Name: Bertram, Georgette Eunice

Course & Section: BSN 2-Y1-25

Subject: Pharmacology
Professor: Mr. Renovo Mirador

Using your drug handbook, answer the following questions:

Look for the drug-drug interaction of the following drugs given and give nursing
considerations as you give the drugs together:

1. Celecoxib with ACE inhibitors

- The capacity of NSAIDs to lessen the production of vasodilating renal
prostaglandins is probably connected to the mechanism of these interactions.
Tucatinib's level or effect will be increased by celecoxib. Before and occasionally
throughout treatment, evaluate the affected joints' range of motion, degree of
edema, and level of pain. Examine the patient for sulfonamide, aspirin, or NSAID
allergies. Celecoxib should not be administered to patients with these allergies.
Throughout treatment, check the patient periodically for skin rashes.
2. amitriptyline hydrochloride with barbiturates
- Barbiturates: Increase metabolism and lessen amitriptyline's therapeutic
effectiveness. Monitoring blood pressure and pulse rate in patients with
underlying cardiovascular disease is important while monitoring pharmacological
effects. Especially in older persons, check for orthostatic hypotension. Withhold
the medication if there is a rapid increase or major change in pulse rate or
rhythm, or if systolic blood pressure rises or falls (10–20 mm Hg). Notify the
doctor. -Keep an eye on I&O, particularly bowel habits.
3. acetylcysteine with activated charcoal
- Acetylcysteine (NAC) absorption may be decreased if activated charcoal and oral
acetylcysteine are given at the same time. Data on whether NAC's decreased
bioavailability during the management of drug overdoses is clinically important
are inconclusive. - When inhaled, it may result in chest tightness, sleepiness,
runny nose, and mouth edema. NAC may slow blood coagulation, thus people
with bleeding disorders or those using blood thinners shouldn't take it.
4. budesonide inhalation with ketoconazole
- By changing medication metabolism, budesonide oral will lessen the level of or
action of ketoconazole top. Your body may take longer to break down your
corticosteroid if you use itraconazole, ketoconazole, posaconazole, or
voriconazole. - Modest. When these medications are taken together, there may
be some risk. For more information, speak with your healthcare provider (such as
your doctor or pharmacist). - Your blood's concentration of corticosteroids may
rise.
5. clobazam with hormonal contraceptives
- Clobazam may hasten the rate at which your body breaks down birth control pills.
While taking clobazam, you shouldn't rely on a hormonal contraceptive as your
primary form of birth control. While taking clobazam and for 28 days after
stopping it, you should take an extra, non-hormonal type of birth control.
 6. esmolol hydrochloride with antdiabetic agents
- A beta-blocker called Brevibloc Premixed (esmolol hydrochloride) Injection is
recommended for patients with atrial fibrillation or atrial flutter during
perioperative, postoperative, or other urgent situations in order to quickly reduce
ventricular rate. Brevibloc is also recommended in cases of noncompensatory
sinus tachycardia, where the rapid heartbeat necessitates a particular course of
treatment. Generic Brevibloc is accessible. Cardiogenic shock, first-degree heart
block, sinus bradycardia, cardiac failure, pregnancy (category C), and lactation.
There is no evidence for child safety.
7. indomethacin with aminoglycosides
- Quite Serious. These medications shouldn't often be taken together because
they could combine and have potentially negative effects. For more information,
speak with your healthcare provider (such as your doctor or pharmacist). Your
risk of kidney damage may increase if you take these medications together.
8. isoniazid with acetaminophen
- When taken combined, acetaminophen and isoniazid may change the drug's
effects and have substantial side effects, including potential liver damage. If you
have a fever, chills, joint pain or swelling, extreme fatigue or weakness, unusual
bleeding or bruising, skin rash or itching, appetite loss, nausea, vomiting, or
yellowing of the skin or the whites of your eyes, call your doctor right once.
9. mesalamine with warfarin
- There could be vomiting, nausea, headaches, or diarrhea. Tell your doctor or
pharmacist before taking mesalamine if you have any allergy to it, other
aminosalicylates (such balsalazide, olsalazine), salicylates (like aspirin,
salsalate), sulfasalazine, or any other substances. Inactive chemicals in this
product have the potential to trigger allergic reactions or other issues. To learn
more, speak with your pharmacist.
10. rifampicin with probenecid
- However, the clinical significance of this type of interaction has not been clearly
established. Conversely, oral probenecid significantly raises the serum level of
rifampicin, most likely as a result of a similar depression of hepatic uptake.
Expect the size of urate tophaceous deposits to decrease. The big toe and ear
pinna are the two classic locations, however other tissues such as bursae,
tendons, skin, and kidneys may also be affected.

Give the adverse reactions of the following drugs on the systems indicated:

1. promethazine hydrochloride – metabolic Cimetidine

Gastrointestinal
● Common (1% to 10%): Constipation, diarrhea, flatulence, nausea, vomiting.
● Rare (0.01% to 0.1%): Acute pancreatitis/pancreatitis.
2. Esterified estrogen
Central Nervous System
● Frequency not reported: Migraine, dizziness, headache, exacerbation of epilepsy,
dementia,
chorea.
 3. Gentamicin sulfate
Respiratory
● Frequency not reported: Laryngeal edema, postoperative respiratory distress,
pulmonary
fibrosis, respiratory depression.
4. Iloperidone
EENT
● Common (1% to 10%): Blurred vision, conjunctivitis, nasopharyngitis, nasal
congestion.
5. Meropenem
Central Nervous System
● Common (1% to 10%): Headache.
● Uncommon (0.1% to 1%): Dizziness, seizure, paresthesia, somnolence, syncope,
asthenia.
● Frequency not reported: Hearing loss, other adverse central nervous system (CNS)
experiences.
6. Simvastatin
Respiratory
● Common (1% to 10%): Respiratory tract infection, bronchitis, sinusitis
● Postmarketing reports: Interstitial lung disease
7. Trospium chloride
EENT
● More common: Blurred vision, dry mouth, sleepiness or unusual drowsiness.
● Less common: Dry eyes, sore throat.
● Incidence not known: Dry throat, changes in vision, red, irritated eyes.
8. Desmopressin acetate
Gastrointestinal
● Mild abdominal cramps and nausea in 2% of patients.
● Dyspepsia and vomiting have rarely been associated with DDAVP nasal spray.
9. Ethambutol hydrochloride
Musculoskeletal
● Very rare (less than 0.01%): Joint pain.
10. Promethazine hydrochloride
Metabolic
● Frequency not reported: Anorexia, loss of appetite, appetite stimulation.
REFERENCE:
1. https://www.coursehero.com/file/108524152/BSN-A-1VilladolidCourse-Task/