SpecAWKTM Plus

Chinese Herbal Extration

www.specchemind.com
Index

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Background
Skin aging---Intrinsic & Extrinsic

ROS

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Background

ROS

Inflmamation MAPK Lipid

pathway peroxidation

DNA Amino
Translation MMPS
crosslinking

Collagen
Collagen denaturation-
Melanin Brown yellow
break down
rubbish

Skin ageing, skin is dark yellow without gloss

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Background

Principles of Traditional Chinese Medicine

Traditional Chinese Medicine (TCM) prescriptions usually contain several herbs called a
“fufang”. This formulation is based on the principle of “Jun-Chen-Zuo-Shi(君-臣-佐-使)”.

Jun(emperor) treats the main cause of the disease.

Chen(minister) enhances the actions of “Jun” or treats accompanying symptoms.
Zuo(adjuvant) reduces or eliminates possible toxic effects of the Jun or Chen herbs but also
treats accompanying symptoms.
Shi(courier) helps to deliver or guide the other herbs to the target organs.

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Background
The advantage of Multi-target

Water exchange channel

+ ...
Channel of ions exchange, Na , K ,
+

Channel of sugar entrying

Channel of amino acids movement

.. . .
Channel f or e g uric acid, excretion

.
Channel f or other organic compounds, like medicines, metablization

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Background

The advantage of Multi-target

M1

M2

M3
Three compounds connect diff erent position targets

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Background
The advantage of Multi-target
The shortage of single-target drugs
At the beginning, the antibacterial effect of Penicillinis very good. Thousands of soldiers were saved by
Penicillinis during the World War II.

Dr. Fleming's discovery of penicillin occurred in 1928.

In 1940, Howward Walter Florey from Australia and Boris Ernst Chain from England succeeded in separating the pure
products.
Penicillin was used to treat infections in 1943.
The three men won the Nobel Prize.

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Background
The advantage of Multi-target

Why is the antibacterial effect not as good as it used to be?

A single compound acts on a single target.
Bacterias have evolved to become resistant, they can produce an enzyme which can
hydrolyzes the active structures of penicillin.

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Background
The advantage of Multi-target

Radix isatidis——A representative TCM

It has not been reported to be resistant to antiviral or antimicrobial
action for hundreds of years.
The reason is the multimolecular interaction in Chinese medicine.
Multi-targets attack and inhibit on bacteria.
So it is difficult for bacteria or viruses to establish resistance to multi-
molecule, multi-target drugs.

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Background
The advantage of TCM

Traditional Chinese Medicine from Tu’s winning of Nobel Prize.

Traditional Chinese Medicine is very scientific, safe and effective.

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Key Ingredients
Scutellaria baicalensis Georgi Panax Ginseng Poria cocos extract Lycium Chinese Panax notoginseng
（黄芩） （人参） （茯苓） （枸杞） （三七）

Gastrodia Glycyrrhiza uralensis Licorice Salvia Miltiorrhiza Paeonia Suffruticosa Root Bark Carthamus Tinctorius Flower
（天麻） （甘草） (丹参） （丹皮） （红花）

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
 Key Ingredients

Screening for Best ratio of Extract by Patented Effective

Study 200 TCM
10 years 10 TCM Ethanol technology product

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Identification

TLC HPLC fingerprint

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Identification

Triterpenoid saponin：Ginsenoside, notoginsenoside etc

Flavonoids： Licoflavone

Functions: Strengthening circulation of blood

Anti-inflammation
Anti-oxidation
Whitening
Promote the production of collagen

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Identification

INCI Name：

Panax Ginseng root extract(rensheng）—— Strengthening circulation of blood, Anti-oxidation

Poria cocos sclerotium extract (fuling)—— Anti-inflammation, Astringent

Salvia Miltiorrhiza extract(dansheng）—— Anti-inflammation, Anti-oxidation, Moisture

Paeonia suffruticosa root extract（danpi）—— Anti-inflammation, Strengthening circulation of blood

Panax Notoginseng root extract(sanqi）—— Strengthening circulation of blood, Anti-oxidation

Gastrodia Elata Root Extract(tianma）—— Anti-oxidation, Conditioning

Glycyrrhiza uralensis(Licorice) root extract（gancao）—— Anti-inflammation, Anti-oxidation

Carthamus Tinctorius flower extract(honghua）—— Strengthening circulation of blood, Anti-oxidation

Scutellaria Baicalensis root extract（huangqin）—— Anti-inflammation, Anti-oxidation

Lycium Chinese root extract（gouqi）—— Anti-oxidation

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Efficacy
In-Vitro tests---Promoting collagen synthesis

Result:
Collagen secretion rate increased linearly with increasing concentration, 80.5 ug/mL SpecAWK TM Plus
can promote 50% collagen secretion.

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
 Efficacy

In-Vitro tests-----Anti-oxidation

Anti-Oxidation of SpecAWK TM Plus

120.00% Anti-oxidation
96.00% 95.46%
100.00%
93.15% 95.46% 95.00%
80.00% 94.00% 93.15%
66.95% 93.00%
60.00%
53.90% 92.00% 91.48%
40.00% 91.00%
34.39%
20.00% 90.00%
17.59%
89.00%
0.00% 0.07mg/ml 0.09mg/mL
AWK Plus AWK100umVE
Plus
0.01mg/Ml 0.02mg/Ml 0.03mg/Ml 0.04mg/Ml 0.07mg/ML 0.09mg/Ml

Result:
The best clearance rate of SpecAWKTM Plus is 95.46% at 0.09 mg/mL, it's better than VE（0.043mg/ml）.

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
 Efficacy

In-Vitro test--Inhibit formulation of melanin

Tyrosinase inhibition Melanin inhibition—cell test

0.1
0.09
20.00%
0.08
18.00%
0.07
16.00%
0.06 14.00%
0.05 12.00%
0.04 10.00%
17.94%
0.03 8.00%
6.00% 13.00%
0.02
0.01 4.00%
0 2.00%
Vitamin C SpecAWKTM Plus 0.00%
20ug/ML 200ug/Ml

Result: Result:
Vc≈SpecAWKTMPlus, SpecAWK TMPlus tyrosinase inhibition is Melanin Inhibition rate is 13% at the 20 ug/mL ,17.94%
almost close to VC. at the 200ug/mL.

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Efficacy

In-Vitro test-----Anti-Inflammation
Quantitative analysis of proinflammatory cytokines—— NO, TNF-α and IL-6

Conclusion: The report shows that SpecAWKTM Plus has a significant anti-inflammatory effect.

References: The anti-inflammatory activity of SpecAWKTM plus

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Efficacy

In-ViVo test---Skin Elasticity& Skin Firmness

Product: 5% SpecAWK TM Plus cream

Device: Detection with Cutometer MPA580
Subjects： 20 females
Age range: 35+ years old
Test Site： Face
Period: 8 weeks
Test Parameters：
Skin Elasticity& Skin Firmness
Volunteers’ evaluation
Temperature: 20℃- 25℃;
Humidity: 40% - 60%
Application Frequency：
Twice a day after cleaning face in the morning & evening
References： 5% SPECAWK PLUS elasity and firmness improved test report(5% solution SGS)

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
 Efficacy

In-ViVo test---Skin Elasticity& Skin Firmness

Skin Elasticity Skin Firmness

0.8
0.71 10
0.7 8.92
0.63 9
8.03
0.6 0.55 8
7 6.65
0.5
6
F3/F4 0.4 F4 5
0.3 4
0.2 3
2
0.1
1
0 0
Baseline 4 weeks 8 weeks Baseline 4 weeks 8 weeks

F3/F4 is closer to 1, the skin elasticity is better. The lower the F4, the better the skin firmness.

Result: Result:
Elasticity of skin improved obviously 15% at 4 weeks, Firmness of skin improved obviously 10% at 4 weeks,improved
30% at 8weeks. 25% at 8weeks compared with 0 days.

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Efficacy

In-ViVo test---Skin Smoothness&Wrinkle

Product: 5% SpecAWK TM Plus cream

Device: Detection with Visioscan VC98
Subjects： 20 females
Age range: 35+ years old
Test Site： Face
Period: 8 weeks
Test Parameters：
Skin Smoothness&Wrinkle
Volunteers’ evaluation
Temperature: 20℃- 25℃;
Humidity: 40% - 60%
Application Frequency：
Twice a day after cleaning face in the morning & evening

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
 Efficacy

In-ViVo test---Skin Smoothness&Wrinkle

45.5 Skin Smoothness 42.4

Skin Wrinkle
45.4 42.3

45.3 42.2
Sesm 45.2 SEw
42.1
45.1
42
45
41.9
44.9
44.8 41.8
Baseline 4weeks 8weeks Baseline 4 weeks 8 weeks
The lower the Sesm is, the smoother the skin. The lower the SEw is, the less the skin winkles

Result: Result:
The skin smoothness is improved after 4weeks and The skin wrinkle is improved after 4 weeks,wrinkle
improved 1% at 8 weeks. reduce depend on the time.

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Efficacy

In-ViVo test---Skin gloss& Skin color

Product: 5% SpecAWK TM Plus cream

Device: Skin Color Detection with Colorimeter CL400
Skin Gloss Detection with Glossymeter GL200
Subjects： 20 females
Age range: 35+ years old
Test Site： Face
Period: 8 weeks
Test Parameters：
Skin gloss& Skin color
Volunteers’ evaluation
Temperature: 20℃- 25℃;
Humidity: 40% - 60%
Application Frequency：
Twice a day after cleaning face in the morning & evening
References： 5% SpecAWK plus whitening test(SGS)

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
 Efficacy

In-ViVo test---Skin gloss& Skin color

Skin gloss Skin Color

9 8.4 8.2 42
8 7.5 7.4 40.7
6.9 6.8 41
7
Skin gloss

40
39
6 39 38.18
5
left ITA° 38 37 37.29 left
4 37
3 right 36 right
36
2 35
1 34
0 33
Baseline 4weeks 8weeks Baseline 4weeks 8weeks

Result: Result:
Comparing with pre-treated, Both left and right side improved Comparing with pre-treated,The face both left-right sides
10% at 4 weeks, improved about 20% at 8 weeks. improved 3% at 4 weeks, improved 10 at 8weeks.

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Efficacy

In-ViVo test---Skin lightening

Product: 5% SpecAWK TM Plus cream

Device: Skin Color Detection with Colorimeter CL400
Skin Gloss Detection with Glossymeter GL200
Subjects： 20 females
Age range: 35+ years old
Test Site： Face
Period: 8 weeks
Test Parameters：
Skin lightening
Volunteers’ evaluation
Temperature: 20℃- 25℃;
Humidity: 40% - 60%
Application Frequency：
Twice a day after cleaning face in the morning & evening
References： Spec AWK Plus 0.5%.2.5% lightening Test report(SPEC CHEM)

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Efficacy

In-ViVo test---Skin lightening

Skin lightening
L1 L2 L3 69 69
△L (skin lightness)

66
64
63 63
62 62 62 62
60 60

Baseline 2 weeks 4 weeks 8 weeks

0.5% SpecAWK™ Plus

Result:
Skin lightness increased after 4 weeks, improved about 10% after 8 weeks with 0.5% SpecAWK™ Plus treatment.

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Efficacy

In-ViVo test---Skin lightening

80
69 71
72 71 73 73
△L (skin lightness)

70 64 65 63 63
61 59
60
50 L1
L2
40
L3
30
20
10
0
Baeline 2 weeks 4 weeks 8 weeks

2.5% SpecAWK™ Plus

Result:
Skin lightness improved after 4 weeks and 8 weeks, respectively, skin lightness improved 11.3% at 4
weeks, skin lightness improved 14 % after 8 weeks with 2.5% SpecAWK™ Plus treatment.

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Efficacy
In-ViVo test---Skin lightening

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Efficacy
In-ViVo test --- Volunteers’ self-assessment

After 4 weeks treatment（%）（%） After 8 weeks treatment（%）（%）

Left cheek Right cheek Left cheek Right cheek
Skin gloss 94 94 100 100
Skin brightness 82 82 88 88
Skin smoothness 88 88 100 100
Skin moisture 100 100 100 100
Skin brightening comprehensive
100 100
assessment

After 8 weeks of treatment, the satisfaction of the skin brightening evaluation was 100%.

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Summary

Elastin+

Inflmamation-- Collagen+

Yellowing--
Melanin - Firmness++
Gloss++

Skin Anti-
Roughness- Smoothness+
Whitening++ dullness++

Skin tone
Wrinkle--
up++

Skin Healthy
+++

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Safety

Free from pesticide residue

Heavy metal and microbiology——Pass

No Phototoxicity

References： AWK pesticide residue test 农药残留检测（无农残）En

Heavy metal and microbiology

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Stability
pH(Acid)

Experimental procedure:
Sample dissolved in mixture of
water-ethanol (1/1, V/V), HCl was
added to adjust its pH values

pH=6.5, HPLC analysis, room

temperature

pH=2.0, temperature: 50 ℃
Lasted 2 months.

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Stability

Temperature

Experimental procedure:
Room temperatures.
Lasted two months

50℃
Lasted 2 months

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Formulation
Multi-target natural whitening cream
Product Name INCI Name Dosage(%) Supplier
Cetearyl Glucoside (and)Cetearyl
SpecSufcTM M68 3.5 SC
Alcohol
POTASSSIUM CATYL
SpecSufcTM P1601 1.5 SC
PHOSPHATE
SpecKareTMGTCC Caprylic/Capric Triglyceride 1 SC
CC Carbonicacid,dioctylester 3

A Shea Butter Shea Butter 1 SC

DC200 Dimethicone 2
SpecThemTM C1618 Cetostearyl Alcohol 2 SC
SpecThemTM GMS Glyceryl Monostearate 1 SC
Glyceryl linoleate,Glyceryl
SpecKareTM3GF oleate,Glyceryl linolenate 3 SC

SpecKareTM VEA Tocopheryl Acetate 1 SC

Glycerin Glycerin 1
SpecKareTM NMF50 Betaine 4 SC
SpecKareTM TRHL Trehalose 2 SC
SpecThemTM XTG200 Xanthan Gum 0.15 SC
Water Aqua To 100
B
SpecAWKTM Plus 3
SpecKareTM ALLA Allantion 0.2 SC
EDTA-2Na Disodium EDTA 0.1
SpecWhiteTM VB3 Nicotinamide 1 SC
SpecKareTM HAL Sodium Hyaluronate 1 SC
Sodium Acrylate / Sodium
Acryloyldimethyl Taurate
C SIMULGEL EG 0.5
Copolymer & Isohexadecane&
Polysorbate 80
SpecKareTM NK2 Dipotassium Glycyrrhizinate 0.05 SC
Caprylyl Glycol（and）
D ParbFree® PCG Phenoxyethanol 0.5 SC

Frangace 0.1

References： Multi-target natural whitening cream（3%SpecAWK PLUS）

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Formulation
SpecAWKTM Plus Cream color

SpecAWKTM Plus：0.2% SpecAWKTMPlus ：0.5% SpecAWKTM Plus：1.0%

Color:White Color:White Color:White

SpecAWKTM Plus：1.5% SpecAWKTM Plus：2.0% SpecAWKTMPlus：5.0%

Color:off-White Color:off-White Color:Slight yellow White

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Market products
资生堂悦薇珀翡紧颜亮肤乳
SHISEIDO VITAL-PERFECTION
WHITE REVITALIZING EMULSION
——Panax Ginseng root extract

科颜氏新集焕白均衡亮肤淡斑精
华液
雅诗兰黛肌透修护眼部精华霜
Estee Lauder Advanced Night Repair Eye
KIEHL‘S DERMATOLOGIST
SOLUTIONS CLEARLY
Synchronized Complex II
——Poria cocos sclerotium extract
SpecAWK CORRECTIVE DARK SPOT
TM Plus
S O L U T I O N ——Paeonia
suffruticosa root extract

资生堂百优优效修护精华液
雅诗兰黛肌透修护眼部密集精华露
SHISEIDO BIO-PERFORMANCE
Estee Lauder Advanced Night Repair Eye
SUPER CORRECTIVE SERUM——
Serum Synchronized Complex II——
Carthamus Tinctorius flower extract
Scutellaria Baicalensis root extract

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
Product information

Product Name： SpecAWKTM Plus

INCI Name： References PPT page 16
Dosage： Daily care(anti-aging) products:0.5%.
Repair products (fade lines, wrinkles):1.0%.
Lifting,whitening products:2.5%.
Freckle and anti-wrinkle products:5%.
Usage: It's very stable, it can be added before or after
emulsion.
Package: 1KG/5KG/25KG
Storage： Keep in dark and cool palce
Shelf life： 3 years
Application： Lotion/Emulsion/Serum/Cream

Preservative Free：

SpecAWKTM Plus
Good Quality Comes From Qualified Materials
 Good Quality Comes From
Qualified Materials
Thank you !
In need of samples and technical data,please do not hesitate to contact us.

CONTACT
Email: sc@specchemind.com
Tel: 86 25 84523390, 84523391
Fax: 86 25 84520790, 84520791
No.10 Wanshou Rd, Nanjing P.R. China
Zipcode: 211800