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Synthetic biologists have engineered bacteria to convert carbon waste into Counting
valuable chemicals. The carbon-negative approach could contribute to a net- Galaxies To
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Bacteria are known for breaking down lactose to make yogurt
A Potential
and sugar to make beer. Now researchers led by Northwestern Cure for
University and LanzaTech have harnessed bacteria to break Autism: New
down waste carbon dioxide (CO2) to make valuable industrial Research Finds
chemicals. That Gene
Therapy Could
In a new pilot study, the researchers selected, engineered, and Treat Pitt-
Hopkins
optimized a bacteria strain and then successfully demonstrated
Syndrome
its ability to convert CO2 into acetone and isopropanol (IPA).

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Not only does this new gas fermentation process remove JUNE 4, 2022

greenhouse gases from the atmosphere, but it also avoids using NASA’s
fossil fuels, which are typically needed to generate acetone and DAVINCI Space
IPA. After performing life-cycle analysis, the team found the Probe To
carbon-negative platform could reduce greenhouse gas
Plunge Through
Hellish
emissions by 160% as compared to conventional processes, if
Atmosphere of
widely adopted. Venus
The study will be published today (February 21, 2022) in the
journal Nature Biotechnology. JUNE 4, 2022

Volcanic
“The accelerating climate crisis, combined with rapid Activity
population growth, pose some of the most urgent challenges to Beneath the
humankind, all linked to the unabated release and Surface of
accumulation of CO2 across the entire biosphere,” said Mars: Magma
Makes
Northwestern’s Michael Jewett, co-senior author of the study.
Marsquakes
“By harnessing our capacity to partner with biology to make Rock Red
what is needed, where and when it is needed, on a sustainable Planet
and renewable basis, we can begin to take advantage of the
available CO2 to transform the bioeconomy.”
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Jewett is the Walter P. Murphy Professor of Chemical and
Biological Engineering at Northwestern’s McCormick School of JUNE 4, 2022
Engineering and director of the Center for Synthetic Biology.
New Evidence
He co-led the study with Michael Koepke and Ching Leang, for Alternate
both researchers at LanzaTech. Origins of
Alzheimer’s
Necessary industrial bulk and platform chemicals, acetone, and Disease
IPA are found nearly everywhere, with a combined global Plaques
market topping $10 billion. Widely used as a disinfectant and
antiseptic, IPA is the basis for one of the two World Health
Organization-recommended sanitizer formulas, which are
highly effective in killing the SARS-CoV-2 virus. And acetone is
a solvent for many plastics and synthetic fibers, thinning
polyester resin, cleaning tools, and nail polish remover.

While these chemicals are incredibly useful, they are generated

from fossil resources, leading to climate-warming CO2

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6/7/22, 2:32 PM Engineered Bacteria Convert Captured Carbon Dioxide Into Valuable Chemicals for Fuels, Fabric, and Cosmetics

emissions.

To manufacture these chemicals more sustainably, the

researchers developed a new gas fermentation process. They
started with Clostridium autoethanogenum, an anaerobic
bacterium engineered at LanzaTech. Then, the researchers used
synthetic biology tools to reprogram the bacterium to ferment
CO2 to make acetone and IPA.

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“These innovations, led by cell-free strategies that guided both

Astronomy
strain engineering and optimization of pathway enzymes, Astrophysics Behavioral
accelerated time to production by more than a year,” Jewett
Science Biochemistry Biotechnology
said.
Black Hole Brain Cancer Cell Biology

The Northwestern and LanzaTech teams believe the developed Climate Change Cosmology
strains and fermentation process will translate to industrial COVID-19 Disease DOE Ecology
scale. The approach also could potentially be applied to create Energy European Space Agency
streamlined processes for generating other valuable chemicals. Evolution Exoplanet Genetics
Geology Harvard-Smithsonian Center for
“This discovery is a major step forward in avoiding a climate
catastrophe,” said Jennifer Holmgren, LanzaTech CEO. “Today, Astrophysics Hubble Space
most of our commodity chemicals are derived exclusively from Telescope Infectious Diseases
new fossil resources such as oil, natural gas or coal. Acetone JPL Marine Biology Mars Materials
and IPA are two examples with a combined global market of $10 Science Max Planck Institute Medicine
billion. The acetone and IPA pathways developed will accelerate
MIT Nanotechnology
the development of other new products by closing the carbon
cycle for their use in multiple industries.” NASA NASA Goddard Space Flight
Center Neuroscience Oceanography
Reference: “Carbon-negative, scaled-up production of acetone
Paleontology Particle Physics
and isopropanol by gas fermentation” by Fungmin Eric Liew,
Robert Nogle, Tanus Abdalla, Blake J. Rasor, Christina Canter, Planetary Science
Rasmus O. Jensen, Lan Wang, Jonathan Strutz, Payal Chirania,
Sashini De Tissera, Alexander P. Mueller, Zhenhua Ruan, Allan
Popular Public Health
Gao, Loan Tran, Nancy L. Engle, Jason C. Bromley, James Quantum Physics Vaccine Virology Yale

Daniell, Robert Conrado, Timothy J. Tschaplinski, Richard J. University

Giannone, Robert L. Hettich, Ashty S. Karim, Séan D. Simpson,
Steven D. Brown, Ching Leang, Michael C. Jewett and Michael
Köpke, 21 February 2022, Nature Biotechnology.
DOI: 10.1038/s41587-021-01195-w

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Jewett is a member of the Chemistry of Life Processes Institute,
Simpson Querrey Institute for BioNanotechnology and the
Robert H. Lurie Comprehensive Cancer Center of Northwestern
University. report th

The study, “Carbon-negative, scaled-up production of acetone

and isopropanol by gas fermentation,” was supported by the
U.S. Department of Energy (DOE) Bioenergy Technologies
Office (award numbers DE-EE0007566 and CRADA/NFE-16-
06364), DOE Office of Science, Biological and Environmental
Research Division, Genomic Science Program (award numbers
DE-SC0018249 and FWP ERKP903), the David and Lucile
Packard Foundation and the Camille Dreyfus Teacher-Scholar
Program.

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3 COMMENTS

ON "ENGINEERED BACTERIA CONVERT CAPTURED CARBON DIOXIDE INTO VALUABLE

CHEMICALS FOR FUELS, FABRIC, AND COSMETICS"
https://scitechdaily.com/engineered-bacteria-convert-captured-carbon-dioxide-into-valuable-chemicals-for-fuels-fabric-and-cosmetics/ 6/9
6/7/22, 2:32 PM Engineered Bacteria Convert Captured Carbon Dioxide Into Valuable Chemicals for Fuels, Fabric, and Cosmetics

Ken Towe | February 21, 2022 at 6:08 pm | Reply

“This discovery is a major step forward in

avoiding a climate catastrophe,”
Unless this “technology” can operate without fossils
fuels for transportation of the people and materials
needed … and can be scaled up to sequester the billions
of tons of CO2 needed to affect the climate, it remains
another interesting academic exercise.

Dani Eder | February 22, 2022 at 6:05 am | Reply

Bacterial production of ethanol and diesel

fuel was attempted a few years ago, but the cost was
uncompetitive at $100/barrel equivalent. The inputs
were captured CO2 and sunlight. This new process will
also live or die based on the final product cost relative to
the fossil-based versions.

Steve Nordquist | February 23, 2022 at 12:49 am |

Reply

Open Access too! What besides CO2 they feed the

and how they make bactericide in gruntlement is left to
reading on a bigger screen. Can this be golden (carbon
negative downbore fermentation) mining?

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