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Acquired Immunity

Hugh B. Fackrell

filename : Kuby 01B7

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Acquired Immunity: Outline

Acquired vs Innate Immunity

Functions of Acquired Immunity
Humoral Immunity: antibody
Cell Mediated Immunity
Role of Macrophages
Regulation of Immunity
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Acquired Immunity: Definitions

Acquired Immunity
Antigen
Immunogen
Humoral Immunity
Cell Mediated Immunity
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Acquired Immunity: Objectives

Define the following terms: Antigen,

immunogen, acquired immunity, humoral
immunity, cell mediated immunity
Identify the cells of the acquired immune
response from light or electron micrographs
Identify the functions of the cells of the acquired
immune reponse
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Acquired Immunity

Definition
Acquired immunity( AKA adaptive immunity)
is an altered reactivity to a specific compound
after exposure to that compound
Characteristics
Specificity
Memory
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Acquired Immunity
Important Features
The altered reactivity will not be to all
compounds, just those compounds to which
the animal has been exposed
The animal has a heightened specific response
on second and subsequent exposures because the
body ” remembers” previous contacts
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Functions of Acquired Immunity

Discriminate between self and non self for:

Defense
destruction of foreign molecules
Homeostasis
removal of dead or damaged cells
Surveillance
control of mutant or cancer cells
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Acquired Immunity has
Two Forms
Humoral Immunity
lymphocytes react INDIRECTLY on non self
molecules via antibodies
Cell Mediated Immunity
Lymphocytes act DIRECTLY on the non self
molecules
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Lymphocytes

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Immunogen vs Antigen

ANTIGEN: combines with the

products of an immune response

IMMUNOGEN:
triggers immunity
and
combines with products

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Antigen: interaction

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Remember

Immunogenicity is not an inherent

characteristic of a molecule
Immunogen MUST first be recognized
as foreign by the body
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Adaptive vs Innate Immunity

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Primary vs Secondary Responses

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Humoral Immunity

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Antibodies Distinguish Between

Diseases
measles & mumps
Macromolecules
proteins, complex carbohydrates
Molecules
amino acids, sugars
Submolecular Structures
D& L isomers; ortho, meta, para positions
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B cell blasts

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B Cell Transformation

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Clonal Selection: B cells

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Immunglobulin on B cells

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Plasma cell function

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Antibody: a Flexible mediator

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Plasma cell: function

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Complement functions

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Cell Mediated Immunity

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T cell blasts

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T cell blasts: structure

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T cells

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Cell mediated clonal selection

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T cell transformation

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T cells ANAE stain

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Role of Macrophages

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Monocyte

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Monocyte structure

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Macrophage Activation products

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Macrophages & T cells

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T cells interacting with
Macrophage

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Macrophage mediatiors:
CD14 receptor

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Macrophage mediators:
CD14 & LPS receptors

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Macrophage mediators:
direct induction

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Oponsization: mechanisms

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Regulation of Immunity

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Range of immune responses

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Antigen Processing

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Cellular interactions during the
humoral response

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A Complete Immune Response

Lymphocytes
B cells
T cells
Macrophages
critical accessory cells
Complement
combines with antibody to enhance destruction
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White Blood Cells

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Adverse effects of Immunity

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The End

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50 Acquired Immunity:
Questions
How does clonal selection contribute to memory
in the immune response?
Name three feature of a secondary immune
response that make it different from a primary
immune response.

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Questions(1)

Interleukin 2 is a nonspecific growth factor

that stimulates the growth of TH cells
during the immune response. In view of this
nonspecificity of IL-2, what mechanism
assures that only TH cells specific for a
given antigen proliferate and that all other
TH cells do not proliferate

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Questions (2)

Antigen presenting cells play a role in both

humoral and cell mediated immune
responses
Name three type af antigen presenting cells
Which class of MHC molecules are expressed
on the membrane of antigen presenting cells?
Which lymphocytes interact eith antigen
presenting cells?

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