Pharmacologic

The goal of treatment during an acute gout attack is suppression of inflammation and control of
pain.
 Nonsteroidal anti-inflammatory drugs (NSAIDs) PO
o Ibuprofen 800 mg three to four times daily or Indomethacin 25 to 50 mg four
times daily; 5 to 10 days or until symptoms resolve
 Colchicine PO
o 30 to 35 mg prednisolone PO for 5 days
 Corticosteroids PO
o Low-dose therapy: 2 × 0.5 mg initially, then single administration 0.5 mg after 1
hour
Chronic gout treatment should aim to prevent gout progression and further gout flares, to
eliminate any urate deposits, and to reverse tophus formation.
 Xanthine oxidase inhibitor: Allopurinol
o Initially 50 to 100 mg/day; increase to max. 800 mg/day
 Xanthine oxidase inhibitor: Febuxostat
o Initially 80 mg/day, increase to 120 mg/day if necessary
 Uricosuric agent: Probenecid
o Probenecid can be combined with allopurinol if allopurinol alone is insufficiently
effective
Engel, B., Just, J., Bleckwenn, M., & Weckbecker, K. (2017). Treatment Options for
Gout. Deutsches Arzteblatt international, 114(13), 215–222.
https://doi.org/10.3238/arztebl.2017.0215

Non-Pharmacologic
 Choose healthier beverages
 Avoid foods high in purines
 Exercise regularly and lose weight
 Vitamin C intake above 500 mg/day

Líška D. (2021). Non-pharmacological treatment of gout. Nefarmakologická liečba dny. Vnitrni

lekarstvi, 67(E-2), 25–28.