Professional Documents
Culture Documents
Physio Test Do Not Answer
Physio Test Do Not Answer
drophobic te-
Hydrophilic
The phospholipids of the cell membrane:
A. are the most abundant of the three main types of cell membrane lipids:
e phospholipids, sphingolipids, and cholesterol
B. form the lipid bilayer, in which one end of each phospholipid molecule is soluble
-
only in fats e
C. form the lipid bilayer, in both ends of each phospholipid molecule are soluble only in
fats X
-
D. have a hydrophobic fatty acid portion
E. have a hydrophilic phosphate end -
F. form the lipid bilayer, in which both ends of each phospholipid molecule aresoluble
in water X is soluble
G. form the lipid bilayer, in which one end of each phospholipid molecule issoluble in
phosphate end
-
water -
H. are the most abundant of the three main types of cell membrane lipids:
phospholipids, glicolipids,
X and free fatty
Xacids X
X A. permeable to the usual water-soluble substances, such as ions, glucose, and oxygen I
-
*
I
- B. permeable to fat-soluble substances, such as oxygen, carbon dioxide, and alcohol, C2,02
Alconol
X
X C. impermeable to the usual water-soluble substances, such as glucose and oxygen
X D. permeable to fat-soluble substances, as oxygen, carbon dioxide, glucose, and alcohol
E. impermeable to the usual water-soluble substances, such as ions and oxygen
A. a concentration difference of the ions has developed in the same direction as the
electrical potential difference X
B. for univalent ions, EMF (electromotive force; voltage) between sides 1 and 2 of the
-
membrane is, in millivolts, ±61log C1/C2 at the given concentrations C1 and C2
-
C. the effect of concentration difference can never balance the effect of voltage
difference -
ID. at normal body temperature (37°C) and for univalent ions, EMF (electromotive force)
is ±0.61log
- C1/C2 (in milivolts) ⑲
E. the concentration difference and the electrical difference tend to move the ions in
the same direction T
F. a concentration difference of the ions has developed in the direction opposite to the
electrical potential difference -
G. the concentration difference tends to move the ions in one direction, while the
electrical difference tends to move them in the opposite direction
H. the effect of concentration difference balances the effect of voltage difference
I. for bivalent ions, EMF (current intensity) between sides 1 and 2 of the membrane is,
X
in millivolts, ±1.61log C1/C2 at the given concentrations C1 and C2
J. at normal body temperature (37°C) and for univalent ions, EMF (electromotive force)
is ±61log C1/C2 (in milivolts) ~Electrical difference move ions in 1 way
in the opposite
Conc difference moves ions
way
is of
300 milliosmoles
Osmotic pressure because
of particles
Not mass
per kg
4. Regarding the phenomenon of osmosis through a membrane:
A. the normal osmolality of the extracellular and intracellular fluids is about 300 milliosmole
milliosmoles per kilogram of water
-
per kg
⑰ B. the normal osmolality of the extracellular and intracellular fluids is about 0.03 E
= 2 osmoles D. the normal osmolality of the extracellular and intracellular fluids is about 30 I
now because milliosmoles per kilogram of water Nox
more
there's E. the osmotic pressure exerted by particles in a solution is determined by the mass of X
the particles.
F. the normal osmolality of the extracellular and intracellular fluids is about 300X
osmoles per kilogram of water -
-
G. osmosis is the net diffusion of water through a selectively permeable membrane
H. the osmotic pressure exerted by particles in a solution is determined by the number
e
-
of particles per unit volume of fluid, not by the mass of the particles.
X
I. if a solute dissociates into two ions, 1 gram molecular weight of the solute will
e
-
become 2 osmoles because the number of osmotically active particles is now twice
as great as is the case for the nondissociated solute
-
J. the normal osmolality of the extracellular and intracellular fluids is about 3 osmoles
per kilogram of water 10 from ATP 20: viaconc
=
:
2
0
ions bound to to the pump molecule e
7. By secondary active-> co-transport: _cori get transported on
-
A. the energy gradient of the sodium ion causes both the sodium ion and the other
when Nat
is
transported
out, substance to be transported together to the interior of the cell
conc
B. the diffusion energy of sodium cannot pull other substances along with it through
a
it creates
=> so
difference
wat diffuses passivethe cell membrane X
downhill (Downhill C. the carrier serves as an attachment point for the substance to be co-transported, but
other
& pulls
substances
along not for the sodium ion X
D. transport occurs downhill for the co-transported ion or neutral molecule X
with it.
suphiul
its passive
↳ E. the carrier serves as an attachment point for both the sodium ion and the substance
for the
substance to be co-transported -
F. the energy gradient of the sodium ion causes both the sodium ion and the other
substance to be transported together to the exterior of the cell A inside
G. the diffusion energy of sodium can pull other substances along with it through the
--
cell membrane-
the substance is
being
1. gradient,
but
this time,
cell.
-wed of out the
G. transport occurs uphill for the counter-transported ion or neutral molecule
H. transport occurs downhill for sodium
I. the diffusion energy of sodium can pull other substances through the cell membrane
in the opposite direction vs. sodium inflow
J. the energy released by the action of the sodium ion moving to the interior causes
the counter-transported substance to move to the exterior
9. Sodium ions drive secondary active transport, such as:
A. co-transport of amino acids in the same direction with sodium ions -
3
Nat /H
B. co-transport of glucose in the same direction with sodium ions
Nats?) C. counter-transport of glucose in the opposite direction vs. sodium ions
D. co-transport of calcium ions in the same direction with sodium ions X
counter t E. co-transport of hydrogen ions in the same direction with sodium ions
X
F. co-transport of calcium and hydrogen in the same direction with sodium ions X
G. counter-transport of hydrogen ions in the opposite direction vs. sodium ions -
Amino Acids
H. counter-transport of amino acids in the opposite direction vs. sodium ions X
+ Nat
= co-transport I. counter-transport of calcium ions in the opposite direction vs. sodium ions e
J. counter-transport of calcium and hydrogen ions in the opposite direction vs. sodium
ions
-
s
Later 10. When a membrane is permeable to several different ions, the diffusion potential that
develops depends on the: cone on inside & outside
3
3
- A. concentrations of the respective ions on the inside of the membrane but not on the
> Polarity of
outside X
the electrical B. polarity of the electrical charge of each ion
charge of equal C. concentrations of the respective ions on the inside of the membrane
D. permeability of the membrane to each ion but not on the concentrations of the
Permeable
each ion.
framethe respective ions on the inside of the membrane X
E. concentrations of the respective ions on the ouside of the membrane but not on the
> Cons ofrespective
on the inside X
ions
Outside F. concentrations of the respective ions on the inside and on the outside of the
Inside AND
of the membrane membrane
G. concentrations of the respective ions on the outside of the membrane but not on the
polarity of the electrical charge of each ion X
H. permeability of the membrane to each ion but not on the polarity of the electrical
charge of each ion
Greatly
I. permeability of the membrane to each ion
Membrane potential
11. The Goldman equation applied to cell membranes shows that: wat,
->
Y,
J. concentrations of the respective ions on the outside of the membrane
ci
A. if the membrane becomes more permeable to sodium ions, the membrane potential
becomes more dominated by the concentration gradient of sodium ions, and the
No
resulting potential will become closer to the Nernst potential for sodium
-
B. sodium, potassium, and chloride ions are the most important ions involved in the
-
ariezhens
will become even closer to the Nernst potential for potassium
12. The neuronal type of action potential has: ->
atthe
parables
A. a repolarization stage, when within a few 10,000ths of a second after the membrane
becomes highly permeable to sodium ions, the sodium channels close and the
potassium channels open to a greater degree than normal it-exterior.
- B. a repolarization stage, when the sodium channels open and the potassium channels
open to a greater degree than normal
C. a depolarization stage, when the membrane suddenly becomes permeable to sodium
ions, allowing tremendous numbers of positively charged sodium ions to diffuse to
the interior of the cell
D. a depolarization stage, with an “overshoot” beyond the zero level, in large nerve
fibers
E. a repolarization stage, when the potassium channels open to a greater degree than
normal and the rapid diffusion of potassium ions to theX interior of the cell re-
establishes the normal negative resting membrane potential
F. a depolarization stage, when the normal “polarized” state of −90 millivolts is
immediately neutralized by the inflowing positively charged sodium ions, with the
potential rising rapidly in the positive direction -
G. a depolarization stage, when the membrane suddenly becomes permeable to
potassium ions, allowing tremendous numbers of positively charged potassium ions
to diffuse to the interior of the cell X
H. a depolarization stage, when the normal “polarized” state of −20 millivolts is
neutralized by the inflowing positively charged potassium ions, with the potential
rising slowly in the positive direction X
I. a depolarization stage, with an “overshoot” beyond the zero level, in all the small
nerve fibers X
J. a repolarization stage, when the sodium channels close and the potassium channels
open to a greater degree than normal, and the rapid diffusion of potassium ions to
the exterior of the cell re-establishes the normal negative resting membrane
potential I near
outside
Activation gate
-
are
potential is −90 millivolts X depolariza
F. the activation gate closed in the normal resting membrane, when the membrane
potential is −90 millivolts
G. a sudden change in the activation gate to its open position, somewhere between
−50 and −30 millivolts, increasing the sodium permeability of the membrane as
much as 5- to 50-fold.
H. the inactivation gate near the inside of the channel
I. a sudden change in the activation gate to its open position, somewhere between
>−70 and −50 millivolts, increasing the sodium permeability of the membrane as
>
much as 500- to 5000-fold.
J. the activation gate near the outside of the channel
14. The voltage-gated sodium channel has its inactivation gate:
A. closed after the sodium channel has remained open for a few 10,000ths of a second
B. unable to reopen during repolarization until the membrane potential returns to or
near the original resting membrane potential level.
C. closed a few 10,000ths of a second after the activation gate opens
D. open a few 10ths of a second after the activation gate opens 4
E. in the open position while the activation gate is open in the normal resting
membrane, when the membrane potential is −90 millivolts
D F. in the open position while the activation gate is closed in the normal resting
-
D. may occur starting from the resting state, in which the conductance for potassium
10,000th ions is 50 to 100 times as great as the conductance for sodium ions
of a E. is based on rapid changes in sodium and potassium permeability -
di
secon F. has an onset that causes potassium channels to begin opening more slowly and 1-2
seconds after the sodium channels open
G. is based on rapid changes in sodium and potassium permeability E
H. may occur starting from the resting state, in which the conductance for sodium ions
is 50 to 100 times as great as the conductance for potassium ions
I. has an onset when the sodium channels instantaneously become inactivated and
allow up to a 5000-fold decrease in sodium conductance
when Nat channels Nat
are activated, - At rest, 1stis 50-100x >
x 5000 increase conductance.
J. has an onset that causes potassium channels to begin opening more slowly and a
fraction of a millisecond after the sodium channels open
16. During the neuronal type of action potential:
A. when the sodium channels begin to close and the potassium channels begin to open,
the membrane potential tends to quickly return to its baseline level
e
-
B. the ratio of sodium to potassium conductance increases more than 1000-fold in the
early portion of the action potential ** Nat after Action potential
C. the membrane potential tends to become positive at the action potential onset,
because far more sodium ions flow to the exterior of the cell than do potassium ions
to the interior X wat flows to interior
O
D. the return of the membrane potential to the negative state causes the potassium
channels to close back to their original status, but only after an additional millisecond
or more delay
- E. the repolarization is due to the shift in the conductance ratio, in favor of high
potassium conductance but low sodium conductance, allowing very rapid loss of
potassium ions to the exterior but virtually zero flow of sodium ions to the interior
F. when the sodium channels begin to open and the potassium channels begin to close,
the membrane potential tends to quickly return to its baseline level I
G. the repolarization is due to the shift in the conductance ratio, in favor of high sodium
conductance but low potassium conductance
H. the ratio of sodium to potassium conductance decreases more than 1000-fold in the
early portion of the action potential
I. the return of the membrane potential to the negative state causes the sodium
channels to close back to their original status, but only after an additional second or
more delay A
J. the membrane potential tends to become positive at the action potential onset,
because far more sodium ions flow to the interior of the cell than do potassium ions
-
necessary, and therefore requiring little energy expenditure for re-establishing the
sodium and potassium concentration differences across the membrane after a series
of nerve impulses
- F. the excellent insulation afforded by the myelin sheet and the 50-fold decrease in
membrane capacitance allow repolarization to occur with little transfer of ions
0 G. saltatory conduction means depolarization jumps long intervals along the axis of the
nerve fiber and this- increases the velocity of nerve transmission in myelinated fibers
as much as- 5- to 50-fold
0 H. almost no ions can flow through the thick myelin sheaths, but they can flow through
with ease at the nodes of Ranvier, so the action potentials are conducted from node
to node as saltatory conduction, that is electrical current flows through the
surrounding extracellular fluid outside the myelin sheath, as well as through the
cytoplasm inside the nerve fiber from node to node, exciting successive nodes one
after another
X I. saltatory conduction means depolarization jumps long intervals along the axis of the
nerve fiber and this increases the velocity of nerve transmission in myelinated fibers
as much as 5- e to 500-fold -
5 -
50x
J. saltatory conduction means depolarization jumps long intervals along the axis of the
nerve fiber and this increases the velocity of nerve transmission in myelinated fibers
as much as 5- to 10-fold X fibre 12500seconds
-
Large
=
18. The refractory period in nerve fibers shows that: 2500 imprises per second.
0 A. a new action potential cannot occur in a nerve fiber as long as the membrane is still
depolarized from the preceding action potential and this is because, shortly after the
action potential is initiated, the sodium channels become inactivated and no amount
gates
-
I
of excitatory signal applied to these channels at this point can open the inactivation
B. a new action potential cannot occur in a nerve fiber as long as the membrane is still
depolarized from the preceding action potential and this is because, shortly after the
A
action potential is initiated, the potassium channels become inactivated and no
-
amount of excitatory signal applied at this point can open their inactivation gates
C. a second action potential can be elicited in the absolute refractory period, but only
- with a stronger stimulus
D.Xa new action potential can be initiated in the absolute refractory period only when
the closed activation gates of the potasium channel can reopen
E. large myelinated nerve fibers can transmit a maximum of about 2500 impulses per
second
F. large myelinated nerve fibers can transmit a maximum of about 2500 impulses per
second
0 G. a new action potential can be initiated only when the inactivation gates of the
sodium channel can reopen and this is only when the membrane potential returns to
or near the original resting membrane potential level
0 H. a second action potential cannot be elicited in the absolute refractory period, even
with a strong stimulus takes for Depolarized membrane to
Time it
Refractory period
-
ROPAN.
REST-90mV. Nat AI channels will NOT
return to
stimulus size
Regardless of
I. the absolute refractory period is about 1/2500 second for large myelinated nerve
fibers
J. the absolute refractory period is about 1/2500 second for large myelinated nerve
fibers
19. The velocity of action potential conduction in nerve fibers:
A. cannot be less than 2.5 m/sec in small unmyelinated fibers
B. does not depend on wheter the fiber is myelinated or almost unmyelinated
C. depends on the fiber-- diameter
D. can be as little as 0.25 m/sec in small unmyelinated fibers
E. cannot be more than 10 m/sec in large myelinated fibers.
F. depends on wheter the fiber is of the myelinated type or of the unmyelinated type
G. varies from as little as 0.25 m/sec in large myelinated fibers to as great as 100 m/sec
in small unmyelinated fibers X
H. varies from as little as 0.25 m/sec in small unmyelinated fibers to as great as 100
m/sec in large myelinated fibers Ranges FROM
I. can be as great as 100 m/sec in large myelinated fibers.
Velocity Fibres
sermeab
I
C. can be only voltage-gated channels I
D. can be voltage-gated channels, which means opened or closed by gates that are
regulated by chemicals that bind to the channel proteins X
E. can be ligand-gated channels, which means opened or closed by gates that are
regulated by electrical signals -
F. can be ligand-gated channels -
G. are often selectively permeable to certain substances -
H. can be opened or closed by gates that are regulated by chemicals that bind to the
channel proteins (ligand-gated channels). -
I. can be opened or closed by gates that are regulated by electrical signals (voltage-
-
gated channels)
J. cannot be ligand-gated channels ligand.
b voltage
+
A
21. The opening and closing of the ion channel gates:
A. explains the initiation and termination of the action potential in nerve fibers by the
respective changes in the voltage-gated channels involved -
DKt gates are the
B. is controlled in two principal ways: voltage gating and chemical (ligand) gating on
inside
C. explains how the potassium gates on the intracellular ends of the volage-gated
- -
potassium channels open when the inner side of the cell membrane becomes
-
positively charged
-
(ligand) gating -
-
I. explains how the gates on the intracellular ends of the volage-gated potassium
channels open when the outer side of the cell membrane becomes positively
charged
>
-
-
interior
chemical
- water-soule
G. such as peptide hormones -
the fiber
myofibril I
W -
all
B. the light bands contain only myosin filaments and are isotropic to polarized light
I
C. the large projections from the sides of the myosin filaments are called cross-bridges
-
15003000
myosi Actin D. each muscle fiber contains several hundred to several thousand myofibrils and each
myofibril is composed of about 1500 adjacent myosin filaments and 3000 actin
-
filaments
E. in most skeletal muscles, each fiber extends the entire length of the muscle
F. each muscle fiber contains several hundred to several thousand myofibrils and each
Fiber myofibril is composed of about 1500 adjacent actin filaments and 3000 myosin
same as filaments X
length -
G. skeletal muscles are composed of numerous fibers ranging from 10 to 80
musch micrometers in diameter 1
X
H. each fiber is usually innervated by many nerve endings, located near the middle of
=T all the fiber
I. skeletal muscles are composed of numerous fibers ranging from 10 to 80
micrometers in length
-
J. the sarcolemma is the cell membrane and consists of a true cell membrane called the
-
plasma membrane -
27. The following statements about physiologic anatomy of skeletal muscle are true:
Actin
X A. the ends of the myosin filaments are attached to a so-called Z disc
IBand
=
Altin Only
B. the titin molecule has a molecular weight of about 3 kDa and sustains the myosin
and actin filaments in place
=150 TROPIC
C. the dark bands contain myosin filaments, as well as the ends of the actin filaments .
where they overlap the myosin, and are called XI bands because they are anisotropic
A band =
A bands
tends of to polarized light -
Myosin D. portion of the myofibril that lies betweenX three successive Z discs is called a
Actin
sarcomere 2 2 disks
ANISOTROPI
=
E. the portion of the myofibril that lies between two successive Z discs is called a
sarcomere
Ends of
Actin is
0 F. the light bands contain only actin filaments and are called I bands because they are
isotropic to polarized light
attached G. the ends of the actin filaments are attached to a so-called Z disc
H. the Z disc passes crosswise across the myofibril and also crosswise from myofibril to
to
0 myofibril, attaching the myofibrils to one another all the way across the muscle fiber
z-disk
Activ
Ibat:
0 I.the dark bands contain myosin filaments, as well as the ends of the actin filaments
where they overlap the myosin, and are called A bands because they are anisotropic
to polarized light
J. the light bands contain only actin filaments and are called I bands because they are
anisotropic to polarized light X
28. The following statements about physiologic anatomy of skeletal muscle are true:
A. when the muscle fiber is contracted, the length of the sarcomere is about 2
completely1 X
X micrometers and the actin filaments partially overlap the myosin filaments
B. the entire muscle fiber has light and dark bands, as do the individual myofibrils and
these bands give skeletal muscle their smooth appearance stricted appearance
-
x
C. each myofibril is composed of about 1500 adjacent myosin filaments and 3000 actin
filaments, which are very small polymerized protein molecules that are responsible
for the actual muscle contraction intracellular fluid.
x
D. the spaces between the myofibrils are filled with extracellular fluid called sarcoplasm,
containing large quantities of potassium, magnesium, and phosphate, plus multiple
protein enzymes X
E. into sarcoplasm are also present tremendous numbers of mitochondria that lie
parallel to the myofibrils that supply the contracting myofibrils with large amounts of
*
energy in the form of adenosine diphosphate ATP Tri-phosphate
-
F. the Z disc is composed of filamentous proteins different from the actin and myosin
filaments
0 G. into sarcoplasm are also present tremendous numbers of mitochondria that lie
parallel to the myofibrils that supply the contracting myofibrils with large amounts of
energy in the form of adenosine triphosphate
0 H. the spaces between the myofibrils are filled with- intracellular fluid called sarcoplasm,
containing large quantities of potassium, magnesium, and phosphate, plus multiple
protein enzymes
-
I. when the muscle fiber is contracted, the length of the sarcomere is about 2
micrometers and theE actin filaments completely overlap the myosin filaments
- J. the entire muscle fiber has light and dark bands, as do the individual myofibrils and
these bands give skeletal muscle their striated appearance
29. The following statements about physiologic anatomy of skeletal muscle areE
-
false:
A. the light bands contain only actin filaments and are called I bands because they are
isotropic to polarized light -
0 B. the dark bands contain myosin filaments, as well as the ends of the actin filaments
X
where they overlap the myosin, and are called I bands because they are anisotropic
to polarized light A
C. the sarcolemma is the cell membrane and consists of a true cell membrane called the
plasma membrane ~
D. the spaces between the myofibrils are filled with intracellular fluid called sarcoplasm,
containing large quantities of potassium, magnesium, and phosphate, plus multiple
protein enzymes ~
E. the portion of the myofibril that lies between two successive Z discs is called a
sarcomere -
x 1
0 F. each fiber is usually innervated by many nerve endings, located near the middle of
the fiber
0G. each muscle fiber contains several hundred to several thousand myofibrils and each
myofibril is composed of about 1500 adjacent actin filaments and 3000 myosin
filaments myosin
x Actin= x2 3000=
⑧
X
H. the spaces between the myofibrils are filled with extracellular fluid called sarcoplasm,
intracellular
containing large quantities of potassium, magnesium, and phosphate, plus multiple
protein enzymes
0 I. the light bands contain only actin filaments and are called I bands because they are
isotropic anisotropic to polarized lightX
J. skeletal muscles are composed of numerous fibers ranging fromme 10 to 80
micrometers in diameter
30. The following statements about physiologic anatomy of skeletal muscle areE false:
A. the Z disc passes crosswise across the myofibril and also crosswise from myofibril to
v
myofibril, attaching the myofibrils to one another all the way across the muscle fiber
0 B. the titin molecule has a molecular weight of about 3 kDa and sustains the myosin
and actin filaments in place =Actin x wrong
0 C. the light bands contain only myosin filaments and are isotropic to polarized light X
D. the Z disc is composed of filamentous proteins different from the actin and myosin
filaments v
E. the dark bands contain myosin filaments, as well as the ends of the actin filaments
where they overlap the myosin, and are called A bands because they are anisotropic
~
to polarized light
F. when the muscle fiber is contracted, the length of the sarcomere is about 2 ~small esti
micrometers and the actin filaments completely overlap the myosin filaments
·
A Proj
0
small
G. the large projections from the sides of the myosin filaments are called cross-bridges ans
-
-
H. each fiber is usually innervated by only one nerve ending, located near the middle of
the fiber -
O I. into sarcoplasm are also present tremendous numbers of mitochondria that lie
parallel to the myofibrils that supply the contracting myofibrils with large amounts of
Trix
energy in the form of adenosine diphosphate -
0 J. when the muscle fiber is contracted, the length of the sarcomere is about 2
-> completely
micrometers and the actin filaments partially overlap the myosin filaments
31. The following statements about general mechanism of muscle contraction are true:
A. the action potential depolarizes the muscle membrane and the electricity also flows
through the center of the muscle fiber where it causes the sarcoplasmic reticulum to
X X Large
release small quantities of calcium ions that have been stored within this reticulum
B. the calcium ions pumped back into the sarcoplasmic reticulum initiate attractive
other -for
forces between the actin and myosin filaments, causing them to slide alongside each
X new action potential
C. at each ending, the nerve secretes a small amount of the neurotransmitter substance
acetylcholine which acts on a local area of the muscle fiber membrane to open
not
multiple “acetylcholine-voltage gated” channels through protein molecules floating
in the membrane voltage gated
D. the calcium ions are released from the sarcoplasmic reticulum by a Ca++ membrane
pump, and they remain stored in the sarcoplasm until a new muscle action potential
comes along pumped back in
0 E. the action potential depolarizes the muscle membrane and the electricity also flows
through the center of the muscle fiber where it causes the sarcoplasmic reticulum to
-
release large quantities of calcium ions that have been stored within this reticulum
Q3) Action
↓
Potential
Acetylcholine
↓
Acetylcholine-gated channels
↓
watdiffuse
*
into cell causes an
Action Potential & depolarizing the membrane
↓
cat
#
is released by sacroplasmic
↓ reticulum
cat
*
causes myosin & Actin to Slide
across each other (contract (
↓
After cat is pumped back into
Sacroplasmic reticulum
by catmembrane
pumps
↓
catremains stored in reticulum &
waits for a new action potential
0F. the calcium ions released from the sarcoplasmic reticulum initiate attractive forces
between the actin and myosin filaments, causing them to slide alongside each other
⑧G. at each ending, the nerve secretes a small amount of the neurotransmitter substance
acetylcholine which acts on a local area of the muscle fiber membrane to open
multiple “acetylcholine- gated” channels through protein molecules floating in the
membrane X ligandgated
H. opening of the acetylcholine-voltage gated channels allows large quantities of
sodium ions to diffuse to the interior of the muscle fiber membrane initiating thus an
action potential at the membrane
O I. the calcium ions are pumped back into the sarcoplasmic reticulum by a Ca++
membrane pump, and they remain stored in the reticulum until a new muscle action
potential comes along
O
-
J. opening of the acetylcholine-gated channels allows e large quantities of sodium ions
to diffuse to the interior of the muscle fiber membrane initiating thus an action
-
myosin
A. each cross-bridge is flexible at two points called hinges - one where the arm leaves
Myosin -
the body of the↳ myosin filament, and the other where the head attaches to the arm
480,000
weight B. the myosin filament is made up of 2 individual myosin molecules x 6
=
I
C. the myosin filament is composed of 4 myosin molecules, each having a molecular
molecule
myosin
=6 polypeptide mains 6
weight of about 480.000
↓Fangira D. the myosin filament is composed of multiple myosin molecules, each having a
likebe
herit
2 heavy mains B-
200,000 each molecular weight of about 480.000
-
& I E. the two heavy chains wrap spirally around each other to form a double helix, which is
4 light
called the tail of the myosin molecule
-
20,000 each
F. the four light chains wrap spirally around each other to form a double helix, which is
x 2
with a molecular weight of about 200.000, and four light chains with molecular
weights of about 20.000 each
H. the myosin molecule is composed of six polypeptide chains - two heavy chains, each
with a molecular weight of about 200.000, and four light chains with molecular
weights of about 300.000 eachX
I. each cross-bridge is flexible at two points called hinges - one where the arm leaves
the body of the actin filament, and the other where the head attaches to the arm
J. the myosin filament is made up of 200 or more individual myosin molecules
33. The following statements about the molecular characteristics of the contractile
filaments are true:- 1200 distance
x1.6 um
NO esA. the total length of each myosin filament is uniform, almost exactly 2.6 micrometers X
cross-bridg B. the myosin filament itself is twisted so that each successive pair of cross-bridges is
in center axially displaced from the previous pair by 120 degrees ensuring that the cross-
for 0.2Nm bridges extend in all directions around the filament
-
C. the total length of each myosin filament is uniform, almost exactly 1.6 micrometers ~
D. the myosin filament itself is twisted so that each successive pair of cross-bridges is
axially displaced from the previous pair by 140X degrees 120°
E. the tails of the myosin molecules are bundled together to form the body of the
X
filament, while many heads of the molecules hang inward to the sides of the body
outward of the body
X
F. the myosin head functions as an ADPase enzyme allowing the head to cleave ATP
0 G. the tails of the myosin molecules are bundled together to form the body of the
filament, while many heads of the molecules hang- outward to the sides of the body
0 H. the myosin head functions as an ATPase enzyme allowing the head to cleave ATP
and to use the energy derived from the ATP’s high-energy phosphate bond to
energize the contraction process
0.
I. there are no cross-bridge heads in the very center of the myosin filament for a
-
distance of about 0.2 micrometer because the hinged arms extend away from the
- -
center
X
J. there are many cross-bridge heads in the very center of the myosin filament for a
distance of about 0.2 micrometer because the hinged arms extend away from the
center
34. The following statements about the molecular characteristics of the contractile
filaments areE false:
e
A. each cross-bridge is flexible at two points called hinges - one where the arm leaves
the body of the myosin filament, and the other where the head attaches to the arm
-
B. the myosin head functions as an ATPase enzyme allowing the head to cleave ATP
and to use the energy derived from the ATP’s high-energy phosphate bond to
-
energize the contraction process
0 C. the myosin filament is composed of many myosin molecules, each having a
-
molecular weight of about 380.000
0 D. the myosin molecule is composed of six polypeptide chains - two heavy chains, each
with a molecular weight ofXabout 200.000, and four light chains with molecular
weights of about 300 ---nows
each center
20000
heads at
O E. there are many cross-bridge heads in the very center of the myosin filament for a
distance of about 0.2 micrometer because the hinged arms extend away from the
center
F. the myosin filament itself is twisted so that each successive pair of cross-bridges is
axially displaced from the previous pair by 120 degrees ensuring that the cross-
--
bridges extend in all directions around the filament
G. the myosin molecule is composed of six polypeptide chains - two heavy chains, each
with a molecular weight of about 200.000, and four light chains with molecular
weights of about 20.000 each - is uniform
0
x
H. the total length of each myosin filament is not uniform and has almost -
-
1.6
micrometers
I. the myosin filament is composed of multiple myosin molecules, each having a
-
molecular2 weight of about 480.000
0 x heavy chains
J. the four light chains wrap spirally around each other to form a double helix, which is
called the tail of the myosin molecule -
35. The following statements about muscle contraction are - false:
0 A. when the muscle fiber is contracted, the length of the sarcomere is about 2
X
micrometers and the actin filaments partially overlap the myosin filaments
completely overlap
B. the light bands contain only actin filaments and are called I bands because they are
-
isotropic to polarized light
C. into sarcoplasm are also present tremendous numbers of mitochondria that lie
parallel to the myofibrils that supply the contracting myofibrils with large amounts of
energy in the form of adenosine triphosphate e
intracellular
A
wid
0 D. the spaces between the myofibrils are filled with extracellular fluid called sarcoplasm,
containing large quantities of potassium, magnesium, and phosphate, plus multiple
protein enzymes
E. the myosin molecule is composed of six polypeptide chains - two heavy chains, each
with a molecular weight of about 200.000, and four light chains with molecular
weights of about 20.000 each V
O F. at each ending, the nerve secretes a small amount of the neurotransmitter substance
acetylcholine which acts on a local area of the muscle fiber membrane to open
T
multiple “acetylcholine-voltage gated” channels through protein molecules floating
in the membrane X notgated
G. the myosin head functions as an ATPase enzyme allowing the head to cleave ATP
and to use the energy derived from the ATP’s high-energy phosphate bond to
energize the contraction process -
H. the action potential depolarizes the muscle membrane and the electricity also flows
through the center of the muscle fiber where it causes the sarcoplasmic reticulum to
release large quantities of calcium ions that have been stored within this reticulum -
0 I. the dark bands contain myosin filaments, as well as the ends of the actin filaments
where they overlap the myosin, and are called I bands because they are anisotropic
7 A bants
*
to polarized light
⑧ J. each muscle fiber contains several hundred to several thousand myofibrils and each
myofibril is composed of about 1500 adjacent actin filaments and 3000 myosin
filaments 7 3000 Actio
36. The following statements about the molecular characteristics of the contractile
filaments are true: Amicrometer
X
X A. each actin filament is about X2 micrometer width and the bases of the actin filaments
are inserted strongly into the Z discs
Rest - B. during contraction,
X
the tropomyosin molecules lie on top of the active sites of the
-
actin strands, so that attraction cannot occur between the actin and myosin filaments
to cause contraction X
XC. each strand of the double F-actin helix from actin filament is composed of
x 42,000
polymerized G-actin molecules, each having a molecular weight of about 40,000
0 D. each strand of the double F-actin helix from actin filament is composed of
-
polymerized G-actin molecules, each having a molecular weight of about 42,000
0 -
E. in the resting state, the tropomyosin molecules lie on top of the active sites of the
actin strands, so that attraction cannot occur between the actin and myosin filaments
I
-
to cause contraction -
X
X F. attached to each one of the G-actin molecules is one molecule of ATP that are the
active sites on the actin filaments with which the cross-bridges of the myosin
filaments interact to cause muscle contraction
0
-
G. attached to each one of the G-actin molecules is one molecule of ADP that are the
active sites on the actin filaments with which the cross-bridges of the myosin
filaments interact to cause muscle contraction
Actin
0 H. each actin filament is about 1 micrometer long and the bases of the actin filaments
-
troponin
J. the actin filament is composed of four protein components: actin, tropomyosin, and
troponin and titin Backbone of Actin: Double Factin protein
-
helix
composed of G-actin molecules 42,000
=
-
1 ↳ ADP
Phosphocreative and
-
Ist= glycolysis brd: Oxidataboli
LDLONG-TERM - Si
37. The following statements about the sources of energy for muscle contraction are true:
A. most of the energy is required to actuate the walk-along mechanism by which the
cross-bridges pull the actin filaments
B. the concentration of ATP in the muscle fiber, about 4 millimolar, is sufficient to
maintain full contraction for only 1 to 2 seconds at most
C. the second important source of energy is “glycolysis” of glycogen previously stored
in the muscle cells
It
D. small amounts of energy are required for pumping calcium ions from the
Ca x
sarcoplasmic reticulum into sarcoplasm after the contraction is over, and for
from pumping sodium and potassium ions through the muscle fiber membrane to
Sacroplasm maintain appropriate ionic environment for propagation of muscle fiber action
↓ potentials
E. most of the energy is required to actuate the walk-along mechanism by which the
reticertur cross-bridges pull the myosin filaments Actin
↳
F. more than 95 % of all energy used by the muscles for sustained, long-term
contraction is derived from oxidative metabolism
G. more than 95 % of all energy used by the muscles for short-term contraction is
derived from oxidative metabolism
0
H. small amounts of energy are required for pumping calcium ions from the sarcoplasm
into the sarcoplasmic reticulum after the contraction is over, and for pumping
sodium and potassium ions through the muscle fiber membrane to maintain
appropriate ionic environment for propagation of muscle fiber action potentials
X
I. the concentration of ADP in the muscle fiber, about 4 millimolar, is sufficient to
maintain full contraction for only 1 to 2 seconds at most
J. the most important source of energy is “glycolysis” of glycogen previously stored in
the muscle cells ↑ 2nd -
small fibres 1-5NM
38. The following statements about smooth muscles are true: 1 nerve
Joined by A. theOuterinner
ending
surfaces of smooth fibers are covered by a thin layer of basement
x
Many A membrane - like substance, a mixture of fine collagen and glycoprotein that helps
GaP insulate the separate fibers from one another
O en
Junctions B. the smooth cell membranes are joined by many gap junctions through which ions
can flow freely from one muscle cell to the next so that action potentials or simple
ion flow without action potentials can travel from one fiber to the next and cause the
muscle fibers to contract together
+ many junction
C. the smooth cell membranes are joined by one single gap junction through which
are ions can flow freely from one muscle cell to the next so that action potentials or
They
so simple ion flow without action potentials can travel from one fiber to the next and
adjacent cause the muscle fibers to contract together
that
- D. the smooth fibers usually are arranged in sheets or bundles, and their cell
Force
can be
membranes are adherent to one another at multiple points so that force generated
transmitted
-> can
in one muscle fiber cannot be transmitted to the next
to the
C
E. smooth muscle is composed of small fibers— usually 1 to 5 micrometers in diameter
and only 20 to 500 micrometers in length
next X
F. smooth muscle is composed of large fibers - usually 1 to 5 micrometers in diameter
and only 20 to 500 micrometers in length
G. the outer surfaces of smooth fibers are covered by a thin layer of basement
membrane - like substance, a mixture of fine collagen and glycoprotein that helps
-
insulate the separate fibers from one another
H. each smooth fiber operates independently of the others and often is innervated by a
Xmany nerve endings X
0 I. the smooth fibers usually are arranged in sheets or bundles, and their cell
membranes are adherent to one another at multiple points so that force generated
in one muscle fiber- can be transmitted to the next
J. each smooth fiber operates independently of the others and often is innervated by a
single nerve ending
39. The following statements about smooth muscle contraction are true:
- A. smooth muscle contains both actin and myosin filaments, having chemical
characteristics similar to those of the actin and myosin filaments in skeletal muscle
but it does not contain the normal troponin complex that is required in the control of
skeletal muscle contraction
x cat
So they B. the contractile process is activated by sodium ions, and adenosine triphosphate is
degraded to adenosine diphosphate to provide the energy for contraction
car hinge a
C. most of the myosin filaments have “sidepolar” cross-bridges arranged so that the
side
in
different &
bridges on one side hinge in one direction and those on the other side hinge in the
opposite direction
directions - 2
X
D. interspersed among the actin filaments in the muscle fiber are myosin filaments
having a length 10 X more than that of the actin filaments
E. smooth muscle contains both actin and myosin filaments, having chemical
characteristics similar to those of the actin and myosin filaments in skeletal muscle
Actin
attaches
DOES NOT ythe normal troponin complex that is required in the control of
and also contains
sh skeletal muscle contraction
O
-
de F. interspersed among the actin filaments in the muscle fiber are myosin filaments
tO
bo
dies having a diameter* more than twice that of the actin filaments
-
G. the contractile process is activated by calcium ions, and adenosine triphosphate is
-
degraded to adenosine diphosphate to provide the energy for contraction
0H. large numbers of actin filaments attached to so-called dense bodies
myosin
I. most of the actin filaments
X
have “sidepolar” cross-bridges arranged so that the
bridges on one side hinge in one direction and those on the other side hinge in the
X
opposite direction ↑ wor
activ Tropomyosin
J. large numbers of myosin filaments attached to so-called dense bodies -
40. The following statements about smooth muscle contraction are true: I - Calmodulin
A. in place of troponin, smooth muscle cells contain a large amount of anotherregulatory
regulatory protein called calsequestrin X protein
B. in place of troponin, smooth muscle cells contain a large amount of another
regulatory protein called calmodulin. cat
...
-
C. the smooth muscle membrane contains many types of receptor proteins that can
⑦
initiate the contractile process
-
D. the calmodulin-calcium combination joins with and activates myosin kinase, a
phosphorylating enzyme
E. the calmodulin-calcium combination joins with and activates myosin phosphatase, a
phosphorylating enzyme x smooth muscle
Gatosol
of
F. the myosin phosphatase is located in the fluids of the smooth muscle cell and splits
the phosphate from the regulatory light chain
-
Er
G. the myosin phosphatase is located in the fluids of the smooth muscle cell and splits
the phosphate from the regulatory heavy chain
chain
Splits Light
with calmodulin activate
& bird calcium-calmodulin myosin kinase
- H. the increase in extracellular calcium ions can be caused in different types of smooth
muscle by nerve stimulation of the smooth muscle fiber, hormonal stimulation,
+ stretch of the fiber, or even change in the chemical environment of the fiber.
-
Ca I. the increase inE intracellular calcium ions can be caused in different types of smooth
muscle by nerve stimulation of the smooth muscle fiber, hormonal stimulation,
-
aie
coming stretch of the fiber, or even change in the chemical environment of the fiber.
J. the smooth muscle membrane contains one single type of receptor proteins that can
inside initiate the contractile process
ending
- 1 nerve
41. The following statements about smooth muscle contraction are false:
A. smooth muscle contains both actin and myosin filaments, having chemical
characteristics similar to those of the actin and myosin filaments in skeletal muscle
but it does not contain the normal troponin complex that is required in the control of
-
skeletal muscle contraction
B. in place of troponin, smooth muscle cells contain a large amount of another
regulatory protein called calsequestrin X
-
C. the increase in intracellular calcium ions can be caused in different types of smooth
muscle by nerve stimulation of the smooth muscle fiber, hormonal stimulation,
stretch of the fiber, or even change in the chemical environment of the fiber.
0
D. each smooth fiber operates independently of the others and often is innervated by a
*
many nerve endings
E. the outer surfaces of smooth fibers are covered by a thin layer of basement
membrane - like substance, a mixture of fine collagen and glycoprotein that helps
insulate the separate fibers from one another W
F. in place of troponin, smooth muscle cells contain a large amount of another
regulatory protein called calmodulin. - catt diffuses inside
Fause as
0
+
G. the increase in extracellular calcium ions can be caused in different types of smooth
muscle by nerve stimulation of the smooth muscle fiber, hormonal stimulation,
stretch of the fiber, or even change in the chemical environment of the fiber.
H. each smooth fiber operates independently of the others and often is innervated by a
single nerve ending e
⑧ I. smooth muscle contains both actin and myosin filaments, having chemical
characteristics similar to those of the actin and myosin filaments in skeletal muscle
and also contains the normal troponin complex that is required in the control of
skeletal muscle contraction A
adjacent
0
J. the smooth fibers usually are arranged in sheets or bundles, and their cell So
membranes are adherent to one another at multiple points so that force generated car
force
n
in one muscle fiber cannot be transmitted to the next be
- transmitted
42. The following statements about smooth muscle contraction areE false:
0
A. the myosin phosphatase is located in the fluids of the smooth muscle cell and splits
the phosphate from the regulatory heavy chainz light chain
E small
small B. smooth muscle is composed of large fibers - usually 1 to 5 micrometers in diameter
-
Junctions -
kinase
myosin
+
kinase
F. the calmodulin-calcium combination joins with and activates myosin phosphatase, a
L
ions can flow freely from one muscle cell to the next so that action potentials or
simple ion flow without action potentials can travel from one fiber to the next and
cause the muscle fibers to contract together -
H. the myosin phosphatase is located in the fluids of the smooth muscle cell and splits
the phosphate from the regulatory light chain -
I. most of the myosin filaments have “sidepolar” cross-bridges arranged so that the
bridges on one side hinge in one direction and those on the other side hinge in the
opposite direction -
J. the smooth cell membranes are joined by many gap junctions through which ions
can flow freely from one muscle cell to the next so that action potentials or simple
ion flow without action potentials can travel from one fiber to the next and cause the
muscle fibers to contract together -
43. The following statements about neuromuscular junction are true:
A. each nerve fiber, after entering the muscle belly, normally branches and stimulates
X
one skeletal muscle fiberHundreds
branching B. the nerve fiber forms a complex of branching nerve terminals that invaginate into the
surface of the skeletal muscle fiber but lie x
outside
inside the nerve plasma membrane
neive C. the motor end plate is covered by one or more Schwann cells that insulate it from
structure the surrounding fluids
- D. each nerve fiber, after entering the muscle belly, normally branches and stimulates
from three to several hundred skeletal muscle fibers
- E. the action potential initiated in the muscle fiber by the nerve signal travels in both
directions toward the muscle fiber ends
F. the action potential initiated in the muscle fiber by the nerve signal travels in one
both Asingle directions toward the muscle fiber ends by using a saltatory conductioninsulate
directions ⑰ DOCS
G. the motor end plate is covered by one or more Schwann cells that cannot insulate it
from the surrounding fluids
- -> posterior
H. the skeletal muscle fibers are innervated by large, myelinated nerve fibers that horns
-
originate from large motoneurons in the anterior horns of the spinal cord
-
-
J. the nerve fiber forms a complex of branching nerve terminals that invaginate into the
-
surface of the skeletal muscle fiber but lie outside the muscle fiber plasma
- -
membrane
44. The following statements about neuromuscular junction are true:
A. acetylcholine is synthesized in the cytoplasm of the terminal, but it is absorbed
rapidly into many small synaptic vesicles, about 300 of which are normally in the
terminals of a single end plate 300000
x
0 -
B. acetylcholine is synthesized in the cytoplasm of the terminal, but it is absorbed
rapidly into many small synaptic vesicles, about - 300.000 of which are normally in the
terminals of a single end plate
⑧ C. in the synaptic space are large quantities of the enzyme acetylcholinesterase, which
destroys acetylcholine a few milliseconds after it has been released from the synaptic
vesicles.
synaptic deft 20-300
=
D. the space between the nerve terminal and the fiber membrane is called the synaptic
x
space or synaptic cleft and has 40 to 50 nanometers wide
ATP
E. in the axon terminal are many mitochondria that supply adenosine diphosphate, the
-
OF G. at the bottom of the gutter are numerous smaller folds of the muscle membrane
called subneural clefts, which greatly increase the surface area at which the synaptic
transmitter can act e
O
&
TD n
H. in the axon terminal are many mitochondria that supply adenosine triphosphate, the
energy source that is used for synthesis of an excitatory transmitter acetylcholine
o ee
I. the space between the nerve terminal and the fiber membrane is called the synaptic
space or synaptic cleft and has 20 to 30 nanometers wide
J. in the synaptic space are large quantities of the enzyme acetylcholinesterase, which
destroys acetylcholine a few seconds after it has been released from the synaptic
vesicles. ~milliseconds resides
- 125
45. The following statements about neuromuscular junction are true:
inside
A. on the
↑
outside surface of the neural membrane are linear dense bars, and to each
on the
side of each dense bar are voltage- gated calcium channels
Inside
surface O B. on the inside surface of the neural membrane are linear dense bars, and to each side
of each dense bar are voltage- gated calcium channels
-Linear Dense
bars= 0
Voltage C. when a nerve impulse reaches the neuromuscular junction, about 125 vesicles of
acetylcholine are released from the terminals into the synaptic space
Sodium gate
D. the acetylcholine vesicles fuse with the neural membrane and empty their inside
voltage-gated
-
x
acetylcholine into the synaptic space by the process of endocytosis.
-
A
E. when an action potential spreads over the terminal, acetylcholine-gated channels calsium
open and allow calcium ions to diffuse from the synaptic space to the interior of the
nerve terminal X
F. when a nerve impulse reaches the neuromuscular junction, about 10 vesicles of
acetylcholine are released from the terminals into the synaptic space
Ca
B
stimulat G. the acetylcholine vesicles fuse with the neural membrane and empty their
-
of
acetylcholine into the synaptic space by the process of exocytosis.
Release H. the effective stimulus for causing acetylcholine release from the vesicles is entry of
-
Acetylcholine calcium ions and that acetylcholine from the vesicles is then emptied through the
resides
from neural membrane adjacent to the dense bars
I. the effective stimulus for causing acetylcholine release from the vesicles is entry of
Latty sodium ions and that acetylcholine from the vesicles is then emptied through the
neural membrane adjacent to the dense bars
0 J. when an action potential spreads over the terminal, voltage-gated calcium channels
open and allow calcium ions to diffuse from the synaptic space to the interior of the
nerve terminal
46. The following statements about neuromuscular junction are- false:
⑧ A. each nerve fiber, after entering the muscle belly, normally branches and stimulates
one skeletal muscle fiber x multiple skeletal fibre
B. the skeletal muscle fibers are innervated by large, myelinated nerve fibers that
originate from large motoneurons in theu anterior horns of the spinal cord
synaptic cleft
C. each nerve fiber, after entering the muscle belly, normally branches and stimulates
from three to several hundred skeletal muscle fibers
D. when a nerve impulse reaches the neuromuscular junction, about 125 vesicles of
acetylcholine are released from the terminals into the synaptic space n
E. at the bottom of the gutter are numerous smaller folds of the muscle membrane
called subneural clefts, which greatly increase the surface area at which the synaptic
transmitter can act
-
F. the space between the nerve terminal and the fiber membrane is called the synaptic
z
space or synaptic cleft and has 40 to 50 nanometers -> wide 20-30nm
0 G. when a nerve impulse reaches the neuromuscular junction, about 10 vesicles of
acetylcholine are released from the terminals into the synaptic space X
0 H. the skeletal muscle fibers are innervated by large, myelinated nerve fibers that
Anterior
originate from large motoneurons in the posterior horns of the spinal cord
-
bottom
O
e
I. at the top of the gutter are numerous smaller folds of the muscle membrane called
-
subneural clefts, which greatly increase the surface area at which the synaptic
transmitter can act
J. the space between the nerve terminal and the fiber membrane is called the synaptic
space or synaptic cleft and has 20 to 30 nanometers wide u
47. The following statements about neuromuscular junction areB false: v
A. when an action potential spreads over the terminal, voltage-gated calcium channels
open and allow calcium ions to diffuse from the synaptic space to the interior of the
nerve terminal
0 B. in the synaptic space are large quantities of the enzyme acetylcholinesterase, which
destroys acetylcholine a few seconds after it has been released from the synaptic
A milliseconts
vesicles.
C. in the synaptic space are large quantities of the enzyme acetylcholinesterase, which
destroys acetylcholine a few milliseconds after it has been released from the synaptic
-
vesicles.
D. acetylcholine is synthesized in the cytoplasm of the terminal, but it is absorbed
rapidly into many small synaptic vesicles, about 300.000 of which are normally in the
- -
membrane
O G. the effective stimulus for causing acetylcholine release from the vesicles is entry of
Xsodium ions and that acetylcholine from the vesicles is then emptied through the
Catt neural membrane adjacent to the dense bars
0 H. the nerve fiber forms a complex of branching nerve terminals that invaginate into the
-outsite
surface of the skeletal muscle fiber but lie inside the nerve plasma membrane
-
I. the effective stimulus for causing acetylcholine release from the vesicles is entry of
calcium ions and that acetylcholine from the vesicles is then emptied through the
u
neural membrane adjacent to the dense bars
I can insulate
0 J. the motor end plate is covered by one or more Schwann cells that cannot insulate it
from the surrounding fluids
48. The following statements about neuromuscular junction are true:
5 subunit:
2x G, P,Y
True i
A. the opened acetylcholine gated ion channel has a diameter of about 0.65 nanometer,
which is large enough to allow the important positive ions - sodium, potassium, and
as
H
chloride to move easily through the opening
because
⑧
8B. the opened acetylcholine gated ion channel has a diameter of about- 0.65 nanometer,
which is large enough to allow the important positive ions - sodium, potassium, and
alpha proteins and one each of beta, delta, and gamma proteins.
xalpha
X E. when two acetylcholine molecules attach respectively to the two beta subunit
proteins a conformational change occur and opens the acetylcholine-gated channel
F. acetylcholine-gated ion channels are located almost entirely near the mouths of the
-
X
subneural clefts lying immediately below the dense bar areas from the muscle
membrane membrane is not muscle
G. acetylcholine-gated ion channels are located almost entirely near the mouths of the
-
alpha proteins and one each of beta, delta, and gamma proteins.
0
I. the negative ions, such as chloride ions, do not pass through acetylcholine gated ion
channel because of strong negative charges in the mouth of the channel that repel
these negative ions. -
J. the negative ions, such as chloride ions, do not pass through acetylcholine gated ion
channel because of strong negative charges in the mouth of the channel that repel
X
these positive ions. -- I do not repel
49. The following statements about neuromuscular junction are true:
XA. most of acetylcholine diffuses out of the synaptic space and is then no longer
available to act on the muscle fiber membrane grane
*
XB. the acetylcholine, once released into the synaptic space, continues to activate
x
- the
ynaptic
acetylcholine receptors as long as the acetylcholine persists in the neural membrane
space
HC. the short time that the acetylcholine remains in the synaptic space—2 seconds at
most—normally is sufficient to excite the muscle fiber - milliseconds
D. each impulse that arrives at the neuromuscular junction causes about ten times as
much end plate potential as that required to stimulate the muscle fiber
0E. the short time that the acetylcholine remains in the synaptic space—a few
milliseconds at most—normally is sufficient to excite the muscle fiber
0
F. the sudden insurgence of sodium ions into the muscle fiber when the acetylcholine
-
-
channels open causes the electrical potential inside the fiber at the local area of the
-
O J. a small amount of acetylcholine diffuses out of the synaptic space and is then no
longer available to act on the muscle fiber membrane aton of
50. The following statements about neuromuscular junction are
x-
- oferminal
false: I
nerve
-
A. acetylcholine is synthesized in the cytosol of the muscle fiber but is immediately cell
transported through the membranes of the vesicles to their interior, where it is
-
-
stored in highly concentrated form
B. on the inside surface of the neural membrane are linear dense bars, and to each side
of each dense bar are voltage- gated calcium channels
C. myasthenia gravis is an autoimmune disease in which the patients develop
antibodies against their own acetylcholine-activated ion channels and the
neuromuscular junctions are unable thus to transmit enough signals from the nerve
to the muscle fibers.
D. the short time that the acetylcholine remains in the synaptic space—a few
milliseconds at most—normally is sufficient to excite the muscle fiber -
E. the opened acetylcholine gated ion channel has a diameter of about 0.65 nanometer,
-
which is large enough to allow the important positive ions - sodium, potassium, and
calcium to move easily through the opening -
-
-
F. when an action potential arrives at the nerve terminal, it opens many calcium
channels in the membrane of the nerve terminal because this terminal has an
voltage-gated Calaum
x
abundance of acetylcholine-gated calcium channels
-
Channels
G. the number of vesicles available in the nerve ending is sufficient to allow
x Thousands!
transmission of only one nerve-to-muscle impulse
-
alpha
-
⑧ H. when two acetylcholine molecules attach respectively to the two beta subunit
proteins a conformational change occurs and opens the acetylcholine-gated channel
"
I. acetylcholine is split by acetylcholinesterase into acetate ion and choline, and the
acetate is reabsorbed actively into the neural terminal to be reused to form new
-
called subneural clefts, which greatly increase the surface area at which the synaptic
-
51. The following statements about red blood cells are true:
A. blood transports enormous quantities of CO2 from the tissues to the lungs
B. carbonic anhydrase catalyzes the irreversible reaction between carbon dioxide and
x
water to form carbonic acid reversible
C. the average volume of the red blood cells is 90 to 95 cubic micrometres
D. red blood cells cannot be deformed in any shape
Car be free
in
X
E. haemoglobin never circulates as free protein in the plasma
-
plasma
but leaks to El
F. a major function of erythrocytes is to transport haemoglobin
G. in healthy men, the average number of erythrocytes per cubic millimetre is 5.2 million
(± 300 000)
x concave
H. normal red blood cells are biconvex disks
0 I. red blood cells are responsible for most of the acid-base buffering power of the
blood
-
anhydrase
52. The following statements about red blood cells are true:
Co2&H2CO3 Carbonic=
A. in women, the average number of erythrocytes is 4,7 million (± 300 000) anhydrase
B. the blood transports enormous quantities of bicarbonate ions from the lungs to the
tissues 3%
x
C. when it is free in the plasma, about 12 per cent of the haemoglobin leaks through
the capillary membrane into the tissue spaces
D. normal red blood cells are biconcave disks -
E. the shapes of red blood cells can change as the cells squeeze through capillaries
F. each gram of haemoglobin can combine with 3.14 ml of oxygen
G. carbon anhydrase is an enzyme that catalyzes the reversible reaction between CO2
and H2O
H. in normal conditions, the whole blood of men contains an average of 20 grams of
haemoglobin blood
greater, need more
x
I. people living at high altitudes have fewer red blood cells ↓
-
Oz
J. red blood cells can concentrate haemoglobin up to about 34 grams in every 100
millilitres of cell
-
53. The following about the production of RBCs and the genesis of blood cells are true:
A. after birth, RBCs are produced exclusively in the spleenx liver
X B. interleukin-3 promotes the growth and reproduction of all different types of
Growth committed - stem cells - beginning
Inducer C. all the cells of the circulating blood are derived from the pluripotential hematopoietic
-
stem cell
-
D. during the middle trimester of gestation, the bone marrow is the main organ for the
production of RBC
xNO
E. a mature erythrocyte contains a significant amount of basophilic material
F. the growth inducers promote both the growth and differentiation of the cellsblood
very littleb X
G. the basophil erythroblasts are filled with haemoglobin almost entirely squeezing
capillary
H. squeezing through the pores of the capillary membrane is calledA
- -
diapedesis ->
I. in the early weeks of embryonic life, nucleated erythrocytes are produced in the yolk
-
sac
-
e
- &
erythrocytes
54. The following about the production of RBCs and the genesis of blood cells are true:
X
A. RBCs are never produced in the lymph nodes & spleen
B. -
differentiation inducers promote the differentiation of the cells
C. exposure of the blood to low oxygen for a long time causes growth induction of
RBCs
x small
D. the reticulocytes contain a large amount of basophilic material, consisting of the
Golgi apparatus, mitochondria and cytoplasmic organelles
Gre
E. growth inducers control the growth and reproduction of the different stem cells
F. the bone marrow of the proximal portions of the humeri and tibiae no longer
produces RBC after the age of 20 years
-
-
G. proerythroblast is the first cell identified as belonging to the RBC series
E
-
H. up until the age of 20 most RBCs are produced in the marrow of the membranous
bones
squeezing through
capillary
J. infectious diseases can cause the growth, differentiation and formation of specific
types of white blood cells
55. The following statements about the production and maturation of red blood cells are
true: Iypoxia =
A erythropoietin= ARBC production
A. the maturation and rate of production are affected by a person’s nutritional status
B. norepinephrine inhibits erythropoietin production Adrenaline ARBCs
-
C. 90 per cent of the erythropoietin is formed in the liver kidney
x
Heart (I
D. in cardiac failure, the haematocrit and total blood volume are increased
stopped E. at very high altitudes, the quantity of oxygen in the air is greatly increased, and so
pumping RBC production is decreased without
7 has no effect
Les F. hypoxia stimulates RBC production, even in the absence of erythropoietin
etab G. folic acid is especially important for the final maturation of the RBCs
-
weg 0H. a decrease in oxygenation will increase the rate of RBC production
DI. erythropoietin is the main stimulus for RBC production in low-oxygen states
J. vitamin B6 is especially important for the final maturation of the RBCs
X
B12 -
Biitamin
56. The following statements about the production and maturation of red blood cells are
true: ↓Kidney O2= 4HVF-1=erythropoietic
x increased
A. renal tissue hypoxia leads to decreased tissue levels of hypoxia-inducible factor-1
x B12
B. pernicious anaemia is caused by failure to absorb folic acid 90% liver
x =
10... kidney
Vitamin B12 C. 10 per cent of A the normal erythropoietin is formed in the spleen
stimulate
D. prostaglandins inhibit erythropoietin production
8 Falicacit
-
is needed
E. pernicious anaemia consists of an atrophic gastric mucosa
->
notsecretion in
Stomach
F. lack of either vitamin B12 or folic acid causes abnormal DNA and, consequently,
for RBL to
-
RBCs I. if the erythroblastic cells fail to proliferate rapidly, microcytes will be produced
·
of
J. most of the erythropoietin is secreted by fibroblast-like interstitial cells surrounding
- -
57. The following statements about the maturation of red blood cells are true:
-
-
+
E. folic acid found in vegetable and fruits are hardly destroyed during cooking
⑧F. deficiency of vitamin B12 or folic acid causes maturation failure in the process of
erythropoiesis -
B12
G. pernicious anaemia is caused by failure to absorb cyanocobalamin-> Vitamin
H. cyanocobalamin is stored in large quantities in the spleen
I. 3 to 4 months of defective B12 absorption are required to cause maturation failure
anaemia x years
⑧ J. macrocytes have a flimsy membrane and are irregular, large and oval -
short life
58. The following statements about haemoglobin are true: Fragile
A. synthesis of haemoglobin begins in the proerythroblasts valine-gluta
-
ri
lid
B. in sickle cell anaemia, the amino acid glutamic acid is substituted for valine Reverse
a
make
↓ groups
B. the elongated crystals inside RBCs in sickle cell anaemia help the cells to pass
through capillaries =4 Fet
0 C. haemoglobin A is a combination of two alpha and two beta chains e
⑳
E. one haemoglobin molecule contains four iron atoms -
=reversible
F. globin is synthesized by the Golgi apparatustribosomes
G. eight oxygen atoms can be transported by each haemoglobin molecule
H. the oxygen in combination with haemoglobin becomes ionic oxygen
x
I. in sickle cell anaemia, the amino acid valine is substituted for glutamic acid
A
J. the most common form of haemoglobin in adult human beings is the haemoglobin B x
60. Iron metabolism:
0A. iron combines in the blood plasma with apotransferrin to form transferrin
B. transferrin bound with iron is ingested into the erythroblasts by endocytosis
65%
-
-
it
XC. 15 to 30 per cent of iron is in the form of haemoglobin
-
D. excess iron in the blood can be deposited in the bone marrow
E. ferritin can only contain small amounts of iron
F. a man excretes 0,6 mg of iron each day, mainly through urine
G. iron is essential for the formation of catalase KiUS H2O2
-
=
I here
so blood not toxic
H. iron is tightly bound in the transferrin
15-30% is
0I. the total quantity of iron in the body averages 4 to 5 grams
-
Feriritin
E. storage iron is the iron stored as transferrinx
-
F.
-
in the cell cytoplasm, iron combines mainly with apoferritin to form ferritin
-
0
I. 0.1 per cent of iron is combined with transferrin
J.
-
when the iron stores have become depleted, the rate of absorption can accelerate
five times normal
62. The following about the life span of RBCs and the destruction of haemoglobin are
true: part of Mb -> Br
A. the porphyrin portion of the - haemoglobin molecule is converted into bilirubin
-
G. when the RBCs burst, the haemoglobin is phagocytized especially by the Kupffer cells
of the spleen
⑧
H. mature RBCs do not have mitochondria or endoplasmic reticulum -
I. the cytoplasmic enzymes of RBCs maintain membrane transport of ions
J. RBCs normally circulate for an average of 60 days before being destroyed ~ 120 days
63. The following statements about anaemias are true:
↑
A. exposure to high-dose radiation can induce aplastic anaemia Radiation/Toxic
MEG Alobastic
B12 =
=
aplastic needs
C. the viscosity of the blood does not depend on the blood concentration of RBCs -
Iranfu
RBC
*
D. in erythroblastosis fetalis a large number of early blast forms of RBCs are released
-
-
-
Sio
from the bone marrow into the blood
0
E. anaemia means deficiency of haemoglobin in the blood ↓Hb -
F. in blood loss anaemia, the body replaces the fluid portion of the plasma in 1 to 3
days
G. in hereditary spherocytosis, the cells have an abnormal type of haemoglobin, called
haemoglobin S
H. after rapid haemorrhage, the body replaces the fluid portion of the plasma within 3
to 6 weeks X (D) 1-3 days ofRBL
ToxiL
Failure
I. high doses of benzene in gasoline may cause aplastic anaemia
J. in chronic blood loss, normal erythrocytes are replaced by macrocytes
-
microcytes
64. The following statements about anaemias are true: small RBC
Aplastic
*
A. high doses of insecticides may lead to haemolytic anaemia
-
> Toxic
B. blood transfusions or bone marrow transplantation are the treatment for severe
aplastic anaemia
-
x There
C. because of the spherical shape of RBC in hereditary spherocytosis, the cells are not as
easily ruptured as the biconcave ones Folizt B12
O D. a deficiency of folic acid results in megaloblastic anaemia
E. in chronic blood loss, a person cannot absorb enough iron from the intestine to form
-
Lz=
peripheral tissue blood vessels to constrict Dilate
Removing parts
of stomach 0.3%.
x
*
E. sickle cell anaemia is present in 30 per cent of West African and American blacks
F. the intrinsic factor has no role in the development of megaloblastic anaemia
RBCs
G. total gastrectomy can lead to megaloblastic anaemia->Large
-H. in bone marrow aplasia there is a lack of functioning bone marrow
I. in anaemia, there is a decreased cardiac output
Aplastic
*
J. chemotherapy for cancer treatment can lead to haemolytic anaemia
66. The following statements about anaemias are true:
A. in erythroblastosis fetalis, Rh-negative RBCs in the fetus are attacked by antibodies
negativex
from an Rh-positive mother i
immunister attackswn tissues
B. autoimmune disorders, such as lupus erythematosus, may lead to aplastic anaemia
-
- F. in about half of the aplastic anaemia cases, the cause is unknown, a condition called
idiopathic aplastic anaemia
Destroyed u G. in pernicious anaemia, the stomach mucosa is atrophied e
C
quicker -
H. in haemolytic diseases, the life span of RBCs is short and the cells are destroyed
than
it faster than they can be formed u
can
be I. in anaemia, the heart is capable of pumping much greater quantities of blood than it
does usually It cannot, so anemic people shouldn't do cardio
replaced J. sickle cell anaemia can lead, in some cases, to death within a few hours exercise
-
67. The following statements about leukocytes are true:
A. there are more WBCs in the blood than RBCs X
B. the plasma cells are formed in the bone marrow
+as
C. WBCs are not stored in the bone marrow, they are only circulating in the blood -
W D. the leukocytes are the mobile units of the body’s protective system -
O E. lymphocytes are formed both in the bone marrow and in the lymph tissue phagocytosis
x
F. WBCs prevent diseases by destroying invading bacteria or viruses by endocytosis
-
-engrif
8
G. granulocytes are formed in the bone marrow
H. the myelocytic lineage begins with the myeloblast
- i
bacteria
I. 5.3 per cent of the total WBCs is represented by neutrophils x 65%
⑧
J. there are six types of WBCs normally present in the blood ~6 plasma =
·
B. platelets neutrophil 62%
=
C. megaloblasts X
"
D. lymphocytes e
E. plasma cells -
F. polymorphonuclear neutrophils -
G. basophils W
H. erythrocytes X
I. megakaryocytes
Lymphocyte = 30%
J. sickle cells X
platelet
38
=
mphoid E. two major lineages of WBCs are formed, the myelocytic and the lymphocytic lineages
F. the lymphocytes are mostly stored in the various lymphoid tissues
by
tissues
e
- + BlOOd
G. the neutrophils attack and destroy bacteria only in the tissues to
macrophage
H. phagocytosis is the cellular ingestion of an offending agent move towards
-
D I. the immune system of the body develops antibodies against infectious agents
x100 - chemical
J. chemotaxis is effective only 5 to 10 micrometres away from an inflamed tissue
t
73. The following statements about the neutrophils and macrophages are true: W
A. degenerative products of the inflamed tissues can cause chemotaxis very
Bacteria e effective
toxins away 1000m
bacteria
X
-
3-20 100 bacterich
B. neutrophils are much more powerful phagocytes than macrophages
C. different chemical substances through chemotaxis cause neutrophils to move toward
the source of the chemical
D. neutrophils can squeeze through the pores of the blood capillaries by diapedesis
E. chemotaxis depends on the - concentration gradient of the chemotactic substance
F. the protein coat on the natural substances of the body attracts the phagocytes
G. phagocytes are not selective of the material that is phagocytized
H. smooth surfaces of the structures in the tissues increase phagocytosis
I. once the monocytes enter the tissues, they begin to swell to as much as 60 to 80
micrometres
J. a single neutrophil can phagocyte only one bacteria before it becomes inactivated
and dies monocyte-macrophage,respond emotaxis
74. The following statements about the reticuloendothelial system are true:
-
A. lymph enters through the lymph node capsule by way of efferent lymphatics
B. Kupffer cells are the alveolar macrophages in the lungs
C. histiocytes are the tissue macrophages in the skin and subcutaneous tissues
BacteriaD. invading organisms can enter the body through the lungs lymph nodes, Gl
-
E. macrophages can remain attached to the tissues for months or even years until they
can perform their protective functions carry out their DUTY
Gl
A F. Kupffer cells can phagocyte a single bacterium in less than 0.01 second
-
G. all bacteria can be absorbed directly through the capillary membranes into the blood
H. the skin is mainly impregnable to infectious agents
I. from the afferent lymphatics, the lymph empties into the venous blood
J. through the cords of the red pulp unwanted debris in the blood is phagocyted,
except red blood cells
75. The reticuloendothelial system is formed by: monocytes mobile
=> macrophage
-
A. neutrophils
B. leukocytes Lymph nodes -fixed
C. megakaryocytes
specialised endothelial cell
D. myeloblasts
in bone marrow, spleen
E. specialized endothelial cells in the bone marrow
nodes.
F. mobile macrophages
-
& Gymph
G. fixed tissue macrophages
-
capillaries
vasoaatstity aranda
H. myelocytes
I. monocytes
- is
te
F. within the first hour, after inflammation begins, large numbers of neutrophils begin
to invade the inflamed area from the blood
Dilation
G. inflammation is characterized by vasoconstriction of the local blood vessels
H. inflammatory cytokines cause the intercellular attachments between the endothelial
cells of the capillaries and small venules to tighten
Lethal Toxins migrate
Staphylococi = +
less destruction i
streptococci
causes
=
neutrophils
G. when streptococci invade tissue, they release extremely lethal cellular toxins
H. interleukin-1 (IL-1) is formed mainly by granulocytes, and in smaller quantities by
activated macrophage
I. the tissue cells swell during inflammation
1 J. monocytes require 8 hours or more to swell and develop large quantities of
lysosomes
79. The following statements about inflammation are true:
A. it takes 3 to 4 hours for newly formed granulocytes and monocytes to leave the bone
marrow
B. macrophages play an important role in initiating the development of antibodies
C. staphylococci do not cause an intense local tissue destruction
D. selectins have a decreased expression in inflammation
E. in inflammation, there is an excess of local blood flow - >
D F. there is increased permeability of the capillaries -
G. neutrophil invasion provides the first line of defence against infection M -oneutrophil
H. neutrophils crawl directly from the blood into the tissue spaces by diapedesis
-
I. the build-up of macrophages in the inflamed tissue is much more rapid than that of
neutrophils X
J. cytokines cause chemotaxis of the neutrophils toward the injured tissues -
me
80. The following statements about inflammation are true:
XA. neutrophils can phagocytize far more bacteria and far larger particles than can
-
macrophages
B. even though the stimulus from the inflamed tissue continues, the bone marrow stops
producing granulocytes and monocytes after 3 to 4 days -
X
C. tissue macrophages invasion of the inflamed area is the second line of defence
O-migration
D. during margination, neutrophils stick to the capillary and venule walls in the inflamed
area of WBCs
E. in inflammation, large numbers of granulocytes and monocytes migrated into the
tissue ~
F. cytokines cause increased expression of selectins and intercellular adhesion
molecule-1 (ICAM-1) in the surface of endothelial cells e
G. only two factors are involved in the control of the macrophage response to
inflammation, TNF and IL-1
H. the fourth line of defence is the increased production of granulocytes and monocytes
by the bone marrow clotting
-
inflammation
J. macrophages require minutes to hours to become effective
81. The five factors with a dominant role in the control of macrophage response to
TE nte"
inflammation are:
A. granulocyte colony-stimulating factor (G-CSF) R
Granulocy
B. oncostatin M (OSM) GM-CSF:monocyte
C. thymic stromal lymphopoietin (TSLP)
G-CSF Granology
=
D. interleukin-1 (IL-1)
E. transforming growth factor beta (TGF-β) M-CSF monocyte
=
83. The following statements about eosinophils and basophils are true:
A. the rupture of eosinophils releases large quantities of slow-reacting substance of
anaphylaxis
B. eosinophilic chemotactic factor causes eosinophils to migrate toward the inflamed
allergic tissue
C. histamine is released by the mast cells and basophils
D. eosinophils in the circulating blood are similar to the large tissue mast cells outside
of the capillaries
E. immunoglobulin D becomes attached to mast cells and basophils
F. eosinophils are weak phagocytes
G. basophils release highly reactive forms of oxygen that are lethal to parasites
H. eosinophils are produced in large numbers in people with parasitic infections
I. eosinophils constitute about 2 per cent of all the blood leukocytes
J. eosinophilia does not occur in allergic reactions X-basophil
84. The following statements about immunity are true:
* A. natural killer lymphocytes cannot recognise and destroy tumour cells
B. phagocytosis of bacteria and other invaders by white blood cells is an example of
innate acquired immunity X
I 0 C. natural killer lymphocytes can recognise and destroy foreign cells and even some
Birth infected cells
D. destruction of swallowed organisms by the acid secretions of the stomach is an
example of acquired immunity innate immunity
-
⑧
E. immunity is the human body’s ability to resist almost all types of organisms or toxins
that tend to damage the tissues and organs
0 F. resistance of the skin to invasion by organisms is an example of innate immunity
0G. innate immunity is an additional element of immunity that results from general
processes
H. lysozyme reacts with and inactivates certain types of gram-positive bacteria
I. the complement system is a system of about 20 proteins that can be activated in
-
0I. basic polypeptides react with and inactivate certain types of gram-positive bacteria
⑧J. phagocytosis of bacteria and other invaders by white blood cells is an example of
innate immunity
86. The following statements about acquired immunity are true: -
must be
A. proteins and large polysaccharides are almost always antigenic
0
B. the activated lymphocytes are B lymphocytes X T -
heavy.
Acquired immunity
- needs Antigens
cell-mediated A lotof Humoral-develops
-
a
ated and/or activated lymphocytes that attack and destroy the specific invading organism
-
or toxin
same G. each toxin almost always contains one or more specific chemical compounds in its
e
as makeup that are different from all other compounds
Acquired H. the lymphoid tissue of the thymus plays a role in intercepting antigenic agents that
have reached the circulating blood
I. lymphocyte-committed stem cells of the embryo are capable of forming directly
either activated T lymphocytes or antibodies
J. even if a person has a genetic lack of lymphocytes, acquired immunity can develop
87. The following statements about acquired immunity are true:
A. antigens are proteins or large polysaccharides that initiate the acquired immunity -
B. the lymphoid tissue of the spleen plays a role in intercepting antigenic agents that
-
B have reached the circulating blood
**
C.X T lymphocytes produce the antibodies
D. cell-mediated immunity is also called B-cell immunity X
E. both humoral and cell-mediated immunity are initiated by antigens =7Acquired
F. large polysaccharides are never antigenic X
E G. epitopes are located inside a small moleculeX
Surface
H. even if a person's lymphocytes have been destroyed by radiation or chemical,
acquired immunity can develop
-
I. antibodies are globulin molecules in the blood plasma capable of attacking the
invading agent
J. lymphocytes are responsible for acquired immunity ~
88. The following statements about acquired immunity are true:
A. most of the pre-processing of the T lymphocytes in the thymus occurs only in adult
life
B. the activated lymphocytes are T lymphocytes
Activated
-
G. T lymphocytes leaving the thymus will react against proteins or other antigens
present in the body’s own tissue
H. only 10 per cent of the T lymphocytes are destroyed and phagocytized instead of
being released HIGHweight
I. for a substance to be antigenic, it usually must have a low molecular weight
X
J. humoral immunity is also called B-cell immunity
89. The following statements about acquired immunity are true:
A. removal of the thymus gland after birth eliminates the T-lymphocytic immune system
B. only humoral immunity is initiated by antigens X humoral + cell-mediated.
OC. for a substance to be antigenic, it usually must have a high molecular weight of 8000
or greater -
-
-
D. proteins are never antigenic
E. activated T lymphocytes are specifically crafted in the lymph nodes to destroy the
-
foreign agent
0 F. cell-mediated immunity is also called T-cell immunity
- G. the process of antigenicity usually depends on- epitopes
H. lymphocytes are located most extensively in the thymus -
I. lymphocytes are not essential to the survival of the human being X
0 J. B lymphocytes produce the antibodies -
90. The following statements about acquired immunity are true:
- A. lymphocytes are also located in the bone marrow +liver
B. removal of the thymus several months before birth does not affect the development
of all cell-mediated immunity
0 C. in people who have a genetic lack of lymphocytes, no acquired immunity can
develop
D. surface receptor
* I
proteins are on the surface of the B-cell membrane
E. each clone of lymphocytes is responsive to hundreds of different types of antigensX
⑧ F. the lymphoid tissue in the lymph nodes is exposed to antigens that invade the
peripheral tissues of the body
G. the B lymphocytes are pre-processed in the liver during mid-fetal life +Bonarrow
Greater
-
X H. the B lymphocytes have less diversity than the T lymphocytes
& I. acquired immunity is the product of the body’s lymphocytes
& J. there are millions of genes that code for the several hundred different types of
antibodies and T lymphocytes
91. The following statements about acquired immunity are true:
A. the whole gene for forming each type of T cell or B cell is always present in the
original stem cells
B. each B lymphocyte has on its cell surface membrane 1 to 10 antibody molecules
F. T lymphocytes that are reactive against the body’s own antigens are also released
from the thymus
-
G. in most instances, the invading agent first enters the tissue fluids and then is carried
by lymph vessels to the lymph node or other lymphoid tissue
H. T-cell markers are different from antibodies
0 I. lymphocytes are essential to the survival of the human being
J. the lymphoid tissue of the gastrointestinal walls is exposed to antigens invading from
-
the gut & lymph nodes in throat
92. The following statements about acquired immunity are true:
Lymphocytes A. the lymphoid progenitor cells that are destined to eventually form activated T
lymphocytes first migrate to the thymus gland
first migrate B. surface receptor proteins are not specific for one specified activating antigen
to the
Thymo) C. the lymphoid tissue of the tonsils and adenoids is well located to intercept antigens
-
gland
-
macrophage
x
macrophage
G. lymphocytes secrete a special activating substance called interleukin-1
0 H. the lymphoid tissue is distributed advantageously in the body to intercept invading
organisms or toxins before they can spread too widely
I. most antigens activate only one type of lymphocytes x 2 0B
+
J. most invading organisms first activate specified lymphocytic clones, and then, they
are phagocytized and digested by the macrophages
93. The following statements about acquired immunity are true:
A. T lymphocytes are called so to designate the role of the thymus
xproduce it
-
glayse- birth
I. lymphocytes are derived originally in the embryo from pluripotent hematopoietic
stem cells
-
X Dormant iSt
J. before exposure to a specific antigen, the clones of B lymphocytes are active, then
they become dormant in the lymphoid tissue
94. The following statements about acquired immunity are true:
A. the T lymphocytes, after origination in the bone marrow, divide rapidly in the thymus
gland -
B. lymphoblasts produce gamma globulin antibodies at an extremely slow rate
C. 90 per cent of the T lymphocytes are destroyed and phagocytized instead of being
-
released
D. interleukin-1 inhibits the further growth and reproduction of the specific
lymphocytes
E. a subsequent exposure to the same antigen will cause a much slower and weaker
antibody response the second time around X
F. T lymphocytes leaving the thymus will not react against proteins or other antigens
present in the body’s own tissue =Deadly
G. after they leave the thymus different types of pre-processed T lymphocytes spread
v
by way of the blood throughout the body to lodge in lymphoid tissue everywhere
H. most of the pre-processing of T lymphocytes in the thymus occurs shortly before the
birth of a baby and for a few months after birth
I. the plasmablasts divide at a rate of about once every hour for about 2 divisions
J. lymphokines inhibit the activation of specific B lymphocytes X
95. The following statements about acquired immunity are true:
A. gamma globulin antibodies are produced at an extremely slow rate
O
B. an antigen activates only the lymphocyte that has cell surface receptors that are
complementary W
C. if a T lymphocyte reacts with self-antigens from the body’s own tissues, it is
destroyed and phagocytized
thee
Blymphops, light
⑭Activate
D. all the immunoglobulins are composed only of light polypeptide chains
E. the constant portion of the antibody is different for each specific antibody
F. the only cells that are finally released are those that are nonreactive against the
body’s own antigens
Born with it
-
Ig 5
-
=
all cell-mediated immunity
blood B. the B lymphocytes actively secrete antibodies that are the reactive agents -
%
-
C. clone of lymphocytes are all the different lymphocytes that are capable of forming
Antibody -
X
J. the amino acid organization of all antigens have the same steric shape
different
shapes
98. The following statements about acquired immunity are true:
A. between the antibody and the antigen there is a slow and loose bonding
macropha B. interleukin-1 promotes further growth and reproduction of the specific lymphocytes
C. T-cell markers are highly specific for one specified activating antigen un
- -
-
D. most antigens activate both T lymphocytes and B lymphocytes at the same time
E. most invading organisms are first phagocytized and partially digested by the
macrophages
-
x Itdoes
F. the antibody-antigen coupling does not obey the thermodynamic mass action law
X
G. when the antibody is highly specific, there is only one bonding site 2 binding sites
H. the prosthetic groups of the antigen do not fit properly with those of the antibody
7
They so "
~y
I.aside from the lymphocytes in lymphoid tissue, millions of macrophages are also
-
-
0A. before exposure to a specific antigen, the clones of B lymphocytes remain dormant
in the lymphoid tissue. Need to be activated
+
I. through agglutination the antibodies cover the toxic sites of the antigenic agent
0J. subsequent exposure to the same antigen will cause a much more rapid and much
more potent antibody response the second time around
101. The following statements about acquired immunity are true:
O A. antibodies are gamma globulins called immunoglobulins e
B. most of the protection comes through the direct actions of antibodies, and not
through the effects of the complement system
~
C. IgG constitutes only a small percentage of the antibodies
Neutralis. X
D. agglutination is the only way antibodies can inactivate the invading agent
Lysis E. the immunoglobulin has a variable portion, as well as a constant portion r
⑧ secreted by T
0 F. lymphokines activate the specific B lymphocytes but are
cover - -
G. neutralization,
7
in which some potent antibodies are occasionally capable of directly
Toxic sit attacking membranes of cellular agents and thereby causing rupture of the agent
Antigen 0 H. Ig stands for immunoglobulin
& I. formation of memory cells enhances the antibody response to subsequent antigen
exposure + 20
J. the complement system contains 3 to 5 proteins
102. The following statements about antibodies are true:
-
A. the variable portion is different for each specific antibody
-
B. a combination of noncovalent and covalent bonds holds the light and heavy chains
together
+ Different
shapes
C. the amino acid organization of all antigens have the same steric shape 00
=2
D. when the antibody is highly specific, there is only one bonding site Y
E. antibodies are not specific for particular antigens X
-
OF. the constant portion of the antibody establishes antibody diffusivity in the tissues
-
-
G. the constant portion of the antibody establishes the attachment to the complement
complex
H. the variable portion attaches specifically to a particular type of antigen
-
x
I. between the antibody and the antigen, there is a slow and loose bonding
J. the prosthetic groups of the antigen do not fit properly with those of the antibody
103. The following statements about antibodies are true:
OA. the amino acid organization has a different steric shape for each antigen specificity
X B. only covalent bonds hold the light and heavy chains together
- C. when an antigen comes in contact with the antibody, multiple prosthetic groups of
O
the antigen fit as a mirror image with those of the antibody
-
XD. the constant portion of the antibody attaches specifically to a particular type of
antigen
XE. the variable portion of the antibody is responsible for the biological properties of the
antibody
⑧
F. each antibody has a unique structural organization of amino acids in the variable
portions of both the light and heavy chains
-
- G. between the antibody and the antigen, there is a rapid and tight bonding
H. each antibody is specific for a particular antigen x
does
it
I. the antibody-antigen coupling does not obey the thermodynamic mass action law
X
J. the variable portion determines the properties of the antibody, such as attachment
X
to the complement complex
104. The antibody-antigen coupling is exceedingly strong, held together by:
8
A. ionic attractions
⑧ B. hydrogen bonding
C. Fajans' rules
D. thermodynamic mass action law
-
E. London forces
F. Madelung constant
a
G. hydrophobic bonding
H. van der Waals forces
I. metallic bonding
X
J. hydrophilic bonding
105. The classes of antibodies are:
A. IgE
B. IgS A, D, E, G, M
C. IgB
D. IgP
E. IgC
F. IgA
G. IgG
75
1gG =
H. IgV
IgE Allerge
=
⑲G Fe
F. IgE constitutes 75 per cent of the antibodies of a normal person
-
D. agglutination, in which the antibodies cover the toxic sites of the antigenic agent
E. the direct actions of antibodies often are not strong enough to play a major role in
W
protecting the body against the invader
F. lysis, in which some potent antibodies are occasionally capable of directly attacking
-
Antibody
B. the classical pathway is initiated by an antigen-antibody reaction
-
I
C. the enzyme precursors can be activated by the classical pathway ② classical
D. the complement system does not cause agglutination X pathway
E. many of the complement system's proteins are- enzyme precursors ↓
F. the enzyme precursors are inactivated by the classical pathway Enzyme
~
G. complement system describes a system of about 20 proteins
x
precursor
H. when an antibody binds with an antigen, a specific reactive site on the variable
portion of the antibody becomes activated
I. the enzyme precursors are normally inactive
J. the C1 enzymes inactivate the cascade of sequential reactions
110. The most important effects of the complement system are:
A. barotaxis
B. activation of erythrocytes A
C. activation of plasmablasts
↳
D. agglutination - Basophil
E. activation of basophils receases
- F. opsonization +
phagocytosis histamine t
G. precipitation
H. lysis Heparin
I. diffusion A
Increase d
J. chemotaxis
-
Bere
111. The most important effects of the complement system are:
A. neutralization e
B. aggregation
C. inflammatory effects
-
- 2
F. there are 3 to 5 antigens on the surfaces of the RBCs
G. people may have neither A nor B antigens on their cells
H. agglutinogens cause blood cell agglutination
I. the agglutinogens are found inside - the RBCs
-
surface
J. blood transfusion reactions never happen
116. The following statements about the O-A-B blood types are true: X
A. when A agglutinogen is present, and B agglutinogen is absent, the blood type is B
B. there are four major O-A-B blood types
C. when only type A agglutinogen is present, the blood is type B
D. when neither A nor B agglutinogen is present, the blood is type O
E. when both A and B agglutinogens are present, the blood is type O
F. when neither A nor B agglutinogen is present, the blood is type AB
G. when both A and B agglutinogens are present, the blood is type AB
H. when only type A agglutinogen is present, the blood is type A
I. when only type B agglutinogen is present, the blood is type B
J. when only type B agglutinogen is present, the blood is type A
117. The following about the genetic determination of the agglutinogens are true:
X
A. the type A allele is recessive to both the O and B allele
B. the type O allele causes no significant type O agglutinogen on the cells
C. the type A and B alleles cause strong agglutinogens on the cells
D. the type B allele is functionless
E. the type O allele causes strong agglutinogen on the cells
F. the type O allele is either functionless or almost functionless
G. the ABO blood group genetic locus has three alleles NOT
H. the alleles IA, IB and IO determine the three blood types xGroups
I. the type B is recessive to both the O and A allele
-
anti-B agglutinins
J. when type B agglutinogen is not present in a person's RBCs, antibodies known as
anti-B agglutinins develop
122. The following statements about agglutinins are true: hemolysin
I
A. a maximum titre is usually reached at 8 to 10 years of age 2
10
--IgM
B. the agglutinins are alpha globulins gamma
C. most agglutinins are IgE immunoglobulin molecules 1gG
+
O
D. the agglutinins are gamma globulins
node
E. the agglutinins are produced only by the bone marrow +lymph
X
F. infusion of group B antigen into a recipient having a non-A blood type causes a
Amount
Antibodies
I typical immune response with formation of large quantities of anti-A agglutinins
of X
G. a maximum titre of agglutinins is reached at birth loy's
H. the titre of agglutinins gradually declines throughout the remaining years of life
I. immediately after birth, the quantity of agglutinins in the plasma is almost zero
J. two to 8 months after birth, an infant begins to produce agglutinins
123. The following statements about transfusion are true:
A. the agglutinins have 10 binding sites (IgM type) Ign
=1 igG =
2
X
B. white blood cells cannot destroy the membranes of the agglutinated cells
C. when recipient and donor bloods are mismatched, immediate neutralization of RBCs
occurs
D. only chronic haemolysis occurs in transfusion reaction
d E. haemolysis is caused by physical distortion of the cells
released -
F. haemoglobin is destroyed through haemolysis
into G. the RBCs agglutinate as a result of the agglutinins attaching themselves to the RBCs,
plasma when bloods are mismatched
X
H. the agglutinins have 2 binding sites (IgM type)
I. through agglutination the cells bound together and clump
J. a single agglutinin can attach to two or more RBCs at the same time
124. The following statements about transfusion are true:
A. for lysis to occur there has to be a low titre of antibodies
Ihigh
B. haemoglobin is released into the plasma through haemolysis
19*
X
C. haemolysins are mainly IgG antibodies
2
D. the agglutinins have 10 binding sites (IgG type)
E. haemolysis is caused by the attack of phagocytic white blood cells
F. acute haemolysis occurs in some transfusion reactions
X
-
X
H. a person who has a C antigen, also has the c antigen
I. there are six common types of Rh antigens Not spontaneous
- -
LOSS
A. haemostasis is achieved by the formation of a platelet plug
B. haemostasis is achieved by the growth of fibrous tissue into the blood clot
C. haemostasis means the prevention of blood loss
D. haemostasis is achieved by chemotaxis
E. haemostasis is achieved by the formation of a blood clot
F. haemostasis is achieved by vascular constriction
-
-x
G. the normal concentration of platelets in the blood is between 15,000 and 30,000 per
microlitre Platelet X
S ~
H. local autocoid factors from the traumatized tissues cause vascular constriction -
- I. thrombocytes are minute discs 1 to 4 micrometres in diameter
smaller
J. for the larger vessels, the platelets are responsible for the vasoconstriction
-
130. The following statements about haemostasis are true: (Sticks)
A. the coat of glycoproteins on the surface of the platelet cell membrane causes
adherence to
x
adherence to normal endothelium and repulses adherence to injured areas
B. platelets are responsible for the- vasoconstriction of the smaller vessels
injured areas
X ca2t
C. the endoplasmic reticulum stores large quantities of sodium ions
x contract
-
I. the vascular spasm can last for many minutes of even hours
J. -
thromboxane A2 is a vasoconstrictor substance
131. The following statements about haemostasis are true:
A. the vascular spasm can onlyI last a few minutes -> hrs
B. the platelet plug is tight from the start
Form platelets
C. the megakaryocytes fragment into platelets especially as they squeeze through
-
capillaries
D. the normal concentration of platelets in the blood is between 150,000 and 300,000
per microlitre
E. when platelets come in contact with a damaged vascular surface, they begin to
contract
F. the Golgi apparatus from the platelet's cytoplasm stores large quantities of calcium
ions vasoconstrictor
platelewa
-
t
E. the endoplasmic reticulum stores large quantities of sodium ions cat
F. platelets have a half-life in the blood of 120 days 8 days
x
G. fibrinogen is factor I -
H. proaccelerin is factor VII -
-
-
I. calcium is factor IV
J. proconvertin is factor X X
136. The following statements about clotting factors in blood are true:
A. prekallikrein is Fletcher factor
B. plasma thromboplastin component is factor IX
C. Ac-globulin is factor VII X v -
D. stable factor is factor VII E
E. labile factor is factor V -
F. antihemophilic factor C is factor XI
-
G. calcium is factor I x
H. Stuart-Prower factor is factor II ↓
I. fibrinogen is factor XII X
J. Fitzgerald factor is factor III X
137. Among the effects of the complement system are:
0 A. the complement products cause the interstitial fluid proteins to coagulate in the
-
-
tissue spaces Direct
B. the lytic complex has an indirect effect of rupturing the cell membranes of bacteria
O
C. the complement system activates the mast cells
-
D. C3b inactivates phagocytosis Activates e
X
E. activation of the basophils does not cause inflammatory effects
0 F. through opsonization neutrophils and macrophages engulf the bacteria to which the
antigen-antibody complexes are attached
0 G. histamine and heparin, released by mast cells and basophils, cause an increased blood
leakage of fluid and plasma protein into the tissue X flow
H. the complement products cannot attack viruses, only bacteria
-
D I. through agglutination, the invading organisms adhere to one another
J. C4a causes platelets to release heparin
138. Which of the following are not effects of the complement system?
A. through agglutination, the invading organisms adhere to one another -
0
B. through opsonization, the antigen-antibody complexes are detached from the
X
bacteria X
&
IA
C. there are nine possible combinations of alleles 41
D. the blood type AB is the most frequent X
E. there are six possible combinations of alleles 9%
F. the blood type O is the most infrequent
3
G. blood type A is the most infrequent Less
H. the combinations of alleles are known as the genotypes frequent
I. the blood type O is the most frequent
J. only-one allele is present on each of the two chromosomes in any individual
145.
!
The following about the genetic determination of the agglutinogens are false:
A. the type B allele is functionless
B. the type O allele causes no significant type O agglutinogen on the cells
C. the blood type O is the most frequent
D. the blood type AB is the most frequent
E. the type B is recessive to both the O and A allele
F. the type A and B alleles cause strong agglutinogens on the cells
G. because each person has two sets of chromosomes, two types of alleles are present
on each of the chromosomes in any individual
H. the blood type O is the most infrequent
I. the combinations of alleles are known as the genotypes
J. only one allele is present on each of the two chromosomes in any individual
146. The following about the genetic determination of the agglutinogens are true:
A. a person with genotype OO produces both A and B agglutinogens
B. a person with genotype OA has blood type O
C. a person with genotype AB produces no agglutinogens
D. a person with genotype OB produces type A agglutinogens
E. a person with genotype OO produces no agglutinogens
F. a person with genotype OA produces type B agglutinogens
G. a person with genotype AA produces type A agglutinogens
H. a person with genotype BB produces type B agglutinogens
I. a person with genotype OA has blood type A
J. a person with genotype AB produces both A and B agglutinogens
147. The following about the genetic determination of the agglutinogens are true:
A. a person with genotype OA has blood type A
B. a person with genotype OA has blood type O
C. a person with genotype AA has blood type B
D. a person with genotype AB has blood type O
E. a person with genotype BB has blood type B
F. a person with genotype OO has blood type O
G. a person with genotype AA has blood type A
H. a person with genotype OO has blood type AB
I. a person with genotype AB has blood type AB
J. a person with genotype BB has blood type A
148. 0!
The following about the genetic determination of the agglutinogens are false:
A. a person with genotype AB produces both A and B agglutinogens
B. a person with genotype OA has blood type A
C. a person with genotype BB produces type B agglutinogens
D. a person with genotype AA has blood type A
E. a person with genotype AA has blood type B
F. a person with genotype BB has blood type A
G. a person with genotype OO produces no agglutinogens
H. a person with genotype OO produces both A and B agglutinogens
I. a person with genotype OA produces type B agglutinogens
J. a person with genotype AB produces no agglutinogens
149. The following statements about agglutinins are true: x Anti-A Anti-B
+
C. immediately after birth, the quantity of agglutinins in the plasma is almost zero
D. infusion of group B antigen into a recipient having a non-A blood type causes a
typical immune response with the formation of large quantities of anti-A agglutinins
E. the titre of agglutinins gradually declines throughout the remaining years of life
F. a maximum titre of agglutinins is reached at birth
G. a maximum titre is usually reached at 8 to 10 years of age
H. the agglutinins are produced only by the bone marrow #
I. the agglutinins are gamma globulins
hyrah
J. most agglutinins are IgE immunoglobulin molecules
151. 0!
The following statements about agglutinins are false:
A. when type B agglutinogen is not present in a person's RBCs, antibodies known as
anti-B agglutinins develop
B. the agglutinins are produced only by the bone marrow
C. a maximum titre of agglutinins is reached at birth
D. type O blood contains no agglutinogens, and therefore no agglutinins
E. type AB blood contains no agglutinins
F. a maximum titre is usually reached at 8 to 10 years of age
G. the titre of agglutinins gradually declines throughout the remaining years of life
H. when type B agglutinogen is present in a person's RBCs, antibodies known as anti-B
agglutinins develop
I. type O blood contains both anti-A and anti-B agglutinins
J. type A blood contains type A agglutinogens and anti-A agglutinins
152. The following statements about transfusion are true: hemolysin
- A. haemoglobin is destroyed through haemolysis 19G
nevered B. the agglutinins have 10 binding sites (IgM type) g
destroy C. haemolysis is caused by a physical distortion of the cells
I
D. white blood cells cannot destroy the membranes of the agglutinated cells I
naks into
E. only chronic haemolysis occurs in transfusion reaction
plasma F. a single agglutinin can attach to two or more RBCs at the same time
G. the RBCs agglutinate as a result of the agglutinins attaching themselves to the RBCs
when types of blood are mismatched
10
H. the agglutinins have 2 binding sites (IgM type)
-
constrictres
e I. thrombocytes are minute discs 1 to 4 micrometres in diameter
0
J. haemostasis is achieved by agglutination -is
162. The following statements about haemostasis are true:
A. the vascular spasm can last for many minutes or even hours
B. if the cut in the blood vessel is very small, the cut is often sealed by a platelet plug
C. the endoplasmic reticulum stores large quantities of sodium ca2t
X
ions
D. the coat of glycoproteins on the surface of the platelet cell membrane causes
adherence to normal endothelium and repulses adherence to injured areas
*causes -> injured
E. thromboxane A2 is a vasoconstrictor substance adherence areas
F. platelets are also called erythrocytes X
x
G. platelets have a half-life in the blood of 120 days 8 days
H. platelets are responsible for the vasoconstriction of the smaller vessels
I. thrombosthenin causes the platelets to dilate X
J. vascular constriction is obtained by nervous reflexes
163. The following statements about haemostasis are true:
A. the platelet plug is tight from the start
B. the normal concentration of platelets in the blood is between 150,000 and 300,000
per microlitre
C. the megakaryocytes fragment into platelets especially as they squeeze through
capillaries
Plateletwg
~
D. if the cut in the blood vessel is very small, the cut is often sealed by a blood clot
E. the more severely a vessel is traumatized, the greater the degree of vascular spasm
constricts
*
X
F. thromboxane A2 inactivates the nearby platelets
G. the Golgi apparatus from the platelet's cytoplasm stores large quantities of calcium
ions
H. the vascular spasm can only last a few minutes
I. when platelets come in contact with a damaged vascular surface, they begin to
contract
J. thromboxane A2 is released by platelets ~
164. The following statements about haemostasis are false: &
- A. when platelets come in contact with a damaged vascular surface, they begin to
contract
-
B. the more severely a vessel is traumatized, the greater the degree of vascular spasm
0
C. the platelet plug is tight from the start
D. platelets are also called erythrocytes
0
OE. the endoplasmic reticulum stores large quantities of sodium ions
⑧ F. the platelet plug is tight from the start A2 is released by platelets
-
G. thromboxane A2 is a vasoconstrictor substance
H. the normal concentration of platelets in the blood is between 150,000 and 300,000
~
per microlitre
-I. if the cut in the blood vessel is very small, the cut is often sealed by a platelet plug
O
J. platelets have a half-life in the blood of 120 days
165. The following statements about platelets are true: * catt
A. the endoplasmic reticulum stores large quantities of sodium ions
B. on the platelet cell membrane surface is a coat of glycoproteins that repulses
adherence to normal endothelium and yet causes adherence to injured areas of the
vessel wall
C. platelets have a half-life in the blood of 120 days
D. platelets do not have nuclei
E. platelets are also called erythrocytes
F. thrombosthenin causes the platelets to dilate
G. platelets cannot reproduce
H. the growth factor in the platelet's cytoplasm causes vascular endothelial cells to
multiply and grow
I. the platelet membrane contains large amounts of phospholipids
J. the coat of glycoproteins on the surface of the platelet cell membrane causes
adherence to normal endothelium and repulses adherence to injured areas
166. The cytoplasm of platelets contains: X
A. vacuole
B. thrombosthenin
C. actin
D. nucleus
E. myosin
F. cilium
G. residuals of endoplasmic reticulum
H. peroxisome
I. enzyme systems that synthesize prostaglandins
J. ribosomes
167. The cytoplasm of platelets contains:
A. nuclear envelope
B. chromatin
C. residuals of the Golgi apparatus
D. fibrin-stabilizing factor
E. plastid store pigments
F. growth factor
G. nuclear pore
H. enzyme systems that form ATP and ADP
I. lysosome
--DA
J. mitochondria TP
168. What does not contain the cytoplasm of platelets?
A. residuals of the Golgi apparatus -
B. lysosome
C. enzyme systems that synthesize prostaglandins 2
D. myosin W
v
E. actin
F. peroxisome
G. nucleus
H. ribosomes
I. mitochondria ~
J. nuclear pore
169. The following statements about clotting factors in the blood are true:
A. Stuart factor is the factor I X
=Fibrinogen
Prothrombin
0B. tissue factor is factor III 11
=
I
C. Christmas factor is factor V
⑧ D. calcium is factor IV 4 Calcium
=
- eree
①F. the labile factor is factor V
0G. the stable factor is factor VII
H. antihemophilic factor C is factor XI
I. Fitzgerald factor is factor III X
-
OJ. prekallikrein is Fletcher factor =1-2 mins
171. The following statements about blood coagulation in the ruptured vessel are
true: mins Trauma, 1-2mins for
=20
A. within 3 to 6 minutes after the rupture of a vessel, the clot retracts
B. once a blood clot has formed it can only be dissolvedx + Fibroblast
C. in case of severe trauma to the vascular wall, the clot beings to develop in 1 to 2
x
15-205
minutes
D. the blood clot can become invaded by fibroblasts blood
E. there are- thirteen principal clotting factors Prevents
10SS
-
J. activator substances from the traumatized vascular wall initiate the clotting process
172. The following statements about blood coagulation in the ruptured vessel are
true: 13
A. there are only seven principal clotting factors X
B. once a blood clot has formed, it cannot dissolve X
C. in case of minor trauma to the vascular wall, the clot begins to develop in 1 to 2
minutes
-
D. platelets play an important role in the clot retraction
E. the invasion of the clot by the fibroblasts is inhibited by the growth factor secreted
-x
by macrophages
F. the process of the complete organization of the clot into fibrous tissue takes about 1
to 2 hours X
G. prekallikrein is not a clotting factor X
H. activator substances from blood proteins adhering to the traumatized vascular wall
initiate the clotting process
I. in case of severe trauma to the vascular wall, the clot beings to develop in 15 to 20
seconds
J. within#3 to 6 minutes after the rupture of a vessel, the entire opening or broken end
of the vessel is filled with clot zu
173. The following statements about blood coagulation in the ruptured vessel are
0 false:
A. there are thirteen principal clotting factors
e
B. in case of minor trauma to the vascular wall, the clot begins to develop in 1 to 2
minutes ~ -
&
C. platelets play no role in the clot retraction - -D
-S
D. the formation of the blood clot is a mechanism for haemostasis
E. the process of the complete organization of the clot into fibrous tissue takes about 1
to 2 hours
F. within 3 to 6 minutes after the rupture of a vessel, the clot-retracts
dosen't
retract.
G. once a blood clot has formed it can only be dissolved
H. there are only seven principal clotting factors
I. once a blood clot has formed, it can follow one of two courses
J. in case of severe trauma to the vascular wall, the clot beings to develop in 15 to 20
seconds
174. The following statements about the mechanism of blood coagulation are true:
A. blood coagulation depends only on the anticoagulants x coagulants
+
B. the result of the coagulation cascade is the formation of the prothrombin activator
3
1) Complex
AC. blood clotting takes place in three essential steps
cascade of D. anticoagulants promote coagulation x stop coagulation
Fibrin Factors
x
Chemical E. fibrinogen enmeshes platelets, blood cells and plasma to form the clot
reactions F. much of the prothrombin first attaches to prothrombin receptors on the platelets
Prothrombin
=>
Splits
↓
Thrombin
-
33,700
J. anticoagulants inhibit coagulation
176. The following statements about the mechanism of blood coagulation are& false:
A. the result of the coagulation cascade is the formation of the prothrombin inhibitor
B. fibrinogen enmeshes platelets, blood cells and plasma to form the clot
C. in response to the rupture of the vessel or damage to the blood itself, a complex
cascade of chemical reactions occurs in the blood involving more than a dozen blood
coagulation factors
D. anticoagulants promote coagulation
E. blood clotting takes place in three essential steps W
X
Fibrinogen
->
s
F. thrombin acts as an enzyme to convert fibrin fibres into fibrinogen
-
F. -
vitamin K is required by the liver for normal activation of prothrombin
G. the prothrombin activator in presence of sufficient amounts of ionic calcium causes
the conversion of prothrombin to thrombin
H. blood coagulation depends only on procoagulants X
I. the anticoagulants normally do not circulate in the blood vessels X
J. procoagulants inhibit coagulation X
178. The following statements about the mechanism of blood coagulation are true:
A. in the bloodstream, anticoagulants normally predominate
B. prothrombin has a molecular weight of 68,700
C. thrombin is a protein enzyme with strong proteolytic capabilities
D. procoagulants promote coagulation
E. fibrinogen formed in the spleen Lever
is essential for clot formation
F. the prothrombin activator is formed as a result of damage to special substances in
the blood
-
182.
⑧
J. prothrombin is present in normal plasma in a concentration of about 15mg/dl
The following statements about the mechanism of blood coagulation are false:
A. prothrombin is a stable protein
B. fibrinogen is a low-molecular-weight protein
C. the prothrombin activator is formed as a result of the rupture of a blood vessel
D. platelets have no role in the conversion of prothrombin to thrombin
E. the lack of vitamin K leads to a bleeding tendency
F. platelets play an important role in the conversion of prothrombin to thrombin
G. vitamin A is required by the liver for normal activation of prothrombin
H. one molecule of fibrin monomer has the automatic capability to polymerize with
other fibrin monomer molecules to form fibrin fibres
I. thrombin causes the polymerization of fibrinogen molecules into fibrin fibres within
10 to 15 minutes
J. fibrinogen formed in the liver is essential for clot formation
183. The following statements about the mechanism of blood coagulation are true:
continuously.
A. prothrombin is formed discontinuously by the liver
B. in the early stages of polymerization, the fibrin monomer molecules are held
together by weak noncovalent hydrogen bonding amounts
x small
C. the fibrin-stabilizing factor is present in large amounts in normal plasma globulins
D. prothrombin is an unstable protein
E. prothrombin concentration in the plasma falls too low to provide normal blood
coagulation if the liver fails to produce prothrombin for one month I day
-
E. prothrombin is continually being used throughout the body for blood clotting
F. in the early stages of polymerization, the resultant clot is weak and can be broken
~
apart with ease
y large
G. because of its small molecular size, fibrinogen normally does not leak from the blood
vessels into the interstitial fluids
⑧x
H. in the plasma, fibrinogen is found in quantities of 100 to 700 mg/dl
I. thrombin has almost exactly twice the molecular weight of the prothrombin minutes
x
J. the clot begins to contract and usually expresses most of the fluid from it in 20 to 60
hours
185. The following statements about the mechanism of blood coagulation are false:
A. prothrombin is formed discontinuously by the liver state.
B. the lack of vitamin K leads to a procoagulant status X => Anticoagulant
C. because of its large molecular size, little fibrinogen normally leaks from the blood
~
vessels into the interstitial fluids
D. the fibrin-stabilizing factor is not present in normal plasma globulins
E. prothrombin is an unstable protein
estable A
F. the clot begins to contract and usually expresses most of the fluid from it in 20 to 60
hours minutes'
G. interstitial fluids ordinarily do not coagulate W
H. prothrombin is continually being used throughout the body for blood clotting -
I. in the early stages of polymerization, the resultant clot is weak and can be broken
clotting
~
apart with ease
↑Feedback more
=
The following statements about the mechanism of blood coagulation are true: crotting
C
A. the fibrin-stabilizing factor is present in small amounts in normal plasma globulins
⑰
B. the clot initiates negative feedback to inhibit more clotting T
C. a failure of clot retraction is an indication that the number of platelets in the
circulating blood might be high- Low
xClot retraction
D. platelets are necessary for clot retraction to occur
E. the fibrin-stabilizing factor exerts its effect only when it is activated
- I platelets
X
F. platelets entrapped in the clot will not release any more procoagulant substances
G. the clot begins to contract and usually expresses most of the fluid from it in 20 to 60
minutes weak
T
H. from the early stages of polymerization, the resultant clot is strong and cannot be
broken apart
I. thrombin activates the fibrin-stabilizing factor myosint contraction
actin=>
J. platelets inactivate actin molecules activate
-
187. The following statements about the mechanism of blood coagulation are true:
A. the serum can clot - > no clotting factors
-
J. platelets entrapped in the clot will not release any more procoagulant substances
189. The following statements about the mechanism of blood coagulation are true:
A. the fibrin-stabilizing factor is also released from platelets entrapped in the clot
- -
the fibrin fibres in such a way that they actually bond different fibres together
-
trauma platelet
er thrombin Activates
Conag Activates myosin
- D Platelet
B. the intrinsic pathway of coagulation begins with trauma to the vascular wall and
surroundings tissues xextrinsic
C. blood-clotting factors do not play a role in the intrinsic pathway, only in the extrinsic
X
one
D. the fibrin-stabilizing factor causes more and more cross-linking bonds between
③
adjacent fibrin fibres
E. the contraction of the platelets is activated by thrombin 24
F. in the presence of sodium, prothrombin is split to form thrombinxCa
G. platelets entrapped in the clot continue to release procoagulant substances
0
H. platelets inactivate the platelet thrombosthenin
I. platelets activate myosin molecules
⑧
J. the inactivated factor VII combined with factor II form the complex called
prothrombin activator
191. The following statements about the mechanism of blood coagulation are false:
A. in the presence of sodium, prothrombin is split to form thrombin -
0
platclets I
-
193. The following statements about the mechanism of blood coagulation are true:
A. most of the blood-clotting factors are inactive forms of proteolytic enzymes
B. the intrinsic pathway can be explosive-
cat
x
C. in the absence of sodium ions, blood clotting by either pathway does not occur I
D. factor X is called the antihemophilic factor x VIII
E. tissue thromboplastin is - released by traumatized tissue
F. clotting does not occur by both pathways simultaneously -
G. the extrinsic pathway of coagulation begins with trauma to the vascular wall and
surrounding tissue
xcat no
=
pathway
H. as the clot retracts, the edges of the broken blood vessel are pulled together, thus
contributing still further to haemostasis
I. one of the most important factors for preventing clotting in the normal vascular
system is the roughness of the endothelial cell surface
J. the contraction of the platelets is activated by calcium ions released from calcium
stores in the mitochondria
194. The following statements about the mechanism of blood coagulation are false:
A. clotting does not occur by both pathways simultaneously
B. factor X is called antihemophilic factor - VIII
C. in a person with classic haemophilia factor XII is missing
D. one of the most important factors for preventing clotting in the normal vascular
system is the roughness of the endothelial cell surface
E. prothrombin activator is formed in two ways
F. in thrombocytosis platelets are the clotting factor that is lacking
G. blood-clotting factors play a major role in both the extrinsic and the intrinsic
pathways
H. the contraction of the platelets is activated by calcium ions released from calcium
stores in the mitochondria
I. the contraction of the platelets is accelerated by thrombin
J. tissue thromboplastin is released by traumatized tissue
195. The following statements about the mechanism of blood coagulation are true:
A. the binding of thrombin with thrombomodulin accelerates the clotting process
B. the activation of factor XI requirese high-molecular-weight kininogen cotting
C. platelet factor 3 plays a role in subsequent clotting reactions factors - A
creight
D. contact of factor XII and platelets with collagen in the vascular wall initiates the
extrinsic pathway X
E. blood trauma causes the release of platelet phospholipids
Quicker.
F. the extrinsic pathway is much slower than the intrinsic one x
-
Activates
- H. tissue factor initiates the intrinsic pathway Extrinsic extrinsic
1-6 mins
-
x
plasmin
x
F. plasminogen causes the lysis of clots X
G. protein C is inactivated by the thrombomodulin-thrombin complex -
H. in the absence of calcium ions, blood clotting by either pathway does not occur
I. antithrombin III is a procoagulant X
J. clotting occurs by both pathways simultaneously
197. The following statements about the mechanism of blood coagulation are false:
A. the extrinsic pathway is much slower than the intrinsic one
B. blood trauma causes the release of platelet phospholipids
C. the extrinsic pathway requires 1 to 6 minutes to cause clotting
D. plasminogen causes the lysis of clots
~
plasmin
E. in the absence of calcium ions blood clotting by either pathway does not occur
F. factor VIII is called antihemophilic factor
G. platelet factor 3 plays a role in subsequent clotting reactions
H. clotting occurs by both pathways simultaneously
I. through the intrinsic pathway clotting can occur in as little as 15 seconds
J. tissue factor initiates the intrinsic pathway
198. The following statements about the mechanism of blood coagulation are true:
A. through the extrinsic pathway clotting can occur in as little as 15 seconds
B. the intrinsic pathway is much slower than the extrinsic one
C. protein C acts as a procoagulant X
D.
-
contact of- factor XII and platelets with collagen in the vascular wall initiates the
intrinsic pathway
E. Anticoagulant
-
heparin is a powerful procoagulant
F. protein C activates factor V and VIII X
G. the extrinsic pathway can be explosive -
plasminogen Yasmin
H. the tissue plasminogen activator converts plasmin into plasminogen in order to
remove the unnecessary blood clot -
I. the intrinsic pathway requires 1 to 6 minutes to cause clotting
J. heparin is produced in large quantities by erythrocytes ↑ basophilic mast cell
199. The following statements about the mechanism of blood coagulation are true:
NO
A. heparin, by itself, has- anticoagulant properties, but combined with antithrombin III
7 Thrombin III
has little or no anticoagulant properties
B. among the most important anticoagulants in the blood are the fibrin fibres and
antithrombin-heparin cofactor
- -
C. one of the most important factors for preventing clotting in the normal vascular
system is the smoothness of the endothelial cell surface -
X Activator
D. the result of the coagulation cascade is the formation of the prothrombin inhibitor
E. the binding of thrombin with thrombomodulin slows the clotting process -
E-
F. protein C acts as an anticoagulant by inactivating activate factors V and VIII
G. the concentration of heparin in the blood is normally very high X
H. platelets are not necessary for clot retraction to occur -
I. the lack of vitamin K leads to a procoagulant status -
J. the tissue plasminogen activator converts plasminogen to plasmin
200. ⑧
The following statements about the mechanism of blood coagulation are false:
A. among the most important anticoagulants in the blood are the fibrin fibres and
antithrombin-heparin cofactor ~
B. protein C activates factor V and VIII x inactivates
C. the binding of thrombin with thrombomodulin slows the clotting process
D. heparin, by itself has anticoagulant properties, but combined with antithrombin III
has little or no anticoagulant properties Thrombin
↓
stimulatory effect
H. interleukin-2 has an especially strong inhibitory effect in causing the growth and
proliferation of both cytotoxic and suppressor T cells
T
HIV inactivates
Helper I. T cells are classified into three major groups
-
T-helper cells
J. lymphokines are formed by cytotoxic T cells
cells 203. The following statements about the T cells are true:
A. in the absence of the lymphokines from the T-helper cells, the remainder of the
- -
D. two major lineages of WBCs are formed, the myelocytic and the lymphocytic lineages
E. the immune system of the body develops antibodies against infectious agents
F. lymphocytes are formed both in the bone marrow and in the lymph tissue
G. eosinophils are a type of WBCs
H. 62.0 per cent of the total WBCs is represented by basophils X
I. lymphocytes have life spans of a few hours I
J. there are more WBCs in the blood than RBCs X
208. The following statements about inflammation are true: Dilatio
x
A. inflammation is characterized by vasoconstriction of the local blood vessels letting
B. histamine is involved in the inflammation process 500f
G. only covalent bonds hold the light and heavy chains together x hytrophic...
H. IgG is involved in allergy -
I. the -variable portion is different for each specific antibody
J. the complement system has multiple means of its own for destroying the invader
> agent
211. The physiologic anatomy of the gastrointestinal wall:
X outward
A. includes the following layers from inward to the outer surface: the serosa, a
longitudinal smooth muscle layer, a circular smooth muscle layer, the submucosa,
and the mucosa
x 100S2
B. each bundle of smooth muscle fibres is partly separated from the next by tight
connective tissue I
C. includes the following layers from the°- outer surface inward: the serosa, a longitudinal
smooth muscle layer, a circular smooth muscle layer, the submucosa, and the
mucosa
D. the smooth mucosal muscle lies in the deeper layers of the mucosa the intestine
down
E. in the longitudinal muscle layer, the bundles extend around the intestinal tract -
I
A. the slow waves are undulating changes in the resting membrane potential
Calcium B. the smooth muscle of the gastrointestinal tract is excited by almost continual rapid,
by t
extrinsic electrical activity X
Ca Na C. slow waves and spikes are the two basic types of electrical waves
Channels D.
channels
o
the interstitial cells of Cajal do not undergo cyclic changes due to unique ion
undergo
X not by themselves
E. the slow waves always cause by themselves muscle contraction
F. the movement of calcium ions to the interior of the muscle fibres during the action
e -
G. the slower the slow wave potential rises, the greater the frequency of the spike
potential is
-
H. the smooth muscle of the gastrointestinal tract is excited by almost continual slow,
-
-
I. the interstitial cells of Cajal are the electrical pacemakers for smooth muscle cells
spike
x
-
membra
J. the slow waves are action potentialsx Slow
changes in resting - ne
213. The electrical activity of gastrointestinal smooth muscle: potential
A. during hyperpolarization, the fibres become less excitable
-
muscle
- -
B. the muscle fibres become less excitable when the potential becomes less negative
Less C. during=@°
-USS z
depolarization, the potential becomes more negative
paras
↓
-More D. the stimulation of the sympathetic nerves makes the muscle fibres more excitable
E. the slow waves cause calcium ions to enter the smooth muscle fibre
negative F. stimulation by acetylcholine released from the endings of parasympathetic nerves
-
makes the membrane more excitable -
parasympath
-
etil
G.
H.
then tonicecontraction
e
of the smooth muscle is continuous
---
the resting membrane potential averages about −56 millivolts
50t0
- 60 m
=
444 I. the effect of norepinephrine or epinephrine on the fibre membrane makes the
more
excitable muscle fibres more excitable x Less excitable potential=
J. the continuous entry of calcium-
negative
ions into the interior of the cell causes a tonic
contraction enteric system Icontinuous
214. Neural control of gastrointestinal function: nervous
X
A. the outer plexus lies in the submucosa Inner
-
plexus
entert
auterAverb
-
B. the myenteric plexus is the inner plexus situated between the longitudinal and
uter
circular muscle layers x
or C. the enteric nervous system begins in the esophagus and extends to the anus
inner D. the two plexuses of the enteric nervous system are: the inner plexus or Auerbach
usoh plexus, and the outer plexus or Meissner plexus myentric
X
sub
I E. the sensory nerve endings send afferent fibres to the prevertebral ganglia of the
G. the gastrointestinal tract does not have a nervous system of its own X
- transmitters
C. the myenteric plexus is entirely excitatory has inhibitory
D. acetylcholine often excites gastrointestinal activity
E. the myenteric plexus consists mostly of a linear chain of many interconnecting
-DNOneurons T excitatory
F. stimulating the myenteric plexus leads to a decreased velocity of conduction of
excitatory waves along the gut wall inhibits
Non-atrending ->
G. norepinephrine almost always excites gastrointestinal activity-
-excites
H. acetylcholine often inhibits the gastrointestinal activity X
I. stimulating the myenteric plexus increases -
-
tonic contraction continuous
J. the submucosal plexus controls local intestinal secretion, absorption and contraction
*
inner
larger of the submucosal muscle
216. Autonomic control of the gastrointestinal tract: Paraenteric
A. strong stimulation of the parasympathetic system can block the movement of food
Parasympatheticthrough the gastrointestinal tract
- -
X
=Rest digest X All
B. the cranial parasympathetic nerve fibres are almost never in the vagus nerves
Sympathetic C. parasympathetic stimulation increases the activity of the enteric nervous system
D. the stimulation of the sympathetic nervous system increases the activity of the
-
D. secretin was the first gastrointestinal hormone discovered and is secreted by the “S”
cells in the mucosa of the duodenum
E. the gastric inhibitory peptide is also known as the glucose-dependent insulinotropic
were
e
-
peptide Stimulates
I
F. the gastrin inhibits the gastric acid secretion
G. cholecystokinin contracts the gallbladder, expelling bile into the small intestine
- functions
H. the only known function of motilin is to decrease gastrointestinal motility 2 stimulates
-
I. gastrin is secreted by the “G” cells of the antrum of the stomach in response to
stimuli associated with the ingestion of a meal A
J. gastric inhibitory peptide (GIP) is secreted by the mucosa of the stomach
219. Functional types of movements in the gastrointestinal tract: Gl tract
-
A. mixing movements differ in different parts of the alimentary tract
-
xneeds -
decreased
E. peristalsis is greatly increased when a person is treated with atropine
--
F. the ”law of the gut” is composed of the peristaltic reflex plus the orad direction of
movement of the peristalsis
-
G. peristalsis, theoretically, can occur in either direction from a stimulated point, but it
normally dies out rapidly in the orad direction X
in the It
X does
H. peristalsis does not occur bile or glandular ducts
-
I. the usual stimulus for intestinal peristalsis is distention of the gut
J. propulsive and mixing movements are the two types of movements in the
gastrointestinal tract
220. The following statements about gastrointestinal blood flow are true:
A. several vasoconstrictors such as cholecystokinin, vasoactive intestinal peptide, and
gastrin are possible causes of the increased blood flow during gastrointestinal
activity -
B. kallidin and bradykinin, two powerful vasodilators, cause increased mucosal
-
vasodilatation
↓O2
C. in haemorrhagic shock or other states of low blood volume, sympathetic stimulation
can provide as much as 200 to 400 millilitres of extra blood to sustain the general
circulation
-
D. the blood vessels of the gastrointestinal system are part of the splanchnic circulation
X
E. sympathetic stimulation causes intense vasoconstriction of the arterioles with
increased blood flow
F. the non-fat, water-soluble nutrients absorbed from the intestinal tract are absorbed
into the intestinal lymphatics and then conducted to the systemic circulating blood
through the thoracic duct X
OPPOSite
G. the arterial flow into the villus and the venous flow out of the villus are in the same
direction X
X
H. increased oxygen concentration in the gut wall can increase intestinal blood flow
I. the arterial flow into the villus and the venous flow out of the villus are in directions
opposite to each other
- Aterzer vein or
J. during active absorption of nutrients, blood flow in the villi, the submucosa and the
muscle layers is increased
221. The following about mastication and swallowing are true:
A. the chewing process is caused by a chewing reflex and a rebound contraction
B. as the bolus of food enters the posterior mouth and pharynx, it stimulates epithelial
swallowing receptor areas all around the opening of the pharynx
C. digestive enzymes act only on the surfaces of food particles xstriated
D. the musculature of the pharyngeal wall and upper third of the esophagus is smooth
muscle X 10820
E. the esophagus normally exhibits three types of peristaltic movements: primary
-
e B. the hunger pangs are the mild pain in the pit of the stomach experienced when
hunger contractions occur
-
healthy makes
x
C. hunger contractions are more intense in the elderly, sick individuals
D. gastrin inhibits stomach emptying
-
X
E. the thickness of the circular wall muscle of the pylorus is 50 to 100 per cent greater
-
-
than in the earlier portions of the stomach antrum
F. hypotonic and hypertonic fluids elicit the inhibitory reflexes
-
antrum
->
I. stretching of the stomach wall accentuates the activity of the pyloric pump and
inhibits theActivates
A
pylorus 7 12-1445s
J. hunger pangs usually begin 2 to 4 hours after the last ingestion of food
224. Movements of the small intestine: I
A. propulsive contractions are also known as segmentation contractions
B. the peristaltic waves move towards the anus at a velocity of 0.5 to 2.0 cm/sec
C. the net movement of the chyme along the small intestine averages only 1cm/min
D. are divided into mixing contractions and propulsive contractions
- -
Stomach
E. the chyme is sometimes blocked for several hours until the person eats another meal
F. the peristaltic waves move slower in the proximal intestine and faster in the terminal
X
intestine inhibit
-
G. secretin and glucagon stimulate small intestinal motility
-
H. 3 to 5 hours are required for the passage of chyme from the pylorus to the ileocecal
valve
- -
B. the proximal half of the colon is concerned with absorption, and the distal half is with
storage
C. excess motility in the colon causes greater absorption and poor motility causes less
absorption
D. the gastrocolic and duodenocolic reflexes inhibit the appearance of mass movements
E. the colon has two principal functions: absorption and storage irritation
by
F. a series of mass movements usually persists for - 10 to 30 minutes
-
↑Longitudinal
G. the circular muscle of the colon is aggregated into three circular strips called the
Aoueirritation
teniae coli
H. the propulsive movements are also known as haustrations ->
I. a person with ulcerative colitis does not experience mass movements
J. there are required 8 to 15 hours to move the chyme from the ileocecal valve through
the colon
226.
-
The following statements about defecation are true:
A. defecation signals initiate effects such as taking a deep breath and closure of the
glottis
abdominalele
B. defecation signals cause the pelvic floor to contract in order to evaginate the faeces
C. the external anal sphincter is composed of a smooth involuntary muscle that
- >
external sphincter
agusnerve pudendal
↑ I
F. the external sphincter is controlled by nerve fibres in the vagus nerve
G. the internal anal sphincter is a thickening of the circular striated muscle that lies
I
J. in the defecation process, the rectum is relaxed and the anal sphincters are
contracted
227. Which of the following arene alimentary tract glands?
A. Henle's glands ↳in stomach lining
B. oxyntic glands 4) Make stomach acids
C. pineal gland -
D. goblet cells-
E. adrenal gland
F. Lumbar glands
G. mucous cells
H. crypts of Lieberkühn
I. pancreas
ancreas
4
J. Krause's glands -
2.
228. Types of alimentary tract glands: -
A. the crypts of Lieberkühn extrude mucus directly onto the epithelial surface
B. the mucus secreted by the mucous cells protects the surfaces from excoriation and
Pecting
↳
digestion off
C. the pits are invaginations of the epithelium into the submucosa
D. an acid and pepsinogen-secreting gland of the stomach is a tubular gland
-
stard-- starches
x
D. ptyalin is an enzyme for digesting proteins
44
Large
E. saliva contains low X
quantities of potassium and bicarbonate ions X
F. the acini secrete a primary secretion that contains ptyalin and/or mucin
-
H. the parotid, submandibular and sublingual glands are the principal glands of
-
salivation
I. the concentrations of both sodium and chloride ions are several times less in saliva
than in plasma ↓Natc in saliva
J. the submandibular gland contains acini and salivary ducts - blood
me than
230. The following about saliva are true:
A. thiocyanate and lysozyme are two factors in saliva that destroy bacteria Act
0 4
B. the sour taste elicits copious secretion of saliva
-ENTRAL
I
-
activates
-
proteins
I down. pepticl ->
pepsinogen
A. acetylcholine inhibits the secretion of pepsinogen by peptic cells Chief
-
-
G. the parietal cells secrete an acid solution, which is nearly isotonic with the body fluids
H. an oxyntic cell contains large branching intracellular canaliculi
I. gastrin stimulates the secretion of acid by parietal cells
J. the hydrochloric acid has a 0,8 pH pepsin
↳
e
232. The following statements about gastric secretion are true: I
A. pepsinogen in contact with hydrochloric acid forms active pepsin HCL
pepsinogen
B. the H⁺ is passively secreted into the canaliculus, a passive process catalysed by H⁺ -
K⁺ATP ase X
C. the final secretion from the canaliculus contains water, hydrochloric acid, potassium
chloride and sodium chloride
D. aspirin is a drug used to reinforce the gastric barrier X
E. the basolateral Na⁺- K⁺ATPase creates high intracellular Na⁺, which contributes to Na⁺
reabsorption from the lumen of the canaliculus X
F. pepsin has the most proteolytic activity at a pH above 5 I
G. the pumping of H⁺ out of the cell by the H⁺-K⁺ ATPase permits OH⁻ to accumulate
and form bicarbonate from CO2 -Cz
H. the water inside the parietal cell becomes dissociated into H⁺ and OH⁻ in the cell
cytoplasm -
* digestive
G. ~
the intrinsic factor is secreted by the parietal cells
H. above a pH of 5 pepsin has almost no proteolytic activity
I. the mucus secreted by the surface mucous cells is alkaline
J. In pernicious anaemia, in the absence of vitamin B12 red blood cells fail to mature
234. The following statements about gastric secretion are true:
A. the stomach secretes a few millilitres
-
of gastric juice each hour during the
“interdigestive period”
B. the reverse enterogastric reflex transmitted through the myenteric nervous system
cell-causedsight
stimulates stomach secretion
C. the gastric secretion is said to occur in four phases
D. histamine is secreted by GX cellsmast
E. neurogenic signals that cause the cephalic phase of gastric secretion - originate in the
=
cerebral cortex and the appetite centres of the amygdala and hypothalamus.
-
H. the cephalic phase accounts for 60 per cent of the gastric secretion associated with
x
eating a meal 30%
I. the gastric phase accounts for about 60 per cent of the total gastric secretion
associated with eating a meal cephalic phast
X
J. the intestinal phase accounts for about 30 per cent of the acid response to a meal
10 %
235. Pancreatic secretion:
A. in cases of large quantities of pancreatic juice, the bicarbonate ion concentration
lowers to 15 mEq/L x ~carbs
B. pancreatic amylase is the pancreatic enzyme for digesting proteins
C. trypsinogen is activated by- enterokinase
- lipase: fat
D. pancreatic lipase is responsible for fat digestion
x-
proteins
E. trypsin also hydrolyses starches, glycogen and most carbohydrates
F. in acute pancreatitis, the effect of trypsin inhibitor is overwhelmed
G. pancreatic juice is secreted most abundantly in response to the presence of chyme in
the upper portions of the small intestine -
H. trypsin and chymotrypsin split whole and partially digested proteins into peptides
and individual - amino acids Not a
I. the most important of the pancreatic enzymes for digesting proteins are trypsin,
chymotrypsin, and carboxypolypeptidase
J. when first synthesized in the pancreatic cells, the proteolytic digestive enzymes are in
their enzymatically active forms, and then they become inactiveI always inactive
236. The following statements about pancreatic secretion are true:
A. after chyme leaves the stomach and enters the small intestine, pancreatic secretion
decreases, mainly in response to gastrin X less acidic
B. secretin is a polypeptide containing- 27 amino acids
C. acetylcholine stimulates the production of large quantities of pancreatic digestive
D.
enzymes parasympathetic
acetylcholine is released from the sympathetic hypoglossal nerve endings
E. cholecystokinin is secreted by the duodenal and upper jejunal mucosa
-
F. prosecretin is activated in secretin when chyme with a pH less than 4.5 to 5.0 enters
-
the duodenum -
bicarbonate.
X
G. secretin stimulates the production of large quantities of pancreatic digestive
enzymes Secretio
~
H. cholecystokinin stimulates the secretion of large quantities of water solution of
sodium bicarbonate
⑧
I. the cephalic phase accounts for about 20 per cent of the total secretion of pancreatic
enzymes after a meal
X 3-cephalic gastric
-
F. secretin begins to be released from the mucosa of the small intestine when the pH of
the duodenal contents is above 6.0 + 3
G. the release of cholecystokinin results especially from the presence of amylase
H.Xcholecystokinin causes sodium bicarbonate secretion
I. cholecystokinin is a polypeptide containing 33 amino acids
33
50"
J. cholecystokinin accounts for-- 70 to 80 per cent of the total secretion of the pancreatic
digestive enzymes after a meal
238. Bile secretion by the liver:
A. bile is secreted in two stages by the liver
B. the bile serves as means for the excretion of waste products from the blood
C. cholecystokinin causes gallbladder dilatation in order to store bile
X
D. the second secretion of bile is inhibited by secretin
E. bile plays an important role inXprotein digestion
F. the initial portion of bile is secreted by the hepatocytes Liver
-
X
G. bilirubin is an end product of platelet destruction
H. cholecystokinin causes contraction of the sphincter of Oddi
2nd time 10
=
Absorbed
J. the maximum volume that the gallbladder can hold is 30 to 60 millilitres
240. The following statements about bile secretion are true:
A. micelles are entirely insoluble in the chyme Semi-solubles
B. about 94 per cent of the bile salts are reabsorbed into the blood from the small
intestine
-
D C. bile salts have detergent action on the fat particles in the food
D. the concentration of potassium in the liver bile is 5 mEq/L and in the gallbladder bile
is 12 mEq/L
E. the bile salts are recirculated into the bile, so on average these salts make the entire
-
circuit even 17 times before being carried out in the faeces
-
CCK
1 -
I. when significant quantities of fat are present, the gallbladder normally empties in
-
about 1 hour
J. the reabsorption of the bile salts occurs only by diffusion X Active transpor
241. Brunner’s glands and Lieberkühn crypts: protects duodenal wal
Alkali
-
acidiqnices
B. the primary function of the small intestine is to absorb nutrients and their digestive
products into the blood
Activates
C. vagal stimulation inhibits Brunner gland secretion
-
D. the crypts of Lieberkühn are located over the entire surface of the small intestine
water
E. the enterocytes secrete mucus that lubricates and protects the intestinal surfaces
+muws
F. the goblet cells secrete water and electrolytes
-- - inhibited.
G. Brunner’s glands are stimulated by sympathetic stimulation small
*
H. Brunner’s glands are located in the wall of the last centimetres of the ileum intestine
I. the intestinal secretion has a pH in the range of- 7.5 to 8.0
J. the mucus secreted by Brunner’s glands contains a large excess of bicarbonate ions
242. Which of the following are digestive enzymes that digest specific food
substances?
A. lactase
B. lipase L
C. amylase X
-
X for food.
D. maltase -
E. acetylcholinesterase X
F. sucrase
G. pepsin x
H. isomaltase
I. helicase X
J. trypsin 7
243. Secretion of the large intestine:
A. the mucus in the large intestine protects the intestinal wall against excoriation
digestive enzymes
B. the epithelialtwo
cells secrete large quantities of digestive enzymes
C. the mucus in the large intestine provides an adherent medium for holding faecal
matter together
D. the mucosa of the large intestine has, like the small intestine, many crypts of
Lieberkühn parasympathetic
->
D. triglycerides are combinations of three fatty acid molecules condensed with a single
glycerol molecule -
I I
A. sucrose is a large polysaccharide present in almost all non-animal foods, particularly
in potatoes and grains D
cand xnot
B. enzymes capable of hydrolyzing cellulose are secreted in the human digestive tract
sug -
C. starches are the disaccharides known popularly as cane sugar
D. pancreatic secretion contains a large quantity of- α-amylase tyclin-ba-
E. saliva contains the digestive enzyme ptyalin amylase
z
F. over 50% of all the starches will have been hydrolyzed by the time the food is
swallowed 30-40
G. amylase is inactive at a pH below 4.0
Lactose,
H. lactose is a disaccharide found in milk Sucrose, starch-
I. the only three major sources of carbohydrates in the normal human diet are:
amylose, glycogen and dextrins X
J. ptyalin hydrolyzes starch into maltose
246. Which of the following are carbohydrates?
A. ptyalin X
B. alcohol
C. lecithin
D. pepsin X
E. tristearin
F. dextrins
G. pyruvic acid
lactose ->
galactose + Glcost
sucrose ->
fructure +Glucose
H. pectins
I. elastase
Maltose -> xxx
glucose.....
J. lactic acid
247. The following statements about carbohydrates digestion are true:
maltose-D
-
A. lactase, sucrase and maltase are examples of disaccharides
B. the monosaccharides are insoluble in water
-
C. in the ordinary diet, glucose represents more than 80 per cent of the final products
of carbohydrate digestion
X
D. sucrose splits into a molecule of galactose and a molecule of glucose
E. galactose and fructose represent each 10 per cent of the final products of
- -
carbohydrate digestion
F. carbohydrates are almost entirely converted into maltose and/or other small glucose
polymers before passing beyond the duodenum
G. the enterocytes lining the villi of the small intestine contain four enzymes capable of
splitting the disaccharides into monosaccharides
H. lactose, sucrose, maltose and small glucose polymer are the four enzymes of the
b
enterocytes splitting disaccharides into monosaccharides ~- 44s-
I. the pancreatic α-amylase is several times more powerful than the saliva α-amylase
J. maltose splits into a molecule of fructose and a molecule of galactose x
glucose
248. Digestion of proteins:
A. collagen is digested by pepsin 20
B. pepsin provides over 50% of the total protein digestion
A
G. emulsification of the fat begins by agitation in the stomach to mix the fat with the
product of stomach digestion
H. triglycerides are composed of a glycerol nucleus and three fatty acid side chains
-
I. enteric lipase is by far the most important enzyme for digestion of the triglycerides -
-
J. the polar parts of the bile salts and lecithin molecules are insoluble in water X
-
250. The following statements about gastrointestinal absorption are true:
I
no villi
A. the stomach is a high-absorptive area of the gastrointestinal tract
B. the central lacteal lymph vessel is present in the valvulae connivents
C. the folds of Kerckring can protrude up to 8 millimetres into the lumen
D. the pinocytic vesicles are portions of infolded enterocyte membrane
- -
E. the brush border consists of 1000 microvilli that protrude into the intestinal chyme
-
F. the folds of Kerckring, the villi and microvilli increase the total absorptive area of the
X
mucosa 10-fold 1000 x X
vicli
G. on the epithelial surface of the small intestine are present millions of villi
-
H. the folds of Kerckring increase the surface area of the absorptive mucosa about
threefold
I. valvulae connivents are present on the surface of the stomach mucosa
I
J. from the epithelial cell body into each microvillus are multiple myosin filaments
251. The following statements about gastrointestinal absorption are true:
A. in the transcellular pathway, osmosis occurs through the tight junctions between the
apical borders of the epithelial cells
* *dehydration.
B. in hyperhydration, large amounts of aldosterone are secreted
C. the osmosis of water involves two pathways Na
D. sodium concentration of the chyme is about 142 mEq/L
-
F. sodium is transported passively from the inside of the epithelial cells into paracellular
spaces *
Actively
X
G. sodium helps absorb sugars and amino acids I
H. the intestines absorb less than 5 grams of sodium each day
absorbtion
I.
J.
aldosterone is secreted by the cortices of the adrenal
->
*Na
glands
the large intestine absorbs more nutrients than water and ions
252. The following statements about gastrointestinal absorption are true:
x increase
A. aldosterone causes a decrease in sodium absorption
x Nach.
B. a person with cholera can be saved by administering large amounts of antivirals
C. sodium is co-transported through the brush border by specific carrier proteins
--
D. iron ions are actively absorbed from the small intestine
E. chloride exits the cell through chloride channels dehydration
-
sodium
-
fighter,
E. the tight junctions between the epithelial cells of the large intestine epithelium are
X
much looser than those of the small intestine I
-
G. the absorbing colon is the last half of the colon, where most of the absorption in the
large intestine occurs
x
Yz Absorb
=
1- 5 lost
H. only 1 to 5 mEq each of sodium and chloride ions are lost in the faeces in faeces
X
I. normally, there are no bacteria present in the absorbing colon
J. the large intestine can absorb a maximum of 5 to 8 litres of fluid and electrolytes
each day -
258. Which of the following substances are formed as a result of bacterial activity in
the large intestine?
A. vitamin K
B. vitamin B12 14B12, CO2, CH4, Thiamine
C. tocopherols
D. biotin
E. vitamin A X
F. thiamine
G. tocotrienols
H. carbon dioxide
I. pyridoxine
10-20% organic
J. methane
259. Which statements following the composition of the faeces are true?
A. the brown colour of faces is caused by skatole -
- 30% Dead
B. 30 per cent of the solid matter of faeces are proteins bacteric
C. indole, mercaptans and hydrogen sulfide are the odoriferous products in faces
D. 10 to 20 per cent of the solid matter is dead bacteria X /
J. the faeces are three-fourths solid matter and one-fourth water x Yy solid
260. Which of the following are the layers of the intestinal wall?
A. the serosa -
B. the mucosa -
G. the submucosa -
+mucosa
H. the adventitia A serosa
I. the lamina propria
J. the transitional epithelium
261. Which of the following statements about the general principles of
gastrointestinal motility are true?
A. the continuous entry
-
of calcium ions into the interior of the cell causes a tonic
contraction
they
B. the gap junctions allow high-resistance movement of ions from one muscle cell to
the next X
C. the slow waves could potentially cause muscle contractions in the stomach ~
&
-
D. excitation of the longitudinal muscle layer never excites the circular muscle layer or
do excite each one e
vice versa
E. the rhythm of the gastrointestinal contractions is determined by the frequency of the
-
slow waves
-
F. the smooth muscle of the gastrointestinal tract is excited by intermittent slow, Intrinsic
extrinsic electrical activity X
G. the calcium-sodium channels are much slower to open and close than the rapid
sodium channels of nerve fibres a
H. the motor functions of the gut are performed by the different layers of smooth
muscle X
I. the rhythm of contraction of the body of the stomach is usually about 12 per minute
J. in depolarization, the muscle fibres are the least excitable I
262. Which of the following statements about the general principles of
gastrointestinal motility are true? =contraction
A. the movement of large amounts of calcium ions to the interior of the muscle fibre
-
E. the slow waves cause the entry of sodium ions into the smooth muscle fibre
F. the smooth muscle fibres in the gastrointestinal tract are arranged in bundles of as
many as 1000 parallel fibres
G. tonic contraction often lasts a few seconds - less Negative More
-
excitable
H. norepinephrine depolarizes the membrane X
I. tonic contraction is not associated with the basic electrical rhythm of the slow waves X
-
-
J. inhibition of the sympathetic nerves that secrete mainly norepinephrine makes the
muscle fibres more excitable =USS polarized
267. The following statements about the neural control of gastrointestinal function
are true:
A. strong stimulation of the sympathetic system can stimulate motor movements of the
gut X
B. the vasoactive intestinal polypeptide inhibits the sphincter of the ileocecal valve
C. when the myenteric plexus is stimulated it decreases the intensity of the rhythmical
contractions X **
D. Auerbach and Meissner are the two plexuses composing the enteric nervous system
~
E. the vasoactive intestinal polypeptide stimulates the pyloric sphincter
F. there are 100 million neurons in the enteric system, nearly equal to the number in
-
H. 80 per cent of the nerve fibres in the vagus nerves are efferent rather than afferent -
I. the enteric nervous system is the gastrointestinal nervous system ~
J. the postganglionic neurons of the gastrointestinal parasympathetic system are
located mainly in the myenteric and submucosal plexuses ~
268. The following statements about the neural control of gastrointestinal function
are true:
A. the vasoactive intestinal polypeptide is an inhibitory transmitter secreted by the
myenteric plexus
B. the enteric
men
nervous system controls gastrointestinal movements and secretion -
C. the sigmoidal, rectal and anal regions are better supplied with parasympathetic fibres
than other intestinal areas
D. the submucosal Auerbach plexus lies in the submucosa
E. the myenteric plexus extends the entire length of the gastrointestinal tract
-
myenteric plexus
J. the submucosal plexus controls local intestinal secretion, absorption and contraction
of the submucosal muscle
269. Which of the following neurotransmitter substances are released by the enteric
neurons?
A. met-enkephalin
B. bombesin
C. gamma-aminobutyric acid
D. aspartate
E. glutamate
F. adenosine triphosphate -
G. glycine
H. histamine
I. dopamine -
J. somatostatin
pg800
Adrenaline exites Gl
Noradrenaline inhibits Gl
270. The following statements about the gastrointestinal hormone actions, stimuli
for secretion and site of secretion are true:
A. nerve, fat and acid are stimuli for the secretion of motilin
B. the site of secretion for gastrin
- -
is the G cells of the antrum, duodenum and jejunum
C. I cells of the duodenum, jejunum and ileum are the site of secretion for
cholecystokinin
D. secretin inhibits gastric emptying *
a
A. the stimuli for the secretion of motilin are proteins and carbohydrates
B. S cells of the duodenum, jejunum and ileum are the site of secretion for secretin
C. the site of secretion for cholecystokinin is the C cells of the antrum, duodenum and
jejunum G ceus*
-
C. chewing is important for the digestion of all food, but not in particular for fruits and
raw vegetables X
D. between swallows, the pharyngoesophageal sphincter relaxes X
E. the anterior teeth provide a grinding action and the posterior teeth provide a strong
XD cutting
cutting action breath
F. the pharynx subserves- respiration and -
swallowing
G. primary peristalsis in the esophagus is a continuation of the peristaltic wave that
-
begins in the pharynx
H. most of the muscles of chewing are innervated by the motor branch of the fifth
cranial nerve V
I. when the vagus nerves to the esophagus are cut, the myenteric nerve plexus of the
esophagus is inhibited X
J. the pharyngeal stage of swallowing occurs in about 30 seconds X
275. The following statements about the motor functions of the stomach are true:
A. stretching of the stomach wall inhibits the activity of the pyloric pump and stimulates
the pylorus
B. a tetanic contraction lasts less than 30 seconds X
C. the stomach can accommodate up to 0.8 to 1.5 litres
D. as each peristaltic wave approaches the pylorus, the pyloric muscle often dilates Y
E. when food stretches the stomach, a vasovagal reflex reduces the tone in the
muscular wall of the body of the stomach
F. gastrin inhibits the motor functions in the body of the stomach X
G. chyme is a semifluid mixture of food with gastric secretions ~
H. the mixing waves move toward the antrum about once every 15 to 20 seconds
I. the osmolality of the chyme initiates enterogastric stimulatory reflexes
J. the constrictor rings play an important role in mixing the stomach contents
-
276. The following statements about the motor functions of the stomach are true:
-
-
-Gceus
C. gastrin is released from the C cells of the jejunum mucosa
D. hunger contractions are most intense in young and healthy people
E. the enterogastric inhibitory reflexes are sensitive to the presence of irritants and
acids in the duodenal chyme -
F. hunger contractions are decreased by a low level of blood sugar X
-
G. the main effect of gastric inhibitory peptide is to inhibit the secretion of insulin by
the pancreas I
H. the mixing waves become more intense as they progress from the body of the
stomach into the antrum
I. the constrictor waves begin in the mid to upper portions of the stomach wall
-
-
↓
J. the pressure in the stomach remains low until the limit of 0.8 to 1.5 litres is
-
approached
277. Movements of the small intestine:
A. contractions of the villi ”milk” the villi so that lymph flows freely from the central
-
I. the segmentation contractions chop the chyme two to three times per minute
J. insulin diminishes intestinal motility X
278. Movements of the colon: eeres
A. the gastrocolic and duodenocolic reflexes result from the stretching of the stomach
-
and duodenum
B. the faecal material in the large intestine is slowly dug into and rolled over -
Aactivates
C. irritation in the colon inhibits mass movements It
D. each haustration reaches peak intensity in about 30 minutes and disappears during
the next 60 minutes
E. a mass movement is a modified type of peristalsis -
F. the longitudinal muscle of the colon is aggregated into three longitudinal strips
called the teniae coli -
G. it takes 1 hour to move the chyme from the ileocecal valve through the colon
H. the haustrations result from combined contractions of the circular and longitudinal
-
strips of muscle
-
-
B. m
chemical
ean
-
-
E. sympathetic stimulation results in constriction of the blood vessels that supply the
glands ~
F. the salivary glands are innervated by the trigeminal nerve * CNV?
G. local epithelial stimulation activates the enteric nervous system of the gut wall
H. stretching of the gut wall activates the enteric nervous system x
4
I. stimulation of the parasympathetic nerves to the alimentary tract decreases the rate
of glandular secretion I
J. tactile stimulation inhibits the enteric nervous system X
280. Secretion of saliva:
A. ptyalin is an enzyme for digesting starches ~
B. the concentrations of sodium and chloride ions in the saliva are only about 1-2 X
mEq/L
C. the electrical negativity of the salivary ducts causes chloride ions to be secreted
actively
X
D. daily secretion of saliva normally ranges between 800 and 1500 millilitres -
E. concentrations of sodium and chloride ions are several times more in saliva than in
plasma X
F. 56x
ptyalin fulfils the digestive action at a pH of 3.0 to 4.0
G. saliva contains large quantities of potassium and bicarbonate ions -
H. there is electrical negativity of about -70 millivolts in the salivary ducts
I. the concentration of bicarbonate ions in the saliva is 5 to 7 mEq/L X
was J. mucin has lubricating and surface protective purposes
- -
B. bacteria release lysozyme and thiocyanate ions to protect them against the action of
saliva
-
C. salivation is greater when a person smells or eats their favourite foods
D. saliva contains significant amounts of antibodies
- -
part
I. during sleep, little secretion of saliva occurs e Digestive
=>
J. the salivary glands are controlled mainly by - parasympathetic nervous signals from
the salivatory nuclei in the brain stem 2
282. The following statements about gastric secretion are true:
A. the oxyntic glands are located on the inside surfaces of the body and the fundus of
the stomach Parasympathetic
B. acetylcholine released by sympathetic stimulation inhibits the secretion of
- X
pepsinogen by parietal cells
X HC
C. an oxyntic gland is composed of four types of cells Form
X
D. the mucus that coats the stomach mucosa is highly acid - D
-
E. gastrin strongly stimulates the secretion of acid by parietal cells
-
F. the hydrochloric acid is formed at the villus-like projections inside the canaliculi of
the parietal cells
7
G. intrinsic factor has no role in the absorption of vitamin B12 in the ileum
H. the pyloric glands secrete only intrinsic factor x
I. the stomach mucosa has two types of tubular glands
-
oxyntic
- -plyoric
- -
-
J. the mucous neck cells secrete mainly mucus -
283. The following statements about gastric secretion are true:
*
A. histamine strongly inhibits the secretion of acid by parietal cells
B. for hydrochloric acid secretion is required a hydrogen-potassium pump
C. the pyloric glands are located in the proximal 80 per cent of the stomach
D. the oxyntic glands secrete only mucus
-
E. acetylcholine released by parasympathetic stimulation excites secretion of
pepsinogen by peptic cells
F. gastric venous blood has a lower pH than arterial blood when the stomach is ~
secreting acid
G. when pepsinogen is first secreted, it has no digestive activity
-
oxyntic
-
isotonic
-
of hydrochloric acid #U
D. the pyloric glands secrete gastrin nearly
E. the oxyntic glands are located in the distal 20 per cent of the stomach
X
H. to concentrate the hydrogen ions it is required more than 1500 calories of energy
per litre of gastric juice Histamin
I. the chief cells secrete hydrochloric acid and intrinsic factor
=>
=STIMULATE
J. histamine strongly stimulates the secretion of acid by parietal cells
- secretion.
285. The following statements about gastric secretion are true:
A. stimulation of pepsinogen secretion occurs in response to epinephrine released from
the vagus nerve He
S
B. when stimulated, the parietal cells secrete an acid solution, which is nearly hypertonic
in comparison with the body fluids Above 5?
T
C. pepsin has no proteolytic activity and becomes completely inactivated at a pH of 1.8
to 3.5 PH above 5
D. pepsin is not influenced by the amount of acid in the stomach
E. the peptic cells secrete large quantities of pepsinogen =@
mucous cells
--
Activates
C. the reverse enterogastric reflex can be initiated by the constriction of the small bowel
and the absence of acid in the upper intestine I
D. the parietal cells operate in close association with enterochromaffin-like cells (ECL
cells)
⑰
E. the pyloric glands are structurally similar to the oxyntic glands
-
292. The following statements about secretions of the small intestine are true:
A. the crypts of Lieberkühn secrete almost pure extracellular fluid
- -
B. the mucus secreted by Brunner’s glands protects the duodenal wall from digestion
by the highly acidic gastric juice emptying from the stomach -
E. maltase and isomaltase are peptidases with a role in splitting small peptides into
amino acids *
F. the life cycle of an intestinal epithelial cell is about 5 hours X
- G. lipase is a digestive enzyme with a role in splitting neutral fats into glycerol and fatty
acids ~
H. the intestinal secretions are never reabsorbed by the villi X
~
- I. Brunner’s glands are located in the wall of the first few centimetres of the duodenum
J. the intestinal secretions have a pH in the range of 4.0-5.0 X
293. The following statements about the digestion of food by hydrolysis are true:
A. starches are disaccharides found in milk X
B. one of the most important features of pepsin digestion is its ability to digest collagen
~
-
-
A
C. pancreatic secretion, like saliva, contains a large quantity of a-amylase
I
D.
E.
-
triglycerides are composed of three glycerol nucleus and one fatty acid side chain
sucrose is a disaccharide known as cane sugar
F. enteric lipase is present in enormous quantities in the pancreatic juice ~
X
G. elastase is converted into proelastase, which digests elastin fibres
X 50%
H. glucose represents about 10 per cent of the final products of carbohydrate digestion ↓
-
I. only three major sources of carbohydrates exist in the normal human diet
J. almost all the carbohydrates in the diet are either large polysaccharides or
disaccharides e
294. The following statements about the digestion of food by hydrolysis are true:
A. phospholipase A2 hydrolysis the cholesterol ester
B. dietary proteins are chemically long chains of amino acids bound together by
peptide linkages ~
C. through hydrolysis, the fat-digesting enzymes return three molecules of water to the
triglyceride molecule and split the fatty acid molecules away from the glycerol ~
D. the a-amylase of saliva is several times more powerful than the pancreatic a-amylase X
E. lactase, sucrase, maltase and a-dextrinase split the disaccharides into their
constituent monosaccharides inactive after 5
x
F. pepsin is most active at a pH above about 5.0
G. starches are present in almost all non-animal foods
- -
E. the most important enzyme for the digestion of triglycerides is pancreatic lipase -
F. 5 per cent of all the starches will be hydrolyzed by the time the food is swallowed
-
G. most of the triglycerides of the diet are split by pancreatic lipase into free fatty acids
-
and 2-monoglycerides
H. monosaccharides are the final products of carbohydrate digestion -
I. pectins are a type of carbohydrates -
J. the amylase is most active once the pH of the medium is below 5.0 X
296. The following statements about gastrointestinal absorption are true:
A. the effect of aldosterone on sodium absorption is especially important in the colon
because it allows the loss of sodium chloride in faeces X
B. sodium is actively transported through the intestinal membrane ~
C. chloride ion absorption is rapid in the upper part of the small intestine
D. sodium concentration in the chyme is normally about 50 mEq/L X
E. the total quantity of fluid that must be absorbed each day by the intestines is equal
-
to the ingested fluid plus that secreted in the various gastrointestinal secretion
-
↑
F. 10 per cent of the intestinal sodium is lost in the faeces each day X
G. alcohol is a highly lipid-soluble substance that can be absorbed in the stomach in
small quantities -
H. absorption of sodium ions through the epithelium creates electronegativity in the
paracellular spaces between the epithelial cellsX
I. the stomach is a poor absorptive area of the gastrointestinal tract -
J. in the paracellular pathway, osmosis occurs through the cells themselves -
297. The following statements about gastrointestinal absorption are true: ↑Nat
A. within 1 to 3 hours aldosterone decreases the activation of the enzyme and transport b3
mechanisms for sodium absorption by the intestinal epithelium Kenzyme stopping
B. sodium is co-transported through the brush border membrane by the sodium- Absorbtio
hydrogen exchanger
- -
ofNa
C. calcium ions are actively absorbed into the blood
-
-
G. extending from the epithelial cell body into each microvillus of the brush border are
multiple actin filamentsthat contract rhythmically to cause continual movement of
-
the microvilli
H. amino acids are never transported by facilitated diffusion, only by active transport X
I. sodium plays a role in helping absorb sugars and amino acids -
J. when sodium ions are absorbed, moderate amounts of hydrogen ions are secreted
into the lumen of the gut in exchange for some of the sodium -
299. The following statements about absorption in the large intestine are true:
A. the mucosa of the large intestine absorbs chloride ions in an exchange transport
process myz: Absorption
-
B. the storage colon is represented by the distal half of the colon
X
C. more than 10 mEq of sodium ions are lost in the faeces
D. the absorbing colon is represented by the proximal one-half of the colon e
E. aldosterone enhances sodium transport capability -
F. the bacteria-formed vitamin A is especially important in maintaining adequate blood
coagulation 4 X
G. more than 500 millilitres of fluid are excreted in the faeces
H. about 1500 millilitres of chyme normally pass through the ileocecal valve into the
- ~
large intestine each day
I. the colon bacilli are not capable of digesting cellulosef
J. the large intestine can absorb a maximum of 1 litre of fluid and electrolytes each day ->
300. Which statements following the composition of the faeces are true?
A. the odour of faeces is independent of the person’s colonic bacterial flora and the
type of->food eaten
B. 2 to 3 per cent of the solid matter is represented by protein -
C. the faeces normally are composed only of solid matter -
D. skatole is an odoriferous product ~
~
E. 30 per cent of the solid matter is represented by dead bacteria
⑭
F. undigested roughage is represented by the food and dried constituents of digestive
juices, such as bile pigment and sloughed epithelial cells -
Dead bacteria
30=
10-20%-Fat
2 3=
-protein.