NU 102 2021 / 2022

Drug Research Form

Student Name:________________________________ Date:__________________

Generic Name Amikacin Sulphate

Trade Name NKacin tm

Class Anti-infective.

Action Inhibits protein synthesis in bacteria at level of 30S

ribosome

Indication/s Treatment of serious gram-negative bacterial infections

and infections caused by staphylococci when penicillin
or other less toxic drugs are contraindicated

Contraindication/s Hypersensitivity to aminoglycosides; Most parenteral

products contain bisulfites and should be avoided in
patients with known intolerance; Pedi: Products
containing benzyl alcohol should be avoided in
neonates; Intestinal obstruction

Side effect/s Ataxia, ototoxicity, nephrotoxicity,

diarrhea, nausea, vomiting

Common interaction/s with other
medication/s
Inactivated by penicillin and cephalosporin when co-
administered to patients with renal insufficiency.
Possible respiratory paralysis after inhalation
anesthetics or neuromuscular blocking agents. Increase
Incidence of ototoxicity with loop diuretics. Increase
incidence of nephrotoxicity with other nephrotoxic
drugs. Neomycin may increase anticoagulant effects of
warfarin.

Route/s of administration with IM, IV (Adults and Children): 5 mg/kg q 8 hr.

dosage

Therapeutic level IM: rapid / 30–90 min / 6–24 hr.

IV: rapid / 15–30 min / 6–24 hr.

Method/s of preparation and

 NU 102 2021 / 2022
Drug Research Form

Student Name:________________________________ Date:__________________

administration Keep patient well hydrated (1500–2000 mL/day)

during therapy.
IM administration should be deep into a well-developed
muscle. Alternate injection sites.
: If aminoglycosides and penicillin or cephalosporin
must be administered concurrently, administer in
separate sites.

Nursing consideration/s / Renal impairment(dose adjustments necessary; blood

precaution/s level monitoring useful in preventing ototoxicity and
nephrotoxicity); Hearing impairment; Neuromuscular
diseases such as myasthenia gravis; Obese patients

Patient / Family teaching

Instruct patient to report signs of hypersensitivity,
tinnitus, vertigo, hearing loss, rash, dizziness, or
difficulty urinating.
Advise patient of the importance of drinking plenty of
liquids.
Teach patients with a history of rheumatic heart disease
or valve replacement the importance of using
antimicrobial prophylaxis before invasive medical or
dental procedures.
Advise female patient to notify health care professional
if pregnancy is planned or suspected or if breast
feeding.

Reference (Use APA Guidelines) Deglin, J, Vallerand, A, Sanoki,C. (2015) Davis

Drug Guide for nurses (14th ed). USA: F. A Davis
Company. page 134.

______________________________________
Generic Name

Trade Name

Class

Action

Indication/s
 NU 102 2021 / 2022
Drug Research Form

Student Name:________________________________ Date:__________________

Contraindication/s

Side effect/s

Common interaction/s with other

medication/s

Route/s of administration with

dosage

Therapeutic level

Method/s of preparation and

administration

Nursing consideration/s /
precaution/s

Patient / Family teaching

Reference (Use APA Guidelines)