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Cerebrospinal Fluid & Blood Brain Barrier: DR Mohd Imran
Cerebrospinal Fluid & Blood Brain Barrier: DR Mohd Imran
&
Blood Brain Barrier
Dr Mohd Imran
Assistant Professor
Department of Anatomy
JNMC, AMU
CSF - Cerebrospinal Fluid
• Cerebrospinal fluid is somewhat similar to that
of blood plasma and interstitial fluid
CSF formed-
per day is about 500 ml (Guyton)
0.35-0.40 ml/min (GRAY’S Anatomy)
550 ml/day (Ganong)
Circulation and Absorption
• CSF is produced mainly in the lateral ventricles,
from where it passes through interventricular
foramina (of Monro) into the 3rd ventricle, and
then via cerebral aqueduct into the 4th ventricle
2. Shock absorber
Answer-
• CNS infections are usually fatal because
there are no antibodies in the CSF
Answer-
• Normally the brain floats freely in CSF but
when CSF is removed, the brain sags and
hangs on vessels and cranial nerve roots
Answer-
• When the internal jugular veins are compressed
in the neck, there is rise in cerebral venous
pressure which inhibits the absorption of CSF
into the dural venous sinuses.
• Consequently there occurs a prompt rise in
manometric reading of the CSF pressure.
Answer-
• Abnormal increase in the volume of
cerebrospinal fluid (CSF) within the
skull
Q. Enumerate the openings through
which cavities within the brain
communicate with the subarachnoid
space around the brain
Answer-
• Foramen of Magendie (median aperture)
Answer-
• Internal hydrocephalus: Excessive
accumulation of CSF within the ventricular
system of brain
a) Interpeduncular cistern
b) Cisterna ambiens
c) Pontine cistern
d) Cerebellomedullary cistern
3. Regarding cavities of brain, all of the
following statements are correct
except:
• causes a breakdown of
the blood-brain barrier
• Chloramphenicol • Phenylbutazone
• Tetracyclines
• Sulphonamides • Neuro-transmitters
• Thiopental (lipid like exogenous
soluble) – Epinephrine
– Dopamine
• Atropine (lipid
soluble)
PARKINSON'S DISEASE
– there is deficiency of neurotransmitter
dopamine in the corpus striatum
1 – a
2 – d
3 – c
• Thank you