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  • Sas 9

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    This document lists various crude drugs from marine sources and their composition and effects. It categorizes the drugs into groups for their antiviral, antiparasitic, anticancer, antispasmodic, and cardiovascular effects. Some of the drugs listed and their source organisms include: Ara-A from Tethya crypta which has antiviral effects; Fucoidan from brown algae with HIV and herpes inhibiting effects; Bryostatine I from Burgula nertina as the first natural product containing guanine and sulfone units; and Eledoisin from Eledone moschata which is a potent heart stimulant over 5000x more active than cardiac glycosides.

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    SAS-9

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    This document lists various crude drugs from marine sources and their composition and effects. It categorizes the drugs into groups for their antiviral, antiparasitic, anticancer, antispasmodic, and cardiovascular effects. Some of the drugs listed and their source organisms include: Ara-A from Tethya crypta which has antiviral effects; Fucoidan from brown algae with HIV and herpes inhibiting effects; Bryostatine I from Burgula nertina as the first natural product containing guanine and sulfone units; and Eledoisin from Eledone moschata which is a potent heart stimulant over 5000x more active than cardiac glycosides.

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    2 views2 pages

    Sas 9

    Uploaded by

    jenet soleil
    This document lists various crude drugs from marine sources and their composition and effects. It categorizes the drugs into groups for their antiviral, antiparasitic, anticancer, antispasmodic, and cardiovascular effects. Some of the drugs listed and their source organisms include: Ara-A from Tethya crypta which has antiviral effects; Fucoidan from brown algae with HIV and herpes inhibiting effects; Bryostatine I from Burgula nertina as the first natural product containing guanine and sulfone units; and Eledoisin from Eledone moschata which is a potent heart stimulant over 5000x more active than cardiac glycosides.

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    Class Crude Drug Scientific Name Composition And Effect Other info

    Ara-A Tethya crypta ➢ Arabinosyl nucleoside


    ➢ Classified into four groups:
    1. Pyrrolyl-substituted
    2. Pyrrolinyl-substituted
    Euditomins Eudistoma olivaceum ➢ Beta-carboline derivative
    Antiviral Agents

    3. Unsubstituted
    4. Tetrahydro-beta-carboline derivatives
    with a 1,3,7-oxathiazepine ring
    Didemnins Trididemnum spp. ➢ Didemnin B Has potential antitumor Effect
    ➢ Anti-HIV activity
    Avarol and Avarones Disidea avara
    ➢ Treatment of AIDS
    Patellazole B Lissoclinum patella ➢ Potent activity against Herpes Simplex Virus
    Laminaria
    Fucoidan ➢ Sulphated polysaccharide compound ➢ HIV and Herpes
    (Brown algae)
    ➢ Broad spectrum antihelmithic(Roundworms,
    Digenia simplex
    Alpha-kainic acid tapeworms, whipworms)
    (Red algae)
    Antiparasitic Agent

    ➢ Treatment in ascariasis
    Chondria armata
    Domoic acid ➢ Prominent antihelminthic activities
    Alsidum corallinum
    ➢ Hypotensive
    Laminine Laminariales ➢ Methylated lysine derivative
    ➢ Smooth muscle relaxant
    Bengamide F ➢ From marine sponge
    ➢ From Sea cucumber
    Cucumechinoside F ➢ Complex tetracyclic Triterpenic glycoside
    ➢ Antiprotozoal
    ➢ Cytosar
    Ara-C ➢ Treatment for acute myelogenous lukemia
    Anticancer Agents

    (Cytosine Cryptotethya crypta and human acute lukemia


    Arabinoside) ➢ Potent tumor inhibitor in cases of sarcoma-
    180, Erlich carcinoma and L-1210 lukemia
    Ara-A
    ➢ Spongosine
    (Adenine ➢ Hepes encephalitis
    ➢ Spongourdine
    Arabinoside)
    ➢ Antineoplastic activity at an extremly low
    Bryostatine I Burgula nertina
    dose
    Agelas spp
    Antispasmodic ➢ The first natural product containing guanine
    (Okinawa sea
    Agents and sulfone units
    sponge)
    ➢ From sea anemone
    ➢ Steroidal compounds
    Antopleura xanthogrammica ➢ Potent heart stimulant that has 5000x more
    Cardiovascular Agents
    ➢ Polypeptide of 49 amino acids
    activity that cardiac glycosides
    ➢ Hypotensive and vasodilatory
    Eledoisin Eledone moschata ➢ 50x more potent than Ach, H2, or bradykinin
    in provoking hypotension
    Octopus vulgaris
    ➢ Cardiotonic activity
    O. Macropus
    Octopamine ➢ Tetramine – toxic compound from Neptunea
    Eledone muschata
    antiqua
    Laminaria angustata

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