aminoglycosides. This approach to aminoglycoside dosing has
demonstrated improved clinical efficacy and reduced nephrotoxicity relative to conventional
aminoglycoside dosing [20,21]. This is discussed in detail separately. (See "Dosing and
administration of parenteral aminoglycosides", section on 'Comparing extended-interval and
traditional intermittent dosing'.)
SUMMARY
● Acute kidney injury from aminoglycoside exposure typically manifests after five to seven
days of therapy. The nonoliguric aspect of the kidney failure is secondary to a loss in
renal concentrating ability believed to be the result of distal tubular damage. The acute
tubular necrosis that occurs from aminoglycoside exposure is rarely severe. (See
'Nonoliguric acute kidney injury' above.)
● Given that proximal tubules can regenerate, the usual course of aminoglycoside
nephrotoxicity is one of recovery of kidney function. The plasma creatinine
concentration usually returns to the prior baseline level within 21 days after cessation of
therapy. However, resolution of the acute episode may be delayed and incomplete. (See
'Course' above.)
● Several risk factors have been identified that increase the risk of aminoglycoside
nephrotoxicity. The major risk factors are prolonged duration of therapy, advanced age,
comorbid disease, reduced effective arterial volume, sepsis, concomitant medications,
elevated plasma drug concentrations, type of aminoglycoside, and frequency of dosing.
(See 'Risk factors' above.)
ACKNOWLEDGMENT
The UpToDate editorial staff acknowledges Brian S Decker, MD, PharmD (deceased), who
contributed to an earlier version of this topic review.