In: Veterinary Toxicology, V. Beasley (Ed.

)
Publisher: International Veterinary Information Service (www.ivis.org), Ithaca, New York, USA.

Incomplete List of Teratogens Used in Clinical Medicine (9-Aug-1999)

V. Beasley
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Incomplete List of Teratogens Used in Clinical Medicine

Chemical Dosage

Acetazolamide 0.6% (in diet)

ACTH 5 mg q 6 h/3 days

Actinomycin D 25 - 100 mcg/kg

Alcohol 1.0 - 210 gm/kg

Aldosterone 0.05 mg/day

Amantadine HCl 10 mg/kg

Aminophylline 100 - 200 mg/kg

Aminopterin 0.1 mg/kg

Anesthetics -

Antibodies -

Apomorphine 0.025 mg/embryo (chick)

Barbituric Acid 0.16% (mice) (in diet)

Busulfan 18 - 34 mg/kg

Caffeine 75 - 150 mg/kg

Chlorambucil 8 - 12 mg/kg

Chloramphenicol 100 - 200 mg/kg

Chlortetracycline 10 mg/kg

Colchicine 1 - 2 mg/kg (monkey)

Cortisone -

Coumarin Derivatives 4 mg/kg (mice)

Dextroamphetamine Sulfate 1 mg/kg

Diazepam 200 mg/kg

Diethylstilbestrol 10 - 42 mg

Dimethyl Sulfoxide 4.0 ml/kg

Diphenylhydantoin 75 - 150 mg/kg (mice)

 Incomplete List of Teratogens Used in Clinical Medicine (continued)

Chemical Dosage

Disulfiram 100 mg (in diet)

L-Dopa 10 mg/kg

Epinephrine 1 - 50 mcg

Fluorouracil 12 - 37 mg/kg

Griseofulvin 50 - 500 mg/kg

Hypervitaminosis A 35,000 I.U.

Imipramine 15 mg/kg

Isoniazid -

Lithium 212 mg/kg hen 85 mg/kg

Marihuana 4.2 mg/kg

Meclizine 20 - 80 mg/kg

Methaqualone 0.8% (in diet)

Methotrexate 10 mg/kg (mice)

Nitrous oxide 50% (by inhalation)

Noradrenalin 25 mcg/embryo

Phenobarbital 0.16% (mice) (in diet)

Physostigmine 0.05 - 15.0 mg/embryo (chick)

Pilocarpine 3 - 12 mg/embryo (chick)

Prednisolone 2.5 mg/kg

Prochlorperazine 2.5 - 10 mg/day

Reserpine 1.5 mg/kg

Salicylate 300 mg/kg

Sulphonamides 50 mg/kg

Tetracycline 40 - 80 mg/kg

Tolbutamide 300 mg/day

Rat data unless otherwise noted. From Shepard (1976)

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