Genomic

1 CYP2D6 with codeine when the effect is reduce?

Poor metabolizer

2 Allopurinol make
severe cutaneous adverse reactions (SCAR)
positive for HLA-B*58:01 allele

3 Which is purine in DNA?

purine [ A,G]
as
4 DNA?
deoxyribonucleic acid

5 Trastuzumab action on breast cencer on which?

HERE2

6 Codeine CYTP2D6 poor metabolizer?

suffer more pain

7 Which one associated with genetic polymorphism?

Warfarin

8 Which one is tumor suppression protein?

P53
9 Question about KRAS and HER2 and what is the treatment?

KRAS
KRAS mutations are associated with CRC prognosis-
- Determine mutation status with tumor KRAS genotyping at diagnosis. Epidermal growth
factor receptor (EGFR) inhibitors should be considered only in patients with tumors with
wild-type KRAS.
EGFR-Inhibitors(Cetuximab, Panitumumab)
Chemotherapeutic Regimens
-FOLFOX plus panitumumab
-FOLFIRI plus cetuximab
-FOLFIRI plus panitumumab
-Cetuximab plus irinotecan
-Panitumumab plus irinotecan
-FOLFOX or capox ± cetuximab or panitumumab
-capox, capecitabine plus oxaliplatin , FOLFIRI, fluorouracil plus leucovorin plus irinotecan;
FOLFOX,fluorouracil plus leucovorin plus oxaliplatin.
-Test tumors for KRAS mutations at diagnosis of stage IV disease; patients with mutations
on codons 12 and 13 on chromosome 12 are not candidates for EGFR inhibitors
HER2
-HER2/neu (HER2) overexpression is associated with transmission of growth signals that
control aspects of normal cell growth and division. Overexpression of HER2 is associated
with increased tumor aggressiveness, rates of recurrence, and mortality
-The use of trastuzumab with chemotherapy is appropriate for patients
With HER2-positive tumors.
-Three anti-HER2 agents are available: trastuzumab, lapatinib, and pertuzumab
-Pertuzumab is a monoclonal antibody that binds to a different HER2 domain as compared
with trastuzumab
10 Which antiviral c combination can be applied to all genotypes?
Sofospuvir and velpatasvir
fo welp
11
Ig
Warfarin drug interaction? CYP2C9
S
Increased INR w/ CYP2C9 (e.g. Amiodarone, capecitabine, cotrimoxazole),

12 Clopidogrel drug interaction? CYP2C19

May reduce antiplatelet effect w/ CYP2C19 inhibitor including PPI (e.g. Esomeprazole,
omeprazole).

13 Abacavir whats gene Of it

HLB b 5701

14 What is two component of purine nitrogen base

Adenine , Guanine

15 What is the basic component of the cell

Cell membrane or plasma, cytoplasm and nucleus

16 CYP2C19
Clopidogrel

17 Patient diagnosed with HIV doctor wants to start treatment among the medication
prescribed was abacavir what is the next step should be taken
Test for HLA-B*5701

18 drug interactions between clopidogrel and omeprazole through which enzyme ?

CYP2C19

19 Pharmacogenomics of cetuximab
KRAS mutation (-ve)

20 allopurinol genetic is HALA_B will be make. side effect of

sever cutaneous

I
21 Carpemazine genitic HALA_B
epidemic necrosis

22 Which of the following is recombint DNA product

8
Livagluaide

23 Ig cannot cross the placenta

Tara scam A
IgA, IgA,IgE .. these cannt cross placenta

24 Clopidogrel interaction omeprazole

Omeprazole and other PPI are Strong CYP2C19 inhibitors reduce antiplatelet effect

25 Abacavir gene
HLA-B 5701

26 Clozapine + smoking
Decrease clozapine plasma
27 what is cytochrome subtype responsible for drug interaction between omeprazol and clopidegrol ?
CYP2C19

28 genetic test for azathioprine

TPMT

29 cytochrome responsible for interaction between omeprazole and clopidogrel

cyp2c19

30 Abacavir test and which class?

HLAB 5701

31 Question about role of RNA ( snRNA)

Proteinsonthi
gg