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A new generation of rare-earth-based quantum dots vs. their commercial

counterparts for applications in biology and medicine. The influence of
shape and size on intestinal uptake a...

Conference Paper · February 2014

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6 authors, including:

Jarosław Kaszewski Anna Słońska

Institute of Physics of the Polish Academy of Sciences Warsaw University Of Life Sciences
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Warsaw University Of Life Sciences
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 A NEW GENERATION OF RARE-EARTH-BASED QUANTUM DOTS VS. THEIR
COMMERCIAL COUNTERPARTS FOR APPLICATIONS IN BIOLOGY AND
MEDICINE. THE INFLUENCE OF SHAPE AND SIZE ON INTESTINAL UPTAKE AND
TISSUE DISTRIBUTION OF FLUORESCENT NANOCRYSTALS.

Michał M. Godlewski1,2,, Jaroslaw Kaszewski1,2,4, Anna Szal1,2, Anna Slonska1,2,

Malgorzata A. Domino2,3, Marek Godlewski4
1
Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences –
SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland

: mickgodl@hotmail.com
2
Veterinary Research Centre, Faculty of Veterinary Medicine, Warsaw University of Life Sciences – SGGW,
Nowoursynowska 100, 02-797 Warsaw, Poland
3
Department of Large Animal Diseases with Clinic, Faculty of Veterinary Medicine, Warsaw University of Life
Sciences – SGGW, Nowoursynowska 100, 02-797 Warsaw, Poland
4
Institute of Physics, Polish Academy of Sciences, al. Lotnikow 32/46, 02-668 Warsaw, Poland

Keywords: rare-earth nanocrystals, persorption, blood-brain barrier

Abstract
Biocompatibility of the new generation of rare-earth-based fluorescent nanocrystals (FNs) has already
been confirmed (Godlewski and Godlewski, 2012). Following the intra-gastric gavage (IG), FNs were
quickly absorbed by the small intestine epithelium and rapidly (within 24 h) distributed to the
majority of the organs and tissues. However, when studying the literature, the huge discrepancies have
been found in the distribution patterns of the quantum dots and FNs used by different authors. In this
talk the bioavailability of Eu-doped Y2O3 matrix nanocrystals created using the solvothermal method
in the Institute of Physics will be compared with their commercially-acquired counterparts. The size
and shape of the FNs were examined by the scanning electron microscopy (SEM) and then their
persorption from the duodenum was compared after IG in the adult male Balb-c mice. Furthermore,
the absorption and distribution patterns of two differently-shaped FNs (Eu:Y2O3 and Pr:ZrO2) were
compared.
The IF PAN-made and commercially available Y2O3-based FNs differed significantly in shape and
size. The in-house FNs were small and columnar-shaped compared to the large and spherical
commercial ones. Concomitantly, we found a significantly higher intestinal absorption and
distribution to the liver of the IF PAN-made FNs. To check whether the shape or the size of FNs is the
determining factor in their bioavailability, we performed the experiment with the much smaller
spherical FNs based on ZrO2. We found no differences in the pattern of alimentary uptake or the
distribution to the organs between the IF PAN-made Y2O3 and ZrO2 FNs. In the latter part of the talk
the transfer of the Y2O3 and ZrO2 FNs through the blood-brain barrier will be discussed.

Literature:
M. M. Godlewski and M. Godlewski. Superradiant rare-earth doped nanocrystals in the study of
persorption processes in the adult intestine. In: Current Microscopy Contributions to Advances in
Science and Technology, Microscopy Book Series #5, Ed: A. Méndez-Vilas. Formatex, Spain, 2012:
582-590

Acknowledgments:
This work was supported in part by the grants from:
 European Union within European Regional Development Fund, through grant Innovative
Economy (POIG.01.01.02-00-008/08).
 National Science Centre: DEC-2012/05/E/NZ4/02994
Authors wish to thank the Division of Virology, Department of Preclinical Sciences, Faculty of
Veterinary Medicine, Warsaw University of Life Science for the Balb-c mice.

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