Electrosynthesis of bi-metallic MOF based electrochemiluminescence

biosensor for dual-target determination of immunoassay

Muhammad Faizan1, Pravanjan Malla1, Chi-Hsien Liu1*
1
Department of Chemical and Material engineering, Chang Gung University, Taoyuan,
Taiwan

No. 259, Wenhua 1st Rd, Guishan District, Taoyuan City, 333

mfaizan.chemist@outlook.com

MOST ___ -___ - ____- ____

Graphic Abstract:

Abstract:
Nano scale and bio-based metal-organic frameworks (MOFs) are an important class of
porous materials potentially used in biomedical application. Herein, a novel citric acid
based electro magnetic (CA@Cu-Zn-MOFs) are electrosynthesized using a simple
electrochemical approach in which the citric acid MNP added in organic ligand: 1,2,4,5-
benzenetricarboxylic acid and Tetrabutylammonium tetrafluoroborate (TBATFB)
(Lestari, Arvinawati et al. 2017). The electrosynthesis of CA@Cu-Zn-MOF performed at
ambient temperature under voltage of 50V in the solvent mixture of ethanol: water
(50:50) having the current of 20mA at 30 minutes. Compared to conventional methods
for synthesis of MOFs, electrochemical methods provide several advantages such as
shorter synthesis times, controlling the thickness and morphology by altering applied
current or voltage, as well as mild synthesis conditions. The optimum condition was
determined based on the percent yield of the product which upon washing and drying at
100oC under the vaccum. After that the final material is modified with the luminol and
capture probe, target and detection probe tagged with the alexa flour and pacific blue and
put on the biosensor for detection purpose.

References
[1] Lestari W, Arvinawati M, Martien R, Kusumaningsih T. Green and facile synthesis of
MOF and nano MOF containing zinc(II) and benzen 1,3,5-tri carboxylate and its
study in ibuprofen slow-release. Material Chemistry and Physics 2018;204:141-146.

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References
[1] Van der Geer J, Hanraads JAJ, Lupton RA. The art of writing a scientific article. J Sci
Commun 2000;163:51–9.
[2] Mettam GR, Adams LB. How to prepare an electronic version of your article. In:
Jones BS, Smith RZ, editors. Introduction to the electronic age, New York: E-
Publishing Inc; 1999, p. 281–304.

Nano scale and bio-based metal-organic frameworks (MOFs) are an important class of
porous materials potentially used in biomedical application. Herein, a novel citric acid
based electro magnetic (CA@Cu-Zn-MOFs) are electrosynthesized using a simple
electrochemical approach in which the citric acid MNP added in organic ligand: 1,2,4,5-
benzenetricarboxylic acid and Tetrabutylammonium tetrafluoroborate (TBATFB). The
electrosynthesis of CA@Cu-Zn-MOF performed at ambient temperature under voltage of
50V in the solvent mixture of ethanol: water (50:50) having the current of 20mA at 30
minutes. Compared to conventional methods for synthesis of MOFs, electrochemical
methods provide several advantages such as shorter synthesis times, controlling the
thickness and morphology by altering applied current or voltage, as well as mild
synthesis conditions. The optimum condition was determined based on the percent yield
of the product which upon washing and drying at 100oC under the vaccum. After that the
final material is modified with the luminol and capture probe, target and detection probe
tagged with the alexa flour and pacific blue and put on the biosensor for detection
purpose.

Lestari, W., et al. (2017). "Green and facile synthesis of MOF and nano MOF containing
zinc(II) and benzen 1,3,5-tri carboxylate and its study in ibuprofen slow-release."
Materials Chemistry and Physics 204.