(19) PE AREA RAR HA fp (12) BAAS Al BIS * (10) FRBAAS CN 106008183 (43) e145 AL 2016. 10. 12 (21) RS 201610396 2070 213/002008.01) (22) 1% 2016.08.07 0076 215/30. 2008.01) 6078 57/00 2006.01) C71) ERA, TT Ps RE LA FIR Sd HMbh 322118 RTL AT ae eT ASE TH ATERSI3 (72) SARA ER SOT IES APR E WER NIT a skee (74) SAH BUNA ADL TBA BE (61) Int.c1 0070 45/48 2006 .01) 0076 49/80 2006.01) 6076 221/00(2006 .01) 6076 225/16 2006.01) HER RoE (54) SAAS SRBC HR BER BET OE AEP Te A A Hl a FE (67) ARBEIT — REE RS HR BT PbS il ATH» AE DA 2A AE De eA CE AMR AE eS EAT A Be Be WE S21 SRR 1 FR AE a 2-1 1 FAP FB de A BEARS AM AOA AT SR ARE OR EE HIRE AS LE EAE RL Fo SBA SiS EER FS Ba EBA EAL ITE Bk BI DA 5 LA Be A I FA Fh eM HT AS LTE BA TIMED T Aa FT RE AT = DR BA LEHI. CN 106008183CN 106008183 4 Rl BR BP Wk 1. FARR SRL ly RHA AS Hi» HORE» ARIE IL CER 5 TRA BEAT 98 BH WSL 1 EF. 2 ARAB AALBERS TR SHR BE PT] AS eH» RPMI ET. 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Coil TAT ACR TRAE EAN ERA ae Sci: [0009] J.Org.Chem 1947,12:506 Acta Chim Sci Hung 1958, 17:181 Tetrahedron Letters 2000, 41:953 foorel Tetrahedron Letters 1989, 30:329 Synthesis 1990:573 (ort) 38 RHINE FASS LP TM A ACURA PS BU Ps SR SRSA BDA) — AN SARE FAT AT BE PE TERRI oor2} Ey SL Re 2 Bn AA ek A EACN 106008183 4 hh A 2/11 Fk s cl “COOH * PCh > oT + Hypo, (a8) ° cS act AO 4 bo AHL i f - + AIC 6HO (=) roto L . aoe G) Br ~ © + HBr (R=B) S Soe ° ° 4 an NaOH, a = Cry cto A ee it eee 2 ery ~—_a, f fy, | (RY) SO NHCHs \ QF nts / \ /2 z g OH { \ sosta tes crx + peta (aH) 4 NHCH, | ~ HCH; \ f2 Coot] BAS Lae RAY AREY WLP EB eas Bee ASH "FRE 25 Tb Ayal 31 (12), 534-535, 2000 tootsMed.Chem 5221), 6768-6781, 2009 15 Forensic Science International 212 (1-3), 13-21, 2011 Analytical Chem. 85 (19), 9400-9408, 2013 [0016] wo2010121002A1 [0017] CNLO41192404 (loots) bk Ar neah PEE EMP BBE ASE ALSO Tb Pe AR ER EA BER FRIER: C0019] epi «ESS — A es BR SE PRI 0 A Ae DEA OY FF ESE RT PRU HE 7 (0020) SRY, BAe 1-95 I I Hl A ORT ANY D7 HE AE HO SCAR . 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BEA EAE AAT TF ANY SB AN AAR, EAE SEAT Bc ML PDT AMA, MOTTE ALAS AE A SBR, SEHR ALAR EI [0038] SEW 2: T DMF HY i as TAS 15.2-154 °C, CEI WEA OR JY Jes ROSE AG A BS A TER TF UPR 2 AHR SMP UA BiG LE SEPP Aare SR TE «SI TD HR HEEL TF BY ACS» WT PSA ALF» A Pa (8) AUR 20 (9) «BADE» UALR Ss a is» AIR TR DUEL 6 ° ° Z fo] aAYy SS NHCH; A sw [0039] « oa Oo OH CH. Ph. ery - a eek ¢ So Neches + 28.0 2 Maen, Ta Hae N_ Ne CH A Han NCH e Ph ) ‘pt HsC OH HC hn a [0040] tk Ar9(8) kA IL . C0041] He A (9) EAL ACE A BK AT RSE AED Zé Journal of Chromatographic Science ,1994,32:5524RiHi. (0042) EPIT AS , EL IDAHO 65 SR ET BE LAT] AS RE — 1 REP WSR TDI KE PAE TAC SERED» EAE» RACES PRTG RA BA RRA Coo4s] tx SL > RRC A fy RR SER RE PT] 62S 1 RAE 1 2 1 LPR AES A FT De HH AF LEB RD» AS BY BS ASAT TPR TE EI» BET RAT DL EE RAYA PU eA ER LET ER Cooaa] A AR HR| RINE HE ET — Ail AR LEA RB RORY Aa» LTA RL A de A hl MAAK FRR ATT MALE 5CN 106008183 A Cooas] — — RR AEN Da WR SMe fi) 16 2—SR- 1-2 PARES AUPE YS GURY Zs TER (0046) A AREY Ss HERP A OM lap A 2 I BR FR AP YN10 ) Ea BRIS Z AVA BEE M21 AEE LTE LNG), DES CB ROLLA R Uia: ° Oo AICI; af ay A MO ye [0047] oO +l a 2 2 &y (i) f cl 10) (6) (loo4e] 7 EARP 5E Rae He Ay Oi» ASTI Ce a Be ME A A IY, ABE BY WAR A ESI Ae iQ ML REBAR As RE RIS TT LEB 2 HA EAR RI eT E RE D 9 7 AE A BK TRA RAE BI95-98%6 5 HER THEM HEA Ai Sei Rh Pe AT BE IPL i. (0049) Bak TM Ae 7 SH ek A OT I, A L2H 1A AE PE FLAT ie PETE AR PE AAS HE AC BS AUF OS BR A SL PU EF FSR HEL Jk Sr LE) SP OBS AHR Fh a AR UA Be PERE TA Se A AT) BB GP Puli. 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(loos) fe ARISE BRE PE RAG IPA 2—SUAN BE SS SIU RH RR ET ~ 5) Aaa ab hi SR ACTA SSI a TRAE AR ACA 1 ~ 1) 0 TR Sa FEEL LAG AF) — PCG BARE AD PE JE RG IT Sa SRL, SEE SE AK AUC Ee CoosS] RFF BCE FTA 2—SR dC EA — BRIT SEL HG ZK TV BE B-5 7CN 106008183 4 hh A 6/1 ~ 10°C EAE HR I0~ 5 C 0 2-3 MI» 1E10~40°C ZI Fe ETE AE EN AY SQINLIT T AR L ~ SME 6 (0066) — fin Si (RAE HCH i) 82 Be E—1 EP hd 4S» Ts (007) LB EAA FR A WMH 2S 1 S81 PB Fe PP BE 2 FA BSE ARSE 1 CL Oo oO aa CHgNH2 Uy o0se) cl (2) l 2 NHCHs <6) wn [0059] (Ey — BRIN AT FE 9 RSE I» DSI Sa RTA» A LARLY EL RAGA AT RTI a Pe i EY I A 9 I SU (0060) Ea fea » EPR EAE ACA FE A RP FE ALE ak RE PEAT PEE 2 i FRI LE FE LAE AK AR AE BEAT 0 AS a EA FEB LEAS A 1 2-198 BL BRU AU EF PG AE AC AA, SL AE LETS SAP PP I I = A I HU deh A NN BERR rE A Wk AA a Et HH AT PR ee] Sy ET SUR MLAS RRR AR BIL» ERMA SE —1 ~~ (7) 0 Comet) Az WY BH Re Ra Yi EB 5 OUR AE HF RES} PFE WE CEA ETA EL PEER SREY BLAS 2 NRF AO) oo SS A Mi FET EECA (6) FRA SUR EEE: [0062] OC 1 an at S-NHCH3 (6) 1op) [0063] Zeb TTY SL IO IESE. 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PR STE BET EE AS EL A JPME Be Come) AEN a ee SP ACHE Aa DN a [0065] — AIRE AE RU UER YE 5 8) ERA FO FE AGREE AT HS A PR HD -20°C H-5 CZ ADGA Fa Bde CA» EL BEE a SF a PL WOH IE ZF Ab SER 2-8-1 RE A I [0066] FSB UERD FAIR Me SIE ATL SA B-20°C AF HE A CE ASA REL PRIA TRIER ANTES A B-20°C ZG PAT ERA 2S 1 PRAY PE » EE FG 7a AL FB 8CN 106008183 4 eA Vuk [0067] Ya Ae ArH TE MR) 2A 1 SB T U Sg HY 3895 26 BLE ILL FE SA A WGA IM 5 5 WL NAS 2 SR Wh FTP a Be (0068) fete Be nicseh BH B24 Wh ER AL 30.%6 AA AA TRB ALT PEE ‘AUDEN » PTA AS RTE Ac RPS Ss ao A 5 EA BE Ae NLT 4) ATA PS) 0 9 OH ae oe (4) (3) (0070) eH TAURI T AES Reb AEE a, MTEL TA RI PD (7) AOU US BEA BR RUA A (8) » SEE LE SF AL 7B LT By SEAN P EZ MRA TE, A-LINE MAE (9) 0 ° Ph Vs Hyc-N N+cH 0071] a - \=C 3 yc Ph <8) @ (0072) fe Ay Raa» FFA 2— Sa 1— 98 J Pa RA BEAR UG Ls 1 ~5 RR 2-SA-L-E— PAS FP CAPR AR EEL: (2. 5) » FR CTAL ny (2 PA (0073) Ay whl Re TASS GRE 5 AD RL FAC Ba PL ESR Fe 5 iT WA BRR ABARAT RN AR PG UCI RD LB «LG, Re BUA RU BL AA A ee ETH) — PR BE aE ARI» BRUT EAE FE AACR RR 5 FETA BRIG FB FET DR PERS «FE TR BE FE TA RRS FEAT PAU FETA ABS FEA RR FE Tk A Fk FEA SE, MRE — ARS Fo HE 5 HE A » PAPAS 2S — 1A HP 5 FP CO RARE (1B ~2.5)0 (0074) PE Ay aE» ER BQ MCT DA AE TS HG AE HB EAT 6 (ES HE ZN 9 ZEO-IMPa, (FEAT JZ MUAE-20°C BI 100°C-Z [AAT « COO7S] Ax ag ON Ga i AF MA, Bi WE HY 7293-97 M6 , 2—FH HE PEE 1 TEE BERTIE98-99% « (0076) Ae BY A WALA) 2— FP de 1 1 — PT VA OE FT Oe 5h tA A I LAE SE BE PETE AB TZ Jes a] BM Bs EO BI (0077) be SAS AOLMY ACA WEL 2h WI THAI HT A PREAVEDCAR FP DEA IEA Hs SOY AIAN FR PRS, AME 2-H CE 1 RIE PABACT) Ar RAC IEA LOR T LA (3) AIA) AMIS) (8) AAD 9) ELAS aL AE RGU AD BE A ASCE RY LAIR PGS SCRA SEL AS TIE FOR FS ZE ABTA PHAFLLES 3% AES FOR A Sb ak BEAR BA Fh Jak EHR HE A SP zk BE 9evrosoens BO Ae 5h Fe IAT SB 8 CL 2-1 2 TA (7) [0078] AACA ET — BB A RHR Dy PRD RNY Da TA 5 LAE 2 FH C1 HE 1 — PABA SP 5 I AE ARR ER ly RE ak IF 2— FA dei —1 9 J —1 Ps bE AS Fa PI FAL RR RRR Bly PRS FT] A 9 td Sg TS A PB 0 WR SE Tg i, J eg A Fe ° OH ° 5 a [00791 SA ge RG wy C NHMe CO NHMe. 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SFE AY BCMA 0% AUBI-20°C Ae Ai, BASIE N20 %6 FR AEE ETE WCLOTSEF 21. AE PAE 0. CONRAN) BIN TE YF Z NEF HA BOC BNE AIR FFE VLE 10°C BEAN AREF A E20 °C I BLINN» BR EE FPLC th EOS. 21.96 [0104] LOOSE ALAA INA BOLI » BSL 1EO—B CHF AS UNTKE h AR EL Sp 2-3. BP A AAC» BA SREB AAC JS UR SH RB SEZ RRP BF RE 1 HEIL PABA RARER (10) (41. 25 PAG Rae 3290.0% ) (01s) Se aR BB CCEA FAB HR BQ EB il 2-H Bec HE | ~ 3 EP) (0106) ERUPT 5 0. SFP AY A Aa 2 LHL MAE (GORE 10. TTAB) 9 RUBS CA SLAC FE A AAS C14. 258 50. AG FEE A » FH BG SPE BCR HE 20% ) 0 BE EFA] — ik HAE oc BH AP (31.658 0. 230B AR) BEERS IZ Ia HMA 8 i 2S | FESPA (38. 658.0. 23 AR DAY AE uCN 106008183 4 hh A 10/11 He TEMROORE AY « BE MENEZ Wa 1 PEF BI20-30 C , SEL FE A7ERLO .O5MPa» PRA IR SLLO/SY HPLC?” Sve 28/2298 . 74% 0 (oto7] Re mise te 2 AGIA SORE FE AA HEA EEL BSC Ze 47235 96 HR ARM HAZ p= 1-2, BEAL Feo VA SRF Ae BR PE 1 I OP AK Jak UK 0 FS SRE ZI TI EC AR TB AR DFR fie 1 8 SP a PRE (10) (42. 5» GAG MC E93.0% ) (lotos) Se ii BGC ZEZ. 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