PerfectionPeptide P3

Biomimetic peeling for skin rejuvenation

© Mibelle Biochemistry, Switzerland 2018
Desquamation Deteriorates with Age

Young skin Old skin

With age, the desquamation process becomes slow and irregular:

• The skin barrier is weakened (more permeable, water loss occurs)
• Activity of proteases is reduced
• Turnover time of the epidermis starts increasing from the age of 30
 dry, rough and dull skin
© Mibelle Biochemistry, Switzerland 2018
Desquamation

Transit time Desquamation:

1000 cells/cm2/h
~5 x108 cells/day
~14 days
Thickness of the stratum corneum:
15 – 20 cell layers

~14 days

© Mibelle Biochemistry, Switzerland 2018

Desquamation is Mediated by
Corneodesmosomes

• Corneocytes are interconnected by

corneodesmosomes.
• The connection is mainly assured by
desmoglein and desmocollin, two
proteins which constitute
corneodesmosomes.

© Mibelle Biochemistry, Switzerland 2018

Corneodesmosome

© Mibelle Biochemistry, Switzerland 2018

Desmocollin and Desmoglein Form Cell-Cell
Adhesion

• Desmoglein and desmocollin have

a complementary structure.
• They bind together to form bridges
between adjacent corneocytes like a
"key and lock".
• In the outermost parts of the stratum
corneum, these bridges are
degraded by specific proteases,
corneocytes shed invisibly at the skin
surface.

© Mibelle Biochemistry, Switzerland 2018

Structure of Desmoglein

© Mibelle Biochemistry, Switzerland 2018

PerfectionPeptide P3 Comprises the
CAR Site of Desmoglein

© Mibelle Biochemistry, Switzerland 2018

Cell-Cell Adhesion is Weakened

© Mibelle Biochemistry, Switzerland 2018

Keratinocytes are Loosing Contact

© Mibelle Biochemistry, Switzerland 2018

Benefits of PerfectionPeptide P3

• Speeds up epidermal renewal

• Skin is smoothed and radiant
• Does not increase the photosensitivity of the skin  gentle alternative to
chemical / acid peeling
• PerfectionPeptide P3 neutralizes the upregulation of the desmocollin and
desmoglein genes

© Mibelle Biochemistry, Switzerland 2018

PerfectionPeptide P3
Composition
Hexanoyl Dipeptide Norleucine Acetate 0.01%
Lecithin 12.5%
Glycerin 35%
Phenoxyethanol 1%

INCI (EU/PCPC) Declaration

PerfectionPeptide P3 (standard version): Hexanoyl Dipeptide-3 Norleucine
Acetate (and) Lecithin (and) Glycerin (and) Phenoxyethanol (and) Aqua/ Water

PerfectionPeptide P3 Blend (powder version, 20-fold concentrated): Hexanoyl

Dipeptide-3 Norleucine Acetate (and) Isomalt (and) Aqua/Water

Recommended Use Level: 0.5 – 3 %

© Mibelle Biochemistry, Switzerland 2018

Study on Desquamation and Skin Quality

Volunteers 20 women (41 to 58 y)

Products Hydrogels with 1% or 2% PerfectionPeptide P3, placebo
Test area Inner side of the forearm or on the crow‘s feet area (gel with 2%)
Application Twice daily during 4 weeks

Parameters Epidermal turnover time (dansyl chloride)

Hydration
Smoothness
Wrinkle depth (crow‘s feet area)  PRIMOS

© Mibelle Biochemistry, Switzerland 2018

Enhanced Desquamation

1% PerfectionPeptide P3 significantly
increased stratum corneum turnover.

© Mibelle Biochemistry, Switzerland 2018

Increase in Skin Hydration after 14 Days

Significant increase of skin hydration

compared to untreated and placebo.

© Mibelle Biochemistry, Switzerland 2018

Smoothing Effect after 4 Weeks

PerfectionPeptide P3 smoothes the

skin after 28 days (after complete
renewal of the stratum corneum).

© Mibelle Biochemistry, Switzerland 2018

Anti-Wrinkle Effect on the Crow's Feet Area

PerfectionPeptide P3 significantly
reduces the depth of wrinkles in the
crow's feet area.

© Mibelle Biochemistry, Switzerland 2018

Resurfacing Effect of PerfectionPeptide P3

Volunteers 5 women (24 to 62 y, mean: 47 y)

Test products Emulsion with 1% PerfectionPeptide P3, placebo
Application Inner side of the forearm during 17 days

Parameters Skin microrelief - depth and number of wrinkles

- median depth of micro-relief furrows

Cellular cohesion of 3 subjects was analyzed by scanning

electron microscopy.

© Mibelle Biochemistry, Switzerland 2018

Laser Profilometry: Skin Microrelief

© Mibelle Biochemistry, Switzerland 2018

Resurfacing Effect

1% PerfectionPeptide P3 reduced the

depth of furrows and the depth and
number of wrinkles.

© Mibelle Biochemistry, Switzerland 2018

Improvement of Stratum Corneum
Structure
Scanning electron microscopy (tape strips)

Untreated Placebo PerfectionPeptide P3

© Mibelle Biochemistry, Switzerland 2018
PerfectionPeptide P3

• Speeds up cell renewal for a

fresher and more vibrant skin
• Smoothes the skin micro-relief
• Hydrates the skin intensely
• Refines skin texture and reduces
wrinkle depth
• For a more uniform skin that
reflects light with new radiance

© Mibelle Biochemistry, Switzerland 2018

PerfectionPeptide P3
Applications

• Skin refining formulas

• Anti-aging skin care
• Exfoliation/peeling products
• Rejuvenation for face and body
• Problem solver serums
• Foundations

© Mibelle Biochemistry, Switzerland 2018

PerfectionPeptide P3
Marketing Benefits

• Gentle exfoliation, perfect for

sensitive skin
• Physiological peeling
• Ideal to be used on a daily basis
• Tested on the eye contour area
• Maximum perfecting results with
no stress to skin

© Mibelle Biochemistry, Switzerland 2018

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Mibelle Biochemistry
Mibelle AG
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5033 Buchs
Switzerland

Phone number: +41 62 836 17 31

Website: www.mibellebiochemistry.com
Mail: info@mibellebiochemistry.com

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© Mibelle Biochemistry, Switzerland 2018