LCSS Ethyl Acetate - CH3COOC2H5 - PubChem

2/16/22, 7:03 PM Ethyl acetate | CH3COOC2H5 - PubChem
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COMPOUND SUMMARY
Ethyl acetate
PubChem CID 8857
Structure
2D 3D Crystal
Find Similar Structures
Chemical Safety
Flammable Irritant
Laboratory Chemical Safety Summary (LCSS) Datasheet
Molecular Formula C4H8O2 or CH3COOC2H5
ETHYL ACETATE
141-78-6
Ethyl ethanoate
Synonyms Acetic acid ethyl ester
Acetic ether
More...
Molecular Weight 88.11
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Dates
2022-02-14 2004-09-16
Ethyl acetate appears as a clear colorless liquid with a fruity odor. Flash point 24°F. Less dense than water. Vapors heavier than air.
CAMEO Chemicals
Ethyl acetate is the acetate ester formed between acetic acid and ethanol. It has a role as a polar aprotic solvent, an EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor, a metabolite and a
Saccharomyces cerevisiae metabolite. It is an acetate ester, an ethyl ester and a volatile organic compound.
ChEBI
Ethyl acetate is a natural product found in Plectranthus glabratus, Cucumis melo, and other organisms with data available.
LOTUS - the natural products occurrence database
https://pubchem.ncbi.nlm.nih.gov/compound/8857 1/66
1 Structures
1.1 2D Structure
Chemical Structure
Depiction
PubChem
1.2 3D Conformer
PubChem
1.3 Crystal Structures

Showing 1 of 2 View More
CCDC Number 844080
Crystal Structure Data DOI:10.5517/ccxbbdy
Crystal Structure Depiction
Associated Article DOI:10.1021/cg200547k
The Cambridge Structural Database
2 Names and Identifiers
2.1 Computed Descriptors
2.1.1 IUPAC Name
ethyl acetate
Computed by Lexichem TK 2.7.0 (PubChem release 2021.05.07)
PubChem
2.1.2 InChI
InChI=1S/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H3
Computed by InChI 1.0.6 (PubChem release 2021.05.07)
PubChem
2.1.3 InChI Key
XEKOWRVHYACXOJ-UHFFFAOYSA-N
Computed by InChI 1.0.6 (PubChem release 2021.05.07)
PubChem
2.1.4 Canonical SMILES
CCOC(=O)C
Computed by OEChem 2.3.0 (PubChem release 2021.05.07)
PubChem
2.2 Molecular Formula

C4H8O2
CAMEO Chemicals; Wikipedia; PubChem
C4H8O2
CH3COOC2H5
ILO International Chemical Safety Cards (ICSC)
2.3 Other Identifiers
2.3.1 CAS
141-78-6
CAMEO Chemicals; CAS Common Chemistry; ChemIDplus; DTP/NCI; EPA Chemicals under the TSCA; EPA DSSTox; European Chemicals Agency (ECHA); Hazardous Substances Data Bank (HSDB); Human Metabolome D
2.3.2 European Community (EC) Number
205-500-4
European Chemicals Agency (ECHA)
2.3.3 ICSC Number
0367
2.3.4 NSC Number
70930
DTP/NCI
2.3.5 RTECS Number
AH5425000
The National Institute for Occupational Safety and Health (NIOSH)
2.3.6 UN Number
1173
CAMEO Chemicals; DOT Emergency Response Guidebook; ILO International Chemical Safety Cards (ICSC); NJDOH RTK Hazardous Substance List; The National Institute for Occupational Safety and Health (NIOSH)
2.3.7 UNII
76845O8NMZ
FDA/SPL Indexing Data
2.3.8 JECFA Number
27
Joint FAO/WHO Expert Committee on Food Additives (JECFA)
2.3.9 FEMA Number
2414
Flavor and Extract Manufacturers Association (FEMA); Joint FAO/WHO Expert Committee on Food Additives (JECFA)
2.3.10 DSSTox Substance ID
DTXSID1022001
EPA DSSTox
2.3.11 Wikipedia
Ethyl acetate
Wikipedia
2.3.12 RXCUI
1314355
NLM RxNorm Terminology
2.4 Synonyms
2.4.1 MeSH Entry Terms
ethyl acetate
Medical Subject Headings (MeSH)
2.4.2 Depositor-Supplied Synonyms
ETHYL ACETATE Essigester Ethylazetat acetic-acid-ethylester DSSTox_GSID_22001 CAS-141-78-6 ethylactate

141-78-6 EtOAc ethyl-acetate ethyl acetate solution Essigester [German] HSDB 83 ethylacteate
Ethyl ethanoate Aethylacetat CHEBI:27750 CH3COOC2H5 Ethylacetaat [Dutch] Etile (acetato di) [Italian] Etylacetate
Acetic acid ethyl ester Ethylacetat Ethylester kyseliny octove CH3-CO-O-CH3 Aethylacetat [German] FEMA No. 2414 acet-ethylester
Acetic ether 1-acetoxyethane acetic acid ethyl ethyl acetat Caswell No. 429 CCRIS 6036 ehtyl acetate
Acetoxyethane Ethyl ester Ethyl ester of acetic acid 76845O8NMZ Octan etylu [Polish] Ethyle (acetate d') [French] ethanol acetate
Ethyl acetic ester RCRA waste number U112 MFCD00009171 Ethyl acetate (NF) Ethyl acetate (natural) Ethylester kyseliny octove [Czech] ethly acetate
Vinegar naphtha AcOEt NSC 70930 NCGC00091766-01 Acetate d'ethyle EINECS 205-500-4 ethyl acteate
Acetic acid, ethyl ester Ethylacetaat Essigsaeureethylester E1504 Acetato de etilo UN1173 ethyl_acetate
Acetidin Octan etylu UNII-76845O8NMZ DSSTox_CID_2001 Acetate d'ethyle [French] RCRA waste no. U112 ehyl acetate
Ethylacetate Etile (acetato di) Ethyl acetate [NF] Ethyl acetate, ACS reagent Acetato de etilo [Spanish] EPA Pesticide Chemical Code 044003 ethl acetate
Acetic ester Ethyle (acetate d') acetic acid ethylester DSSTox_RID_76453 Ethyl acetate, ACS reagent, >=99.5% ethylaceate ethy acetate
PubChem
3 Chemical and Physical Properties

3.1 Computed Properties
Property Name Property Value Reference
Molecular Weight 88.11 Computed by PubChem 2.1 (PubChem release 2021.05.07)
XLogP3 0.7 Computed by XLogP3 3.0 (PubChem release 2021.05.07)
Hydrogen Bond Donor Count 0 Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07)
Hydrogen Bond Acceptor Count 2 Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07)
Rotatable Bond Count 2 Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07)
Exact Mass 88.052429494 Computed by PubChem 2.1 (PubChem release 2021.05.07)
Monoisotopic Mass 88.052429494 Computed by PubChem 2.1 (PubChem release 2021.05.07)
Topological Polar Surface Area 26.3 Å² Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07)
Heavy Atom Count 6 Computed by PubChem
Formal Charge 0 Computed by PubChem
Complexity 49.5 Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07)
Isotope Atom Count 0 Computed by PubChem
Defined Atom Stereocenter Count 0 Computed by PubChem
Undefined Atom Stereocenter Count 0 Computed by PubChem
Defined Bond Stereocenter Count 0 Computed by PubChem
Undefined Bond Stereocenter Count 0 Computed by PubChem
Covalently-Bonded Unit Count 1 Computed by PubChem
Compound Is Canonicalized Yes Computed by PubChem (release 2021.05.07)
PubChem
3.2 Experimental Properties
3.2.1 Physical Description
Ethyl acetate appears as a clear colorless liquid with a fruity odor. Flash point 24°F. Less dense than water. Vapors heavier than air.
CAMEO Chemicals
DryPowder; Liquid
EPA Chemicals under the TSCA
Liquid
Human Metabolome Database (HMDB)
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.
Colourless liquid, volatile at low temperatures with a fragrant, acetic, ethereal odour
Colorless liquid with an ether-like, fruity odor.
Occupational Safety and Health Administration (OSHA); The National Institute for Occupational Safety and Health (NIOSH)
3.2.2 Color/Form
Clear, volatile
O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 695
Hazardous Substances Data Bank (HSDB)
Colorless liquid
NIOSH. NIOSH Pocket Guide to Chemical Hazards. Department of Health & Human Services, Centers for Disease Control & Prevention. National Institute for Occupational Safety & Health. DHHS (NIOSH) Publication No.
2010-168 (2010). Available from: https://www.cdc.gov/niosh/npg
3.2.3 Odor
CHARACTERISTIC ETHER-LIKE ODOR REMINISCENT OF PINEAPPLE.

Fenaroli's Handbook of Flavor Ingredients. Volume 2. Edited, translated, and revised by T.E. Furia and N. Bellanca. 2nd ed. Cleveland: The Chemical Rubber Co., 1975., p. 157
Fragrant odor
Sax, N.I. Dangerous Properties of Industrial Materials. 6th ed. New York, NY: Van Nostrand Reinhold, 1984., p. 1315
Ether-like, fruity odor
Fruity with a brandy note

Fahlbusch KG et al; Flavors and Fragrances. Ullmann's Encyclopedia of Industrial Chemistry. 7th ed. (1999-2014). New York, NY: John Wiley & Sons. Online Posting Date: 15 Jan 2003
3.2.4 Taste
Pleasant taste when diluted

BITTERSWEET, WINE-LIKE BURNING TASTE.

Ethyl acetate ... contributes a fruity flavor to beer.

Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. 24 789 (1984)
3.2.5 Boiling Point
171 °F at 760 mm Hg (NTP, 1992)

National Toxicology Program, Institute of Environmental Health Sciences, National Institutes of Health (NTP). 1992. National Toxicology Program Chemical Repository Database. Research Triangle Park, North Carolina.
CAMEO Chemicals
77.1 °C
EPA DSSTox; Hazardous Substances Data Bank (HSDB)
Azeotropic mixture with water (6.1% wt/wt), bp: 70.4 °C; azeotropic mixture with water (7.8% wt/wt) and alcohol (9.0% wt/wt), bp: 70.3 °C; Slowly decomposed by moisture, then acquires acid
reaction; absorbs water (up to 3.3% wt/wt)
76.50to77.50°C.@760.00mmHg
The Good Scents Company Information System
77 °C
171°F
3.2.6 Melting Point
-118.5 °F (NTP, 1992)

CAMEO Chemicals
-83.6 °C
EPA DSSTox
-83.8 °C
Haynes, W.M. (ed.). CRC Handbook of Chemistry and Physics. 94th Edition. CRC Press LLC, Boca Raton: FL 2013-2014, p. 3-250
-83.6°C
-84 °C
117°F
Occupational Safety and Health Administration (OSHA)
-117°F
3.2.7 Flash Point
24 °F (NTP, 1992)
CAMEO Chemicals
-4 °C c.c.
24°F
3.2.8 Solubility
50 to 100 mg/mL at 70° F (NTP, 1992)

CAMEO Chemicals
0.91 M
BANERJEE,S (1984)
EPA DSSTox
In water, 8.0X10+4 mg/L at 25 °C

Banerjee S; Environ Sci Technol 18: 587-91 (1984)
Very soluble in water (64 g/L at 25 °C)

Wasik SP et al; Octanol/Water Partition Coefficients and Aqueous Solubilities of Organic Compounds p.66 NBS TR81-2406 (1981)
Miscible with ethanol, ethyl ether; very soluble in acetone, benzene

Miscible with chloroform

For more Solubility (Complete) data for ETHYL ACETATE (6 total), please visit the HSDB record page.
80 mg/mL at 25 °C
Solubility in water, g/100ml at 20 °C: 8.7 (poor)
Slightly soluble in ethanol, ether, glycerol, fixed and volatile oils, soluble in water (1ml in 10ml)
(77°F): 10%
3.2.9 Density
0.902 at 68 °F (USCG, 1999)

U.S. Coast Guard. 1999. Chemical Hazard Response Information System (CHRIS) - Hazardous Chemical Data. Commandant Instruction 16465.12C. Washington, D.C.: U.S. Government Printing Office.
CAMEO Chemicals
0.9003 g/cu cm at 20 °C
DENSITY OF SATURATED AIR (AIR= 1) 1.02; CONVERSION FACTORS: 1 MG/L= 278 PPM; 1 PPM= 3.60 MG/CU M
Clayton, G.D., F.E. Clayton (eds.) Patty's Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994., p. 2978
Relative density (water = 1): 0.9
0.894-0.898
0.90
3.2.10 Vapor Density
3.04 (NTP, 1992) (Relative to Air)

CAMEO Chemicals
3.04 (Air = 1)
Relative vapor density (air = 1): 3.0
3.04
3.2.11 Vapor Pressure
73 mm Hg at 68 °F ; 100 mm Hg at 81° F (NTP, 1992)

CAMEO Chemicals
93.20 mmHg
EPA DSSTox
93.2 mm Hg at 25 °C
Daubert TE, Danner RP; Physical and Thermodynamic Properties of Pure Chemicals Data Compilation. Washington, DC: Taylor and Francis, (1991)
Vapor pressure, kPa at 20 °C: 10
73 mmHg
3.2.12 LogP
0.73 (LogP)
HANSCH,C ET AL. (1995)
EPA DSSTox
log Kow = 0.73

Hansch, C., Leo, A., D. Hoekman. Exploring QSAR - Hydrophobic, Electronic, and Steric Constants. Washington, DC: American Chemical Society., 1995., p. 9
0.73
Human Metabolome Database (HMDB); ILO International Chemical Safety Cards (ICSC)
3.2.13 LogKoa
2.7 (Octanol-Air partition coefficient)
EPA DSSTox
3.2.14 Henrys Law Constant
1.34e-04 atm-m3/mole
EPA DSSTox
Henry's Law constant = 1.34X10-4 atm-cu m/mole at 25 °C

Butler JAV, Tamchandani CN; J Chem Soc: 952-5 (1935)
3.2.15 Atmospheric OH Rate Constant

1.60e-12 cm3/molecule*sec
ATKINSON,R (1989)
EPA DSSTox
3.2.16 Stability/Shelf Life
Slowly decomp by moisture.

3.2.17 Autoignition Temperature
800 °F (USCG, 1999)

CAMEO Chemicals
427 °C
3.2.18 Decomposition
When heated to decomposition it emits acrid smoke and irritating fumes.

Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 1625
On storage, it is slowly decomposed by water.

Snyder, R. (ed.). Ethel Browning's Toxicity and Metabolism of Industrial Solvents. Second Edition. Volume 3 Alcohols and Esters. New York, NY: Elsevier, 1992., p. 234
3.2.19 Viscosity
0.423 mPa.s at 25 °C
3.2.20 Heat of Combustion
2238.1 kJ/mol
3.2.21 Heat of Vaporization
35.60 kJ/mol at 25 °C
3.2.22 Surface Tension
24 DYNES/CM AT 20 °C
U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.
3.2.23 Ionization Potential
10.01 eV
3.2.24 Odor Threshold
Ethyl acetate has a fruity odor and an odor threshold of 3.9 ppm.
Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. 566
Detection in air: 3.6-1.120 mg cu/m

Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. V10 460 (1980)
0.0196 mg/cu m (low odor); 665.0 mg/cu m (high odor); 350 mg/cu m (irritating concn)
Ruth JH; Am Ind Hyg Assoc J 47: A-142-51 (1986)
3.2.25 Refractive Index
Index of refraction = 1.3723 at 20 °C/D

1.371-1.376
3.2.26 Kovats Retention Index
577, 596, 598, 609, 578, 581, 581, 599, 601, 581, 581, 601, 597, 600, 600, 600, 602, 620, 600, 599, 602, 600, 594, 624, 603, 603, 600, 578.95, 597.3, 599.3, 600.8, 604.4, 605.1, 609.7, 611.7,
563, 600, 587, 589, 600, 601, 600, 600, 595, 577, 607, 600, 577, 607, 613, 572, 579, 580, 590, 642, 594, 595.7, 596, 611, 611, 600, 600, 592, 592, 592, 602, 571, 602, 590, 593, 594, 593,
Standard non-polar 589, 592, 587, 590, 591, 594, 592, 594, 597, 602.3, 595, 598.8, 598, 612, 592, 628, 595, 601, 596, 600, 600, 601.82, 600, 604.7, 609, 602, 598, 597, 602, 583, 592, 604, 600, 601, 602, 603,
580, 590, 600, 596, 598, 612, 590, 600, 595, 600, 600, 590, 594, 595, 600, 600, 600, 600, 600, 595, 595, 595, 605, 604, 593, 600, 611, 616, 600, 596, 605, 605, 607, 615, 603, 608, 610,
598.8, 612, 603.8
613, 612, 612, 610, 578, 613, 612, 605, 615, 615, 615, 608, 621, 612, 610, 614, 609.1, 623, 615, 605, 612, 628, 614, 626, 612, 612, 614, 617, 612, 601, 606, 600, 602.4, 605.7, 607.5, 618,
567, 633, 611, 607, 612, 606, 604, 607, 599, 628, 609, 605, 616, 592, 605, 600, 613, 584, 613, 628, 605, 612, 634, 614, 584, 584, 608, 605, 615, 608, 584, 628, 628, 615, 615, 602, 609, 611,
Semi-standard non-polar
612, 612, 621, 623.5, 613, 592, 613, 617.5, 611, 611, 615, 616.4, 631.3, 630, 595, 613, 613, 615, 615, 614, 631.9, 592, 614, 615, 610.1, 619.2, 620, 590, 615, 616, 588, 620, 568, 614, 595,
614, 603, 600, 554
899, 891, 893, 896, 899, 896, 889, 872, 891, 894, 889, 900, 886, 914, 890, 908, 874, 904, 893, 900, 878, 900, 898, 893, 870, 892, 901, 904, 888, 901, 880, 912.4, 900, 894, 870, 891, 863,
891, 882, 863, 887, 888, 888, 890, 902, 907, 885, 884, 870, 870, 872, 867, 867, 881, 890, 893, 868, 854, 882, 892, 881, 880, 866, 890, 885, 902, 884, 887, 906, 874, 875, 880, 881, 908, 880,
880, 870, 906, 856, 858, 882, 889, 895, 900, 917, 898, 903, 862, 907, 870, 885, 870, 915, 894, 896, 909, 892, 895, 898, 861, 885, 882, 890, 885, 904, 871, 885, 885, 891, 893, 877, 872, 897,
Standard polar 898, 885, 898, 892, 878, 885, 892, 900, 892, 891, 868, 866, 866, 898, 889, 900, 853, 905, 872, 898, 900, 898, 891, 899, 890, 890, 885, 893, 893.3, 872, 890, 880.8, 856, 898, 902.3, 883.9,
885, 891, 897.9, 900, 901, 908, 893, 893, 892, 890, 903, 921, 882, 893, 904.2, 850, 884, 889, 920, 890, 885, 895.1, 850, 872, 850, 887.5, 895, 861, 870, 882, 894, 883, 895, 885, 908, 854,
886, 895, 882.1, 900, 878, 890, 877, 872, 882, 912, 885, 872.7, 888, 888, 900, 872, 882, 882, 877, 882, 879, 882, 886, 887, 889, 889, 890, 890, 872, 880, 873, 888, 891, 880, 872, 880, 872,
872, 883, 906.4, 886, 889, 906, 882, 870, 872, 857, 858, 878
NIST Mass Spectrometry Data Center
3.2.27 Other Experimental Properties
ACID VALUE NOT MORE THAN 0.01%

DISTILLS BETWEEN 76 & 77.5 °C

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1232
Specific gravity: 0.902 at 20 °C/4 °C; 0.898 at 25 °C/25 °C

More soluble (in water) at lower temperatures and less soluble at higher temperatures.
For more Other Experimental Properties (Complete) data for ETHYL ACETATE (8 total), please visit the HSDB record page.
3.3 SpringerMaterials Properties

Schoenflies notation Diffusion Mixing enthalpy Thermal conductivity
Activity Diffusive flux Molecular structure Thermal expansion coefficient
Azeotropes Excess enthalpy Optical coefficient Transition enthalpy
Boiling point Excess volume Phase diagram Vapor pressure
Chemical bond Fusion temperature Phase equilibrium Vapor-liquid equilibrium
Chemical diffusion Heat capacity Phase transition Virial coefficient
Chemical shift Heat of solution Point group Viscosity
Composition Heat of sublimation Refractive index
Compressibility Internuclear distance Solid-liquid phase equilibrium
Critical point Latent heat Sound absorption
Density Lineshape Sound propagation
Diamagnetic susceptibility Magnetic susceptibility Sound velocity
Dielectric constant Melting temperature Surface tension
SpringerMaterials
4 Spectral Information
4.1 1D NMR Spectra
1D NMR Spectra 1H NMR: 79 (Varian Associates NMR Spectra Catalogue)
1D NMR Spectra NMRShiftDB Link
NMRShiftDB
4.1.1 1H NMR Spectra
Instrument Name BRUKER AC-300
Source of Sample Fluka AG, Buchs, Switzerland
Copyright Copyright © 1991-2021 John Wiley & Sons, Inc. All Rights Reserved.
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Instrument Name Bruker WM-300
Copyright Copyright © 2002-2021 Wiley-VCH Verlag GmbH & Co. KGaA. All Rights Reserved.
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SpectraBase
4.1.2 13C NMR Spectra
Source of Sample Dodge & Olcott, Inc., New York, New York
Copyright Copyright © 1980, 1981-2021 John Wiley & Sons, Inc. All Rights Reserved.
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SpectraBase
Instrument Name BRUKER AM-360
Copyright Copyright © 2002-2021 Wiley-VCH Verlag GmbH & Co. KGaA. All Rights Reserved.
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SpectraBase
4.1.3 17O NMR Spectra
Copyright Copyright © 2016-2021 W. Robien, Inst. of Org. Chem., Univ. of Vienna. All Rights Reserved.
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Copyright Copyright © 2016-2021 W. Robien, Inst. of Org. Chem., Univ. of Vienna. All Rights Reserved.
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SpectraBase
4.2 Mass Spectrometry
4.2.1 GC-MS
MoNA ID JP001519
MS Category Experimental
MS Type GC-MS
MS Level MS1
Instrument HITACHI RMU-6M
Instrument Type EI-B
Ionization Mode positive
Top 5 Peaks 43 100

29 1.7
45 1.4
61 1.1
70 1.0
SPLASH splash10-0006-9000000000-f48a6e770df57144ce33
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Submitter University of Tokyo Team, Faculty of Engineering, University of Tokyo
MassBank of North America (MoNA)
MoNA ID JP001797
MS Category Experimental
MS Type GC-MS
MS Level MS1
Ionization Mode positive
43 100
29 15.8
Top 5 Peaks 45 14.5
61 13.8
70 8.8
SPLASH splash10-0006-9000000000-4fbfd506d2d6d053e57f
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Submitter University of Tokyo Team, Faculty of Engineering, University of Tokyo
MassBank of North America (MoNA)
4.2.2 Other MS
Other MS MASS: 37170 (NIST/EPA/MSDC Mass Spectral Database, 1990 version)
Accession ID JP001519
Authors YAMAMOTO M, DEP. CHEMISTRY, FAC. SCIENCE, NARA WOMEN'S UNIV.
MS Level MS
Ionization Mode POSITIVE
Ionization ENERGY 70 eV
43 999
29 17
Top 5 Peaks 45 14
15 14
61 11
SPLASH splash10-0006-9000000000-f48a6e770df57144ce33
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License CC BY-NC-SA
MassBank Europe
4.3 UV Spectra
MAX ABSORPTION (METHANOL): 209 NM (LOG E= 1.86); SADTLER REFERENCE NUMBER: 4 (IR, PRISM); 3 (IR, GRATING)
Weast, R.C. (ed.). Handbook of Chemistry and Physics. 60th ed. Boca Raton, Florida: CRC Press Inc., 1979., p. C-86
UV: 4-21 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons, New York)
Lide, D.R., G.W.A. Milne (eds.). Handbook of Data on Organic Compounds. Volume I. 3rd ed. CRC Press, Inc. Boca Raton ,FL. 1994., p. V1: 133
4.4 IR Spectra
IR Spectra IR: 4802 (Coblentz Society Spectral Collection)
4.4.1 FTIR Spectra
Instrument Name DIGILAB FTS-40
Technique NEAT
Source of Sample J. T. Baker Chemical Company
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Technique CAPILLARY CELL: NEAT
Source of Sample Dodge & Olcott, Inc., New York, New York
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4.4.2 ATR-IR Spectra
Technique ATR-Neat
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Instrument Name Bruker Tensor 27 FT-IR
Technique ATR-Neat (DuraSamplIR II)
Source of Spectrum Bio-Rad Laboratories, Inc.
Source of Sample TCI Chemicals India Pvt. Ltd.
Catalog Number A0030
Lot Number DLAEG-AQ
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SpectraBase
4.4.3 Near IR Spectra

Instrument Name INSTRUMENT PARAMETERS=INST=BRUKER,RSN=10891,REO=2,CNM=HEI,ZFF=2
Technique NIR Spectrometer= BRUKER IFS 88
Source of Spectrum Prof. Buback, University of Goettingen, Germany
Copyright Copyright © 1989, 1990-2021 Wiley-VCH Verlag GmbH & Co. KGaA. All Rights Reserved.
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Instrument Name INSTRUMENT PARAMETERS=INST=BRUKER,RSN=10891,REO=2,CNM=HEI,ZFF=2
Technique NIR Spectrometer= BRUKER IFS 88
Source of Spectrum Prof. Buback, University of Goettingen, Germany
Copyright Copyright © 1989, 1990-2021 Wiley-VCH Verlag GmbH & Co. KGaA. All Rights Reserved.
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4.4.4 Vapor Phase IR Spectra
Instrument Name DIGILAB FTS-14
Technique Vapor Phase
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Technique Vapor Phase
Source of Spectrum Sigma-Aldrich Co. LLC.
Source of Sample Sigma-Aldrich
Catalog Number 154857
Copyright Copyright © 2018-2021 Sigma-Aldrich Co. LLC. - Database Compilation Copyright © 2018-2021 John Wiley & Sons, Inc. All Rights Reserved.
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SpectraBase
4.5 Raman Spectra

Raman Spectra Raman: 28 (Sadtler Research Laboaratories spectral collection)
Instrument Name Thermo Nicolet FT-Raman 960
Technique FT-Raman
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SpectraBase
4.6 Other Spectra

Intense mass spectral peaks: 43 m/z, 61 m/z, 70 m/z, 73 m/z, 88 m/z
Pfleger, K., H. Maurer and A. Weber. Mass Spectral and GC Data of Drugs, Poisons and their Metabolites. Parts I and II. Mass Spectra Indexes. Weinheim, Federal Republic of Germany. 1985., p. 100
5 Related Records
5.1 Related Compounds with Annotation
PubChem
5.2 Related Compounds

Same Connectivity 18 Records
Same Parent, Connectivity 222 Records
Same Parent, Exact 203 Records
Mixtures, Components, and

8,163 Records
Neutralized Forms
Similar Compounds 138 Records
Similar Conformers 4,280 Records
PubChem
5.3 Substances
5.3.1 Related Substances
All 10,536 Records
Same 915 Records
Mixture 9,621 Records
PubChem
5.3.2 Substances by Category
PubChem
5.4 Entrez Crosslinks

PubMed 7,591 Records
Protein Structures 7 Records
Taxonomy 2 Records
Gene 5 Records
PubChem
5.5 NCBI LinkOut
NCBI
6 Chemical Vendors
PubChem
7 Drug and Medication Information

7.1 FDA National Drug Code Directory
ETHYL ACETATE is an active ingredient in the product 'Household Antigens'.
National Drug Code (NDC) Directory
7.2 Therapeutic Uses

Anti-Arrhythmia Agents
National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)
... It has been used internally in a dose of 1 to 2 cc as carminative & antispasmodic, also externally as counterirritant ... .
Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 412
8 Food Additives and Ingredients
8.1 Food Additive Classes

Flavoring Agents
EU Food Improvement Agents; Joint FAO/WHO Expert Committee on Food Additives (JECFA)
8.2 FEMA Flavor Profile

Aromatic, Brandy, Grape
Flavor and Extract Manufacturers Association (FEMA)
8.3 FDA Substances Added to Food

Substance ETHYL ACETATE
Used for (Technical Effect) SOLVENT OR VEHICLE
73.1
172.560
172.859
Document Number (21 CFR) 173.228
175.320
177.1200
182.60
FDA Center for Food Safety and Applied Nutrition (CFSAN)
8.4 FDA Indirect Additives used in Food Contact Substances

Indirect Additives ETHYL ACETATE
172.560
172.859
173.228
Title 21 of the U.S. Code of
Federal Regulations (21 175.320
CFR)
177.1200
182.60
73.1
8.5 Food Additive Status

FDA Food Additive Status
Ethyl acetate - SY/FS, MISC, REG, GMP, GRAS - 182.60, In decaffeination of coffee & tea - 173.228
9 Pharmacology and Biochemistry
9.1 Absorption, Distribution and Excretion

... The primary route of absorption responsible for the toxicity of ethyl acetate is inhalation.
Ryan, R.P., C.E. Terry (eds.). Toxicology Desk Reference 4th ed. Volumes 1-3. Taylor & Francis, Washington, D.C. 1997., p. 1253
9.2 Metabolism/Metabolites
... The current study was aimed at quantitating the extent of metabolism of inspired ethyl acetate in the upper respiratory tract (URT) of the F344 rat and Syrian hamster. Ethyl acetate
deposition was measured in the surgically isolated URT of these species under constant velocity unidirectional flow conditions. The degree of metabolism was estimated by mathematic
modeling based on a simple venous-equilibration approach and by direct comparison of deposition efficiencies in naive and carboxylesterase-inhibited animals. Ethyl acetate deposition
efficiencies averaged between 10 and 35% in the rat URT and 36 and 72% in the hamster. Carboxylesterase inhibition decreased deposition in both species. Both the modeling efforts and the
direct comparisons between naive and inhibited animals indicated that significant amounts of the deposited ethyl acetate were metabolized in the URT of both species with the extent of
metabolism being more pronounced in the hamster. Specifically, 40-65% of the deposited ethyl acetate was metabolized in the URT of the rat compared to 63-90% in the hamster. This first-
pass metabolism (i) increased URT deposition efficiencies; (ii) led to production of high metabolite levels in URT tissues; and (iii) decreased the amount of parent ethyl acetate available for
absorption into the bloodstream in the URT.
PMID:2300973
Morris JB; Toxicol Appl Pharmacol 102 (2): 331-345 (1990)
Because of the abundance of nonspecific esterases, one might expect the common solvent ethyl acetate (EtAc) to be hydrolyzed to ethyl alcohol (EtOH) in vivo. It would then be possible to
demonstrate EtOH accumulation following exposure to EtAc vapor. Preliminary studies showed that rat blood incubated at 37 °C does hydrolyze EtAc to EtOH, with a half-time of approximately
65 min. Analyses were done by gas chromatography. To study this reaction in vivo, rats were anesthetized with pentobarbital, and cannulae were inserted into the femoral arteries. EtAc was
injected ip as a 25% () solution in corn oil (1.6 g/kg) and blood samples were drawn periodically. Hydrolysis was very rapid in vivo, with a half-time estimated at 5-10 min. Inhalation studies
were then carried out by exposing anesthetized rats to several concentrations of EtAc vapor via an endotracheal tube. When EtAc concentrations were increased above 2000 ppm, EtAc
absorption exceeded EtOH oxidation, leading to an accumulation of EtOH in the blood. Although blood EtOH concentrations increased steadily to over 0.10 g/100 mL in 5 hr, EtAc remained
consistently below 0.01 g/100 mL and did not change throughout the course of the experiment, again indicating rapid hydrolysis. The data indicate that EtOH will accumulate during exposure
to EtAc if the ambient concentration of EtAc is sufficiently high.
Gallaher EJ, Loomis TA; Toxicol Appl Pharmacol 34 (2): 309-313 (1975)
... Ethyl acetate ... metabolism produces corresponding ethyl alcohol & is partly excreted in exhaled air & urine & partly metabolized.
Metabolic studies in the rat have revealed an approximate 2000 ppm no-effect level. At higher levels, the rate of hydrolysis of ethyl acetate appeared to exceed ethanol oxidation, leading to its
accumulation in the vascular system. Also, when it was injected intraperitoneally at 1.6 g/kg, hydrolysis to acetic acid and ethanol occurred rapidly. Intraperitoneal injections of 1 mL/kg to male
rats for 8 days increased the blood pyruvic and lactic acid content considerably and also elevated the glycolytic enzymatic activity.
9.3 Human Metabolite Information
9.3.1 Cellular Locations
Cytoplasm
Extracellular
9.4 Biochemical Reactions
Rhea - Annotated Reactions Database
10 Use and Manufacturing
10.1 Uses
EPA CPDat Chemical and Product Categories
The Chemical and Products Database, a resource for exposure-relevant data on chemicals in consumer products, Scientific Data, volume 5, Article number: 180125 (2018), DOI:10.1038/sdata.2018.125
EPA Chemical and Products Database (CPDat)
For ethyl acetate (USEPA/OPP Pesticide Code: 044003) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so
federal, state and local authorities must be consulted for currently approved uses./
National Pesticide Information Retrieval System's Database on Ethyl Acetate (141-78-6). Available from, as of June 12, 2014: https://npirspublic.ceris.purdue.edu/ppis/
The active ingredient is no longer contained in any registered pesticide products ... "cancelled."
USEPA/OPP; Status of Pesticides in Registration, Reregistration and Special Review p.292 (Spring, 1998) EPA 738-R-98-002
Pharmaceutic acid (flavor); artificial fruit essences. Extraction medium and chromatography reagent. Organic solvent for nitrocellulose, varnishes, lacquers, and aeroplane dopes; manufacturing
smokeless powder, artificial leather, photographic films and plates, artificial silk, perfumes; cleaning textiles, etc.
SOLVENT FOR COATINGS (EG, SHELLAC) & PLASTICS (EG, VINYL RESINS); OTHER SOLVENT USES (EG, INKS); CHEM INTERMEDIATE; AROMA ENHANCER IN GRAPE BEVERAGES.
SRI
For more Uses (Complete) data for ETHYL ACETATE (12 total), please visit the HSDB record page.
10.1.1 Use Classification
Food additives -> Flavoring Agents
EU Food Improvement Agents
Flavoring Agents -> JECFA Flavorings Index
Fire Hazards -> Flammable - 3rd degree
NJDOH RTK Hazardous Substance List
Cosmetics -> Solvent

S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118
NORMAN Suspect List Exchange
10.1.2 Industry Uses
Adhesives and sealant chemicals

Bonding
Functional fluids (closed systems)
Laboratory chemicals
Paint additives and coating additives not described by other categories
Pigments
Plasticizers
Process regulators
Processing aids, not otherwise listed
Solvents (for cleaning and degreasing)
Solvents (which become part of product formulation or mixture)
Surface active agents
Viscosity adjustors
https://www.epa.gov/chemical-data-reporting
10.1.3 Consumer Uses
Adhesive Tape
Adhesives and sealants
Air care products
Automotive care products
Cleaning and furnishing care products
Electrical and electronic products
Explosive materials
Ink, toner, and colorant products
Non-TSCA use
Paints and coatings
Personal care products
Plastic and rubber products not covered elsewhere
10.1.4 Household Products
Household & Commercial/Institutional Products
Information on 91 consumer products that contain Ethyl acetate in the following categories is provided:
• Auto Products
• Hobby/Craft
• Home Maintenance
• Inside the Home
• Personal Care
Consumer Product Information Database (CPID)
10.2 Methods of Manufacturing

Ethyl acetate is produced commercially by the Tischenko condensation of acetaldehyde using an aluminum ethoxide catalyst.
Hagemeyer HJ; Acetaldehyde. Kirk-Othmer Encyclopedia of Chemical Technology (1999-2014). John Wiley & Sons, Inc. Online Posting Date: April 28, 2014
Co-product of butane oxidation to acetic acid at 175 °C and 50 atm in the presence of catalytic cobalt and chromium ions; co-product of the ethanolysis of polyvinyl acetate to polyvinyl
alcohol.
Chemical Products Synopsis: Ethyl Acetate (1983)
Acetaldehyde (Tishchenko reaction); ethanol + acetic acid (esterification); polyvinyl acetate + ethanol (transesterification; byproduct of polyvinyl alcohol reaction).
Ashford, R.D. Ashford's Dictionary of Industrial Chemicals. London, England: Wavelength Publications Ltd., 1994., p. 387
By heating acetic acid and ethyl alcohol in the presence of sulfuric acid and distilling.
Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 517
10.3 Impurities
In the 85-88% grade, the major constituent other than ethyl acetate is ethanol.
CHEMICAL PRODUCTS SYNOPSIS: Ethyl Acetate (1983)
10.4 Formulations/Preparations
Grades: Commercial, 85-88%; 95-98%; 99%; NF /National Formulary/ (99%); FCC /Food Chemical Codex/.
Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 517
Nail polish remover typically 40 wt% ethyl acetate.

Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. V7 163
10.5 Consumption Patterns

SOLVENT FOR: COATINGS (EG, SHELLAC), 65%; PLASTICS (EG, VINYL RESINS), 12%; OTHER SOLVENT USES (EG, INKS), 20%; CHEM INTERMEDIATE, 3% (1983)
SRI
Lacquers and enamels, 60%; inks, 15%; miscellaneous, 25% (1983) /estimate/
CHEMICAL PRODUCTS SYNOPSIS: Ethyl Acetate (1983)
CHEMICAL PROFILE: Ethyl Acetate. Coatings solvent, 40%; exports, 38%; miscellaneous solvent uses, 12%; plastics, 8%; chemical synthesis, 2%.
Kavaler AR; Chemical Marketing Reporter 235 (2): 46 (1989)
CHEMICAL PROFILE: Ethyl acetate. Demand: 1988: 210 million lb; 1989: 210 million lb; 1993 /projected/: 220 million lb. (Includes exports, but not imports, which totaled 30 million lb last year.)
Kavaler AR; Chemical Marketing Reporter 235 (2): 46 (1989)
CHEMICAL PROFILE: Ethyl Acetate. Demand, million pounds: 325 in 1996, 335 in 1997, est 400 in 2001 (includes exports of 100 to 125 million pounds; but not imports in the range of 20 million
to 30 million pounds annually). Uses: coatings solvent, 60%; process solvent, including pharmaceuticals and organic synthesis, 15%; inks solvent, 15%; miscellaneous solvent uses, including
adhesives and cosmetics, 10%.
Kavaler AR; Chemical Marketing Reporter, Oct 6, 1997 (1997)
10.6 U.S. Production

Aggregated Product Volume (EPA CDR 2016)
100,000,000 - 250,000,000 lb
(1978) 8.26X10+10 G
SRI
(1982) 1.07X10+11 G
SRI
(1985) 8.71X10+10 g
USITC. SYN ORG CHEM-U.S. PROD/SALES p.266 (1985)
(1986) 1.92X10+8 lb
USITC. SYN ORG CHEM-U.S. PROD/SALES. PRELIMINARY p.C/P-87-5 (1986)
For more U.S. Production (Complete) data for ETHYL ACETATE (8 total), please visit the HSDB record page.
10.7 U.S. Imports

(1978) 2.90X10+9 G
SRI
(1982) 5.15X10+9 G
SRI
(1985) 4.40X10+9 g
BUREAU OF THE CENSUS. U.S. IMPORTS FOR CONSUMPTION AND GENERAL IMPORTS p.1-582 (1985)
(1986) 9.14X10+6 lb
BUREAU OF THE CENSUS. US IMPORTS FOR CONSUMPTION AND GENERAL IMPORTS P. 1-528 (1986)
10.8 U.S. Exports

(1978) 2.88X10+10 G
SRI
(1982) 4.99X10+10 G
SRI
(1985) 3.53X10+10 g
BUREAU OF THE CENSUS. U.S. EXPORTS, SCHEDULE E, p.2-77 (1985)
(1987) 6.8X10+7 lb
BUREAU OF THE CENSUS. U. S. EXPORTS, SCHEDULE E, P.2-80 (OCTOBER 1987)
(1988) 3.23X10+6 lb
BUREAU OF THE CENSUS. U. S. EXPORTS, SCHEDULE E, P.2-59 (JANUARY 1988)
10.9 General Manufacturing Information

Industry Processing Sectors
Adhesive manufacturing Printing and related support activities

All other basic organic chemical manufacturing Printing ink manufacturing
All other chemical product and preparation manufacturing Services
Computer and electronic product manufacturing Soap, cleaning compound, and toilet preparation manufacturing
Electrical equipment, appliance, and component manufacturing Synthetic dye and pigment manufacturing
Explosives manufacturing Textiles, apparel, and leather manufacturing
Food, beverage, and tobacco product manufacturing Transportation equipment manufacturing
Furniture and related product manufacturing Wholesale and retail trade
Miscellaneous manufacturing
Paint and coating manufacturing
Pharmaceutical and medicine manufacturing
Plastic material and resin manufacturing
Plastics product manufacturing
EPA TSCA Commercial Activity Status
Acetic acid ethyl ester: ACTIVE

https://www.epa.gov/tsca-inventory
Volatile constituent of essential oils obtained from fruits and flowers, e.g., ... in wines, brandy, and in fruits such as pineapples
Sakamuri R; Esters, Organic. Kirk-Othmer Encyclopedia of Chemical Technology. (1999-2014). New York, NY: John Wiley & Sons. Online Posting Date: 19 Dec 2003
10.10 Sampling Procedures

Ethyl acetate vapors are adsorbed onto silica gel contained in a lightweight aluminum alloy sampling tube for use in desorption and analytical techniques.
PMID:1008405
LEE GL, WALDRON T; ANN OCCUP HYG 19 (2): 129 (1976)
The field data of solvent concentrations were determined using active and passive samplers, and compared to values obtained from urinary analyses. Active samplers were taken by activated
charcoal tubes; passive samples were taken by the TK200 passive dosimeters. /It was concluded/ that passive dosimeters are reliable and represent a viable alternative for determination of
solvents in air.
PMID:3777749
Bartolucci GB; Ann Occup Hyg 30 (3): 295-306 (1986)
11 Identification
11.1 Analytic Laboratory Methods
Method: NIOSH 1457, Issue 1; Procedure: gas chromatography with flame ionization detector; Analyte: ethyl acetate; Matrix: air; Detection Limit: 0.5 ug/sample.
CDC; NIOSH Manual of Analytical Methods, 4th ed. Ethyl Acetate (141-78-6). Available from, as of June 13, 2014: https://www.cdc.gov/niosh/docs/2003-154/
Method: OSHA 7; Procedure: gas chromatography with flame ionization detector; Analyte: ethyl acetate; Matrix: air; Detection Limit: Not reported.
U.S. Department of Labor/Occupational Safety and Health Administration's Index of Sampling and Analytical Methods. Ethyl Acetate (141-78-6). Available from, as of June 16, 2014:
https://www.osha.gov/dts/sltc/methods/toc.html
AOAC Method 972.10. Alcohols (Higher) and Ethyl Acetate in Distilled Liquors. Alternative Gas Chromatographic Method.
Association of Official Analytical Chemists. Official Methods of Analysis. 15th ed. and Supplements. Washington, DC: Association of Analytical Chemists, 1990, p. 700
AOAC Method 968.09. Alcohols (Higher) and Ethyl Acetate in Distilled Liquors. Gas Chromatographic Method.
Association of Official Analytical Chemists. Official Methods of Analysis. 15th ed. and Supplements. Washington, DC: Association of Analytical Chemists, 1990, p. 700
For more Analytic Laboratory Methods (Complete) data for ETHYL ACETATE (8 total), please visit the HSDB record page.
11.2 Clinical Laboratory Methods

Confirmation of ethyl acetate was obtained with static headspace gas chromatography with mass spectrometry. In blood, rapid biotransformation of ethyl acetate occurs by plasma esterases
resulting in acetic acid and ethanol. Quantitation of ethyl acetate and ethanol in the postmortem samples was performed using static headspace gas chromatography with flame ionization
detector. N-butanol was used as internal standard. Separation of the compounds was obtained on a Supelcowaxtrade mark-10 Fused Silica capillary column. The method was linear over the
specific ranges investigated and showed a within-run accuracy of 99.8 and 101.0% and a precision of 0.5 and 2.0% for ethanol and ethyl acetate, respectively. The postmortem samples were
analyzed in duplicate or triplicate. Coefficients of variation were < or =4.51% for ethyl acetate and < or =0.52% for ethanol...
Coopman VA, et al; Forensic Sci Int. 2005, 154(2-3):92-5 (2005).
When gas chromatographic-mass spectroscopy was used in analysis, ethyl acetate was detected in all blood samples & brain tissues. The curves of blood ethyl alcohol concn vs blood pH
values showed a regression distribution pattern. These results may be used in forensic investigations.
KOJIMA T ET AL; NIPPON HOIGAKU ZASSHI 34 (5): 587-95 (1980)
Detection & identification of volatile organic compounds, including ethyl acetate, in whole blood, plasma, or serum by headspace gas chromatography as an aid to the diagnosis of solvent
abuse.
PMID:7096519
RAMSEY JD, FLANAGAN RJ; J CHROMATOGR 240 (2): 423-44 (1982)
11.3 OSHA Chemical Sampling

GC-FID - OSHA 5000 (fully validated)
11.4 NIOSH Analytical Methods

ETHYL ACETATE 1457
NIOSH Manual of Analytical Methods
VOLATILE ORGANIC COMPOUNDS (SCREENING) 2549
NIOSH Manual of Analytical Methods
12 Safety and Hazards
12.1 Hazards Identification
12.1.1 GHS Classification
Pictogram(s)
Flammable Irritant
Signal Danger
H225: Highly Flammable liquid and vapor [Danger Flammable liquids]

GHS Hazard Statements H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]
Precautionary Statement P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P312, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501
Codes
(The corresponding statement to each P-code can be found at the GHS Classification page.)
EU REGULATION (EC) No 1272/2008
12.1.2 Hazard Classes and Categories
Flam. Liq. 2
STOT SE 3
Eye Irrit. 2
EU REGULATION (EC) No 1272/2008
Flammable liquid - category 2

Specific target organ toxicity (single exposure) - category 3
Eye irritation - category 2A
Hazardous Chemical Information System (HCIS), Safe Work Australia
12.1.3 NFPA Hazard Classification
3
1 0
NFPA 704 Diamond
1-3-0
NFPA Health Rating 1 - Materials that, under emergency conditions, can cause significant irritation.
3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures
NFPA Fire Rating
or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.
NFPA Instability Rating 0 - Materials that in themselves are normally stable, even under fire conditions.
12.1.4 Health Hazards
Headache, irritation of respiratory passages and eyes, dizziness and nausea, weakness, loss of consciousness. (USCG, 1999)
CAMEO Chemicals
12.1.5 Fire Hazards
Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air.
Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor
explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or
explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)
U.S. Department of Transportation, Transport Canada, and Secretariat of Communications and Transport of Mexico, with collaboration from Argentina's Centro de Información Química para Emergencias. 2016 Emergency
Response Guidebook. https://www.phmsa.dot.gov/hazmat/outreach-training/erg (accessed April 26, 2016).
CAMEO Chemicals
Highly flammable. Vapour/air mixtures are explosive. Heating will cause rise in pressure with risk of bursting.
Flammable - 3rd degree
NJDOH RTK Hazardous Substance List
12.1.6 Fire Potential
A very dangerous fire hazard when exposed to heat or flame.

12.1.7 Skin, Eye, and Respiratory Irritations
Ethyl acetate vapor is irritating to the eyes and respiratory passages of man at concentrations above 400 ppm. ... Due to its irritating properties, employees will not voluntarily remain in such
high concentrations. ... This substance is a defatting agent, and prolonged exposure may cause irritation of the skin. Painful conjunctival irritation may occur from splashes in the eye.
Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing
Office, Jan. 1981., p. 1
Irritating to mucous surfaces, particularly the eyes, gums and respiratory passages ... . On repeated or prolonged exposures, it causes conjunctival irritation and corneal clouding.
12.1.8 EPA Hazardous Waste Number
U112; A toxic waste when a discarded commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or manufacturing chemical
intermediate.
F003; A hazardous waste from nonspecific sources when a spent solvent.
12.2 Safety and Hazard Properties
12.2.1 Flammable Limits
Lower 2.2%; upper 11.5% by volume in air

American Conference of Governmental Industrial Hygienists. Documentation of the TLVs and BEIs with Other World Wide Occupational Exposure Values. 7th Ed. CD-ROM Cincinnati, OH 45240-1634 2013., p. 1
Flammability
Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.
12.2.2 Lower Explosive Limit (LEL)
2 % (NTP, 1992)
CAMEO Chemicals
2%
2.0%
12.2.3 Upper Explosive Limit (UEL)
11.5 % (NTP, 1992)

CAMEO Chemicals
11.5%
12.2.4 Critical Temperature & Pressure
Critical temperature: 523.7 K; critical pressure: 3.88 MPa

12.2.5 Physical Dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible.
12.2.6 Explosive Limits and Potential

Explosive limits mol fraction in air: Upper 0.090, Lower 0.025

Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. V21 369 (1983)
Explosive limits , vol% in air: 2.0-12.8
12.2.7 OSHA Standards
Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 400 ppm (1400 mg/cu m).
29 CFR 1910.1000 (USDOL); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of June 11, 2014: https://www.ecfr.gov
12.2.8 NIOSH Recommendations
Recommended Exposure Limit: 10 Hour Time-Weighted Average: 400 ppm (1400 mg/cu m).
12.3 First Aid Measures
12.3.1 First Aid
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or
poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a
hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all
affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for
treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth,
throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever
possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO
NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not
convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is
convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE
VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
CAMEO Chemicals
(See procedures)
Eye:Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical
attention immediately.
Skin:Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and
flush the skin with water promptly. If irritation persists after washing, get medical attention.
Breathing:Respiratory support
Swallow:Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.
12.3.2 Inhalation First Aid
Fresh air, rest. Refer for medical attention.
12.3.3 Skin First Aid
Rinse contaminated clothes (fire hazard) with plenty of water. Remove contaminated clothes. Rinse skin with plenty of water or shower.
12.3.4 Eye First Aid
Rinse with plenty of water for several minutes (remove contact lenses if easily possible).
12.3.5 Ingestion First Aid
Rinse mouth. Seek medical attention if you feel unwell.
12.4 Fire Fighting
Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: CAUTION: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient.
SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam. Do not use dry chemical extinguishers to control fires involving nitromethane (UN1261) or nitroethane (UN2842). LARGE
FIRE: Water spray, fog or alcohol-resistant foam. Do not use straight streams. Move containers from fire area if you can do it without risk. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS:
Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case
of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is
impossible, withdraw from area and let fire burn. (ERG, 2016)
CAMEO Chemicals
Use alcohol-resistant foam, foam, powder, carbon dioxide, fine water spray. In case of fire: keep drums, etc., cool by spraying with water.
12.4.1 Fire Fighting Procedures
Cool exposed containers with water.

Use carbon dioxide, dry chemical, or alcohol foam.

Wear self contained breathing apparatus for fire fighting if necessary.

Sigma-Aldrich; Material Safety Data Sheet for Acetic Acid, Product Number: 320099, Version 5.4 (Revision Date 02/21/2014). Available from, as of June 25, 2014. https://www.sigmaaldrich.com/safety-center.html
12.4.2 Firefighting Hazards
Flashback along vapor trail may occur.

12.5 Accidental Release Measures
12.5.1 Isolation and Evacuation
Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions.
LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions;
also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)
CAMEO Chemicals
12.5.2 Spillage Disposal
Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the
substance. Do NOT wash away into sewer. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose
of according to local regulations.
12.5.3 Cleanup Methods
ACCIDENTAL RELEASE MEASURES. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas.;
Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.; Methods and materials for containment and cleaning up: Contain spillage, and
then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.
Sigma-Aldrich; Material Safety Data Sheet for Ethyl Acetate, Product Number: 319902, Version 4.9. (Revision Date 06/18/2014). Available from, as of June 25, 2014. https://www.sigmaaldrich.com/safety-center.html
1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quantities, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for
evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be collected and atomized in a suitable
combustion chamber. Ethyl acetate should not be allowed to enter a confined space, such as a sewer, because of the possibility of an explosion.
1. By absorbing it in vermiculite, dry sand, earth, or a similar material.

The following wastewater treatment technologies have been investigated for Ethyl acetate: Concentration process: Biological treatment.
USEPA; Management of Hazardous Waste Leachate, EPA Contract No.68-03-2766 p.E-33 (1982)
The following wastewater treatment technologies have been investigated for Ethyl acetate: Concentration process: Activated carbon.
USEPA; Management of Hazardous Waste Leachate, EPA Contract No.68-03-2766 p.E-133 (1982)
12.5.4 Disposal Methods
Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste numbers U112 and F003, must conform with USEPA regulations in storage,
transportation, treatment and disposal of waste.
40 CFR 240-280, 300-306, 702-799 (USEPA); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of August 3, 2014: https://www.ecfr.gov
SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition
product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater
treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker
exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in
accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.
Incineration: Burn waste material in an approved waste disposal incinerator.

United Nations. Treatment and Disposal Methods for Waste Chemicals (IRPTC File). Data Profile Series No. 5. Geneva, Switzerland: United Nations Environmental Programme, Dec. 1985., p. 72
1. By absorbing it in vermiculite, dry sand, earth, or a similar material. 2. By atomizing in a suitable combustion chamber.
For more Disposal Methods (Complete) data for ETHYL ACETATE (6 total), please visit the HSDB record page.
12.5.5 Preventive Measures
SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance,
but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there
may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not
be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
SRP: Contaminated protective clothing should be segregated in a manner such that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. The
completeness of the cleaning procedures should be considered before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken
home at the end of shift, but should remain at employee's place of work for cleaning.
Employees should wash immediately with soap when skin is wet or contaminated. Provide emergency showers and eyewash.
Pohanish, R.P. (ed). Sittig's Handbook of Toxic and Hazardous Chemical Carcinogens 5th Edition Volume 1: A-H,Volume 2: I-Z. William Andrew, Norwich, NY 2008, p. 1122
The worker should immediately wash the skin when it becomes contaminated.
For more Preventive Measures (Complete) data for ETHYL ACETATE (6 total), please visit the HSDB record page.
12.6 Handling and Storage
12.6.1 Nonfire Spill Response
Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when
handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined
areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking
tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)
CAMEO Chemicals
12.6.2 Safe Storage
Fireproof. Separated from strong oxidants, strong bases and strong acids.
12.6.3 Storage Conditions
Keep tightly closed in cool place.

During transport: stable during transport. Storage temperature: ambient. Venting: open (flame arrester) or pressure-vacuum.
... Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Sigma-Aldrich; Material Safety Data Sheet for Ethyl Acetate, Product Number: 319902, Version 4.9. (Revision Date 06/18/2014). Available from, as of June 25, 2014. https://www.sigmaaldrich.com/safety-center.html
On storage, it is slowly decomposed by water.

12.7 Exposure Control and Personal Protection
12.7.1 Recommended Exposure Limit (REL)
REL-TWA (Time Weighted Average)
400 ppm (1400 mg/m³)
TWA 400 ppm (1400 mg/m3)
12.7.2 Permissible Exposure Limit (PEL)
PEL-TWA (8-Hour Time Weighted Average)
400 ppm (1400 mg/m³)
TWA 400 ppm (1400 mg/m3)
12.7.3 Immediately Dangerous to Life or Health (IDLH)
2000 ppm Based on 10% of the lower explosive limit. (NIOSH, 2016)
National Institute of Occupational Safety and Health. NIOSH Pocket Guide to Chemical Hazards (full website version). https://www.cdc.gov/niosh/npg (accessed August 2016).
CAMEO Chemicals
2000 ppm (Based on 10% of the lower explosive limit for safety considerations even though the relevant toxicological data indicated that irreversible health effects or impairment of escape
existed only at higher concentrations.)
2000 ppm
2000 ppm [10%LEL]
See: 141786
12.7.4 Threshold Limit Values (TLV)
8 hr Time Weighted Avg (TWA): 400 ppm.

American Conference of Governmental Industrial Hygienists. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. ACGIH, Cincinnati, OH 2014, p. 29
Excursion Limit Recommendation: Excursions in worker exposure levels may exceed 3 times the TLV-TWA for no more than a total of 30 minutes during a work day, and under no circumstances
should they exceed 5 times the TLV-TWA, provided that the TLV-TWA is not exceeded.
American Conference of Governmental Industrial Hygienists. Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices. ACGIH, Cincinnati, OH 2014, p. 5
400 ppm as TWA.
750 mg/m3, 200 ppm; peak limitation category: I(2); pregnancy risk group: C.
TLV-TWA (Time Weighted Average)
400 ppm [1979]
12.7.5 Inhalation Risk
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C.
12.7.6 Effects of Short Term Exposure
The substance is mildly irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of
consciousness.
12.7.7 Effects of Long Term Exposure
The substance defats the skin, which may cause dryness or cracking.
12.7.8 Allowable Tolerances
Residues of ethyl acetate are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide
formulations applied to growing crops only. Use: solvent, cosolvent.
40 CFR 180.910 (USEPA); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of June 11, 2014: https://www.ecfr.gov
12.7.9 Personal Protective Equipment (PPE)
Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the
skin when it becomes contaminated. Remove: Work clothing that becomes wet should be immediately removed due to its flammability hazard(i.e. for liquids with flash point Change: No
recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)
National Institute of Occupational Safety and Health. NIOSH Pocket Guide to Chemical Hazards (full website version). https://www.cdc.gov/niosh/npg (accessed August 2016).
CAMEO Chemicals
Organic vapor canister or air mask; goggles or face shield.

Wear protective gloves and clothing to prevent any reasonable probability of skin contact..
Breakthrough times greater than one hour reported by (normally) two or more testers for butyl rubber (Butyl). Some data usually from immersion tests suggesting breakthrough times greater
than one hour are not likely for natural rubber (Nat Rub), polyethylene (PE) and polyvinyl alcohol (PVA). Breakthrough times less (usually significantly less) than one hour reported by (normally)
two or more testers for neoprene (Neop), nitrile rubber (nitrile), and polyvinyl chloride (PVC). No data for neoprene /styrene-butadiene rubber (Neop/ SBR), nitrile rubber/polyvinyl chloride
(Nitrile/PVC), chlorinated polyethylene (CPE), polyurethane (PU), styrene-butadiene rubber (SBR) and viton.
ACGIH; Guidelines Select of Chem Protect Clothing Volume #1 Field Guide p.44 (1983)
Wear appropriate personal protective clothing to prevent skin contact.

For more Personal Protective Equipment (PPE) (Complete) data for ETHYL ACETATE (9 total), please visit the HSDB record page.
(See protection codes)

Skin:Prevent skin contact - Wear appropriate personal protective clothing to prevent skin contact.
Eyes:Prevent eye contact - Wear appropriate eye protection to prevent eye contact.
Wash skin:When contaminated
Remove:When wet (flammable)
Change:No recommendation
12.7.10 Respirator Recommendations
NIOSH/OSHA
Up to 2000 ppm:
(APF = 25) Any supplied-air respirator operated in a continuous-flow mode
(APF = 25) Any powered, air-purifying respirator with organic vapor cartridge(s)
(APF = 50) Any chemical cartridge respirator with a full facepiece and organic vapor cartridge(s)
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained
positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister
Any appropriate escape-type, self-contained breathing apparatus

Important additional information about respirator selection
12.7.11 Fire Prevention
NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Use non-sparking handtools. Do NOT use compressed air for filling,
discharging, or handling.
12.7.12 Exposure Prevention
PREVENT GENERATION OF MISTS!
12.7.13 Inhalation Prevention
Use ventilation, local exhaust or breathing protection.
12.7.14 Skin Prevention
Protective gloves.
12.7.15 Eye Prevention
Wear safety spectacles or eye protection in combination with breathing protection.
12.7.16 Ingestion Prevention
Do not eat, drink, or smoke during work.
12.8 Stability and Reactivity
12.8.1 Air and Water Reactions
Highly flammable. Slightly soluble in water. This chemical is slowly hydrolyzed by moisture.
CAMEO Chemicals
12.8.2 Reactive Group
Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters
CAMEO Chemicals
12.8.3 Reactivity Alerts
Highly Flammable
Peroxidizable Compound
CAMEO Chemicals
12.8.1 CSL Reaction Information
CSL No CSL00036
Reactants/Reagents THIONYL CHLORIDE; ETHYL ACETATE; IRON
GHS Category Gas Under Pressure
Warning Message Galvanised drums burst when used for storing thionyl chloride in ethyl acetate
Source Reference Bretherick’s
CSL Status Approved
Modified Date 5/31/2018
Pistoia Alliance Chemical Safety Library
CSL No CSL00124
Reactants/Reagents PERACETIC ACID; ETHYL ACETATE
Reaction Class CSL00002 oxidation
GHS Category Corrosive,Explosive,Flammable,Oxidizer
Warning Message Peroxides in ethyl acetate
Source Reference C&EN
CSL Status Approved
DOI Link http://pubs.acs.org/cen/safety/20001218.html
Additional Info peroxides in various batches of ACS-grade ethyl acetate. The level of peroxide in ethyl acetate is not required by ACS.
Modified Date 5/31/2018
Pistoia Alliance Chemical Safety Library
12.8.4 Reactivity Profile
ETHYL ACETATE is also sensitive to heat. On prolonged storage, materials containing similar functional groups have formed explosive peroxides. This chemical may ignite or explode with
lithium aluminum hydride. It may also ignite with potassium tert-butoxide. It is incompatible with nitrates, strong alkalis and strong acids. It will attack some forms of plastics, rubber and
coatings. It is incompatible with oxidizers such as hydrogen peroxide, nitric acid, perchloric acid and chromium trioxide. Violent reactions occur with chlorosulfonic acid. (NTP, 1992). SOCl2
reacts with esters, such as ethyl acetate, forming toxic SO2 gas and water soluble/toxic acyl chlorides, catalyzed by Fe or Zn (Spagnuolo, C.J. et al. 1992. Chemical and Engineering News
70(22):2.).
CAMEO Chemicals
12.8.5 Hazardous Reactivities and Incompatibilities
... can react vigorously with oxidizing materials ... Potentially explosive reaction with lithium tetrahydroaluminate. Ignites on contact with potassium teri-butoxide. Violent reaction with
chlorosulfonic acid, (LiAIH2 + 2-chloromethyl furan), oleum.
Incompatible with strong acids; strong alkalies; nitrates, strong oxidizers; chlorosulfonic acid; lithium aluminium hydride ...
Nitrates, strong oxidizers, alkalis & acids.

12.9 Transport Information
12.9.1 DOT Emergency Guidelines
/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures
with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks).
Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or
explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
U.S. Department of Transportation. 2012 Emergency Response Guidebook. Washington, D.C. 2012
/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn
skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no
answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all
directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.
/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective
clothing will only provide limited protection.
For more DOT Emergency Guidelines (Complete) data for ETHYL ACETATE (8 total), please visit the HSDB record page.
12.9.2 DOT ID and Guide
1173 129
DOT Emergency Response Guidebook; The National Institute for Occupational Safety and Health (NIOSH)
12.9.3 Shipping Name/ Number DOT/UN/NA/IMO
UN 1173; Ethyl acetate
IMO 3; Ethyl acetate
12.9.4 Standard Transportation Number
49 091 60; Ethyl acetate
12.9.5 Shipment Methods and Regulations
No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly
classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./
49 CFR 171.2 (USDOT); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of June 5, 2014: https://www.ecfr.gov
The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a
manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.
International Air Transport Association. Dangerous Goods Regulations. 55th Edition. Montreal, Quebec Canada. 2014., p. 237
The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of
recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted
when attempting to locate the appropriate procedures to be used when shipping any substance or article.
International Maritime Organization. IMDG Code. International Maritime Dangerous Goods Code Volume 2 2012, p. 52
12.9.6 DOT Label
Flammable Liquid
CAMEO Chemicals
12.9.7 EC Classification
Symbol: F, Xi; R: 11-36-66-67; S: (2)-16-26-33
12.9.8 UN Classification
UN Hazard Class: 3; UN Pack Group: II
12.10 Regulatory Information
12.10.1 Atmospheric Standards
This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended
effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for
equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Ethyl acetate is produced, as an intermediate or final product, by process
units covered under this subpart.
12.10.2 CERCLA Reportable Quantities
Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount
equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40
CFR 302.4 (section IV. D.3.b).
12.10.3 RCRA Requirements
U112; As stipulated in 40 CFR 261.33, when ethyl acetate, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a
manufacturing chemical intermediate, becomes a waste, it must be managed according to Federal and/or State hazardous waste regulations. Also defined as a hazardous waste is any residue,
contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial
exclusion from hazardous waste regulations (40 CFR 261.5).
F003; When ethyl acetate is a spent non-halogenated solvent, it is classified as a hazardous waste from a nonspecific source (F003), as stated in 40 CFR 261.31, and must be managed according
to State and/or Federal hazardous waste regulations.
12.10.4 FIFRA Requirements
Residues of ethyl acetate are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide
formulations applied to growing crops only. Use: solvent, cosolvent.
As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their
continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and
determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996.
Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other
factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Ethyl acetate is found on List D.
Case No: 4005; Pesticide type: insecticide, herbicide, antimicrobial; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects,
or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): Ethyl acetate; AI Status: The active
ingredient is no longer contained in any registered pesticide products ... "cancelled."
United States Environmental Protection Agency/ Prevention, Pesticides and Toxic Substances; Status of Pesticides in Registration, Reregistration, and Special Review. (1998) EPA 738-R-98-002, p. 292
12.10.5 FDA Requirements
Certification of this color additive when used as a diluent (in inks for marking fruit & vegetables) is not necessary for the protection of the public health and therefore batches thereof are
exempt from the requirements of section 706(c) of the Federal Food, Drug, and Cosmetic Act. /Restrictions incl no residue./
21 CFR 73.1 (USFDA); U.S. National Archives and Records Administration's Electronic Code of Federal Regulations. Available from, as of June 11, 2014: https://www.ecfr.gov
Ethyl acetate ... may be safely used in food in accordance with the following conditions: (a) The additive meets the specifications of the Food Chemicals Codex ... (b) The additive is used in
accordance with current good manufacturing practice as a solvent in the decaffeination of coffee and tea.
Synthetic flavoring substances and adjuvants /for human consumption/ that are generally recognized as safe for their intended use, within the meaning of section 409 of the Act. Ethyl acetate
is included on this list.
Synthetic flavoring substances and adjuvants /for animal drugs, feeds, and related products/ that are generally recognized as safe for their intended use, within the meaning of section 409 of
the Act. Ethyl acetate is included on this list.
The feed additive ethyl alcohol containing ethyl acetate meets the requirement of 27 CFR 21.62, being not less than 92.5 percent ethyl alcohol, each 100 gallons having had added the
equivalent of 4.25 gallons of 100 percent ethyl acetate. It is used in accordance with good feeding practices in ruminant feed supplements as a source of added energy.
12.11 Other Safety Information
12.11.1 History and Incidents
The wreck of the MV Ariadne, a Panamanian flag container ship, is examined as a case study of a hazardous substance emergency response in a third world country. /The ship/, carrying a cargo
of heavy fuel oil, tetraethyl lead, xylene, toluene, methyl isobutyl ketone, butyl acetate, ethyl acetate, and acetone was grounded while departing the harbor of Mogadishu, Somalia. The
Somalian government requested a team of technical advisors to help respond appropriately to the emergency. The major issues addressed by the advisory team were the need for additional
salvage equipment and expertise, the danger of toxic fumes from the fire and explosions aboard the ship, the presence and possible release of tetraethyl lead, possible port blockage by the
wreck, recovery of the chemical drums, and the extent of environmental damage caused by the release of oil, pesticides, and tetraethyl lead into the harbor. ...
Heare SF et al; 1986 Hazard Matl Spill Conf p.12-18 (1986)
13 Toxicity
13.1 Toxicological Information
13.1.1 Toxicity Summary
IDENTIFICATION AND USE: Ethyl Acetate is a colorless liquid with a smell similar to glue or nail polish that is used as an industrial solvent. Ethyl Acetate is used as a solvent for chemical
reactions. Because of its odor it is often used in cosmetics and its smell is associated with nail polishes. Additionally, it is used in confectionery, perfumes, and fruits because it evaporates at a
fast rate, leaving but the scent of the perfume on the skin. Ethyl acetate is an effective poison for use in insect collector as its vapors are a respiratory tract irritant whose vapors can kill the
insect quickly without destroying it, leaving it intact for study. HUMAN EXPOSURE AND TOXICITY: Short-term exposure to high levels of ethyl acetate results first in irritation of the eyes, nose
and throat, followed by headache, nausea, vomiting, sleepiness, and unconsciousness. High concentrations can cause CNS depression and congestion of the liver and kidneys. Chronic
poisoning has been described as producing anemia, leucocytosis (transient increase in the white blood cell count), and cloudy swelling, and fatty degeneration. Runners were evaluated after
complaining of wheezing coughing, rhinitis, or shortness of breath after practicing in a facility under construction. Investigation revealed levels of ethyl acetate and toluene low enough to meet
federal guidelines but apparently sufficient to cause symptoms in the athletes. Its carcinogenic properties are not known. Workers who in earlier years had been exposed to ethyl acetate
concentrations of 300 mL/cu m and who were exposed at the time of the investigation to 16 mL/cu m were found to have normal sperm quality. ANIMAL STUDIES: In animals it has a narcotic
effect at concentrations of over 5000 ppm. Repeated exposures of rabbits to 4450 ppm for 1 hr daily for 40 days resulted in anemia with leukocytosis, and damage to liver and kidneys. Male
rats exposed to a high dose (3600 mg/kg/day) of ethyl acetate by gavage showed significant toxic effects, which resulted in depressed body and organ weights, and depressed food
consumption. Female rats exposed to the high dose showed slight but non-significant depression of above parameters compared with controls. Exposure of rats to 750 and 1500 ppm ethyl
acetate via inhalation for 6 hr per day, 5 days per week for 13 weeks, diminished behavioral responses to unexpected auditory stimuli during the exposure session and appeared to have an
acute sedative effect. There were no signs of acute intoxication 30 min after exposure sessions ended. Rats exposed to 750 and 1500 ppm had reduced body weight, body weight gain, feed
consumption, and feed efficiency, which fully or partially recovered within 4 weeks. Reductions in body weight gain and feed efficiency were observed in male rats exposed to 350 ppm. The
principal behavioral effect of subchronic exposure was reduced motor activity in the 1500 ppm females, an effect that was not present after the 4-week recovery period. All other functional
observation battery and motor activity parameters were unaffected, and no pathology was observed in nervous system tissues. In conclusion, there was no evidence that subchronic exposure
up to 1500 ppm ethyl acetate produced any enduring neurotoxic effects in rats. Ethyl acetate is strong inducer of aneuploidy in the yeast Saccaromyces cerevisiae, but was negative for
mutagenicity in Salmonella typhimurium assays. The solvent yielded negative result in the micronucleus assay in Chinese hamsters in vivo. In vivo hydrolysis of ethyl acetate to acetic acid and
ethanol occurred rapidly. ECOTOXICITY STUDIES: Exposure of the common indian catfish (Heteropneustes fossilus) to 170 ppm of ethyl acetate for 3, 6, 12, 48, and 96 hr induced marked
changes in carbohydrate metabolism. Hepatic glycogen levels declined significantly at 3, 48, and 96 hr, but there was no marked alteration in muscle glycogen content at any of the exposure
periods. Hyperglycemia occurred at all time intervals. Blood pyruvate levels were elevated at 3, 6, 48, and 96 hr. Hyperlacticemia resulted at 3 and 96 hr, but hypolacticemia occurred at 6 and
12 hr. Impairment of carbohydrate metabolism might be responsible for the toxic action of ethyl acetate.
13.1.2 NIOSH Toxicity Data
13.1.3 Evidence for Carcinogenicity
Not listed
13.1.4 Health Effects
Health Effect Code(s)
HE8 - Nervous System Disturbances---Narcosis

HE16 - Irritation-Eyes, Nose, Throat, Skin---Mild
HE20 - Generally Low Risk Health Effects---Odor
13.1.5 Exposure Routes
The substance can be absorbed into the body by inhalation of its vapour.
inhalation, ingestion, skin and/or eye contact
13.1.6 Symptoms
irritation eyes, skin, nose, throat; narcosis; dermatitis
13.1.7 Inhalation Symptoms
Sore throat. Cough. Headache. Drowsiness.
13.1.8 Skin Symptoms
Redness. Dry skin.
13.1.9 Eye Symptoms
Redness.
13.1.10 Target Organs
Eyes, skin, respiratory system
13.1.11 Acute Effects
ChemIDplus
13.1.12 Interactions
Study of 30 workers exposed chronically to 15-50 mg of ethyl acetate in addition to 20 to 80 mg of amyl acetate/L of air showed no ... abnormalities in cornea, merely hyperemia of bulbar
conjunctiva. ... Prolonged inhalation may be damaging to lung, liver, kidney, & heart. ... No effect on eyes ... known from systemic absorption.
Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986., p. 412
Ethyl acetate in combination with toluene appeared to produce a mixture of lower toxicity than that of either compound alone. Mixing of ethyl acetate with propylene oxide, propylene glycol,
or formalin appears to decr its LD50 value, but its toxicity increases in combination with morpholine, ethylene glycol, or ethyl alcohol.
In order to determine the lung disease potential of waterproofing sprays, several components of suspected sprays, as well as a commercial spray, were tested on CD-l-mice. Mice placed in
inhalation chambers were exposed to aerosols containing one or more of the suspected components, including n-heptane, ethyl-acetate, fluororesin, silicone, and a commercial spray. An
intermittent inhalation methods was used to prevent the solvents from causing anesthetic death. Mice were sacrificed 1 hour after the end of exposure. The lungs of both exposed and control
mice were isolated and examined microscopically for any changes. The amounts released of the were similar. Mice exposed to the commercial and fluororesin sprays were cyanotic and
depressed for 1 hour, while those exposed to the other sprays were cyanotic for only several minutes. In almost all mice exposed to the commercial spray, significant changes relative to the
controls included a thickened pulmonary alveolar septa, cellular infiltration, fused and hemorrhaged alveolar walls, and diminished alveoli. Fluororesin particles were found in the alveolar space.
Significantly more pronounced pathological changes were discovered in mice exposed to the fluororesin spray, relative to the commercial spray. In mice exposed to the silicone spray,
significant differences were observed in alveolar collapse and hemorrhage, compared to the controls. The lungs of mice exposed to the N-heptane, ethyl-acetate, and fluororesin free sprays
were similar to control lungs. In mice exposed to the silicon resin free spray, significant changes, relative to the commercial spray group, included alveolar collapse, hyperemia, hemorrhage and
increased thickness and cellular infiltration of the septum. /It was/ concluded that ethyl-acetate and n-heptane contained in waterproofing sprays do not cause pulmonary disorders. Instead,
fluororesin is implicated in respiratory disorders caused by such sprays.
Yamashita M, Tanaka J; J Toxicol, Clin Toxicol 33 (6): 631-7 (1995)
13.1.13 Antidote and Emergency Treatment
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-
mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient
forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical
attention. /Esters and related compounds/
Currance, P.L. Clements, B., Bronstein, A.C. (Eds).; Emergency Care For Hazardous Materials Exposure. 3rd revised edition, Elsevier Mosby, St. Louis, MO 2007, p. 253
Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilation if
necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye
contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5
mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Esters and related compounds/
Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress.
Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if
necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with
signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine
hydrochloride to assist eye irrigation ... . /Esters and related compounds/
13.1.14 Medical Surveillance
Consider the points of attack /eyes, skin, respiratory system/ in placement and periodic physical examinations. Evaluate for brain and nervous system damage.
13.1.15 Human Toxicity Excerpts
/HUMAN EXPOSURE STUDIES/ A variety of national occupational exposure limits for ethyl acetate exist based on different studies, mostly relying on subjective evaluations of ethyl acetate as an
irritant. Only one study also used physiological methods with inconsistent results in subjective and objective data. The present study was designed to investigate ethyl acetate on three different
dimensions: behavioral, physiological and psychological indicators of adverse chemosensory effects were investigated during acute exposures to different concentrations of ethyl acetate.
Twenty-four subjects were challenged with ethyl acetate in three exposure patterns (2 ppm, 400 ppm, 400 ppm including peaks of 800 ppm). While the odor intensity is rated "strong",
trigeminal perceptions were rated less than "moderate". The absence of substantial trigeminal ratings was supported by physiological data. There was neither an effect of concentration on
blinking frequency nor on nasal resistance which both are indicators of irritation. Furthermore, there are no effects of ethyl acetate concentration on behavioral measures indicating no olfactory
or trigeminally mediated disturbance of cognitive processing. In conclusion, the results of this multilevel approach revealed no adverse chemosensory effects at ethyl acetate concentrations as
recommended by the German MAK-value.
PMID:18812215
Kleinbeck S et al; Toxicol Lett. 182(1-3):102-9 (2008).
/SIGNS AND SYMPTOMS/ The data present does not indicate that ethyl acetate is acute/ly/ toxic. Eye, nose and throat irritation has been reported after human exposure... Neither skin irritation
nor sensitization has been reported after human exposure. In one old review there is a statement of sensitization, resulting in inflammation of the mucous membranes and in eczematous
eruptions of the skin which is reported to appear in rare cases. ...The data that supports the neurotoxicological properties of ethyl acetate are scarce and often documented lacking necessary
data...
Steering group for assessment of health effects of chemicals. Nord Vol:15 pp 235-51(1999).
/SIGNS AND SYMPTOMS/ Unacclimated subjects found the odor of ethyl acetate objectionably strong at 200 ppm, and mild eye, nose, and throat irritation was experienced at 400 ppm.
/SIGNS AND SYMPTOMS/ SYMPTOMATOLOGY (acute intoxication): 1. Early emotional lability: exhilaration, boastfulness, talkativeness, remorse, and belligerency. 2. Impaired motor
coordination: slowed reaction time, slurred speech, ataxia. 3. Sensory disturbances: diplopia, vertigo. 4. Flushing of face, rapid pulse, sweating. 5. Nausea and vomiting. Eventual incontinence of
urine and feces. 6. Drowsiness, stupor, and finally coma, with impaired or absent tendon reflexes. Convulsive episodes may indicate hypoglycemia. 7. Pupils dilated or normal. 8. Peripheral
vascular collapse (shock); hypotension, tachycardia, cold pale skin, hypothermia. 9. Slow stentorous respiration. 10. Death from respiratory or circulatory failure or from aspiration pneumonitis.
11. During convalescence: postalcoholic headache and gastritis; infections, alcoholic psychoses. /Ethyl alcohol/
Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-169-70
For more Human Toxicity Excerpts (Complete) data for ETHYL ACETATE (14 total), please visit the HSDB record page.
13.1.16 Non-Human Toxicity Excerpts
/LABORATORY ANIMALS: Acute Exposure/ ... Animals could withstand an ethyl acetate concn of 2000 ppm for 65, four-hr exposures without apparent ill effects, as measured by lack of change
in body wt & in red & white blood counts.
/LABORATORY ANIMALS: Acute Exposure/ Leucopenia without change in differential or red blood cell counts was observed in rats exposed for 4 hr to increasing air concentration of ... ethyl
acetate. ... This effect was abolished by adrenalectomy. This solvent caused leucopenia only when exposure reached the irritant level. It is discussed that stress associated with the irritative
effect of chemicals can confound specific hematological effects.
PMID:2362083
Brondeau MT et al; J Appl Toxicol 10 (2): 83-6 (1990)
/LABORATORY ANIMALS: Acute Exposure/ In order to determine the lung disease potential of waterproofing sprays, several components of suspected sprays, as well as a commercial spray,
were tested on CD-l-mice. Mice placed in inhalation chambers were exposed to aerosols containing one or more of the suspected components, including n-heptane, ethyl-acetate, fluororesin,
silicone, and a commercial spray. An intermittent inhalation methods was used to prevent the solvents from causing anesthetic death. Mice were sacrificed 1 hour after the end of exposure. The
lungs of both exposed and control mice were isolated and examined microscopically for any changes. The amounts released of the were similar. Mice exposed to the commercial and
fluororesin sprays were cyanotic and depressed for 1 hour, while those exposed to the other sprays were cyanotic for only several minutes. In almost all mice exposed to the commercial spray,
significant changes relative to the controls included a thickened pulmonary alveolar septa, cellular infiltration, fused and hemorrhaged alveolar walls, and diminished alveoli. Fluororesin
particles were found in the alveolar space. Significantly more pronounced pathological changes were discovered in mice exposed to the fluororesin spray, relative to the commercial spray. In
mice exposed to the silicone spray, significant differences were observed in alveolar collapse and hemorrhage, compared to the controls. The lungs of mice exposed to the N-heptane, ethyl-
acetate, and fluororesin free sprays were similar to control lungs. In mice exposed to the silicon resin free spray, significant changes, relative to the commercial spray group, included alveolar
collapse, hyperemia, hemorrhage and increased thickness and cellular infiltration of the septum. /It was/ concluded that ethyl-acetate and n-heptane contained in waterproofing sprays do not
cause pulmonary disorders. Instead, fluororesin is implicated in respiratory disorders caused by such sprays.
Yamashita M, Tanaka J; J Toxicol, Clin Toxicol 33 (6): 631-7 (1995)
/LABORATORY ANIMALS: Acute Exposure/ The acute neurobehavioral effects of three acetates (amyl, ethyl, and n-butyl acetate) were investigated after 20-min inhalation exposures in mice
using locomotor activity and a functional observational battery (FOB). Ethyl and n-butyl acetate produced significant decreases in locomotor activity at the highest concentrations examined,
while amyl acetate was without effect. Minimally effective concentrations for activity-decreasing effects were 2000 ppm for ethyl acetate and 8000 ppm for n-butyl acetate. The potency order
was similar in the FOB where ethyl acetate was more potent in disrupting the neurobehavioral measures. The FOB profile of effects for all three acetates included changes in posture, decreased
arousal, increased tonic/clonic movements, disturbances in gait, delayed righting reflexes, and increased sensorimotor reactivity. Furthermore, handling-induced convulsions were produced in
some mice acutely exposed to each of these acetates. Recovery from the acute effects of these acetates was rapid and began within minutes of removal from the exposure chamber. The
acetates produced a profile of neurobehavioral effects that were different from those reported for depressant solvents (i.e., toluene, 1,1,1-trichloroethane) that are subject to abuse. Evidence is
emerging for qualitative differences in the acute neurobehavioral effects of various volatile chemicals.
PMID:9038240
Bowen SE, Balster RL; Fundam and Appl Toxicol 35 (2): 189-96 (1997)
For more Non-Human Toxicity Excerpts (Complete) data for ETHYL ACETATE (16 total), please visit the HSDB record page.
13.1.17 Non-Human Toxicity Values
LD50 Rat oral 11.3 mL/kg

LD50 Rabbit oral 4.9 g/kg

Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-201
LC50 Mouse inhalation 1500 ppm/4hr

LC50 Rabbit inhalation 2500 ppm/4hr

For more Non-Human Toxicity Values (Complete) data for ETHYL ACETATE (6 total), please visit the HSDB record page.
13.1.18 Ecotoxicity Values
LC50; Species: Heteropneustes fossilis (Common Indian catfish); Conditions: /freshwater, static/; Concentration: 212.5 ppm for 96 hr
Gupta AB, Srivastava AK; Ecotoxicol Environ Saf 6 (2): 166-70 (1982)
EC50; Species: Chlorococcales (Green Algae Order); Conditions: freshwater, static; Concentration: 4300000 ug/L for 24 hr; Effect: physiology, assimilation efficiency /formulation/
Krebs F; Dtsch Gewaesserkd Mitt 35 (5-6): 161-170 (1991) as cited in the ECOTOX database. Available from, as of July 13, 2014
EC50; Species: Scenedesmus subspicatus (Green Algae) exponential growth phase; Conditions: freshwater, static, 24 °C, pH 8.0-9.3; Concentration: 3300000 ug/L for 48 hr; Effect: population,
decreased biomass /formulation/
Kuhn R, Pattard M; Water Res 24 (1): 31-38 (1990) as cited in the ECOTOX database. Available from, as of July 13, 2014
EC50; Species: Scenedesmus subspicatus (Green Algae) exponential growth phase; Conditions: freshwater, static, 24 °C, pH 8.0-9.3; Concentration: 5600000 ug/L for 48 hr; Effect: decreased
population, general population changes /formulation/
Kuhn R, Pattard M; Water Res 24 (1): 31-38 (1990) as cited in the ECOTOX database. Available from, as of July 13, 2014
For more Ecotoxicity Values (Complete) data for ETHYL ACETATE (13 total), please visit the HSDB record page.
13.1.19 Ecotoxicity Excerpts
/AQUATIC SPECIES/ Exposure of the fish /common Indian catfish, Heteropneustes fossilus/ to 170 ppm of ethyl acetate for 3, 6, 12, 48, and 96 hr induced marked changes in carbohydrate
metabolism. Hepatic glycogen levels declined significantly at 3, 48, and 96 hr, but there was no marked alteration in muscle glycogen content at any of the exposure periods. Hyperglycemia
occurred at all time intervals. Blood pyruvate levels were elevated at 3, 6, 48, and 96 hr. Hyperlacticemia resulted at 3 and 96 hr, but hypolacticemia occurred at 6 and 12 hr. Impairment of
carbohydrate metabolism might be responsible for the toxic action of ethyl acetate.
Gupta AB, Srivastava AK; Ecotoxicol Environ Saf 6 (2): 166-70 (1982)
13.1.20 Ongoing Test Status
The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies",
"Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in
preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from, as of June 12, 2014: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?
fuseaction=ntpsearch.searchresults&searchterm=141-78-6]
13.1.21 Populations at Special Risk
Employees /with chronic respiratory, skin, liver, or kidney disase may be/ at increased risk from ethyl acetate.
13.2 Ecological Information
13.2.1 US EPA Regional Screening Levels for Chemical Contaminants
Resident Soil (mg/kg) 6.20e+01
Industrial Soil (mg/kg) 2.60e+02
Resident Air (ug/m3) 7.30e+00
Industrial Air (ug/m3) 3.10e+01
Tapwater (ug/L) 1.40e+01
Risk-based SSL (mg/kg) 3.10e-03
Chronic Oral Reference Dose

9.00e-01
(mg/kg-day)
Chronic Inhalation
Reference Concentration 7.00e-02
(mg/m3)
Volatile Volatile
Fraction of Contaminant
Absorbed in Gastrointestinal 1
Tract
Soil Saturation
1.08e+04
Concentration (mg/kg)
EPA Regional Screening Levels for Chemical Contaminants at Superfund Sites
13.2.2 US EPA Regional Removal Management Levels for Chemical Contaminants

Resident Soil (mg/kg) 1.90e+03
Industrial Soil (mg/kg) 7.90e+03
Resident Air (ug/m3) 2.20e+02
Industrial Air (ug/m3) 9.20e+02
Tapwater (ug/L) 4.30e+02
Chronic Oral Reference Dose

9.00e-01
(mg/kg-day)
Chronic Inhalation
Reference Concentration 7.00e-02
(mg/m3)
Volatile Volatile
Fraction of Contaminant
Absorbed in Gastrointestinal 1
Tract
Soil Saturation
1.08e+04
Concentration (mg/kg)
EPA Regional Screening Levels for Chemical Contaminants at Superfund Sites
13.2.3 Environmental Fate/Exposure Summary
Ethyl acetate's production and use in artificial flavoring, as a solvent, in the manufacture of smokeless powder, artificial leather, photographic films and plates, artificial silk, perfumes and in
cleaning textiles may result in its release to the environment through various waste streams. Ethyl acetate is a natural product of fermentation. Natural sources of ethyl acetate include animal
waste, plant volatiles, and microbes. Ethyl acetate occurs naturally in yeast and sugarcane, where it is photosynthetically produced. It is also released by molds. If released to air, a vapor
pressure of 93.2 mm Hg at 25 °C indicates ethyl acetate will exist solely as a vapor in the atmosphere. Vapor-phase ethyl acetate will be degraded in the atmosphere by reaction with
photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 9 days. Ethyl acetate does not contain chromophores that absorb at wavelengths >290 nm
and, therefore, is not expected to be susceptible to direct photolysis by sunlight. If released to soil, ethyl acetate is expected to have very high mobility based upon an estimated Koc of 18.
Volatilization from moist soil surfaces is expected to be an important fate process based upon a Henry's Law constant of 1.34X10-4 atm-cu m/mole. Ethyl acetate may volatilize from dry soil
surfaces based upon its vapor pressure. Utilizing the Japanese MITI test, 95% of the Theoretical BOD was reached in 2 weeks indicating that biodegradation is an important environmental fate
process in soil and water. If released into water, ethyl acetate is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. Volatilization from water surfaces is
expected to be an important fate process based upon this compound's Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 9 hrs and 6 days,
respectively. An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. Ethyl acetate's hydrolysis half-life at 25 °C and pH 7 is 2 years, indicating that
hydrlosys is not an important environmental fate process. Occupational exposure to ethyl acetate may occur through inhalation and dermal contact with this compound at workplaces where
ethyl acetate is produced or used. Monitoring data indicate that the general population may be exposed to ethyl acetate via inhalation of ambient air, ingestion of food, and dermal contact
with this consumer products containing ethyl acetate. (SRC)
13.2.4 Natural Pollution Sources
Ethyl acetate is a natural product of fermentation(1,2). Natural sources of ethyl acetate include animal waste, plant volatiles, and microbes(1). Ethyl acetate occurs naturally in yeast and
sugarcane, where it is photosynthetically produced. It is also released by molds(3).
(1) Graedel TE; Chemical Compounds in the Atmosphere. NY,NY: Academic Press pp. 223-34 (1978) (2) Reed G; Kirk-Othmer Encycl Chem Tech; 3rd ed NY,NY: Wiley Interscience 24: 789 (1983) (3) Kelly P et al; Esters of
Mono- and Alkenyl Carboxylic Acids and Mono-Polyalcohols. Patty's Toxicology. 6th ed. (1999-2014). New York, NY: John Wiley & Sons, Inc. On-line posting date: 17 Aug 2012
13.2.5 Artificial Pollution Sources
Ethyl acetate's production and use as a pharmaceutic aid (flavor); in artificial fruit essences; as a solvent for nitrocellulose, varnishes, lacquers, and aeroplane dopes; manufacturing smokeless
powder, artificial leather, photographic films and plates, artificial silk, perfumes; cleaning textiles, etc(1) may result in its release to the environment through various waste streams(SRC).
(1) O'Neil MJ, ed; The Merck Index. 15th ed., Cambridge, UK: Royal Society of Chemistry, p. 695 (2013)
13.2.6 Environmental Fate
TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 18(SRC), determined from a log Kow of 0.73(2) and a regression-derived equation(3), indicates that ethyl
acetate is expected to have very high mobility in soil(SRC). Volatilization of ethyl acetate from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant
of 1.34X10-4 atm-cu m/mole(4). Ethyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 93.2 mm Hg at 25 °C(5). Utilizing the Japanese MITI test, 95%
of the Theoretical BOD was reached in 2 weeks(6) indicating that biodegradation is an important environmental fate process in soil(SRC).
(1) Swann RL et al; Res Rev 85: 17-28 (1983) (2) Hansch C et al; Exploring QSAR. Hydrophobic, Electronic, and Steric Constants. ACS Prof Ref Book. Heller SR, consult. ed., Washington, DC: Amer Chem Soc p. 9 (1995) (3) US
EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available from, as of Jun 25, 2014: https://www.epa.gov/oppt/exposure/pubs/episuitedl.htm (4) Butler JAV, Tamchandani CN; J Chem Soc: 952-5 (1935)
(5) Daubert TE, Danner RP; Physical and Thermodynamic Properties of Pure Chemicals Data Compilation. Washington, DC: Taylor and Francis, (1991) (6) NITE; Chemical Risk Information Platform (CHRIP). Biodegradation
and Bioconcentration. Tokyo, Japan: Natl Inst Tech Eval. Available from, as of Jun 26, 2014: https://www.safe.nite.go.jp/english/db.html
AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 18(SRC), determined from a log Kow of 0.73(2) and a regression-derived equation(3), indicates that ethyl acetate
is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon a Henry's Law constant of 1.34X10-4 atm-cu m/mole(5). Using
this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 9 hrs and 6 days, respectively(SRC). According to a classification scheme(6),
an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI
test, 95% of the Theoretical BOD was reached in 2 weeks(7) indicating that biodegradation is an important environmental fate process in water(SRC).
(1) Swann RL et al; Res Rev 85: 17-28 (1983) (2) Hansch C et al; Exploring QSAR. Hydrophobic, Electronic, and Steric Constants. ACS Prof Ref Book. Heller SR, consult. ed., Washington, DC: Amer Chem Soc p. 9 (1995) (3) US
EPA; Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available from, as of Jun 26, 2014: https://www.epa.gov/oppt/exposure/pubs/episuitedl.htm (4) Lyman WJ et al; Handbook of Chemical Property
Estimation Methods. Washington, DC: Amer Chem Soc pp. 15-1 to 15-29 (1990) (5) Butler JAV, Tamchandani CN; J Chem Soc: 952-5 (1935) (6) Franke C et al; Chemosphere 29: 1501-14 (1994) (7) NITE; Chemical Risk
Information Platform (CHRIP). Biodegradation and Bioconcentration. Tokyo, Japan: Natl Inst Tech Eval. Available from, as of Jun 26, 2014: https://www.safe.nite.go.jp/english/db.html
ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethyl acetate, which has a vapor pressure of 93.2 mm Hg at 25
°C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl
radicals(SRC); the half-life for this reaction in air is estimated to be 9 days(SRC), calculated from its rate constant of 1.6X10-12 cu cm/molecule-sec at 25 °C(3). Ethyl acetate does not contain
chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).
(1) Bidleman TF; Environ Sci Technol 22: 361-367 (1988) (2) Daubert TE, Danner RP; Physical and Thermodynamic Properties of Pure Chemicals Data Compilation. Washington, DC: Taylor and Francis, (1991) (3) Atkinson R;
J Phys Chem Ref Data Monograph No. 1 (1989) (4) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 8-12 (1990)
13.2.7 Environmental Biodegradation
AEROBIC: Ethyl acetate, present at 100 mg/L, reached 95% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). A review concluded that
ethyl acetate is easily removed by biological treatment(2). Reported 5 day BOD values using a sewage inoculum range from 36-68% of theoretical(3-6) with the value being somewhat reduced
in salt water(3). One investigator reported that ethyl acetate was completely degraded in 20 hr using activated sludge(7). In a bench-scale continuous-flow activated sludge reactor with an 8
hour retention time, 99.9% removal including 17% volatilization loss) was obtained, with 80% of the theoretical BOD(8). Ethyl acetate was 90% biooxidized in a 20-day BOD test using a filtered
raw sewage seed; it was biooxidized 77% in a 28-day OECD closed-bottle test(9). A screening procedure that was systematically applied to a large number of organic chemicals ranked ethyl
acetate as being completely biodegraded in a short time by general microorganisms(10). After a 5 hr lag, 43 to 53% of theoretical BOD was obtained in 50 to 70 hr(10). In screening tests, ethyl
acetate, present at a concentration of 5 ppm, reached 26.6 and 57.1% of its theoretical BOD in 5 days using the standard dilution method and seawater dilution method, respectively(11). 99.9%
removal of ethyl acetate was observed in a complete mix continuous-flow activated sludge system; 93% of this removal was attributed to biodegradation(12).
(1) NITE; Chemical Risk Information Platform (CHRIP). Biodegradation and Bioconcentration. Tokyo, Japan: Natl Inst Tech Eval. Available from, as of Jun 26, 2014: https://www.safe.nite.go.jp/english/db.html (2) Thom NS,
Agg AR; Proc Roy Soc London B 189: 347-57 (1975) (3) Price KS et al; J Water Pollut Control Fed 46: 63-77 (1974) (4) Ettinger MB; Ind Eng Chem 48: 256-9 (1956) (5) Young RHF et al; J Water Pollut Control Fed 40: 354-68
(1968) (6) Heukelekian H, Rand MC; J Water Pollut Control Assoc 29: 1040-53 (1955) (7) Slave T et al; Rev Chim 25: 666-70 (1974) (8) Stover EL, Kincannon DF; J Water Pollut Control Fed 55: 97-109 (1983) (9) Waggy GT et
al; Environ Toxicol Chem 13: 1277-80 (1994) (10) Urano K, Kato Z; J Haz Mat 13: 135-45, 147-59 (1986) (11) Takemoto S et al; Suishitsu Odaka Kenkyu 4: 80-90 (1981) (12) Kincannon DF et al; J Water Pollut Control Fed 55:
157-63 (1983)
ANAEROBIC: Ethyl acetate has been demonstrated to be amenable to anaerobic biodegradation(1). It was mineralized (>75% of theoretical methane production) in 10% sludge from a
secondary digester within 8 weeks(2). 96% utilization occurred in an anaerobic reactor with a 20 day retention time(3). Ethyl acetate, at a concentration of 1000 mg/L, was readily degraded in
batch reactors containing anaerobic solids from an industrial anaerobic digester with some exposure to ethyl acetate(4). 100% loss of ethyl acetate was observed in aquifer slurries amended
with sulfate and nitrate following 244 days and 85 days incubation, respectively(5). 94% of theoretical methane production was observed after incubation in sediment and groundwater
collected from the methanogenic portion of an anoxic aquifer polluted by municipal landfill leachate(6).
(1) Speece RE; Environ Sci Tech 17: 416A-27A (1983) (2) Shelton DR, Tiedje JM; Appl Environ Microbiol 47: 850-7 (1984) (3) Chou WL et al; Biotech Bioeng Symp 8: 391-414 (1979) (4) Schwartz LJ; Appl Biochem Biotehcnol
28/29: 297-305 (1991) (5) Mormile MR et al; Environ Sci Technol 28: 1727-32 (1994) (6) Sulfita JM, Mormile MR; Environ Sci Technol 27: 976-8 (1993)
13.2.8 Environmental Abiotic Degradation
The rate constant for the vapor-phase reaction of ethyl acetate with photochemically-produced hydroxyl radicals is 1.60X10-12 cu cm/molecule-sec at 25 °C(1). This corresponds to an
atmospheric half-life of about 9 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(2). A base-catalyzed second-order hydrolysis rate constant of 0.12 L/mole-
sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 1.8 years and 66 days at pH values of 7 and 8, respectively(3). The observed rate constant for
the vapor-phase reaction of ethyl acetate with nitrate radicals is 1.4X1017 cu cm/molecule-sec(3,4). This corresponds to an atmospheric half-life of about 16 years(SRC) at an average night-
time nitrate radical concentration of 2X10+8 molecules/cu cm (nitrate radicals are unstable in sunlight)(2). The rate constant for the reaction of ethyl acetate with hydroxyl radicals in aqueous
solution is 4.0X10+8 L/mol sec(5). This corresponds to a half-life of about 5.5 years(SRC) at an average aqueous hydroxyl radical concentration of 1X1017 mol/L(6). Simple esters are resistant to
hydrolysis; ethyl acetate's hydrolysis half-life at 25 °C and pH 7 is 2.0 years(7). Ethyl acetate does not contain chromophores that absorb at wavelengths >290 nm(8) and, therefore, is not
expected to be susceptible to direct photolysis by sunlight(SRC).
(1) Atkinson R; J Phys Chem Ref Data Monograph No. 1 (1989) (2) US EPA; Estimation Program Interface (EPI) Suite. Ver.4.1. Nov, 2012. Available from, as of Jun 25, 2014:
https://www.epa.gov/oppt/exposure/pubs/episuitedl.htm (3) Atkinson R; J Phys Chem Ref Data Monograph p. 213 (1994) (4) Gramatica P et al; Atmos Environ 37: 3115-3124 (2003) (5) Buxton GV et al; J Phys Chem Ref
Data 17: 5138-82 (1988) (6) Mill T et al; Science 207: 886-7 (1980) (7) Mabey WR et al; J Phys Chem Ref Data Vol 7, No. 2 p. 411 (1978) (8) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington,
DC: Amer Chem Soc pp. 8-12 (1990)
13.2.9 Environmental Bioconcentration
An estimated BCF of 3 was calculated for ethyl acetate(SRC), using a log Kow of 0.73(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the
potential for bioconcentration in aquatic organisms is low(SRC).
(1) Hansch C et al; Exploring QSAR. Hydrophobic, Electronic, and Steric Constants. ACS Prof Ref Book. Heller SR (consult ed) Washington,DC: Amer Chem Soc p. 9 (1995) (2) US EPA; Estimation Program Interface (EPI) Suite.
Ver. 4.1. Nov, 2012. Available from, as of Jun 25, 2014: https://www.epa.gov/oppt/exposure/pubs/episuitedl.htm (3) Franke C et al; Chemosphere 29: 1501-14 (1994)
13.2.10 Soil Adsorption/Mobility
The Koc of ethyl acetate is estimated as 18(SRC), using a log Kow of 0.73(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that
ethyl acetate is expected to have very high mobility in soil(SRC). A log Ki (snow surface/air (cu m/sq m)) of -3.69 has been reported for sorption to snow(4).
(1) Hansch C et al; Exploring QSAR. Hydrophobic, Electronic, and Steric Constants. ACS Prof Ref Book. Heller SR (consult ed) Washington,DC: Amer Chem Soc p. 9 (1995) (2) US EPA; Estimation Program Interface (EPI) Suite.
Ver. 4.1. Nov, 2012. Available from, as of Jun 25, 2014: https://www.epa.gov/oppt/exposure/pubs/episuitedl.htm (3) Swann RL et al; Res Rev 85: 23 (1983) (4) Roth CM et al; Environ Sci Technol 38: 4078-4084 (2004)
13.2.11 Volatilization from Water/Soil
The Henry's Law constant for ethyl acetate is 1.34X10-4 atm-cu m/mole(1). This Henry's Law constant indicates that ethyl acetate is expected to volatilize from water surfaces(2). Based on this
Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 9 hours(SRC). The volatilization half-life from a model
lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 6 days(SRC). Ethyl acetate's Henry's Law constant indicates that volatilization from moist soil surfaces may
occur(SRC). Ethyl acetate is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 93.2 mm Hg(3).
(1) Meylan WM, Howard PH; Environ Toxicol Chem 10: 1283-93 (1991) (2) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 15-1 to 15-29 (1990) (3) US EPA;
Estimation Program Interface (EPI) Suite. Ver. 4.1. Nov, 2012. Available from, as of Jun 25, 2014: https://www.epa.gov/oppt/exposure/pubs/episuitedl.htm (4) Daubert TE, Danner RP; Physical and Thermodynamic
Properties of Pure Chemicals Data Compilation. Washington, DC: Taylor and Francis, (1991)
13.2.12 Environmental Water Concentrations
GROUNDWATER: Ethyl acetate was not detected in an aquifer polluted by a paint factory even though ethyl acetate was stored in buried tanks that leaked(1).
(1) Botta D et al; Comm Eur Com Eur 8518 (Anal Org Micropollut Water): 261-75 (1984)
DRINKING WATER: Ethyl acetate was detected, not quantified in 3 New Orleans drinking water plants(1). It was detected in drinking water, no levels given(2). Ethyl acetate was identified in
commercially bottled Artesian water(3).
(1) Keith LH et al; pp. 329-73 in Identification and Analysis of Organic Pollutants in Water Keith LH ed Ann Arbor Press, Ann Arbor MI (1976) (2) Kool HJ et al; Crit Rev Environ Control 12: 307-57 (1982) (3) Dowty BJ et al;
Environ Sci Technol 9: 762-5 (1975)
SURFACE WATER: Of 14 heavily industrialized river basins in USA (204 sites), only 1 site (Delaware River Basin) tested positive for ethyl acetate, at 1 ppb(1). The concentration in the Hayashida
River in Tatsumo City, Japan (site of leather industry) was reported at 585 ppb(2). Ethyl acetate was identified in water samples from the brook, Rickenbach East, Switzerland, which receives
discharges from a paint factory(3).
(1) Ewing BB et al; Monitoring to Detect Previously Unrecognized Pollutants in Surface Waters p. 75 USEPA-560/6-77-015 (1977) (2) Yasuhara A et al; Environ Sci Technol 15: 570-3 (1981) (3) Juettner F; Wat Sci Tech 25:
155-64 (1992)
13.2.13 Effluent Concentrations
Effluent gas from the metal painting factory and from the lumber painting factory contained ethyl acetate(1). Ethyl acetate emission rate was determined to be 0.10 mg/km following analysis of
205 air samples from the Gubrist highway tunnel, Zurich Switzerland, sampled in 2004(2).
(1) Yasuhara A et al; Chemosphere 13 (3): 469-82 (1984) (2) Legreid G et al; Eviron Sci Technol 41: 7060-7066 (2007)
Ethyl acetate was detected, not quantified in oil refinery final effluent(1) and effluent from sewage treatment plants(2). Ethyl acetate has been detected in U.S. municipal landfill leachate at
concentrations ranging from 42 to 290 g/L(3). Ethyl acetate was identified, but not quantified, in hazardous waste samples from a Midwest remedial action site(4). Ethyl acetate was detected,
but not quantified, in a grab sample of oil refinery final effluent from a refinery in Lockport, IL(5). Ethyl acetate was identified as a volatile organic compound in a composite waste sample
obtained from a barge which dumped its waste on Feb 9, 1978 at the Puerto Rico dumpsite(6). Ethyl acetate was identified in flue gas from a waste incineration plant in Germany(7).
(1) Ellis DD et al; Arch Environ Contam Toxicol 11: 373-82 (1982) (2) Shackelford WM, Keith LH; Frequency of Organic Compounds Identified in Water USEPA-600/4-76-062 (1976) (3) Roy WR; Contam Groundwaters,
Adriano DC et al, eds., Sci Rev: Northwood, UK 411-46 (1994) (4) Puskar MA et al; Environ Sci Technol 21: 90-6 (1987) (5) Ellis DD et al; Arch Environ Contam Toxicol 11: 373-82 (1982) (6) Brooks JM et al; Wastes Ocean, Vol
1, Duedall, IW ed, New York,NY: Wiley pp. 171-98 (1983) (7) Jay K, Stieglitz L; Chemosphere 30: 1249-60 (1995)
13.2.14 Atmospheric Concentrations
URBAN/SUBURBAN: Ethyl acetate was detected, not quantified in Leningrad, USSR(1). Average concentrations of ethyl acetate in urban air samples collected from four different sites in
Stockholm ranged from 0.27 to 2.64 ppb; the average concentration at a site 12 km outside Stockholm was 0.23 ppb(2). It was identified in ambient air from Pasadena, TX, Houston, TX, and
Glendora, CA(3). Ethyl acetate was detected at an arithmetic mean of 2.6 ug/cu m using 37 outdoor samples from 27 sites in Melbourne, Australia, sampled in summer/early autumn(4).
(1) Ioffe BV et al; J Chromatogr 142: 787-95 (1977) (2) Jonsson AE et al; Environ Int 11: 383-92 (1985) (3) Pellizarri ED; Development of Analytical Techniques for Measuring Ambient Atmospheric Carcinogenic Vapors, EPA-
600/2-75-076 (1975) (4) Brown SK; Indoor Air 12: 55-63 (2002)
INDOOR: Ethyl acetate was detected in indoor air samples from Northern Italy at concentrations of 9 and 26 ug/cu m(1). Ethyl acetate was detected in the indoor air of 12 out of 12 Canadian
homes in Nov and Dec 1986 at concentrations ranging from 3 to 13 ug/cu m, average 8.9 ug/cu m; indoor air concentrations in 6 Canadian homes in Feb and March 1987 ranged from 7 to 494
ug/cu m, average 153 ug/cu m (outdoor air average concentration 10 ug/cu m)(2). Ethyl acetate was detected in indoor air of new and recently renovated buildings in Switzerland at a
maximum concentration of 1052 ug/cu m(3). It was detected in at least one indoor air sample from 17 locations from two Stockholm preschools(4). Ethyl acetate was detected in samples from
27 new and established buildings in Melbourne, Australia, sampled in summer/early autumn. The arithmetic mean concentrations were; 4.2 ug/cu m (22 non-complaint buildings, 61 samples)
and 3.3 ug/cu m (5 complaint buildings, 11 samples)(5). The mean concentration in indoor air of manufactured and site-built homes in eastern and southeastern US is <0.5 ppb; sampling was
conducted in fall of 1997 and spring of 1998(6).
(1) DeBortoli M et al; Environ Int 12: 343-50 (1986) (2) Chan CC et al; J Air Waste Manage Assoc 40: 6-27 (1990) (3) Rothweiler H et al; Atmos Environ 26A: 2219-25 (1992) (4) Noma E et al; Atmos Environ 22: 451-60 (1988)
(5) Brown SK; Indoor Air 12: 55-63 (2002) (6) Hodgson AT et al; Indoor Air 10: 178-92 (2000)
RURAL/REMOTE: Ethyl acetate was identified in air at a forest site in the Eggegebirge in North Rhine-Westfalia, West Germany(1).
(1) Helmig D et al; Chemosphere 19: 1399-1412 (1989)
SOURCE DOMINATED: Ethyl acetate was detected in ambient air surrounding Kin Buc waste disposal site (4 sites) 0, trace, 4.1, 230 ug/cu m(1). Ethyl acetate was detected in ambient air near a
furnace used for incinerating paint wastes at a concentration of 0.7 ppbv(2).
(1) Pellizarri ED; Environ Sci Technol 16: 781-5 (1982) (2) Kelly TJ et al; Environ Sci Technol 27: 1146-53 (1993)
13.2.15 Food Survey Values
Ethyl acetate forms from the reaction of acetyl coenzyme A with ethanol, and its formation depends greatly on temperature. Maximum formation occurs at 20-25 °C. Therefore, top fermented
beers contain higher amounts of this ester.
Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. V24: 789 (1984)
Ethyl acetate is found in USA lager beer, 25 to 50 ppm(1). It is a component of Orleans vinegar(2) and artificial grape flavoring(3). Ethyl acetate was identified as a volatile component of roasted
filberts(4), fried bacon(5), Beaufort cheese(6), blue cheese(7), Idaho Russet Burbank baked potatoes(8), and the edible Korean chamchwi plant(9). Korean salt-fermented anchovy, big-eyed
herring, hair tail viscera and shrimp pastes contained ethyl acetate at mean concentrations of 3490, 1660, 2340, and 3750 ng/g, respectively(10). Ethyl acetate was detected in beer at a
concentration of 8 ppm(11). Ethyl acetate was identified as a volatile compound in kiwi fruit, comprising 3.9, 4.7, and 1.6% of the components in mature, ripe, and very ripe fruit,
respectively(12). It was also identified as a volatile component of pineapple guava at a concentration of 0.11 ug/g(13). Fresh grapefruit juice contained 1.65 ppm ethyl acetate(14). Ethyl acetate
was identified in mature and overripe guava fruits at concentrations of 614.1 and 8884.2 ug/kg, respectively(15). It was identified as a volatile flavor component of the strawberry variety Sivetta
and in Golden Delicious apples(16).
(1) Reed G; Kirk-Othmer Encycl Chem Tech 3rd ed. NY,NY: Wiley Interscience 24: 789 (1983) (2) Webb AD; Kirk-Othmer Encycl Chem Tech 3rd ed. NY,NY: Wiley Interscience 23: 757 (1983) (3) Jones MB; Kirk-Othmer Encycl
Chem Tech 3rd ed. NY,NY: Wiley Interscience 4: 712 (1978) (4) Kinlin TE et al; J Agric Food Chem 20: 1021-8 (1972) (5) Ho CT et al; J Agric Food Chem 31: 336-42 (1983) (6) Dumont JP, Adda J; J Agric Food Chem 26: 364-7
(1978) (7) Day EA, Anderson DF; J Agric Food Chem 13: 2-4 (1965) (8) Coleman EC et al; J Agric Food Chem 29: 42-8 (1981) (9) Chung TY et al; J Agric Food Chem 41: 1693-7 (1993) (10) Cha YJ, Cadwallader KR; J Food Sci
60: 19-24 (1995) (11) Hashimoto H, Kuroiwa YJ; J Inst Brewing 72: 151-62 (1966) (12) Bartley JP, Schwede AM; J Agric Food Chem 37: 1023-5 (1989) (13) Binder RG, Flath RA; J Agric Food Chem 37: 734-6 (1989) (14)
Cadwallader KR, Xu Y; J Agric Food Chem 42: 782-4 (1994) (15) Chyau CC et al; J Agric Food Chem 40: 846-9 (1992) (16) Dirinck P et al; Analysis of Volatiles, Berlin,Germany: Walter Degruyter and Co 381-400 (1984)
Ethyl acetate was identified as a volatile component of duck meat, duck fat, Cantonese style roasted duck, and Cantonese style roasted duck gravy at concentrations of <0.05, 2.43, 23.94, and
<0.05 ppb wet weight, respectively(1). It was identified as a volatile compound in fried chicken flavor(2), nectarines(3), Concord grape essence(4), three Conn Creek wines(5), Sukiyaki(6),
bananas(7), and floured Chickpea seed(8). Ethyl acetate was detected in fresh hand-squeezed (mechanically) unpasteurized orange juice from five different cultivars and one hybrid at
concentrations of, ppm: 0.28 (0.15 to 0.25) in Valencia oranges; 0.17 to 0.23 (0.15) in Pineapple oranges; 0.12 to 0.13 in Hamlin oranges; 0.77 in Florida navel oranges; 0.17 in California navel
oranges; 0.28 in Pera oranges; and 0.12 (0.082) in Ambersweet oranges(9). Large amounts of ethyl acetate were detected in headspace from Bisbee Delicious apples at the earliest harvests(10).
(1) Wu CM, Liou SE; J Agric Food Chem 40: 838-41 (1992) (2) Tang J et al; J Agric Food Chem 31: 1287-92 (1983) (3) Takeoka GR et al; J Agric Food Chem 36: 553-60 (1988) (4) Stevens KL et al; J Food Sci 30: 1006-7 (1965)
(5) Shimoda M et al; J Agric Food Chem 41: 1664-66 (1993) (6) Shibamoto T et al; J Agric Food Chem 29: 57-63 (1981) (7) Macku C, Jennings WG; J Agric Food Chem 35: 845-8 (1987) (8) Rembold H et al; J Agric Food Chem
37: 659-62 (1989) (9) Moshonas MG, Shaw PE; J Agric Food Chem 42: 1525-8 (1994) (10) Mattheis JP et al; J Agric Food Chem 39: 1902-6 (1991)
Ethyl acetate was detected, not quantified as a flavor volatile of Korean red pine (Pinus densiflora) sprout tea and pine needle tea; needles were collected in May to June 1995(1). It is a volatile
constituent from the leaves of Callicarpa japonica Thunb. /Japanese beautyberry/, a member of the Verbenaceae family native to Korea, Japan, China and Taiwan(2).
(1) Kim KY, Chung HJ; J Agric Food Chem 48:1 269-72 (2000) (2) Kim YS, Shin DH; J Agric Food Chem 52: 781-787 (2004)
13.2.16 Plant Concentrations
Ethyl acetate presence in plants(1).
Genus species Common name Part Concn ppm
Telosma cordata Merrill flowers Flower 0-1600
Ananas comosus Pineapple Fruit 120
Pletranthus coleoides Shoot 0-12
Aralia cordata Udo Stem 3
Citrus sinensis Orange Fruit juice
Asimina triloba Pawpaw Fruit
Carthamus tinctorius Safflower Flower
Camellia sinensis Tea Leaf
Carica papaya Papaya Fruit
Cucumis melo subsp ssp melo var cantalupensis Cantaloupe Petiole
Malus domestica Apple Plant
Prunus persica Peach Fruit
Ribes nigrum Black currant Fruit
Rubus idaeus Raspberry Plant
Zea mays Corn Silk Stigma Style
Zingiber officinale Ginger Essential oil
(1) USDA; Dr. Duke's Phytochemical and Ethnobotanical Databases. Plants with a chosen chemical. Ethyl acetate. Washington, DC: US Dept Agric, Agric Res Service. Available from, as of Jun 25, 2014: https://www.ars-
grin.gov/duke/
Ethyl acetate was identified as a volatile component of kiwi fruit flowers(1). Volatile emissions from Scots pine were found to contain ethyl acetate(2).
(1) Tatsuka K et al; J Agric Food Chem 38: 2176-80 (1990) (2) Singh HB, Zimmerman PB; Adv Environ Sci Technol 24: 177-235 (1992)
13.2.17 Fish/Seafood Concentrations
Ethyl acetate was identified in a sample of mussel collected from the Oarai Coast in Ibaraki, Japan on July 31, 1985 at a concentration of 97.1 ug/g(1).
(1) Yashuara A, Morita M; Chemosphere 16: 2559-65 (1987)
13.2.18 Milk Concentrations
Mother's milk from 4 urban areas in the USA, 1 of 8 samples positive(1).

(1) Pellizarri ED et al; Environ Sci Technol 16: 781-5 (1982)
13.2.19 Other Environmental Concentrations
Nail polish remover, nail polish, base-coats and other manicuring products contains ethyl acetate(1). The concentration in nail polish may be 40 wt%(2). Ethyl acetate was identified in the head-
space of biodegradable and mixed household waste at concentrations ranging from 0.1 to 1 mg/cu m(3). It was also identified in liquid exudate from garden waste(4). Ethyl acetate has been
identified as a volatile compound in the head-space of kitchen waste and mold-infested fiber board, kitchen waste exudate, stored food exudate, and garden waste head-space(5). Mean
emission rates of ethyl acetate from particle board/carpet were 0.025 mg/sq m-hr(6). Fine particle and gaseous emission rates of 3.72, 10.63, 1.17, and 8.19 mg/kg for softwood in fireplace,
hardwood in fireplace, hardwood in wood stove, and synthetic log, respectively, were reported following analysis of residential wood combustion(7).
(1) Personal Care Products Council; CosmeticsINFO.org. Washington, DC. Available from, as of Jun 25, 2014: https://www.cosmeticsinfo.org (2) Wallace LA et al; Res Triangle Inst, Research Triangle Park, NC Report 1991,
USEPA/600/D91/074; (NTIS PB91182865) (1991) (3) Wilkins K; Chemosphere 29: 47-53 (1994) (4) Wilkins K, Larsen K; Chemosphere 32: 2049-55 (1996) (5) Wilkins CK, Larsen K; J High Resol Chromatogr 18: 373-7 (1995)
(6) Colombo A et al; Sci Total Environ 91: 237-49 (1990) (7) McDonald JD et al; Environ Sci Technol. 34: 2080-91 (2000)
Ethyl acetate emissions from whiskey vats averaged 0.593 g/cu m grain input(1). Ethyl acetate occurs in cigarette smoke(2).
(1) Carter RV, Linsky B; Atmos Environ 8: 57-62 (1974) (2) Rodgman A, Perfetti TA; The Chemical Components of Tobacco and Tobacco Smoke. Boca Raton, FL: CRC Press (2008)
Ethyl acetate was identified as a volatile organic compound present in 3 of 3 samples of poultry manure at concentrations of 10.8, 23.0, and 61.2 mg/kg(1). The compound was detected not
quantified as a volatile organic compound emitted from dairy silages and other feedstuffs analyzed at a commercial dairy (3,000 cows) in Yolo Valley Co, CA(2).
(1) Yashuara A; J Chromatogr 387: 371-8 (1987) (2) Malkina IL, et al; J Environ Qual 40: 28-36 (2011)
13.2.20 Probable Routes of Human Exposure
According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of ethyl acetate is
1000 or greater; the data may be greatly underestimated(1).
(1) US EPA; Inventory Update Reporting (IUR). Nonconfidential 2006 IUR Records by Chemical, including Manufacturing, Processing and Use Information. Washington, DC: U.S. Environmental Protection Agency. Available
from, as of Jun 25, 2014: https://cfpub.epa.gov/iursearch/index.cfm
NIOSH (NOES Survey 1981-1983) has statistically estimated that 504,448 workers (119,505 of these were female) were potentially exposed to ethyl acetate in the US(1). Occupational exposure
to ethyl acetate may occur through inhalation and dermal contact with this compound at workplaces where ethyl acetate is produced or used. Monitoring data indicate that the general
population may be exposed to ethyl acetate via inhalation of ambient air, ingestion of food, and dermal contact with this consumer products containing ethyl acetate(SRC).
(1) NIOSH; NOES. National Occupational Exposure Survey conducted from 1981-1983. Estimated numbers of employees potentially exposed to specific agents by 2-digit standard industrial classification (SIC). Available from,
as of Jun 25, 2014: https://www.cdc.gov/noes/
Occupational exposure to ethyl acetate during nail sculpturing was studied in 74 salons in south-east Norway. The mean ethyl acetate indoor air concentration in 66 of 74 salons was 0.02 ppm,
range of 0.01-1.19 ppm. Concentrations varied depending on the nail sculpturing method used: acrylic method, 0.09-3.22 ppm, 0.19 ppm mean; UV gel method, 0.01-0.41 ppm, 0.15 ppm
mean; and resin and acrylic powder, 0.24-0.91 ppm, 0.27 ppm mean(1). The average exposure of ethyl acetate was found to be 0.16 and 0.18 ppm for aircraft paint primer and surface spraying
workers at a fighter plane facility(2).
(1) Gjolstad M, et al; J Environ Monit 8: 537-542 (2006) (2) Uang S et al; Sci Total Environ 356: 38-44 (2006)
Ethyl acetate was identified (relative abundance) in Belgian industrial air samples collected were: printing pastes (66%) and paints (30%), in car repair shops (45%), and in various other
industries (57%)(1). Mean concentrations of ethyl acetate in air during parquet work in Finland were 119 ppm during installation with resin adhesives; 319 ppm during puttying; 72 ppm during
sanding after puttying; 413 ppm during undercoat varnishing (nitrocellulose); 64 ppm during ureaformaldehyde varnishing; and 1 ppm during work with waterbased varnishes(2). It was also
detected in air during the use of contact adhesives at mean concentrations of 14 ppm during repair of a textile carpet (dispersion and contact adhesives); 83 ppm during repair of a textile
carpet (contact adhesives only); 29 ppm during beading of textile carpets (contact adhesives only); and 71 ppm during repair of bathroom floor mats (dispersion and contact adhesives)(2). Ethyl
acetate was detected in 36% of all air samples, at a mean concentration of 11 ppm, collected from Finnish furniture factories from 1975 to 1984(3). Breathing zone samples collected during
spray painting contained ethyl acetate at a geometric mean concentration of 9.51 ppm(4). It was detected in the air of one auto paint shop at a concentration of 10.5 mg/cu m(5). Ethyl acetate
was identified in 12% of 275 products (including thinners, degreasers, paints, inks, and dome reagents) used in workplaces in various industries(6). Ethyl acetate was identified in the breathing
zone of shoe factory workers(7). Ethyl acetate was detected in the ambient air of shoe factory in Italy in Nov 1991 at median concentrations of 10 and 7 mg/cu m(8). It was detected in indoor
air collected in a machine shop and a new office area at concentrations of 1.4 and 21.8 ppbv, respectively(9).
(1) Veulemans H et al; Am Indust Hyg Assoc J 48: 671-7 (1987) (2) Riala REE, Riihimaki HA; Appl Occup Environ Hyg 6: 301-8 (1991) (3) Priha E; Ann Occup Hyg 30: 289-94 (1986) (4) Myer HE et al; Am Ind Hyg Assoc J 54:
663-70 (1993) (5) Medinilla J, Espigares M; Ann Occup Hyg 32: 509-13 (1988) (6) Lehman E et al; pp. 31-41 in Safety and Health ASP Org Sol Expos Finland April 1985, Riihimaki V, Ulfvarson U, eds., New York, NY: Alan R
Liss Inc (1986) (7) Ahonen I, Schimberg RW; Br J Ind Med 45: 133-6 (1988) (8) Mutti A et al; Int Arch Occup Environ Health 65: S171-6 (1993) (9) Kelly TJ et al; Environ Sci Technol 27: 1146-53 (1993)
Ethyl acetate was identified in 8 printer's inks at concentrations ranging from 0.1 to 13.7% (w/w)(1). Ethyl acetate comprised 2.0 and 3.7% by weight of total organic gas emissions from
industrial surface coatings and thinning solvent, respectively(2). Ethyl acetate was found in glue used in Italian shoe factories(3). Ethyl acetate is present in shoe and leather glue(4).
(1) Rastogi SC; Arch Environ Contam Toxicol 20: 543-7 (1991)(2) Harley RA et al; Environ Sci Technol 26: 2395-408 (1992) (3) Perbellini L et al; Med Lav 83: 115-19 (1992) (4) Kelly P et al; Esters of Mono and Alkenyl
Carboxylic Acids and MonoPolyalcohols. Patty's Toxicology. 6th ed. (1999-2014). New York, NY: John Wiley & Sons, Inc. Online posting date: 17 Aug 2012
13.2.21 Body Burden
Mother's milk from 4 urban areas in the USA, 1 of 8 samples tested positive for ethyl acetate(1). 7 out of 12 breath samples collected from nine volunteers in Bayonne and Elizabeth, NJ
between July and Dec 1980 contained ethyl acetate at unreported concentrations(2). Ethyl acetate was identified as a component in 13.7% of expired air samples from 54 volunteers in the
Chicago area at a geometric mean concentration of 0.447 ng/L(3). Ethyl acetate was detected in expired air samples from 5 of 8 male volunteers at levels ranging from 0.30 to 190.0 ug/hr(4).
Five out of 8 personal air samples collected from volunteers in Bayonne and Elizabeth, NJ between July and Dec 1980 contained ethyl acetate at unreported concentrations(5).
(1) Pellizzari ED et al; Environ Sci Technol 16: 781-5 (1982) (2) Wallace LA et al; Environ Res 35: 293-319 (1984) (3) Krotoszynski BK et al; J Anal Toxicol 3: 225-34 (1979) (4) Conkle JP et al; Arch Environ Health 30: 290-5
(1975) (5) Wallace LA et al; Environ Res 35: 293-319 (1984)
14 Associated Disorders and Diseases

Disease References
Autism PubMed: 15585776, 7687150, 20423563, 6150139, 3410814, 12205654, 24130822
PubMed: 15607313, 17668437, 10379660, 14569192, 17403619, 20300169, 22284503, 22061338, 19783829,
Perillyl alcohol administration for cancer treatment
19010317
Celiac disease PubMed: 3816078, 16425363, 10063930, 6182605, 6182788, 24657864, 21970810, 27452636
PubMed: 16440420, 11418788, 8723414, 19491857, 17269711, 23516449, 23867873, 24811995, 25598765,
Crohn's disease
26806034, 26848182, 27609529, 28842642
PubMed: 21059682, 1740537, 17314143, 17269711, 21761941, 23516449, 23867873, 24811995, 25598765,
Ulcerative colitis
26806034, 26848182, 27609529, 28842642
Pervasive developmental disorder not otherwise specified PubMed: 24130822
Nonalcoholic fatty liver disease PubMed: 23454028
15 Literature
15.1 NLM Curated PubMed Citations
PubChem
15.2 Springer Nature References
Springer Nature
15.3 Thieme References
Thieme Chemistry
15.4 Wiley References
Wiley
15.5 Depositor Provided PubMed Citations
PubChem
15.6 Metabolite References
15.7 Chemical Co-Occurrences in Literature
PubChem
15.8 Chemical-Gene Co-Occurrences in Literature
PubChem
15.9 Chemical-Disease Co-Occurrences in Literature
PubChem
16 Patents
16.1 Depositor-Supplied Patent Identifiers
PubChem
Link to all deposited patent identifiers
PubChem
16.2 WIPO PATENTSCOPE

Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=XEKOWRVHYACXOJ-UHFFFAOYSA-N
PATENTSCOPE (WIPO)
17 Biomolecular Interactions and Pathways

17.1 Protein Bound 3D Structures
RCSB Protein Data Bank (RCSB PDB)
View 7 proteins in NCBI Structure
PubChem
17.1.1 Ligands from Protein Bound 3D Structures

PDBe Ligand Code EEE
PDBe Structure Code 1A7Y
PDBe Conformer
Protein Data Bank in Europe (PDBe)
17.2 Chemical-Gene Interactions
17.2.1 CTD Chemical-Gene Interactions
Comparative Toxicogenomics Database (CTD)
18 Biological Test Results

18.1 BioAssay Results
PubChem
19 Taxonomy
The LOTUS Initiative for Open Natural Products Research: frozen dataset union wikidata (with metadata) | DOI:10.5281/zenodo.5794106
20 Classification
20.1 Ontologies
20.1.1 MeSH Tree
Medical Subject Headings (MeSH)
20.1.2 NCI Thesaurus Tree
NCI Thesaurus (NCIt)
20.1.3 ChEBI Ontology
ChEBI
20.1.4 ChemIDplus
ChemIDplus
20.1.5 CAMEO Chemicals
CAMEO Chemicals
20.1.6 ChEMBL Target Tree
ChEMBL
20.1.7 UN GHS Classification
UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
20.1.8 EPA CPDat Classification
EPA Chemical and Products Database (CPDat)
20.1.9 NORMAN Suspect List Exchange Classification
NORMAN Suspect List Exchange
20.1.10 EPA DSSTox Classification
EPA DSSTox
20.1.11 Consumer Product Information Database Classification
Consumer Product Information Database (CPID)
20.1.12 LOTUS Tree
21 Information Sources
FILTER BY SOURCE ALL SOURCES
1. CAMEO Chemicals
LICENSE
CAMEO Chemicals and all other CAMEO products are available at no charge to those organizations and individuals (recipients) responsible for the safe handling of chemicals. However, some of the chemical data itself is subject to the
copyright restrictions of the companies or organizations that provided the data.
https://cameochemicals.noaa.gov/help/reference/terms_and_conditions.htm?d_f=false
ETHYL ACETATE
https://cameochemicals.noaa.gov/chemical/665
CAMEO Chemical Reactivity Classification

https://cameochemicals.noaa.gov/browse/react
2. CAS Common Chemistry

LICENSE
The data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.
https://creativecommons.org/licenses/by-nc/4.0/
Ethyl acetate
https://commonchemistry.cas.org/detail?cas_rn=141-78-6
3. ChemIDplus
LICENSE
https://www.nlm.nih.gov/copyright.html
Ethyl acetate [NF]

https://chem.nlm.nih.gov/chemidplus/sid/0000141786
ChemIDplus Chemical Information Classification

https://chem.nlm.nih.gov/chemidplus/
4. DTP/NCI
LICENSE
Unless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.
https://www.cancer.gov/policies/copyright-reuse
ETHYL ACETATE
https://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=70930
5. EPA Chemicals under the TSCA

LICENSE
https://www.epa.gov/privacy/privacy-act-laws-policies-and-resources
Acetic acid ethyl ester

https://www.epa.gov/chemicals-under-tsca
6. EPA DSSTox
LICENSE
Ethyl acetate
https://comptox.epa.gov/dashboard/DTXSID1022001
CompTox Chemicals Dashboard Chemical Lists

https://comptox.epa.gov/dashboard/chemical-lists/
7. European Chemicals Agency (ECHA)

LICENSE
Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and
data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency,
http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions:
Links can only be made to webpages that provide a link to the Legal Notice page.
https://echa.europa.eu/web/guest/legal-notice
Ethyl acetate
https://echa.europa.eu/substance-information/-/substanceinfo/100.005.001
8. Hazardous Substances Data Bank (HSDB)

ETHYL ACETATE
https://pubchem.ncbi.nlm.nih.gov/source/hsdb/83
9. Human Metabolome Database (HMDB)

LICENSE
HMDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material
(HMDB) and the original publication (see the HMDB citing page). We ask that users who download significant portions of the database cite the HMDB paper in any resulting publications.
http://www.hmdb.ca/citing
Ethyl acetate
http://www.hmdb.ca/metabolites/HMDB0031217
10. ILO International Chemical Safety Cards (ICSC)

LICENSE
The reproduction of ILO material is generally authorized for non-commercial purposes and within established limits. For non-commercial purposes of reproduction of data, any required permission is hereby granted and no further
permission must be obtained from the ILO, but acknowledgement to the ILO as the original source must be made.
https://www.ilo.org/global/copyright/request-for-permission/lang--en/index.htm
ETHYL ACETATE
https://www.ilo.org/dyn/icsc/showcard.display?p_version=2&p_card_id=0367
11. Occupational Safety and Health Administration (OSHA)

LICENSE
Materials created by the federal government are generally part of the public domain and may be used, reproduced and distributed without permission. Therefore, content on this website which is in the public domain may be used without
the prior permission of the U.S. Department of Labor (DOL). Warning: Some content - including both images and text - may be the copyrighted property of others and used by the DOL under a license.
https://www.dol.gov/general/aboutdol/copyright
ETHYL ACETATE
https://www.osha.gov/chemicaldata/263
12. The National Institute for Occupational Safety and Health (NIOSH)
LICENSE
The information provided using CDC Web site is only intended to be general summary information to the public. It is not intended to take the place of either the written law or regulations.
https://www.cdc.gov/Other/disclaimer.html
Acetic acid, ethyl ester

https://www.cdc.gov/niosh-rtecs/AH52C768.html
Ethyl acetate
https://www.cdc.gov/niosh/npg/npgd0260.html
13. Wikipedia
ethyl acetate
https://en.wikipedia.org/wiki/Ethyl_acetate
14. DOT Emergency Response Guidebook

ethyl acetate
https://www.phmsa.dot.gov/hazmat/erg/emergency-response-guidebook-erg
15. NJDOH RTK Hazardous Substance List

ethyl acetate
http://nj.gov/health/eoh/rtkweb/documents/fs/0841.pdf
16. Joint FAO/WHO Expert Committee on Food Additives (JECFA)

LICENSE
Permission from WHO is not required for the use of WHO materials issued under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Intergovernmental Organization (CC BY-NC-SA 3.0 IGO) licence.
https://www.who.int/about/who-we-are/publishing-policies/copyright
Ethyl acetate
http://www.fao.org/food/food-safety-quality/scientific-advice/jecfa/jecfa-flav/details/en/c/312/
17. ChEBI
Ethyl acetate
http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:27750
ChEBI Ontology
http://www.ebi.ac.uk/chebi/userManualForward.do#ChEBI%20Ontology
18. LOTUS - the natural products occurrence database

LICENSE
The code for LOTUS is released under the GNU General Public License v3.0.
https://lotus.nprod.net/
Biological/Chemical Tree
https://lotus.naturalproducts.net/
19. Comparative Toxicogenomics Database (CTD)

LICENSE
It is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the MDI Biological Laboratory and NC State University.
http://ctdbase.org/about/legal.jsp
http://ctdbase.org/detail.go?type=chem&acc=C007650
20. Consumer Product Information Database (CPID)

LICENSE
Copyright (c) 2021 DeLima Associates. All rights reserved. Unless otherwise indicated, all materials from CPID are copyrighted by DeLima Associates. No part of these materials, either text or image may be used for any purpose other than
for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior
written permission.
https://www.whatsinproducts.com/contents/view/1/6
Ethyl acetate
https://www.whatsinproducts.com/chemicals/view/1/196/000141-78-6
Consumer Products Category Classification
https://www.whatsinproducts.com/
21. EPA Chemical and Products Database (CPDat)

LICENSE
https://comptox.epa.gov/dashboard/DTXSID1022001#exposure
EPA CPDat Classification

https://www.epa.gov/chemical-research/chemical-and-products-database-cpdat
22. EPA Regional Screening Levels for Chemical Contaminants at Superfund Sites
LICENSE
Ethyl Acetate
https://epa-prgs.ornl.gov/cgi-bin/chemicals/csl_search
Ethyl Acetate
https://epa-prgs.ornl.gov/cgi-bin/chemicals/csl_search?tool=rml
23. EU Food Improvement Agents

Ethyl acetate
https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32012R0872
24. NORMAN Suspect List Exchange

LICENSE
Data: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0
https://creativecommons.org/licenses/by/4.0/
NORMAN Suspect List Exchange Classification

https://www.norman-network.com/nds/SLE/
25. EU REGULATION (EC) No 1272/2008

ethyl acetate
https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A02008R1272-20211001
26. Hazardous Chemical Information System (HCIS), Safe Work Australia

Acetic acid, ethyl ester
http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=43
27. NITE-CMC
Ethyl acetate - FY2009
https://www.nite.go.jp/chem/english/ghs/09-mhlw-2008e.html
https://www.nite.go.jp/chem/english/ghs/06-imcg-0572e.html

https://www.nite.go.jp/chem/english/ghs/19-mhlw-2086e.html
28. FDA Center for Food Safety and Applied Nutrition (CFSAN)
LICENSE
Unless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need
to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.
https://www.fda.gov/about-fda/about-website/website-policies#linking
Ethyl acetate
https://www.fda.gov/food/food-additives-petitions/food-additive-status-list
ETHYL ACETATE
https://www.cfsanappsexternal.fda.gov/scripts/fdcc/index.cfm?set=IndirectAdditives&id=ETHYLACETATE
ETHYL ACETATE
https://www.cfsanappsexternal.fda.gov/scripts/fdcc/index.cfm?set=FoodSubstances&id=ETHYLACETATE
29. FDA/SPL Indexing Data

LICENSE
76845O8NMZ
https://www.fda.gov/ForIndustry/DataStandards/SubstanceRegistrationSystem-UniqueIngredientIdentifierUNII/
30. Flavor and Extract Manufacturers Association (FEMA)

ETHYL ACETATE
https://www.femaflavor.org/flavor-library/ethyl-acetate
31. NMRShiftDB
https://pubchem.ncbi.nlm.nih.gov/substance/587877
32. SpectraBase
Ethyl acetate
https://spectrabase.com/spectrum/LGhDMWfR1fU
Ethyl acetate
https://spectrabase.com/spectrum/1TpoPoZzJp1
ACETIC ACID, ETHYL ESTER

https://spectrabase.com/spectrum/8scqEz8QhPe
ACETIC ACID ETHYL ESTER

https://spectrabase.com/spectrum/CnNzjp4uE9M
ETHYL ACETATE (99.6%)

https://spectrabase.com/spectrum/KlJSfm5daGU
ETHYL ACETATE
https://spectrabase.com/spectrum/GnQ6pXlHAnf
ETHYL ACETATE
https://spectrabase.com/spectrum/Coh65keXHiP
Ethylacetate
https://spectrabase.com/spectrum/DsPItg2Cofw

https://spectrabase.com/spectrum/889nXofl7PY
Ethyl acetate
https://spectrabase.com/spectrum/KLdNWezb5Fs

https://spectrabase.com/spectrum/JstGIiy3IcK

https://spectrabase.com/spectrum/uX7uWxJIVS
ETHYLACETATE
https://spectrabase.com/spectrum/91g52qlVRwe
ETHYLACETATE
https://spectrabase.com/spectrum/2VWhhjwC1g8
Ethyl acetate
https://spectrabase.com/spectrum/JUypxzSNPss
Ethyl acetate
https://spectrabase.com/spectrum/98urvKhjWmo

https://spectrabase.com/spectrum/72ESB1gi6De

https://spectrabase.com/spectrum/L3v5AexfvYj
33. MassBank Europe

LICENSE
https://github.com/MassBank/MassBank-web/blob/master/LICENSE
ETHYL ACETATE
https://massbank.eu/MassBank/Result.jsp?inchikey=XEKOWRVHYACXOJ-UHFFFAOYSA-N
34. MassBank of North America (MoNA)

LICENSE
The content of the MoNA database is licensed under CC BY 4.0.
https://mona.fiehnlab.ucdavis.edu/documentation/license
ETHYL ACETATE
http://mona.fiehnlab.ucdavis.edu/spectra/browse?inchikey=XEKOWRVHYACXOJ-UHFFFAOYSA-N
35. NIST Mass Spectrometry Data Center

LICENSE
https://www.nist.gov/srd/public-law
Ethyl Acetate
http://www.nist.gov/srd/nist1a.cfm
36. National Drug Code (NDC) Directory

LICENSE
ETHYL ACETATE
https://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-directory
37. NIOSH Manual of Analytical Methods

LICENSE
The information provided using CDC Web site is only intended to be general summary information to the public. It is not intended to take the place of either the written law or regulations.
https://www.cdc.gov/Other/disclaimer.html
141-78-6
https://www.cdc.gov/niosh/docs/2003-154/pdfs/1457.pdf
141-78-6
https://www.cdc.gov/niosh/docs/2003-154/pdfs/2549.pdf
38. NLM RxNorm Terminology

LICENSE
The RxNorm Terminology is created by the National Library of Medicine (NLM) and is in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from NLM. Credit to
the U.S. National Library of Medicine as the source is appreciated but not required. The full RxNorm dataset requires a free license.
https://www.nlm.nih.gov/research/umls/rxnorm/docs/termsofservice.html
https://rxnav.nlm.nih.gov/id/rxnorm/1314355
39. Pistoia Alliance Chemical Safety Library

THIONYL CHLORIDE; ETHYL ACETATE; IRON
http://www.pistoiaalliance.org/projects/chemical-safety-library/
40. Protein Data Bank in Europe (PDBe)

http://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/EEE
41. RCSB Protein Data Bank (RCSB PDB)

LICENSE
Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of
that structural data.
https://www.rcsb.org/pages/policies
https://www.rcsb.org/
42. Rhea - Annotated Reactions Database

LICENSE
Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations,
provided you credit (cite) Rhea.
https://www.rhea-db.org/help/license-disclaimer
https://www.rhea-db.org/rhea?query=CHEBI:27750
43. Springer Nature

44. SpringerMaterials
ethyl ethanoate
https://materials.springer.com/substanceprofile/docs/smsid_oixuqcjqpdydgbjq
45. The Cambridge Structural Database

https://www.ccdc.cam.ac.uk/structures/Search?Ccdcid=844080
https://www.ccdc.cam.ac.uk/structures/Search?Ccdcid=904088
46. Thieme Chemistry

LICENSE
The Thieme Chemistry contribution within PubChem is provided under a CC-BY-NC-ND 4.0 license, unless otherwise stated.
https://creativecommons.org/licenses/by-nc-nd/4.0/
47. Wiley
https://pubchem.ncbi.nlm.nih.gov/substance/?source=wiley&sourceid=115238
48. PubChem
https://pubchem.ncbi.nlm.nih.gov
49. Medical Subject Headings (MeSH)

LICENSE
Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
https://www.nlm.nih.gov/copyright.html
ethyl acetate
https://www.ncbi.nlm.nih.gov/mesh/67007650
MeSH Tree
http://www.nlm.nih.gov/mesh/meshhome.html
50. UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS)

GHS Classification Tree
http://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
51. ChEMBL
LICENSE
Access to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License
(http://creativecommons.org/licenses/by-sa/3.0/).
http://www.ebi.ac.uk/Information/termsofuse.html
Target Tree
https://www.ebi.ac.uk/chembl/target/browser
52. NCI Thesaurus (NCIt)

LICENSE
Unless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.
https://www.cancer.gov/policies/copyright-reuse
NCI Thesaurus Tree

https://ncit.nci.nih.gov
53. PATENTSCOPE (WIPO)

SID 403031491
https://pubchem.ncbi.nlm.nih.gov/substance/403031491
54. NCBI
https://www.ncbi.nlm.nih.gov/projects/linkout

LCSS Ethyl Acetate - CH3COOC2H5 - PubChem

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Find Similar Structures

Laboratory Chemical Safety Summary (LCSS) Datasheet

Molecular Formula C4H8O2 or CH3COOC2H5

Molecular Weight 88.11

LOTUS - the natural products occurrence database

1.3 Crystal Structures

CCDC Number 844080

Crystal Structure Data DOI:10.5517/ccxbbdy

Crystal Structure Depiction

Associated Article DOI:10.1021/cg200547k

The Cambridge Structural Database

2 Names and Identifiers

2.1 Computed Descriptors

2.1.1 IUPAC Name

2.1.3 InChI Key

2.1.4 Canonical SMILES

2.2 Molecular Formula

CAMEO Chemicals; Wikipedia; PubChem

ILO International Chemical Safety Cards (ICSC)

2.3 Other Identifiers

2.3.2 European Community (EC) Number

European Chemicals Agency (ECHA)

2.3.3 ICSC Number

ILO International Chemical Safety Cards (ICSC)

2.3.4 NSC Number

2.3.5 RTECS Number

The National Institute for Occupational Safety and Health (NIOSH)

FDA/SPL Indexing Data

2.3.8 JECFA Number

Joint FAO/WHO Expert Committee on Food Additives (JECFA)

2.3.9 FEMA Number

2.3.10 DSSTox Substance ID

NLM RxNorm Terminology

2.4.1 MeSH Entry Terms

Medical Subject Headings (MeSH)

2.4.2 Depositor-Supplied Synonyms

ETHYL ACETATE Essigester Ethylazetat acetic-acid-ethylester DSSTox_GSID_22001 CAS-141-78-6 ethylactate

3 Chemical and Physical Properties

Property Name Property Value Reference

Molecular Weight 88.11 Computed by PubChem 2.1 (PubChem release 2021.05.07)

XLogP3 0.7 Computed by XLogP3 3.0 (PubChem release 2021.05.07)

Rotatable Bond Count 2 Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07)

Exact Mass 88.052429494 Computed by PubChem 2.1 (PubChem release 2021.05.07)

Monoisotopic Mass 88.052429494 Computed by PubChem 2.1 (PubChem release 2021.05.07)

Heavy Atom Count 6 Computed by PubChem

Formal Charge 0 Computed by PubChem

Complexity 49.5 Computed by Cactvs 3.4.8.18 (PubChem release 2021.05.07)

Isotope Atom Count 0 Computed by PubChem

Defined Atom Stereocenter Count 0 Computed by PubChem

Undefined Atom Stereocenter Count 0 Computed by PubChem

Defined Bond Stereocenter Count 0 Computed by PubChem

Undefined Bond Stereocenter Count 0 Computed by PubChem

Covalently-Bonded Unit Count 1 Computed by PubChem

Compound Is Canonicalized Yes Computed by PubChem (release 2021.05.07)

3.2 Experimental Properties

3.2.1 Physical Description

EPA Chemicals under the TSCA

Human Metabolome Database (HMDB)

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.

ILO International Chemical Safety Cards (ICSC)

Joint FAO/WHO Expert Committee on Food Additives (JECFA)