This document provides information about aspirin, including its generic and chemical names, classification, mechanism of action, uses, and evaluation parameters. It describes assays to quantify the amount of aspirin in tablets, including titrating samples with sodium hydroxide and hydrochloric acid. Finally, it briefly mentions the multi-step process of drug development required to bring a new pharmaceutical like aspirin to market.
This document provides information about aspirin, including its generic and chemical names, classification, mechanism of action, uses, and evaluation parameters. It describes assays to quantify the amount of aspirin in tablets, including titrating samples with sodium hydroxide and hydrochloric acid. Finally, it briefly mentions the multi-step process of drug development required to bring a new pharmaceutical like aspirin to market.
This document provides information about aspirin, including its generic and chemical names, classification, mechanism of action, uses, and evaluation parameters. It describes assays to quantify the amount of aspirin in tablets, including titrating samples with sodium hydroxide and hydrochloric acid. Finally, it briefly mentions the multi-step process of drug development required to bring a new pharmaceutical like aspirin to market.
This document provides information about aspirin, including its generic and chemical names, classification, mechanism of action, uses, and evaluation parameters. It describes assays to quantify the amount of aspirin in tablets, including titrating samples with sodium hydroxide and hydrochloric acid. Finally, it briefly mentions the multi-step process of drug development required to bring a new pharmaceutical like aspirin to market.
B.PHARMA 4th year R.I.T.M LUCKNOW ROLL NO:1820350065 SUBMITTED TO: MISS YASMIN KHATOON TABLE OF CONTENT
• General introduction of aspirin
• Evaluation of aspirin tablet • Assay of aspirin • Method of development of aspirin • References GENERAL INTRODUCTION OF ASPIRIN • GENERIC NAME: Acetylsalicylic acid • Classified in british formulary as NON STEROIDL ANTIINFLAMATORY DRUGS. • CHEMICAL FORMULA: C9H8O4 • Average molecular weight: 180.15 • SYNONYMS: Acidum acetylsalicylicum, Apirina. • MOA: Inhibitis prostaglandins synthesis, by inhibiting COX-1 AND COX-2 enzymes. • IUPAC NAME: 2-(acetyloxy)benzoic acid GENERAL INTRODUCTION OF ASPIRIN • MELTING POINT: 1350C • USES: • Anti inflammatory • Anti platelets • Fever • Cardio vascular disease • Myocardial infraction • Transient ischemic attacks (TIA) EVALUATION PARAMETER OF ASPIRIN • Drug evaluation may be defined as determination of identiy, quality of drug. • WEIGHT VARIATION: MEAN= 175.7mg • FRIABILITY: 1) 2.7unit weight 2) 1.85 unit weight 3) 2.7 unit weight • HARDBNESS:3.5+3.6+3.6+3.8+8+3.9= 3.066 N • DISINTEGRATION ( DT TIME) 10+9+10=29/3=9.6 min • DISSOLUTION: PASSED ASSAY OF ASPIRIN
• 15g of Acetyl salicylic acid dissolve in 15ml of ethanol.
• Add 50ml of 0.5 M NaOH. • Boil for 10 minute and then cool. • Titrate excess of alkali qwith 0.5M HCL using phenol red solution as indicator • Difference between titration represents amount of NaOH required. ASSAY OF ASPIRIN GASTRO-RESISTANT TABLETS
• 20 Tablets weighed and powdered.
• powder containing 0.5g of aspirin weighed nd powdered. • 30ml og 0.5M NaOH is added and boiled upto 10 minute. • Allowded foe cooling and titrated with 0.5M HCL by adding phenol red indicator. METHOD OF DEVELOPMENT OF ASPIRIN
• Drug development is the
process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. REFERENCES • https://en.wikipedia.org/wiki/Drug_development • https://pubchem.ncbi.nlm.nih.gov/compound/Aspirin • Leon Lachman book of industrail pharmacy.