Exportlist

TY - JOUR
AN - rayyan-563561206
IS - 12
KW - chlorhexidine gluconate
placebo
drug therapy
gingivitis
pharmacology
therapy
tooth brushing
topical drug administration
corsodyl
LA - English
PY - 1976
SN - 0012-6543
SP - 47-48
ST - Chlorhexidine gel (Corsodyl) for gingivitis?
T2 - DRUG THER. BULL.
TI - Chlorhexidine gel (Corsodyl) for gingivitis?
UR - https://www.embase.com/search/results?
subaction=viewrecord&id=L7081829&from=export U2 - L7081829
VL - 14
ID - 14580
ER -
TY - JOUR
AB - Periodontal disease is a major cause of tooth loss. The underlying pathology
is inflammation caused by bacterial plaque affecting the supporting structures of
the teeth. Conventional treatment involves mechanical debridement of calcified
plaque (calculus) by the dentist combined with meticulous oral hygiene by the
patient. A more recent approach is to apply antimicrobial drugs locally to the
diseased gingival tissue after debridement. Two antibiotic preparations,
minocycline 2% gel (Dentomycin-Lederle) and metronidazole 25% gel (Elyzol-Dumex),
are now licensed for the treatment of patients with periodontal disease. Are these
treatments an advance on conventional therapy?
AN - rayyan-563561345
DO - 10.1136/dtb.1994.32643
IS - 6
J2 - Drug Ther Bull
KW - Gels
Humans
Metronidazole/*therapeutic use
Minocycline/*therapeutic use
Oral Hygiene
Periodontal Diseases/*drug therapy/prevention & control
LA - eng
PY - 1994
SN - 0012-6543 (Print)
SP - 43-4
ST - Antibiotic gels for periodontal disease
T2 - Drug and therapeutics bulletin
TI - Antibiotic gels for periodontal disease
UR - https://pubmed.ncbi.nlm.nih.gov/7635031/
VL - 32
Y2 - 6 y3 - 16
ID - 14719
ER -
TY - JOUR
AN - rayyan-563560891
IS - 1
KW - antiinfective agent
minocycline
article
dental health education
endoscope
gel
human
light
periodontitis
LA - English
PY - 2003
SN - 8750-2186
SP - 32
ST - Nonsurgical periodontal therapy reviewed
T2 - Dent Today
TI - Nonsurgical periodontal therapy reviewed
VL - 22
ID - 14265
ER -
TY - JOUR
AN - rayyan-563560699
IS - 5
KW - 2,4 dichlorobenzyl alcohol
antiinfective agent
carboxymethylcellulose
unclassified drug
water
article
drug formulation
drug indication
drug labeling
drug packaging
drug stability
gel
gingivitis
quality control
tooth infection
LA - English
PY - 2008
SN - 1092-4221
SP - 449
ST - Dichlorobenzyl alcohol tooth gel
T2 - Int. J. Pharm. Compd.
TI - Dichlorobenzyl alcohol tooth gel
VL - 12
ID - 14073
ER -
TY - JOUR
AN - rayyan-563560634
IS - 4
KW - flurbiprofen
hydroxyethylcellulose
methyl paraben
polycarbophil
polysorbate 80
povidone
propyl paraben
sodium chloride
drug labeling
drug packaging
drug stability
gel
gingivitis
quality control
short survey
LA - English
PY - 2010
SN - 1092-4221
SP - 341
ST - Flurbiprofen 5% bioadhesive gel for gingivitis
TI - Flurbiprofen 5% bioadhesive gel for gingivitis
VL - 14
ID - 14008
ER -
TY - JOUR
AN - rayyan-563561952
N1 - Export Date: 08 September 2023; Cited By: 0
PY - 2013
ST - 2012 International Conference on Biomaterial and Bioengineering, ICBB 2012
T2 - Advanced Materials Research
TI - 2012 International Conference on Biomaterial and Bioengineering, ICBB 2012
UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-
84873875825&partnerID=40&md5=9f966cff2e3f9ad2beb87cfcd981a039
VL - 647
ID - 15326
ER -
TY - JOUR
AB - The proceedings contain 136 papers. The topics discussed include: solid self
nano emulsifying drug delivery system (snedds): a potential dosage form to enhance
solubility of ramipril; enhance solubility of albendazole drug by mesoporous
material; design and characterization of multiparticulate gastroretentive floating
drug delivery system; development and characterization of sprayable in situ gel of
allantoin; renewed role and responsibilities of pharmacists in pharmacy practice;
development, characterization and optimization of fast dissolving tablets of
domperidone; development of stable lyophilized nanosuspension of felodipine by
using latex of jatropa curcas as stabilizer; gel loaded dental implant: a demiurgic
drug delivery system for treatment of gingivitis; formulation development and
optimization of dorzolamide ph triggered ophthalmic in situ gelling system; and
preparation and development of drug loaded mucoadhesive microspheres against h.
pylori infection.
AN - rayyan-563560349
IS - 3
KW - ramipril
allantoin
albendazole
felodipine
domperidone
latex
stabilizing agent
dorzolamide
microsphere
pharmaceutics
drug delivery system
solubility
pharmacist
tablet
responsibility
tooth implant
human
pharmacy (shop)
pH
Jatropha
gingivitis
drug dosage form
pylorus
infection
solid
LA - English
PY - 2016
SN - 0975-1491
ST - International Conference on Innovations in Pharmaceutical Sciences, ICIPS
2016
T2 - Int. J. Pharmcy Pharm. Sci.
TI - International Conference on Innovations in Pharmaceutical Sciences, ICIPS
2016
VL - 8
ID - 13723
ER -
TY - JOUR
AN - rayyan-563561752
DO - 10.37988/1811-153X_2019_4_46
IS - 4
PY - 2019
SP - 46-49
ST - Comparative analysis of therapeutic effects of terpenoid-containing vegetable
agent and chlorhexidine in experimental parodontitis
T2 - Clinical Dentistry (Russia)
TI - Comparative analysis of therapeutic effects of terpenoid-containing vegetable
agent and chlorhexidine in experimental parodontitis
85150773752&doi=10.37988%2f1811-
153X_2019_4_46&partnerID=40&md5=a26ae128a5d420759cbeaef00a39f62f
ID - 15126
ER -
TY - JOUR
AN - rayyan-563560073
DO - 10.1016/S1773-2247(20)31540-9
KW - contact lens
microneedle
osmotic pump
wound dressing
cannabis
cardiovascular agent
curcumin
DNA
docetaxel
dodecyl sulfate sodium
dye
essential oil
firtecan
graphene oxide
hydrogel
ketamine
ketotifen
linoleic acid
liposome
magnetoliposome
nanocarrier
nanodiamond
nanofiber
nanomaterial
nanosheet
peptide
photosensitizing agent
polymer
porphyrin
povidone
ropocamptide
silymarin
solid lipid nanoparticle
unclassified drug
zinc oxide nanoparticle
adipose derived stem cell
allergic conjunctivitis
Aloe vera
antibiotic resistance
antidiabetic activity
antiinflammatory activity
antineoplastic activity
antioxidant activity
apoptosis
apple
artificial neural network
bilayer membrane
biocompatibility
biofilm
biological activity
biosynthesis
black cumin
bone conduction
bone regeneration
breast cancer
breast carcinoma cell line
cancer cell
cancer cell line
cancer therapy
cartilage
cell culture
cell death
cell vacuole
cellulite
chemical modification
chemical structure
Chinese medicine
chloasma
chondrocyte
chondrogenesis
chronic disease
chronic wound
clinical trial (topic)
computer model
controlled drug release
coriander
cornea permeability
coronavirus disease 2019
cross linking
cytotoxicity
degradation kinetics
diagnostic imaging
dispersion
dissolution
drug bioavailability
drug degradation
drug design
drug efficacy
drug formulation
drug penetration
drug release
drug safety
drug solubility
drug synthesis
editorial
electrospinning
electrospray
emu
Eugenia
Eugenia brejoensis
ex vivo study
exosome
experimental design
fluorination
freezing
gastrointestinal tract
gene overexpression
genetic engineering
genotoxicity
glioblastoma
heart infarction
heat sensitivity
hepatocellular carcinoma cell line
high intensity ultrasound
human
hydrolysis
in vitro study
in vivo study
infection
infectious agent
inflammation
jet injection
keratomycosis
knee osteoarthritis
Leporidae
lung cancer
medical technology
melanoma
membrane potential
Mentha
Mentha mozaffarianii
microemulsion
microencapsulation
migraine
Mycobacterium tuberculosis
mycosis
nanobiotechnology
nanoemulsion
nanoencapsulation
nanomedicine
nanotechnology
nerve fiber regeneration
neuropathic pain
nonhuman
nonviral gene delivery system
nuclear magnetic resonance imaging
oral absorption
osteosarcoma cell
particle size
periodontitis
pH
pharmaceutical care
pharmacokinetic parameters
photodynamic therapy
physical chemistry
pig
polymerization
powder
premature labor
prostate cancer
quality by design
radiation protection
regenerative medicine
reverse micelle
rheumatoid arthritis
rice bran
scale up
Sida rhombifolia
skin
skin absorption
skin cancer
skin infection
spinal cord injury
spray drying
stem cell
structure activity relation
surface property
sustained drug release
synergistic effect
tablet disintegration
taste
tea
tensile strength
theranostic nanomedicine
thrush
tight junction
tissue preservation
tissue regeneration
tuberculosis
tumor growth
tumor microenvironment
ulcerative colitis
ultraviolet radiation
vagina candidiasis
wound care
wound healing
WST assay
zebra fish
LL 37
sn 38
LA - English
PY - 2020
SN - 1773-2247
ST - Graphical Abstract TOC
T2 - J. Drug Deliv. Sci. Technol.
TI - Graphical Abstract TOC
VL - 60
ID - 13447
ER -
TY - JOUR
AN - rayyan-563559989
DO - 10.1016/S1773-2247(21)00300-2
KW - contact lens
corneal collagen cross-linking device
drug delivery device
microneedle
tissue scaffold
transdermal patch
transmucosal drug delivery system
wound dressing
alaptide
albumin
anacardic acid
Andrographis paniculata extract
antidiabetic agent
antiinfective agent
antineoplastic agent
apremilast
aptamer
aripiprazole
artemether
ascorbic acid
beta cyclodextrin
biopolymer
bromelain
brucine
budesonide
buffer
bulking agent
buprenorphine
captopril
carbon dioxide
carbon nanotube
carbonic acid derivative
carboxylic acid
carrageenan
caspase 3
ceftriaxone
cellulose
chitosan
chitosan nanoparticle
chondroitin sulfate
clotrimazole
collagen
Cordia myxa extract
cosmetic
curcumin
cyanocobalamin
cyclohexane derivative
cyclosporine
cytotoxic agent
dendrimer
dicarboxylic acid
dihydroartemisinin
docosahexaenoic acid
domperidone
donepezil
doxorubicin
drug carrier
enzyme
epirubicin
essential oil
ethyl cellulose
ferulic acid
fish oil
fluconazole
fluorouracil
folate receptor
folic acid
forkhead box protein M1
gallic acid
gel
gelatin
glibenclamide
glutamine
phytosome
gold nanoparticle
graphene
graphene oxide
herbaceous agent
hydrogel
hydroxychloroquine
ibrutinib
ibuprofen
icosapentaenoic acid
ionic liquid
irbesartan
irinotecan
itraconazole
ivabradine
ketoconazole
linseed oil
lipopolysaccharide
liposome
luteolin
lycopene
magnesium
magnetic nanoparticle
meclozine
meloxicam
memantine
mesoporous silica nanoparticle
metal organic framework
metformin
methacrylic acid
methotrexate
microRNA 10b
microsphere
molecular scaffold
monoclonal antibody
nanocapsule
nanocarrier
nanocomposite
nanofiber
nanomaterial
nanoparticle
nanoribbon
naproxen
natural product
niosome
oil
oleic acid
oxcarbazepine
paclitaxel
phosphate
phosphatidylcholine
piperine
plant extract
polycaprolactone
polyelectrolyte
polymethacrylic acid
polysaccharide
polysorbate 80
polyvinyl alcohol
polyvinyl derivative
pregabalin
prodrug
propranolol
quercetin
raloxifene
reducing agent
resveratrol
ritonavir
Rosmarinus officinalis extract
rosuvastatin
rotigotine
self assembled nanoparticle
silver nanoparticle
silymarin
small interfering RNA
sodium chloride
sorafenib
starch
tacrolimus
tamoxifen
taxifolin
tea tree oil
tetrahydrocurcumin
unclassified drug
vegetable oil
vinorelbine tartrate
Withania coagulans extract
Zingiber montanum extract
acidity
aging
allopathy
Alzheimer disease
Andrographis paniculata
antibacterial activity
anticonvulsant therapy
antimalarial activity
antioxidant assay
antiparasitic activity
apoptosis
atherosclerosis
bacteriophage
bark
biocompatibility
biomimetics
biosynthesis
bone development
bone regeneration
brain
breast cancer
cancer cell
cancer chemotherapy
cancer therapy
candidiasis
Cedrus
cell differentiation
cell engineering
cell protection
Cinnamomum zeylanicum
colon
colorectal cancer
computer model
crystal structure
degenerative disease
diabetic wound
diatom
disease association
drug absorption
drug capsule
drug design
drug dosage form comparison
drug efficacy
drug formulation
drug penetration
drug release
drug repositioning
drug retention
drug solubility
drug structure
drug synthesis
drug targeting
drug uptake
editorial
effervescent tablet
electrospinning
equipment design
ex vivo study
exosome
experimental design
extracellular matrix
feasibility study
fruit
gingivitis
Gram negative bacterium
Gram positive bacterium
grinding
histopathology
honey
hot melt extrusion
human
hyperthermia
hypobaric chamber
in vitro study
in vivo study
incubation time
inhalational drug administration
injection site reaction
intestine tumor
intraocular drug administration
jet injection
keratoconus
larvicidal activity
Leishmania major
Leishmania tropica
Lepidium sativum
leukemia
liposomal delivery
liver cancer
liver protection
lyophilisate
macrophage
mass fragmentography
mechanotransduction
medicine
melanoma cell
micelle
microfluidics
mouth cancer
mouth ulcer
mucoadhesion
nanoemulsion
nanofabrication
nanomedicine
nanotechnology
nausea
nephritis
neurologic disease
nonhuman
onion
oral cancer cell line
oxidative stress
pancreas cancer
particle size
pH
physical chemistry
polymerization
prediction
process optimization
psoriasis
quality by design
quantum chemistry
radiolabeling
RAW 264.7 cell line
signal transduction
single drug dose
skin infection
skin injury
skin penetration
squamous cell carcinoma
Staphylococcus infection
stem cell
stingless bee
streptozotocin-induced diabetes mellitus
supramolecular chemistry
surface property
sustained release formulation
synergistic effect
systematic review (topic)
tablet
thrush
tissue engineering
topical treatment
transdermal drug administration
vomiting
water vapor
wettability
Withania coagulans
wound healing
Zingiber montanum
LA - English
PY - 2021
SN - 1773-2247
VL - 63
ID - 13363
ER -
TY - JOUR
AN - rayyan-563559807
DO - 10.1016/S1773-2247(22)00688-8
KW - microneedle
2 (2 cholesteroxyethoxyl)ethyl 3' glutathionylpropionate
albumin
alginic acid
antisense oligonucleotide
aptamer
arsenic
aurantiin
azelaic acid
borage oil
brimonidine
carbon nanotube
carrageenan
celastrol
cellulose nanofiber
chitosan
cilazapril
colecalciferol
cosmeceutical
curcumin
cyclodextrin
deep eutectic solvent
dendrimer
dexamethasone acetate
diethylnitrosamine
docetaxel
donepezil
doxorubicin
drug carrier
exemestane
fatty acid
ferulic acid
fibroblast growth factor 2
fluconazole
fluorouracil
glutamic acid
gold nanorod
harmine
hyaluronic acid
hydrogel
hydroxide
hydroxyl radical
hydroxypropylmethylcellulose
icariside II
idebenone
indium 111
insulin
iron oxide nanoparticle
keratin
lapatinib
legumain
lignin
lipoplex
liposome
lomustine
mannitol
mepacrine
microsphere
monoclonal antibody J591
nanocarrier
nanocellulose
nanocomposite
nanofiber
nanogel
nanoparticle
neem oil
nimbolide
niosome
nitric oxide
paclitaxel
pectin
pentoxifylline
peptide
phosphatidylserine
piperine
platinum
poloxamer
polyvinyl alcohol
quercetin
raloxifene
ranolazine
reactive oxygen metabolite
rebamipide
rhamnolipid
rosuvastatin
Schiff base
sesame seed oil
silk fibroin
silymarin
sunscreen
tetracycline
titanium dioxide nanoparticle
topotecan
unclassified drug
vanadium
vancomycin
zinc oxide
acne vulgaris
Aedes aegypti
angina pectoris
antihypertensive activity
antiproliferative activity
apoptosis
arthritis
artificial intelligence
Astrocaryum murumuru
bacterial infection
brain
breast cancer
burn
cell cycle arrest
central composite design
central nervous system
circulating tumor cell
cross linking
cutaneous leishmaniasis
degradation
dermatitis
diabetes mellitus
DNA fragmentation
drug efficacy
drug granulation
drug release
drug solubility
dry eye
editorial
electrospinning
emulsion
exosome
genetic transfection
genotoxicity
human
in vivo study
infection
intravaginal drug administration
keratomycosis
leukemia
liver cell carcinoma
LNCaP cell line
lung cancer
malignant neoplasm
medical literature
melanoma
micelle
microfluidics
mitochondrion
nanoemulsion
nanotechnology
non small cell lung cancer
nonhuman
nonviral gene therapy
nose
osteoporosis
pediatric patient
periodontitis
pH
photothermal therapy
phytotherapy
promyelocytic leukemia
psoriasis
response surface method
Santolina chamaecyparissus
single drug dose
static electricity
subarachnoid space
temperature
three dimensional printing
tissue regeneration
triple negative breast cancer
tuberculosis
tumor cell
vaccination
wound healing
xerostomia
zebra fish
LA - English
PY - 2022
SN - 1773-2247
VL - 75
ID - 13181
ER -
TY - JOUR
AN - rayyan-563559735
DO - 10.1016/S1773-2247(23)00270-8
KW - fluidized bed
wurster fluidized bed
2 hydroxypropyl beta cyclodextrin
3 carene
abiraterone acetate
aerogel
agarose
agents acting on the eye
alginate dialdehyde
alginic acid
almond oil
alogliptin
alpha tocopherol
ampicillin
angiogenic factor
antifibrotic agent
antiinflammatory agent
artemether
atorvastatin
bergenin
betaxolol
biomaterial
bitter almond oil
bovine serum albumin
cabazitaxel
cadmium oxide
carbamazepine
carboxymethyl chitosan
Carissa carandas linn leaf extract
chitosan
chitosan sodium alginate polyglactin microsphere
choline
Chromolaena odorata extract
citicoline
Citrus limetta peel extract
curcumin
cyclodextrin
dapagliflozin
deep eutectic solvent
dexamethasone
double responsive shrinkable nanoparticle
doxycycline
drug carrier
erythromycin
essential oil
eudragit
evodiamine
excipient
eye drops
fluorouracil
forskolin
gallic acid
gamma cyclodextrin
garlic extract
gelatin
glatiramer
gold nanoparticle
gold nanorod
graphene oxide
guar gum
halloysite
highly permeable ocular bilosome
human insulin
hydrogel
hydroxyapatite
ibuprofen
immunoglobulin enhancer binding protein
in situ forming gel
inorganic compound
lapatinib
laponite
limonene
lipid nanoparticle
liposome
macrogol
meloxicam
microsphere
molybdenum disulfide
montmorillonite
moxifloxacin
nanobubble
nanocarrier
nanocomposite
nanocrystal
nanofiber
nanohydrogel
nanomaterial
naringenin
neomycin
oligonucleotide
oligosaccharide
orphan drug
oxypeucedanin
palbociclib
pdlim5 protein
pectin
peptides and proteins
phytochemical
pirfenidone
plant extract
plasmid DNA
poloxamer
polyamide 6
polyethyleneimine
polyethylenimine polyplexes
polyglactin
polyglactin polyethyleneimine nanobubble
polymer matrix nanocomposite
polymer nanoparticle
polysaccharide
polyvinyl alcohol
povidone
programmed death 1 ligand 1
propolis
protein
protein tyrosine kinase inhibitor
pullulan
quantum dot
quercetin
recombinant growth factor
recombinant human epidermal growth factor
rutoside
short hairpin RNA
single chain fragment variable antibody
sirolimus
sodium iodate
somatostatin receptor 2
sorafenib
stabilizing agent
STAT3 protein
sugar
tetrahydropalmatine
thiol
two dimensional nanomaterial
unclassified drug
vancomycin
water
xanthohumol
xylitol
zirconia nanoparticle
Alzheimer disease
animal model
antiangiogenic activity
antibiofilm activity
apoptosis
artificial intelligence
bacterial arthritis
bioavailability
biocompatibility
bone tissue
breast cancer
breast cancer cell line
breathing
breathing induced stretch
burn
Calotropis gigantea
cancer cell
cancer diagnosis
cancer recurrence
cancer resistance
cancer therapy
cartilage
cell engineering
cell invasion
cell migration
cell proliferation
Chromolaena odorata
Citrus
Citrus limetta
colorectal liver metastasis
combination drug therapy
computer model
conjugation
cream
crystal
cystic fibrosis
cytokine storm
cytotoxicity
diabetes mellitus
diagnostic imaging
disease control
down regulation
drug design
drug dosage form
drug formulation
drug release
drug repositioning
drug screening
drug solubility
drug synthesis
drug-resistant cell line
editorial
electrospinning
encapsulation
endocytosis
enteric coated tablet
erratum
ex vivo study
exosome
glaucoma
glioma cell
high performance liquid chromatography
hot melt extrusion
human
human epidermal growth factor receptor 2 positive breast cancer
immunoregulation
in vitro study
in vivo study
indomethacin-induced gastric ulcer
Leishmania
liposomal delivery
liquid crystal
liquisolid formulation
lung cancer
Lycium barbarum
lyophilisate
metastatic breast cancer
micellar liquid chromatography
micelle
micronization
molecular docking
molecular weight
nanoemulsion
nanoformulation
nanomedicine
nanotechnology
near infrared spectroscopy
non small cell lung cancer
nonhuman
nonviral gene delivery system
osteoarthritis
osteosarcoma
PC-9/GR cell line
periodontal disease
pharmaceutical care
photothermal chemotherapy
physical chemistry
proof of concept
protein expression
Pseudomonas aeruginosa
quality by design
radiosensitization
rat model
RAW 264.7 cell line
respiratory tract allergy
retina degeneration
retraction notice
self nanoemulsifying drug delivery system
skin
skin cancer
skin injury
spectroscopy
spray drying
subacute oral toxicity
sublingual film
supercritical fluid
supplementation
suspension
synergistic effect
synthesis
tablet compression
tablet friability
tea
therapy
tissue engineering
tissue regeneration
tissue repair
topical treatment
toxicity
toxicity assay
triple negative breast cancer
unlicensed drug use
wound care
wound healing
wound infection
LA - English
PY - 2023
SN - 1773-2247
VL - 82
ID - 13109
ER -
TY - JOUR
AB - The article presents the results of a pharmacodynamic study of a new gel
containing an extract of Aloe vera and an extract of oak bark under the condition
of destructive inflammatory periodontal diseases. Pharmacodynamics of the new gel
was studied by the following methods: antimicrobial effect - by diffusion method in
agar gel (compared product - Metrogyl denta® gel); reparative effect - on the model
of linear cut wounds (compared product - Calendula ointment); anti-inflammatory
activity - on the model of acute carrageenan-induced inflammation (compared product
- Diclofenac natrium gel 5%). It has been established that the antimicrobial
activity of the new gel against Staphylococcus aureus ATCC 25923, Escherichia coli
ATCC 25922, Bacillus subtilis ATCC 6633, Pseudomonas aeruginosa ATCC 27853, Candida
albicans NCTC 885-653, Escherichia faecalis ATCC 29212, and Staphylococcus mutans
ATCC 35668 is slightly lower in comparison with Metrogyl denta® gel exhibiting
a powerful antimicrobial activity. According to the reparative effect on the model
of linear cut wounds, the new gel exceeded the effectiveness (by 24%, p < 0.001) of
the compared drug based on the medicinal plant material - Calendula ointment.
A significant anti-inflammatory activity of the new gel has been revealed under the
conditions of acute carrageenan inflammation. It exceeded the Diclofenac natrium
gel in the first hours of the experiment, indicating an anti-lipoxygenase activity
of the new gel. The established antimicrobial, reparative and anti-inflammatory
activity of a new gel containing aloe vera and oak bark extracts confirmed its
potential use in the treatment of destructive inflammatory periodontal diseases.
AN - rayyan-563560974
AU - A, T. N.
AU - S, Z. D.
IS - 3
J2 - Ceska Slov Farm
KW - Aloe/*chemistry
Anti-Infective Agents/pharmacology
Gels
Humans
Microbial Sensitivity Tests
*Periodontal Diseases/drug therapy
Plant Bark/chemistry
Plant Extracts/*pharmacology
Quercus/*chemistry
LA - eng
PY - 2020
SN - 1210-7816 (Print)
SP - 143-148
ST - A pharmacodynamic study of a new gel containing an extract of Aloe vera and
an extract of oak bark for potential treatment of periodontal diseases
T2 - Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a
Slovenske farmaceuticke spolecnosti
TI - A pharmacodynamic study of a new gel containing an extract of Aloe vera and
VL - 69
ID - 14348
ER -
TY - JOUR
AB - The current work aimed to study the propagation of Staphylococcus aureus and
Candida sp. and. in oral cavity of the human, and their effective on innetimmune
response and to describe the biochemical &kinetic properties of PLB from the
Staphylococcus aureus. and asporogenous yeast C. tropicalis. The study included 25
patients, ages (12-65) years, with periodontal diseases and at least two sites with
probing depth ≥ 3 mm. Participants' data were assessed individually. A sample is
taken from the oral cavity (mucous membrane, tongue and cheek) with a sterile swab.
Among all the patients studied, (16) 64% showed Staphylococcus in the oral cavity
while Streptococcus sp (3) 12% showed candidiasis in the oral cavity and (5) 20 %
of other bacteria(1) 4% in the oral cavity. The effect of microbial inflammation on
the multidirectional secretion of interleukin (IL)-10, IL-6 has been studied in
patients with oral cavity infections. Samples and wash swabs were taken from 25
healthy patients and 25 patients. The supernatant fractions of IL-6 and IL-10 were
examined by commercial ELISAs. Analysis of interleukin levels in the two groups
with the Mann-Whitney test.IL-6 levels various significantly between the patients,
the control group, and the control groups. Median levels of IL-10 in both groups
were uniformly low but the mean levels were not statistically different. The
observed change in bacterial flora that is characteristic of stomatitis does not
enhance or suppress oral levels of IL-6 and IL-10. Staphylococcus aureus, and
Candida tropicalis have been isolated oral cavity and under the periodontal sinuses
infection. It was filtered 2.5 fold at40 ºC from a culture broth and has an
estimated molecular mass of 50kDa.The enzyme was two pH targets, one acid (pH 4.0)
and other alkaline (pH 7.5). At acidic pH the enzyme showed a higher affinity for
all tested phospholipids without metal ions while its affinity affected by the
presence of metal ions at alkaline conditions and the enzyme activity inhibited by
Fe3+ and Hg2+.
AN - rayyan-563559825
AU - Abbas, M. K.
AU - Abdul, F. R.
AU - Rasool, K. H.
DO - 10.52711/0974-360X.2022.00522
IS - 7
KW - acyltransferase
interleukin 10
interleukin 12
interleukin 6
lysophospholipase
article
bacterial flora
bacterium isolation
blood sampling
Candida tropicalis
candidiasis
clinical article
controlled study
enzyme activity
enzyme linked immunosorbent assay
enzyme specificity
human
molecular weight
mouth cavity
mouth infection
nonhuman
periodontal disease
periodontal pocket depth
pH
polyacrylamide gel electrophoresis
protein purification
Staphylococcus aureus
LA - English
PY - 2022
SN - ["0974-360X", "0974-3618"]
SP - 3119-3124
ST - Immunological and Enzymatic study of Staphylococcus aureus Bacteria and fungi
isolated from oral cavity
T2 - Res. J. Pharm. Technol.
TI - Immunological and Enzymatic study of Staphylococcus aureus Bacteria and fungi
isolated from oral cavity
VL - 15
ID - 13199
ER -
TY - JOUR
AB - INTRODUCTION: The aims of this study were i) to define the chemical
constituents of Cuminum cyminum (cumin) essential oil, ii) to compare the
antimicrobial activity of this oil to that of chlorhexidine (CHX) and co-
trimoxazole on planktonic and biofilm forms of bacteria isolated from the teeth
with persistent endodontic infection and iii ) to compare the cytotoxicity of these
medicaments on L929 fibroblasts. METHODS AND MATERIALS: Three groups of
microorganisms [aerobic bacterial mixture, anaerobic bacterial mixture and
Enterococcus faecalis (E .faecalis)] were isolated from the teeth with persistent
apical periodontitis. Zone of inhibition (ZOI), minimum inhibitory concentration
(MIC), minimum bactericidal concentration (MBC), minimum biofilm inhibitory
concentration (MBIC) and time-kill tests were performed to assess the antimicrobial
efficacy of the medicaments. Further, a cytocompatibility analysis of the
medicaments was performed on L929 fibroblasts. The results obtained from disc
diffusion test and mean cell viability values of the experimental medicaments were
analyzed using two-way and one-way analysis of variance (ANOVA). RESULTS: Seventeen
constituents were recognized in cumin oil (predominantly cumin aldehyde and γ-
terpinene). Co-trimoxazole showed the greatest ZOI followed by cumin and CHX. The
smallest MIC and MBC belonged to co-trimoxazole followed by cumin and CHX for all
groups of bacteria except for E. faecalis for which the MBC of cumin was smaller
than co-trimoxazole. The results of time-kill assay revealed that all medicaments
totally inhibited the bacterial growth in all groups after 24 h. CHX was the most
cytotoxic solution while there were no significant differences between the
cytocompatibility of different concentrations of cumin essential oil and co-
trimoxazole. CONCLUSION: Cumin exhibited a strong antimicrobial efficiency against
the microbial flora of the teeth with failed endodontic treatments and it was
biocompatible for L929 mouse fibroblasts.
AN - rayyan-563560831
AU - Abbaszadegan, A.
AU - Gholami, A.
AU - Ghahramani, Y.
AU - Ghareghan, R.
AU - Ghareghan, M.
AU - Kazemi, A.
AU - Iraji, A.
AU - Ghasemi, Y.
DO - 10.7508/iej.2016.01.009
IS - 1
J2 - Iran Endod J
LA - eng
N1 - Department of Endodontics, Dental School, Shiraz University of Medical
Sciences, Shiraz, Iran;; Pharmaceutical Sciences Research Center, Shiraz University
of Medical Sciences, Shiraz, Iran;; Department of Endodontics, Dental School,
Shiraz University of Medical Sciences, Shiraz, Iran;; Students' Research Committee,
Dental School, Shiraz University of Medical Sciences, Shiraz, Iran;; Students'
Research Committee, Dental School, Shiraz University of Medical Sciences, Shiraz,
Iran;; Pharmaceutical Sciences Research Center, Shiraz University of Medical
Sciences, Shiraz, Iran;; Central Laboratory, Shiraz University of Medical Science,
Shiraz, Iran.; Pharmaceutical Sciences Research Center, Shiraz University of
Medical Sciences, Shiraz, Iran;
PY - 2016
SN - 1735-7497 (Print)
SP - 44-50
ST - Antimicrobial and Cytotoxic Activity of Cuminum Cyminum as an Intracanal
Medicament Compared to Chlorhexidine Gel
T2 - Iranian endodontic journal
TI - Antimicrobial and Cytotoxic Activity of Cuminum Cyminum as an Intracanal
Medicament Compared to Chlorhexidine Gel
VL - 11
ID - 14205
ER -
TY - JOUR
AB - A smart drug delivery system for localized controlled release of the broad
spectrum antimicrobial agent, Gemifloxacin Mesylate (GM) following insertion into
the periodontal pocket was developed using the thermosensetive polymer, poloxamer
407 and the ion activated polymer, gellan gum. Many drugs do not reach the site of
action in the therapeutic concentrations intended. So, in the present study, works
have been done for administering the drug directly to the target site so that the
efficacy of treatment can be improved. This site specific delivery of drug can thus
overcome the problems faced during systemic administration of antimicrobials for
the treatment of chronic periodontitis, where the drug get diluted many times
before it reaches the site of action. This also reduces frequency of administration
and dose size, thereby, improves patient compliance and minimizes systemic side
effects. GM in situ gels were prepared by different concentrations of polymers and
evaluated for physical appearance, drug content uniformity, syringeability,
rheological properties, pH, gelation time, gelation temperature, in vitro gelling
capacity and in vitro drug release. Drug excipients compatibility study was done by
FTIR. Results showed no evidence of interaction between the drug and excipients.
The selected formulation was clinically tested and the results revealed that, GM in
situ gel (Containing 18% w/w poloxamer 407 and 0.8% w/w gellan gum) showed
reasonable in vitro results and good clinical improvement.
AN - rayyan-563560344
AU - Abdelgawad, W. Y.
AU - Mohamed, M. I.
AU - Gad, M. K.
AU - Ahmed, E.
IS - 1
KW - gemifloxacin
adult
analytical parameters
article
chronic periodontitis
clinical article
controlled study
drug content uniformity
drug dosage form
drug formulation
female
flow kinetics
gelation temperature
gelation time
human
in situ gel
infrared spectroscopy
male
pH
physical appearance
physical chemistry
syringeability
LA - English
PY - 2016
SN - 0976-044X
SP - 78-85
ST - Formulation, evaluation and clinical assessment of Gemifloxacin in situ gel
for the treatment of chronic periodontitis
T2 - Int. J. Pharm. Sci. Rev. Res.
TI - Formulation, evaluation and clinical assessment of Gemifloxacin in situ gel
for the treatment of chronic periodontitis
VL - 38
ID - 13718
ER -
TY - JOUR
AB - Background & Aim: Periodontal regenerative therapy with bonesubstituting
materials has gained favourable clinical value by enhancing osseous regeneration in
periodontal bony defects. Such materials should fulfil several requirements for
example biocompatibility, osteogenesis, malleability and biodegradability.
Biodegradable polymeric hydrogels, with the capacity to absorb water, are
particularly attractive as vehicles and temporary scaffolds for cells in bone
tissue engineering. This work aimed to design biodegradable bioactive hydrogel
templates of organic-inorganic composites combined with the controlled release of
melatonin for periodontal bone regeneration in an injectable form. Methods: In this
work, we have successfully prepared and characterized a composite hydrogel scaffold
composed of alginate-chitosan/ nano-sized beta-tricalcium phosphate (Alg-CH/β-TCP).
The scaffold was characterized morphologically, structurally, rheologically and
loaded with melatonin. Evaluation of periodontal regenerative potential was
achieved by histomorphometric analysis using acute critical sized periodontal grade
- II furcation defects in a canine model. The study was carried out in accordance
with the Alexandria University, Faculty of Dentistry's ethical standards for using
laboratory animals in science and conformed with ARRIVE guidelines. Results: The
composite scaffold was hydrophilic, showed smooth injectability and SEM images
showed a porosity of over 80%. Histological results showed slight acceleration in
bone formation, nonetheless, the degree of bone maturity was higher in melatonin
group; fully developed new compact alveolar bone showing outer smooth regular
border and inner narrow bone marrow was formed. A significant twofold increase in
height of newly formed inter-radicular bone in relation to defect length at 4 weeks
post-operatively in the melatonin group was seen in comparison to Alg-CH/β-TCP
group. Conclusions: In conclusion, the tested melatonin loaded hydrogel showed
promising results in the management of grade II periodontal furcation defects. Both
hydrogels showed increased bone formation compared to the control group. Moreover,
melatonin loaded hydrogel accelerated the rate of formation and enhanced the
quality of newly formed bone.
AN - rayyan-563559838
AU - Abdelrasoul, M.
AU - Abd El-Fattah, A.
AU - Kotry, G.
AU - Ramadan, O.
AU - Essawy, M.
AU - Kamaldin, J.
AU - Kandil, S.
DO - 10.1111/jcpe.13635
KW - calcium phosphate
hydrogel
melatonin
nanochain
acceleration
alveolar bone
bone marrow
bone regeneration
canine model
conference abstract
controlled study
dentistry
histology
histopathology
human tissue
hydrophilicity
maturity
nonhuman
ossification
periodontal disease
polymerization
porosity
practice guideline
LA - English
PY - 2022
SN - 1600-051X
SP - 113-114
ST - Regeneration of grade II furcation using novel polymeric hydrogel templates
T2 - J. Clin. Periodontol.
TI - Regeneration of grade II furcation using novel polymeric hydrogel templates
VL - 49
ID - 13212
ER -
TY - JOUR
AB - Background: Periodontal regenerative therapy using bone-substituting
materials has gained favorable clinical significance in enhancing osseous
regeneration. These materials should be biocompatible, osteogenic, malleable, and
biodegradable. This study assessed the periodontal regenerative capacity of a novel
biodegradable bioactive hydrogel template of organic–inorganic composite loaded
with melatonin. Materials and methods: A melatonin-loaded alginate-chitosan/beta-
tricalcium phosphate composite hydrogel was successfully prepared and
characterized. Thirty-six critical-sized bilateral class II furcation defects were
created in six Mongrel dogs, and were randomly divided and allocated to three
cohorts; sham, unloaded composite, and melatonin-loaded. Periodontal regenerative
capacity was evaluated via histologic and histomorphometric analysis. Results:
Melatonin-treated group showed accelerated bone formation and advanced maturity,
with a significant twofold increase in newly formed inter-radicular bone compared
with the unloaded composite. The short-term regenerative efficacy was evident 4
weeks postoperatively as a significant increase in cementum length concurrent with
reduction of entrapped epithelium. After 8 weeks, the scaffold produced a quality
of newly synthesized bone similar to normal compact bone, with potent periodontal
ligament attachment. Conclusions: Melatonin-loaded hydrogel template accelerated
formation and enhanced quality of newly formed bone, allowing complete periodontal
regeneration. Furthermore, the scaffold prevented overgrowth and entrapment of
epithelial cells in furcation defects.
AN - rayyan-563559921
AU - Abdelrasoul, M.
AU - El-Fattah, A. A.
AU - Kotry, G.
AU - Ramadan, O.
AU - Essawy, M.
AU - Kamaldin, J.
AU - Kandil, S.
DO - 10.1111/odi.14314
KW - animal cell
animal experiment
animal tissue
article
cell culture
cortical bone
drug efficacy
drug therapy
epithelium cell
histology
maturity
mongrel dog
nonhuman
ossification
periodontal disease
periodontal ligament
regeneration
tooth cementum
calcium phosphate
hydrogel
melatonin
LA - English
PY - 2022
SN - ["1601-0825", "1354-523X"]
ST - Regeneration of critical-sized grade II furcation using a novel injectable
melatonin-loaded scaffold
T2 - Oral Dis.
TI - Regeneration of critical-sized grade II furcation using a novel injectable
melatonin-loaded scaffold
ID - 13295
ER -
TY - JOUR
AB - Objective Herbal therapies are utilized to treat a broad diversity of
diseases all over the globe. Although no clinical studies have been conducted to
demonstrate the antibacterial, antimicrobial, and antiplaque characteristics of
these plants, this does not imply that they are ineffectual as periodontal
treatments or anti-cariogenic drugs. However, there is a scarcity of research
confirming their efficacy and worth. Subject Herbs are utilized in dentistry as
antimicrobial, antineoplastic, antiseptic, antioxidant, and analgesics agents as
well as for the elimination of bad breath. In addition, the application of herbal
agents in tissue engineering improved the regeneration of oral and dental tissues.
This study reviews the application of medicinal herbs for the treatment of dental
and oral diseases in different aspects. Methods This article focuses on current
developments in the use of medicinal herbs and phytochemicals in oral and dental
health. An extensive literature review was conducted via an Internet database,
mostly PubMed. The articles included full-text publications written in English
without any restrictions on a date. Conclusion Plants have been suggested, as an
alternate remedy for oral-dental problems, and this vocation needs long-term
dependability. More research on herbal medicine potential as pharmaceutical sources
and/or therapies is needed.
AN - rayyan-563562534
AU - Abdolahinia, E. D.
AU - Hajisadeghi, S.
AU - Banan, Z. M.
AU - Dadgar, E.
AU - Delaramifar, A.
AU - Izadian, S.
AU - Sharifi, S.
AU - Dizaj, S. M.
DO - 10.1111/odi.14276
PY - 2022
SN - ["1354-523X", "1601-0825"]
ST - Potential applications of medicinal herbs and phytochemicals in oral and
dental health: Status quo and future perspectives
T2 - ORAL DISEASES
TI - Potential applications of medicinal herbs and phytochemicals in oral and
dental health: Status quo and future perspectives
Y2 - 6 y3 - 26
ID - 15908
ER -
TY - JOUR
AB - Tannerella forsythia, a gram-negative fusiform rod, is implicated in several
types of oral anaerobic infections. Most gram-negative bacteria have OmpA-like
proteins that are homologous to the OmpA protein in Escherichia coli. We identified
an OmpA-like protein in T. forsythia encoded by the tf1331 gene as one of the major
proteins by mass spectrometric analysis. Two-dimensional, diagonal electrophoresis
showed that the OmpA-like protein formed a dimeric or trimeric structure via
intermolecular disulfide bonds. A biotin labeling experiment revealed that a
portion of the protein was exposed on the cell surface, even though T. forsythia
possesses an S-layer at the outermost cell surface. Using a tf1331-deletion mutant,
we showed that the OmpA-like protein affected cell morphology. The length of the
mutant cell was reduced almost by half. Cell swelling was observed in more than 40%
of the mutant cells. Moreover, the mutant exhibited decreased adhesion to
fibronectin, retarded autoaggregation, and reduced cell surface hydrophobicity.
These results suggest that the OmpA-like protein in T. forsythia plays an important
role in cellular integrity and adhesive function. © 2011 John Wiley & Sons A/S.
AN - rayyan-563560571
AU - Abe, T.
AU - Murakami, Y.
AU - Nagano, K.
AU - Hasegawa, Y.
AU - Moriguchi, K.
AU - Ohno, N.
AU - Shimozato, K.
AU - Yoshimura, F.
DO - 10.1111/j.2041-1014.2011.00625.x
IS - 6
KW - ampicillin
bacitracin
bacterial protein
biotin
chloramphenicol
dimer
erythromycin
fibronectin
ofloxacin
oligomer
outer membrane protein A like protein
tetracycline
unclassified drug
vancomycin
antibiotic sensitivity
article
bacterial cell
bacterial gene
bacterial strain
bacterium adherence
bacterium mutant
biofilm
cell aggregation
cell shape
cell surface
cell swelling
chemical labeling
controlled study
deletion mutant
disulfide bond
hydrophobicity
matrix assisted laser desorption ionization time of flight mass spectrometry
microscopy
minimum inhibitory concentration
nonhuman
polymerization
protein analysis
protein function
protein structure
sequence alignment
structure analysis
Tannerella forsythia
temperature sensitivity
two dimensional gel electrophoresis
Western blotting
wild type
LA - English
PY - 2011
SN - ["2041-1006", "2041-1014"]
SP - 374-387
ST - OmpA-like protein influences cell shape and adhesive activity of Tannerella
forsythia
T2 - Mol. Oral Microbiol.
TI - OmpA-like protein influences cell shape and adhesive activity of Tannerella
forsythia
VL - 26
ID - 13945
ER -
TY - JOUR
AN - rayyan-563561201
AU - Abello Moreno, R.
IS - 124
KW - chlorhexidine
article
evaluation study
gel
human
periodontal disease
wound healing
LA - Spanish
PY - 1978
SN - 0046-354X
SP - 34-37
ST - Clinical evaluation of chlorhexidine in the form of gel. I
T2 - Valoracion clinica con la clorhexidina en forma de gel. (Primera parte).
TI - Clinical evaluation of chlorhexidine in the form of gel. I
VL - 24
ID - 14575
ER -
TY - JOUR
AB - Background: This study evaluated the inhibitory activity of triphala on PMN-
type matrix metalloproteinase (MMP-9) expressed in adult periodontitis patients and
compared its activity with another ayurvedic drug, kamillosan, and doxycycline,
which has known inhibitory activity. Methods: Matrix metalloproteinases (MMPs) were
extracted from gingival tissue samples from 10 patients (six males, four females)
with chronic periodontitis. Tissue extracts were treated with the drug solutions,
the inhibition was analyzed by gelatin zymography, and the percentage of inhibition
was determined by a gel documentation system. Results: The activity of MMPs was
significantly decreased with the use of the drugs. Triphala showed a 76.6%
reduction of MMP-9 activity, whereas kamillosan showed a 46.36% reduction at a
concentration of 1,500 μg/ml (crude extract) and doxycycline showed a 58.7%
reduction at a concentration of 300 μg/ml (pure drug). Conclusion: The present
study showed the strong inhibitory activity of triphala on PMN-type MMPs involved
in the extracellular matrix (ECM) degradation during periodontitis.
AN - rayyan-563560847
AU - Abraham, S.
AU - Kumar, M. S.
AU - Sehgal, P. K.
AU - Nitish, S.
AU - Jayakumar, N. D.
DO - 10.1902/jop.2005.76.4.497
IS - 4
KW - ayurvedic drug
collagenase
doxycycline
gelatinase B
kamillosan
matrix metalloproteinase inhibitor
metalloproteinase inhibitor
unclassified drug
adult
article
clinical article
concentration (parameter)
controlled study
drug mechanism
enzyme activity
enzyme inhibition
female
gingivitis
human
human tissue
male
periodontitis
statistical analysis
statistical significance
triphala
zymography
LA - English
PY - 2005
SN - 0022-3492
SP - 497-502
ST - Evaluation of the inhibitory effect of triphala on PMN-type matrix
metalloproteinase (MMP-9)
T2 - J. Periodontol.
TI - Evaluation of the inhibitory effect of triphala on PMN-type matrix
metalloproteinase (MMP-9)
VL - 76
ID - 14221
ER -
TY - JOUR
AB - The aim of the work was to study the experience of using complex
pharmacotherapy in the treatment of mandibular fractures in elderly patients with
incomplete secondary periodontitis, which were divided into two groups. In the
first group, patients (n = 46; average age 69.0 ± 3.6) were treated using the
authors' original device combined with application of antimicrobial MetrogilDenta
gel onto gums two times a day during ten days. Patients in the second group (n =
52; average age 61.0 ± 3.1) were treated with the same device combined with (i)
application of MetrogilDenta antimicrobial gel onto gums two times a day during ten
days, (ii) application of 1.5 ml of Cycloferon 5% liniment by cotton pellet for 20
min during the same 10 days (30 minutes after the antimicrobial gel), and (iii)
intramuscular injections of 6 mg of synthetic immunomodulator Polyoxidonium once a
day for 3 days, then once every two days (for a total of 17 days). It is
established that the use of the combination of interferon inducers of
immunomodulator group--Cycloferon in the form of liniment and synthetic
immunomodulator Polyoksidonium together with MetrogilDenta antimicrobial gel--led
to the most pronounced regression of inflammatory and destructive processes in
periodontal tissues (in 7.1%, đ = 0.05), optimized the state of local immunity of
the oral cavity, and normalized microflora in periodontal pockets in elderly
patients with incomplete secondary adentia.
AN - rayyan-563561440
AU - Abramov, A. V.
AU - Parfenov, S. A.
AU - Belov, V. G.
AU - Parfenov Iu, A.
IS - 9
J2 - Eksp Klin Farmakol
KW - Acridines/*therapeutic use
Administration, Topical
Aged
Drug Administration Schedule
Female
Gels
Humans
Immunologic Factors/*therapeutic use
Injections, Intramuscular
Interferon Inducers/*therapeutic use
Male
Mandibular Fractures/complications/*drug therapy/immunology/pathology
Middle Aged
Periodontitis/complications/*drug therapy/immunology/pathology
Piperazines/*therapeutic use
Polymers/*therapeutic use
Tooth Loss/complications/*drug therapy/immunology/pathology
Treatment Outcome
LA - rus
PY - 2014
SN - 0869-2092 (Print)
SP - 23-7
ST - [Application of immunomodulators in the treatment of mandibular fractures in
elderly patients with incomplete secondary adentia]
T2 - Eksperimental'naia i klinicheskaia farmakologiia
TI - [Application of immunomodulators in the treatment of mandibular fractures in
elderly patients with incomplete secondary adentia]
VL - 77
ID - 14814
ER -
TY - JOUR
AB - The aim of the work was to study the experience of using complex
pharmacotherapy in the treatment of mandibular fractures in elderly patients with
incomplete secondary periodontitis, which were divided into two groups. In the
first group, patients (n = 46; average age 69.0 ± 3.6) were treated using the
authors' original device combined with application of antimicrobial MetrogilDenta
gel onto gums two times a day during ten days. Patients in the second group (n =
52; average age 61.0 ± 3.1) were treated with the same device combined with (i)
application of MetrogilDenta antimicrobial gel onto gums two times a day during ten
days, (ii) application of 1.5 ml of Cycloferon 5 % liniment by cotton pellet for 20
min during the same 10 days (30 minutes after the antimicrobial gel), and (iii)
intramuscular injections of 6 mg of synthetic immunomodulator Polyoxidonium once a
day for 3 days, then once every two days (for a total of 17 days). It is
established that the use of the combination of interferon inducers of
immunomodulator group - Cycloferon in the form of liniment and synthetic
immunomodulator Polyoksidonium together with MetrogilDenta antimicrobial gel - led
to the most pronounced regression of inflammatory and destructive processes in
periodontal tissues (in 7.1 %, d = 0.05), optimized the state of local immunity of
the oral cavity, and normalized microflora in periodontal pockets in elderly
patients with incomplete secondary adentia.
AN - rayyan-563560457
AU - Abramov, A. V.
AU - Parfenov, S. A.
AU - Belov, V. G.
AU - Parfenov, Yu A.
IS - 9
azoximer bromide
cycloferon
immunomodulating agent
unclassified drug
aged
article
gel
human
immunity
incomplete secondary periodontitis
inflammation
liniment
major clinical study
mandible fracture
microflora
mouth cavity
periodontal pocket
periodontitis
treatment duration
LA - Russian
PY - 2014
SN - 0869-2092
SP - 23-27
ST - Application of immunomodulators in the treatment of mandibular fractures in
elderly patients with incomplete secondary adentia
T2 - Eksp. Klinicheskaya Farmakol.
TI - Application of immunomodulators in the treatment of mandibular fractures in
elderly patients with incomplete secondary adentia
VL - 77
ID - 13831
ER -
TY - JOUR
AB - This research was conducted to appear the effectiveness of milkfish scales
chitosan gel (Chanos Chanos) against bacterial inhibition of Aggregatibacter
actinomycetemcomitans and Porphyromonas gingivalis which are pathogenic bacteria
that cause periodontitis. This research was conducted with five treatments with
five repetitions, the five treatments, namely: Positive control (metronidazole),
negative control (aquadest), chitosan gel in milkfish scales concentration of 1%,
5%, and 10%. Measuring instrument of this research uses calipers with denominations
of millimeters (mm). Based on the results of the Mann Whitney test, there was a
significant difference in inhibition of chitosan gel on the scale of milkfish 1%,
5%, and 10% against the Aggregatibacter actinomycetemcomitans & Porphyromonas
gingivalis gel (p <0.005), and based on the Kruskal Wallis test, it was found that
the higher concentration of gel milkfish scales, the higher the average inhibition
power. It was concluded that milkfish scales gel chitosan (Chanos chanos) can
inhibit the growth of Aggregatibacter actinomycetemcomitans & Porphyromonas
gingivalis and the higher the concentration of chitosan gel in milkfish scales, the
higher the inhibition zone produced.
AN - rayyan-563560116
AU - Achmad, H.
AU - Djais, A. I.
AU - Jannah, M.
AU - Carmelita, A. B.
AU - Uinarni, H.
AU - Arifin, E. M.
AU - Huldani
AU - Putra, A. P.
DO - 10.31838/srp.2020.6.121
IS - 6
KW - aquadest
chitosan
gel
metronidazole
unclassified drug
Aggregatibacter actinomycetemcomitans
animal experiment
animal structures
article
concentration process
controlled study
fish
growth inhibition
Kruskal Wallis test
milkfish scale
nonhuman
periodontitis
Porphyromonas gingivalis
priority journal
rank sum test
zone of inhibition
LA - English
PY - 2020
SN - ["0976-2779", "0975-8453"]
SP - 836-841
ST - Antibacterial chitosan of milkfish scales (Chanos chanos) on bacteria
prophyromonas gingivalis & agregatibacter actinomycetemcomitans
T2 - Syst. Rev. Pharm.
TI - Antibacterial chitosan of milkfish scales (Chanos chanos) on bacteria
VL - 11
ID - 13490
ER -
TY - JOUR
AN - rayyan-563561711
AU - Achmad, H.
AU - Djais, A. I.
AU - Jannah, M.
AU - Carmelita, A. B.
AU - Uinarni, H.
AU - Arifin, E. M.
AU - Putra, A. P.
DO - 10.31838/srp.2020.6.121
IS - 6
PY - 2020
SP - 836-841
ST - Antibacterial chitosan of milkfish scales (Chanos chanos) on bacteria
T2 - Systematic Reviews in Pharmacy
TI - Antibacterial chitosan of milkfish scales (Chanos chanos) on bacteria
85089430783&doi=10.31838%2fsrp.2020.6.121&partnerID=40&md5=3317e8a1058702803b821daf
525e722f
VL - 11
ID - 15085
ER -
TY - JOUR
AB - Bacterial infections in the mouth are caused mainly by the normal endogenous
flora and are rarely of exogenous origins. The bacteria may play a primary
aetiological role in disease or be secondary contaminators of disease caused by
other pathogenic mechanisms. Antibacterial agents used topically are logical in the
management of some of these infections and could be used for prevention or therapy.
In both situations a variety of delivery methods has been proposed and can
conveniently be classified according to duration of delivery as: short, medium and
long-term. Most interest in antibacterial agents has been in the control of plaque-
related diseases, particularly chronic gingivitis. Effective compounds show
persistence of action for many hours, notably chlorhexidine. Chemical plaque
control agents are of limited therapeutic value and are more valuable in the
preventive mode. Such agents also are of no value in the treatment of chronic
periodontitis unless delivered directly into pockets by irrigation or sustained-
delivery vehicles. In fact, even by irrigation, antibacterials appear to offer
limited action above that of a washing-out effect. Sustained delivery vehicles are
relatively numerous, but it is the antibacterial rather than the vehicle which
appears important. Most data are available for chlorhexidine, metronidazole and
tetracycline, with again chlorhexidine appearing of little value in a therapeutic
mode. Despite encouraging results for metronidazole and tetracycline, more data are
required demonstrating lasting adjunctive benefits of local antibacterials to
conventional mechanical treatments. Despite the logic behind the use of topical
antibacterials for oral infections, many prescribed uses are somewhat empirical and
more controlled studies are required.
AN - rayyan-563562365
AU - Addy, M.
DO - 10.1016/0169-409X(94)90029-9
IS - 1
PY - 1994
SN - ["0169-409X", "1872-8294"]
SP - 123-134
ST - LOCAL-DELIVERY OF ANTIMICROBIAL AGENTS TO THE ORAL CAVITY
T2 - ADVANCED DRUG DELIVERY REVIEWS
TI - LOCAL-DELIVERY OF ANTIMICROBIAL AGENTS TO THE ORAL CAVITY
VL - 13
Y2 - 1
ID - 15739
ER -
TY - JOUR
AN - rayyan-563561212
AU - Addy, M.
AU - Douglas, W. H.
DO - 10.1902/jop.1975.46.8.465
IS - 8
KW - alcohol
chlorhexidine
coe pack
phthalic acid dibutyl ester
polyacrylic acid
unclassified drug
zinc oxide
mouth mucosa
periodontium
therapy
LA - English
PY - 1975
SN - 0022-3492
SP - 465-468
ST - A chlorhexidine containing methacrylic gel as a periodontal dressing
T2 - J. PERIODONTOL.
TI - A chlorhexidine containing methacrylic gel as a periodontal dressing
VL - 46
ID - 14586
ER -
TY - JOUR
AB - Periodontal disease appears to arise from the interaction of pathogenic
bacteria with a susceptible host. The main aims of disease management have been to
establish a high standard of oral hygiene and to professionally and thoroughly
debride the root surface. Chemical agents could be considered for both aspects of
management. Chemoprevention using supragingivally delivered agents such as
chlorhexidine may be questioned for value in the pre-treatment hygiene phase but
have well-established efficacy immediately preoperatively and during the
postoperative weeks. Long-term maintenance use of chlorhexidine is problematic due
to local side effects. Antiplaque toothpastes show modest benefits to gingivitis
but are not proven to prevent recurrence of periodontitis. Chemotherapy may be
directed at subgingival plaque, using antimicrobials, or at the host response using
anti-inflammatory agents. Antimicrobials can be locally or systemically delivered.
In most cases antimicrobial chemotherapy should be considered adjunctive to
mechanical debridement. The advantages of local and systemic chemotherapy must be
balanced against the disadvantages and potential side effects of agents.
Antimicrobial chemotherapy offers little or no benefit to the treatment of most
chronic adult periodontitis patients and should be reserved for the more rapid or
refractory types of disease, and after the debridement phase. Despite the large
number of studies there are insufficient comparative data to support any one local
delivery system or systemic regimen as superior to another. Systemic versus local
antimicrobials have not been compared to date. Host response modifying drugs such
as non-steriodal antiinflammatory drugs (NSAIDs) offer the potential to reduce
breakdown and promote healing, including bone regeneration. However until more data
are available, NSAIDs should not be used in the management of chronic periodontal
diseases, there being no specific agent(s) or regimen established for use.
Chemotherapy has an important place in the management of chronic periodontal
diseases but routine use must be considered as an over prescription of these
valuable agents.
AN - rayyan-563562419
AU - Addy, M.
AU - RentonHarper, P.
DO - 10.1111/j.1365-2842.1996.tb00845.x
IS - 4
PY - 1996
SN - 0305-182X
SP - 219-231
ST - Local and systemic chemotherapy in the management of periodontal disease: An
opinion and review of the concept
T2 - JOURNAL OF ORAL REHABILITATION
TI - Local and systemic chemotherapy in the management of periodontal disease: An
opinion and review of the concept
VL - 23
Y2 - 4
ID - 15793
ER -
TY - JOUR
AB - Background/aims: Enterococcus faecalis strains with multiple antibiotic
resistances can cause infections that are difficult to treat. The microbial flora
in treatment-resistant apical periodontitis is dominated by E. faecalis, and is a
potential source of infections at other sites. Material and methods: Sensitivities
to a range of antibiotics were determined for 59 endodontic E. faecalis isolates
from Finland and Lithuania. The DNA sequence of the gene responsible for the
species' intrinsic quinupristin-dalfopristin resistance, lsa, was determined from
two isolates with diminished resistance. Four pairs of isolates from the same root
canal were typed by pulsed-field gel electrophoresis. Results: A high prevalence of
resistance to rifampicin was found, whereas all isolates were susceptible or showed
intermediate susceptibility to penicillin and ampicillin and four isolates were
unusually susceptible to cefotaxime. No vancomycin or high-level gentamicin
resistance was detected. Nine of 59 isolates were susceptible to quinupristin-
dalfopristin. A fully quinupristin-dalfopristin-susceptible isolate also
susceptible to clindamycin produced a truncated Lsa polypeptide, and an isolate
with borderline quinupristin-dalfopristin-susceptibility had mutations proximal to
the predicted ribosomal binding site. Pulsed-field gel electrophoresis showed that
the same root canal could harbor two different strains of E. faecalis during the
course of the same infection. Conclusion: Despite the differing antibiotic usage in
Finland and Lithuania, E. faecalis from endodontic infections in these countries
showed similar susceptibility patterns with levels of resistance considered typical
for the species, and decreased resistance to clindamycin and quinupristin-
dalfopristin as well as lesions in the lsa gene which were similar to those
described in other clinical isolates.
AN - rayyan-563562452
AU - af Geijersstam, A. H. R.
AU - Ellington, M. J.
AU - Warner, M.
AU - Woodford, N.
AU - Haapasalo, M.
DO - 10.1111/j.1399-302X.2006.00271.x
IS - 3
PY - 2006
SN - 0902-0055
SP - 164-168
ST - Antimicrobial susceptibility and molecular analysis of Enterococcus faecalis
originating from endodontic infections in Finland and Lithuania
T2 - ORAL MICROBIOLOGY AND IMMUNOLOGY
TI - Antimicrobial susceptibility and molecular analysis of Enterococcus faecalis
VL - 21
Y2 - 6
ID - 15826
ER -
TY - JOUR
AB - The aim of this study was to evaluate the efficacy of topical subgingival
application of doxycycline hyclate (DH) gel adjunctive to non-surgical periodontal
therapy on gingival crevicular fluid (GCF) matrix metalloproteinase (MMP)-8 levels
in chronic and aggressive periodontitis patients. Forty teeth of 10 chronic
periodontitis patients and 32 teeth of eight aggressive periodontitis patients were
screened for 6 months. Scaling and root planing (SRP) was applied to the control
sites and DH gel adjunctive to SRP was applied to the test sites of each patient
simultaneously. GCF MMP-8 levels were analysed at baseline, 7 days; and at 1, 3 and
6 months by Sandwich Elisa Method. At 1, 3 and 6 months, probing depth (P < 0.0051)
and plaque scores and bleeding on probing values (P = 0.000) significantly
decreased in each group when compared with the baseline, but there was no
statistically significant difference between the test and control sites. GCF MMP-8
levels reduced presenting statistically significant differences on 7 days, 1, 3 and
6 months in four of the groups (P < 0.05); however, intergroup differences were not
statistically significant. Developing functional and immunological-based chair-side
MMP tests might serve as useful adjunctive diagnostic tools when monitoring the
effects of DH gel application.
AN - rayyan-563560766
AU - Agan, S.
AU - Sönmez, S.
AU - Serdar, M.
DO - 10.1111/j.1601-5037.2006.00174.x
IS - 3
KW - doxycycline
doxycycline hyclate
drug derivative
neutrophil collagenase
topical antiinfective agent
acute disease
adult
aged
analysis of variance
article
chronic disease
clinical trial
controlled clinical trial
controlled study
delayed release formulation
enzymology
female
gel
gingivitis
human
male
middle aged
nonparametric test
periodontitis
pilot study
preventive dentistry
randomized controlled trial
single blind procedure
LA - English
PY - 2006
SN - 1601-5029
SP - 114-121
ST - The effect of topical doxycycline usage on gingival crevicular fluid MMP-8
levels of chronic and aggressive periodontitis patients: a pilot study
T2 - Int J Dent Hyg
TI - The effect of topical doxycycline usage on gingival crevicular fluid MMP-8
levels of chronic and aggressive periodontitis patients: a pilot study
VL - 4
ID - 14140
ER -
TY - JOUR
AB - BACKGROUND: Several epidemiologic studies have identified a greater incidence
of periodontitis in patients with type 2 diabetes. Recent developments suggest that
local delivery of antimicrobials into periodontal pockets improve periodontal
health. The present study is designed to investigate the adjunctive effects of
subgingivally delivered azithromycin (AZM; 0.5% concentration) as an adjunct to
scaling and root planing (SRP) for treating chronic periodontitis in patients with
type 2 diabetes. METHODS: A total of 63 patients were categorized into two
treatment groups: 1) group 1: SRP + placebo gel and 2) group 2: SRP + 0.5% AZM.
Clinical parameters were recorded at baseline and 3, 6, and 9 months; they included
modified sulcus bleeding index (mSBI), plaque index (PI), probing depth (PD), and
clinical attachment level (CAL). RESULTS: Both therapies resulted in significant
improvements. Using a patient-based analysis, patients in group 2 treated with SRP
+ 0.5% AZM showed enhanced reductions in PI, GI, mSBI, and PD and gains in CAL (P
<0.05) over 9 months compared with group 1. CONCLUSION: Although both treatment
strategies seem to benefit the patients, the adjunctive use of 0.5% AZM as a
controlled drug delivery system enhances the clinical outcome.
AN - rayyan-563560279
AU - Agarwal, E.
AU - Bajaj, P.
AU - Naik, S. B.
AU - Pradeep, A. R.
DO - 10.1902/jop.2012.120172
IS - 12
azithromycin
adult
complication
controlled study
dental scaling
double blind procedure
female
gingivitis
human
male
middle aged
mucosal drug administration
multimodality cancer therapy
non insulin dependent diabetes mellitus
pathology
plaque index
procedures
root planing
LA - English
PY - 2017
SN - 1943-3670
SP - 1281-1287
ST - Locally Delivered 0.5% Azithromycin as an Adjunct to Non-Surgical Treatment
in Patients With Chronic Periodontitis With Type 2 Diabetes: A Randomized
Controlled Clinical Trial
TI - Locally Delivered 0.5% Azithromycin as an Adjunct to Non-Surgical Treatment
in Patients With Chronic Periodontitis With Type 2 Diabetes: A Randomized
VL - 88
ID - 13653
ER -
TY - JOUR
AB - Background: The relationship between cigarette smoking and periodontal
disease has been examined extensively. Local delivery of antimicrobials into
periodontal pockets improves periodontal health. The present study is designed to
investigate the adjunctive effects of subgingivally delivered 0.5% clarithromycin
(CLM) as an adjunct to scaling and root planing for treating chronic periodontitis
in smokers. Methods: Sixty-one patients were randomized and categorized into two
treatment groups: group 1, in which 31 individuals received scaling and root
planing plus 0.5% CLM, and group 2, in which 30 individuals received scaling and
root planing plus placebo gel. Clinical parameters were recorded at baseline and at
1, 3, and 6 months; they included plaque index (PI), modified sulcus bleeding index
(mSBI), gingival index (GI), probing depth (PD), and clinical attachment level
(CAL). The mean concentration of 0.5% CLM in gingival crevicular fluid (GCF) was
estimated by reverse-phase high-performance liquid chromatography. Results: Both
therapies resulted in significant improvements. At the end of 6 months, the mean
GI, PI, mSBI, PD, and CAL for the CLM group were 1.06 ± 0.28, 2.82 ± 0.64, 1.36 ±
0.24, 4.64 ± 0.63, and 4.90 ± 0.46, respectively, versus 1.38 ± 0.41, 3.22 ± 0.57,
1.44 ± 0.27, 6.07 ± 0.88, and 5.69 ± 0.46, respectively, for the placebo group.
Using an individual-based analysis, individuals in group 1 showed enhanced clinical
outcome (P <0.05) over a period of 6 months compared with those in group 2. CLM was
detected in GCF until a period of 7 weeks after the local drug delivery.
Conclusion: Although both treatment strategies seemed to benefit the individuals,
the adjunctive use of 0.5% CLM as a controlled drug delivery system enhanced the
clinical outcome.
AN - rayyan-563560530
AU - Agarwal, E.
AU - Pradeep, A. R.
AU - Bajaj, P.
AU - Naik, S. B.
DO - 10.1902/jop.2012.110600
IS - 9
clarithromycin
placebo
adult
article
chemistry
comparative study
controlled study
follow up
gel
gingiva bleeding
gingivitis
human
male
methodology
middle aged
periodontal disease
periodontal pocket
periodontics
smoking
tooth plaque
treatment outcome
LA - English
PY - 2012
SN - 0022-3492
SP - 1155-1163
ST - Efficacy of local drug delivery of 0.5% clarithromycin gel as an adjunct to
non-surgical periodontal therapy in the treatment of current smokers with chronic
periodontitis: A randomized controlled clinical trial
TI - Efficacy of local drug delivery of 0.5% clarithromycin gel as an adjunct to
non-surgical periodontal therapy in the treatment of current smokers with chronic
periodontitis: A randomized controlled clinical trial
VL - 83
ID - 13904
ER -
TY - JOUR
AB - Protein and peptide macromolecules have emerged as promising therapeutic
agents in recent years. However, their delivery to the target site can be
challenging owing to their susceptibility to denaturation and degradation, short
half-life and, therefore, poor bioavailability. In situ-forming implants present an
attractive parenteral delivery platform for proteins and peptides because of their
ease of application, sustained-release properties, tissue biocompatibility and
simple manufacture. In this review, we discuss the various mechanisms by which
polymer systems assemble in situ to form implant devices for sustained release of
therapeutic macromolecules, and highlight recent advances in polymer systems that
gel in response to a combination of these mechanisms. Finally, we examine release
mechanisms, marketed products and limitations of injectable implants. © 2013
Elsevier Ltd.
AN - rayyan-563560487
AU - Agarwal, P.
AU - Rupenthal, I. D.
DO - 10.1016/j.drudis.2013.01.013
IS - 7
KW - amylase
bleomycin A5
bupivacaine
cyclosporine
cytoryn
doxycycline
doxycycline hyclate
enzyme
ethinylestradiol
fluorescein isothiocyanate dextran
growth factor
horseradish peroxidase
human growth hormone
insulin
interleukin 2
leuprorelin
lysozyme
paclitaxel
pacligel
peptide
plasmid DNA
polymer
recombinant bone morphogenetic protein 2
risperidone
repaglinide
rivastigmine
rosiglitazone
tissue plasminogen activator
tumor necrosis factor
unclassified drug
clinical trial
cross linking
drug half life
drug release
gel
human
implant
liquid
macromolecule
medical device
periodontitis
pH
precipitation
review
thermal analysis
atridox
doxirobe
eligard
oncogel
posidur
relday
Atridox
Atrigel
BST-Gel
Cytoryn
Doxirobe
Eligard
InGell
Octodex
Oncogel
ReGel
SABER
LA - English
PY - 2013
SN - ["1359-6446", "1878-5832"]
SP - 337-349
ST - Injectable implants for the sustained release of protein and peptide drugs
T2 - Drug Discov. Today
TI - Injectable implants for the sustained release of protein and peptide drugs
VL - 18
ID - 13861
ER -
TY - JOUR
AN - rayyan-563561529
AU - Agarwal, V.
AU - Warikoo, A.
AU - Prakash, P.
AU - Sharma, P.
AU - Pahwa, M.
AU - Alam, F.
DO - 10.37285/ijpsn.2023.16.2.7
IS - 2
PY - 2023
SP - 6445-6452
ST - Ocimum Sanctum: A Herbal Agent for Revivification of Periodontal Health
T2 - International Journal of Pharmaceutical Sciences and Nanotechnology
TI - Ocimum Sanctum: A Herbal Agent for Revivification of Periodontal Health
85164420929&doi=10.37285%2fijpsn.2023.16.2.7&partnerID=40&md5=da43e62e05c8abe661072
a6062d479dc
VL - 16
ID - 14903
ER -
TY - JOUR
AB - Background: Periodontal disease is an immuno-inflammatory condition of
tissues that surround and hold the teeth. It is the disease which succeeds in all
races, groups and both genders. Almost 10 to15% of the global population gets
suffered from severe periodontitis as per WHO reports. Periodontal disease may
likely cause other systemic diseases such as cardiovascular disease and pre-term
low birth weight infants. Mechanical removal of plaques and calculus deposits from
supra and subgingival environment is the backbone of periodontal treatment till
date whereas complete elimination of these deleterious agents is quite unrealistic
as the pocket depth increases. Recent Approaches: Recently controlled local drug
delivery application is more encouraging in comparison to systemic approach as it
mainly targets to enhance the therapeutic efficacy by maintaining site-specificity,
avoiding first pass metabolism, reduction in gastrointestinal (GI) side effects and
decreasing the dose. Several drugs such as antiseptics and antibiotics alongwith
various carriers are being formulated as local drug delivery systems for effective
management of the disease. Various local delivery systems reported are fibers,
films, strips, compacts, injectables, microparticles, vesicular carriers, gels and
nanoparticles. These local carriers provide effective prolonged treatment at the
site of infection at reduced doses. This review enlightens detailed pathophysiology
and various phases of periodontitis, challenges in treatment of disease and various
antimicrobial agents (along with their marketed formulations) used. The main
emphasis of the review is to cover all carrier systems developed so far for local
delivery application in the effective management of periodontitis, as a patient
compliant drug therapy.
AN - rayyan-563560211
AU - Aggarwal, G.
AU - Verma, S.
AU - Gupta, M.
AU - Nagpal, M.
DO - 10.2174/1574885514666190103112855
IS - 2
KW - fiber
film
syringe
alginic acid
atrigel
C reactive protein
cellulose acetate
chitosan
chlorhexidine
chlorhexidine gluconate
chlosite
ciprofloxacin
clarithromycin
collagen
minocycline
diclofenac
doxycycline
doxycycline hyclate
drug carrier
ethyl cellulose
ethylene vinyl acetate copolymer
gelatin
gentamicin
interleukin 1
macrogol
matrix metalloproteinase
metronidazole
nanoparticle
periocol c
poly(3 hydroxybutyric acid)
polycaprolactone
polymer
sanguinarine
tetracycline
unindexed drug
antifungal activity
antimicrobial activity
dental caries
dental health
dental restoration
dental surgery
disease activity
drug release
drug solubility
gastrointestinal symptom
gel
gingivitis
human
hydrogel
membrane microparticle
mouth hygiene
pathophysiology
periodontal disease
periodontal pocket
periodontitis
polymerization
priority journal
review
tooth brushing
tooth calculus
tooth plaque
tooth root
actisite
arestin
atridox
dentomycin
elyzol
periochip
LA - English
PY - 2019
SN - ["1065-7630", "1574-8855"]
SP - 135-152
ST - Local drug delivery based treatment approaches for effective management of
periodontitis
T2 - Curr. Crug Ther.
TI - Local drug delivery based treatment approaches for effective management of
periodontitis
VL - 14
ID - 13585
ER -
TY - JOUR
AB - Antimicrobial properties of platelet rich plasma (PRP) against various
microorganisms have been recently pointed out. PRP could be an alternative to
conventional antibiotics in preventing oral and periodontal infections. We examined
whether PRP has in vitro antimicrobial properties against Aggregatibacter
actinomycetemcomitans, Prophyromonas gingivalis, Staphylococcus aureus and Candida
albicans. PRP and platelet-poor plasma (PPP) were obtained from whole blood of 10
healthy volunteers and 10 periodontitis patients. In vitro laboratory
susceptibility was carried out using the modified agar diffusion method by
measuring the diameters of inhibition zones on agar plates coated with selected
microbial strains. Both calcium chloride (CaC12) activated and non activated
samples were tested. Both activated PRP and PPP, of both patients and controls,
effectively inhibited the growth of A. actinomycetemcomitans, P gingivalis and C.
albicans. However, a statistically significant difference in favor of PRP was found
indicating more susceptibility to PRP than PPP (p <0.05). Non activated PRP and PPP
exhibited negative zones of inhibition against the studied microorganisms. There
was no activity against S. aureus. No statistically significant difference was
found between the antimicrobial effects of PRP and/or PPP obtained from patients
and controls (p > 0.05). We conclude that PRP is a potentially useful substance
against oral and periodontal pathogens. Activated PRP was found to be more active
than activated PPP and the activation of coagulation is a fundamental step.
Additionally, the antimicrobial activity of PRP and/or PPP seems not to be affected
by periodontitis.
AN - rayyan-563562213
AU - Aggour, R. L.
AU - Gamil, L.
DO - 10.5604/17331331.1235227
IS - 1
PY - 2017
SN - 1733-1331
SP - 31-37
ST - Antimicrobial Effects of Platelet-rich Plasma against Selected Oral and
Periodontal Pathogens
T2 - POLISH JOURNAL OF MICROBIOLOGY
TI - Antimicrobial Effects of Platelet-rich Plasma against Selected Oral and
Periodontal Pathogens
VL - 66
ID - 15587
ER -
TY - JOUR
AB - In-situ forming implants (ISFI) which simultaneously release an antimicrobial
and anti-inflammatory drug in a controlled manner offer an interesting potential
for local periodontitis treatment. In this study, poly(lactic-co-glycolic acid)
(PLGA)-based implants loaded with chlorhexidine and ibuprofen were investigated, in
particular with respect to their antimicrobial and mechanical key properties. PLGA
(Resomer RG 502H) was dissolved in N-methyl pyrrolidone (NMP). Chlorhexidine
dihydrochloride and ibuprofen (free acid) were added as well as acetyltributyl
citrate (ATBC) as plasticizer and hydroxypropyl methylcellulose (HPMC, Methocel,
E50) as adhesion enhancer. Upon contact with aqueous fluids, the NMP diffuses out
and water into the formulation, causing polymer precipitation and drug entrapment.
The antimicrobial activity against periodontal pathogens was studied using the
agar-well diffusion test, time-kill studies and growth curve method. The
syringeability of the liquid formulations and mechanical key properties of the in-
situ formed implants were investigated using a texture analyzer. A commercially
available gel used for local periodontitis treatment, loaded with chlorhexidine
dihydrochloride and chlorhexidine digluconate (Chlo-site) was studied for reasons
of comparison. Importantly, the investigated ISFIs showed a strong and rapid
antibacterial activity against all the selected pathogens, while maintaining
suitable mechanical properties. The simultaneous release of ibuprofen did not
reduce the desired antimicrobial effect of chlorhexidine.
AN - rayyan-563560070
AU - Agossa, K.
AU - Delepierre, A.
AU - Lizambard, M.
AU - Delcourt-Debruyne, E.
AU - Siepmann, J.
AU - Siepmann, F.
AU - Neut, C.
DO - 10.1016/j.jddst.2020.101956
KW - 1 methyl 2 pyrrolidinone
acetyltributyl citrate
chlo site
chlorhexidine
ibuprofen
plasticizer
polyglactin
unclassified drug
article
bacterial growth
bacterial infection
bacteriostatic activity
broth dilution
controlled study
drug formulation
Fusobacterium
Fusobacterium naviforme
Fusobacterium nucleatum
growth inhibition
hardness
minimum bactericidal concentration
periodontal pocket
periodontitis
precipitation
Prevotella nigrescens
Streptococcus constellatus
Streptococcus sanguinis
Veillonella
LA - English
PY - 2020
SN - 1773-2247
ST - In-situ forming implants for dual controlled release of chlorhexidine and
ibuprofen for periodontitis treatment: Microbiological and mechanical key
properties
TI - In-situ forming implants for dual controlled release of chlorhexidine and
ibuprofen for periodontitis treatment: Microbiological and mechanical key
properties
VL - 60
ID - 13444
ER -
TY - CONF
AN - rayyan-563562153
AU - Aguirre, A.
AU - Testa-Weintraub, L. A.
AU - Banderas, J. A.
AU - Haraszthy, G. G.
AU - Reddy, M. S.
AU - Levine, M. J.
DA - 1993
DO - 10.1177/10454411930040031201
ET - 3
SP - 343-350
ST - Sialochemistry: A diagnostic tool?
T2 - Critical Reviews in Oral Biology and Medicine
TI - Sialochemistry: A diagnostic tool?
0027304967&doi=10.1177%2f10454411930040031201&partnerID=40&md5=6ec07176f10e3ec8f97d
d73bf2139dbc
VL - 4
ID - 15527
ER -
TY - JOUR
AN - rayyan-563561138
AU - Aguirre, A.
AU - Testa-Weintraub, L. A.
AU - Banderas, J. A.
AU - Haraszthy, G. G.
AU - Reddy, M. S.
AU - Levine, M. J.
DO - 10.1177/10454411930040031201
IS - 3
KW - amino acid
amylase
cystatin
cysteine proteinase
glycoprotein
histatin
immunoglobulin A
lactoferrin
lysozyme
mucin
proline
saliva protein
statherin
adult
aged
antifungal activity
bacterial colonization
chromatography
conference paper
controlled study
dental caries
female
human
human experiment
immunoblotting
male
parotid gland
periodontal disease
saliva
saliva analysis
salivary gland disease
salivation
xerostomia
LA - English
PY - 1993
SN - 1045-4411
SP - 343-350
ST - Sialochemistry: A diagnostic tool?
T2 - CRIT. REV. ORAL BIOL. MED.
TI - Sialochemistry: A diagnostic tool?
VL - 4
ID - 14512
ER -
TY - JOUR
AB - BACKGROUND: Local delivery of antimicrobial agents provides higher
concentration of the drug in the periodontal site for longer periods than
systemically delivered methods. In the present study an attempt is made to know the
efficacy of controlled local drug delivery of doxycycline as an adjunctive
treatment in the management of chronic periodontitis. MATERIALS AND METHODS: A
total of 12 patients, diagnosed as Chronic Periodontitis in the age of 25 to 55
years, were selected of both the sexes in this study. They were divided into
Experimental group consisted of 30 sites who received complete scaling and root
planing (SRP) followed by placement of Atridox gel and control group consisted of
30 sites who received only SRP. Clinical parameters were recorded at, baseline,
days 30, 90 and 180. Parameters were plaque index, gingival index, gingival
bleeding index and microbial analysis, probing pocket depth and Clinical attachment
level (CAL). The microbiological analysis was done at baseline visit and at 90th
day. Probing pocket depth and CAL were recorded only on day 0 and 180th day.
RESULTS: In 180 days study, both the groups exhibited a significant improvement in
periodontal status. Significant gain in attachment level was observed in both the
group. Between both the groups the clinical parameters in the experimental groups
exhibited better results as compared to the control group. Both the groups
exhibited significant reduction in the number of spirochetes. CONCLUSION:
Combination therapy of SRP and 10% DH gel demonstrated better results at all levels
suggesting that this therapy can play a significant role as an adjunct to SRP in
the management of chronic periodontitis.
AN - rayyan-563560467
AU - Ahamed, S.
AU - Jalaluddin, M.
AU - Khalid, I.
AU - Moon, N.
AU - Shaf, T. K.
AU - Ali, F. M.
IS - 6
doxycycline
gel
adult
bacterial load
bacterium
comparative study
tooth plaque
drug effect
female
follow up
human
male
microbiology
middle aged
periodontal disease
periodontal pocket
periodontics
procedures
spirochete
treatment outcome
LA - English
PY - 2013
SN - 1526-3711
SP - 1080-1086
ST - The use of controlled release locally delivered 10% doxycycline hyclate gel
as an adjunct to scaling and root planing in the treatment of chronic
periodontitis: clinical and microbiological results
T2 - J Contemp Dent Pract
TI - The use of controlled release locally delivered 10% doxycycline hyclate gel
VL - 14
ID - 13841
ER -
TY - COMP
AB - BACKGROUND: Local delivery of antimicrobial agents provides higher
concentration of the drug in the periodontal site for longer periods than
systemically delivered methods. In the present study an attempt is made to know the
efficacy of controlled local drug delivery of doxycycline as an adjunctive
treatment in the management of chronic periodontitis. MATERIALS AND METHODS: A
total of 12 patients, diagnosed as Chronic Periodontitis in the age of 25 to 55
years, were selected of both the sexes in this study. They were divided into
Experimental group consisted of 30 sites who received complete scaling and root
planing (SRP) followed by placement of Atridox gel and control group consisted of
30 sites who received only SRP. Clinical parameters were recorded at, baseline,
days 30, 90 and 180. Parameters were plaque index, gingival index, gingival
bleeding index and microbial analysis, probing pocket depth and Clinical attachment
level (CAL). The microbiological analysis was done at baseline visit and at 90th
day. Probing pocket depth and CAL were recorded only on day 0 and 180th day.
RESULTS: In 180 days study, both the groups exhibited a significant improvement in
periodontal status. Significant gain in attachment level was observed in both the
group. Between both the groups the clinical parameters in the experimental groups
exhibited better results as compared to the control group. Both the groups
exhibited significant reduction in the number of spirochetes. CONCLUSION:
Combination therapy of SRP and 10% DH gel demonstrated better results at all levels
suggesting that this therapy can play a significant role as an adjunct to SRP in
the management of chronic periodontitis.
AN - rayyan-563561104
AU - Ahamed, S.
AU - Jalaluddin, M.
AU - Khalid, I.
AU - Moon, N.
AU - Shaf, T. K.
AU - Ali, F. M.
CY - India
DO - 10.5005/jp-journals-10024-1455
ET - 6
J2 - J Contemp Dent Pract
KW - Adult
Anti-Bacterial Agents/administration & dosage/*therapeutic use
Bacteria/drug effects
Bacterial Load/drug effects
Chronic Periodontitis/microbiology/*therapy
Combined Modality Therapy
Delayed-Action Preparations
Dental Plaque/microbiology/therapy
Dental Plaque Index
Dental Scaling/*methods
Doxycycline/administration & dosage/*therapeutic use
Female
Follow-Up Studies
Gels
Humans
Male
Middle Aged
Periodontal Attachment Loss/microbiology/therapy
Periodontal Index
Periodontal Pocket/microbiology/therapy
Root Planing/*methods
Spirochaetales/drug effects
Treatment Outcome
LA - eng
N1 - Associate Professor, Department of Periodontics, Malabar Dental College,
Edapal, Kerala, India, Phone: 9746074655, e-mail: drshabeer9582@gmail.com.; Reader,
Department of Periodontics and Oral Implantology, Kalinga Institute of Dental
Sciences, Bhubaneswar-24, Odisha, India.; Reader, Department of Oral and
Maxillofacial Surgery, MGM Dental College, Navi Mumbai, Maharashtra, India.;
Professor and Head, Department of Periodontics, RKDF Dental College and Research
Centre, Bhopal, Madhya Pradesh, India.; Reader, Department of Periodontics, Kannur
Dental College, Kannur, Kerala, India.; Reader, Department of Oral and
Maxillofacial Surgery, SMBT Dental College, Sangamner Taluka, Maharashtra, India.
PY - 2013
SN - 1526-3711 (Electronic)
SP - 1080-6
T2 - The journal of contemporary dental practice
VL - 14
Y2 - 11 y3 - 1
ID - 14478
ER -
TY - JOUR
AN - rayyan-563561918
AU - Ahamed, S.
AU - Jalaluddin, M.
AU - Khalid, I.
AU - Moon, N.
AU - Shafi, T. K.
AU - Ali, F. M.
DO - 10.5005/jp-journals-10024-1455
IS - 6
PY - 2013
SP - 1080-1086
periodontitis: Clinical and microbiological results
T2 - Journal of Contemporary Dental Practice
periodontitis: Clinical and microbiological results
84903168825&doi=10.5005%2fjp-journals-10024-
1455&partnerID=40&md5=53cec312054099fa9c02ece6fd4ebf97
VL - 14
ID - 15292
ER -
TY - JOUR
AB - Naturally competent bacteria acquire DNA from their surroundings to survive
in nutrient-poor environments and incorporate DNA into their genomes as new genes
for improved survival. The secretin HofQ from the oral pathogen Aggregatibacter
actinomycetemcomitans has been associated with DNA uptake. Cytokine sequestering is
a potential virulence mechanism in various bacteria and may modulate both host
defense and bacterial physiology. The objective of this study was to elucidate a
possible connection between natural competence and cytokine uptake in A.
actinomycetemcomitans. The extramembranous domain of HofQ (emHofQ) was shown to
interact with various cytokines, of which IL-8 exhibited the strongest interaction.
The dissociation constant between emHofQ and IL-8 was 43 nM in static settings and
2.4 μM in dynamic settings. The moderate binding affinity is consistent with the
hypothesis that emHofQ recognizes cytokines before transporting them into the
cells. The interaction site was identified via crosslinking and mutational
analysis. By structural comparison, relateda type I KH domain with a similar
interaction site was detected in the Neisseria meningitidis secretin PilQ, which
has been shown to participate in IL-8 uptake. Deletion of hofQ from the A.
actinomycetemcomitans genome decreased the overall biofilm formation of this
organism, abolished the response to cytokines, i.e., decreased eDNA levels in the
presence of cytokines, and increased the susceptibility of the biofilm to tested β-
lactams. Moreover, we showed that recombinant IL-8 interacted with DNA. These
results can be used in further studies on the specific role of cytokine uptake in
bacterial virulence without interfering with natural-competence-related DNA uptake.
AN - rayyan-563560275
AU - Ahlstrand, T.
AU - Torittu, A.
AU - Elovaara, H.
AU - Välimaa, H.
AU - Pöllänen, M. T.
AU - Kasvandik, S.
AU - Högbom, M.
AU - Ihalin, R.
DO - 10.1080/21505594.2018.1499378
IS - 1
KW - amoxicillin plus clavulanic acid
ampicillin
cytokine
doxycycline
interleukin 1beta
interleukin 6
interleukin 8
leukotoxin
tetracycline
amino terminal sequence
article
bacterial phenomena and functions
bacterial virulence
binding affinity
biofilm
chemical phenomena
cloning
comparative study
controlled study
dissociation constant
DNA cross linking
dynamics
enzyme binding
Escherichia coli
fluorescence
gel mobility shift assay
gene cluster
host pathogen interaction
human
human cell
immunocompetence
immunogenicity
incubation temperature
infection sensitivity
liquid chromatography
mass spectrometry
melting temperature
Neisseria meningitidis
nonhuman
periodontitis
plasmid
polymerase chain reaction
protein expression
quantitative analysis
sequence homology
steady state
structural gene
surface plasmon resonance
LA - English
PY - 2018
SN - ["2150-5608", "2150-5594"]
SP - 1205-1223
ST - Interactions between the aggregatibacter actinomycetemcomitans secretin HofQ
and host cytokines indicate a link between natural competence and interleukin-8
uptake
T2 - Virulence
TI - Interactions between the aggregatibacter actinomycetemcomitans secretin HofQ
and host cytokines indicate a link between natural competence and interleukin-8
uptake
VL - 9
ID - 13649
ER -
TY - JOUR
AB - Background: chronic Periodontitis is considered to be an inflammatory disease
and is characterized by the damaging the connective tissue and supporting bone due
to secondary infection by periodontal bacteria. Chlorhexidine has been used in the
dental practice as an excellent antiplaque agent. Chlorhexidine not only exhibits
special property of substantivity, it also possesses a broad antimicrobial spectrum
which makes its use in wide variety of oral disorders. Virtually all disciplines of
dentistry make use of this material in different formulations like mouth wash, gel,
spray, varnish, and restorative material. Aims of study: The aim of this study was
to evaluate the clinical effectiveness of locally delivered Chlorhexidine gel as an
adjunctive therapy to scaling and root planing in treatment of chronic
periodontitis. Material and methods: five patients with chronic periodontitis were
selected. Pocket depth between 4 and 6 mm was selected and the patient had two
sites on his mouth (splitting mouth). A total of 17 control sites were scaled and
root planed and 17 test sites were scaled and root planed and Chlorhexidine gel was
added. The clinical parameters, probing depth (PD), clinical attachment level
(CAL), plaque index (PI) and bleeding on probing (BOP), gingival index were
recorded at baseline, 1 week, 2 weeks and 4 weeks. Results: From baseline to a
period of 4 weeks, significant difference was found between test and control group
for PD, CAL, PI and BOP. Conclusions: Subgingival injection of Chlorhexidine gel
adjunct with scaling and root planing appeared to cause significant improvement
compared with scaling and root planing alone in persons with chronic periodontitis.
AN - rayyan-563560142
AU - Ahmad, B. Z.
DO - 10.37506/v14/i1/2020/ijfmt/192957
IS - 1
KW - chlorhexidine
periokin
article
bleeding on probing
clinical article
clinical attachment level
controlled study
dental parameters
drug efficacy
gingival index
human
plaque index
probing depth
LA - English
PY - 2020
SN - ["0973-9130", "0973-9122"]
SP - 544-550
ST - The efficacy of chlorhexidine gel as an adjunctive treatment for patient with
T2 - Indian J. Forensic Med. Toxicol.
TI - The efficacy of chlorhexidine gel as an adjunctive treatment for patient with
VL - 14
ID - 13516
ER -
TY - JOUR
AB - Objective: To prepare a novel nanoemulsion- Carbopol® 934 gel for Eugenol, in
order to prevent the periodontitis. Material and methods: Spontaneous
emulsification method was used for the preparation of nanoemulsion in which it
contain Eugenol (oil phase), Tween-80 (surfactant), and PEG (co-surfactant). To the
development of best nanoemulsion, three-factor three-level central composite design
was used in which %oil; %Smix and % water were optimized as independent variables.
An optimized–nanoemulsion were converted to nanoemulsion–Carbopol® 934 gel.
Results: 5.5% oil, 35.5% Smix and 59.0% water were optimized as independent and
dependent variables. Finally dependent variables optimized as a particle size (nm),
PDI and %transmittance were observed 79.92 ± 6.33 nm, 0.229 ± 0.019, and 98.88 ±
1.31% respectively. The values of final results for dependent variables like
particle size (nm), PDI and % transmittance were evaluated as 79.92 ± 6.33 nm,
0.229 ± 0.019, and 98.88 ± 1.31%, respectively. TEM and SEM showed a spherical
shape of developed nanoemulsion with refractive index (1.63 ± 0.038), zeta
potential (−19.16 ± 0.11), pH (7.4 ± 0.06), viscosity (34.28 ± 6 cp), and drug
content of 98.8 ± 0.09%. After that a final optimized EUG–NE–Gel was assessed on
the basis of their pH measurement, drug content, syringeability, and mucoadhesion
on the goat buccal mucosa. Optimized EUG-NE-Gel (Tween-80 and Carbopol® 934 used)
showed the results, to improve the periodontal drug delivery of EUG in future.
Conclusion: EUG-NE-Gel showed a significant role in anti-inflammatory activity,
analgesic, and anesthetic, antibacterial, and treatment of periodontal disease.
AN - rayyan-563560175
AU - Ahmad, N.
AU - Ahmad, F. J.
AU - Bedi, S.
AU - Sharma, S.
AU - Umar, S.
AU - Ansari, M. A.
DO - 10.1016/j.jsps.2019.04.014
IS - 6
KW - carbomer
doxycycline
eugenol
interleukin 1beta
polysorbate 80
alveolar bone loss
animal experiment
animal model
animal tissue
article
comparative study
controlled study
cooling
drug formulation
experimental periodontitis
freeze thawing
gingival index
gingival tissue
gingivitis
growth inhibition
heating
hydrodynamics
in vitro study
inflammation
male
microemulsion
molecular weight
mucoadhesion
nanoemulsion
nonhuman
particle size
periodontal disease
pH
pH measurement
phase separation
rat
reduction (chemistry)
refraction index
scanning electron microscopy
thermodynamics
transmission electron microscopy
viscosity
zeta potential
LA - English
PY - 2019
SN - 1319-0164
SP - 778-790
ST - A novel Nanoformulation Development of Eugenol and their treatment in
inflammation and periodontitis
T2 - Saudi Pharm. J.
TI - A novel Nanoformulation Development of Eugenol and their treatment in
inflammation and periodontitis
VL - 27
ID - 13549
ER -
TY - JOUR
AB - Targeted therapy as well as reduced adverse effects are the advantages of
local drug delivery in dental caries. The application of nanotechnology in this
context has gained increasing momentum during last years. A literature search here
has provided a brief overview to present the recent developments in using
nanoparticles for local treatment of dental caries. Nanoparticles as delivery
systems, can entrap substances/drugs and use the advantages of small size and
better penetration. They can also profit from biomimetic approaches to provide more
effective treatment. Thoroughly, nanotechnology-based treatment of dental caries in
situ, may introduce a novel aid in the field of dentistry.
AN - rayyan-563560228
AU - Ahmadian, E.
AU - Shahi, S.
AU - Yazdani, J.
AU - Maleki Dizaj, S.
AU - Sharifi, S.
DO - 10.1016/j.biopha.2018.09.026
KW - alendronic acid
amelogenin
biomimetic material
calcium phosphate
nanocarrier
nanomaterial
nanoparticle
poloxamer
silver nanoparticle
triclosan
biomimetics
cytotoxicity
dental caries
drug efficacy
enamel
human
hydrogel
local therapy
micelle
nanomedicine
nanotechnology
particle size
physical chemistry
priority journal
review
tooth plaque
LA - English
PY - 2018
SN - ["1950-6007", "0753-3322"]
SP - 443-447
ST - Local treatment of the dental caries using nanomaterials
T2 - Biomed. Pharmacother.
TI - Local treatment of the dental caries using nanomaterials
VL - 108
ID - 13602
ER -
TY - JOUR
AB - Objectives. Periodontitis is characterized by inflammatory destruction of
periodontal tissue, loss of attachment, and bone resorption. The increase in
reactive oxygen species (ROS) is responsible for the oxidative damage occurring in
periodontal tissues. Melatonin has important immunomodulatory, anti-inflammatory,
and powerful antioxidant functions. The current study was carried out to evaluate
the effect of topical melatonin gel as an adjunct to nonsurgical periodontal
therapy. Methods. This split-mouth randomized controlled clinical trial was
performed on 24 patients with grade II periodontitis. Two sites in each patient
were randomly assigned; test sites were treated by nonsurgical therapy followed by
intrapocket application of 5% melatonin gel. Control sites were treated by
nonsurgical therapy followed by intrapocket application of placebo gel. Both the
melatonin and placebo gel were applied weekly once for four weeks. Assessment of
clinical parameters (PD and CAL) was done at baseline and 3 months after therapy.
Total antioxidative capacity (TAC) and matrix metalloproteinase-9 (MMP-9) levels in
GCF were also evaluated utilizing commercially available enzyme-linked
immunosorbent assay kits (ELISA) at baseline and 3 months after therapy. Results.
Treatment with topical melatonin was associated with a reduction in periodontal
inflammation reflected as an improvement in the clinical periodontal parameters.
Melatonin-treated sites showed a more statistically significant percent reduction
in PD and more statistically significant percent gain in CAL than the control site.
Additionally, a significant increase in TAC and a significant decrease in MMP-9
levels in GCF were found in melatonin-treated sites in comparison to control sites.
Conclusions. The adjunctive use of topical melatonin gel with nonsurgical
periodontal therapy has potent anti-inflammatory and antioxidant activity in the
treatment of grade II periodontitis patients.
AN - rayyan-563560038
AU - Ahmed, E.
AU - Shaker, O. G.
AU - Yussif, N.
AU - Ghalwash, D. M.
DO - 10.1155/2021/8840167
KW - container
dental curette
ELISA kit
ELISA reader
Gracey Curettes
periodontal probe
scaler
X ray film
gel
gelatinase B
melatonin
placebo
adjuvant therapy
adult
article
clinical article
conservative treatment
controlled study
female
gingival index
gingivitis
human
local therapy
male
multicenter study
periodontal disease assessment
plaque index
probing depth
topical treatment
treatment duration
LA - English
PY - 2021
SN - ["1687-8736", "1687-8728"]
ST - Effect of Locally Delivered Melatonin as an Adjunct to Nonsurgical Therapy on
GCF Antioxidant Capacity and MMP-9 in Stage II Periodontitis Patients: A Randomized
T2 - Int. J. Dent.
TI - Effect of Locally Delivered Melatonin as an Adjunct to Nonsurgical Therapy on
GCF Antioxidant Capacity and MMP-9 in Stage II Periodontitis Patients: A Randomized
VL - 2021
ID - 13412
ER -
TY - JOUR
AB - Background: Data concerning treatment outcomes in patients with generalized
aggressive periodontitis (GAgP) are limited. The aim of this study is to
investigate 6-month clinical and microbiologic outcomes of the one-stage full-mouth
disinfection (OSFMD) in the management of patients with GAgP. Methods: Twenty-seven
patients with advanced GAgP were included in this prospective follow-up
intervention study. Clinical and microbiologic parameters were collected at
baseline and 3 and 6 months after the OSFMD. Patient-, tooth-, and site-level
analyses were carried out. Subgingival samples from moderate (4 to 5 mm) and deep
(≥6 mm) pocket sites were analyzed using a polymerase chain reaction for
Aggregatibacter actinomycetemcomitans (previously Actinobacillus
actinomycetemcomitans), Prevotella intermedia, Porphyromonas gingivalis, Tannerella
forsythia (previously T. forsythensis), and Treponema denticola. Results: The OSFMD
resulted in significant improvements in all parameters. After 6 months, the whole-
mouth probing depth (PD) decreased from 4.2 ±1.1 mm to 2.8 ± 0.6 mm, and the
clinical attachment level was reduced from 4.5 ±1.2 mm to 3.4 ±1.1 mm (P<0.001).
When data were analyzed based on the frequency distribution of PD, the number of
sites with PD ≥5 mm decreased by 61% from baseline values, and mean PD reductions
of 1.5 and 2.5 mm were noted in moderate and deep pockets, respectively. At 6
months, percentages of moderate and deep sites free of pathogens were 40% and 27%,
respectively. Conclusion: The OSFMD may be a viable approach to deal with severe
GAgP.
AN - rayyan-563560589
AU - Aimetti, M.
AU - Romano, F.
AU - Guzzi, N.
AU - Carnevale, G.
DO - 10.1902/jop.2010.100468
IS - 6
KW - bacterial DNA
chlorhexidine
adult
aggressive periodontitis
anaerobic bacterium
article
bacterial load
chi square distribution
clinical trial
female
gel
human
isolation and purification
lavage
male
methodology
microbiology
mouth hygiene
nonparametric test
patient care
periodontics
prospective study
recurrent disease
LA - English
PY - 2011
SN - 0022-3492
SP - 845-853
ST - One-stage full-mouth disinfection as a therapeutic approach for generalized
TI - One-stage full-mouth disinfection as a therapeutic approach for generalized
VL - 82
ID - 13963
ER -
TY - JOUR
AN - rayyan-563561148
AU - Ainamo, J.
AU - Lie, T.
AU - Ellingsen, B. H.
AU - Hansen, B. F.
AU - Johansson, L. A.
AU - Karring, T.
AU - Kisch, J.
AU - Paunio, K.
AU - Stoltze, K.
IS - 9
KW - metronidazole
adult
aged
bleeding
conference paper
female
human
male
periodontitis
LA - English
PY - 1992
SN - 0303-6979
SP - 723-729
ST - Clinical responses to subgingival application of a metronidazole 25% gel
compared to the effect of subgingival scaling in adult periodontitis
T2 - J. CLIN. PERIODONTOL.
TI - Clinical responses to subgingival application of a metronidazole 25% gel
VL - 19
ID - 14522
ER -
TY - JOUR
AB - A newly developed metronidazole 25% dental gel was compared with subgingival
scaling in the treatment of adult periodontitis. 206 patients in 9 centres
participated in the study. Probing pocket depth (PPD) and bleeding on probing (BOP)
were recorded before treatment and 2, 6, 12, 18, and 24 weeks after the treatment.
All patients had at least 1 tooth in each quadrant with a PPD of 5 mm or more. The
treatments consisted of 2 applications of dental gel (days 0 and 7) in 2 randomly
selected quadrants (split mouth design) and 2 sessions of subgingival scaling (1
quadrant on day 0, and 1 quadrant on day 7). Instruction in oral hygiene was given
2 weeks after completed treatment. The average PPD and the average frequency of BOP
were calculated over all sites with initial PPD of 5 mm or more. PPD and BOP were
thus, at each examination, calculated from the same sites. The mean PPD was 5.9 mm
before gel application and 5.8 mm before scaling (p = 0. 3 1). BOP was 88% in both
treatment groups. 24 weeks after the treatment, PPD and BOP were significantly
reduced in both groups and for both parameters (p < 0.0 1). PPD was reduced by 1. 3
mm after gel application and 1.5 mm after scaling; BOP was reduced by 32% and 39%,
respectively. The difference between the treatments was statistically significant,
but considered as clinically unimportant.
AN - rayyan-563562291
AU - Ainamo, J.
AU - Lie, T.
AU - Hansen, B. F.
AU - Johansson, L. A.
AU - Karring, T.
AU - Kisch, J.
AU - Paunio, K.
AU - Stoltze, K.
DO - 10.1111/j.1600-051X.1992.tb02535.x
IS - 9
PY - 1992
SN - 0303-6979
SP - 723-729
ST - CLINICAL-RESPONSES TO SUBGINGIVAL APPLICATION OF A METRONIDAZOLE 25-PERCENT
GEL COMPARED TO THE EFFECT OF SUBGINGIVAL SCALING IN ADULT PERIODONTITIS
T2 - JOURNAL OF CLINICAL PERIODONTOLOGY
TI - CLINICAL-RESPONSES TO SUBGINGIVAL APPLICATION OF A METRONIDAZOLE 25-PERCENT
GEL COMPARED TO THE EFFECT OF SUBGINGIVAL SCALING IN ADULT PERIODONTITIS
VL - 19
Y2 - 10
ID - 15665
ER -
TY - JOUR
AN - rayyan-563562115
AU - Ainamo, J.
AU - Lie, T.
AU - Hansen, B. F.
AU - Johansson, L. ‐Å
AU - Karring, T.
AU - Kisch, J.
AU - Paunio, K.
AU - Stoltze, K.
DO - 10.1111/j.1600-051X.1992.tb02535.x
IS - 9
PY - 1992
SP - 723-729
ST - Clinical responses to subgingival application of a metronidazole 25% gel
T2 - Journal of Clinical Periodontology
TI - Clinical responses to subgingival application of a metronidazole 25% gel
0026673649&doi=10.1111%2fj.1600-
051X.1992.tb02535.x&partnerID=40&md5=830e4f717769cb079c0ad2d8e4a12a26
VL - 19
ID - 15489
ER -
TY - JOUR
AB - This study was aimed at formulating a bioabsorbable, controlled-release,
nanoemulgel of Quercetin, a potent antimicrobial and anti-inflammatory agent for
the treatment of periodontitis that could improve its solubility and
bioavailability. Screening of components was carried out based on the solubility
studies. Nanoemulsion containing cinnamon oil as the oil phase, tween 80 and
Carbitol® as the surfactant-cosurfactant mixture (Smix) and water as the aqueous
phase containing 125 µg/200 µL of Quercetin was prepared by using spontaneous
emulsification method. Nanoemulgel was prepared using 23% w/v poloxamer 407 as gel
base. Comprehensive evaluation of the formulated nanoemulgel was carried out, and
the optimized formulation was studied for drug release using Franz vertical
diffusion cells. The formulated nanoemulgelexhibited a remarkable release of 92.4%
of Quercetin at the end of 6 h, as compared to that of pure Quercetin-loaded gel
(<3% release). The viscosity of the prepared nanoemulgel was found to be 30,647 ±
0.32 cPs at 37 °C. Also, molecular dynamics (MD) simulation was utilized to
understand the gelation process and role of each component in the formulation. The
present study revealed that the developed nanoemulgel of Quercetin could be a
potential delivery system for clinical testing in periodontitis.
AN - rayyan-563560252
AU - Aithal, G. C.
AU - Nayak, U. Y.
AU - Mehta, C.
AU - Narayan, R.
AU - Gopalkrishna, P.
AU - Pandiyan, S.
AU - Garg, S.
DO - 10.3390/molecules23061363
IS - 6
KW - nanomaterial
quercetin
computer simulation
diffusion
drug stability
gel
molecular dynamics
periodontitis
thermodynamics
LA - English
PY - 2018
SN - 1420-3049
ST - Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for
Periodontitis: Development and Computational Simulations
T2 - Molecules
TI - Localized In Situ Nanoemulgel Drug Delivery System of Quercetin for
Periodontitis: Development and Computational Simulations
VL - 23
ID - 13626
ER -
TY - JOUR
AB - Background: In order to prevent permanent damage to the tooth-supporting
structures from gingival inflammation, new, improved approaches to oral biofilm
removal and control are needed. Existing methodologies for evaluating efficacy are
laborious and subjective. Goal of this pilot study was to determine whether Optical
Coherence Tomography (OCT) imaging can be used as a convenient alternative to
clinical indices to track the reponse of inflamed gingiva to a novel toothpaste.
Study: 10 subjects with gingivitis were recruited. 5 subjects received a novel
dentifrice, Livionex Dental Gel, and the other 5 received Colgate Total toothpaste.
In this randomized, controlled, double-blind pilot study (UCI IRB 2002-2805),
plaque, gingival, periodontal indices, and full pocket charting were documented by
a clinician. After OCT and intra-oral images, volunteers received standardized oral
hygiene instructions. Patient oral hygiene and indices listed above were documented
at weekly intervals for 6 weeks. Periodontal index was determined at beginning and
end of the study. From OCT images, changes in soft and hard supporting tissues of
the teeth were measured using a software-based pointto- point measurement
capability. The changes in gingival health over time based on clinical measurements
were used as the standard for evaluating images of the gingiva. Results: A
reduction of 10-30% in gingival soft tissue swelling was apparent in OCT images
after 1 week, and continued progressively to end of the study; rate and amount of
change varied considerably between subjects and dentifrice used. Pocket depths as
measured from the OCT images also reduced progressively, and soft tissue pocket
width decreased also. Plaque and gingival index were the earliest clinical
indicators of changes in gingival inflammation. Conclusion: Improved gingival
health resulting from better oral hygiene can be mapped efficiently using OCT.
AN - rayyan-563560494
AU - Ajdaharian, J.
AU - Dadkhah, M.
AU - Sarraf, A.
AU - Kohanchi, D.
AU - Chan, G.
AU - Jow, B.
AU - Eun Chung, N.
AU - Wink, C.
AU - Wilder-Smith, P.
DO - 10.1002/lsm.22127
KW - toothpaste
sodium fluoride plus triclosan
gingivitis
society
laser
surgery
imaging
mouth hygiene
periodontics
soft tissue
pilot study
tooth
health
gingiva
human
patient
methodology
volunteer
biofilm
tissues
clinical indicator
edema
software
optical coherence tomography
LA - English
PY - 2013
SN - 0196-8092
SP - 37
ST - Imaging gingivitis response to a novel dentifrice
T2 - Lasers Surg. Med.
TI - Imaging gingivitis response to a novel dentifrice
VL - 45
ID - 13868
ER -
TY - JOUR
AB - In this study, the clinical efficacies of systemic doxycycline (SD) and local
doxycycline (LD) in the treatment of chronic periodontitis were compared. Forty-
five patients were studied in 3 main groups with 5 treatments: SD alone,
SD+scaling-root planing (SD+SRP), LD alone, LD+SRP and SRP alone. Antibiotic-
treated patients were given doxycycline treatment alone in 1 quadrant of their
upper jaws, and doxycycline+SRP was given in the contralateral quadrant. The areas
included at least 4 teeth with > or = 5 mm pockets. Probing depth (PD), clinical
attachment level, gingival index, sulcular bleeding index and plaque index values
were recorded at baseline and the 7th week. The results were statistically
analyzed. All of the clinical parameters were significantly reduced by all
treatments (P < or = 0.05). The SD and LD treatments alone provided significant
clinical healings. The significant differences among the groups were only in PD at
the 7th week. The LD treatment provided significantly higher PD reduction than the
SD treatment (P < or = 0.05). No significant difference was found between the
SD+SRP and the LD+SRP treatments. There was no significant difference between
SD+SRP and SRP alone treatment (P > 0.05). The SD group showed lower PD reduction
than SRP group (P < or = 0.05), while no significant difference was found between
LD and SRP treatments. The LD alone treatment seemed more effective than SD alone
treatment on PD reduction, but no significant difference was found between them
when combined with the SRP. LD may be more preferable than SD as an adjunct to
mechanical treatment since LD seems more effective than SD on PD reduction and does
not have the side effects of SD.
AN - rayyan-563560870
AU - Akalin, F. A.
AU - Baltacioglu, E.
AU - Sengün, D.
AU - Hekimoglu, S.
AU - Taşkin, M.
AU - Etikan, I.
AU - Fişenk, I.
DO - 10.2334/josnusd.46.25
IS - 1
doxycycline
adult
article
chronic disease
clinical trial
comparative study
controlled study
drug effect
female
follow up
gel
human
male
middle aged
periodontal disease
periodontics
periodontitis
tooth plaque
wound healing
LA - English
PY - 2004
SN - 1343-4934
SP - 25-35
ST - A comparative evaluation of the clinical effects of systemic and local
doxycycline in the treatment of chronic periodontitis
T2 - J Oral Sci
TI - A comparative evaluation of the clinical effects of systemic and local
doxycycline in the treatment of chronic periodontitis
VL - 46
ID - 14244
ER -
TY - JOUR
AB - Local administration of antibiotics in periodontal therapy can be provided
with an appropriate delivery system. The purpose of this study was to evaluate the
clinical effectiveness of chitosan, both as a carrier in gel form and as an active
agent in the treatment of chronic periodontitis (CP). The chitosan gel (1% w/w)
incorporated with or without 15% metronidazole was prepared and applied adjunctive
to scaling and root planing (SRP) in comparison to SRP aione (control group-C), in
CP patients. The clinical parameters such as probing depth (PD), clinical
attachment level, the amount of gingival recession, plaque index, gingival index,
and gingival bleeding time index were recorded at baseline and at weeks 6, 12, and
24. In all groups, significant improvements were observed in clinical parameters
between baseline and week 24 (p < 0.05). The reductions in PD values were 1.21 mm
for Ch, 1.48 mm for Ch + M, and 0.94 mm for C groups. No complications related to
the chitosan were observed in patients throughout the study period. It is suggested
that chitosan itself is effective as well as its combination with metronidazole in
CP treatment due to its antimicrobial properties. © 2006 Wiley Periodicals, Inc.
AN - rayyan-563560753
AU - Akincibay, H.
AU - Şenel, S.
AU - Ay, Z. Y.
DO - 10.1002/jbm.b.30596
IS - 2
KW - chitosan
metronidazole
adult
antibiotic therapy
article
chronic disease
clinical article
controlled study
drug efficacy
female
gel
gingiva
gingiva bleeding
human
male
periodontitis
tooth plaque
treatment outcome
LA - English
PY - 2007
SN - ["1552-4973", "1552-4981"]
SP - 290-296
ST - Application of chitosan gel in the treatment of chronic periodontitis
T2 - J. Biomed. Mater. Res. Part B Appl. Biomater.
TI - Application of chitosan gel in the treatment of chronic periodontitis
VL - 80
ID - 14127
ER -
TY - JOUR
agent in the treatment of chronic periodontitis (CP). The chitosan gel (1 % w/w)
incorporated with or without 15 % metronidazole was prepared and applied adjunctive
to scaling and root planing (SRP) in comparison to SRP alone (control group-C), in
CP treatment due to its antimicrobial properties. (c) 2006 Wiley Periodicals, Inc.
AN - rayyan-563562051
AU - Akincibay, H.
AU - Senel, S.
AU - Ay, Z. Y.
DO - 10.1002/jbm.b.30596
IS - 2
PY - 2007
SN - ["1552-4973", "1552-4981"]
SP - 290-296
T2 - JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
VL - 80
Y2 - 2
ID - 15425
ER -
TY - JOUR
AN - rayyan-563562079
AU - Akincibay, H.
AU - Şenel, S.
AU - Ay, Z. Y.
DO - 10.1002/jbm.b.30596
IS - 2
PY - 2007
SP - 290-296
T2 - Journal of Biomedical Materials Research - Part B Applied Biomaterials
33847004041&doi=10.1002%2fjbm.b.30596&partnerID=40&md5=dbbe3a537f2df8d3281b5736e1b1
a385
VL - 80
ID - 15453
ER -
TY - JOUR
agent in the treatment of chronic periodontitis (CP). The chitosan gel (1% w/w)
incorporated with or without 15% metronidazole was prepared and applied adjunctive
to scaling and root planing (SRP) in comparison to SRP alone (control group-C), in
CP treatment due to its antimicrobial properties.
AN - rayyan-563561324
AU - Akncbay, H.
AU - Senel, S.
AU - Ay, Z. Y.
DO - 10.1002/jbm.b.30596
IS - 2
J2 - J Biomed Mater Res B Appl Biomater
KW - Adult
Anti-Infective Agents, Local/administration & dosage
Biocompatible Materials/administration & dosage
Chitosan/*administration & dosage
Chronic Disease
Dental Materials
Drug Carriers
Female
Gels
Humans
Male
Materials Testing
Metronidazole/administration & dosage
Middle Aged
Periodontitis/*drug therapy/pathology/therapy
LA - eng
N1 - Department of Periodontology, Hacettepe University, 06100 Ankara, Turkey.
PY - 2007
SN - 1552-4973 (Print)
SP - 290-6
T2 - Journal of biomedical materials research. Part B, Applied biomaterials
VL - 80
Y2 - 2
ID - 14698
ER -
TY - JOUR
AB - Introduction: On the topic of adjuncts to scaling and root planing (SRP),
numerous randomized clinical trials (RCTs) were published by a single group of
authors and frequently reported unusually large effect sizes. A meta-analysis in
part 1 of this project failed to explain the causes for these unusual findings. We
assessed the reporting quality and trial registration discrepancies to examine the
possibility of replicating the work of this research group as well as the overall
rigor of the research methodology. Methods: This study was preregistered at the
Open Science Framework (https://osf.io/4meyd/). The Scopus platform was utilized
for the RCT search on SRP adjuncts in intrabony defects in patients with
periodontitis as compared with SRP alone. The search analysis was limited from 2010
to 2017, and RCTs on SRP adjuncts published by a single research group were
selected for screening and inclusion. RCT registration records were assessed for
consistency. Results: Out of 92 studies that were retrieved from Scopus and PubMed,
32 were included for quality assessment per the CONSORT guidelines (Consolidated
Standards of Reporting Trials). Results showed that all RCTs were characterized by
a low reporting quality. The majority of CONSORT items scored <50%, including
critical items (randomization, registration, and blinding). When registration
records were compared with published RCTs, several discrepancies were found. The
per-protocol follow-up duration was compared against the study's initiation and
termination dates. Only 38% of the RCTs presented a follow-up period within the
initiation and termination dates. The remaining RCTs showed inconsistent follow-up
in comparison with the initiation and termination dates. Conclusion: RCTs by this
group were characterized by poor adherence to reporting quality guidelines. Crucial
RCT elements, such as randomization, blinding, and primary outcomes, were not
reported properly. RCT registration records revealed systematic inconsistencies
when compared with RCT publication. Therefore, the unusually large effects reported
by this group should be viewed with extreme caution. Knowledge Transfer Statement:
The included randomized clinical trials were characterized by poor adherence to
reporting quality guidelines, missing information about important trial items, and
discrepancies between the reports and trial registrations. This quality assessment
should guide clinical research and show clinicians that they should be cautious
when applying evidence in their clinical practice.
AN - rayyan-563562566
AU - Al-Abedalla, K.
AU - Gunsolley, J. C.
AU - Shaqman, M.
AU - Ioannidou, E.
DO - 10.1177/23800844211034831
IS - 3
PY - 2022
SN - ["2380-0844", "2380-0852"]
SP - 242-255
ST - Unusual Findings in Trials Evaluating Adjuncts to Scaling and Root Planing:
Reporting Quality (Part 2)
T2 - JDR CLINICAL & TRANSLATIONAL RESEARCH
TI - Unusual Findings in Trials Evaluating Adjuncts to Scaling and Root Planing:
Reporting Quality (Part 2)
VL - 7
Y2 - 7
ID - 15940
ER -
TY - JOUR
AN - rayyan-563561659
AU - Al-Bayaty, F. H.
AU - Abdullah, N. A. B.
AU - Meera, S. B. M.
AU - Zain, Z. B. M.
IS - 3
PY - 2020
SP - 928-934
ST - Formulation and evaluation of new periodontal gel from pimpinella anisum L
anise seed
T2 - Journal of International Dental and Medical Research
TI - Formulation and evaluation of new periodontal gel from pimpinella anisum L
anise seed
85092101814&partnerID=40&md5=9783049b9a934bfda0e6f050223b2b09
VL - 13
ID - 15033
ER -
TY - JOUR
AN - rayyan-563561564
AU - Al-Bayaty, F. H.
AU - Razak, M. A. A.
AU - Hussain, S. F.
AU - Mulok, T. Z.
AU - Almas, K.
AU - Smith, S.
AU - Abdulla, M. A.
IS - 2
PY - 2022
SP - 498-504
ST - Antibacterial Activity of Salvadora Persica and Benzylisothiocyanate against
Prevotella Intermedia and Eikenella Corrodens Incorporated into Periodontal Chips
TI - Antibacterial Activity of Salvadora Persica and Benzylisothiocyanate against
Prevotella Intermedia and Eikenella Corrodens Incorporated into Periodontal Chips
85133795090&partnerID=40&md5=bdcb1ef20f8688c4f13fbe410a15a109
VL - 15
ID - 14938
ER -
TY - JOUR
AB - Aim: The aim of this study was to compare the clinical effectiveness of
ozonated gel (OZ) or Chlorhexidine Gel (CHX) on patients affected with plaque-
induced gingivitis (PIG) based on the evaluation of the interleukin-1β (IL-1 β)
cytokine level as a biomarker in Gingival Crevicular Fluid (GCF) after one week of
treatment. Materials and methods: Fifty male patients affected with (PIG)
(25/group) with an average age of (18-30) years were enrolled throughout the study.
They were divided into two groups, (G1) scaling and treated with (OZ) gel and (G2)
scaling and treated with (CHX) Gel. Participants were trained to rubbing their
gingiva two times a day for 7 days. GCF were collected from four anterior teeth by
paper strips (PS) at 0-time and at 7-days after treatments. Cytokine concentrations
of IL-1β were determined in the GCF samples using Commercial ELISA diagnostic Kit
Salivary (SALIMETRICS, USA. Assay). Results: The median values of the GCF volumes
at 0-time showed that there were no statistically significant differences among the
two groups. However, at 7-days post treatments there were statistically significant
differences with G1 group showed much more effectiveness compared to G2. The values
of IL-1β concentration in each group at 0-time revealed no statistically
significant differences. While, at 7-days the results revealed that there were
statistically significant (p0.05) differences. Conclusion: GCF volume (µl) and IL-
1β concentration (pg/ml) at 7-days post-treatment was directly correlated to the
treatment used in each group (G1 and G2). OZ gel treated group showed significantly
lower GCF volume and IL-1β concentration. This highlighted the evidence in favor of
the OZ gel in the treatment of gingivitis.
AN - rayyan-563560202
AU - Al-Chalabi, M. Z.
AU - Mohamed, A. N.
IS - 2
KW - dental diagnostic device
ELISA kit
paper strip
biological marker
chlorhexidine
cytokine
interleukin 1beta
ozone
adult
article
clinical article
clinical effectiveness
clinical trial
dental scaling
gel
gingivitis
human
male
ozonation
ozone therapy
tooth plaque
LA - English
PY - 2019
SN - 0975-1459
SP - 647-652
ST - The efficiency of ozonated gel vs chlorhexidine gel as adjunct treatment to
control plaque-induced gingivitis assessed by interleukin-1β levels in gingival
crevicular fluid (A comparative clinical trial)
T2 - J. Pharm. Sci. Res.
TI - The efficiency of ozonated gel vs chlorhexidine gel as adjunct treatment to
control plaque-induced gingivitis assessed by interleukin-1β levels in gingival
crevicular fluid (A comparative clinical trial)
VL - 11
ID - 13576
ER -
TY - JOUR
AB - This study was aimed to compare the clinical effectiveness of ozonated gel
and chlorhexidine treatments on gingival crevicular fluid (GCF) volume associated
with plaque-induced gingivitis (PIG). Fifty male patients affected with (PIG),
(25/group) with an average age of (18-30) years were enrolled throughout the study.
They were divided into two groups, (G1) scaling and treated with Chlorhexidine and
(G2) scaling and treated with Ozone gel. Patients were instructed to massage their
gingiva twice a day for 1 week with the ozonated gel). GCF was collected from four
sampling tooth sites by paper strips (PS) at zero-time and day-7. The median values
of the GCF volume (μL) at 0-time showed that there were no statistically
significant differences among the two groups. However, at day-7 post-treatments
Ozone gel group showed significantly lower GCF volume. Treatment for 7 days with
Ozone gel was much more efficient in reducing GCF volume (μl) when compared with
the Chlorhexidine group.
AN - rayyan-563560006
AU - Al-Chalabi, M. Z.
AU - Mohammed, A. N.
AU - Ahmed, B. Z.
IS - 1
KW - chlorhexidine
gel
ozonated gel
unclassified drug
adult
article
comparative effectiveness
gingivitis
human
male
mouth cavity
tooth
young adult
LA - English
PY - 2021
SN - ["0976-1772", "0972-5075"]
SP - 1649-1653
ST - Comparison of Ozonated GeL and Chlorhexidine Treatments on Gingival
Crevicular Fluid Volume Associated with Plaque-Induced Gingivitis
T2 - Biochem. Cell. Arch.
TI - Comparison of Ozonated GeL and Chlorhexidine Treatments on Gingival
Crevicular Fluid Volume Associated with Plaque-Induced Gingivitis
VL - 21
ID - 13380
ER -
TY - JOUR
AB - Introduction: Fusobacterium nucleatum represents one of the predominant
anaerobic species in the oral microbiota. Penicillin-resistant F. nucleatum have
been isolated from intra- and extraoral infections. This study aimed to assess
ampicillin resistance in F. nucleatum by investigating the synthesis of resistance-
associated proteins. Methods: Ampicillin-resistant and ampicillin-susceptible F.
nucleatum isolates were obtained from 22 dental plaque samples. Two-dimensional gel
electrophoresis and mass spectrometry were used to investigate bacterial protein
synthesis. Proteins exhibiting statistically significant quantitative changes
between sensitive and resistant isolates were identified using peptide mass mapping
and matrix-assisted laser desorption/ionization time of flight/time of flight
(MALDI-TOF/TOF) mass spectrometry. Results: Twenty-three F. nucleatum isolates were
recovered from plaque samples and their ampicillin minimum inhibitory
concentrations ranged between 0.125 mu g/ml and 256 mu g/ml. Analysis of the
bacterial cellular proteins by two-dimensional gel electrophoresis resolved 154-246
distinct protein spots (mean 212, n = 9). Between 32% and 83% of the protein spots
were common for the F. nucleatum isolates. Comparisons of the protein profiles of
sensitive and resistant isolates revealed the presence of a 29 kDa protein and
significant increases in the synthesis of two proteins at 37 and 46 kDa in the
ampicillin-resistant F. nucleatum isolates. These proteins were identified as a
class D beta-lactamase, ATP-binding cassette (ABC) transporter ATP-binding protein
and enolase, respectively. Conclusion: Synthesis of a class D beta-lactamase by
ampicillin-resistant F. nucleatum isolates could complicate antimicrobial treatment
because these enzymes might confer resistance to many classes of beta-lactam
antibiotics. The differences observed in protein synthesis between ampicillin-
resistant and ampicillin-susceptible F. nucleatum may contribute to the antibiotic
resistance and virulence of these bacteria.
AN - rayyan-563562623
AU - Al-Haroni, M.
AU - Skaug, N.
AU - Bakken, V.
AU - Cash, P.
IS - 1
PY - 2008
SN - 0902-0055
SP - 36-42
ST - Proteomic analysis of ampicillin-resistant oral Fusobacterium nucleatum
TI - Proteomic analysis of ampicillin-resistant oral Fusobacterium nucleatum
VL - 23
Y2 - 2
ID - 15997
ER -
TY - JOUR
AB - AIMS: To evaluate the clinical, radiographic, immune modulatory biomarkers
and quality of life with the application of photodynamic therapy (PDT) as an
adjunctive treatment to dental scaling and root planing (SRP) in patients with
chronic periodontitis and Parkinson's disease. METHODOLOGY: Individuals who had a
confirmed diagnosis of stage III periodontitis and stage 4 Parkinson's disease
according to Hoehn and Yahr scale were involved in this study. The participants
were divided into two groups: Group SRP (n=25) received traditional dental scaling
procedure including full-mouth debridement and disinfection, and Group PDT + SRP
(n=25) received both traditional cleaning procedures along with adjunctive chloro-
aluminum phthalocyanine (CAPC) gel (0.005% concentration) mediated PDT. CAPC
photosensitizer was activated using a diode laser (wavelength=640 nm, energy=4 J,
150 mW power, and overall power density of 300 J/cm2) for 60 s. The study measured
clinical parameters such as plaque score (PI), bleeding on probing (BOP), probing
depth (PD), clinical attachment loss (CAL), and radiographic alveolar bone loss
(ABL). Proinflammatory cytokine levels such as interleukin (IL)-6 and tumor
necrosis factor alpha (TNF-α) and oral health related quality of life were also
assessed. RESULTS: The mean age of patients in Group SRP was 73.3 years, while the
mean age in Group PDT + SRP was 71.6 years. The PDT + SRP group showed a
significant reduction in all clinical parameters at 6 and 12 months compared to the
SRP group alone (p<0.05). IL-6 and TNF-α levels were significantly reduced in the
PDT + SRP group at 6 months compared to the SRP group alone (p<0.05). However, at
12 months, both groups showed comparable TNF-α levels. The results showed that
Group PDT + SRP had significantly lower OHIP scores compared to Group SRP, with a
mean difference of 4.55 (95% confidence interval [CI]: 1.98 to 7.12) (p<0.01).
CONCLUSION: Combined SRP with PDT showed significant improvement compared to SRP
alone in terms of clinical parameters, cytokine levels, and oral health-related
quality of life in individuals diagnosed with stage III periodontitis associated
with Parkinson's disease.
AN - rayyan-563559694
AU - Al-Kheraif, A. A.
AU - Javed, R.
AU - Al-Momani, M. M.
AU - Wasi, A.
AU - Mohamed, B. A.
AU - Khan, A. A.
DO - 10.1016/j.pdpdt.2023.103690
KW - aged
alveolar bone loss
article
bleeding on probing
cleaning
clinical article
controlled study
dental debridement
dental scaling
diagnosis
diode laser
disinfection
female
gene expression
health
Hoehn and Yahr scale
human
male
Parkinson disease
parkinsonism
periodontitis
quality of life
root planing
biological marker
cytokine
endogenous compound
interleukin 6
LA - English
PY - 2023
SN - 1873-1597
SP - 103690
ST - Effectiveness of photodynamic therapy on clinical and biomarker related
periodontal parameters and oral health related quality of life (OHRQoL) in
Parkinson's disease patients with stage III periodontitis
T2 - Photodiagnosis Photodyn Ther
TI - Effectiveness of photodynamic therapy on clinical and biomarker related
periodontal parameters and oral health related quality of life (OHRQoL) in
Parkinson's disease patients with stage III periodontitis
ID - 13068
ER -
TY - JOUR
AB - Aim: The aim of this study was designed to assess the peri-implant oral
hygiene parameters, clinical, radiographic, host-derived immune biomarkers and
microbiological levels after photochemotherapy (PCT) and local antibiotic therapy
(LAT) in peri-implantitis lesions among cigarette smokers. Materials and methods:
Fifty current cigarette smokers with peri-implantitis were divided into two groups:
PCT and LAT. Test implants received PCT that consisted of toluidine blue
photosensitizer and application of 660 nm diode laser with a total of 100 mW power
and 124.3 W/cm(2) energy using continuous mode of irrigation for 60 s. Control
implants received one-unit subgingival application of metronidazole gel in viscous
consistency. Clinical measurements included the assessment of plaque scores (PS),
bleeding on probing (BOP), probing depth (PD) and clinical attachment level (CAL).
Intraoral standardized digital peri-apical radiographs were taken at baseline and
at 12 months. Interleukin (IL)-( )beta and matrix metalloproteinase (MMP)-1 in the
PICF were determined using the manufacturers guide from one-step enzyme-linked
immunosorbent assay. Real-time polymerase chain reaction (PCR) for Parvimonas
micra, Porphyromonas gingivalis and Tannerella forsythia was performed and counts
evaluated at baseline, 3, 6 and 12-months. Results: Plaque scores reduced in both
groups (p < 0.05). Mean BOP percentage significantly increased in both the groups
at 1-month follow-up compared to baseline. Following this period, BOP showed
reduction from 1month to consecutive follow-up periods. The PD significantly
reduced in both the groups with no statistically significant difference when
compared between PCT and LAT groups at follow-up (p > 0.05). CAL did not change
over the period and between both groups (p > 0.05). The differences from baseline
to 12 months and between the groups for mesial and distal crestal bone levels did
not show any statistical significance (p > 0.05). The levels of IL-1 beta
significantly dropped from baseline to 12 months in the LAT group (p < 0.05).
However, for PCT groups, the levels of IL-1 beta significantly reduced only at 12-
month visit follow-up (p < 0.05). MMP-1 showed statistically significant reduction
at 9 and 12-months compared with baseline for LAT group. Both P. gingivalis and T.
forsythia showed statistically significant reduction in both the groups when values
were compared from baseline to 3-, 6- and 12-months follow-up (p < 0.05). However,
these differences were not significant when compared between the groups (p > 0.05).
Conclusion: Both PCT and LAT showed equal efficacies in improving clinical, host-
derived immune biomarkers and microbiological parameters in peri-implant infection
in cigarette smokers.
AN - rayyan-563562608
AU - Al-Khureif, A. A.
AU - Mohamed, B. A.
AU - Siddiqui, A. Z.
AU - Hashem, M.
AU - Khan, A. A.
AU - Divakar, D. D.
DO - 10.1016/j.pdpdt.2020.101684
PY - 2020
SN - ["1572-1000", "1873-1597"]
ST - Clinical, host-derived immune biomarkers and microbiological outcomes with
adjunctive photochemotherapy compared with local antimicrobial therapy in the
treatment of peri-implantitis in cigarette smokers
T2 - PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
TI - Clinical, host-derived immune biomarkers and microbiological outcomes with
adjunctive photochemotherapy compared with local antimicrobial therapy in the
treatment of peri-implantitis in cigarette smokers
VL - 30
Y2 - 6
ID - 15982
ER -
TY - JOUR
AB - The effect of topical application of a metronidazole gel (ELYZOL DENTAL GEL),
and adjunctive therapy in the treatment of adult periodontitis was assessed
clinically. A single, masked examiner performed clinical assessments. Fourteen
patients were involved, each one received four different treatments including
control, and the four treatments were randomly applied to at least one tooth in
each quadrant for each patient in a comparative split-mouth design. Clinical
examinations were carried out before treatment and 90 days after treatment. All
patients had at least one tooth in each quadrant with probing pocket depth of > or
= 5mm. The four treatment groups were: (I) One session of one hour of scaling and
root planning, (II) metronidazole 25% dental gel (ELYZOL DENTAL GEL) applied on day
0 and day 7, (III) scaling adjunctive to metronidazole 25%, and (IV) No treatment.
Instruction in oral hygiene was given to all subjects at base line examination. At
the end of the study (day 90), all groups had statistically significant improvement
in probing pocket depth (P < 0.02), and in plaque and bleeding indices (P < 0.05)
when compared to day 0. However, group III had statistically significantly greater
improvement (P < 0.03) in probing pocket depth than groups I, II and IV. Both
groups I and II had statistically significantly greater improvement (P < 0.05) in
probing pocket depth than control group. On the other hand, both groups were not
statistically significantly different from each other in probing pocket depth
improvement. It is suggested that topical Elyzol treatment may improve periodontal
health as well as subgingival scaling and root planning therapy, and adjunctive
treatment could obtain an additional therapeutic effect.
AN - rayyan-563560936
AU - Al-Mubarak, S. A.
AU - Karring, T.
AU - Ho, A.
IS - 3
KW - acylglycerol
antiinfective agent
drug derivative
Elyzol Dentalgel
metronidazole
sesame seed oil
adult
aged
article
clinical trial
comparative study
controlled study
female
follow up
gel
gingiva bleeding
human
male
middle aged
mouth hygiene
nonparametric test
periodontitis
statistics
tooth plaque
LA - English
PY - 2000
SN - 1466-2094
SP - 64-70
ST - Clinical evaluation of subgingival application of metronidazole 25%, and
adjunctive therapy
T2 - J Int Acad Periodontol
TI - Clinical evaluation of subgingival application of metronidazole 25%, and
adjunctive therapy
VL - 2
ID - 14310
ER -
TY - JOUR
AB - Objectives: The aim of this study was to identify bacteria associated with
peri-implant diseases using Denaturing Gradient Gel Electrophoresis (DGGE) as a
method for microbiological assessment. Methods: Subgingival plaque samples along
with essential patient information and clinical indices were taken from 22 subjects
showing signs of peri-implant diseases. Bacteria were detected from extracted DNA
either by species specific PCR, or by using PCR coupled with DGGE and subsequent
sequencing of resolved and excised bands. Results: Altogether, approximately 26
different species were identified as components of peri-implant plaque, including
non-culturable bacteria. Percentages of periodonto pathogenic bacterial species in
plaque samples were: 82% of shallow pocket (<3 mm), 51% of moderate pocket depth,
and 63% of deep pocket (>7.5 mm). A positive correlation was found between highly
pathogenic bacteria and both Gingival Index score and pocket depth. Conclusion:
DGGE in combination with sequence analysis is a comprehensive and sensitive
microbiological method for detection and identification of multiple bacterial
species in peri-implant disease conditions. This makes it a valuable
microbiological diagnostic method to help the clinician to conduct a more accurate
clinical diagnosis and to plan appropriate treatment for peri-implant diseases.
Based on results, Fusobacterium and Prevotella species were most prevalent in early
stages of disease whilst an increased diversity of species was present during more
advanced stages of disease. (c) 2012 Elsevier Ltd. All rights reserved.
AN - rayyan-563562633
AU - Al-Radha, A. S. D.
AU - Pal, A.
AU - Pettemerides, A. P.
AU - Jenkinson, H. F.
DO - 10.1016/j.jdent.2012.08.006
IS - 11
PY - 2012
SN - ["0300-5712", "1879-176X"]
SP - 989-998
ST - Molecular analysis of microbiota associated with peri-implant diseases
T2 - JOURNAL OF DENTISTRY
TI - Molecular analysis of microbiota associated with peri-implant diseases
VL - 40
Y2 - 11
ID - 16007
ER -
TY - JOUR
AB - OBJECTIVE: The aim of this study is to evaluate the effect of the subgingival
application of 0.8% hyaluronic acid (HA) gel (GENGIGEL®) as an adjunct to scaling
and root planing (SRP) on clinical parameters and expression of human beta
defensin-2 (hBD-2) in patients with moderate to severe chronic periodontitis.
MATERIALS AND METHODS: In this randomized, split mouth design study, 24
participants with moderate to severe chronic periodontitis were evaluated after
full mouth SRP. In the test sites 1 mL of 0.8% hyaluronan gel was applied
subgingivally after SRP at baseline and 1 week post therapy. Plaque index (PI),
gingival index (GI), papillary bleeding index (PBI), periodontal probing depth
(PPD), and clinical attachment loss (CAL) were recorded and gingival crevicular
fluid (GCF) samples were collected at baseline, after 6 and 12 weeks. Expression of
human beta defensin-2 (hBD-2) was analyzed by enzyme-linked immunosorbent assay.
RESULTS: At baseline, there were no statistical differences between test and
control sites in all clinical parameters and hBD-2 expression. An improvement of
PI, GI, PBI, PPD, and CAL was observed at 6 and 12 weeks (p < 0.05) in both groups.
Clinically, it was noticed that all indices except CAL had more statistically
significant reduction in test sites than control sites at 6 and 12 weeks. The hBD-2
levels were significantly higher in the test sites than in the control sites at 6
and 12 weeks. CONCLUSION: The local application of 0.8% hyaluronan gel with SRP
have a positive effect on periodontal health of moderate to severe chronic
periodontitis patients after 6 and 12 weeks. CLINICAL SIGNIFICANCE: Subgingival
application of 0.8% HA gel following SRP has shown anti-inflammatory effect and has
a beneficial effect on clinical parameters in moderate to severe chronic
periodontitis patients.
AN - rayyan-563560259
AU - Al-Shammari, N. M.
AU - Shafshak, S. M.
AU - Ali, M. S.
DO - 10.5005/jp-journals-10024-2294
IS - 5
KW - beta defensin
biological marker
DEFB4A protein, human
hyaluronic acid
adult
controlled study
dental scaling
dose response
female
gel
gene expression
genetics
human
male
metabolism
middle aged
root planing
severity of illness index
time factor
treatment outcome
young adult
LA - English
PY - 2018
SN - 1526-3711
SP - 527-534
ST - Effect of 0.8% Hyaluronic Acid in Conventional Treatment of Moderate to
Severe Chronic Periodontitis
TI - Effect of 0.8% Hyaluronic Acid in Conventional Treatment of Moderate to
Severe Chronic Periodontitis
VL - 19
ID - 13633
ER -
TY - JOUR
AB - Thymoquinone (TQ), the active principle of Nigella sativa, has various
pharmacological properties. Aims: This study aimed to investigate TQ's potential
protective effect on caries initiation and gingival inflammation by inhibiting
plaque formation in rats' gingivitis model. Sixteen germ-free 21-day old Fischer
rats were randomly assigned to four groups, G1 - negative control consumed regular
diet without intervention; G2 - positive control consumed caries inducing food
(CID); G3 - consumed CID and treated by TQ oral gel; G4 - consumed CID and treated
by TQ aqueous solution. Experimental gingivitis and caries formation were done via
feeding animals a sucrose-rich diet after oral challenge with Streptococcus mutans.
Plaque index caries score, subgingival bacterial count, and bleeding on probing
were measured. Indicator dyes were used to evaluate plaque score and caries
fissures scores. Histological studies were conducted on mandibular arches to
determine the degree of inflammation. The results revealed that rats treated with
TQ as mouth gel or TQ aqueous solution showed less significant differences among
all parameters. The histological study showed a minimum or absence of inflammation
in gingival tissues. This study showed that treatment via TQ oral gel or TQ aqueous
solution reduced caries initiation, plaque formation, and gingival inflammation.
Therefore, it could be recommended for future toothpaste and mouthwash
manufactures.
AN - rayyan-563562626
AU - Al-Wafi, H.
AU - Ali, A. S.
AU - Loo, C. Y.
AU - Ali, S. S.
AU - Hur, Y.
AU - Harsono, M.
AU - Zoukhri, D.
IS - 3
PY - 2021
SN - ["1811-9506", "2218-3973"]
SP - 2142-2154
ST - Potential role of thymoquinone in management of Dental Caries and Gingival
disease in the animal model
T2 - BIOSCIENCE RESEARCH
TI - Potential role of thymoquinone in management of Dental Caries and Gingival
disease in the animal model
VL - 18
Y2 - 7
ID - 16000
ER -
TY - JOUR
AB - Periodontitis is a progressive inflammatory disease that affects roughly half
of American adults. Colonization of the oral cavity by the Gram-negative bacterial
pathogen Porphyromonas gingivalis is a key event in the initiation and development
of periodontal disease. Adhesive surface structures termed fimbriae (pili) mediate
interactions of P. gingivalis with other bacteria and with host cells throughout
the course of disease. The P. gingivalis fimbriae are assembled via a novel
mechanism that involves proteolytic processing of lipidated precursor subunits and
their subsequent polymerization on the bacterial surface. Given their extracellular
assembly mechanism and central roles in pathogenesis, the P. gingivalis fimbriae
are attractive targets for anti-infective therapeutics to prevent or treat
periodontal disease. Here we confirm that conserved sequences in the N and C
termini of the Mfa1 fimbrial subunit protein perform critical roles in subunit
polymerization. We show that treatment of P. gingivalis with peptides corresponding
to the conserved C-terminal region inhibits the extracellular assembly of Mfa
fimbriae on the bacterial surface. We also show that peptide treatment interferes
with the function of Mfa fimbriae by reducing P. gingivalis adhesion to
Streptococcus gordonii in a dual-species biofilm model. Finally, we show that
treatment of bacteria with similar peptides inhibits extracellular polymerization
of the Fim fimbriae, which are also expressed by P. gingivalis. These results
support a donor strand-based assembly mechanism for the P. gingivalis fimbriae and
demonstrate the feasibility of using extracellular peptides to disrupt the
biogenesis and function of these critical periodontal disease virulence factors.
AN - rayyan-563560198
AU - Alaei, S. R.
AU - Park, J. H.
AU - Walker, S. G.
AU - Thanassi, D. G.
DO - 10.1128/IAI.00750-18
IS - 3
KW - bacterial protein
glutathione
glutathione transferase
mfa1 protein
peptide derivative
signal peptide
unclassified drug
amino acid sequence
article
bacterial outer membrane
biogenesis
carboxy terminal sequence
confocal microscopy
conserved sequence
controlled study
crystal structure
fimbria
host cell
low temperature
microbial adhesion
molecular weight
nonhuman
polymerization
priority journal
protein assembly
protein stability
protein subunit
sequence homology
site directed mutagenesis
Streptococcus gordonii
surface property
LA - English
PY - 2019
SN - ["1098-5522", "0019-9567"]
ST - Peptide-based inhibitors of fimbrial biogenesis in Porphyromonas gingivalis
T2 - Infect. Immun.
TI - Peptide-based inhibitors of fimbrial biogenesis in Porphyromonas gingivalis
VL - 87
ID - 13572
ER -
TY - JOUR
AB - The oral cavity is a complex ecosystem accommodating various microorganisms
(e.g., bacteria and fungi). Various factors, such as diet change and poor oral
hygiene, can change the composition of oral microbiota, resulting in the dysbiosis
of the oral micro-environment and the emergence of pathogenic microorganisms, and
consequently, oral infectious diseases. Systemic administration is frequently used
for drug delivery in the treatment of diseases and is associated with the problems,
such as drug resistance and dysbiosis. To overcome these challenges, oral drug
delivery systems (DDS) have received considerable attention. In this literature
review, the related articles are identified, and their findings, in terms of
current therapeutic challenges and the applications of DDSs, especially nanoscopic
DDSs, for the treatment of oral infectious diseases are highlighted. DDSs are also
discussed in terms of structures and therapeutic agents (e.g., antibiotics,
antifungals, antiviral, and ions) that they deliver. In addition, strategies (e.g.,
theranostics, hydrogel, microparticle, strips/fibers, and pH-sensitive
nanoparticles), which can improve the treatment outcome of these diseases, are
highlighted.
AN - rayyan-563559795
AU - Alavi, S. E.
AU - Raza, A.
AU - Gholami, M.
AU - Giles, M.
AU - Al-Sammak, R.
AU - Ibrahim, A.
AU - Ebrahimi Shahmabadi, H.
AU - Sharma, L. A.
DO - 10.3390/pharmaceutics14112293
IS - 11
KW - fiber
0whistatin 5 peptide
antibiotic agent
antifungal agent
antivirus agent
apigenin
calcium
carbon dot
chlorhexidine
cyclodextrin
drug carrier
fluoride
fullerene derivative
glass ionomer
graphene
histatin 5
hydrogel
ion
ksl w peptide
microparticle
nanocarrier
nanoparticle
phosphate
polymer
strip
tinidazole
titanium dioxide
triclosan
unclassified drug
dental caries
Dodonaea viscosa
drug formulation
drug release
drug resistance
dysbiosis
human
infection control
Lavandula angustifolia
mouth flora
mouth infection
nonhuman
oral stimulus responsive drug delivery system
particle size
periodontitis
pH
review
thrush
treatment outcome
LA - English
PY - 2022
SN - 1999-4923
ST - Advanced Drug Delivery Platforms for the Treatment of Oral Pathogens
T2 - Pharmaceutics
TI - Advanced Drug Delivery Platforms for the Treatment of Oral Pathogens
VL - 14
ID - 13169
ER -
TY - JOUR
AN - rayyan-563561873
AU - Albandar, J. M.
DO - 10.1016/j.jebdp.2011.06.017
IS - 3
PY - 2011
SP - 137-140
ST - Adjunctive antibiotics with nonsurgical periodontal therapy improve the
clinical outcome of chronic periodontitis in current smokers
T2 - Journal of Evidence-Based Dental Practice
TI - Adjunctive antibiotics with nonsurgical periodontal therapy improve the
80051874496&doi=10.1016%2fj.jebdp.2011.06.017&partnerID=40&md5=8844b50d9619b247642d
32062bbfb55e
VL - 11
ID - 15247
ER -
TY - JOUR
AB - SELECTION CRITERIA: A systematic review was performed to identify randomized,
controlled, clinical trials designed to study the efficacy of adjunctive
antimicrobial therapy with periodontal treatment of chronic periodontitis in
smokers. A search was carried out using the databases PubMed (using MeSH terms and
free text), EMBASE, SCOPUS, and the Cochrane Central Register of Controlled
Clinical Trials, and a manual search of 4 periodontal journals, bibliographies,
review articles, and consensus statements. The databases were searched from their
earliest records until December 31, 2009. The inclusion criteria of studies were as
follows: (1) randomized, controlled clinical studies of ≥6 months study duration;
(2) application of a systemic or local adjunctive antimicrobial agent for the
treatment of chronic periodontitis in current smokers; (3) measurement of clinical
attachment level, probing depth, and bleeding on probing as primary outcomes; (4)
no periodontal treatment or use of systemic antibiotics within 6 months of the
start of the trial; and (5) publication in an English-language, peer-reviewed
journal. KEY STUDY FACTOR: The key intervention was the use of antibiotics as an
adjunct to nonsurgical or surgical periodontal treatment of chronic periodontitis
in current smokers. There were no limitations on the type of antibiotics used,
regimen, or the route of administration. MAIN OUTCOME MEASURE: The change in
clinical attachment level and probing depth ≥6 months postoperatively following
periodontal treatment. MAIN RESULTS: Five clinical trials met the inclusion
criteria and their findings were used in this systematic review. Nine additional
studies were excluded: 8 because smokers were not randomized, and 1 because the
follow-up was only 3 months. The age of subjects in the included studies ranged
from 42 to 52 years, and the sample size ranged from 30 to 181 subjects. Three
studies used nonsurgical periodontal therapy (scaling and root planing) (Table 1).
The first study used doxycycline 10% gel delivered locally and reported a gain in
attachment level 24 months postoperatively. The second study used minocycline 1-mg
microspheres delivered locally and reported a reduction in probing depth 9 months
postoperatively. In the third study, the experimental group was administered
azithromycin 250 mg systemically, and reported a gain in clinical attachment level
and a reduction in probing depth 6 months postoperatively. The fourth study used a
pocket reduction surgery and adjunctive use of systemic azithromycin 500 mg, and
found no significant reduction in probing depth or gain in attachment level 6
months postoperatively. The fifth study used surgical therapy consisting of guided
tissue regeneration (GTR) supplemented with local application of metronidazole 25%
gel for the treatment of Class II furcation defects. The latter study reported a
statistically significant gain in vertical attachment level but no significant
change in horizontal attachment level or probing depth during a 12-month follow-up
period. The risk of bias in all studies was estimated as high. The authors of the
systematic review stated that the reviewed data were inadequate and inconsistent,
and therefore meta-analyses were not performed. CONCLUSIONS: There is no sufficient
evidence in the literature to support or refute that adjunctive antibiotic therapy
would lead to a significant reduction in probing depth or gain in clinical
attachment level when treating periodontitis in smokers.
AN - rayyan-563561393
DO - 10.1016/S1532-3382(12)70015-5
IS - 3
J2 - J Evid Based Dent Pract
LA - eng
N1 - Periodontal Diagnostics Research Laboratory, Department of Periodontology and
Oral Implantology, Temple University School of Dentistry, 3223 North Broad Street,
Philadelphia, PA 19140, USA. albandar@temple.edu
PY - 2012
SP - 63-6
ST - Adjunctive antibiotics with nonsurgical periodontal therapy improve the
T2 - The journal of evidence-based dental practice
TI - Adjunctive antibiotics with nonsurgical periodontal therapy improve the
VL - 12
Y2 - 9
ID - 14767
ER -
TY - JOUR
AB - Chlorhexidine (CHX) is a compound with plaque-inhibiting effects and
available only by prescription in the United States. In Norway, however, CHX has
been dispensed over-the-counter for over 20 years, and this study was undertaken to
evaluate dentists' perceptions regarding its indications, usefulness, and side
effects. A written questionnaire was sent to a sample of 10% of dentists registered
in Norway, 78% of whom (354) responded. Additionally, representatives from 2% of
all dental practices in Norway were contacted by telephone. Fourteen percent (14%)
of the respondents reported that they never recommended CHX to their patients.
Among those recommending the compound, 85% used it frequently after surgical
periodontal procedures; 74% when treating acute gingivitis; 57% following oral
surgery in general; and 35% during non-surgical periodontal therapy. It was used
also as and adjunct to other treatment routines. Seventy-three percent (73%)
reported frequent use of CHX when treating stomatitis and 54% in herpes simplex
infections. As to side effects, 77% of the dentists indicated that staining of
teeth, restorations, and the tongue was a major concern to patients; 12% reported
inconveniences due to the bitter taste; and 6% reported other disturbances such as
dryness of the mouth and development of oral ulcerations. The majority (94%) of the
dentists recommended mouth rinsing, whereas 6% recommended a gel form. Only 4% of
the dentists recommended rinsing with a patient diluted 0.1% concentration, whereas
96% recommended the standard 0.2% formulation; 88% recommended using CHX mouthwash
twice a day or more often. It is concluded that CHX is used frequently in Norwegian
dental practices and that its use profile is diverse, though mainly as an anti-
plaque compound over a limited period of time when the use of other mechanical
measures is not feasible or sufficient.
AN - rayyan-563561081
AU - Gjermo, P.
AU - Preus, H. R.
DO - 10.1902/jop.1994.65.2.109
IS - 2
KW - chlorhexidine
article
drug efficacy
human
mouth hygiene
mouth ulcer
periodontal disease
taste disorder
tooth plaque
xerostomia
LA - English
PY - 1994
SN - 0022-3492
SP - 109-112
ST - Chlorhexidine use after two decades of over-the-counter availability
TI - Chlorhexidine use after two decades of over-the-counter availability
VL - 65
ID - 14455
ER -
TY - JOUR
AB - Introduction: Actinomyces naeslundii has been recovered from traumatized
permanent teeth diagnosed with necrotic pulps. In this work, a triple antibiotic
paste (TAP) mimic scaffold is proposed as a drug-delivery strategy to eliminate A.
naeslundii dentin biofilm. Methods: Metronidazole, ciprofloxacin, and minocydine
were added to a polydioxanone (PDS) polymer solution and spun into fibrous
scaffolds. Fiber morphology, mechanical properties, and drug release were
investigated by using scanning electron microscopy, microtensile testing, and high-
performance liquid chromatography, respectively. Human dentin specimens (4 x 4 x 1
mm(3), n = 4/group) were inoculated with A. naeslundii (ATCC 43146) for 7 days for
biofilm formation. The infected dentin specimens wete exposed to TAP-mimic
scaffolds, TAP solution (positive control), and pure PDS (drug-free scaffold).
Dentin infected (7-day biofilm) specimens were used for comparison (negative
control). Confocal laser scanning microscopy was done to determine bacterial
viability. Results: Scaffolds displayed a submicron mean fiber diameter (PDS = 689
+/- 12 nm and TAP-mimic = 718 +/- 125 nm). Overall, TAP-mimic scaffolds showed
significantly (P <= 040) lower mechanical properties than PDS. Within the first 24
hours, a burst release for all drugs was seen. A sustained maintenance of
metronidazole and ciprofloxacin was observed over 4 weeks, but not for minocycline.
Confocal laser scanning microscopy demonstrated complete elimination of all viable
bacteria exposed to the TAP solution. Meanwhile, TAP-mimic scaffolds led to a
significant (P < .05) reduction in the percentage of viable bacteria compared with
the negative control and PDS. Conclusions: Our findings suggest that TAP-mimic
scaffolds hold significant potential in the eradication/elimination of bacterial
biofilm, a critical step in regenerative endodontics.
AN - rayyan-563562603
AU - Albuquerque, M. T. P.
AU - Ryan, S. J.
AU - Munchow, E. A.
AU - Kamocka, M. M.
AU - Gregory, R. L.
AU - Valera, M. C.
AU - Bottino, M. C.
DO - 10.1016/j.joen.2015.03.005
IS - 8
PY - 2015
SN - ["0099-2399", "1878-3554"]
SP - 1337-1343
ST - Antimicrobial Effects of Novel Triple Antibiotic Paste-Mimic Scaffolds on
Actinomyces naeslundii Biofilm
T2 - JOURNAL OF ENDODONTICS
TI - Antimicrobial Effects of Novel Triple Antibiotic Paste-Mimic Scaffolds on
Actinomyces naeslundii Biofilm
VL - 41
Y2 - 8
ID - 15977
ER -
TY - JOUR
AN - rayyan-563561824
AU - Aleksić, M. D.
AU - Lukić, A. M.
DO - 10.5937/asn1674668A
IS - 74
PY - 2016
SP - 1668-1675
ST - Efficacy of gallium in tooth loss prevention
T2 - Acta Stomatologica Naissi
TI - Efficacy of gallium in tooth loss prevention
85018894597&doi=10.5937%2fasn1674668A&partnerID=40&md5=df63a178dcc5a41dec3358c1d2d8
3d0c
VL - 32
ID - 15198
ER -
TY - JOUR
AB - Simvastatin (SV) is a lipid lowering drug exhibits anti-inflammatory and
anabolic effects on the bone, so it could be utilized for the local treatment of
periodontitis. However, the poor solubility of SV limits its penetration through
the gingival sulcus. Encapsulating SV into microsponges may have the potential to
enhance the dissolution and subsequently its local penetration. In this study, SV
microsponges had been prepared using the emulsion-solvent evaporation technique
where, Eudragit RS-100 was employed as the polymer. The % encapsulation
efficiency(%EE) of drug approached 77.32 +/- 2.03. The prepared microsponges were
free flowing, spherical in shape having narrow size distribution range. The
particle size of the prepared microsponges was 93.79 +/- 7.21 mu m in diameter with
a small polydispersity index (PDI) of 0.0059 +/- 0.0008. In-vitro dissolution
studies of SV microsponges showed that the solubility of SV had significantly
enhanced upon inclusion inside the microsponges. Fourier transform infrared (FT-IR)
spectroscopy indicated hydrogen bond formation between SV and Eudragit RS-100. The
prepared microsponges were incorporated in chitosan 2% gels. A clinical study was
conducted on 24 selected patients having bony periodontal defects to compare the
efficacy of chitosan 2% gel containing free (SV) with that containing SV
microsponge in treatment of chronic periodontitis. Results showed that the chitosan
gels containing SV microsponges exhibited significant reduction in both pocket
depth and clinical attachment loss compared to those prepared with free SV. This
might be attributed to hydrogen bond formation between microsponges entrapped SV
and chitosan, thus microsponges are auspicious as a carrier for SV for local
treatment of periodontitis.
AN - rayyan-563562282
AU - Ali, A. U.
AU - Mortada, A.
AU - Safwat, M. A.
AU - El-Faham, T. H.
DO - 10.1016/j.jddst.2021.102583
PY - 2021
SN - ["1773-2247", "2588-8943"]
ST - Performance of simvastatin microsponges as a local treatment for chronic
periodontitis-Randomized clinical trial
T2 - JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
TI - Performance of simvastatin microsponges as a local treatment for chronic
periodontitis-Randomized clinical trial
VL - 64
Y2 - 8
ID - 15656
ER -
TY - JOUR
AB - Curcumin (CUR) is an ancient therapeutic agent with remarkable antimicrobial
and anti-inflammatory properties. The purpose of the current study was to
synthesize and evaluate a curcumin-based reparative endodontic material to reduce
infection and inflammation besides the induction of mineralization during the
healing of the dentin-pulp complex. Poly-e-caprolactone (PCL)/gelatin (Gel)/CUR
scaffold was synthesized and assessed by scanning electron microscopy, Fourier
transform infrared spectroscopy, and thermo-gravimetric analysis (TGA). Agar
diffusion test was performed against E. coli, A. baumannii, P. aeruginosa, S.
aureus, E. faecalis, and S. mutans. Moreover, proliferative, antioxidative, anti-
inflammatory, and calcification properties of these scaffolds on human dental pulp
stem cells (hDPSCs) were evaluated. The results showed that PCL/Gel/CUR scaffold
had antibacterial effects. Also, these CUR-based scaffolds had significant
inhibitory effects on the expression of tumor necrosis factor alpha and DCF from
inflamed hDPSCs (p < 0.05). Moreover, the induction of mineralization in hDPSCs
significantly increased after seeding on CUR-based scaffolds (p < 0.05). Based on
these findings, the investigated CUR-loaded material was fabricated successfully
and provided an appropriate structure for the attachment and proliferation of
hDPSCs. It was found that these scaffolds had antimicrobial, antioxidant, and anti-
inflammatory characteristics and could induce mineralization in hDPSCs, which is
essential for healing and repairing the injured dentin-pulp complex.
AN - rayyan-563562572
AU - Alipour, M.
AU - Fadakar, S.
AU - Aghazadeh, M.
AU - Salehi, R.
AU - Kafil, H. S.
AU - Roshangar, L.
AU - Mousavi, E.
AU - Aghazadeh, Z.
DO - 10.1002/jbt.22854
IS - 9
PY - 2021
SN - ["1095-6670", "1099-0461"]
ST - Synthesis, characterization, and evaluation of curcumin-loaded endodontic
reparative material
T2 - JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
TI - Synthesis, characterization, and evaluation of curcumin-loaded endodontic
reparative material
VL - 35
Y2 - 9
ID - 15946
ER -
TY - JOUR
AB - Curcumin (CUR) is an ancient therapeutic agent with remarkable antimicrobial
and anti-inflammatory properties. The purpose of the current study was to
synthesize and evaluate a curcumin-based reparative endodontic material to reduce
infection and inflammation besides the induction of mineralization during the
healing of the dentin–pulp complex. Poly-ɛ-caprolactone (PCL)/gelatin (Gel)/CUR
scaffold was synthesized and assessed by scanning electron microscopy, Fourier
transform infrared spectroscopy, and thermo-gravimetric analysis (TGA). Agar
diffusion test was performed against E. coli, A. baumannii, P. aeruginosa, S.
aureus, E. faecalis, and S. mutans. Moreover, proliferative, antioxidative, anti-
inflammatory, and calcification properties of these scaffolds on human dental pulp
stem cells (hDPSCs) were evaluated. The results showed that PCL/Gel/CUR scaffold
had antibacterial effects. Also, these CUR-based scaffolds had significant
inhibitory effects on the expression of tumor necrosis factor α and DCF from
inflamed hDPSCs (p < 0.05). Moreover, the induction of mineralization in hDPSCs
significantly increased after seeding on CUR-based scaffolds (p < 0.05). Based on
these findings, the investigated CUR-loaded material was fabricated successfully
and provided an appropriate structure for the attachment and proliferation of
hDPSCs. It was found that these scaffolds had antimicrobial, antioxidant, and anti-
inflammatory characteristics and could induce mineralization in hDPSCs, which is
essential for healing and repairing the injured dentin–pulp complex.
AN - rayyan-563559965
AU - Alipour, M.
AU - Fadakar, S.
AU - Aghazadeh, M.
AU - Salehi, R.
AU - Samadi Kafil, H.
AU - Roshangar, L.
AU - Mousavi, E.
AU - Aghazadeh, Z.
DO - 10.1002/jbt.22854
IS - 9
KW - culture medium
ELISA kit
ELISA reader
Mueller-Hinton agar
alkaline phosphatase
curcumin
gelatin
polycaprolactone
Acinetobacter baumannii
agar diffusion
article
calcification
cell proliferation
chemical analysis
clinical assessment
clinical evaluation
controlled study
cytotoxicity
dental pulp stem cell
dentin
drug synthesis
endodontics
Enterococcus faecalis
Escherichia coli
Fourier transform infrared spectroscopy
human
human cell
mineralization
restorative dentistry
Streptococcus mutans
thermogravimetry
tooth infection
tooth pulp
LA - English
PY - 2021
SN - ["1099-0461", "1095-6670"]
ST - Synthesis, characterization, and evaluation of curcumin-loaded endodontic
reparative material
T2 - J. Biochem. Mol. Toxicol.
TI - Synthesis, characterization, and evaluation of curcumin-loaded endodontic
reparative material
VL - 35
ID - 13339
ER -
TY - JOUR
AB - Background and Aim: Preclinical studies with proanthocyanidins (PACN) have
shown high antibacterial and anti-inflammatory capacities, that could reduce
periodontal inflammation. Recently, preclinical studies of our research group have
shown a specific antibacterial characteristic of PACN to attack periodontal
pathogens but save the oral commensal bacteria. The aim of current clinical study
was to evaluate the effectiveness of subgingivally placed collagen hydrogels with
PACN as an adjunct to subgingival instrumentation in patients with periodontitis.
Methods: Patients with stage III grade B periodontitis were included in this study.
Healthy individuals were enrolled as notreatment control. Patients with
periodontitis received two different treatment strategies: subgingival
instrumentation and subgingival application of collagen hydrogels with PACN (SP
group) compared with subgingival instrumentation (S) alone. Clinical periodontal
parameters (PPD, BI, PI) were evaluated before treatment and after 6 weeks. The
relationship of clinical periodontal parameters and immunological markers (MMP-3
and TIMP-1 levels) were analyzed to assess the efficacy of PACN in periodontal
therapy. This study is approved by the Regional Biomedical Research Ethics
Committee (No. BE-2-38). Trial Registration in ClinicalTrials.gov: NCT05015387.
Results: Totally, 70 systemically healthy individuals were enrolled in this study
(23 patients in S group, 23 patients in SP group, 24 patients in no-treatment
control group). Proanthocyanidins combined with subgingival instrumentation
resulted in additional statistically significant PPD reduction in moderate
periodontal pockets 0,5 mm (P < 0.05) on average compared to the subgingival
instrumentation alone. Immunological investigation showed that healthy individuals
had lower MMP-3 concentration in saliva compared to the patients with periodontitis
(P < 0.05). Application of PACN showed significant reduction of MMP-3 levels in
saliva after 6 weeks (P < 0.05). Conclusions: Adjunctive use of proanthocyanidins
in subgingival instrumentation resulted in better clinical outcomes for moderate
pockets. Additional use of proanthocyanidins improved MMP-3 concentration in saliva
more than subgingival instrumentation alone. Biochemical analysis revealed that
MMP-3 concentration in saliva reflected the periodontal health state.
AN - rayyan-563559835
AU - Alkimavičiene, E.
AU - Basevičiene, N.
AU - Pušinskaite, R.
DO - 10.1111/jcpe.13634
KW - collagen
endogenous compound
hydrogel
proanthocyanidin
stromelysin
tissue inhibitor of metalloproteinase 1
adult
biochemical analysis
clinical outcome
clinical trial
conference abstract
controlled study
drug efficacy
drug therapy
female
gene expression
health status
human
male
medical research
outcome assessment
periodontal parameters
periodontal pocket
periodontitis
periodontium
professional standard
LA - English
PY - 2022
SN - 1600-051X
SP - 25
ST - Effectiveness of adjunctive use of proanthocyanidins in non-surgical
periodontal treatment
TI - Effectiveness of adjunctive use of proanthocyanidins in non-surgical
periodontal treatment
VL - 49
ID - 13209
ER -
TY - JOUR
AB - Esthetics plays an important role in dentistry today. Because of an increased
emphasis on beauty and health, cosmetic dentistry has been the thrust to the
forefront of many practices. Many health products are used for bleaching teeth, but
all side effects are not known. Tooth sensitivity and gingival irritation are the
most common side effects, but they are typically mild and transient in nature. The
aim of this investigation was to evaluate objectively the effect of 10% carbamide
peroxide gel (Opalescence™ Utradent Inc, USA) on gingival health by measuring
changes in Bleeding Index, Plaque Index, and Gingival Index. Eighteen subjects, 11
female and 7 male, age range 15-30 years (mean 24 years), were selected for the
study as a convenient sample. Their teeth had either fluorosis, dental stains,
smoking, or tetracycline staining. The Opalescence system was used as office
monitored, at-home bleaching for three weeks. There was a statistically significant
reduction in bleeding on probing (1% - 37%, p < 0.003), Plaque Index (4% - 50%, p <
0.000), and Gingival Index (2.5% - 34%, p < 0.002). Only two subjects reported
tooth hypersensitivity, and none of the subjects complained about gingival
irritation. There was a positive change in tooth color as far as staining was
concerned. Further research including randomized controlled, double blind clinical
trials is needed to confirm these findings and to examine other factors related to
bleaching of teeth.
AN - rayyan-563560892
AU - Almas, K.
AU - Al-Harbi, M.
AU - Al-Gunaim, M.
IS - 1
KW - bleaching agent
peroxide
tetracycline
unclassified drug
urea derivative
carbamide peroxide
adolescent
adult
article
bleaching
bleeding
controlled study
dental procedure
dental health
female
fluorosis
gingiva disease
gingivitis
human
allergy
male
smoking
tooth color
tooth plaque
treatment outcome
Opalescence
LA - English
PY - 2003
SN - 1526-3711
SP - 30-37
ST - The effect of a 10% carbamide peroxide home bleaching system on thegingival
health
T2 - J. Contemp. Dental Pract.
TI - The effect of a 10% carbamide peroxide home bleaching system on thegingival
health
VL - 4
ID - 14266
ER -
TY - JOUR
AB - Injectable hydrogels (IHs) are smart biomaterials and are the most widely
investigated and versatile technologies, which can be either implanted or inserted
into living bodies with minimal invasion. Their unique features, tunable structure
and stimuli-responsive biodegradation properties make these IHs promising in many
biomedical applications, including tissue engineering, regenerative medicines,
implants, drug/protein/gene delivery, cancer treatment, aesthetic corrections and
spinal fusions. In this review, we comprehensively analyze the current development
of several important types of IHs, including all those that have received FDA
approval, are under clinical trials or are available commercially on the market. We
also analyze the structural chemistry, synthesis, bonding, chemical/physical
crosslinking and responsive release in association with current prospective re-
search. Finally, we also review IHs’ associated future prospects, hurdles,
limitations and challenges in their development, fabrication, synthesis, in situ
applications and regulatory affairs.
AN - rayyan-563559896
AU - Almawash, S.
AU - Osman, S. K.
AU - Mustafa, G.
AU - El Hamd, M. A.
DO - 10.3390/ph15030371
IS - 3
KW - NCT00629083
NCT00981006
NCT01077765
NCT01311791
NCT01372475
NCT01538628
NCT02187549
NCT02212548
NCT02224924
NCT02305602
NCT02525263
NCT02538991
NCT02550899
NCT02763956
NCT02776423
NCT02815046
NCT03060421
NCT03067090
NCT03082508
NCT03125226
NCT03223454
NCT03258541
NCT03307564
NCT03321396
NCT03630315
NCT03713021
NCT03897686
NCT04045431
NCT04061733
NCT04115345
NCT04120116
Bulkamid
collagen implant
contact lens
CosmoDerm
Cutimed
engineered bone graft
Evolence
external urethral occluder
Fibrel
fiducial marker
gauze dressing
Helix3-cm
Hyalofill
hydrogel dressing
hydrogel organ spacer
hyaluronic acid
INFUSE
injectable dermal implant
injectable implant
injectable incontinence implant
injectable knee implant
INTRASITE
Juvederm Ultra XC
Juvederm Vollure XC
Juvederm XC
Microcyn
povidone iodine dressing
hydroxyapatite
Revanesse Ultra
polylactic acid
soft contact lens
Tagaderm
transparent dressing
UFLEXXA
Viniferamine
wound dressing
amikacin
aminomethylpropanol
artificial tear
atrisorb d
benzocaine
bone morphogenetic protein 2
buccastem m
cancer vaccine
clotrimazole
copolymer
cyclosporine
dexamethasone
DNA vaccine
doxorubicin
doxycycline hyclate
fluocinolone acetonide
glucose
histrelin
hyaluronic acid plus lidocaine
hydrogel
hydroxyapatite plus lidocaine
hydroxypropylcellulose
injectable hydrogel
lidocaine
lubrajel
macrogol
naproxen
nicotine
nicotine gum
octreotide
ondansetron
op 1
osteogenic protein 1
ozone
poly(hexamethylenebiguanide)
prochlorperazine maleate
prontosan
purilon
regenecare
restylane injectable gel
restylane refyne
restylane silk
systane
unclassified drug
zilactin b gel
acromegaly
biocatalysis
biocompatibility
biodegradability
biomedical engineering
bone mineralization
bone regeneration
breast cancer
cancer immunotherapy
chemotherapy induced nausea and vomiting
click chemistry
complex formation
covalent bond
critical solution temperature
cross linking
diabetic macular edema
drug formulation
dry eye
encapsulation
gelation
good manufacturing practice
human
hydrogen bond
hydrophobicity
ionic strength
macular edema
Michael addition
mucoadhesion
nausea and vomiting
nonhuman
periodic acid Schiff stain
periodontitis
pH
polymerization
postoperative nausea and vomiting
precocious puberty
prostate cancer
radiation induced nausea and vomiting
review
sol-gel
temperature
tissue engineering
tissue regeneration
tissue repair
uveitis
wound closure
wound healing
atridox
belotero balance
iluvien
nicorette
nicotinell
ozurdex
radiesse
restasis
restylane defyne
restylane lyft
retisert
sandostatin
supprelin la
teosyal
vantas
yutiq
zuplenz
Air Optix
Algicell
Aquamid
AquaSite
Artefill
Belotero Balance
Biofinity
Coaptite
CosmoPlast
Elevess
HemCon
Hylaform
Inadine
Juvederm Volbella XC
Juvederm Voluma XC
Proclear
Radiesse
Revanesse Versa
Sculptra
SpaceOAR
TraceIT
Zyderm
Zyplast
LA - English
PY - 2022
SN - 1424-8247
ST - Current and Future Prospective of Injectable Hydrogels—Design Challenges and
Limitations
T2 - Pharmaceuticals
TI - Current and Future Prospective of Injectable Hydrogels—Design Challenges and
Limitations
VL - 15
ID - 13270
ER -
TY - JOUR
AB - Background: The purpose of this study was to determine the effect of the
active substance of three types of local delivery systems, doxycycline hyclate 10%
(DOXY), chlorhexidine gluconate, 2.5mg(CHX), andminocycline hydrochloride, 1mg
(MINO), on osteoblastic cell proliferation and differentiation. Methods: There were
four groups: control osteoblastic cells (OB) alone, OB + DOXY, OB + CHX, and OB +
MINO. Trypan blue and MTT [3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium
bromide] assays were used to test osteoblastic cell viability. Cell differentiation
was tested by measuring alkaline phosphatase levels. Osteoblast morphology was
investigated by light and scanning electron microscopy. Results: At a concentration
of 0.5 mg/ml, the Trypan blue test showed that DOXY,MINO, and CHX had significant
toxicity effects on osteoblast cells compared to the control group, with a mean
cell viability of 84%, 74%, and 51%, respectively (P <0.05). TheMTT test showed
that the control andDOXY groups were statistically significantly different (P
<0.05) compared to CHX andMINO groups. The DOXY group showed a significantly higher
alkaline phosphatase activity (;56%) than the control and MINO groups, and it was
nearly 178% higher than the CHX group (P <0.05). The morphology of the osteoblasts
seemed to be slightly altered when they were incubated with DOXY; however, with
MINO, they appeared rounded with minimal attachment. In the CHX group, the
osteoblasts assumed a shape of a very thin filopodia with a volcano-like nucleus.
Conclusions: At a concentration of 0.5mg/ml, CHX and, to a lesser extent,MINOhad a
cytotoxic effect on osteoblast proliferation in vitro. However, DOXY seemed to
enhance maturation and differentiation rather than proliferation. In addition
toDOXY's beneficial effect as an adjunctive therapy tomechanical debridement in the
treatment of periodontal disease, itmay have an effect on periodontal regeneration.
AN - rayyan-563560677
AU - Almazin, S. M.
AU - Dziak, R.
AU - Andreana, S.
AU - Ciancio, S. G.
DO - 10.1902/jop.2009.080574
IS - 6
KW - alkaline phosphatase
antiinfective agent
biological marker
chlorhexidine
coloring agent
diagnostic agent
doxycycline
doxycycline hyclate
drug carrier
drug derivative
microsphere
minocycline
tetrazolium
thiazole derivative
thiazolyl blue
trypan blue
article
cell adhesion
cell culture
cell nucleus
cell proliferation
cell shape
cell survival
drug effect
female
gel
human
male
middle aged
osteoblast
pseudopodium
LA - English
PY - 2009
SN - 0022-3492
SP - 999-1005
ST - The effect of doxycycline hyclate, chlorhexidine gluconate, and minocycline
hydrochloride on osteoblastic proliferation and differentiation in vitro
TI - The effect of doxycycline hyclate, chlorhexidine gluconate, and minocycline
hydrochloride on osteoblastic proliferation and differentiation in vitro
VL - 80
ID - 14051
ER -
TY - JOUR
AB - Objective: To compare 2 irrigation solutions in terms of postoperative pain
after single-visit treatment of chronic apical periodontitis with pulp necrosis.
Methods: A total of 126 patients requiring treatment of apical periodontitis and
pulp necrosis were randomly assigned to 2 groups according to the solution used for
irrigation: 5.25% sodium hypochlorite (NaOCl) or 2% chlorhexidine gel (CLX) (63
patients in each group). To assess postoperative pain, a questionnaire and pain
intensity scale were administered at 24, 48 and 72 hours and 7 days after the
procedure. The chi 2 test was used to compare the intensity of pain with the 2
irrigation solutions. Results: No patients reported severe pain at any stage.
Moderate pain was reported by 3% of patients (2/ 63 in each group) after 24 hours
and by no patients beyond 24 hours, regardless of the irrigant used. Mild pain was
more frequent but diminished rapidly (reported by 19% [ 12/63] of patients in the
NaOCl group and 16% [ 10/63] in the CLX group at 24 hours, by 10% [ 6/63] in the
NaOCl group and 11% [7/63] in the CLX group at 48 hours, by 3% [2/63] in both
groups at 72 hours and by 2% [ 1/63] in both groups at 7 days). There were no
statistically significant differences in postoperative pain between the 2 groups at
any time point (p > 0.05). Conclusions: The incidence of postoperative pain after
single-visit endodontic treatment of chronic apical periodontitis with pulp
necrosis was uniformly low, regardless of the irrigant used. The success of
endodontic treatment is directly associated with infection control.(1-5) The
literature indicates that rotary, hand or hybrid instrumentation, even when
performed correctly, is inadequate to clear all organic and inorganic debris from
the root canal system.(6-8) For this and other reasons, irrigating solutions play
an important role, making up for the shortcomings of instrumentation and
complementing endodontic disinfection procedures.(8) Sodium hypochlorite (NaOCl)
solution is the standard irrigant for cleansing and disinfection of the root canal.
(3) It has antimicrobial and histolytic characteristics, among other properties.(9)
However, NaOCl may be cytotoxic to the periradicular tissues, particularly at high
concentrations.(10,11) As such, postoperative pain is a concern when highly
concentrated NaOCl solutions are used in single-visit treatment of nonvital teeth
because of the risk of extravasation of the irrigant into these tissues.(12) Some
investigators have suggested 2% chlorhexidine gel (CLX) as a good choice of
irrigant for necrotic teeth because of its antimicrobial action, high substantivity
and low toxicity.(13,14) In addition, CLX may be less caustic than NaOCl. 12
However, Mohammadi and Abbott(5) reported that despite acceptable biocompatibility,
CLX is also potentially cytotoxic and may induce allergic reactions, though rarely.
Direct comparison of NaOCl and CLX in a randomized clinical trial, in terms of
their influence on postoperative pain, was therefore warranted. The study described
here involved in vivo assessment of the incidence of postoperative pain after
single-visit endodontic treatment of patients with radiographically visible chronic
apical periodontitis and necrotic pulp, with either 5.25% NaOCl or 2% CLX plus
normal saline (0.9% NaCl) as the irrigant.
AN - rayyan-563562558
AU - Almeida, G.
AU - Marques, E.
AU - De Martin, A. S.
AU - Bueno, C. E. D.
AU - Nowakowski, A.
AU - Cunha, R. S.
PY - 2012
SN - 1488-2159
ST - Influence of Irrigating Solution on Postoperative Pain Following Single-Visit
Endodontic Treatment: Randomized Clinical Trial
T2 - JOURNAL OF THE CANADIAN DENTAL ASSOCIATION
TI - Influence of Irrigating Solution on Postoperative Pain Following Single-Visit
Endodontic Treatment: Randomized Clinical Trial
VL - 78
Y2 - 9 y3 - 7
ID - 15932
ER -
TY - JOUR
AB - To compare 2 irrigation solutions in terms of postoperative pain after
single-visit treatment of chronic apical periodontitis with pulp necrosis. A total
of 126 patients requiring treatment of apical periodontitis and pulp necrosis were
randomly assigned to 2 groups according to the solution used for irrigation: 5.25%
sodium hypochlorite (NaOCl) or 2% chlorhexidine gel (CLX) (63 patients in each
group). To assess postoperative pain, a questionnaire and pain intensity scale were
administered at 24, 48 and 72 hours and 7 days after the procedure. The χ2 test was
used to compare the intensity of pain with the 2 irrigation solutions. No patients
reported severe pain at any stage. Moderate pain was reported by 3% of patients
(2/63 in each group) after 24 hours and by no patients beyond 24 hours, regardless
of the irrigant used. Mild pain was more frequent but diminished rapidly (reported
by 19% [12/63] of patients in the NaOCl group and 16% [10/63] in the CLX group at
24 hours, by 10% [6/63] in the NaOCl group and 11% [7/63] in the CLX group at 48
hours, by 3% [2/63] in both groups at 72 hours and by 2% [1/63] in both groups at 7
days). There were no statistically significant differences in postoperative pain
between the 2 groups at any time point (p > 0.05). The incidence of postoperative
pain after single-visit endodontic treatment of chronic apical periodontitis with
pulp necrosis was uniformly low, regardless of the irrigant used.
AN - rayyan-563560517
AU - Almeida, G.
AU - Marques, E.
AU - De Martin, A. S.
AU - da Silveira Bueno, C. E.
AU - Nowakowski, A.
AU - Cunha, R. S.
KW - biomedical and dental materials
chlorhexidine
resin cement
gutta percha
hypochlorite sodium
obtura II
resin
root canal filling material
adolescent
adult
article
chemistry
comparative study
controlled study
dental surgery
endodontics
devices
female
follow up
human
male
methodology
middle aged
pain assessment
pathology
postoperative pain
prospective study
tooth periapical disease
tooth pulp
tooth pulp disease
tooth root
young adult
LA - English
PY - 2012
SN - 1488-2159
SP - c84
ST - Influence of irrigating solution on postoperative pain following single-visit
endodontic treatment: randomized clinical trial
T2 - J Can Dent Assoc
TI - Influence of irrigating solution on postoperative pain following single-visit
endodontic treatment: randomized clinical trial
VL - 78
ID - 13891
ER -
TY - JOUR
AB - OBJECTIVES: This study compared the clinical effects of a full-mouth
disinfection (FMD) protocol for the treatment of mild-to-moderate periodontitis in
type 2 diabetic and non-diabetic subjects for up to 1 year. Secondary aim was to
evaluate the effects of this therapy on the salivary levels of periodontal
pathogens between diabetics and non-diabetics. MATERIAL AND METHODS: Twenty-six
type 2 diabetic subjects and 28 non-diabetic subjects with mild-to-moderate
periodontitis received full-mouth scaling and root planing within 24 h, application
of chlorhexidine digluconate (CHX) gel in pockets and tongue plus CHX rinses for 14
days. Clinical monitoring was performed at baseline, 3, 6, and 12 months post-
therapy. Salivary levels of red complex bacterial species were evaluated at
baseline, 6, and 12 months post-therapy by qPCR. RESULTS: Intention-to-treat
analyses were performed for seven diabetics and three non-diabetics that did not
return for the 12-month evaluation. Most clinical parameters improved significantly
at 3, 6, and 12 months post-therapies for both groups (p < 0.05). Overall, there
were no significant differences in clinical parameters between groups after therapy
(p > 0.05). At 1 year, 39.3% and 50.0% of the non-diabetic and diabetic subjects,
respectively, achieved the desired clinical endpoint for treatment (≤ 4 sites with
probing depth ≥ 5 mm) (primary outcome variable) (p > 0.05). FMD did not promote
changes in the salivary levels of pathogens in either of the groups (p > 0.05).
Levels of T. forsythia were lower in diabetic than in non-diabetic subjects at 6
months post-therapy (p < 0.05). CONCLUSIONS: Type 2 diabetic subjects and
systemically healthy subjects with mild-to-moderate periodontitis responded
similarly to the proposed FMD protocol for up to 1 year. CLINICAL RELEVANCE: There
is a general thought that diabetics do not answer as well as non-diabetics to
periodontal treatments. However, this study showed that diabetics and non-diabetics
respond equally to the FMD protocol. TRIAL REGISTRATION: ClinicalTrials.gov
Identifier: NCT02643771.
AN - rayyan-563560157
AU - Almeida, M. L.
AU - Duarte, P. M.
AU - Figueira, E. A.
AU - Lemos, J. C.
AU - Nobre, C. M. G.
AU - Miranda, T. S.
AU - de Vasconcelos Gurgel, B. C.
DO - 10.1007/s00784-019-02927-8
IS - 1
KW - NCT02643771
chlorhexidine
dental scaling
disinfection
female
human
male
periodontal index
periodontitis
procedures
root planing
LA - English
PY - 2020
SN - 1436-3771
SP - 333-341
ST - Effects of a full-mouth disinfection protocol on the treatment of type-2
diabetic and non-diabetic subjects with mild-to-moderate periodontitis: one-year
clinical outcomes
T2 - Clin Oral Investig
TI - Effects of a full-mouth disinfection protocol on the treatment of type-2
diabetic and non-diabetic subjects with mild-to-moderate periodontitis: one-year
clinical outcomes
VL - 24
ID - 13531
ER -
TY - JOUR
AB - OBJECTIVE: This study aims to evaluate the effects of topical hyaluronic acid
(HA), hypochlorous acid (HOCl), and flurbiprofen on postoperative morbidity of
palatal donor sites after free gingival graft (FGG) surgery. MATERIALS AND METHODS:
Sixty patients requiring FGG were randomly assigned into four groups: control, HA
gel (600 mg/100 g high molecular weight hyaluronic acid), HOCl spray (170-200 ppm,
ph7.1), flurbiprofen spray (0.075gr flurbiprofen). Topical agents were applied for
14 days, according to groups. Patients were followed for 28 days. Palatal healing
was assessed with the Laundry wound healing index (WHI). Complete epithelization
(CE) was evaluated with photographs and H2O2 bubbling. Pain, burning sensation,
chewing efficacy, and tissue color match (CM) were evaluated using a visual analog
scale (VAS). Postoperative analgesic consumption and delayed bleeding (DB) were
also recorded. RESULTS: HA provided better WHI values on the 7th, 14th, and 21st
days compared to the other groups, respectively (p < 0.05). CE was formed on the
21st day in the HA group but on the 28th day in the other groups. HOCl and
flurbiprofen groups were not different from the control group or each other in
terms of WHI. HOCl had the lowest VAS scores of all time periods. DB was not
observed in any group. Significantly fewer analgesics were taken in the topical
agent-applied groups compared to the control group. CONCLUSIONS: HA exhibits a
positive impact on the epithelization of palatal wound healing and color matching.
HOCl and flurbiprofen provided less pain; however, they might have negative effects
on palatal wound healing. CLINICAL RELEVANCE: As a result of obtaining free
gingival grafts from palatal tissue for mucogingival surgical procedures, secondary
wound healing of the donor area occurs. This wound in the palatal region can cause
discomfort and pain every time patients use their mouths. The use of HA can reduce
postoperative complications by accelerating wound healing and reducing pain. The
topical use of flurbiprofen and HOCl can reduce patients' pain.
AN - rayyan-563559711
AU - Alpan, A. L.
AU - Cin, G. T.
DO - 10.1007/s00784-022-04848-5
IS - 6
KW - flurbiprofen
hyaluronic acid
hydrogen peroxide
hypochlorous acid
controlled study
gingiva
human
morbidity
palate
postoperative pain
surgery
transplantation
LA - English
PY - 2023
SN - 1436-3771
SP - 2735-2746
ST - Comparison of hyaluronic acid, hypochlorous acid, and flurbiprofen on
postoperative morbidity in palatal donor area: a randomized controlled clinical
trial
TI - Comparison of hyaluronic acid, hypochlorous acid, and flurbiprofen on
postoperative morbidity in palatal donor area: a randomized controlled clinical
trial
VL - 27
ID - 13085
ER -
TY - JOUR
AB - Objective: The aim of this 1-year follow-up randomized control trial was to
compare the clinicoradiographic status of implants that were disinfected with
antimicrobial photodynamic therapy (aPDT) and 0.2% chlorhexidine gel immediately
before prosthesis delivery. Methods: Forty-five partially edentulous patients with
implants placed in the region of missing mandibular first molars and a history of
periodontal diseases were included. Immediately before prosthesis delivery,
patients were divided into three groups. In groups 1 and 2, implant abutment
disinfection (IAD) was performed using aPDT and 0.2% chlorhexidine immediately
before prosthesis delivery. In Group-3, IAD was performed using a steaming
protocol. Peri-implant modified plaque index (mPI), modified gingival index (mGI),
probing depth (PD) and crestal bone loss (CBL) were assessed at 1 year of follow-
up. Power analysis was done and group comparisons were done. Logistic regression
analysis was done to corelate clinical parameters with demographic variables.
P<0.01 was considered statistically significant. Results: In total, 15, 15, and 15
implants were present among patients in groups 1, 2 and 3, respectively. There was
no statistically significant difference in peri-implant mPI, mBoP, PD and CBL in
all groups (Table 2). None of the patients had periodontal disease and there was no
statistically significant correlation between peri-implant clinicoradiographic
parameters with age, toothbrushing and flossing habits, and duration of implants in
function. Eighty percent, 86.7% and 100% individuals in groups 1, 2 and 3,
respectively reported that they were brushing teeth twice daily. Flossing of
interproximal spaces once daily was reported by 66.7%, 73.3% and 66.7% individuals
in groups 1, 2 and 3, respectively. Conclusion: As long as oral hygiene is
stringently maintained after implant prosthesis delivery, IAD can be performed
using aPDT, 0.2% CHX gel or steam-disinfection.
AN - rayyan-563559832
AU - Alresheedi, B.
AU - Alazmi, S.
DO - 10.1016/j.pdpdt.2022.102790
KW - dental abutment
dental floss
dental laser
digital radiography device
NOMAD/Pro-2
SPSS-Version 22
chlorhexidine
methylene blue
adult
alveolar bone loss
antimicrobial photodynamic therapy
article
clinical article
controlled study
data analysis software
disinfection
edentulous jaw
female
follow up
gingival index
habit
human
male
mandibular first molar
middle aged
mouth hygiene
osseointegration
periodontal disease
plaque index
prosthesis implantation
steam sterilization
tooth brushing
tooth radiography
LA - English
PY - 2022
SN - ["1873-1597", "1572-1000"]
ST - Disinfection of implant abutment connection using antimicrobial photodynamic
therapy and 0.2% chlorhexidine gel applications immediately before prosthesis
delivery: Clinical and radiographic status at 1-year of follow-up
T2 - Photodiagn. Photodyn. Ther.
TI - Disinfection of implant abutment connection using antimicrobial photodynamic
therapy and 0.2% chlorhexidine gel applications immediately before prosthesis
delivery: Clinical and radiographic status at 1-year of follow-up
VL - 38
ID - 13206
ER -
TY - JOUR
AB - OBJECTIVE: The purpose of this five-year follow-up study was to investigate
the clinical and radiologic status of implants that had undergone abutment
disinfection immediately prior to prosthetic loading (PL) using plasma of argon
(PA) or 0.2% chlorhexidine (CHX) gel. PATIENTS AND METHODS: Sixty patients who had
had an implant-supported prosthesis fitted at least five years previously were
recruited for this study. In groups 1, 2, and 3, implant abutment disinfection was
performed using PA, 0.2% CHX, and a vapor protocol, respectively. Modified plaque
index (mPI), modified bleeding index (mBI), probing depth (PD), and mesial and
distal crestal bone loss (CBL) were measured. A questionnaire on routine oral
hygiene, smoking habits, and systemic health status was also administered. Sample
size estimation was performed, and group comparisons were made. Probability values
less than 0.05 were considered statistically significant. RESULTS: Group 1, 2, and
3 included 20 (20 implants) patients each. At five-year’s follow-up, there was no
difference in mBI, mPI, and PD in all groups. There was no significant difference
in peri-implant CBL in all patients. None of the patients were immunosuppressed or
had periodontal disease, and or had used nicotinic products within the past five
years. Toothbrushing twice daily was reported by at least 90% of individuals in all
groups. Flossing of interproximal spaces once daily was reported by at minimum 60%
of individuals in all groups. CONCLUSIONS: Disinfection of implant abutments
directly before PL can be performed using AP, or 0.2% CHX gel.
AN - rayyan-563559767
AU - Alsahhaf, A.
AU - Alrabiah, M.
AU - Ali, K.
AU - Vohra, F.
AU - Abduljabbar, T.
DO - 10.26355/eurrev_202301_30861
IS - 1
argon
chlorhexidine
gel
plasma of argon
unclassified drug
adult
article
bleeding index
clinical feature
controlled study
crestal bone loss
demographics
disinfection
female
flossing
follow up
health status
human
male
middle aged
mouth hygiene
patient coding
patient selection
periodontal disease
plaque index
probability
questionnaire
sample size
smoking habit
tooth brushing
tooth implantation
tooth radiography
vapor
LA - English
PY - 2023
SN - ["2284-0729", "1128-3602"]
SP - 116-121
ST - Implant abutment disinfection using plasma of argon and 0.2% and
chlorhexidine gel applications immediately before prosthesis delivery: clinical and
radiographic status at 5-years of follow-up
T2 - Eur. Rev. Med. Pharmacol. Sci.
TI - Implant abutment disinfection using plasma of argon and 0.2% and
chlorhexidine gel applications immediately before prosthesis delivery: clinical and
radiographic status at 5-years of follow-up
VL - 27
ID - 13141
ER -
TY - JOUR
AB - The interaction of lactoferrin with Actinobacillus actinomycetemcomitans was
examined in a I-125-labeled protein binding assay. The binding of human and bovine
lactoferrins reached maximum within 1 h. Lactoferrin binding to the bacterium was
pH-dependent and reversible. Scatchard analysis indicated the existence of two
different types of binding sites on the bacterium, one with a high affinity
constant k(alpha)approximate to 8.8x10(-7) M) and the other with a low one
(k(alpha)approximate to 1.8x10(-6) M). Bacteria in the exponential phase of growth
showed higher binding than cells in the stationary phase. Bacteria grown in medium
containing serum and/or lysed erythrocytes bound lactoferrin to a lesser extent.
Heat-inactivated serum, lysed erythrocytes and other proteins such as mucin and
laminin inhibited lactoferrin binding to A. actinomycetemcomitans in a competitive
binding assay. Sodium dodecyl sulfate polyacrylamide-gel electrophoresis and
Western blot analysis of the cell envelope as well as the outer membrane of A.
actinomycetemcomitans revealed lactoferrin-reactive protein bands at 29 kDa and
16.5 kDa. The 29-kDa band displayed a heat-modifiable lactoferrin-reactive form
with a molecular weight of 34 kDa. Neither proteinase K-treated cell envelope nor
lipopolysaccharide of this bacterium showed reactivity with lactoferrin. These data
suggests a specific interaction of lactoferrin with outer membrane proteins of A.
actinomycetemcomitans.
AN - rayyan-563562637
AU - Alugupalli, K. R.
AU - Kalfas, S.
AU - Edwardsson, S.
AU - Naidu, A. S.
IS - 1
PY - 1995
SN - 0902-0055
SP - 35-41
ST - LACTOFERRIN INTERACTION WITH ACTINOBACILLUS-ACTINOMYCETEMCOMITANS
TI - LACTOFERRIN INTERACTION WITH ACTINOBACILLUS-ACTINOMYCETEMCOMITANS
VL - 10
Y2 - 2
ID - 16011
ER -
TY - JOUR
AN - rayyan-563561617
AU - Alvarez Echazú, M. I.
AU - Antona, M. E.
AU - Perna, O.
AU - Olivetti, C. E.
AU - Alvarez, G. S.
AU - Macri, E. V.
AU - Perez, C. J.
AU - Czerner, M.
AU - Friedman, S. M.
AU - Desimone, M. F.
DO - 10.1002/app.51432
IS - 1
PY - 2022
ST - Dodecenylsuccinic anhydride modified chitosan hydrogels for the sustained
delivery of hydrophobic drugs. The case of thymol buccal delivery
T2 - Journal of Applied Polymer Science
TI - Dodecenylsuccinic anhydride modified chitosan hydrogels for the sustained
delivery of hydrophobic drugs. The case of thymol buccal delivery
85110549951&doi=10.1002%2fapp.51432&partnerID=40&md5=72f610b2e70d91b254b8d375d2b522
29
VL - 139
ID - 14991
ER -
TY - JOUR
AB - Nowadays, the research of innovative drug delivery devices is focused on the
design of multiple drug delivery systems, the prevention of drug side effects and
the reduction of dosing intervals. Particularly, new mucosal delivery systems for
antimicrobials, antioxidants and anti-inflammatory drugs has a growing development,
regards to the avoidance of side effects, easy administration and a suitable drug
concentration in the mucosa. In this work, chitosan hydrogels are evaluated as a
biodegradable scaffold and as a bioactive agent carrier of an antioxidant-
antimicrobial compound called thymol. Throughout the study, swelling behavior,
viscoelastic properties and thermal analysis are highlighted to present its
advantages for a biomedical application. Furthermore, the in vitro results obtained
indicate that thymol-chitosan hydrogels are biocompatible when exposed to [3T3]
fibroblasts, exhibit antimicrobial activity against Staphylococcus aureus and
Streptococcus mutans for 72h and antioxidant activity for 24h. These are desirable
properties for a mucosal delivery system for an antimicrobial-antioxidant dual
therapy for periodontal disease.
AN - rayyan-563560278
AU - Anesini, C.
AU - Perez, C. J.
AU - Alvarez, G. S.
DO - 10.1016/j.msec.2017.08.059
antioxidant
chitosan
thymol
chemistry
human
hydrogel
LA - English
PY - 2017
SN - 1873-0191
SP - 588-596
ST - Development and evaluation of thymol-chitosan hydrogels with antimicrobial-
antioxidant activity for oral local delivery
T2 - Mater Sci Eng C Mater Biol Appl
TI - Development and evaluation of thymol-chitosan hydrogels with antimicrobial-
antioxidant activity for oral local delivery
VL - 81
ID - 13652
ER -
TY - JOUR
AB - Severe periodontitis represents a priority in oral care. It's the sixth most
prevalent condition worldwide, which affects 10% of the population. This advanced
stage of periodontal disease characterized for the formation of dental pockets and
gingival tissue recession could lead to tooth loss. Thymol chitosan hydrogels
exemplifies a possible alternative for a biodegradable oral delivery device for
severe periodontitis treatment which would also serve as a scaffold for periodontal
tissue regeneration. Oxidative stress is known to be involved in periodontitis
pathogenesis. Thymol release, a phenol compound with antioxidant properties, could
help as a supplementary therapy agent. Antioxidant agents have already been added
in many dental products, such as oral rinses and toothpastes. Thymol chitosan
hydrogels showed in vitro antioxidant activity after 24hs, carried out through the
DPPH assay, which analyses free radical scavenging activity. Thymol release was
determinated by the Folin-Ciocalteu method using as release medium modified
Fuyasama-Meyer artificial saliva. Chitosan hydrogels were characterized by scanning
electron microscopy. It was observed that thymol in vitro release from chitosan
hydrogels in artificial saliva preserved its antioxidant characteristics. Thymol
antioxidant therapy could decrease periodontal inflammation through its free
radical scavenging activity.
AN - rayyan-563560411
AU - Morcillo, M. F.
AU - Anesini, C.
AU - Alvarez, G. S.
KW - chitosan
thymol
antioxidant
saliva substitute
free radical
toothpaste
phenol derivative
hydrogel
devices
society
molecular biology
periodontitis
in vitro study
periodontal disease
therapy
tissues
population
pathogenesis
oxidative stress
inflammation
DPPH radical scavenging assay
tissue regeneration
mouth hygiene
LA - English
PY - 2015
SN - 0327-9545
ST - Chitosan hydrogels: An alternative for a biodegradable oral delivery device
T2 - Biocell
TI - Chitosan hydrogels: An alternative for a biodegradable oral delivery device
VL - 39
ID - 13785
ER -
TY - JOUR
AN - rayyan-563561742
AU - Alves, M. C. C.
AU - Chaves, D. S. A.
AU - Benevenuto, B. R.
AU - De Farias, B. O.
AU - Coelho, S. M. O.
AU - Ferreira, T. P.
AU - Pereira, G. A.
AU - Dos Santos, G. C. M.
AU - Moreira, L. O.
AU - Freitas, J. P.
AU - Cid, Y. P.
DO - 10.1590/0001-3765202020200562
IS - 4
PY - 2020
SP - 1-10
ST - Chitosan gels for buccal delivery of schinus molle l. Essential oil in dogs:
Characterization and antimicrobial activity in vitro
T2 - Anais da Academia Brasileira de Ciencias
TI - Chitosan gels for buccal delivery of schinus molle l. Essential oil in dogs:
Characterization and antimicrobial activity in vitro
85096440983&doi=10.1590%2f0001-
3765202020200562&partnerID=40&md5=026c2789b35fe05a36591d1b7291b41d
VL - 92
ID - 15116
ER -
TY - JOUR
AB - Periodontal disease is considered the main oral cavity disorder in dogs.
Essential oils have the potential for use in the prevention and treatment of oral
diseases. The antimicrobial activity of Schinus molle L. essential oil (SMEO) has
already been reported. Chitosan, a natural product with antimicrobial activity and
good biocompatibility has potential in biodental applications. In this study, we
evaluated the in vitro antimicrobial activity of SMEO against bacteria associated
with periodontal disease in dogs, developed and evaluated the physicochemical
properties of a novel chitosan-based buccal delivery system containing SMEO. SMEO
showed antimicrobial activity against Gram positive and Gram negative bacteria
associated with canine periodontitis, with MIC values of 750 mu g.mL(-1) for
Staphylococcus spp. and Streptococcus spp, 1000 mu g.mL(-1) for Corynebacterium
spp. and 1250 mu g.mL(-1) for Pseudomonas spp. All formulations evaluated presented
adequate physicochemical properties, good stability, and pH values close to buccal
pH (5.0-7.0). Chitosan gel loaded with SMEO showed potential as a SMEO delivery
system, having the ideal physicochemical and rheological properties (pseudoplastic
and apparent viscosities) required for application on buccal tissue. Thus, we can
conclude that formulation has the potential to be used for buccal mucosa delivery
in the prevention and treatment of periodontal disease in dogs.
AN - rayyan-563562279
AU - De Farias, B. O.
AU - Pereira, G. A.
AU - Dos Santos, G. C. M.
AU - Moreira, L. O.
AU - Freitas, J. P.
AU - Cid, Y. P.
DO - 10.1590/0001-3765202020200562
IS - 4
PY - 2020
SN - ["0001-3765", "1678-2690"]
ST - Chitosan gets for buccal delivery of Schinus molle L. essential oil in dogs:
characterization and antimicrobial activity in vitro
T2 - ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
TI - Chitosan gets for buccal delivery of Schinus molle L. essential oil in dogs:
VL - 92
ID - 15653
ER -
TY - JOUR
AB - Periodontal disease is considered the main oral cavity disorder in dogs.
Essential oils have the potential for use in the prevention and treatment of oral
diseases. The antimicrobial activity of Schinus molle L. essential oil (SMEO) has
already been reported. Chitosan, a natural product with antimicrobial activity and
good biocompatibility has potential in biodental applications. In this study, we
evaluated the in vitro antimicrobial activity of SMEO against bacteria associated
with periodontal disease in dogs, developed and evaluated the physicochemical
properties of a novel chitosan-based buccal delivery system containing SMEO. SMEO
showed antimicrobial activity against Gram positive and Gram negative bacteria
associated with canine periodontitis, with MIC values of 750 µg.mL-1 for
Staphylococcus spp. and Streptococcus spp, 1000 µg.mL-1 for Corynebacterium spp.
and 1250 µg.mL-1 for Pseudomonas spp. All formulations evaluated presented adequate
physicochemical properties, good stability, and pH values close to buccal pH (5.0-
7.0). Chitosan gel loaded with SMEO showed potential as a SMEO delivery system,
having the ideal physicochemical and rheological properties (pseudoplastic and
apparent viscosities) required for application on buccal tissue. Thus, we can
conclude that formulation has the potential to be used for buccal mucosa delivery
in the prevention and treatment of periodontal disease in dogs.
AN - rayyan-563560162
AU - Farias, B. O.
AU - Pereira, G. A.
AU - Santos, G. C. M. D.
AU - Moreira, L. O.
AU - Freitas, J. P.
AU - Cid, Y. P.
DO - 10.1590/0001-3765202020200562
IS - 4
chitosan
essential oil
Anacardiaceae
animal
dog
gel
LA - English
PY - 2020
SN - 1678-2690
SP - e20200562
ST - Chitosan gels for buccal delivery of Schinus molle L. essential oil in dogs:
T2 - An Acad Bras Cienc
TI - Chitosan gels for buccal delivery of Schinus molle L. essential oil in dogs:
VL - 92
ID - 13536
ER -
TY - JOUR
AB - The purpose of this article is to report a protocol for treating an
orthodontic patient with a high risk of developing caries. The salivary level of
Streptococcus mutans was evaluated during various stages of orthodontic treatment.
It was significantly high before professional application of 1% chlorhexidine
collagen gel, daily mouth rinsing with 0.05% sodium fluoride solution, and bonding
of the bands and brackets. Although there were no other changes in hygiene habits,
microbiologic tests showed that the microbiota was in balance during the follow-up
periods. At the end of orthodontic treatment, periodontal health was observed, and
enamel surfaces showed signs of remineralization. © 2008 American Association of
Orthodontists.
AN - rayyan-563560726
AU - Alves, P. V. M.
AU - Alviano, W. S.
AU - Bolognese, A. M.
AU - Nojima, L. I.
DO - 10.1016/j.ajodo.2006.03.031
IS - 1
KW - anticaries agent
chlorhexidine
collagen
sodium fluoride
adolescent
article
bacterial count
clinical protocol
dental caries
drug effect
gel
human
devices
malocclusion
microbiology
mouthwash
orthodontic device
orthodontics
risk
saliva
tooth plaque
LA - English
PY - 2008
SN - 0889-5406
SP - 91-94
ST - Treatment protocol to control Streptococcus mutans level in an orthodontic
patient with high caries risk
T2 - Am. J. Orthod. Dentofacial Orthop.
TI - Treatment protocol to control Streptococcus mutans level in an orthodontic
patient with high caries risk
VL - 133
ID - 14100
ER -
TY - JOUR
AN - rayyan-563561180
AU - Alzate Alzate, L. M.
AU - Otero, F.
IS - 162
KW - chlorhexidine
adult
article
comparative study
gel
human
mouth hygiene
periodontics
periodontitis
tooth plaque
LA - Spanish
PY - 1987
SN - 0046-354X
SP - 35-48
ST - Comparative study of 3 different commercial forms of chlorhexidine in equal
concentration (0.2%)
T2 - Estudio comarativo de la clorhexidina en tres diferentes presentaciones
comercial y en iqual concentración (0.2%).
TI - Comparative study of 3 different commercial forms of chlorhexidine in equal
concentration (0.2%)
VL - 37
ID - 14554
ER -
TY - JOUR
AN - rayyan-563561472
AU - Amalina, R.
AU - Ardhani, R.
AU - Yusuf, Y.
AU - Susilowati, H.
IS - 2
PY - 2023
SP - 588-593
ST - Fabrication and Physicochemical Properties of a Novel Gel-Like Liquid
Chitosan-Carbonated Hydroxyapatite from Asian Moon Scallop (Amusium Pleuronectes)
for Periodontal Application
TI - Fabrication and Physicochemical Properties of a Novel Gel-Like Liquid
Chitosan-Carbonated Hydroxyapatite from Asian Moon Scallop (Amusium Pleuronectes)
for Periodontal Application
85165139372&partnerID=40&md5=79c687047f7a5d369a82e97db00e847c
VL - 16
ID - 14846
ER -
TY - JOUR
AB - BACKGROUND: Many techniques have been evolved for the purpose of managing
discoloured non-vital tooth such as dental bleaching, restorative and prosthetic
treatment. In order to achieve better control on the patients, in-office and intra-
coronal bleaching procedures were introduced in clinical practice. Such techniques
usually use higher whitening agent concentrations activated by means of heat or
light sources, resulting in improved color stability in the long term. The aim of
this study was to evaluate the color stability, after 25 years, of endodontically-
treated teeth subjected to in-office and walking bleach dental treatments with
carbamide peroxide. METHODS: A population of patients with a single endodontic
treatment on an incisor teeth was recruited. All the teeth selected for the study
were subjected to both in-office intra-coronal dental bleaching and walking bleach
technique with 10% carbamide peroxide gel. The patients were recalled at follow-up
every 12 months for a total observational period of 25 years. RESULTS: After 25
years of clinical service on 40 patients, an optimal tooth color stability in
relation to adjacent teeth was evidenced in 34 patients, while 6 patients were
classified as failures, since a color mismatch of two or more shades were noticed.
Consequently, a success rate of 85% was reported after 25 years. CONCLUSIONS: Ten
percent carbamide peroxide proved to be an effective dental whitening agent in the
long-term for endodontically-treated.
AN - rayyan-563560229
AU - Amato, A.
AU - Caggiano, M.
AU - Pantaleo, G.
AU - Amato, M.
DO - 10.23736/S0026-4970.18.04190-0
IS - 6
KW - Coltosol
root canal obturator
carbamide peroxide
dental material
Opalescence
tooth bleaching agent
unclassified drug
adult
anamnesis
article
barotrauma
clinical assessment
dental caries
dental procedure
endodontic procedure
female
follow up
gingivectomy
gingivitis
human
male
observational study
oroantral fistula
osteolysis
photography
prosthodontics
retrospective study
tooth cementum
tooth color
tooth discoloration
tooth injury
tooth pain
tooth pulp disease
tooth radiography
treatment failure
walking bleach
LA - English
PY - 2018
SN - ["1827-174X", "0026-4970"]
SP - 225-230
ST - In-office and walking bleach dental treatments on endodontically-treated
teeth: 25 years follow-up
T2 - Minerva Stomatol.
TI - In-office and walking bleach dental treatments on endodontically-treated
teeth: 25 years follow-up
VL - 67
ID - 13603
ER -
TY - JOUR
AB - Periodontitis is an inflammatory disease of the gums characterized by the
degeneration of periodontal ligaments, the formation of periodontal pockets, and
the resorption of the alveolar bone, which results in the destruction of the
teeth’s supporting structure. Periodontitis is caused by the growth of diverse
microflora (particularly anaerobes) in the pockets, releasing toxins and enzymes
and stimulating the immune system. Various approaches, both local and systemic,
have been used to treat periodontitis effectively. Successful treatment depends on
reducing bacterial biofilm, bleeding on probing (BOP), and reducing or eliminating
pockets. Currently, the use of local drug delivery systems (LDDSs) as an adjunctive
therapy to scaling and root planing (SRP) in periodontitis is a promising strategy,
resulting in greater efficacy and fewer adverse effects by controlling drug
release. Selecting an appropriate bioactive agent and route of administration is
the cornerstone of a successful periodontitis treatment plan. In this context, this
review focuses on applications of LDDSs with varying properties in treating
periodontitis with or without systemic diseases to identify current challenges and
future research directions.
AN - rayyan-563559729
AU - Amato, M.
AU - Santonocito, S.
AU - Polizzi, A.
AU - Tartaglia, G. M.
AU - Ronsivalle, V.
AU - Viglianisi, G.
AU - Grippaudo, C.
AU - Isola, G.
IS - 4
KW - amoxicillin
antibiotic agent
azithromycin
chitosan
chlorhexidine
curcumin
doxycycline
erythropoietin
hydrogel
hydroxymethylglutaryl coenzyme A reductase inhibitor
interleukin 17
interleukin 1beta
metronidazole
microsphere
minocycline
nanofiber
nutraceutical
poly(methyl methacrylate)
polyhydroxybutyric acid
tetracycline
toxin
alveolar bone loss
anaerobe
biocompatibility
biofilm
bleeding
bleeding on probing
bone defect
controlled release formulation
destruction
disk diffusion
drug release
encapsulation
human
immune system
inflammation
inflammatory disease
mesenchymal stem cell
microflora
periodontitis
randomized controlled trial (topic)
review
systemic disease
three-dimensional imaging
thrombocyte rich plasma
tooth
LA - English
PY - 2023
SN - 1999-4923
ST - Local Delivery and Controlled Release Drugs Systems: A New Approach for the
Clinical Treatment of Periodontitis Therapy
T2 - Pharmaceutics
TI - Local Delivery and Controlled Release Drugs Systems: A New Approach for the
Clinical Treatment of Periodontitis Therapy
VL - 15
ID - 13103
ER -
TY - JOUR
AB - PURPOSE: A randomized controlled trial was conducted to evaluate the clinical
efficacy of a two-step dentifrice/whitening gel oral hygiene sequence on natural
gingivitis and extrinsic stain. METHODS: The population consisted of healthy adults
with clinical evidence of gingivitis and extrinsic stain. Consent, demographic
information and clinical measurements were collected, after which subjects were
randomized to treatment. Eligible subjects were dispensed blinded test kits
containing over-labeled two-step 0.454% SnF₂ dentifrice then 3% H₂O₂ whitening gel
sequence or a regular 0.76% NaMFP dentifrice control (Colgate Cavity Protection),
plus a regular soft manual toothbrush and instructions for use. Efficacy was
assessed blind-to-treatment using the Gingivitis Bleeding Index (GBI) measured
whole-mouth and the composite Lobene Stain Index (LSI) measured on the anterior
dentition. Treatments were compared at Week 1 and Week 3 versus baseline for ΔGBI
and ΔLSI using a two-sided 5% level of significance. RESULTS: A total of 61
subjects with a mean (SD) age of 33.4 (12.0) years were enrolled. Overall baseline
means (SD) were 0.16 (0.05) for GBI and 1.30 (0.94) for LSI. After 1 week, only the
two-step 0.454% SnF₂ dentifrice then 3% H₂ O₂ whitening gel sequence demonstrated
significant (P< 0.0001) reductions in both gingivitis and stain. Adjusted means for
the changes with the dentifrice/gel sequence and control were -0.055 and -0.001 for
ΔGBI, and -0.619 and -0.095 for ΔLSI, with groups differing significantly (P<
0.0001) on gingivitis and stain improvement. Outcomes at Week 3 were generally
similar, with groups differing on bleeding and stain. Treatments were generally
well-tolerated. CLINICAL SIGNIFICANCE: In a randomized controlled trial, use of a
two-step 0.454% SnF₂ dentifrice then 3% H₂ O₂ whitening gel sequence yielded
concurrent improvements in gingivitis and stain compared to regular oral hygiene.
AN - rayyan-563560250
AU - Amini, P.
AU - Amini, A.
AU - Gerlach, R. W.
KW - coloring agent
hydrogen peroxide
sodium fluoride
toothpaste
adult
clinical trial
controlled study
dental procedure
gel
gingivitis
human
tooth discoloration
treatment outcome
LA - English
PY - 2018
SN - 0894-8275
SP - 13A-17A
ST - Randomized controlled trial evaluating concurrent gingivitis and stain
effects of a two-step dentifrice/gel sequence
T2 - Am J Dent
TI - Randomized controlled trial evaluating concurrent gingivitis and stain
effects of a two-step dentifrice/gel sequence
VL - 31
ID - 13624
ER -
TY - JOUR
AB - This study aimed to develop a dual action, namely anti-inflammatory and
antimicrobial, nanogels (NG) for the treatment of periodontitis using triclosan
(TCS) and flurbiprofen (FLB). Triclosan, an antimicrobial drug, was prepared as
nanoparticles (NPs) using poly-ε-caprolactone (PCL), while flurbiprofen, an anti-
inflammatory drug, was directly loaded in a chitosan (CS) based hydrogel. The
entwinement of both NPs and hydrogel loaded systems resulted in the NG. The
characterisation data confirmed that the developed formulation consists of
nanosized spherical structures and displays pH-dependent swelling/erosion and
temperature-responsiveness. Besides, the NG exhibited adequate bioadhesiveness
using the chicken pouch model and displayed antibacterial activity through the agar
plate method. An in-vivo study of the NG on experimental periodontitis (EP) rats
confirmed the dual antibacterial and anti-inflammatory effects which revealed an
excellent therapeutic outcome. In conclusion, a dual action NG was successfully
developed and proved to have superior therapeutic effects in comparison to physical
mixtures of the individual drugs.
AN - rayyan-563560174
AU - Aminu, N.
AU - Chan, S. Y.
AU - Yam, M. F.
AU - Toh, S. M.
DO - 10.1016/j.ijpharm.2019.118659
KW - chitosan
flurbiprofen
gentamicin
polycaprolactone
triclosan
vancomycin
adhesion
animal experiment
animal model
article
chemical structure
comparative study
controlled study
dispersity
drug formulation
Escherichia coli
gingival index
hydrogel
in vivo study
male
nanopharmaceutics
nonhuman
particle size
pH
plaque index
priority journal
rat
temperature dependence
treatment outcome
zeta potential
zone of inhibition
LA - English
PY - 2019
SN - ["1873-3476", "0378-5173"]
ST - A dual-action chitosan-based nanogel system of triclosan and flurbiprofen for
localised treatment of periodontitis
T2 - Int. J. Pharm.
TI - A dual-action chitosan-based nanogel system of triclosan and flurbiprofen for
localised treatment of periodontitis
VL - 570
ID - 13548
ER -
TY - JOUR
AB - Nanoparticles (NPs)-hydrogel composite (nanogels) have yielded a surge in the
design and development of novel drug delivery systems for the treatment of many
ailments, including periodontal disease. The recent innovations in
nanotechnological drug carrier systems seem promising, as it provides a means to
improve the bioavailability of poorly soluble drugs, formulations of controlled and
targeted drug delivery systems, and drug release control based on the stimuli
response, among others. Several polymeric NPs-hydrogel coformulations have been
investigated during the last few years, mostly using synthetic and natural
polymers. Some of the results and rewards achieved from these novel approaches are
the use of bioadhesive polymers to achieve prolonged drug release, the increment of
intra-pocket drug penetration, the enhancement of mechanical properties using
chemical crosslinkers, and the possibility of loading multiple drugs in a unit
delivery system. Furthermore, these nanotechnological advances have also shown that
NPs possess great potential as drug carriers in periodontal disease treatment. The
future utilization of these advantages will significantly improve dental care. The
coformulation of NPs-hydrogel composite will yield additional benefits that are
much greater than ordinary NPs or hydrogels in delivering of drug into the
periodontal pockets. The aim of this review article is to summarize updates on the
current and future nanotechnological approaches that are being investigated for the
treatment of periodontitis, with particular attention to the nanogels, and to
identify arenas which its exploration might lead to the development of effective
intra-pocket drug delivery systems for the treatment of periodontal diseases. The
review also provides brief applications of nanogels in the management of other
diseases.
AN - rayyan-563560312
AU - Aminu, N.
AU - Toh, S. M.
DO - 10.22159/ajpcr.2017.v10i2.15709
IS - 2
KW - 2 methacryloyloxyethylphosphorylcholine
4,4' isopropylidenediphenol
chlorhexidine
ciprofloxacin
diclofenac
doxycycline
fluorouridine
glycerol derivative
methacrylic acid
metronidazole
metronidazole benzoate
minocycline
nanoparticle
ofloxacin
penicillin G
secnidazole
tetracycline
titanium dioxide
triclosan
zinc oxide
bioavailability
biocompatibility
drug formulation
drug solubility
human
hydrogel
hydrophilicity
hydrophobicity
microemulsion
nanotechnology
periodontal disease
periodontitis
protein cross linking
review
water content
LA - English
PY - 2017
SN - ["2455-3891", "0974-2441"]
SP - 65-70
ST - Applicability of nanoparticles-hydrogel composite in treating periodontal
diseases and beyond
T2 - Asian J. Pharm. Clin. Res.
TI - Applicability of nanoparticles-hydrogel composite in treating periodontal
diseases and beyond
VL - 10
ID - 13686
ER -
TY - JOUR
AB - Purpose: To evaluate therapeutic effectiveness of antibacterial triclosan
(TCS) and anti-inflammatory flurbiprofen (FLB)-loaded nanogels system in ligature-
induced experimental periodontitis in rats. Methodology: A total of 72 Sprague–
Dawley rats were used in this study. Four groups (n = 18 each) were randomly
created: Group 1 – neither subjected to experimental periodontitis nor to any
treatment; Group 2 – subjected to experimental periodontitis but not treated; Group
3 – subjected to experimental periodontitis and then treated with the developed
nanogels; Group 4 – subjected to experimental periodontitis and then placed on a
mixture of pure TCS and FLB treatment. The experimental periodontitis was induced
on the lower incisors by applying a ligature which was kept for 14 days. Treatment
was done for 7 days, and sampling was done at 7, 14, and 28 day of the post-
induction experimental period. Morphometric analysis was conducted to assess the
clinical outcomes and healing effect. Results: The morphometric findings showed
that the group treated with the developed TCS and FLB-loaded nanogels recovered
better and faster than a mixture of pure TCS and FLB. At 28 day of the experimental
period, there was no significant difference (p > 0.05) between the baseline control
group and the nanogels treated group. Conclusions: The developed TCS and FLB-loaded
nanogels was found to be effective in the treatment of experimental periodontitis
in rats. The used experimental periodontitis model was found to be simple and
easily reproducible.
AN - rayyan-563559943
AU - Aminu, N.
AU - Yam, M. F.
AU - Chan, S. Y.
AU - Bello, I.
AU - Umar, N. M.
AU - Nuhu, T.
AU - Toh, S. M.
DO - 10.1016/j.sdentj.2020.08.008
IS - 7
KW - operating table
stereoscope
amobarbital
flurbiprofen
nanogel
pentobarbital
triclosan
alveolar bone
alveolar bone loss
alveolar crest
animal euthanasia
animal experiment
animal model
article
biofilm
clinical outcome
controlled study
drug efficacy
drug mixture
enamel
general anesthesia
healing
incisor
lethal dose
male
mandible
morphology
morphometry
nonhuman
osteolysis
rat
Sprague Dawley rat
dorminal
LA - English
PY - 2021
SN - 1013-9052
SP - 554-559
ST - The evaluation of healing effect of triclosan and flurbiprofen-loaded
nanogels in experimental periodontitis in rats by morphometric analysis
T2 - Saudi Dent. J.
TI - The evaluation of healing effect of triclosan and flurbiprofen-loaded
nanogels in experimental periodontitis in rats by morphometric analysis
VL - 33
ID - 13317
ER -
TY - JOUR
AB - Tissue engineering applications could benefit from simultaneous release of
growth factors, signaling molecules, and antibiotics to obtain optimal healing of
tissues. Elastin-like polypeptides (ELPs) are genetically engineered polymers that
possess good biocompatibility, are biodegradable, and exhibit mechanical properties
similar to natural elastin. In addition, ELPs exhibit a characteristic inverse
phase transition temperature (Tt). This T t behavior is widely exploited in
hyperthermia mediated drug delivery. The objectives of this research were to
prepare ELP hydrogel scaffolds using a novel ultrasonication method and to
investigate the release of a model protein (bovine serum albumin, BSA) and a
commonly used antibiotic in periodontal therapy (doxycycline) from the scaffolds at
two different temperatures (25 °C<Tt vs. 37 °C>Tt). Both BSA and doxycycline showed
a gradual time dependent release and showed a trend of higher release fractions
with higher loading doses. Based on the comparison between the release profiles at
the two selected temperatures, the release was higher at 37 °C compared to that at
25 °C for both the loading concentrations of doxycycline (0.05 and 0.1 % v/v) and
only one of the loading concentrations of BSA (0.5 % v/v) studied, while the
release was higher at 25 °C compared to that at 37 °C only for the other loading
concentration of BSA (1 % v/v) studied. These results suggested that the drug
molecular weight and loading concentration were significant factors that affected
the release kinetics. The experiments in this study demonstrated that the ELP
hydrogel scaffolds can successfully release proteins and antibiotics critical to
tissue engineering. © Springer Science+Business Media, LLC 2012.
AN - rayyan-563560518
AU - Amruthwar, S. S.
AU - Janorkar, A. V.
DO - 10.1007/s10856-012-4749-5
IS - 12
KW - bovine serum albumin
doxycycline
elastin
elastin like polypeptide
polymer
polypeptide
unclassified drug
article
biocompatibility
biodegradability
biomechanics
controlled study
drug release
hydrogel
hyperthermia
kinetics
molecular weight
nonhuman
phase transition
priority journal
temperature
tissue engineering
ultrasound
LA - English
PY - 2012
SN - ["0957-4530", "1573-4838"]
SP - 2903-2912
ST - Preparation and characterization of elastin-like polypeptide scaffolds for
local delivery of antibiotics and proteins
T2 - J. Mater. Sci. Mater. Med.
TI - Preparation and characterization of elastin-like polypeptide scaffolds for
local delivery of antibiotics and proteins
VL - 23
ID - 13892
ER -
TY - JOUR
AB - Outer membrane vesicles (OMVs) of bacteria harbor physiologically active
molecules, and quorum sensing inhibitors (QSIs) are expected to regulate bacterial
virulence. In this study, we analyzed the proinflammatory activity of OMVs of the
periodontal pathogen Tannerella forsythia treated with d-arabinose and d-galactose
as QSIs, which inhibit the biofilm formation of periodontal pathogens and
autoinducer 2 activity. Compared to OMVs of nontreated T. forsythia (TF OMVs), OMVs
released from QSI-treated T. forsythia, designated TF ara-OMVs and TF gal-OMVs,
showed reduced production of TNF-α, IL-1β, IL-6, and IL-8 in THP-1 monocytes
through decreased activation of NF-κB/MAPKs. Using a human NF-κB reporter cell line
and bone marrow-derived macrophages from TLR2−/− mice, TF ara-OMVs and TF gal-OMVs
showed less activation of TLR2 than TF OMVs. These results demonstrated that QSIs
provide a dual advantage against bacterial infection by inhibiting bacterial
biofilm formation and generating OMVs with reduced proinflammatory activity.
AN - rayyan-563559750
AU - An, S. J.
AU - Ha, K. W.
AU - Jun, H. K.
AU - Kim, H. Y.
AU - Choi, B. K.
DO - 10.1111/omi.12380
IS - 1
KW - arabinose
galactose
interleukin 10
interleukin 1beta
interleukin 4
interleukin 6
interleukin 8
mitogen activated protein kinase
toll like receptor 2
animal experiment
article
bacterial infection
biofilm
bone marrow derived macrophage
C57BL 6 mouse
confocal laser scanning microscopy
controlled study
cytokine production
inflammation
intracellular signaling
membrane vesicle
mouse
nonhuman
outer membrane
pathogenesis
periodontitis
protein expression
quorum sensing
real time polymerase chain reaction
THP-1 cell line
Western blotting
LA - English
PY - 2023
SN - ["2041-1014", "2041-1006"]
SP - 71-81
ST - Reduced proinflammatory activity of outer membrane vesicles of Tannerella
forsythia treated with quorum sensing inhibitors
TI - Reduced proinflammatory activity of outer membrane vesicles of Tannerella
forsythia treated with quorum sensing inhibitors
VL - 38
ID - 13124
ER -
TY - JOUR
AB - Periodontitis is a destructive inflammatory disease of the periodontium
induced by specific microorganisms and requires more specific treatment. The
traditional mechanical therapy alone is not sufficient for the treatment of
moderate to severe periodontitis because of in accessibility in the deep
periodontal pocket and depth of penetration of microorganisms into the periodontal
connective tissues. Thus to overcome the limitations of mechanical therapy, local
drug delivery into the periodontal pocket is recommended. The local drug delivery
of chemotherapeutic agents to the periodontal lesion site has the advantage of
loading a higher concentration of drug at the target site minimizing the adverse
effect of the drug on the other systems of the body. The local drug delivery system
having controlled release should be considered as an adjunctive to mechanical
debridement for the treatment of periodontal diseases. This article reviews local
drug delivery systems containing antimicrobial agents. Further extensive
comparative studies are required to optimize the use of novel drugs in the local
drug delivery system to manage periodontal diseases.
AN - rayyan-563559969
AU - Anarthe, R.
AU - Kale, P.
AU - Mani, A.
AU - Kendre, S.
DO - 10.13040/IJPSR.0975-8232.12(9).4616-25
IS - 9
KW - fiber
film
chemical agent
chlorhexidine
curcumin
doxycycline
gel
glycoside
herbaceous agent
liposome
lupeol
metronidazole
microsphere
minocycline
nanoparticle
satranidazole
tea tree oil
tetracycline
Aloe vera
article
coriander
Cymbopogon citratus
experimental therapy
human
nonhuman
oak
ointment
periodontitis
pomegranate
tea
LA - English
PY - 2021
SN - ["0975-8232", "2320-5148"]
SP - 4616-4625
ST - Local drug delivery in periodontitis: An innovative treatment modality
T2 - Int. J. Pharm. Sci. Res.
TI - Local drug delivery in periodontitis: An innovative treatment modality
VL - 12
ID - 13343
ER -
TY - JOUR
AN - rayyan-563561595
AU - Andriani, I.
AU - Medawati, A.
AU - Humanindito, M. I.
AU - Nurhasanah, M.
DO - 10.20473/j.djmkg.v55.i2.p93-98
IS - 2
PY - 2022
SP - 93-98
ST - The effect of antimicrobial peptide gel RISE-AP12 on decreasing neutrophil
and enhancing macrophage in nicotine-periodontitis Wistar rat model
T2 - Dental Journal
TI - The effect of antimicrobial peptide gel RISE-AP12 on decreasing neutrophil
and enhancing macrophage in nicotine-periodontitis Wistar rat model
85132509917&doi=10.20473%2fj.djmkg.v55.i2.p93-
98&partnerID=40&md5=2cfda6ef776124c083144eee075c3a17
VL - 55
ID - 14969
ER -
TY - CPAPER
AB - Nicotine, a major component of tobacco, is a significant contributing factor
for the exacerbation of periodontal diseases. Periodontitis, one of the periodontal
diseases, leads to alveolar bone damage triggered by bacteria and exacerbated by
nicotine exposure as mostly suffered by smokers. Periodontitis treatment requires
an antibacterial for the regeneration process; antimicrobial peptide gel (AMP) has
a broad-spectrum antimicrobial that is rarely resistant. This study aims to
determine the effect of antimicrobial peptide gel on the regeneration process of
periodontitis in rat models exposed to nicotine by observing the number of
angiogenesis and fibroblast cells. Twenty-four Wistar rats were divided into four
groups based on nicotine exposure, the control group and treated rats.
Periodontitis was induced by ligation on the mandibular central incisor for 14
days, and the periodontitis rats were treated with AMP on their sulcus of gingiva
on day 1, 3, and 7. On day 3, 7, and 14 after treatment, two rats were taken
randomly in each group for decapitation, followed by histological processing and
examination with Hematoxylin-Eosin. The non-parametric statistic test of Kruskal-
Wallis revealed that the value of p=0,000 for angiogenesis and p=0,001 for
fibroblast showed significant difference (p <0,05) between the treated and control
groups in both groups with and without exposure to nicotine. Conclusion: The high
number of angiogenesis and fibroblast cells in treated rats indicated that the
Antimicrobial Peptide Gel successfully accelerated periodontitis' regeneration
process in rat models exposed to nicotine.
AN - rayyan-563562010
AU - Andriani, I.
AU - Rahmawati, A. D.
AU - Nurhasana, M.
AU - Humanindito, M. I.
PY - 2021
SP - 172-176
T2 - PROCEEDINGS OF THE 4TH INTERNATIONAL CONFERENCE ON SUSTAINABLE INNOVATION
2020 - HEALTH SCIENCE AND NURSING (ICOSIHSN 2020)
TI - The Effects of Antimicrobial Peptide Gel on Angiogenesis and Fibroblast Cells
in Periodontal Tissue Regeneration in a Periodontitis Rats Model Exposed by
Nicotine
VL - 33
ID - 15384
ER -
TY - JOUR
AB - Background: The aim of this study is to systematically review the evidence of
the efficacy of adjunctive antibiotic therapy to periodontal therapy in smokers
with periodontitis. Methods: A search was conducted for randomized clinical trials
(RCTs) with durations ≥6 months that compared periodontal therapy with and without
adjunctive antibiotics for the treatment of periodontitis in smokers. Data sources
primarily included PubMed with MeSH terms and free text as well as EMBASE, SCOPUS,
and the Cochrane Central Register of Controlled Clinical Trials. In addition, a
hand search of selected periodontal journals, bibliographies, and review articles
was conducted. Independent reviewers were assigned to make independent searches and
quality assessments (MA and DB) of the included studies, and disagreements were
resolved by discussion. Results: Five RCTs were selected for quantitative and
qualitative assessments. Little evidence was found that supported the use of
antibiotic therapy in conjunction with surgical periodontal therapy in smokers.
With respect to non-surgical therapy, consistent improvements in clinical
attachment level (CAL) gain and probing depth (PD) reduction was reported after the
use of a 250-mg azithromycin tablet in one study. Adjunctive doxycycline gel and
minocycline microspheres statistically improved CAL gain (in one RCT) and PD
reduction (in one RCT), respectively. However, the risk of bias in all studies was
estimated as high. Also, inadequate and inconsistent data precluded performing
meta-analyses. Conclusions: The present systematic review concludes that the
evidence for an additional benefit of adjunctive antibiotic therapy in smokers with
chronic periodontitis is insufficient and inconclusive. Additional well-designed
RCTs are required to assess the effect of antibiotics in conjunction with
periodontal treatments in smokers.
AN - rayyan-563560623
AU - Angaji, M.
AU - Gelskey, S.
AU - Nogueira-Filho, G.
AU - Brothwell, A. D.
DO - 10.1902/jop.2010.100192
IS - 11
human
periodontal disease
periodontal pocket
review
smoking
treatment outcome
LA - English
PY - 2010
SN - 0022-3492
SP - 1518-1528
ST - A systematic review of clinical efficacy of adjunctive antibiotics in the
treatment of smokers with periodontitis
TI - A systematic review of clinical efficacy of adjunctive antibiotics in the
treatment of smokers with periodontitis
VL - 81
ID - 13997
ER -
TY - JOUR
AB - BACKGROUND OF THE STUDY: The aim of this study is to evaluate the efficacy of
natural curcumin in the management of chronic periodontitis as local drug delivery
in comparison to synthetic chlorhexidine, which is the gold standard. MATERIALS AND
METHODS: Thirty chronic periodontitis patients with an age range of 20-50 years
with probing pocket depth (PPD) of 4-6 mm were included. Curcumin and chlorhexidine
gel was applied in the contralateral disease sites at baseline and day 15. The
clinical parameters like PPD, clinical attachment level (CAL), gingival index (Loe
and Silness) and plaque index (Turesky Gillmore modification of Quigley Hein) were
recorded and colony forming units (CFU) were assessed microbiologically at
baseline, 15 and 30 days. RESULTS: There was a significant reduction of the
clinical parameters (PPD, CAL) and microbiological parameters CFU at 15 and 30 days
for both the groups. Curcumin group showed a greater reduction in the clinical
parameters when compared with chlorhexidine group. Both groups had a significant
reduction in parameters when compared with baseline. CONCLUSION: Although curcumin
has equivalent benefit to chlorhexidine, curcumin being an ayurvedic herb is an
excellent alternative to chlorhexidine due to minimal side-effects.
AN - rayyan-563560409
AU - Anitha, V.
AU - Rajesh, P.
AU - Shanmugam, M.
AU - Priya, B. M.
AU - Prabhu, S.
AU - Shivakumar, V.
DO - 10.4103/0970-9290.156806
IS - 1
KW - chlorhexidine
curcumin
enzyme inhibitor
gel
adult
comparative study
controlled study
female
human
male
microbiology
middle aged
periodontal index
periodontal pocket
plaque index
treatment outcome
LA - English
PY - 2015
SN - 1998-3603
SP - 53-56
ST - Comparative evaluation of natural curcumin and synthetic chlorhexidine in the
management of chronic periodontitis as a local drug delivery: a clinical and
microbiological study
T2 - Indian J Dent Res
TI - Comparative evaluation of natural curcumin and synthetic chlorhexidine in the
management of chronic periodontitis as a local drug delivery: a clinical and
microbiological study
VL - 26
ID - 13783
ER -
TY - JOUR
AB - Background:The elimination of the pathogenic microorganisms of the
periodontal pocket is one of the main points for success in periodontal treatment.
The objective of this study is to investigate the clinical and antimicrobial effect
of papain-mediated photodynamic therapy in the clinical treatment of periodontal
disease.Methods:Twenty patients with chronic periodontitis will be selected.
Patients will be randomly divided into 2 groups (n=10). Group 1 will receive
conventional periodontal treatment and group 2 will receive conventional treatment
and antimicrobial photodynamic therapy (PACT). Conventional treatment will consist
of oral hygiene guidance, with brushing technique instructions and recommendation
of daily flossing. The calculus deposits on the teeth will be removed with
ultrasound equipment and curettes for scraping and root planning. The PACT will be
performed at the end of each periodontal treatment session, at sites with bags
≥4mm. PapaMblue photosensitizer will be deposited in the periodontal pockets with a
syringe and a pre-irradiation time of 1minute will be adopted. Then, the laser
emitting wavelength of 660nm, with power of 100mW, for 2minutes, radiant exposure
of 30J/cm2 and power density of 250mW/cm2 will be applied. Patients will undergo
clinical evaluations before treatment (day 1) at 30, 60, and 90 days after the end
of treatment; and microbiological evaluations before and immediately after
treatment. The distribution of the data within each group and the homogeneity of
the variances will be verified. With this information, the most appropriate
statistical test in each evaluation will be used. The sample calculation is based
on the literature and the significance level of 5% will be adopted.Discussion:The
combination of PACT with methylene blue in a papain gel and the conventional
treatment may increase the reduction of bacteria in periodontal pockets.
AN - rayyan-563560159
AU - Anselmo, G. G.
AU - Tortamano, A. C. A. C.
AU - Goncalves, M. L. L.
AU - Leal-Rossi, A.
AU - Godoy-Miranda, B. A.
AU - Oliveira, M. R. C.
AU - Oliveira, P. H. C.
AU - Alves, C. B.
AU - Bussadori, S. K.
AU - Prates, R. A.
DO - 10.1097/MD.0000000000018854
IS - 6
KW - NCT03855345
dental curette
dental syringe
methylene blue
papain
adult
antibiotic therapy
article
chemotherapy
chronic disease
clinical article
clinical evaluation
controlled study
echography
human
mouth hygiene
oral biopsy
patient selection
periodontal disease
periodontal pocket
priority journal
tooth brushing
tooth calculus
tooth root
treatment planning
young adult
LA - English
PY - 2020
SN - ["1536-5964", "0025-7974"]
ST - Antimicrobial photodynamic chemotherapy mediated by PapaMBlue on chronic
periodontal disease: Study protocol for a randomized, blind, controlled trial
T2 - Medicine
TI - Antimicrobial photodynamic chemotherapy mediated by PapaMBlue on chronic
VL - 99
ID - 13533
ER -
TY - JOUR
AB - Background: The elimination of the pathogenic microorganisms of the
disease. Methods: Twenty patients with chronic periodontitis will be selected.
Patients will be randomly divided into 2 groups (n = 10). Group 1 will receive
performed at the end of each periodontal treatment session, at sites with bags >= 4
mm. PapaMblue photosensitizer will be deposited in the periodontal pockets with a
syringe and a pre-irradiation time of 1 minute will be adopted. Then, the laser
emitting wavelength of 660 nm, with power of 100 mW, for 2 minutes, radiant
exposure of 30 J/cm(2) and power density of 250 mW/cm(2) will be applied. Patients
will undergo clinical evaluations before treatment (day 1) at 30, 60, and 90 days
after the end of treatment; and microbiological evaluations before and immediately
after treatment. The distribution of the data within each group and the homogeneity
of the variances will be verified. With this information, the most appropriate
on the literature and the significance level of 5% will be adopted. Discussion: The
AN - rayyan-563562173
AU - Anselmo, G. G.
AU - Tortamano, Acac
AU - Goncalves, M. L. L.
AU - Leal-Rossi, A.
AU - Alves, C. B.
AU - Prates, R. A.
DO - 10.1097/MD.0000000000018854
IS - 6
PY - 2020
SN - ["0025-7974", "1536-5964"]
periodontal disease Study protocol for a randomized, blind, controlled trial
T2 - MEDICINE
periodontal disease Study protocol for a randomized, blind, controlled trial
VL - 99
Y2 - 2
ID - 15547
ER -
TY - JOUR
AB - BACKGROUND: The elimination of the pathogenic microorganisms of the
disease. METHODS: Twenty patients with chronic periodontitis will be selected.
Patients will be randomly divided into 2 groups (n = 10). Group 1 will receive
performed at the end of each periodontal treatment session, at sites with bags ≥4
mm. PapaMblue photosensitizer will be deposited in the periodontal pockets with a
syringe and a pre-irradiation time of 1 minute will be adopted. Then, the laser
emitting wavelength of 660 nm, with power of 100 mW, for 2 minutes, radiant exposure
of 30 J/cm and power density of 250 mW/cm will be applied. Patients will undergo
clinical evaluations before treatment (day 1) at 30, 60, and 90 days after the end
of treatment; and microbiological evaluations before and immediately after
treatment. The distribution of the data within each group and the homogeneity of
the variances will be verified. With this information, the most appropriate
on the literature and the significance level of 5% will be adopted. DISCUSSION: The
AN - rayyan-563561234
AU - Anselmo, G. G.
AU - Tortamano, Acac
AU - Gonçalves, M. L. L.
AU - Leal-Rossi, A.
AU - Alves, C. B.
AU - Prates, R. A.
DO - 10.1097/MD.0000000000018854
IS - 6
J2 - Medicine (Baltimore)
KW - Adult
Anti-Infective Agents/administration & dosage/*therapeutic use
Chronic Periodontitis/*therapy
Double-Blind Method
Female
Humans
Male
Methylene Blue/administration & dosage/*therapeutic use
Photochemotherapy
Photosensitizing Agents/administration & dosage/*therapeutic use
Treatment Outcome
LA - eng
N1 - Post Graduation Program in Biophotonics Applied to Health Sciences
Universidade Nove de Julho.; Department of Dentistry, School of Dentistry,
Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.; Post Graduation Program
in Biophotonics Applied to Health Sciences Universidade Nove de Julho.; Department
of Dentistry, School of Dentistry, Universidade Nove de Julho (UNINOVE), São Paulo,
Brazil.; Post Graduation Program in Biophotonics Applied to Health Sciences
in Biophotonics Applied to Health Sciences Universidade Nove de Julho.; Post
Graduation Program in Biophotonics Applied to Health Sciences Universidade Nove de
Julho.; Post Graduation Program in Biophotonics Applied to Health Sciences
Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
PY - 2020
SP - e18854
T2 - Medicine
VL - 99
Y2 - 2
ID - 14608
ER -
TY - JOUR
AB - Gingivitis and lumpy jaw are diseases of polymicrobial aetiology. Although
Fusobacterium necrophorum has been associated with these diseases in macropods,
little is known about other organisms associated with these diseases in this animal
species. PCR-DGGE analysis revealed the potential pathogens associated with
gingivitis and lumpy jaw in macropods. PCR-DGGE profile comparison between the
healthy and disease groups indicated a shift in the oral bacterial community
structures with similarity coefficients of 48% and 35% for gingivitis and lumpy jaw
respectively. Moreover, gingivitis was associated with increase in bacterial
diversity (Shannon index. =2.87; PL curve. =45%) while lumpy jaw resulted in a
decline in bacterial diversity (Shannon index. =2.47; PL curve. =74%). This study
suggest that the establishment of gingivitis and lumpy jaw diseases follows the
ecological plaque hypothesis. This forms the basis for an expanded investigation in
an epidemiological scale and suggests the need for the appropriate choice of
antimicrobial agent(s) and for the effective management and control of
polymicrobial diseases. © 2013 Elsevier Ltd.
AN - rayyan-563560460
AU - Antiabong, J. F.
AU - Boardman, W.
AU - Moore, R. B.
AU - Brown, M. H.
AU - Ball, A. S.
DO - 10.1016/j.rvsc.2013.08.010
IS - 3
KW - RNA 16S
article
bacterium identification
community structure
controlled study
denaturing gradient gel electrophoresis
gingivitis
infection control
jaw disease
lumpy jaw
microbial community
microbial diversity
nonhuman
nucleotide sequence
unindexed sequence
LA - English
PY - 2013
SN - ["0034-5288", "1532-2661"]
SP - 996-1005
ST - The oral microbial community of gingivitis and lumpy jaw in captive macropods
T2 - Res. Vet. Sci.
TI - The oral microbial community of gingivitis and lumpy jaw in captive macropods
VL - 95
ID - 13834
ER -
TY - JOUR
AB - The application of the original Koch postulates and the molecular Koch
postulates in the definition of the etiological agents of polymicrobial diseases
has received little or no attention. In the present study, denaturing gradient gel
electrophoresis (DGGE) of oral samples (n = 3) from each of 3 categories of animals
(healthy, diseased [gingivitis], and then oxytetracycline-treated) was used and
revealed different bacterial community structures in a model polymicrobial disease
(gingivitis) and after clinical cure. Potential microbes associated with the
disease and belonging to the following families were identified: Fusobacteriaceae,
Porphyromonadaceae, Flavobacteriaceae, Alcanivoracaceae, Bacteroidaceae,
Xanthomonadaceae, and Neisseriaceae. Liquid chromatography-mass spectrophotometric
analysis of culturable anaerobic bacteria culture supernatant revealed 3 major
compounds (2-hydroxycaproic acid, phenyllactic acid, and indole acetic acid) that
differentiated the healthy and disease groups. Results indicate that different
microbial community structures were associated with the healthy and disease oral
states. The results demonstrate the potential of DGGE as a tool in the detection
and designation of etiological agents of polymicrobial diseases. © 2013 The
Author(s).
AN - rayyan-563560478
AU - Antiabong, J. F.
AU - Jardine, D.
AU - Boardman, W.
AU - Brown, M. H.
AU - Ball, A. S.
DO - 10.1177/1040638713493628
IS - 4
bacterial DNA
oxytetracycline
RNA 16S
animal
animal disease
article
bacterial infection
bacterium
chemistry
DNA sequence
etiology
genetics
gingivitis
kangaroo
metabolite
microbiology
molecular genetics
molecular Koch postulate
nucleotide sequence
phylogeny
polymicrobial disease
pulsed field gel electrophoresis
sequence alignment
zoo animal
LA - English
PY - 2013
SN - ["1040-6387", "1943-4936"]
SP - 467-472
ST - A molecular ecological approach to the detection and designation of the
etiological agents of a model polymicrobial disease
T2 - J. Vet. Diagn. Invest.
TI - A molecular ecological approach to the detection and designation of the
etiological agents of a model polymicrobial disease
VL - 25
ID - 13852
ER -
TY - JOUR
AB - BACKGROUND: Complete removal of irritants is not possible with mechanical
therapy alone. Adjunctive use of systemic administration of antibiotics results in
the distribution of drug throughout the body, which can give rise to toxicity.
Curcumin (diferuloylmethane), a constituent of Curcuma longa plant, which possess
antioxidant, anti-inflammatory, anti-carcinogenic, anti-microbial, anti-hyper
algesic and hypocholesterolemic properties. The aim of the present study is to
compare the effects of the curcumin gel as an adjunct to subgingival scaling and
root planning with the effect achieved using subgingival scaling and root planning
alone. MATERIALS AND METHODS: Thirty patients either male or female with chronic
localized or generalized periodontitis aged between 25 and 60 years with pocket
depth of 5-7 mm affecting at least two nonadjacent sites were included. In the
experimental site scaling and root planning was performed, followed by placement of
the curcumin gel and periodontal pack application. In the control site, subgingival
scaling alone was performed followed by periodontal pack application. Parameters
included were: Plaque index (PI), gingival index (GI), probing depth (PD) and
clinical attachment loss. These parameters were recorded on day 0, 30 and 45 days.
RESULTS: Significant reduction in mean was observed in PI, GI, PD and gain in
clinical attachment level were demonstrated in both the groups from baseline to 45
days. However, statistical significant reduction was observed in PI at baseline and
30(th) day and GI at 30(th) day. CONCLUSION: Curcumin can be effectively used along
with scaling and root planning. Future research is required to determine the long-
term effects of curcumin on a large sample of subjects.
AN - rayyan-563561333
AU - Anuradha, B. R.
AU - Bai, Y. D.
AU - Sailaja, S.
AU - Sudhakar, J.
AU - Priyanka, M.
AU - Deepika, V.
IS - 7
J2 - J Int Oral Health
LA - eng
N1 - Professor and Head, Department of Periodontics, MNR Dental College &
Hospital, Sangareddy, Medak, Telangana, India.; Professor, Department of
Periodontics, Government Dental College & Hospital, Hyderabad, India.; Associate
Professor, Department of Oral Medicine & Radiology, Government Dental College &
Hospital, Hyderabad, India.; Reader, Department of Periodontics, G. Pullareddy
Dental College & Hospital, Kurnool, Andhra Pradesh, India.; Post Graduate Student,
Department of Periodontics, MNR Dental College & Hospital, Sangareddy, Medak,
Telangana, India.; Post Graduate Student, Department of Periodontics, MNR Dental
College & Hospital, Sangareddy, Medak, Telangana, India.
PY - 2015
SN - 0976-7428 (Print)
SP - 90-3
ST - Evaluation of Anti-Inflammatory Effects of Curcumin Gel as an Adjunct to
Scaling and Root Planing: A Clinical Study
T2 - Journal of international oral health : JIOH
TI - Evaluation of Anti-Inflammatory Effects of Curcumin Gel as an Adjunct to
Scaling and Root Planing: A Clinical Study
VL - 7
Y2 - 7
ID - 14707
ER -
TY - JOUR
AB - Background and Objective: Hydrogen sulfide (H2S) is one of two volatile
sulfur compounds that are known to be the main cause of oral malodor; the other is
methyl mercaptan. Other known volatiles existing in mouth air do not contribute
significantly to oral malodor originating in the oral cavity. Hydrogen sulfide is
also known to be an etiological factor in periodontal disease. However, the effects
of H2S on alveolar bone remain unclear. The objectives of this study were to
determine the apoptotic effects of H2S on osteoblasts and to verify the apoptotic
molecular pathways. Material and Methods: A clonal murine calvaria cell line was
incubated with 50ng/mL of H2S. To detect apoptosis, the cells were analysed by flow
cytometry and ELISA. Mitochondrial membrane depolarization was assessed using flow
cytometry as well. ELISA was used to evaluate the release of cytochromec into the
cytosol and to assess Fas ligand, p53, tumor necrosis factorα, interleukin IL1-α
IL-β, IL-2, IL-4, IL-10, interferon-γ, granulocyte-colony stimulating factor and
granulocyte-macrophage colony stimulating factor. Caspase-3, -8 and -9 activities
were estimated. Expression of BAX and Bcl-2 was assessed by real-time quantitative
RT-PCR. DNA fragmentation was detected by single-cell gel electrophoresis. Fas
receptors were evaluated by western blotting. Results: After H2S incubation,
apoptotic levels increased significantly in a time-dependent manner. Mitochondrial
membrane depolarization, the release of cytochromec, p53 and caspase-3, -8 and -9
and DNA fragmentation were all significantly greater. BAX gene activity was
upregulated, whereas Bcl-2 remained low. Fas ligand/Fas receptor, tumor necrosis
factorα and other cytokines were not increased to a significant degree. Conclusion:
At less-than-pathological concentrations in gingival crevicular fluid, H2S induces
apoptosis in osteoblasts. The molecular mechanisms underlying the apoptotic process
include p53, a mitochondrial pathway and caspase-8 activation. © 2011 John Wiley &
Sons A/S.
AN - rayyan-563560547
AU - Aoyama, I.
AU - Calenic, B.
AU - Imai, T.
AU - Ii, H.
AU - Yaegaki, K.
DO - 10.1111/j.1600-0765.2011.01442.x
IS - 3
KW - caspase 3
caspase 8
caspase 9
cytochrome c
tumor necrosis factor receptor superfamily member 6
Fas ligand
gamma interferon
granulocyte colony stimulating factor
granulocyte macrophage colony stimulating factor
hydrogen sulfide
interleukin 10
interleukin 1alpha
interleukin 1beta
interleukin 2
interleukin 4
protein Bax
protein bcl 2
protein p53
volatile organic compound
animal
apoptosis
article
3T3 cell line
DNA fragmentation
drug effect
halitosis
metabolism
mitochondrial membrane potential
mouse
osteoblast
LA - English
PY - 2012
SN - ["0022-3484", "1600-0765"]
SP - 365-373
ST - Oral malodorous compound causes caspase-8 and -9 mediated programmed cell
death in osteoblasts
T2 - J. Periodontal Res.
TI - Oral malodorous compound causes caspase-8 and -9 mediated programmed cell
death in osteoblasts
VL - 47
ID - 13921
ER -
TY - JOUR
AB - In the present study, we investigated the effects of a Kampo medicine Orento
(TJ-120) on the production of prostaglandin E2 (PGE2), interleukin (IL)-6 and IL-8
by human gingival fibroblasts (HGFs) treated with lipopolysaccharide from
Porphyromonas gingivalis (PgLPS). HGFs proliferation was dose-dependently decreased
with Orento at days 3 and 7. However, treatment with PgLPS (10ng/ml), Orento (up to
1mg/ml) and their combinations for 24h did not affect the viability of HGFs. Orento
suppressed PgLPS-induced PGE2 production in a dose-dependent manner but did not
alter basal PGE2 level. In contrast, Orento did not alter PgLPS-induced IL-6 and
IL-8 productions. These alterations by Orento were similar to those by a mitogen-
activated protein kinase kinase (MAPKK/MEK) inhibitor, PD98059. A Orento showed no
effect on cyclooxygenase (COX)-1 and COX-2 activities, and increased cytoplasmic
phospholipase A2 (cPLA2) expression and increased PgLPS-induced COX-2 expression.
Orento suppressed PgLPS-induced mobility retardation of cPLA2 band on sodium
dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) gels, that is cPLA2
phosphorylation and its activation, while Orento alone did not alter cPLA2
phosphorylation. Orento suppressed PgLPS-induced extracellular signal-regulated
kinase (ERK) phosphorylation, which is known to lead to ERK activation and cPLA2
phosphorylation. These results suggest that Orento decreased PGE2 production by
inhibition of cPLA2 phosphorylation and its activation via inhibition of ERK
phosphorylation, and also that Orento may be useful to improve gingival
inflammation in periodontal disease. © 2010 Pharmaceutical Society of Japan.
AN - rayyan-563560646
AU - Ara, T.
AU - Honjo, K. I.
AU - Fujinami, Y.
AU - Hattori, T.
AU - Imamura, Y.
AU - Wang, P. L.
DO - 10.1248/bpb.33.611
IS - 4
KW - bacterium lipopolysaccharide
cyclooxygenase 1
cyclooxygenase 2
herbaceous agent
interleukin 6
interleukin 8
orento
phospholipase A2
prostaglandin E2
tj 120
unclassified drug
article
cell proliferation
cell viability
Chinese medicine
controlled study
cytokine production
enzyme activation
enzyme activity
enzyme inhibition
enzyme phosphorylation
fibroblast
gingivitis
human
human cell
primary prevention
prostaglandin synthesis
protein expression
LA - English
PY - 2010
SN - ["0918-6158", "1347-5215"]
SP - 611-616
ST - Preventive effects of a kampo medicine, orento on inflammatory responses in
lipopolysaccharide treated human gingival fibroblasts
T2 - Biol. Pharm. Bull.
TI - Preventive effects of a kampo medicine, orento on inflammatory responses in
lipopolysaccharide treated human gingival fibroblasts
VL - 33
ID - 14020
ER -
TY - JOUR
AB - Chitin and its deacetylated derivative chitosan are natural polymers composed
of randomly distributed β-(1-4)-linked D-glucosamine (deacetylated unit) and N-
acetyl-D-glucosamine (acetylated unit). Chitin is insoluble in aqueous media while
chitosan is soluble in acidic conditions due to the free protonable amino groups
present in the D-glucosamine units. Due to their natural origin, both chitin and
chitosan can not be defined as a unique chemical structure but as a family of
polymers which present a high variability in their chemical and physical
properties. This variability is related not only to the origin of the samples but
also to their method of preparation. Chitin and chitosan are used in fields as
different as food, biomedicine and agriculture, among others. The success of chitin
and chitosan in each of these specific applications is directly related to deep
research into their physicochemical properties. In recent years, several reviews
covering different aspects of the applications of chitin and chitosan have been
published. However, these reviews have not taken into account the key role of the
physicochemical properties of chitin and chitosan in their possible applications.
The aim of this review is to highlight the relationship between the physicochemical
properties of the polymers and their behaviour. A functional characterization of
chitin and chitosan regarding some biological properties and some specific
applications (drug delivery, tissue engineering, functional food, food
preservative, biocatalyst immobilization, wastewater treatment, molecular
imprinting and metal nanocomposites) is presented. The molecular mechanism of the
biological properties such as biocompatibility, mucoadhesion, permeation enhancing
effect, anticholesterolemic, and antimicrobial has been updated. © 2009 Bentham
Science Publishers Ltd.
AN - rayyan-563560666
AU - Aranaz, I.
AU - Mengíbar, M.
AU - Harris, R.
AU - Paños, I.
AU - Miralles, B.
AU - Acosta, N.
AU - Galed, G.
AU - Heras, Á
DO - 10.2174/187231309788166415
IS - 2
KW - alginic acid
chitin
chitosan
chymotrypsin A
emulsifying agent
food additive
food preservative
laccase
lysozyme
microsphere
nanocomposite
nanoparticle
penetration enhancing agent
polycaprolactone
adsorption
analgesic activity
anticoagulation
biocatalyst
biocompatibility
biodegradability
biological activity
chemical structure
covalent bond
cross linking
crystallization
deacetylation
depolymerization
diet
drug release
emulsion
encapsulation
enzyme immobilization
erythrocyte aggregation
food preservation
gene delivery system
hydrogel
immobilized cell
Lewis carcinoma
lipid metabolism
molecular weight
mucoadhesion
mucociliary transport
nerve regeneration
nonhuman
periodontal disease
physical chemistry
polymerization
priority journal
review
solid state
solubility
thermosetting hydrogel
tight junction
tissue engineering
viscosity
waste water management
water permeability
wound healing
LA - English
PY - 2009
SN - 1872-3136
SP - 203-230
ST - Functional characterization of chitin and chitosan
T2 - Curr. Chem. Biol.
TI - Functional characterization of chitin and chitosan
VL - 3
ID - 14040
ER -
TY - JOUR
AB - The pineapple (Ananas comosus) is a multiple fruit belonging to the
Bromeliaceae family, has a crude extract Bromelain accumulated in the stem, fruit,
peel and leaves of the pineapple which shows proteolytic activity. The present
study was carried out to assess the accumulation of bromelain in the different
parts of the pineapple. The techniques homogenization with sodium acetate buffer,
followed by filtration and centrifugation were used to extract bromelain from
pineapple. The crude bromelain was then purified by ammonium sulphate salt
precipitation, dialysis and finally subjected to ion exchange chromatography.
Lowry's method and gelatine digestion unit (GDU) analytical method were performed
to estimate the concentration and activity of the crude enzyme and purified
bromelain from the different parts The molecular weight of the purified enzyme was
determined by SDS-PAGE (sodium dodecyl sulphate - polyacrylamide gel
electrophoresis) analysis and found to be 25 to 27 KDa. The final step was to find
out the effect of bromelain from leaves and stem of pineapple on pathogens of
periodontitis. The enzyme exhibited proteolytic activity against certain bacteria
and its capacity to enhance the activity of antibiotics on pathogens causing
periodontal diseases. The results of the study confirmed that the enzyme has a high
commercial value and a wide range of applications in the field of medicine and
biotechnology.
AN - rayyan-563560404
AU - Aravind, K. V.
AU - Gokulakrishnan, M.
DO - 10.13040/IJPSR.0975-8232.6(12).5284-94
IS - 12
KW - amoxicillin
ampicillin
bromelain
chlorhexidine
ciprofloxacin
article
bacterial growth
controlled study
drug determination
drug isolation
drug potentiation
drug purification
enzyme activity
growth inhibition
molecular weight
nonhuman
periodontitis
pineapple
plant leaf
plant stem
Serratia marcescens
LA - English
PY - 2015
SN - ["0975-8232", "2320-5148"]
SP - 5284-5294
ST - Extraction, purification of bromelain from pineapple and determination of its
effect on bacteria causing periodontitis
TI - Extraction, purification of bromelain from pineapple and determination of its
effect on bacteria causing periodontitis
VL - 6
ID - 13778
ER -
TY - JOUR
AB - OBJECTIVES: To evaluate the adjunctive effect of a thermosensitive gel
formulation that contains 0.8% oligo hyaluronic acid (HA) combined with a
preservation system of octenidine HCl 0.625% and phenoxyethanol to scaling and root
planing (SRP) as compared with SRP alone in the treatment of residual pockets of
patients with stage 3 periodontitis. MATERIALS AND METHODS: Thirty-four patients
(21 males and 13 females) aged 29-78 years (51.3 ± 13.1) with stage 3 periodontitis
were recruited to participate in the present split-mouth study. None of the
patients has been previously treated for periodontitis. Plaque index (PI), probing
depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were
evaluated at baseline and at 3 and 6 months post treatment. Full-mouth SRP was
performed in all residual pockets ≥ 5 mm. Treatment was performed by means of
ultrasonic and hand instruments and lasted 45-60 min. The gel was applied
subgingivally in the test sites immediately after SRP (baseline) and 1 month later.
The paired t-test for two means was applied to test the statistical significance of
the change from baseline within each arm and determine the difference between
groups. The level of significance was set at 0.05 for all tests. RESULTS: Mean PD
reductions between baseline and 3 and 6 months were 1.98 mm and 2.79 mm for the
test and 1.22 mm and 1.50 mm for the control group, respectively. Comparisons
between the test and control groups revealed that SRP + gel yielded statistically
significantly higher PD reductions compared to SRP alone (p < 0.0001). Compared to
baseline, CAL and BOP values improved statistically significantly in both groups,
although the test group presented statistically significantly higher CAL gains and
BOP reductions than the control group (P < 0.0001). CONCLUSION: In residual pockets
of stage 3 periodontitis patients, the local application of a thermosensitive gel
with an active HA ingredient and a preservation system of octenidine HCl 0.625% in
conjunction with SRP may additionally improve the clinical outcomes obtained with
SRP alone. CLINICAL RELEVANCE: A novel HA and octenidine containing thermosensitive
gel effectively improved the clinical parameters in stage 3 periodontitis patients
over a 6-month period.
AN - rayyan-563559872
AU - Ariel, H.
AU - Kahn, A.
AU - Hila, Z. O.
AU - Anton, S.
AU - Natan, G.
AU - Kolerman, R.
DO - 10.1007/s00784-021-04344-2
IS - 4
KW - hyaluronic acid
imine
octenidine
pyridine derivative
adult
aged
controlled study
dental scaling
female
human
male
middle aged
prospective study
root planing
LA - English
PY - 2022
SN - 1436-3771
SP - 3721-3733
ST - A thermosensitive gel with an active hyaluronic acid ingredient that contains
an octenidine preservation system as an adjunct to scaling and root planning: a
randomized prospective clinical study
TI - A thermosensitive gel with an active hyaluronic acid ingredient that contains
an octenidine preservation system as an adjunct to scaling and root planning: a
VL - 26
ID - 13246
ER -
TY - JOUR
AB - Objectives: The objectives of this study were to develop alginate based
metronidazole periodontal gel for local microbes eradication in periodontal pocket,
to study the effect of 0.5 and 1% Carbopol addition to alginate base on drug
release and antibacterial activity of the gel, and to identify the effect of
storage at room temperature for 3 months on chemical and physical stability of the
gel. Methods: The 25% metronidazole periodontal gel was prepared using alginate gel
alone and in combination with 0.5 and 1% Carbopol. All of prepared formulations
were evaluated for the pH, drug release, and antibacterial susceptibility.
Stability of formulations were studied for 3 months including drug content, color
and viscosity. Results: The release of metronidazole from alginate gel showed
sustained release properties. Within 300 minutes study, metronidazole released from
formulations without Carbopol, with 0.5%, and 1% Carbopol were 40.17%, 47.67%, and
51.48%, respectively. Addition of 0.5 and 1% Carbopol did not significantly affect
the drug release. All formulations showed excellent inhibition to Staphylococcus
aureus. The largest zone of inhibition was found on formula without Carbopol, then
followed by formula with 1% and 0.5% Carbopol. Storage at room temperature for 3
months caused slight degradation of metronidazole content and viscosity of all
formulations. However, the color was not affected. Conclusions: It is concluded
that metronidazole periodontal gel can be formulated using alginate base. The
alginate based metronidazole periodontal gel has sustained release properties. All
formulations have excellent antibacterial activity, and stable on storage at room
temperature for 3 months.
AN - rayyan-563560433
AU - Ariyana
AU - Sinurat, D.
AU - Ervina, I.
AU - Hakim Bangun, D.
IS - 1
KW - alginic acid
calcium chloride
carbomer
glycerol
metronidazole
water
article
color
drug degradation
drug formulation
drug release
drug stability
gel
in vitro study
nonhuman
periodontal gel
pH
room temperature
storage temperature
viscosity
LA - English
PY - 2014
SN - 0974-2441
SP - 223-227
ST - Formulation and in vitro evaluation of alginate based metronidazole
periodontal gel
TI - Formulation and in vitro evaluation of alginate based metronidazole
periodontal gel
VL - 7
ID - 13807
ER -
TY - JOUR
AB - We have previously reported that sodium 5,6-benzylidene-L-ascorbate (SBA)
induced dramatic antitumor activity in inoperable cancer patients, but induced only
marginal tumor specificity in vitro. Here the tumor specificity and type of cell
death induced by benzaldehyde (BA), a degradation product of SBA, was investigated,
using human tumor cell lines (oral squamous cell carcinoma [OSCC], glioblastoma,
myelogenous leukemia) and human normal oral cells (gingival fibroblast, pulp cell,
periodontal ligament fibroblast). BA showed much higher tumor-specific cytotoxicity
than SBA. BA induced the formation of autophagosomes, the destruction of
mitochondrial structure and digestion of broken organelles, without any apparent
induction of internucleosomal DNA fragmentation and caspase activation in an OSCC
cell line HSC-2, in a similar manner to SBA. However, pretreatment with 3-
methyladenine or bafilomycin A 1, autophagy inhibitors, did not completely rescue
the cells from the cytotoxicity induced by BA. The study suggests that BA may play
an important role in the induction of antitumor activity of SBA in vivo, although
the autophagic phenotypes induced by BA may be involved in both cell death and
survival.
AN - rayyan-563560616
AU - Ariyoshi-Kishino, K.
AU - Hashimoto, K.
AU - Amano, O.
AU - Saitoh, J.
AU - Kochi, M.
AU - Sakagami, H.
IS - 12
KW - 3 methyladenine
zilascorb
bafilomycin A1
benzaldehyde
caspase 3
caspase 8
dactinomycin
agar gel electrophoresis
article
autophagy
cancer cell culture
cancer cell destruction
cell death
cell structure
cell survival
cell viability
controlled study
cytotoxicity
DNA fragmentation
enzyme activation
enzyme activity
fibroblast
glioblastoma
human
human cell
mouth carcinoma
myeloid leukemia
phagosome
phenotype
priority journal
LA - English
PY - 2010
SN - 0250-7005
SP - 5069-5076
ST - Tumor-specific cytotoxicity and type of cell death induced by benzaldehyde
T2 - Anticancer Res.
TI - Tumor-specific cytotoxicity and type of cell death induced by benzaldehyde
VL - 30
ID - 13990
ER -
TY - JOUR
AB - Objective: The aim was to evaluate the efficacy of periodontal regenerative
therapy using enamel matrix derivatives (EMDs) in aggressive periodontitis
patients, and to determine the con tribution of maintenance via periodic supportive
periodontal treatment. Method and materials: In total, 28 patients were evaluated,
comprising 74 intrabony sites. In 50 sites EMD gel was applied, and in 24 sites EMD
was combined with depro teinized bovine xenograft. Patients were assigned to a sup
portive periodontal treatment program; 18 patients fulfilled the program, defined
as the well-maintained (WM) group; 10 did not comply, defined as the nonmaintained
(NM) group. Probing depth (PD), clinical attachment level (CAL), and radio graphic
bone level (BL) were recorded. Data were compared presurgically (T0), 6 months
postsurgery (T1), and 3 to 10 years posttreatment (T2). Results: Both surgical
modalities achieved similar PD reduction, CAL gain, and BL gain, maintained over
time. T1 to T2 showed a mean gain/loss of 0.21 ± 0.5 mm and 0.04 ± 1.1 mm, and
−0.65 ± 3.0 mm and −0.73 ± 3.0 mm for PD and CAL, respectively, at the WM/NM
groups, respectively. BL gain was 21.6% and 11.5% for the WM/NM groups, respect
ively (P <.05). The courses of the PD, CAL, and BL differed be tween the WM and NM
groups during the observation periods (P <.05). Conclusion: Periodontal
regeneration via EMD with/ without the combination of deproteinized bovine
xenograft can be maintained in aggressive periodontitis cases. It appears that
periodic supportive periodontal treatment is a determi nant factor in achieving
this task.
AN - rayyan-563559996
AU - Artzi, Z.
AU - Sudri, S.
DO - 10.3290/j.qi.b912657
IS - 5
KW - suture
Vicryl Ethicon
amoxicillin
dental material
enamel matrix derivative
metronidazole
unclassified drug
adult
antibiotic therapy
article
clinical article
clinical outcome
controlled study
dental surgery
female
human
male
medical parameters
periodontal guided tissue regeneration
probing depth
systemic therapy
tooth radiography
LA - English
PY - 2021
SN - ["1936-7163", "0033-6572"]
SP - 402-410
ST - The impact of supportive periodontal treatment on the outcome of regenerative
surgical therapy in aggressive periodontitis patients
T2 - Quintessence Int.
TI - The impact of supportive periodontal treatment on the outcome of regenerative
surgical therapy in aggressive periodontitis patients
VL - 52
ID - 13370
ER -
TY - JOUR
AB - Background: The pathogenesis of the periodontal disease is primarily due to
the gram-negative bacteria found in the plaque. Adjunctive to the routine
mechanical debridement, use of systemic and local antimicrobials for reduction and
eradication of specific periodontal pathogens have also been used for quite some
time. Various locally delivered therapeutic drugs have been used. The success of
the locally delivered therapeutic drugs are determined by the usage of vehicles.
Aim: The purpose of this study was to evaluate the efficacy of carboxy methyl
cellulose gel as a vehicle for metronidazole when compared to commercially
available Metrogyl® DG gel in an in vitro condition. Methods: 20 patients with
chronic periodontitis were selected and subgingival plaque samples were collected
using curettes and then subjected to anaerobic culture. The samples were inoculated
on Brucella Blood Agar (BBA) plates by streaking the plate with the swab sticks
within 12 hours from sample collection. A well with a diameter of 8 mm is punched
and 100 μm of the 1.5% metronidazole with the 2 different vehicles ((methyl
cellulose gel, Metrogyl® DG gel) were introduced into the wells. These plates were
kept in an an anaerobic jar along with an aero gas pack and incubated at 37°C for
48 hours to 72 hours. The antimicrobial activity was quantitatively assessed by the
presence or absence of inhibition zone and zone diameter. Result: It was found that
anaerobic bacteria found in subgingival plaque, showed sensitivity to the drug
released from both the vehicles. The inhibition zone diameter present around
methylcellolose gel + metronidazole was 23.85±1.73 mm and that around Metrogyl® was
14.4±1.76 mm. Conclusion: Methylcellulose gel is a more effective vehicle than
commercially available vehicles in releasing metronidazole for use in subgingival
delivery in the management of chronic periodontitis.
AN - rayyan-563560170
AU - Arunachalam, D.
AU - Varghese, S. S.
DO - 10.5958/0976-5506.2019.04152.4
IS - 11
KW - agar
carboxy methyl cellulose gel
gel
methylcellulose
metronidazole
unclassified drug
anaerobic bacterium
article
bacterial strain
clinical article
comparative study
controlled study
human
in vitro study
nonhuman
pathogenesis
zone of inhibition
flagyl
metrogyl
LA - English
PY - 2019
SN - ["0976-5506", "0976-0245"]
SP - 3635-3638
ST - Evaluation of methylcellulose gel as a vehicle for metronidazole compared to
commercially available topical metronidazole gel-an in vitro study
T2 - Indian J. Public Health Res. Dev.
TI - Evaluation of methylcellulose gel as a vehicle for metronidazole compared to
commercially available topical metronidazole gel-an in vitro study
VL - 10
ID - 13544
ER -
TY - JOUR
AB - BACKGROUND: Chlorhexidine (CHX) is a broad-spectrum antimicrobial agent
commonly used in medicine. Application of (CHX) during abutment connection reduced
the bacterial load at the implant-abutment interface. We hypothesize this treatment
may consequently reduce peri-implant soft tissue inflammation and marginal bone
loss. PURPOSE: To evaluate the effect of a single application of CHX gel inside the
dental implant internal hexagon on peri-implant tissue. METHODS: Forty patients
were recruited to this randomized, double-blinded, clinical trial. At the time of
implant installation, a 4-mm healing abutment was connected to the implant. In the
test group, chlorhexidine gel 1% was applied inside the implant hex, whereas
control implants did not receive any gel. Clinical and radiographic measurements
included soft tissue recession (REC), plaque index (PI), gingival index (GI),
plaque index (PI), keratinized mucosa width (KM), probing depth (PD), and a peri-
apical parallel x-ray. Peri-implant crevicular fluid (PICF) was collected for
cytokine analysis. t-Test was used to compare changes from baseline to 3 months.
Mann-Whitney U test and t test were used to compare test and control groups.
RESULTS: Twenty patients in the test group and 17 in the control group completed
the study. One implant in the control group failed to osteointegrate. There were no
significant differences between the control and test groups for REC changes, bone
loss, and PD. GI was significantly lower in the test group after 1 week (1.79 ±
0.24 vs 0.75 ± 0.18, respectively) and 3 months (1.18 ± 0.21 vs 0.25 ± 0.12,
respectively) although PI was equal. At 3 months, interleukin 1-β (IL1-β) was
higher in the control group (p < 0.01) and a positive correlation was found between
GI and IL1-β (rs = 0.60424, p = 0.00032). CONCLUSIONS: Application of chlorhexidine
gel reduced inflammation and IL1-β levels in the peri-implant soft tissue.
AN - rayyan-563559959
AU - Asbi, T.
AU - Hussein, H. A.
AU - Horwitz, J.
AU - Gabay, E.
AU - Machtei, E. E.
AU - Giladi, H. Z.
DO - 10.1111/cid.13041
IS - 5
KW - chlorhexidine
interleukin 1
controlled study
gingivitis
human
inflammation
plaque index
tooth implant
LA - English
PY - 2021
SN - 1708-8208
SP - 726-734
ST - A single application of chlorhexidine gel reduces gingival inflammation and
interleukin 1-β following one-stage implant placement: A randomized controlled
study
T2 - Clin Implant Dent Relat Res
TI - A single application of chlorhexidine gel reduces gingival inflammation and
interleukin 1-β following one-stage implant placement: A randomized controlled
study
VL - 23
ID - 13333
ER -
TY - JOUR
AB - BACKGROUND: Periodontitis is inflammation of the supporting tissues of the
teeth caused by specific microorganisms. Intra-periodontal pocket, mucoadhesive
drug delivery systems have been shown to be clinically effective in the treatment
of periodontitis. The aim of this study was to formulate a mucoadhesive gel from
the seed hull of Quercus brantii and fruits of Coriandrum sativum for the treatment
of periodontitis. MATERIALS AND METHODS: The semisolid concentrated extracts were
incorporated in gel base. Mucoadhesive gels were prepared using carbopol 940,
sodium carboxymethylcellulose (sodium CMC) and hydroxypropyl methylcellulose K4M
(HPMC) as bioadhesive polymers. Physicochemical tests, mucoadhesive strength
measurement and in vitro drug release study were carried out on two formulations
containing carbopol 940 and sodium CMC polymers (Formulations F4 and F5). We
investigated the antibacterial activity of formulation F5 against Porphyromonas
gingivalis using the disk diffusion method on supplemented Brucella agar. RESULTS:
Eight gel formulations were prepared. Physical appearance, homogeneity and
consistency of F4 and F5 were good. Mucoadhesion and viscosity of F5 (1% carbopol
940 and 3% sodium CMC) was more than F4 (0.5% carbopol 940 and 3% sodium CMC). Drug
release from F5 was slower. Both of formulations were syringeable through 21 G
needle. In the disk diffusion method, F5 produced significant growth inhibition
zones against P. gingivalis. CONCLUSION: The ideal formulation for the treatment of
periodontitis should exhibit high value of mucoadhesion, show controlled release of
drug and be easily delivered into the periodontal pocket preferably using a
syringe. Based on in vitro release and mucoadhesion studies, F5 was selected as the
best formulation.
AN - rayyan-563561110
AU - Aslani, A.
AU - Ghannadi, A.
AU - Najafi, H.
DO - 10.4103/2277-9175.108007
J2 - Adv Biomed Res
LA - eng
N1 - Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery
Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
PY - 2013
SN - 2277-9175 (Print)
SP - 21
ST - Design, formulation and evaluation of a mucoadhesive gel from Quercus brantii
L. and coriandrum sativum L. as periodontal drug delivery
T2 - Advanced biomedical research
TI - Design, formulation and evaluation of a mucoadhesive gel from Quercus brantii
L. and coriandrum sativum L. as periodontal drug delivery
VL - 2
ID - 14484
ER -
TY - JOUR
AB - BACKGROUND: Periodontitis is a disease of tooth supporting tissues, and Gram-
negative Bacteria are the main cause of this. Propolis has antibacterial, anti-
inflammatory, and antioxidant effects due to its high polyphenol and flavonoids
content. The aim of this study is the formulation of a mucoadhesive gel containing
concentrated extract of propolis for treatment of periodontitis. MATERIALS AND
METHODS: Formulations containing carbopol 940, sodium carboxymethylcellulose
(NaCMC), hydroxypropyl methylcellulose K4M, and propolis extract were prepared.
Among ten prepared formulations, five formulations had acceptable and proper
physical appearance and uniformity; thus, they were selected for physicochemical
tests (centrifugal, thermal change, cooling and heating, freeze and thaw, thermal
stress, and pH evaluation), quantification of flavonoids, viscosity, mucoadhesion,
drug release, and syringeability tests. We investigated the antibacterial activity
of F(10) (carbopol 940 1%, NaCMC 3%) against Porphyromonas gingivalis using the
disk diffusion method. RESULTS: Phenolic content was measured 39.02 ± 3.24 mg/g of
concentrated extract as gallic acid and flavonoid content was determined 743.28 ±
12.1 mg/g of concentrated extract as quercetin. Highest viscosity (3700 cps) and
mucoadhesion (21 MPa) were seen in F(10). Study of release profile in F(10) also
revealed that propolis could release from this system in more than 7 days. All of
the five selected formulations had ease of syringeability in 21-gauge needle for
drug delivery into periodontal pocket. In the disk diffusion method, F(10) produced
significant growth inhibition zones against P. gingivalis. CONCLUSION: Controlled
release of drug into periodontal pocket helps effective treatment and recovery,
higher persistence and reduces drug use frequency. Increase of carbopol 940 leads
to viscosity and mucoadhesion elevation and accordingly decreases of release rate.
F(10) was the best formulation because of highest viscosity and mucoadhesion and
lowest release rate. It had efficient function in treatment of periodontitis, so we
recommend it for clinical evaluation.
AN - rayyan-563560813
AU - Aslani, A.
AU - Malekpour, N.
DO - 10.4103/1735-3327.197037
IS - 6
J2 - Dent Res J (Isfahan)
LA - eng
N1 - Department of Pharmaceutics, School of Pharmacy, Novel Drug Delivery Systems
Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.; Department
of Pharmaceutics, School of Pharmacy, Novel Drug Delivery Systems Research Center,
Isfahan University of Medical Sciences, Isfahan, Iran.
PY - 2016
SN - 1735-3327 (Print)
SP - 484-493
ST - Design, formulation, and physicochemical evaluation of periodontal propolis
mucoadhesive gel
T2 - Dental research journal
TI - Design, formulation, and physicochemical evaluation of periodontal propolis
mucoadhesive gel
VL - 13
Y2 - 11
ID - 14187
ER -
TY - JOUR
AB - Background: Medicinal use of a plant's seeds, berries, roots, leaves, bark,
or flowers is knownas herbal medicine, botanical medicine, or phytomedicine. The
usage of herbs goes beyond the realm of traditional medicine, but this practice has
a long history. Almost one fourth of pharmaceutical drugs are derived from
botanicals. One such product is peach scientifically calledas "Prunus persica".
Aims: to evaluate the astringent and anti-inflammatory property of Prunus Persica
in comparisonto chlorhexidine gel. Settings and design: Randomized, Parallel Group
Trial Material and methods: The present research is a randomized control trial
using mouth wash prepared from peach extract for a period of 28 days. The
participants were given a random assignment to either the positive control group or
the test group. A modified version of the Quigley and Hein (1962) index developed
by Turesky (1970) was used to provide a score to the amount of plaque. Following
that, gingival inflammation was evaluated with the use of the Gingival Index.
Descriptive and inferential statistics were performed using SPSS, Post hoc ANOVA,
paired t and unpaired t test was used. Results: When mean scores of gingival
indices were compared for group 1 at baseline vs 14days, baseline vs 28 days, it
was found to be statistically significant. In case of Quigley, the plaque index
significant difference was found only at baseline vs 28 days in both groups.
Conclusion: These studies revealed the anti-inflammatory effect of Prunus Persica
by analyzing gingival condition before and after intervention. Statistically
significant (<0.05) difference was seen by its regular usage. Prunus Persica has
anti-allergic inflammatory properties via controlling calcium influx and NF-kB
signaling.
AN - rayyan-563559808
AU - Assiry, A. A.
AU - Tasleem, R.
AU - Alhaid, A.
AU - Almuaddi, A.
AU - Patil, A. R.
AU - Bhavikatti, A.
AU - Javeed, M. Md
AU - Bhavikatti, S. K.
IS - 8
KW - antiinflammatory agent
astringent agent
chlorhexidine
mouthwash
adult
article
clinical article
controlled study
drug efficacy
female
gingivitis
human
male
parallel design
plaque index
Prunus
Prunus pursica
tooth plaque
young adult
LA - English
PY - 2022
SN - 2515-8260
SP - 1713-1724
ST - Efficacy of Prunus Pursica on Plaque Accumulation and GingivalInflammation: A
Double-Blind Clinical Trial
T2 - Eur. J. Mol. Clin. Med.
TI - Efficacy of Prunus Pursica on Plaque Accumulation and GingivalInflammation: A
Double-Blind Clinical Trial
VL - 9
ID - 13182
ER -
TY - JOUR
AB - Regenerative medicine, and dentistry offers enormous potential for enhancing
treatment results and has been fueled by bioengineering breakthroughs over the
previous few decades. Bioengineered tissues and constructing functional structures
capable of healing, maintaining, and regenerating damaged tissues and organs have
had a broad influence on medicine and dentistry. Approaches for combining
bioinspired materials, cells, and therapeutic chemicals are critical in stimulating
tissue regeneration or as medicinal systems. Because of its capacity to maintain an
unique 3D form, offer physical stability for the cells in produced tissues, and
replicate the native tissues, hydrogels have been utilized as one of the most
frequent tissue engineering scaffolds during the last twenty years. Hydrogels’ high
water content can provide an excellent conditions for cell viability as well as an
architecture that mimics real tissues, bone, and cartilage. Hydrogels have been
used to enable cell immobilization and growth factor application. This paper
summarizes the features, structure, synthesis and production methods, uses, new
challenges, and future prospects of bioactive polymeric hydrogels in dental and
osseous tissue engineering of clinical, exploring, systematical and scientific
applications.
AN - rayyan-563559718
AU - Atia, G. A. N.
AU - Shalaby, H. K.
AU - Ali, N. G.
AU - Morsy, S. M.
AU - Ghobashy, M. M.
AU - Attia, H. A. N.
AU - Barai, P.
AU - Nady, N.
AU - Kodous, A. S.
AU - Barai, H. R.
DO - 10.3390/ph16050702
IS - 5
KW - tissue scaffold
albumin
alginic acid
carrageenan
cellulose
collagen
copolymer
cyclodextrin
dextran
fibrinogen
gelatin
gum
hyaluronic acid
hydrogel
ionic crosslinked hydrogel
macrogol
microbead
nanogel
natural polymer
pluronic block copolymer
poly (n isopropyl acrylamide)
poly(a hydroxy esters)
polyglactin
polylactic acid
polymer
polymeric framework
polysaccharide
silk fibroin
starch
unclassified drug
xyloglucan
bone regeneration
bone tissue
cartilage repair
cementum regeneration
chemical structure
craniofacial tissue engineering
cross linking
cytotoxicity
degradation
dentin complex regeneration
gelation
gingival tissue regeneration
human
hydrogen bond
nonhuman
oral tissue engineering
orthopedic surgery
periodontal regeneration
pulp complex regeneration
review
synthesis
thermoregulation
tissue engineering
tissue regeneration
tooth tissue
LA - English
PY - 2023
SN - 1424-8247
ST - New Challenges and Prospective Applications of Three-Dimensional Bioactive
Polymeric Hydrogels in Oral and Craniofacial Tissue Engineering: A Narrative Review
TI - New Challenges and Prospective Applications of Three-Dimensional Bioactive
Polymeric Hydrogels in Oral and Craniofacial Tissue Engineering: A Narrative Review
VL - 16
ID - 13092
ER -
TY - JOUR
AB - Dental tissue infections have been affecting millions of patients globally
leading to pain, severe tissue damage, or even tooth loss. Commercial sterilizers
may not be adequate to prevent frequent dental infections. Antimicrobial hydrogels
have been introduced as an effective therapeutic strategy for endodontics and
periodontics since they have the capability of imitating the native extracellular
matrix of soft tissues. Hydrogel networks are considered excellent drug delivery
platforms due to their high-water retention capacity. In this regard, drugs or
nanoparticles can be incorporated into the hydrogels to endow antimicrobial
properties as well as to improve their regenerative potential, once
biocompatibility criteria are met avoiding high dosages. Herein, novel
antimicrobial hydrogel formulations were discussed for the first time in the scope
of endodontics and periodontics. Such hydrogels seem outstanding candidates
especially when designed not only as simple volume fillers but also as smart
biomaterials with condition-specific adaptability within the dynamic
microenvironment of the defect site. Multifunctional hydrogels play a pivotal role
against infections, inflammation, oxidative stress, etc. along the way of dental
regeneration. Modern techniques (e.g., 3D and 4D-printing) hold promise to develop
the next generation of antimicrobial hydrogels together with their limitations such
as infeasibility of implantation.
AN - rayyan-563559683
AU - Atila, D.
AU - Kumaravel, V.
DO - 10.1039/d3bm00719g
KW - adult
biocompatibility
drug megadose
drug therapy
endodontics
human
infectious inflammation
microenvironment
oxidative stress
pain
periodontal disease
periodontics
prevention
printing
regeneration
review
soft tissue
sterilizer
surgery
tissue engineering
tissue injury
tooth infection
tooth tissue
water retention
antiinfective agent
hydrogel
nanoparticle
LA - English
PY - 2023
SN - 2047-4849
ST - Advances in antimicrobial hydrogels for dental tissue engineering:
regenerative strategies for endodontics and periodontics
T2 - Biomater Sci
TI - Advances in antimicrobial hydrogels for dental tissue engineering:
regenerative strategies for endodontics and periodontics
ID - 13057
ER -
TY - JOUR
AB - Atila-Pektas, B, Yurdakul P, Gulmez D, Go"rduysus O. Antimicrobial effects of
root canal medicaments against Enterococcus faecalis and Streptococcus mutans.
International Endodontic Journal, 46, 413-418, 2013. Aim To compare the
antimicrobial activities of Activ Point (Roeko, Langenau, Germany), Calcium
Hydroxide Plus Point (Roeko, Langenau, Germany), calcium hydroxide, 1%
chlorhexidine gel and bioactive glass (S53P4) against Enterococcus faecalis and
Streptococcus mutans. Methodology One hundred and twenty extracted single-rooted
human teeth were used. After removing the crowns, root canals were prepared by
using the Protaper rotary system. Following autoclave sterilization, root canals
were incubated at 37 degrees C with E.faecalis ATCC 29212 and S.mutans RSHM 676 for
1week. The specimens, which were divided into five treatment groups for each
microorganism according to the intracanal medicament used, were tested in 10
experimental runs. In each experimental run, 10 roots were included as treatment,
one root as positive control and one root as sterility control. Sterile paper
points were utilized to take samples from root canals after the incubation of teeth
in thioglycollate medium at 37 degrees C for 1week. Samples taken from teeth by
sterile paper points were inoculated onto sheep blood agar, and following an
overnight incubation, the colonies grown on sheep blood agar were counted and
interpreted as colony-forming units. Results were tested statistically by using
KruskalWallis and Conover's nonparametric multiple comparison tests. Results CHX
gel (P<0.001 and P<0.001), Activ Point (P=0.003 and P=0.002) and Ca(OH)2 (P=0.010
and P=0.005) were significantly more effective against E.faecalis than that of
Ca(OH)2 Plus Point and bioactive glass, respectively. On the other hand, compared
with Ca(OH)2, CHX gel (P<0.001), and Activ Point (P<0.001), bioactive glass
(P=0.014) produced significantly lower colony counts of S.mutans. When compared
with the positive control, treatment with Ca(OH)2 Plus Point (P=0.085 and P=0.066)
did not produce significantly lower colony counts of E.faecalis and S.mutans,
respectively. Conclusions Compared with the medicaments having an antimicrobial
effect because of their alkaline pH, the medicaments containing chlorhexidine were
effective against both E.faecalis and S.mutans.
AN - rayyan-563562453
AU - Atila-Pektas, B.
AU - Yurdakul, P.
AU - Gulmez, D.
AU - Gorduysus, O.
DO - 10.1111/iej.12004
IS - 5
PY - 2013
SN - 0143-2885
SP - 413-418
ST - Antimicrobial effects of root canal medicaments against Enterococcus faecalis
and Streptococcus mutans
T2 - INTERNATIONAL ENDODONTIC JOURNAL
TI - Antimicrobial effects of root canal medicaments against Enterococcus faecalis
and Streptococcus mutans
VL - 46
Y2 - 5
ID - 15827
ER -
TY - JOUR
AB - OBJECTIVE: Control of subgingival plaque is of paramount importance in the
treatment of periodontal diseases. The role of subgingival sustained-release
antibiotic therapy needs elucidation. A single-blind clinical trial was carried out
in 13 patients with adult periodontitis to compare the effects of subgingival
application of metronidazole dental gel with those of subgingival scaling. METHOD
AND MATERIALS: A split-mouth design was used so that each patient received all
treatments simultaneously. Randomly selected quadrants were treated with
application of 25% metronidazole gel, subgingival scaling, or a combination of
scaling and gel application. The remaining quadrant in each patient was left
untreated as a control. RESULTS: All three treatments were effective in
significantly reducing Plaque Index, Gingival Index, and bleeding on probing over
the 14-week observation period. No statistically significant differences were found
between scaling alone and combined treatment. Scaling and combined treatment were
better than metronidazole. Metronidazole produced transient effects, best noted
during the first 4 weeks after treatment. No additive effect of metronidazole was
noted in the combined treatment. At week 14, only combined treatment sites and
scaled sites showed statistically greater probing depth reduction than control
sites. CONCLUSION: For the treatment of mild-to-moderate adult periodontitis,
subgingival scaling alone is as effective as the combination of scaling and
antibiotic therapy.
AN - rayyan-563561033
AU - Awartani, F. A.
AU - Zulqarnain, B. J.
IS - 1
antitrichomonal agent
metronidazole
adult
clinical trial
comparative study
controlled study
gel
human
male
middle aged
periodontics
periodontitis
review
tooth plaque
LA - English
PY - 1998
SN - 0033-6572
SP - 41-48
ST - Comparison of the clinical effects of subgingival application of
metronidazole 25% gel and scaling in the treatment of adult periodontitis
T2 - Quintessence Int
TI - Comparison of the clinical effects of subgingival application of
metronidazole 25% gel and scaling in the treatment of adult periodontitis
VL - 29
ID - 14407
ER -
TY - JOUR
AN - rayyan-563562151
AU - Axelsson, P.
IS - 5
PY - 1993
SP - 473-482
ST - Current role of pharmaceuticals in prevention of caries and periodontal
disease
T2 - International dental journal
TI - Current role of pharmaceuticals in prevention of caries and periodontal
disease
0027680333&partnerID=40&md5=79c51a3344165b57db12d6e2f4c1592c
VL - 43
ID - 15525
ER -
TY - JOUR
AN - rayyan-563561579
AU - Ayala-Ham, A.
AU - López-Gutierrez, J.
AU - Bermúdez, M.
AU - Aguilar-Medina, M.
AU - Sarmiento-Sánchez, J. I.
AU - López-Camarillo, C.
AU - Sanchez-Schmitz, G.
AU - Ramos-Payan, R.
DO - 10.3389/fmats.2021.708945
PY - 2021
ST - Hydrogel-Based Scaffolds in Oral Tissue Engineering
T2 - Frontiers in Materials
TI - Hydrogel-Based Scaffolds in Oral Tissue Engineering
85112377088&doi=10.3389%2ffmats.2021.708945&partnerID=40&md5=2de461c27c1a5cbf85db3f
38e521ed85
VL - 8
ID - 14953
ER -
TY - JOUR
AB - Background: Recent studies reported that hyaluronic acid (HA) has anti-
inflammatory, anti-edematous, and anti-bacterial activities in dentistry,
particularly in gingival disorders caused by subgingival plaque microorganisms.
Aims: This study aimed to evaluate the early term effects of HA as an adjunct to
scaling and root planing (SRP) on clinical parameters, periodontal inflamed surface
area (PISA), and adenosine deaminase (ADA), catalase (CAT), and glutathione (GSH)
levels in gingival crevicular fluid (GCF) in periodontitis. Methods: A total of 24
periodontitis patients per group were included in this randomized-controlled study.
The study population was divided into four groups: in Group 1: SRP+ saline; in
Group 2: SRP + HA gel; in Group 3: SRP+ HA mouth rinse; and in Group 4: SRP + HA
mouth rinse + HA gingival gel were applied. At baseline and week 4, clinical
parameters and PISA were calculated. Also, biochemicals’ (ADA, CAT, and GSH) levels
were determined by spectrophotometric analysis. Results: There was a statistically
significant improvement in clinical parameters and PISA in all four groups in
control sessions (p < 0.05). There was a significant decrease in ADA in GCF and
significant increases in CAT and GSH levels after SRP (p < 0.05) in all four
groups. The groups that were administered only gel (2nd and 4th) were different
from other groups in terms of ADA, CAT, and GSH levels at 1st week (p < 0.05).
Conclusion: HA application as an adjunct to SRP did not affect the clinical
results, although, in the control sessions following the application, the results
were favorable for the biochemical data in gel-applied groups. Trial registration:
ClinicalTrials.gov.tr (NCT03754010).
AN - rayyan-563560075
AU - Aydinyurt, H. S.
AU - Akbal, D.
AU - Altindal, D.
AU - Bozoglan, A.
AU - Ertugrul, A. S.
AU - Demir, H.
DO - 10.1007/s11845-020-02230-6
IS - 4
KW - NCT03754010
adenosine deaminase
catalase
gengigel
glutathione
hyaluronic acid
hydrogel
mouthwash
sodium chloride
adult
article
clinical article
controlled study
dental scaling
drug effect
enzyme activity
gingivitis
human
human tissue
periodontitis
root planing
spectrophotometry
surface area
LA - English
PY - 2020
SN - ["1863-4362", "0021-1265"]
SP - 1485-1494
ST - Evaluation of biochemical and clinical effects of hyaluronic acid on non-
surgical periodontal treatment: a randomized controlled trial
T2 - Ir. J. Med. Sci.
TI - Evaluation of biochemical and clinical effects of hyaluronic acid on non-
surgical periodontal treatment: a randomized controlled trial
VL - 189
ID - 13449
ER -
TY - JOUR
AB - Objective. This study investigates the antibacterial effect of essential oil
extracted from the gum of Pistacia atlantica Kurdica against Porphyromonas
gingivalis and histological evaluation of an experimental gel of the extract in
wound healing in the back subcutaneous tissue of Wistar rats. Methods. Clinical
strains of bacteria obtained from subgingival plaque samples of individuals having
periodontitis, isolation, and confirmation were done by conventional
microbiological tests and molecular technique. Essential oil was extracted by using
hydrodistillation method; antibacterial activity has been determined by two fold
serial dilution method. Histological evaluation conducted on fifteen Wistar rats.
Incisions were made on the dorsal surface of each animal for implanting of 3
polysilicone tubes (empty, tetracycline gel, and the experimental gel). After 1, 4,
and 8 weeks, the animals were euthanized and the specimens were prepared
histologically. Result. The extract demonstrated antimicrobial effect and
significant wound healing in the different study durations particularly our product
showed progression in epidermal wound healing and decrease in cellularity and
scoring of inflammatory cells. Conclusion. The extract was able to pose inhibitory
and bactericidal activity against P. gingivalis and the experimental gel was able
to have a good wound healing that enable it to be considered as a compatible
material.
AN - rayyan-563560221
AU - Azeez, S. H.
AU - Gaphor, S. M.
DO - 10.1155/2019/9195361
KW - essential oil
plant gum
silicone
wound healing promoting agent
animal experiment
animal model
animal tissue
article
bacterium isolation
biocompatibility
dilution
DNA isolation
drug isolation
drug synthesis
histology
histopathology
hydrodistillation
incision
inflammation
male
microbiological examination
nonhuman
periodontitis
Pistacia
Pistacia atlantica kurdica
rat
wound healing
LA - English
PY - 2019
SN - ["2314-6141", "2314-6133"]
ST - Evaluation of antibacterial effect against porphyromonas gingivalis and
biocompatibility of essential oil extracted from the gum of pistacia atlantica
Kurdica
T2 - BioMed Res. Int.
TI - Evaluation of antibacterial effect against porphyromonas gingivalis and
biocompatibility of essential oil extracted from the gum of pistacia atlantica
Kurdica
VL - 2019
ID - 13595
ER -
TY - JOUR
AB - For treatment of periodontal diseases, the local delivery of antimicrobials
into periodontal pocket has been shown to be more effective than the systemic
delivery. However, the major challenge for the formulators is the removal of the
delivery system from the application side due to the salivation as well as the
movement of the tongue. Mucoadhesive polymers have been successfully utilized to go
over this obstacle. In recent years, particularly chitosan has been widely
investigated for periodontal delivery systems not only for its mucoadhesive
properties but also for its antimicrobial activity. In our study, we developed a
local delivery system for an antimicrobial drug, moxifloxacin hydrochloride (MF),
at 0.5.% w/v, using chitosan for the treatment of periodontal diseases. For
comparison, formulations based on two other mucoadhesive polymers,
carbomer(Carbopol 940) and hydroxypropyl methylcellulose(HPMC) were also prepared.
Viscosity, mucoadhesion, drug release and permeation properties as well as the
antimicrobial activity of the gel formulations was evaluated in vitro. The
developed formulations with a suitable viscosity for application were found to
remain on the mucosa and release the drug in a prolonged fashion. Drug release from
the formulations was found to be dependent on the viscosity of the formulations. A
relative correlation was found between viscosity and mucoadhesion for the polymers
investigated, with an order of HPMC>Carbopol (R)=Chitosan. Permeation of the drug
was increased in presence of chitosan. The antimicrobial activity of MF against
Staphylococcus aureus and Streptococcus mutans were found to be enhanced with the
developed formulations. The highest antimicrobial activity was observed with the
chitosan-based formulations, due to the synergic effect of chitosan itself. Our
results showed that chitosan based formulation is a promising local delivery system
for treatment of periodontal disease by increasing the effect of the drug due to
its mucoadhesive and penetration enhancing effect as well its antimicrobial
activity. Furthermore, with these properties the developed formulations will
provide reduced frequency of administration, which result in higher patient
compliance.
AN - rayyan-563562228
AU - Azeran, N. S. B.
AU - Zazali, N. D. B.
AU - Timur, S. S.
AU - Ozdogan, A. I.
AU - Ekizoglu, M.
AU - Sheshala, R.
AU - Dua, K.
AU - Sahu, P. S.
AU - Senel, S.
IS - 1
PY - 2017
SN - 0973-8622
SP - 157-169
ST - Moxifloxacin Loaded Chitosan Gel Formulations for the Treatment of
Periodontal Diseases
T2 - JOURNAL OF POLYMER MATERIALS
TI - Moxifloxacin Loaded Chitosan Gel Formulations for the Treatment of
Periodontal Diseases
VL - 34
Y2 - 1
ID - 15602
ER -
TY - JOUR
AB - BACKGROUND: Chitosan hydrogel has good biocompatibility, biodegradability and
antibacterial property, which can promote tissue healing and induce bone formation.
As a scaffold carrying growth factors, it can ensure the efficient and slow release
of exogenous growth factors. OBJECTIVE: To observe the effect of injectable
nano/chitosan/bone morphogenetic protein-2 composite to promote periodontal tissue
regeneration in rats. METHODS: Fifty-four Wistar rats were randomized into three
groups, and then chronic periodontitis model of the second molar was established.
After modeling, injectable nano/chitosan/bone morphogenetic protein-2 composite was
implanted into the periodontal tissue of the second molar in the experimental
group; injectable nano/chitosan hydrogel was implanted in the control grouop; and
nothing was implanted in the blank group. At 3, 6, 9 weeks after surgery, gingival
bleeding index, probing depth, and tooth mobility were detected. X-ray and
histopathological observations were carried out. RESULTS AND CONCLUSION: At 9 weeks
after surgery, the probing depth and tooth mobility were both lower in the
experimental group than the other two groups (P < 0. 05). In the experimental
group, the alveolar bone height was restored at the root bifurcations, bone
trabeculae were arranged densely and evenly, the newly formed periodontal ligament
and alveolar bone tissues were dense and equally distributed in the bone defect
area at 9 weeks after surgery, indicating a better restoration effect than the
control and blank groups. These findings suggest that the injectable
nano/chitosan/bone morphogenetic protein-2 composite has an anti-inflammatory role
and can guide periodontal tissue regeneration.
AN - rayyan-563560408
AU - Ba, G. N.
AU - Chen, H. R.
AU - Li, T.
AU - Xie, F. Q.
AU - Yu, L. H.
DO - 10.3969/j.issn.2095-4344.2015.38.021
IS - 38
KW - bone morphogenetic protein 2
chitosan
nanocomposite
alveolar bone
animal experiment
animal model
animal tissue
article
controlled study
gingival bleeding index
histopathology
hydrogel
nonhuman
rat
LA - Chinese
PY - 2015
SN - 1673-8225
SP - 6184-6189
ST - Injectable nano/chitosan/bone morphogenetic protein-2 induces periodontal
tissue regeneration
T2 - Chin. J. Tissue Eng. Res.
TI - Injectable nano/chitosan/bone morphogenetic protein-2 induces periodontal
tissue regeneration
VL - 19
ID - 13782
ER -
TY - JOUR
AB - Background: The gold standard treatment of periodontal diseases is scaling
and root planing (SRP). Different adjunctive root conditioning agents such as
hyaluronic acid (HA), ethylenediaminetetraacetic acid (EDTA), and chlorhexidine
(CHX) have been used with SRP to improve the smear layer removal and the healing of
periodontal tissues. The aim of this study was to compare the effect of manual
scaling with or without HA, EDTA, or CHX root conditioning on the attachment and
viability of human gingival fibroblasts (GF). Methods: Fifteen healthy single
rooted teeth were co llected and divided randomly into a scaled (n = 12) and non-
scaled control group (n = 3). The scaled roots were subdivided equally into four
groups; the first group did not receive any chemical treatment, while the remaining
groups were treated with the conditioning agents HA or 17% EDTA or 0.2% CHX gel.
Gingival fibroblasts were seeded on the top of each root and incubated for 48 h to
allow attachment to the roots. The viability of fibroblasts attached to the root
surface was assessed using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-
diphenyltetrazolium bromide) cell viability assay. Results: The cell viability was
the highest in the scaled only group (p = 0.0001) while the lowest was in the
scaled with EDTA group (p > 0.05). The scaled group was the highest followed by the
HA and CHX groups, while the EDTA group showed the lowest mean value. Conclusion:
SRP remains the superior method for regaining cell attachment to the root surface,
leading to better periodontal health, and adjunctive therapies did not enhance the
GF attachment to the root surface beyond the effect of SRP. Further studies are
needed to investigate the effect of root conditioning agents on periodontally
diseased teeth in vitro and compare them in vivo.
AN - rayyan-563559963
AU - Babgi, W.
AU - Alhajaji, M.
AU - Al-Mehmadi, L.
AU - Elbaqli, R.
AU - Khayat, N.
AU - Aldahlawi, S.
AU - Youssef, A. R.
DO - 10.1016/j.sdentj.2020.03.009
IS - 6
KW - diamond burr
tooth crown
chlorhexidine
edetic acid
hyaluronic acid
adult
article
cell adhesion
cell viability
cell viability assay
clinical article
controlled study
crown lengthening
dental patient
dental surgery
fibroblast
gingiva
gingival tissue
gold standard
human
human cell
human tissue
MTT assay
periodontal disease
root planing
tooth extraction
tooth root
wound healing
LA - English
PY - 2021
SN - 1013-9052
SP - 342-347
ST - Effect of root conditioning agents hyaluronic acid, EDTA and chlorhexidine on
the attachment of human gingival fibroblasts to healthy root surface
T2 - Saudi Dent. J.
TI - Effect of root conditioning agents hyaluronic acid, EDTA and chlorhexidine on
the attachment of human gingival fibroblasts to healthy root surface
VL - 33
ID - 13337
ER -
TY - JOUR
AB - The cytotoxicity of the nitric oxide donor, S-nitroso-N-acetylpenicillamine
(SNAP), towards cultured human cells from oral tissue was evaluated. The toxicity
of SNAP to Smulow-Glickman gingival epithelial cells was correlated with the
liberation of nitric oxide, as N-acetyl-D,L- penicillamine, the SNAP metabolites,
N-acetyl-D,L-penicillamine disulfide and nitrite, and preincubated (denitrosylated)
SNAP did not affect viability. Comparing equimolar concentrations of various nitric
oxide donors, cytotoxicity appeared to be inversely related to the relative
stability (i.e., half-life) of the test compound; the sequence of cytotoxicity for
a 4 hr exposure was S-nitrosoglutathione>>spermine NONOate> SNAP>DPTA NONOate>>DETA
NONOate. Intracellular reduced glutathione (GSH) was lowered in S-G cells exposed
to SNAP. Pretreatment of the cells with the GSH depleter, 1,3-bis-(chloroethyl)-1-
nitrosourea (BCNU), enhanced the toxicity of SNAP. Similar findings of enhanced
sensitivity to SNAP were noted with gingival fibroblasts and periodontal ligament
cells pretreated with BCNU. The toxicity of SNAP towards the gingival epithelial
cells was decreased by cotreatment with the antioxidants, N-acetyl-L-cysteine, L-
ascorbic acid, and (+)- catechin. Cells exposed to SNAP exhibited nuclear
aberrations, including multilobed nuclei and multinucleation. SNAP-induced cell
death was apparently by apoptosis, as noted by fluorescence microscopy and DNA
agarose gel electrophoresis.
AN - rayyan-563561006
AU - Babich, H.
AU - Zuckerbraun, H. L.
AU - Hirsch, S. T.
AU - Blau, L.
DO - 10.1111/j.1600-0773.1999.tb01486.x
IS - 5
KW - acetylcysteine
antioxidant
ascorbic acid
carmustine
catechin
glutathione
n acetyl s nitrosopenicillamine
n acetylpenicillamine
nitric oxide
nitric oxide donor
nitrite
penicillamine disulfide
s nitrosoglutathione
spermine
apoptosis
article
cell nucleus
controlled study
drug cytotoxicity
epithelium cell
fibroblast
fluorescence microscopy
gingiva
human
human cell
mouth mucosa
priority journal
LA - English
PY - 1999
SN - 0901-9928
SP - 218-225
ST - In vitro cytotoxicity of the nitric oxide donor, S-nitroso-N-acetyl-
penicillamine, towards cells from human oral tissue
T2 - Pharmacol. Toxicol.
TI - In vitro cytotoxicity of the nitric oxide donor, S-nitroso-N-acetyl-
penicillamine, towards cells from human oral tissue
VL - 84
ID - 14380
ER -
TY - JOUR
AB - The integrity and function of the periodontium can be compromised by
traumatic injuries or periodontitis. Currently available clinical therapies are
able to stop the progression of periodontitis and allow the healing of periodontal
tissue. However, an optimal strategy capable of restoring the anatomy and
functionality of the lost periodontal tissue is still to be achieved. Herein is
proposed the development of an injectable hydrogel system able to release a growth
factors and cells to the periodontal defect. This injectable system is based on a
photocrosslinkable hydrogel, prepared from methacrylated hyaluronic acid (me-HA)
and incorporating platelet lysate (PL). The delivery of growth factors and cells in
situ is expected to enhance regeneration of the periodontium. Various formulations
of me-HA containing increasing PL concentrations were studied for achieving the
formation of stable photocrosslinkable hydrogels. The produced hydrogels were
subsequently characterized to assess mechanical properties, degradation,
protein/growth factor release profile, antimicrobial activity and response toward
human Periodontal Ligament fibroblasts (hPDLFs). The results demonstrated that it
was possible to obtain stable photocrosslinkable hydrogels incorporating different
amounts of PL that can be released in a sustained manner. Furthermore, the
incorporation of PL improved (p < 0.02) the viscoelastic properties of the
hydrogels and enhanced their resilience to the degradation by hyaluronidase
(HAase). Additionally, the PL was shown to provide antimicrobial properties.
Finally, hPDLFs, either seeded or encapsulated into the developed hydrogels, showed
enhanced proliferation over time (p < 0.05), proportionally to the increasing
amounts of PL present in the hydrogel formulations.
AN - rayyan-563562258
AU - Babo, P. S.
AU - Pires, R. L.
AU - Santos, L.
AU - Franco, A.
AU - Rodrigues, F.
AU - Leonor, I.
AU - Reis, R. L.
AU - Comes, M. E.
DO - 10.1021/acsbiomaterials.6b00508
IS - 7
PY - 2017
SN - 2373-9878
SP - 1359-1369
ST - Platelet Lysate-Loaded Photocrosslinkable Hyaluronic Acid Hydrogels for
Periodontal Endogenous Regenerative Technology
T2 - ACS BIOMATERIALS SCIENCE & ENGINEERING
TI - Platelet Lysate-Loaded Photocrosslinkable Hyaluronic Acid Hydrogels for
VL - 3
Y2 - 7
ID - 15632
ER -
TY - JOUR
AB - The integrity and function of the periodontium can be compromised by
traumatic injuries or periodontitis. Currently available clinical therapies are
able to stop the progression of periodontitis and allow the healing of periodontal
tissue. However, an optimal strategy capable of restoring the anatomy and
functionality of the lost periodontal tissue is still to be achieved. Herein is
proposed the development of an injectable hydrogel system able to release a growth
factors and cells to the periodontal defect. This injectable system is based on a
photocrosslinkable hydrogel, prepared from methacrylated hyaluronic acid (me-HA)
and incorporating platelet lysate (PL). The delivery of growth factors and cells in
situ is expected to enhance regeneration of the periodontium. Various formulations
of me-HA containing increasing PL concentrations were studied for achieving the
formation of stable photocrosslinkable hydrogels. The produced hydrogels were
subsequently characterized to assess mechanical properties, degradation,
protein/growth factor release profile, antimicrobial activity and response toward
human Periodontal Ligament fibroblasts (hPDLFs). The results demonstrated that it
was possible to obtain stable photocrosslinkable hydrogels incorporating different
amounts of PL that can be released in a sustained manner. Furthermore, the
incorporation of PL improved (p < 0.02) the viscoelastic properties of the
hydrogels and enhanced their resilience to the degradation by hyaluronidase
(HAase). Additionally, the PL was shown to provide antimicrobial properties.
Finally, hPDLFs, either seeded or encapsulated into the developed hydrogels, showed
enhanced proliferation over time (p < 0.05), proportionally to the increasing
amounts of PL present in the hydrogel formulations.
AN - rayyan-563560295
AU - Babo, P. S.
AU - Pires, R. L.
AU - Santos, L.
AU - Franco, A.
AU - Rodrigues, F.
AU - Leonor, I.
AU - Reis, R. L.
AU - Gomes, M. E.
DO - 10.1021/acsbiomaterials.6b00508
IS - 7
KW - fibroblast growth factor 2
hyaluronic acid
hyaluronidase
methacrylic acid
article
Bacillus megaterium
Candida albicans
cell encapsulation
cell lysate
confocal microscopy
controlled study
enzyme degradation
Escherichia coli
fibroblast
human
human cell
hydrogel
immersion
methicillin resistant Staphylococcus aureus
nonhuman
priority journal
proton nuclear magnetic resonance
thrombocyte
tissue regeneration
vancomycin resistant Staphylococcus aureus
body weight loss
Young modulus
LA - English
PY - 2017
SN - 2373-9878
SP - 1359-1369
ST - Platelet Lysate-Loaded Photocrosslinkable Hyaluronic Acid Hydrogels for
T2 - ACS Biomater. Sci. Eng.
TI - Platelet Lysate-Loaded Photocrosslinkable Hyaluronic Acid Hydrogels for
VL - 3
ID - 13669
ER -
TY - JOUR
AB - Garlic has been used medicinally throughout human history. Allicin is
considered the most therapeutic constituent of garlic. This study tested the
antimicrobial activity of garlic allicin on oral pathogens associated with dental
caries and periodontitis. Allicin was found effective against all the tested
bacteria. The broth dilution method revealed that planktonic growth of the
cariogenic, gram-positive species Streptococcus mutans, S. sobrinus, and
Actinomyces oris was inhibited by an allicin concentration of 600μg/mL or higher.
Planktonic growth of the tested gram-negative periopathogenic species
Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum was inhibited by
a minimum allicin concentration of 300μg/mL. Porphyromonas gingivalis, an
anaerobic, gram-negative pathogen and the bacterium most associated with chronic
periodontitis, demonstrated the lowest sensitivity to allicin (2,400μg/mL). Gel
zymography and the synthetic chromogenic substrate Nα- benzoyl-L-arginine 4-
nitroanilide hydrochloride demonstrated that allicin inhibits the proteases of P.
gingivalis, including the arginine and lysine gingipains known as major virulence
factors of this organism. A gingipain-inactivated mutant demonstrated high
sensitivity to allicin (<300μg/mL), revealing that gingipains confer resistance to
allicin. Live/dead staining followed by analysis with confocal laser scanning
microscopy revealed that allicin was bactericidal to S. mutans grown in mature
biofilms. However, this bactericidal effect was reduced as biofilm depth increased.
In conclusion, these results support the traditional medicinal use of garlic and
suggest the use of allicin for alleviating dental diseases. © Copyright 2011, Mary
Ann Liebert, Inc. and Korean Society of Food Science and Nutrition 2011.
AN - rayyan-563560574
AU - Bachrach, G.
AU - Jamil, A.
AU - Naor, R.
AU - Tal, G.
AU - Ludmer, Z.
AU - Steinberg, D.
DO - 10.1089/jmf.2010.0165
IS - 11
KW - allicin
antiinfective agent
arginine
benzoylarginine 4 nitroanilide
lysine
proteinase
virulence factor
Actinomyces
Actinomyces oris
article
bactericidal activity
biofilm
broth dilution
chronic disease
dental caries
drug sensitivity
garlic
nonhuman
periodontitis
plankton
priority journal
staining
Streptococcus sobrinus
zymography
LA - English
PY - 2011
SN - ["1096-620X", "1557-7600"]
SP - 1338-1343
ST - Garlic allicin as a potential agent for controlling oral pathogens
T2 - J. Med. Food
TI - Garlic allicin as a potential agent for controlling oral pathogens
VL - 14
ID - 13948
ER -
TY - JOUR
AB - Background: Tooth avulsion is one of the most severe dental traumas which
most often occur in children. When immediate replantation is not possible, storage
in a proper media may lead to a prolonged survival rate. Aloe Vera is a cactus like
plant with green, tapered leaves that are filled with a transparent viscous gel.
This medicinal plant has significant anti-inflammatory, antioxidant, antibacterial
and antifungal effects. The purpose of this study was to assess the effectiveness
of different concentrations of Aloe Vera extract compared to DMEM (cell culture
medium) and egg white. Methods: The periodontal ligament (PDL) cells were cultured
and certain number of cells were treated with Aloe Vera extract (in four different
concentrations), egg white and culture media for 1, 3, 6, and 9 hours. Cell
viability was determined by using the (3-[4, 5-dimethylthiazolyl-2]-2, 5-
diphenyltetrazolium bromide) assay. Moreover, One-way ANOVA and post hoc (LSD) test
were used for analyzing the study groups. Results: The results indicate that
culture media and Aloe Vera extract (10, 30, and 50% concentration) were
statistically similar and significantly preserved more PDL cells compared to other
experimental storage media. Conclusion: Aloe Vera 10, 30, and 50% may be
recommended as a suitable storage media for avulsed teeth.
AN - rayyan-563560443
AU - Badakhsh, S.
AU - Eskandarian, T.
AU - Esmaeilpour, T.
IS - 4
KW - Aloe vera extract
egg white
article
avulsed tooth storage media
cell culture
cell viability
controlled study
culture medium
dental device
human
human cell
MTT assay
normal human
periodontal ligament cell
preservation and storage
tooth injury
LA - English
PY - 2014
SN - ["1735-3688", "0253-0716"]
SP - 327-332
ST - The use of Aloe Vera extract as a novel storage media for the avulsed tooth
T2 - Iran. J. Med. Sci.
TI - The use of Aloe Vera extract as a novel storage media for the avulsed tooth
VL - 39
ID - 13817
ER -
TY - JOUR
AB - Introduction: Dental plaque has been established as an etiological factor in
the development of gingivitis and periodontitis. Several antimicrobials including
Chlorhexidine and Metronidazole have been used as an adjuvant to mechanical plaque
removal. Objective: To compare 0.8% Metronidazole gel, 0.2% Chlorhexidine gel and
alternate application of the two gels in reducing gingival inflammation when used
for 14 days as an adjuvant with home based oral hygiene instructions. Methods: The
bleeding sites, probing depth and the gingival index score will be calculated.
(Group A standard 0.2% Chlorhexidine gel applied on the marginal gingiva; Group B
subjects will be instructed to apply 0.8% Metronidazole gel; Group C subjects 0.2%
Chlorhexidine gel on the marginal gingiva after morning tooth brushing and 0.8%
Metronidazole gel after evening tooth brushing). After 2 weeks second clinical
examination will be carried out for bleeding sites, probing depth and the gingival
index score. Scaling & polishing of teeth in all three groups and oral hygiene
instructions will be reinforced. Subjects will be recalled at 6 weeks for
evaluation of gingival and oral hygiene indices. Descriptive statistics for
variables such as age, baseline clinical parameters including probing depth,
bleeding sites, gingival index, and oral hygiene index will be computed.
Generalized estimation equation (GEE) will be run to account for the correlated
data for the comparison of study arms. Friedman test will be used to assess the
bleeding sites among three study groups at the baseline and endpoint. Similarly,
gingival index and oral hygiene index in the three groups at baseline, after 2
weeks and 4 weeks will be compared. The level of significance will be kept at 0.05.
AN - rayyan-563560207
AU - Badar, S. B.
AU - Zafar, K.
AU - Ghafoor, R.
AU - Khan, F. R.
DO - 10.1016/j.isjp.2019.04.001
chlorhexidine
metronidazole
article
biofilm
clinical examination
comparative study
controlled study
data analysis
dental polishing
dental scaling
evening dosage
gingiva bleeding
gingival index
gingivitis
human
hypertrophy
interrater reliability
morning dosage
mouth hygiene
mouth ulcer
periodontitis
priority journal
tooth brushing
tooth plaque
treatment outcome
LA - English
PY - 2019
SN - 2468-3574
SP - 30-33
ST - Comparative evaluation of Chlorhexidine, Metronidazole and combination gels
on gingivitis: A randomized clinical trial
T2 - Int. J. Surg. Protoc.
TI - Comparative evaluation of Chlorhexidine, Metronidazole and combination gels
on gingivitis: A randomized clinical trial
VL - 14
ID - 13581
ER -
TY - JOUR
AB - Tobacco smoking is considered one of the most significant environmental risk
factors for destructive periodontal disease. The effect of smoking on
periodontopathic microbiota has not yet been elucidated, as previous studies failed
to identify a concrete relationship between periodontopathic microorganisms and
smoking. However, it is likely that smoking, as an environmental stress factor, may
affect the behavior of dental plaque microorganisms, ultimately leading to
alteration of the host-parasite interaction. The goal of this study was to examine
the effect of nicotine, a major component of tobacco, on the growth and protein
expression of the crucial periodontal pathogen Porphyromonas gingivalis. The growth
of P. gingivalis 381 was measured after bacterial cells were cultivated in liquid
broth containing various nicotine concentrations. First, P. gingivalis cells were
allowed to grow in the presence of a single dose of nicotine (the single exposure
protocol) at 0, 1, 2, 4, and 8 mg/L, respectively. Second, P. gingivalis cells were
exposed to five consecutive doses of nicotine (the multiple exposure protocol) at
0, 1, 2, and 4 mg/L, respectively. Bacterial growth was measured by optical density
and protein expression was analyzed by SDS-PAGE and 2-D gel electrophoresis. In the
single nicotine exposure protocol, it was observed that the growth of P. gingivalis
381 was inhibited by nicotine in a dose-dependent manner. In the multiple nicotine
exposure protocol, the growth rate of P. gingivalis increased with each subsequent
nicotine exposure, even though bacterial growth was also inhibited in a dose
dependent fashion. SDS-PAGE and 2-D gel electrophoresis analyses revealed a minor
change in the pattern of protein expression, showing differences in proteins with
low molecular weights (around 20 kDa) on exposure to nicotine. The results of this
study suggest that nicotine exerts an inhibitory effect on the growth of P.
gingivalis, and has a potential to modulate protein expression in P. gingivalis. ©
2012 The Microbiological Society of Korea and Springer-Verlag Berlin Heidelberg.
AN - rayyan-563560557
AU - Baek, O.
AU - Zhu, W.
AU - Kim, H. C.
AU - Lee, S. W.
DO - 10.1007/s12275-012-1212-8
IS - 1
bacterial protein
nicotine
proteome
article
drug effect
growth, development and aging
human
metabolism
spectrophotometry
tobacco
LA - English
PY - 2012
SN - ["1225-8873", "1976-3794"]
SP - 143-148
ST - Effects of nicotine on the growth and protein expression of Porphyromonas
gingivalis
T2 - J. Microbiol.
TI - Effects of nicotine on the growth and protein expression of Porphyromonas
gingivalis
VL - 50
ID - 13931
ER -
TY - JOUR
AB - The aim of the present study was to increase the solubility of an anti-
bactarial drug azithromycin by making its inclusion complex with hydroxy propyl β-
cyclodextrin and to develop it's biodegradable in situ gel so as to overcome first-
pass effect and consequently enhance its bioavailability. Periodontitis is an
inflammatory condition affecting teeth resulting in progressive destruction of
periodontal ligaments, resorption of alveolar bone and loss of teeth. Treatment of
periodontitis includes surgical and non surgical management. Systemic antibiotics
are also used for the treatment of periodontitis. Azithromycin dihydrate, used
systemically in the treatment of periodontitis, was formulated into in situ gel
using biodegradable, thermosensitive polymer Pluronic® F-127 (PF-127) and Hydroxy
Ethyl Cellulose (HEC) as copolymer. The formulation was characterized in terms of
in vitro gelling capacity, viscosity, rheology, content uniformity, in vitro drug
release, and syringeability. The prepared smart gels were clear and transparent,
sterile, thermoresponsive and injectable. Viscosity of gels increased with increase
in concentration of polymer/co-polymer and also with temperature. They gelled in
short response time below the body temperature. In vitro release studies showed
controlled drug release which was influenced significantly by the properties and
concentration of PF-127 and HEC. The developed azithromycin smart gel system with
complex formation is a novel approach for the treatment of chronic periodontitis
since it reduces the dose and side effects,and also providing continuous and
prolonged release of active material.
AN - rayyan-563560348
AU - Bagada, H. L.
AU - Raval, M. K.
AU - Sheth, N. R.
IS - 3
azithromycin
polymer
propane
cyclodextrin
antibiotic agent
poloxamer
copolymer
ethyl cellulose
experimental design
pharmaceutics
periodontitis
in vitro study
tooth
viscosity
first pass effect
bioavailability
temperature
drug release
alveolar bone
surgery
inflammation
flow kinetics
solubility
reaction time
body temperature
complex formation
side effect
LA - English
PY - 2016
SN - 0975-1491
SP - 40
ST - Formulation development of smart gel periodontal drug delivery system for
local delivery of antimicrobial agent with application of experimental design
TI - Formulation development of smart gel periodontal drug delivery system for
local delivery of antimicrobial agent with application of experimental design
VL - 8
ID - 13722
ER -
TY - JOUR
AB - Royal jelly (RJ) is one of the most valued natural products and is known for
its health-promoting properties. Due to its therapeutic effects, it has been used
in medicine since antiquity. Nowadays, several studies indicate that RJ acts as a
powerful antimicrobial agent. Indeed, researchers shed light on its antioxidant and
anticancer activity. RJ’s biological properties are related to its bioactive
compounds, such as proteins, peptides, phenolic, and fatty acids. The aim of this
review is to highlight recent findings on RJ’s main bioactive compounds correlated
with its health-promoting properties. The available literature suggests that these
bioactive compounds can be used as an alternative approach in order to enhance
human health. Moreover, throughout this paper, we underline the prominent
antibacterial effect of RJ against several target bacterial strains. In addition,
we briefly discuss other therapeutic activities, such as antioxidative and
anticancer effects, of this outstanding natural product.
AN - rayyan-563559831
AU - Bagameri, L.
AU - Baci, G. M.
AU - Dezmirean, D. S.
IS - 6
antioxidant
carbohydrate
doxycycline
gentamicin
meticillin
natural product
nutraceutical
penicillin derivative
polypeptide antibiotic agent
pyocyanine
royal jelly
virulence factor
Antiquity
anxiety
Bacillus subtilis
bacterial strain
bioavailability
blood pressure
cystic fibrosis
depression
diarrhea
Enterobacter cloacae
Escherichia coli
gel filtration chromatography
gingivitis
hospital infection
hyperandrogenism
ion exchange chromatography
Klebsiella pneumoniae
Listeria monocytogenes
membrane fluidity
membrane permeability
molecular weight
mouth cavity
nonhuman
ovary polycystic disease
Paenibacillus larvae
periodontitis
prevalence
Prevotella intermedia
renal cell carcinoma
reversed phase high performance liquid chromatography
review
Staphylococcus epidermidis
systematic review
Treponema denticola
wound healing
LA - English
PY - 2022
SN - 1999-4923
ST - Royal Jelly as a Nutraceutical Natural Product with a Focus on Its
Antibacterial Activity
T2 - Pharmaceutics
TI - Royal Jelly as a Nutraceutical Natural Product with a Focus on Its
Antibacterial Activity
VL - 14
ID - 13205
ER -
TY - JOUR
AB - In-situ gel forming formulations are a novel concept of providing drugs to
individuals as a liquid dosage form yet achieving sustained release of the drug for
the required duration. Different polymer based distribution schemes have been
created that can boost the residence time of the product at the drug absorption
location. These formulations exist as a flowing system before administration and at
the physiological environment it gets converted into viscoelastic gel. The
available therapies are to minimize the bacterial infection and to regenerate the
damage done by infection and inflammation. The therapies involve systemic therapy,
conventional therapy, as well as local therapy. Aim of the present work was to
formulate in-situ gel of ofloxacin and it is evaluated for antibacterial activity
and stability and it showed good antibacterial activity for both gram positive and
gram negative microorganisms and was stable at refrigerated temperature over three
months. The results indicated that the formulation could be utilized to maintain
the localized drug concentration for a longer period and increase patient
compliance with lesser adverse effects.
AN - rayyan-563559968
AU - Baghwan, R. R.
AU - Ambekar, A. W.
AU - Tamboli, S. S.
DO - 10.52711/0974-360X.2021.00801
IS - 9
KW - carbomer
carbopol 934
citrate sodium
disodium hydrogen phosphate
gel
gellan
hydrogel
ofloxacin
poloxamer
polymer
potassium dihydrogen phosphate
article
bacterial infection
calibration
colony forming unit
computer aided design
controlled study
crystallization
disk diffusion
drug absorption
drug development
drug formulation
drug penetration
drug release
drug solubility
drug stability
drug synthesis
Escherichia coli
excipient compatibility
Fourier transform mass spectrometry
gelling time
glucose blood level
inflammation
nonhuman
periodontitis
pH
physical chemistry
surface property
systemic therapy
tablet property
viscosity
zone of inhibition
LA - English
PY - 2021
SN - ["0974-360X", "0974-3618"]
SP - 4609-4614
ST - Formulation, development and evaluation of in-situ periodontal gel containing
ofloxacin
TI - Formulation, development and evaluation of in-situ periodontal gel containing
ofloxacin
VL - 14
ID - 13342
ER -
TY - JOUR
AB - Aim: Periodontitis (PD) is the sixth most prevalent disease around the world
and is involved in the development and progression of multiple systemic diseases.
Previous studies have reported that PD may aggravate liver injuries. The objective
of this study was to investigate whether and how PD affects liver fibrosis.
Materials and Methods: Ligature-induced PD (LIP) was induced in male C57/B6J mice,
and sub-gingival plaques (PL) from patients with PD were applied to mouse teeth.
Liver fibrosis was induced by carbon tetrachloride (CCl4) injection. The mice were
randomly divided into six groups: Oil, Oil+LIP, Oil+LIP+PL, CCl4, CCl4+LIP, and
CCl4+LIP+PL. Alveolar bone resorption was evaluated by methylene blue staining.
Hepatic function was analysed by serum alanine aminotransferase and hepatic
hydroxyproline. Picrosirius red and α-smooth muscle actin (SMA) staining were used
to evaluate the fibrotic area. RNA sequencing and quantitative RT-PCR were used to
measure gene expression. Western blotting was used to measure protein levels. Flow
cytometry was used to analyse the accumulation of immune cells. Mouse microbiota
were analysed using 16S rRNA gene sequencing. Results: Mice in the CCl4+LIP+PL
group displayed higher serum alanine aminotransferase and hepatic hydroxyproline as
well as more Picrosirius red-positive and α-SMA-positive areas in liver samples
than those of the CCl4 group, suggesting that PD (LIP+PL) aggravated CCl4-induced
hepatic dysfunction and liver fibrosis. Consistently, the expression of fibro-genic
genes and the protein levels of transforming growth factor β were much higher in
the CCl4+LIP+PL group than in the CCl4 group. Flow cytometry revealed that PD
increased the accumulation of immune cells, including Kupffer cells, B cells, and
Th17 cells, in the liver of mice with CCl4 treatment. PD also increased the
expression of inflammatory genes and activated pro-inflammatory nuclear factor-
kappa B pathway in the livers of CCl4-injected mice. Moreover, PD altered both oral
and liver microbiota in CCl4-injected mice. Conclusions: PD aggravates CCl4-induced
hepatic dysfunction and fibrosis in mice, likely through the increase of
inflammation and alteration of microbiota in the liver.
AN - rayyan-563559799
AU - Bai, L.
AU - Wang, Y. L.
AU - Chen, Y. L.
AU - Li, H. X.
AU - Zhu, S. W.
AU - Liu, Y.
AU - Song, Z. C.
AU - Duan, S. Z.
DO - 10.1111/jcpe.13682
IS - 10
KW - biochemical equipment
flow cytometer
Leica KL300
LightCycler 480II
microscope
NC2000
polymerase chain reaction system
spectrophotometer
alanine aminotransferase
alpha smooth muscle actin
aspartate aminotransferase
brefeldin A
carbon tetrachloride
CD11b antigen
CD3 antibody
CD4 antigen
CD45RA antigen
CD8 antigen
collagenase
glyceraldehyde 3 phosphate dehydrogenase (NADP)
hydroxyproline
immunoglobulin G
inflammasome
interleukin 17
interleukin 6
methylene blue
probiotic agent
RANTES
RNA 16S
short chain fatty acid
synaptotagmin I
transcriptome
transforming growth factor beta
tubulin
adult
alveolar bone
alveolar bone loss
animal cell
animal model
animal tissue
artery ligation
article
bioinformatics
cementoenamel junction
controlled study
differential gene expression
DNA extraction
flow cytometry
gene expression
gene mapping
gene ontology
gene sequence
hepatic stellate cell
histology
immunofluorescence
immunohistochemistry
inflammation
Leptotrichia buccalis
liver dysfunction
liver fibrosis
liver function
liver injury
male
microbial community
morphology
mouse
mouth flora
NF kB signaling
nonhuman
periodontal pocket
periodontitis
plaque index
protein expression
risk factor
RNA analysis
RNA extraction
RNA sequence
RNA sequencing
signal transduction
tooth plaque
Western blotting
LSRFortessa
LA - English
PY - 2022
SN - ["1600-051X", "0303-6979"]
SP - 1067-1078
ST - The combination of experimental periodontitis and oral microbiota from
periodontitis patients aggravates liver fibrosis in mice
TI - The combination of experimental periodontitis and oral microbiota from
periodontitis patients aggravates liver fibrosis in mice
VL - 49
ID - 13173
ER -
TY - JOUR
AB - Objective: Serious skin wound such as the extensive full-thickness wounds
usually leads to pain, infections and even amputation severely affects people's
life and health. Wound healing is a complex process generally consisting of early
inflammation, cellular proliferation, and tissue remodeling requires the efforts of
cells, growth factors and extracellular signals. An excellent wound dressing to
heal severe wounds is critical to accelerate the recovery of skin integrity and
functional state. Owing to the existence of PDA NPs, the hydrogel could deliver PUE
and maintain the drug in the hydrogel network for a long period. The aim of this
study is to evaluate the therapeutic efficacy of the PEG-DA/PDA/PUE hydrogel on
skin wound healing and to explore the mechanism of wound healing. Methods: The PEG-
DA/PDA/PUE hydrogels were fabricated by the incorporation of PDA/PUE NPs and the
photo-polymerization of PEG-DA in an aqueous solution with an initiator. For
morphological characterization, the composite hydrogels after swelling in water
were freeze-dried using a freeze drier. And then, the hydrogels were observed by
scanning electron microscope (SEM,Q25, FEI) to study the pores and network of the
hydrogels. The swelling rate and the degradation rate of hydrogels were measured by
the gravimetric method. At prearranged time periods the swollen hydrogel was
weighed, and the mass loss of hydrogels was measured. The water vapor transmission
rate (WVTR) was measured in accordance with the ASTM E96-95 standard, which was
measured by the weight loss of water. And, the mechanical properties of these
samples were performed on Instron tensile strength tester (INSTRON, Model 5944)
with a speed of 10 mm/min. The stress-strain curve was then obtained. In vitro drug
release of hydrogel samples was carried out at 37°C. The concentration of PUE
solutions was analyzed at 250 nm by UV-Vis spectrophotometer. The antioxidant
capacity of hydrogels was measured by measuring hydroxyl radical scavenging
capacity. All experiments were performed in triplicates and the average values were
calculated. The biocompatibility of hydrogels was studied using MTT assay. After
sterilized via UV radiation, the hydrogels were immersed in the medium for 24 hours
at the extraction ratio of 5 mg/mL. After being filtered, the medium was incubated
with PDLSCs and DPSCs cells for 7 days. AfterMTT solution treatment, the absorbance
was detected at 490 nm by a plate reader.Meanwhile, the live/dead cell staining kit
was used to stain cells. Finally, the images of cells were get via fluorescence
microscopy. Results: In this study, PDA NPs and PDA/PUE NPs were prepared and their
FT-IR spectra. And, the morphology of PDA NPs and PDA/PUE NPs was characterized by
TEM. The particles were approximately spherical with average diameters of
108±11.32, and 204±26.21 nm, respectively. And, the drug loading ratio of PUE on
PDA NPs was 8.01±2.08%, which was determined at 250 nm by the UV spectra. The water
evaporated due to the porous structure of these hydrogels. The WVTR data of three
hydrogels were 2364.67±97.67, 2344.51±106.39, 2561.23±157.71 g/m2/day,
respectively. An ideal wound dressing should keep the skin evaporation and water
loss rates at an optimum level. It was reported that the WVTR of normal skin ranges
from 240 to 1920 g/m2/day at 37°C. Moreover, the damaged skin had a high rate of
water vapor transmission, which could lead to rapid drying of wounds and create new
wounds on the skin. Therefore, it was inferred that the prepared hydrogels could be
suitable for treatment of skin wound as dressing. The compressive strength was one
of the key factors affecting the application of hydrogels. In compression tests,
the stress-strain curves of hydrogels. The compressive modulus of hydrogels was
changed with the addition of PDA/PUE NPs. The Young's modulus of three hydrogels
was 0.37±0.06, 0.50±0.13, and 0.54±0.07 MPa, respectively. In comparison to the
PEG-DA hydrogels, PEG-DA/PDA/PUE hydrogels improved the mechanical performance.
Further, the antioxidative capacit of PEG-DA/PDA/PUE hydrogels was evaluated. Under
the excessive ROS production, cellular biomolecules were seriously oxidative
damage, resulting in the destruction of cellular oxidation/antioxidant balance. In
this study, the expression of SOD, GPx, and MDA as the oxidative stress indicators
was investigated to elucidate the cellular antioxidant mechanism. SOD plays a key
role in oxidation/antioxidant balance, which can remove superoxide anions and free
radical, and repair damaged cells timely. The SOD activity was measured by WST-8
method. After the DPSCs cells treated with hydrogel for 24 hours, the values of SOD
activity were 0.47±0.02, 0.50±0.04, 0.54±0.01 and 0.57±0.02 U/mg protein,
corresponding to control, PEG-DA, PEGDA/PDA/PUE(L), and PEG-DA/PDA/PUE(H),
respectively. And, the values of SOD activity were also detected to be improved in
the DPSCs cells after hydrogel treatment. The increased of cellular SOD activity
was attributed to the antioxidant properties of PEGDA/PDA/PUE hydrogels.And, GPx is
one of the most important enzymes in oxidative and antioxidant system.34 The
results of GPx activity were significant. After the PDLSCs cells treated with
hydrogel for 24 hours, the values of GPx activities in each group were 1.89±0.02,
1.92±0.01, 2.07±0.01 and 2.11±0.01 mU/mg protein, respectively. The activities of
GPx treated with PEGDA/PDA/PUE(H) hydrogel was obviously higher than that treated
with PEG-DA hydrogel. The similar results were observed in DPSCs cells after
hydrogel treatment for 24 hours. In addition, after PEG-DA/PDA/PUE(L) hydrogel
treated PDLSCs and DPSCs cells for 48 hours, the activities of GPx were
significantly higher than that treated with other groups. In test groups, the
increase of GPx activity was attributed to the antioxidative hydrogels protecting
cells. The PEG-DA/PDA/PUE hydrogels could scavenge free radicals and protect cells,
which was consistent with the results of cellular SOD activity. Conclusions: In
this study, the antioxidant hydrogel as wound dressing had been developed. Owing to
the existence of PDA NPs as antioxidant drug carriers, the hydrogel could load
puerarin and maintain the drug in the three dimensional network for a long period.
The hydrogels possessed the excellent swelling capacity, and showed the favorable
mechanical property as wound dressing. And, In vitro study supported that the PEG-
DA/PDA/PUE hydrogels were conducive to cell growth.Thus, the investigation of PEG-
DA/PDA/PUE(H) hydrogels could be used as a candidate material for wound skin
healing and regeneration.
AN - rayyan-563559820
AU - Bai, M.
AU - Wang, H.
AU - Liu, J.
DO - 10.1111/ajco.13830
KW - antioxidant
drug carrier
endogenous compound
free radical
glutathione peroxidase
hydrogel
hydroxyl radical
puerarin
superoxide
water
aqueous solution
biocompatibility
body weight loss
cell culture
cell growth
compression
compressive strength
conference abstract
controlled study
destruction
drug release
enzyme activity
evaporation
extraction ratio
human
human cell
in vitro study
microplate reader
MTT assay
oxidation
oxidative stress
periodontal ligament stem cell
polymerization
protein expression
scanning electron microscope
signal transduction
skin injury
surgery
swelling
tensile strength
TGF beta signaling
ultraviolet spectrophotometer
velocity
water vapor
wound dressing
wound healing
LA - English
PY - 2022
SN - 1743-7563
SP - 49-51
ST - Primary Study on the Effect of Puerarin on Skin Healing Through TGF-beta
Signalling Pathway
T2 - Asia-Pac. J. Clin. Oncol.
TI - Primary Study on the Effect of Puerarin on Skin Healing Through TGF-beta
Signalling Pathway
VL - 18
ID - 13194
ER -
TY - JOUR
AB - Thirty patients took part in a 4 week 'double-blind' clinical trial.
Following initial oral hygiene instruction and scaling, half the patients were
instructed to brush with a 1% chlorhexidine gel in the evenings, the other half to
use placebo. A standard dentifrice was used in the morning. In both groups there
was a marked improvement in all parameters recorded, and although final plaque
scores showed a statistically significant difference in favor of the test group,
there was virtually no difference in rate or degree of resolution of gingivitis.
The use of a standard dentifrice was only partially successful in preventing
staining.
AN - rayyan-563561197
AU - Bain, M. J.
AU - Strahan, J. D.
DO - 10.1902/jop.1978.49.9.469
IS - 9
KW - chlorhexidine
placebo
drug therapy
gel
gingivitis
mouth
periodontal disease
periodontitis
periodontosis
therapy
tooth
corsodyl
LA - English
PY - 1978
SN - 0022-3492
SP - 469-474
ST - The effect of A 1% chlorhexidine gel in the initial therapy of chronic
periodontal disease
TI - The effect of A 1% chlorhexidine gel in the initial therapy of chronic
periodontal disease
VL - 49
ID - 14571
ER -
TY - JOUR
AB - Featured Application:& nbsp;an antibacterial and adhesive hydrogel is
developed to inject inside dental implant connections in order to limit bacterial
proliferation and periimplant diseases. Background: Periimplantitis is a disease
linked to oral virulent bacteria such as P. gingivalis that grow in dental implants
surrounding tissues and between implants and abutments. Antimicrobial gels
previously described to fill these sites lose their effectiveness and resorb over
time. Objective: Characterization of biophysical and antimicrobial properties of an
original hydrogel, Alginate-Catechol (Alg-Cat), combined to D-Cateslytin (D-CTL).
Methods: Gelation kinetics, frequency and strain sweep measurements were performed
by rheology. Antibacterial activity of the gels was tested against P. gingivalis,
and the MIC was determined. Peptides released from the gels were purified by HPLC
and characterized by MALDI-TOF mass spectrometry. The behavior of bacteria in
contact with the gel was observed using optical and electronic microscopy (SEM and
TEM). Results: Gelation was fast and was achieved in 2 min with a storage modulus
between 25 and 30 Pa. The gels were stable under strain and showed an adhesive
potential reinforced with aging at 18 h (5.4 kPa) under a slow retraction speed (4
J & BULL;m(-2) at 10 mu m/s) with a mixed rupture profile (adhesive/cohesive). The
MIC of D-CTL inside the Alg-Cat gel against P. gingivalis was equal to 470 mu g &
BULL;mL(-1) after 24 h. Peptides recovered in the supernatant and inside the gel
were fragmented, most of them conserving the ?-helix active site. No bacteria were
visualized at the surface and inside the gel after 24 h. This gel is promising for
clinical application for the prevention of periimplantitis.
AN - rayyan-563562233
AU - Baixe, S.
AU - Ball, V.
AU - Jierry, L.
AU - Cianferani, S.
AU - Strub, J. M.
AU - Haikel, Y.
AU - Metz-Boutigue, M. H.
AU - Etienne, O.
DO - 10.3390/app112110050
IS - 21
PY - 2021
SN - 2076-3417
ST - Strongly Adhesive and Antimicrobial Peptide-Loaded, Alginate-Catechol-Based
Gels for Application against Periimplantitis
T2 - APPLIED SCIENCES-BASEL
TI - Strongly Adhesive and Antimicrobial Peptide-Loaded, Alginate-Catechol-Based
Gels for Application against Periimplantitis
VL - 11
Y2 - 11
ID - 15607
ER -
TY - JOUR
AB - Several epidemiologic studies have identified a greater incidence of
periodontitis in patients with type 2 diabetes. Recent developments suggest that
local delivery of antimicrobials into periodontal pockets improve periodontal
health. The present study was designed to investigate the adjunctive effects of
subgingivally delivered clarithromycin (CLM) (0.5% concentration) as an adjunct to
scaling and root planing for treating chronic periodontitis in patients with well-
controlled type 2 diabetes. Sixty-three patients were categorized into two
treatment groups: Group 1, scaling and root planing (SRP) plus 0.5% CLM; Group 2,
SRP plus placebo gel. Clinical parameters were recorded at baseline, 1, 2, and 3
months; which included gingival index (GI), sulcus bleeding index (SBI), plaque
index (PI), probing depth (PD), and periodontal attachment level (PAL). Both
therapies resulted in significant improvements. Using a subject-based analysis,
patients in Group 1 treated with SRP + CLM showed enhanced reductions in PI, GI,
SBI, and PD, and gains in PAL (P < 0.001) over a period of 6 months as compared to
Group 2. Although both treatment strategies seemed to benefit the patients, the
adjunctive use of 0.5% CLM as a controlled drug delivery system enhanced the
clinical outcome. © 2012 Wiley Publishing Asia Pty Ltd.
AN - rayyan-563560522
AU - Bajaj, P.
AU - Pradeep, A. R.
AU - Agarwal, E.
AU - Kumari, M.
AU - Naik, S. B.
DO - 10.1111/j.2041-1626.2012.00168.x
IS - 4
clarithromycin
adult
article
controlled study
female
human
longitudinal study
male
methodology
middle aged
periodontal disease
periodontics
tooth plaque
treatment outcome
LA - English
PY - 2012
SN - 2041-1626
SP - 276-283
ST - Locally delivered 0.5% clarithromycin, as an adjunct to nonsurgical treatment
in chronic periodontitis with well-controlled type 2 diabetes: a randomized
T2 - J Investig Clin Dent
TI - Locally delivered 0.5% clarithromycin, as an adjunct to nonsurgical treatment
in chronic periodontitis with well-controlled type 2 diabetes: a randomized
VL - 3
ID - 13896
ER -
TY - JOUR
AB - A split-mouth double-blind trial was designed to compare the effects of
chlorhexidine and placebo gels during the healing phase following mucogingival flap
surgery. Fifteen patients were treated with 30 inverse bevel flap procedures, one
on each side of the maxilla, with an interval of 4 weeks between each procedure.
Gel was applied to the gums using a toothbrush once daily. Comparison of results
revealed no significant differences in Plaque Index, Gingival Index, crevicular
fluid or depth of pockets. More pain and swelling were recorded on the side treated
with placebo gel, and more patients indicated that they preferred the chlorhexidine
gel. The results were comparable to previous investigations using penicillin and
suggest that, because of the reduced pain and swelling, chlorhexidine gel may be a
suitable alternative to penicillin after periodontal flap surgery.
AN - rayyan-563561193
AU - Bakaeen, G. S.
AU - Strahan, J. D.
DO - 10.1111/j.1600-051X.1980.tb01945.x
IS - 1
KW - chlorhexidine
penicillin G
placebo
clinical trial
controlled study
gingiva
human
mouth
mouth reconstruction
surgery
therapy
wound healing
LA - English
PY - 1980
SN - 0303-6979
SP - 20-25
ST - Effects of a 1% chlorhexidine gel during the healing phase after inverse
bevel mucogingival flap surgery
TI - Effects of a 1% chlorhexidine gel during the healing phase after inverse
bevel mucogingival flap surgery
VL - 7
ID - 14567
ER -
TY - JOUR
AB - Unsatisfactory hygienic condition of mouth cavity is one of the main reasons
of periodontitis and gingivitis. The purpose of the investigation was the
evaluation of effectiveness of the product of Italian company "President" for
curing inflammatory diseases of the periodontal tissues. 42 patients aged from 18
to 65 were under observation. With the general and local anti-inflammatory
treatment they were prescribed the following tooth-pastes: President Active,
President Exclusive, and President Sensitive; rinses: President Profi, President
sensitive plus, gel for gums--President Sensitive Plus. We used unique
toothbrushes: President Gold, President z3, President Silver Care. The patients of
the second group used desired toothpastes, eliminators and toothbrushes. The
patients studied before and after the treatment was defined by the hygienic
indices: HI, OHI, GI, PI. Microbiological investigations have shown high
sensitivity of "President" product to Candida type fungi. Treatment results have
shown that the data of clinical indices in both groups came nearly up to the norm,
but in the first group its significance turned to be lower then in the second
group. According to the results of the investigation we can sum up that the product
of Italian company "President" secures essential improvement of hygienic state of
mouth cavity, has antimicrobial and anti-inflammatory effect and its using is
effective for curing and prophylaxis of periodontal tissues inflammatory disease.
AN - rayyan-563560768
AU - Bakhtadze, E.
AU - Gogilashvili, K.
IS - 136
KW - toothpaste
adolescent
adult
aged
article
human
devices
Italy
middle aged
mouth hygiene
periodontitis
tooth brushing
treatment outcome
LA - English
PY - 2006
SN - 1512-0112
SP - 39-41
ST - Usage of the product of the Italian company "President" for the treatment of
inflammatory diseases of periodontium
T2 - Georgian Med News
TI - Usage of the product of the Italian company "President" for the treatment of
inflammatory diseases of periodontium
ID - 14142
ER -
TY - CONF
AN - rayyan-563561975
AU - Bako, J.
AU - Szepesi, M.
AU - Borbely, Z. M.
AU - Hegedus, C.
AU - Borbely, J.
DA - 2007
SP - 409-412
ST - Synthesis of biocompatible nanocomposite hydrogel as a local drug delivery
system
T2 - 2007 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2007,
Technical Proceedings
TI - Synthesis of biocompatible nanocomposite hydrogel as a local drug delivery
system
34547995468&partnerID=40&md5=603a8ccc850e3bbc7a5f4e32eeae773a
VL - 2
ID - 15349
ER -
TY - JOUR
AB - Nanocomposite biocompatible hydrogels (NCHG) were synthesised as model
systems for in situ cured potentially local drug delivery devices for curing
periodontal infections. The composite consists of the following components:
nanoparticles (NPs), matrix gel, and chlorhexidine (CHX) as antibacterial drug. The
NPs were obtained by free radical initiated copolymerization of the monomers, 2-
hydroxyethyl methacrylate (HEMA) and polyethyleneglycol dimethacrylate (PEGDMA), in
aqueous solution. The same monomers were used to prepare crosslinked matrices by
photopolymerization. NCHGs were obtained by mixing NPs, monomers, and drug in an
aqueous solution then crosslinked by photopolymerization. Mechanical properties,
swelling behavior, and the kinetics of drug release have been investigated. It was
found that compression strength values increased with increasing ratio of the
crosslinker PEGDMA. Incorporation of NPs into the matrix resulted similar
compression strength as the matrix hydrogel. The hydrated NCHGs swelled more slowly
but admitted more water. The drug was incorporated in NPs by swelling in CHX
aqueous solution or added to the solution of monomer mixture followed by
photopolymerization. Studies of release kinetics revealed that on average 60% of
the loaded drug was released. The most rapid release was observed over a 24 h
period for matrix gels with low crosslinking density. For NCHGs, the release period
exceeded 48 h. An unexpected result was observed for NCHGs without drug in the NPs.
In this case, increasing release was observed for the first 24 h. Thereafter,
however, the apparent quantity of detectable drug decreased dramatically. ©
Springer-Verlag 2007.
AN - rayyan-563560721
AU - Bako, J.
AU - Szepesi, M.
AU - Veres, A. J.
AU - Cserhati, C.
AU - Borbely, Z. M.
AU - Hegedus, C.
AU - Borbely, J.
DO - 10.1007/s00396-007-1793-7
IS - 3
KW - 2 hydroxyethyl methacrylate
chlorhexidine
macrogol
nanocomposite
nanoparticle
article
dentistry
drug efficacy
drug release
human
hydrogel
implant
light scattering
periodontal disease
polymerization
priority journal
LA - English
PY - 2008
SN - 0303-402X
SP - 357-363
ST - Synthesis of biocompatible nanocomposite hydrogels as a local drug delivery
system
T2 - Colloid Polym. Sci.
TI - Synthesis of biocompatible nanocomposite hydrogels as a local drug delivery
system
VL - 286
ID - 14095
ER -
TY - JOUR
AB - The in situ application of the combination of different types of drugs
revolutionized the area of periodontal therapy. The purpose of this study was to
develop nanocomposite hydrogel (NCHG) as a pH-sensitive drug delivery system. To
achieve local applicability of the NCHG in dental practice, routinely used blue-
light photopolymerization was chosen for preparation. The setting time was 60 s,
which resulted in stable hydrogel structures. Universal Britton–Robinson buffer
solutions were used to investigate the effect of pH in the range 4–12 on the
release of drugs that can be used in the periodontal pocket. Metronidazole was
released from the NCHGs within 12 h, but chlorhexidine showed a much longer elution
time with strong pH dependence, which lasted more than 7 days as it was
corroborated by the bactericidal effect. The biocompatibility of the NCHGs was
proven by Alamar-blue test and the effectiveness of drug release in the acidic
medium was also demonstrated. This fast photo-polymerizable NCHG can help to
establish a locally applicable combined drug delivery system which can be loaded
with the required amount of medicines and can reduce the side effects of the
systemic use of drugs that have to be used in high doses to reach an ideal
concentration locally.
AN - rayyan-563559853
AU - Bako, J.
AU - Toth, F.
AU - Gall, J.
AU - Kovacs, R.
AU - Csík, A.
AU - Varga, I.
AU - Sculean, A.
AU - Zelko, R.
AU - Hegedus, C.
IS - 5
KW - buffer
chlorhexidine
metronidazole
nanohydrogel
unclassified drug
universal Britton Robinson buffer
acidity
article
biocompatibility
biodegradability
blue light
controlled study
dental practice
drug release
drug safety
elution
Escherichia coli
human
human cell
MG-63 cell line
nonhuman
periodontal pocket
periodontitis
pH sensitive drug delivery system
photopolymerization
polymerization
resazurin assay
LA - English
PY - 2022
SN - 1999-4923
ST - Combined Release of Antiseptic and Antibiotic Drugs from Visible Light
Polymerized Biodegradable Nanocomposite Hydrogels for Periodontitis Treatment
T2 - Pharmaceutics
TI - Combined Release of Antiseptic and Antibiotic Drugs from Visible Light
Polymerized Biodegradable Nanocomposite Hydrogels for Periodontitis Treatment
VL - 14
ID - 13227
ER -
TY - JOUR
AB - Biodegradable polymers are compatible, permeable and nontoxic, thus they can
provide a useful tool for drug delivery or tissue engineering. These polymers can
form hydrogels, which are suitable vehicles for different types of materials e.g.
drugs, bioactive molecules or cells. In the case of dentistry, photopolymerization
is an obvious method to obtain in situ useable devices which can provide a more
efficient way of tailoring drug release. A hydrogel system was developed based on
poly-gamma-glutamic acid that was modified with methacryloyl groups to achieve this
purpose. The resulting new reactive structure was proved by NMR spectroscopy. The
swelling ratio of this type of hydrogel has been found remarkable, over 300 % after
24 h, and it can release 5 ng/mm2 metronidazole. The prepared hydrogels were
nontoxic as viability, cytotoxicity tests and cell morphology investigations proved
it. These results render this model system an excellent candidate for use as an in
situ curing local drug delivery device. The new photoactive system can be utilized
in the treatment of periodontal diseases or raising the effectiveness of drugs used
only in the minimal effective dose. © 2012 Springer Science+Business Media New
York.
AN - rayyan-563560511
AU - Bakó, J.
AU - Vecsernyés, M.
AU - Ujhelyi, Z.
AU - Kovácsné, I. B.
AU - Borbíró, I.
AU - Bíró, T.
AU - Borbély, J.
AU - Hegedűs, C.
DO - 10.1007/s10856-012-4825-x
IS - 3
KW - methacrylated polyglutamic acid
metronidazole
polyglutamic acid
polymer
unclassified drug
article
biocompatibility
cell viability
chemical composition
controlled study
dentistry
drug release
hydrogel
keratinocyte
photopolymerization
polymerization
priority journal
LA - English
PY - 2013
SN - ["1573-4838", "0957-4530"]
SP - 659-666
ST - Composition and characterization of in situ usable light cured dental drug
delivery hydrogel system
TI - Composition and characterization of in situ usable light cured dental drug
delivery hydrogel system
VL - 24
ID - 13885
ER -
TY - JOUR
AN - rayyan-563562102
AU - Balamurugan, A.
AU - Balossier, G.
AU - Laurent-Maquin, D.
AU - Pina, S.
AU - Rebelo, A. H. S.
AU - Faure, J.
AU - Ferreira, J. M. F.
DO - 10.1016/j.dental.2008.02.015
IS - 10
PY - 2008
SP - 1343-1351
ST - An in vitro biological and anti-bacterial study on a sol-gel derived silver-
incorporated bioglass system
T2 - Dental Materials
TI - An in vitro biological and anti-bacterial study on a sol-gel derived silver-
48749119517&doi=10.1016%2fj.dental.2008.02.015&partnerID=40&md5=0162f26bd143928d25c
3da89a95ea626
VL - 24
ID - 15476
ER -
TY - JOUR
AB - OBJECTIVES: The purpose of this study was to evaluate the in vitro
antibacterial and biological activity of silver-incorporated bioactive glass system
SiO2-CaO-P2O5-Ag2O (AgBG). The bacteriostatic and bactericidal properties of this
new quaternary glass system along with the ternary sol-gel glass system SiO2-CaO-
P2O5 (BG) have been studied using Escherichia coli as a test micro-organism. The
AGBG system thus appears to be a promising material for dental applications, since
similar effects might be produced on a film of bacteria and mucous that grows on
the teeth. METHODS: The SiO2-CaO-P2O5-Ag2O and SiO2-CaO-P2O5 glass systems were
synthesized by the sol-gel technique and characterized for their physicho-chemical
properties. The antibacterial activity and biological properties were evaluated by
determining the minimum inhibitory concentrations (MICs). Release of Ag+ into the
culture medium was measured by inductively coupled plasma (ICP) analysis. RESULTS:
The in vitro antibacterial action of the SiO2-CaO-P2O5-Ag2O was compared with that
of its ternary counterpart glass system. The concentrations of Ag-bioglass, in the
range of 0.02-0.20 mg of Ag-bioglass per millilitre of culture medium, were found
to inhibit the growth of these bacteria. The Ag-bioglass not only acts
bacteriostatically but it also elicited a rapid bactericidal action. A complete
bactericidal effect was elicited in the early stages of the incubation at Ag-
bioglass concentration of 20 mg/ml and the ternary glass system had no effect on
bacterial growth or viability. The antibacterial action of Ag-bioglass was
exclusively attributed to the leaching of Ag+ ions from the glass matrix.
SIGNIFICANCE: One of the major advantages of incorporating silver ions into a gel
glass system is that the porous glass matrix can allow for controlled sustained
delivery of the antibacterial agent to dental material, used even under anaerobic
conditions such as deep in the periodontal pocket. This glass system also provides
long-term action required for systems which are constantly at risk of microbial
contamination.
AN - rayyan-563560698
AU - Balamurugan, A.
AU - Balossier, G.
AU - Laurent-Maquin, D.
AU - Pina, S.
AU - Rebelo, A. H.
AU - Faure, J.
AU - Ferreira, J. M.
DO - 10.1016/j.dental.2008.02.015
IS - 10
bioglass
biomaterial
disilver oxide
glass
oxide
silver derivative
SiO2 CaO P2O5 Ag2O
SiO2-CaO-P2O5-Ag2O
unclassified drug
article
atomic absorption spectrometry
ceramics
chemistry
diffusion
drug effect
electron probe microanalysis
Escherichia coli
gel
human
materials testing
physical chemistry
porosity
solubility
surface property
LA - English
PY - 2008
SN - 0109-5641
SP - 1343-1351
ST - An in vitro biological and anti-bacterial study on a sol-gel derived silver-
T2 - Dent Mater
TI - An in vitro biological and anti-bacterial study on a sol-gel derived silver-
VL - 24
ID - 14072
ER -
TY - JOUR
AB - Aim: Aim of the present study was to assess the efficacy of two local drug
delivery systems in the treatment of chronic periodontitis. Materials and Methods:
A total of 40 patients aged around 30–55 years were included in the present
study.The enrolled patients underwent initial phase therapy which comprised scaling
and root planning done by a single operator. Patients who fulfilled the selection
criteria for the study were randomly allocated to two groups. Group 1: Tetracycline
Fibers, Group 2: Chlorhexidine Gel. The plaque index (PI), the gingival index (GI),
and periodontal pocket depth (PPD) were noted during baseline visit (before the
local drug delivery), and these indices were rerecorded after 30 days after the
local drug delivery. Results: The reduction of mean plaque index score was seen
more in group 1 compared to group 2. There was no statistically significant
difference found between the groups. The reduction of mean gingival index score and
periodontal pocket depth was seen maximum in group 1 compared to group 2. There was
a statistically significant difference found between the groups after the
intervention. Conclusion: The present study concluded that, although thorough
scaling and root planing are effective treatment methods for elimination of chronic
periodontal pockets, improved results can be obtained by adjunctive use of locally
administered tetracycline fibers and chlorhexidine gel.
AN - rayyan-563560104
AU - Bankur, P. K.
AU - Avdhoot, K.
AU - Jha, S.
AU - Jalaluddin, M.
AU - Kumari, D.
AU - Soans, C. R.
IS - 11
KW - adult
article
clinical article
controlled study
female
gingival index
human
male
plaque index
root planing
tetracycline
LA - English
PY - 2020
SN - 2515-8260
SP - 7137-7143
ST - Assessment of the Efficacy of Two Local Drug Delivery Systems in the
Treatment of Chronic Periodontitis
TI - Assessment of the Efficacy of Two Local Drug Delivery Systems in the
Treatment of Chronic Periodontitis
VL - 7
ID - 13478
ER -
TY - JOUR
AB - The aim of the paper was to develop satranidazole-containing mucoadhesive gel
for the treatment of periodontitis. Different mucoadhesive gels were prepared,
using various gelling agents like sodium carboxymethylcellulose (SCMC), poloxamer
407, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose,
and the mucoadhesive polymer carbopol 934P. The selected formulations (based on the
mucoadhesive force) were studied for different mechanical properties, such as
mucoadhesive strength, hardness, compressibility, adhesiveness, and cohesiveness
through Texture Profile Analyzer. In vitro satranidazole release from the prepared
formulations was also determined and compared with marketed preparation of
metronidazole (Metrogyl® gel). The formulation SC30 (containing SCMC 3% w/v) showed
maximum mucoadhesive strength (167.72 ± 3.76 g) and adhesiveness (-46.23 ± 0.34
N∈mm), with low hardness (9.81 ± 0.04 N) and compressibility (40.05 ± 0.48 N∈mm)
and moderate cohesiveness (0.87 ± 0.01). SC30 formulation exhibited long-term
release. Thus, SC30 gel was evaluated for its clinical effectiveness along with
marketed metronidazole gel. At the end of the study (42 days of clinical studies),
both formulations were found to significantly reduce the probing depth, plaque
index, gingival index, calculus criteria, and bleeding index. However, the SC30 gel
was more effective in reducing the above parameters than marketed metronidazole
gel. This study confirmed the acceptability and effectiveness of satranidazole gel
for treatment of periodontitis. © 2009 American Association of Pharmaceutical
Scientists.
AN - rayyan-563560669
AU - Bansal, K.
AU - Rawat, M. K.
AU - Jain, A.
AU - Rajput, A.
AU - Chaturvedi, T. P.
AU - Singh, S.
DO - 10.1208/s12249-009-9260-z
IS - 3
KW - carbomer
metronidazole
poloxamer
satranidazole
adult
article
clinical article
clinical trial
controlled study
drug efficacy
drug formulation
drug hypersensitivity
drug release
drug safety
drug solubility
female
gel
gingiva bleeding
hardness
human
in vitro study
male
mucoadhesion
periodontitis
tooth plaque
metrogyl
LA - English
PY - 2009
SN - 1530-9932
SP - 716-723
ST - Development of satranidazole mucoadhesive gel for the treatment of
periodontitis
T2 - AAPS PharmSciTech
TI - Development of satranidazole mucoadhesive gel for the treatment of
periodontitis
VL - 10
ID - 14043
ER -
TY - JOUR
AB - BACKGROUND: This study aimed to formulate and characterize in-situ gel
containing levofloxacin and metronidazole to release drugs in controlled manner for
treatment of periodontitis. MATERIAL AND METHODS: Medicated in-situ gel with
levofloxacin (10% w/v), metronidazole (25% w/v) and vehicle in-situ gel without
drugs having poloxamer 407 (20% w/v) and chitosan (0.5%, 1%, 1.5%, 2.0% 2.5% w/v)
were prepared and characterized for physicochemical, mechanical properties,
stability and in-vitro drug release. Fourier transform infrared spectroscopy and
differential scanning calorimetery studies were done. Optimized formulation was
evaluated by scanning electron microscope (SEM) and in-vitro antimicrobial activity
against 5 bacterial strains. RESULTS: The results revealed that drugs and polymers
were compatible to formulate. All formulations were light yellow, clear and
syringeable except formulation having 2.5% w/v chitosan. pH was in the range of
6.20 to 6.74. 1.0% w/v and 1.5% w/v chitosan formulations showed gelation
temperature 37 ± 0.32 °C and 34 ± 0.21 °C. Further, mucoadhesive strength indicated
mucoadhesivity of gel. In-vitro release study of 1.5% w/v chitosan formulation
showed initial burst where about 55-60% MZ and 60-70% LVF got released within 6-
7 hrs followed by sustained release upto 48 hrs. SEM images of 1.5% w/v chitosan
optimized medicated in-situ and vehicle in-situ gel appeared similar indicating
homogeneous mixing of polymers with drugs. In-vitro antimicrobial study showed that
medicated in-situ gel was more effective than vehicle. CONCLUSIONS: In conclusion,
optimized 1.5% w/v chitosan in-situ gel was thermoresponsive, mucoadhesive,
syringeable, and released drugs in slow and controlled manner with effectiveness
against broad range of microbes.
AN - rayyan-563560941
AU - Bansal, M.
AU - Mittal, N.
AU - Yadav, S. K.
AU - Khan, G.
AU - Gupta, P.
AU - Mishra, B.
AU - Nath, G.
DO - 10.1016/j.jobcr.2017.12.005
IS - 2
J2 - J Oral Biol Craniofac Res
LA - eng
N1 - Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu
University, Varanasi, 221005, India.; Faculty of Dental Sciences, Institute of
Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.; Department of
Pharmaceutics, Indian institute of Technology, Banaras Hindu University, Varanasi,
221005, India.; Department of Pharmaceutics, Indian institute of Technology,
Banaras Hindu University, Varanasi, 221005, India.; Department of Microbiology,
Faculty of Medicine, Institute of Medical Sciences Banaras Hindu University,
Varanasi, 221005, India.; Department of Pharmaceutics, Indian institute of
Technology, Banaras Hindu University, Varanasi, 221005, India.; Department of
Microbiology, Faculty of Medicine, Institute of Medical Sciences Banaras Hindu
University, Varanasi, 221005, India.
PY - 2018
SN - 2212-4268 (Print)
SP - 126-133
ST - Periodontal thermoresponsive, mucoadhesive dual antimicrobial loaded in-situ
gel for the treatment of periodontal disease: Preparation, in-vitro
characterization and antimicrobial study
T2 - Journal of oral biology and craniofacial research
TI - Periodontal thermoresponsive, mucoadhesive dual antimicrobial loaded in-situ
gel for the treatment of periodontal disease: Preparation, in-vitro
characterization and antimicrobial study
VL - 8
Y2 - 5
ID - 14315
ER -
TY - JOUR
AB - Quaternary ammonium silane [(QAS), codename – k21] is a novel biomaterial
developed by sol-gel process having broad spectrum antimicrobial activities with
low cytotoxicity. It has been used in various concentrations with maximum
antimicrobial efficacy and biocompatibility. The antimicrobial mechanism is
displayed via contact killing, causing conformational changes within the bacterial
cell membrane, inhibiting Sortase-A enzyme, and causing cell disturbances due to
osmotic changes. The compound can attach to S1' pockets on matrix
metalloproteinases (MMPs), leading to massive MMP enzyme inhibition, making it one
of the most potent protease inhibitors. Quaternary ammonium silane has been
synthesized and used in dentistry to eliminate the biofilm from dental tissues. QAS
has been tested for its antibacterial activity as a cavity disinfectant, endodontic
irrigant, restorative and root canal medication, and a nanocarrier for drug
delivery approaches. The review is first of its kind that aims to discuss
applications of QAS as a novel antibacterial biomaterial for dental applications
along with discussions on its cytotoxic effects and future prospects in dentistry.
AN - rayyan-563559803
AU - Bapat, R. A.
AU - Parolia, A.
AU - Chaubal, T.
AU - Yang, H. J.
AU - Kesharwani, P.
AU - Phaik, K. S.
AU - Lin, S. L.
AU - Daood, U.
DO - 10.3389/fmicb.2022.927282
KW - 3m
ammonia
biomaterial
collagen
resin cement
bacterial clearance
bacterial membrane
bacterial viability
biocompatibility
bone development
cell membrane
cell viability
conformational transition
cytotoxicity
dental caries
dentistry
drug efficacy
drug release
encapsulation
enzyme activity
IC50
image analysis
microbial community
mouse
MTT assay
nonhuman
osteoblast
particle size
periodontal disease
review
sol-gel
tensile strength
tooth root canal
wettability
wound healing assay
X ray diffraction
XTT assay
zeta potential
zymography
LA - English
PY - 2022
SN - 1664-302X
ST - Recent Update on Applications of Quaternary Ammonium Silane as an
Antibacterial Biomaterial: A Novel Drug Delivery Approach in Dentistry
T2 - Front. Microbiol.
TI - Recent Update on Applications of Quaternary Ammonium Silane as an
Antibacterial Biomaterial: A Novel Drug Delivery Approach in Dentistry
VL - 13
ID - 13177
ER -
TY - JOUR
AB - Periodontal diseases are worldwide health problems that negatively affect the
lifestyle of many people. The long-term effect of the classical treatments,
including the mechanical removal of bacterial plaque, is not effective enough,
causing the scientific world to find other alternatives. Polymer-drug systems,
which have different forms of presentation, chosen depending on the nature of the
disease, the mode of administration, the type of polymer used, etc., have become
very promising. Hydrogels, for example (in the form of films, micro-/nanoparticles,
implants, inserts, etc.), contain the drug included, encapsulated, or adsorbed on
the surface. Biologically active compounds can also be associated directly with the
polymer chains by covalent or ionic binding (polymer-drug conjugates). Not just any
polymer can be used as a support for drug combination due to the constraints
imposed by the fact that the system works inside the body. Biopolymers, especially
polysaccharides and their derivatives and to a lesser extent proteins, are
preferred for this purpose. This paper aims to review in detail the biopolymer-drug
systems that have emerged in the last decade as alternatives to the classical
treatment of periodontal disease.
AN - rayyan-563559993
AU - Baranov, N.
AU - Popa, M.
AU - Atanase, L. I.
AU - Ichim, D. L.
DO - 10.3390/molecules26092735
IS - 9
biopolymer
cellulose
chitosan
cross linking reagent
drug carrier
nanoparticle
polysaccharide
animal
chemistry
dog
gel
human
hydrogel
kinetics
periodontal disease
periodontitis
rat
LA - English
PY - 2021
SN - 1420-3049
ST - Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis
T2 - Molecules
TI - Polysaccharide-Based Drug Delivery Systems for the Treatment of Periodontitis
VL - 26
ID - 13367
ER -
TY - JOUR
AN - rayyan-563561486
AU - Barbosa, E.
AU - Pires, P. G. S.
AU - Hauptli, L.
AU - Moraes, P.
DO - 10.1016/j.rvsc.2022.10.025
PY - 2023
SP - 8-14
ST - Strategies to improve the home care of periodontal disease in dogs: A
systematic review
T2 - Research in Veterinary Science
TI - Strategies to improve the home care of periodontal disease in dogs: A
systematic review
85141814440&doi=10.1016%2fj.rvsc.2022.10.025&partnerID=40&md5=9893c3dca2a18b0cf8592
4806882414a
VL - 154
ID - 14860
ER -
TY - JOUR
AB - OBJECTIVE: The objective of this work was to investigate in vivo the effects
of calcium hydroxide-based intracanal medication (ICM) on the levels of bacteria,
pro-inflammatory cytokines (PICs), and matrix metalloproteinases (MMPs) in root
canals and periradicular tissues of teeth with failure of the root canal treatment
and apical periodontitis. MATERIALS AND METHODS: Twenty infected root canals of
single-rooted teeth were randomly assigned into two groups according to the
irrigant used for chemomechanical preparation (CMP) (n = 10 per group): G1 - 2%
chlorhexidine (CHX) gel and G2 - 6% sodium hypochlorite (NaOCl). Root canal
contents were taken by using paper points before CMP (S1) and after 30 days of
calcium hydroxide-based ICM (S2). Microbial reduction was calculated by means of
colony-forming unit count (CFU/mL), with PICs and MMPs (pg/mL) being measured by
using enzyme-linked immunosorbent assay (ELISA). RESULTS: Culturable bacteria
(101.2 ± 79.2), PICs (IL-1β 1.2 ± 0.4 and TNF-α 8.8 ± 4.7), MMP-2 (803.7 ± 96.4),
MMP-3 (453.9 ± 229.3), MMP-8 (245.9 ± 122.4), MMP-9 (129.4 ± 29.6), and MMP-13
(70.8 ± 12.8) were present in all S1 samples. After 30 days of ICM (S2), a 99.5%
microbial reduction was observed, together with a significant reduction of PICs in
all groups. Overall, it was observed a decrease in the levels of MMPs (S2), except
MMP-13, which was found in increased levels after ICM (P < .05), independently of
the groups. CONCLUSIONS: Calcium hydroxide-based intracanal medications have had a
positive effect on the microbial reduction by decreasing the levels of PICs and
MMPs. Both auxiliary chemical substances (i.e., 2% CHX and 6% NaOCl) presented
similar effects when calcium hydroxide was used as intracanal medication. CLINICAL
RELEVANCE: Teeth with failure of the root canal treatment and apical periodontitis,
and consequently with high levels of bacteria, PIC, and MMP, may present a better
prognosis after a 30 days of a calcium hydroxide-based ICM.
AN - rayyan-563560188
AU - Barbosa-Ribeiro, M.
AU - Arruda-Vasconcelos, R.
AU - de-Jesus-Soares, A.
AU - Zaia, A. A.
AU - Ferraz, C. C. R.
AU - de Almeida, J. F. A.
AU - Gomes, B. P. F. A.
DO - 10.1007/s00784-018-2719-0
IS - 6
calcium hydroxide
chlorhexidine
cytokine
hypochlorite sodium
adult
bacterial count
bacterium
complication
controlled study
dental pulp cavity
human
metabolism
microbiology
middle aged
root canal preparation
LA - English
PY - 2019
SN - 1436-3771
SP - 2759-2766
ST - Effectiveness of calcium hydroxide-based intracanal medication on
infectious/inflammatory contents in teeth with post-treatment apical periodontitis
TI - Effectiveness of calcium hydroxide-based intracanal medication on
infectious/inflammatory contents in teeth with post-treatment apical periodontitis
VL - 23
ID - 13562
ER -
TY - JOUR
AB - Introduction: The infectious content of root canals, including bacteria and
lipoteichoic acid (LTA), cause injuries to the periapical tissues. The purpose of
this clinical study was to quantify the levels of both LTA and cultivable bacteria
at the different phases of endodontic retreatment (ER) of teeth with post-treatment
apical periodontitis. It also aimed to investigate the presence of gram-positive
microorganisms before and after chemomechanical preparation (CMP) and intracanal
medication (ICM). Methods: Twenty infected root canals of single-rooted teeth were
randomly assigned into 2 groups according to the chemical substance used for CMP (n
= 10 per group): chlorhexidine (CHX) group, 2% CHX gel, and the sodium hypochlorite
(NaOCl) group, 6% NaOCl. Root canal samples were taken using paper points before
(S1) and after CMP (S2) and after 30 days of ICM with calcium hydroxide + 2% CHX
gel (S3). Microorganisms were identified by the culture technique using biochemical
tests. Cultivable bacteria were determined by counting the colony-forming unit. LTA
levels were measured using the enzyme-linked immunosorbent assay (pg/mL). Results:
A total of 70 gram-positive species, out of 102 species isolated, were found in the
root canals (54 in S1, 4 in S2, and 12 in S3). Enterococcus faecalis was the most
frequent isolated taxon in all phases of the ER. LTA (574.0 +/- 94.7) and
cultivable bacteria (101.2 +/- 79.2) were present in all S1 samples. CMP decreased
the overall levels of cultivable bacteria by 99.4% and LTA by 24.8% (P < .05),
whereas the total overall reduction level of ICM on viable bacteria was 99.5% and
on LTA it was 38.6% (P < .05). CMP with 2% CHX gel (CHX group, 99.3%) was more
effective (P < .05) than 6% NaOCl (NaOCI group, 92.1%) on bacterial reduction.
Likewise, ICM showed a 100% reduction in the CHX group and 98.5% in the NaOCl
group. Regarding the reduction of LTA, CMP with 2% CHX gel (CHX group, 26.9%) was
more effective (P < .05) than 6% NaOCl (NaOCl group, 22.6%). In addition, ICM
showed a 43.2% reduction in the CHX group and 36.2% in the NaOCl group (P > .05).
Conclusions: The reduction rates of bacteria were higher than the LTA. Moreover,
gram-positive microorganisms were present in all phases of the endodontic
retreatment.
AN - rayyan-563562614
AU - De-Jesus-Soares, A.
AU - Zaia, A. A.
AU - Almeida, J. F. A.
AU - Gomes, Bpfa
DO - 10.1016/j.joen.2016.01.002
IS - 4
PY - 2016
SN - ["0099-2399", "1878-3554"]
SP - 552-556
ST - Quantification of Lipoteichoic Acid Contents and Cultivable Bacteria at the
Different Phases of the Endodontic Retreatment
TI - Quantification of Lipoteichoic Acid Contents and Cultivable Bacteria at the
VL - 42
Y2 - 4
ID - 15988
ER -
TY - JOUR
AB - INTRODUCTION: The infectious content of root canals, including bacteria and
lipoteichoic acid (LTA), cause injuries to the periapical tissues. The purpose of
this clinical study was to quantify the levels of both LTA and cultivable bacteria
at the different phases of endodontic retreatment (ER) of teeth with post-treatment
apical periodontitis. It also aimed to investigate the presence of gram-positive
microorganisms before and after chemomechanical preparation (CMP) and intracanal
medication (ICM). METHODS: Twenty infected root canals of single-rooted teeth were
randomly assigned into 2 groups according to the chemical substance used for CMP (n
= 10 per group): chlorhexidine (CHX) group, 2% CHX gel, and the sodium hypochlorite
(NaOCl) group, 6% NaOCl. Root canal samples were taken using paper points before
(S1) and after CMP (S2) and after 30 days of ICM with calcium hydroxide + 2% CHX
gel (S3). Microorganisms were identified by the culture technique using biochemical
tests. Cultivable bacteria were determined by counting the colony-forming unit. LTA
levels were measured using the enzyme-linked immunosorbent assay (pg/mL). RESULTS:
A total of 70 gram-positive species, out of 102 species isolated, were found in the
root canals (54 in S1, 4 in S2, and 12 in S3). Enterococcus faecalis was the most
frequent isolated taxon in all phases of the ER. LTA (574.0 ± 94.7) and cultivable
bacteria (101.2 ± 79.2) were present in all S1 samples. CMP decreased the overall
levels of cultivable bacteria by 99.4% and LTA by 24.8% (P < .05), whereas the
total overall reduction level of ICM on viable bacteria was 99.5% and on LTA it was
38.6% (P < .05). CMP with 2% CHX gel (CHX group, 99.3%) was more effective (P
< .05) than 6% NaOCl (NaOCl group, 92.1%) on bacterial reduction. Likewise, ICM
showed a 100% reduction in the CHX group and 98.5% in the NaOCl group. Regarding
the reduction of LTA, CMP with 2% CHX gel (CHX group, 26.9%) was more effective (P
< .05) than 6% NaOCl (NaOCl group, 22.6%). In addition, ICM showed a 43.2%
reduction in the CHX group and 36.2% in the NaOCl group (P > .05). CONCLUSIONS: The
reduction rates of bacteria were higher than the LTA. Moreover, gram-positive
microorganisms were present in all phases of the endodontic retreatment.
AN - rayyan-563560346
AU - Zaia, A. A.
AU - Ferraz, C. C.
AU - Almeida, J. F.
AU - Gomes, B. P.
DO - 10.1016/j.joen.2016.01.002
IS - 4
chlorhexidine
hypochlorite sodium
lipopolysaccharide
lipoteichoic acid
teichoic acid
adult
bacterium
chemistry
classification
dental pulp cavity
drug effect
human
metabolism
microbiology
middle aged
procedures
randomization
retreatment
LA - English
PY - 2016
SN - 1878-3554
SP - 552-556
ST - Quantification of Lipoteichoic Acid Contents and Cultivable Bacteria at the
T2 - J Endod
TI - Quantification of Lipoteichoic Acid Contents and Cultivable Bacteria at the
VL - 42
ID - 13720
ER -
TY - JOUR
AB - The 3 human salivary cystatins S, SA and SN are multifunctional proteins that
possess a cysteine protease inhibitory property, but their ability to act as such
is very different (SN > SA >> S). One form, S, also appears to possess
antibacterial properties towards the bacterium Porphyromonas gingivalis, often
associated with periodontal diseases. In this study we measured the total cystatin
inhibitory activity and the levels of each salivary cystatin in the whole saliva of
8 periodontally diseased patients and 2 groups of control subjects (n = 6 and n =
10). The total cystatin inhibitory activity and the total salivary cystatin
concentration in the periodontally diseased patients were found to be lower than
the controls (p < or = 0.005). The concentration of S was depleted to levels that
would not allow it to be an effective antibacterial agent, and the concentration of
SA, although depleted in some cases, was still present at sufficient levels to
allow it to act as an effective physiological inhibitor of cathepsin L. The
concentration of cystatin SN was also depleted in the periodontally diseased
patients, but was still present in sufficient quantities to act as an effective
physiological cysteine protease inhibitor of cathepsins H and L. In comparison, the
concentration of all 3 salivary cystatins in the control subjects were sufficient
to enable these proteins to be both effective physiological cysteine protease
inhibitors and antibacterial agents.
AN - rayyan-563561003
AU - Baron, A. C.
AU - Gansky, S. A.
AU - Ryder, M. I.
AU - Featherstone, J. D.
IS - 8
KW - cystatin
cysteine proteinase inhibitor
adult
aged
article
chemistry
comparative study
female
human
male
metabolism
middle aged
nonparametric test
periodontal disease
saliva
statistics
Western blotting
LA - English
PY - 1999
SN - 0022-3484
SP - 437-444
ST - Cysteine protease inhibitory activity and levels of salivary cystatins in
whole saliva of periodontally diseased patients
T2 - J. Periodont. Res.
TI - Cysteine protease inhibitory activity and levels of salivary cystatins in
VL - 34
ID - 14377
ER -
TY - COMP
AB - The 3 human salivary cystatins S, SA and SN are multifunctional proteins that
possess a cysteine protease inhibitory property, but their ability to act as such
is very different (SN > SA >> S). One form, S, also appears to possess
antibacterial properties towards the bacterium Porphyromonas gingivalis, often
associated with periodontal diseases. In this study we measured the total cystatin
inhibitory activity and the levels of each salivary cystatin in the whole saliva of
8 periodontally diseased patients and 2 groups of control subjects (n = 6 and n =
10). The total cystatin inhibitory activity and the total salivary cystatin
concentration in the periodontally diseased patients were found to be lower than
the controls (p < or = 0.005). The concentration of S was depleted to levels that
would not allow it to be an effective antibacterial agent, and the concentration of
SA, although depleted in some cases, was still present at sufficient levels to
allow it to act as an effective physiological inhibitor of cathepsin L. The
concentration of cystatin SN was also depleted in the periodontally diseased
patients, but was still present in sufficient quantities to act as an effective
physiological cysteine protease inhibitor of cathepsins H and L. In comparison, the
concentration of all 3 salivary cystatins in the control subjects were sufficient
to enable these proteins to be both effective physiological cysteine protease
inhibitors and antibacterial agents.
AN - rayyan-563561405
AU - Baron, A. C.
AU - Gansky, S. A.
AU - Ryder, M. I.
AU - Featherstone, J. D.
CY - United States
DO - 10.1111/j.1600-0765.1999.tb02279.x
ET - 8
J2 - J Periodontal Res
KW - Adult
Aged
Blotting, Western/statistics & numerical data
Cystatins/*analysis
Cysteine Proteinase Inhibitors/*analysis
Electrophoresis, Polyacrylamide Gel/statistics & numerical data
Female
Humans
Male
Middle Aged
Periodontal Diseases/*metabolism
Saliva/*chemistry
Statistics, Nonparametric
LA - eng
N1 - Department of Restorative Dentistry, University of California, San Francisco
94143-0758, USA.
PY - 1999
SN - 0022-3484 (Print)
SP - 437-44
T2 - Journal of periodontal research
VL - 34
Y2 - 11
ID - 14779
ER -
TY - JOUR
AN - rayyan-563562128
AU - Baron, A. C.
AU - Gansky, S. A.
AU - Ryder, M. I.
AU - Featherstone, J. D. B.
DO - 10.1111/j.1600-0765.1999.tb02279.x
IS - 8
PY - 1999
SP - 437-444
T2 - Journal of Periodontal Research
0033218035&doi=10.1111%2fj.1600-
0765.1999.tb02279.x&partnerID=40&md5=ec172879431948767ed9abe95ee33b0f
VL - 34
ID - 15502
ER -
TY - JOUR
AB - The aim of this study was to determine the antibacterial effectiveness of
either chlorhexidine or calcium hydroxide integrated in gutta-percha points
compared with chlorhexidine or calcium hydroxide delivered as gel or paste,
respectively. A total of 70 initially sterile roots with open accesses were carried
for 1 week in the oral cavities of two volunteers. The roots were then removed, and
samples were taken from the root canals for microbial analysis. The roots were
medicated with calcium hydroxide paste, 5% chlorhexidine gel, or a chlorhexidine-
or calcium hydroxide-containing gutta-percha point. The accesses were closed with
bonding material, and the roots incubated for 1 week. After removal of the
antimicrobial agents, roots were again checked for bacterial growth. One
thioglycolate-soaked paper point was then introduced into each canal, and roots
were incubated for 1 week more to observe bacterial regrowth. After 1 week of
medication, the absolute bacterial count revealed significant differences compared
with the controls. However, only the chlorhexidine-gel and the calcium hydroxide
paste group showed no microbial colonization in a considerable number of samples
after 1 and 2 weeks.
AN - rayyan-563562390
AU - Barthel, C. R.
AU - Zimmer, S.
AU - Zilliges, S.
AU - Schiller, R.
AU - Gobel, U. B.
AU - Roulet, J. F.
DO - 10.1097/00004770-200206000-00002
IS - 6
PY - 2002
SN - 0099-2399
SP - 427-430
ST - In situ antimicrobial effectiveness of chlorhexidine and calcium hydroxide:
Gel and paste versus gutta-percha points
TI - In situ antimicrobial effectiveness of chlorhexidine and calcium hydroxide:
Gel and paste versus gutta-percha points
VL - 28
Y2 - 6
ID - 15764
ER -
TY - JOUR
AB - Objective - To investigate the source of infections associated with
orthopaedic prostheses. Design - Analysis of four infections of prosthetic joints
with case records; minimum inhibitory and minimum bactericidal concentrations and
sodium dodecylsulphate polyacrylamide gel electrophoresis of the cell wall
polypeptides of the Streptococcus sanguis isolates from the mouth and infected
prostheses; examination of the patients' mouths for periodontal disease and caries.
Subjects - Four adults (three men) aged 58-83. Results - For each patient the
strain of S sanguis isolated from the mouth was indistinguishable from that
isolated from the prosthesis. All patients had severe periodontal disease and
caries. Conclusions - The mouth was probably the source of bacterial infection in
the prosthetic joints of these patients; the route of infection was possibly
haematogenous. Incipient oral infection should be treated before joint replacement,
and oral health should be maintained indefinitely.
AN - rayyan-563561079
AU - Bartzokas, C. A.
AU - Johnson, R.
AU - Jane, M.
AU - Martin, M. V.
AU - Pearce, P. K.
AU - Saw, Y.
IS - 6953
KW - amoxicillin
antibiotic agent
clindamycin
erythromycin
penicillin G
tetracycline
adult
aged
article
case report
female
human
infection control
joint prosthesis
male
mouth hygiene
mouth infection
postoperative infection
priority journal
LA - English
PY - 1994
SN - 0959-8146
SP - 506-508
ST - Relation between mouth and haematogenous infection in total joint
replacements
T2 - BR. MED. J.
TI - Relation between mouth and haematogenous infection in total joint
replacements
VL - 309
ID - 14453
ER -
TY - JOUR
AB - Objectives The aim of this systematic review and meta-analysis was to
evaluate the efficacy of indocyanine green-mediated photodynamic therapy (ICG-PDT)
as an adjunct to non-surgical periodontal therapy (NSPT), in the management of
chronic periodontitis. Materials and methods Four electronic databases (PubMed,
Cochrane Central Register of Controlled Trials, Embase via OVID, Web of Science)
were searched for randomised controlled trials comparing NSPT with ICG-PDT to NSPT
without laser therapy. Primary outcome measures were changes in probing pocket
depth (PPD) and clinical attachment level (CAL). Clinical outcomes were extracted
and pooled from 7 eligible trials and meta-analyses conducted using mean difference
with standard deviations. Results For PPD, adjunctive ICG-PDT resulted in a mean
additional reduction of 1.17 mm (95% CI: 0.67-1.66 mm) at 3 months and a mean
additional reduction of 1.06 mm (95% CI: 0.54-1.57 mm) at 6 months. For CAL,
adjunctive ICG-PDT resulted in a mean additional gain of 0.70 mm (95% CI: 0.17-1.23
mm) at 3 months and a mean additional gain of 1.03 mm (95% CI: 0.83-1.24 mm) at 6
months. No adverse events were reported in any studies. Conclusions The adjunctive
use of ICG-PDT in NSPT results in improved treatment outcomes at 3 and 6 months
post-therapy. Further investigation is needed to evaluate variables such as
different photosensitiser concentrations and adjusting parameters associated with
the light source.
AN - rayyan-563562285
AU - Bashir, N. Z.
AU - Singh, H. A.
AU - Virdee, S. S.
DO - 10.1007/s00784-021-03871-2
IS - 10
PY - 2021
SN - ["1432-6981", "1436-3771"]
SP - 5699-5710
ST - Indocyanine green-mediated antimicrobial photodynamic therapy as an adjunct
to periodontal therapy: a systematic review and meta-analysis
T2 - CLINICAL ORAL INVESTIGATIONS
TI - Indocyanine green-mediated antimicrobial photodynamic therapy as an adjunct
to periodontal therapy: a systematic review and meta-analysis
VL - 25
Y2 - 10
ID - 15659
ER -
TY - JOUR
AB - Among the chronic non-communicable degenerative diseases (CDNCDs), chronic
kidney disease (CKD) represents a global public health problem. Recent studies
demonstrate a mutual cause-effect relationship between CKD and oral diseases, in
which the presence of one induces the onset and faster progression of the other. In
particular, the oral cavity alterations more frequent in CKD patients are: chronic
periodontitis diseases, bone lesions, oral infections, and oral cancer lesions.
Currently, a standardized therapy for the treatment of oral diseases is lacking.
For this reason, natural bioactive compounds (NBCs), characterized by several
health effects, such as antioxidant, antimicrobial, anti-inflammatory and anti-
cancer actions, represent a new possible adjuvant therapy in the management of
these pathological conditions. Among NBCs, polyphenols play a leading role due to
positive modulation of oral microbiota, preventing and correcting oral dysbiosis.
Moreover, these compounds exert anti-inflammatory effects, such as inhibiting the
production of pro-inflammatory cytokines and the expression of cycloxigenase-2. In
this light, the formulation of a new mouthwash/gel/gingival paste, with a high
content of polyphenols in association with NBCs characterized by antimicrobial
action, could represent a future therapy of oral disease in CKD patients.
AN - rayyan-563560832
AU - Basilicata, M.
AU - Di Lauro, M.
AU - Campolattano, V.
AU - Marrone, G.
AU - Celotto, R.
AU - Mitterhofer, A. P.
AU - Bollero, P.
AU - Di Daniele, N.
AU - Noce, A.
DO - 10.3390/ijerph19031665
IS - 3
J2 - Int J Environ Res Public Health
KW - Anti-Inflammatory Agents
Dysbiosis
Humans
*Mouth Diseases/drug therapy
*Periodontitis
*Renal Insufficiency, Chronic/drug therapy
LA - eng
N1 - UOSD Special Care Dentistry, Department of Experimental Medicine and Surgery,
University of Rome Tor Vergata, 00100 Rome, Italy.; UOC of Internal Medicine-Center
of Hypertension and Nephrology Unit, Department of Systems Medicine, University of
Rome Tor Vergata, 00133 Rome, Italy.; UOSD Special Care Dentistry, Department of
Dentistry and Dental Prosthesis, University of Rome Tor Vergata, 00133 Rome,
Italy.; UOC of Internal Medicine-Center of Hypertension and Nephrology Unit,
Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.;
Department of Cardiovascular Disease, University of Rome Tor Vergata, 00133 Rome,
Italy.; Nephrology and Dialysis Unit, Department of Systems Medicine, University of
Rome Tor Vergata, 00133 Rome, Italy.; UOSD Special Care Dentistry, Department of
Systems Medicine, University of Rome Tor Vergata, 00100 Rome, Italy.; UOC of
Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems
Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.; UOC of Internal
Medicine-Center of Hypertension and Nephrology Unit, Department of Systems
Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
PY - 2022
ST - Natural Bioactive Compounds in the Management of Oral Diseases in
Nephropathic Patients
T2 - International journal of environmental research and public health
TI - Natural Bioactive Compounds in the Management of Oral Diseases in
VL - 19
Y2 - 1 y3 - 31
ID - 14206
ER -
TY - JOUR
AB - Among the chronic non-communicable degenerative diseases (CDNCDs), chronic
kidney disease (CKD) represents a global public health problem. Recent studies
demonstrate a mutual cause–effect relationship between CKD and oral diseases, in
which the presence of one induces the onset and faster progression of the other. In
particular, the oral cavity alterations more frequent in CKD patients are: Chronic
periodontitis diseases, bone lesions, oral infections, and oral cancer lesions.
Currently, a standardized therapy for the treatment of oral diseases is lacking.
For this reason, natural bioactive compounds (NBCs), characterized by several
health effects, such as antioxidant, antimicrobial, anti-inflammatory and anti-
cancer actions, represent a new possible adjuvant therapy in the management of
these pathological conditions. Among NBCs, polyphenols play a leading role due to
positive modulation of oral microbiota, preventing and correcting oral dysbiosis.
Moreover, these compounds exert anti-inflammatory effects, such as inhibiting the
production of pro-inflammatory cytokines and the expression of cycloxigenase-2. In
this light, the formulation of a new mouthwash/gel/gingival paste, with a high
content of polyphenols in association with NBCs characterized by antimicrobial
action, could represent a future therapy of oral disease in CKD patients.
AN - rayyan-563559901
AU - Basilicata, M.
AU - Lauro, M. D.
AU - Campolattano, V.
AU - Marrone, G.
AU - Celotto, R.
AU - Mitterhofer, A. P.
AU - Bollero, P.
AU - Daniele, N. D.
AU - Noce, A.
DO - 10.3390/ijerph19031665
IS - 3
KW - cyclooxygenase 2
mouthwash
natural product
polyphenol
chronic kidney failure
comorbidity
cytokine production
dental health
dentistry
dysbiosis
graft recipient
hemodialysis patient
human
kidney graft
mouth disease
mouth flora
mouth tissue
nonhuman
prophylaxis
protein expression
renal replacement therapy
review
saliva
tooth tissue
LA - English
PY - 2022
SN - ["1660-4601", "1661-7827"]
ST - Natural Bioactive Compounds in the Management of Oral Diseases in
T2 - Int. J. Environ. Res. Public Health
TI - Natural Bioactive Compounds in the Management of Oral Diseases in
VL - 19
ID - 13275
ER -
TY - JOUR
AB - Objective. We sought to assess the efficacy of chlorhexidine (CHX) and
calcium hydroxide, Ca(OH)(2), against Enterococcus faecalis in vitro. Study design.
The effect of CHX (0.2% and 2% in gel or solution) and Ca(OH), (alone or with 0.2%
CHX gel) was evaluated by using the agar diffusion test and an in vitro human root
inoculation method, to measure zone of inhibition or bacterial growth with optical
density analysis, respectively. For optical density analysis, samples from infected
root canals were collected after 7 days of medication and were cultured for 24
hours in brain-heart infusion to detect viable bacteria. Results. In the agar
diffusion test, CHX was effective against E faecalis in a concentration-dependent
fashion, but Ca(OH)(2) alone had no effect. In the root canal inoculation test, CHX
was significantly more effective against E faecalis than Ca(OH)(2) was (P <.05),
but there were no significant differences between the modes of medication or
concentrations of CHX. Conclusions. CHX is effective against E faecalis in vitro.
Further in vivo studies are needed to confirm the value of CHX in clinical
treatment.
AN - rayyan-563562631
AU - Basrani, B.
AU - Tjaderhane, L.
AU - Santos, J. M.
AU - Pascon, E.
AU - Grad, H.
AU - Lawrence, H. P.
AU - Friedman, S.
DO - 10.1016/S1079-2104(03)00166-5
IS - 5
PY - 2003
SN - ["1079-2104", "1528-395X"]
SP - 618-624
ST - Efficacy of chlorhexidine- and calcium hydroxide-containing medicaments
against Enterococcus faecalis in vitro
T2 - ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
TI - Efficacy of chlorhexidine- and calcium hydroxide-containing medicaments
against Enterococcus faecalis in vitro
VL - 96
Y2 - 11
ID - 16005
ER -
TY - JOUR
AN - rayyan-563561213
AU - Bassiouny, M. A.
AU - Grant, A. A.
IS - 8
KW - biguanide derivative
chlorhexidine
placebo
toothpaste
adult
aged
article
chemically induced disorder
clinical trial
female
gel
gingivitis
human
male
middle aged
tooth brushing
tooth calculus
tooth discoloration
tooth plaque
LA - English
PY - 1975
SN - 0007-0610
SP - 323-327
ST - The toothbrush application of chlorhexidine. A clinical trial
T2 - Br Dent J
TI - The toothbrush application of chlorhexidine. A clinical trial
VL - 139
ID - 14587
ER -
TY - JOUR
AB - Background and Aim: Periodontitis is characterized by deep periodontal
pockets associated with dysbiotic flora and hypoxic microenvironment that
exacerbates inflammation and tissue degradation. Arenicola marina's hemoglobin
(M101) has an excellent oxygen carrying potential and antioxidant capacity and,
recently, has demonstrated anti-inflammatory and anti-bacterial properties. The aim
of this study was to evaluate the role of M101 in reducing hypoxia and oxidative
stress in vitro and in vivo. Methods: In vitro, Oral epithelial cells (EC) in 2D
and 3D culture were infected with P. gingivalis (MOI = 100) or exposed to cobalt
chloride CoCl2 at 1000 μM to induce hypoxia and oxidative stress, and treated with
M101 (1 g/L) for 24 h. Hypoxia was evaluated using fluorescence microscopy and
quantification of the expression of key hypoxia markers HIF-1α, Glut-1, Glut-3
through RT-qPCR and Western Blot. In vivo, experimental periodontitis was induced
for 3 weeks and lesions were treated with M101 hydrogel application. Healing was
assessed by histomorphometric analysis and TRAP staining 3 weeks post-treatment.
Immunofluorescence studies were carried out on the histological samples to assess
the expression of hypoxia and associated tissue degradative factors such as HIF-1α,
nuclear factor kappa-B (NF-κB) and matrix metalloproteinase-9 (MMP-9). Results: In
EC, M101 (1 g/L) treatment reduced P. gingivalis and cobalt chloride induced-
hypoxia and oxidative stress. After 6 h of treatment, the relative gene expression
of key hypoxia markers induced by P. gingivalis and CoCl2 (HIF-1α, Glut-1, Glut-3)
was decreased by 1.6 folds, 2 folds and 1.5 folds respectively (p < 0.05). In vivo,
histomorphometric analyses showed improved clinical attachment (p < 0.05) and
reduced osteoclastic activity in mice treated with M101 gels versus untreated
controls. Immunofluorescence analysis also revealed decreased HIF-1α, NF-κB and
MMP-9 expression in periodontal tissues of M101 treated groups. Conclusions: M101
is a highly promising molecule capable of ameliorating hypoxia triggered
inflammation and tissue degradation induced by P. gingivalis. Therefore, it
presents a significant therapeutic potential in the management of periodontitis.
AN - rayyan-563559847
AU - Batool, F.
AU - Petit, C.
AU - Stutz, C.
AU - Özçcelik, H.
AU - Delpy, E.
AU - Zal, F.
AU - Leize-Zal, E.
AU - Huck, O.
DO - 10.1111/jcpe.13636
KW - cobalt chloride
endogenous compound
gelatinase B
glucose transporter 1
hemoglobin S
hydrogel
hypoxia inducible factor 1alpha
animal cell
animal experiment
animal model
Arenicola marina
cell culture
conference abstract
controlled study
epithelium cell
gene expression
histopathology
hypoxia
immunofluorescence
in vitro study
in vivo study
inflammation
male
mouse
nonhuman
osteoclast activity
oxidative stress
periodontitis
periodontium
protein expression
Western blotting
LA - English
PY - 2022
SN - 1600-051X
SP - 231-232
ST - Arenicola marina's haemoglobin (M101) reduces P. gingivalis induced
inflammation and hypoxia in vitro and in vivo
TI - Arenicola marina's haemoglobin (M101) reduces P. gingivalis induced
inflammation and hypoxia in vitro and in vivo
VL - 49
ID - 13221
ER -
TY - JOUR
AB - PURPOSE: To evaluate the effects of fluoride varnish vs a combination of
chlorhexidine-thymol varnish plus a gel containing chlorhexidine and fluoride on
oral hygiene and caries prevention in disabled children. MATERIALS AND METHODS:
Ninety patients aged 3-17 years who were treated under general anaesthesia were
randomly assigned into three groups as follows: group 1: Fluor Protector (0.1%
fluoride varnish); group 2: Cervitec Plus (1% chlorhexidine- 1% thymol varnish) +
Cervitec Gel (0.2% chlorhexidine-0.2% sodium fluoride); group 3: control
(toothbrushing only). Mutans streptococci (MS) and lactobacilli (LB) levels,
visible plaque index (VPI) and gingival bleeding index (GBI) were evaluated at four
stages: T0, before general anaesthesia; T1, one month after treatment; T2, six
months after treatment; T3, twelve months after treatment. The data were evaluated
using Kruskal-Wallis and Mann-Whitney U-tests (P < 0.05). RESULTS: Groups 1 and 2
showed significantly lower scores than group 3 for all parameters at T1 and T2. No
statistically significant difference was detected among any of the the groups at T3
(P > 0.05). CONCLUSION: The use of materials that include both fluoride and
chlorhexidine as routine treatment of children with disability may increase the
success of restorations by improving oral hygiene, reduce the need for future
restorative treatments and thus the need for general anaesthesia.
AN - rayyan-563560458
AU - Baygin, O.
AU - Tuzuner, T.
AU - Kusgoz, A.
AU - Senel, A. C.
AU - Tanriver, M.
AU - Arslan, I.
DO - 10.3290/j.ohpd.a32129
IS - 4
antiinfective agent
chlorhexidine
chlorhexidine, thymol drug combination
drug combination
Fluor Protector
fluoride varnish
polyurethan
silane derivative
thymol
toothpaste
adolescent
bacterial load
child
comparative study
controlled study
dental caries
tooth plaque
dental procedure
drug effect
female
follow up
gingivitis
disabled child
human
Lactobacillus
male
microbiology
mouth hygiene
periodontics
preschool child
procedures
saliva
tooth brushing
LA - English
PY - 2014
SN - 1602-1622
SP - 373-382
ST - Antibacterial effects of fluoride varnish compared with chlorhexidine plus
fluoride in disabled children
T2 - Oral Health Prev Dent
TI - Antibacterial effects of fluoride varnish compared with chlorhexidine plus
VL - 12
ID - 13832
ER -
TY - COMP
AB - PURPOSE: To evaluate the effects of fluoride varnish vs a combination of
chlorhexidine-thymol varnish plus a gel containing chlorhexidine and fluoride on
oral hygiene and caries prevention in disabled children. MATERIALS AND METHODS:
Ninety patients aged 3-17 years who were treated under general anaesthesia were
randomly assigned into three groups as follows: group 1: Fluor Protector (0.1%
fluoride varnish); group 2: Cervitec Plus (1% chlorhexidine- 1% thymol varnish) +
Cervitec Gel (0.2% chlorhexidine-0.2% sodium fluoride); group 3: control
(toothbrushing only). Mutans streptococci (MS) and lactobacilli (LB) levels,
visible plaque index (VPI) and gingival bleeding index (GBI) were evaluated at four
stages: T0, before general anaesthesia; T1, one month after treatment; T2, six
months after treatment; T3, twelve months after treatment. The data were evaluated
using Kruskal-Wallis and Mann-Whitney U-tests (P < 0.05). RESULTS: Groups 1 and 2
showed significantly lower scores than group 3 for all parameters at T1 and T2. No
statistically significant difference was detected among any of the the groups at T3
(P > 0.05). CONCLUSION: The use of materials that include both fluoride and
chlorhexidine as routine treatment of children with disability may increase the
success of restorations by improving oral hygiene, reduce the need for future
restorative treatments and thus the need for general anaesthesia.
AN - rayyan-563561402
AU - Baygin, O.
AU - Tuzuner, T.
AU - Kusgoz, A.
AU - Senel, A. C.
AU - Tanriver, M.
AU - Arslan, I.
CY - Germany
DO - 10.3290/j.ohpd.a32129
ET - 4
J2 - Oral Health Prev Dent
KW - Adolescent
Anti-Bacterial Agents/*therapeutic use
Anti-Infective Agents, Local/*therapeutic use
Cariostatic Agents/*therapeutic use
Child
Child, Preschool
Chlorhexidine/*therapeutic use
Dental Care for Disabled
Dental Caries/prevention & control
Dental Plaque/prevention & control
Dental Plaque Index
Dentifrices/therapeutic use
*Disabled Children
Drug Combinations
Female
Fluorides, Topical/*therapeutic use
Follow-Up Studies
Gingivitis/prevention & control
Humans
Lactobacillus/drug effects
Male
Oral Hygiene
Periodontal Index
Polyurethanes/*therapeutic use
Saliva/microbiology
Silanes/*therapeutic use
Streptococcus mutans/drug effects
Thymol/*therapeutic use
Toothbrushing/methods
LA - eng
PY - 2014
SN - 1602-1622 (Print)
SP - 373-82
ST - Antibacterial effects of fluoride varnish compared with chlorhexidine plus
T2 - Oral health & preventive dentistry
TI - Antibacterial effects of fluoride varnish compared with chlorhexidine plus
VL - 12
ID - 14776
ER -
TY - JOUR
AB - This case report describes the use synthetic bone graft particulate and 24%
EDTA gel to treat an infrabony defect adjacent to the mandibular right first molar
tooth in an American Eskimo dog. Postoperative examination 33-months following
surgery showed osseous integration at the infrabony defect and restoration of the
periodontal ligament space with a small refractory periodontal pocket.
AN - rayyan-563560857
AU - Beckman, B. W.
DO - 10.1177/089875640402100303
IS - 3
KW - ampicillin
butorphanol
carprofen
clavulanic acid
diazepam
edetic acid
isoflurane
ketamine
ketoprofen
oxygen
article
bone graft
dog
female
follow up
health
mandible reconstruction
molar tooth
mouth examination
nonhuman
periodontics
postoperative analgesia
valium
LA - English
PY - 2004
SN - 0898-7564
SP - 159-163
ST - Treatment of an infrabony pocket in an American eskimo dog
T2 - J. Vet. Dent.
TI - Treatment of an infrabony pocket in an American eskimo dog
VL - 21
ID - 14231
ER -
TY - JOUR
AB - The objectives of the present research work were systematic development of
novel in situ gel formulation containing nanoparticles for localised delivery of
moxifloxacin against bacterial periodontitis. PLGA nanoparticles were prepared and
optimised in a systematic manner. Factor screening was performed with the help of
half-factorial design to identify the influential factors, while response surface
optimisation of the nanoparticles was conducted using central composite design. The
optimum nanoparticle formulation was chosen on the basis of lower particle size,
higher drug entrapment and controlled drug release characteristics up to 1 week
time period, while the optimum in situ gel was selected on the basis of faster
gelling and higher viscosity and gel strength properties for improved retention in
the periodontium. In vivo histopathological studies and in vivo gamma scintigraphy
studies revealed the extended release, superior efficacy and enhanced retention of
nanoparticle-loaded in situ gelling system. Results obtained from in vivo
histopathological studies after 1 week treatment with in situ gel formulation
containing nanoparticles of moxifloxacin were found to be better than with 3 weeks
treatment of marketed gel formulation. Overall, the studies ratify successful
development of an effective site-specific drug delivery system with enhanced
biopharmaceutical attributes for the periodontitis treatment.
AN - rayyan-563560126
AU - Beg, S.
AU - Dhiman, S.
AU - Sharma, T.
AU - Jain, A.
AU - Sharma, R. K.
AU - Singh, B.
DO - 10.1208/s12249-019-1613-7
IS - 3
KW - moxifloxacin
nanoparticle
poloxamer
polyglactin
alveolar bone
animal experiment
article
buccal mucosa
controlled study
drug formulation
drug screening
gamma scintigraphy
histopathology
in vivo study
male
nanopharmaceutics
nonhuman
osteoclast
osteolysis
particle size
periodontitis
periodontium
priority journal
surface property
viscosity
zeta potential
LA - English
PY - 2020
SN - 1530-9932
ST - Stimuli Responsive In Situ Gelling Systems Loaded with PLGA Nanoparticles of
Moxifloxacin Hydrochloride for Effective Treatment of Periodontitis
TI - Stimuli Responsive In Situ Gelling Systems Loaded with PLGA Nanoparticles of
Moxifloxacin Hydrochloride for Effective Treatment of Periodontitis
VL - 21
ID - 13500
ER -
TY - JOUR
AB - Objective: The aim of this study is to clarify the association between
diabetes mellitus and periodontitis and assess the effect of metronidazole and
chlorhexidine mixture as a local delivery. Subjects and Methods: Sixty patients
constituted three groups: (i) Type 2 diabetes with advanced periodontitis; (ii)
diabetes mellitus without periodontitis; and (iii) periodontitis without diabetes.
Clinical attachment loss (CAL) and bleeding index (BI) were recorded. Periodontitis
received first non-surgical therapy, and then metronidazole and chlorhexidine gel.
Diabetics undertook blood analysis for diabetic factors. Results: Statistical
differences were noticed between Groups I and II at all periods (3 and 6 months)
except few sites, and between Groups I and III at all sites of CAL and most sites
of BI. Group I had the worst measurements at baseline and 3 months which reversed
with less measurements at 6 months (following therapy) by demonstrating significant
intergroup positive changes, without significance prior to therapy. No significant
differences were noticed within Groups I and III for CAL prior to therapy except
few sites, but were present at 6 months at all sites in Group III and except two
sites in Group I for BI, no differences were noticed except three sites.
Conclusion: The present study suggested evidence on improvement of periodontal
parameters following treatment with the local mixture of metronidazole and
chlorhexidine gel.
AN - rayyan-563560403
AU - Belal, M. H.
AU - Yassin, A.
DO - 10.5455/jeim.120415.or.126
IS - 2
KW - chlorhexidine
glucose
hemoglobin A1c
metronidazole
adult
article
controlled study
disease association
disease severity
female
human
male
medical parameters
papillary bleeding index
periodontal disease
LA - English
PY - 2015
SN - ["2146-3298", "1309-4572"]
SP - 93-99
ST - Type 2 diabetes mellitus and severe periodontal disease in an adult
population; Effect of a new local delivery approach
T2 - J. Exp. Integr. Med.
TI - Type 2 diabetes mellitus and severe periodontal disease in an adult
population; Effect of a new local delivery approach
VL - 5
ID - 13777
ER -
TY - JOUR
AB - Aggregatibacter actinomycetemcomitans is a periodontal pathogen colonizing
the oral cavity of a large proportion of the human population. It is equipped with
several potent virulence factors that can cause cell death and induce or evade
inflammation. Because of the large genetic diversity within the species, both
harmless and highly virulent genotypes of the bacterium have emerged. The oral
condition and age, as well as the geographic origin of the individual, influence
the risk to be colonized by a virulent genotype of the bacterium. In the present
review, the virulence and pathogenicity properties of A. actinomycetemcomitans will
be addressed.
AN - rayyan-563560166
AU - Belibasakis, G. N.
AU - Maula, T.
AU - Bao, K.
AU - Lindholm, M.
AU - Bostanci, N.
AU - Oscarsson, J.
AU - Ihalin, R.
AU - Johansson, A.
DO - 10.3390/pathogens8040222
IS - 4
KW - fluorescence microscope
mass spectrometer
bacterial protein
bacterium lipopolysaccharide
CD18 antigen
cytolethal distending toxin
gamma interferon
inflammasome
interleukin 1beta
interleukin 6
interleukin 8
leukotoxin
lymphocyte function associated antigen 1
amino acid repeat
apoptosis
bacterial virulence
bacterium culture
biofilm
biomass production
cell cycle arrest
cytokine production
disease exacerbation
DNA damage
environmental factor
genetic variability
genotype
horizontal gene transfer
human
immunofluorescence microscopy
nonhuman
periodontitis
protein localization
proteomics
review
stereochemistry
tandem repeat
toxicity testing
two dimensional difference gel electrophoresis
LA - English
PY - 2019
SN - 2076-0817
ST - Virulence and pathogenicity properties of Aggregatibacter
actinomycetemcomitans
T2 - Pathogens
TI - Virulence and pathogenicity properties of Aggregatibacter
VL - 8
ID - 13540
ER -
TY - JOUR
AB - Introduction: Chlorhexidine (CHX) oral topical application has been
extensively used for preventing respiratory tract infections among critical
patients, despite controversial effectiveness demonstrated in different clinical
trials. More recently, this practice has been found suspect of enhancing mortality
in hospitalized patients, for reasons not clearly understood. Acute Respiratory
Distress Syndrome (ARDS) was hypothesized as a pathway for this association.
Objectives: To reassess data from a clinical trial evaluating oral care in the
intensive care unit (ICU), in order to search for potential pathways for the CHX-
associated mortality. Methods: This is a post-hoc analysis of a randomized clinical
trial (RBR-89CP93) evaluating a dental care intervention aimed to prevent
respiratory tract infections in the ICU setting, funded by two non-profit
foundations (FAPESP and FAEPA). We analyzed data from adult patients who were
assigned to receive dental care provided by a dentist (experimental group) or
routine oral care provided by the nursing staff (control group). Both groups used
0.12% CHX oral solution, if fully conscious, or 2% CHX oral gel, if unconscious,
three times a day throughout their ICU stay. Adverse events potentially related to
CHX use were reassessed and their relationship with in-ICU death was evaluated
through a logistic regression model. Results: Among the 254 patients included, 18
(7.09%) developed CHX-induced oral mucositis, which was independently associated
with age (OR=1.05; 95%CI: 1.02-1.09) and the intervention (OR= 6.53; 95%CI: 1.74-
24.48), and inversely associated with being edentulous (OR=0.09; 95%CI: 0.02-0.45).
On the other hand, CHX-induced oral mucositis was an independent risk factor for
death (OR= 5.62; 95%CI: 1.94-16.25) and death due to respiratory tract infections
(OR=3.27; 95%CI: 1.18-9.08). No death due to ARDS was reported. Conclusion: CHX-
induced oral mucositis was found to be a relevant risk factor for death in this
clinical trial and may be a clinical pathway explaining why CHX enhances mortality
among critical patients. Intensivists should be very cautious when prescribing CHX
for critical patients and should immediately suspend it when any sign of oral
mucositis is observed.
AN - rayyan-563560223
AU - Bellissimo-Rodrigues, W. T.
AU - Menegueti, M. G.
AU - Mussolin, M. G.
AU - MacEdo, L. D.
AU - Basile-Filho, A.
AU - Martinez, R.
AU - Souza, J. P.
AU - Bellissimo-Rodrigues, F.
DO - 10.1186/s13756-019-0567-6
KW - chlorhexidine
adult
adult respiratory distress syndrome
adverse drug reaction
age
conference abstract
controlled study
dental procedure
dentist
drug therapy
ego development
female
human
intensive care unit
intensivist
male
mortality
mouth hygiene
nursing staff
oral mucositis
periodontal disease
post hoc analysis
prescription
prevention
respiratory tract infection
risk factor
side effect
LA - English
PY - 2019
SN - 2047-2994
ST - Chlorhexidine oral topical application for critical patients: Savior or
killer?
T2 - Antimicrob. Resist. Infect. Control
TI - Chlorhexidine oral topical application for critical patients: Savior or
killer?
VL - 8
ID - 13597
ER -
TY - JOUR
AB - In a short-term longitudinal study the authors intended to compare the
effectiveness in controlling plaque formation and gingival inflammation of a 1%
chlorhexidine gel to the one of a 0.2% chlorhexidine solution. The gel, used once a
day, resulted as good as the chlorhexidine solution, but showed a localized
activity.
AN - rayyan-563561175
AU - Benigni, A.
AU - Paolantonio, M.
AU - Di Murro, C.
AU - Cattabriga, M.
IS - 4
KW - chlorhexidine
adult
article
comparative study
gel
gingivitis
human
longitudinal study
male
mouth hygiene
tooth plaque
LA - Italian
PY - 1989
SN - 0393-9960
SP - 9-15
ST - Efficacy of chlorhexidine as a gel and as a mouthwash
T2 - L'efficacia della clorexidina sotto forma di gel e di collutorio.
TI - Efficacy of chlorhexidine as a gel and as a mouthwash
VL - 15
ID - 14549
ER -
TY - JOUR
AB - To assess the efficacy of curcumin gel in the treatment of periodontal
disease. The curcumin gel reduces microbes and improves the efficacy in the
treatment of periodontal diseases. Complete removal of irritants is not possible
with mechanical therapy alone. Mechanical therapy when combined with local delivery
systems such as the curcumin gel reduces microbes and improves clinical parameters.
Curcumin a constituent of Curcuma longa plant, which possess antioxidant, anti-
inflammatory, anti-carcinogenic, anti-microbial, anti-hyper and hypo
cholesterolemic properties Curcumin gel is given for the treatment of periodontal
diseases. This study shows that the curcumin gel which is used as an adjunct showed
better results due to its anti inflammatory properties. Curcumin gel can be used an
adjunct to local drug delivery agent. However, further studies on large population
using varied concentrations of drug may be required to improve the substantivity of
the drug.
AN - rayyan-563560330
AU - Benly, P.
AU - Jaiganesh
IS - 6
KW - curcumin
article
clinical article
clinical trial
dental scaling
drug efficacy
gel
gingival index
human
periodontal disease
LA - English
PY - 2016
SN - 0975-8585
SP - 1561-1565
ST - Effect of curcumin gel in the treatment of periodontal disease: A clinical
trial
T2 - Res. J. Pharm., Biol. Chem. Sci.
TI - Effect of curcumin gel in the treatment of periodontal disease: A clinical
trial
VL - 7
ID - 13704
ER -
TY - JOUR
AB - Immune homeostasis is maintained by a precise balance between effector immune
cells and regulatory immune cells. Chronic deviations from immune homeostasis,
driven by a greater ratio of effector to regulatory cues, can promote the
development and propagation of inflammatory diseases/conditions (i.e., autoimmune
diseases, transplant rejection, etc.). Current methods to treat chronic
inflammation rely upon systemic administration of non-specific small molecules,
resulting in broad immunosuppression with unwanted side effects. Consequently,
recent studies have developed more localized and specific immunomodulatory
approaches to treat inflammation through the use of local biomaterial-based
delivery systems. In particular, this review focuses on (1) local biomaterial-based
delivery systems, (2) common materials used for polymeric-delivery systems and (3)
emerging immunomodulatory trends used to treat inflammation with increased
specificity.
AN - rayyan-563559947
AU - Bentley, E. R.
AU - Little, S. R.
DO - 10.1016/j.addr.2021.113971
KW - agarose
alginic acid
betamethasone
biomaterial
celecoxib
chitosan
collagen
cyclosporine
dexamethasone
diclofenac
everolimus
gelatin
hyaluronic acid
hydrogel
immunomodulating agent
indometacin
macrogol
methotrexate
molecular scaffold
mometasone furoate
poloxamer
poly(n isopropylacrylamide)
polyacrylamide
polycaprolactone
polyester
polyether
polyglactin
polylysine
prednisolone
silk fibroin
sirolimus
tacrolimus
temsirolimus
triamcinolone acetonide
autoimmune disease
autoimmunity
chronic inflammation
chronic rhinosinusitis
graft rejection
homeostasis
human
immunity
immunocompetent cell
immunomodulation
immunosuppressive treatment
inflammatory bowel disease
insulin dependent diabetes mellitus
multiple sclerosis
nonhuman
periodontal disease
periodontitis
review
Sjoegren syndrome
LA - English
PY - 2021
SN - ["1872-8294", "0169-409X"]
ST - Local delivery strategies to restore immune homeostasis in the context of
inflammation
T2 - Adv. Drug Deliv. Rev.
TI - Local delivery strategies to restore immune homeostasis in the context of
inflammation
VL - 178
ID - 13321
ER -
TY - JOUR
AB - BACKGROUND AND OBJECTIVE: The evidence of effectiveness of metronidazole
(Mtz) as an adjunct therapy to periodontal procedure in the treatment of patients
with chronic periodontitis is not conclusive. The aim of this study was to compare
the effect of Mtz (delivered locally as a gel or systemically as a tablet) as an
adjunctive therapy with full mouth periodontal debridement (1 h of ultrasonic
calculus/plaque removal) in smokers with chronic periodontitis. MATERIAL AND
METHODS: This pilot study involved 30 smokers with at least six teeth with a
clinical attachment loss of ≥ 5 mm and probing pocket depth (PPD) of ≥ 5 mm. They
were randomly assigned into one of three groups (n = 10): (i) 3 g daily of placebo
gel applied topically (using a dental tray with the gel overnight) + periodontal
debridement; (ii) 3 g daily of a 15% Mtz benzoate gel applied topically (using a
dental tray with the gel overnight) + periodontal debridement; and (iii) a daily
single dose of 750 mg Mtz (Flagyl(®)) + periodontal debridement. Clinical
parameters (visible plaque index, gingival bleeding index [GBI], relative
attachment level and PPD) and quantitative analysis (by real-time polymerase chain
reaction) of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and
Tannerella forsythia were assessed at baseline and at 1, 3 and 6 mo after
periodontal debridement. RESULTS: There was no statistically significant difference
in the average GBI and visible plaque index values at baseline between the groups
(p ≥ 0.05). There was no significant difference between groups in all parameters
evaluated (p ≥ 0.05). Significant reductions in GBI at 3 and 6 mo were observed in
all groups (p < 0.05). Significant reductions in both PPD and relative attachment
level at 1, 3 and 6 mo were observed in all groups (p < 0.05). Significant
reductions in bacterial levels at 7 and 30 d were observed in all groups (p <
0.05). CONCLUSION: Adjunctive use of Mtz (gel or tablet) to periodontal debridement
had similar clinical and microbiological improvement compared to treatment with
placebo + periodontal debridement in smokers with chronic periodontitis up to 6 mo
post-treatment. Further studies are necessary to confirm the clinical relevance of
these findings.
AN - rayyan-563560357
AU - Bergamaschi, C. C.
AU - Santamaria, M. P.
AU - Berto, L. A.
AU - Cogo-Müller, K.
AU - Motta, R. H.
AU - Salum, E. A.
AU - Nociti Júnior, F. H.
AU - Goodson, J. M.
AU - Groppo, F. C.
DO - 10.1111/jre.12278
IS - 1
KW - metronidazole
controlled study
dental debridement
dental scaling
follow up
human
periodontal disease
periodontal index
periodontal pocket
pilot study
smoking
LA - English
PY - 2016
SN - 1600-0765
SP - 50-59
ST - Full mouth periodontal debridement with or without adjunctive metronidazole
gel in smoking patients with chronic periodontitis: A pilot study
TI - Full mouth periodontal debridement with or without adjunctive metronidazole
gel in smoking patients with chronic periodontitis: A pilot study
VL - 51
ID - 13731
ER -
TY - JOUR
AN - rayyan-563561207
AU - Bergstrom, J.
AU - Dyrssen, N. G.
AU - Hellstrom, P.
IS - 4
KW - chlorhexidine
periodontal disease
therapy
tooth plaque
LA - English
PY - 1976
SP - 105-108
ST - A clinical study of the anti plaque capacity of chlorhexidine gel
T2 - SVEN. TANDLAK. TIDSKR.
TI - A clinical study of the anti plaque capacity of chlorhexidine gel
VL - 69
ID - 14581
ER -
TY - JOUR
AB - Decapeptide KSL-W shows antibacterial activities and can be used in the oral
cavity, however, it is easily degraded in aqueous solution and eliminated.
Therefore, we aimed to develop liquid crystalline systems (F1 and F2) for KSL-W
buccal administration to treat multispecies oral biofilms. The systems were
prepared with oleic acid, polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol
(PPG-5-CETETH-20), and a 1% poloxamer 407 dispersion as the oil phase (OP),
surfactant (S), and aqueous phase (AP), respectively. We characterized them using
polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), rheology,
and in vitro bioadhesion, and performed in vitro biological analysis. PLM showed
isotropy (F1) or anisotropy with lamellar mesophases (F2), confirmed by peak ratio
quantification using SAXS. Rheological tests demonstrated that F1 exhibited
Newtonian behavior but not F2, which showed a structured AP concentration-dependent
system. Bioadhesion studies revealed an AP concentration-dependent increase in the
system's bioadhesiveness (F2 = 15.50 +/- 1.00 mNs) to bovine teeth blocks.
Antimicrobial testing revealed 100% inhibition of multispecies oral biofilm growth
after KSL-W administration, which was incorporated in the F2 aqueous phase at a
concentration of 1 mg/mL. Our results suggest that this system could serve as a
potential vehicle for buccal administration of antibiofilm peptides.
AN - rayyan-563562560
AU - Bernegossi, J.
AU - Calixto, G. M. F.
AU - Sanches, P. R. D.
AU - Fontana, C. R.
AU - Cilli, E. M.
AU - Garrido, S. S.
AU - Chorilli, M.
DO - 10.3390/molecules21010037
IS - 1
PY - 2016
SN - 1420-3049
ST - Peptide KSL-W-Loaded Mucoadhesive Liquid Crystalline Vehicle as an
Alternative Treatment for Multispecies Oral Biofilm
T2 - MOLECULES
TI - Peptide KSL-W-Loaded Mucoadhesive Liquid Crystalline Vehicle as an
Alternative Treatment for Multispecies Oral Biofilm
VL - 21
Y2 - 1
ID - 15934
ER -
TY - JOUR
AB - OBJECTIVE: This randomized clinical trial evaluated the effect of 35%
hydrogen peroxide in comparison with 37% carbamide peroxide in a nonvital bleaching
technique of "walking bleaching" (four sessions of treatment) on periodontal
markers: nuclear factor kappa B-ligand (RANK-L-process of root resorption marker)
and interleukin 1β (IL-1β-inflammatory response marker). METHODS AND MATERIALS:
Fifty volunteers presenting with discoloration of nonvital teeth and endodontic
treatment in good condition participated. Fifty teeth were randomly divided into
two study groups according to bleaching gel: HP = 35% hydrogen peroxide (n=25) and
37% carbamide peroxide (n=25). Nonvital bleaching was performed with a walking
bleaching technique consisting of four sessions of bleach application. Gingival
crevicular fluid samples were taken in order to quantify the RANK-L and IL-1β
levels by enzyme-linked immunosorbent assay. Samples were obtained from six
periodontal sites for each bleached tooth: three vestibular and three palatine
(mesial, middle, and distal) at seven time periods: baseline, after each of the
four sessions of nonvital bleaching, at one week, and at one month after nonvital
bleaching. Tooth color variations were analyzed in each session by VITA
Bleachedguide 3D-MASTER (ΔSGU). RESULTS: Significant increments in the RANK-L and
IL-1β levels were detected in each evaluated time compared with baseline ( p<0.05);
however, no differences were detected between hydrogen peroxide and carbamide
peroxide on increments of the biomarkers studied. The change of color was effective
for both nonvital bleaching therapies ( p<0.05). CONCLUSIONS: Nonvital bleaching
induced a significant increment in the RANK-L and IL-1β levels in periodontal
tissues around bleached, nonvital teeth.
AN - rayyan-563560258
AU - Bersezio, C.
AU - Vildósola, P.
AU - Sáez, M.
AU - Sánchez, F.
AU - Vernal, R.
AU - Oliveira, O. B.
AU - Jorquera, G.
AU - Basualdo, J.
AU - Loguercio, A.
AU - Fernández, E.
DO - 10.2341/16-334-C
IS - 3
KW - biological marker
carbamide peroxide
hydrogen peroxide
interleukin 1beta
osteoclast differentiation factor
peroxide
TNFSF11 protein, human
urea
adult
aged
analogs and derivatives
chemically induced
chemistry
controlled study
dental procedure
female
gingivitis
human
male
middle aged
osteolysis
procedures
young adult
LA - English
PY - 2018
SN - 1559-2863
SP - 250-260
ST - Does the Use of a "Walking Bleaching" Technique Increase Bone Resorption
Markers?
T2 - Oper Dent
TI - Does the Use of a "Walking Bleaching" Technique Increase Bone Resorption
Markers?
VL - 43
ID - 13632
ER -
TY - JOUR
AB - In Asian nations, the spice curcuma longa (often known as turmeric) is
utilised in traditional medicine. Curcumin, which is the most active component, has
a lot of therapeutic potential. Turmeric, a rhizome of the Curcuma longa plant, is
a more palatable and practical alternative for the average person. It has been
proven to have hepatoprotective, anti-inflammatory, antioxidant, antiseptic,
antibacterial, and antimutagenic effects. These characteristics make it highly
valuable in dentistry, particularly for the treatment of periodontal disease and
oral cancer. It aids in the local delivery of medication when used in the gel form.
Additionally, it can be utilised in various mouthwash formulations, subgingival
irrigants, and pit and fissure sealants. This article looks at its medical uses in
dentistry.
AN - rayyan-563562570
AU - Bhandary, S.
AU - Shetty, M. S.
AU - Sharma, D.
AU - Tanna, D. A.
AU - Jain, M.
DO - 10.3329/bjms.v22i20.66312
PY - 2023
SN - ["2223-4721", "2076-0299"]
SP - S67-+
ST - The Medicinal Chemistry of Curcuma Longa : A Narrative Review
T2 - BANGLADESH JOURNAL OF MEDICAL SCIENCE
TI - The Medicinal Chemistry of Curcuma Longa : A Narrative Review
VL - 22
ID - 15944
ER -
TY - JOUR
AB - In Asian nations, the spice curcuma longa (often known as turmeric) is
utilised in traditional medicine. Curcumin, which is the most active component, has
a lot of therapeutic potential. Turmeric, a rhizome of the Curcuma longa plant, is
a more palatable and practical alternative for the average person. It has been
proven to have hepatoprotective, anti-inflammatory, antioxidant, antiseptic,
antibacterial, and antimutagenic effects. These characteristics make it highly
valuable in dentistry, particularly for the treatment of periodontal disease and
oral cancer. It aids in the local delivery of medication when used in the gel form.
Additionally, it can be utilised in various mouthwash formulations, subgingival
irrigants, and pit and fissure sealants. This article looks at its medical uses in
dentistry.
AN - rayyan-563559714
AU - Bhandary, S.
AU - Shetty, M. S.
AU - Sharma, D.
AU - Tanna, D. A.
AU - Jain, M.
DO - 10.3329/bjms.v22i20.66312
KW - arachidonic acid
curcumin
didemethoxycurcumin
fissure sealant
mouthwash
phenylbutazone
prostaglandin
adjuvant arthritis
agar diffusion
antimutagenic activity
antiplatelet activity
aphthous stomatitis
bacterial strain
chemotherapy
clove
colon cancer
Curcuma longa
diarrhea
gingivitis
guava
human
inflammation
leukoplakia
lichen planus
liver protection
medicinal chemistry
mouth cancer
nonhuman
oral submucous fibrosis
periodontal disease
periodontitis
periodontium
phase 2 clinical trial (topic)
review
rhizome
skin disease
stomach irritation
stomach ulcer
swelling
thrombosis
tooth plaque
wound healing
LA - English
PY - 2023
SN - ["2076-0299", "2223-4721"]
SP - 67-71
ST - The Medicinal Chemistry of Curcuma Longa: A Narrative Review
T2 - Bangladesh J. Med. Sci.
TI - The Medicinal Chemistry of Curcuma Longa: A Narrative Review
VL - 22
ID - 13088
ER -
TY - JOUR
AB - Aims and objectives: The aim of the present study was to evaluate the
clinical and microbiological effcacy of locally delivered 1% curcumin gel as an
adjunct to scaling and root planing in the treatment of chronic periodontitis.
Materials and Methods: The study group consisted of 25 patients, belonging to both
sex, aged between 21-45 years. All patients diagnosed as chronic periodontitis with
periodontal pockets of depth >5mm bilaterally were randomly selected. A split mouth
design was followed and the patients received a complete prophylaxis including
scaling and root planing. Examination of plaque index, bleeding index, probing
pocket depth and clinical attachment level were measured for each patient. The test
group received 1% curcumin gel along with scaling and root planing whereas the
control group received scaling and root planing alone followed by microbiological
samples taken at baseline, 1, 3 and 6 months interval. Results: The 1% curcumin gel
appeared to provide signifcant improvements in clinical parameters. Microbiological
counts of Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum
and capnocytophaga showed signifcant reduction in periopathogens at the test sites
after six months when compared with that of control sites. Conclusion: Locally
delivered 1% curcumin gel was more effective in inhibiting the growth of oral
bacteria when used as an adjunct to SRP in the treatment of chronic periodontitis.
AN - rayyan-563560413
AU - Bhatia, M.
AU - Urolagin, S. S.
AU - Pentyala, K. B.
AU - Urolagin, S. B.
AU - Menaka, K. B.
AU - Bhoi, S.
DO - 10.7860/JCDR/2014/8231.5343
IS - 12
KW - curcumin
curcumin gel
distilled water
poloxamer
unclassified drug
adjuvant therapy
adult
article
bleeding index
Capnocytophaga
clinical article
comparative study
controlled study
drug efficacy
female
human
male
medical parameters
nonhuman
periodontal pocket
tooth plaque
LA - English
PY - 2014
SN - ["0973-709X", "2249-782X"]
SP - ZC65-ZC69
ST - Novel therapeutic approach for the treatment of periodontitis by curcumin
T2 - J. Clin. Diagn. Res.
TI - Novel therapeutic approach for the treatment of periodontitis by curcumin
VL - 8
ID - 13787
ER -
TY - JOUR
AB - Background: To compare the action of intracanal medicaments: Calcium
hydroxide and 2% Chlorhexidine, 10% Metronidazole gel, Septilin and 2% Chitosan as
intracanal medicaments after instrumentation with One curve® (Micromega) Rotary
Single-file System at 6 hrs, 12 hrs, 24 hrs, 48 hrs, 72 hrs and one week. Method:
Total of 50 mandibular molars were included (n=50) with occlusal caries and mild to
moderate pre-operative pain with minimal periapical radiolucency. After completing
access cavity preparation under local anaesthesia and isolation with rubber dam,
instrumentation with One curve single file was completed and patients divided into
groups of medicaments with a group of no medicaments or only normal saline. The
data was statistically analysed using Friedman’s two way analysis, Kruskal Wallis
ANOVA and Post hoc pairwise comparison. Results: In all the study groups, there was
significant decrease in post-operative pain at 6 hrs. Calcium hydroxide with 2%
Chlorhexidine showed significant decrease in post-operative pain and its efficacy
was evident from 24 hrs upto 7 days. Metronidazole 10% intracanal medicament at 6
hrs and 12 hrs showed maximum pain reduction post-operatively, which had sustained
effect upto 7 days. Conclusion: In accordance to the results, it could be concluded
that 10% Metronidazole and Calcium hydroxide plus 2% Chlorhexidine proved to be
beneficial for reducing post-operative pain followed by Septilin; Septilin and 2%
Chitosan showed shorter duration of efficacy as compared to other medicaments.
AN - rayyan-563560057
AU - Bhawalkar, A.
AU - Mulay, S.
AU - Desai, H.
AU - Shetty, R.
IS - 12
KW - CTRI/2021/03/032269
Electronic Pulp Tester
mechanical stirrer
One curve
orthodontic device
ParkellTM
rotary single file system
ultrasonic scaler
X ray film
calcium hydroxide
chitosan
chlorhexidine
metronidazole
septilin
sodium chloride
unclassified drug
adolescent
adult
article
child
clinical article
controlled study
dental caries
drug release
human
intracanal medicament
local anesthesia
mandible
molar tooth
pain assessment
periodontitis
pH
plaque index
postoperative pain
pulp vitality test
surface property
tooth root canal
LA - English
PY - 2021
SN - ["0976-1691", "0971-9032"]
ST - Comparative evaluation of post-operative endodontic pain using various
intracanal medicaments after instrumentation with rotary single-file system
T2 - Curr. Paediatr. Res.
TI - Comparative evaluation of post-operative endodontic pain using various
intracanal medicaments after instrumentation with rotary single-file system
VL - 25
ID - 13431
ER -
TY - JOUR
AB - Evasion of killing by the complement system, a crucial part of innate
immunity, is a key evolutionary strategy of many human pathogens. A major
etiological agent of chronic periodontitis, the Gram-negative bacterium
Porphyromonas gingivalis, produces a vast arsenal of virulence factors that
compromise human defense mechanisms. One of these is peptidylarginine deiminase
(PPAD), an enzyme unique to P. gingivalis among bacteria, which converts Arg
residues in polypeptide chains into citrulline. Here, we report that PPAD
citrullination of a critical C-terminal arginine of the anaphylatoxin C5a disabled
the protein function. Treatment of C5a with PPAD in vitro resulted in decreased
chemotaxis of human neutrophils and diminished calcium signaling in monocytic cell
line U937 transfected with the C5a receptor (C5aR) and loaded with a fluorescent
intracellular calcium probe: Fura-2 AM. Moreover, a low degree of citrullination of
internal arginine residues by PPAD was also detected using mass spectrometry.
Further, after treatment of C5 with outer membrane vesicles naturally shed by P.
gingivalis, we observed generation of C5a totally citrullinated at the C-terminal
Arg-74 residue (Arg74Cit). In stark contrast, only native C5a was detected after
treatment with PPAD-null outer membrane vesicles. Our study suggests reduced
antibacterial and proinflammatory capacity of citrullinated C5a, achieved via lower
level of chemotactic potential of the modified molecule, and weaker cell
activation. In the context of previous studies, which showed crosstalk between C5aR
and Toll-like receptors, as well as enhanced arthritis development in mice infected
with PPAD-expressing P. gingivalis, our findings support a crucial role of PPAD in
the virulence of P. gingivalis.
AN - rayyan-563561372
AU - Bielecka, E.
AU - Scavenius, C.
AU - Kantyka, T.
AU - Jusko, M.
AU - Mizgalska, D.
AU - Szmigielski, B.
AU - Potempa, B.
AU - Enghild, J. J.
AU - Prossnitz, E. R.
AU - Blom, A. M.
AU - Potempa, J.
DO - 10.1074/jbc.C114.617142
IS - 47
J2 - J Biol Chem
KW - Arginine/metabolism
Bacterial Proteins/genetics/*metabolism
Calcium/metabolism
Cell Membrane/enzymology
Cell Movement
Cells, Cultured
Chemotaxis
Citrulline/metabolism
Complement C5a/*metabolism
Electrophoresis, Polyacrylamide Gel
Humans
Hydrolases/genetics/*metabolism
Mutation
Neutrophils/cytology/metabolism
Porphyromonas gingivalis/*enzymology/genetics
Protein-Arginine Deiminases
Receptor, Anaphylatoxin C5a/genetics/metabolism
Transport Vesicles/enzymology
U937 Cells
LA - eng
N1 - From the Department of Laboratory Medicine, Medical Protein Chemistry, Lund
University, SE-205 02 Malmö, Sweden, the Department of Microbiology, Faculty of
Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Krakow,
Poland.; the Department of Molecular Biology and Genetics and Interdisciplinary
Nanoscience Center, Aarhus University, DK-8000 Aarhus, Denmark.; the Department of
Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian
University, 30-387 Krakow, Poland.; From the Department of Laboratory Medicine,
Medical Protein Chemistry, Lund University, SE-205 02 Malmö, Sweden.; the
Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology,
Jagiellonian University, 30-387 Krakow, Poland.; the Department of Microbiology,
Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-
387 Krakow, Poland.; the Department of Oral Immunology and Infectious Diseases,
University of Louisville School of Dentistry, Louisville, Kentucky 40202, and.; the
Department of Molecular Biology and Genetics and Interdisciplinary Nanoscience
Center, Aarhus University, DK-8000 Aarhus, Denmark.; the Department of Cell Biology
and Physiology, University of New Mexico, Albuquerque, New Mexico 87131.; From the
Department of Laboratory Medicine, Medical Protein Chemistry, Lund University, SE-
205 02 Malmö, Sweden, anna.blom@med.lu.se.; the Department of Microbiology, Faculty
of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387
Krakow, Poland.
PY - 2014
SN - 1083-351X (Electronic)
SP - 32481-7
ST - Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes
anaphylatoxin C5a activity
T2 - The Journal of biological chemistry
TI - Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes
anaphylatoxin C5a activity
VL - 289
Y2 - 11 y3 - 21
ID - 14746
ER -
TY - JOUR
AB - Background and Objective: Orthodontic tooth movement requires remodeling of
the periodontal tissues. The matrix metalloproteinases (MMPs) degrade the
extracellular matrix components of the periodontal ligament, while the tissue
inhibitors of metalloproteinases (TIMPs) control their activity. Synthetic MMP
inhibitors have been developed to inhibit MMP activity. In this study, periodontal
ligament cells in contracting collagen gels served as a model for enhanced
periodontal remodeling. The effect of MMP inhibitors on gel contraction and on MMP
and TIMP expression was analyzed. Material and Methods: Human periodontal ligament
cells were cultured in three-dimensional collagen gels and incubated with the MMP
inhibitors BB94, CMT-3, doxycycline and Ilomastat. Gel contraction was determined
using consecutive photographs. The relative amounts of MMPs and TIMPs were analyzed
using substrate zymography and mRNA expression using quantitative polyermase chain
reaction. Results: All MMP inhibitors reduced MMP activity to about 20% of the
control activity. They all reduced contraction, but CMT-3 and doxycycline had the
strongest effect. These inhibitors also reduced MMP-2, MMP-3 and -smooth muscle
actin mRNA expression. The expression of MMP-1 mRNA seemed to be increased by CMT-
3. No effects were found on the amounts of MMPs and TIMPs. Conclusion: Synthetic
MMP inhibitors strongly reduced gel contraction by periodontal ligament cells. This
was primarily caused by an inhibitory effect on MMP activity, which reduces matrix
remodeling. In addition, -smooth muscle actin expression was reduced by CMT-3 and
doxycycline, which limits the contractile activity of the fibroblasts. © 2008
Blackwell Munksgaard.
AN - rayyan-563560679
AU - Bildt, M. M.
AU - Bloemen, M.
AU - Kuijpers-Jagtman, A. M.
AU - Von Den Hoff, J. W.
DO - 10.1111/j.1600-0765.2008.01127.x
IS - 2
KW - actin
batimastat
collagen
doxycycline
drug derivative
ilomastat
indole derivative
phenylalanine
proteinase inhibitor
tetracycline CMT 3
tetracycline CMT-3
tetracycline derivative
thiophene derivative
tissue inhibitor of metalloproteinase
article
biosynthesis
cell culture
cell culture technique
cytology
dental procedure
drug antagonism
drug effect
enzymology
fibroblast
gel
human
periodontal disease
physiology
LA - English
PY - 2009
SN - 0022-3484
SP - 266-274
ST - Matrix metalloproteinase inhibitors reduce collagen gel contraction and -
smooth muscle actin expression by periodontal ligament cells
TI - Matrix metalloproteinase inhibitors reduce collagen gel contraction and -
smooth muscle actin expression by periodontal ligament cells
VL - 44
ID - 14053
ER -
TY - JOUR
AB - Background and Objective: The purpose of this study was to investigate the
effects of chemically modified tetracyclines (CMTs) on the production of
gelatinases [matrix metalloproteinase (MMP)-2 and -9] by human periodontal ligament
(PDL) cells, and on the activity of recombinant gelatinases. Material and Methods:
Human PDL cells were cultured with CMT-1, -3, -5, -7 or -8 in concentrations of 0,
1, 5, 10, 20, 50, 100, 200 and 500 μm. Gelatin zymography was used to determine
MMP-2 and -9 production of the cells. The amount of DNA present in the cultures was
analyzed using a fluorescent assay. The cytotoxicity of the CMTs was also
determined. Recombinant human MMP-2 and -9 were incubated with the CMTs (0-500 μm)
and their activity was analyzed using an internally quenched fluorogenic substrate.
Results: MMP-2 production was stimulated up to sevenfold by CMT-1, -3, -7 and -8 at
low concentrations (10-200 μm). No significant amounts of MMP-9 were produced. In
contrast, MMP-2 and -9 activity was reduced by ≈ 10-40-fold at higher
concentrations (200-500 μm). CMT-5 had no effect on the production or on the
activity of MMP-2 and -9. Only CMT-3 and -8 had cytotoxic effects on the PDL cells
at the highest concentrations. Conclusion: Surprisingly, CMTs are able to stimulate
MMP-2 production at relatively low concentrations. However, at higher
concentrations they exert a much stronger inhibitory effect on gelatinase activity.
A possible stimulatory effect of CMTs on MMP production should be considered in
their clinical use. © 2006 The Authors.
AN - rayyan-563560758
AU - Bildt, M. M.
AU - Snoek-Van Beurden, A. M. P.
AU - DeGroot, J.
AU - Van El, B.
AU - Kuijpers-Jagtman, A. M.
AU - Von Den Hoff, J. W.
DO - 10.1111/j.1600-0765.2006.00893.x
IS - 5
KW - DNA
enzyme inhibitor
gelatin
gelatinase A
gelatinase B
recombinant protein
article
biosynthesis
cell culture
chemistry
drug antagonism
drug effect
human
metabolism
nonparametric test
Western blotting
LA - English
PY - 2006
SN - 0022-3484
SP - 463-470
ST - Chemically modified tetracyclines stimulate matrix metalloproteinase-2
production by periodontal ligament cells
TI - Chemically modified tetracyclines stimulate matrix metalloproteinase-2
production by periodontal ligament cells
VL - 41
ID - 14132
ER -
TY - JOUR
AN - rayyan-563561786
AU - Bintiazeran, N. S.
AU - Diyanabintizazali, N.
AU - Sedatimur, S.
AU - Özdoǧan, A. L.
AU - Ekizoǧlu, M.
AU - Sheshala, R.
AU - Dua, K.
AU - Sahu, P. S.
AU - Şenel, S.
IS - 1
PY - 2017
SP - 157-169
ST - Moxifloxacin loaded chitosan gel formulations for the treatment of
periodontal diseases
T2 - Journal of Polymer Materials
TI - Moxifloxacin loaded chitosan gel formulations for the treatment of
85024896593&partnerID=40&md5=17d0a59f79e54831f1e3dde6cad94dc5
VL - 34
ID - 15160
ER -
TY - JOUR
AB - Aim: Adenosine receptors modulate inflammation in periodontal tissues. No
data are available regarding the effects of adenosine A2A receptor stimulation in
experimental periodontitis (EPD). The aim of this study was to investigate the
effects of polynucleotides (also known as polydeoxyribonucleotide, PDRN), a ligand
of A2A receptor, in EPD in rats. Materials and Methods EPD was induced ligating the
cervix of the lower left first molar. Sham-EPD had no ligature. After 7 days, EPD
animals were randomized to a daily treatment with vehicle gel or 0.75% PDRN gel or
PDRN gel with a specific A2A antagonist (DMPX). Treatments lasted 7 days. Animals
were then euthanized and the periodontium and surrounding gingival tissue were
excised for histological evaluation and bio-molecular analysis of inflammatory (p-
JNK, p-ERK, TNF-α, IL-6, HMGB-1) and apoptotic proteins (BAX and Bcl-2). Results:
Vehicle-treated EPD rats showed severe inflammatory infiltrate in both gingival and
periodontal ligament, as well as an enhanced expression of p-JNK, p-ERK, TNF-α, IL-
6, HMGB-1 and BAX and a reduction in Bcl-2. PDRN gel restored the histological
features, blunted inflammatory and apoptotic proteins expression and preserved Bcl-
2 expression. DMPX abrogated PDRN positive effects. Conclusion: Our data suggest
that adenosine receptor stimulation by PDRN might represent a new therapeutic
strategy for periodontitis. © 2012 John Wiley & Sons A/S.
AN - rayyan-563560510
AU - Bitto, A.
AU - Oteri, G.
AU - Pisano, M.
AU - Polito, F.
AU - Irrera, N.
AU - Minutoli, L.
AU - Squadrito, F.
AU - Altavilla, D.
DO - 10.1111/jcpe.12010
IS - 1
KW - 3,7 dimethyl 1 propargylxanthine
adenosine A2 receptor antagonist
adenosine receptor
autacoid
drug derivative
high mobility group B1 protein
interleukin 6
polydeoxyribonucleotide
protein Bax
protein bcl 2
stress activated protein kinase
theobromine
alveolar bone loss
animal
article
drug effect
male
metabolism
periodontitis
randomization
rat
Sprague Dawley rat
LA - English
PY - 2013
SN - ["0303-6979", "1600-051X"]
SP - 26-32
ST - Adenosine receptor stimulation by polynucleotides (PDRN) reduces inflammation
in experimental periodontitis
TI - Adenosine receptor stimulation by polynucleotides (PDRN) reduces inflammation
in experimental periodontitis
VL - 40
ID - 13884
ER -
TY - JOUR
AB - Objectives: Optimization of standard mechanical/instrumental therapy by
developing and improvement of extemporal medicines in rinse and gel forms for
topical treatment of generalized periodontitis (GP).Comparative analysis of Papilla
Bleeding Index (PBI) and Periodonal Disease Index (PDI) dynamics for two patient
groups with GP: main (25 person –modified complexes) and comparison (23 person –
based treatment) before treatment and one month after treatment of GP. Each group
was divided into two subgroups depending on diagnoses – GPI (probing depth 0-3mm)
and GPII (probing depth 4-6mm). Methods: Medicines for local treatment of
periodontal diseases: in rinse form containing miramistin and propilenglicol were
modified by adding liquid extract of Rhus typhina, ascorbic acid, calcium lactate,
glycyrram and menthol; gel form containing miramistin, natrium-
carboxymethylcellulose, methylcellulose and propilenglicol were modified by adding
liquid extract of Rhus typhina, ascorbic acid, ruthin, menthol. Results: Before
treatment, level of periodontal indexes of patients in corresponding subgroups of
main and comparison group didn't differ significantly (p>0.05). One month after
treatment: Values of РВІ index significantly decreased in all subgroups. Comparison
of РВІ indices showed great РВІ decrease in main group. In subgroup with GPI in
main group, РВІ decreased by 43,55% (from 2,48±0,08 to 1,40±0,05), in subgroup with
GPI of comparison group – by 40,15% (from 2,64±0,09 to 1,58±0,06). In subgroups
with GPII, reduction rates were 52.41% (from 3,11±0,08 to 1,48±0,05) in main group
and 54.28% (3,39±0,09 to 1,55±0,05) in comparison group. In patient subgroups with
GPI index PDI decreased by 54.80% (2,81±0,12 to 1,27±0,05) in main group and by
48.44% (2,89±0,13 to 1,49±0,06) in comparison group; in subgroups with GPII - by
40.98%(4,27±0,12 to 2,52±0,07) and 37.30% (4,29±0,15 to 2,69±0,08), respectively.
Conclusions: After treatment, periodontal indexes were significantly lower in all
subgroups of main group than in comparison group (p<0.05). This indicates positive
effect/effectiveness of modified treatment use for patients with GP.
AN - rayyan-563560243
AU - Blavatska, O.
AU - Minko, L.
AU - Slaba, O.
AU - Sichkoriz, K.
DO - 10.1016/j.jval.2018.07.816
KW - ascorbic acid
calcium lactate
glycyrrhizic acid
menthol
methylcellulose
unclassified drug
adult
bleeding
clinical article
conference abstract
controlled study
diagnosis
female
human
local therapy
male
nonhuman
periodontal index
periodontitis
Rhus
topical treatment
LA - English
PY - 2018
SN - ["1524-4733", "1098-3015"]
SP - S107
ST - Optimization of Pharmacotherapy for Generalized Periodontitis Treatment
T2 - Value Health
TI - Optimization of Pharmacotherapy for Generalized Periodontitis Treatment
VL - 21
ID - 13617
ER -
TY - JOUR
AB - Since the discovery of bioactive glass (BG) 50+ years ago by Prof. Larry
Hench, these bone bonding materials have received increasing attention, mainly for
orthopedic and dental applications. A great variety of compositions (silicate,
phosphate and borate systems) is now available, which can be produced by the
traditional melting technology or by sol-gel methods, thus expanding the scope of
BG applications. More recently, BGs and glass-ceramics have started to be
investigated in the tissue engineering (TE) field, for hard (bone) TE, periodontal
regeneration, soft tissue repair and wound healing. Such applications rely on the
biochemical reactions occurring at the interface between the material surface and
the biological environment, which involve the (controlled) release of biologically
active ions as dissolution products to stimulate specific cellular responses
involved in new tissue growth [1]. In the case of bioactive glass-ceramics, the
partition of ions between the glassy and the crystalline phases can lead to
interesting biomaterials with tailored ion release capability. In addition,
immunomodulatory effects of BGs in the framework of bone regeneration and wound
healing are being increasingly investigated [2]. The first part of the lecture will
give an overview on the field of bioactive glasses with emphasis on the systems
that exhibit the capability for the release of biologically active ions for
achieving desired biological outcomes, e.g. osteogenic, antibacterial,
mineralization effects. In addition, selected metal ions released from BGs can
induce an angiogenic effect, e.g. in specific concentrations the ionic products of
BGs enhance the secretion of vascular endothelial growth factor from stem cells, a
very important property for tissue regeneration. Such angiogenic effects of BGs
will be discussed in the second part of the lecture, showing results on different
scaffold types and BG compositions. Moreover, cell culture studies considering the
variation of ion concentration (BG dissolution products) in cell culture medium and
the resultant time dependent effects on stem cells will be presented. In this
context, applications of ion releasing BGs obtained by the sol-gel technique have
been emerging in the field of restorative dentistry, e.g. as fillers focusing on
the treatment of hypersensitive dentine, for pulp-dentine tissue engineering, and
for target drug delivery [3]. A summary of research on sol-gel derived BGs leading
to improved biological properties, antibacterial effects, hardness, acid buffering
and remineralization, will be presented. Finally, the challenges and opportunities
for further research in the field will be discussed.
AN - rayyan-563559850
AU - Boccaccini, A. R.
IS - 2
boric acid
endogenous compound
glass
metal ion
phosphate
silicate
vasculotropin
attention
bone regeneration
bone tissue
ceramics
conference abstract
controlled study
culture medium
dentin
dentin hypersensitivity
dissolution
hardness
human cell
human tissue
melting point
mineralization
periodontium
soft tissue
sol-gel
spectacles
stem cell
surgery
tissue engineering
tissue growth
tissue regeneration
tissue repair
wound healing
LA - ["English", "Croatian"]
PY - 2022
SN - 1846-0410
SP - 185-186
ST - 50 YEARS OF BIOACTIVE GLASSES: TRADITIONAL, CURRENT AND FUTURE APPLICATIONS
T2 - 50 GODINA BIOAKTIVNIH STAKALA: TRADICIONALNE, SADAŠNJE I BUDUĆE APLIKACIJE
TI - 50 YEARS OF BIOACTIVE GLASSES: TRADITIONAL, CURRENT AND FUTURE APPLICATIONS
VL - 56
ID - 13224
ER -
TY - JOUR
AB - Background: Adjunctive locally delivered antibiotics during maintenance may
favor the control of periodontal infections. This study evaluated the long-term
clinical and microbiologic effects of yearly locally delivered controlled-release
doxycycline as an adjunct to mechanical debridement. Methods: A total of 128
periodontal maintenance patients having at least four teeth with probing depth (PD)
≥5 mm were randomly assigned to local application of doxycycline gel at baseline
and 1 and 2 years as an adjunct to mechanical debridement (test) or mechanical
debridement only (control). Supportive periodontal therapy (mechanical debridement,
polishing, and oral hygiene reinforcement) was provided every 6 months. Plaque,
bleeding on probing (BOP), PD, and relative attachment level (RAL) were scored at
baseline; 3 months; and 1, 2, and 3 years. Subgingival plaque samples were taken at
each examination and analyzed for their content of 40 bacterial species. Data
analyses were performed on an intention-to-treat basis with the subject as the
statistical unit. Results: Significant reductions in BOP, PD, RAL, and the mean
counts of a number of target species between baseline and 3 years were documented
for both treatment groups, whereas plaque scores remained unchanged. A
statistically significant difference in favor of the adjunctive doxycycline therapy
was found between the two groups only at the 3-month examination for BOP, PD, and
RAL and for a minority of bacterial species at 2 years. Conclusion: Although short-
term effects on clinical parameters were found with the adjunctive use of locally
delivered doxycycline, repeated applications annually had no clinical or
microbiologic effects beyond those observed with mechanical debridement alone in
maintenance patients.
AN - rayyan-563560711
AU - Bogren, A.
AU - Teles, R. P.
AU - Torresyap, G.
AU - Haffajee, A. D.
AU - Socransky, S. S.
AU - Wennström, J. L.
DO - 10.1902/jop.2008.070515
IS - 5
KW - doxycycline
adult
aged
article
bacterium
classification
clinical trial
controlled study
drug effect
female
gel
human
longitudinal study
male
microbiology
middle aged
multicenter study
periodontics
periodontitis
retreatment
treatment outcome
LA - English
PY - 2008
SN - 0022-3492
SP - 827-835
ST - Locally delivered doxycycline during supportive periodontal therapy: A 3-year
study
TI - Locally delivered doxycycline during supportive periodontal therapy: A 3-year
study
VL - 79
ID - 14085
ER -
TY - JOUR
AB - INTRODUCTION: Our aim was to evaluate the effect of a gingival gel containing
chlorhexidine and Rheum Palmatum extract on gingival fragments stimulated by SP
(substance P) and lipopolysaccharides (LPS). MATERIALS AND METHODS: Gingival
fragments were maintained in survival for 3 days at 37 degrees C. To induce
inflammation, SP and LPS were applied to the culture medium in contact with the
corium. The gingival gel was applied on epithelium. Histological analysis was then
performed on hematoxylin and eosin stained slides. Edema was evaluated with semi-
quantitative scores. Vasodilation was studied by counting the percent of dilated
vessels according to scores and the surface of these dilated vessels by
morphometrical image analysis. An inflammatory cytokine, IL8, was measured in
culture supernatants. Immunohistochemical expression of metalloproteinase type 9
(MMP9) implicated in inflammatory processes, was also studied (% of positive
cells). RESULTS: Edema, vasodilation and IL8 were significantly increased after
application of SP and LPS. Application of gingival gel showed a significant
decrease of these parameters. A significant decrease of MMP9 on fibroblasts and
mononuclear cells was observed after use of gingival gel.
AN - rayyan-563560878
AU - Boisnic, S.
AU - Ben Slama, L.
AU - Branchet-Gumila, M. C.
AU - d'Arros, G.
IS - 4
KW - chlorhexidine
coloring agent
diagnostic agent
gelatinase B
interleukin 8
lipopolysaccharide
plant extract
substance P
article
capillary
cell culture
drug effect
gel
gingiva
gingivitis
human
image processing
lesions and defects
pathology
phytotherapy
rhubarb
vascularization
LA - French
PY - 2003
SN - 0035-1768
SP - 201-205
ST - Contribution of Parodium gel in an experimental model of human gingival
inflammation
T2 - Intérêt du gel parodium dans un modèle d'inflammation expérimentale de la
muqueuse gingivale humaine maintenue en survie.
TI - Contribution of Parodium gel in an experimental model of human gingival
inflammation
VL - 104
ID - 14252
ER -
TY - JOUR
AB - A treatment for periodontal infections often consists of consecutive
rootplanings (per quadrant, at a 1- to 2-week interval), without a proper
disinfection of the remaining intra-oral niches (untreated pockets, tongue, saliva,
mucosa and tonsils). Such an approach, could theoretically lead to a reinfection of
previously-treated pockets. The present study aims to examine the effect of a full-
mouth disinfection on the microbiota in the above-mentioned niches. Moreover, the
clinical benefit of such an approach was investigated, 16 patients with severe
periodontitis were randomly allocated to a test and a control group, The patients
from the control group were sealed and rootplaned, per quadrant, at 2-week
intervals and obtained oral hygiene instructions. The patients from the test group
received a full-mouth disinfection consisting of scaling and rootplaning of all
pockets in 2 visits within 24 h. in combination with tongue brushing with 1%
chlorhexidine gel for 1 min, mouth rinsing with a 0.2% chlorhexidine solution for 2
min and subgingival irrigation of all pockets (3x in 10 min) with 1% chlorhexidine
gel. Besides oral hygiene, the test group rinsed 2x daily with 0.2% chlorhexidine
and sprayed the tonsils with a 0.2% chlorhexidine for 2 months, Plaque samples
(pockets, tongue, mucosa and saliva) were taken at baseline and after 2 and 4
months, and changes in probing depth. attachment level and bleeding on probing were
reported, The full-mouth disinfection resulted in a statistically significant:
additional reduction elimination of periodontopathogens, especially in the
subgingival pockets, but also in the other niches, These microbiological
improvements were reflected in a statistically-significant higher probing depth
reduction and attachment gain in the test patients. These findings suggest that a
disinfection of all intra-oral niches within a, short time span leads to
significant clinical and microbiological improvements for up to 4 months.
AN - rayyan-563562411
AU - Bollen, C. M. L.
AU - Mongardini, C.
AU - Papaioannou, W.
AU - Van Steenberghe, D.
AU - Quirynen, M.
DO - 10.1111/j.1600-051X.1998.tb02364.x
IS - 1
PY - 1998
SN - ["0303-6979", "1600-051X"]
SP - 56-66
ST - The effect of a one-stage full-mouth disinfection on different intra-oral
niches - Clinical and microbiological observations
TI - The effect of a one-stage full-mouth disinfection on different intra-oral
niches - Clinical and microbiological observations
VL - 25
Y2 - 1
ID - 15785
ER -
TY - JOUR
AB - A standard periodontal treatment consists of 4 to 6 scalings and root-
planings at a 1- to 2-week interval, which allows reinfection of a previously
disinfected area before completion of the treatment. The present pilot study aims
to examine the microbiological long-term effects of a full-mouth disinfection. 10
patients with advanced chronic periodontitis were randomly allocated to a test and
control group. The patients from the control group received scaling and root-
planing and oral hygiene instructions at a 2-week interval. The full-mouth
disinfection (test group) consisted of a full-mouth scaling and rootplaning in 2
visits within 24 h in combination with: tongue brushing with 1% chlorhexidine gel
for 1 min, mouth rinsing with 0.2% chlorhexidine solution for 2 min and subgingival
irrigation of all pockets (3x in 10 min) with 1% chlorhexidine gel. The patients of
the test group were instructed to rinse 2x daily with 0.2% chlorhexidine. Plaque
samples were taken at baseline and after 1, 2, 4 and 8 months. Differential phase-
contrast microscopy showed a significantly larger reduction of spirochetes and
motile organisms in the test group up to month 2 for the single-rooted and up to
month 8 for the multi-rooted teeth. Furthermore, the culture data supported the
effectiveness of the new treatment strategy. In both groups, the number of
anaerobic CFU decreased 1 log around single- and 0.5 log around multi-rooted teeth.
The number of anaerobic CFU remained low in the test group, in contrast to the
control group. At 1 month, the test group harboured a significantly (p<0.01) lower
proportion of pathogenic organisms, but this difference disappeared with time.
Moreover, the test sites showed a significantly higher (p<0.02) increase in the
proportion of beneficial micro-organisms up to 4 months. These findings suggest
that a full-mouth disinfection leads to a significant microbiological improvement
up to 2 months, which could be consolidated, although not significant, for the next
6 months.
AN - rayyan-563562309
AU - Vandekerckhove, B. N. A.
AU - VanEldere, J.
AU - Quirynen, M.
DO - 10.1111/j.1600-051X.1996.tb00519.x
IS - 10
PY - 1996
SN - 0303-6979
SP - 960-970
ST - Full- versus partial-mouth disinfection in the treatment of periodontal
infections - A pilot study: Long-term microbiological observations
TI - Full- versus partial-mouth disinfection in the treatment of periodontal
infections - A pilot study: Long-term microbiological observations
VL - 23
Y2 - 10
ID - 15683
ER -
TY - JOUR
AB - A treatment for periodontal infections often consists of consecutive
rootplanings (per quadrant, at a 1- to 2-week interval), without a proper
disinfection of the remaining intra-oral niches (untreated pockets, tongue, saliva,
mucosa and tonsils). Such an approach, could theoretically lead to a reinfection of
previously-treated pockets. The present study aims to examine the effect of a full-
mouth disinfection on the microbiota in the above-mentioned niches. Moreover, the
clinical benefit of such an approach was investigated. 16 patients with severe
periodontitis were randomly allocated to a test and a control group. The patients
from the control group were scaled and rootplaned, per quadrant, at 2-week
intervals and obtained oral hygiene instructions. The patients from the test group
received a full-mouth disinfection consisting of: scaling and rootplaning of all
pockets in 2 visits within 24 h, in combination with tongue brushing with 1%
chlorhexidine gel for 1 min, mouth rinsing with a 0.2% chlorhexidine solution for 2
min and subgingival irrigation of all pockets (3x in 10 min) with 1% chlorhexidine
gel. Besides oral hygiene, the test group rinsed 2x daily with 0.2% chlorhexidine
and sprayed the tonsils with a 0.2% chlorhexidine for 2 months. Plaque samples
(pockets, tongue, mucosa and saliva) were taken at baseline and after 2 and 4
months, and changes in probing depth, attachment level and bleeding on probing were
reported. The full-mouth disinfection resulted in a statistically significant
additional reduction/elimination of periodontopathogens, especially in the
subgingival pockets, but also in the other niches. These microbiological
improvements were reflected in a statistically-significant higher probing depth
reduction and attachment gain in the test patients. These findings suggest that a
disinfection of all intra-oral niches within a short time span leads to significant
clinical and microbiological improvements for up to 4 months.
AN - rayyan-563561032
AU - Bollen, C. M.
AU - Mongardini, C.
AU - Van Steenberghe, D.
AU - Quirynen, M.
IS - 1
KW - chlorhexidine
adult
aerosol
aged
article
clinical trial
controlled study
drug effect
female
follow up
gingiva bleeding
human
lavage
male
microbiology
middle aged
mouth
mouth hygiene
mouth mucosa
patient education
periodontal disease
periodontitis
recurrent disease
saliva
tongue
tonsil
tooth brushing
tooth plaque
LA - English
PY - 1998
SN - 0303-6979
SP - 56-66
ST - The effect of a one-stage full-mouth disinfection on different intra-oral
niches. Clinical and microbiological observations
TI - The effect of a one-stage full-mouth disinfection on different intra-oral
niches. Clinical and microbiological observations
VL - 25
ID - 14406
ER -
TY - JOUR
AB - A standard periodontal treatment consists of 4 to 6 scalings and rootplanings
at a 1- to 2-week interval, which allows reinfection of a previously disinfected
area before completion of the treatment. The present pilot study aims to examine
the microbiological long-term effects of a full-mouth disinfection. 10 patients
with advanced chronic periodontitis were randomly allocated to a test and control
group. The patients from the control group received scaling and rootplaning and
oral hygiene instructions at a 2-week interval. The full-mouth disinfection (test
group) consisted of a full-mouth scaling and rootplaning in 2 visits within 24 h in
combination with: tongue brushing with 1% chlorhexidine gel for 1 min, mouth
rinsing with 0.2% chlorhexidine solution for 2 min and subgingival irrigation of
all pockets (3x in 10 min) with 1% chlorhexidine gel. The patients of the test
group were instructed to rinse 2x daily with 0.2% chlorhexidine. Plaque samples
were taken at baseline and after 1, 2, 4 and 8 months. Differential phase-contrast
microscopy showed a significantly larger reduction of spirochetes and motile
organisms in the test group up to month 2 for the single-rooted and up to month 8
for the multi-rooted teeth. Furthermore, the culture data supported the
effectiveness of the new treatment strategy. In both groups, the number of
anaerobic CFU decreased 1 log around single- and 0.5 log around multi-rooted teeth.
The number of anaerobic CFU remained low in the test group, in contrast to the
control group. At 1 month, the test group harboured a significantly (p<0.01) lower
proportion of pathogenic organisms, but this difference disappeared with time.
Moreover, the test sites showed a significantly higher (p<0.02) increase in the
proportion of beneficial micro-organisms up to 4 months. These findings suggest
that a full-mouth disinfection leads to a significant microbiological improvement
up to 2 months, which could be consolidated, although not significant, for the next
6 months.
AN - rayyan-563561054
AU - Bollen, C. M.
AU - Vandekerckhove, B. N.
AU - Van Eldere, J.
AU - Quirynen, M.
IS - 10
KW - chlorhexidine
adult
anaerobic bacterium
article
bacterial count
bacterial infection
clinical trial
controlled study
drug effect
female
follow up
gel
human
lavage
longitudinal study
male
microbiology
middle aged
mouth hygiene
patient education
periodontitis
pilot study
spirochete
tongue
tooth brushing
tooth plaque
LA - English
PY - 1996
SN - 0303-6979
SP - 960-970
infections. A pilot study: long-term microbiological observations
infections. A pilot study: long-term microbiological observations
VL - 23
ID - 14428
ER -
TY - JOUR
AB - Medicinal uses of rhubarb roots have often been reported. The aim of this
current research is to evaluate the anti-bacterial and anti-proliferative effects
of the rhubarb stem. Aqueous extract from rhubarb stem was fractionated using DEAE
Sephadex (anion exchange) followed by Sephadex G25 (gel filtration). Fractions were
monitored by assaying for their antibacterial activity on the periodontal pathogen
Aggregatibacter actinomycetemcomitans. The fraction from gel filtration column
having antibacterial activity was used for further studies. Purity of the active
compound was confirmed by the presence of a single major peak in HPLC. The purified
active compound was found to have broad spectrum antibacterial activity. It
inhibited growth of the Gram negative bacteria, E. coli and A.
actinomycetemcomitans as well as the Gram positive bacteria, B subtilis. Its anti-
proliferative activity was tested on the breast cancer cell line, MCF-7. It was
observed that proliferation of the tumor cells was inhibited by 60 % while the cell
viability was not affected. The purified compound was partially characterized based
on its 1H and 13C NMR spectra. Preliminary analysis indicated that this compound is
carbohydrate but the exact identity of the sugar has not yet been determined. This
research helped to discover a compound in rhubarb stem that has antibacterial and
anti-tumor activity but very little cytotoxic effect.
AN - rayyan-563560490
AU - Bommareddy, P. K.
AU - Mrinal, B. K.
AU - Depass, A. L.
sephadex
carbohydrate
sugar
2 diethylaminoethanol
rhubarb
gel filtration
cell viability
tumor cell
carbon nuclear magnetic resonance
pathogenesis
cancer cell culture
breast cancer
anion exchange
Escherichia coli
identity
cytotoxicity
nuclear magnetic resonance
LA - English
PY - 2013
SN - 1530-6860
ST - Antibacterial and anti-proliferative activity of Isolated Fractions of
Aqueous extract from the rhubarb stem
T2 - FASEB J.
TI - Antibacterial and anti-proliferative activity of Isolated Fractions of
Aqueous extract from the rhubarb stem
VL - 27
ID - 13864
ER -
TY - JOUR
AB - Objective: This double-blind clinical study, conducted at the University of
Puerto Rico, San Juan, Puerto Rico, was designed to compare the efficacy of two
commercially available dentifrices for the control of supragingival plaque and
gingivitis. Methods: Qualifying adult male and female subjects from the San Juan,
Puerto Rico area were randomly assigned to one of two treatment groups: 1) a
commercially available dentifrice containing 0.3% triclosan, 2.0% PVM/MA copolymer,
and 0.243% sodium fluoride (Colgate® Total® and 2) a commercially available
dentifrice containing 0.454% stannous fluoride, sodium hexametaphosphate, and zinc
lactate (Crest®Pro-Health®All subjects received an oral soft and hard tissue
examination, and were dispensed their assigned dentifrice product, along with a
soft-bristled adult toothbrush for home use. Subjects were instructed to brush
their teeth for one minute, twice daily (morning and evening), using only the
dentifrice provided. Examinations for supragingival plaque and gingivitis, and oral
son and hard tissue assessments were repeated after six weeks, three months, and
six months of product use. Results: One-hundred and nine (109) subjects complied
with the protocol and completed the six-month examinations. At the sixmonth
examination, both treatment groups exhibited statistically significant reductions
from baseline with respect to supragingival plaque and gingivitis scores. Relative
to the Crest Pro-Health Toothpaste group, the Colgate Total Toothpaste group
exhibited statistically significant reductions in supragingival plaque index scores
of 18.5%, 20.7%, and 25.8% after six weeks, three months, and six months of product
use, respectively. For gingival index scores, statistically significant reductions
of 20.5%, 18.9%, and 17.1% were exhibited after six weeks, three months, and six
months of product use, respectively. Conclusion: The results of this double-blind
clinical study support the conclusion that a dentifrice containing 0.3% triclosan,
2.0% PVM/MA copolymer, and 0.243% sodium fluoride provides a significant reduction
in established supragingival plaque and gingivitis, as compared to a dentifrice
containing 0.454% stannous fluoride, sodium hexametaphosphate, and zinc lactate
when used over a period of six months.
AN - rayyan-563560620
AU - Boneta, A. E.
AU - Aguilar, M. M.
AU - Romeu, F. L.
AU - Stewart, B.
AU - DeVizio, W.
AU - Proskin, H. M.
IS - 4
KW - Crest Pro Health Dentifrice
Crest Pro-Health Dentifrice
sodium fluoride
hydrated silica gel based toothpaste
hydrated silica gel-based toothpaste
maleic acid derivative
methoxyethylene-maleic anhydride copolymer
phosphate
poly(maleic anhydride methyl vinyl ether)
polyethylene derivative
silicic acid
sodium polymetaphosphate
tin fluoride
toothpaste
triclosan
zinc derivative
adult
aged
article
chemistry
clinical trial
comparative study
controlled study
drug combination
female
gingivitis
human
male
middle aged
periodontics
tooth plaque
LA - English
PY - 2010
SN - 0895-8831
SP - 117-123
ST - Comparative investigation of the efficacy of triclosan/copolymer/sodium
fluoride and stannous fluoride/sodium hexametaphosphate/zinc-lactate- dentifrices-
for-the-control of established supragingival plaque and gingivitis in a six-month
clinical study
T2 - J. Clin. Dent.
TI - Comparative investigation of the efficacy of triclosan/copolymer/sodium
fluoride and stannous fluoride/sodium hexametaphosphate/zinc-lactate- dentifrices-
for-the-control of established supragingival plaque and gingivitis in a six-month
clinical study
VL - 21
ID - 13994
ER -
TY - JOUR
AB - Bioactive glasses are a group of surface reactive glass-ceramics and are able
to induce the formation of mineralized tissue in vivo, maxillofacial and
periodontal repair. In this work we are studied the 58S glass type produced in the
UFMG Biomaterials Laboratory using the sol-gel process comprising SiO2 (46.1 mol%),
P2O5 (4 mol%) and CaO (26.9 mol%) associated with green propolis originated by
Baccharis dracucunlifolia (GP), red propolis originated by Dalbergia ecastophylum
(RP) and tetracyclin (TC) and shaped in 6.0mm diameter discs. The antimicrobial
susceptibility test for the different discs was conducted according to CLSI (2007)
guidelines. 1.0×108 CFU/mL of Enterococcus faecalis, Streptococcus mutans,
Staphylococcus aureus were plated on Mueller-Hinton agar. The discs were placed on
the agar surface and incubated at 37°C during 48h. TC standardized discs 30mg,
Blanc stelilized discs content 20μL of GP and RP ethanolic extract, bioglass
without propolis and TC were used as controls. After incubation, the inhibition
zones were measured and reported as mean±standard deviation. Kruskal-Wallis test:
p<0.5 was considered significant. All tests were made in triplicate. The results
show that RP was more efficient and equal against three microorganisms (22.5±0.0mm)
whereas GP showed 15mm (S. aureus), 12mm (E. faecalis), 19mm (S. mutans). The GP
and RP extracts had shown similar effectiveness. The bioglass associate with Red
Propolis demonstrated to greater antimicrobial activity that observed for
tetracyclin and other controls.
AN - rayyan-563560674
AU - Bonfim, R. F. A.
AU - Chitarra, V. R.
AU - Gomes, R. T.
AU - Zacarias, R. D.
AU - Santos, V. R.
AU - Vasconcelos, W. A.
DO - 10.1055/s-0029-1234999
IS - 9
KW - propolis
glass
natural product
agar
tetracycline
biomaterial
silicon dioxide
medicinal plant
society
spectacles
ceramics
tissues
Baccharis
Dalbergia
Kruskal Wallis test
microorganism
laboratory
LA - English
PY - 2009
SN - 0006-3223
ST - Antimicrobial activity of bioactive glass associated to Brazilian red and
green propolis
T2 - Planta Med.
TI - Antimicrobial activity of bioactive glass associated to Brazilian red and
green propolis
VL - 75
ID - 14048
ER -
TY - JOUR
AB - The use of saliva as a diagnostic sample provides a non-invasive, cost-
efficient method of sample collection for disease screening without the need for
highly trained professionals. Saliva collection is far more practical and safe
compared with invasive methods of sample collection, because of the infection risk
from contaminated needles during, for example, blood sampling. Furthermore, the use
of saliva could increase the availability of accurate diagnostics for remote and
impoverished regions. However, the development of salivary diagnostics has required
technical innovation to allow stabilization and detection of analytes in the
complex molecular mixture that is saliva. The recent development of cost-effective
room temperature analyte stabilization methods, nucleic acid pre-amplification
techniques and direct saliva transcriptomic analysis have allowed accurate
detection and quantification of transcripts found in saliva. Novel protein
stabilization methods have also facilitated improved proteomic analyses. Although
candidate biomarkers have been discovered using epigenetic, transcriptomic,
proteomic and metabolomic approaches, transcriptomic analyses have so far achieved
the most progress in terms of sensitivity and specificity, and progress towards
clinical implementation. Here, we review recent developments in salivary
diagnostics that have been accomplished using genomic, transcriptomic, proteomic
and metabolomic approaches. © 2012 BioMed Central Ltd.
AN - rayyan-563560523
AU - Bonne, N. J.
AU - Wong, D. T. W.
DO - 10.1186/gm383
IS - 10
KW - alanine aminotransferase
alpha 2 macroglobulin
azurocidin
B Raf kinase
biological marker
carcinoembryonic antigen
cyclin I
DNA
endothelin receptor
epidermal growth factor
epidermal growth factor receptor 2
fibroblast growth factor receptor 2
glyceraldehyde 3 phosphate dehydrogenase
interleukin 17
interleukin 18
interleukin 1beta
interleukin 6
interleukin 8
macrophage inflammatory protein 1alpha
messenger RNA
microRNA
osteoprotegerin
protein
proteome
serum amyloid A
transcriptome
transferrin
tumor suppressor protein
vasculotropin
blood sampling
breast cancer
cancer diagnosis
capillary electrophoresis
cost effectiveness analysis
diagnostic accuracy
diagnostic imaging
diagnostic value
DNA DNA hybridization
DNA methylation
epigenetics
Epstein Barr virus
exosome
genetic marker
genomics
genotype
head and neck squamous cell carcinoma
hepatitis C
immunoblotting
infection risk
iTRAQ labeling
leukoplakia
lung cancer
metabolome
metabolomics
molecular stability
mouth squamous cell carcinoma
nasopharynx carcinoma
needle
non invasive measurement
nucleic acid amplification techniques
pancreas cancer
pancreatitis
periodontal disease
periodontitis
physical examination
precancer
priority journal
proteomics
quadrupole mass spectrometry
Raman spectrometry
reverse transcription polymerase chain reaction
reversed phase liquid chromatography
review
room temperature
saliva
saliva analysis
screening
sensitivity and specificity
surface enhanced laser desorption ionization time of flight mass spectrometry
tandem mass spectrometry
time of flight mass spectrometry
transcriptomics
tumor suppressor gene
ultra performance liquid chromatography
virus carcinogenesis
LA - English
PY - 2012
SN - 1756-994X
ST - Salivary biomarker development using genomic, proteomic and metabolomic
approaches
T2 - Genome Med.
TI - Salivary biomarker development using genomic, proteomic and metabolomic
approaches
VL - 4
ID - 13897
ER -
TY - JOUR
AB - Thermosensitive hydrogels are of great interest for in situ gelling drug
delivery. The thermosensitive vehicle with a gelation temperature in a range of 30–
36°C would be convenient to be injected as liquid and transform into gel after
injection. To prepare novel hydrogels gelling near body temperature, the gelation
temperature of poloxamer 407 (PX) were tailored by mixing PX with poly(acrylic
acid) (PAA). The gelation behaviors of PX/PAA systems as well as the interaction
mechanism were investigated by tube inversion, viscoelastic, shear viscosity, DSC,
SEM, and FTIR studies. The gelation temperature of the plain PX solutions at high
concentration of 18, 20, and 22% (w/w) gelled at temperature below 28°C, which is
out of the suitable temperature range. Mixing PX with PAA to obtain 18 and 20%
(w/w) PX with 1% (w/w) PAA increased the gelation temperature to the desired
temperature range of 30–36°C. The intermolecular entanglements and hydrogen bonds
between PX and PAA may be responsible for the modulation of the gelation features
of PX. The mixtures behaved low viscosity liquid at room temperature with shear
thinning behavior enabling their injectability and rapidly gelled at body
temperature. The gel strength increased, while the pore size decreased with
increasing PX concentration. Metronidazole, an antibiotic used for periodontitis,
was incorporated into the matrices, and the drug did not hinder their gelling
ability. The gels showed the sustained drug release characteristic. The
thermosensitive PX/PAA hydrogel could be a promising injectable in situ gelling
system for periodontal drug delivery.
AN - rayyan-563560247
AU - Boonlai, W.
AU - Tantishaiyakul, V.
AU - Hirun, N.
AU - Sangfai, T.
AU - Suknuntha, K.
DO - 10.1208/s12249-018-1010-7
IS - 5
KW - metronidazole
poloxamer
polyacrylic acid
article
body temperature
controlled study
differential scanning calorimetry
environmental temperature
gelation
heat sensitivity
high temperature
hydrogel
hydrogen bond
in vitro study
low temperature
mucoadhesion
priority journal
shear flow
shear rate
slow drug release
viscoelasticity
LA - English
PY - 2018
SN - 1530-9932
SP - 2103-2117
ST - Thermosensitive Poloxamer 407/Poly(Acrylic Acid) Hydrogels with Potential
Application as Injectable Drug Delivery System
TI - Thermosensitive Poloxamer 407/Poly(Acrylic Acid) Hydrogels with Potential
Application as Injectable Drug Delivery System
VL - 19
ID - 13621
ER -
TY - JOUR
AN - rayyan-563561604
AU - Boonrat, O.
AU - Hirun, N.
DO - 10.1007/s00289-021-03722-w
IS - 7
PY - 2022
SP - 4515-4534
ST - Micellization and gelation characteristics of different blends of pluronic
F127/methylcellulose and their use as mucoadhesive in situ gel for periodontitis
T2 - Polymer Bulletin
TI - Micellization and gelation characteristics of different blends of pluronic
F127/methylcellulose and their use as mucoadhesive in situ gel for periodontitis
85106299430&doi=10.1007%2fs00289-021-03722-
w&partnerID=40&md5=429f5ce55c337e7aebd2a3c7f97ef607
VL - 79
ID - 14978
ER -
TY - JOUR
AB - Introduction: Apical periodontitis (AP) is a common oral disease caused by
the inflammatory destruction of the periapical tissues due to the infection of the
root canal system of the tooth. It also contributes to systemic bacterial
translocation, where peripheric mononuclear blood cells (PBMCs) can act as
carriers. Toll-like receptor (TLR) 2 mediates the response to infection and
activates inflammatory responses. DNA methylation can be induced by bacteria and
contributes to the modulation of this response. Despite the evidence that supports
the participation of PBMCs in immune-inflammatory disorders, the inflammatory
profile and epigenetic regulatory mechanisms of PBMCs in AP individuals are
unknown. Aim: To determine TLR2 gene methylation and inflammatory profiles of PBMCs
in AP. Methods: Cross-sectional exploratory study. Otherwise, healthy individuals
with AP (n=27) and controls (n=30) were included. PMBCs were isolated by a Ficoll
gradient, cultured for 24 hours, and both RNA and DNA were extracted. DNA was
bisulfite-treated, and specific sites at the promoter region of the TLR2 gene were
amplified by qPCR using validated primers. To verify its amplification, agarose
gels were performed. Then, the PCR product was sequenced. mRNA expression of TLR2
was determined by qPCR. The soluble levels of 105 inflammatory mediators were first
explored with Proteome Profiler Human Cytokine Array Kit. Consequently, tumor
necrosis factor (TNF)-α, interleukin (IL)-6, IL-10, IL-6Rα, IL-1β, and IL-12p70
levels were measured by Multiplex assay. Results: PBMCs from individuals with AP
demonstrated a proinflammatory profile showing higher soluble levels of TNF-α, IL-
6, and IL-1β compared to controls (p<0.05). Higher TLR2 expression and higher
global methylation pattern of the promoter region of the gene were found in AP
compared to controls (p<0.05). The CpGs single-sites at positions -166 and -146
were completely methylated, while the site -102 was totally unmethylated,
independently of the presence of AP. DNA methylation of CpG single-sites in
positions -77 and +24 was positively associated with TLR2 expression. Conclusions:
PBMCs from AP subjects show a hyperinflammatory phenotype and TLR2 upregulation in
association with single CpG-sites’ methylation from the TLR2 gene promoter, thereby
contributing to a sustained systemic inflammatory load in individuals with
periapical endodontic diseases.
AN - rayyan-563559894
AU - Bordagaray, M. J.
AU - Fernández, A.
AU - Astorga, J.
AU - Garrido, M.
AU - Hernández, P.
AU - Chaparro, A.
AU - Lira, M. J.
AU - Gebicke-Haerter, P.
AU - Hernández, M.
DO - 10.3389/fimmu.2022.861665
KW - analyzer
densitometer
Direct
luminex
MAGPIX
methylation-specific PCR assay kit
microplate reader
microwell plate
multiplex analyzer
nucleic acid isolation kit
PCR assay kit
periodontal probe
protein array kit
reverse transcriptase PCR assay kit
spectrophotometer
sybr fast
UNC-15
CpG oligodeoxynucleotide
ficoll
hemoglobin A1c
high density lipoprotein
interleukin 10
interleukin 12p70
interleukin 1beta
interleukin 6
interleukin 6 receptor alpha
low density lipoprotein
messenger RNA
proteome
RNA 18S
triacylglycerol
adult
article
autoinflammatory disease
cell density
chemoluminescence
clinical article
clinical evaluation
controlled study
CpG island
cross-sectional study
densitometry
DNA extraction
DNA isolation
DNA methylation
female
gene amplification
gene expression
gene sequence
human
human cell
leukocyte
lipid fingerprinting
male
mononuclear cell
mRNA expression level
percussion
peripheral blood mononuclear cell
promoter region
protein expression
regulatory mechanism
RNA extraction
RNA isolation
Sanger sequencing
upregulation
DNeasy
LA - English
PY - 2022
SN - 1664-3224
ST - CpG Single-Site Methylation Regulates TLR2 Expression in Proinflammatory
PBMCs From Apical Periodontitis Individuals
T2 - Front. Immunol.
TI - CpG Single-Site Methylation Regulates TLR2 Expression in Proinflammatory
PBMCs From Apical Periodontitis Individuals
VL - 13
ID - 13268
ER -
TY - JOUR
AB - Aim. The aim of the study was to assess the effect of curcumin on the nitro-
oxidative stress in ligature-induced rat periodontitis. Methods. Periodontitis was
induced in male albino rats with a silk ligature around the inferior incisors.
Curcumin was administrated alone or with piperine. Rats were randomly assigned to
five groups (n=5): 1. PER, periodontitis; 2. OC, periodontitis plus Curcumin p.o.;
3. OCP, periodontitis plus Curcumin and Piperine p.o.; 4. OCPLC, periodontitis plus
Curcumin and Piperine p.o, and local periodontal Curcumin; 5. LC - local
periodontal Curcumin. Curcumin (1 g/kg bw) and Piperine (5mg /kg bw) were
administered p.o. daily by gavage. Local periodontal treatment with curcumin was
performed with a 2% muco-adhesive gel. Blood was collected and serum nitro-
oxidative stress was evaluated through total oxidative status (TOS), total
antioxidant capacity (TAC), total nitrites and nitrates (NOx) and oxidative stress
index (OSI). Results. The results demonstrated that orally administered curcumin,
either alone or associated with piperine significantly reduced the serum NOx, TOS
and OSI. Oral curcumin alone increased TAC. Piperine association did not cause
significant reduction of the systemic nitro-oxidative stress compared with curcumin
alone. Local curcumin did not influence significantly the serum parameters.
Conclusions. In conclusion, in rat ligature-induced periodontitis, oral
administration of curcumin was effective in reducing the systemic nitro-oxidative
stress, whereas local delivery showed no effect.
AN - rayyan-563560410
AU - Boşca, A. B.
AU - Dinte, E.
AU - Colosi, H.
AU - Ilea, A.
AU - Câmpian, R. S.
AU - UifǍlean, A.
AU - Pârvu, A. E.
KW - adhesive agent
antioxidant
curcumin
nitric acid derivative
nitrite
piperine
silk
adult
albino rat
animal experiment
animal model
animal tissue
conference abstract
controlled study
enteric feeding
incisor
male
nonhuman
oral drug administration
oxidation
oxidative stress
periodontitis
rat
LA - English
PY - 2015
SN - 2066-8872
SP - S27
ST - Curcumin effect on the nitro-oxidative stress in ligature-induced rat
periodontitis
T2 - Clujul Med.
TI - Curcumin effect on the nitro-oxidative stress in ligature-induced rat
periodontitis
VL - 88
ID - 13784
ER -
TY - JOUR
AB - Lippia sidoides Cham (Verbenaceae) is largely distributed in the northeastern
region of Brazil. It is popularly known as 'Alecrim-pimenta'. Recent studies have
shown that some species of Lippia have interesting pharmacological activities. This
study aimed to evaluate the effect of a nanostructured thymol gel (TG) 1.2 mg/g on
acute phase of ligature-induced periodontitis model [acute periodontal disease
(APD)] in rats. APD was induced in 24 Wistar rats subjected to ligature placement
on left molars in maxillae. Animals were treated with TG, immediately after APD
induction. Saline-based gel was utilized as negative control and diethylammonium
diclofenac gel 10 mg/g was used as positive control. Animals were randomly assigned
into the groups. The periodontium and the surrounding gingiva were examined at
histopathology, as well as the neutrophil influx into the gingiva was assayed using
myeloperoxidase activity levels by ELISA method. TG treatment reduced tissue lesion
at histopathology coupled to decreased myeloperoxidase activity production in
gingival tissue when compared with the saline gel control group (p < 0.05). The TG
gel was able to provide a significant myeloperoxidase decreasing in gingiva tissue
confirming to be effective in reducing gingival inflammation in this model.
AN - rayyan-563560359
AU - Botelho, M. A.
AU - Barros, G.
AU - Queiroz, D. B.
AU - Carvalho, C. F.
AU - Gouvea, J.
AU - Patrus, L.
AU - Bannet, M.
AU - Patrus, D.
AU - Rego, A.
AU - Silva, I.
AU - Campus, G.
AU - Araújo-Filho, I.
DO - 10.1002/ptr.5516
IS - 1
KW - diclofenac diethylamine
myeloperoxidase
thymol
animal cell
animal experiment
animal model
animal tissue
article
controlled study
drug efficacy
drug isolation
drug safety
drug stability
enzyme activity
Lippia
Lippia sidoides
male
neutrophil chemotaxis
nonhuman
particle size
periodontitis
plant leaf
rat
zeta potential
cataflan emulgel
LA - English
PY - 2016
SN - ["1099-1573", "0951-418X"]
SP - 152-159
ST - Nanotechnology in Phytotherapy: Antiinflammatory Effect of a Nanostructured
Thymol Gel from Lippia sidoides in Acute Periodontitis in Rats
T2 - Phytother. Res.
TI - Nanotechnology in Phytotherapy: Antiinflammatory Effect of a Nanostructured
Thymol Gel from Lippia sidoides in Acute Periodontitis in Rats
VL - 30
ID - 13733
ER -
TY - JOUR
AB - The aims of this study were to test a locally applied carvacrol gel and
determine its efficacy preventing alveolar bone loss in experimental periodontitis
in rats by regular methodology to validate applicability the atomic force
microscopy (AFM) as a novel morphology method on this model. Wistar rats were
subjected to ligature around second, upper-left molars. Animals were treated
carvacrol gel topically (CAG), immediately after Experimental Periodontitis Disease
induction for 1' three-times/day for 11 days. A vehicle gel was utilized as
control. The periodontium and the surrounding gingivae were examined at regular
histopathology and by AFM method; the neutrophil influx into the gingivae was also
assayed using myeloperoxidase activity. The bacterial flora was assessed through
culture of the gingival tissue. Alveolar bone loss was significantly inhibited by
CAG group compared to the Vehicle (V) group, the carvacrol gel treatment reduced
tissue lesion at histopathology, with preservation of the periodontium, coupled to
decreased myeloperoxidase activity in gingival tissue and also prevented the
proliferation of periodontal microorganisms and the weight loss. The GAC treatment
preserved alveolar bone resorption and showed anti-inflammatory and antibacterial
activities in experimental periodontitis. Topographical changes in histological
sections were seen bringing into high relief the periodontal structures, being a
simple and cost-effective method for periodontal evaluation with ultrastructural
resolution.
AN - rayyan-563561352
AU - Botelho, M. A.
AU - Martins, J. G.
AU - Ruela, R. S.
AU - I, R.
AU - Santos, J. A.
AU - Soares, J. B.
AU - França, M. C.
AU - Montenegro, D.
AU - Ruela, W. S.
AU - Barros, L. P.
AU - Queiroz, D. B.
AU - Araujo, R. S.
AU - Sampio, F. C.
DO - 10.1002/ptr.2798
IS - 10
J2 - Phytother Res
KW - Administration, Topical
Alveolar Bone Loss/*prevention & control
Animals
Anti-Bacterial Agents/administration & dosage/pharmacology/*therapeutic use
Anti-Inflammatory Agents/administration & dosage/pharmacology/*therapeutic use
Cymenes
Disease Models, Animal
Gels
Gingiva/*drug effects/microbiology/pathology
Ligation
Male
Microscopy, Atomic Force/methods
Molar
Monoterpenes/administration & dosage/pharmacology/*therapeutic use
Neutrophil Infiltration/drug effects
Periodontitis/*drug therapy/microbiology/pathology
Periodontium/*drug effects/pathology
Peroxidase/metabolism
Rats
Rats, Wistar
LA - eng
N1 - Laboratory of Chemistry Technology, Federal Institute of Education, Science
and Technology of Ceará, Fortaleza, Ceará, Brazil. marcobotelho1@gmail.com
PY - 2009
SP - 1439-48
ST - Protective effect of locally applied carvacrol gel on ligature-induced
periodontitis in rats: a tapping mode AFM study
T2 - Phytotherapy research : PTR
TI - Protective effect of locally applied carvacrol gel on ligature-induced
periodontitis in rats: a tapping mode AFM study
VL - 23
Y2 - 10
ID - 14726
ER -
TY - JOUR
AB - Objectives: The aim of this study was to test the efficacy of a locally
applied 8.5% nanostructured doxycycline (DOX) gel in preventing alveolar bone loss
in experimental periodontal disease (ePD) in rats by using the tapping mode atomic
force microscopy (AFM). Material and Methods: ePD was induced in 24 Wistar rats.
Animals were treated with the doxycycline gel topically, immediately after ePD
induction, and 3 times a day during 11 days. Four groups (n=6) were formed as
follows: Naïve group (animals not subjected to ePD nor treated); non-treated (NT)
group (animals subjected to ePD, but not treated); vehicle gel (VG) group (animals
subjected to ePD and treated with topical gel vehicle); and DOX group (test group):
animals subjected to ePD and treated with the 8.5% DOX gel. In order to investigate
topographical changes in histological sections, a novel simple method was used for
sample preparation, by etching sections from paraffin-embedded specimens with
xylol. Results: Comparing the AFM images, several grooves were observed on the
surface of the alveolar bone and other periodontal structures in the NT and VG
groups, with significantly greater depths when compared to the DOX group (p<0.05).
Conclusions: Periodontal structures were brought into high relief confirming to be
a simple and cost-effective method for AFM imaging with ultrastructural resolution.
The doxycycline gel was able to afford periodontal surface preservation, with
flatter grooves.
AN - rayyan-563560633
AU - Botelho, M. A.
AU - Martins, J. G.
AU - Ruela, R. S.
AU - Queiroz, D. B.
AU - Ruela, W. S.
DO - 10.1590/S1678-77572010000400003
IS - 4
doxycycline
nanosphere
peroxidase
alveolar bone loss
animal
article
atomic force microscopy
tooth cementum
comparative study
gel
gingiva
image processing
jaw
male
nanotechnology
neutrophil
pathology
periodontitis
randomization
rat
time
tooth root
Wistar rat
LA - English
PY - 2010
SN - ["1678-7757", "1678-7765"]
SP - 335-342
ST - Nanotechnology in ligature-induced periodontitis: Protective effect of a
doxycycline gel with nanoparticules
T2 - J. Appl. Oral Sci.
TI - Nanotechnology in ligature-induced periodontitis: Protective effect of a
VL - 18
ID - 14007
ER -
TY - JOUR
induction for 1′ three-times/day for 11 days. A vehicle gel was utilized as
resolution. Copyright © 2009 John Wiley & Sons, Ltd.
AN - rayyan-563560663
AU - Botelho, M. A.
AU - Martins, J. G.
AU - Ruela, R. S.
AU - Rachid, I.
AU - Santos, J. A.
AU - Soares, J. B.
AU - França, M. C.
AU - Montenegro, D.
AU - Ruela, W. S.
AU - Barros, L. P.
AU - Queiroz, D. B.
AU - Araujo, R. S.
AU - Sampio, F. C.
DO - 10.1002/ptr.2798
IS - 10
KW - carvacrol
myeloperoxidase
animal experiment
animal model
animal tissue
article
bacterial flora
controlled study
drug efficacy
drug mechanism
enzyme activity
gel
gingiva
histopathology
male
molar tooth
morphology
nonhuman
osteolysis
periodontitis
periodontium
rat
tissue injury
body weight loss
LA - English
PY - 2009
SN - ["0951-418X", "1099-1573"]
SP - 1439-1448
ST - Protective effect of locally applied carvacrol gel on ligature-induced
periodontitis in rats: A tapping mode AFM study
TI - Protective effect of locally applied carvacrol gel on ligature-induced
periodontitis in rats: A tapping mode AFM study
VL - 23
ID - 14037
ER -
TY - JOUR
induction for 1' three-times/day for 11 days. A vehicle gel was utilized as
resolution. Copyright (C) 2009 John Wiley & Sons, Ltd.
AN - rayyan-563562019
AU - Botelho, M. A.
AU - Martins, J. G.
AU - Ruela, R. S.
AU - Rachid, I.
AU - Santos, J. A.
AU - Soares, J. B.
AU - Franca, M. C.
AU - Montenegro, D.
AU - Ruela, W. S.
AU - Barros, L. P.
AU - Queiroz, D. B.
AU - Araujo, R. S.
AU - Sampio, F. C.
DO - 10.1002/ptr.2798
IS - 10
PY - 2009
SN - 0951-418X
SP - 1439-1448
ST - Protective Effect of Locally Applied Carvacrol Gel on Ligature-induced
Periodontitis in Rats: A Tapping Mode AFM Study
T2 - PHYTOTHERAPY RESEARCH
TI - Protective Effect of Locally Applied Carvacrol Gel on Ligature-induced
Periodontitis in Rats: A Tapping Mode AFM Study
VL - 23
Y2 - 10
ID - 15393
ER -
TY - JOUR
AB - In Brazilian folk medicine, Lippia sidoides (Ls) and Myracrodruon urundeuva
(Mu) have gained popularity and reputation as effective antimicrobial and anti-
inflammatory agents. This work aimed to evaluate the effect of topical herbal gel
from Ls 0.5% (v/w) and Mu 5% (w/w) in experimental periodontal disease (EPD) in
rats. Wistar rats were subjected to ligature placement around the second upper left
molars. Animals were treated topically with Ls and/or Mu-based gel, immediately
after EPD induction and three times/day for 11 days until the rats were sacrificed
(11th day). Saline-based gel was utilized as control for all experiments and
doxycycline based gel 10% (w/w) was utilized as reference substance. Animals were
weighed daily. Alveolar bone loss was measured as the difference (in millimeters)
between the cusp tip and the alveolar bone. The periodontum and the surrounding
gingivae were examined at histopathology, as well as the neutrophil influx into the
gingivae was assayed using myeloperoxidase activity and cytokine production mainly
tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) levels
by ELISA method. The local bacteria flora was assessed through culture of the
gingival tissue in standard aerobic and anaerobic media. Alveolar bone loss was
significantly inhibited by Ls and Mu combined treatment compared to the saline
control group. Ls and Mu combined treatment reduced tissue lesion at
histopathology, with partial preservation of the periodontum, coupled to decreased
myeloperoxidase activity as well as significantly inhibited TNF-alpha and IL-1 beta
production in gingival tissue compared to the saline control group. Ls and Mu
combined treatment also prevented the growth of oral microorganisms and the weight
loss. Ls and Mu combined based gel treatment preserved alveolar bone resorption and
demonstrated anti-inflammatory and antibacterial activities in experimental
periodonfitis. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
AN - rayyan-563562202
AU - Botelho, M. A.
AU - Rao, V. S.
AU - Carvalho, C. B. M.
AU - Bezerra, J. G.
AU - Fonseca, S. G. C.
AU - Vale, M. L.
AU - Montenegro, D.
AU - Cunha, F.
AU - Ribeiro, R. A.
AU - Brito, G. A.
DO - 10.1016/j.jep.2007.07.010
IS - 3
PY - 2007
SN - 0378-8741
SP - 471-478
ST - Lippia sidoides and Myracrodruon urundeuva gel prevents alveolar bone
resorption in experimental periodontitis in rats
T2 - JOURNAL OF ETHNOPHARMACOLOGY
TI - Lippia sidoides and Myracrodruon urundeuva gel prevents alveolar bone
VL - 113
Y2 - 9 y3 - 25
ID - 15576
ER -
TY - JOUR
tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) levels by ELISA method.
The local bacterial flora was assessed through culture of the gingival tissue in
standard aerobic and anaerobic media. Alveolar bone loss was significantly
inhibited by Ls and Mu combined treatment compared to the saline control group. Ls
and Mu combined treatment reduced tissue lesion at histopathology, with partial
preservation of the periodontum, coupled to decreased myeloperoxidase activity as
well as significantly inhibited TNF-α and IL-1β production in gingival tissue
compared to the saline control group. Ls and Mu combined treatment also prevented
the growth of oral microorganisms and the weight loss. Ls and Mu combined based gel
treatment preserved alveolar bone resorption and demonstrated anti-inflammatory and
antibacterial activities in experimental periodontitis. © 2007 Elsevier Ireland
Ltd. All rights reserved.
AN - rayyan-563560737
AU - Botelho, M. A.
AU - Rao, V. S.
AU - Carvalho, C. B. M.
AU - Bezerra-Filho, J. G.
AU - Vale, M. L.
AU - Montenegro, D.
AU - Cunha, F.
AU - Ribeiro, R. A.
AU - Brito, G. A.
DO - 10.1016/j.jep.2007.07.010
IS - 3
KW - herbaceous agent
interleukin 1beta
Lippia sidoides extract
myeloperoxidase
myracrodruon urundeuva extract
plant extract
sodium chloride
unclassified drug
alveolar bone
animal experiment
animal model
animal tissue
article
bacterial flora
bacterial growth
controlled study
cytokine production
enzyme activity
gel
gingiva
histopathology
Lippia sidoides
male
medicinal plant
molar tooth
mouth flora
Myracrodruon urundeuva
neutrophil
nonhuman
osteolysis
periodontal disease
rat
tissue culture
traditional medicine
body weight loss
LA - English
PY - 2007
SN - 0378-8741
SP - 471-478
T2 - J. Ethnopharmacol.
VL - 113
ID - 14111
ER -
TY - JOUR
tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) levels by
ELISA method. The local bacterial flora was assessed through culture of the
gingival tissue in standard aerobic and anaerobic media. Alveolar bone loss was
significantly inhibited by Ls and Mu combined treatment compared to the saline
control group. Ls and Mu combined treatment reduced tissue lesion at
histopathology, with partial preservation of the periodontum, coupled to decreased
myeloperoxidase activity as well as significantly inhibited TNF-alpha and IL-1beta
production in gingival tissue compared to the saline control group. Ls and Mu
combined treatment also prevented the growth of oral microorganisms and the weight
loss. Ls and Mu combined based gel treatment preserved alveolar bone resorption and
demonstrated anti-inflammatory and antibacterial activities in experimental
periodontitis.
AN - rayyan-563560984
AU - Botelho, M. A.
AU - Rao, V. S.
AU - Carvalho, C. B.
AU - Bezerra-Filho, J. G.
AU - Fonseca, S. G.
AU - Vale, M. L.
AU - Montenegro, D.
AU - Cunha, F.
AU - Ribeiro, R. A.
AU - Brito, G. A.
DO - 10.1016/j.jep.2007.07.010
IS - 3
J2 - J Ethnopharmacol
KW - Alveolar Bone Loss/*drug therapy/immunology/pathology
Anacardiaceae/*chemistry
Animals
Candida albicans/drug effects/isolation & purification
Gels/therapeutic use
Gingiva/drug effects/immunology/microbiology
Interleukin-1beta/immunology
Lippia/*chemistry
Male
Neutrophils/drug effects/immunology
Periodontitis/*drug therapy/immunology/pathology
Peroxidase/immunology
Plant Extracts/therapeutic use
Plant Oils/*therapeutic use
Rats
Rats, Wistar
Streptococcus/drug effects/isolation & purification
Tumor Necrosis Factor-alpha/immunology
LA - eng
N1 - Department of Community Health, Faculty of Medicine, Federal University of
Ceará, Rua Professor Costa Mendes, 60.430-270 Fortaleza, Ceará, Brazil.
marcobotelho1@gmail.com
PY - 2007
SN - 0378-8741 (Print)
SP - 471-8
T2 - Journal of ethnopharmacology
VL - 113
Y2 - 9 y3 - 25
ID - 14358
ER -
TY - JOUR
AB - Carvacrol and dimeric chalcones are the respective bioactive components of
Lippia sidoides and Myracrodruon urundeuva, popular medicinal plants of
Northeastern Brazil with proven antimicrobial and antiinflammatory properties.
Periodontal disease is associated with inflammation and microbiological
proliferation, thus the study aimed to investigate the effect of a topical gel
based on carvacrol and chalcones in the experimental periodontal disease (EPD) in
rats. Animals were treated with carvacrol and/or chalcones gel, immediately after
EPD induction, three times a day for 11 days. Appropriate controls were included in
the study. Animals were weighed daily. They were killed on day 11, the mandibles
dissected and alveolar bone loss was measured. The periodontium were examined at
histopathology and the neutrophil influx into the gingiva was assayed using
myeloperoxidase activity. The bacterial flora were assessed through culture of the
gingival tissue. Alveolar bone loss was significantly (p < 0.05) inhibited by
combined carvacrol and chalcones gel, compared with the vehicle and non-treated
groups. The treatment with the combined gel reduced tissue lesion at
histopathology, decreased myeloperoxidase activity in gingival tissue and inhibited
the growth of oral microorganisms as well as the weight loss. Carvacrol and
chalcones combination gel has a beneficial effect upon EPD in this model. Copyright
© 2008 John Wiley & Sons, Ltd.
AN - rayyan-563560713
AU - Botelho, M. A.
AU - Rao, V. S.
AU - Montenegro, D.
AU - Bandeira, M. A. M.
AU - Nogueira, N. A. P.
AU - Ribeiro, R. A.
AU - Brito, G. A. C.
DO - 10.1002/ptr.2325
IS - 4
KW - carvacrol
chalcone
doxycycline
myeloperoxidase
alveolar bone
animal experiment
animal model
animal tissue
article
bacterial flora
body weight
cell assay
controlled study
dissection
drug effect
enzyme activity
gel
gingiva
growth inhibition
histopathology
male
mandible
mouth flora
neutrophil
nonhuman
osteolysis
periodontitis
periodontium
rat
tissue culture
topical treatment
treatment duration
body weight loss
LA - English
PY - 2008
SN - ["0951-418X", "1099-1573"]
SP - 442-449
ST - Effects of a herbal gel containing carvacrol and chalcones on alveolar bone
resorption in rats on experimental periodontitis
TI - Effects of a herbal gel containing carvacrol and chalcones on alveolar bone
VL - 22
ID - 14087
ER -
TY - JOUR
AB - Carvacrol and dimeric chalcones are the respective bioactive components of
Lippia sidoides and Myracrodruon urundeuva, popular medicinal plants of
Northeastern Brazil with proven antimicrobial and antiinflammatory properties.
Periodontal disease is associated with inflammation and microbiological
proliferation, thus the study aimed to investigate the effect of a topical gel
based on carvacrol and chalcones in the experimental periodontal disease (EPD) in
rats. Animals were treated with carvacrol and/or chalcones gel, immediately after
EPD induction, three times a day for 11 days. Appropriate controls were included in
the study. Animals were weighed daily. They were killed on day 11, the mandibles
dissected and alveolar bone loss was measured. The periodontium were examined at
histopathology and the neutrophil influx into the gingiva was assayed using
myeloperoxidase activity. The bacterial flora were assessed through culture of the
gingival tissue. Alveolar bone loss was significantly (p < 0.05) inhibited by
combined carvacrol and chalcones gel, compared with the vehicle and non-treated
groups. The treatment with the combined gel reduced tissue lesion at
histopathology, decreased myeloperoxidase activity in gingival tissue and inhibited
the growth of oral microorganisms as well as the weight loss. Carvacrol and
chalcones combination gel has a beneficial effect upon EPD in this model.
AN - rayyan-563561126
AU - Botelho, M. A.
AU - Rao, V. S.
AU - Montenegro, D.
AU - Bandeira, M. A.
AU - Fonseca, S. G.
AU - Nogueira, N. A.
AU - Ribeiro, R. A.
AU - Brito, G. A.
DO - 10.1002/ptr.2325
IS - 4
J2 - Phytother Res
KW - Alveolar Bone Loss/*drug therapy
Animals
Bone Resorption/*drug therapy
Chalcones/*pharmacology/therapeutic use
Cymenes
Gels
Inflammation/drug therapy
Lippia/chemistry
Male
Monoterpenes/*pharmacology/therapeutic use
Periodontitis/*drug therapy
Phytotherapy
Plants, Medicinal/chemistry
Rats
Rats, Wistar
LA - eng
N1 - Department of Physiology and Pharmacology, School of Medicine, Federal
University of Ceará, Brazil. marcobotelho1@gmail.com
PY - 2008
SP - 442-9
ST - Effects of a herbal gel containing carvacrol and chalcones on alveolar bone
T2 - Phytotherapy research : PTR
TI - Effects of a herbal gel containing carvacrol and chalcones on alveolar bone
VL - 22
Y2 - 4
ID - 14500
ER -
TY - JOUR
AB - OBJECTIVES: The aim of this study was to test the efficacy of a locally
applied 8.5 percent nanostructured doxycycline (DOX) gel in preventing alveolar
bone loss in experimental periodontal disease (EPD) in rats by using the tapping
mode atomic force microscopy (AFM). MATERIAL AND METHODS: EPD was induced in 24
Wistar rats. Animals were treated with the doxycycline gel topically, immediately
after EPD induction, and 3 times a day during 11 days. Four groups (n=6) were
formed as follows: Naïve group (animals not subjected to EPD nor treated); non-
treated (NT) group (animals subjected to EPD, but not treated); vehicle gel (VG)
group (animals subjected to EPD and treated with topical gel vehicle); and DOX
group (test group): animals subjected to EPD and treated with the 8.5 percent DOX
gel. In order to investigate topographical changes in histological sections, a
novel simple method was used for sample preparation, by etching sections from
paraffin-embedded specimens with xylol. RESULTS: Comparing the AFM images, several
grooves were observed on the surface of the alveolar bone and other periodontal
structures in the NT and VG groups, with significantly greater depths when compared
to the DOX group (p<0.05). CONCLUSIONS: Periodontal structures were brought into
high relief confirming to be a simple and cost-effective method for AFM imaging
with ultrastructural resolution. The doxycycline gel was able to afford periodontal
surface preservation, with flatter grooves.
AN - rayyan-563559883
AU - Botelho, Marco Antonio
AU - Martins, Jose Galberto
AU - Ruela, Ronaldo Sousa
AU - Queiroz, Dinalva Brito
AU - Ruela, Wagner Sousa
IS - 4
KW - Atomic force microscopy
Doxycycline
Gel
Nanotechnology
Periodontitis
LA - en
PY - 2010
SN - 1678-7757
SP - 335-342
ST - Nanotechnology in ligature-induced periodontitis: protective effect of a
T2 - J. appl. oral sci
TI - Nanotechnology in ligature-induced periodontitis: protective effect of a
UR - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-
77572010000400003
VL - 18
Y2 - 8 y3 - 1
ID - 13257
ER -
TY - JOUR
AB - Introduction: The aim of this study was to correlate the bacterial viability
and the presence of 2% chlorhexidine (CHX) solution on dentin by means of confocal
laser scanning microscopy and high-performake liquid chromatography for 48 hours, 7
days, and 30 days. Methods: One hundred twenty-three extracted human teeth were
used. Samples were divided into 4 groups according to the solution (CHX or saline)
and the presence of Enterococus faecalis biofilm. Samples were kept in contact with
5 mL of the solution for 5 minutes. Each group was divided into 3 subgroups
according to the evaluation period (n = 10). Statistical analysis was performed by
using the Kruskal-Wallis test, the Mann-Whitney U test (P < .05), and the Spearman
rank correlation coefficient (P < .01). Results: There was a negative correlation
between the percentage of live cells and the amount of remaining CHX (P = .000).
CHX significantly reduced the percentage of viable cells compared with saline after
48 hours (P = .007). Differences were maintained in the 7-day evaluation period (P
= .001). After 30 days, the CHX group presented an increase of viable cells,
thereby becoming similar to saline (P = .623): Simultaneously, the remaining CHX
was significantly reduced in the 30-day specimens (P = .000). Conclusions: The
results of this study indicate that 2% CHX solution was detected for 48 hours and 7
days with a low percentage of viable cells. The presence of microorganisms on human
dentin did not affect 2% CHX maintenance.
AN - rayyan-563562643
AU - Bottcher, D. E.
AU - Sehnem, N. T.
AU - Montagner, F.
AU - Parolo, C. C. F.
AU - Grecca, F. S.
DO - 10.1016/j.joen.2015.04.016
IS - 8
PY - 2015
SN - ["0099-2399", "1878-3554"]
SP - 1364-1370
ST - Evaluation of the Effect of Enterococcus faecalis Biofilm on the 2%
Chlorhexidine Substantivity: An In Vitro Study
TI - Evaluation of the Effect of Enterococcus faecalis Biofilm on the 2%
Chlorhexidine Substantivity: An In Vitro Study
VL - 41
Y2 - 8
ID - 16017
ER -
TY - JOUR
AB - A periodontal membrane with a graded structure allows tailoring of the layer
properties to design a material system that will retain its physical, chemical and
mechanical characteristics for a period long enough to optimize periodontal
regeneration. In this work a novel functionally graded membrane (FGM) was designed
and fabricated via sequential multilayer electrospinning. The FGM consists of a
core layer (CL) and two functional surface layers (SLs) interfacing with bone
(nano-hydroxyapatite, n-HAp) and epithelial (metronidazole, MET) tissues. The CL
comprises a neat poly(dl-lactide-co - caprolactone) (PLCL) layer surrounded by two
composite layers composed of a protein/polymer ternary blend (PLCL:PLA:GEL).
Electrospinning parameters involved in fabrication of the individual layers (i.e.
neat PLCL, ternary blend, PLA:GEL + 10%n-HAp and PLA:GEL + 25%MET) were optimized
to obtain fibrous layers free of beads. Morphology, structure and mechanical
property studies were carried out on each electrospun layer. The individual fiber
morphology and roughness of the functional SLs, which are the n-HAp containing and
drug-incorporating layers were evaluated by atomic force microscopy. The CL
structure demonstrated higher strength (8.7 MPa) and a more elastic behavior
(strain at break 357%) compared with the FGM (3.5 MPa, 297%). Incorporation of n-
HAp to enhance osteoconductive behavior and MET to combat periodontal pathogens led
to a novel FGM that holds promise at solving the drawbacks of currently available
membranes. © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights
reserved.
AN - rayyan-563560610
AU - Bottino, M. C.
AU - Thomas, V.
AU - Janowski, G. M.
DO - 10.1016/j.actbio.2010.08.019
IS - 1
KW - copolymer
hydroxyapatite
metronidazole
nanomaterial
polycaprolactone
polylactic acid
polymer
article
bone
electrospinning
Fourier transform
material state
membrane
membrane structure
morphology
periodontitis
priority journal
tissue regeneration
LA - English
PY - 2011
SN - 1742-7061
SP - 216-224
ST - A novel spatially designed and functionally graded electrospun membrane for
T2 - Acta Biomater.
TI - A novel spatially designed and functionally graded electrospun membrane for
VL - 7
ID - 13984
ER -
TY - JOUR
AN - rayyan-563561936
AU - Bottino, M. C.
AU - Thomas, V.
AU - Schmidt, G.
AU - Vohra, Y. K.
AU - Chu, T. M. G.
AU - Kowolik, M. J.
DO - 10.1016/j.dental.2012.04.022
IS - 7
PY - 2012
SP - 703-721
ST - Recent advances in the development of GTR/GBR membranes for periodontal
regeneration - A materials perspective
TI - Recent advances in the development of GTR/GBR membranes for periodontal
regeneration - A materials perspective
84861837582&doi=10.1016%2fj.dental.2012.04.022&partnerID=40&md5=877e7f3f384a906261b
79f65eb4521c0
VL - 28
ID - 15310
ER -
TY - JOUR
AB - Periodontitis is a major chronic inflammatory disorder that can lead to the
destruction of the periodontal tissues and, ultimately, tooth loss. To date, flap
debridement and/or flap curettage and periodontal regenerative therapy with
membranes and bone grafting materials have been employed with distinct levels of
clinical success. Current resorbable and non-resorbable membranes act as a physical
barrier to avoid connective and epithelial tissue down-growth into the defect,
favoring the regeneration of periodontal tissues. These conventional membranes
possess many structural, mechanical, and bio-functional limitations and the "ideal"
membrane for use in periodontal regenerative therapy has yet to be developed. Based
on a graded-biomaterials approach, we have hypothesized that the next-generation of
guided tissue and guided bone regeneration (GTR/GBR) membranes for periodontal
tissue engineering will be a biologically active, spatially designed and
functionally graded nanofibrous biomaterial that closely mimics the native extra-
cellular matrix (ECM). OBJECTIVE: This review is presented in three major parts,
including (1) a brief overview of the periodontium and its pathological conditions,
(2) currently employed therapeutics used to regenerate the distinct periodontal
tissues, and (3) a review of commercially available GTR/GBR membranes as well as
the recent advances on the processing and characterization of GTR/GBR membranes
from a materials perspective. SIGNIFICANCE: Studies of spatially designed and
functionally graded membranes (FGM) and in vitro antibacterial/cell-related
research are addressed. Finally, as a future outlook, the use of hydrogels in
combination with scaffold materials is highlighted as a promising approach for
periodontal tissue engineering. Copyright © 2012 Academy of Dental Materials.
Published by Elsevier Ltd. All rights reserved.
AN - rayyan-563560541
AU - Bottino, M. C.
AU - Thomas, V.
AU - Schmidt, G.
AU - Vohra, Y. K.
AU - Chu, T. M.
AU - Kowolik, M. J.
IS - 7
KW - nanomaterial
tissue scaffold
artificial membrane
bone regeneration
chemistry
histology
human
hydrogel
devices
methodology
pathophysiology
periodontics
periodontitis
periodontium
review
tissue engineering
LA - English
PY - 2012
SN - 1879-0097
SP - 703-721
ST - Recent advances in the development of GTR/GBR membranes for periodontal
regeneration--a materials perspective
T2 - Dent Mater
TI - Recent advances in the development of GTR/GBR membranes for periodontal
regeneration--a materials perspective
VL - 28
ID - 13915
ER -
TY - JOUR
AB - Thirty hemorrhagic periodontitis adult patients completed a 90-day controlled
clinical study to determine the clinical effects of the antiinflammatory
preparation neopredin gel containing prednisolone, neomycin sulfate and
chlorhexidine when used an adjunct to scaling and root planing. The results were
evaluated using the Quigley-Hein plaque index, the Schour-Massler gingival bleeding
index, the Svrakov-Pissarev gingival vital staining index, the Muleman-Son sulcus
bleeding index and the percentage of bleeding on probing sites. Treatment with
neopredin resulted in consistently lower values of the mean plaque index score, the
gingival bleeding index score, the vital staining index score and the sulcus
bleeding index score at days 14.30 and 90. A significant reduction in the mean
pocket probing depth was observed at day 30. The first symptoms of recurrent
gingival inflammation were noticed at day 90. Our results indicate that neopredin
is effective in reducing supragingival plaque accumulation, gingival inflammation,
bleeding on probing and periodontal pocket depth and these reductions are highly
significant.
AN - rayyan-563561041
AU - Botushanov, P.
AU - Velcheva, M.
AU - Zarankova, V.
AU - Docheva, I.
AU - Mandzhukova, N.
AU - Pechlivanova, E.
AU - Tasheva, A.
IS - 1
chlorhexidine
neomycin
neopredin
prednisolone
adult
article
clinical trial
drug combination
female
gingiva bleeding
human
male
periodontics
periodontitis
LA - English
PY - 1997
SN - 0204-8043
SP - 59-64
ST - Treatment of hemorrhagic periodontitis using neopredin
T2 - Folia Med (Plovdiv)
TI - Treatment of hemorrhagic periodontitis using neopredin
VL - 39
ID - 14415
ER -
TY - JOUR
AB - CONTEXT: Periodontitis is an inflammatory disease of microbial origin.
Locally delivered antimicrobials reduce subgingival flora. Achyranthes aspera gel
has antimicrobial, antioxidant, anti-inflammatory, and immunostimulant effects.
AIMS: To evaluate the efficacy of local drug delivery of A. aspera gel in the
management of chronic periodontitis. MATERIALS AND METHODS: Thirty patients with
chronic periodontitis were considered in the study and categorized into two equal
groups (Group A: scaling and root planing (SRP) with A. aspera gel, Group B: SRP
with placebo gel). Patients were enlisted from the Department of Periodontics,
Mamata Dental College and Hospital. The clinical parameters (gingival index,
bleeding on probing, probing pocket depth, and clinical attachment level) were
recorded at baseline and 3 months. STATISTICAL ANALYSIS USED: All the obtained data
were sent for statistical analyses using SPSS version 18. RESULTS: The
periodontitis and the Achyranthes were statistically analyzed. A comparison of
clinical parameters for test group and control group from baseline to 3 months was
done using paired t-test. Intergroup comparison for both the groups was done using
independent sample t-test. CONCLUSIONS: A. aspera gel when delivered locally along
with SRP showed a beneficial effect. A. aspera gel as a non-surgical local drug
delivery system proved to be without any side effects in the management of
periodontitis. A. aspera gel has strong anti-inflammatory effects in addition to
its antioxidant activity.
AN - rayyan-563561221
AU - Boyapati, R.
AU - Gojja, P.
AU - Chintalapani, S.
AU - Nagubandi, K.
AU - Ramisetti, A.
AU - Salavadhi, S. S.
DO - 10.4103/jisp.jisp_130_17
IS - 1
J2 - J Indian Soc Periodontol
LA - eng
N1 - Department of Periodontics, Mamata Dental College, Khammam, Telangana,
India.; Department of Periodontics, Mamata Dental College, Khammam, Telangana,
India.
PY - 2017
SN - 0972-124X (Print)
SP - 46-49
ST - Efficacy of local drug delivery of Achyranthes aspera gel in the management
of chronic periodontitis: A clinical study
T2 - Journal of Indian Society of Periodontology
TI - Efficacy of local drug delivery of Achyranthes aspera gel in the management
of chronic periodontitis: A clinical study
VL - 21
Y2 - 1
ID - 14595
ER -
TY - JOUR
AB - Periodontitis is a chronic infection in the supportive tissue of the teeth
which eventually leads to tooth loss. Various grafting materials and barrier
membranes have been used to repair periodontal intraosseous lesions. Chitosan is a
derivative of chitin, a natural biopolymer, which is biologically safe,
biodegradable, and nontoxic and has been applied in a variety of forms in
dentistry. It also exerts bioactive properties such as wound healing,
antimicrobial, tissue regeneration, and hemostatic activities. The aim of this
study was to evaluate effects of chitosan on periodontal regeneration. Twenty
chronic periodontitis patients were recruited. Following initial therapy, the
patients were divided into four groups: group A, receiving chitosan gel (1% w/v);
group B, receiving chitosan gel + demineralize bone matrix; group C: receiving
chitosan gel + collagenous membrane; and group D, receiving flap only (control
group). Clinical and radiographic measurements were recorded at baseline, day 90
(3rd month), and day 180 (6th month) after surgery. For clinical data, no
significant differences were obtained among the treatment groups. However,
radiographic data revealed that except control group, all the other groups showed
statistically significant bone fills when compared with baseline indicating that
chitosan gel alone or its combination with demineralize bone matrix/collagenous
membrane is promising for periodontal regeneration. © 2009 Wiley Periodicals, Inc.
AN - rayyan-563560686
AU - Boynueǧri, D.
AU - Özcan, G.
AU - Şenel, S.
AU - Uç, D.
AU - Uraz, A.
AU - Öǧüş, E.
AU - Çakilci, B.
AU - Karaduman, B.
DO - 10.1002/jbm.b.31307
IS - 1
KW - chitosan
adult
article
bone matrix
bone mineralization
bone regeneration
clinical article
clinical evaluation
controlled study
female
human
male
periodontitis
LA - English
PY - 2009
SN - ["1552-4981", "1552-4973"]
SP - 461-466
ST - Clinical and radiographic evaluations of chitosan gel in periodontal
intraosseous defects: A pilot study
TI - Clinical and radiographic evaluations of chitosan gel in periodontal
VL - 90
ID - 14060
ER -
TY - JOUR
chitosan gel + collagenous membrane; and group D, receiving flap only (control
statistically significant bone fills when compared with baseline indicating that
membrane is promising for periodontal regeneration.
AN - rayyan-563560959
AU - Boynueğri, D.
AU - Ozcan, G.
AU - Senel, S.
AU - Uç, D.
AU - Uraz, A.
AU - Oğüş, E.
AU - Cakilci, B.
AU - Karaduman, B.
DO - 10.1002/jbm.b.31307
IS - 1
KW - Adult
Bone and Bones/*pathology
Chitosan/*administration & dosage
Female
Gels
Humans
Male
Middle Aged
Periodontium/*pathology
Pilot Projects
LA - eng
N1 - Department of Periodontology, Faculty of Dentistry, Gazi University, Ankara,
Turkey. duygu_db@yahoo.com
PY - 2009
SP - 461-6
intraosseous defects: a pilot study
intraosseous defects: a pilot study
VL - 90
Y2 - 7
ID - 14333
ER -
TY - JOUR
AN - rayyan-563562095
AU - Boynueǧri, D.
AU - Özcan, G.
AU - Şenel, S.
AU - Uç, D.
AU - Uraz, A.
AU - Öǧüş, E.
AU - Çakilci, B.
AU - Karaduman, B.
DO - 10.1002/jbm.b.31307
IS - 1
PY - 2009
SP - 461-466
67650838489&doi=10.1002%2fjbm.b.31307&partnerID=40&md5=cf93d34101ac88b33525682ea918
071c
VL - 90
ID - 15469
ER -
TY - JOUR
chitosan gel + collagenous membrane; and group D, receiving nap only (control
statistically significant bone rills when compared with baseline indicating that
membrane is promising for periodontal regeneration. (c) 2009 Wiley Periodicals,
Inc. J Biomed Mater Res Part B: Appl Biomater 90B: 461-466, 2009
AN - rayyan-563562190
AU - Boynuegri, D.
AU - Ozcan, G.
AU - Senel, S.
AU - Uc, D.
AU - Uraz, A.
AU - Ogus, E.
AU - Cakilci, B.
AU - Karaduman, B.
DO - 10.1002/jbm.b.31307
IS - 1
PY - 2009
SN - ["1552-4973", "1552-4981"]
SP - 461-466
ST - Clinical and Radiographic Evaluations of Chitosan Gel in Periodontal
Intraosseous Defects: A Pilot Study
TI - Clinical and Radiographic Evaluations of Chitosan Gel in Periodontal
Intraosseous Defects: A Pilot Study
VL - 90
Y2 - 7
ID - 15564
ER -
TY - JOUR
AB - Background and Objective: Simvastatin, a cholesterol-lowering drug, also
stimulates oral bone growth when applied topically, without systemic side-effects.
However, the mechanisms involved in vivo are not known. We hypothesized that bone
morphogenetic protein-2, nitric oxide synthase, and cyclooxygenase-2 are involved,
based on prior in vitro evidence. Material and Methods: A rat bilateral mandible
model, where 0.5 mg of simvastatin in methylcellulose gel was placed on one side
and gel alone on the other, was used to quantify nitric oxide, cyclooxygenase-2 and
bone morphogenetic protein-2 (via tissue extraction, enzyme activity or
immunoassay), and to analyze the bone formation rate (via undecalcified
histomorphometry). Cyclooxygenase-2 and nitric oxide synthase inhibitors (NS-398
and L-NAME, respectively) were administered intraperitoneally. Results: Simvastatin
was found to stimulate local bone morphogenetic protein-2, nitric oxide and the
regional bone formation rate (p < 0.05), whereas NS-398 inhibited bone
morphogenetic protein-2 and reduced the bone formation rate (p < 0.05). Conclusion:
These data suggest an association between simvastatin-induced bone morphogenetic
protein-2 and bone formation in the mandibular microenvironment, and the negative
effect of cyclooxygenase-2 inhibitors on bone growth. © 2007 Blackwell Munksgaard.
AN - rayyan-563560744
AU - Bradley, J. D.
AU - Cleverly, D. G.
AU - Burns, A. M.
AU - Helm, N. B.
AU - Schmid, M. J.
AU - Marx, D. B.
AU - Cullen, D. M.
AU - Reinhardt, R. A.
DO - 10.1111/j.1600-0765.2006.00943.x
IS - 3
KW - bone morphogenetic protein
cyclooxygenase 2
cyclooxygenase 2 inhibitor
enzyme inhibitor
hypocholesterolemic agent
n (2 cyclohexyloxy 4 nitrophenyl)methanesulfonamide
n(g) nitroarginine methyl ester
nitric oxide synthase
nitrobenzene derivative
simvastatin
sulfonamide
animal
article
bone development
drug effect
metabolism
rat
LA - English
PY - 2007
SN - 0022-3484
SP - 267-273
ST - Cyclooxygenase-2 inhibitor reduces simvastatin-induced bone morphogenetic
protein-2 and bone formation in vivo
TI - Cyclooxygenase-2 inhibitor reduces simvastatin-induced bone morphogenetic
protein-2 and bone formation in vivo
VL - 42
ID - 14118
ER -
TY - JOUR
AB - Thermogelling amphiphilic block copolymers have been widely investigated in
the development of pharmaceutical drug carriers. In particular, thermosensitive
gels based on poloxamer 407 (P407) have great potential for periodontal disease
treatment, thanks to their ability to be liquid at room temperature and become
viscous gels at body temperature. However, some problems, related to short in situ
residence time, reduce their feasible clinical use. Thus, in order to improve the
effective applicability of these materials, we studied how P407 thermogels are
affected by the pH and by the inclusion of different hydrophilic polymers, used as
excipients for increasing the gel stiffness. For this scope, a complete chemical-
physical characterization of the synthesized gels is provided, in terms of
determination of sol-gel transition temperature, viscosity and erosion degree. The
data are correlated according to a statistical multivariate approach based on
Principal Component Analysis and their mucoadhesion properties are also tested by
Tapping mode-Atomic Force Microscopy (TM-AFM) imaging. Finally, we studied how the
different P407 formulations are able to influence the release pathway of two
antibacterial drugs (i.e., chlorhexidine digluconate and doxycycline hyclate)
largely used in oral diseases.
AN - rayyan-563561334
AU - Brambilla, E.
AU - Locarno, S.
AU - Gallo, S.
AU - Orsini, F.
AU - Pini, C.
AU - Farronato, M.
AU - Thomaz, D. V.
AU - Lenardi, C.
AU - Piazzoni, M.
AU - Tartaglia, G.
DO - 10.3390/polym14173624
IS - 17
J2 - Polymers (Basel)
LA - eng
N1 - Department of Pharmaceutical Sciences, Section of General and Organic
Chemistry Section "A. Marchesini", University of Milan, 20133 Milan, Italy.;
Department of Physics "Aldo Pontremoli", University of Milan, 20133 Milan, Italy.;
Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20100
Milan, Italy.; National Enterprise for NanoScience and NanoTechnology (NEST),
Istituto Nanoscienze-CNR and Scuola Normale Superiore, Piazza San Silvestro 12,
56127 Pisa, Italy.; Department of Physics "Aldo Pontremoli", University of Milan,
20133 Milan, Italy.; Department of Biomedical, Surgical and Dental Sciences,
University of Milan, 20100 Milan, Italy.; Department of Biomedical, Surgical and
Dental Sciences, University of Milan, 20100 Milan, Italy.
PY - 2022
ST - Poloxamer-Based Hydrogel as Drug Delivery System: How Polymeric Excipients
Influence the Chemical-Physical Properties
T2 - Polymers
TI - Poloxamer-Based Hydrogel as Drug Delivery System: How Polymeric Excipients
Influence the Chemical-Physical Properties
VL - 14
Y2 - 9 y3 - 1
ID - 14708
ER -
TY - JOUR
AB - Introduction: In order to prevent ostenecrosis in patient undergoing
bisphosphonate therapy, FDA developed a protocol for the dental treatment. There
are no precise recommendations whether root canal treatment is indicated if there
is extensive periapical lesion. Case report: The paper presents root canal
treatment of 36 tooth with apical periodontitis and sinus tract, of 39 years old
patient with long-term bisphosphonate therapy and complex health problems: Sy.
Sjogren, osteoporosis, hypothyreosis, temporomandibular joint dysfunction. The
modification of root canal treatment emerged as consequences of: 1. Increased risk
of osteonecrosis as result of long-term bisphosphonates therapy, 2. Impossible
rubber-dam placement due to constant cough caused by Sy.Sjogren, resulting in risk
of mucous irritation with irrigants, 3. Temporomandibular dysfunction requiring
shortening of work in one session, 4. Modification of the inter-seance canal
medication due to cyto-therapy that patient receives simultaneously, 5. Significant
obstruction of the root canals established during the treatment. For the above
reasons, the appointments duration were achieved using single-file technique,
adequate chemical treatment with 5.25% NaOCl gel (without the risk of mucosal
irritation) and intracanal medication by combination of Ca(OH)2 and chlorhexidine.
Control image showed satisfactory signs of apical healing. The final success
evaluation requires extended observation period, due to possibility of subsequent
osteonecrosis associated with bisphosphonate therapy. Conclusion: The number of
patients on bisphosphonate therapy increases daily with simultaneously decrease of
age limit for osteoporotic changes. This requires serious clinical research and the
development of more precise endodontic protocols.
AN - rayyan-563560280
AU - Brankovic, L. H.
AU - Šaban, A.
AU - Tahmišcija, I.
AU - Korac, S.
AU - Džankovic, A.
IS - 4
KW - bisphosphonic acid derivative
calcium hydroxide
chlorhexidine
hypochlorite sodium
adult
bone necrosis
case report
clinical article
clinical research
cofferdam
comorbidity
conference abstract
coughing
dental procedure
drug combination
drug therapy
female
human
hypothyroidism
male
mucosa
obstruction
osteoporosis
prevention
side effect
temporomandibular joint disorder
tooth root canal
LA - ["English", "Bosnian"]
PY - 2017
SN - 1846-0410
SP - 369
ST - Root canal treatment patient with long-term bisphosphonate therapy and severe
comorbidity
T2 - Endodontski Tretman Pacijenta Na Dugogodišnjoj Bisfosfonatnoj Terapiji I
Ozbiljnim Komorbiditetom
TI - Root canal treatment patient with long-term bisphosphonate therapy and severe
comorbidity
VL - 51
ID - 13654
ER -
TY - JOUR
AB - Gingival diseases are the most widely held diseases in America. In some
patients, periodontal disease appears in a generalized form, but more often it
appears in localized areas. Furthermore, after treatment with scaling and root
planing (SRP) in generalized cases, the disease is often reduced to a few local
areas in the patient's mouth. Since periodontitis is a bacterial infection with
known pathogenic microorganisms, the local delivery of antimicrobials has been
considered to be a possible solution for treating and controlling localized forms
of periodontal disease. Three current local chemotherapeutic agents are reviewed in
this paper: doxycycline gel, chlorhexidine chip and minocycline microspheres. With
the advancement of local drug delivery systems, clinicians and their patients have
new alternatives for treatment of periodontal disease.
AN - rayyan-563560853
AU - Breault, L. G.
AU - Spadar, S. E.
IS - 6
KW - chlorhexidine
doxycycline
drug carrier
minocycline
article
drug combination
gel
human
periodontitis
LA - English
PY - 2004
SN - 1088-3886
SP - 20, 22-24, 63
ST - Local chemotherapeutics as an adjunct to scaling and root planing
T2 - Dent Assist
TI - Local chemotherapeutics as an adjunct to scaling and root planing
VL - 73
ID - 14227
ER -
TY - JOUR
AB - Formulations containing poloxamer 407 (P407), carbopol 934P (C934P), and
propolis extract (PE) were designed for the treatment of periodontal disease.
Gelation temperature, in vitro drug release, rheology, hardness, compressibility,
adhesiveness, mucoadhesion, and syringeability of formulations were determined.
Propolis release from formulations was controlled by the phenomenon of relaxation
of polymer chains. Formulations exhibited pseudoplastic flow and low degrees of
thixotropy or rheopexy. In most samples, increasing the concentration of C934P
content significantly increased storage modulus (G′), loss modulus (G″), and
dynamic viscosity (η′), at 5°C, G″ exceeded G′. At 25 and 37°C, η′ of each
formulation depended on the oscillatory frequency. Formulations showed
thermoresponsive behavior, existing as a liquid at room temperature and gel at 34-
37°C. Increasing the C934P content or temperature significantly increased
formulation hardness, compressibility, and adhesiveness. The greatest mucoadhesion
was noted in the formulation containing 15% P407 (w/w) and 0.25% C934P (w/w). The
work of syringeability values of all formulations were similar and very desirable
with regard to ease of administration. The data obtained in these formulations
indicate a potentially useful role in the treatment of periodontitis and suggest
they are worthy of clinical evaluation. © 2007 Wiley-Liss, Inc. and the American
Pharmacists Association.
AN - rayyan-563560741
AU - Bruschi, M. L.
AU - Jones, D. S.
AU - Panzeri, H.
AU - Gremião, M. P. D.
AU - De Freitas, O.
AU - Lara, E. H. G.
DO - 10.1002/jps.20843
IS - 8
KW - c 934p
carbomer
p 407
poloxamer
propolis
unclassified drug
article
controlled study
drug formulation
drug release
human
oscillation
periodontal disease
physical chemistry
shear rate
shear stress
thixotropy
LA - English
PY - 2007
SN - ["0022-3549", "1520-6017"]
SP - 2074-2089
ST - Semisolid systems containing propolis for the treatment of periodontal
disease: In vitro release kinetics, syringeability, rheological, textural, and
mucoadhesive properties
T2 - J. Pharm. Sci.
TI - Semisolid systems containing propolis for the treatment of periodontal
VL - 96
ID - 14115
ER -
TY - JOUR
AB - Formulations containing poloxamer 407 (P407), carbopol 934P (C934P), and
propolis extract (PE) were designed for the treatment of periodontal disease.
Gelation temperature, in vitro drug release, rheology, hardness, compressibility,
adhesiveness, mucoadhesion, and syringeability of formulations were determined.
Propolis release from formulations was controlled by the phenomenon of relaxation
of polymer chains. Formulations exhibited pseudoplastic flow and low degrees of
thixotropy or rheopexy. In most samples, increasing the concentration of C934P
content significantly increased storage modulus (G'), loss modulus (G ''), and
dynamic viscosity (n') at 5 degrees C, G '' exceeded G'. At 25 and 37 degrees C, n'
of each formulation depended on the oscillatory frequency. Formulations showed
thermoresponsive behavior, existing as a liquid at room temperature and gel at 34-
37 degrees C. Increasing the C934P content or temperature significantly increased
formulation hardness, compressibility, and adhesiveness. The greatest mucoadhesion
was noted in the formulation containing 15% P407 (w/w) and 0.25% C934P (w/w). The
work of syringeability values of all formulations were similar and very desirable
with regard to ease of administration. The data obtained in these formulations
indicate a potentially useful role in the treatment of periodontitis and suggest
they are worthy of clinical evaluation. (c) 2007 Wiley-Liss, Inc.
AN - rayyan-563562474
AU - Bruschi, M. L.
AU - Jones, D. S.
AU - Panzeri, H.
AU - Gremiao, M. P. D.
AU - De Freitas, O.
AU - Lara, E. H. G.
DO - 10.1002/jps.20843
IS - 8
PY - 2007
SN - ["0022-3549", "1520-6017"]
SP - 2074-2089
ST - Semisolid systems containing propolis for the treatment of periodontal
T2 - JOURNAL OF PHARMACEUTICAL SCIENCES
TI - Semisolid systems containing propolis for the treatment of periodontal
VL - 96
Y2 - 8
ID - 15848
ER -
TY - JOUR
AB - Placing antimicrobial treatments directly in periodontal pockets is an
example of the local administration of antimicrobial drugs to treat periodontitis.
This method of therapy is advantageous since the drug concentration after
application far surpasses the minimum inhibitory concentration (MIC) and lasts for
a number of weeks. As a result, numerous local drug delivery systems (LDDSs)
utilizing various antibiotics or antiseptics have been created. There is constant
effort to develop novel formulations for the localized administration of
periodontitis treatments, some of which have failed to show any efficacy while
others show promise. Thus, future research should focus on the way LDDSs can be
personalized in order to optimize future clinical protocols in periodontal therapy.
AN - rayyan-563559708
AU - Budală, D. G.
AU - Luchian, I.
AU - Tatarciuc, M.
AU - Butnaru, O.
AU - Armencia, A. O.
AU - Virvescu, D. I.
AU - Scutariu, M. M.
AU - Rusu, D.
DO - 10.3390/jcm12124137
IS - 12
KW - antimicrobial therapy
clinical protocol
mouth disease
periodontal disease
periodontal pocket
periodontics
periodontitis
review
antibiotic agent
antiinfective agent
hydrogel
nanoparticle
LA - English
PY - 2023
SN - 2077-0383
ST - Are Local Drug Delivery Systems a Challenge in Clinical Periodontology?
T2 - J. Clin. Med.
TI - Are Local Drug Delivery Systems a Challenge in Clinical Periodontology?
VL - 12
ID - 13082
ER -
TY - JOUR
AB - The aim of the present study was to evaluate the clinical and microbiological
effects of subgingival application of 25% metronidazole dental gel as an adjunct to
scaling and root planing (SRP) in the treatment of adult periodontitis. Eighty
teeth in 18 patients were evaluated using a split mouth design. The test teeth
received SRP and a 25% metronidazole gel applied subgingivally on days 0 and 7. The
control teeth received SRP only. Clinical and microbiological examinations were
carried out before treatment and on weeks 1, 3, 7, 13, 26, 38 and 52 of the
experimental period. Colony forming units of Porphyromonas gingivalis and
Prevotella intermedia / Prevotella nigrescens were determined. Both treatments
provided significant improvements in all the clinical and microbiological
parameters (P<0.05). However, none of the differences between the study groups were
statistically significant (P > 0.05). As a conclusion, the present study does not
provide evidence in favour of the routine use of adjunctive metronidazole dental
gel in the treatment of adult periodontitis.
AN - rayyan-563560920
AU - Buduneli, E.
AU - Tünger, A.
AU - Evrenosoglu, E.
AU - Bilgiç, A.
IS - 4
metronidazole
adult
article
bacterial count
clinical trial
comparative study
controlled study
drug effect
female
follow up
gel
gingiva bleeding
human
male
microbiology
middle aged
periodontal disease
periodontitis
Prevotella
statistics
LA - English
PY - 2001
SN - 1466-2094
SP - 81-86
ST - Comparative clinical and microbiological effects of subgingival metronidazole
application in adult periodontitis; 12-months results
TI - Comparative clinical and microbiological effects of subgingival metronidazole
application in adult periodontitis; 12-months results
VL - 3
ID - 14294
ER -
TY - JOUR
AB - Natural products are well-known due to their antimicrobial properties. This
study aimed to evaluate the antimicrobial effect of Desplac® product (composed of
Aloe Vera, Propolis Extract, Green Tea, Cranberry, and Calendula) on the
subgingival biofilm. Two different protocols were used to treat the 33-species
biofilms: (A) 2×/day (12/12 h) for 1 min with Desplac® or Noplak Toothpaste
(Chlorhexidine + Cetylpyridinium Chloride) or Oral B ProGengiva (stannous Fluoride)
or a placebo gel; (B) a 12-h use of the Desplac® product or 0.12% chlorhexidine gel
or a placebo gel. After 7 days of biofilm formation, the metabolic activity (MA)
and biofilm profile were determined by 2,3,5-triphenyltetrazolium chloride and
Checker-board DNA–DNA hybridization, respectively. Statistical analysis used the
Kruskal-Wallis test followed by Dunn’s post-hoc. In protocol A, all treatments
presented reduced MA compared to the placebo (p ≤ 0.05). The Desplac®-treated
biofilm showed a similar microbial profile to other antimicrobials, although with
higher bacterial total counts. In protocol B, MA of Desplac®-treated biofilms was
lower than the placebo’s MA but higher than chlorhexidine-treated biofilms (p ≤
0.05). Pathogen levels in Desplac®-treated biofilms were lower than in placebo-
treated biofilms and elevated compared to the chlorhexidine-treated biofilms (p ≤
0.05). Desplac® inhibited the biofilm development and disrupted the mature
subgingival biofilm, highlighting its effect on Tannerella forsythia counts.
AN - rayyan-563559770
AU - Bueno-Silva, B.
AU - Kiausinus, K. R.
AU - Gonçalves, F. J. D. S.
AU - Moreira, M. V. C.
AU - Oliveira, E. G. D.
AU - Brugnera Junior, A.
AU - Feres, M.
AU - Figueiredo, L. C.
DO - 10.3389/fmicb.2023.1122051
KW - culture medium
cetylpyridinium salt
chlorhexidine
digoxigenin
gel
placebo
propolis extract
stannous fluoride
toothpaste
triphenyltetrazolium
Actinomyces gerencseriae
Actinomyces israelii
Actinomyces naeslundii
Actinomyces odontolyticus
Aloe vera
article
bacterial growth
biofilm
Calendula
Campylobacter gracilis
Campylobacter showae
Capnocytophaga gingivalis
Capnocytophaga ochracea
Capnocytophaga sputigena
cranberry
Eikenella corrodens
Eubacterium nodatum
Eubacterium saburreum
Fusobacterium nucleatum polymorphum
Fusobacterium periodonticum
Gemella morbillorum
Kruskal Wallis test
nonhuman
Parvimonas micra
periodontal disease
post hoc analysis
Prevotella
Propionibacterium acnes
Selenomonas noxia
Streptococcus anginosus
Streptococcus constellatus
Streptococcus intermedius
Streptococcus mitis
Streptococcus oralis
tea
Veillonella parvula
LA - English
PY - 2023
SN - 1664-302X
ST - Antimicrobial activity of Desplac® oral gel in the subgingival multispecies
biofilm formation
TI - Antimicrobial activity of Desplac® oral gel in the subgingival multispecies
biofilm formation
VL - 14
ID - 13144
ER -
TY - JOUR
study aimed to evaluate the antimicrobial effect of Desplac (R) product (composed
of Aloe Vera, Propolis Extract, Green Tea, Cranberry, and Calendula) on the
biofilms: (A) 2x/day (12/12 h) for 1 min with Desplac (R) or Noplak Toothpaste
or a placebo gel; (B) a 12-h use of the Desplac (R) product or 0.12% chlorhexidine
gel or a placebo gel. After 7 days of biofilm formation, the metabolic activity
(MA) and biofilm profile were determined by 2,3,5-triphenyltetrazolium chloride and
Checker-board DNA-DNA hybridization, respectively. Statistical analysis used the
Kruskal-Wallis test followed by Dunn's post-hoc. In protocol A, all treatments
presented reduced MA compared to the placebo (p <= 0.05). The Desplac (R)-treated
higher bacterial total counts. In protocol B, MA of Desplac (R)-treated biofilms
was lower than the placebo's MA but higher than chlorhexidine-treated biofilms (p
<= 0.05). Pathogen levels in Desplac (R)-treated biofilms were lower than in
placebo-treated biofilms and elevated compared to the chlorhexidine-treated
biofilms (p <= 0.05). Desplac (R) inhibited the biofilm development and disrupted
the mature subgingival biofilm, highlighting its effect on Tannerella forsythia
counts.
AN - rayyan-563562283
AU - Goncalves, F. J. D.
AU - de Oliveira, E. G.
AU - Brugnera, A.
AU - Feres, M.
DO - 10.3389/fmicb.2023.1122051
PY - 2023
SN - 1664-302X
ST - Antimicrobial activity of Desplac (R) oral gel in the subgingival
multispecies biofilm formation
T2 - FRONTIERS IN MICROBIOLOGY
TI - Antimicrobial activity of Desplac (R) oral gel in the subgingival
multispecies biofilm formation
VL - 14
Y2 - 5 y3 - 16
ID - 15657
ER -
TY - JOUR
study aimed to evaluate the antimicrobial effect of Desplac® product (composed of
Aloe Vera, Propolis Extract, Green Tea, Cranberry, and Calendula) on the
biofilms: (A) 2×/day (12/12 h) for 1 min with Desplac® or Noplak Toothpaste
or a placebo gel; (B) a 12-h use of the Desplac® product or 0.12% chlorhexidine gel
or a placebo gel. After 7 days of biofilm formation, the metabolic activity (MA)
and biofilm profile were determined by 2,3,5-triphenyltetrazolium chloride and
Checker-board DNA-DNA hybridization, respectively. Statistical analysis used the
Kruskal-Wallis test followed by Dunn's post-hoc. In protocol A, all treatments
presented reduced MA compared to the placebo (p ≤ 0.05). The Desplac®-treated
higher bacterial total counts. In protocol B, MA of Desplac®-treated biofilms was
lower than the placebo's MA but higher than chlorhexidine-treated biofilms (p ≤
0.05). Pathogen levels in Desplac®-treated biofilms were lower than in placebo-
treated biofilms and elevated compared to the chlorhexidine-treated biofilms (p ≤
0.05). Desplac® inhibited the biofilm development and disrupted the mature
subgingival biofilm, highlighting its effect on Tannerella forsythia counts.
AN - rayyan-563560987
AU - Gonçalves, Fjds
AU - de Oliveira, E. G.
AU - Brugnera Junior, A.
AU - Feres, M.
DO - 10.3389/fmicb.2023.1122051
J2 - Front Microbiol
LA - eng
N1 - Dental Research Division, Guarulhos University, Guarulhos, Brazil.; Dental
Research Division, Guarulhos University, Guarulhos, Brazil.; Dental Research
Division, Guarulhos University, Guarulhos, Brazil.; Dental Research Division,
Guarulhos University, Guarulhos, Brazil.; Sysplac Produtos Médicos e Odontológicos
LTDA, São Paulo, Brazil.; Education College of the European Master in Oral Laser
Application (EMDOLA), University of Liège, Liège, Belgium.; Research Collaborator
at the IFSC-University of São Paulo (USP), São Paulo, Brazil.; Dental Research
Division, Guarulhos University, Guarulhos, Brazil.; Dental Research Division,
Guarulhos University, Guarulhos, Brazil.
PY - 2023
SN - 1664-302X (Print)
SP - 1122051
ST - Antimicrobial activity of Desplac® oral gel in the subgingival multispecies
biofilm formation
T2 - Frontiers in microbiology
TI - Antimicrobial activity of Desplac® oral gel in the subgingival multispecies
biofilm formation
VL - 14
ID - 14361
ER -
TY - JOUR
AB - Subgingival plaque samples obtained from 25 patients with chronic
inflammatory periodontal disease were exposed in vitro to a commercial dental gel
formulation containing two amine fluorides. High dilutions (1 in 32) of the gel
inhibited the growth of all cultivable bacteria in all of the samples. Lower
concentrations of gel were still effective, with a 1 in 128 dilutions of gel,
corresponding to an amine fluoride concentration of 260 mg/l, inhibiting 97.5% of
the bacteria in the samples.
AN - rayyan-563561177
AU - Bullock, S.
AU - Newman, H. N.
AU - Wilson, M.
IS - 1
KW - aminofluoride
elmex
adult
aged
bacterium isolation
clinical article
female
growth inhibition
human
in vitro study
male
nonhuman
periodontitis
priority journal
LA - English
PY - 1989
SN - 0305-7453
SP - 59-67
ST - The in-vitro effect of an amine fluoride gel on subgingival plaque bacteria
T2 - J. ANTIMICROB. CHEMOTHER.
TI - The in-vitro effect of an amine fluoride gel on subgingival plaque bacteria
VL - 23
ID - 14551
ER -
TY - JOUR
AB - The antimicrobial resistance (AMR) phenomenon is an emerging global problem
and is induced by overuse and misuse of antibiotics in medical practice. In total,
10% of antibiotic prescriptions are from dentists, usually to manage oro-dental
pains and avoid postsurgical complications. Recent research and clinical
evaluations highlight new therapeutical approaches with a reduction in dosages and
number of antibiotic prescriptions and recommend focusing on an accurate diagnosis
and improvement of oral health before dental treatments and in patients' daily
lives. In this article, the most common clinical and operative situations in dental
practice, such as endodontics, management of acute alveolar abscesses, extractive
oral surgery, parodontology and implantology, are recognized and summarized,
suggesting possible guidelines to reduce antibiotic prescription and consumption,
maintaining high success rates and low complications rates. Additionally, the
categories of patients requiring antibiotic administration for pre-existing
conditions are recapitulated. To reduce AMR threat, it is important to establish
protocols for treatment with antibiotics, to be used only in specific situations.
Recent reviews demonstrate that, in dentistry, it is possible to minimize the use
of antibiotics, thoroughly assessing patient's conditions and type of intervention,
thus improving their efficacy and reducing the adverse effects and enhancing the
modern concept of personalized medicine.
AN - rayyan-563562599
AU - Buonavoglia, A.
AU - Leone, P.
AU - Solimando, A. G.
AU - Fasano, R.
AU - Malerba, E.
AU - Prete, M.
AU - Corrente, M.
AU - Prati, C.
AU - Vacca, A.
AU - Racanelli, V.
DO - 10.3390/antibiotics10050550
IS - 5
PY - 2021
SN - 2079-6382
ST - Antibiotics or No Antibiotics, That Is the Question: An Update on Efficient
and Effective Use of Antibiotics in Dental Practice
T2 - ANTIBIOTICS-BASEL
TI - Antibiotics or No Antibiotics, That Is the Question: An Update on Efficient
and Effective Use of Antibiotics in Dental Practice
VL - 10
Y2 - 5
ID - 15973
ER -
TY - JOUR
AB - The hypothesis that the collagen in the periodontal membrane forms a
thixotropic gel in life and that the arrangement seen in histological preparations
is a fixation artifact was tested by comparing the effects of various agents on the
position of teeth in isolated unfixed mandibles and on the length of bundles of rat
tail tendon collagen. Changing from Ringer solution to deionized water produced a
reversible shortening of fibres and extrusion of teeth. Sucrose solutions produced
irreversible lengthening and intrusion. Glutaraldehyde generally produced no length
changes in the fibres or movements of the teeth but made both the fibres and teeth
unresponsive to further changes of solution. Six mandibles in Ringer solution were
heated in 5 degrees C increments to 70 degrees C. Between 60 and 65 degrees C
(denaturation temperature of soft tissue collagens) the incisor extruded by 60 +/-
15 (SD) micron. This extrusion did not occur in mandibles that had been stored in
formalin. These results are consistent with at least part of the periodontal
collagen existing as obliquely oriented fibres before fixation. This orientation is
such that contraction of the fibres could produce an eruptive force.
AN - rayyan-563561191
AU - Burn-Murdoch, R. A.
AU - Tyler, D. W.
IS - 12
KW - collagen
glutaraldehyde
sucrose
animal
article
drug effect
histology
incisor
male
mandible
metabolism
periodontium
rat
rat strain
temperature
LA - English
PY - 1981
SN - 0003-9969
SP - 995-999
ST - Physiological evidence that periodontal collagen in the rat exists as fibres
prior to histological fixation
T2 - Arch. Oral Biol.
TI - Physiological evidence that periodontal collagen in the rat exists as fibres
prior to histological fixation
VL - 26
ID - 14565
ER -
TY - JOUR
AB - Introduction: Host-microbiome interactions play an important part in
regulating human health. Microbiomes consist of up to 200 different species of
bacteria. Whereas commensal oral microbiomes do not damage the host tissue,
pathogenic oral microbiomes cause diseases such as gingivitis or caries. Aim: The
aim of this study was to determine the host response to commensal and pathogenic
oral microbiomes with the aid of full thickness tissue engineered gingiva
equivalents (GE). Methods: The GE consisted of a fully differentiated epithelium on
a fibroblast populated collagen hydrogel. Three distinct oral microbiomes were
grown, resembling a commensal, gingivitis and cariogenic phenotype. GE were exposed
to the microbiomes for 24 hours. GE response to the different microbiomes was
analyzed by histology and inflammatory mediator release (ELISA). Results: A dense
layer of commensal, gingivitis or cariogenic bacteria were observed on GE tissue
sections. Commensal and cariogenic bacteria had no detrimental effects on GE
histology. However gingivitis bacteria caused a disruption in tissue integrity in
the upper epithelial layers. Notable differences were observed in the secretion of
inflammatory cytokines. IL-6, CXCL8 and CCL20 secretion was higher when the GE were
exposed to commensal microbiomes than to pathogenic microbiomes. In contrast, CCL5
upregulation was similar for all three microbiomes. Conclusions: Commensal
microbiomes and pathogenic microbiomes induce a different inflammatory
cytokineresponse in gingiva tissue. Notably, GE secreted higher amounts of pro-
inflammatory cytokines in response to the commensal microbiome than in response to
the pathogenic microbiome. Our results indicate that the pathogenic microbiome
might actively evade the immune response.
AN - rayyan-563560321
AU - Buskermolen, J. K.
AU - Janus, M. M.
AU - Krom, B. P.
AU - Gibbs, S.
IS - 1
KW - collagen
endogenous compound
interleukin 6
interleukin 8
RANTES
commensal
conference abstract
epithelium
fibroblast
gingival tissue
gingivitis
histology
human
human tissue
hydrogel
immune response
mediator release
microbiome
nonhuman
phenotype
thickness
tissue section
upregulation
LA - English
PY - 2017
SN - 0925-8604
SP - 30
ST - Response of gingiva equivalents to commensal and pathogenic oral microbiomes
T2 - Ned. Tijdschr. Dermatol. Venereol.
TI - Response of gingiva equivalents to commensal and pathogenic oral microbiomes
VL - 27
ID - 13695
ER -
TY - JOUR
AB - In vitro models that closely mimic human host-microbiome interactions can be
a powerful screening tool for antimicrobials and will hold great potential for drug
validation and discovery. The aim of this study was to develop an organotypic oral
mucosa model that could be exposed to in vitro cultured commensal and pathogenic
biofilms in a standardized and scalable manner. The oral mucosa model consisted of
a tissue-engineered human gingiva equivalent containing a multilayered
differentiated gingiva epithelium (keratinocytes) grown on a collagen hydrogel,
containing gingiva fibroblasts, which represented the lamina propria. Keratinocyte
and fibroblast telomerase reverse transcriptase-immortalized cell lines were used
to overcome the limitations of isolating cells from small biopsies when scalable
culture experiments were required. The oral biofilms were grown under defined
conditions from human saliva to represent 3 distinct phenotypes: commensal,
gingivitis, and cariogenic. The in vitro grown biofilms contained physiologic
numbers of bacterial species, averaging >70 operational taxonomic units, including
20 differentiating operational taxonomic units. When the biofilms were applied
topically to the gingiva equivalents for 24 h, the gingiva epithelium increased its
expression of elafin, a protease inhibitor and antimicrobial protein. This
increased elafin expression was observed as a response to all 3 biofilm types,
commensal as well as pathogenic (gingivitis and cariogenic). Biofilm exposure also
increased secretion of the antimicrobial cytokine CCL20 and inflammatory cytokines
IL-6, CXCL8, and CCL2 from gingiva equivalents. This inflammatory response was far
greater after commensal biofilm exposure than after pathogenic biofilm exposure.
These results show that pathogenic oral biofilms have early immune evasion
properties as compared with commensal oral biofilms. The novel host-microbiome
model provides an ideal tool for future investigations of gingiva responses to
commensal and pathogenic biofilms and for testing novel therapeutics.
AN - rayyan-563562611
AU - Janus, M. M.
AU - Roffel, S.
AU - Krom, B. P.
AU - Gibbs, S.
DO - 10.1177/0022034517729998
IS - 2
PY - 2018
SN - ["0022-0345", "1544-0591"]
SP - 201-208
ST - Saliva-Derived Commensal and Pathogenic Biofilms in a Human Gingiva Model
T2 - JOURNAL OF DENTAL RESEARCH
TI - Saliva-Derived Commensal and Pathogenic Biofilms in a Human Gingiva Model
VL - 97
Y2 - 2
ID - 15985
ER -
TY - JOUR
AB - Periodontitis is a progressive destruction of both soft and hard tooth-
supporting tissues. In the last years, probiotics have been proposed as a support
to the gold standard treatment scaling and root planing (SRP), but no extensive
literature is present as regards the effect of the more recent postbiotics. Thirty
patients subjected to SRP were randomly assigned to two domiciliary hygiene
treatments based on the following oral gels: the postbiotics-based Biorepair
Parodontgel Intensive (Group 1) and the chlorhexidine-based Curasept Periodontal
Gel (Group 2). At baseline (T0) and after 3 and 6 months (T1–T2), the following
periodontal clinical parameters were recorded: Probing Pocket Depth (PPD),
recession, dental mobility, Bleeding on Probing (BoP), and Plaque Control Record
(PCR). A significant intragroup reduction was assessed in both groups for PPD, BoP,
and PCR; conversely, recession significantly increased in both groups, whereas
dental mobility did not vary. As regards intergroup comparisons, no statistically
significant differences were assessed. Both gels, respectively, containing
antioxidant natural ingredients and chlorhexidine, are effective for the
domiciliary treatment of periodontitis. Further studies are required to evaluate
the singular chemical compounds of the gels expected to exert the beneficial action
assessed in this preliminary study.
AN - rayyan-563559908
AU - Butera, A.
AU - Gallo, S.
AU - Pascadopoli, M.
AU - Taccardi, D.
AU - Scribante, A.
IS - 1
KW - NCT04781478
Aloe barbadensis extract
lactoferrin
probiotic agent
adult
Aloe vera
article
clinical article
clinical trial
controlled study
destruction
female
follow up
gingival index
gold standard
human
hygiene
male
mouth hygiene
nonhuman
periodontics
perioperative period
plant juice
plaque index
powder
root planing
tooth brushing
LA - English
PY - 2022
SN - 2079-6382
ST - Home Oral Care of Periodontal Patients Using Antimicrobial Gel with
Postbiotics, Lactoferrin, and Aloe Barbadensis Leaf Juice Powder vs. Conventional
Chlorhexidine Gel: A Split-Mouth Randomized Clinical Trial
T2 - Antibiotics
TI - Home Oral Care of Periodontal Patients Using Antimicrobial Gel with
Postbiotics, Lactoferrin, and Aloe Barbadensis Leaf Juice Powder vs. Conventional
Chlorhexidine Gel: A Split-Mouth Randomized Clinical Trial
VL - 11
ID - 13282
ER -
TY - JOUR
AB - Peri-implant mucositis consists of a reversible inflammation of peri-implant
tissues characterized by bleeding on gentle probing in the absence of bone loss.
Ozone therapy is being extensively studied for its efficacy in treating different
dental conditions. To date, few studies have evaluated ozone as an adjunct to the
oral hygiene measures of peri-implant mucositis patients. The aim of the present
study is to assess the efficacy of an ozonized gel (Trial group) compared to
chlorhexidine (Control group) after a domiciliary protocol of oral hygiene in a 6-
month study. According to a split-mouth study design, patients were divided into
Group 1 for the application of chlorhexidine gel in peri-implant mucositis sites of
quadrants Q1 and Q3, whereas in quadrants Q2 and Q4, the ozonized gel was in-office
administered. For Group 2, the quadrants were inverted. At baseline (T0), and after
1 (T1), 2 (T2), and 3 (T3) months, Probing Depth (PD), Plaque Index (PI), SI
Suppuration Index (SI), Bleeding Score (BS) and Marginal Mucosa Condition (MMC)
were measured. A statistically significant decrease was found for all the variables
assessed in each group (p < 0.05), whereas significant intergroup differences were
found only for PI, BoP, and BS. Accordingly, both agents tested in this study
showed an efficacy in treating peri-implant mucositis. The ozonized gel deserves
particular attention, considering the better outcome than chlorhexidine on specific
clinical periodontal parameters, as well as its lesser shortcomings.
AN - rayyan-563559751
AU - Butera, A.
AU - Gallo, S.
AU - Pérez-Albacete Martínez, C.
AU - Maté Sánchez de Val, J. E.
AU - Parisi, L.
AU - Gariboldi, A.
AU - Scribante, A.
DO - 10.3390/jcm12041464
IS - 4
KW - NCT05256914
Gracey
Implant Curette TIS2CN
Multipiezo
needle
periodontal curette
piezoelectric transducer
syringe
UNC probe 15
chlorhexidine
curasept
hydrogel
ozoal gel
ozone
ozoral pro
adult
aged
article
bleeding on probing
clinical article
controlled study
female
home care
human
male
marginal mucosa condition
mouth hygiene
mucosa
outcome assessment
ozonation
ozone therapy
peri-implant mucositis
periodontal pocket
plaque index
root planing
suppuration
LA - English
PY - 2023
SN - 2077-0383
ST - Ozonized Hydrogels vs. 1% Chlorhexidine Gel for the Clinical and Domiciliary
Management of Peri-Implant Mucositis: A Randomized Clinical Trial
T2 - J. Clin. Med.
TI - Ozonized Hydrogels vs. 1% Chlorhexidine Gel for the Clinical and Domiciliary
Management of Peri-Implant Mucositis: A Randomized Clinical Trial
VL - 12
ID - 13125
ER -
TY - JOUR
AN - rayyan-563561674
AU - Butera, A.
AU - Scribante, A.
AU - Maiorani, C.
AU - Chiesa, A.
AU - Lanteri, V.
AU - Esposito, F.
AU - Segù, M.
AU - Baena, R. R. Y.
IS - 2
PY - 2021
SP - 115-131
ST - Split mouth randomized controlled trial: Standard therapy vs ultrasonic
therapy with ozone gas application
T2 - International Journal of Clinical Dentistry
TI - Split mouth randomized controlled trial: Standard therapy vs ultrasonic
therapy with ozone gas application
85107619325&partnerID=40&md5=916dca4aa3dd5c49443aeabc51775ae2
VL - 14
ID - 15048
ER -
TY - JOUR
AB - Background and Aim: According to the literature, chlorhexidine is still
considered the gold standard product for the reactive phase of nonsurgical
periodontal therapy. Despite its effectiveness, evidence also shows several side
effects: aesthetic (dental discoloration), functional (hypogeusia and mucosal
changes), and allergic hypersensitivity. The main aim of the current study is to
compare the clinical efficacy of an experimental bioactive gel made with proactive
products (lactoferrin, zinc, hyaluronic acid, biomimetic hydroxyapatite and post-
biotics), with 1% chlorhexidine gel, used as adjuvants in the non-surgical
periodontal treatment, in a split-mouth study. Methods: 30 periodontal patients
(severity stage I and II - degree A and B) received non-surgical periodontal
treatment at the baseline and the application of two split-mouth gels. Biometric
indices (PPD, Recessions, BOP, PCR plaque index and Miller Mobility) were detected
at the baseline (t0) and at the follow-up t1 (1 month from t0), follow-up t2 (3
months from t0) and follow-up t3 (6 months from t0). Each subject was asked to
apply both gels at home for the 14 days following each professional session, using
blunt needle syringes or interdental brushes. Results: Mobility and recessions did
not result significantly improved. Indeed, the first parameter did not change,
while the second parameter has increased, from t0 to t3 in each of the tested
groups. PPD, BOP and PCR improved significantly in both groups from t0 to t3 (p <
0.05). According to the investigated variables there were no statistically
significant differences between the two groups. Conclusions: From the current
analysis, the clinical efficacy of the two gels resulted comparable. In particular,
the experimental gel we tested results effective not only for a proactive approach,
but it can also be applied to boost non-surgical periodontal treatment.
AN - rayyan-563559845
AU - Butera, A.
AU - Taccardi, D.
AU - Gallo, S.
AU - Scribante, A.
DO - 10.1111/jcpe.13636
KW - adjuvant
endogenous compound
hyaluronic acid
hydroxyapatite
lactoferrin
zinc
adult
clinical article
conference abstract
controlled study
drug therapy
female
follow up
human
male
mouth
periodontium
syringe needle
LA - English
PY - 2022
SN - 1600-051X
SP - 170
ST - Comparison of two adjuvant bioactive gels in non-surgical periodontal
treatment: A randomized split-mouth clinical trial
TI - Comparison of two adjuvant bioactive gels in non-surgical periodontal
treatment: A randomized split-mouth clinical trial
VL - 49
ID - 13219
ER -
TY - JOUR
AB - Porphyromonas gingivalis (P. gingivalis) is a periodontal pathogen that may
accumulate with other organisms in subgingival plaque biofilms and is associated
with periodontal disease. P. gingivalis fimbriae (FimA) is a filamentous structure
on the surface of bacteria that is closely associated with bacterial adhesion to
and colonization of host tissues, and serves an essential role in biofilm
formation. The present study aimed to construct P. gingivalis FimA prokaryotic
expression plasmids, purify a FimA fusion protein and explore the effect of a
recombinant FimA protein on the inflammatory response in human peripheral blood
mononuclear cells (PBMCs). P. gingivalis FimA prokaryotic expression plasmids were
constructed by gene cloning and recombination technology. SDS-PAGE was used to
evaluate the purified recombinant FimA protein. The cell proliferation rate and
inflammatory cytokine expression of PBMCs treated with the FimA fusion protein with
or without transfection with toll-like receptor 4 (TLR4) small interfering (si)RNA
were detected by CCK-8 assays and ELISAs, respectively. The expression levels of
TLR4, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and
myeloid differentiation primary response 88 (MyD88) in PBMCs were detected by
western blot analysis and reverse transcription quantitative polymerase chain
reaction. A FimA fusion protein with high purity was obtained. FimA fusion protein
treatment significantly increased PBMC proliferation and promoted the release of
tumor necrosis factor-α (TNF-α), interleukin (IL)-6, matrix metalloproteinase
(MMP)-8 and MMP-9 in PBMCs. TLR4 interference reversed the effects of the FimA
fusion protein on PBMC proliferation and inflammatory cytokine release. The
expression levels of TLR4, NF-κB and MyD88 in PBMCs were significantly increased
following treatment with the FimA fusion protein, while the expression levels of
these genes at the mRNA and protein levels decreased significantly in PBMCs
following FimA fusion protein treatment and TLR4 interference. The FimA fusion
protein increased PBMC proliferation and promoted the release of the inflammatory
cytokines TNF-α, IL-6, MMP-8 and MMP-9 via the TLR4/NF-κB signaling pathway. FimA
may serve as a promising therapeutic strategy for periodontal disease.
AN - rayyan-563560197
AU - Cai, J.
AU - Chen, J.
AU - Guo, H.
AU - Pan, Y.
AU - Zhang, Y.
AU - Zhao, W.
AU - Li, X.
AU - Li, Y.
DO - 10.3892/ijmm.2019.4069
IS - 3
KW - fimbria protein
fusion protein
gelatinase B
interleukin 6
messenger RNA
myeloid differentiation factor 88
recombinant protein
adult
article
cell counting
cell proliferation
controlled study
cytokine release
gene construct
human
human cell
molecular cloning
nonhuman
periodontitis
plasmid
priority journal
prokaryote
protein expression
protein function
protein protein interaction
recombinant DNA technology
signal transduction
Western blotting
LA - English
PY - 2019
SN - ["1791-244X", "1107-3756"]
SP - 1430-1440
ST - Recombinant fimbriae protein of Porphyromonas gingivalis induces an
inflammatory response via the TLR4/NF-κB signaling pathway in human peripheral
blood mononuclear cells
T2 - Int. J. Mol. Med.
TI - Recombinant fimbriae protein of Porphyromonas gingivalis induces an
inflammatory response via the TLR4/NF-κB signaling pathway in human peripheral
blood mononuclear cells
VL - 43
ID - 13571
ER -
TY - JOUR
AB - Objectives: The aim of the present case series was to evaluate the clinical
and microbiological effects of a single session of mechanical and manual scaling
and root planing (SRP) combined with the use of two different chlorhexidine
formulations in the treatment for generalized chronic periodontitis. Methods: Ten
patients affected by chronic periodontal disease with periodontal probing depth
(PPD) ≥ 5 mm were treated with SRP plus local chlorhexidine. In each patient,
similar teeth, treated with SRP with the adjunctive use of chlorhexidine
digluconate and dihydrochloride or chlorhexidine gluconate, respectively, were
selected and assigned to a test and a control group. In both groups, PPD, bleeding
on probing (BOP) parameters, total bacterial counts (TBC) and quality of
periodontal bacteria at time 0 and 6 weeks after treatment were measured. Results:
PPD significantly decreased over time both in the test and in the control group;
however, no significant differences between the two groups were observed. BOP and
TBC were significantly lower in the test than in the control group 6 weeks after
treatment. In the post-treatment revaluation, a significant decrease both in the
treatment and in the control group, for each of the single periodontal pathogens,
was observed. Conclusion: In this study - a preliminary case series with small
sample size and short follow-up - the adjunctive use of chlorhexidine (CHX) to SRP
resulted in clinical and microbiological benefits in the treatment for generalized
chronic periodontitis. A CHX gel formulation consisting of CHX digluconate and CHX
dihydrochloride seems to lead some additional benefits over SRP plus CHX gluconate
in the short term. Additional investigations are needed to evaluate the
effectiveness of this antiseptic therapy. © 2012 John Wiley & Sons A/S.
AN - rayyan-563560474
AU - Calderini, A.
AU - Pantaleo, G.
AU - Rossi, A.
AU - Gazzolo, D.
AU - Polizzi, E.
DO - 10.1111/idh.12009
IS - 3
KW - chlorhexidine
drug derivative
adjuvant chemotherapy
adult
article
Bacteroides
chemistry
controlled study
drug effect
devices
human
micro-organism
microbiology
middle aged
nonparametric test
periodontics
periodontitis
tooth plaque
Treponema denticola
LA - English
PY - 2013
SN - ["1601-5029", "1601-5037"]
SP - 180-185
ST - Adjunctive effect of chlorhexidine antiseptics in mechanical periodontal
treatment: First results of a preliminary case series
T2 - Int. J. Dent. Hyg.
TI - Adjunctive effect of chlorhexidine antiseptics in mechanical periodontal
treatment: First results of a preliminary case series
VL - 11
ID - 13848
ER -
TY - JOUR
AB - The purpose of this study was to record the time-course diffusion of hydrogen
peroxide through human dentin from a peroxide carbamide gel designed for the
walking bleach technique in order to determine its optimal renewal time. It was
considered that the optimal renewal rate corresponded to the time necessary to
achieve 80% of the maximal diffusion because a much longer time does not involve
further significant diffusion. Thirty-six freshly extracted human premolars were
used for this study. Eighteen were extracted for orthodontic reasons on patients
under 20 years old (young-teeth group). Eighteen were extracted for periodontal
reasons on patients between 40 and 60 years old (old-teeth group). The teeth were
endodontically treated, and a flat defect was created at the enamel-cementum
junction. The teeth were suspended in vials containing water, and the access
cavities were filled with 20 μL of 20% hydrogen peroxide gel. The amount of
diffusing hydrogen peroxide was assessed at 1 hour, 24 hours, 48 hours, and 120
hours. The diffusive flux and the maximal diffusion were calculated as well as the
optimal renewal time. Hydrogen peroxide diffusion through young teeth lasted 352
hours but lasted 291 hours through old teeth. Diffusive flux and maximal diffusion
were higher through young teeth than through old teeth. The optimal renewal time
for young teeth was 33 hours and for old teeth was 18 hours. © 2007 American
Association of Endodontists.
AN - rayyan-563560749
AU - Camps, J.
AU - de Franceschi, H.
AU - Idir, F.
AU - Roland, C.
AU - About, I.
DO - 10.1016/j.joen.2006.12.006
IS - 4
KW - drug derivative
hydrogen peroxide
oxidizing agent
peroxide
urea
carbamide peroxide
adolescent
adult
age
article
child
dental procedure
dentin
diffusion
drug combination
endodontics
human
materials testing
metabolism
methodology
middle aged
time
tooth cervix
tooth pulp
tooth pulp disease
LA - English
PY - 2007
SN - 0099-2399
SP - 455-459
ST - Time-Course Diffusion of Hydrogen Peroxide Through Human Dentin: Clinical
Significance for Young Tooth Internal Bleaching
T2 - J. Endod.
TI - Time-Course Diffusion of Hydrogen Peroxide Through Human Dentin: Clinical
Significance for Young Tooth Internal Bleaching
VL - 33
ID - 14123
ER -
TY - JOUR
AB - Objective: The effect of the hyaluronic acid (HA) on laser- A ssisted
frenectomy wound healing has not been tested. This controlled, randomized,
examiner-blinded clinical study aimed to compare the outcomes of laser-assisted
frenectomy with and without an HA-containing gel application. Method and materials:
The study included 40 patients aged 18 to 40 years, with high labial frenulum
attachment requiring frenectomy. Following laser-assisted frenectomy, HA-gel was
applied topically to the wound surface at the day of frenectomy and on days 3,7,
and 14 postoperatively in the test group, and no application was made to the
control group. The photographs were taken at the day of frenectomy and on days 3,
7, and 14 postoperatively. A total of 160 images were uploaded to the software.The
changes in the area measurements from baseline values were calculated. A visual
analog scale (VAS) was used to evaluate patients'satis-faction. Results: The
primary outcome variable was the change in the wound area from baseline to
postoperative 3, 7 and 14 days. The area measurements and VAS scores were
significantly lower in the test group than in the control group at all
postoperative assessment time points (P < .001). According to the percentage
changes calculated at postoperative assessment points, the highest percentage was
found on day 14 in the test group, and the lowest value was identified on day 3 in
the control group. Conclusion: HA was observed to be a viable option for decreasing
the surface area of the wound and to act as a wound dressing following frenectomy.
HA application also in-creased patient satisfaction postoperatively.
AN - rayyan-563560136
AU - Cankaya, Z. T.
AU - Gurbuz, S.
AU - Bakirarar, B.
AU - Onsal, B.
AU - Kurtif, B.
DO - 10.3290/j.qi.a43667
IS - 3
KW - diode laser
periodontal probe
SiroLaser Advanced Plus
hyaluronic acid
adult
article
clinical article
controlled study
drug efficacy
drug safety
female
gingival index
human
laser assisted frenectomy
laser surgery
male
mouth hygiene
mouth plaque
outcome variable
patient satisfaction
periodontal procedure
photography
postoperative care
visual analog scale
wound healing
LA - English
PY - 2020
SN - 0033-6572
SP - 188-201
ST - Evaluation of the effect of the application of hyaluronic acid following
laser-assisted frenectomy: An examiner-blind, randomized, controlled clinical study
TI - Evaluation of the effect of the application of hyaluronic acid following
laser-assisted frenectomy: An examiner-blind, randomized, controlled clinical study
VL - 51
ID - 13510
ER -
TY - JOUR
AB - Background: Cytokines can induce a chronic inflammatory response in the
periodontium, leading to periodontitis. Quercetin, a naturally occuring flavonoid,
has been shown to inhibit periodontitis, but how it works is poorly understood. In
this study, we assessed the impact of quercetin on lipopolysaccharide (LPS)-induced
inflammatory damage in oral mucosal keratinocytes (hOMK107) and explored its
underlying mechanism. Methods: The viability and apoptosis of hOMK107 cells were
measured after exposure to LPS, followed or not by quercetin. The production of IL-
1β, IL-6, IL-8, TNF-ɑ, iNOS, and COX-2 was quantified by enzyme-linked
immunosorbent assay (ELISA), while levels of Akt, AMPK, and mTOR and their
phosphorylation were detected semi-quantitatively by western blotting. Results:
Quercetin significantly improved cell viability and apoptosis by reversing LPS-
induced upregulation of Bax and downregulation of Bcl-2 in hOMK107 cells. Quercetin
decreased the production of IL-1β, IL-6, IL-8, TNF-ɑ, iNOS, and COX-2, as well as
signal transduction via the Akt/AMPK/mTOR pathway. Inhibitors of Akt, AMPK, and
mTOR strengthened the anti-apoptotic effects of quercetin, while agonists of Akt,
AMPK, or mTOR or Akt overexpression weakened the anti-apoptotic effects.
Conclusion: These results indicate that quercetin may have a potential protective
effect against the chronic inflammation-related periodontitis via suppressing
Akt/AMPK/mTOR pathway.
AN - rayyan-563560042
AU - Cao, J. H.
AU - Xue, R.
AU - He, B.
DO - 10.1080/08923973.2021.1948565
IS - 5
KW - ELISA kit
cyclooxygenase 2
hydroxymethylglutaryl coenzyme A reductase kinase
inducible nitric oxide synthase
interleukin 1beta
interleukin 6
interleukin 8
lipopolysaccharide
mammalian target of rapamycin
protein Bax
protein bcl 2
protein kinase B
quercetin
apoptosis
article
cell viability
controlled study
down regulation
gene overexpression
human
human cell
human tissue
keratinocyte
mouth mucosa
periodontitis
signal transduction
LA - English
PY - 2021
SN - ["1532-2513", "0892-3973"]
SP - 519-526
ST - Quercetin protects oral mucosal keratinocytes against lipopolysaccharide-
induced inflammatory toxicity by suppressing the AKT/AMPK/mTOR pathway
T2 - Immunopharmacol. Immunotoxicol.
TI - Quercetin protects oral mucosal keratinocytes against lipopolysaccharide-
induced inflammatory toxicity by suppressing the AKT/AMPK/mTOR pathway
VL - 43
ID - 13416
ER -
TY - JOUR
AB - Among the crowd of bacteria provoking disease of the oral cavity during the
weakened of immune system, Streptococcus mutans and Porphyromonas gingivalis are
the main microorganisms implicated in caries formation and periodontitis,
respectively. The life cycle of the pathogens, such as protozoa, fungi and
bacteria, is influenced by a superfamily of enzymes, called carbonic anhydrases
(CAs, EC 4.2.1.1). These metalloenzymes, being crucial for the survival of the
pathogen, have been considered as novel anti-infective targets. In fact,
bicarbonate and protons, produced by the CA catalyzed carbon dioxide as substrate,
are two fundamental ions implicated in the pH regulation, biosynthetic reactions,
and adaptation of the pathogen to the host or in the possibility of the pathogen to
avoid the host immune system. Bacteria genome encodes for the α-, β- and γ-CAs.
Recently, our groups using the recombinant DNA technology prepared and
characterized the CAs belonging to the β- and γ-classes encoded by the genome of
the two oral cavity pathogens S. mutans and P. gingivalis. An extensive inhibition
study was carried out using typical anion/sulfonamide inhibitors of these classes
of CAs. We discovered numerous inhibitors, which had in vitro an effective
inhibitory activity against the bacterial CAs considered, here, as alternative
anti-infective targets.
AN - rayyan-563560335
AU - Capasso, C.
AU - Supuran, C. T.
DO - 10.2174/1568026616666160413135522
IS - 21
KW - carbonate dehydratase
carbonate dehydratase inhibitor
sulfonamide
article
dental caries
enzyme inhibition
human
mouth flora
nonhuman
periodontal disease
protein expression
X ray crystallography
LA - English
PY - 2016
SN - ["1873-4294", "1568-0266"]
SP - 2359-2368
ST - An overview of the carbonic anhydrases from two pathogens of the oral cavity:
Streptococcus mutans and Porphyromonas gingivalis
T2 - Curr. Top. Med. Chem.
TI - An overview of the carbonic anhydrases from two pathogens of the oral cavity:
Streptococcus mutans and Porphyromonas gingivalis
VL - 16
ID - 13709
ER -
TY - JOUR
AB - Background: The present study evaluated the healing of enamel matrix
derivative (EMD) proteins in the treatment of periodontal lesions with deep
intrabony defects. Methods: Ten deep intrabony defects in 7 periodontal patients
were treated and followed for 1 year. The sites had a probing depth (PD) ≥8 mm;
clinical attachment level (CAL) ≥9 mm, and intrabony component depth ≥5 mm. All
subjects received therapy prior to surgery and had a plaque score (PI) ≤10%. Full
thickness flaps were elevated buccally and lingually, granulation tissue was
removed from the defects, and the root surfaces were planed. A 24% EDTA gel was
applied followed by the enamel matrix protein preparation. The flaps were closed
with interrupted sutures. The patients rinsed with a chlorhexidine solution twice a
day for 6 weeks. They were recalled every 2 weeks for 6 months for professional
tooth cleaning and then every 4 weeks for an additional 6 months. The experimental
sites were re-examined 6 and 12 months after regenerative surgery. Results: At the
1-year examination, the mean CAL gain was 6.5 mm, the mean PD was 3.2 mm, and mean
radiographic bone fill was 4.7 mm. Conclusions: The application of enamel matrix
proteins in combination with open flap curettage and root planing resulted in a
gain of CAL and bone fill in deep intrabony defects.
AN - rayyan-563560902
AU - Cardaropoli, G.
AU - Leonhardt, Å S.
DO - 10.1902/jop.2002.73.5.501
IS - 5
KW - chlorhexidine
edetic acid
enamel protein
adult
article
bone defect
clinical article
clinical trial
controlled study
dental surgery
enamel
female
follow up
granulation tissue
healing
human
male
parameters
periodontal disease
surgical technique
suture
tooth plaque
tooth root
treatment outcome
wound closure
LA - English
PY - 2002
SN - 0022-3492
SP - 501-504
ST - Enamel matrix proteins in the treatment of deep intrabony defects
TI - Enamel matrix proteins in the treatment of deep intrabony defects
VL - 73
ID - 14276
ER -
TY - JOUR
AB - Introduction: Different periodontal surgeries are used to treat a variety of
periodontal conditions in favour of a healthy and aesthetic periodontium [1].
However, the fear of surgical treatment is common, most often depriving patients of
undergoing complete dental treatments. Patients' questions and concerns are often
pain-related [2]. Adequate understanding of the intensity and variables that affect
pain is essential because it can produce emotional responses that may influence
treatment adherence [3]. The objectives of this study are evaluation of pain after
periodontal surgery and its relationship with variables related to the patient,
surgery and postoperative care. Materials and methods: This study was approved by
the Egas Moniz Ethics Committee and by the Direction of the Egas Moniz University
Clinic (CUEM). All patients referred in the sample signed an informed consent form.
Questionnaires were applied to 63 patients submitted to periodontal surgeries at
the Post-graduation Course of Periodontology at the CUEM. Data was collected
through the completion of two questionnaires. The first questionnaire was composed
of two parts and was applied in the presence of the patient. The part A was done on
the day of surgery for the purpose of collecting data from the patient's clinical
history and related with the surgery; and the part B on the day of suture removal
about post-operative care. The second was delivered on the day of surgery with the
Visual Analogue Scale. The patient was asked to fill it on the day of surgery, on
the next two days after surgery and also on the day of suture removal, returning it
on that day. Results: It was found that the highest pain levels were experienced by
the patients on the day of surgery, with a median value of 6.9. The degree of
postoperative pain is not related with gender, type of periodontal disease, type of
periodontal surgery, technique performed, teeth involved, duration of surgery,
antibiotic intake, use of chlorhexidine gel and mouthwash, absence of mechanical
plaque control and absence of physical exercise. On the other hand, the degree of
postoperative pain is dependent on factors such as age (with older patients
experiencing less pain), smoking habits and smoking cessation (non-smoking patients
or those who stopped the habit in the postoperative period showed less
postoperative pain). The use of nonsteroidal anti-inflammatory drugs and its
duration influence the postoperative pain. Discussion and conclusions: Periodontal
treatment often includes several surgical procedures, so a bad postoperative period
may prevent the patient from continuing treatment, which may in some cases
jeopardise the maintenance of teeth. Smoking habits have been shown to be the most
prominent variable in postoperative pain. It is therefore extremely important to
encourage patients to stop smoking or when it is not possible to interrupt during
the postoperative period.
AN - rayyan-563560061
AU - Cardoso, J. M.
AU - Ribeiro, M.
AU - Alves, R.
DO - 10.1080/07853890.2021.1897343
KW - antibiotic agent
mouthwash
nonsteroid antiinflammatory agent
adult
age
ambulatory surgery
clinical evaluation
conference abstract
controlled study
emotion
exercise
female
gender
human
human tissue
informed consent
male
operation duration
periodontal disease
periodontics
postoperative care
postoperative pain
prevention
professional standard
questionnaire
smoking cessation
smoking habit
surgical technique
suture removal
visual analog scale
LA - English
PY - 2021
SN - 1365-2060
SP - S42-S43
ST - Evaluation of postoperative pain in patients submitted to periodontal
surgeries
T2 - Ann. Med.
TI - Evaluation of postoperative pain in patients submitted to periodontal
surgeries
VL - 53
ID - 13435
ER -
TY - JOUR
AN - rayyan-563561181
AU - Carl, W.
IS - 4
KW - aciclovir
antibiotic agent
bicarbonate
bleomycin
busulfan
carmustine
chlormethine
clotrimazole
cyclophosphamide
cytarabine
cytostatic agent
daunorubicin
dextromethorphan
disinfectant agent
doxorubicin
flo gel
fluoride
fluorouracil
hydrogen peroxide
kaolin pectin
ketoconazole
lidocaine
melphalan
mercaptopurine
methotrexate
morphine
racemethorphan
tannin fluoride
thrombin
unclassified drug
blood and hemopoietic system
bone marrow depression
bone marrow transplantation
cancer chemotherapy
case report
dental procedure
drug toxicity
gastrointestinal toxicity
gingivitis
human
intoxication
mouth
mouth ulcer
mucosa inflammation
review
therapy
tooth
benylin
xylocaine
LA - English
PY - 1986
SN - 8756-0437
SP - 187-199
ST - Oral manifestations of systemic chemotherapy and their management
T2 - SEMIN. SURG. ONCOL.
TI - Oral manifestations of systemic chemotherapy and their management
VL - 2
ID - 14555
ER -
TY - JOUR
AB - Background and Objectives: Considering the high possibility of dentist
consult a patient with oral complications of chemotherapy and/or radiotherapy for
oral cancer because of the advances in this area, this study aims to systematically
review the literature to identify and suggest effective and safe protocols for the
managements of oral complications in oncology patients. Material and Methods: The
systematic review was designed by PICO and PRISMA including eligibility and
exclusion criteria; the source of information and search strategy in PubMed
according MeSH: “Mouth Neoplasms and Radiotherapy” and “Mouth Neoplasms and Drug
Therapy” the period from 2010 to 2015; selection and data collection of study was
carried form blind and independently by two researchers; risk of bias and
methodological quality: ensured by the PEDro scale; synthesis of data: of oral
complications were evaluated by adapted version of associative direction
classification proposed by Costigan and collaborators; and data analysis was
performed by the meta-analysis of BioEstat program (5.0) in the included studies.
Results: 2,700 articles found, 2,371 were selected after removal of duplicate and
elected 40 full-text articles. Of these, only 06 articles were included in the
systematic review with exclusion of others, per obtain punctuation ≥ 7 with high
methodological quality for synthesis of the managements of oral complications.
Since 05 articles were associated with low risk of bias composing the protocols
suggestive for managements and the meta-analysis in odds ratio (0.916) to cure and
relative risk (1.049) for the development of oral mucositis and pain. Conclusions:
The protocols suggestive for managements of oral mucositis and pain with MuGard -
mucoadhesive hydrogel; PerioAid Tratamiento® antiseptic mouthrinse with
chlorhexidine and cetylpyridinium chloride; Episil® plus benzydamine - bioadhesive
oromucosal gel; 0,03% of Triclosan mouthwash Colgate Plax; and Diode Laser Therapy
of low-level are safe for oncology patients applied according to adopted clinical
parameters.
AN - rayyan-563560314
AU - Carneiro-Neto, J. N.
AU - de-Menezes, J. D. S.
AU - Moura, L. B.
AU - Massucato, E. M. S.
AU - de-Andrade, C. R.
DO - 10.4317/medoral.21314
IS - 1
KW - biologic glue
mouthwash
triclosan
bibliographic database
cancer chemotherapy
cancer radiotherapy
chemoradiotherapy
data analysis
dysphagia
human
hydrogel
low level laser therapy
meta analysis
mouth cancer
mouth pain
mycosis
oral mucositis
periodontal disease
quality control
review
risk factor
systematic review
xerostomia
colgate plax
episil
mugard
perioaid tratamiento
InGaAlP
LA - English
PY - 2017
SN - ["1698-6946", "1698-4447"]
SP - e15-e23
ST - Protocols for management of oral complications of chemotherapy and/or
radiotherapy for oral cancer: Systematic review and meta-analysis current
T2 - Med. Oral Patol. Oral Cir. Bucal
TI - Protocols for management of oral complications of chemotherapy and/or
radiotherapy for oral cancer: Systematic review and meta-analysis current
VL - 22
ID - 13688
ER -
TY - JOUR
AB - Background: Tooth staining is a common feature of chlorhexidine treatment for
periodontal disease and there is a large variation between patients as to the
degree of their tooth staining. Although the mechanism of tooth staining is
uncertain, diet, smoking and oral hygiene appear probable factors. Objectives: This
study investigated the role of saliva in chlorhexidine-induced tooth staining and
used tea as the staining agent in an in vitro model with hydroxyapatite mimicking
teeth. Methods: Saliva has been used to create an acquired pellicle and in solution
to mimic its effects in vivo. Using different combinations of tea, chlorhexidine
and parotid saliva, substances binding to hydroxyapatite were analysed by sodium
dodecyl sulfate-polyacrylamide gel electrophoresis. Using this system, tea,
chlorhexidine and salivary proteins were clearly identifiable following staining by
Coomassie Brilliant Blue. Results: The results indicated that tea interacted with
many salivary proteins, in particular proline-rich proteins and histatins.
Chlorhexidine did not appear to complex with or precipitate salivary proteins nor
prevent the formation of an acquired pellicle on the hydroxyapatite. In isolation,
tea and chlorhexidine bound in small amounts to hydroxyapatite, but when added in
combination, binding of both to hydroxyapatite was greatly increased. The acquired
pellicle reduced chlorhexidine and tea binding, but conversely increased the
binding of either tea or chlorhexidine alone to hydroxyapatite. Conclusion: In
conclusion, salivary proteins play an important role in the staining process and
the combination of tea and chlorhexidine appears to be a very potent staining
factor. © Blackwell Munksgaard 2005.
AN - rayyan-563560840
AU - Carpenter, G. H.
AU - Pramanik, R.
AU - Proctor, G. B.
DO - 10.1111/j.1600-0765.2005.00791.x
IS - 3
KW - brilliant blue
chlorhexidine
histatin
hydroxyapatite
protein
article
in vitro study
saliva
simulation
staining
tea
tooth color
tooth staining
LA - English
PY - 2005
SN - 0022-3484
SP - 225-230
ST - An in vitro model of chlorhexidine-induced tooth staining
TI - An in vitro model of chlorhexidine-induced tooth staining
VL - 40
ID - 14214
ER -
TY - JOUR
AB - The Authors studies effects of chlorexidine gel 1% on subgingival microbial
flora in a group of periodontal patients. Microbial findings appear to demonstrate
some activity of chlorexidine gel 1%.
AN - rayyan-563561172
AU - Caruso, F.
AU - Guida, L.
AU - Iuorio, G.
AU - Sanges, M. R.
AU - Gorga, F.
AU - Martini, G.
IS - 6
KW - chlorhexidine
adult
article
female
gel
human
male
microbiology
periodontal disease
tooth plaque
LA - Italian
PY - 1989
SN - 0004-0320
SP - 1145-1153
ST - Chlorhexidine gel for control of subgingival bacterial plaque: experimental
microbiological evaluation
T2 - Il gel di clorexidina nel controllo della placca batterica subgengivale:
valutazione sperimentale microbiologica.
TI - Chlorhexidine gel for control of subgingival bacterial plaque: experimental
VL - 30
ID - 14546
ER -
TY - JOUR
AB - This clinical study investigated the effects of endodontic treatment by using
different irrigants (limewater + NaOCl and polymyxin B + NaOCl) and intracanal
medication on endotoxins in teeth with primary endodontic infection and
radiographically visible apical periodontitis. Thirty-three teeth with necrotic
pulp and periapical lesions from different patients were selected for this study.
Samples were collected after the coronal opening (S1) and after instrumentation
(S2). Root canals were divided in 3 groups (n = 11) according to the irrigant
combination used: NaOCl + LW: 2.5% NaOCl + calcium hydroxide solution (0.14%,
limewater); NaOCl + PmB: 2.5% NaOCl + 10.000 UI/mL polymyxin B; 2.5% NaOCl
(control). The third sampling (S3) was performed after ethylenediaminetetraacetic
acid and the fourth (S4) after samples got 14 days with intracanal medication with
2% chlorhexidine gel + calcium hydroxide. Endotoxins (lipopolysaccharide) were
quantified by chromogenic Limulus amebocyte lysate (LAL). Endotoxins were detected
in all root canals after the coronal opening (S1). NaOCl + PmB group presented the
greatest endotoxin reduction after instrumentation (76.17%), similar to NaOCl + LW
group (67.64%, p<0.05) and different from NaOCl group (42.17%, p<0.05). After
intracanal medication period (S4), there was significant increase of endotoxins
neutralization. It was concluded that NaOCl + PmB promoted the greatest reduction
of endotoxin levels, followed by NaOCl + LW. Intracanal medications had no
significant complementary role in the reduction of endotoxins at the end of the
treatment.
AN - rayyan-563560337
AU - Carvalho, A. S.
AU - Oliveira, L. D.
AU - Cardoso, F. G.
AU - Oliveira, F. E.
AU - Valera, M. C.
AU - Carvalho, C. A.
DO - 10.1590/0103-6440201600934
IS - 5
KW - endotoxin
polymyxin B
adult
female
human
male
procedures
LA - English
PY - 2016
SN - 1806-4760
SP - 573-577
ST - Limewater and Polymyxin B Associated with NaOCl for Endotoxin Detoxification
in Root Canal with Necrotic Pulp
T2 - Braz Dent J
TI - Limewater and Polymyxin B Associated with NaOCl for Endotoxin Detoxification
in Root Canal with Necrotic Pulp
VL - 27
ID - 13711
ER -
TY - JOUR
AB - Local drug delivery of antimicrobics by sustained release delivery system can
be used to treat periodontal disease. Advantages of these systems may include
maintaining high levels of antibiotic in the gingival crevicular fluid for a
sustained period of time and ease of use with high patient acceptance. The
materials used are TiO2 and TiO24SiO2, mixed with sodium ampicillin, a broad-
spectrum antibiotic, have been synthesized by sol-gel method. The amorphous nature
of the gels was ascertained by X-ray diffraction analysis. Release kinetics in a
simulated body fluid (SBF) have been subsequently investigated. The amount of
sodium ampicillin released has been detected by UV-VIS spectroscopy and SEM. The
release kinetics seems to occur in more than one stage. HPLC analysis has also been
taken to ensure the integrity of ampicillin after the synthetic treatment. Finally,
SEM micrographs and EDS analysis showed the formation of a hydroxyapatite layer on
the surface of the samples soaked in SBF. Both the materials showed good release
and could be used as drug delivery bioactive systems. High antimicrobial effects of
samples against Escherichia coliand Streptococcus mutants were found. © Springer
Science + Business Media, LLC 2006.
AN - rayyan-563560774
AU - Catauro, M.
AU - Raucci, M. G.
AU - Convertito, C.
AU - Melisi, D.
AU - Rimoli, M. G.
DO - 10.1007/s10856-006-8468-7
IS - 5
KW - ampicillin
hydroxyapatite
silicon dioxide
titanium dioxide
article
bacterial growth
body fluid
controlled study
Escherichia coli
gel
incubation time
nonhuman
priority journal
simulation
synthesis
ultraviolet spectroscopy
LA - English
PY - 2006
SN - 0957-4530
SP - 413-420
ST - Characterization, bioactivity and ampicillin release kinetics of TiO 2 and
TiO24SiO2 synthesized by sol-gel processing
TI - Characterization, bioactivity and ampicillin release kinetics of TiO 2 and
VL - 17
ID - 14148
ER -
TY - JOUR
sustained period of time and ease Of use with high patient acceptance. The
materials used are TiO2 and TiO(2)4SiO(2), mixed with sodium ampicillin, a broad-
spectrum antibiotic, have been synthesized by sot-gel method. The amorphous nature
samples against Escherichia coli and Streptococcus mutants were found.
AN - rayyan-563562498
AU - Catauro, M.
AU - Raucci, M. G.
AU - Convertito, C.
AU - Melisi, D.
AU - Rimoli, M. G.
DO - 10.1007/s10856-006-8468-7
IS - 5
PY - 2006
SN - 0957-4530
SP - 413-420
ST - Characterization, bioactivity and ampicillin release kinetics of TiO2 and
TiO(2)4SiO(2) synthesized by sol-gel processing
T2 - JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
TI - Characterization, bioactivity and ampicillin release kinetics of TiO2 and
TiO(2)4SiO(2) synthesized by sol-gel processing
VL - 17
Y2 - 5
ID - 15872
ER -
TY - JOUR
sustained period of time and ease of use with high patient acceptance. The
materials used are TiO(2) and TiO(2)4SiO(2), mixed with sodium ampicillin, a broad-
spectrum antibiotic, have been synthesized by sol-gel method. The amorphous nature
samples against Escherichia coli and Streptococcus mutants were found.
AN - rayyan-563561400
AU - Catauro, M.
AU - Raucci, M. G.
AU - Convertito, C.
AU - Melisi, D.
AU - Rimoli, M. G.
DO - 10.1007/s10856-006-8468-7
IS - 5
J2 - J Mater Sci Mater Med
KW - Ampicillin/chemistry
Anti-Bacterial Agents/pharmacology
Dose-Response Relationship, Drug
Durapatite/chemistry
Escherichia coli/metabolism
Gingiva/metabolism
In Vitro Techniques
Kinetics
Materials Testing/methods
Microscopy, Electron, Scanning
Phase Transition
Silicon Dioxide/*chemistry
Streptococcus/metabolism
Surface Properties
Titanium/*chemistry
X-Ray Diffraction
LA - eng
N1 - Department of Materials and Productions Engineering, University of Naples
Federico II, Piazzale Tecchio, 80125, Naples, Italy.
PY - 2006
SN - 0957-4530 (Print)
SP - 413-20
ST - Characterization, bioactivity and ampicillin release kinetics of TiO2 and
T2 - Journal of materials science. Materials in medicine
TI - Characterization, bioactivity and ampicillin release kinetics of TiO2 and
VL - 17
Y2 - 5
ID - 14774
ER -
TY - JOUR
AN - rayyan-563561862
AU - Chadha, V. S.
AU - Bhat, K. M.
DO - 10.4103/0972-124X.99262
IS - 2
PY - 2012
SP - 200-206
ST - The evaluation of doxycycline controlled release gel versus doxycycline
controlled release implant in the management of periodontitis
TI - The evaluation of doxycycline controlled release gel versus doxycycline
controlled release implant in the management of periodontitis
84866707002&doi=10.4103%2f0972-
124X.99262&partnerID=40&md5=b16ec6b6a0a63cfbd77daab026ace89a
VL - 16
ID - 15236
ER -
TY - JOUR
AB - Salivary gland aplasia and hypoplasia are rarely described in the medical
literature. This article presents a case of aplasia and hypoplasia of the major
salivary glands in a patient with Down syndrome. A literature review, as well as an
overview of the diagnosis and management of this condition, is presented.
AN - rayyan-563560296
AU - Chadi, M. J.
AU - Saint Georges, G.
AU - Albert, F.
AU - Mainville, G.
AU - Nguyen, J. M.
AU - Kauzman, A.
DO - 10.1002/ccr3.975
IS - 6
KW - antifungal agent
fluoride
adult
aplasia
article
case report
dental surgery
Down syndrome
echography
edema
erythema
gel
human
hydration
hypoplasia
maxilla
mucosal dryness
occlusal splint
parotid gland
periodontal disease
priority journal
rehabilitation care
submandibular gland
thrush
tongue disease
xerostomia
young adult
LA - English
PY - 2017
SN - 2050-0904
SP - 939-944
ST - Major salivary gland aplasia and hypoplasia in Down syndrome: review of the
literature and report of a case
T2 - Clin. Case Rep.
TI - Major salivary gland aplasia and hypoplasia in Down syndrome: review of the
literature and report of a case
VL - 5
ID - 13670
ER -
TY - JOUR
AB - Scutellaria baicalensis root displays anti-inflammatory and antibacterial
properties due to the presence of flavonoids, particularly baicalin, baicalein, and
wogonin. Our work aimed at developing thermosensitive hydrogels containing a binary
mixture of S. baicalensis radix lyophilized extract and chitosan as a novel
approach for periodontal diseases treatment. Two types of chitosan were employed in
preliminary studies on binary mixtures with S. baicalensis radix lyophilized
extract standardized for baicalin, baicalein, and wogonin. Thermosensitive
hydrogels were prepared of poloxamer 407, alginate sodium, and cellulose
derivatives and evaluated in terms of rheological and mucoadhesive behavior. The
presence of chitosan altered the release profile of active compounds but did not
affect their in vitro permeation behavior in PAMPA assay. The synergistic effects
of S. baicalensis radix lyophilized extract and chitosan toward ferrous ion-
chelating activity, inhibition of hyaluronidase, and pathogen growth were observed.
The thermosensitive gelling system showed shear-thinning properties, gelation
temperature between 25 and 27 & DEG;C, and favorable mucoadhesiveness in contact
with porcine buccal mucosa, which was enhanced in the presence of binary mixture of
S. baicalensis radix extract and chitosan. The release tests showed that baicalin
and baicalein were liberated in a prolonged manner with a fast onset from hydrogel
formulations.
AN - rayyan-563562349
AU - Chanaj-Kaczmarek, J.
AU - Osmalek, T.
AU - Szymanska, E.
AU - Winnicka, K.
AU - Karpinski, T. M.
AU - Dyba, M.
AU - Bekalarska-Debek, M.
AU - Cielecka-Piontek, J.
DO - 10.3390/ijms222111319
IS - 21
PY - 2021
SN - 1422-0067
ST - Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture
of Scutellariae baicalensis radix Extract and Chitosan for Periodontal Diseases
Treatment
T2 - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
TI - Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture
of Scutellariae baicalensis radix Extract and Chitosan for Periodontal Diseases
Treatment
VL - 22
Y2 - 11
ID - 15723
ER -
TY - JOUR
AB - Scutellaria baicalensis root displays anti-inflammatory and antibacterial
properties due to the presence of flavonoids, particularly baicalin, baicalein, and
wogonin. Our work aimed at devel-oping thermosensitive hydrogels containing a
binary mixture of S. baicalensis radix lyophilized extract and chitosan as a novel
approach for periodontal diseases treatment. Two types of chitosan were employed in
preliminary studies on binary mixtures with S. baicalensis radix lyophilized
extract standardized for baicalin, baicalein, and wogonin. Thermosensitive
hydrogels were prepared of poloxamer 407, alginate sodium, and cellulose
derivatives and evaluated in terms of rheological and mucoadhesive behavior. The
presence of chitosan altered the release profile of active compounds but did not
affect their in vitro permeation behavior in PAMPA assay. The synergistic effects
of S. baicalensis radix lyophilized extract and chitosan toward ferrous ion-
chelating activity, inhibition of hyaluronidase, and pathogen growth were observed.
The thermosensitive gelling system showed shear-thinning properties, gelation
temperature between 25 and 27 °C, and favorable mucoadhesiveness in contact with
porcine buccal mucosa, which was enhanced in the presence of binary mixture of S.
baicalensis radix extract and chitosan. The release tests showed that baicalin and
baicalein were liberated in a prolonged manner with a fast onset from hydrogel
formulations.
AN - rayyan-563559946
AU - Chanaj-Kaczmarek, J.
AU - Osmałek, T.
AU - Szymańska, E.
AU - Winnicka, K.
AU - Karpiński, T. M.
AU - Dyba, M.
AU - Bekalarska-Dębek, M.
DO - 10.3390/ijms222111319
IS - 21
KW - alginic acid
baicalein
baicalin
cellulose derivative
chitosan
ferrous ion
hyaluronidase
hydrogel
poloxamer
Scutellaria baicalensis extract
wogonin
animal tissue
article
attenuated total reflectance Fourier transform infrared spectroscopy
buccal mucosa
controlled study
drug potentiation
enzyme inhibition
flow kinetics
freeze drying
gelation
heat sensitivity
in vitro study
iron chelation
membrane permeability
mucoadhesion
nonhuman
periodontal disease
physical chemistry
pig
Scutellaria baicalensis
shear stress
viscosity
LA - English
PY - 2021
SN - ["1422-0067", "1661-6596"]
ST - Development and evaluation of thermosensitive hydrogels with binary mixture
of scutellariae baicalensis radix extract and chitosan for periodontal diseases
treatment
T2 - Int. J. Mol. Sci.
TI - Development and evaluation of thermosensitive hydrogels with binary mixture
of scutellariae baicalensis radix extract and chitosan for periodontal diseases
treatment
VL - 22
ID - 13320
ER -
TY - JOUR
AB - Background & objectives: Prevention of the periodontal disease progression is
the primary goal of periodontal therapy. When conventional therapy is found
inadequate to attain periodontal health in Chronic Periodontitis, local
antimicrobial agents have been used as an adjunct with scaling and root planing
which have reproduced encouraging results. This case series evaluates the newly
released sustained local drug Chlosite clinically & microbiologically in smokers.
Method: The patients were grouped into experimental group A treated with scaling
and root planning plus Chlosite (SRP + CHL), experimental group B treated with
Chlosite alone (CHL) and control group C treated only with scaling and root planing
(SRP) alone. A total number of 74 sites from 3 chronic smoker patients participated
in this study. The clinical parameters, Plaque index (PI), Gingival index (GI),
Bleeding index (BI) and Relative attachment level (RAL), were recorded and
microbiological samples taken before scaling and root planning. Results: All the
groups, showed statistically significant reduction in relation to Plaque index,
Bleeding index & relative attachment level. Combination of scaling and root
planning with chlosite resulted in added benefits as compared to the two treatment
groups. All the groups showed reduction in the microbial count of fusobacterium
nucleatum, Porphromonas gingivalis and tannerella forsythesis. Interpretation and
conclusion: In this study all treatment groups were found to be efficacious in the
treatment of periodontal disease as demonstrated by improvement in PI, GI, BI and
RAL. Combination of SRP and Chlosite resulted in added benefits compared to the two
treatment groups.
AN - rayyan-563560635
AU - Chandra, C.
AU - Chandra, S.
IS - 2
KW - chlorhexidine
chlosite
unclassified drug
xanthan
adult
article
bacterial count
Bleeding index
case report
controlled study
female
gingiva index
human
male
nonhuman
plaque index
Relative attachment level
scoring system
smoking
treatment outcome
LA - English
PY - 2010
SN - ["0973-9122", "0973-9130"]
SP - 39-41
ST - Effect of chlosite (xanthan gel with chlorhexidine) on clinical &
microbiological parameters in smokers- A case series
TI - Effect of chlosite (xanthan gel with chlorhexidine) on clinical &
microbiological parameters in smokers- A case series
VL - 4
ID - 14009
ER -
TY - JOUR
AN - rayyan-563561888
AU - Chandra, C.
AU - Valavalkar, N.
AU - Vandana, K.
DO - 10.4103/0972-124X.85664
IS - 3
PY - 2011
SP - 221-227
ST - The comparative evaluation of xanthan gel with chlorhexidine (Chlosite) in
smokers and non-smokers: A clinical and microbiological assessment
TI - The comparative evaluation of xanthan gel with chlorhexidine (Chlosite) in
84865514091&doi=10.4103%2f0972-
124X.85664&partnerID=40&md5=1bd181133faadc320120bf232af6927c
VL - 15
ID - 15262
ER -
TY - JOUR
AB - BACKGROUND AND OBJECTIVES: Prevention of the periodontal disease progression
is the primary goal of periodontal therapy. When conventional therapy is found
inadequate to attain periodontal health in chronic periodontitis, local
antimicrobial agents have been used as an adjunct with scaling and root planning
(SRP) which has reproduced encouraging results. Hence, this study was undertaken to
evaluate the new sustained released local drug Chlosite clinically and
microbiologically in smokers and non-smokers. MATERIALS AND METHODS: The patients
were grouped into experimental group A treated with SRP plus Chlosite (SRP + CHL),
experimental group B treated with Chlosite alone (CHL), and control group C treated
only with SRP alone. A total number of 141 sites from six patients (67 sites from
three non-smoker patients and 74 sites from three smoker patients) participated in
this study. The clinical parameters, Plaque index (PI), Gingival index (GI),
Bleeding index (BI), and Relative attachment level (RAL), were recorded and
subgingival plaque samples were collected and subjected to microbiological
analysis. RESULTS: On comparison of smokers and non-smokers, in SRP group, non-
smokers showed a higher reduction in BI and GI and smokers showed a higher
reduction in PI. There was no significant gain in RAL of both smokers and non-
smokers. In SRP + CHL group, non-smokers showed a higher reduction in relation to
BI and GI and smokers showed a higher reduction in relation to PI. There was no
significant gain in RAL of both smokers and non-smokers. In CHL group, both smokers
and non-smokers showed a nonsignificant reduction in BI, GI, and RAL, but smokers
showed a significant reduction in PI as compared with non-smokers. All the groups
showed reduction in the microbial count of Fusobacterium nucleatum, Porphyromonas
gingivalis, and Tannerella forsythia which were found to be statistically not
significant when it was compared between non-smokers and smokers. INTERPRETATION
AND CONCLUSION: In this study, all treatment groups were found to be efficacious in
the treatment of periodontal disease as demonstrated by improvement in PI, GI, BI,
and RAL. Combination of SRP and Chlosite resulted in added benefits compared with
the two treatment groups.
AN - rayyan-563561262
AU - Chandra, C.
AU - Valavalkar, N.
AU - Vandana, K. L.
DO - 10.4103/0972-124X.85664
IS - 3
LA - eng
N1 - Department of Periodontics, Sardar Patel Post Graduate Institute of Dental
and Medical Sciences, Lucknow, Uttar Pradesh, India.
PY - 2011
SP - 221-7
ST - The comparative evaluation of xanthan gel with chlorhexidine (Chlosite) in
TI - The comparative evaluation of xanthan gel with chlorhexidine (Chlosite) in
VL - 15
Y2 - 7
ID - 14636
ER -
TY - JOUR
AB - The present study was carried out as a multicenter, randomized controlled,
split-mouth clinical trial to evaluate the efficacy of locally delivered lycopene
on periodontal health and gingival crevicular fluid (GCF) levels of 8-
hydroxydeoxyguanosine (8-OHdG) in smokers and nonsmokers compared with
periodontally healthy control subjects. One hundred ten subjects including 50
smokers, 50 nonsmokers, and 10 controls participated in this study. Subjects in the
smoker and nonsmoker groups had contralateral sites treated with lycopene gel and a
placebo. Clinical parameters included recording site-specific measures of plaque,
gingivitis, probing depth, and clinical attachment level. GCF 8-OHdG values were
analyzed using a commercially available ELISA kit. Compared with the placebo,
lycopene-treated sites in smokers and nonsmokers showed significant reductions in
probing depths and gain in the clinical attachment levels. However, there was no
statistically significant difference in the clinical parameters when lycopene-
treated sites in smokers and nonsmokers were compared, except for the reduction in
the 8-OHdG levels. The 8-OHdG levels at 1 week and 3 months in sites treated with
lycopene in the smoker and nonsmoker group were comparable with those in the
periodontally healthy control group. The gel formulation was effective in
increasing clinical attachment and reducing gingival inflammation, probing depth,
and oxidative injury compared with the placebo in smoking and nonsmoking subjects.
AN - rayyan-563560550
AU - Chandra, R. V.
AU - Sandhya, Y. P.
AU - Nagarajan, S.
AU - Reddy, B. H.
AU - Naveen, A.
AU - Murthy, K. R.
IS - 5
KW - 8 hydroxydeoxyguanosine
antioxidant
carotenoid
deoxyguanosine
drug derivative
lycopene
placebo
adult
article
chemistry
clinical trial
comparative study
controlled study
drug effect
follow up
gel
gingivitis
human
male
middle aged
multicenter study
oxidative stress
periodontal disease
periodontal pocket
periodontics
smoking
tooth plaque
treatment outcome
LA - English
PY - 2012
SN - 1936-7163
SP - 401-411
ST - Efficacy of lycopene as a locally delivered gel in the treatment of chronic
periodontitis: smokers vs nonsmokers
TI - Efficacy of lycopene as a locally delivered gel in the treatment of chronic
periodontitis: smokers vs nonsmokers
VL - 43
ID - 13924
ER -
TY - JOUR
AB - It has been reported that GroEL, a heat shock protein (HSP) produced by the
representative periodontopathogenic bacterium, Porphyromonas gingivalis, induces
inflammation-induced osteoclastogenesis and promotes alveolar bone resorption. In
this study, we demonstrated the efficacy of a mucosal vaccine targeting GroEL
against bone resorption induced by P. gingivalis. Female BALB/c mice received
sublingual CpG oligodeoxynucleotide as an adjuvant with recombinant GroEL (rGroEL)
prior to P. gingivalis exposure. Animals were euthanized 30 days after P.
gingivalis inoculation. Sublingual immunization (SLI) with rGroEL elicited
significant rGroEL-specific serum immunoglobulin (Ig)G and salivary IgA antibody
(Ab) responses, and these responses were sustained for approximately 1 year.
Interestingly, 10-fold more GroEL-specific IgA Ab-producing cells were detected in
the submandibular glands (SMGs) than in the spleen. Antigen (Ag)-specific cells
isolated from the spleen and SMGs induced significantly higher levels of IFN-γ
expression after Ag restimulation in vitro. Flow cytometry illustrated that the
frequency of CD11b+ dendritic cells with enhanced expression of CD80, CD86, CD40,
and major histocompatibility complex II molecules was significantly increased in
the SMGs. Furthermore, SLI with rGroEL significantly suppressed P. gingivalis-
induced alveolar bone resorption and P. gingivalis-stimulated tumor necrosis
factor-α, interleukin-6, and HSP60 expression in the gingiva. These findings
suggest that SLI with rGroEL and CpG oligodeoxynucleotide is a beneficial strategy
for preventing periodontal disease, mainly by presenting Ags in the oral region and
inducing antibody production in the mucosal and systemic systems.
AN - rayyan-563559867
AU - Chang, E.
AU - Kobayashi, R.
AU - Hagiwara-Hamano, M.
AU - Kurita-Ochiai, T.
AU - Komiya, M.
DO - 10.1111/omi.12358
IS - 2
KW - polymerase chain reaction system
B7 antigen
CD11b antigen
CD40 antigen
CD86 antigen
chaperonin 60
gamma interferon
immunoglobulin A antibody
interleukin 6
adult
alveolar bone
alveolar bone loss
animal cell
animal experiment
animal model
animal tissue
article
bacterial strain
bacterium culture
cell population
controlled study
enzyme linked immunospot assay
female
flow cytometry
gingival tissue
immunoglobulin blood level
immunoglobulin producing cell
in vitro study
inflammation
major histocompatibility complex
mouse
mouth infection
nonhuman
osteolysis
protein expression
submandibular gland
vaccination
Western blotting
LA - English
PY - 2022
SN - ["2041-1014", "2041-1006"]
SP - 31-41
ST - Sublingual immunization with recombinant GroEL plus CpG-ODN inhibits
Porphyromonas gingivalis-induced inflammation and alveolar bone loss
TI - Sublingual immunization with recombinant GroEL plus CpG-ODN inhibits
Porphyromonas gingivalis-induced inflammation and alveolar bone loss
VL - 37
ID - 13241
ER -
TY - JOUR
AB - This study was performed to design a hydrogel membrane that exhibits
antibacterial properties and guides different tissues. Gelatin and hyaluronic acid
were used as the main structures, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide
hydrochloride (EDC) was used as a cross-linker, and temoporfin was used as an
antibacterial agent. The results revealed that the hydrogel membrane impregnated
with temoporfin (HM-T) had a fixation index of >89%. Temoporfin was used in
conjunction with a diode laser and did not significantly affect EDC-induced cross-
linking. The inhibitory activity of temoporfin showed that HM-T15 and HM-T30 (light
exposure for 15 and 30 min, respectively) had remarkable antibacterial properties.
The cell survival rate of HM-T15 was 73% of that of the control group, indicating
that temoporfin exposure for 15 min did not exert cytotoxic effects on L-929 cells.
HM and HM-T15 hydrogel membranes showed good cell adhesion and proliferation after
14 days of dark incubation. However, the hydrogel membrane containing temoporfin
significantly reduced pro-inflammatory gene expression. In summary, the HM-T15
group showed potential as a biodegradable material for biocompatible tissue-guarded
regeneration membranes with antibacterial properties. This study demonstrated the
potential of temoporfin for innovative biomaterials and delivery systems applied to
new regenerative periodontal therapies.
AN - rayyan-563559794
AU - Chang, K. C.
AU - Chiu, K. C.
AU - Chen, W. C.
AU - Lan, W. C.
AU - Chen, C. Y.
AU - Hsia, S. M.
AU - Wang, T. H.
AU - Tu, H. F.
AU - Shih, Y. H.
AU - Shieh, T. M.
IS - 11
KW - diode laser
1 (3 dimethylaminopropyl) 3 ethylcarbodiimide
gelatin
hyaluronic acid
hydrogel
temoporfin
animal cell
article
biocompatibility
biodegradability
cell adhesion
cell proliferation
cell survival rate
chemical parameters
controlled study
cross linking
cytotoxicity
fixation index
gene expression
hydrogel membrane
in vitro study
incubation time
light exposure
mouse
NCTC clone 929 cell line
nonhuman
periodontal disease
periodontium
tissue regeneration
LA - English
PY - 2022
SN - 1999-4923
ST - Effects of Temoporfin-Based Photodynamic Therapy on the In Vitro
Antibacterial Activity and Biocompatibility of Gelatin-Hyaluronic Acid Cross-Linked
Hydrogel Membranes
T2 - Pharmaceutics
TI - Effects of Temoporfin-Based Photodynamic Therapy on the In Vitro
Antibacterial Activity and Biocompatibility of Gelatin-Hyaluronic Acid Cross-Linked
Hydrogel Membranes
VL - 14
ID - 13168
ER -
TY - JOUR
AB - Matrix metalloproteinases (MMPs). produced by both infiltrating and resident
cells of the periodontium, play a role in physiologic and pathologic events. It is
recognized that an imbalance between activated MMPs and their endogenous inhibitors
leads to pathologic breakdown of the extracellular matrix during periodontitis. To
date, little is known about the regulation of MMP synthesis and secretion in human
periodontal ligament fibroblasts (PDLFs). The purpose of this study was to examine
the effects of cytokines, pharmacological agents (protein synthesis inhibitor and
protein kinase C inhibitors) and predominant periodontal pathogens (Actinobacillus
actinomycetemcomitans and Porphyromonas gingivalis) on MMP production in human
PDLFs using gelatin zymography. The gelatin zymograms revealed that the main
gelatinase secreted by human PDLFs migrated at 72 kDa and represents MMP-2. Minor
gelatinolytic bands were also observed at 92 kDa regions that correspond to MMP-9.
We found that A. actinomycetemcomitans, P. gingivalis and IL-1alpha can elevate
MMP-2 secretion in human PDLFs. These results indicate that periodontal pathogens
and inflammatory cytokines play an important role in tissue destruction and
disintegration of extracellular matrix in periodontal diseases. Thus, activation of
MMPs may be one of the distinct host degradative pathways in the pathogenesis of
periodontitis. In addition, H7, staurosporine, cycloheximide and TGF-beta could
suppress MMP-2 production. Agents that target protein synthesis or the protein
kinase C pathway in human PDLFs inhibit MMP-2 production, and such inhibition may
contribute to the pathogenesis of periodontal inflammation. Taken together, these
findings suggest a possible new therapeutic approach, involving the use of drugs
that modify host-response mechanisms to suppress or inhibit MMP-mediated tissue
destruction.
AN - rayyan-563560905
AU - Chang, Y. C.
AU - Yang, S. F.
AU - Lai, C. C.
AU - Liu, J. Y.
AU - Hsieh, Y. S.
IS - 3
KW - 1 (5 isoquinolinesulfonyl) 2 methylpiperazine
cycloheximide
enzyme inhibitor
gelatinase A
interleukin 1
protein kinase C
protein synthesis inhibitor
staurosporine
article
biosynthesis
cell culture
cytology
drug antagonism
drug effect
enzymology
fibroblast
gene expression regulation
human
microbiology
pathogenicity
periodontal disease
LA - English
PY - 2002
SN - 0022-3484
SP - 196-203
ST - Regulation of matrix metalloproteinase production by cytokines,
pharmacological agents and periodontal pathogens in human periodontal ligament
fibroblast cultures
TI - Regulation of matrix metalloproteinase production by cytokines,
pharmacological agents and periodontal pathogens in human periodontal ligament
fibroblast cultures
VL - 37
ID - 14279
ER -
TY - JOUR
AB - Background and Objective: Acemannan, a polysaccharide extracted from aloe
vera gel, accelerates oral wound healing, reparative dentin formation, and bone
formation in extraction sockets. In this report, we evaluated the efficacy of
combined acemannan and periodontal surgery on periodontal regeneration in severe
periodontitis cases requiring periodontal surgery. Case Presentation and
Discussion: Three chronic periodontitis patients with probing pocket depths of at
least 6 mm and two-or three-walled vertical bone defects after initial periodontal
therapy were included. The patients underwent minimally invasive periodontal
surgery with acemannan sponges placed in the defect. Maintenance recall was
scheduled every 6 months for 5 years. Clinical and radiographic evaluations were
performed to assess the effects of the combined acemannan and periodontal surgery
on periodontal regeneration. The patients demonstrated improved clinical parameters
and increased radiographic bone fill at the 5-year follow-ups. The percentage bone
fill in the three-walled defect, combined two-and three-walled defect, and two-
walled defect cases were 70%, 60%, and 20%, respectively. The underlying mechanism
of action of acemannan in periodontal regeneration was also discussed. Conclusion:
Acemannan sponges can be used as an adjunct to periodontal surgery for periodontal
regeneration.
AN - rayyan-563559769
AU - Chansamart, R.
AU - Sangvanich, P.
AU - Thunyakitpisal, P.
DO - 10.2174/18742106-v17-e230124-2022-75
IS - 1
KW - nonabsorbable suture
acemannan
ibuprofen
adult
article
bone defect
case report
clinical article
clinical assessment
clinical evaluation
dental scaling
female
follow up
gamma irradiation
human
male
middle aged
mouth examination
periodontitis
radiography
suture removal
tooth radiography
LA - English
PY - 2023
SN - 1874-2106
ST - Clinical and Radiographic Evaluation of Combined Acemannan and Periodontal
Surgery Induced-Periodontal Regeneration: 5-Year Follow-up Case Report
T2 - Open Dent. J.
TI - Clinical and Radiographic Evaluation of Combined Acemannan and Periodontal
Surgery Induced-Periodontal Regeneration: 5-Year Follow-up Case Report
VL - 17
ID - 13143
ER -
TY - JOUR
AB - An antimicrobial agent-loaded in situ-forming gel (ISG) was recently used for
periodontitis treatment. This study aimed to use lauric acid, a biocompatible
hydrophobic material, as a matrix former. Non-drug and vancomycin HCl-loaded lauric
acid-based ISGs were prepared by using various solvents, including N-methyl
pyrrolidone, 2-pyrrolidone and dimethyl sulphoxide (DMSO). Increased concentrations
of lauric acid resulted in faster gel self-transformation behaviour. The ISG using
DMSO as the solvent showed the fastest transformation with the least water
tolerance. Higher concentrations of lauric acid promoted the immediate formation of
a dense lauric acid network on the gel surface and obstructed water/solvent
diffusion. Through the solvent-exchange mechanism, the hydrophobic property of
lauric acid and its rapid surface network formation retarded the diffusion of
vancomycin HCl, resulting in prolonged drug release over 6 days. Vancomycin HCl-
loaded ISG revealed effective antimicrobial activity against methicillin-resistant
Staphylococcus aureus and Porphyromonas gingivalis for periodontitis treatment. All
of the preparations exhibited low viscosity and high injectability, thereby
indicating their ease of use. The developed system was found to be effective for
periodontal pocket drug delivery for periodontitis treatment.
AN - rayyan-563560118
AU - Chantadee, T.
AU - Santimaleeworagun, W.
AU - Phorom, Y.
AU - Chuenbarn, T.
AU - Phaechamud, T.
DO - 10.1016/j.jddst.2020.101615
2 pyrrolidinone
dimethyl sulfoxide
gel
in situ forming gel
lauric acid
unclassified drug
vancomycin
water
article
drug formulation
hydrophobicity
nonhuman
periodontitis
pH
phase separation
physical chemistry
LA - English
PY - 2020
SN - 1773-2247
ST - Vancomycin HCl-loaded lauric acid in situ-forming gel with phase inversion
for periodontitis treatment
TI - Vancomycin HCl-loaded lauric acid in situ-forming gel with phase inversion
VL - 57
ID - 13492
ER -
TY - CPAPER
AB - In situ forming depot (ISD) is a liquid drug delivery formulation generating
solid depot after injection via a syringe into the body. The 5% w/w doxycycline
hyclate (DH)-incorporated poly (ethyl acrylate, methyl methacrylate,
trimethylammonioethyl methacrylate chloride) (Eudragit RS) ISD systems comprising
clove oil (CO) dissolved in N-methyl pyrrolidone (NMP) were prepared and evaluated
for their fluid properties (density, viscosity, injectability and thermal
properties) and phase transition (depot formation, mechanical properties). The
higher weight percentage of Eudragit RS and CO apparently enhanced the viscosity of
the prepared ISDs. The rapid in vitro depot formation owing to solvent exchange was
evident for ISD containing higher NMP amount whereas higher CO amount retarded the
phase transition. The easier injectability and more efficient antimicrobial
activities corresponded with lower viscosity of ISD comprising higher content of
NMP and vice versa for CO content. ISDs exhibited a plastic deformation with rather
low F-remaining/F-max deformation ratio and efficiently inhibited the test bacteria
and fungi. Thus, DH-loaded Eudragit RS /CO ISD shows as a potential local delivery
system for periodontitis treatment. Copyright (c) 2022 Elsevier Ltd. All rights
reserved. Selection and peer-review under responsibility of the scientific
committee of the Joint International Conference on Applied Physics and Materials
Applications & Applied Magnetism and Ferroelectrics.
AN - rayyan-563562515
AU - Chantadee, T.
AU - Thammasut, W.
AU - Phaechamud, T.
DO - 10.1016/j.matpr.2022.04.920
PY - 2022
SP - 2296-2302
T2 - MATERIALS TODAY-PROCEEDINGS
TI - Fluid properties and phase transition of antimicrobial eudragit RS/clove oil
in situ forming depot
VL - 65
ID - 15889
ER -
TY - JOUR
AB - BACKGROUND AND OBJECTIVE: Periodontal disease is a common infectious disease,
found worldwide, causing the destruction of the periodontium. The periodontium is a
complex structure composed of both soft and hard tissues, thus an agent applied to
regenerate the periodontium must be able to stimulate periodontal ligament,
cementum and alveolar bone regeneration. Recent studies demonstrated that
acemannan, a polysaccharide extracted from Aloe vera gel, stimulated both soft and
hard tissue healing. This study investigated effect of acemannan as a bioactive
molecule and scaffold for periodontal tissue regeneration. MATERIAL AND METHODS:
Primary human periodontal ligament cells were treated with acemannan in vitro. New
DNA synthesis, expression of growth/differentiation factor 5 and runt-related
transcription factor 2, expression of vascular endothelial growth factor, bone
morphogenetic protein-2 and type I collagen, alkaline phosphatase activity, and
mineralized nodule formation were determined using [(3)H]-thymidine incorporation,
reverse transcription-polymerase chain reaction, enzyme-linked immunoabsorbent
assay, biochemical assay and alizarin red staining, respectively. In our in vivo
study, premolar class II furcation defects were made in four mongrel dogs.
Acemannan sponges were applied into the defects. Untreated defects were used as a
negative control group. The amount of new bone, cementum and periodontal ligament
formation were evaluated 30 and 60 d after the operation. RESULTS: Acemannan
significantly increased periodontal ligament cell proliferation, upregulation of
growth/differentiation factor 5, runt-related transcription factor 2, vascular
endothelial growth factor, bone morphogenetic protein 2, type I collagen and
alkaline phosphatase activity, and mineral deposition as compared with the
untreated control group in vitro. Moreover, acemannan significantly accelerated new
alveolar bone, cementum and periodontal ligament formation in class II furcation
defects. CONCLUSION: Our data suggest that acemannan could be a candidate
biomolecule for periodontal tissue regeneration.
AN - rayyan-563560428
AU - Chantarawaratit, P.
AU - Sangvanich, P.
AU - Banlunara, W.
AU - Soontornvipart, K.
AU - Thunyakitpisal, P.
DO - 10.1111/jre.12090
IS - 2
KW - acemannan
collagen type 1
DNA
gel
growth differentiation factor 5
mannan
plant extract
transcription factor RUNX2
vasculotropin A
animal
bone development
bone mineralization
bone regeneration
cell culture
cell proliferation
tooth cementum
cytology
disease model
dog
drug effect
periodontal disease
human
jaw
phytotherapy
procedures
regeneration
tooth development
LA - English
PY - 2014
SN - 1600-0765
SP - 164-178
ST - Acemannan sponges stimulate alveolar bone, cementum and periodontal ligament
regeneration in a canine class II furcation defect model
TI - Acemannan sponges stimulate alveolar bone, cementum and periodontal ligament
regeneration in a canine class II furcation defect model
VL - 49
ID - 13802
ER -
TY - JOUR
AB - The aim of this study was to evaluate the effects of a gel containing 4%
metronidazole and collagen in periodontal pockets deeper than 4 mm. The treatment
was utilized in 10 subjects with pocketing in the premolar-molar regions. The
experimental design was as follows: one quadrant was treated with scaling and root
planning (S), one with the metronidazole gel (M), one with scaling, root planning
and metronidazole gel (S & M), and the last quadrant remained untreated. Pocket
depths, gingival index (GI), sulcular bleeding index (SBI) and plaque indices were
recorded at 7, 14 and 30 days after the experiment began. Significant improvement
of the parameters studied was noted in the S & M quadrants.
AN - rayyan-563561173
AU - Charbit, Y.
AU - Hitzig, C.
AU - Lapougeas, J. C.
AU - Teboul, M.
AU - Bitton-Sebag, C.
IS - 4
KW - metronidazole
adult
article
female
gel
human
male
middle aged
periodontitis
tooth root
LA - French
PY - 1989
SN - 0750-1838
SP - 367-373
ST - Experimental study of a metronidazole gel inserted in periodontal pockets
T2 - Etude expérimentale d'un gel de metronidazole inséré dans des poches
parodontales.
TI - Experimental study of a metronidazole gel inserted in periodontal pockets
VL - 8
ID - 14547
ER -
TY - JOUR
AB - OBJECTIVE: Periodontitis initiation and progression are a result of host
immune inflammatory response to oral pathogens. Several pharmacological agents are
being delivered locally, to improve periodontal health. Hence, the present
randomized placebo controlled clinical trial is designed to check the clinical and
antimicrobial efficacy of locally delivered 1.2% rosuvastatin (RSV) in intrabony
defects (IBD) in periodontitis patients. MATERIALS AND METHODS: One-hundred
patients were randomly allotted into two treatment groups: group A received 1. 2%
RSV gel, scaling and root debridement and group B received placebo gel, scaling and
root debridement. Clinical parameters, including modified sulcus bleeding index
(mSBI), probing depth (PD), clinical attachment level (CAL), and plaque index (PI),
were recorded at baseline before phase 1 and after 6 months. Radiographic
assessment of IBD was done by cone beam computed tomography at baseline and after 6
months. Anaerobic colony count was done at baseline and after 180 days. RESULTS: On
intragroup comparison, there is a significant improvement in periodontal parameters
in both the groups. On intergroup comparison, there is significant gain in CAL in
group A than group B (p = 0.04). There is significant decrease in PD in group A,
compared to group B. There is significant bone fill in group A (p = 0.034),
compared to group B. With respect to mSBI, PI, and anaerobic colony count, there is
no significant difference between the two groups after 6 months. No adverse effect
was noticed in any subjects. CONCLUSION: The author concludes that 1.2% RSV gel
when delivered locally into IBD improved periodontal clinical parameters such as PD
and CAL and showed significant bone fill.
AN - rayyan-563561306
AU - Chatterjee, D.
AU - Kapoor, A.
AU - Vijay, S.
AU - Sobti, G.
AU - Kara, D.
AU - Thanvi, J.
DO - 10.1055/s-0039-1688522
IS - 1
J2 - Eur J Dent
LA - eng
N1 - Department of Periodontics, College of Dental Sciences, Rajasthan University
of Health Sciences, Jaipur, Rajasthan, India.; Department of Periodontics, College
of Dental Sciences, Rajasthan University of Health Sciences, Jaipur, Rajasthan,
India.; Department of Periodontics, College of Dental Sciences, Rajasthan
University of Health Sciences, Jaipur, Rajasthan, India.; Department of Oral
Medicine, Radiology and Diagnosis, College of Dental Sciences, Rajasthan University
of Health Sciences, Jaipur, Rajasthan, India.; Department of Public Health, YMT
Dental College, Navi Mumbai, Maharashtra, India.; Department of Oral Medicine,
Radiology and Diagnosis, College of Dental Sciences, Rajasthan University of Health
Sciences, Jaipur, Rajasthan, India.
PY - 2019
SN - 1305-7456 (Print)
SP - 29-35
ST - Efficacy of Locally Administered 1.2% Rosuvastatin Gel in Patients with
Periodontitis: A Randomized Placebo Controlled Clinical Trial
T2 - European journal of dentistry
TI - Efficacy of Locally Administered 1.2% Rosuvastatin Gel in Patients with
VL - 13
Y2 - 2
ID - 14680
ER -
TY - JOUR
AN - rayyan-563561773
AU - Chatterjee, D.
AU - Kapoor, A.
AU - Vijay, S.
AU - Sobti, G.
AU - Kara, D.
AU - Thanvi, J.
DO - 10.1055/s-0039-1688522
IS - 1
PY - 2019
SP - 29-35
ST - Efficacy of Locally Administered 12% Rosuvastatin Gel in Patients with
T2 - European Journal of Dentistry
TI - Efficacy of Locally Administered 12% Rosuvastatin Gel in Patients with
85068065235&doi=10.1055%2fs-0039-
1688522&partnerID=40&md5=c7026b808c5e2cdf88ce52af132d6056
VL - 13
ID - 15147
ER -
TY - JOUR
AB - Background: The use of herbal products in oral cavity has shown an increased
popularity and potential benefits due to their additional anti-inflammatory and
antioxidant properties as well as the lack of side effects related to their use.
Objective: To assess the clinical effectiveness of herbal dental products
(mouthwash, dentifrice, gel) when compared to conventional products or placebo in
periodontitis patients. Material and methods: A systematic review with 22 studies
was carried out using MEDLINE/Pubmed, EMBASE and Web of Science databases in
addition to hand searches. Randomized and non-randomized clinical trials that
evaluated the effect of any herbal dental product and compared it with conventional
products or placebo in periodontitis patients and published up to March 2022, were
screened. Results: Herbal products used as adjuncts to scaling and root planing
(SRP) or supragingival debridement (SPD) led to superior clinical outcomes than
placebo or no adjuncts (8 studies). In conjunction with SRP, these products showed
comparable outcomes with chlorhexidine (6 studies) or better (4 studies). When used
as adjuncts to SPD, herbal oral care products demonstrated comparable outcomes with
chlorhexidine and conventional products (4 studies). Conclusions: Within the
limitations of this systematic review, herbal oral care products may play a key
role in the management of periodontal disease. Further well-designed studies are
needed to establish their efficacy.
AN - rayyan-563559816
AU - Chatzopoulos, G. S.
AU - Karakostas, P.
AU - Kavakloglou, S.
AU - Assimopoulou, A.
AU - Barmpalexis, P.
AU - Tsalikis, L.
DO - 10.3390/ijerph191610061
IS - 16
KW - chlorhexidine
Glycyrrhiza glabra root
mouthwash
toothpaste
Cymbopogon citratus
disease severity
gingivitis
ginseng
herbal medicine
human
Matricaria chamomilla
mouth hygiene
nonhuman
Ocimum tenuiflorum
periodontitis
phytotherapy
review
root planing
systematic review
tea
LA - English
PY - 2022
SN - ["1660-4601", "1661-7827"]
ST - Clinical Effectiveness of Herbal Oral Care Products in Periodontitis
Patients: A Systematic Review
TI - Clinical Effectiveness of Herbal Oral Care Products in Periodontitis
Patients: A Systematic Review
VL - 19
ID - 13190
ER -
TY - JOUR
AB - A scaffold is comprised of the polymeric central components, which are used
to deliver cells, drugs, and genes into the body. Wounds, which lead to a loss of
integrity of the skin and skin mortality, are common challenges encountered in
plastic and reconstructive surgery. The primary goals of treatment are rapid
closure, restoration of function, and aesthetic satisfaction. A paradigm shift is
taking place in medicine from using synthetic implants and tissue grafts to a
tissue-engineering approach that uses degradable porous material scaffolds
integrated with biological cells or molecules to regenerate tissues. Scaffold
structure is a novel carrier for cell and drug delivery that enhances wound healing
through differentiation of endothelial and epithelial cells and production of
angiogenic growth factors in cutaneous wounds. Currently, scaffolds have
application in various fields of tissue engineering in repair of nasal and
auricular malformations, in bone formation, in cartilage development, in
periodontal regeneration, as artificial corneas, as heart valves, in ligament
replacement, in tendon repair, and in tumours. In the present review, we emphasize
the role of scaffolds in wound healing, and we outline types of scaffolds,
properties, techniques adopted, materials used, and their applications in tissue
engineering.
AN - rayyan-563560405
AU - Chaudhary, C.
AU - Garg, T.
DO - 10.1615/CritRevTherDrugCarrierSyst.2015011246
IS - 4
KW - alginic acid
cellulose acetate
chitin
chitosan
collagen
dextran
fibrinogen
fibroblast growth factor
gelatin
glycosaminoglycan
hyaluronic acid
interleukin 1
interleukin 6
macrogol
microsphere
molecular scaffold
nanofiber
platelet derived growth factor
polycaprolactone
polyglactin
polylactic acid
polyurethan
polyvinyl alcohol
pullulan
silk fibroin
unindexed drug
biocompatibility
biodegradability
cell proliferation
chemical procedures
electrospinning
external ear malformation
fiber bonding method
fiber mesh method
freeza drying method
gas foaming method
hemostasis
hydrogel
inflammation
melt molding method
ossification
phase seperation method
plastic surgery
porosity
powder compaction method
prototyping method
review
solvent casting method
supercritical fluid technology
surface property
thrombocyte
tissue engineering
tissue regeneration
wound healing
LA - English
PY - 2015
SN - ["2162-660X", "0743-4863"]
SP - 277-321
ST - Scaffolds: A novel carrier and potential wound healer
T2 - Crit. Rev. Ther. Drug Carrier Syst.
TI - Scaffolds: A novel carrier and potential wound healer
VL - 32
ID - 13779
ER -
TY - JOUR
AB - Background: Green tea extract is a naturally occurring antimicrobial agent,
consisting of polyphenols (catechin) with anticariogenic, anti-inflammatory,
anticollagenolytic properties. Hence, in the present study, an attempt was made to
develop a thermo-reversible sustained-release green tea gel and to study its
clinical effects on patients with chronic periodontitis (CP). Methods: Thermo-
reversible sustained-release green tea catechin gel was prepared and tested for its
in vitro release characteristics. An in vivo controlled, randomized, splitmouth
single-evaluator masked study was conducted. Thirty patients with two sites in the
contralateral quadrants having probing depths (PDs) of ≥4 mm were selected.
Assessment of gingival index (GI), PD, and relative clinical attachment levels
(rCALs) was done at baseline and at 4 weeks. Green tea and placebo gels were placed
at test and control sites as an adjunct to Phase 1 periodontal therapy. Results:
Comparison of the mean ± SD GI, PD, and rCAL values within the test group at
baseline (1.92 ± 0.24, 4.93 ± 0.58, and 9.97 ± 0.72, respectively) and the end of 4
weeks (0.01 ± 0.04, 2.87 ± 0.51, and 7.87 ± 0.51, respectively) showed high
statistical significance (P <0.001). Comparison of mean ± SD of GI, PD, and rCAL
within the control group at baseline (1.95 ± 0.16, 4.77 ± 0.50, and 9.73 ± 0.45,
respectively) and the end of 4 weeks (0.16 ± 0.11, 3.8 ± 0.48, and 8.76 ± 0.43,
respectively) showed significance with P <0.001. High significance was observed
between the delta of measurements (0 to 4 weeks) of GI, PD, and rCAL between test
(1.91 ± 0.20, 2.06 ± 0.07, and 2.1 ± 0.21, respectively) and control (1.79 ± 0.05,
0.97 ± 0.02, and 0.97 ± 0.02, respectively) groups. Conclusion: Adjunctive local
drug therapy with thermoreversible green tea gel has shown to reduce pockets and
inflammation during the 4 weeks of the clinical trial in patients with CP.
AN - rayyan-563560504
AU - Chava, V. K.
AU - Vedula, B. D.
DO - 10.1902/jop.2012.120425
IS - 9
KW - acrylic acid resin
antiinfective agent
carbomer
catechin
excipient
placebo
plant extract
poloxamer
adult
article
Camellia sinensis
chemistry
comparative study
controlled study
female
follow up
gel
human
male
methodology
periodontal disease
periodontal pocket
periodontics
phytotherapy
tea
LA - English
PY - 2013
SN - 0022-3492
SP - 1290-1296
ST - Thermo-reversible green tea catechin gel for local application in chronic
periodontitis: A 4-week clinical trial
TI - Thermo-reversible green tea catechin gel for local application in chronic
periodontitis: A 4-week clinical trial
VL - 84
ID - 13878
ER -
TY - COMP
AB - BACKGROUND: Green tea extract is a naturally occurring antimicrobial agent,
consisting of polyphenols (catechin) with anticariogenic, anti-inflammatory,
anticollagenolytic properties. Hence, in the present study, an attempt was made to
develop a thermo-reversible sustained-release green tea gel and to study its
clinical effects on patients with chronic periodontitis (CP). METHODS: Thermo-
reversible sustained-release green tea catechin gel was prepared and tested for its
in vitro release characteristics. An in vivo controlled, randomized, split-mouth
single-evaluator masked study was conducted. Thirty patients with two sites in the
contralateral quadrants having probing depths (PDs) of ≥4 mm were selected.
Assessment of gingival index (GI), PD, and relative clinical attachment levels
(rCALs) was done at baseline and at 4 weeks. Green tea and placebo gels were placed
at test and control sites as an adjunct to Phase 1 periodontal therapy. RESULTS:
Comparison of the mean ± SD GI, PD, and rCAL values within the test group at
baseline (1.92 ± 0.24, 4.93 ± 0.58, and 9.97 ± 0.72, respectively) and the end of 4
weeks (0.01 ± 0.04, 2.87 ± 0.51, and 7.87 ± 0.51, respectively) showed high
statistical significance (P <0.001). Comparison of mean ± SD of GI, PD, and rCAL
within the control group at baseline (1.95 ± 0.16, 4.77 ± 0.50, and 9.73 ± 0.45,
respectively) and the end of 4 weeks (0.16 ± 0.11, 3.8 ± 0.48, and 8.76 ± 0.43,
respectively) showed significance with P <0.001. High significance was observed
between the delta of measurements (0 to 4 weeks) of GI, PD, and rCAL between test
(1.91 ± 0.20, 2.06 ± 0.07, and 2.1 ± 0.21, respectively) and control (1.79 ± 0.05,
0.97 ± 0.02, and 0.97 ± 0.02, respectively) groups. CONCLUSION: Adjunctive local
drug therapy with thermo-reversible green tea gel has shown to reduce pockets and
inflammation during the 4 weeks of the clinical trial in patients with CP.
AN - rayyan-563561366
AU - Chava, V. K.
AU - Vedula, B. D.
CY - United States
DO - 10.1902/jop.2012.120425
ET - 9
J2 - J Periodontol
KW - Acrylic Resins/chemistry
Adult
Anti-Bacterial Agents/*administration & dosage
*Camellia sinensis
Catechin/*administration & dosage
Chronic Periodontitis/*drug therapy
*Drug Delivery Systems
Excipients/chemistry
Female
Follow-Up Studies
Gels
Humans
Male
Periodontal Attachment Loss/drug therapy
Periodontal Index
Periodontal Pocket/drug therapy
Phytotherapy/*methods
Placebos
Plant Extracts/*administration & dosage
Poloxamer/chemistry
Single-Blind Method
Tea
LA - eng
N1 - Department of Periodontology, Narayana Dental College and Hospital, Nellore,
Andhra Pradesh, India. chava7@hotmail.com
PY - 2013
SP - 1290-6
ST - Thermo-reversible green tea catechin gel for local application in chronic
periodontitis: a 4-week clinical trial
T2 - Journal of periodontology
TI - Thermo-reversible green tea catechin gel for local application in chronic
periodontitis: a 4-week clinical trial
VL - 84
Y2 - 9
ID - 14740
ER -
TY - JOUR
AB - Oral health is crucial to daily life, yet many people worldwide suffer from
oral diseases. With the development of oral tissue engineering, there is a growing
demand for dental biomaterials. Addressing oral diseases often requires a two-fold
approach: fighting bacterial infections and promoting tissue growth. Hydrogels are
promising tissue engineering biomaterials that show great potential for oral tissue
regeneration and drug delivery. In this review, we present a classification of
hydrogels commonly used in dental research, including natural and synthetic
hydrogels. Furthermore, recent applications of these hydrogels in endodontic
restorations, periodontal tissues, mandibular and oral soft tissue restorations,
and related clinical studies are also discussed, including various antimicrobial
and tissue growth promotion strategies used in the dental applications of
hydrogels. While hydrogels have been increasingly studied in oral tissue
engineering, there are still some challenges that need to be addressed for
satisfactory clinical outcomes. This paper summarizes the current issues in the
abovementioned application areas and discusses possible future developments.
AN - rayyan-563560818
AU - Chen, A.
AU - Deng, S.
AU - Lai, J.
AU - Li, J.
AU - Chen, W.
AU - Varma, S. N.
AU - Zhang, J.
AU - Lei, C.
AU - Liu, C.
AU - Huang, L.
DO - 10.3390/molecules28093946
IS - 9
J2 - Molecules
KW - Humans
Biocompatible Materials/pharmacology
*Hydrogels/pharmacology
Periodontium
*Tissue Engineering
LA - eng
N1 - Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter,
School of Materials and Energy, Guangdong University of Technology, Guangzhou
510006, China.; Institute of Orthopaedics and Musculoskeletal Science, Division of
Surgery and Interventional Science, University College London, Royal National
Orthopaedic Hospital, London HA4 4LP, UK.; Guangdong Provincial Key Laboratory of
Functional Soft Condensed Matter, School of Materials and Energy, Guangdong
University of Technology, Guangzhou 510006, China.; Guangdong Provincial Key
Laboratory of Functional Soft Condensed Matter, School of Materials and Energy,
Guangdong University of Technology, Guangzhou 510006, China.; Guangdong Provincial
Key Laboratory of Functional Soft Condensed Matter, School of Materials and Energy,
Guangdong University of Technology, Guangzhou 510006, China.; Guangdong Provincial
Key Laboratory of Functional Soft Condensed Matter, School of Materials and Energy,
Guangdong University of Technology, Guangzhou 510006, China.; Institute of
Orthopaedics and Musculoskeletal Science, Division of Surgery and Interventional
Science, University College London, Royal National Orthopaedic Hospital, London HA4
4LP, UK.; Guangdong Provincial Key Laboratory of Functional Soft Condensed Matter,
School of Materials and Energy, Guangdong University of Technology, Guangzhou
510006, China.; Guangdong Provincial Key Laboratory of Functional Soft Condensed
Matter, School of Materials and Energy, Guangdong University of Technology,
Guangzhou 510006, China.; Institute of Orthopaedics and Musculoskeletal Science,
Division of Surgery and Interventional Science, University College London, Royal
National Orthopaedic Hospital, London HA4 4LP, UK.; Guangdong Provincial Key
Laboratory of Stomatology, Department of Operative Dentistry and Endodontics,
Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University,
Guangzhou 510275, China.
PY - 2023
ST - Hydrogels for Oral Tissue Engineering: Challenges and Opportunities
T2 - Molecules (Basel, Switzerland)
TI - Hydrogels for Oral Tissue Engineering: Challenges and Opportunities
VL - 28
Y2 - 5 y3 - 7
ID - 14192
ER -
TY - JOUR
AB - The thermoresponsive drug-loaded hydrogels have attracted widespread interest
in the field of medical applications due to their ease of delivery to structurally
complex tissue defects. However, drug-resistant infections remain a challenge,
which has prompted the development of new non-antibiotic hydrogels. To this end, we
prepared chitosan-methacrylate (CTSMA)/gelatin (GEL) thermoresponsive hydrogels and
added natural phenolic compounds, including tannic acid, gallic acid, and
pyrogallol, to improve the efficacy of hydrogels. This hybrid hydrogel imparted
initial crosslinking at physiological temperature, followed by photocuring to
further provide a mechanically robust structure. Rheological analysis, tensile
strength, antibacterial activity against E. coli, S. aureus, P. gingivalis, and S.
mutans, and L929 cytotoxicity were evaluated. The experimental results showed that
the hybrid hydrogel with CTSMA/GEL ratio of 5/1 and tannic acid additive had a
promising gelation temperature of about 37 °C. The presence of phenolic compounds
not only significantly (p < 0.05) enhanced cell viability, but also increased the
tensile strength of CTSMA/GEL hybrid hydrogels. Moreover, the hydrogel containing
tannic acid revealed potent antibacterial efficacy against four microorganisms. It
was concluded that the hybrid hydrogel containing tannic acid could be a potential
composite material for medical applications.
AN - rayyan-563559731
AU - Chen, C. C.
AU - Wang, J. M.
AU - Huang, Y. R.
AU - Yu, Y. H.
AU - Wu, T. M.
AU - Ding, S. J.
IS - 4
KW - calorimeter
camera
CLARIOstars
D8 SSS
DHR-2
EOS M6
Epoch
flowmeter
JSM-7800F
microplate reader
microwell plate
X-ray diffractometer
chitosan
gallic acid
gelatin
hydrogel
phenol derivative
polyphenol
tannin
article
cell viability
chemical structure
controlled study
cytotoxicity
energy dispersive X ray spectroscopy
Escherichia coli
field emission scanning electron microscopy
gelation
glass transition temperature
nonhuman
periodontitis
polymerization
surface property
synergistic effect
tensile strength
thermogravimetry
viscoelasticity
LA - English
PY - 2023
SN - 1999-4923
ST - Synergistic Effect of Thermoresponsive and Photocuring Methacrylated
Chitosan-Based Hybrid Hydrogels for Medical Applications
T2 - Pharmaceutics
TI - Synergistic Effect of Thermoresponsive and Photocuring Methacrylated
Chitosan-Based Hybrid Hydrogels for Medical Applications
VL - 15
ID - 13105
ER -
TY - JOUR
AB - Periodontitis is a chronic inflammatory oral disease that affects nearly 50%
of all adults. Fusobacterium nucleatum (F. nucleatum) is known to be involved in
the formation and development of periodontitis. Outer membrane vesicles (OMVs)
harboring toxic bacterial components are continuously released during F. nucleatum
growth and regulate the extent of the inflammatory response by controlling the
functions of immune and non-immune cells in tissues. Macrophages are important
immune cells in periodontal tissue that resist pathogen invasion and play an
important role in the pathophysiological process of periodontitis. However, the
role of the interaction between F. nucleatum OMVs and macrophages in the occurrence
and development of periodontitis has not been studied. The purpose of this study
was to clarify the effect of F. nucleatum OMVs on the polarization of macrophages
and the roles of this specific polarization and F. nucleatum OMVs in the
pathophysiology of periodontitis. The periodontitis model was established by
inducing ligation in C57BL/6 mice as previously described. Micro-CT, RT-qPCR,
hematoxylin-eosin (H&E) and tartrate acid phosphatase (TRAP) staining assays were
performed to analyze the periodontal tissue, alveolar bone loss, number of
osteoclasts and expression of inflammatory factors in gingival tissue. The changes
in the state and cytokine secretion of bone marrow-derived macrophages (BMDMs)
stimulated by F. nucleatum OMVs were observed in vivo by confocal microscopy, flow
cytometry, Western blot and ELISA. Mouse gingival fibroblasts (MGFs) were isolated
and then cocultured with macrophages. The effects of F. nucleatum OMVs on the
proliferation and apoptosis of MGFs were analyzed by flow cytometry and lactate
dehydrogenase (LDH) assays. The periodontitis symptoms of mice in the F. nucleatum
OMVs + ligation group were more serious than those of mice in the simple ligation
group, with more osteoclasts and more inflammatory factors (IL-1β, IL-6, and TNF-α)
being observed in their gingival tissues. M0 macrophages transformed into M1
macrophages after the stimulation of BMDMs with F. nucleatum OMVs, and the M1
macrophages then released more inflammatory cytokines. Analysis of the coculture
model showed that the MGF apoptosis and LDH release in the inflammatory environment
were increased by F. nucleatum OMV treatment. In conclusion, F. nucleatum OMVs were
shown to aggravate periodontitis, alveolar bone loss and the number of osteoclasts
in an animal model of periodontitis. F. nucleatum OMVs promoted the polarization of
macrophages toward the proinflammatory M1 phenotype, and the inflammatory
environment further aggravated the toxicity of F. nucleatum OMVs on MGFs. These
results suggest that M1 macrophages and F. nucleatum OMVs play roles in the
occurrence and development of periodontitis.
AN - rayyan-563559878
AU - Chen, G.
AU - Sun, Q.
AU - Cai, Q.
AU - Zhou, H.
DO - 10.3389/fmicb.2022.815638
KW - immunoglobulin test kit
ampicillin
beta actin
calvasculin
CD 206 antigen
CD11b antigen
CD163 antigen
CD86 antigen
cytokine
gentamicin
glycoprotein p 15095
interleukin 10
interleukin 1beta
interleukin 6
lactate dehydrogenase
metronidazole
outer membrane protein
synaptotagmin I
tartrate acid phosphatase
unclassified drug
vancomycin
vimentin
adult
alveolar bone
alveolar bone loss
animal cell
animal experiment
animal model
animal tissue
apoptosis
article
bacterium culture
bone density
cell proliferation
cell structure
colony forming unit
computer assisted tomography
confocal microscopy
controlled study
cytokine production
cytokine release
density gradient centrifugation
electrochemiluminescence
Escherichia coli
flow cytometry
fluorescence activated cell sorting
genotype phenotype correlation
gingival fibroblast
gingival tissue
immune response
immunofluorescence
immunofluorescence assay
immunoregulation
inflammation
innate immunity
lactate dehydrogenase release assay
Lactobacillus rhamnosus
ligation
M0 macrophage
M1 macrophage
macrophage
macrophage activation
male
mass spectrometry
membrane vesicle
micro-computed tomography
mouse gingival fibroblast
nanoparticle tracking analysis
nonhuman
osteoclast
osteoclastogenesis
outer membrane vesicle
pathogenicity
periodontal tissue
periodontitis
phagocytosis
plaque index
polarization
protein phosphorylation
quantitative study
RAW 264.7 cell line
RNA extraction
Streptococcus salivarius
Western blotting
LA - English
PY - 2022
SN - 1664-302X
ST - Outer Membrane Vesicles From Fusobacterium nucleatum Switch M0-Like
Macrophages Toward the M1 Phenotype to Destroy Periodontal Tissues in Mice
TI - Outer Membrane Vesicles From Fusobacterium nucleatum Switch M0-Like
Macrophages Toward the M1 Phenotype to Destroy Periodontal Tissues in Mice
VL - 13
ID - 13252
ER -
TY - JOUR
AB - This study developed a drug-loadable hydrogel system with high plasticity and
favorable biological properties to enhance oral bone tissue regeneration. Hydrogels
of different calcium alginate concentrations were prepared. Their swelling ratio,
degradation time, and bovine serum albumin (BSA) release rate were measured. Human
periodontal ligament cells (hPDLCs) and bone marrow stromal cells (BMSCs) were
cultured with both calcium alginate hydrogels and polylactic acid (PLA), and then
we examined the proliferation of cells. Inflammatory-related factor gene
expressions of hPDLCs and osteogenesis-related gene expressions of BMSCs were
observed. Materials were implanted into the subcutaneous tissue of rabbits to
determine the biosecurity properties of the materials. The materials were also
implanted in mandibular bone defects and then scanned using micro-CT. The calcium
alginate hydrogels caused less inflammation than the PLA. The number of mineralized
nodules and the expression of osteoblast-related genes were significantly higher in
the hydrogel group compared with the control group. When the materials were
implanted in subcutaneous tissue, materials showed favorable biocompatibility. The
calcium alginate hydrogels had superior osteoinductive bone ability to the PLA. The
drug-loadable calcium alginate hydrogel system is a potential bone defect
reparation material for clinical dental application.
AN - rayyan-563560298
AU - Chen, L.
AU - Shen, R.
AU - Komasa, S.
AU - Xue, Y.
AU - Jin, B.
AU - Hou, Y.
AU - Okazaki, J.
AU - Gao, J.
DO - 10.3390/ijms18050989
IS - 5
KW - alizarin red s
calcium alginate
interleukin 1beta
interleukin 6
interleukin 8
keratin
osteopontin
osteoprotegerin
polylactic acid
vimentin
animal experiment
animal model
animal tissue
article
biocompatibility
bone defect
bone densitometry
bone marrow stroma cell
bone mineralization
bone tissue
cell migration
cell proliferation
controlled study
cytotoxicity
drug bone level
gene expression
histology
human
human cell
hydrogel
inflammation
jaw malformation
male
New Zealand rabbit
nonhuman
periodontics
swelling
tissue regeneration
tissue repair
LA - English
PY - 2017
SN - ["1422-0067", "1661-6596"]
ST - Drug-loadable calcium alginate hydrogel system for use in oral bone tissue
repair
TI - Drug-loadable calcium alginate hydrogel system for use in oral bone tissue
repair
VL - 18
ID - 13672
ER -
TY - JOUR
AB - Oral diseases are a prevalent global health problem that are primarily
characterized by microbial infections, inflammation, and destruction of oral
tissues. Maintaining good oral health is essential for a high quality of life, but
the effective treatment of oral diseases and the regeneration of lost dental
tissues remain challenging. Hydrogels have emerged as promising biomaterials in
modern dental medicine. Their 3D network structures, high water content, good
biocompatibility, and various bioactivities enable them to serve as drug delivery
platforms, antimicrobial materials, tissue regeneration scaffolds, and biosensors.
This review provides an overview of the formation mechanisms, structures, and
functions of hydrogels, and highlights their latest applications in treating oral
and maxillofacial diseases, such as periodontal diseases, caries, pulp diseases,
oral cancer, and mucosal diseases.
AN - rayyan-563562554
AU - Chen, W. E.
AU - Zhang, C. F.
AU - Peng, S. M.
AU - Lin, Y. F.
AU - Ye, Z.
DO - 10.1002/adtp.202300128
PY - 2023
SN - 2366-3987
ST - Hydrogels in Dental Medicine
T2 - ADVANCED THERAPEUTICS
TI - Hydrogels in Dental Medicine
Y2 - 7 y3 - 10
ID - 15928
ER -
TY - JOUR
AB - It is found that the activation of Sonic Hedgehog (SHH) signaling pathway is
related to the degree of inflammation in patients suffering from periodontitis.
Cullin3 (CUL3), an important ubiquitin ligase, can control SHH signaling. In this
study, we were dedicated to clarify the roles of SHH and CUL3 in P. gingivalis-LPS
(Pg-LPS)-treated periodontal ligament stem cells (PDLSCs). In this study, cell
viability was detected using cell counting kit-8 (CCK-8). The inflammatory
cytokines of PDLSCs were estimated by enzyme-linked immunosorbent assay (ELISA).
With the application of western blots, the protein levels of SHH, Gli1 and NF-E2-
related factor 2 (Nrf2) were determined. Alkaline phosphatase staining and Alizarin
red staining were performed to evaluate the differentiation and mineralization
capabilities of PDLSCs. The apoptotic cells were screened using TUNEL staining. The
results showed that Pg-LPS inhibited cell viability and triggered inflammation of
PDLSCs. Overexpression of CUL3 weakened the differentiation and mineralization
capabilities of PDLSCs. Moreover, CUL3 overexpression aggravated inflammation and
cell apoptosis induced by Pg-LPS. It is worth noting that although the protein
levels of SHH, Gli1 and Nrf2 were elevated in PDLSCs treated with Pg-LPS,
overexpression of CUL3 decreased the expressions of Gli1 and Nrf2. Overall,
SHH/Gli1 and Nrf2 were involved in the inflammation and cell apoptosis of PDLSCs,
which was dominated by CUL3.
AN - rayyan-563560041
AU - Chen, W.
AU - Su, J.
AU - Cai, S.
AU - Shi, C.
DO - 10.1080/21655979.2021.1943603
IS - 1
KW - cell viability assay kit
chemiluminescence analyzer
diagnostic kit
ELISA kit
microscope
protein detection kit
TUNEL staining kit
alizarin red s
cullin
cullin 3
interleukin 10
interleukin 1beta
interleukin 6
kelch like ECH associated protein 1
lipopolysaccharide
sonic hedgehog protein
transcription factor Gli1
transcription factor Nrf2
unclassified drug
apoptosis
article
cell counting
cell viability
controlled study
down regulation
gene overexpression
human
human cell
inflammation
Nrf2 signaling
periodontitis
plasmid
signal transduction
stem cell
TUNEL assay
ubiquitination
Western blotting
cell counting kit-8
LA - English
PY - 2021
SN - ["2165-5987", "2165-5979"]
SP - 3089-3100
ST - Cullin3 aggravates the inflammatory response of periodontal ligament stem
cells via regulation of SHH signaling and Nrf2
T2 - Bioengineered
TI - Cullin3 aggravates the inflammatory response of periodontal ligament stem
cells via regulation of SHH signaling and Nrf2
VL - 12
ID - 13415
ER -
TY - JOUR
AB - Oral diseases are a prevalent global health problem that are primarily
characterized by microbial infections, inflammation, and destruction of oral
tissues. Maintaining good oral health is essential for a high quality of life, but
the effective treatment of oral diseases and the regeneration of lost dental
tissues remain challenging. Hydrogels have emerged as promising biomaterials in
modern dental medicine. Their 3D network structures, high water content, good
biocompatibility, and various bioactivities enable them to serve as drug delivery
platforms, antimicrobial materials, tissue regeneration scaffolds, and biosensors.
This review provides an overview of the formation mechanisms, structures, and
functions of hydrogels, and highlights their latest applications in treating oral
and maxillofacial diseases, such as periodontal diseases, caries, pulp diseases,
oral cancer, and mucosal diseases.
AN - rayyan-563559777
AU - Chen, W.
AU - Zhang, C.
AU - Peng, S.
AU - Lin, Y.
AU - Ye, Z.
DO - 10.1002/adtp.202300128
KW - biocompatibility
biological activity
biosensor
dental caries
dentistry
destruction
global health
health
infectious inflammation
maxillofacial disorder
mouth cancer
mouth disease
mouth tissue
mucosal disease
periodontal disease
quality of life
review
surgery
tissue regeneration
tooth tissue
water content
antiinfective agent
hydrogel
LA - English
PY - 2023
SN - 2366-3987
ST - Hydrogels in Dental Medicine
T2 - Adv. Ther.
TI - Hydrogels in Dental Medicine
ID - 13151
ER -
TY - JOUR
AB - Periodontitis is a chronic inflammatory disease characterized by the
colonization of pathogenic microorganisms and the loss of periodontal supporting
tissue. However, the existing local drug delivery system for periodontitis has some
problems including subpar antibacterial impact, easy loss, and unsatisfactory
periodontal regeneration. In this study, a multi-functional and sustained release
drug delivery system (MB/BG@LG) was developed by encapsulating methylene blue (MB)
and bioactive glass (BG) into the lipid gel (LG) precursor by Macrosol technology.
The properties of MB/BG@LG were characterized using a scanning electron microscope,
a dynamic shear rotation rheometer, and a release curve. The results showed that
MB/BG@LG could not only sustained release for 16 days, but also quickly fill the
irregular bone defect caused by periodontitis through in situ hydration. Under 660
nm light irradiation, methylene blue-produced reactive oxygen species (ROS) can
reduce local inflammatory response by inhibiting bacterial growth. In addition, in
vitro and vivo experiments have shown that MB/BG@LG can effectively promote
periodontal tissue regeneration by reducing inflammatory response, promoting cell
proliferation and osteogenic differentiation. In summary, MB/BG@LG exhibited
excellent adhesion properties, self-assembly properties, and superior drug release
control capabilities, which improved the clinical feasibility of its application in
complex oral environments.
AN - rayyan-563562018
AU - Chen, Y. K.
AU - Dai, F.
AU - Deng, T.
AU - Wang, L. J.
AU - Yang, Y. T.
AU - He, C. J.
AU - Liu, Q. D.
AU - Wu, J. X.
AU - Ai, F. R.
AU - Song, L.
DO - 10.1016/j.mtbio.2023.100699
PY - 2023
SN - 2590-0064
ST - An injectable MB/BG@LG sustained release lipid gel with antibacterial and
osteogenic properties for efficient treatment of chronic periodontitis in rats
T2 - MATERIALS TODAY BIO
TI - An injectable MB/BG@LG sustained release lipid gel with antibacterial and
VL - 21
Y2 - 8
ID - 15392
ER -
TY - JOUR
AB - Arg-gingipain B (RgpB), a major virulence factor secreted by the periodontal
pathogen Porphyromonas gingivalis is an Arg-specific cysteine proteinase. By
monitoring proteolytic cleavage of a human salivary peptide histatin 5 using MALDI-
TOF MS, RgpB purified from P. gingivalis HG66 was found to shift from a dominant
Arg-X to dominant Lys-X activity, both in vitro and in vivo, upon reversible
cysteine oxidation. Native PAGE analysis revealed the association of novel Lys-X
activity with a reversible state change of the oxidized enzyme. The redox-regulated
Lys-X activity of RgpB may provide a survival advantage to P. gingivalis against
the oxidative host defence. © 2013 Federation of European Biochemical Societies.
Published by Elsevier B.V. All rights reserved.
AN - rayyan-563560484
AU - Chen, Y. Y.
AU - Seers, C. A.
AU - Slakeski, N.
AU - Moore, C.
AU - Zhang, L.
AU - Reynolds, E. C.
DO - 10.1016/j.febslet.2013.02.051
IS - 9
KW - arginine gingipain B
bacterial protein
cysteine proteinase
histatin 5
lysine
unclassified drug
amino acid substitution
article
bacterial secretion system
bacterial survival
bacterial virulence
controlled study
host resistance
human
in vitro study
in vivo study
nonhuman
oxidation reduction reaction
priority journal
protein cleavage
protein secretion
LA - English
PY - 2013
SN - ["0014-5793", "1873-3468"]
SP - 1275-1280
ST - Reversible redox regulation of specificity of Arg-gingipain B in
T2 - FEBS Lett.
TI - Reversible redox regulation of specificity of Arg-gingipain B in
VL - 587
ID - 13858
ER -
TY - JOUR
AB - Periodontitis is a chronic inflammatory disease characterized by the
colonization of pathogenic microorganisms and the loss of periodontal supporting
tissue. However, the existing local drug delivery system for periodontitis has some
problems including subpar antibacterial impact, easy loss, and unsatisfactory
periodontal regeneration. In this study, a multi-functional and sustained release
drug delivery system (MB/BG@LG) was developed by encapsulating methylene blue (MB)
and bioactive glass (BG) into the lipid gel (LG) precursor by Macrosol technology.
The properties of MB/BG@LG were characterized using a scanning electron microscope,
a dynamic shear rotation rheometer, and a release curve. The results showed that
MB/BG@LG could not only sustained release for 16 days, but also quickly fill the
irregular bone defect caused by periodontitis through in situ hydration. Under 660
nm light irradiation, methylene blue-produced reactive oxygen species (ROS) can
reduce local inflammatory response by inhibiting bacterial growth. In addition, in
vitro and vivo experiments have shown that MB/BG@LG can effectively promote
periodontal tissue regeneration by reducing inflammatory response, promoting cell
proliferation and osteogenic differentiation. In summary, MB/BG@LG exhibited
excellent adhesion properties, self-assembly properties, and superior drug release
control capabilities, which improved the clinical feasibility of its application in
complex oral environments.
AN - rayyan-563560827
AU - Chen, Y.
AU - Dai, F.
AU - Deng, T.
AU - Wang, L.
AU - Yang, Y.
AU - He, C.
AU - Liu, Q.
AU - Wu, J.
AU - Ai, F.
AU - Song, L.
DO - 10.1016/j.mtbio.2023.100699
J2 - Mater Today Bio
LA - eng
N1 - Center of Stomatology, The Second Affiliated Hospital of Nanchang University,
Nanchang, Jiangxi, 33006, China.; The Institute of Periodontal Disease, Nanchang
University, Nanchang, Jiangxi, 33006, China.; JXHC Key Laboratory of Periodontology
(The Second Affiliated Hospital of Nanchang University), Nanchang, Jiangxi, 33006,
China.; The Second Clinical Medical School, Nanchang University, Nanchang, Jiangxi,
33006, China.; Center of Stomatology, The Second Affiliated Hospital of Nanchang
University, Nanchang, Jiangxi, 33006, China.; The Institute of Periodontal Disease,
Nanchang University, Nanchang, Jiangxi, 33006, China.; JXHC Key Laboratory of
Periodontology (The Second Affiliated Hospital of Nanchang University), Nanchang,
Jiangxi, 33006, China.; Center of Stomatology, The Second Affiliated Hospital of
Nanchang University, Nanchang, Jiangxi, 33006, China.; The Institute of Periodontal
Disease, Nanchang University, Nanchang, Jiangxi, 33006, China.; JXHC Key Laboratory
of Periodontology (The Second Affiliated Hospital of Nanchang University),
Nanchang, Jiangxi, 33006, China.; Center of Stomatology, The Second Affiliated
Hospital of Nanchang University, Nanchang, Jiangxi, 33006, China.; The Institute of
Periodontal Disease, Nanchang University, Nanchang, Jiangxi, 33006, China.; JXHC
Key Laboratory of Periodontology (The Second Affiliated Hospital of Nanchang
University), Nanchang, Jiangxi, 33006, China.; The Second Clinical Medical School,
Nanchang University, Nanchang, Jiangxi, 33006, China.; Center of Stomatology, The
Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 33006,
China.; The Institute of Periodontal Disease, Nanchang University, Nanchang,
Jiangxi, 33006, China.; JXHC Key Laboratory of Periodontology (The Second
Affiliated Hospital of Nanchang University), Nanchang, Jiangxi, 33006, China.; The
Second Clinical Medical School, Nanchang University, Nanchang, Jiangxi, 33006,
China.; Center of Stomatology, The Second Affiliated Hospital of Nanchang
Jiangxi, 33006, China.; The Second Clinical Medical School, Nanchang University,
Nanchang, Jiangxi, 33006, China.; Center of Stomatology, The Second Affiliated
Hospital of Nanchang University, Nanchang, Jiangxi, 33006, China.; The Institute of
Periodontal Disease, Nanchang University, Nanchang, Jiangxi, 33006, China.; JXHC
Key Laboratory of Periodontology (The Second Affiliated Hospital of Nanchang
University), Nanchang, Jiangxi, 33006, China.; The Second Clinical Medical School,
Nanchang University, Nanchang, Jiangxi, 33006, China.; Center of Stomatology, The
Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 33006,
China.; The Institute of Periodontal Disease, Nanchang University, Nanchang,
Jiangxi, 33006, China.; JXHC Key Laboratory of Periodontology (The Second
Affiliated Hospital of Nanchang University), Nanchang, Jiangxi, 33006, China.;
School of Advanced Manufacturing, Nanchang University, Nanchang, Jiangxi, 33006,
China.; Center of Stomatology, The Second Affiliated Hospital of Nanchang
Jiangxi, 33006, China.
PY - 2023
SP - 100699
ST - An injectable MB/BG@LG sustained release lipid gel with antibacterial and
T2 - Materials today. Bio
TI - An injectable MB/BG@LG sustained release lipid gel with antibacterial and
VL - 21
Y2 - 8
ID - 14201
ER -
TY - JOUR
AB - Multiple-pathogen periodontal disease necessitates a local release and
concentration of antibacterial medication to control inflammation in a particular
location of the mouth cavity. Therefore, it is necessary to effectively load and
deliver medicine/antibiotics to treat numerous complex bacterial infections. This
study developed chlorhexidine (CHX)/polycaprolactone (PCL) nanofiber membranes with
controlled release properties as periodontal dressings to prevent or treat oral
disorders. Electrostatic spinning was adopted to endow the nanofiber membranes with
a high porosity, hydrophilicity, and CHX loading capability. The release of CHX
occurred in a concentration-dependent manner. The CHX/PCL nanofiber membranes
exhibited good biocompatibility with human periodontal ligament stem cells, with
cell viability over 85% in each group via CCK-8 assay and LIVE/DEAD staining;
moreover, the good attachment of the membrane was illustrated by scanning electron
microscopy imaging. Through the agar diffusion assay, the nanofiber membranes with
only 0.075 wt% CHX exhibited high antibacterial activity against three typical oral
infection-causing bacteria: Porphyromonas gingivalis, Enterococcus faecalis, and
Prevotella intermedia. The results indicated that the CHX/PCL nanofiber holds great
potential as a periodontal dressing for the prevention and treatment periodontal
disorders associated with bacteria.
AN - rayyan-563562483
AU - Chen, Z. J.
AU - Lv, J. C.
AU - Wang, Z. G.
AU - Wang, F. Y.
AU - Huang, R. H.
AU - Zheng, Z. L.
AU - Xu, J. Z.
AU - Wang, J.
DO - 10.3390/jfb13040280
IS - 4
PY - 2022
SN - 2079-4983
ST - Polycaprolactone Electrospun Nanofiber Membrane with Sustained Chlorohexidine
Release Capability against Oral Pathogens
T2 - JOURNAL OF FUNCTIONAL BIOMATERIALS
TI - Polycaprolactone Electrospun Nanofiber Membrane with Sustained Chlorohexidine
Release Capability against Oral Pathogens
VL - 13
Y2 - 12
ID - 15857
ER -
TY - JOUR
AB - OBJECTIVE: To compare the clinical effect of Ginkgo biloba extract gel
(Ginkgo biloba extract,EGB) and minocycline hydrochloride (Periocline) on
periodontitis and their inhibition on putative periodontal pathogens. METHODS:
Thirty patients with moderate-to-severe periodontitis were selected. The patients
were divided into an experimental group and a positive control group (minocycline
hydrochloride). Supragingival and subgingival scaling were performed on all
patients. Subgingival plaque samples were collected before treatment, 1 week, 2
months and 4 months after treatment. The four major periodontal pathogens
Porphyromonas gingivalis (Pg), Bacteroides forsythus (Bf), Prevotella intermedia
(Pi), Treponema denticola (Td) were detected by polymerase chain reaction. Clinical
indexes plaque index (PLI), bleeding index (BI) and probing depth (PD), attachment
loss (AL) were examined before treatment, 3 months and 6 months after treatment.
The results were statistically analyzed. RESULTS: The detection rates of the 4
periodontal pathogens were Td (83.3%), Tf (95.0%), Pi (80.0%), Pg (81.7% ) in
experimental group and Td (83.3%), Tf (95.0%), Pi (80.0%), Pg (81.7%) in control
group before treatment. The detection rates in experimental group were not
significantly different with those in control group after treatment, except for the
detection rate of Pg 1 week after treatment (P < 0.01, the detection of Pg was
56.7% in experimental group and 53.3% in control group 1 week after treatment). The
PLI and BI were not significantly different between experimental group and control
group after treatment (P > 0.05). The difference was statistically significant at 6
months after treatment [(3.5 ± 0.5) mm for experimental group and (3.2 ± 0.4) mm
for control group, P = 0.00]. The mean of AL decreased with time. The difference
was statistically significant at 6 months after treatment [ (4.5 ± 0.4) mm for
experimental group and (4.3 ± 0.4) mm for control group at 6 months, P = 0.01].
CONCLUSIONS: The inhibition effects of EGB and minocycline hydrochloride were
comparable for major periodontal pathogens within short term.
AN - rayyan-563560423
AU - Cheng, Q.
AU - Gao, W.
AU - Cao, B.
AU - Liu, Y.
AU - Zeng, Z.
AU - Wang, Z.
IS - 6
minocycline
comparative study
Ginkgo biloba
human
microbiology
periodontal pocket
periodontics
periodontitis
tooth plaque
Treponema denticola
LA - Chinese
PY - 2014
SN - 1002-0098
SP - 347-351
ST - Comparison of the effects of Ginkgo biloba extract and minocycline
hydrochlovide on periodontitis
T2 - Zhonghua Kou Qiang Yi Xue Za Zhi
TI - Comparison of the effects of Ginkgo biloba extract and minocycline
hydrochlovide on periodontitis
VL - 49
ID - 13797
ER -
TY - JOUR
AB - Background: Subjects with Down syndrome (DS) experience a high prevalence of
periodontal disease, and the management of this disease in subjects with DS is a
challenge for oral health care providers. The purpose of this case series was to
follow the periodontal healing response changes over a 12-month period after non-
surgical mechanical periodontal therapy with the adjunctive use of chlorhexidine
and monthly recalb in adults with DS who presented initially with chronic
periodontitis. Methods: Twenty-one subjects with DS (14 males and seven females;
25.3 ± 5.5 years of age) with reported mild-to-moderate learning disabilities and
chronic periodontitis were recruited and treated by non-surgical mechanical
periodontal therapy (followed by monthly recalls) and the adjunctive use of
chlorhexidine gel for toothbrushing and chlorhexidine mouthwash twice daily.
Clinical data were recorded. Results: After 12 months of non-surgical mechanical
periodontal therapy, the mean percentage of sites with plaque decreased from 84.1%
to 23.6%, and the mean number of sites with bleeding on probing decreased from
82.1% to 29.5%. Mean probing depth decreased from 3.2 to 1.8 mm, with a mean
clinical attachment level gain of 0.6 mm. Conclusions: Satisfactory healing
responses were achieved following non-surgical mechanical periodontal therapy with
the adjunctive use of chlorhexidine and monthly recalls in adults with DS with
chronic periodontitis and mild-to-moderate learning disabilities. Such a treatment
regimen seems appropriate and beneficial for adults with DS and chronic
periodontitis.
AN - rayyan-563560724
AU - Cheng, R. H. W.
AU - Leung, W. K.
AU - Corbet, E. F.
DO - 10.1902/jop.2008.070247
IS - 2
KW - chlorhexidine
toothpaste
adult
article
dental procedure
Down syndrome
female
gel
human
male
mouthwash
periodontitis
prospective study
tooth plaque
LA - English
PY - 2008
SN - 0022-3492
SP - 379-385
ST - Non-surgical periodontal therapy with adjunctive chlorhexidine use in adults
with down syndrome: A prospective case series
TI - Non-surgical periodontal therapy with adjunctive chlorhexidine use in adults
with down syndrome: A prospective case series
VL - 79
ID - 14098
ER -
TY - JOUR
AB - Glycyrrhiza glabra (GG) elicits protective effects against periodontal
diseases. However, the sustained bioavailability of GG extract at therapeutic
concentration warrants ideal delivery vehicles. Present study has focused on the
design, fabrication, and evaluations of ethanolic-crude extract of GG-loaded semi-
interpenetrating network (semi-IPN) hydrogel (HAAPS-GG) using alginic acid and
polyvinyl alcohol (PVA) hydrogel mosaicked with HA for periodontal regeneration.
The study has examined the performance of the hydrogel against the selected oral
pathogens S. mutans, E. faecalis, L. acidophilus and C. albicans. HAAPS-GG was
successfully fabricated and the surface functional groups were confirmed by
attenuated total reflectance-infrared (ATR-IR) spectroscopy. HAAPS-GG displayed
interconnecting pores, hydrophilicity and excellent water profile contributing to
the biocompatibility as evident from direct contact and MTT assay in L929
fibroblasts. The hydrogel was mechanically stable and was immunocompatible owing to
the relatively decreased levels of pro-inflammatory mediators COX2, 5LPO, iNOS and
MPO in RAW 264.7 macrophages. In addition, the transcript analysis on RAW 264.7
revealed the down-regulation of inflammatory transcription factor NF-κβ and the
pro-inflammatory cytokine TNF-α. Importantly, HAAPS-GG arrested the progression of
periodontal pathogens predominantly S. mutans, and C. albicans as evident by disc
diffusion assay, MTT assay and confocal microscopy. Overall, the HAAPS-GG system
offers promising translational avenues in periodontal regeneration.
AN - rayyan-563559786
AU - Chenicheri, S.
AU - Ramachandran, R.
AU - Rajamanikam, U.
DO - 10.1007/s40204-022-00199-2
IS - 4
KW - confocal microscope
cyclooxygenase 2
Glycyrrhiza glabra extract
hydrogel
hydroxyapatite
myeloperoxidase
polyvinyl alcohol
article
bacterial growth
biocompatibility
Candida albicans
cell culture
cell infiltration
confocal microscopy
disk diffusion
down regulation
infectious agent
Lactobacillus acidophilus
MTT assay
nonhuman
particle size
periodontal disease
zeta potential
zone of inhibition
LA - English
PY - 2022
SN - ["2194-0517", "2194-0509"]
SP - 373-383
ST - Antimicrobial effects of hydroxyapatite mosaicked polyvinyl alcohol-alginate
semi-interpenetrating hydrogel-loaded with ethanolic extract of Glycyrrhiza glabra
against oral pathogens
T2 - Prog. Biomater.
TI - Antimicrobial effects of hydroxyapatite mosaicked polyvinyl alcohol-alginate
semi-interpenetrating hydrogel-loaded with ethanolic extract of Glycyrrhiza glabra
against oral pathogens
VL - 11
ID - 13160
ER -
TY - JOUR
AB - OBJECTIVES: The periodontal pathogen Porphyromonas gingivalis produces
hydrogen sulfide (H2S). H2S in the oral cavity is positively correlated with
periodontitis but the mechanism by which H2S contributes to periodontal diseases is
obscure. We investigated the effect of H2S in combination with P. gingivalis
lipopolysaccharide (LPS) on expression of the pro-inflammatory cytokines
interleukin (IL)-6 and IL-8 in periodontal fibroblasts and the underlying mechanism
of action. MATERIAL AND METHODS: Gingival fibroblasts (GFs) and periodontal
ligament cells (PDLCs) were treated with different concentrations of the H2S donor
NaHS in the presence/absence of P. gingivalis LPS for different time periods.
Expression of IL-6 and IL-8 was detected by real-time PCR and ELISA. The activity
of nuclear factor-kappa B (NF-κB) signalling was investigated using western
blotting, EMSA and pathway blockade assays. RESULTS: Real-time PCR and ELISA
results showed that H2S not only upregulated expression of IL-6 and IL-8 at mRNA
and protein levels in a dose- and time-dependent manner, but also aggravated P.
gingivalis LPS-induced expression of IL-6 and IL-8 in GFs and PDLCs. Western
blotting and EMSA showed that NF-κB signalling was activated by NaHS, P. gingivalis
LPS, and both, which was in accordance with the expression levels of IL-6 and IL-8
in GFs and PDLCs. These results were confirmed using a NF-κB pathway blockade
assay. CONCLUSIONS: H2S synergistically upregulated P. gingivalis LPS-induced
expression of IL-6 and IL-8 in GFs and PDLCs via activation of NF-κB signalling,
which could promote the development of periodontitis.
AN - rayyan-563560420
AU - Chi, X. P.
AU - Ouyang, X. Y.
AU - Wang, Y. X.
DO - 10.1016/j.archoralbio.2014.05.022
IS - 9
KW - hydrogen sulfide
interleukin 6
interleukin 8
lipopolysaccharide
cytology
drug effect
fibroblast
human
metabolism
signal transduction
upregulation
Western blotting
LA - English
PY - 2014
SN - 1879-1506
SP - 954-961
ST - Hydrogen sulfide synergistically upregulates Porphyromonas gingivalis
lipopolysaccharide-induced expression of IL-6 and IL-8 via NF-κB signalling in
periodontal fibroblasts
TI - Hydrogen sulfide synergistically upregulates Porphyromonas gingivalis
lipopolysaccharide-induced expression of IL-6 and IL-8 via NF-κB signalling in
VL - 59
ID - 13794
ER -
TY - JOUR
AB - Objective: The aim of the present study was to assess two vehicles and forms
of the in-home administration of chlorhexidine for the control of dental biofilm in
children with special needs. Basic Research Design: Twenty-nine children aged seven
to 12 years (mixed dentition phase) participated in the study. A double-blind,
placebo-controlled, cross-over clinical trial was carried out with the following
treatment groups: 1- 0.12% chlorhexidine gel (CG); 2- placebo gel (PG); 3- 0.12%
chlorhexidine spray (CS); 4- placebo spray (PS). Ten-day experiment periods were
separated by 15-day washout intervals. Main Outcome Measures: The parameters
evaluated were plaque, gingival bleeding, and preferences of parents/caregivers.
Results: The initial conditions were similar in each phase of the experiment
(p>0.05). The treatments with chlorhexidine (gel and spray) achieved a significant
reduction (p<0.0001) in plaque and bleeding. The placebo treatments did not achieve
significant differences (p>0.05). The parents/caregivers preferred the
administration of chlorhexidine in spray form. Conclusions: The topical
administration of chlorhexidine associated to tooth brushing led to a reduction in
dental biofilm and gingival bleeding in children with special needs. Administration
in spray form proved easier and was preferred by parents/caregivers. © BASCD 2011.
AN - rayyan-563560576
AU - Chibinski, A. C. R.
AU - Pochapski, M. T.
AU - Farago, P. V.
AU - Santos, F. A.
AU - Czlusniak, G. D.
DO - 10.1922/CDH_2593Santos05
IS - 3
KW - chlorhexidine
article
child
clinical trial
controlled study
crossover procedure
dental procedure
female
gel
gingivitis
human
male
methodology
nonparametric test
oral spray
patient preference
periodontics
tooth plaque
LA - English
PY - 2011
SN - 0265-539X
SP - 222-226
ST - Clinical evaluation of chlorhexidine for the control of dental biofilm in
children with special needs
T2 - Community Dent. Health
TI - Clinical evaluation of chlorhexidine for the control of dental biofilm in
children with special needs
VL - 28
ID - 13950
ER -
TY - JOUR
AB - Tannerella forsythia is strongly implicated in the development of
periodontitis, an inflammatory disease that destroys the bone and soft tissues
supporting the tooth. To date, the knowledge of the virulence attributes of T.
forsythia species has mainly come from studies with a laboratory adapted strain
(ATCC 43037). In this study, we focused on two T. forsythia clinical isolates, UB4
and UB20, in relation to their ability to activate macrophages. We found that these
clinical isolates differentially induced proinflammatory cytokine expression in
macrophages. Prominently, the expression of the chemokine protein IP-10 (CXCL10)
was highly induced by UB20 as compared to UB4 and the laboratory strain ATCC 43037.
Our study focused on the lipopolysaccharide component (LPS) of these strains and
found that UB20 expressed a smooth-type LPS, unlike UB4 and ATCC 43037 each of
which expressed a rough-type LPS. The LPS from UB20, via activation of TLR4, was
found to be a highly potent inducer of IP-10 expression via signaling through STAT1
(signal transducer and activator of transcription-1). These data suggest that
pathogenicity of T. forsythia species could be strain dependent and the LPS
heterogeneity associated with the clinical strains might be responsible for their
pathogenic potential and severity of periodontitis.
AN - rayyan-563559920
AU - Chinthamani, S.
AU - Settem, R. P.
AU - Honma, K.
AU - Stafford, G. P.
AU - Sharma, A.
DO - 10.1093/femspd/ftac008
IS - 1
KW - culture medium
ELISA kit
PCR assay kit
sample lysis equipment
serum-free medium
amphotericin
buffer
colony stimulating factor 1
complementary DNA
cysteine
cytokine
deoxycholate sodium
deoxyribonuclease
deoxyribonuclease I
dextran
distilled water
endonuclease
gamma interferon inducible protein 10
hemin
interferon regulatory factor 7
interleukin 10
interleukin 1beta
interleukin 6
lipopolysaccharide
menadione
oligosaccharide
phorbol 13 acetate 12 myristate
phosphatase
polysorbate 20
proteinase
proteinase K
recombinant protein
ribonuclease A
STAT1 protein
streptomycin
SYBR green
triton x 100
trometamol
antigen presenting cell
article
bacterial cell
bacterial strain
bacterium isolate
cell culture
cell death
cell lysate
cell suspension
controlled study
cytokine release
cytolysis
data analysis
dimerization
electrophoresis
extraction
fetal bovine serum
gene expression
gene expression level
genetic heterogeneity
housekeeping gene
immunoblotting
macrophage
monocyte
mononuclear cell
nonhuman
phosphorylation
protein analysis
protein expression
purification
real time reverse transcription polymerase chain reaction
reverse transcription
RNA isolation
room temperature
secretion (process)
silver staining
supernatant
THP-1 cell line
tissue culture
virulence
Western blotting
whole cell
LA - English
PY - 2022
SN - 2049-632X
ST - Tannerella forsythia strains differentially induce interferon gamma-induced
protein 10 (IP-10) expression in macrophages due to lipopolysaccharide
heterogeneity
T2 - Pathog. Dis.
TI - Tannerella forsythia strains differentially induce interferon gamma-induced
protein 10 (IP-10) expression in macrophages due to lipopolysaccharide
heterogeneity
VL - 80
ID - 13294
ER -
TY - JOUR
AB - Background: The inflammatory disease periodontitis results in tooth loss and
can even lead to diseases of the whole body if not treated. Gingival crevicular
fluid (GCF) reflects the condition of the gingiva and contains proteins transuded
from serum or cells at inflamed sites. In this study, we aimed to discover
potential protein biomarkers for periodontitis in GCF proteome using
LC-MS/MS.Results: We identified 305 proteins from GCF of healthy individuals and
periodontitis patients collected using a sterile gel loading tip by ESI-MS/MS
coupled to nano-LC. Among these proteins, about 45 proteins were differentially
expressed in the GCF proteome of moderate periodontitis patients when compared to
the healthy individuals. We first identified azurocidin in the GCF, but not the
saliva, as an upregulated protein in the periodontitis patients and verified its
increased expression during periodontitis by ELISA using the GCF of the classified
periodontitis patients compared to the healthy individuals. In addition, we found
that azurocidin inhibited the differentiation of bone marrow-derived macrophages to
osteoclasts.Conclusions: Our results show that GCF collection using a gel loading
tip and subsequent LC-MS/MS analysis following 1D-PAGE proteomic separation are
effective for the analysis of the GCF proteome. Our current results also suggest
that azurocidin could be a potential biomarker candidate for the early detection of
inflammatory periodontal destruction by gingivitis and some chronic periodontitis.
Our data also suggest that azurocidin may have an inhibitory role in osteoclast
differentiation and, thus, a protective role in alveolar bone loss during the early
stages of periodontitis. © 2011 Choi et al; licensee BioMed Central Ltd.
AN - rayyan-563560581
AU - Choi, Y. H.
AU - Heo, S. H.
AU - Lee, J. M.
AU - Cho, J. Y.
DO - 10.1186/1477-5956-9-42
KW - azurocidin
calgranulin B
catalase
cystatin B
cytokeratin 2
gelatinase B
glycerophosphoinositol inositolphosphodiesterase
hemoglobin beta chain
leukocyte elastase
myeloblastin
nucleoside diphosphate kinase B
phosphotransferase
secretory component
stefin A
thymidine phosphorylase
unclassified drug
animal cell
article
controlled study
disease marker
gingivitis
human
macrophage
mass spectrometry
mouse
nonhuman
osteoclast
periodontitis
protein analysis
protein expression
proteomics
upregulation
LA - English
PY - 2011
SN - 1477-5956
ST - Identification of azurocidin as a potential periodontitis biomarker by a
proteomic analysis of gingival crevicular fluid
T2 - Proteome Sci.
TI - Identification of azurocidin as a potential periodontitis biomarker by a
proteomic analysis of gingival crevicular fluid
VL - 9
ID - 13955
ER -
TY - JOUR
AN - rayyan-563562129
AU - Choo, A.
AU - Delac, D. M.
AU - Messer, L. B.
DO - 10.1111/j.1834-7819.2001.tb00277.x
IS - 3
PY - 2001
SP - 166-173
ST - Oral hygiene measures and promotion: Review and considerations
T2 - Australian Dental Journal
TI - Oral hygiene measures and promotion: Review and considerations
0035463564&doi=10.1111%2fj.1834-
7819.2001.tb00277.x&partnerID=40&md5=ad0226cda8f0c0925cf06ca4c4f83c76
VL - 46
ID - 15503
ER -
TY - JOUR
AB - Aim: R-spondin 4 (RSPO4) is a suggestive risk gene of stage III–IV, grade C
periodontitis and upregulated in gingiva of mice resistant to bacteria-induced
alveolar bone loss. We aimed to replicate the association, identify and
characterize the putative causal variant(s) and molecular effects, and understand
the downstream effects of RSPO4 upregulation. Materials and Methods: We performed a
two-step association study for RSPO4 with imputed genotypes of a German–Dutch (896
stage III–IV, grade C periodontitis cases, 7104 controls) and Spanish sample (441
cases and 1141 controls). We analysed the allelic effects on transcription factor
binding sites with reporter gene and antibody electrophoretic mobility shift
assays. We used CRISPR/dCas9 activation and RNA sequencing to pinpoint RSPO4 as the
target gene and to analyse downstream effects. Results: RSPO4 was associated with
periodontitis (rs6056178, pmeta = 4.6 × 10−5). rs6056178 contains a GATA-binding
motif. The rs6056178 T-allele abolished reporter activity (p =.004) and reduced
GATA binding (−14.5%). CRISPRa of the associated region increased RSPO4 expression
(25.8 ± 6.5-fold, p =.003). RSPO4 activation showed strongest induction of
Gliomedin (439-fold) and Mucin 21 (178-fold) and of the gene set “response to
interferon-alpha” (area under the curve [AUC] = 0.8, p < 5 × 10−6). The most
repressed gene set was “extracellular matrix interactions” (AUC = 0.8, padj
=.00016). Conclusion: RSPO4 is a potential periodontitis risk gene and modifies
host defence and barrier integrity.
AN - rayyan-563559723
AU - Chopra, A.
AU - Song, J.
AU - Weiner, J.
AU - Keceli, H. G.
AU - Dincer, P. R.
AU - Cruz, R.
AU - Carracedo, A.
AU - Blanco, J.
AU - Dommisch, H.
AU - Schaefer, A. S.
DO - 10.1111/jcpe.13758
IS - 4
KW - alpha interferon
gliomedin
glycoprotein
mucin
R-spondin 4
transcription factor GATA
unclassified drug
alveolar bone loss
article
bioinformatics
case control study
cell culture
chromatin immunoprecipitation sequencing
controlled study
CRISPR-CAS9 system
DNA sequence
down regulation
gene activation
gene expression
gene frequency
gene set enrichment analysis
genetic association
genetic transcription
genotype
haplotype
human
human cell
human tissue
innate immunity
luciferase assay
oral barrier integrity
periodontitis
permeability barrier
reporter gene
RNA sequencing
single nucleotide polymorphism
staging
thrombocyte activation
upregulation
LA - English
PY - 2023
SN - ["1600-051X", "0303-6979"]
SP - 476-486
ST - RSPO4 is a potential risk gene of stages III–IV, grade C periodontitis
through effects on innate immune response and oral barrier integrity
TI - RSPO4 is a potential risk gene of stages III–IV, grade C periodontitis
through effects on innate immune response and oral barrier integrity
VL - 50
ID - 13097
ER -
TY - JOUR
AB - Platelet concentrates have emerged as innovative autologous blood products
that enhance tissue healing and regeneration in regenerative therapy. A common
feature of these products is their higher than baseline platelet concentration,
which improves wound healing and tissue repair. Four main categories of products
can be easily defined, based on their leukocyte content and fibrin architecture:
pure platelet-rich plasma, such as Cell Separator PRP or Anitua' PRGF; leukocyte-
and platelet-rich plasma (L-PRP), such as PCCS or Ace PRP; pure platelet-rich
fibrin (P-PRF), such as Fibrinet PRFM; and leukocyte- and platelet-rich fibrin (L-
PRF), such as Choukroun's PRF. Two families contain significant concentrations of
leukocytes: L-PRP and L-PRF. These four families of products have different
biological signatures and mechanisms and obviously different clinical applications.
An L-PRF membrane releases growth factors and matrix proteins over a period longer
than 7 days, whereas a PRP gel matrix releases and disperses its growth factors in
a relatively quick download. In the near future, simple and inexpensive products
such as L-PRF are expected to have applications in oral-maxillofacial surgery,
periodontal surgery, plastic surgery, orthopedic surgery, and sports medicine.
Leukocytes substantially affect the intrinsic biology and properties of platelet
concentrates, not only because they enhance immune function and antibacterial
potential, but also because they have essential roles in the wound healing process.
Unfortunately, their impact has been almost completely neglected in the literature.
Improved understanding of the effects of leukocytes in wound healing is essential
for development of new clinical applications of platelet concentrates.
AN - rayyan-563560123
AU - Chou, T. M.
AU - Chang, H. P.
AU - Wang, J. C.
DO - 10.1002/kjm2.12192
IS - 5
KW - growth factor
leukocyte platelet rich fibrin
matrix protein
platelet-rich fibrin
pure platelet rich fibrin
thrombocyte concentrate
unclassified drug
human
leukocyte
leukocyte platelet rich plasma
maxillofacial surgery
oral surgery
review
LA - English
PY - 2020
SN - ["2410-8650", "1607-551X"]
SP - 305-310
ST - Autologous platelet concentrates in maxillofacial regenerative therapy
T2 - Kaohsiung J. Med. Sci.
TI - Autologous platelet concentrates in maxillofacial regenerative therapy
VL - 36
ID - 13497
ER -
TY - JOUR
AB - A 46-kDa hemolytic protein, referred to as cystalysin, from Treponema
denticola ATCC 35404 was overexpressed in Escherichia coli LC-67. Both the native
and recombinant 46-kDa proteins were purified to homogeneity. Both proteins
expressed identical biological and functional characteristics. In addition to its
biological function of lysing erythrocytes and hemoxidizing the hemoglobin to
methemoglobin, cystalsin was also capable of removing the sulfhydryl and amino
groups from selected S-containing compound (e.g., cysteine) producing H2S, NH3, and
pyruvate. This cysteine desulfhydrase resulted in the following Michaelis-Menten
kinetics: K(m) = 3.6 mM and k(cat) = 12 s-1. Cystathionine and S-aminoethyl-L-
cysteine were also substrates for the protein. Gas chromatography-mass spectrometry
and high-performance liquid chromatography analysis of the end products revealed
NH3, pyruvate, homocysteine (from cystathionine), and cysteamine (from S-
aminoethyl-L- cysteine). The enzyme was active over a broad pH range, with highest
activity at pH 7.8 to 8.0. The enzymatic activity was increased by β-
mercaptoethanol. It was not inhibited by the proteinase inhibitor TLCK (Nα-p-tosyl-
L-lysine chloromethyl ketone), pronase, or proteinase K, suggesting that the
functional site was physically protected or located in a small fragment of the
polypeptide. We hypothesize that cystalysin is a pyridoxal-5-phosphate- containing
enzyme, with activity of an αC-N and βC-S lyase (cystathionase) type. Since large
amounts of H2S have been reported in deep periodontal pockets, cystalysin may also
function in vivo as an important virulence molecule.
AN - rayyan-563561051
AU - Chu, L.
AU - Ebersole, J. L.
AU - Kurzban, G. P.
AU - Holt, S. C.
DO - 10.1128/iai.65.8.3231-3238.1997
IS - 8
KW - ammonia
bacterial enzyme
cystalysin
cystathionine
cystathionine gamma lyase
hemoglobin
homocysteine
mercaptamine
mercaptoethanol
methemoglobin
pronase
proteinase K
pyruvic acid
tosyllysyl chloromethyl ketone
unclassified drug
amino acid composition
article
bacterial virulence
controlled study
enzyme activity
enzyme kinetics
enzyme substrate
hemolysis
immunoblotting
nonhuman
periodontal disease
pH
priority journal
Treponema denticola
LA - English
PY - 1997
SN - 0019-9567
SP - 3231-3238
ST - Cystalysin, a 46-kilodalton cysteine desulfhydrase from Treponema denticola,
with hemolytic and hemoxidative activities
T2 - INFECT. IMMUN.
TI - Cystalysin, a 46-kilodalton cysteine desulfhydrase from Treponema denticola,
with hemolytic and hemoxidative activities
VL - 65
ID - 14425
ER -
TY - JOUR
AB - Periodontal immunomorphology was found changed during an inflammation, these
changes presenting as fixation of immune complexes with IgA and IgG in the
periodontal tissues. The intensity of the immunopathologic reaction corresponded to
the severity of periodontal inflammation, correlated with clinical evaluation of
periodontal status and capillary stability level reduced under the effect of
treatment, and was effectively arrested by pentoxil directly in the periodontal
focus of inflammation. Due to its immunoregulating effect on periodontal tissues
and antibacterial action pentoxil application as a component of carbohydrate gel
prolonging its action helped attain favorable and stable results in periodontitis
treatment.
AN - rayyan-563561084
AU - Chuchmai, G. S.
AU - Shirikhanova Yu, I.
IS - 4
KW - immunoglobulin A
immunoglobulin G
pentoxyl
article
human
immunohistology
immunoregulation
inflammation
periodontitis
LA - Russian
PY - 1993
SN - 0039-1735
SP - 12-15
ST - Therapy of periodontal inflammations with long-acting pentoxil
T2 - STOMATOLOGIYA
TI - Therapy of periodontal inflammations with long-acting pentoxil
VL - 72
ID - 14458
ER -
TY - COMP
AB - Periodontal immunomorphology was found changed during an inflammation, these
changes presenting as fixation of immune complexes with IgA and IgG in the
periodontal tissues. The intensity of the immunopathologic reaction corresponded to
the severity of periodontal inflammation, correlated with clinical evaluation of
periodontal status and capillary stability level reduced under the effect of
treatment, and was effectively arrested by pentoxil directly in the periodontal
focus of inflammation. Due to its immunoregulating effect on periodontal tissues
and antibacterial action pentoxil application as a component of carbohydrate gel
prolonging its action helped attain favorable and stable results in periodontitis
treatment.
AN - rayyan-563561458
AU - Chuchmaĭ, G. S.
AU - Shirikhanova, IIu
CY - Russia (Federation)
ET - 4
J2 - Stomatologiia (Mosk)
KW - Adjuvants, Immunologic/*therapeutic use
Adult
Biopharmaceutics
Drug Evaluation
Female
Fluorescent Antibody Technique
Humans
Male
Pentoxyl/pharmacokinetics/*therapeutic use
Periodontitis/*drug therapy/immunology/pathology
Periodontium/drug effects/immunology/pathology
LA - rus
PY - 1993
SN - 0039-1735 (Print)
SP - 12-5
ST - [The treatment of inflammatory periodontal diseases using prolonged-action
pentoxyl]
T2 - Stomatologiia
TI - [The treatment of inflammatory periodontal diseases using prolonged-action
pentoxyl]
VL - 72
Y2 - 10
ID - 14832
ER -
TY - JOUR
AB - At present, in situ-forming microparticles (ISM) containing antibiotic drugs
are an alternative formulation for the treatment of periodontitis. In this study,
Eudragit® RS PO (ERS) was incorporated in the internal phase of ISM as the matrix-
forming agent using dimethyl sulfoxide (DMSO) or 2-pyrrolidone (PYR) as a solvent.
Doxycycline hyclate (DH) was chosen as the drug model against periodontal
pathogens. Olive oil and camellia oil were used as the external oil phases. The DH-
loaded ISM formula presented advantages in terms of injectability over the in situ-
forming gel (ISG) owing to the lubricant effect of the outer oil phase and lower
viscosity compared with ERS-based ISGs. ISMs containing these two oils exhibited
high injectability, suitable phase transformation, and prolonged drug release for 7
days. The obtained microparticles were spherical with a porous structure. Moreover,
ISM exhibited effectiveness against periodontal pathogens, which was appropriate
for development into local drug delivery to treat periodontitis.
AN - rayyan-563559859
AU - Chuenbarn, T.
AU - Chantadee, T.
AU - Phaechamud, T.
DO - 10.1016/j.jddst.2022.103294
KW - 2 pyrrolidinone
beta cyclodextrin
dimethyl sulfoxide
doxycycline hyclate
eudragit
lubricating agent
olive oil
animal experiment
animal tissue
article
Camellia
chemical structure
comparative study
controlled study
drug solubility
emulsion
Escherichia coli
gingivitis
human
in vitro study
injection
nonhuman
periodontitis
pH
physical appearance
porosity
topography
viscosity
zone of inhibition
LA - English
PY - 2022
SN - 1773-2247
ST - Doxycycline hyclate-loaded Eudragit® RS PO in situ-forming microparticles for
periodontitis treatment
TI - Doxycycline hyclate-loaded Eudragit® RS PO in situ-forming microparticles for
VL - 71
ID - 13233
ER -
TY - JOUR
AB - Vancomycin hydrochloride (HCl) is a glycopeptide antibiotic used to treat
serious or life-threatening infections, and it reduces plaque scores and gingivitis
in periodontal patients. In this study, vancomycin HCl was incorporated into rosin
in situ forming gel (ISG) and rosin in situ forming microparticles (ISM) to
generate a local drug delivery system to treat periodontal disease. The physical
properties of the ISG and ISM were measured, including pH, viscosity,
injectability, adhesion properties, in-vitro transformation, and drug release.
Moreover, the effectiveness of antimicrobial activity was tested using the agar-cup
diffusion method against Staphylococcus aureus, Streptococcus mutans, Porphyromonas
gingivalis, and Escherichia coli. Vancomycin HCl-loaded rosin-based ISG and ISM had
a pH value in the range of 5.02−6.48 and exhibited the ease of injection with an
injection force of less than 20 N. Additionally, the lubricity effect of the
external oil phase of ISM promoted less work of injection than ISG and 40−60%
rosin-based ISM showed good emulsion stability. The droplet size of emulsions
containing 40%, 50%, and 60% rosin was 98.48 ± 16.11, 125.55 ± 4.75, and 137.80 ±
16.8 µm, respectively. Their obtained microparticles were significantly smaller in
diameter, 78.63 ± 12.97, 93.81 ± 10.53, and 118.32 ± 15.61 µm, respectively,
because the particles shrank due to the solvent loss from solvent exchange.
Moreover, increasing the concentration of rosin increased the size of
microparticles. After phase transformation, all formulations had better plasticity
properties than elasticity; therefore, they could easily adapt to the specific
shape of a patient’s gum cavity. Both developed ISG and ISM presented inhibition
zones against S. mutans and P. gingivalis, with ISG presenting significantly more
effectively against these two microbes (p < 0.05). The vancomycin HCl-loaded rosin
ISG and ISM delayed drug release for 7 days with efficient antimicrobial
activities; thus, they exhibit potential as the drug delivery systems for
periodontitis treatment.
AN - rayyan-563560829
AU - Chuenbarn, T.
AU - Sirirak, J.
AU - Tuntarawongsa, S.
AU - Okonogi, S.
AU - Phaechamud, T.
DO - 10.3390/gels8040231
IS - 4
J2 - Gels
LA - eng
N1 - Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn
University, Nakhon Pathom 73000, Thailand.; Department of Chemistry, Faculty of
Science, Silpakorn University, Nakhon Pathom 73000, Thailand.; Pharmaceutical
Intellectual Center "Prachote Plengwittaya", Faculty of Pharmacy, Silpakorn
University, Nakhon Pathom 73000, Thailand.; Natural Bioactive and Material for
Health Promotion and Drug Delivery System Group (NBM), Faculty of Pharmacy,
Silpakorn University, Nakhon Pathom 73000, Thailand.; Research Center of
Pharmaceutical Nanotechnology, Faculty of Pharmacy, Chiang Mai University, Chiang
Mai 50200, Thailand.; Department of Pharmaceutical Sciences, Faculty of Pharmacy,
Chiang Mai University, Chiang Mai 50200, Thailand.; Department of Pharmaceutical
Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000,
Thailand.; Pharmaceutical Intellectual Center "Prachote Plengwittaya", Faculty of
Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.
PY - 2022
ST - Design and Comparative Evaluation of Vancomycin HCl-Loaded Rosin-Based In
Situ Forming Gel and Microparticles
T2 - Gels (Basel, Switzerland)
TI - Design and Comparative Evaluation of Vancomycin HCl-Loaded Rosin-Based In
Situ Forming Gel and Microparticles
VL - 8
Y2 - 4 y3 - 8
ID - 14203
ER -
TY - CPAPER
AB - In-situ forming micro-particle (ISM) is an emulsion system that could change
into micro-particulate matrices by phase separation of matrix former. In this
research work, bleach shellac (BS) was used as the matrix forming agent to develop
the doxycycline hyclate (DH)-loaded ISM and the different oils were used as the
external phase of non-aqueous in oil emulsion. ISMs were prepared by using BS
dissolved in dimethyl sulfoxide (DMSO), N-methyl pyrrolidone (NMP), or 2-
pyrrolidone (PYR) as the internal phase and the external phase containing glycerol
monosterate (GMS) in various oils including camellia oil, canola oil, olive oil,
safflower oil, and sesame oil. The physical properties of ISMs using PYR as the
solvent of the internal phase were tested including viscosity, in vitro micro-
particle formation, injectability, drug release, surface topography, and
antibacterial activity against Porphyrommonas gingivalis. All DH-loaded ISMs were
easy to be injected through a needle and formed into micro-particles after exposure
to phosphate buffer. The external oil phase reduced the friction between barrel and
plunger of syringe and thus promoting easier injectability. The particular drug-
loaded ISM prepared from safflower oil was largest, while that prepared from sesame
oil was smallest and that of the others had no significant difference (p < 0.05).
After 60 sec, the particle size of drug-loaded formula had no presence of
coalescence. DH released from BS ISM was sustainable longer than 50 days. Sponge
topography of micro-particle after DH release test in SEM micrographs confirmed the
solvent exchange initiated further phase separation of BS into a micro-particular
sponge. They efficient inhibited against P. gingivalis with a sustainable drug
release character from the retardation of drug diffusion. Thus, DH-loaded ISMs
using PYR as the solvent of the internal phase could be fabricated with various
oils and exhibited the potential use for periodontitis treatment. (c) 2021 Elsevier
Ltd. All rights reserved. Selection and peer-review under responsibility of the
scientific committee of the 5th International Conference on Smart Materials and
Nanotechnology.
AN - rayyan-563562415
AU - Chuenbarn, T.
AU - Janmahasatian, S.
AU - Phaechamud, T.
DO - 10.1016/j.matpr.2021.03.549
PY - 2021
SP - 3546-3553
TI - Bleached shellac in situ forming micro-particle fabricated with different
oils as antibacterial delivery system for periodontitis treatment
VL - 47
ID - 15789
ER -
TY - JOUR
AB - Currently, the available methods of treating parodontitis are not able to
have a complex effect. Therefore, in recent years, there has been an active search
and development of new methods of treatment and new drugs that have a complex
etiopathogenetic effect on this disease. This article provides a comparative
evaluation of the classical and experimental methods of treating chronic
periodontitis. Based on the reconstruction of an experimental model of chronic
inflammation of periodontal tissues of the Wistar rat line, we compared methods of
topical therapy by “Organosilicon Glycerohydrogel – Peptide” and “Polyoxidonium”
compositions. A comparative assessment of the activity of these drugs with control
groups, which were treated with “Organosilicon Glycerohydrogel” and “Metrogyl
Denta”, was carried out. Previously, we carried out separate studies of the
effectiveness of the use of the composition “organosilicon glycerohydrogel –
peptide”, as well as the method of treatment of periodontitis, by injecting the
drug “Polyoxidonium”. They have been compared with the classic treatment for this
disease to obtain relevant data and results. In our opinion, the data obtained are
of considerable interest. The assessment and comparison of clinical and
histological data have been carried out, which showed that all drugs had a positive
effect on the processes of tissue regeneration. However, the composition
“Organosilicon Glycerohydrogel-peptide”, due to the characteristics of the
hydrogel, which is acting as a transcutaneous conductor, showed a faster
antimicrobial and pathogenetic effect, which allows a comprehensive approach to
solving this problem. In comparison with the groups of “Organosilicon
Glycerohydrogel” and “Polyoxidonium”, the period of clinical improvement increased
by 57% in the group of “Glycerohydrogel-Peptide”, and, in the “Metrogyl Denta”
group, the indicators improved by 15% approximately.
AN - rayyan-563559781
AU - Chumakov, N. S.
AU - Khlystova, K. A.
AU - Sarkisyan, N. G.
AU - Mamedov, M. M.
DO - 10.15789/1563-0625-CEO-2785
IS - 4
KW - animal experiment
animal model
article
conductor
controlled study
histopathology
human
male
nonhuman
periodontitis
periodontium
rat
tissue regeneration
topical treatment
Wistar rat
antiinfective agent
azoximer bromide
endogenous compound
hydrogel
metronidazole
organosilicon derivative
silicon
LA - English
PY - 2023
SN - ["2313-741X", "1563-0625"]
SP - 851-854
ST - COMPARATIVE EVALUATION OF THE EFFECTIVENESS OF A PEPTIDE-CONTAINING DRUG AND
POLYOXYDONIUM IN THE TREATMENT OF CHRONIC PARODONTITIS
T2 - СРАВНИТЕЛЬНАЯ ОЦЕНКА ЭФФЕКТИВНОСТИ ПЕПТИДСОДЕРЖАЩЕГО ПРЕПАРАТА И
ПОЛИОКСИДОНИЯ В ЛЕЧЕНИИ ХРОНИЧЕСКОГО ПАРОДОНТИТА
TI - COMPARATIVE EVALUATION OF THE EFFECTIVENESS OF A PEPTIDE-CONTAINING DRUG AND
POLYOXYDONIUM IN THE TREATMENT OF CHRONIC PARODONTITIS
VL - 25
ID - 13155
ER -
TY - JOUR
AB - Objective: To test the antiadherent and antibacterial properties of surface
modification of orthodontic wires with photocatalytic titanium oxide (TiO 2).
Materials and Methods: TiO2 was coated on the surface of the orthodontic wires by a
sol-gel thin film dip-coating method. Bacterial adhesion to the wires was evaluated
by the weight change of the wires. The antibacterial activity of the surface-
modified orthodontic wires was demonstrated by the dilution agar plate method for
Streptococcus mutans and spectrophotometry for Porphyromonas gingivalis. Results:
The orthodontic wires coated with the photocatalytic TiO2 showed an antiadherent
effect against S. mutans compared with the uncoated wires. The bacterial mass that
bound to the TiO2-coated orthodontic wires remained unchanged, whereas that of the
uncoated wires increased by 4.97%. Furthermore, the TiO 2-coated orthodontic wires
had a bactericidal effect on S. mutans and P. gingivalis, which cause dental caries
and periodontitis, respectively. The antiadherent and antibacterial mechanisms of
TiO2 to break down the cell wall of those bacteria were revealed by scanning
electron microscopy. Conclusion: The surface modification of orthodontic wires with
photocatalytic TiO2 can be used to prevent the development of dental plaque during
orthodontic treatment. © 2007 by The EH Angle Education and Research Foundation,
Inc.
AN - rayyan-563560747
AU - Chun, M. J.
AU - Shim, E.
AU - Kho, E. H.
AU - Park, K. J.
AU - Jung, J.
AU - Kim, J. M.
AU - Kim, B.
AU - Lee, K. H.
AU - Cho, D. L.
AU - Bai, D. H.
AU - Lee, S. I.
AU - Hwang, H. S.
AU - Ohk, S. H.
DO - 10.2319/0003-3219(2007)077[0483:SMOOWW]2.0.CO;2
IS - 3
biomaterial
titanium
titanium dioxide
article
bacterium adherence
drug effect
orthodontic device
physiology
surface property
LA - English
PY - 2007
SN - ["0003-3219", "0003-3219"]
SP - 483-488
ST - Surface modification of orthodontic wires with photocatalytic titanium oxide
for its antiadherent and antibacterial properties
T2 - Angle Orthod.
TI - Surface modification of orthodontic wires with photocatalytic titanium oxide
for its antiadherent and antibacterial properties
VL - 77
ID - 14121
ER -
TY - JOUR
AB - Background: Prolonged gingivitis may lead to periodontitis, with permanent
damage to tooth-supporting tissues. Goal of this pilot study was to determine
whether Optical Coherence Tomography (OCT) imaging can be used as a convenient
alternative to laborious clinical indices to track changes in gingival and
periodontal health. Study: In this randomized, controlled, double-blind pilot study
(UCI IRB 2002-2805), 10 subjects with periodontitis were recruited. 5 subjects
received a novel dentifrice, Livionex Dental Gel, and the other 5, Colgate Total
toothpaste. After initial clinical examination, plaque, gingival, periodontal
indices, and full pocket charting were documented by a clinician. After OCT and
intraoral images, volunteers received standardized oral hygiene instructions.
Patient oral hygiene and indices listed above were documented at weekly intervals
for 6 weeks. Periodontal pocket charting was determined at beginning and end of the
study. From OCT images, changes in soft and hard supporting tissues of the teeth
were measured using a software-based point-to-point measurement capability. Changes
in periodontal health over time based on clinical measurements were used as the
standard for evaluating images of the periodontium. Results: Plaque and gingival
index were the earliest indicators of changes in gingival inflammation. Reduced
redness and swelling of the gingiva were visible in the intra-oral camera images
and a reduction of 10-20% in gingival soft tissue swelling was apparent in OCT
images after 1 week, and continued progressively to end of the study; rate and
amount of change varied considerably between subjects and dentifrice used. Overall,
more durable plaque and gingivitis reduction was observed using Livionex gel
(p<0.05). Conclusion: Improved periodontal health resulting from better oral
hygiene can be mapped efficiently using OCT. Funding: grant RO3 EB014852 and
P41EB015890 from the National Institute of Biomedical Engineering; Livionex Inc Los
Gatos.
AN - rayyan-563560495
AU - Chung, N. E.
AU - Dadkhah, M.
AU - Sarraf, A.
AU - Kohanchi, D.
AU - Chan, G.
AU - Jow, B.
AU - Ajdaharian, J.
AU - Wink, C.
AU - Wilder-Smith, P.
DO - 10.1002/lsm.22127
KW - toothpaste
society
laser
surgery
imaging
mouth hygiene
health
gingivitis
tissues
tooth
human
periodontitis
pilot study
patient
volunteer
periodontics
funding
soft tissue
camera
gingiva
swelling
periodontium
software
edema
periodontal pocket
optical coherence tomography
LA - English
PY - 2013
SN - 0196-8092
SP - 66-67
ST - An imaging-based approach to evaluating dentifrice
TI - An imaging-based approach to evaluating dentifrice
VL - 45
ID - 13869
ER -
TY - JOUR
AB - BACKGROUND: Bacteroides forsythus, Porphyromonas gingivalis and Prevotella
intermedia are Gram-negative anaerobic bacteria that are currently considered
potential periopathogens. Prevotella nigrescens has recently been separated from P.
intermedia and its rôle in periodontitis is unknown. The erm(F) gene codes for an
rRNA methylase, conferring resistance to macrolides, lincosamides and streptogramin
B (MLSB), and the tet(Q) gene for a ribosomal protection protein, conferring
resistance to tetracycline. The presence of these resistance genes could impair the
use of antibiotics for therapy. PURPOSE: The aim of this study was to determine the
carriage of erm(F) and tet(Q), and genetic variability of 12 Porphyromonas
gingivalis, 10 Prevotella intermedia, 25 Prevotella nigrescens and 17 Bacteroides
forsythus isolates from 9 different patient samples. METHODS: We used polymerase
chain reaction (PCR) for detecting antibiotic resistance genes, and pulsed-field
gel electrophoresis (PFGE) for detecting genetic variability among the isolates.
RESULTS: Thirty-one (48%) isolates were resistant to both erythromycin and
tetracycline and carried the erm(F) and tet(Q) genes, eight (13%) were tetracycline
resistant and carried the tet(Q) gene, 9 (14%) were erythromycin resistant and
carried the erm(F) gene, and 12 (19%) isolates did not carry antibiotic resistance
genes. PFGE was used to compare isolates from the same patient and isolates from
different patient samples digested with XbaI. No association was found between
antibiotic resistance gene carriage and PFGE patterns in any species examined. All
isolates of the same species from the same patient had highly related or identical
PFGE patterns. Isolates of same species from different patients had unique PFGE
pattern for each species tested. CONCLUSION: All isolates of the same species from
any one patient were genetically related to each other but distinct from isolates
from other patients, and 66% of the patients carried antibiotic resistant isolates,
which could impair antibiotic therapy.
AN - rayyan-563560915
AU - Chung, W. O.
AU - Gabany, J.
AU - Persson, G. R.
AU - Roberts, M. C.
IS - 2
KW - adhesin
antiinfective agent
bacterial protein
ErmF protein, Bacteroides
erythromycin
methyltransferase
rRNA (adenosine O 2' )methyltransferase
rRNA (adenosine-O-2'-)methyltransferase
transcription factor
article
Bacteroides
chromosome map
comparative study
genetic variability
genetics
genotype
gingivitis
human
microbiology
periodontitis
phenotype
Prevotella
LA - English
PY - 2002
SN - 0303-6979
SP - 152-158
ST - Distribution of erm(F) and tet(Q) genes in 4 oral bacterial species and
genotypic variation between resistant and susceptible isolates
TI - Distribution of erm(F) and tet(Q) genes in 4 oral bacterial species and
genotypic variation between resistant and susceptible isolates
VL - 29
ID - 14289
ER -
TY - JOUR
AB - This review summarizes research that has assessed the effectiveness of
various antimicrobial-containing dentifrices in preventing and/or reducing a number
of oral health problems facing our patients today. The results of these studies
indicate that, when compared with a conventional fluoride dentifrice, the
triclosan/copolymer/fluoride dentifrice is the one with the most evidence to
support its ability to deliver significant oral health benefits with no adverse
effects. The benefits maybe summarized as follows: improved levels ofsupragingival
plaque control; improved gingival health; reducedlikelihood of gingivitis
progressing to periodontitis; arrest progression of periodontitis; prevention of
supragingival calculus; and reduction in oral malodor. With increased interest in
the association of oral health with systemic health, this dentifrice is well-
positioned to help reduce the likelihood of gingivitis establishing itself and
possibly developing into periodontitis (Figure 1). It also has the potential to
have beneficial effects on general health because of its anti-inflammatory
properties. Based on the results presented in this article, it is clear that the
general population can derive significant clinical benefits from the daily use of a
triclosan/copolymer/fluoride dentifrice. The dental profession should feel
confident to recommend its use to patients to improve oral health and maintain or
promote overall health.
AN - rayyan-563560608
AU - Ciancio, S. G.
IS - 1
KW - chloride
silicic acid
tin fluoride
toothpaste
triclosan
zinc chloride
zinc derivative
dental caries
drug combination
human
periodontitis
review
tooth plaque
LA - English
PY - 2011
SN - 1548-8578
SP - 70-76
ST - Controlling biofilm with evidence-based dentifrices
T2 - Compend Contin Educ Dent
TI - Controlling biofilm with evidence-based dentifrices
VL - 32
ID - 13982
ER -
TY - JOUR
AN - rayyan-563560617
AU - Ciancio, S.
AU - Panagakos, F. S.
IS - 4
KW - sodium fluoride
silicic acid
toothpaste
triclosan
article
chemistry
drug combination
gingivitis
human
tooth plaque
LA - English
PY - 2010
SN - 0895-8831
SP - 93-95
ST - Superior management of plaque and gingivitis through the use of a
triclosan/copolymer dentifrice
T2 - J. Clin. Dent.
TI - Superior management of plaque and gingivitis through the use of a
triclosan/copolymer dentifrice
VL - 21
ID - 13991
ER -
TY - JOUR
AB - Hydrophilic ointment, Periodontal Nowadays, bacterial resistance to classical
drugs (antibiotics) is increasingly mentioned in the literature. The same situation
is presented in the case of bacteria in the oral cavity, so there is an acute need
to formulate new preparations with antibacterial or even anti-inflammatory or
antioxidant action. The need for these innovative preparations has increased the
attention on plant compounds. Thus, this paper brings to the fore hydrogel-type
formulations that are strongly compatible with the oral mucosa and contain active
substances with antibacterial, anti-inflammatory and antioxidant properties such as
magnolol and carvacrol. The hydrogel was designed in four types of formulas that
differ in the type of active substance but also in the added polymer concentration.
The gels formed were characterized from an organoleptic point of view, stability
and rheological properties. The analysis showed that the gels obtained conform to
the known standards and have a different viscosity due to the polymer added in
different concentrations (0.5% and 1%). Thus, in the future perspective, we want to
highlight the influence of the hydrogel base in the release of the active substance
respectively to test in vivo the antibacterial, anti-inflammatory and antioxidant
activity of the designed oral hydrogel. Copyright (C) 2013 - All Rights Reserved -
Pharmacophore
AN - rayyan-563562275
AU - Cicalau, G. I. P.
AU - Miere, F.
AU - Mandal, A. K.
AU - Ganea, M.
AU - Scrobota, I.
AU - Ciavoi, G.
AU - Jurca, C. M.
DO - 10.51847/A7vNt1HX00
IS - 2
PY - 2022
SN - 2229-5402
SP - 26-32
ST - FORMULATION AND CHARACTERIZATION OF HYDROPHILIC OINTMENT BASES WITH CARVACROL
AND MAGNOLOL FOR PERIODONTAL APPLICATION
T2 - PHARMACOPHORE
TI - FORMULATION AND CHARACTERIZATION OF HYDROPHILIC OINTMENT BASES WITH CARVACROL
AND MAGNOLOL FOR PERIODONTAL APPLICATION
VL - 13
ID - 15649
ER -
TY - JOUR
AB - The aim of this paper is to continue previous studies of gel formulation
containing metronidazole and having mucoadhesive properties for the treatment of
periodontal diseases by assessing their in vitro and in vivo characteristics. We
started from the premise that the crosslink density and swelling capacity of the
polyacrylic acid derivatives greatly affect the swelled mucoadhesive polymer which
penetrates into the tissue crevices followed by the interpenetration between the
polymer chains and protein chains of the mucus aimed to achieve correlations
between the rheological properties of gels and mucoadhesivity. The results showed
that the analysed gels F3_3, F3_1 (Ultrez 10) and F2_3 (Carbopol® 974P) have the
most appropriate rheological properties. To evaluate the kinetics of drug release
from the analysed gels, 9 kinetic models (functions of time) were performed.
R2adjusted (the adjusted coefficient of determination), MSC (model selection
criterion) and AIC criterion (Akaike informational criterion) used as goodness of
fit parameters indicated that Korsmeyer-Peppas is the most appropriate model to
describe the release kinetics of the drug release from the 9 gel formulations.
Preliminary clinical studies have shown that the topical application of
metronidazole gel formulations, in combination with mechanical treatment of
smoothening of the root surface appears to be more efficient, improving clinical
parameters. Plaque index (PI), bleeding on probing index (BOP), and probing pocket
depth (PPD) evaluated at one month post-treatment had better values compared with
those of the initial examination values in a greater number of the periodontal
examined sites (PI-54.15%, BOP-62.38%, and PPD- 28.45%) in the group B of patients
receiving scaling and root planning (SRP) and 15% metronidazole gel formulation
F3_3.
AN - rayyan-563560395
AU - Ciurba, A.
AU - Lazăr, L.
AU - Antonoaea, P.
AU - Georgescu, A. M.
AU - Vari, C. E.
AU - Todoran, N.
IS - 1
KW - carbomer
carbopol 940
carbopol 974p
carbopol ultrez 10
metronidazole
unclassified drug
article
clinical article
controlled study
drug formulation
drug release
flow kinetics
gel
gingiva bleeding
human
hydrogel
medical parameters
mucoadhesion
periodontal disease
tooth plaque
LA - English
PY - 2015
SN - 0014-8237
SP - 11-19
ST - In vitro/in vivo performance study of new metronidazole periodontal gel
formulations
T2 - Farmacia
TI - In vitro/in vivo performance study of new metronidazole periodontal gel
formulations
VL - 63
ID - 13769
ER -
TY - JOUR
AB - The clinical and microbiological effects of zinc ascorbate gel applied orally
in cats were evaluated during a 42-day study period. Cats were divided randomly
into two equal groups, with the treatment group (18 cats) receiving zinc ascorbate
gel and the control group (18 cats) receiving a placebo (0.9% sterile saline).
Clinical parameters evaluated biweekly included halitosis, plaque, calculus, and
gingivitis. Aerobic and anaerobic bacterial cultures were obtained from cats in the
treatment group at Days 0 and 42. There was a significant decrease in plaque,
gingivitis, and anaerobic periodontal pathogens in treatment group cats. Halitosis
and calculus scores were not significantly different in treatment group compared
with control group cats. The results of this study suggest that zinc ascorbate gel
used as an oral antiseptic improves feline oral health, and may be most effective
in decreasing bacterial growth, plaque formation, and gingivitis when applied
following a professional teeth cleaning procedure.
AN - rayyan-563560918
AU - Clarke, D. E.
IS - 4
KW - ascorbic acid
toothpaste
zinc derivative
animal
animal disease
article
cat
cat disease
clinical trial
controlled study
female
gel
gingivitis
halitosis
male
mouth hygiene
tooth plaque
treatment outcome
LA - English
PY - 2001
SN - 0898-7564
SP - 177-183
ST - Clinical and microbiological effects of oral zinc ascorbate gel in cats
T2 - J Vet Dent
TI - Clinical and microbiological effects of oral zinc ascorbate gel in cats
VL - 18
ID - 14292
ER -
TY - JOUR
AB - Prokaryotic secretion relies on proteins that are widely conserved, including
NTPases and secretins, and on proteins that are system specific. The Tad secretion
system in Aggregatibacter actinomycetemcomitans is dedicated to the assembly and
export of Flp pili, which are needed for tight adherence. Consistent with
predictions that RcpA forms the multimeric outer membrane secretion channel
(secretin) of the Flp pilus biogenesis apparatus, we observed the RcpA protein in
multimers that were stable in the presence of detergent and found that rcpA and its
closely related homologs form a novel and distinct subfamily within a well-
supported gene phylogeny of the entire secretin gene superfamily. We also found
that rcpA-like genes were always linked to Aggregatibacter rcpB- or Caulobacter
cpaD-like genes. Using antisera, we determined the localization and gross
abundances of conserved (RcpA and TadC) and unique (RcpB, RcpC, and TadD) Tad
proteins. The three Rcp proteins (RcpA, RcpB, and RcpC) and TadD, a putative
lipoprotein, localized to the bacterial outer membrane. RcpA, RcpC, and TadD were
also found in the inner membrane, while TadC localized exclusively to the inner
membrane. The RcpA secretin was necessary for wild-type abundances of RcpB and
RcpC, and TadC was required for normal levels of all three Rcp proteins. TadC
abundance defects were observed in rcpA and rcpC mutants. TadD production was
essential for wild-type RcpA and RcpB abundances, and RcpA did not multimerize or
localize to the outer membrane without the expression of TadD. These data indicate
that membrane proteins TadC and TadD may influence the assembly, transport, and/or
function of individual outer membrane Rcp proteins. Copyright © 2008, American
Society for Microbiology. All Rights Reserved.
AN - rayyan-563560723
AU - Clock, S. A.
AU - Planet, P. J.
AU - Perez, B. A.
AU - Figurski, D. H.
DO - 10.1128/JB.01347-07
IS - 3
KW - ampicillin
antibiotic agent
bacterial protein
chloramphenicol
Flp1 protein
kanamycin
nalidixic acid
RcpA protein
RcpB protein
RcpC protein
secretin
streptomycin
TadA protein
TadB protein
TadC protein
TadD protein
TadE protein
TadF protein
TadV protein
unclassified drug
amino acid sequence
article
bacterial gene
bacterial growth
bacterium adherence
bacterium pilus
flp 1 gene
gene locus
gene mutation
immunoblotting
nonhuman
nucleotide sequence
periodontitis
phylogeny
priority journal
rcpA gene
rcpB gene
rcpC gene
tadD gene
LA - English
PY - 2008
SN - 0021-9193
SP - 980-990
ST - Outer membrane components of the tad (tight adherence) secreton of
T2 - J. Bacteriol.
TI - Outer membrane components of the tad (tight adherence) secreton of
VL - 190
ID - 14097
ER -
TY - JOUR
AB - OBJECTIVE: To evaluate the clinical effects of a prescription tray
application of hydrogen peroxide gel as an adjunct to frequent maintenance
appointments for refractory periodontal patients. METHODS: Case series data were
analyzed from 66 failing periodontal maintenance patients who had exhausted
treatment options before using prescription trays with a 1.7% hydrogen peroxide gel
once or twice daily for two-and-a-half to five years. Data included pocket probing
depths (PPD), bleeding on probing (BOP), smoking status, and compliance with tray
usage. Data were collected prior to tray usage and after tray delivery at six
months, one year, and annual intervals. RESULTS: A clinical and statistical
reduction in BOP was maintained over the length of the study (p ≤ 0.01). No
differences were seen in patients who used trays two times or one time a day or in
patients who smoked or did not smoke. The 1.7% peroxide delivered via a
prescription tray was most effective in shallow pockets. Aggregate PPD distribution
did not change significantly. Of clinical relevance, only one tooth out of 1,745
teeth studied was lost due to periodontal disease during the study period.
CONCLUSION: Prescription tray application of peroxide gel, as an adjunct to
frequent periodontal maintenance appointments for refractory patients, demonstrated
significant reductions in BOP'for smokers and non-smokers who used tray delivery
once or twice a day.
AN - rayyan-563560406
AU - Cochrane, R. B.
AU - Sindelar, B.
IS - 4
gel
hydrogen peroxide
oxidizing agent
adult
aged
female
follow up
gingiva bleeding
human
male
middle aged
patient compliance
periodontal pocket
periodontics
procedures
smoking
surgery
surgical flaps
periodontal disease
treatment outcome
LA - English
PY - 2015
SN - 0895-8831
SP - 109-114
ST - Case Series Report of 66 Refractory Maintenance Patients Evaluating the
Effectiveness of Topical Oxidizing Agents
T2 - J Clin Dent
TI - Case Series Report of 66 Refractory Maintenance Patients Evaluating the
Effectiveness of Topical Oxidizing Agents
VL - 26
ID - 13780
ER -
TY - JOUR
AB - The purpose of this study was to compare the effects of a topical 5% vitamin
E gel, a placebo gel and chlorhexidine on established and developing plaque and
periodontal disease in 48 adult subjects. Baseline data included Plaque Index,
Gingival Index and periodontal probing depth. All data were collected by a single
calibrated examiner using a double-blind methodology. One group of subjects applied
12 mL of a vitamin E-containing gel delivering 800 mg of alpha-tocopherol, another
applied 12 mL of a placebo gel, and the final group rinsed with 0.5 oz of 0.12%
chlorhexidine gluconate. After two weeks, the clinical data were again recorded,
and two quadrants were randomly selected and treated by root planing and scaling,
with data collection repeated after both 4 and 6 weeks. Our results indicated that
no significant effects upon plaque or gingivitis were obtainable in either the
placebo or the vitamin E groups. However, use of 0.12% chlorhexidine significantly
reduced plaque. These results do not support the use of vitamin E as a topical
chemotherapeutic agent for the control of gingivitis or periodontal disease.
AN - rayyan-563561158
AU - Cohen, R. E.
AU - Ciancio, S. G.
AU - Mather, M. L.
AU - Curro, F. A.
IS - 5
KW - alpha tocopherol
chlorhexidine
adult
article
clinical trial
comparative study
controlled study
gel
human
mouth hygiene
periodontal disease
periodontics
tooth plaque
LA - English
PY - 1991
SN - 0163-9633
SP - 20-24
ST - Effect of vitamin E gel, placebo gel and chlorhexidine on periodontal disease
T2 - Clin Prev Dent
TI - Effect of vitamin E gel, placebo gel and chlorhexidine on periodontal disease
VL - 13
ID - 14532
ER -
TY - JOUR
AB - Purpose of Review: Although detailed guidelines exist for the general
treatment of pemphigus, reviews specific to inpatient management are sparse. This
paper will seek to provide a comprehensive and centralized guide for the treatment
of this disease by the inpatient dermatologist. Recent Findings: Important recent
findings include the demonstrated efficacy of rituximab as a first-line agent in
pemphigus and its approval by the FDA for the treatment of moderate-to-severe
pemphigus in adults in 2018. Summary: Optimal care for pemphigus in the hospital
requires a multi-disciplinary approach, which factors in specific qualities of each
patient to develop the proper medication regimen and treatment plan. In addition,
proper wound and oral care, diet, and prophylaxis against potential complications
are all crucial to timely and appropriate discharge.
AN - rayyan-563559787
AU - Cole, C.
AU - Amber, K.
DO - 10.1007/s13671-022-00369-2
IS - 4
KW - ELISA kit
alpha tocopherol
amphotericin B
azathioprine
betamethasone
bisphosphonic acid derivative
chlorhexidine
clobetasol
corticosteroid
cotrimoxazole
cyclophosphamide
dexamethasone
diphenhydramine
doxycycline
etidronic acid
fluconazole
folic acid
ganciclovir
glucocorticoid
hemoglobin A1c
hydrogel
immunoglobulin
immunoglobulin A
ketamine
lidocaine
magnesium oxide
methylprednisolone
minocycline
mycophenolate mofetil
nystatin
omeprazole
pentamidine
phenylbutazone
prednisolone
prednisone
proton pump inhibitor
rifampicin
rituximab
tacrolimus
tetracycline
thiopurine methyltransferase
vancomycin
vitamin D
anaphylaxis
anemia
anxiety
aphthous stomatitis
aseptic meningitis
Autoimmune Bullous Skin Intensity and Severity Score
body surface
bullous pemphigoid
bullous skin disease
chill
cytopenia
dermatologist
diet
drug efficacy
dysphagia
erythema multiforme
fatigue
gastroesophageal reflux
gastrointestinal hemorrhage
gastrointestinal infection
headache
herpes virus infection
herpetic stomatitis
hospital patient
human
hyperglycemia
hypertension
immunofluorescence
infection
leukopenia
liver toxicity
malignant neoplasm
mouth hygiene
nausea and vomiting
neutropenia
osteopenia
osteoporosis
pancreatitis
pemphigus
Pemphigus Disease Area Index
pemphigus foliaceus
pemphigus vulgaris
periodontal disease
plasma exchange
plasmapheresis
prophylaxis
pruritus
review
Roux-en-Y gastric bypass
scoring system
sepsis
systemic lupus erythematosus
venous thromboembolism
vomiting
wound care
LA - English
PY - 2022
SN - 2162-4933
SP - 221-232
ST - Pemphigus for the Inpatient Dermatologist
T2 - Curr. Dermatol. Rep.
TI - Pemphigus for the Inpatient Dermatologist
VL - 11
ID - 13161
ER -
TY - JOUR
AB - The search for new topical treatments able to display not only antimicrobial
properties but also a multiplicity of other beneficial effects while expressing
safe cytocompatibility toward host tissues is being progressively developed.
Antiseptics represent an aid to the gold standard nonsurgical treatment Scaling-
and-Root-Planing (SRP) for periodontal disease. This split-mouth study aims to
assess the efficacy of the ozonized gel GeliO(3) (Bioemmei Srl, Vicenza, Italy)
plus SRP (experimental treatment), with respect to SRP + chlorhexidine gel. Ten
participants were treated with SRP + chlorhexidine gel (control sites) and with SRP
+ ozone gel (trial sites). After 1 (T(1)) and 3 months (T(2)) from baseline (T(0)),
patients were revisited. At each time-point, the following indexes were assessed:
probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI),
plaque index (PI), and bleeding on probing (BoP). It has been assessed that the use
of the ozonized gel in addition to SRP did not show significant differences if
compared to conventional SRP + chlorhexidine. Chlorhexidine was found to be more
effective than ozone in reducing CAL and GI at T(2). Ozone deserves consideration
for its wide applicability in several clinical fields. In this connection, we also
glance at the latest research on ozone therapy.
AN - rayyan-563561288
AU - Colombo, M.
AU - Gallo, S.
AU - Garofoli, A.
AU - Poggio, C.
AU - Arciola, C. R.
AU - Scribante, A.
DO - 10.3390/biology10070625
IS - 7
J2 - Biology (Basel)
LA - eng
N1 - Section of Dentistry, Department of Clinical, Surgical, Diagnostic and
Paediatric Sciences, University of Pavia, Piazzale Golgi 2, 27100 Pavia, Italy.;
Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Paediatric
Sciences, University of Pavia, Piazzale Golgi 2, 27100 Pavia, Italy.; Section of
Dentistry, Department of Clinical, Surgical, Diagnostic and Paediatric Sciences,
University of Pavia, Piazzale Golgi 2, 27100 Pavia, Italy.; Section of Dentistry,
Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of
Pavia, Piazzale Golgi 2, 27100 Pavia, Italy.; Laboratorio di Patologia delle
Infezioni Associate all'Impianto, IRCCS Istituto Ortopedico Rizzoli, Via di
Barbiano 1/10, 40136 Bologna, Italy.; Department of Experimental, Diagnostic and
Specialty Medicine, University of Bologna, Via San Giacomo 14, 40136 Bologna,
Italy.; Section of Dentistry, Department of Clinical, Surgical, Diagnostic and
Paediatric Sciences, University of Pavia, Piazzale Golgi 2, 27100 Pavia, Italy.
PY - 2021
SN - 2079-7737 (Print)
ST - Ozone Gel in Chronic Periodontal Disease: A Randomized Clinical Trial on the
Anti-Inflammatory Effects of Ozone Application
T2 - Biology
TI - Ozone Gel in Chronic Periodontal Disease: A Randomized Clinical Trial on the
Anti-Inflammatory Effects of Ozone Application
VL - 10
Y2 - 7 y3 - 6
ID - 14662
ER -
TY - JOUR
AB - Cells from explants were cultured in the presence of [L-35S]-methionine for
24 h. Cultures containing cycloheximide or cultures frozen immediately after
addition of labelled methionine served as controls. The medium was removed and,
after washing, cells were disrupted by repeated freezing and thawing. Synthesis of
alpha 2-macroglobulin (alpha 2-M) was evaluated by autoradiography of the SDS-PAGE
patterns obtained with the culture medium, and by autoradiography of the crossed
immunoelectrophoretic patterns obtained with both the cell extract and the culture
medium. There was incorporation of labelled methionine in newly-synthesized alpha
2-M. No autoradiographic bands were found in the frozen preparations, and there was
a progressive inhibition of globulin synthesis in the presence of increasing
concentrations of cycloheximide. This synthesis of alpha 2-M by human gingival
fibroblasts may explain the presence of free alpha 2-M in gingival fluid and might
be of significance in the control of proteolysis during gingivitis and
periodontitis.
AN - rayyan-563561178
AU - Condacci, I.
AU - Cimasoni, G.
AU - Rey, M.
AU - Baehni, P.
IS - 6
KW - alpha 2 macroglobulin
cycloheximide
article
biosynthesis
cell culture
crossed immunoelectrophoresis
cytology
drug effect
fibroblast
gingiva
human
metabolism
LA - English
PY - 1988
SN - 0003-9969
SP - 407-412
ST - In-vitro synthesis of alpha 2-macroglobulin by human gingival fibroblasts
TI - In-vitro synthesis of alpha 2-macroglobulin by human gingival fibroblasts
VL - 33
ID - 14552
ER -
TY - JOUR
AN - rayyan-563561179
AU - Cop, L.
AU - Korbar-Smid, J.
AU - Kristl, J.
AU - Groselj, D.
IS - 3
KW - macrogol derivative
metronidazole
article
human
hydrogel
periodontic device
periodontitis
LA - Serbian
PY - 1988
SN - 0044-4928
SP - 95-98
ST - Bioadhesive polymeric films for the application onto the oral mucosa
T2 - Bioadhezivni polimerni filmi za nanasanje na ustno sluznico.
TI - Bioadhesive polymeric films for the application onto the oral mucosa
VL - 43
ID - 14553
ER -
TY - JOUR
AB - AIM: To investigate the presence of resolvins E1 (RvE1) and D2 (RvD2) in
teeth with primary endodontic infections and apical periodontitis, and to assess
the influence of calcium hydroxide medication [Ca(OH)2 ], in association with 2%
chlorhexidine gel (2% CHX gel), and N-acetylcysteine (NAC) on the levels of RvE1
and RvD2 in periapical tissues. METHODOLOGY: Thirty-six single-rooted teeth with
primary endodontic infections and apical periodontitis were selected and randomly
divided into three groups according to the medication: [Ca(OH)2 ] + saline solution
(SSL) [Ca(OH)2 + SSL group] (n = 12), Ca(OH)2 + 2% chlorhexidine gel [Ca(OH)2 + 2%
CHX gel group] (n = 12) and NAC [NAC group] (n = 12). Samples were collected from
the periapical interstitial fluid at two different sampling times: before (S1) and
after 14 days of intracanal medications (S2). Resolvins were measured using the
enzyme-linked immunosorbent assay. Data were analysed using paired t-test, Wilcoxon
test and Kruskal-Wallis test, followed by Dunn's post hoc test; all statistical
tests were performed at a significance level of 5%. RESULTS: RvE1 and RvD2 were
detected in 100% of the samples (36/36) at S1 and S2. Ca(OH)2 medication did not
increase the levels of RvE1 or RvD2 (both P > 0.05); however, NAC significantly
increased the levels of RvE1 and RvD2 after 14 days of treatment (P < 0.05).
CONCLUSIONS: RvE1 and RvD2 were detected in periapical tissues from teeth with root
canal infections. Moreover, calcium hydroxide medication did not increase the
levels of resolvins in apical periodontitis. In contrast, the use of NAC intracanal
medication significantly increased the levels of RvE1 and RvD2 after 14 days of
treatment.
AN - rayyan-563560059
AU - Corazza, B. J. M.
AU - Martinho, F. C.
AU - Khoury, R. D.
AU - Toia, C. C.
AU - Orozco, E. I. F.
AU - Prado, R. F.
AU - Machado, F. P.
AU - Valera, M. C.
DO - 10.1111/iej.13403
IS - 1
KW - acetylcysteine
biomedical and dental materials
calcium hydroxide
chlorhexidine
dental pulp cavity
human
LA - English
PY - 2021
SN - 1365-2591
SP - 61-73
ST - Clinical influence of calcium hydroxide and N-acetylcysteine on the levels of
resolvins E1 and D2 in apical periodontitis
T2 - Int Endod J
TI - Clinical influence of calcium hydroxide and N-acetylcysteine on the levels of
resolvins E1 and D2 in apical periodontitis
VL - 54
ID - 13433
ER -
TY - JOUR
AB - Objectives: Despite the excellent properties of both pure bioglasses (BG) and
BG doped with therapeutic ions (such as Li) in hard tissue applications, there is
not enough information about their role in the remineralization and bacterial-
growth in oral diseases. The aim of this contribution is to evaluate the effect of
both pure BG and BG doped with 5-wt% of Li (BGLi) on both the remineralization of
in vitro demineralized human-teeth and the antimicrobial behavior against strains
from caries and periodontitis. Methods: Bioglass (R) 45S5 (BG) and BGLi were
synthesized by the sol-gel method. The remineralization tests were carried out
using in vitro demineralized enamel teeth and evaluated by Electron Microscopy
(SEM) and Vickers micro-hardness (HV). The antimicrobial behavior of the particles
was evaluated against S. mutans, A. actinomycetemcomitans, and P. gingivalis,
representing pathogens from caries and periodontitis. Results: Enamel lesion was
partially remineralized when both bioglasses (BG and BGLi) were applied on its
surface with micro-hardness recoveries around 45 %. They further inhibited the
growth of S. mutans and P. gingivalis, at 50 and 200 mg/mL, respectively. BGLi
presented a higher toxicity against A. actinomycetemcomitans than BG, with
inhibition concentrations of 20 mg/mL and 100 mg/mL, respectively. Conclusions:
Bioglasses could be used in the treatment of two of the most prevalent oral
diseases: caries and periodontitis, promoting the remineralization of the teeth and
killing the main pathogens. The presence of Li did not affect the bioactivity of
the bioglass and improved the antibacterial effect over A. actinomycetemcomitans
strain.
AN - rayyan-563562368
AU - Cordero, H. P.
AU - Cid, R. C.
AU - Dosque, M. D.
AU - Ibacache, R. C.
AU - Fluxa, P. P.
PY - 2021
SN - ["0300-5712", "1879-176X"]
ST - Li-doped bioglass (R) 45S5 for potential treatment of prevalent oral diseases
T2 - JOURNAL OF DENTISTRY
TI - Li-doped bioglass (R) 45S5 for potential treatment of prevalent oral diseases
VL - 105
Y2 - 2
ID - 15742
ER -
TY - JOUR
AB - Abstract: Surgical meshes have been employed in the management of a variety
of pathological conditions including hernia, pelvic floor dysfunctions, periodontal
guided bone regeneration, wound healing and more recently for breast plastic
surgery after mastectomy. These common pathologies affect a wide portion of the
worldwide population; therefore, an effective and enhanced treatment is crucial to
ameliorate patients’ living conditions both from medical and aesthetic points of
view. At present, non-absorbable synthetic polymers are the most widely used class
of biomaterials for the manufacturing of mesh implants for hernia, pelvic floor
dysfunctions and guided bone regeneration, with polypropylene and poly
tetrafluoroethylene being the most common. Biological prostheses, such as surgical
grafts, have been employed mainly for breast plastic surgery and wound healing
applications. Despite the advantages of mesh implants to the treatment of these
conditions, there are still many drawbacks, mainly related to the arising of a huge
number of post-operative complications, among which infections are the most common.
Developing a mesh that could appropriately integrate with the native tissue,
promote its healing and constructive remodelling, is the key aim of ongoing
research in the area of surgical mesh implants. To this end, the adoption of new
biomaterials including absorbable and natural polymers, the use of drugs and
advanced manufacturing technologies, such as 3D printing and electrospinning, are
under investigation to address the previously mentioned challenges and improve the
outcomes of future clinical practice. The aim of this work is to review the key
advantages and disadvantages related to the use of surgical meshes, the main issues
characterizing each clinical procedure and the future directions in terms of both
novel manufacturing technologies and latest regulatory considerations. Graphic
abstract: [Figure not available: see fulltext.]
AN - rayyan-563559984
AU - Corduas, F.
AU - Lamprou, D. A.
AU - Mancuso, E.
DO - 10.1007/s42242-020-00108-1
IS - 2
KW - acellular dermal matrix
Bio-Gide
flow cytometer
polytetrafluoroethylene
Guidor
Gynecare gynemesh
hernia mesh
suburethral sling
surgical mesh
surgical staple
surgical tape
syringe
TIGR
TiLoop
tissue scaffold
vaginal mesh
wound dressing
wound matrix
alginic acid
ascorbic acid
ascorbic acid 2 phosphate
biomaterial
bone morphogenetic protein
calcium phosphate
carvacrol
chitosan
chloroform
ciprofloxacin
collagen
gelatin
hyaluronic acid
hydrogel
levofloxacin
metronidazole
milk protein
ofloxacin
polyglycolic acid
polymer
polypropylene
polyurethan
povidone
quinoline derived antiinfective agent
rifampicin
silicone
sodium chloride
squalene
tetracycline
tetrahydrofuran
thymol
tissue adhesive
tyrosol
abdominal wall hernia
anterior colporrhaphy
biocompatibility
biodegradability
bone defect
bone regeneration
breast surgery
cell adhesion
cell growth
chronic pain
cytotoxicity
drug stability
dyspareunia
equipment design
fused deposition modeling
hematoma
hernia
honey
hot melt extrusion
human
hydrophilicity
laparoscopy
lifestyle modification
mastectomy
nonhuman
pelvic floor disorder
plastic surgery
pubovaginal sling procedure
quality of life
recurrent disease
review
sacrocolpopexy
selective laser sintering
seroma
three dimensional bioprinting
tissue engineering
wound healing
Cytoflex
Dermagraft
Gore-Tex
Transcyte
Upsylon
LA - English
PY - 2021
SN - ["2522-8552", "2096-5524"]
SP - 278-310
ST - Next-generation surgical meshes for drug delivery and tissue engineering
applications: materials, design and emerging manufacturing technologies
T2 - Bio-Des. Manufact.
TI - Next-generation surgical meshes for drug delivery and tissue engineering
applications: materials, design and emerging manufacturing technologies
VL - 4
ID - 13358
ER -
TY - GEN
AB - A proposta deste estudo foi investigar a citotoxicidade, ação antimicrobiana
e pH do cimento Portland puro (CP) e associações com agentes radiopacificadores:
óxido de bismuto (CPBi), óxido de zircônio (CPZir), tungstato de cálcio (CPCa).
Para avaliar o potencial citotóxico, foram empregadas linhagens celulares de
fibroblastos do ligamento periodontal de camundongos (mPDL) e osteosarcoma de ratos
(ROS 17/2.8). Ambas foram expostas por 24 horas a diferentes concentrações do CP
fresco, CP associado com radiopacificadores e cimento de óxido de zinco eugenol.
Peróxido de hidrogênio foi aplicado como controle positivo para apoptose. A
viabilidade após incubação com os cimentos foi avaliada pela atividade da enzima
desidrogenase mitocondrial. A morfologia celular foi analisada microscopicamente
pelo corante violeta de cresilo, e o mecanismo de morte celular foi determinado
pela metodologia de laranja de acridina/brometo de etídio. Os dados foram
analisados estatisticamente por ANOVA e Tukey post-test (p<0.01). A correlação
entre os dois tipos de morte celular e valores de pH foi estabelecido pela
correlação linear de Pearson. O ensaio da enzima desidrogenase mitocondrial revelou
um padrão significante de morte celular apenas nas altas concentrações dos eluídos
de cimento. CP puro não foi citotóxico, mesmo na alta concentração de 100mg/ml. As
imagens microscópicas mostraram que nenhuma das formulações de CP causaram danos as
linhagens celulares. Análises estatísticas dos dados de apoptose/necrose demonstram
que CP e CP mais agentes radiopacificadores promoveram morte por necrose
estatisticamente significativa apenas em 100mg/ml. Os resultados mostraram que CP
associado com óxido de bismuto, óxido de zircônio ou tungstato de cálcio não foram
citotóxicos para mPDL ou ROS 17/2.8, e podem ser boas alternativas como agentes
radiopacificadores. A ação antimicrobiana e o pH do cimento Portland e agentes
radiopacificadores foram avaliadas. Para a ação antimicrobiana utilizamos a difusão
em agar. Foram avaliados quanto à ação antimicrobiana: cimento Portland puro, e
associações com agentes radiopacificadores (óxido de bismuto, óxido de zircônio e
tungstato de cálcio) além do cimento óxido de zinco eugenol (ZOE), pela técnica do
poço em duas camadas. Serão utilizadas as seguintes cepas: Micrococcus luteus,
Streptococcus mutans, Enterococcus faecalis, Pseudomonas aeruginosa e Candida
Albicans. As imagens das placas bem iluminadas e com fundo na cor azul,
contrastando com a coloração rósea das colônias vivas após o uso do gel de TTC
foram digitalizadas e o diâmetro dos halos de inibição formados ao redor do poço
foram mensurados com o auxílio do programa Image Tool (UTHSCSA Image Tool for
Windows version 3.00). Os resultados foram expressos em médias. Já para a avaliação
do pH, foram preparados 10 tubos padronizados preenchidos com os cimentos
avaliados, num total de 50 tubos com os mesmos grupos. Após 12, 24, 48 e 72 horas,
o pH foi avaliado com um pHmêtro Ultrabasic (Denver Instrument Company, Arvada,
Colorado, USA). Os resultados obtidos foram submetidos a um teste de normalidade,
posteriormente submetidos ao teste estatístico paramétrico ANOVA para comparação
dos diferentes grupos entre si e ao teste de comparações múltiplas de Tukey, com 5%
de significância
The purpose of this study was to investigate the cytotoxicity, antimicrobial and pH
of pure Portland cement (PC), and associations with radiopacifier agents: bismuth
oxide (CPBi), zirconium oxide (CPZir), calcium tungstate (CPCA). To assess the
potential cytotoxicity, fibroblast cell lines from the periodontal ligament of mice
(mPDL) and rat osteosarcoma (ROS 17/2.8) were used. Both were exposed for 24 hours
with different concentrations of fresh PC, PC associated with radiopacifiers and
eugenol zinc oxide cement. Hydrogen peroxide was used as a positive control for
apoptosis. The viability after incubation with the cements was evaluated by
mitochondrial dehydrogenase enzyme activity. Cell morphology was examined
microscopically by cresyl violet stain, and the mechanism of cell death was
determined by the method of acridine orange / ethidium bromide. The data were
statistically analyzed by ANOVA and Tukey post-test (p <0.01). The correlation
between the two types of cell death and pH values was established by Pearson linear
correlation. The mitochondrial dehydrogenase enzyme assay revealed a significant
pattern of cell death only at high concentrations of the eluted cement. Pure PC was
not cytotoxic, even at high concentration of 100mg/ml. Microscopic images showed
that none of the formulations of PC caused damage cell lines. Statistical analysis
of apoptosis/necrosis data showed that PC and PC plus radiopacifiers agents
promoted death by necrosis statistically significant only at 100mg/ml. The results
showed that PC associated with bismuth oxide, zirconium oxide or calcium tungstate
were not toxic to ROS 17/2.8 or mPDL, and may be good alternatives as radiopacifier
agents. The antimicrobial and pH of Portland cement and radiopacifier agents were
evaluated. For antimicrobial activity agar diffusion was used. For antimicrobial
activity, pure Portland cement, and associations with radiopacifier agents (bismuth
oxide, zirconium oxide and calcium tungstate) were used as well as cement zinc
oxide eugenol (ZOE) by means of the well method in two layers. The following
strains were employed: Micrococcus luteus, Streptococcus mutans, Enterococcus
faecalis, Pseudomonas aeruginosa and Candida albicans. The images of the cards and
well lit with deep blue color, contrasting with the bright pink color of the
colonies after the use of TTC gel. The diameter of inhibition zones formed around
the well was measured using the Image Tool (UTHSCSA Image Tool for Windows version
3.00). Results were expressed as means. For the evaluation of pH, 10 standard tubes
filled with the same sealers were prepared, resulting in a total of 50 tubes. After
12, 24, 48 and 72 hours, pH was measured with a pH Ultrabasic (Denver Instrument
Company, Arvada, Colorado, USA). The results were submitted to a normality test,
and then subjected to statistical parametric ANOVA test for comparison of different
groups and to the multiple comparison Tukey test at 5% significance level
AN - rayyan-563559882
AU - Cornélio, Ana Lívia Gomes
KW - Apoptose
Apoptosis
Citotoxicity tests
Endodontia
Endodontics
Testes de citoxicidade
LA - pt
PY - 2011
SP - 87-87
ST - Citotoxicidade e ação antimicrobiana e do cimento Portland associado a
diferentes agentes radiopacificadores
TI - Citotoxicidade e ação antimicrobiana e do cimento Portland associado a
diferentes agentes radiopacificadores
UR -
https://repositorio.unesp.br/bitstream/handle/11449/90397/cornelio_alg_me_arafo.pdf
?sequence=1&isAllowed=y
ID - 13256
ER -
TY - JOUR
AN - rayyan-563561168
AU - Cortellini, P.
AU - De Sanctis, M.
AU - Pini Prato, G.
AU - Clauser, C.
AU - Luzi, R.
AU - Miracco, C.
IS - 5
KW - chlorhexidine
animal
article
connective tissue
dog
drug effect
gel
inflammation
neutrophil
osteoclast
osteolysis
periodontitis
tooth plaque
LA - English
PY - 1990
SN - 0198-7569
SP - 392-407
ST - Effects of a 1% chlorhexidine gel (corsodyl) on the bone resorption and
inflammation associated with experimentally induced periodontitis in dogs
T2 - Int J Periodontics Restorative Dent
TI - Effects of a 1% chlorhexidine gel (corsodyl) on the bone resorption and
inflammation associated with experimentally induced periodontitis in dogs
VL - 10
ID - 14542
ER -
TY - JOUR
AB - The clinician is frequently faced with poor treatment outcome of scaling and
root planing predominantly in deep pockets and furcations. In an attempt to
optimize clinical effects at these weakly responding sites chemo-mechanical
treatment strategies have been developed and studied, among those using
chlorhexidine as an antimicrobial agent. In this overview the clinical effects of
subgingival chlorhexidine irrigation, gel, chip and varnish administration as an
adjunct to scaling and root planing in the treatment of periodontitis are
discussed. There is little to no evidence indicating treatment outcome will benefit
from subgingival irrigation using chlorhexidine solutions. Furthermore, the use of
a chlorhexidine solution as a coolant during (ultra)sonic scaling does not result
in a clinically superior response when compared to water cooling. Despite the high
viscosity of a gel, its use cannot be justified in the treatment of periodontitis
as clinical effects are also negligible. Multi-center studies have indicated
significantly higher pocket reductions and clinical attachment gains following a
combination of scaling and root planing and the administration of a chlorhexidine
chip. As some studies failed to confirm this finding, more research is needed to
elucidate the additional value of the chip. The subgingival administration of a
supersaturated chlorhexidine varnish seems promising as additive clinical effects
have been reported. Large-scale studies are however lacking on this treatment
concept. The clinician should continue treating periodontitis primarily by
mechanical means. Supplemental chemical therapy based on subgingival chlorhexidine
administration can be considered; yet, solutions and gels are not suitable as
compensatory aids when scaling and root planing becomes less effective.
AN - rayyan-563560732
AU - Cosyn, J.
AU - De Bruyn, H.
AU - Sabzevar, M. M.
IS - 4
KW - chlorhexidine
drug derivative
EC40 dental varnish
article
gel
gingivitis
human
lavage
periodontitis
solution and solubility
LA - French
PY - 2007
SN - 0035-080X
SP - 176-182
ST - Subgingival application of chlorhexidine in the treatment of periodontitis
T2 - Application sous-gingivale de chlorhexidine dans le traitement de la
parodontite.
TI - Subgingival application of chlorhexidine in the treatment of periodontitis
VL - 62
ID - 14106
ER -
TY - JOUR
AB - The clinician is frequently faced with poor treatment outcome of scaling and
root planing predominantly in deep pockets and furcations. In an attempt to
optimize clinical effects at these weakly responding sites chemo-mechanical
treatment strategies have been developed and studied, among those using
chlorhexidine as an antimicrobial agent. In this overview the clinical effects of
subgingival chlorhexidine irrigation, gel, chip and varnish administration as an
adjunct to scaling and root planing in the treatment of periodontitis are
discussed. There is little to no evidence indicating treatment outcome will benefit
from subgingival irrigation using chlorhexidine solutions. Furthermore, the use of
a chlorhexidine solution as a coolant during (ultra)sonic scaling does not result
in a clinically superior response when compared to water cooling. Despite the high
viscosity of a gel, its use cannot be justified in the treatment of periodontitis
as clinical effects are also negligible. Multi-center studies have indicated
significantly higher pocket reductions and clinical attachment gains following a
combination of scaling and root planing and the administration of a chlorhexidine
chip. As some studies failed to confirm this finding, more research is needed to
elucidate the additional value of the chip. The subgingival administration of a
supersaturated chlorhexidine varnish seems promising as additive clinical effects
have been reported. Large-scale studies are however lacking on this treatment
concept. The clinician should continue treating periodontitis primarily by
mechanical means. Supplemental chemical therapy based on subgingival chlorhexidine
administration can be considered; yet, solutions and gels are not suitable as
compensatory aids when scaling and root planing becomes less effective.
AN - rayyan-563561442
AU - Cosyn, J.
AU - De Bruyn, H.
IS - 4
J2 - Rev Belge Med Dent (1984)
KW - Anti-Infective Agents, Local/*administration & dosage
Chlorhexidine/*administration & dosage/analogs & derivatives/therapeutic use
Dental Scaling
Gels/therapeutic use
Gingival Pocket
Humans
Periodontitis/*drug therapy/therapy
Solutions/therapeutic use
Therapeutic Irrigation
LA - fre
N1 - Vrije Universiteit Brussel (VUB), Ecole de Médecine Dentaire, Département de
Parodontologie & d'Implantologie Orale, Avenue du Laarbeek 103, B-1090 Bruxelles,
Belgique. jan.cosyn@vub.ac.be
PY - 2007
SN - 0775-0293 (Print)
SP - 176-82
ST - [Subgingival application of chlorhexidine in the treatment of periodontitis]
T2 - Revue belge de medecine dentaire
TI - [Subgingival application of chlorhexidine in the treatment of periodontitis]
VL - 62
ID - 14816
ER -
TY - JOUR
AB - Background: Since scaling and root planing are not always successful,
predominantly when access to periodontal defects is compromised, various
antimicrobial agents as adjuncts have been suggested to enhance their efficacy. Gel
vehicles delivering chlorhexidine (CHX) have become available and tested for these
indications. Methods: An electronic (MEDLINE and Cochrane Oral Health Group
Specialized Trials Register) and manual search were made to detect studies
concerning the use of chlorhexidine gels as a single measure of treatment and as an
adjunct to scaling and root planing. Only full-text randomized controlled trials
published in English up to January 2005 were included. Results: Eight studies were
finally selected. Due to considerable heterogeneity in study design and outcome
variables measured a qualitative data analysis was performed. There is evidence
that subgingival chlorhexidine gel administration as a monotherapy temporarily
reduces bleeding tendency on probing; a clinical effect coinciding with relevant
microbiological changes described in all but one study. To what extent chemical
effects contribute to these changes appears to be related to the frequency of gel
administration. There seem to be little to no data indicating that the treatment
outcome of scaling and root planing will benefit from the adjunctive subgingival
administration of a CHX gel. Conclusion: The limited data currently available on
the effects of subgingival chlorhexidine gel application do not justify its use in
the treatment of chronic periodontitis.
AN - rayyan-563560780
AU - Cosyn, J.
DO - 10.1902/jop.2005.76.11.1805
IS - 11
KW - chlorhexidine
metronidazole
placebo
stannous fluoride
tetracycline
adjuvant therapy
bleeding tendency
chronic disease
clinical trial
Cochrane Library
dental procedure
gel
human
Medline
monotherapy
periodontitis
qualitative analysis
review
systematic review
treatment outcome
LA - English
PY - 2005
SN - 0022-3492
SP - 1805-1813
ST - A systematic review on the effects of subgingival chlorhexidine gel
administration in the treatment of chronic periodontitis
TI - A systematic review on the effects of subgingival chlorhexidine gel
administration in the treatment of chronic periodontitis
VL - 76
ID - 14154
ER -
TY - JOUR
AB - Background: Several local antimicrobial agents, such as a bioabsorbable
chlorhexidine chip, have been developed to enhance the outcome of non-surgical
periodontal therapy. Methods: Electronic (MEDLINE and Cochrane Oral Health Group
Specialized Trials Register) and manual searches were performed to detect studies
concerning the use of the chlorhexidine chip as an adjunct to scaling and root
planing in the treatment of chronic periodontitis. Only full-text randomized
controlled trials published in English up to June 2005 were included. Results: Five
studies were finally selected following independent screening by two reviewers. Due
to considerable heterogeneity in study design, a qualitative data analysis was
performed. Multicenter studies have indicated significantly higher pocket
reductions and clinical attachment gains following a combination of mechanical
debridement and repeated chlorhexidine chip administration in comparison to scaling
and root planing alone. However, some recent studies failed to confirm the
additional value of the chlorhexidine chip. A number of interstudy disparities with
respect to methodological quality and study design may account for this lack of
accordance. Conclusions: The clinical and microbiological data currently available
on the chlorhexidine chip are limited and conflicting. More research is needed to
elucidate the additional value of the chlorhexidine chip when used as an adjunct to
scaling and root planing.
AN - rayyan-563562397
AU - Cosyn, J.
AU - Wyn, I.
DO - 10.1902/jop.2006.050216
IS - 2
PY - 2006
SN - ["0022-3492", "1943-3670"]
SP - 257-264
ST - A systematic review on the effects of the chlorhexidine chip when used as an
adjunct to scaling and root planing in the treatment of chronic periodontitis
T2 - JOURNAL OF PERIODONTOLOGY
TI - A systematic review on the effects of the chlorhexidine chip when used as an
adjunct to scaling and root planing in the treatment of chronic periodontitis
VL - 77
Y2 - 2
ID - 15771
ER -
TY - JOUR
AB - Silver nanoparticles (AgNP) suspensions were biosynthesized by silver ions
reduction in the presence of collagen, a nontoxic, organic polymer, intending to
improve their medical use in periodontitis treatment. Spectrophotometric
measurements showed a time- and concentration-dependent increase of AgNP formation
in each suspension variant. Transmission electron microscopy revealed spherical
morphology of AgNP in collagen and their mean diameter size was around 30 nm. The
particle size distribution and zeta potential values of AgNP in collagen were
determined by dynamic light scattering measurements. The surface charge of AgNP in
collagen was positive, while commercial AgNP stabilized in citrate had negative
surface charge. In vitro cytotoxicity testing of AgNP in collagen showed that they
were biocompatible with human gingival fibroblasts in a wider range of
concentrations than commercial nanoparticles. The antibacterial activity of AgNP in
collagen against two pathogenic strains present in the periodontal pocket was dose-
dependent and higher than that of AgNP in citrate. All these results demonstrated
that AgNP prepared in collagen gel had improved properties, like small diameter,
positive surface charge, high biocompatibility in human gingival fibroblasts,
efficiency against bacterial growth and, thus, better therapeutic potential in
periodontal disease treatment.
AN - rayyan-563560179
AU - Craciunescu, O.
AU - Seciu, A. M.
AU - Manoiu, V. S.
AU - Trif, M.
AU - Moisei, M.
AU - Nicu, A. I.
AU - Zarnescu, O.
DO - 10.1080/02726351.2018.1455780
IS - 6
KW - citric acid
collagen gel
silver nanoparticle
article
bacterial growth
biocompatibility
biosynthesis
cell viability
concentration response
cytotoxicity test
dispersity
fibroblast
gingiva
growth inhibition
human
human cell
in vitro study
nonhuman
particle size
periodontal disease
periodontal pocket
periodontitis
photon correlation spectroscopy
priority journal
surface charge
zeta potential
LA - English
PY - 2019
SN - ["1548-0046", "0272-6351"]
SP - 757-763
ST - Biosynthesis of silver nanoparticles in collagen gel improves their medical
use in periodontitis treatment
T2 - Part. Sci. Technol.
TI - Biosynthesis of silver nanoparticles in collagen gel improves their medical
use in periodontitis treatment
VL - 37
ID - 13553
ER -
TY - JOUR
AN - rayyan-563561820
AU - Cristea, A. D.
AU - Preoteasa, C. T.
AU - Popa, M.
AU - Marutescu, L.
AU - Chifiriuc, M. C.
AU - Gheorghe, I.
AU - Lazar, V.
AU - Iliescu, A. A.
AU - Perlea, P.
AU - Moldoveanu, G. F.
AU - Suciu, I.
IS - 1
PY - 2016
SP - 11217-11224
ST - In Vitro testing of susceptibility to endodontic irrigants and disinfectants
of bacterial strains isolated from chronic apical periodontitis
T2 - Romanian Biotechnological Letters
TI - In Vitro testing of susceptibility to endodontic irrigants and disinfectants
of bacterial strains isolated from chronic apical periodontitis
84963502838&partnerID=40&md5=64db6689b81705a2934c574df1082024
VL - 21
ID - 15194
ER -
TY - JOUR
AN - rayyan-563560844
AU - Csányi, E.
AU - Fehér, A.
AU - Urbán, E.
AU - Eros, I.
KW - chlorhexidine
clindamycin
metronidazole
oil
polymer
surfactant
agar diffusion
article
drug coating
drug efficacy
drug formulation
Fusobacterium varium
hydrogel
incubation time
inoculation
liquid crystal
priority journal
LA - English
PY - 2005
SN - 0928-0987
SP - S70-S72
ST - Side-specific drug delivery systems for the treatment of periodontal diseases
T2 - Eur. J. Pharm. Sci.
TI - Side-specific drug delivery systems for the treatment of periodontal diseases
VL - 25
ID - 14218
ER -
TY - JOUR
AB - Periodontitis is a chronic infectious disease caused by bacterial irritation.
As an essential component of the host immunity, macrophages are highly plastic and
play a crucial role in inflammatory response. An appropriate and timely transition
from proinflammatory (M1) to anti-inflammatory (M2) macrophages is indispensable
for treating periodontitis. As M2 macrophage-derived exosomes (M2-exos) can
actively target inflammatory sites and modulate immune microenvironments, M2-exos
can effectively treat periodontitis. Excessive endoplasmic reticulum stress (ER
stress) and unfolded protein response (UPR) are highly destructive pathological
characteristics during inflammatory periodontal bone loss. Although melatonin has
antioxidant and anti-inflammatory effects, studies focusing on melatonin ER stress
modulation remain limited. This study fabricates engineered M2-exos loading with
melatonin (Mel@M2-exos) for treating periodontitis. As a result, M2-exos drive an
appropriate and timely macrophage reprogramming from M1 to M2 type, which resolves
chronic inflammation and accelerated periodontal healing. Melatonin released from
Mel@M2-exos rescues the osteogenic and cementogenic differentiation capacity in
inflammatory human periodontal ligament cells (hPDLCs) by reducing excessive ER
stress and UPR. Injectable gelatin methacryloyl (GelMA) hydrogels with sustained-
release Mel@M2-exos accelerate periodontal bone regeneration in rats with ligation-
induced periodontitis. Taken together, melatonin engineering M2 macrophage-derived
exosomes are promising candidates for inflammatory periodontal tissue regeneration.
AN - rayyan-563559693
AU - Cui, Y.
AU - Hong, S.
AU - Xia, Y.
AU - Li, X.
AU - He, X.
AU - Hu, X.
AU - Li, Y.
AU - Wang, X.
AU - Lin, K.
AU - Mao, L.
DO - 10.1002/advs.202302029
KW - alveolar bone loss
animal cell
animal experiment
article
bone regeneration
controlled study
endoplasmic reticulum stress
exosome
human
M2 macrophage
macrophage
male
microenvironment
nonhuman
periodontitis
rat
surgery
tissue regeneration
unfolded protein response
gelatin
hydrogel
melatonin
LA - English
PY - 2023
SN - 2198-3844
SP - e2302029
ST - Melatonin Engineering M2 Macrophage-Derived Exosomes Mediate Endoplasmic
Reticulum Stress and Immune Reprogramming for Periodontitis Therapy
T2 - Adv Sci (Weinh)
TI - Melatonin Engineering M2 Macrophage-Derived Exosomes Mediate Endoplasmic
Reticulum Stress and Immune Reprogramming for Periodontitis Therapy
ID - 13067
ER -
TY - JOUR
AN - rayyan-563562144
AU - Cummins, D.
AU - Creeth, J. E.
DO - 10.1177/00220345920710071601
IS - 7
PY - 1992
SP - 1439-1449
ST - Delivery of Antiplaque Agents from Dentifrices, Gels, and Mouthwashes
T2 - Journal of Dental Research
TI - Delivery of Antiplaque Agents from Dentifrices, Gels, and Mouthwashes
0026783035&doi=10.1177%2f00220345920710071601&partnerID=40&md5=3d7c0f0e8747672233eb
950136d145fa
VL - 71
ID - 15518
ER -
TY - JOUR
AB - Background: Periodontal disease (PD) is a highly prevalent inflammatory
disease in dogs. This disease is initiated by a polymicrobial biofilm on the teeth
surface, whose control includes its prevention and removal. Recently, it was shown
that nisin displays antimicrobial activity against canine PD-related bacteria.
Moreover, guar gum biogel has shown to be a promising topical delivery system for
nisin. Methods: In this study we aimed to evaluate the antimicrobial activity of
the nisinbiogel in the presence of canine saliva and after a 24-month storage, at
different conditions, using a canine oral enterococci collection. We also studied
the nisin-biogel cytotoxicity using a Vero cell line and canine primary intestinal
fibroblasts. Results: The presence of saliva hampers nisin-biogel antimicrobial
activity, and higher nisin concentrations were required for an effective activity.
A significant reduction (p ≤ 0.05) in inhibitory activity was observed for nisin-
biogel solutions stored at 37 °C, over a 24-month period, which was not observed
with the other conditions. The nisinbiogel showed no cytotoxicity against the cells
tested at concentrations up to 200 µg/mL. Conclusions: Our results confirmed the
potential of the nisin-biogel for canine PD control, supporting the development of
an in vivo clinical trial.
AN - rayyan-563560127
AU - Cunha, E.
AU - Freitas, F. B.
AU - São Braz, B.
AU - da Silva, J. M.
AU - Tavares, L.
AU - Veiga, A. S.
AU - Oliveira, M.
IS - 4
KW - gel
guar gum
nisin
animal cell
article
bioassay
cell viability
controlled study
cytotoxicity
dog
dog disease
drug formulation
Enterococcus faecium
intestinal cell line
MTT assay
nonhuman
periodontal disease
priority journal
saliva analysis
spot on lawn assay
storage temperature
Vero cell line
zone of inhibition
LA - English
PY - 2020
SN - 2079-6382
ST - Polyphasic validation of a nisin-biogel to control canine periodontal disease
T2 - Antibiotics
TI - Polyphasic validation of a nisin-biogel to control canine periodontal disease
VL - 9
ID - 13501
ER -
TY - JOUR
AB - BackgroundPeriodontal disease (PD) is caused by the development of a
microbial biofilm (dental plaque) in the periodontium, affecting approximately 80%
of dogs. Several bacterial species present in the canine oral cavity can be
implicated in the development of this disease, including Enterococcus spp. To
decrease antibiotic administration, a possible control strategy for dog's
enterococcal PD may involve the use of the antimicrobial peptide (AMP)
nisin.Nisin's inhibitory activity was evaluated against a collection of previously
characterized enterococci obtained from the oral cavity of dogs with PD (n=20), as
well as the potential of a guar-gum gel and a veterinary toothpaste as topical
delivery systems for this AMP. The Minimum Inhibitory (MIC) and Bactericidal
Concentrations (MBC) and the Minimum Biofilm Eradication (MBEC) and Inhibitory
Concentrations (MBIC) were determined for nisin and for the supplemented guar-gum
gel. For the supplemented veterinary toothpaste an agar-well diffusion assay was
used to evaluate its inhibitory potential.ResultsNisin was effective against all
isolates. Independently of being or not incorporated in the guar-gum gel, its
inhibitory activity on biofilms was higher, with MBIC (12.465.16 and 13.60 +/-
4.31g/mL, respectively) and MBEC values (21.87 +/- 11.33 and 42.34 +/- 16.61g/mL)
being lower than MIC (24.61 +/- 4.64 and 14.90 +/- 4.10g/mL) and MBC (63.09 +/-
13.22 and 66.63 +/- 19.55g/mL) values. The supplemented toothpaste was also
effective, showing inhibitory activity against 95% of the isolates.Conclusions The
inhibitory ability of nisin when incorporated in the two delivery systems was
maintained or increased, demonstrating the potential of these supplemented vehicles
to be applied to PD control in dogs.
AN - rayyan-563562493
AU - Cunha, E.
AU - Trovao, T.
AU - Pinheiro, A.
AU - Nunes, T.
AU - Santos, R.
AU - da Silva, J. M.
AU - Sao Braz, B.
AU - Tavares, L.
AU - Veiga, A. S.
AU - Oliveira, M.
DO - 10.1186/s12917-018-1692-9
PY - 2018
SN - 1746-6148
ST - Potential of two delivery systems for nisin topical application to dental
plaque biofilms in dogs
T2 - BMC VETERINARY RESEARCH
TI - Potential of two delivery systems for nisin topical application to dental
VL - 14
Y2 - 11 y3 - 29
ID - 15867
ER -
TY - JOUR
AB - Background: Periodontal disease (PD) is caused by the development of a
microbial biofilm (dental plaque) in the periodontium, affecting approximately 80%
of dogs. Several bacterial species present in the canine oral cavity can be
implicated in the development of this disease, including Enterococcus spp. To
decrease antibiotic administration, a possible control strategy for dog's
enterococcal PD may involve the use of the antimicrobial peptide (AMP) nisin.
Nisin's inhibitory activity was evaluated against a collection of previously
characterized enterococci obtained from the oral cavity of dogs with PD (n = 20),
as well as the potential of a guar-gum gel and a veterinary toothpaste as topical
delivery systems for this AMP. The Minimum Inhibitory (MIC) and Bactericidal
Concentrations (MBC) and the Minimum Biofilm Eradication (MBEC) and Inhibitory
Concentrations (MBIC) were determined for nisin and for the supplemented guar-gum
gel. For the supplemented veterinary toothpaste an agar-well diffusion assay was
used to evaluate its inhibitory potential. Results: Nisin was effective against all
isolates. Independently of being or not incorporated in the guar-gum gel, its
inhibitory activity on biofilms was higher, with MBIC (12.46 ± 5.16 and 13.60 ±
4.31 μg/mL, respectively) and MBEC values (21.87 ± 11.33 and 42.34 ± 16.61 μg/mL)
being lower than MIC (24.61 ± 4.64 and 14.90 ± 4.10 μg/mL) and MBC (63.09 ± 13.22
and 66.63 ± 19.55 μg/mL) values. The supplemented toothpaste was also effective,
showing inhibitory activity against 95% of the isolates. Conclusions: The
inhibitory ability of nisin when incorporated in the two delivery systems was
maintained or increased, demonstrating the potential of these supplemented vehicles
to be applied to PD control in dogs.
AN - rayyan-563560230
AU - Cunha, E.
AU - Trovão, T.
AU - Pinheiro, A.
AU - Nunes, T.
AU - Santos, R.
AU - Moreira Da Silva, J.
AU - São Braz, B.
AU - Tavares, L.
AU - Veiga, A. S.
AU - Oliveira, M.
DO - 10.1186/s12917-018-1692-9
IS - 1
KW - c e t
cefotaxime
chloramphenicol
ciprofloxacin
clindamycin
dalfopristin
gentamicin
guar gum
levofloxacin
nisin
prophylaxis toothpaste
quinupristin
streptomycin
tetracycline
toothpaste
agar diffusion
article
bacterial growth
bacterial virulence
bacterium isolate
biofilm
colony forming unit
dog
drug effect
Enterococcus faecium
in vitro study
inhibitory concentration
minimum biofilm inhibition and eradication concentration
nonhuman
phenotype
tooth plaque
LA - English
PY - 2018
SN - 1746-6148
ST - Potential of two delivery systems for nisin topical application to dental
T2 - BMC Vet. Res.
TI - Potential of two delivery systems for nisin topical application to dental
VL - 14
ID - 13604
ER -
TY - JOUR
AB - The effectiveness of a 1% chlorhexidine-containing dental gel on dental
plaque and gingival health was evaluated over a period of 6 months using a double-
blind procedure. One hundred and seventeen mentally retarded subjects aged between
10-17 years resident in an institution were divided into two groups. One group was
assigned daily brushing with the 1% chlorhexidine gel, the other group a placebo
quinine sulfate- containing gel. No other form of oral hygiene was used during the
experimental period. Assessment of dental plaque accumulation and gingivitis was
made at 0, 1, 3, and 6 months. An assessment was also made 2 months after the gel
was withdrawn from use and normal toothbrushing procedures resumed. No clinical or
statistical advantage was noted in plaque or gingivitis scores in the group
receiving chlorhexidine treatment during the 6-month period. This group showed a
higher prevalence of tooth staining. It was concluded that periodontal severity and
poor oral hygiene exceeded the plaque- and gingivitis-preventing potential of
chlorhexidine.
AN - rayyan-563561202
AU - Cutress, T. W.
AU - Brown, R. H.
AU - Barker, D. S.
IS - 2
KW - chlorhexidine
quinine sulfate
gingivitis
mental deficiency
mouth hygiene
therapy
tooth brushing
tooth plaque
LA - English
PY - 1977
SN - 0301-5661
SP - 78-83
ST - Effects on plaque and gingivitis of a chlorhexidine dental gel in the
mentally retarded
T2 - COMMUNITY DENT. ORAL EPIDEMIOL.
TI - Effects on plaque and gingivitis of a chlorhexidine dental gel in the
mentally retarded
VL - 5
ID - 14576
ER -
TY - JOUR
AB - Microbial cellulose has proven to be a remarkably versatile biomaterial and
can be used in wide variety of applied scientific endeavors, such as paper
products, electronics, acoustics, and biomedical devices. In fact, biomedical
devices recently have gained a significant amount of attention because of an
increased interest in tissue-engineered products for both wound care and the
regeneration of damaged or diseased organs. Due to its unique nanostructure and
properties, microbial cellulose is a natural candidate for numerous medical and
tissue-engineered applications. For example, a microbial cellulose membrane has
been successfully used as a wound-healing device for severely damaged skin and as a
small-diameter blood vessel replacement. The nonwoven ribbons of microbial
cellulose microfibrils closely resemble the structure of native extracellullar
matrices, suggesting that it could function as a scaffold for the production of
many tissue-engineered constructs. In addition, microbial cellulose membranes,
having a unique nanostructure, could have many other uses in wound healing and
regenerative medicine, such as guided tissue regeneration (GTR), periodontal
treatments, or as a replacement for dura mater (a membrane that surrounds brain
tissue). In effect, microbial cellulose could function as a scaffold material for
the regeneration of a wide variety of tissues, showing that it could eventually
become an excellent platform technology for medicine. If microbial cellulose can be
successfully mass produced, it will eventually become a vital biomaterial and will
be used in the creation of a wide variety of medical devices and consumer products.
© 2007 American Chemical Society.
AN - rayyan-563560754
AU - Czaja, W. K.
AU - Young, D. J.
AU - Kawecki, M.
AU - Brown Jr, R. M.
DO - 10.1021/bm060620d
IS - 1
KW - 2 acrylamide 2 methylpropane sulfonic acid
alcohol
alginic acid
antibiotic agent
cellulose
chitosan
polyethylene terephthalate
gelatin
methanol
microbial cellulose
polyethylene
polyglycolic acid
polymer
poviargol
superoxide dismutase
unclassified drug
Acetobacter
biocompatibility
bioengineering
biomedicine
blood vessel diameter
burn
chemical structure
dura mater
fiber
Gluconacetobacter xylinus
human
hydrocolloid
hydrogel
medical device
periodontics
physical chemistry
priority journal
review
skin injury
structure analysis
tissue engineering
tissue regeneration
wound care
wound dressing
Alloderm
Apligraf
Biobrane
Biofill
Dermagraft
Epicel
Integra
TransCyte
XCell
LA - English
PY - 2007
SN - 1525-7797
SP - 1-12
ST - The future prospects of microbial cellulose in biomedical applications
T2 - Biomacromolecules
TI - The future prospects of microbial cellulose in biomedical applications
VL - 8
ID - 14128
ER -
TY - JOUR
AB - The aim of this study was to evaluate the physical properties, chemical
structure and bioactivity of sol-gel processed oxide (SiO2-CaO-P 2O5) composites
used as controlled release materials for Metronidazole - drug applied in
periodontal disease treatment. The obtained composite materials were characterized
by Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD),
the Brunauer-Emmet-Teller (BET) technique and further monitoring in the ultraviolet
and visible light regions (UV-Vis) of the in vitro release of the drug over time.
Using tetramethoxysilane (TMOS) as a precursor of silica matrix and calcium nitrate
tetrahydrate (Ca(NO3)2 4H2O), triethyl phosphite (P(OC2H5)3) as precursors of CaO
and P2O5 respectively, xerogels with different morphology and physical properties
were obtained. The applied modifications improved also the bioactivity and changed
the profile of the drug release. Based on the presented results of this study, it
may be concluded that applied xerogel matrices could be promising candidates for
the formulation in local delivery systems. © 2012 Informa Healthcare USA, Inc.
AN - rayyan-563560520
AU - Czarnobaj, K.
AU - Sawicki, W.
DO - 10.3109/10837450.2011.572894
IS - 6
KW - calcium derivative
calcium nitrate tetrahydrate
calcium oxide
metronidazole
phosphorus derivative
phosphorus pentoxide
silicon dioxide
tetramethoxysilane
triethyl phosphite
unclassified drug
analysis
article
Brunauer Emmet Teller technique
gel
priority journal
X ray powder diffraction
LA - English
PY - 2012
SN - ["1083-7450", "1097-9867"]
SP - 697-704
ST - The sol-gel prepared SiO2-CaO-P2O5 composites doped with Metronidazole for
application in local delivery systems
T2 - Pharm. Dev. Technol.
TI - The sol-gel prepared SiO2-CaO-P2O5 composites doped with Metronidazole for
application in local delivery systems
VL - 17
ID - 13894
ER -
TY - JOUR
AB - Background and Aim: The aim of this study was to evaluate the effects on
bacterial and fibroblasts cells provided by two different LED devices (630 nm ± 10)
used for photodynamic therapy. A handpiece with a single LED (TL-01) that
irradiates one periodontal site per time was compared with a multi-led device that
allows to irradiate all the vestibular sites of a single arch at the same time.
Methods: E. faecalis ATCC 29212 bacterial suspensions (OD600 = 0.12, 10^8 Colony
Forming Units (CFU)/mL) and 6000 human gingival fibroblasts (HGFs) were
distinguished in three test groups and treated according to the following scheme:
TL-01N and TL-03N (N = near), and TL-03F (F = far). Test groups were incubated for
45 minutes with a gel containing 5% of deltaaminolevulinic acid and then irradiated
by two devices for 15 minutes. TL-01 was characterized by a single emitter, surface
irradiance of 380 mJ/cm2 and put a distance of 0.5 mm from the samples. TL-03 had a
multiple emitter with 32° Power LED with 30 mW of power, surface irradiance of 6
mJ/cm2 and the distance of irradiation was 35 mm. Controls were unexposed and
untreated cells. The samples were tested for (i) CFU/mL for the quantification of
cultivable bacterial cells (ii) fibroblasts viability and morphology. The
significance threshold was set at 0.05. Results: Both TL-01 and TL-03 demonstrated
a significant reduction of E. faecalis bacterial load. TL-01 was characterized by
the higher antibacterial activity, but no significant differences were found
respect to TL-03 regardless of the distance of the light source. The viability and
morphology assay showed that TL-01 and TL-03 were fully biocompatible and exerted
similar effects on HGFs by promoting their proliferation. Conclusions: Both tested
devices had similar effects to significantly reducing E. faecalis load and to
stimulating HGFs proliferation in vitro and represent a promising new method as
nonsurgical oral cavity treatment.
AN - rayyan-563559843
AU - D'Ercole, S.
AU - Pierfelice, T. V.
AU - D'Amico, E.
AU - Di Lodovico, S.
AU - Piattelli, A.
AU - Cellini, L.
AU - Iezzi, G.
AU - Petrini, M.
DO - 10.1111/jcpe.13634
KW - aminolevulinic acid
bacterial cell
bacterial load
cell proliferation
cell viability
colony forming unit
conference abstract
controlled study
fibroblast
gingiva
human
in vitro study
irradiation
light
mouth cavity
nonhuman
suspension
LA - English
PY - 2022
SN - 1600-051X
SP - 53
ST - Comparison of two different LED devices for photodynamic therapy in
combination with aminolevulinic acid
TI - Comparison of two different LED devices for photodynamic therapy in
combination with aminolevulinic acid
VL - 49
ID - 13217
ER -
TY - JOUR
AB - Microbial penetration inside the implant's internal cavity produces a
bacterial reservoir that is associated with an area of inflamed connective tissue
facing the fixture-abutment junction. The aim of this clinical trial is to evaluate
the effectiveness of a 1% chlorhexidine gel on the internal bacterial contamination
of implants with screw-retained abutments and on the level of AST secreted in peri-
implant crevicular fluid. Twenty-five patients (aged 29 to 58 years) each received
one implant. Three months after the end of the restorative treatment, and
immediately after a clinical and radiographic examination and the abutment removal,
microbiological samples were obtained from the internal part of each fixture and
biochemical samples were collected by peri-implant sulci. The patients were then
divided into two groups: the control (CG; n=10) and test (TG; n=15) groups. The CG
had the abutment screwed into place and the crown cemented without any further
intervention. In contrast, before the abutment placement and screw tightening, the
TG had the internal part of the fixture filled with a 1% Chlorhexidine gel. Three
months later, the same clinical, microbiological and biochemical procedures were
repeated in both groups. Total bacterial count, specific pathogens and AST activity
were detected. The clinical parameters remained stable throughout the study. From
baseline to the 3-month examination, the total bacterial counts underwent a
significant reduction only in the TG. In contrast, the AST activity showed a
significant increase in the CG. The administration of a 1% Chlorhexidine gel
appears to be an effective method for the reduction of bacterial colonization of
the implant cavity and for safeguarding the health status of peri-implant tissue
over a 3-month administration period. Copyright © by Biolife, s.a.s.
AN - rayyan-563560664
AU - D'Ercole, S.
AU - Tetè, S.
AU - Catamo, G.
AU - Sammartino, G.
AU - Femminella, B.
AU - Tripodi, D.
AU - Spoto, G.
DO - 10.1177/039463200902200417
IS - 4
chlorhexidine
adult
article
bacterial count
bacterium contamination
chemical analysis
clinical article
clinical assessment
female
gingivitis
human
longitudinal study
male
medical device
microbiological parameters
priority journal
radiography
tooth crown
tooth implantation
Branemark system
LA - English
PY - 2009
SN - 0394-6320
SP - 1019-1026
ST - Microbiological and biochemical effectiveness of an antiseptic gel on the
bacterial contamination of the inner space of dental implants: A 3-month human
longitudinal study
T2 - Int. J. Immunopathol. Pharmacol.
TI - Microbiological and biochemical effectiveness of an antiseptic gel on the
bacterial contamination of the inner space of dental implants: A 3-month human
longitudinal study
VL - 22
ID - 14038
ER -
TY - JOUR
AB - Microbial penetration inside the implant's internal cavity produces a
bacterial reservoir that is associated with an area of inflamed connective tissue
facing the fixture-abutment junction. The aim of this clinical trial is to evaluate
the effectiveness of a 1% chlorhexidine gel on the internal bacterial contamination
of implants with screw-retained abutments and on the level of AST secreted in peri-
implant crevicular fluid. Twenty-five patients (aged 29 to 58 years) each received
one implant. Three months after the end of the restorative treatment, and
immediately after a clinical and radiographic examination and the abutment removal,
microbiological samples were obtained from the internal part of each fixture and
biochemical samples were collected by peri-implant sulci. The patients were then
divided into two groups: the control (CG; n=10) and test (TG; n=15) groups. The CG
had the abutment screwed into place and the crown cemented without any further
intervention. In contrast, before the abutment placement and screw tightening, the
TG had the internal part of the fixture filled with a 1% chlorhexidine gel. Three
months later, the same clinical, microbiological and biochemical procedures were
repeated in both groups. Total bacterial count, specific pathogens and AST activity
were detected. The clinical parameters remained stable throughout the study. From
baseline to the 3-month examination, the total bacterial counts underwent a
significant reduction only in the TG. In contrast, the AST activity showed a
significant increase in the CG. The administration of a 1% chlorhexidine gel
appears to be an effective method for the reduction of bacterial colonization of
the implant cavity and for safeguarding the health status of peri-implant tissue
over a 3-month administration period.
AN - rayyan-563562536
AU - D'Ercole, S.
AU - Tete, S.
AU - Catamo, G.
AU - Sammartino, G.
AU - Femminella, B.
AU - Tripodi, D.
AU - Spoto, G.
DO - 10.1177/039463200902200417
IS - 4
PY - 2009
SN - ["0394-6320", "2058-7384"]
SP - 1019-1026
ST - MICROBIOLOGICAL AND BIOCHEMICAL EFFECTIVENESS OF AN ANTISEPTIC GEL ON THE
BACTERIAL CONTAMINATION OF THE INNER SPACE OF DENTAL IMPLANTS: A 3-MONTH HUMAN
LONGITUDINAL STUDY
T2 - INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
TI - MICROBIOLOGICAL AND BIOCHEMICAL EFFECTIVENESS OF AN ANTISEPTIC GEL ON THE
BACTERIAL CONTAMINATION OF THE INNER SPACE OF DENTAL IMPLANTS: A 3-MONTH HUMAN
LONGITUDINAL STUDY
VL - 22
Y2 - 10
ID - 15910
ER -
TY - JOUR
AB - In order to complement non-surgical therapy in periodontitis, there are
multiple options of antimicrobials, such as metronidazole, chlorhexidine,
minocycline, doxycycline and tetracycline, which can be locally delivered into the
mucosa. These drugs are used in periodontal pockets and can inhibit or eliminate
periodontopathogenic microorganisms as well as modulate the inflammatory response
of tissues. However, limited data are available concerning the relationship between
effect, efficacy and clinical status of the periodontium. This review aims to
evaluate the effect and the efficacy of five types of local drug delivery systems
in clinical parameters of periodontology. Researched papers using MEDLINE via
PubMed, and LILACS databases related to five types of local drug delivery systems
as chlorhexidine gluconate, doxycycline hyclate, metronidazole gel, minocycline
ointment and tetracycline fibers, were reviewed aiming to address the mechanism of
action and the evidence of clinical effectiveness of adjunctive use of these
antimicrobials following surgical and/or non-surgical therapies. Inclusion criteria
defined that articles must be randomized controlled trials performed in humans and
published between 1996 and 2014. The adjunctive use of local drug delivery systems
with controlled release properties may provide a defined, but limited, beneficial
response on periodontal pockets. Furthermore, local drug delivery as an active
treatment or maintenance therapy depends on clinical findings, responses to
treatment described in the literature, desired clinical outcomes, and patients'
dental and medical histories, including their past usage of antimicrobials.
AN - rayyan-563560378
AU - Da Rocha, H. A.
AU - Silva, C. F.
AU - Santiago, F. L.
AU - Martins, L. G.
AU - Dias, P. C.
AU - De Magalhães, D.
IS - 3
dental debridement
human
periodontitis
LA - English
PY - 2015
SN - 1466-2094
SP - 82-90
ST - Local Drug Delivery Systems in the Treatment of Periodontitis: A Literature
Review
TI - Local Drug Delivery Systems in the Treatment of Periodontitis: A Literature
Review
VL - 17
ID - 13752
ER -
TY - JOUR
AB - The aim of the present study was to evaluate and compare postoperative pain
after foraminal instrumentation using 5.25% sodium hypochlorite (NaOCl) or 2%
chlorhexidine (CHX) gel irrigation protocol in nonvital single-rooted teeth after
reciprocating instrumentation. Sixty-two volunteers presenting a single root canal
diagnosed with asymptomatic necrosis and apical periodontitis were randomized into
2 experimental groups regarding the irrigation protocol (ie, 5.25% NaOCl and 2% CHX
gel groups). Endodontic treatment was performed in a single session under
reciprocating instrumentation with foraminal instrumentation. Volunteers were
instructed to record pain intensity. Scores from 1 to 4 were attributed to each
kind of pain after 24, 48, and 72 h. Kolmogorov-Smirnov and Student´s t tests were
used to determine significant differences at p<0.05. On average, the percentage of
patients that had no or mild pain after 24, 48 or 72 h was 77.4%, 88.7% and 95.1%,
respectively. No statistically significant age difference was found between the
groups (p>0.05, Student´s t test). Postoperative pain showed no statistically
significant difference at any observation period when using 5.25% NaOCl or 2% CHX
gel (p>0.05). Moreover, no significant difference was observed in the mean number
of analgesic tablets used between the groups (p>0.05). In conclusion, the use of
5.25% NaOCl or 2% CHX gel resulted in the same postoperative pain. Therefore, it
can be inferred that irrigant choice has no relation with short-term follow up
regarding postoperative pain.
AN - rayyan-563560385
AU - da Silva, E. J.
AU - Monteiro, M. R.
AU - Belladonna, F. G.
AU - Almeida, J. F.
AU - De-Deus, G.
AU - Neves, Ad eA
DO - 10.1590/0103-6440201300311
IS - 3
chlorhexidine
hypochlorite sodium
dental device
female
human
male
postoperative pain
LA - English
PY - 2015
SN - 1806-4760
SP - 216-221
ST - Postoperative pain after foraminal instrumentation with a reciprocating
system and different irrigating solutions
T2 - Braz Dent J
TI - Postoperative pain after foraminal instrumentation with a reciprocating
system and different irrigating solutions
VL - 26
ID - 13759
ER -
TY - JOUR
AB - INTRODUCTION: This retrospective cohort study aimed to estimate the success
rate (SR) of primary root canal treatment on teeth with a diagnosis of pulp
necrosis (PN) and asymptomatic apical periodontitis (AAP) when using 2%
chlorhexidine gel as an auxiliary chemical substance and foraminal enlargement
instrumentation technique. METHODS: This study evaluated 178 patients with 206
teeth submitted to primary root canal treatment performed by graduate residents in
endodontics. The inclusion criteria were patients who underwent treatment over a
period of 1-7 years on teeth with a diagnosis of PN and AAP. The SR was evaluated
clinically and radiographically and categorized considering strict (complete
resolution of the periradicular lesion) or loose (reduction in the size of the
existing periradicular lesion) criteria. Cases of clinical and/or radiographic
absence of repair were classified as a failure. Two calibrated examiners
independently assessed treatment outcomes using ImageJ software (National
Institutes of Health, Bethesda, MD). RESULTS: The SRs were 81.1% (95% confidence
interval, 75.7%-86.4%) and 87.4% (95% confidence interval, 82.8%-91.9%) when
considering the strict or loose criteria, respectively. Females had a higher SR
when strict criteria were applied. Also, the SR was significantly reduced when
there was an increase in the patient's age. CONCLUSIONS: Teeth with a diagnosis of
PN and AAP and treated with 2% chlorhexidine gel and foraminal enlargement achieved
substantial SR. Sex and age were prognostic factors that played a significant role
in the SR. Future randomized controlled trials should further investigate the
effects of foraminal enlargement and 2% chlorhexidine gel as an auxiliary chemical
substance.
AN - rayyan-563559692
AU - da Silva, T. A.
AU - de Araújo, L. P.
AU - Gobbo, L. B.
DO - 10.1016/j.joen.2023.06.005
IS - 8
KW - chlorhexidine
dental pulp cavity
female
human
retrospective study
tooth pulp disease
treatment outcome
LA - English
PY - 2023
SN - 1878-3554
SP - 972-979
ST - Outcome of Root Canal Treatment of Teeth with Asymptomatic Apical
Periodontitis Treated with Foraminal Enlargement and 2% Chlorhexidine Gel: A
Retrospective Cohort Study
T2 - J Endod
TI - Outcome of Root Canal Treatment of Teeth with Asymptomatic Apical
Periodontitis Treated with Foraminal Enlargement and 2% Chlorhexidine Gel: A
Retrospective Cohort Study
VL - 49
ID - 13066
ER -
TY - JOUR
AB - Smart gel periodontal drug delivery systems (SGPDDS) containing gellan gum
(0.10.8% w/v), lutrol F127 (14, 16, and 18% w/v), and ornidazole (1% w/v) were
designed for the treatment of periodontal diseases. Each formulation was
characterized in terms of in vitro gelling capacity, viscosity, rheology, content
uniformity, in vitro drug release, and syringeability. In vitro gelation time and
the nature of the gel formed in simulated saliva for prepared formulations showed
polymeric concentration dependency. Drug release data from all formulations was
fitted to different kinetic models and the Korsemeyer-Peppas model was the best fit
model. Drug release was significantly decreased as the concentration of each
polymer component was increased. Increasing the concentration of each polymeric
component significantly increased viscosity, syringeability, and time for 50%, 70%,
and 90% drug release. In conclusion, the formulations described offer a wide range
of physical and drug release characteristics. The formulation containing 0.8% w/v
of gellan gum and 16% w/v of lutrol F127 exhibited superior physical
characteristics. © 2010 Informa Healthcare USA, Inc.
AN - rayyan-563560627
AU - Dabhi, M. R.
AU - Nagori, S. A.
AU - Gohel, M. C.
AU - Parikh, R. K.
AU - Sheth, N. R.
DO - 10.3109/10717544.2010.490247
IS - 7
KW - gellan
ornidazole
poloxamer
article
drug release
flow kinetics
gelation
priority journal
smart gel periodontal drug delivery system
viscosity
LA - English
PY - 2010
SN - ["1071-7544", "1521-0464"]
SP - 520-531
ST - Formulation development of smart gel periodontal drug delivery system for
local delivery of chemotherapeutic agents with application of experimental design
T2 - Drug Deliv.
TI - Formulation development of smart gel periodontal drug delivery system for
local delivery of chemotherapeutic agents with application of experimental design
VL - 17
ID - 14001
ER -
TY - JOUR
AB - The objective of the present investigation was to develop and evaluate
physiological environment responsive periodontal drug delivery system (PERPDDS) for
local delivery of metronidazole benzoate. Poly-ε-caprolactone an in situ
precipitating polymer was used in combination with, carbopol 934P, a pH simulative
polymer to develop PERPDDS. The prepared PERPDDS was evaluated for various
parameters such as in vitro gelling capacity, viscosity, rheology, compatibility
study, and in vitro diffusion study. A 32 full factorial design was used to
investigate the influence of formulation variables. Drug release data from all
formulations were fitted to different kinetic models and the korsemeyer-peppas
model was found the best fit model. The value of diffusional exponent (n) was in
between 0.3283 and 0.3979 indicating purely fickian diffusion release mechanism.
Increasing the concentration of each polymeric component increases viscosity, and
time for 50% and 90% drug release was observed and graphically represented by the
surface response and contour plots. © 2013 Informa Healthcare USA, Inc.
AN - rayyan-563560491
AU - Dabhi, M. R.
AU - Sheth, N. R.
DO - 10.3109/03639045.2012.662505
IS - 3
KW - carbopol 934
polycaprolactone
article
biocompatibility
controlled study
drug formulation
drug release
flow kinetics
in vitro study
pH
viscosity
LA - English
PY - 2013
SN - ["0363-9045", "1520-5762"]
SP - 425-436
ST - Formulation development of physiological environment responsive periodontal
drug delivery system for local delviery of metronidazole benzoate
T2 - Drug Dev. Ind. Pharm.
TI - Formulation development of physiological environment responsive periodontal
drug delivery system for local delviery of metronidazole benzoate
VL - 39
ID - 13865
ER -
TY - JOUR
AB - This study was conducted to reveal phenotypic, serological subtypes and
antibiotic susceptibility among fresh isolates of Porphyromonas gingivalis in a
Swedish population with periodontitis and periodontal abscess. Fifty-five
subgingival strains were isolated and tentatively designated as P. gingivalis from
55 consecutive paper-point samples taken from 51 patients with periodontitis (at
least one site with >6-mm pocket depth) in Sweden and were sent in for
microbiological evaluation. Eight P. gingivalis strains from periodontal abscesses
were also included. Four P. gingivalis strains served as reference and another four
type strains were included. The strains were characterized by colony morphology,
biochemical tests, enzyme profile, gas-liquid chromatography and antibiotic
susceptibility. The strains were further characterized for whole cell protein
profiles using sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-
PAGE) and were identified to serotype by specific monoclonal antibodies. Among the
55 P. gingivalis strains 35 had smooth (S), 13 rough (R) and seven semi-rough
colony morphologies. All strains were phenotypically homogeneous in biochemical
tests, enzyme profile and antibiotic susceptibility. All strains produced
phenylacetic acid and α-fucosidase. Almost all (96%) of the subgingival strains,
but relatively fewer (62%) of the abscess strains, belonged to serotype A. Two
subgingival and three abscess strains were classified as serotype B. No specific
SDS-PAGE protein profiles were recorded for the two serotypes. The P. gingivalis
strains from Swedish periodontitis cases showed homogeneity in terms of biochemical
phenotypes and antibiotic susceptibility patterns. The strains fell into two
serotypes, of which serotype A predominated in the periodontitis cases and serotype
B was overrepresented in periodontal abscesses. © 2007 The Authors.
AN - rayyan-563560748
AU - Dahlén, G.
AU - Gmür, R.
AU - Yoshino, T.
DO - 10.1111/j.1399-302X.2007.00324.x
IS - 2
KW - alpha levo fucosidase
amoxicillin
bacterial enzyme
bacterial protein
clindamycin
erythromycin
isoxapenicillin
kanamycin
metronidazole
monoclonal antibody
oxytetracycline
penicillin G
phenylacetic acid
tetracycline
tinidazole
unclassified drug
article
bacterial cell
bacterial strain
bacterium colony
bacterium isolate
chemical analysis
classification
controlled study
gas liquid chromatography
human
nonhuman
periodontitis
phenotype
serotype
Sweden
LA - English
PY - 2007
SN - ["0902-0055", "1399-302X"]
SP - 80-86
ST - Phenotypes, serotypes and antibiotic susceptibility of Swedish Porphyromonas
gingivalis isolates from periodontitis and periodontal abscesses
T2 - Oral Microbiol. Immunol.
TI - Phenotypes, serotypes and antibiotic susceptibility of Swedish Porphyromonas
gingivalis isolates from periodontitis and periodontal abscesses
VL - 22
ID - 14122
ER -
TY - JOUR
AB - Since its discovery approximately 200 years ago, chitosan, as a cationic
natural polymer, has been widely used as a topical dressing in wound management
owing to its hemostatic, stimulation of healing, antimicrobial, nontoxic,
biocompatible and biodegradable properties. This article covers the antimicrobial
and wound-healing effects of chitosan, as well as its derivatives and complexes,
and its use as a vehicle to deliver biopharmaceuticals, antimicrobials and growth
factors into tissue. Studies covering applications of chitosan in wounds and burns
can be classified into in vitro, animal and clinical studies. Chitosan preparations
are classified into native chitosan, chitosan formulations, complexes and
derivatives with other substances. Chitosan can be used to prevent or treat wound
and burn infections not only because of its intrinsic antimicrobial properties, but
also by virtue of its ability to deliver extrinsic antimicrobial agents to wounds
and burns. It can also be used as a slow-release drug-delivery vehicle for growth
factors to improve wound healing. The large number of publications in this area
suggests that chitosan will continue to be an important agent in the management of
wounds and burns. © 2011 Expert Reviews Ltd.
AN - rayyan-563560584
AU - Dai, T.
AU - Tanaka, M.
AU - Huang, Y. Y.
AU - Hamblin, M. R.
DO - 10.1586/eri.11.59
IS - 7
KW - 5 methylpyrrolidinone chitosan
adhesive agent
alginic acid
amikacin
antiinfective agent
arginine
benzydamine
biomaterial
chitin
chitosan
chitosan derivative
chitosan oligomer
daptomycin
gentamicin
growth factor
hyaluronic acid
macrogol
metronidazole
n acetylglucosamine
n carboxybutyl oligomer
nanoparticle
oligomer
oligosaccharide
polyphenol
recombinant thromboplastin
sulfadiazine silver
teichoic acid
triclosan
unclassified drug
unindexed drug
vancomycin
anterior cruciate ligament
biocompatibility
biodegradability
biodegradation
burn infection
cornea injury
drug effect
epithelization
hemorrhagic cystitis
host parasite interaction
human
hydrogel
in vitro study
liver disease
macrophage
neutrophil
nonhuman
occlusive dressing
osteoblast
osteomyelitis
physical chemistry
review
skin incision
skin infection
slow release formulation
spinal cord injury
stomatitis
surgical infection
tissue engineering
tissue repair
treatment response
urogenital tract disease
wound
wound dressing
wound healing
wound infection
LA - English
PY - 2011
SN - ["1478-7210", "1744-8336"]
SP - 857-879
ST - Chitosan preparations for wounds and burns: Antimicrobial and wound-healing
effects
T2 - Expert Rev. Anti-Infect. Ther.
TI - Chitosan preparations for wounds and burns: Antimicrobial and wound-healing
effects
VL - 9
ID - 13958
ER -
TY - JOUR
AB - Nanogels have piqued the interest of researchers as nanoscopic drug delivery
systems, especially for site-specific or time-controlled delivery of therapeutic
mediators. A wide range of polymer systems and the fundamental alteration of their
physicochemical properties have resulted in multipurpose nanogel formulations.
Nanogels have high longevity, drug-loading capability, biologic stability, high
permeability, and react to external stimuli. Nanogels have shown great promise in
various areas, including gene distribution, chemotherapeutic agents transmission,
monitoring, and organ targeting, among others. Spheroids as in vitro tumor models
were used to screen drug-loaded nanogels against in vitro cancer cells. Spheroids
can represent in vivo tumor mass, reducing prices, time to results, and
political/ethical considerations before clinical practice. This review focuses on
different types of nanogels, preparation methods, and the main mechanisms of drug
release from nanogels. Mainly, the recent applications of nanogels as drug delivery
systems in multicellular spheroid tumor models are discussed.
AN - rayyan-563559903
AU - Dalir Abdolahinia, E.
AU - Barati, G.
AU - Ranjbar-Navazi, Z.
AU - Kadkhoda, J.
AU - Islami, M.
AU - Hashemzadeh, N.
AU - Sharifi, S.
DO - 10.1016/j.jddst.2022.103109
KW - alginic acid
antiinfective agent
collagenase
copolymer
hyaluronic acid
iron oxide nanoparticle
macrogol
molecular scaffold
nanogel
polymer
polypeptide
polysaccharide
sulfanilamide
biodegradation
cancer cell
cell adhesion
clinical evaluation
drug mechanism
drug release
embryoid body
human
hydrogen bond
light
liquid
magnetic field
microtechnology
multicellular spheroid
nonhuman
oxidation reduction state
pH
physical chemistry
review
temperature
tumor model
tumor spheroid
LA - English
PY - 2022
SN - 1773-2247
ST - Application of nanogels as drug delivery systems in multicellular spheroid
tumor model
TI - Application of nanogels as drug delivery systems in multicellular spheroid
tumor model
VL - 68
ID - 13277
ER -
TY - JOUR
AB - Root conditioners are used to promote root surface biomodification to
increase the success rate of root coverage. Citric acid and tetracycline are
commonly used. There is recent indication for using antimicrobial photodynamic
therapy (aPDT) with this purpose. The aim of this study is to evaluate the effects
of citric acid/tetracycline gel and aPDT in root coverage of gingival recessions
using subepithelial connective tissue graft. This parallel, double-blinded clinical
trial enrolled 17 patients (60 recession defects; 20/group). Experimental groups
were: Control group (SRP) - scaling and root planing only; Citric acid/tetracycline
gel (CAT) group - SRP plus citric acid/tetracycline gel; aPDT - SRP, toluidine blue
O (100 μl/ml) and red laser. At baseline and after 3, 6 and 12 months, the clinical
parameters were evaluated: recession depth (RD), percentage of root coverage (%RC),
keratinized tissue width (KTW), soft tissue thickness (STT), probing depth (PD),
clinical attachment level (CAL), dentin hypersensitivity (HYPER) and esthetic
perception by patient (EST). CAT group presented reduction in PD, CAL, RD, increase
in KTW and STT, higher %RC (81.6%) and better esthetic in relation to SRP group
(p < .05). aPDT treatment promoted CAL reduction, gain of KTW and STT and higher %RC
(82.1%) in relation to SRP (57.7%) (p < .05). There was a reduction in dentin
sensitivity in all groups. Complete root coverage was higher for CAT group (65%)
and aPDT group (70%) in relation to SRP (30%) (p < .05). Root conditioning, with
citric acid/tetracycline gel and aPDT, promotes better long-term clinical outcomes
and root coverage after SCTG procedures.
AN - rayyan-563561313
AU - Damante, C. A.
AU - Karam, Psbh
AU - Ferreira, R.
AU - Rezende, M. L. R.
AU - Greghi, S. L. A.
AU - Sant'Ana, A. C. P.
AU - Zangrando, M. S. R.
DO - 10.1016/j.jphotobiol.2019.111528
J2 - J Photochem Photobiol B
KW - Adult
Anti-Infective Agents/chemistry/therapeutic use
Citric Acid/*chemistry
Dentin Sensitivity/pathology
Double-Blind Method
Female
Gels/chemistry
Gingiva/pathology/*transplantation
Gingival Recession/pathology/*therapy
Guided Tissue Regeneration, Periodontal
Humans
*Lasers
Male
Middle Aged
Photochemotherapy
Root Planing
Tetracycline/*chemistry/therapeutic use
Tooth Root/surgery
Treatment Outcome
Young Adult
LA - eng
N1 - Department of Prosthodontics and Periodontics, Bauru School of Dentistry,
University of São Paulo, Brazil. Electronic address: cdamante@usp.br.; Department
of Prosthodontics and Periodontics, Bauru School of Dentistry, University of São
Paulo, Brazil.; Department of Prosthodontics and Periodontics, Bauru School of
Dentistry, University of São Paulo, Brazil.; Department of Prosthodontics and
Periodontics, Bauru School of Dentistry, University of São Paulo, Brazil.;
Department of Prosthodontics and Periodontics, Bauru School of Dentistry,
University of São Paulo, Brazil.; Department of Prosthodontics and Periodontics,
Bauru School of Dentistry, University of São Paulo, Brazil.; Department of
Prosthodontics and Periodontics, Bauru School of Dentistry, University of São
Paulo, Brazil.
PY - 2019
SP - 111528
ST - Root surface demineralization by citric acid/tetracycline gel and aPDT
associated to subepithelial connective tissue graft improves root coverage
outcomes. A 12-month preliminary randomized clinical trial
T2 - Journal of photochemistry and photobiology. B, Biology
TI - Root surface demineralization by citric acid/tetracycline gel and aPDT
associated to subepithelial connective tissue graft improves root coverage
outcomes. A 12-month preliminary randomized clinical trial
VL - 197
Y2 - 8
ID - 14687
ER -
TY - JOUR
AB - The aim of this study was to evaluate the effects of chlorhexidine and
calcium hydroxide on apical periodontitis in rats. Experimentally induced apical
periodontitis was established on the mesial roots of maxillary molars of Wistar
rats by leaving the root canals exposed to the oral cavity for 14 d. In the
positive control group (n = 10 teeth), the root canals were not further treated,
but the coronal access openings were filled with composite. In the negative control
group (n = 10 teeth), partial pulpotomies were performed aseptically and the
coronal access openings were sealed immediately. In a third control group (n = 10
teeth) the canals were instrumented, left empty, and the coronal access openings
were sealed. In the experimental groups, the root canals were instrumented and
filled with either 2% chlorhexidine gel or calcium hydroxide paste (n = 10 teeth
per group). After 7 d all rats were killed and the histological sections were
stained for microscopic analysis of periapical regeneration. The data of the
subjective evaluation were analyzed with the Kruskal-Wallis test. Lesion sizes were
measured and statistically analyzed using the ANOVA and post-hoc Scheffé test. The
two treatment groups showed significantly lower average inflammatory scores and
smaller lesion sizes than the positive and third control group (p < 0.05). No
statistically significant differences were obtained between the two treatment
groups (p > 0.05). Chlorhexidine used as an intracanal medicament showed good
periapical regeneration, suggesting that this may be an alternative to calcium
hydroxide root canal dressing. © 2005 Taylor & Francis.
AN - rayyan-563560841
AU - Dammaschke, T.
AU - Schneider, U.
AU - Stratmann, U.
AU - Yoo, J. M.
AU - Schäfer, E.
DO - 10.1080/00016350510019801
IS - 3
KW - calcium hydroxide
chlorhexidine
animal cell
animal experiment
animal model
animal tissue
article
controlled study
endodontics
evaluation study
female
histopathology
inflammation
male
microscopic anatomy
molar tooth
nonhuman
periodontal disease
rat
regeneration
tooth root canal
LA - English
PY - 2005
SN - 0001-6357
SP - 143-152
ST - Effect of root canal dressings on the regeneration of inflamed periapical
tissue
T2 - Acta Odontol. Scand.
TI - Effect of root canal dressings on the regeneration of inflamed periapical
tissue
VL - 63
ID - 14215
ER -
TY - JOUR
AB - The treatment of drug-induced gingival overgrowth is compounded by the high
recurrence rate resulting from chronic use of the medication and the persistence of
other risk factors. In this case series, the treatment outcome of a nonsurgical
periodontal therapy, according to the concept of full-mouth disinfection in 11
patients with drug-induced gingival overgrowth, is described. All clinical
parameters improved significantly after therapy. Only 6% of teeth received further
surgical treatment. The clinical situation remained stable during the recall. The
present case series suggests that full-mouth disinfection might be a beneficial
treatment concept for drug-induced gingival overgrowth, reducing the need for
further surgical intervention.
AN - rayyan-563560651
AU - Dannewitz, B.
AU - Krieger, J. K.
AU - Simon, I.
AU - Dreyhaupt, J.
AU - Staehle, H. J.
AU - Eickholz, P.
IS - 1
KW - calcium channel blocking agent
chlorhexidine
cyclosporine
immunosuppressive agent
mouthwash
toothpaste
adult
aged
article
case report
female
gel
gingiva overgrowth
human
male
middle aged
retrospective study
treatment outcome
LA - English
PY - 2010
SN - 0198-7569
SP - 63-71
ST - Full-mouth disinfection as a nonsurgical treatment approach for drug-induced
gingival overgrowth: a series of 11 cases
TI - Full-mouth disinfection as a nonsurgical treatment approach for drug-induced
gingival overgrowth: a series of 11 cases
VL - 30
ID - 14025
ER -
TY - JOUR
AB - Objectives: Evaluation of the clinical effect of topical subgingival
application of doxycycline gel adjunctively to scaling and root planing (SRP) at
furcation sites during supportive periodontal therapy (SPT). Material and Methods:
In 39 SPT patients exhibiting at least four pockets ≥5 mm with bleeding on probing,
SRP was rendered in all pockets ≥4 mm. Additionally, 14% doxycycline gel was
applied subgingivally in 20 patients after random assignment (SRP&DOXY). Clinical
parameters were assessed at baseline, 3, 6, and 12 months after therapy. Additional
benefit of topical doxycycline was evaluated as a short-term (3 months) improvement
of furcation involvement and influence on the frequency of re-instrumentation up to
12 months. Results: A total of 323 furcation sites (class 0: 160; class I: 101;
class II: 18; and class III: 44) were treated (SRP: 165, SRP&DOXY: 158). SRP&DOXY
resulted in better improvement of furcation involvement than SRP alone 3 months
after treatment (p=0.041). However, SRP&DOXY failed to show a significant
difference between both groups in the number of re-instrumentations. Conclusion:
Single subgingival application of doxycycline in addition to SRP had a short-term
effect on furcation involvement. However, it failed to reduce the frequency of re-
instrumentation up to 12 months at furcation sites. © 2009 John Wiley & Sons AS.
Journal compilation © 2009 John Wiley & Sons AS.
AN - rayyan-563560676
AU - Dannewitz, B.
AU - Lippert, K.
AU - Lang, N. P.
AU - Tonetti, M. S.
AU - Eickholz, P.
DO - 10.1111/j.1600-051X.2009.01414.x
IS - 6
doxycycline
article
clinical trial
comparative study
controlled study
female
follow up
gel
gingiva
gingiva bleeding
gingiva disease
human
male
middle aged
molar tooth
pathology
periodontal disease
periodontitis
premolar tooth
retreatment
tooth plaque
treatment outcome
LA - English
PY - 2009
SN - ["0303-6979", "1600-051X"]
SP - 514-522
ST - Supportive periodontal therapy of furcation sites: Non-surgical
instrumentation with or without topical doxycycline
TI - Supportive periodontal therapy of furcation sites: Non-surgical
instrumentation with or without topical doxycycline
VL - 36
ID - 14050
ER -
TY - JOUR
AB - Aim: Root conditioning is aimed at smear layer removal and at dental matrix
collagen exposure, which may promote periodontal regeneration. This in vitro study
assessed smear layer removal, collagen fiber exposure and the influence of PRP
(platelet-rich plasma) application on adhesion of blood cells to the root surface
using scanning electron microscopy (SEM). Materials and methods: Scaled root
samples (n = 160) were set in five groups and conditioned with: group I - control
group (saline solution); group II (EDTA 24%); group III (citric acid 25%); group IV
(tetracycline hydrochloride 50 mg/ml); group V (sodium citrate 30%). Eighty samples
were assessed using the root surface modification index (RSMI). The other eighty
samples were set in two groups. The first group (n = 40) received PRP gel
application with a soft brush and the second group (n = 40) received PRP
application and then a blood drop. The fibrin clot formation was assessed in the
first group and the blood cells adhesion was assessed in the second group using the
BEAI (blood elements adhesion index). A previously trained, calibrated, and blind
examiner evaluated photomicrographs. Statistical analysis was performed using the
Kruskal-Wallis's and Dunn's tests. Results: Group III attained the best results for
RSMI and BEAI. Moreover, it was the only group showing fibrin clot formation.
Conclusion: Citric acid was the most efficient conditioner for smear layer removal,
collagen fiber exposure and blood cell adhesion. Moreover, it was the only group
showing fibrin clot formation after PRP application. Clinical significance: This
study demonstrated that root conditioning followed by PRP application may favor
blood cell adhesion on root surface which may optimize periodontal healing.
AN - rayyan-563560549
AU - Dantas, A. A. R.
AU - Fontanari, L. A.
AU - de Paula Ishi, E.
AU - Leite, F. R. M.
AU - Zandim, D. L.
AU - Rached, R. S. G. A.
AU - Sampaio, J. E. C.
DO - 10.5005/jp-journals-10024-1147
IS - 3
KW - chelating agent
citrate sodium
citric acid
edetic acid
fibrin
tetracycline
article
blood cell
blood clotting
cell adhesion
tooth cementum
dental surgery
dentin
drug effect
human
male
physiology
tooth disease
tooth root
ultrastructure
LA - English
PY - 2012
SN - 1526-3711
SP - 332-338
ST - Blood cells attachment after root conditioning and PRP application: An in
vitro study
TI - Blood cells attachment after root conditioning and PRP application: An in
vitro study
VL - 13
ID - 13923
ER -
TY - JOUR
AB - Class II mandibular furcation defect is a periodontal condition characterized
by a cul-de-sac lesion, a definite parallel constituent with only a portion of
alveolar bone remaining intact. There may be involvement of vertical bone loss.
Local drug deliveries such as Boric acid, alendronate gel, and other drugs
exhibited anti-inflammatory, antibacterial & osteoblastic differentiation activity.
The present systematic review compares the drugs based on their outcomes and
pharmacological action. To analzse & compare various forms of local drug delivery
systems on a class II furcation. A search was conducted using PubMed, Google
scholar, science direct, and Pub Med central using MeSH terms - local drug delivery
in periodontics, boric acid in the management of class II mandibular furcation,
simvastatin in the treatment of furcation. A total of 560 articles were screened;
58 out of 560 were full-text articles accessed for eligibility, and five articles
were included in the systematic review. PRISMA guidelines were used for reporting
this review. In addition, five randomized controlled trials were enclosed and used
in this systematic review. The various local drugs used in treating class II
mandibular furcation defects are effective in the prevention of bleeding on
probing, bone resorption, gingival bleeding index and increase in the bone fill,
and microbial deposit removal. The managing of class II mandibular furcation defect
with the drugs mentioned in this review can be effective by reducing several
clinical parameters such as bleeding on probing, gingival indices, osteoblastic
differentiation, bone fill, etc., Considering the results of the studies, it can be
concluded that it can be used as a therapeutic therapy against class II furcation
defects with positive outcomes.
AN - rayyan-563561456
AU - Das, R. K.
AU - Bharathwaj, V. V.
AU - Sindhu, R.
AU - Prabu, D.
AU - Rajmohan, M.
AU - Dhamodhar, D.
AU - Sathiyapriya, S.
DO - 10.4103/jpbs.jpbs_572_22
J2 - J Pharm Bioallied Sci
LA - eng
N1 - Department of Public Health Dentistry, SRM Dental College and Hospital,
Ramapuram, Chennai, India.; Department of Public Health Dentistry, SRM Dental
College and Hospital, Ramapuram, Chennai, India.; Department of Public Health
Dentistry, SRM Dental College and Hospital, Ramapuram, Chennai, India.; Department
of Public Health Dentistry, SRM Dental College and Hospital, Ramapuram, Chennai,
India.; Department of Public Health Dentistry, SRM Dental College and Hospital,
Ramapuram, Chennai, India.; Department of Public Health Dentistry, SRM Dental
College and Hospital, Ramapuram, Chennai, India.; Department of Public Health
Dentistry, SRM Dental College and Hospital, Ramapuram, Chennai, India.
PY - 2023
SN - 0976-4879 (Print)
SP - S742-S746
ST - Comparative Analysis of Various Forms of Local Drug Delivery Systems on a
Class 2 Furcation - A Systematic Review
T2 - Journal of pharmacy & bioallied sciences
TI - Comparative Analysis of Various Forms of Local Drug Delivery Systems on a
Class 2 Furcation - A Systematic Review
VL - 15
Y2 - 7
ID - 14830
ER -
TY - JOUR
AB - Class II mandibular furcation defect is a periodontal condition characterized
by a cul-de-sac lesion, a definite parallel constituent with only a portion of
alveolar bone remaining intact. There may be involvement of vertical bone loss.
Local drug deliveries such as Boric acid, alendronate gel, and other drugs
exhibited anti-inflammatory, antibacterial & osteoblastic differentiation activity.
The present systematic review compares the drugs based on their outcomes and
pharmacological action. To analzse & compare various forms of local drug delivery
systems on a class II furcation. A search was conducted using PubMed, Google
scholar, science direct, and Pub Med central using MeSH terms-local drug delivery
in periodontics, boric acid in the management of class II mandibular furcation,
simvastatin in the treatment of furcation. A total of 560 articles were screened;
58 out of 560 were full-Text articles accessed for eligibility, and five articles
were included in the systematic review. PRISMA guidelines were used for reporting
this review. In addition, five randomized controlled trials were enclosed and used
in this systematic review. The various local drugs used in treating class II
mandibular furcation defects are effective in the prevention of bleeding on
probing, bone resorption, gingival bleeding index and increase in the bone fill,
and microbial deposit removal. The managing of class II mandibular furcation defect
with the drugs mentioned in this review can be effective by reducing several
clinical parameters such as bleeding on probing, gingival indices, osteoblastic
differentiation, bone fill, etc., Considering the results of the studies, it can be
concluded that it can be used as a therapeutic therapy against class II furcation
defects with positive outcomes.
AN - rayyan-563559699
AU - Das, R.
AU - Bharathwaj, V. V.
AU - Sindhu, R.
AU - Prabu, D.
AU - Rajmohan, M.
AU - Dhamodhar, D.
AU - Sathiyapriya, S.
DO - 10.4103/jpbs.jpbs_572_22
IS - 5
atorvastatin
boric acid
rosuvastatin
simvastatin
tetracycline
article
bleeding on probing
comparative study
female
human
male
osteoblast
osteolysis
periodontal disease
Preferred Reporting Items for Systematic Reviews and Meta-Analyses
systematic review
LA - English
PY - 2023
SN - 0975-7406
SP - 742-746
ST - Comparative analysis of various forms of local drug delivery systems on a
class 2 furcation-A systematic review
T2 - J. Pharm. Bioallied Sci.
TI - Comparative analysis of various forms of local drug delivery systems on a
class 2 furcation-A systematic review
VL - 15
ID - 13073
ER -
TY - JOUR
AB - The novelty of this study consists on the formulation and evaluation of five
complex experimental natural photosensitizers (PS): gel with oregano essential oil
(O), gel with methylene blue (AM), gel with a mixture of essential oils (Thieves-
H), gel with arnica oil and curcuma extract (CU) and gel with frankincense
essential oil (T), used as photosensitizing agents (PS) in antimicrobial
photodynamic therapy (aPDT) in the control of microbial biofilm in oral cavity. The
experimental PS were characterized by gas chromatography-mass spectrometry (GC-MS),
Fourier-transform infrared spectroscopy (FTIR), UV-Vis spectroscopy, cytotoxicity
assay, antimicrobial effect and scanning electron microscopy (SEM). The IR spectra
of the experimental PS with essential oils exhibit absorption bands due to the
presence of water and glycerol in high quantities. The studied compounds had a
reduced cytotoxic effect on cell cultures. The lowest cytotoxic effect was observed
in experimental PS with oregano essential oil and methylene blue PS. Essential oils
with proven antibacterial capabilities used in experimental PS confer antibacterial
activity to the gels in which they are incorporated, an activity that may be more
efficient use of a PDT therapy. Single bacteria were detected mainly by SEM after
12 h, while aggregate bacteria and micro colonies dominated the samples at 48 h.
AN - rayyan-563562297
AU - Dascalu, L. M.
AU - Moldovan, M.
AU - Prodan, D.
AU - Ciotlaus, I.
AU - Popescu, V.
AU - Baldea, I.
AU - Carpa, R.
AU - Sava, S.
AU - Chifor, R.
AU - Badea, M. E.
DO - 10.3390/ma13133012
IS - 13
PY - 2020
SN - 1996-1944
ST - Assessment and Characterization of Some New Photosensitizers for
Antimicrobial Photodynamic Therapy (aPDT)
T2 - MATERIALS
TI - Assessment and Characterization of Some New Photosensitizers for
Antimicrobial Photodynamic Therapy (aPDT)
VL - 13
Y2 - 7
ID - 15671
ER -
TY - JOUR
AB - A number of studies have assessed the effect of chlorhexidine on the
postoperative healing of periodontal wounds. Available data suggest that rinsing
with a 0.2% chlorhexidine gluconate solution does not influence healing while a
conventional dressing is in place, but once this is removed healing is enhanced by
either a chlorhexidine rinse or gel. Dressings incorporating chlorhexidine also
hasten wound healing. Studies undertaken in dogs clearly demonstrate that the
beneficial effect of this agent is due to its ability to remove existing plaque
deposits and prevent new plaque formation.
AN - rayyan-563561203
AU - Davies, R. M.
DO - 10.1111/j.1600-051X.1977.tb00059.x
IS - 5
KW - chlorhexidine
placebo
clinical study
dog
drug therapy
human cell
mouth
mouth hygiene
oral surgery
periodontics
plaque
postoperative care
surgery
therapy
tooth
tooth plaque
wound healing
hibitane
LA - English
PY - 1977
SN - 0303-6979
SP - 129-135
ST - Use of hibitane following periodontal surgery
TI - Use of hibitane following periodontal surgery
VL - 4
ID - 14577
ER -
TY - JOUR
AB - Twelve Beagle dogs were allocated to three equal groups on the basis of
existing plaque scores. Two gels, one containing 0.5% chlorhexidine digluconate,
the other a placebo, were applied once daily to the teeth of separate groups of
animals, the third group serving as controls. The chlorhexidine gel inhibited the
formation of plaque and reduced the severity of gingivitis. In a further study the
distribution of 14C labeled chlorhexidine was determined in the oral and systemic
tissues of dogs after a single or repeated oral dose. Labeled material was observed
in the superficial epithelial layers of all oral tissues; higher levels of activity
were present on keratinized than on nonkeratinized surfaces. This process of
adsorption was apparently reversible and no accumulation of chlorhexidine was
detected in the mouth after repeated dosing. No absorption of labeled material
through the oral tissues was observed.
AN - rayyan-563561216
AU - Davies, R. M.
AU - Hull, P. S.
KW - acepromazine
barbituric acid derivative
chlorhexidine
chlorhexidine c 14
pentobarbital
placebo
unclassified drug
artery
atherosclerotic plaque
autoradiography
dog
drug absorption
drug distribution
drug metabolism
gingivitis
methodology
mouth
mouth mucosa
pharmacokinetics
plaque formation
theoretical study
tooth plaque
nembutal
LA - English
PY - 1973
SN - 0022-3484
SP - 22-27
ST - Plaque inhibition and distribution of chlorhexidine in Beagle dogs
T2 - J. PERIODONTAL RES.
TI - Plaque inhibition and distribution of chlorhexidine in Beagle dogs
ID - 14590
ER -
TY - JOUR
AB - Objectives: The objective of the present work was to evaluate the ultrasonic
agitation, time and vehicle (propylene glycol or distilled water) on the
antimicrobial potential and penetrability of calcium hydroxide pastes on infected
dentin by means of Confocal Laser Scanning Microscopy (CLSM) and microbiological
culture (MC). Materials and methods: Dentin specimens were infected with
Enterococcus faecalis using a new contamination protocol of 5 days. The specimens
were divided into eight groups and dressed with the pastes for 7 or 15 days: G1)
calcium hydroxide (CH) + propylene glycol (prop)/7 days (d), G2) CH + prop/7d +
ultrasonic agitation (U), G3) CH + distilled water (dw)/7d, G4) CH + dw/7d + U, G5)
CH + prop/15d, G6) CH + prop/15d + U, G7) CH + dw/15d, G8) CH + dw/15d + U. The
ultrasonic activation was made for 1 min in both directions with a plain point
insert. After medications removal, the images obtained by CLSM showed the viable
(green) and dead (red) bacteria with Live and Dead dye. By the MC, the dentinal
wall debris obtained by burs were collected for colony counts. For the penetration
test, the Rodamine B dye was added to the CH pastes and analyzed by CLSM. Results:
The 7 and 15-days CH + prop+U pastes performed better antimicrobial efficacy,
followed by the CH + dw+U/15d paste. Conclusions: All pastes demonstrated better
penetration and antimicrobial activity against E. faecalis when agitated with
ultrasound, even in periods of up to seven days. The propylene glycol vehicle
showed better results. Clinical relevance: Agitation of the dressing that remains
for less time inside the root canal can optimize the decontamination of endodontic
treatment. [GRAPHICS] .
AN - rayyan-563562550
AU - de Andrade, F. B.
AU - Vasconcelos, Lrdm
AU - Pereira, T. C.
AU - Garcia, R. B.
AU - Bramante, C. M.
AU - Duarte, M. A. H.
DO - 10.1007/s10856-021-06607-6
IS - 12
PY - 2021
SN - ["0957-4530", "1573-4838"]
ST - Ultrasonic agitation reduces the time of calcium hydroxide antimicrobial
effect and enhances its penetrability
TI - Ultrasonic agitation reduces the time of calcium hydroxide antimicrobial
effect and enhances its penetrability
VL - 32
Y2 - 12
ID - 15924
ER -
TY - JOUR
AB - INTRODUCTION: Peri-implant pathologies consist of an inflammatory process
affecting the soft and hard tissues surrounding the implants. Chlorhexidine is
considered the gold standard antiseptic, with a large variety of choice in
administration. In this study, a protocol for the irrigation of peri-implant
pockets with a chlorhexidine gel, using a plastic needle for the delivery of the
product into the peri-implant pockets is described. STUDY PARTICIPANTS AND METHODS:
Nine patients with at least one implant presenting peri-implant pathology (inflamed
soft tissue associated with bone loss around the implant) were enrolled in this
prospective clinical study, and followed-up for 1 year, where clinical parameters
such as modified plaque index, modified bleeding index, probing pocket depths,
attachment levels were assessed at baseline, 1 month, and 1 year after
implementation of the treatment protocol. RESULTS: Treatment success was achieved
in eight of the nine patients (and in 11 of the 13 implants) according to the
success criteria adopted by the authors of this study. DISCUSSION: Infection
control lies at the heart of peri-implant treatment. The control of three factors
such as optimal diagnosis, removal of the aetiological factor of the disease
(proper removal of debris and decontamination of the peri-implant sulcus/pocket)
and a good patient's oral hygiene self-care represents the key to success,
resulting in good treatment outcomes when managing peri-implant pathologies. The
protocol used (irrigation of peri-implant pockets with chlorhexidine gel delivered
by a plastic needle) is considered to be of utility.
AN - rayyan-563560773
AU - De Araújo Nobre, M.
AU - Capelas, C.
AU - Alves, A.
AU - Almeida, T.
AU - Carvalho, R.
AU - Antunes, E.
AU - Oliveira, D.
AU - Cardador, A.
AU - Maló, P.
DO - 10.1111/j.1601-5037.2006.00173.x
IS - 2
KW - chlorhexidine
aged
article
clinical trial
disposable equipment
female
gel
gingivitis
human
infection
devices
lavage
male
middle aged
needle
osteolysis
periodontics
periodontitis
prospective study
tooth implantation
LA - English
PY - 2006
SN - 1601-5029
SP - 84-90
ST - Non-surgical treatment of peri-implant pathology
T2 - Int J Dent Hyg
TI - Non-surgical treatment of peri-implant pathology
VL - 4
ID - 14147
ER -
TY - JOUR
AB - Lippia sidoides is a typical shrub from Brazil that has been used in
traditional medicine. This is a systematic review on the effect of L. sidoides for
controlling dental plaque, gingivitis, and periodontitis. A database search through
May 2021 in Medline/PubMed, SCOPUS, BVS, and Web of Science identified 711 reports
of which 17 met our inclusion criteria. Five randomized controlled trials and three
animal studies were included that compared L. sidoides -based products (toothpaste,
mouthrinse, and gel) to cetylpyridinium chloride, chlorhexidine, and placebo
products. Among the human studies, a significant antiplaque effect after treatment
with L. sidoides -based products was observed in three studies and an
antigingivitis effect in two studies, similar to chlorhexidine-based products. One
study found superior dental plaque reduction compared to cetylpyridinium chloride
mouthrinse. Only one study testing a L. sidoides gel found no antiplaque effect.
Among the animal studies, an L. sidoides mouthrinse significantly reduced calculus
in two studies, inflammatory infiltrate in one study, and plaque bacteria and
gingivitis in one study. An L. sidoides gel significantly reduced alveolar bone
loss and inflammatory response in one study in which mice were submitted to
ligature-induced periodontal disease. In general, L. sidoides -based products were
effective in reducing dental plaque and calculus formation, as well as clinical
signs of gingivitis. As most studies present methodological limitations, these
results should be interpreted carefully. Further clinical trials with greater
methodological accuracy and control of biases are necessary for the use of L.
sidoides -based products in humans to be viable in clinical practice.
AN - rayyan-563559871
AU - De Assis, E. L.
AU - Silveira, F. D.
AU - Da Ponte, A. V. A.
AU - Regis, R. R.
DO - 10.1055/a-1554-6947
IS - 5
KW - alcohol
biocide
biological product
carvacrol
caryophyllene
chlorhexidine
disinfectant agent
doxycycline
essential oil
flavonoid
interleukin 1beta
Lippia sidoides extract
mouthwash
myeloperoxidase
plant extract
terpene
thymol
toothpaste
unclassified drug
alveolar bone loss
bacterium adherence
biofilm
bleeding
burning sensation
clinical practice
crossover procedure (topic)
gingival index
gingivitis
halitosis
human
inflammation
inflammatory infiltrate
lipophilicity
Lippia sidoides
mouth hygiene
nonhuman
outcome assessment
periodontal disease
periodontitis
phytotherapy
plant
plaque index
review
Scopus
systematic review
tooth brushing
tooth calculus
tooth plaque
Verbenaceae
xerostomia
LA - English
PY - 2022
SN - ["1439-0221", "0032-0943"]
SP - 341-355
ST - A Systematic Review of the Potential Effects of Lippia sidoides on Dental
Plaque and Periodontal Diseases
T2 - Planta Med.
TI - A Systematic Review of the Potential Effects of Lippia sidoides on Dental
Plaque and Periodontal Diseases
VL - 88
ID - 13245
ER -
TY - JOUR
AB - Periodontitis is a chronic destructive infection of the tooth-supportive
tissues, which is caused by pathogenic bacteria such as Actinobacillus
actinomycetemcomitans. A severe form of periodontitis is found in Papillon-Lefèvre
syndrome (PLS), an inheritable disease caused by loss-of-function mutations in the
cathepsin C gene. Recently, we demonstrated that these patients lack the activity
of the polymorphonuclear leukocyte (PMN)-derived serine proteinases elastase,
cathepsin G, and proteinase 3. In the present study we identified possible pathways
along which serine proteinases may be involved in the defense against A.
actinomycetemcomitans. Serine proteinases are capable to convert the PMN-derived
hCAP-18 into LL-37, an antimicrobial peptide with activity against A.
actinomycetemcomitans. We found that the PMNs of PLS patients released lower levels
of LL-37. Furthermore, because of their deficiency in serine proteases, the PMNs of
PLS patients were incapable of neutralizing the leukotoxin produced by this
pathogen, which resulted in increased cell damage. Finally, the capacity of PMNs
from PLS patients to kill A. actinomycetemcomitans in an anaerobic environment,
such as that found in the periodontal pocket, seemed to be reduced. Our report
demonstrates a mechanism that suggests a direct link between an inheritable defect
in PMN functioning and difficulty in coping with a periodontitis- associated
pathogen. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
AN - rayyan-563560762
AU - De Haar, S. F.
AU - Hiemstra, P. S.
AU - Van Steenbergen, M. T. J. M.
AU - Everts, V.
AU - Beertsen, W.
DO - 10.1128/IAI.02016-05
IS - 9
KW - cathelicidin
ropocamptide
cathepsin G
dipeptidyl peptidase I
elastase
human cationic antimicrobial protein 18
leukotoxin
myeloblastin
serine proteinase
unclassified drug
article
cell damage
controlled study
degranulation
enzyme activity
gene mutation
host resistance
human
human cell
palmoplantar keratoderma
neutrophil
periodontitis
priority journal
Western blotting
LA - English
PY - 2006
SN - 0019-9567
SP - 5284-5291
ST - Role of polymorphonuclear leukocyte-derived serine proteinases in defense
against Actinobacillus actinomycetemcomitans
T2 - Infect. Immun.
TI - Role of polymorphonuclear leukocyte-derived serine proteinases in defense
against Actinobacillus actinomycetemcomitans
VL - 74
ID - 14136
ER -
TY - JOUR
AB - The healing process is a dynamic process accompanied by some classical
symptoms of inflammation such as redness, swelling, pain, and loss of function.
Chitosan is a natural polymer with properties that contribute to tissue healing,
with properties that could be applied in periodontal therapy, such as the wound
healing of oral mucosa. This experimental split-mouth study aims to assess the
possibilities of chitosan influencing the healing process of oral mucosa in eight
patients, where the studied group was subjected to two oral surgeries: one with
chitosan hydrogel into the socket and other without the biomaterial. A semi-
quantitative analysis of the data was performed. Some classic signs of inflammation
in a short period of time were observed where chitosan acted, compared to the
control. An absence of bleeding was observed in the chitosan cases. According to
the literature, chitosan recruits and activates neutrophils and macrophages and
stimulates angiogenesis. Hemostatic and antimicrobial activity of chitosan also
play an important role in wound healing. Chitosan seems to improve the
postoperative quality of patients, allowing rapid wound healing with less
complications.
AN - rayyan-563561357
AU - de Jesus, G.
AU - Marques, L.
AU - Vale, N.
AU - Mendes, R. A.
DO - 10.3390/nano13040706
IS - 4
J2 - Nanomaterials (Basel)
LA - eng
N1 - Centro Regional das Beiras, Universidade Católica Portuguesa, Estrada da
Circunvalação, 3504-505 Viseu, Portugal.; OncoPharma Research Group, Center for
Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa,
4200-450 Porto, Portugal.; CINTESIS@RISE, Faculty of Medicine, University of Porto,
Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.; OncoPharma Research
Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor
Plácido da Costa, 4200-450 Porto, Portugal.; CINTESIS@RISE, Faculty of Medicine,
University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.;
Department of Community Medicine, Information and Health Decision Sciences
(MEDCIDS), Faculty of Medicine, University of Porto, Rua Doutor Plácido da Costa,
4200-450 Porto, Portugal.; CINTESIS@RISE, Faculty of Medicine, University of Porto,
Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.; Department of
Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of
Medicine, University of Porto, Rua Doutor Plácido da Costa, 4200-450 Porto,
Portugal.; Department of Oral and Maxillofacial Medicine and Diagnostic Sciences,
Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106-7401, USA.
PY - 2023
SN - 2079-4991 (Print)
ST - The Effects of Chitosan on the Healing Process of Oral Mucosa: An
Observational Cohort Feasibility Split-Mouth Study
T2 - Nanomaterials (Basel, Switzerland)
TI - The Effects of Chitosan on the Healing Process of Oral Mucosa: An
Observational Cohort Feasibility Split-Mouth Study
VL - 13
Y2 - 2 y3 - 12
ID - 14731
ER -
TY - JOUR
AN - rayyan-563561802
AU - De Oliveira, J. S.
AU - Pinto, M. E. S. C.
AU - De Araujo De Bastos Santana, L.
AU - Pinto, A. S. B.
AU - Di Lenardo, D.
AU - Vasconcelos, D. F. P.
DO - 10.1155/2018/5656189
PY - 2018
ST - Corrigendum to: Biological effects of medicinal plants on induced
periodontitis: A systematic review (International Journal of Dentistry (2016) 2016
(3719879) DOI: 10.1155/2016/3719879)
T2 - International Journal of Dentistry
TI - Corrigendum to: Biological effects of medicinal plants on induced
periodontitis: A systematic review (International Journal of Dentistry (2016) 2016
(3719879) DOI: 10.1155/2016/3719879)
85048731926&doi=10.1155%2f2018%2f5656189&partnerID=40&md5=17a9220f423071932ef3922d3
7510dfc
VL - 2018
ID - 15176
ER -
TY - JOUR
AB - Introduction: Endotoxins are one of the etiologic agents involved in the
pathogenesis of apical periodontitis. The objectives of this clinical study were to
investigate the effects of endodontic treatment by using different irrigants on
endotoxins in root canals with pulp necrosis and apical periodontitis and to
evaluate the cytotoxic effects. Methods: Thirty-six root canals were selected.
Samples were collected before (S1) and after instrumentation (S2). The root canals
were divided into 3 groups (n = 12) according to the irrigant combination used: CLX
+ LW, 2% chlorhexidine gel + calcium hydroxide (0.14%, limewater); CLX + PmB,
chlorhexidine + polymyxin B; CLX (control), chlorhexidine + saline. The third
sampling (S3) was performed after ethylenediaminetetraacetic acid and S4 after
intracanal medication (CLX + calcium hydroxide for 14 days). Endotoxins were
quantified by the chromogenic Limulus amebocyte lysate assay, and cytotoxic effects
were evaluated by the production of cytokines (interleukin-1 beta, tumor necrosis
factor alpha) in macrophages (RAW 264.7) stimulated with the root canal content.
Results: Endotoxins were detected in all root canals before instrumentation (S1).
Group CLX + LW presented the greatest endotoxin reduction after instrumentation
(99.18%), which was similar to group CLX + PmB (96.42%, P > .05) and different from
group CLX (90.78%, P < .05). The intracanal medication promoted important endotoxin
neutralization, with a reduction of 99.2% to 100%. The root canal content induced a
higher production of tumor necrosis factor alpha and interleukin-1 beta in S1
samples compared with samples obtained after treatment. Conclusions: The
combination of CLX and limewater as irrigant was the most effective in reducing
endotoxins in root canals, and intracanal medication was important to neutralize
the cytotoxic effects. (J Endod 2012;38:1053-1057)
AN - rayyan-563562607
AU - de Oliveira, L. D.
AU - Carvalho, C. A. T.
AU - Alves, J. D.
AU - Valera, M. C.
AU - Jorge, A. O. C.
DO - 10.1016/j.joen.2012.04.015
IS - 8
PY - 2012
SN - ["0099-2399", "1878-3554"]
SP - 1053-1057
ST - Efficacy of Endodontic Treatment for Endotoxin Reduction in Primarily
Infected Root Canals and Evaluation of Cytotoxic Effects
TI - Efficacy of Endodontic Treatment for Endotoxin Reduction in Primarily
Infected Root Canals and Evaluation of Cytotoxic Effects
VL - 38
Y2 - 8
ID - 15981
ER -
TY - JOUR
AB - Introduction: Endotoxins are one of the etiologic agents involved in the
pathogenesis of apical periodontitis. The objectives of this clinical study were to
investigate the effects of endodontic treatment by using different irrigants on
endotoxins in root canals with pulp necrosis and apical periodontitis and to
evaluate the cytotoxic effects. Methods: Thirty-six root canals were selected.
Samples were collected before (S1) and after instrumentation (S2). The root canals
were divided into 3 groups (n = 12) according to the irrigant combination used: CLX
+ LW, 2% chlorhexidine gel + calcium hydroxide (0.14%, limewater); CLX + PmB,
chlorhexidine + polymyxin B; CLX (control), chlorhexidine + saline. The third
sampling (S3) was performed after ethylenediaminetetraacetic acid and S4 after
intracanal medication (CLX + calcium hydroxide for 14 days). Endotoxins were
quantified by the chromogenic Limulus amebocyte lysate assay, and cytotoxic effects
were evaluated by the production of cytokines (interleukin-1ß, tumor necrosis
factor α) in macrophages (RAW 264.7) stimulated with the root canal content.
Results: Endotoxins were detected in all root canals before instrumentation (S1).
Group CLX + LW presented the greatest endotoxin reduction after instrumentation
(99.18%), which was similar to group CLX + PmB (96.42%, P > .05) and different from
group CLX (90.78%, P < .05). The intracanal medication promoted important endotoxin
neutralization, with a reduction of 99.2% to 100%. The root canal content induced a
higher production of tumor necrosis factor α and interleukin-1β in S1 samples
compared with samples obtained after treatment. Conclusions: The combination of CLX
and limewater as irrigant was the most effective in reducing endotoxins in root
canals, and intracanal medication was important to neutralize the cytotoxic
effects. © 2012 American Association of Endodontists.
AN - rayyan-563560536
AU - De Oliveira, L. D.
AU - Carvalho, C. A. T.
AU - De Souza Alves, J.
AU - Valera, M. C.
AU - Jorge, A. O. C.
DO - 10.1016/j.joen.2012.04.015
IS - 8
calcium hydroxide
chlorhexidine
edetic acid
endotoxin
interleukin 1beta
polymyxin B
sodium chloride
adult
animal
article
cell line
comparative study
drug antagonism
drug effect
endodontics
human
Limulus lysate test
macrophage
methodology
middle aged
mouse
tooth pulp
tooth pulp disease
treatment outcome
LA - English
PY - 2012
SN - 0099-2399
SP - 1053-1057
ST - Efficacy of endodontic treatment for endotoxin reduction in primarily
infected root canals and evaluation of cytotoxic effects
T2 - J. Endod.
TI - Efficacy of endodontic treatment for endotoxin reduction in primarily
infected root canals and evaluation of cytotoxic effects
VL - 38
ID - 13910
ER -
TY - JOUR
AB - Objective: The aim of this study was to compare the use of two chlorhexidine-
based antimicrobial agents as an adjunct to mechanical therapy for the treatment of
peri-implant mucositis. Materials and methods: Thirty patients with peri-implant
mucositis were included in the study and randomized in two groups. In addition to
mechanical therapy, group A was treated with chlorhexidine 0.2% mouthwash, while
group B was treated with chlorhexidine 1% gel. Probing depth, plaque index and
bleeding index were recorded at each scheduled follow-up visit: ten days, 1 month
and 3 months after giving the patients the assigned formulation. Patients had to
fill in a questionnaire investigating their satisfaction and ease of use of the
product. Results: A total of 23 patients (13 in group A and 10 in group B) attended
all the follow-up visits. Chlorhexidine 0.2% mouthwash and chlorhexidine 1% gel
were equally useful in the treatment of peri-implant mucositis leading to the
reduction in inflammatory parameters. Probing depth decreased over time in both
groups. Patients showed preference for gel formulation even if they found it more
difficult to use. Conclusions: Adjunctive treatment with different chlorhexidine
formulations was beneficial to the treatment of peri-implant mucositis. Besides, no
differences could be found between 0.2% mouthwash and 1% gel. © 2012 John Wiley &
Sons A/S.
AN - rayyan-563560497
AU - De Siena, F.
AU - Francetti, L.
AU - Corbella, S.
AU - Taschieri, S.
AU - Del Fabbro, M.
DO - 10.1111/idh.12002
IS - 1
KW - chlorhexidine
mouthwash
aged
article
comparative study
controlled study
dental abutment
female
follow up
gel
gingiva bleeding
human
male
middle aged
periodontal pocket
periodontics
stomatitis
tooth implant
tooth plaque
LA - English
PY - 2013
SN - ["1601-5029", "1601-5037"]
SP - 41-47
ST - Topical application of 1% chlorhexidine gel versus 0.2% mouthwash in the
treatment of peri-implant mucositis. An observational study
T2 - Int. J. Dent. Hyg.
TI - Topical application of 1% chlorhexidine gel versus 0.2% mouthwash in the
VL - 11
ID - 13871
ER -
TY - COMP
AB - OBJECTIVE: The aim of this study was to compare the use of two chlorhexidine-
based antimicrobial agents as an adjunct to mechanical therapy for the treatment of
peri-implant mucositis. MATERIALS AND METHODS: Thirty patients with peri-implant
mucositis were included in the study and randomized in two groups. In addition to
mechanical therapy, group A was treated with chlorhexidine 0.2% mouthwash, while
group B was treated with chlorhexidine 1% gel. Probing depth, plaque index and
bleeding index were recorded at each scheduled follow-up visit: ten days, 1 month
and 3 months after giving the patients the assigned formulation. Patients had to
fill in a questionnaire investigating their satisfaction and ease of use of the
product. RESULTS: A total of 23 patients (13 in group A and 10 in group B) attended
all the follow-up visits. Chlorhexidine 0.2% mouthwash and chlorhexidine 1% gel
were equally useful in the treatment of peri-implant mucositis leading to the
reduction in inflammatory parameters. Probing depth decreased over time in both
groups. Patients showed preference for gel formulation even if they found it more
difficult to use. CONCLUSIONS: Adjunctive treatment with different chlorhexidine
formulations was beneficial to the treatment of peri-implant mucositis. Besides, no
differences could be found between 0.2% mouthwash and 1% gel.
AN - rayyan-563561387
AU - De Siena, F.
AU - Francetti, L.
AU - Corbella, S.
AU - Taschieri, S.
AU - Del Fabbro, M.
CY - England
DO - 10.1111/idh.12002
ET - 1
J2 - Int J Dent Hyg
KW - Aged
Anti-Infective Agents, Local/*administration & dosage
Chlorhexidine/*administration & dosage
Dental Implant-Abutment Design
Dental Implants/*adverse effects
Dental Plaque/drug therapy/therapy
Dental Plaque Index
Dental Scaling
Female
Follow-Up Studies
Gels
Gingival Hemorrhage/drug therapy/therapy
Humans
Male
Middle Aged
Mouthwashes/administration & dosage
Patient Satisfaction
Periodontal Index
Periodontal Pocket/drug therapy/therapy
Stomatitis/*drug therapy/therapy
LA - eng
N1 - Universitá degli Studi di Milano, Department of Biomedical, Surgical and
Dental Sciences, Research Centre in Oral Health, IRCCS Istituto Ortopedico
Galeazzi, Milan, Italy.
PY - 2013
SP - 41-7
ST - Topical application of 1% chlorhexidine gel versus 0.2% mouthwash in the
T2 - International journal of dental hygiene
TI - Topical application of 1% chlorhexidine gel versus 0.2% mouthwash in the
VL - 11
Y2 - 2
ID - 14761
ER -
TY - JOUR
AB - Acetylsalicylic acid (ASA) is commonly used as a non-steroidal anti-
inflammatory drug that interferes with multiple biological pathways. ASA acts by
stimulating osteogenesis and inhibiting osteoclastogenesis. Thus, the objective of
this study was to perform a systematic review and meta-analysis to evaluate the
effectiveness of the use of ASA in the bone regeneration in animal models. This
review was structured based on the PRISMA Statement and registered on PROSPERO
database according to protocol number #CDR42018111403. The quality of evidence was
assessed by using the Grades of Recommendation, Assessment, Development, and
Evaluation (GRADE). With the development of search strategies, we identified
studies on the use of ASA from the following databases: 1- Medline (via PubMed); 2
- Web of Science; 3 - Scopus; and 4 - EMBASE. A total of 296 articles were
identified and after screening the title, abstract, and full text, only 18 studies
were selected for qualitative analysis and 12 were selected for performance of the
quantitative analysis (meta-analysis). A meta-analysis of the amount of bone tissue
formed showed a significant advantage when ASA was locally used, revealing a mean
difference (MD) of 22.75% (95% CI: 15.39-30.12) p < 0.00001. Within the limitations
of the available data, the results were promising and showed that ASA can be
effective in bone formation in animal models.
AN - rayyan-563559935
AU - de Souza Rendohl, E.
AU - Miziara, L. N. B.
AU - Pimentel, A. C.
AU - Sendyk, W. R.
AU - Santiago Junior, J. F.
AU - Marão, H. F.
DO - 10.1016/j.bjoms.2020.08.051
IS - 10
acetylsalicylic acid
alginic acid
antithrombocytic agent
calcium phosphate
gamma interferon
hydrogel
interleukin 6
silk fibroin
adult
alternative hypothesis
alveolar bone
bone marrow mesenchymal stem cell
bone regeneration
bone tissue
calvaria
cell migration
cell proliferation
controlled study
drug efficacy
drug use
Embase
female
follow up
GRADE approach
human
human cell
local therapy
male
Medline
mesenchyme cell
meta analysis
nonhuman
null hypothesis
ossification
osteoblast
osteoclast
osteolysis
ovariectomy-induced osteoporosis
periodontal disease
review
Scopus
systematic review
systemic therapy
Web of Science
LA - English
PY - 2021
SN - ["1532-1940", "0266-4356"]
SP - E1-E16
ST - The influence of acetylsalicylic acid on bone regeneration: systematic review
and meta-analysis
T2 - Br. J. Oral Maxillofac. Surg.
TI - The influence of acetylsalicylic acid on bone regeneration: systematic review
and meta-analysis
VL - 59
ID - 13309
ER -
TY - JOUR
AB - Aim: The present work aimed at preparing mouth ulcer gel of Metronidazole
benzoate with the purpose of developing a dosage form for a very quick onset of
action. Objectives: The main objective of this study was to develop a local, oral
metronidazole benzoate (MET) delivery system that can be applied and removed by the
patient for the treatment of periodontal diseases. Material and Methods: All
ingredients were weighed accurately according to the required quantity. Carbapol
934 and propylene glycol were mixed in water. Metronidazole benzoate was dissolved
in suitable quantity of ethanol in another beaker. This dissolve drug was added to
above solution .Then the Peppermint oil, preservative and Triethanolamine were
added. Prepared gel characterized for appearance, pH, spredability, drug content
and in vitro drug release. Result and Discussion: The drug release was dependent on
the concentration of carbapol and concentration of propylene glycol. The Mouth
ulcer gel of Metronidazole benzoate showed acceptable mechanical characteristics
and satisfactory % drug release. The prepared gel was transparent with smooth
surface without any interactions between drug and polymer. B3 formulation showed
best results because all the parameter showed satisfactory results.
AN - rayyan-563560237
AU - Debaje, P. D.
AU - Bachhav, A. A.
AU - Gujrathi, N. A.
AU - Jadhav, A. G.
IS - 4
KW - alcohol
glycerol
methyl paraben
metronidazole
peppermint oil
preservative
propylene glycol
triethanolamine
water
article
drug formulation
drug release
gel
human
mouth ulcer
pH
viscosity
LA - English
PY - 2018
SN - 2230-7346
SP - 5992-5997
ST - Formulation and evaluation of metronidazole mouth ulcer gel
T2 - J. Global Trends Pharm. Sci.
TI - Formulation and evaluation of metronidazole mouth ulcer gel
VL - 9
ID - 13611
ER -
TY - JOUR
AB - This report describes the first results of an ongoing study of bacteremia
after endodontic treatment of teeth with Asymptomatic apical periodontitis. After
access cavity preparation, microbiological samples were taken from the root canal
under aseptic conditions in 4 single-rooted teeth in 4 patients. In treatment of 2
of the patients, the first 3 reamers (sizes 15-25) were deliberately used to a
level 2 mm beyond the apical foramen. In 2 patients the instrumentation ended
inside the root canal 1 mm short of the apical foramen. Blood samples were taken
from the patients during the endodontic instrumentation and 10 min after the
treatment was completed. Using lysis-filtration under anaerobic conditions, the
blood was passed through a cellulose membrane filter. The filters as well as the
root canal samples were incubated using an anaerobic technique. Anaerobic bacteria
were isolated from all root canals. In the 2 patients where overinstrumentation had
occurred, Propionibacterium acnes was recovered both from the root canals and from
the blood samples taken during and after the treatment had been completed.
Biochemical profiles, antibiotic susceptibility tests and electrophoresis of
soluble proteins revealed that Propionibacterium acnes isolated from the root canal
and blood samples were identical within patients, but varied between patients.
Facultative anaerobic bacteria including Streptococcus sanguis were recovered from
only one root canal sample and not from the blood samples.
AN - rayyan-563561144
AU - Debelian, G. J.
AU - Olsen, I.
AU - Tronstad, L.
IS - 6
bacterial protein
adult
article
bacteremia
bacterial infection
drug effect
endodontics
Gram negative anaerobic bacteria
human
microbiology
tooth pulp
LA - English
PY - 1992
SN - 0109-2502
SP - 248-254
ST - Profiling of Propionibacterium acnes recovered from root canal and blood
during and after endodontic treatment
T2 - Endod Dent Traumatol
TI - Profiling of Propionibacterium acnes recovered from root canal and blood
during and after endodontic treatment
VL - 8
ID - 14518
ER -
TY - JOUR
AB - We have previously demonstrated that anaerobic bacteria are the
microorganisms most frequently isolated from blood following endodontic therapy of
teeth with apical periodontitis. Phenotypic characterisation of the isolates
suggested that the bacteria in the blood originated from the root canal. The
present experiment using sodium dodecyl sulfate-polyacrylamide gel electrophoresis
(SDS-PAGE) was carried out in an effort to verify these findings, and to further
study the microorganisms involved in endodontic bacteremias. Soluble cellular
proteins were extracted from 11 reference strains and 26 bacterial isolates
recovered from the root canal and blood. These included Propionibacterium acnes,
Peptostreptococcus prevotii, Fusobacterium nucleatum, Prevotella intermedia.
Actinomyces israelii, Streptococcus intermedius, Streptococcus sanguis. The
electrophoretic patterns mostly confirmed the identity of the isolates as
determined by the biochemical and antimicrobial resistance tests. Furthermore, with
this typing method the species Prevotella intermedia and Prevotella nigrescens
could be differentiated. These species had been recovered from both root canal and
blood. Also, differences between subspecies of Fusobacterium nucleatum became
evident with SDS-PAGE, and the results indicated that the organism recovered from
the root canal and blood was Fusobacterium nucleatum subsp. vincentii. The
electrophoretic patterns of the different organisms isolated from the root canal
and the blood were similar, providing further evidence that the bacteria found in
the blood originated from the root canal.
AN - rayyan-563561055
AU - Olsen, I.
AU - Tronstad, L.
IS - 5
anaerobic bacterium
article
bacteremia
classification
endodontics
human
microbiology
tooth pulp
LA - English
PY - 1996
SN - 0909-8836
SP - 540-546
ST - Electrophoresis of whole-cell soluble proteins of microorganisms isolated
from bacteremias in endodontic therapy
T2 - Eur. J. Oral Sci.
TI - Electrophoresis of whole-cell soluble proteins of microorganisms isolated
from bacteremias in endodontic therapy
VL - 104
ID - 14429
ER -
TY - JOUR
AB - Oral focal infection, a concept neglected for several decades, is a subject
of controversy. Recent progress in classification and identification of oral
microorganisms has renewed interest in focal infection. The aim of this study was
to use phenotypic and genetic methods to trace microorganisms released into the
bloodstream during and after endodontic treatment back to their presumed source--
the root canal. Microbiological samples were taken from the root canals of 26
patients with asymptomatic apical periodontitis of single-rooted teeth. The blood
of the patients was drawn during and 10 minutes after endodontic therapy.
Microorganisms in blood were collected after anaerobic lysis filtration and
cultured anaerobically on blood agar plates. The phenotypic methods used for
characterization and tracing of microorganisms in blood and root canals were:
biochemical and antimicrobial susceptibility test, SDS-PAGE of whole-cell soluble
proteins, and gas chromatography of cellular fatty acids. Phenotypic data were
verified by DNA restriction patterns and corresponding ribotypes of the root canal
and blood isolates by using a computer-assisted system fro gel analysis. All root
canals contained anaerobic bacteria. The frequency of bacteremia varied from 31% to
54%. The microorganisms from the root canal and blood presented identical phenotype
and genetic characteristics within the patients examined. These characteristics
differed between patients. The present study demonstrated that endodontic treatment
can be the cause of anaerobic bacteremia and fungemia. The phenotypic and genetic
methods used appeared valuable for tracing microorganisms in the blood back to
their origin.
AN - rayyan-563561025
AU - Olsen, I.
AU - Tronstad, L.
DO - 10.1902/annals.1998.3.1.281
IS - 1
KW - bacterial DNA
bacterial protein
fatty acid
ribosome DNA
anaerobic bacterium
article
bacteremia
blood
chemistry
fungemia
genetics
human
microbiology
phenotype
Prevotella
tooth infection
tooth pulp
yeast
LA - English
PY - 1998
SN - 1553-0841
SP - 281-287
ST - Anaerobic bacteremia and fungemia in patients undergoing endodontic therapy:
an overview
T2 - Ann. Periodontol.
TI - Anaerobic bacteremia and fungemia in patients undergoing endodontic therapy:
an overview
VL - 3
ID - 14399
ER -
TY - JOUR
AN - rayyan-563561494
AU - Deepika, B. A.
AU - Ramamurthy, J.
AU - Girija, S.
DO - 10.5005/jp-journals-10015-2140
PY - 2022
SP - S23-S27
ST - Evaluation of the Antimicrobial Effect of Ocimum sanctum L. Oral Gel against
Anaerobic Oral Microbes: An In Vitro Study
T2 - World Journal of Dentistry
TI - Evaluation of the Antimicrobial Effect of Ocimum sanctum L. Oral Gel against
Anaerobic Oral Microbes: An In Vitro Study
85140465243&doi=10.5005%2fjp-journals-10015-
2140&partnerID=40&md5=74ac6586bc3d24a1be3d1958fa771ef2
VL - 13
ID - 14868
ER -
TY - JOUR
AB - Aloe vera is a plant that belongs to "Xanthorrhoeacea" family. It is used in
herbal medicine since 1st century AD. Clinical evaluations revealed that the
pharmacologically active ingredient is present in the gel and leaves. More than the
300 varieties of A. vera exists exhibiting its unique property. The use of herbal
products shows minimal side effect but highly effective treatment. Even though
there are various advances in fields of medicine, oral infections are considered as
a serious public health problem. A. vera is said to be as "Portable Nature's First
Aid Kit" and has also been used in dentistry for its beneficial properties in
various conditions. This review summarizes the various therapeutic application and
clinical uses of A. vera in dentistry. However, further research should be carried
out to unfold the various potential uses of A. vera plant in dentistry.
AN - rayyan-563560271
AU - Deepthi, K.
AU - Kumar, R. P.
IS - 1
aging
Aloe vera
antifungal activity
antiviral activity
aphthous stomatitis
bites and stings
burning sensation
dentistry
dermatitis
drug determination
human
lichen planus
nonhuman
osteitis
priority journal
review
skin redness
wound healing
LA - English
PY - 2018
SN - ["0974-6943", "0097-4694"]
SP - 1-3
ST - Aloe vera - Nature's healer
T2 - J. Pharm. Res.
TI - Aloe vera - Nature's healer
VL - 12
ID - 13645
ER -
TY - JOUR
AB - Historically, the field of regenerative medicine has aimed to heal damaged
tissue through the use of biomaterials scaffolds or delivery of foreign progenitor
cells. Despite 30 years of research, however, translation and commercialization of
these techniques has been limited. To enable mammalian regeneration, a more
practical approach may instead be to develop therapies that evoke endogenous
processes reminiscent of those seen in innate regenerators. Recently,
investigations into tadpole tail regrowth, zebrafish limb restoration, and the
super-healing Murphy Roths Large (MRL) mouse strain, have identified ancient
oxygen-sensing pathways as a possible target to achieve this goal. Specifically,
upregulation of the transcription factor, hypoxia-inducible factor one alpha (HIF-
1α) has been shown to modulate cell metabolism and plasticity, as well as
inflammation and tissue remodeling, possibly priming injuries for regeneration.
Since HIF-1α signaling is conserved across species, environmental or
pharmacological manipulation of oxygen-dependent pathways may elicit a regenerative
response in non-healing mammals. In this review, we will explore the emerging role
of HIF-1α in mammalian healing and regeneration, as well as attempts to modulate
protein stability through hyperbaric oxygen treatment, intermittent hypoxia
therapy, and pharmacological targeting. We believe that these therapies could
breathe new life into the field of regenerative medicine.
AN - rayyan-563560024
AU - DeFrates, K. G.
AU - Franco, D.
AU - Heber-Katz, E.
AU - Messersmith, P. B.
DO - 10.1016/j.biomaterials.2020.120646
1,4 dihydrophenonthrolin 4 one 3 carboxylic acid
4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide
antibiotic agent
bay 85 3924
cobalt chloride
daprodustat
deferoxamine
dimethyloxalylglycine
glass
glycine derivative
gsk 360a
hydrogel
hypoxia inducible factor prolyl hydroxylase inhibitor
iox 4
iron chelating agent
mesoporous bioactive glass
molidustat
oxygen
procollagen proline 2 oxoglutarate 4 dioxygenase
prolyl hydroxylase inhibitor
protocatechuic acid
recombinant erythropoietin
roxadustat
triazole derivative
unclassified drug
allergy
anemia
cell transplantation
chronic wound
drug dose increase
drug potentiation
drug protein binding
drug targeting
ear disease
enzyme active site
enzyme inhibition
eye disease
human
hyperbaric oxygen therapy
hypotension
infection
intermittent hypoxia
iron chelation
iron overload
kidney disease
lung disease
mammal
neurologic disease
nonhuman
oxygen therapy
periodontitis
priority journal
protein stability
review
signal transduction
skin manifestation
surgical debridement
tissue regeneration
wound
wound closure
wound healing
fg 4592
gsk 1278863
LA - English
PY - 2021
SN - ["1878-5905", "0142-9612"]
ST - Unlocking mammalian regeneration through hypoxia inducible factor one alpha
signaling
T2 - Biomaterials
TI - Unlocking mammalian regeneration through hypoxia inducible factor one alpha
signaling
VL - 269
ID - 13398
ER -
TY - JOUR
AB - Carbonic anhydrases (CAs, EC 4.2.1.1) belonging to the α-, β-, γ-, δ- and ζ-
CAs are ubiquitous metalloenzymes present in prokaryotes and eukaryotes. CAs
started to be investigated in detail only recently in pathogenic bacteria, in the
search for antibiotics with a novel mechanism of action, since it has been
demonstrated that in many such organisms they are essential for the life cycle of
the organism. CA inhibition leads to growth impairment or growth defects in several
pathogenic bacteria. The microbiota of the human oral mucosa consists of a myriad
of bacterial species, Porphyromonas gingivalis being one of them and the major
pathogen responsible for the development of chronic periodontitis. The genome of P.
gingivalis encodes for a β- and a γ-CAs. Recently, our group purified the
recombinant γ-CA (named PgiCA) which was shown to possess a significant catalytic
activity for the reaction that converts CO2 to bicarbonate and protons, with a kcat
of 4.1 × 105s-1 and a kcat/Km of 5.4 × 107M-1× s-1. We have also investigated its
inhibition profile with a range of inorganic anions such as thiocyanate, cyanide,
azide, hydrogen sulfide, sulfamate and trithiocarbonate. Here, we describe the
cloning, purification and kinetic parameters of the other class of CA identified in
the genome of P. gingivalis, the β-CA, named PgiCAb. This enzyme has a good
catalytic activity, with a kcat of 2.8 × 105s-1 and a kcat/Km of 1.5 × 107M-1× s-1.
PgiCAb was also inhibited by the clinically used sulfonamide acetazolamide, with an
inhibition constant of 214 nM. The role of CAs as possible virulence factors of P.
gingivalis is poorly understood at the moment but their good catalytic activity and
the fact that they might be inhibited by a large number of compounds, which may
pave the way for finding inhibitors with antibacterial activity that may elucidate
these phenomena and lead to novel antibiotics.
AN - rayyan-563560381
AU - Del Prete, S.
AU - Vullo, D.
AU - De Luca, V.
AU - Alothman, Z.
AU - Osman, S. M.
AU - Supuran, C. T.
AU - Capasso, C.
DO - 10.3109/14756366.2014.931383
IS - 3
KW - acetazolamide
azide
bacterial enzyme
bicarbonate
carbonate dehydratase
cyanide
hydrogen sulfide
proton
recombinant beta carbonic anhydrase
recombinant enzyme
sulfamate
sulfonamide
sulfur derivative
thiocyanate
unclassified drug
virulence factor
amino acid sequence
article
bacterial genome
catalysis
cloning
enzyme activity
enzyme inhibition
enzyme kinetics
enzyme purification
inhibition constant
isoenzyme analysis
kinetic parameters
nonhuman
nucleotide sequence
phylogeny
priority journal
sequence alignment
LA - English
PY - 2015
SN - ["1475-6374", "1475-6366"]
SP - 366-370
ST - Biochemical characterization of recombinant β-carbonic anhydrase (PgiCAb)
identified in the genome of the oral pathogenic bacterium Porphyromonas gingivalis
T2 - J. Enzyme Inhib. Med. Chem.
TI - Biochemical characterization of recombinant β-carbonic anhydrase (PgiCAb)
identified in the genome of the oral pathogenic bacterium Porphyromonas gingivalis
VL - 30
ID - 13755
ER -
TY - JOUR
AN - rayyan-563561600
AU - Demyanenko, S. A.
AU - Morozova, M. N.
AU - Pavlova, N. V.
AU - Marchenko, N. V.
AU - Shabliy, D. N.
AU - Kazinina, E. N.
AU - Tofan, Y. V.
AU - Kirichenko, V. N.
DO - 10.20969/VSKM.2022.15(3).15-20
IS - 3
PY - 2022
SP - 15-20
ST - MICROBIOTA OF THE ROOT CANAL SYSTEM IN PATIENTS WITH DESTRUCTIVE FORMS OF
CHRONIC APICAL PERIODONTITIS BEFORE AND AFTER STANDARD ENDODONTIC TREATMENT AND
MODERN POSSIBILITIES OF INFLUENCING IT
T2 - Vestnik Sovremennoi Klinicheskoi Mediciny
TI - MICROBIOTA OF THE ROOT CANAL SYSTEM IN PATIENTS WITH DESTRUCTIVE FORMS OF
CHRONIC APICAL PERIODONTITIS BEFORE AND AFTER STANDARD ENDODONTIC TREATMENT AND
MODERN POSSIBILITIES OF INFLUENCING IT
85135634418&doi=10.20969%2fVSKM.2022.15%283%29.15-
20&partnerID=40&md5=a58aba8d18227d96b6e53d46c24a0487
VL - 15
ID - 14974
ER -
TY - JOUR
AB - Doxycycline gel is licensed for the treatment of periodontal disease in dogs.
Package labeling indicates the product is stable after reconstitution of antibiotic
with polymer gel for up to 3-days when stored at room temperature. The purpose of
this study was to determine if reconstituted doxycycline gel retained antimicrobial
activity for greater than 3-days. The antibiotic activity of reconstituted
doxycycline gel was evaluated against antimicrobial testing strains of bacteria and
bacteria collected from throat swabs of 2 dogs using a standard disc diffusion
assay. Our results showed that reconstituted doxycycline gel retained undiminished
antimicrobial activity for a minimum of 8-weeks.
AN - rayyan-563560546
AU - Dennis, M.
AU - Wilson, T.
AU - Woodward, T.
IS - 2
doxycycline
animal
article
chemistry
dog
drug effect
Escherichia coli
gel
LA - English
PY - 2012
SN - 0898-7564
SP - 84-87
ST - Retention of antimicrobial activity after reconstitution of doxycycline gel
T2 - J Vet Dent
TI - Retention of antimicrobial activity after reconstitution of doxycycline gel
VL - 29
ID - 13920
ER -
TY - JOUR
AB - A 1-yr clinical trial was conducted in which, at the outset, 268 children
aged 9-11 yr were randomly assigned to the treatment or control group. At baseline
a clinical and radiographic assessment of dental caries was performed. Thereafter,
every morning in school, treated subjects self-applied, for 5 min, pre-trimmed
plastic trays containing a sponge rubber insert and filled with a 3% vancomycin
gel. Participants were monitored every 4-6 wk for their level of Streptococcus
mutans on specific surfaces. After 12 mth, the overall caries increment in treated
subjects averaged 1 less DF surface than in the controls (4.42 DFS vs. 3.43 DFS.
p=0.032). The reductions in caries were significant in fissures but not on the
smooth or approximal surfaces; also in newly erupting teeth but not in teeth
present at baseline.
AN - rayyan-563561204
AU - DePaola, P. F.
AU - Jordan, H. V.
AU - Soparkar, P. M.
IS - 3
KW - vancomycin
child
clinical study
clinical trial
controlled study
dental caries
drug therapy
follow up
gingivitis
human
microorganism
mouth hygiene
radiography
school child
therapy
tooth
LA - English
PY - 1977
SN - 0003-9969
SP - 187-191
ST - Inhibition of dental caries in school children by topically applied
vancomycin
T2 - ARCH. ORAL BIOL.
TI - Inhibition of dental caries in school children by topically applied
vancomycin
VL - 22
ID - 14578
ER -
TY - JOUR
AB - Aim: To evaluate and compare the clinical efficacy of subgingivally delivered
curcumin gel and hexigel as an adjunct to scaling and root planing in chronic
periodontitis patients. Materials and method:A total of 12 subjects of age 18-
55years were randomly selected for the study from the Out Patient Department. A
total of 36 sites with pocket depths ≥5 mm were chosen as a split mouth design at
three different sites in the same patient. After scaling and root planning, in
Group I -2% curcumin gel, in Group IIChlorhexidinegel(Hexigel) and in Group III-
placebo gel (control)was placed subgingivally. Clinical parameters such as gingival
index and plaque index were recorded at baseline, 7 days and 21 days. Pocket depth
was checked at baseline, 21 and 45 days. Results:All the groups showed
statistically significant reduction in gingival, plaque indices and pocket depth.
Group I(curcumin)as a local delivery agent showedcomparable results in terms of
pocket depth reduction as group II (Hexigel). Conclusion:Curcumin gel showed
effective results and thus, can be used as an alternate to chlorhexidine gel in
management of chronic periodontitis patient without any side effects.
AN - rayyan-563560103
AU - Desai, A.
AU - Kumar, H.
AU - Nishat, R.
AU - Aspalli, S.
AU - Nagappa, G.
AU - Anand Kumar, Y.
IS - 7
KW - carbopol 934
chlorhexidine
curcumin
placebo
adult
article
clinical article
comparative study
controlled study
dental scaling
drug efficacy
female
gingival index
human
male
outpatient
pH
plaque index
root planing
LA - English
PY - 2020
SN - 2515-8260
SP - 5299-5312
ST - Comparative evaluation of efficacy of subgingivally delivered 2% indigenously
prepared curcumin gel and 1% commercially available hexigel as an adjunct to
scaling and root planing in chronic periodontitis patients: A split mouth
randomized controlled clinical trial
TI - Comparative evaluation of efficacy of subgingivally delivered 2% indigenously
prepared curcumin gel and 1% commercially available hexigel as an adjunct to
scaling and root planing in chronic periodontitis patients: A split mouth
VL - 7
ID - 13477
ER -
TY - JOUR
AB - Chitosan, a biocompatible and biodegradable polysaccharide derived from
chitin, has surfaced as a material of promise for drug delivery and biomedical
applications. Different chitin and chitosan extraction techniques can produce
materials with unique properties, which can be further modified to enhance their
bioactivities. Chitosan-based drug delivery systems have been developed for various
routes of administration, including oral, ophthalmic, transdermal, nasal, and
vaginal, allowing for targeted and sustained release of drugs. Additionally,
chitosan has been used in numerous biomedical applications, such as bone
regeneration, cartilage tissue regeneration, cardiac tissue regeneration, corneal
regeneration, periodontal tissue regeneration, and wound healing. Moreover,
chitosan has also been utilized in gene delivery, bioimaging, vaccination, and
cosmeceutical applications. Modified chitosan derivatives have been developed to
improve their biocompatibility and enhance their properties, resulting in
innovative materials with promising potentials in various biomedical applications.
This article summarizes the recent findings on chitosan and its application in drug
delivery and biomedical science.
AN - rayyan-563559730
AU - Desai, N.
AU - Rana, D.
AU - Salave, S.
AU - Gupta, R.
AU - Patel, P.
AU - Karunakaran, B.
AU - Sharma, A.
AU - Giri, J.
AU - Benival, D.
AU - Kommineni, N.
IS - 4
KW - biopolymer
chitosan
chitosan derivative
cosmeceutical
cyclodextrin
dendrimer
hydrogel
microsphere
n carboxymethyl chitosan
n hydroxyalkyl chitosan
nanofiber
o hydroxyalkyl chitosan
polyurethane based chitosan
tyrosine glucan
unclassified drug
antifungal activity
antiviral activity
biocompatibility
biomedicine
bone regeneration
cardiac tissue regeneration
cartilage tissue regeneration
corneal regeneration
cross linking
deacetylation
decolorization
demineralization
deproteinization
enzyme assisted extraction
extraction
fermentation
fungal cell wall
human
intranasal drug administration
nonhuman
periodontal tissue regeneration
review
tissue regeneration
vaccination
wound healing
LA - English
PY - 2023
SN - 1999-4923
ST - Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications
T2 - Pharmaceutics
TI - Chitosan: A Potential Biopolymer in Drug Delivery and Biomedical Applications
VL - 15
ID - 13104
ER -
TY - JOUR
AB - The present work is carried out to study gel formulation in the treatment of
periodontal disease. Periodontal diseases are the group of disease occurring in the
sulcus-the gap between the gums and tooth. Carbopol can be utilized as an important
intra-pocket delivery vehicle for the treatment of the disease because it can
easily pass through a cannula into a periodontal pocket where it solidifies in situ
to deliver the therapeutic agent for a prolonged period. The use of Carbopol 934
gel base led to improvement in Metronidazole availability at the periodontal
pocket. Carbopol gel base containing Metronidazole studied for physicochemical
properties like drug release, syringybility, drug content and pH to evaluate the
characterization of the gel formulation. From the prepared formulations 0.5%
Carbopol gel base showed the highest release of Metronidazole (81.7%) than the 1%
Carbopol gel bases (27%) after 120 min. The thixotropic behavior of the gel was
expressed by its syringybility. It can be injected directly into the periodontal
pocket using a syringe or cannula. The results shown that syringybility and drug
release from the medicated gel decrease with the increase in the concentration of
Carbopol 934. © RJPT All right reserved.
AN - rayyan-563560586
AU - Desai, U. D.
AU - Baruwala, K. D.
AU - Mistry, S. H.
AU - Jadhav, A. G.
IS - 7
KW - carbopol 934
metronidazole
article
drug formulation
drug release
drug transport
gel
periodontal disease
periodontal pocket
pH
physical chemistry
syringybility
thixotropy
LA - English
PY - 2011
SN - ["0974-360X", "0974-3618"]
SP - 1073-1077
ST - Characterization of gel formulation for the treatment of periodontal disease
TI - Characterization of gel formulation for the treatment of periodontal disease
VL - 4
ID - 13960
ER -
TY - JOUR
AB - Objectives: The aim of this work was to review the current uses of
chlorhexidine (CHX) in dentistry based on its mechanism of action, whilst
highlighting the most effective protocols that render the highest clinical efficacy
whilst limiting adverse drug reactions. Methods: A literature search was conducted
using the key words chlorhexidine, mechanism of action, adverse effects, and
dentistry using databases in the University of Toronto library system. The titles
and abstracts were read, and relevant articles were selected. Results: A total of
1100 publications were identified, 100 were investigated, and 67 of them were used.
Out of the 67 selected articles, 12 were reviews on CHX; 5 articles focussed on CHX
gels; 13 focussed on CHX mouthwashes; 8 focussed on CHX products; 13 discussed
adverse effects associated with CHX; 13 focussed on periodontal pathology and
treatment; 6 focussed on implant periodontal and dental surgeries; 7 evaluated
effects on caries; 6 looked at the mechanisms of action; and 12 focussed on the
antibacterial and antimicrobial impact on the oral biome. There were multiple areas
of overlap amongst the articles, and results showed that CHX provides different
uses, but mainly as an adjunct to various treatments. Mouthwash was the most
superior medium when used in short time spans when mechanical prophylaxis was not
possible for the prevention of gingivitis and maintenance of oral hygiene. CHX
products are often used in periodontics, postoral surgical procedures, and as a
prophylaxis for multiple invasive procedures with minimal adverse effects. Tooth
staining was the most negative adverse effect reported by patients. Conclusions:
CHX's antimicrobial properties make it an ideal prophylactic when mechanical
debridement is not possible. CHX mouthwash appears to be more effective compared to
gels. Concentrations of 0.12% to 0.2% are recommended; any mouthwash with
concentrations above 0.2% will unnecessarily increase the unwanted side effects.
CHX is useful amongst various areas of dentistry including oral surgery,
periodontics, and even general dentistry. For long-term treatments, especially in
periodontitis patients (stage I-III) undergoing nonsurgical treatments, CHX chips
are recommended. CHX chips are also recommended as an adjunct to implant
debridement in patients with peri-implant mucositis and peri-implantitis over CHX
mouthwash and gels. (C) 2022 The Authors. Published by Elsevier Inc. on behalf of
FDI World Dental Federation.
AN - rayyan-563562506
AU - Deus, F. P.
AU - Ouanounou, A.
DO - 10.1016/j.identj.2022.01.005
IS - 3
PY - 2022
SN - ["0020-6539", "1875-595X"]
SP - 269-277
ST - Chlorhexidine in Dentistry: Pharmacology, Uses, and Adverse Effects
T2 - INTERNATIONAL DENTAL JOURNAL
TI - Chlorhexidine in Dentistry: Pharmacology, Uses, and Adverse Effects
VL - 72
Y2 - 6
ID - 15880
ER -
TY - JOUR
AB - The aim of this study was to formulate and evaluate the novel amoxicillin
trihydrate dental gel containing different hydrophilic polymers such as hydroxy
propyl methyl cellulose (HPMC), methyl cellulose (MC), sodium carboxy methyl
cellulose (Sod.CMC) and hydroxy propyl cellulose (HPC) in varied concentrations (5,
6, 6 and 9 %) for the treatment of periodontal diseases. Propylene glycol was used
as a co-solvent in the concentration 15-25%. The formulated dental gels were found
transparent, smooth and similar in color on physical observation. The pH of the
dental gels was found to be in the range of 6.03 to 6.34. The spreadability of the
gel was found to be in the range of 6.33 to 7.81 g-cm/sec. The viscosity values
ranged from 4322.89 cps to 4665.78 cps. Drug content was found to be in the range
of 95.93 to 99.31%. In-vitro drug release studies of formulations were carried out
in the Kishery-Chein diffusion cell which exhibited an extended release of drug
over a period of 7 hours. The pure drug and the best formulation were evaluated for
antimicrobial studies by serial dilution method using nutrient broth medium. It was
noticed that with increased drug concentration marked antimicrobial activity was
achieved. Thus the present formulation of amoxicillin trihydrate dental gel could
be suggested as a safe and beneficial dosage form for the treatment of periodontal
infections.
AN - rayyan-563560519
AU - Devi, S.
AU - Basavaraj, B. V.
AU - Bharath, S.
AU - Deveswaran, R.
AU - Madhavan, V.
IS - 1
KW - amoxicillin
methylcellulose
propylene glycol
article
Bacillus subtilis
bacterial strain
broth dilution
controlled study
drug determination
drug effect
drug formulation
drug release
Escherichia coli
gel
hydrophilicity
in vitro study
nanofabrication
nonhuman
pH measurement
physical chemistry
LA - English
PY - 2012
SN - 0975-5071
SP - 275-286
ST - Antimicrobial studies of extended release amoxicillin trihydrate dental gels
T2 - Der Pharm. Lett.
TI - Antimicrobial studies of extended release amoxicillin trihydrate dental gels
VL - 4
ID - 13893
ER -
TY - JOUR
AB - Background: The present study aims to evaluate and compare the effects of 1%
melatonin gel plus platelet-rich fibrin (PRF) and PRF alone in treatment of
furcation defects, clinically and radiographically using cone-beam computed
tomography. Methods: This split-mouth clinical trial included 23 patients with 46
bilateral Grade II furcation defects in first or second maxillary or mandibular
molars. Control group was treated with PRF alone while the test group was treated
with 1% melatonin gel and PRF. Clinical attachment level (CAL) and horizontal
probing depth (HPD) were primary outcome parameters while secondary outcome
parameters were pocket probing depth (PPD) and defect volume (DV) assessed at 3 and
6 months postoperatively. Results: Significantly greater mean reduction of PPD,
HPD, and CAL gain was observed in test group (2.23 ± 0.41, 2.36 ± 0.68, and 2.97 ±
0.62 mm, respectively) in comparison with control group (2.83 ± 0.78, 2.85 ± 0.67,
and 3.21 ± 0.86 mm, respectively) at 6 months. A significant reduction in the mean
DV was exhibited radiographically in test group (1.06 ± 0.5 mm3) as compared with
control group (3.94 ± 1.32 mm3) at the end of 6 months. Both the groups showed
improvements in assessed parameters. Conclusions: In Grade II furcation defects the
combination therapy of 1% melatonin + PRF shows a statistically significant degree
of bone fill within the periodontal tissues and also better results in terms of
decrease in PPD, HPD, and a greater CAL gain.
AN - rayyan-563559778
AU - Dhande, S. K.
AU - Rathod, S. R.
AU - Kolte, A. P.
AU - Lathiya, V. N.
AU - Kasliwal, P. A.
DO - 10.1002/JPER.23-0282
KW - adult
article
clinical article
clinical trial
cone beam computed tomography
controlled study
drug combination
drug therapy
female
human
human cell
male
mandible
maxilla
molar tooth
mouth
outcome assessment
periodontal disease
regeneration
melatonin
LA - English
PY - 2023
SN - 0022-3492
ST - Clinicoradiographic comparative evaluation of 1% melatonin gel plus platelet-
rich fibrin over platelet-rich fibrin alone in treatment of Grade II furcation
defects: A randomized controlled double-blind clinical trial
TI - Clinicoradiographic comparative evaluation of 1% melatonin gel plus platelet-
rich fibrin over platelet-rich fibrin alone in treatment of Grade II furcation
defects: A randomized controlled double-blind clinical trial
ID - 13152
ER -
TY - JOUR
AB - Oral diseases play a serious challenge to public health around the world.
When left untreated, both the mouth and also the remaining the body would be
adversely affected by oral diseases. Different treatment modalities are avail-able
for various dental diseases, but the most downside of those modern drug treatments
are the frequent side effects related to their use. This has contributed to
renewing interest in the development of novel plant-derived anti-infective natural
compounds. Curcumin is an anti-inflammatory agent that occurs naturally, with
different biological and medicinal properties. It has proven anti-inflammatory,
antioxidant, antimicrobial, hepato-protective, immuno-stimulant, antiseptic, and
anti-mutagenic properties. Due to these properties, it is especially useful in
dentistry for the treatment of periodontal diseases and oral cancers. Turmeric can
also be utilized in alternative treatments as a pit and fissure sealant, mouthwash
and subgingival irrigant. Its gel form can even be used as a local drug delivery
system. It is evaluated with a view to mitigate the human diseases, particularly in
cancer and its potential to reduce cancer risk. Curcumin has only negligible side
effects such as diar-rhoea, diarrhoea, allergic skin reaction, gastric pain. The
objective of this arti-cle is to review the efficacy and therapeutic properties of
curcumin in main-taining oral health.
AN - rayyan-563560093
AU - Dhivyadharshini, J.
AU - Ezhilarasan
AU - Somasundaram, J.
DO - 10.26452/ijrps.v11iSPL3.2913
KW - curcumin
article
cancer growth
cancer risk
cancer survival
cancer therapy
cell cycle arrest
corrosion
cytotoxicity
dental caries
Escherichia coli
gingiva fibromatosis
human
inflammation
leukoplakia
medicinal plant
melanoma
mouth cancer
mouth disease
oral mucositis
oxidative stress
periodontal disease
periodontitis
protein expression
signal transduction
tooth extraction
tooth plaque
tumor growth
wound healing
LA - English
PY - 2020
SN - 0975-7538
SP - 192-199
ST - Effectiveness of curcumin in oral diseases: An update
T2 - Int. J. Res. Pharm. Sci.
TI - Effectiveness of curcumin in oral diseases: An update
VL - 11
ID - 13467
ER -
TY - JOUR
AN - rayyan-563561664
AU - Dhivyadharshini, J.
DO - 10.26452/ijrps.v11iSPL3.2913
PY - 2020
SP - 192-199
ST - Effectiveness of curcumin in oral diseases: An update
T2 - International Journal of Research in Pharmaceutical Sciences
TI - Effectiveness of curcumin in oral diseases: An update
85090793457&doi=10.26452%2fijrps.v11iSPL3.2913&partnerID=40&md5=13c098883118637dd52
783054216a710
VL - 11
ID - 15038
ER -
TY - JOUR
AB - The present umbrella review aimed to characterize periodontal self-care
instructions, prescriptions, and motivational methods; evaluate the associated
periodontal outcomes; and provide integrated, evidence-based recommendations for
periodontal self-care in periodontally healthy orthodontic patients with fixed
appliances. The presently applied study protocol was developed in advance,
compliant with the PRISMA statement, and registered on PROSPERO (CRD42022367204).
Systematic reviews published in English without date restrictions were
electronically searched until 21 November 2022 across the PROSPERO Register and
Cochrane Library, Web of Science (Core Collection), Scopus, and MED-LINE/PubMed
databases. The study quality assessment was conducted through the AMSTAR 2 tool.
Seventeen systematic reviews were included. Powered and manual toothbrushes showed
no significant differences in biofilm accumulation, although some evidence revealed
significant improvements in inflammatory, bleeding, and periodontal pocket depth
values in the short term with powered toothbrushes. Chlorhexidine mouthwashes, but
no gels, varnishes, or pastes, controlled better biofilm accumulation and gingival
inflammation as adjuncts to toothbrushing, although only for a limited period.
Organic products, such as aloe vera and chamomile, proved their antimicrobial
properties, and herbal-based mouthwashes seemed comparable to CHX without its side
effects. Motivational methods also showed beneficial effects on periodontal biofilm
control and inflammation, while no evidence supported probiotics administration.
AN - rayyan-563562393
AU - Di Spirito, F.
AU - Amato, A.
AU - Di Palo, M. P.
AU - Cannata, D.
AU - Giordano, F.
AU - D'Ambrosio, F.
AU - Martina, S.
DO - 10.3390/dj11020035
IS - 2
PY - 2023
SN - 2304-6767
ST - Periodontal Management in Periodontally Healthy Orthodontic Patients with
Fixed Appliances: An Umbrella Review of Self-Care Instructions and Evidence-Based
Recommendations
T2 - DENTISTRY JOURNAL
TI - Periodontal Management in Periodontally Healthy Orthodontic Patients with
Recommendations
VL - 11
Y2 - 2
ID - 15767
ER -
TY - JOUR
AN - rayyan-563561493
AU - Di Spirito, F.
AU - Amato, A.
AU - Di Palo, M. P.
AU - Cannatà, D.
AU - Giordano, F.
AU - D’Ambrosio, F.
AU - Martina, S.
DO - 10.3390/dj11020035
IS - 2
PY - 2023
ST - Periodontal Management in Periodontally Healthy Orthodontic Patients with
Recommendations
T2 - Dentistry Journal
TI - Periodontal Management in Periodontally Healthy Orthodontic Patients with
Recommendations
85148737316&doi=10.3390%2fdj11020035&partnerID=40&md5=d50a29015526fcfa165698521b0e4
fcb
VL - 11
ID - 14867
ER -
TY - JOUR
AB - The tissue engineering strategy is a new approach for the regeneration of
cementum, which is essential for the regeneration of the periodontal tissue. This
strategy involves the cell cultures present in this tissue, called cementoblasts,
and located on an appropriate substrate for posterior implantation in the
regeneration site. Prior studies from our research group have shown that the
proliferation and viability of cementoblasts increase in the presence of the ionic
dissolution products of bioactive glass particles. Therefore, one possible approach
to obtaining adequate substrates for cementoblast cultures is the development of
composite membranes containing bioactive glass. In the present study, composite
films of chitosanpolyvinyl alcohol-bioactive glass containing different glass
contents were developed. Glutaraldehyde was also added to allow for the formation
of cross-links and changes in the degradation rate. The glass phase was introduced
in the material by a sol-gel route, leading to an organic-inorganic hybrid. The
films were characterized by Fourier-transformed infrared spectroscopy (FTIR),
scanning electron microscopy (SEM) with electron dispersive spectroscopy (EDS) and
X-ray diffraction (XRD) analysis. Bioactivity tests were also conducted by
immersion of the films in simulated body fluid (SBF). Films containing up to 30%
glass phase could be obtained. The formation of calcium phosphate was observed
after the immersion of the films. A calcium phosphate layer formed more quickly on
materials containing higher bioactive glass contents. In the hybrid containing 23%
bioactive glass, a complete layer was formed after 24 h immersion, showing the high
bioactivity of this material. However, despite the higher in vitro bioactivity, the
film with 23% glass showed lower mechanical properties compared with films
containing up to 17% glass.
AN - rayyan-563560613
AU - Dias, L. L. S.
AU - Mansur, H. S.
AU - Donnici, C. L.
AU - Pereira, M. M.
DO - 10.4161/biom.1.1.17449
IS - 1
glutaraldehyde
polyvinyl alcohol
article
biocompatibility
biodegradability
biological activity
biosynthesis
cell proliferation
cell viability
controlled study
gene expression
human
hydrolysis
in vitro study
ion exchange
periodontitis
spectroscopy
tensile strength
tissue engineering
X ray diffraction
LA - English
PY - 2011
SN - ["2159-2535", "2159-2527"]
SP - 114-119
ST - Synthesis and characterization of chitosan-polyvinyl alcohol-bioactive glass
hybrid membranes
T2 - BioMatter
TI - Synthesis and characterization of chitosan-polyvinyl alcohol-bioactive glass
hybrid membranes
VL - 1
ID - 13987
ER -
TY - JOUR
AB - The tissue engineering strategy is a new approach for the regeneration of
cementum, which is essential for the regeneration of the periodontal tissue. This
strategy involves the cell cultures present in this tissue, called cementoblasts,
and located on an appropriate substrate for posterior implantation in the
regeneration site. Prior studies from our research group have shown that the
proliferation and viability of cementoblasts increase in the presence of the ionic
dissolution products of bioactive glass particles. Therefore, one possible approach
to obtaining adequate substrates for cementoblast cultures is the development of
composite membranes containing bioactive glass. In the present study, composite
films of chitosan-polyvinyl alcohol-bioactive glass containing different glass
contents were developed. Glutaraldehyde was also added to allow for the formation
of cross-links and changes in the degradation rate. The glass phase was introduced
in the material by a sol-gel route, leading to an organic-inorganic hybrid. The
films were characterized by Fourier-transformed infrared spectroscopy (FTIR),
scanning electron microscopy (SEM) with electron dispersive spectroscopy (EDS) and
X-ray diffraction (XRD) analysis. Bioactivity tests were also conducted by
immersion of the films in simulated body fluid (SBF). Films containing up to 30%
glass phase could be obtained. The formation of calcium phosphate was observed
after the immersion of the films. A calcium phosphate layer formed more quickly on
materials containing higher bioactive glass contents. In the hybrid containing 23%
bioactive glass, a complete layer was formed after 24 h immersion, showing the high
bioactivity of this material. However, despite the higher in vitro bioactivity, the
film with 23% glass showed lower mechanical properties compared with films
containing up to 17% glass.
AN - rayyan-563560587
AU - Dias, L. L.
AU - Mansur, H. S.
AU - Donnici, C. L.
AU - Pereira, M. M.
DO - 10.4161/biom.1.1.17449
IS - 1
chitosan
glass
glutaraldehyde
polymer
polyvinyl alcohol
tissue scaffold
article
artificial membrane
cell proliferation
cell survival
tooth cementum
chemistry
Key words: bioactive glass
materials testing
mechanical stress
membrane
metabolism
methodology
periodontitis
periodontium
sol-gel
tissue engineering
X ray diffraction
LA - English
PY - 2011
SN - 2159-2535
SP - 114-119
ST - Synthesis and characterization of chitosan-polyvinyl alcohol-bioactive glass
hybrid membranes
T2 - Biomatter
TI - Synthesis and characterization of chitosan-polyvinyl alcohol-bioactive glass
hybrid membranes
VL - 1
ID - 13961
ER -
TY - JOUR
AB - RESUMEN El Aloe vera estimula la proliferación celular, poseeactividad
antibacteriana, antifúngica, antiinflamatoria y cicatrizante, entre otras
propiedades. Con el objetivo de describir el uso los productos derivados de esta
planta en el tratamiento de la enfermedad periodontal inflamatoria crónica, se
realizó una revisión de la bibliografía actualizada relacionada con el tema. Los
artículos se identificaron a través de la búsqueda automatizada en las bases de
datos Scielo, PubMed y EBSCO, de enero a abril del 2017. Fueron seleccionados 32
materiales, escritos en idioma español e inglés, publicados entre los años 2006 y
2017. Co esta revisión se constató que la actividad biológica de los compuestos
bioactivos del gel, son útiles para relacionar el efecto terapéutico del Aloe vera
en la enfermedad periodontal (AU).
ABSTRACT Aloe vera stimulates cellular proliferation and has antibacterial,
antifungal, anti-inflammatory and healing activity, among other properties. With
the aim of describing the usage of products prepared with this plant in the
treatment of the chronic inflammatory periodontal disease, a review of updated
bibliography related with the theme was carried out. The articles were found
through the automatic search in SciELO, PubMed and EBSCO databases, from January to
April 2017. There were chosen 32 items, written in Spanish and English, published
in the period 2006-2017. It was stated with the search that the biological activity
of the gel bioactive components are useful to relate the Aloe vera therapeutic
effect in the periodontal disease (AU).
AN - rayyan-563559880
AU - Díaz López, Odalys
AU - Toledo Pimentel, Bárbara
AU - Veloz Fariñas, Midiala
AU - Posada López, Ivia
AU - Navas Toledo, Anabell
IS - 3
KW - Aloe vera
Aplicaciones terapéuticas
Enfermedad periodontal
Periodontal disease
Therapeutic application
LA - es
PY - 2018
SN - 1684-1824
SP - 744-754
ST - El Aloe vera su aplicación terapéutica en la enfermedad periodontal
inflamatoria crónica
T2 - Rev. medica electron
TI - El Aloe vera su aplicación terapéutica en la enfermedad periodontal
inflamatoria crónica
UR - http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1684-
18242018000300016
VL - 40
Y2 - 6 y3 - 1
ID - 13254
ER -
TY - JOUR
AB - Objective: This review intended to evaluate the in vitro antibacterial effect
of natural plant extracts against periodontal pathogens responsible for periodontal
disease. Methods: The research was conducted in five English databases (PubMed,
Cochrane Library, Scopus, EBSCO, web of science) from January 2000 to June 2019.
Only articles in English and French were retrieved. The inclusion criteria
concerned all in vitro studies of the antibacterial activity of plant extracts on
periodontal bacteria. The Reports on in vivo trials, essential oils, pure compounds
have been excluded. The risk of bias was assessed using a standard approach.
Results: 51 studies were selected in this review. The outcomes of selected studies
expressed by the diameter of the zone of inhibition, the values of the minimum
inhibitory concentration and the minimum bactericidal concentration were included.
Out of the 51 studies, 25 have shown the antibacterial effect of plant extracts
against Aggregatibacter actinomycetemcomitans; 33 out of the 51 studies reported on
the effects against Porphyromanas gingivalis; 17 studies against Prevotella
intermedia names; 13 studies on Fusobacterium nucleatum; three studies on
Tannerella forsythia; and only one study against Treponema denticola. Conclusion:
Although there is a high heterogeneity in the results of the minimum inhibitory
concentration from one study to another, the results showed that plant extracts had
an antimicrobial activity on the major periodontal pathogens. Thus, they can serve
as alternatives to chemical antiseptic agents for the prevention and treatment of
periodontal diseases.
AN - rayyan-563562049
AU - Dib, K.
AU - Ennibi, O.
AU - Alaoui, K.
AU - Cherrah, Y.
AU - Filali-Maltouf, A.
DO - 10.1016/j.hermed.2021.100493
PY - 2021
SN - ["2210-8033", "2210-8041"]
ST - Antibacterial activity of plant extracts against periodontal pathogens: A
systematic review
T2 - JOURNAL OF HERBAL MEDICINE
TI - Antibacterial activity of plant extracts against periodontal pathogens: A
systematic review
VL - 29
Y2 - 10
ID - 15423
ER -
TY - JOUR
AB - The comprehensive treatment of periodontitis stage 2 to 4 aims at the
resolution of periodontal inflammation and “pocket closure”, which implies a
residual probing depth of ≤4 mm and a negative BoP. However, supportive periodontal
therapy (SPT) regularly leaves behind persistent periodontal pockets with 5 or more
mm in residual PPD and sites that often re-colonize and re-infect. Various
adjunctive options for subgingival instrumentation have been proposed to enhance
the antimicrobial effects to better control the re-infection of these residual
sites. The locally applied adjuncts, based on their anti-inflammatory effect, are
sodium hypochlorite antiseptic cleaning gel and cross-linked hyaluronic acid
(xHyA). Both recently moved into the focus of clinical research on non-surgical and
surgical therapy for periodontitis. The surgical use of xHyA indicates regenerative
potential, supporting periodontal regeneration. This case series retrospectively
analyzes the clinical benefits of the consecutive flapless application of sodium-
hypochlorite-based cleaning gel and xHyA at the SPT to achieve pocket closure,
thereby reducing the need for periodontal surgery. In 29 patients, 111 sites
received the treatment sequence. At 6-month re-evaluation, an overall PPD reduction
exceeding 2 mm was achieved, associated with a similar CAL gain (2.02 mm); the
bleeding tendency (BoP) was reduced by >60%. Pocket closure occurred in almost 25%
of all the sites. Within their limits, the present data suggest that the proposed
combined adjunctive treatment of residual active periodontal sites yielded
significant improvement in the clinical parameters. Further studies in RCT format
are required to confirm these observations.
AN - rayyan-563561249
AU - Diehl, D.
AU - Friedmann, A.
AU - Liedloff, P.
AU - Jung, R. M.
AU - Sculean, A.
AU - Bilhan, H.
DO - 10.3390/ma15196508
IS - 19
J2 - Materials (Basel)
LA - eng
N1 - Department of Periodontology, Faculty of Health, Witten/Herdecke University,
58455 Witten, Germany.; Institute of Pharmacology and Toxicology, Faculty of
Health, Witten/Herdecke University, 58455 Witten, Germany.; Department of
Periodontology, Faculty of Health, Witten/Herdecke University, 58455 Witten,
Germany.; Department of Periodontology, Faculty of Health, Witten/Herdecke
University, 58455 Witten, Germany.; Department of Periodontology, Faculty of
Health, Witten/Herdecke University, 58455 Witten, Germany.; Department of
Periodontology, School of Dental Medicine, University of Bern, 3012 Bern,
Switzerland.; Department of Periodontology, Faculty of Health, Witten/Herdecke
University, 58455 Witten, Germany.
PY - 2022
SN - 1996-1944 (Print)
ST - Adjunctive Application of Hyaluronic Acid in Combination with a Sodium
Hypochlorite Gel for Non-Surgical Treatment of Residual Pockets Reduces the Need
for Periodontal Surgery-Retrospective Analysis of a Clinical Case Series
T2 - Materials (Basel, Switzerland)
TI - Adjunctive Application of Hyaluronic Acid in Combination with a Sodium
for Periodontal Surgery-Retrospective Analysis of a Clinical Case Series
VL - 15
Y2 - 9 y3 - 20
ID - 14623
ER -
TY - JOUR
AN - rayyan-563561543
AU - Diehl, D.
AU - Friedmann, A.
AU - Liedloff, P.
AU - Jung, R. M.
AU - Sculean, A.
AU - Bilhan, H.
DO - 10.3390/ma15196508
IS - 19
PY - 2022
ST - Adjunctive Application of Hyaluronic Acid in Combination with a Sodium
for Periodontal Surgery—Retrospective Analysis of a Clinical Case Series
T2 - Materials
TI - Adjunctive Application of Hyaluronic Acid in Combination with a Sodium
for Periodontal Surgery—Retrospective Analysis of a Clinical Case Series
85139870683&doi=10.3390%2fma15196508&partnerID=40&md5=7370d6cd0e3a20ab5c24bdcb8f56d
eb0
VL - 15
ID - 14917
ER -
TY - JOUR
AB - Background: Oral commensals contribute to microbe-host symbiosis in
periodontal homeostasis, and Porphyromonas gingivalis (P. gingivalis) as the
keystone pathogen critically accounts for the shift of symbiosis to dysbiosis and
periodontal destruction. Nucleotide-binding oligomerization domain (NOD)-like
receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome-mediated
interleukin-1β (IL-1β) is significantly involved in periodontal diseases, and
notably P. gingivalis enables to modulate the induction and expression of NLRP3.
Whereas, the exact mechanism by which NLRP3 inflammasome is regulated in response
to commensal and pathogenic bacteria remains unclear. Methods: To examine the
expression of IL-1β and NLRPs inflammasome in tissues with severe chronic
periodontitis, and further investigate how Caspase-4-dependent non-canonical NLRP3
inflammasome pathways functioned during the interactions of Streptococcus mitis (S.
mitis) and P. gingivalis with human THP-1 cells. Results: IL-1β and NLRP3, NLRP6,
NLRP12, and absent in melanoma 2 (AIM2) inflammasomes are highly expressed in
gingival tissues with severe chronic periodontitis. In human THP-1 cells, P.
gingivalis activates the synthesis and secretion of IL-1β to higher levels than S.
mitis. Importantly, NLRP3-, Caspase-1-, and Caspase-4-siRNA knockdown THP-1 cells
treated with P. gingivalis exhibited a lower expression level of IL-1β as compared
to the control cells. In addition, silencing of either CASP4 or CASP1 can lead to a
concurrent or reciprocal decrease in the expression of the other. Of note, the IL-
1β induction is not affected in the S. mitis-treated THP-1 cells with the silence
of NLRP3, Caspase-1, and Caspase-4 genes. Conclusion: NLRP3/Caspase-4 and
NLRP3/Caspase-1 dependent IL-1β production may crucially contribute to the
dysregulated immuno-inflammatory response in periodontal pathogenesis.
AN - rayyan-563560107
AU - Ding, P. H.
AU - Yang, M. X.
AU - Wang, N. N.
AU - Jin, L. J.
AU - Dong, Y.
AU - Cai, X.
AU - Chen, L. L.
DO - 10.3389/fmicb.2020.01881
KW - polymerase chain reaction system
ELISA kit
microplate reader
ND-1000
PCR assay kit
spectrophotometer
antibody
caspase 4
cryopyrin
cytokine
formaldehyde
inflammasome
interleukin 1beta
nucleotide binding oligomerization domain like receptor
probiotic agent
supersignal
trizol
xylene
article
cell culture
cell viability
controlled study
gingival tissue
human
human cell
human tissue
immunoblotting
melanoma
nonhuman
paraffin embedding
RNA interference
Streptococcus mitis
THP-1 cell line
Western blotting
ABI 7500
LA - English
PY - 2020
SN - 1664-302X
ST - Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its
Downstream Interleukin-1β Release Depend on Caspase-4
TI - Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its
Downstream Interleukin-1β Release Depend on Caspase-4
VL - 11
ID - 13481
ER -
TY - JOUR
AB - Using bioactive nanomaterials in clinical treatment has been widely aroused.
Nanomaterials provide substantial improvements in the prevention and treatment of
oral and maxillofacial diseases. This review aims to discuss new progresses in
nanomaterials applied to oral and maxillofacial tissue regeneration and disease
treatment, focusing on the use of nanomaterials in improving the quality of oral
and maxillofacial healthcare, and discuss the perspectives of research in this
arena. Details are provided on the tissue regeneration, wound healing,
angiogenesis, remineralization, antitumor, and antibacterial regulation properties
of nanomaterials including polymers, micelles, dendrimers, liposomes, nanocapsules,
nanoparticles and nanostructured scaffolds, etc. Clinical applications of
nanomaterials as nanocomposites, dental implants, mouthwashes, biomimetic dental
materials, and factors that may interact with nanomaterials behaviors and
bioactivities in oral cavity are addressed as well. In the last section, the
clinical safety concerns of their usage as dental materials are updated, and the
key knowledge gaps for future research with some recommendation are discussed. This
article is categorized under: Implantable Materials and Surgical Technologies >
Nanomaterials and Implants Implantable Materials and Surgical Technologies >
Nanotechnology in Tissue Repair and Replacement.
AN - rayyan-563560013
AU - Ding, Q.
AU - Cui, J.
AU - Shen, H.
AU - He, C.
AU - Wang, X.
AU - Shen, S. G. F.
AU - Lin, K.
DO - 10.1002/wnan.1669
IS - 2
KW - tooth implant
dendrimer
dental material
hydrogel
iron nanoparticle
liposome
mouthwash
nanocapsule
nanoliposome
nanomaterial
nanoparticle
polymer
unclassified drug
adverse event
alveolar bone
angiogenesis
bone mineralization
bone regeneration
bone structure
cancer therapy
cartilage
cytotoxicity
dental procedure
dental restoration
dentin
drug impurity
drug stability
ear cartilage
enamel
facial nerve
health care
health care quality
human
innervation
maxilla
mouth cancer
mouth cavity
mouth disease
mouth tissue
nanopharmaceutics
nanotechnology
nanotoxicology
nerve regeneration
nonhuman
nose cartilage
orthodontics
particle size
periodontitis
periodontium
polymerization
priority journal
prosthodontics
reverse micelle
review
salivary gland
soft tissue
surface property
temporomandibular joint
tissue regeneration
tissue repair
tooth
tooth cementum
tooth germ
tooth pulp
treatment indication
trigeminal nerve
wound healing
LA - English
PY - 2021
SN - ["1939-0041", "1939-5116"]
ST - Advances of nanomaterial applications in oral and maxillofacial tissue
regeneration and disease treatment
T2 - Wiley Interdiscip. Rev. Nanomedicine Nanobiotechnology
TI - Advances of nanomaterial applications in oral and maxillofacial tissue
regeneration and disease treatment
VL - 13
ID - 13387
ER -
TY - JOUR
AB - Innovative methodologies combined with scavenging reactive oxygen species
(ROS), alleviating oxidative stress damage and promoting macrophage polarization to
M2 phenotype may be ideal for remodeling implant-infected bone tissue. Herein, a
functionalization strategy for doping Tannic acid-d-tyrosine nanoparticles with
photothermal profile into the hydrogel coating composed of konjac gum and gelatin
on the surface of titanium (Ti) substrate is accurately constructed. The prepared
hydrogel coating exhibits excellent properties of eliminating biofilm and killing
planktonic bacteria, which is based on increasing susceptibility to bacteria by the
photothermal effect, biofilm-dissipation effect of D-tyrosine, as well as the
bactericidal effect of tannic acid. In addition, the modified Ti substrate has
effectively alleviated proinflammatory responses by scavenging intracellular
excessive ROS and guiding macrophages polarization toward M2. More interesting,
conditioned medium from macrophage indicates that paracrine is conducive to
osteogenic proliferation and differentiation of mesenchymal stem cells. Results
from rat model of femur infection in vivo demonstrate that the modified Ti implant
significantly eliminates the residual bacteria, relieves inflammation, mediates
macrophage polarization, and accelerates osseointegration. Altogether, this study
exhibits a new perspective for the development of advanced functional implant with
great application potential in bone tissue regeneration and repair.
AN - rayyan-563562494
AU - Ding, Y.
AU - Liu, G. H.
AU - Liu, S. P.
AU - Li, X.
AU - Xu, K.
AU - Liu, P.
AU - Cai, K. Y.
DO - 10.1002/adhm.202300722
PY - 2023
SN - ["2192-2640", "2192-2659"]
ST - A Multifunction Hydrogel-Coating Engineered Implant for Rescuing Biofilm
Infection and Boosting Osseointegration by Macrophage-Related Immunomodulation
T2 - ADVANCED HEALTHCARE MATERIALS
TI - A Multifunction Hydrogel-Coating Engineered Implant for Rescuing Biofilm
Infection and Boosting Osseointegration by Macrophage-Related Immunomodulation
Y2 - 5 y3 - 18
ID - 15868
ER -
TY - JOUR
AB - A satisfactory clinical effect in treating periodontitis is often difficult
to achieve by conventional non-surgical systemic drug delivery due to the narrow
anatomical structure of the periodontal pocket and insufficient drug concentration
at lesion sites. In addition, the feasibility of combating periodontal tissue
lesions by restoring the alveolar bone and allowing collagen regeneration has not
been fully explored. The objective of this study was to prepare a microemulsion
integrating the anti-inflammatory and osteogenic active ingredients of baicalin and
clove oil (BC-MEs). Then, the composite hydrogel obtained by mixing poloxamer 407
and 188 was used as the thermosensitive gel matrix to load BC-MEs and form a drug
reservoir (Gel-BC-MEs) injectable in situ. Gel-BC-MEs exhibited a significant,
sustained release of baicalin for 12 h, gelation temperature was 33.4 ± 0.36 °C,
and pH was 5.45 ± 0.12. The experiment on a rat periodontitis model demonstrated
that Gel-BC-MEs significantly improved periodontal tissue repair by collagen
regeneration and osteogenesis by inhibiting osteoclast infiltration. This study
proposes a novel strategy for periodontal tissue repair by enhancing the
therapeutic potential of a microemulsion using an in situ nano-gel delivery system.
AN - rayyan-563559759
AU - Ding, Y.
AU - Wang, Y.
AU - Li, J.
AU - Tang, M.
AU - Chen, H.
AU - Wang, G.
AU - Guo, J.
AU - Gui, S.
DO - 10.1080/10837450.2022.2161574
IS - 1
KW - particle size analyzer
baicalin
collagen
hydrogel
minocycline
poloxamer
alveolar bone
alveolar crest
anatomical concepts
animal cell
animal experiment
animal model
article
bone development
bone erosion
bone tissue
controlled study
drug concentration
gelation
general anesthesia
gingiva
histology
in vitro study
male
Masson staining
maxilla
maxillary second molar
microemulsion
molar tooth
nonhuman
particle size
periodontal pocket
periodontitis
pH
pH measurement
rat
regeneration
system analysis
therapy
therapy effect
tissue injury
tissue repair
zeta potential
LA - English
PY - 2023
SN - ["1097-9867", "1083-7450"]
SP - 30-39
ST - Microemulsion-thermosensitive gel composites as in situ-forming drug
reservoir for periodontitis tissue repair through alveolar bone and collagen
regeneration strategy
TI - Microemulsion-thermosensitive gel composites as in situ-forming drug
reservoir for periodontitis tissue repair through alveolar bone and collagen
regeneration strategy
VL - 28
ID - 13133
ER -
TY - JOUR
AB - PurposePeri-implantitis is one of the most common inflammatory complications
in dental implantology. Similar to periodontitis, in peri-implantitis, destructive
inflammatory changes take place in the tissues surrounding a dental implant.
Bacterial flora at the failing implant sites resemble the pathogens in periodontal
disease and consist of Gram-negative anaerobic bacteria including Aggregatibacter
actinomycetemcomitans (Aa). Here we demonstrate the effectiveness of a silver
lactate (SL)-containing RGD-coupled alginate hydrogel scaffold as a promising stem
cell delivery vehicle with antimicrobial properties. Materials and MethodsGingival
mesenchymal stem cells (GMSCs) or human bone marrow mesenchymal stem cells
(hBMMSCs) were encapsulated in SL-loaded alginate hydrogel microspheres. Stem cell
viability, proliferation, and osteo-differentiation capacity were analyzed.
ResultsOur results showed that SL exhibited antimicrobial properties against Aa in
a dose-dependent manner, with 0.50 mg/ml showing the greatest antimicrobial
properties while still maintaining cell viability. At this concentration, SL-
containing alginate hydrogel was able to inhibit Aa growth on the surface of Ti
discs and significantly reduce the bacterial load in Aa suspensions. Silver ions
were effectively released from the SL-loaded alginate microspheres for up to 2
weeks. Osteogenic differentiation of GMSCs and hBMMSCs encapsulated in the SL-
loaded alginate microspheres were confirmed by the intense mineral matrix
deposition and high expression of osteogenesis-related genes. ConclusionTaken
together, our findings confirm that GMSCs encapsulated in RGD-modified alginate
hydrogel containing SL show promise for bone tissue engineering with antimicrobial
properties against Aa bacteria in vitro.
AN - rayyan-563562171
AU - Diniz, I. M. A.
AU - Chen, C.
AU - Ansari, S.
AU - Zadeh, H. H.
AU - Moshaverinia, M.
AU - Chee, D.
AU - Marques, M. M.
AU - Shi, S. T.
AU - Moshaverinia, A.
DO - 10.1111/jopr.12316
IS - 2
PY - 2016
SN - ["1059-941X", "1532-849X"]
SP - 105-115
ST - Gingival Mesenchymal Stem Cell (GMSC) Delivery System Based on RGD-Coupled
Alginate Hydrogel with Antimicrobial Properties: A Novel Treatment Modality for
Peri-Implantitis
T2 - JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY
TI - Gingival Mesenchymal Stem Cell (GMSC) Delivery System Based on RGD-Coupled
Peri-Implantitis
VL - 25
Y2 - 2
ID - 15545
ER -
TY - JOUR
AN - rayyan-563561808
AU - Diniz, I. M. A.
AU - Chen, C.
AU - Ansari, S.
AU - Zadeh, H. H.
AU - Chee, D.
AU - Marques, M. M.
AU - Shi, S.
DO - 10.1111/jopr.12316
IS - 2
PY - 2016
SP - 105-115
Peri-Implantitis
T2 - Journal of Prosthodontics
Peri-Implantitis
84958874055&doi=10.1111%2fjopr.12316&partnerID=40&md5=29828ca4c1cdb8bcf55183b8b4897
85d
VL - 25
ID - 15182
ER -
TY - JOUR
AB - PURPOSE: Peri-implantitis is one of the most common inflammatory
complications in dental implantology. Similar to periodontitis, in peri-
implantitis, destructive inflammatory changes take place in the tissues surrounding
a dental implant. Bacterial flora at the failing implant sites resemble the
pathogens in periodontal disease and consist of Gram-negative anaerobic bacteria
including Aggregatibacter actinomycetemcomitans (Aa). Here we demonstrate the
effectiveness of a silver lactate (SL)-containing RGD-coupled alginate hydrogel
scaffold as a promising stem cell delivery vehicle with antimicrobial properties.
MATERIALS AND METHODS: Gingival mesenchymal stem cells (GMSCs) or human bone marrow
mesenchymal stem cells (hBMMSCs) were encapsulated in SL-loaded alginate hydrogel
microspheres. Stem cell viability, proliferation, and osteo-differentiation
capacity were analyzed. RESULTS: Our results showed that SL exhibited antimicrobial
properties against Aa in a dose-dependent manner, with 0.50 mg/ml showing the
greatest antimicrobial properties while still maintaining cell viability. At this
concentration, SL-containing alginate hydrogel was able to inhibit Aa growth on the
surface of Ti discs and significantly reduce the bacterial load in Aa suspensions.
Silver ions were effectively released from the SL-loaded alginate microspheres for
up to 2 weeks. Osteogenic differentiation of GMSCs and hBMMSCs encapsulated in the
SL-loaded alginate microspheres were confirmed by the intense mineral matrix
deposition and high expression of osteogenesis-related genes. CONCLUSION: Taken
together, our findings confirm that GMSCs encapsulated in RGD-modified alginate
hydrogel containing SL show promise for bone tissue engineering with antimicrobial
properties against Aa bacteria in vitro.
AN - rayyan-563560356
AU - Diniz, I. M.
AU - Chen, C.
AU - Ansari, S.
AU - Zadeh, H. H.
AU - Chee, D.
AU - Marques, M. M.
AU - Shi, S.
DO - 10.1111/jopr.12316
IS - 2
KW - alginic acid
antiinfective agent
polyethylene glycol dimethacrylate hydrogel
bone development
human
mesenchymal stroma cell
periimplantitis
LA - English
PY - 2016
SN - 1532-849X
SP - 105-115
Peri-Implantitis
T2 - J Prosthodont
Peri-Implantitis
VL - 25
ID - 13730
ER -
TY - JOUR
AB - Context: This research was conducted to appear the effectiveness of milkfish
scales chitosan gel (Chanos Chanos) on the inhibition of Aggregatibacter
actinomycetemcomitans which is a pathogenic bacterium that causes periodontitis.
This research was conducted with five treatments with five repetitions, five
treatments, namely: Positive control (metronidazole), negative control (aquadest),
chitosan gel in milkfish scales concentration of 1%, 5%, and 10%. This research
measuring instrument uses a calipers in units of millimeters (mm). Based on the
results of the Mann Whitney test, there was a significant difference in inhibition
of chitosan gel in 1%, 5%, and 10% milkfish gel against Aggregatibacter
actinomycetemcomitans bacteria (p <0.005), and based on the Kruskal Wallis test it
was found that the higher concentration of milkfish scale then the higher the
average inhibition power. It was concluded that milkfish scales gel chitosan
(Chanos chanos) can inhibit the growth of Aggregatibacter actinomycetemcomitans and
the higher the concentration of chitosan gel in milkfish scales, the higher the
inhibitory zone produced.
AN - rayyan-563560131
AU - Djais, A.
AU - Achmad, H.
AU - Jannah, M.
IS - 3
KW - chitosan
metronidazole
oxacillin
adult
agar diffusion
article
bacterium isolate
colony forming unit
comparative study
controlled study
human
middle aged
nonhuman
periodontitis
rank sum test
zone of inhibition
LA - English
PY - 2020
SN - ["0976-5506", "0976-0245"]
SP - 1863-1867
ST - Antibacterial chitosan of Milkfish scales (Chanos Chanos) onbacteria
TI - Antibacterial chitosan of Milkfish scales (Chanos Chanos) onbacteria
VL - 11
ID - 13505
ER -
TY - JOUR
AB - Mineral trioxide aggregate (MTA) is a powder aggregate containing mineral
oxides with a good biological action and may facilitate the regeneration of the
periodontal ligament and formation of bone. Calcium hydroxide demonstrates
antibacterial properties, enhances tissue dissolution, and induces bone formation.
The objective of this study was to evaluate the MTA in the bone healing process and
verify if the calcium hydroxide P.A. can improve and accelerate this process. It
was used forty male Wistar rats, which were divided into two groups, considering or
not the use of calcium hydroxide P.A. solution before treatment. Thus, each one of
these groups was divided in four groups with five animals each, according to the
treatment and the defect filled by: animal's coagulum, monoolein gel, MTA in
aqueous solution, and MTA combined with monoolein gel. After 10 days, the animals
were perfused and the right hemimandibles removed for histological analysis.
Statistical analysis of the data showed significant difference between all analyzed
groups when it was made comparisons using or not calcium hydroxide P.A. (p <
0.0001). There was found statistical difference between the groups that was
inserted or not MTA, independently the calcium hydroxide application (p < 0.05).
Results showed that the MTA used was able to induce bone regeneration and had its
action optimized when combined to calcium hydroxide P.A. © 2007 Elsevier Ltd. All
rights reserved.
AN - rayyan-563560697
AU - do Nascimento, C.
AU - Issa, J. P. M.
AU - Iyomasa, M. M.
AU - Regalo, S. C. H.
AU - Siéssere, S.
AU - Pitol, D. L.
AU - Wolga, N. d O.
AU - Pedrazzi, V.
DO - 10.1016/j.micron.2007.12.004
IS - 7
KW - aluminum derivative
calcium derivative
calcium hydroxide
drug carrier
mineral trioxide aggregate
oxide
silicate
animal
article
bone
bone development
cytology
drug combination
drug effect
injury
male
mandible
metabolism
physiology
rat
Wistar rat
LA - English
PY - 2008
SN - 0968-4328
SP - 868-874
ST - Bone repair using mineral trioxide aggregate combined to a material carrier,
associated or not with calcium hydroxide in bone defects
T2 - Micron
TI - Bone repair using mineral trioxide aggregate combined to a material carrier,
VL - 39
ID - 14071
ER -
TY - JOUR
was used forty rnale Wistar rats, which were divided into two groups, considering
or not the use of calcium hydroxide P.A. solution before treatment. Thus, each one
of these groups was divided in four groups with five animals each, according to the
groups when it was made comparisons using or not calcium hydroxide P.A. (p <
0.0001). There was found statistical difference between the groups that was
inserted or not MTA, independently the calcium hydroxide application (p < 0.05).
Results showed that the MTA used was able to induce bone regeneration and had its
action optimized when combined to calcium hydroxide P.A. (C) 2007 Elsevier Ltd. All
rights reserved.
AN - rayyan-563562588
AU - Issa, J. P. M.
AU - Iyomasa, M. M.
AU - Regalo, S. C. H.
AU - Siessere, S.
AU - Pitol, D. L.
AU - Wolga, N. D.
AU - Pedrazzi, V.
DO - 10.1016/j.micron.2007.12.004
IS - 7
PY - 2008
SN - 0968-4328
SP - 868-874
T2 - MICRON
VL - 39
Y2 - 10
ID - 15962
ER -
TY - JOUR
was used forty male Wistar rats, which were divided into two groups, considering or
not the use of calcium hydroxide P.A. solution before treatment. Thus, each one of
these groups was divided in four groups with five animals each, according to the
groups when it was made comparisons using or not calcium hydroxide P.A. (p<0.0001).
There was found statistical difference between the groups that was inserted or not
MTA, independently the calcium hydroxide application (p<0.05). Results showed that
the MTA used was able to induce bone regeneration and had its action optimized when
combined to calcium hydroxide P.A.
AN - rayyan-563561422
AU - Issa, J. P.
AU - Iyomasa, M. M.
AU - Regalo, S. C.
AU - Siéssere, S.
AU - Pitol, D. L.
AU - de Oliveira Wolga, N.
AU - Pedrazzi, V.
DO - 10.1016/j.micron.2007.12.004
IS - 7
J2 - Micron
KW - Aluminum Compounds/*metabolism
Animals
Bone and Bones/*drug effects/injuries/*physiology
Calcium Compounds/*metabolism
Calcium Hydroxide/*pharmacology
Drug Carriers/*therapeutic use
Drug Combinations
Male
Mandible/cytology/physiology
Osteogenesis/drug effects/*physiology
Oxides/*metabolism
Rats
Rats, Wistar
Silicates/*metabolism
LA - eng
N1 - Faculty of Dentistry, University of São Paulo, Ribeirão Preto, São Paulo,
Brazil. cassionasc@forp.usp.br
PY - 2008
SN - 0968-4328 (Print)
SP - 868-74
T2 - Micron (Oxford, England : 1993)
VL - 39
Y2 - 10
ID - 14796
ER -
TY - JOUR
AB - In-situ forming implant formulations based on poly(lactic-co-glycolic acid)
(PLGA), acetyltributyl citrate (ATBC), minocycline HCl, N-methyl pyrrolidone (NMP)
and optionally hydroxypropyl methylcellulose (HPMC) were prepared and thoroughly
characterized in vitro. This includes electron paramagnetic resonance (EPR),
nuclear magnetic resonance (1H NMR), mass change and drug release
measurements under different conditions, optical microscopy, size exclusion
chromatography (SEC) as well as antibacterial activity tests using gingival
crevicular fluid samples from periodontal pockets of periodontitis patients. Based
on these results, deeper insight into the physico-chemical phenomena involved in
implant formation and the control of drug release could be gained. For instance,
the effects of adding HPMC to the formulations, resulting in improved implant
adherence and reduced swelling, could be explained. Importantly, the in-situ formed
implants effectively hindered the growth of bacteria present in the patients'
periodontal pockets. Interestingly, the systems were more effectively hindering the
growth of pathogenic bacterial strains (e.g., Fusobacterium nucleatum) than that of
strains with a lower pathogenic potential (e.g., Streptococcus salivarius). In
vivo, such a preferential action against the pathogenic bacteria can be expected to
give a chance to the healthy flora to re-colonize the periodontal pockets.
AN - rayyan-563560379
AU - Do, M. P.
AU - Neut, C.
AU - Metz, H.
AU - Delcourt, E.
AU - Siepmann, J.
AU - Mäder, K.
AU - Siepmann, F.
DO - 10.1016/j.ejpb.2015.05.018
acetyltributyl citrate
minocycline
polyglactin
resomer
unclassified drug
adult
aged
article
bacterial growth
clinical article
drug release
electron spin resonance
female
gel permeation chromatography
gingivitis
human
male
microscopy
nonhuman
periodontal pocket
periodontitis
physical chemistry
Streptococcus
swelling
tooth implant
Veillonella
LA - English
PY - 2015
SN - ["1873-3441", "0939-6411"]
SP - 273-283
ST - Mechanistic analysis of PLGA/HPMC-based in-situ forming implants for
T2 - Eur. J. Pharm. Biopharm.
TI - Mechanistic analysis of PLGA/HPMC-based in-situ forming implants for
VL - 94
ID - 13753
ER -
TY - JOUR
AN - rayyan-563561217
AU - Dobrenić, M.
AU - Cekić-Arambasin, A.
AU - Tomić, D.
IS - 2
cortisone
article
dentistry
periodontitis
LA - Serbian
PY - 1970
SN - 0001-7019
SP - 64-76
ST - Application of Terra-Cortril Gel in the treatment of inflammatory
paradontopathies
T2 - Primjena Terra-Cortril Gela u lijecenju upalnih parodontopatija.
TI - Application of Terra-Cortril Gel in the treatment of inflammatory
paradontopathies
VL - 5
ID - 14591
ER -
TY - JOUR
AB - Periodontitis is an inflammatory disease involving supportive structures of
the teeth which is seen universally in all groups, ethnicities, races and both
genders. Various antibacterial agents have been used effectively in the management
of periodontal infection. The effectiveness of mechanical debridement of plaque and
repeated topical and systemic administration of antibacterial agents are limited
due to the lack of accessibility to periodontopathic organisms in the periodontal
pocket. Local delivery of antimicrobials has been investigated for the possibility
of overcoming the limitations of conventional therapy. These products provide a
long-term, effective treatment at the site of infection at much smaller doses.
Prospective multicentre studies considering risk factors for disease progression
have to be designed to identify patients who may benefit the most from Local drug
delivery.
AN - rayyan-563560514
AU - Dodwad, V.
AU - Vaish, S.
AU - Mahajan, A.
AU - Chhokra, M.
IS - 4
KW - chitosan
clarithromycin
doxycycline
herbaceous agent
liposome
metronidazole
microsphere
minocycline
nanocapsule
nanoparticle
nanosphere
polyglactin
polyglycolic acid
tetracycline
tripolyphosphate
antimicrobial therapy
Campylobacter rectus
drug formulation
drug safety
emulsion
gel
human
in vitro study
medicinal plant
micelle
periodontics
periodontitis
review
scale up
tooth brushing
treatment duration
treatment planning
LA - English
PY - 2012
SN - 0975-1491
SP - 30-34
ST - Local drug delivery in periodontics: A strategic intervention
TI - Local drug delivery in periodontics: A strategic intervention
VL - 4
ID - 13888
ER -
TY - JOUR
AB - Background. Dental implant surgery has become routine practice for replacing
missing teeth. Little is known about the use of local antisepsis to control the
development of bacterial plaque and to facilitate healing, as current practice
guidelines do not address this issue. Objectives. The objectives of this study were
to describe antiseptic practices for implant surgery and to assess plaque control
at the operative site as well as the investigator's satisfaction. Material and
methods. This prospective, observational study conducted in 4 European countries
enrolled 911 adult patients receiving a single or multiple implant on the day of
inclusion. Any medication prescribed during the pre- or postoperative periods was
documented, particularly antibiotics, antiseptic mouthwashes and topical antiseptic
gels. At a follow-up visit, the presence of plaque was documented on teeth adjacent
to the implant and its extent determined using the Silness-Löe index. Results. Oral
antibiotics were prescribed prior to surgery in 53.8% of the patients. Antiseptic
mouthwashes were prescribed to patients (49.6-65.7%) according to country.
Following dental implant placement, 84.1-94.7% of patients were prescribed oral
antibiotics, 45.6-86.5% of patients were prescribed antiseptic mouthwash and 72.8-
100% of patients were prescribed an antiseptic gel. At the follow-up visit, plaque
was observed in 45.4% of the patients. The mean Silness-Löe plaque index was 0.7 or
0.8, indicating a low level of plaque accumulation. The Löe and Silness gingival
index was 0.6 or 0.7, which is consistent with a low level of gingival
inflammation. Conclusions. Use of antibiotics pre- and post-surgery is frequent in
implant surgery, despite it being discouraged in practice guidelines. Use of
antiseptic mouthwashes and topical antiseptic gels is widespread, although
treatment paradigms vary widely. Practice guidelines covering antisepsis provision
would be useful, since those products could be used as an alternative to
antibiotics to facilitate wound healing.
AN - rayyan-563560134
AU - Dominiak, M.
AU - Shuleva, S.
AU - Silvestros, S.
AU - Alcoforado, G.
DO - 10.17219/acem/115087
IS - 3
KW - tooth implant
antibiotic agent
antiinfective agent
beta lactam antibiotic
macrolide
mouthwash
adult
article
European
female
follow up
gingival index
gingivitis
human
job satisfaction
longitudinal study
male
observational study
plaque index
postoperative period
prescription
prophylactic surgical procedure
prospective study
LA - English
PY - 2020
SN - ["2451-2680", "1899-5276"]
SP - 355-363
ST - A prospective observational study on perioperative use of antibacterial
agents in implant surgery
T2 - Adv. Clin. Exp. Med.
TI - A prospective observational study on perioperative use of antibacterial
agents in implant surgery
VL - 29
ID - 13508
ER -
TY - JOUR
AB - In this work, chitosan (CS) decorated metronidazole (MTZ) microcapsules
(CS@MTZ) were synthesized and used as a cross-linker for the preparation of a
poly(vinyl alcohol) (PVA) injectable hydrogel by dynamic covalent bonding and ionic
interaction through a 4-carboxyphenylboronic acid bridge. The use of MTZ
microcapsules efficiently slowed down the release rate of the hydrophilic
antibiotic from the hydrogel matrix. Besides, the hydrophobicity of the
microcapsules endows the PVA@CS@MTZ hydrogel to be sticky to a substrate in wet
conditions, under a suggested mechanism of evicting the water boundary layer on the
substrate. The sustained release behavior endowed a prolonged bacteriostasis
ability of the hydrogel formulation for up to 14 days in vitro, and the bioadhesive
property as well as the injectability of the hydrogel benefited the topical
delivery of MTZ in periodontal pockets and exhibited desirable antibacterial
capacity in 1 week on the rat periodontitis model.
AN - rayyan-563562034
AU - Dong, Z. H.
AU - Sun, Y. N.
AU - Chen, Y. H.
AU - Liu, Y.
AU - Tang, C. H.
AU - Qu, X. Z.
DO - 10.1021/acsabm.9b00912
IS - 12
PY - 2019
SN - 2576-6422
SP - 5985-5994
ST - Injectable Adhesive Hydrogel through a Microcapsule Cross-Link for
Periodontitis Treatment
T2 - ACS APPLIED BIO MATERIALS
TI - Injectable Adhesive Hydrogel through a Microcapsule Cross-Link for
VL - 2
Y2 - 12 y3 - 16
ID - 15408
ER -
TY - JOUR
AB - Periodontitis caused by bacteria is the most common oral disease. In the face
of plaque formation, traditional scaling and antibiotic treatment can lead to gum
recession, drug resistance and other side effects. The nanoplatform of
multifunctional complex treatment is attractive for the treatment of periodontitis.
In this study, epigallocatechin gallate (EGCG) was loaded into gold nanoparticle-
modified hydrogels (E-Au@H) to achieve the synergistic functions of near-infrared
(NIR) photosensitization, bactericidal and periodontal tissue regeneration. E-Au@H
rapidly heats up to 50.7 degrees C within 5 min under NIR light irradiation,
exerting a good photothermal effect, while the NIR spectrum can effectively control
the release of tea polyphenols, enhance the antibacterial effect, promote
angiogenesis and improve bone regeneration. In vitro studies showed that NIR-
irradiated composites inhibited S. aureus, E. coli and S. aureus biofilms by 94 %,
92 % and 74 %, increased alkaline phosphatase activity 5-fold after 7 days and
increased extracellular matrix mineralization rate 3-fold after 21 days. The rat
periodontitis model successfully demonstrated that E-Au@H with NIR light
irradiation inhibited dental plaque biofilm by 87 % and promoted alveolar bone
regeneration by 38 %. The experimental results suggest that this hydrogel with a
NIR-sensitive composite nanoplatform offers new possibilities for the treatment of
periodontal disease. (c) 2022 The Authors. Published by Elsevier Ltd. This is an
open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/).
AN - rayyan-563562191
AU - Dong, Z. Q.
AU - Lin, Y. Y.
AU - Xu, S. B.
AU - Chang, L. N.
AU - Zhao, X. J.
AU - Mei, X. F.
AU - Gao, X. Q.
DO - 10.1016/j.matdes.2022.111487
PY - 2023
SN - ["0264-1275", "1873-4197"]
ST - NIR-triggered tea polyphenol-modified gold nanoparticles-loaded hydrogel
treats periodontitis by inhibiting bacteria and inducing bone regeneration
T2 - MATERIALS & DESIGN
TI - NIR-triggered tea polyphenol-modified gold nanoparticles-loaded hydrogel
VL - 225
Y2 - 1
ID - 15565
ER -
TY - JOUR
AN - rayyan-563561512
AU - Dong, Z.
AU - Lin, Y.
AU - Xu, S.
AU - Chang, L.
AU - Zhao, X.
AU - Mei, X.
AU - Gao, X.
DO - 10.1016/j.matdes.2022.111487
PY - 2023
ST - NIR-triggered tea polyphenol-modified gold nanoparticles-loaded hydrogel
T2 - Materials and Design
TI - NIR-triggered tea polyphenol-modified gold nanoparticles-loaded hydrogel
85146232272&doi=10.1016%2fj.matdes.2022.111487&partnerID=40&md5=55a6f9eaf126054e4c3
94f2d52ea1666
VL - 225
ID - 14886
ER -
TY - JOUR
AB - In this work, chitosan (CS) decorated metronidazole (MTZ) microcapsules
(CS@MTZ) were synthesized and used as a cross-linker for the preparation of a
poly(vinyl alcohol) (PVA) injectable hydrogel by dynamic covalent bonding and ionic
interaction through a 4-carboxyphenylboronic acid bridge. The use of MTZ
microcapsules efficiently slowed down the release rate of the hydrophilic
antibiotic from the hydrogel matrix. Besides, the hydrophobicity of the
microcapsules endows the PVA@CS@MTZ hydrogel to be sticky to a substrate in wet
conditions, under a suggested mechanism of evicting the water boundary layer on the
substrate. The sustained release behavior endowed a prolonged bacteriostasis
ability of the hydrogel formulation for up to 14 days in vitro, and the bioadhesive
property as well as the injectability of the hydrogel benefited the topical
delivery of MTZ in periodontal pockets and exhibited desirable antibacterial
capacity in 1 week on the rat periodontitis model.
AN - rayyan-563560163
AU - Dong, Z.
AU - Sun, Y.
AU - Chen, Y.
AU - Liu, Y.
AU - Tang, C.
AU - Qu, X.
DO - 10.1021/acsabm.9b00912
IS - 12
animal model
article
bacteriostasis
boundary layer
controlled study
covalent bond
cross linking
drug formulation
drug therapy
hydrophilicity
hydrophobicity
in vitro study
male
microcapsule
nonhuman
periodontal pocket
periodontitis
rat
adhesive agent
antibiotic agent
antiinfective agent
chitosan
hydrogel
metronidazole
microsphere
polyvinyl alcohol
water
LA - English
PY - 2019
SN - 2576-6422
SP - 5985-5994
ST - Injectable Adhesive Hydrogel through a Microcapsule Cross-Link for
T2 - ACS Appl Bio Mater
TI - Injectable Adhesive Hydrogel through a Microcapsule Cross-Link for
VL - 2
ID - 13537
ER -
TY - JOUR
AN - rayyan-563561753
AU - Donos, N.
AU - Calciolari, E.
AU - Brusselaers, N.
AU - Goldoni, M.
AU - Bostanci, N.
AU - Belibasakis, G. N.
DO - 10.1111/jcpe.13232
PY - 2020
SP - 199-238
ST - The adjunctive use of host modulators in non-surgical periodontal therapy. A
systematic review of randomized, placebo-controlled clinical studies
TI - The adjunctive use of host modulators in non-surgical periodontal therapy. A
systematic review of randomized, placebo-controlled clinical studies
85081337746&doi=10.1111%2fjcpe.13232&partnerID=40&md5=64fedf9a54d02874e3b4c25f8615b
8da
VL - 47
ID - 15127
ER -
TY - JOUR
AB - The aim of this study was to evaluate the abatement power of oral microbial
loading of a new gel formulation based on the complex silver-2-mercaptobenzoate,
chlorhexidine digluconate and didecyldimethylammonium chloride (named ADC) through
polymerase chain reaction (PCR). The study sample consists of a group of 20
patients with chronic periodontal disease. Patients were over 25 years of age and
did not undergo surgical or non-surgical periodontal treatment in the previous 6
months. The study sample was allotted into two groups of 10 patients each,
homogeneous by age and sex. The test group received a bottle containing ADC gel,
while the control group received an identical one containing placebo, similar to
ADC in consistence, colour, taste and odour. Sub-gingival samples of four sites,
one in each quadrant, of greatest probing depth in each patient were used.
Microbiological analyses were performed at baseline and at day 15. Paired t test
was performed to detect statistical significant reduction in total bacterial
loading and oral pathogens in the study groups. The analysis showed a statistically
significant reduction in the total bacterial loading evaluated pre- and post-
treatment (P = 0.029) in the study groups. In the control group, the decrease in
total bacterial loading was not significant (P = 0.279). Clinically, ADC gel does
not have any side effects and discomfort such as pain, burning, tingling sensation
or numbness and produces no adverse reactions in time. Our study aimed to evaluate
the efficacy of a new chemical formulation with antibacterial properties to use for
daily oral hygiene with a preliminary study. Our results showed a statistically
significant reduction in total bacterial loading after treatment, but the
limitations of our study do not allow us to demonstrate the clinical efficacy of
the ADC gel.
AN - rayyan-563561315
AU - Dorina, L.
AU - Annalisa, P.
AU - Ornella, D.
AU - Alessandro, B.
AU - Liliana, O.
AU - Marco, G.
AU - Di Girolamo, M.
AU - Valentina, C.
DO - 10.1177/2058738419868101
J2 - Int J Immunopathol Pharmacol
KW - Adult
Bacterial Load/methods
Chlorhexidine/administration & dosage/analogs & derivatives
Color
Female
Humans
Male
Oral Hygiene/methods
Periodontal Index
Quaternary Ammonium Compounds/administration & dosage
Silver/*administration & dosage
Surface-Active Agents/*administration & dosage
LA - eng
N1 - Department of Medicine and Surgery, Centre of Neuroscience of Milan,
University of Milan-Bicocca, Milan, Italy.; Department of Experimental, Diagnostic
and Specialty Medicine, University of Bologna, Bologna, Italy.; Maxillofacial and
Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan,
Italy.; Maxillofacial and Dental Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore
Policlinico, Milan, Italy.; Department of Biomedical, Surgical and Dental Sciences,
University of Milan, Milan, Italy.; Department of Clinical Sciences and
Translational Medicine, University of Rome Tor Vergata, Rome, Italy.; Department of
Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome,
Italy.; Department of Clinical Sciences and Translational Medicine, University of
Rome Tor Vergata, Rome, Italy.; Department of Biomedical, Surgical and Dental
Sciences, University of Milan, Milan, Italy.
PY - 2019
SP - 2058738419868101
ST - The use of a new chemical device based on silver and cationic surfactants as
a new approach for daily oral hygiene: A preliminary study on a group of
periodontal patients
T2 - International journal of immunopathology and pharmacology
TI - The use of a new chemical device based on silver and cationic surfactants as
VL - 33
Y2 - 1
ID - 14689
ER -
TY - JOUR
significant reduction in the total bacterial loading evaluated pre-and post-
the ADC gel.
AN - rayyan-563560214
AU - Dorina, L.
AU - Annalisa, P.
AU - Ornella, D.
AU - Alessandro, B.
AU - Liliana, O.
AU - Marco, G.
AU - Michele, D. G.
AU - Valentina, C.
DO - 10.1177/2058738419868101
KW - cationic surfactant
didecyldimethylammonium chloride
silver
silver 2 mercaptobenzoate
unclassified drug
adult
article
bacterial load
Candida albicans
chronic disease
clinical article
controlled study
Enterococcus hirae
Escherichia coli
gel
human
in vitro study
mouth hygiene
nonhuman
periodontal disease
priority journal
LA - English
PY - 2019
SN - ["2058-7384", "0394-6320"]
T2 - Int. J. Immunopathol. Pharmacol.
VL - 33
ID - 13588
ER -
TY - JOUR
AB - Background: Periodontitis is a chronic inflammatory disruption of the
periodontal supportive tissues. There are the numerous evidences for his bacterial
etiology. Though the occurrence of periodontal bacteria is considered to be the
main cause of periodontitis, certain characteristics of the individual immune
response may also have inûuence on the disease development and progression, and on
the treatment outcomes. There are some reports that attempt to identify genetic
factors associated with periodontitis including polymorphisms of interleukin-1 beta
(IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) genes. We
were interested from the distribution of several genotypes of the cytokines:
interleukin-6 - (G-174C) and (G-597A), lymphotoxin-α (A+252G), and tumour necrosis
factor-alpha (G-308A) in patients with chronic periodontitis. Aim: To investigate
the association of chronic periodontitis with certain gene polymorphisms of
interleukin-6 (IL-6), Lymphotoxin- α, and tumor necrosis factor-alpha (TNF-α).
Material and methods: The study included 30 patients with moderate or severe
chronic periodontitis, and 10 persons with healthy periodontium. Total genomic DNA
was extracted from the buccal epithelial cells. TNF-A (G-308A), IL-6 (G-174C), IL-6
(G-597A) and LT-A (A+252G) genes polymorphisms were analyzed by Polymerase chain
reaction (PCR). Results: Outcomes showed a large variety in genotype’s distribution
in the investigated groups. No important difference was observed in the
distribution of IL-6, TNF-α and LT-α genotypes between chronic periodontitis
patients and controls in this study be reason of the small studied group. However,
a signiûcant difference in the LT-α was observed – a prevalence of the genotype GG
in patients with severe periodontitis. In relation with IL-6 (G-597A) and IL- 6 (G-
174C) genotyping - in both of them in patients with severe periodontitis was
occurred most frequently the genotype GG. In patients with periodontitis the
frequency of genotype GG of TNF-α (G-308A) was significantly increased. Conclusion:
The assessment IL-6 (G-597A) and IL- 6 (G-174C), and TNF-α (G-308A) revealed that
genotype GG was moderate associated with chronic periodontitis in Bulgarian
individuals. As a result of these findings we may suppose that the G allele may
play an important role in the development and progression of periodontal disease in
this population. The frequency of LT-A (A252G) was significantly greater in severe
periodontitis patients in this study.
AN - rayyan-563560373
AU - Dosseva-Panova, V.
AU - Mlachkova, A.
AU - Popova, C.
AU - Kicheva, M.
DO - 10.5272/jimab.2015213.868
IS - 3
KW - interleukin 6
lymphotoxin
adult
allele
article
clinical article
controlled study
disease severity
gene frequency
genetic association
genetic polymorphism
genotype
human
immune response
osteolysis
prevalence
LA - English
PY - 2015
SN - 1312-773X
SP - 868-875
ST - Evaluation of interleukin-6, lymphotoxin- α and TNF-α gene polymorphisms in
T2 - J. IMAB Ann. Proc.
TI - Evaluation of interleukin-6, lymphotoxin- α and TNF-α gene polymorphisms in
VL - 21
ID - 13747
ER -
TY - JOUR
AB - In Porphyromonas gingivalis, the protein PG1660, composed of 174 amino acids,
is annotated as an extracytoplasmic function (ECF) sigma factor (RpoE homologue-
σ24). Because PG1660 can modulate several virulence factors and responds to
environmental signals in P. gingivalis, its genetic properties were evaluated.
PG1660 is co-transcribed with its downstream gene PG1659, and the transcription
start site was identified as adenine residue 54-nucleotides upstream of the ATG
translation start codon. In addition to binding its own promoter, using the
purified rPG1660 and RNAP core enzyme from Escherichia coli with the PG1660
promoter DNA as template, the function of PG1660 as a sigma factor was demonstrated
in an in vitro transcription assay. Transcriptome analyses of a P. gingivalis
PG1660-defective isogenic mutant revealed that under oxidative stress conditions
176 genes including genes involved in secondary metabolism were downregulated more
than two-fold compared with the parental strain. The rPG1660 protein also showed
the ability to bind to the promoters of the highly downregulated genes in the
PG1660-deficient mutant. As the ECF sigma factor PG0162 has a 29% identity with
PG1660 and can modulate its expression, the cross-talk between their regulatory
networks was explored. The expression profile of the PG0162PG1660-deficient mutant
(P. gingivalis FLL356) revealed that the type IX secretion system genes and several
virulence genes were downregulated under hydrogen peroxide stress conditions. Taken
together, we have confirmed that PG1660 can function as a sigma factor, and plays
an important regulatory role in the oxidative stress and virulence regulatory
network of P. gingivalis.
AN - rayyan-563560265
AU - Dou, Y.
AU - Rutanhira, H.
AU - Chen, X.
AU - Mishra, A.
AU - Wang, C.
AU - Fletcher, H. M.
DO - 10.1111/omi.12204
IS - 1
KW - ABC excinuclease
adenine
alpha mannosidase
bacterial DNA
bacterial enzyme
bacterial protein
bacterial RNA
carboxylase
coenzyme A ligase
complementary DNA
CRISPR associated protein
DNA fragment
DNA topoisomerase
DNA topoisomerase III
epimerase
glycosyltransferase
hydrogen peroxide
mandelate racemase
membrane protein
phosphoribosyltransferase
protein disulfide reductase (glutathione)
protein tyrosine kinase A
pyridine nucleotide disulphide oxidoreductase family protein
recombinant protein
RNA helicase
RNA ligase
sigma factor
sigma factor PG1660
transcriptome
unclassified drug
unindexed drug
article
bacterial gene
bacterial genetics
bacterial growth
bacterial secretion system
bacterial strain
bacterial virulence
bacterium culture
bacterium mutant
biofilm
comparative study
controlled study
cytoplasm
deletion mutant
DNA microarray
DNA template
down regulation
Escherichia coli
gene amplification
gene expression profiling
gene overexpression
in vitro study
nonhuman
oxidative stress
promoter region
protein binding
protein function
protein secondary structure
RNA sequence
secondary metabolism
start codon
transcription initiation site
transcription regulation
transcriptomics
translation regulation
type IX secretion system
upregulation
Western blotting
LA - English
PY - 2018
SN - ["2041-1014", "2041-1006"]
SP - 89-104
ST - Role of extracytoplasmic function sigma factor PG1660 (RpoE) in the oxidative
stress resistance regulatory network of Porphyromonas gingivalis
TI - Role of extracytoplasmic function sigma factor PG1660 (RpoE) in the oxidative
stress resistance regulatory network of Porphyromonas gingivalis
VL - 33
ID - 13639
ER -
TY - JOUR
AB - This article reviews the potential injectable polymeric biomaterial scaffolds
currently being investigated for application in bone tissue regeneration. Two types
of injectable biomaterial scaffolds are focused in this review, including
injectable microspheres and injectable gels. The injectable microspheres section
covers several polymeric materials, including poly(L-lactide-co-glycolide)-PLGA,
poly(propylene fumarate), and chitosan. The injectable gel section covers alginate
gels, hyaluronan hydrogels, poly(ethylene-glycol)-PEG hydrogels, and PEG-PLGA
copolymer hydrogels. This review focuses on the effect of cellular behavior in
vitro and in vivo in terms of material properties of polymers, such as
biodegradation, biocompatibility, porosity, microsphere size, and cross-linking
nature. Injectable polymeric biomaterials offer a major advantage for orthopedic
applications by allowing the ability to use noninvasive or minimally invasive
treatment methods. Therefore, combining injectable polymeric biomaterial scaffolds
with cells have a significant potential to treat orthopedic bone defects, including
spine fusion, and craniofacial and periodontal defects. © 2013 Wiley Periodicals,
Inc. J Biomed Mater Res Part A, 2013. Copyright © 2013 Wiley Periodicals, Inc.
AN - rayyan-563560475
AU - Dreifke, M. B.
AU - Ebraheim, N. A.
AU - Jayasuriya, A. C.
DO - 10.1002/jbm.a.34521
IS - 8
KW - alginic acid
biomaterial
chitosan
fumaric acid derivative
hyaluronic acid
hydroxyapatite
macrogol
microsphere
poly (propylene fumarate)
polyglactin
polymer
propylene glycol
unclassified drug
biocompatibility
biodegradation
bone regeneration
bone tissue
cell adhesion
cell function
cell viability
chemical structure
cross linking
gel
human
hydrogel
hydrophilicity
hydrophobicity
in vitro study
in vivo study
molecular weight
ossification
osteoblast
polymerization
porosity
review
static electricity
tissue engineering
LA - English
PY - 2013
SN - ["1549-3296", "1552-4965"]
SP - 2436-2447
ST - Investigation of potential injectable polymeric biomaterials for bone
regeneration
T2 - J. Biomed. Mater. Res. Part A
TI - Investigation of potential injectable polymeric biomaterials for bone
regeneration
VL - 101
ID - 13849
ER -
TY - JOUR
AB - Hemoglobin is essential for maintaining cellular bioenergetic homeostasis
through its ability to bind and transport oxygen to the tissues. Besides its
ability to transport oxygen, hemoglobin within erythrocytes plays an important role
in cellular signaling and modulation of the inflammatory response either directly
by binding gas molecules (NO, CO, and CO2) or indirectly by acting as their source.
Once hemoglobin reaches the extracellular environment, it acquires several
secondary functions affecting surrounding cells and tissues. By modulating the cell
functions, this macromolecule becomes involved in the etiology and pathophysiology
of various diseases. The up-to-date results disclose the impact of extracellular
hemoglobin on (i) redox status, (ii) inflammatory state of cells, (iii)
proliferation and chemotaxis, (iv) mitochondrial dynamic, (v) chemoresistance and
(vi) differenti-ation. This review pays special attention to applied biomedical
research and the use of non-vertebrate and vertebrate extracellular hemoglobin as a
promising candidate for hemoglobin-based oxygen carriers, as well as cell culture
medium additive. Although recent experimental settings have some limitations, they
provide additional insight into the modulatory activity of extracellular hemoglobin
in various cellular microenvironments, such as stem or tumor cells niches.
AN - rayyan-563559922
AU - Drvenica, I. T.
AU - Stančić, A. Z.
AU - Maslovarić, I. S.
AU - Trivanović, D. I.
AU - Ilić, V. L.
DO - 10.3390/biom12111708
IS - 11
KW - culture medium
bilirubin
carbon dioxide
carbon tetrachloride
carboxyhemoglobin
CD163 antigen
cisplatin
creatine kinase
deoxyhemoglobin
eculizumab
evolocumab
gamma interferon
gelatinase B
glutamate dehydrogenase
glutathione
haptoglobin
heme oxygenase 1
hemoglobin
hemoglobin F
hemoglobin variant
hydrocortisone
hydrogel
interleukin 1beta
interleukin 6
lipoteichoic acid
methemoglobin
nitric oxide
oxyhemoglobin
peroxisome proliferator activated receptor alpha
phosphatidylserine
proteasome inhibitor
RANTES
Thy 1 membrane glycoprotein
transforming growth factor beta1
von Willebrand factor
acute kidney failure
adipogenesis
adult respiratory distress syndrome
anemia
angiogenesis
animal cell
animal tissue
apoptosis
astrocyte
atherosclerosis
blood brain barrier
blood transfusion
bone development
bone mineralization
bone regeneration
brain hemorrhage
breast cancer
C2C12 cell line
capillary density
carotid atherosclerosis
cell function
cell proliferation
chemotaxis
chondrogenesis
corpus callosum
cryopreservation
cytokine release
disease severity
electroencephalography
encapsulation
erythrocyte
Escherichia coli
follow up
gene expression
glioblastoma
hematopoietic stem cell
hemoglobinopathy
hemolysis
homeostasis
human
human cell
human tissue
hydrophobicity
hypertension
hypoxia
inflammation
iron overload
knee meniscus rupture
liver toxicity
lysosome storage disease
macromolecule
melanoma
microangiopathy
mitochondrion
mouse
multiple myeloma
nanoemulsion
nitrosylation
nonhuman
oligodendrocyte precursor cell
osteoarthritis
osteoporosis
oxidative stress
paroxysmal nocturnal hemoglobinuria
pathophysiology
periodontal disease
periodontitis
phagocytosis
preeclampsia
protein assembly
proteinuria
rat
reperfusion injury
review
sickle cell anemia
signal transduction
spherocytosis
stem cell
subarachnoid hemorrhage
systematic review
thalassemia
tissue oxygenation
tissue regeneration
tumor cell
tumor growth
vascular smooth muscle cell
wound healing
LA - English
PY - 2022
SN - 2218-273X
ST - Extracellular Hemoglobin: Modulation of Cellular Functions and
Pathophysiological Effects
T2 - Biomolecules
TI - Extracellular Hemoglobin: Modulation of Cellular Functions and
Pathophysiological Effects
VL - 12
ID - 13296
ER -
TY - JOUR
AB - Bromodomain-containing protein 9 (BRD9), a component of non-canonical BAF
chromatin remodeling complex, has been identified as a critical therapeutic target
in hematological diseases. Despite the hematopoietic origin of osteoclasts, the
role of BRD9 in osteoclastogenesis and bone diseases remains unresolved. Here, we
show Brd9 deficiency in myeloid lineage enhances osteoclast lineage commitment and
bone resorption through downregulating interferon-beta (IFN-β) signaling with
released constraint on osteoclastogenesis. Notably, we show that BRD9 interacts
with transcription factor FOXP1 activating Stat1 transcription and IFN-β signaling
thereafter. Besides, function specificity of BRD9 distinguished from BRD4 during
osteoclastogenesis has been evaluated. Leveraging advantages of pharmacological
modulation of BRD9 and flexible injectable silk fibroin hydrogel, we design a local
deliver system for effectively mitigating zoledronate related osteonecrosis of the
jaw and alleviating acute bone loss in lipopolysaccharide-induced localized
aggressive periodontitis. Overall, these results demonstrate the function of BRD9
in osteoclastogenesis and its therapeutic potential for bone diseases.
AN - rayyan-563559679
AU - Du, J.
AU - Liu, Y.
AU - Wu, X.
AU - Sun, J.
AU - Shi, J.
AU - Zhang, H.
AU - Zheng, A.
AU - Zhou, M.
AU - Jiang, X.
DO - 10.1038/s41467-023-37116-5
IS - 1
KW - perimeter
beta interferon
bromodomain containing protein
bromodomain containing protein 9
cre recombinase
dexamethasone
gelatinase B
hydrogel
messenger RNA
silk fibroin
STAT1 protein
transcription factor FOXP1
unclassified drug
alveolar bone
alveolar bone loss
animal cell
animal experiment
animal model
article
bisphosphonate related osteonecrosis of the jaw
bone density
bone marrow cell
bone mass
bone mineralization
bone surface volume ratio
bone volume
bone volume fraction
cell count
cell lineage
chromatin assembly and disassembly
chromatin immunoprecipitation sequencing
controlled study
cortical thickness (bone)
corticosteroid therapy
distal femur
down regulation
female
gene ontology
human
human cell
hypothesis
interferon signaling
knockout mouse
lipopolysaccharide-induced inflammation
LoxP site
male
mouse
multinuclear cell
negative feedback
nonhuman
ossification
osteoclast
osteoclastogenesis
promoter region
protein deficiency
protein expression level
RAW 264.7 cell line
RNA sequencing
surface property
trabecular bone
trabecular number
trabecular separation
trabecular thickness
transcription initiation
transcription initiation site
upregulation
LA - English
PY - 2023
SN - 2041-1723
ST - BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through
negative feedback mechanism
T2 - Nat. Commun.
TI - BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through
negative feedback mechanism
VL - 14
ID - 13053
ER -
TY - JOUR
AB - Cl-amidine has been reported to have anti-inflammatory properties in a
variety of diseases. However, the role of Cl-amidine in periodontal disease remains
unclear. Here, the purpose of this study was to investigate the effect of Cl-
amidine on lipopolysaccharide (LPS)-induced inflammation in human gingival
fibroblasts (HGFs). The cytotoxic effect of Cl-amidine was measured with the Cell
Counting Kit-8 (CCK-8) assay and Annexin V-FITC/PI staining. The protein levels of
IL-6 and IL-8 in culture supernatants were measured with enzyme-linked
immunosorbent assay (ELISA). The mRNA levels of inflammatory cytokines, TLR4 and
MyD88 were assessed by quantitative real-time polymerase chain reaction (qRT-PCR)
analysis. The expression patterns of IL-6, TNF-ɑ, and IL-1β in HGFs were tested
with western blot. The levels of NF-κB, MAPK, and Nrf2 pathway-related proteins
were detected by western blot. Immunofluorescence (IF) staining was used to examine
the nuclear translocation of NF-κB p65. Moreover, a rat gingivitis model was
established to further clarify the role of Cl-amidine. Our results showed that Cl-
amidine suppressed LPS-induced gingival inflammation both in vitro and in vivo.
Mechanistically, Cl-amidine inhibited LPS-induced MyD88 expression, NF-κB
activation, and JNK phosphorylation. Additionally, Cl-amidine upregulated Nrf2 and
Ho-1 expression both with and without LPS stimulation but did not alter ROS levels
or Keap1 expression. Overall, our data suggest that Cl-amidine acts as an inhibitor
of LPS-induced gingival inflammation via the JNK/MAPK, NF-κB, and Nrf2 signalling
pathways.
AN - rayyan-563559758
AU - Du, J.
AU - Wang, N.
AU - Sun, H.
AU - Zheng, L.
AU - Qi, X.
DO - 10.1007/s13577-022-00822-1
IS - 1
ELISA kit
amidine
cytokine
interleukin 1beta
interleukin 6
interleukin 8
kelch like ECH associated protein 1
lipocortin 5
lipopolysaccharide
messenger RNA
transcription factor RelA
animal care
animal experiment
animal model
apoptosis rate
article
cell culture
cell proliferation
chemoluminescence
controlled study
cytokine production
cytotoxicity
fibroblast
flow cytometry
gene expression
immunofluorescence
in vitro study
in vivo study
male
MAPK signaling
nonhuman
Nrf2 signaling
protein expression
radioimmunoprecipitation
rat
RNA extraction
signal transduction
Western blotting
LA - English
PY - 2023
SN - ["1749-0774", "0914-7470"]
SP - 223-233
ST - Cl-amidine attenuates lipopolysaccharide-induced inflammation in human
gingival fibroblasts via the JNK/MAPK, NF-κB, and Nrf2 signalling pathways
T2 - Hum. Cell
TI - Cl-amidine attenuates lipopolysaccharide-induced inflammation in human
gingival fibroblasts via the JNK/MAPK, NF-κB, and Nrf2 signalling pathways
VL - 36
ID - 13132
ER -
TY - JOUR
AB - Tissue engineering-based endodontic therapies, designed to regenerate the
dental pulp (DP) in the devitalised endodontic space, have been proposed to improve
tooth longevity compared to conventional root-filling therapies. Their aim is to
restore tooth vitality and major DP functions necessary to maintain tooth health
such as immunosurveillance, sensitivity and healing/repair/regenerative capacities.
Several formulations based on the use of fibrin, the main component of the blood
clot matrix, recently gave valuable results in the regeneration of the human DP.
This review describes recent fibrin-based scaffolds designed for that purpose.
After having presented the various strategies for DP regeneration, the main fibrin-
based scaffolds reported so far for clinical use in endodontics were reviewed.
Particular emphasis was given to hydrogel devices that may be improved by
incorporation of bioactive molecules that stimulate vascularisation and tissue
neoformation or provide antibacterial properties. Data indicate that fibrin-based
scaffolds constitute a highly favourable environment for mesenchymal stem cells,
which is maintained upon functionalisation. Additional knowledge is needed to
understand how fibrin and functionalising agents affect adhesion, survival,
proliferation, migration and differentiation of cells incorporated in the scaffold
or which will colonise it from neighbouring host tissues. This knowledge is needed
to adapt the hydrogel formulation for various clinical conditions.
AN - rayyan-563562551
AU - Ducret, M.
AU - Costantini, A.
AU - Gobert, S.
AU - Farges, J. C.
AU - Bekhouche, M.
DO - 10.22203/eCM.v041a01
PY - 2021
SN - 1473-2262
SP - 1-14
ST - FIBRIN-BASED SCAFFOLDS FOR DENTAL PULP REGENERATION: FROM BIOLOGY TO
NANOTHERAPEUTICS
T2 - EUROPEAN CELLS & MATERIALS
TI - FIBRIN-BASED SCAFFOLDS FOR DENTAL PULP REGENERATION: FROM BIOLOGY TO
NANOTHERAPEUTICS
VL - 41
Y2 - 1
ID - 15925
ER -
TY - JOUR
AB - OBJECTIVE: This study is a proof of concept to determine the efficacy of a
custom-fabricated tray in placing antimicrobial and debriding agents in the
periodontal pockets of persons with active gingival infections. Localized
subgingival delivery of antimicrobial and antibiotic agents is routinely employed
as adjunctive therapy for the treatment and management ofperiopathogens associated
with periodontal disease. Because these delivery techniques often face time
constraints and impose temporary restrictions on patient brushing and flossing, a
custom-formed prescription dental tray can be used to deliver and maintain
medications in periodontal pockets between office visits and without brushing or
flossing restrictions. The ability of this tray to maintain sufficient
concentrations of medication in the periodontal pockets to have a therapeutic
effect is evaluated here with theoretical modeling and practical application.
METHODS: Hydrogen peroxide is an oral debriding agent and oral wound cleanser with
antimicrobial properties. The debriding effect of 1.7% hydrogen peroxide gel was
tested in vitro on Streptococcus mutans biofilm using glass carriers for
collection. Diffusion modeling tested the potential of the customized tray to place
hydrogen peroxide gel into the sulcus in the presence of crevicular fluid flow.
Changes in periodontal microflora with scanning electron microscopy analysis of in
vivo paper point site sampling were analyzed before and after a thin ribbon of 1.7%
hydrogen peroxide gel (approximately 0.7 gm) and a subtherapeutic dose (three
drops) of Vibramycin (50 mg/5 ml) were placed via Perio Trays into periodontal
pockets, ranging from 4-8 mm at daily prescribed intervals for two to five weeks.
RESULTS: In vitro results indicate that 1.7% hydrogen peroxide gel breaks down the
exopolysaccharide slime and cell walls ofS. mutans, and begins to debride the cells
from glass carriers within 10 minutes. Diffusion modeling indicates that hydrogen
peroxide can penetrate into the deeper pockets (9 mm), but also its concentration
in these deep pockets will increase over wearing time in the absence of degradation
by peroxidases and catalase. Site sampling data confirm diffusion modeling results,
with evidence that medication delivered with the prescription tray reduced
subgingival bacterial loads and enhanced healing of corresponding oral tissues.
CONCLUSION: The prescription Perio Tray effectively placed medication in the
gingival sulcus. Mathematical modeling indicated Perio Tray placement of hydrogen
peroxide gel in periodontal pockets with depths up to 9 mm over 15 minutes
treatment time was theoretically possible. Pathology reports reveal reductions in
subgingival bacterial loads and improvements in pretreatment pocket depths of up to
8 mm after 1.7% hydrogen peroxide and Vibramycin Syrup were prescribed for use with
the Perio Tray. The in vitro analysis indicating that hydrogen peroxide is the
active and effective oral debriding agent needs to be confirmed with additional
studies.
AN - rayyan-563561239
AU - Dunlap, T.
AU - Keller, D. C.
AU - Marshall, M. V.
AU - Costerton, J. W.
AU - Schaudinn, C.
AU - Sindelar, B.
AU - Cotton, J. R.
IS - 5
J2 - J Clin Dent
KW - Adult
Aged
Anti-Infective Agents/*administration & dosage
Bacteria/classification/drug effects
Biofilms/drug effects
Cell Wall/drug effects
Diffusion
Doxycycline/administration & dosage
Female
Gingival Crevicular Fluid/drug effects/microbiology
Gingival Hemorrhage/drug therapy/microbiology
Humans
Hydrogen Peroxide/administration & dosage
Male
Middle Aged
Models, Biological
Periodontal Pocket/*drug therapy/microbiology/pathology
Periodontics/*instrumentation
Polysaccharides, Bacterial/drug effects
Time Factors
LA - eng
N1 - Perio Protect LLC, St. Louis, MO, USA.
PY - 2011
SN - 0895-8831 (Print)
SP - 149-58
ST - Subgingival delivery of oral debriding agents: a proof of concept
T2 - The Journal of clinical dentistry
TI - Subgingival delivery of oral debriding agents: a proof of concept
VL - 22
ID - 14613
ER -
TY - JOUR
AB - Objective: This study is a proof of concept to determine the efficacy of a
custom-fabricated tray in placing antimicrobial and debriding agents in the
periodontal pockets of persons with active gingival infections. Localized
subgingival delivery of antimicrobial and antibiotic agents is routinely employed
as adjunctive therapy for the treatment and management of periopathogens associated
with periodontal disease. Because these delivery techniques often face time
constraints and impose temporary restrictions on patient brushing and flossing, a
custom-formed prescription dental tray can be used to deliver and maintain
medications in periodontal pockets between office visits and without brushing or
flossing restrictions. The ability of this tray to maintain sufficient
concentrations of medication in the periodontal pockets to have a therapeutic
effect is evaluated here with theoretical modeling and practical application.
Methods: Hydrogen peroxide is an oral debriding agent and oral wound cleanser with
antimicrobial properties. The debriding effect of 1.7% hydrogen peroxide gel was
tested in vitro on Streptococcus mutatis biofilm using glass carriers for
collection. Diffusion modeling tested the potential of the customized tray to place
hydrogen peroxide gel into the sulcus in the presence of crevicular fluid flow.
Changes in periodontal microflora with scanning electron microscopy analysis of in
vivo paper point site sampling were analyzed before and after a thin ribbon of 1.7%
hydrogen peroxide gel (approximately 0.7 gm) and a subtherapeutic dose (three
drops) of Vibramycin® (50 mg/5 ml) were placed via Perio Trays ® into periodontal
pockets, ranging from 4-8 mm at daily prescribed intervals for two to five weeks.
Results: In vitro results indicate that 1.7% hydrogen peroxide gel breaks down the
exopolysaccharide slime and cell walls of S. mutans, and begins to debride the
cells from glass carriers within 10 minutes. Diffusion modeling indicates that
hydrogen peroxide can penetrate into the deeper pockets (9 mm), but also its
concentration in these deep pockets will increase over wearing time in the absence
of degradation by peroxidases and catalase. Site sampling data confirm diffusion
modeling results, with evidence that medication delivered with the prescription
tray reduced subgingival bacterial loads and enhanced healing of corresponding oral
tissues. Conclusion: The prescription Perio Tray effectively placed medication in
the gingival sulcus. Mathematical modeling indicated Perio Tray placement of
hydrogen peroxide gel in periodontal pockets with depths up to 9 mm over 15 minutes
treatment time was theoretically possible. Pathology reports reveal reductions in
subgingival bacterial loads and improvements in pretreatment pocket depths of up to
8 mm after 1.7% hydrogen peroxide and Vibramycin Syrup were prescribed for use with
the Perio Tray. The in vitro analysis indicating that hydrogen peroxide is the
active and effective oral debriding agent needs to be confirmed with additional
studies.
AN - rayyan-563560572
AU - Dunlap, T.
AU - Keller, D. C.
AU - Marshall, M. V.
AU - William Costerton, J.
AU - Schaudinn, C.
AU - Sindelar, B.
AU - Cotton, J. R.
IS - 5
bacterial polysaccharide
doxycycline
hydrogen peroxide
adult
aged
article
bacterial load
bacterium
biofilm
biological model
cell wall
classification
diffusion
drug effect
female
gingiva bleeding
gingivitis
human
devices
male
microbiology
middle aged
pathology
periodontal pocket
periodontics
time
LA - English
PY - 2011
SN - 0895-8831
SP - 149-158
ST - Subgingival delivery of oral debriding agents: A proof of concept
T2 - J. Clin. Dent.
TI - Subgingival delivery of oral debriding agents: A proof of concept
VL - 22
ID - 13946
ER -
TY - JOUR
AB - Periodontal diseases are now one of the greatest challenges for modern
dentistry. Tooth loss impacts on systemic diseases in many patients. It seems
therefore that the treatment of chronic periodontitis is beneficial not only for
overall dental health but also for overall general health. Currently, the treatment
of periodontal diseases emphasizes a maximum of local treatment without systemic
complications. The creation of local drug carriers is of great importance and is
very useful in periodontic practice. Elimination of side effects from overall
treatment creates a good basis for long-term treatment especially in patients with
systemic diseases. However, the oral environment does not create favorable
conditions for topical pharmacotherapy. The continuous flow of saliva, cheek
movement, mealtimes, talking - all these factors make it difficult to maintain
medicine long enough on the mucosa or in the periodontal pocket. The application of
the medicine itself to the periodontal pocket is difficult; additionally, both the
ability to control the amount of medicine released and the medicine continuation
time in the pocket is often unpredictable. Modern pharmacology and biotechnology
are in search of new solutions and ways to deliver medicines topically. The popular
carriers of the past have now been abandoned due to the fact that they required
removal from the treated site after a few days. They caused a number of
disadvantages, e.g. periodontal tissue damage during application. Modern
mucoadhesive medicine carriers produced on the basis of hydrophilic compounds are
of particular interest. Several studies have demonstrated ease of application and
good retention in the pocket. © Wroclaw Medical University and Polish Dental
Society.
AN - rayyan-563560567
AU - Długoszowska-Szablewska, A.
AU - Zietek, M.
AU - Kida, D.
AU - Pluta, J.
IS - 4
KW - cytokine
drug carrier
metronidazole
polyacrylic acid
drug stability
electrospinning
gel
human
mouth cavity
mucosa
review
viscosity
elyzol
LA - ["English", "Polish"]
PY - 2012
SN - 1644-387X
SP - 583-587
ST - Overview of compounds that may be carriers of metronidazole used in topical
treatment of chronic periodontitis
T2 - Przegląd związków mogących być nośnikami metronidazolu stosowanego w
miejscowym leczeniu przewlekłego zapalenia przyzębia
TI - Overview of compounds that may be carriers of metronidazole used in topical
VL - 49
ID - 13941
ER -
TY - JOUR
AB - Replacing the lost teeth with the help of implants has become familiar and
popular among clinicians, which is due to high success rate and technical accuracy.
Peri implantitis is an inflammatory disease affecting the implant, thereby reducing
the survival in oral cavity, leading to failure. This literature discusses about
the various methods to treat peri-implantitis.
AN - rayyan-563560102
AU - Ebenezer, V.
AU - Ramalingam, B.
IS - 5
KW - dental curette
jet injector
silk suture
tooth implant
ultrasonic scaler
adrenalin plus lidocaine
calcium phosphate
enamel protein
hydrogel
hydroxyapatite
inert gas
titanium
adult
angiogenesis
biofilm
bleeding
bone development
bone graft
calcification
case report
cell proliferation
clinical article
cold atmospheric pressure air plasma jet treatment
female
fibrosis
histology
human
human tissue
jet injection
layer by layer deposition
male
middle aged
mouth cavity
periimplantitis
plasma
review
risk reduction
split thickness skin graft
suppuration
surgical approach
survival
suture removal
suture technique
tissue graft
treatment planning
LA - English
PY - 2020
SN - 2515-8260
SP - 1574-1575
ST - Treatment modalities of peri-implantitis - A review
TI - Treatment modalities of peri-implantitis - A review
VL - 7
ID - 13476
ER -
TY - JOUR
AB - Aim: To compare the results of administration of hyaluronic acid (HA) gel to
no gel administration following alveolar ridge preservation (ARP) in terms of
changes in wound dimensions over time. Materials and Methods: Systemically healthy
patients scheduled for ARP at one or two sites in the incisor, cuspid, or premolar
area with at least one neighbouring tooth and >50% buccal bone present following
extraction were included. ARP consisted of socket grafting with collagen-enriched,
deproteinized bovine bone mineral and socket sealing by means of a collagen matrix.
Following surgical therapy, sites were randomly allocated to the control group (no
gel application) or the test group (0.8% HA gel applied onto the collagen matrix
three times per day for 7 days). Bucco-lingual and mesio-distal wound dimensions
were registered at T0 (immediately post operation), T1 (1 week), and T2 (3 weeks).
Patient-reported outcomes, clinical outcomes, and hard and soft tissue changes were
recorded up to 4 months (T3). Results: In the control group, 20 patients (7 males,
13 females; mean age 53.30) with 23 sites, and in the test group 18 patients (9
males, 9 females; mean age 52.56) with 23 sites, were included. There were no
significant differences between the groups in the changes in wound dimensions from
T0 to T2 (bucco-lingual aspect: p =.340; mesio-distal aspect: p =.883). Three sites
(13%) in the control group and six (26%) in the test group demonstrated complete
wound resolution at T2 (p =.259). HA failed to show any effect on the number of
analgesics taken (p =.175), patient-reported outcomes (p ≥.263), alveolitis (p
=.136), socket healing (p ≥.424), soft tissue changes (p ≥.064), or mucosal
scarring (p =.548). However, significantly more horizontal bone loss at the coronal
aspect was found in the test group (p ≤.025). Conclusion: HA failed to promote
wound resolution on a collagen matrix. This study was registered in
ClinicalTrials.gov (NCT04467736).
AN - rayyan-563559893
AU - Eeckhout, C.
AU - Ackerman, J.
AU - Glibert, M.
AU - Cosyn, J.
DO - 10.1111/jcpe.13589
IS - 3
KW - NCT0446773
denture
orthodontic device
tooth implant
amoxicillin
analgesic agent
chlorhexidine
collagen
hyaluronic acid
ibuprofen
noradrenalin
perio aid
adult
alveolar bone
alveolar ridge
angiogenesis
article
bone mineral
bone regeneration
bone remodeling
bovine
canine tooth
controlled study
epithelization
extraction
female
finite element analysis
granulation tissue
human
human tissue
image analysis
incisor
molar tooth
mouth hygiene
osseointegration
osteitis
periodontal disease
postoperative pain
preservation
prevalence
remission
risk factor
soft tissue
tendon rupture
tissue graft
tooth disease
tooth extraction
topical anesthesia
trismus
wound healing
LA - English
PY - 2022
SN - ["1600-051X", "0303-6979"]
SP - 280-291
ST - A randomized controlled trial evaluating hyaluronic acid gel as wound healing
agent in alveolar ridge preservation
TI - A randomized controlled trial evaluating hyaluronic acid gel as wound healing
agent in alveolar ridge preservation
VL - 49
ID - 13267
ER -
TY - JOUR
AB - (1) Background: The standard treatment for periodontal disease, a chronic
inflammatory state caused by the interaction between biofilms generated by
organized oral bacteria and the local host defense response, consists of calculus
and biofilm removal through mechanical debridement, associated with antimicrobial
therapy that could be delivered either systemically or locally. The present study
aimed to determine the effectiveness of a hyaluronic acid membrane matrix as a
carrier for the controlled release of the active compounds of a formulation
proposed as a topical treatment for periodontal disease, and the influence of pH on
the complex system's stability. (2) Methods: The obtained hyaluronic acid (HA)
hydrogel membrane with dispersed melatonin (MEL), metronidazole (MZ), and
tetracycline (T) was completely characterized through FTIR, XRD, thermal analysis,
UV-Vis and fluorescence spectroscopy, fluorescence microscopy, zeta potential and
dielectric analysis. The MTT viability test was applied to check the cytotoxicity
of the obtained membranes, while the microbiological assessment was performed
against strains of Staphylococcus spp. and Streptococcus spp. The
spectrophotometric investigations allowed to follow up the release profile from the
HA matrix for MEL, MZ, and T present in the topical treatment considered. We
studied the behavior of the active compounds against the pH of the generated
environment, and the release profile of the bioactive formulation based on the
specific comportment towards pH variation. The controlled delivery of the bioactive
compounds using HA as a supportive matrix was modeled applying Korsmeyer-Peppas,
Higuchi, first-order kinetic models, and a newly proposed pseudo-first-order
kinetic model. (3) Results: It was observed that MZ and T were released at higher
active concentrations than MEL when the pH was increased from 6.75, specific for
patients with periodontitis, to a pH of 7.10, characterizing the healthy patients.
Additionally, it was shown that for MZ, there is a burst delivery up to 2.40 × 10(-
5) mol/L followed by a release decrease, while for MEL and T a short release
plateau was recorded up to a concentration of 1.80 × 10(-5) mol/L for MEL and 0.90
× 10(-5) mol/L for T, followed by a continuous release; (4) Conclusions: The
results are encouraging for the usage of the HA membrane matrix as releasing
vehicle for the active components of the proposed topical treatment at a
physiological pH.
AN - rayyan-563561107
AU - Eftimie Totu, E.
AU - Mănuc, D.
AU - Totu, T.
AU - Cristache, C. M.
AU - Buga, R. M.
AU - Erci, F.
AU - Cristea, C.
AU - Isildak, I.
DO - 10.3390/membranes12030303
IS - 3
J2 - Membranes (Basel)
LA - eng
N1 - Department of Analytical Chemistry and Environmental Engineering, University
Politehnica of Bucharest, 1-7 Polizu St., 011061 Bucharest, Romania.; Department of
Public Health, Faculty of Dental Medicine, "Carol Davila" University of Medicine
and Pharmacy, 8 Eroii Sanitari Blvd, 050474 Bucharest, Romania.; School of Life
Sciences, Ecole Polytechnique Fédèrale de Lausanne (EPFL), Route Cantonale, 1015
Lausanne, Switzerland.; Department of Dental Techniques, Faculty of Midwifery and
Nursing (FMAM), "Carol Davila" University of Medicine and Pharmacy, 8 Eroii
Sanitari Blvd, 050474 Bucharest, Romania.; School of Life Sciences, Ecole
Polytechnique Fédèrale de Lausanne (EPFL), Route Cantonale, 1015 Lausanne,
Switzerland.; Department of Biotechnology, Faculty of Science, Necmettin Erbakan
University, Yeni Meram Boulevard Kasim Halife Street, Meram, Konya 42090, Turkey.;
Biotechnologies Center, University of Agriculture and Veterinary Medicine, 42 Blvd.
Mărăşti, 011464 Bucharest, Romania.; Department of Bioengineering, Yildiz Campus
Barbaros Bulvari, Yildiz Technical University, Istanbul 34343, Turkey.
PY - 2022
SN - 2077-0375 (Print)
ST - Considerations on the Controlled Delivery of Bioactive Compounds through
Hyaluronic Acid Membrane
T2 - Membranes
TI - Considerations on the Controlled Delivery of Bioactive Compounds through
VL - 12
Y2 - 3 y3 - 8
ID - 14481
ER -
TY - JOUR
AB - The purpose of this review is to examine the latest literature on the use of
autologous platelet-rich fibrin as a drug and growth factor carrier system in
maxillofacial surgery. Autologous platelet-rich fibrin (PRF) is a unique system
that combines properties such as biocompatibility and biodegradability, in addition
to containing growth factors and peptides that provide tissue regeneration. This
opens up new horizons for the use of all beneficial ingredients in the blood sample
for biomedical purposes. By itself, PRF has an unstable effect on osteogenesis:
therefore, advanced approaches, including the combination of PRF with materials or
drugs, are of great interest in clinics. The main advantage of drug delivery
systems is that by controlling drug release, high drug concentrations locally and
fewer side effects within other tissue can be achieved. This is especially
important in tissues with limited blood supply, such as bone tissue compared to
soft tissue. The ability of PRF to degrade naturally is considered an advantage for
its use as a "warehouse " of controlled drug release systems. We are focusing on
this concentrate, as it is easy to use in manipulations and can be delivered
directly to the surgical site. The target audience for this review are researchers
and medical doctors who are involved in the development and research of PRFs
further studies. Likewise, surgeons who use PRF in their work to treat patients and
who advice patients to take the medicine orally.
AN - rayyan-563562641
AU - Egle, K.
AU - Salma, I.
AU - Dubnika, A.
DO - 10.3390/ijms222111553
IS - 21
PY - 2021
SN - 1422-0067
ST - From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be
Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release
TI - From Blood to Regenerative Tissue: How Autologous Platelet-Rich Fibrin Can Be
Combined with Other Materials to Ensure Controlled Drug and Growth Factor Release
VL - 22
Y2 - 11
ID - 16015
ER -
TY - JOUR
AB - This study explored the antibacterial activity of oral medicines utilized by
indigenous peoples of East and North Kalimantan. We have selected ten medicinal
plants commonly used in everyday life by the natives. We screened the samples using
antimicrobial assays and GTase inhibition activity, then isolated, identified, and
elucidated the mechanisms using HPLC, p-HPLC, NMR and MALDI TOF MASS. We obtained
the most effective sample, Garcinia parvifolia, as antimicrobial activity against
Streptococcus sobrinus and Porphyromonas gingivalis, with MIC values of 0.5 mg/ml
inhibition on both bacteria and MBC values of 0.5 and 1 mg/ml, respectively.
Methanol extract of G. parvifolia leaves showed antimicrobial activity in MIC and
MBC assays with activity guide fractionation. The components were then determined
using NMR and Maldi-Tof Mass techniques after being isolated with silica gel and
purified with PHPLC. We found garcidepsidone A (1) and garcidepsidone B (2) as
active compounds. MIC (2) for S. sobrinus was 0.02 mg/ml and for P. gingivalis was
0.05 mg/ml, but on the other hand, Garcidepsidone A (1) can inhibit GTase with a
value of 25%. Based on these results, we validated that the leaf extract that has
been used by the indigenous people of East and North Kalimantan could inhibit
bacteria from oral pathogens and reduce dental caries. Graphical Abstract: [Figure
not available: see fulltext.].
AN - rayyan-563559686
AU - Egra, S.
AU - Kuspradini, H.
AU - Kusuma, I. W.
AU - Batubara, I.
AU - Yamauchi, K.
AU - Mitsunaga, T.
DO - 10.1007/s00044-023-03071-5
IS - 8
KW - antibacterial activity
article
controlled study
dental caries
fractionation
Garcinia
human
indigenous people
infectious agent
medicinal plant
nonhuman
periodontal disease
plant leaf
stomatology
4alpha glucanotransferase
antiinfective agent
endogenous compound
methanol
plant extract
silica gel
LA - English
PY - 2023
SN - ["1554-8120", "1054-2523"]
SP - 1658-1665
ST - Garcidepsidone B from Garcinia parvifolia: antimicrobial activities of the
medicinal plants from East and North Kalimantan against dental caries and
periodontal disease pathogen
T2 - Med. Chem. Res.
TI - Garcidepsidone B from Garcinia parvifolia: antimicrobial activities of the
medicinal plants from East and North Kalimantan against dental caries and
periodontal disease pathogen
VL - 32
ID - 13060
ER -
TY - JOUR
AB - OBJECTIVES: The purpose of this in vitro study was to determine the
antimicrobial activity of two different taurolidine gel formulations in comparison
with minocycline microspheres. METHODS: Three percent taurolidine gel (TLG3) and 2
% taurolidine gel (TLG2) were compared to minocycline microspheres (MINO) against
single bacterial species and a 12-species-mixture. The antimicrobial activity was
proven by determination of minimal inhibitory concentrations (MICs), killing
assays, after exposure of the antimicrobials as well as within a biofilm. RESULTS:
The MICs against the single species were between 0.5 and 2 mg/ml of taurolidine.
MICs of the used mixed microbiota were 1.5 mg/ml (TLG3) and 4 mg/ml (TLG2).
Fusobacterium nucleatum and Porphyromonas gingivalis were completely killed by 10 %
TLG3 and TLG2 (equivalent to 3 and 2 mg/ml taurolidine) after 6 h. The mixture of
12 species was not completely killed by any of the test substances. Taurolidine
gels showed a post-antimicrobial activity, however being less than that of MINO. On
biofilms, taurolidine gels reduced concentration dependently the colony forming
unit (CFU) counts (multi-species biofilms by 3.63 log10 after 100 % (30 mg/ml) of
TLG3), reductions were 2.12 log10 after MINO (1000 μg/ml minocycline). CONCLUSIONS:
Taurolidine gel formulations exert antimicrobial activity against bacteria
associated with periodontal disease. Nevertheless, a complete elimination of
biofilms seems to be impossible and underlines the importance of mechanical removal
of biofilms prior to application of the antimicrobial. CLINICAL RELEVANCE:
Taurolidine gels may represent a potential alternative for adjunctive topical
antimicrobial treatment in periodontitis and infectious peri-implant diseases.
AN - rayyan-563560347
AU - Eick, S.
AU - Gloor, N.
AU - Püls, C.
AU - Zumbrunn, J.
AU - Sculean, A.
DO - 10.1007/s00784-015-1549-6
IS - 3
gel
microsphere
minocycline
taurine
taurolidine
thiadiazine derivative
bacterial count
bacterium
biofilm
drug effect
in vitro study
microbial sensitivity test
microbiology
periodontitis
LA - English
PY - 2016
SN - 1436-3771
SP - 597-606
ST - In vitro activity of taurolidine gel on bacteria associated with
periodontitis
TI - In vitro activity of taurolidine gel on bacteria associated with
periodontitis
VL - 20
ID - 13721
ER -
TY - JOUR
AB - The purpose of this in vitro study was to determine the antimicrobial
activity of two different taurolidine gel formulations in comparison with
minocycline microspheres. Three percent taurolidine gel (TLG3) and 2 % taurolidine
gel (TLG2) were compared to minocycline microspheres (MINO) against single
bacterial species and a 12-species-mixture. The antimicrobial activity was proven
by determination of minimal inhibitory concentrations (MICs), killing assays, after
exposure of the antimicrobials as well as within a biofilm. The MICs against the
single species were between 0.5 and 2 mg/ml of taurolidine. MICs of the used mixed
microbiota were 1.5 mg/ml (TLG3) and 4 mg/ml (TLG2). Fusobacterium nucleatum and
Porphyromonas gingivalis were completely killed by 10 % TLG3 and TLG2 (equivalent
to 3 and 2 mg/ml taurolidine) after 6 h. The mixture of 12 species was not
completely killed by any of the test substances. Taurolidine gels showed a post-
antimicrobial activity, however being less than that of MINO. On biofilms,
taurolidine gels reduced concentration dependently the colony forming unit (CFU)
counts (multi-species biofilms by 3.63 log10 after 100 % (30 mg/ml) of TLG3),
reductions were 2.12 log10 after MINO (1000 mu g/ml minocycline). Taurolidine gel
formulations exert antimicrobial activity against bacteria associated with
periodontal disease. Nevertheless, a complete elimination of biofilms seems to be
impossible and underlines the importance of mechanical removal of biofilms prior to
application of the antimicrobial. Taurolidine gels may represent a potential
alternative for adjunctive topical antimicrobial treatment in periodontitis and
infectious peri-implant diseases.
AN - rayyan-563562039
AU - Eick, S.
AU - Gloor, N.
AU - Puls, C.
AU - Zumbrunn, J.
AU - Sculean, A.
DO - 10.1007/s00784-015-1549-6
IS - 3
PY - 2016
SN - ["1432-6981", "1436-3771"]
SP - 597-606
ST - In vitro activity of taurolidine gel on bacteria associated with
periodontitis
TI - In vitro activity of taurolidine gel on bacteria associated with
periodontitis
VL - 20
Y2 - 4
ID - 15413
ER -
TY - JOUR
AB - Background: The study is designed to determine the effect on clinical
variables, subgingival bacteria, and local immune response brought about by
application of hyaluronan-containing gels in early wound healing after scaling and
root planing (SRP). Methods: In this randomized clinical study, data from 34
individuals with chronic periodontitis were evaluated after full-mouth SRP. In the
test group (n = 17), hyaluronan gels in two molecular weights were additionally
applied during the first 2 weeks after SRP. The control group (n = 17) was treated
with SRP only. Probing depth (PD) and clinical attachment level (CAL) were recorded
at baseline and after 3 and 6 months, and subgingival plaque and sulcus fluid
samples were taken for microbiologic and biochemical analysis. Results: In both
groups, PD and CAL were significantly reduced (P<0.001). The changes in PD and the
reduction of the number of pockets with PD ≥5 mm were significantly higher in the
test group after 3 (P = 0.014 and 0.021) and 6 (P = 0.046 and 0.045) months. Six
months after SRP, the counts of Treponema denticola were significantly reduced in
both groups (both P = 0.043), as were those of Campylobacter rectus in the test
group only (P= 0.028). Prevotella intermedia and Porphyromonas gingivalis increased
in the control group. Conclusion: The adjunctive application of hyaluronan may have
positive effects on PD reduction and may prevent recolonization by
periodontopathogens.
AN - rayyan-563560477
AU - Eick, S.
AU - Renatus, A.
AU - Heinicke, M.
AU - Pfister, W.
AU - Stratul, S. I.
AU - Jentsch, H.
DO - 10.1902/jop.2012.120269
IS - 7
hyaluronic acid
viscosupplement
adult
aged
article
bacterial load
Bacteroides
chemistry
comparative study
controlled study
drug effect
female
follow up
gel
gingivitis
human
male
methodology
microbiology
middle aged
molecular weight
periodontal disease
periodontal pocket
physiology
prospective study
tooth plaque
Treponema denticola
wound healing
LA - English
PY - 2013
SN - 0022-3492
SP - 941-949
ST - Hyaluronic acid as an adjunct after scaling and root planing: A prospective
randomized clinical trial
TI - Hyaluronic acid as an adjunct after scaling and root planing: A prospective
VL - 84
ID - 13851
ER -
TY - JOUR
AN - rayyan-563561964
AU - Eick, S.
AU - Schmitt, A.
AU - Sachse, S.
AU - Schmidt, K. H.
AU - Pfister, W.
DO - 10.1093/jac/dkh354
IS - 2
PY - 2004
SP - 553-556
ST - In vitro antibacterial activity of fluoroquinolones against Porphyromonas
gingivalis strains
T2 - Journal of Antimicrobial Chemotherapy
TI - In vitro antibacterial activity of fluoroquinolones against Porphyromonas
gingivalis strains
4444227633&doi=10.1093%2fjac
%2fdkh354&partnerID=40&md5=07e12b8336ce23c6677d0e8c763aae6e
VL - 54
ID - 15338
ER -
TY - JOUR
AB - AIM: Evaluation of the clinical effect of topical application of doxycycline
adjunctive to non-surgical periodontal therapy. METHODS: A total of 111 patients
suffering from untreated or recurrent moderate to severe periodontitis at 3
different centers (Heidelberg, Frankfurt, Nijmegen) were treated in this double-
blind split-mouth study. In each patient, 3 different treatment modalities were
assigned randomly to 3 test teeth: scaling and root planing alone (SRP), SRP with
subgingival vehicle control (VEH), and SRP with subgingival application of a newly
developed biodegradable 15% doxycycline gel (DOXI). At baseline, clinical
parameters were measured at all single rooted teeth using a reference splint: PlI,
PPD, relative attachment level (RAL-V), GI. 3 strata were generated according to
baseline PPD: (i) 5-6 mm, (ii) 7-8 mm, (iii) > or =9 mm. Not more than 50% active
smokers were allowed to each stratum. 3 and 6 months after therapy re-examination
was performed by examiners blinded to baseline data and test sites. The statistical
comparison of RAL-V gain and PPD reduction between the treatments was based on a
repeated measures ANOVA with correction according to Huynh & Feldt. The comparison
of SRP versus DOXI was considered as the main study question. RESULTS: 110 patients
finished the 3 months and 108 the 6 months examination. The study did not show
adverse effects of VEH or DOXI except for one singular inflammation that occurred 2
months after application of the doxycycline gel. DOXI provided statistically
significantly more favorable PPD reduction (SRP: -2.4+/-1.4 mm, VEH: -2.7+/-1.6 mm,
DOXI: -3.1+/-1.2 mm; SRP versus DOXI p=0.0001, VEH versus DOXI p=0.0066) and RAL-V
gain (SRP: 1.6+/-1.9 mm, VEH: 1.6+/-2.2 mm, DOXI: 2.0+/-1.7 mm; SRP versus DOXI
p=0.027, VEH versus DOXI p=0.038) than SRP and VEH after 6 months. CONCLUSIONS:
Adjunctive topical subgingival application of a biodegradable 15% doxycycline gel
was safe and provided more favorable RAL-V gain and PPD reduction than SRP alone
and VEH. Thus, by use of topical doxycycline the threshold for surgical periodontal
therapy might be moved toward deeper pockets.
AN - rayyan-563560914
AU - Eickholz, P.
AU - Kim, T. S.
AU - Bürklin, T.
AU - Schacher, B.
AU - Renggli, H. H.
AU - Schaecken, M. T.
AU - Holle, R.
AU - Kübler, A.
AU - Ratka-Krüger, P.
IS - 2
doxycycline
drug vehicle
adult
aged
article
clinical trial
comparative study
controlled study
female
follow up
gel
human
male
middle aged
multicenter study
periodontal disease
periodontics
periodontitis
reproducibility
sample size
smoking
tooth plaque
vehicles
LA - English
PY - 2002
SN - 0303-6979
SP - 108-117
ST - Non-surgical periodontal therapy with adjunctive topical doxycycline: a
double-blind randomized controlled multicenter study
TI - Non-surgical periodontal therapy with adjunctive topical doxycycline: a
double-blind randomized controlled multicenter study
VL - 29
ID - 14288
ER -
TY - JOUR
AB - Purpose: To evaluate the clinical effects of topical subgingival application
of a doxycycline gel compared to conventional mechanical debridement in supportive
periodontal therapy. Methods: 37 patients with residual or recurring periodontitis
after systematic periodontal treatment at two centers (Heidelberg, Frankfurt)
participated in this study. They had to exhibit at least one single-rooted tooth
with either a probing depth (PPD) = 5 mm and bleeding-on-probing (BOP) or with PPD
≥ 6 mm. The patients were randomly assigned to one of the two different treatment
regimes: DOXY (exclusively subgingival application of a 14% doxycycline gel) or SRP
(scaling and root planing with a sonic sealer). Clinical examinations (plaque index
[PII], PPD, vertical relative attachment level [RAL-V], gingival index [GI]) were
performed before, 3, and 6 months after therapy. Results: In 37 patients (19
female), aged 30-76 years with a total of 168 teeth were treated (DOXY: 79; SRP:
89). Six months after therapy, both groups exhibited statistically significant (P<
0.001) reductions of PPD (DOXY: -1.43±0.22 mm; SRP: -1.14±0.18 mm) and gains of
RAL-V (DOXY: 0.79±0.22 mm; SRP: 0.72±0.19 mm). Multilevel regression analyses,
considering the therapy of different numbers of teeth in different patients, failed
to show statistically significant differences concerning PPD reduction and RAL-V
gain between both therapies (DOXY/SRP). For both therapies, PPD reduction was
significantly better in deeper pockets (PPD≥ 7 mm) than in shallow pockets (PPD: 5-
6 mm).
AN - rayyan-563560779
AU - Eickholz, P.
AU - Kim, T. S.
AU - Schacher, B.
AU - Reitmeir, P.
AU - Bürklin, T.
IS - 6
doxycycline
adult
article
clinical trial
comparative study
controlled study
debridement
epidemiology
female
human
male
methodology
microbiology
multicenter study
periodontitis
LA - English
PY - 2005
SN - 0894-8275
SP - 341-346
ST - Subgingival topical doxycycline versus mechanical debridement for supportive
periodontal therapy: A single blind randomized controlled two-center study
T2 - Am. J. Dent.
TI - Subgingival topical doxycycline versus mechanical debridement for supportive
periodontal therapy: A single blind randomized controlled two-center study
VL - 18
ID - 14153
ER -
TY - JOUR
AB - Aim. This study aimed to evaluate the antibacterial effect of sodium
hypochlorite gel and four types of intracanal medicaments. Materials and Methods.
The agar diffusion method was used to evaluate the antibacterial effect of five
medicaments (sodium hypochlorite gel (NaOCl), chlorhexidine gel (CHX), calcium
hydroxide paste (CH), Ledermix, and Diapex plus) against Enterococcus faecalis (E.
faecalis), Staphylococcus aureus (S. aureus), and Escherichia coli (E. coli). The
zone of inhibition around each medicament was measured in millimeters, after 48
hours of incubation at 37 degrees C. The antibacterial effects of medicaments
against each microbial strain and the sensitivity of microorganisms towards each
medicament were compared using the one-way ANOVA and Games-Howell post hoc tests.
The level of significance was set to p<0.05. Results. All medicaments showed
variable inhibition zones for all bacterial strains except Diapex Plus which showed
no antibacterial activity. NaOCl gel exhibited the most significant inhibition
zones for all bacterial strains followed by CHX gel, Ledermix, and CH. However, the
effect of CHX and CH paste against S. aureus was statistically similar, while the
effect of CH against E. faecalis was significantly higher than the Ledermix.
Conclusion. Sodium hypochlorite gel displayed the highest antibacterial activity
among tested medicaments and can be recommended as a potent intracanal medicament.
Chlorhexidine gel showed a significantly higher antibacterial effect when compared
with Ledermix and calcium hydroxide. Calcium hydroxide demonstrated stronger
antibacterial activity against E. faecalis than Ledermix. Diapex Plus exhibited no
antibacterial effect.
AN - rayyan-563562405
AU - El Sayed, M.
AU - Ghanerad, N.
AU - Rahimi, F.
AU - Shabanpoor, M.
AU - Shabanpour, Z.
DO - 10.1155/2020/6483026
PY - 2020
SN - ["1687-8728", "1687-8736"]
ST - Antibacterial Activity of Sodium Hypochlorite Gel versus Different Types of
Root Canal Medicaments Using Agar Diffusion Test: An In Vitro Comparative Study
T2 - INTERNATIONAL JOURNAL OF DENTISTRY
TI - Antibacterial Activity of Sodium Hypochlorite Gel versus Different Types of
Root Canal Medicaments Using Agar Diffusion Test: An In Vitro Comparative Study
VL - 2020
Y2 - 11 y3 - 28
ID - 15779
ER -
TY - JOUR
AB - This review summarizes the four processes of wound healing in the human body
(hemostasis, inflammatory, proliferation, and remodeling) and the most current
research on the most important factors affecting cutaneous wound healing and the
underlying cellular and/or molecular pathways. Local factors, including
temperature, oxygenation, and infection, and systemic factors, such as age,
diabetes, sex hormones, genetic components, autoimmune diseases, psychological
stress, smoking and obesity are also addressed. A better understanding of the role
of these factors in wound repair could result in the development of therapeutics
that promote wound healing and resolve affected wounds. Additionally, natural
products obtained from plants and animals are critical targets for the discovery of
novel biologically significant pharmacophores, such as medicines and agrochemicals.
This review outlines the most recent advances in naturally derived targeted
treatment for wound healing. These are plant-derived natural products, insect-
derived natural products, marine-derived natural products, nanomaterial-based
wound-healing therapeutics (metal- and non-metal-based nanoparticles), and natural
product-based nanomedicine to improve the future direction of wound healing.
Natural products extracted from plants and animals have advanced significantly,
particularly in the treatment of wound healing. As a result, the isolation and
extraction of bioactive compounds from a variety of sources can continue to advance
our understanding of wound healing. Undescribed bioactive compounds or unexplored
formulations that could have a role in today's medicinal arsenal may be contained
in the abundance of natural products and natural product derivatives.
AN - rayyan-563559976
AU - El-Ashram, S.
AU - El-Samad, L. M.
AU - Basha, A. A.
AU - El Wakil, A.
DO - 10.1016/j.phrs.2021.105749
KW - acaricide
agricultural chemical
apamin
bee venom
catalase
chitosan
chrysin
curcumin
galangin
gelatinase A
glibenclamide
glutathione
gold nanoparticle
graphene
herbaceous agent
hyaluronic acid
hydrogel
hydroxyproline
kaempferol
lipoxygenase
luteolin
metal nanoparticle
methylglyoxal
microRNA
nanocomposite
nanofiber
nanoparticle
natural product
netilmicin
nonmetal
oleic acid
pectin
plasmin
polyvinyl alcohol
quercetin
salicylic acid
saponin
sericin
sex hormone
silver nanoparticle
sunscreen
vasculotropin
Aloe vera
anemia
angiogenesis
antifungal activity
antiphospholipid syndrome
antiviral activity
aquatic environment
autoimmune disease
biocompatibility
biodegradability
cell migration
cell proliferation
cytokine production
cytotoxicity
debridement
depression
diabetes mellitus
diabetic foot
diabetic neuropathy
Down syndrome
drug formulation
drug release
dyspepsia
enzyme activity
episiotomy
epithelization
Escherichia coli
extraction
female
gangrene
gingivitis
glucose blood level
glycosylation
granulation tissue
hemostasis
hermaphrodite
honeybee
human
hyperglycemia
hyperoxia
hypertension
hyperthermia
hypoxia
inflammation
insect
Klinefelter syndrome
macrophage migration
male
mental stress
molecularly targeted therapy
mouse
myofibroblast
nanomedicine
nonhuman
obesity
osteolysis
osteomyelitis
oxidative stress
oxygenation
phagocytosis
pharmacophore
quorum sensing
rat
review
sepsis
sickle cell anemia
signal transduction
skin injury
skin irritation
skin water loss
smoking
surface plasmon resonance
thrombocyte aggregation
tissue engineering
tissue regeneration
tonsillectomy
vagina flora
virus replication
wound dehiscence
wound healing
wound infection
LA - English
PY - 2021
SN - ["1096-1186", "1043-6618"]
ST - Naturally-derived targeted therapy for wound healing: Beyond classical
strategies
T2 - Pharmacol. Res.
TI - Naturally-derived targeted therapy for wound healing: Beyond classical
strategies
VL - 170
ID - 13350
ER -
TY - JOUR
AB - Background: This clinical study aimed to overcome the difficulty of graft
fixation and limited blood supply for dehiscence defects regeneration by using a
cross-linked gelfoam matrix jointly with collagen membrane and xenograft. Materials
and Methods: The study included twenty dehiscence-like defects in maxillary
anterior teeth with ≥4 mm facial bone loss and ≥5 mm clinical attachment loss (CAL)
in patients suffering from Stage III periodontitis. Sites were treated with
regenerative surgery using a cross-linked gelfoam matrix with glutaraldehyde,
xenograft, and collagen membrane. The recorded parameters were: CAL, probing pocket
depth (PPD), and radiographic three-dimensional (3D) volume for dehiscence-like
defects (3D volume of facial bone defects) and 3D volume of interproximal defects
using cone-beam radiographs. Data of these parameters were collected at both
baseline and 6 months postsurgery. 'Paired t-test' was used to assess the two
variables.' Results: Both CAL and PPD showed statistically significant reductions
and there was a significant bone gain at 6 months postsurgery in comparison to
baseline (P ≤ 0.05). Conclusion: Using a cross-linked gelfoam matrix with
glutaraldehyde in combination with xenograft and collagen membrane could enhance
the outcome of periodontal regeneration, especially in the treatment of challenging
dehiscence defects.
AN - rayyan-563559779
AU - Elboraey, M. O.
AU - Gamal, S. M.
DO - 10.4103/jisp.jisp_312_22
IS - 3
KW - cone beam computed tomography scanner
cross linked gelfoam matrix
dental tissue regeneration membrane
periodontal dressing
amoxicillin plus clavulanic acid
chlorhexidine
gelfoam
glutaraldehyde
metronidazole
add on therapy
adult
aged
article
bone graft
clinical article
clinical study
controlled study
dental scaling
disease classification
facial bone
fracture healing
human
medical resource shortage
osteolysis
periodontitis
root planing
suture removal
tablet
tissue regeneration
tooth plaque
wound dehiscence
xenograft
LA - English
PY - 2023
SN - ["0975-1580", "0972-124X"]
SP - 295-300
ST - Clinical and radiographic study of the use of cross-linked gelfoam matrix in
the treatment of dehiscence-like defects in Stage III periodontitis
T2 - J. Ind. Soc. Periodontol.
TI - Clinical and radiographic study of the use of cross-linked gelfoam matrix in
the treatment of dehiscence-like defects in Stage III periodontitis
VL - 27
ID - 13153
ER -
TY - JOUR
AB - Atorvastatin calcium (ATV) is a well-known anti-hyperlipidemic drug currently
being recognized for possessing an anti-inflammatory effect. Introducing it as a
novel remedy for periodontitis treatment necessitates developing a syringeable
modified delivery system capable of targeting inflammation within the periodontal
pockets. Thus, a 33 Box-Behnken design was used to generate eugenol enriched
PEGylated cubosomes. Based on the desirability function, the optimized formulation
(OEEPC) was selected exhibiting a solubilization efficiency (SE%) of 97.71 ± 0.49%,
particle size (PS) of 135.20 ± 1.11 nm, polydispersity index (PDI) of 0.09 ± 0.006,
zeta potential (ZP) of −28.30 ± 1.84 mV and showing a sustained drug release over
12 h. It displayed a cubic structure under the transmission electron microscope,
furthermore, it was stable upon storage for up to 30 days. Hence, it was loaded
into an optimum syringeable in-situ gel (ISG) which displayed the desired
periodontal gelation temperature (34 ± 0.70 °C) and an adequate gelation time (46 ±
2.82 sec), it also released approximately 75% of the drug within 72 h. Clinical
evaluation of the ISG showed a promising percentage reduction of about 58.33% in
probing depth, 90% in the bleeding index, 81.81% in the plaque index, and 70.21% in
gingival levels of transforming growth factor–β1. This proved that the formulated
syringeable intra-pocket delivery system of ATV is an efficient candidate for
diminishing inflammation in periodontitis.
AN - rayyan-563559760
AU - Elgendy, H. A.
AU - Makky, A. M. A.
AU - Elakkad, Y. E.
AU - Ismail, R. M.
AU - Younes, N. F.
DO - 10.1080/10717544.2022.2162159
IS - 1
KW - periodontal probe
transmission electron microscope
atorvastatin
eugenol
gel
interleukin 6
interleukin 8
adult
article
Box Behnken design
clinical assessment
comparative study
connective tissue
controlled study
disease severity
dispersity
drug release
emulsion
gelation
gingivitis
human
human experiment
hydrophobicity
in vitro study
molecular weight
normal human
particle size
PEGylation
periodontal pocket
periodontitis
plaque index
room temperature
solubilization
ultraviolet spectrophotometry
viscosity
zeta potential
LA - English
PY - 2023
SN - ["1521-0464", "1071-7544"]
ST - Syringeable atorvastatin loaded eugenol enriched PEGylated cubosomes in-situ
gel for the intra-pocket treatment of periodontitis: statistical optimization and
clinical assessment
T2 - Drug Deliv.
TI - Syringeable atorvastatin loaded eugenol enriched PEGylated cubosomes in-situ
gel for the intra-pocket treatment of periodontitis: statistical optimization and
clinical assessment
VL - 30
ID - 13134
ER -
TY - JOUR
AB - The present clinical trial aimed to assess the effectiveness of antimicrobial
photodynamic therapy versus Aloe vera gel as an adjunct to scaling and root planing
on periodontal and microbial outcomes in patients with periodontitis. Eligible
patients undergoing nonsurgical periodontal treatment were divided into 3 groups:
group 1: antimicrobial photodynamic therapy; group 2: Aloe vera gel application;
and group 3: scaling and root planing only. Clinical periodontal variables included
the assessment of plaque scores, bleeding on probing, probing depth, and clinical
attachment level gain. Plaque samples were collected to estimate microbial counts
of Tannerella forsythia (T. forsythia) and Porphyromonas gingivalis (P.
gingivalis). All measurements were recorded at baseline, 3 mo, and 6 mo.
Statistical analysis of the given data was performed using the chi-squared test and
ANOVA for clinical periodontal and microbiological data. Eighty-seven patients
completed the trial. Bleeding on probing showed a significant reduction in group 2
compared with the other groups (p < 0.001). Group 1 showed a statistically
significant reduction in probing depth and gain in clinical attachment level when
compared to group 2 and group 3 (p < 0.05). Group 1 showed a statistically
significant reduction in the counts of T. forsythia and P. gingivalis over a period
of 3 mo (p < 0.05). The reduction was seen for T. forsythia only following 6 mo (p
< 0.05). Group 2 showed a significant reduction for only T. forsythia at 3 mo (p <
0.05). Both antimicrobial photodynamic therapy and Aloe vera gel helped in reducing
periodontal inflammation. Aloe vera gel showed additional benefit in reducing
bleeding scores, while antimicrobial photodynamic therapy showed additional
enhanced activity against periodontal pathogens and periodontal attachment level
gain.
AN - rayyan-563560105
AU - Elsadek, M. F.
AU - Ahmed, B. M.
AU - Eskandrani, R. M.
AU - Fahmy, T. S.
DO - 10.1055/a-1159-0738
IS - 3
gel
adult
Aloe vera
article
controlled study
dental scaling
drug efficacy
female
gingiva bleeding
human
male
parallel design
periodontal pocket
periodontitis
photochemotherapy
priority journal
root planing
scoring system
tooth plaque
treatment outcome
LA - English
PY - 2020
SN - ["2509-6656", "2509-9264"]
SP - E100-E105
ST - Clinical and Microbiological Outcomes of Topical Aloe Vera Gel vs
Photochemotherapy as an Adjunct to Non-surgical Periodontal Treatment in
Periodontitis
T2 - Planta Medica Int. Open
TI - Clinical and Microbiological Outcomes of Topical Aloe Vera Gel vs
Photochemotherapy as an Adjunct to Non-surgical Periodontal Treatment in
Periodontitis
VL - 7
ID - 13479
ER -
TY - JOUR
AB - Aim: The aim of the present clinical trial was to assess the effectiveness of
antimicrobial photodynamic therapy (PDT) versus poly-L-glycolic acid nanoparticles
loaded methylene blue in aloe vera gel (PGA/MB/AV) on periodontal and microbial
outcomes in patients with Stage III Grade B periodontitis. Methods: Seven-five
patients undergoing scaling and root planing (SRP) were randomized equally into
three groups: Group-I: PGA/MB/AV + SRP, Group-II: PDT + SRP, and Group-III: SRP
alone. The assessed clinical periodontal parameters included plaque scores (PS),
bleeding on probing (BOP), pocket depth (PD), and clinical attachment levels (CAL).
Plaque samples were acquired from the patients to assess the levels of Tannerella
forsythia (Tf) and Porphyromonas gingivalis (Pg). Clinical and bacterial recording
were documented at the start of the study, 3 months, and 6 months after completion
of treatment. Results: A significant improvement was observed in both PS and BOP at
the 3 months (p<0.01) and 6 months (p<0.001) follow-up in all three groups. A
significant reduction in BOP scores was observed in Group II in comparison to the
other groups on the inter-group comparison. Group-I showed significant PD reduction
and CAL gain compared to Group II and III (p<0.01). Group-I displayed a significant
decrease in the Tf and Pg after 3 months (p<0.05). A decrease was observed after
six months of treatment for Tf only (p<0.05). Group I displayed a high decrease for
only Tf at three months (p<0.05). Conclusion: Methylene blue-loaded nanocarrier in
AV gel produced pronounced periodontal healing compared to aPDT alone in stage III
grade B periodontitis patients.
AN - rayyan-563559710
AU - Elsadek, M. F.
AU - Almoajel, A.
DO - 10.1016/j.pdpdt.2023.103586
KW - methylene blue
nanocarrier
nanoparticle
polyglycolic acid
adult
Aloe vera
antimicrobial photodynamic therapy
article
bleeding on probing
clinical article
clinical monitoring
controlled study
female
follow up
human
human tissue
male
nanotechnology
nonhuman
outcome assessment
periodontitis
periodontium
photochemotherapy
root planing
screening test
LA - English
PY - 2023
SN - ["1873-1597", "1572-1000"]
ST - Clinical and bacterial periodontal parameters with methylene blue-loaded
nanoparticles incorporated in a natural plant-based vehicle for the treatment of
Stage III Grade B periodontitis
TI - Clinical and bacterial periodontal parameters with methylene blue-loaded
nanoparticles incorporated in a natural plant-based vehicle for the treatment of
Stage III Grade B periodontitis
VL - 42
ID - 13084
ER -
TY - JOUR
AB - The incidence of S. sanguis, S. salivarius, S. mutans, total streptococci and
lactobacilli was examined in highly caries active 13-14-year-old schoolchildren
participating in a prophylactic program. After 1 year of trial, professional
toothcleaning once every second week markedly reduced the frequency of gingivitis
and the caries increment. Bimonthly topical applications of a 0.5% chlorhexidine
gel with or without subsequent rinsing with 2% MFP had no effect on plaque score
and gingivitis but tended to reduce the caries activity. No significant changes
were found in the groups with regard to the salivary number of total streptococci
and S. sanguis. A reduction of the population of S. salivarius, S. mutans and
lactobacilli was observed in the chlorhexidine group. In the group where
chlorhexidine was combined with MFP, only S. mutans was reduced.
AN - rayyan-563561189
AU - Emilson, C. G.
AU - Axelsson, P.
AU - Kallenberg, L.
DO - 10.1111/j.1600-0528.1982.tb01333.x
IS - 3
KW - chlorhexidine
fluorophosphate
pepsodent fluor
unclassified drug
adolescent
dental caries
gingivitis
mouth
mouth flora
prevention
school child
tooth
tooth plaque
LA - English
PY - 1982
SN - 0301-5661
SP - 111-116
ST - Effect of mechanical and chemical plaque control measures on oral microflora
in schoolchildren
T2 - COMMUNITY DENT. ORAL EPIDEMIOL.
TI - Effect of mechanical and chemical plaque control measures on oral microflora
in schoolchildren
VL - 10
ID - 14563
ER -
TY - JOUR
AB - This clinical study was conducted to quantify cultivable bacteria and
endotoxin in root canals with posttreatment apical periodontitis by correlating
their levels with clinical features and to evaluate the effect of chemomechanical
preparation (CMP) with 2 % chlorhexidine gel+17 % EDTA on bacterial and endotoxin
removal/elimination. Moreover, target strict Gram-negative anaerobic bacteria were
investigated by polymerase chain reaction (PCR). Fifteen teeth with post-treatment
apical periodontitis were sampled before (s1) and after (s2) CMP. Culture
techniques determined the number of colony-forming units (CFU). PCR (16S rDNA) and
limulus amebocyte lysate (LAL) assay were used for bacterial and endotoxin
detection, respectively. Prevotella nigrescens (4/15), Prevotella intermedia
(2/15), and Tannerella forsythia (2/15) were the most frequently detected species.
Endotoxin was recovered in 100 % of the samples. At s1, bacteria and endotoxin were
detected at a median value of 5.14 × 103 CFU/mL and 3.96 EU/mL, respectively.
Higher levels of endotoxin were related to a larger size of radiolucent area (>5
mm) (p<0.05). CMP was more effective in reducing bacteria (99.61 %) than endotoxin
(60.6 %) (both p<0.05). Our findings indicated that the levels of endotoxin found
in infected root canals were related to a larger size of radiolucent area in the
periapical region. Moreover, CMP was effective in reducing both bacterial and
endotoxin contents in post-treatment apical periodontitis. © Springer-Verlag 2012.
AN - rayyan-563560526
AU - Endo, M. S.
AU - Zaia, A. A.
DO - 10.1007/s10096-012-1598-6
IS - 10
KW - chlorhexidine
DNA 16S
edetic acid
endotoxin
article
bacterial count
bacterium culture
bacterium detection
colony forming unit
correlation analysis
disinfection
endodontics
human
Limulus lysate test
Prevotella
Prevotella tannerae
priority journal
tooth root canal
toxin analysis
Treponema
Treponema denticola
Treponema socranskii
LA - English
PY - 2012
SN - ["0934-9723", "1435-4373"]
SP - 2575-2583
ST - Quantification of cultivable bacteria and endotoxin in post-treatment apical
periodontitis before and after chemo-mechanical preparation
T2 - Eur. J. Clin. Microbiol. Infect. Dis.
TI - Quantification of cultivable bacteria and endotoxin in post-treatment apical
periodontitis before and after chemo-mechanical preparation
VL - 31
ID - 13900
ER -
TY - JOUR
AB - Objectives Titanium platelet-rich fibrin (T-PRF), a second-generation
autogenous blood concentrate with tough and thick fibrin meshwork activated by a
titanium tube, was used as a drug carrier for doxycycline (Doxy) by injection. The
objective of this study is to evaluate the loading capacity of T-PRF, release
kinetics of doxycycline-loaded T-PRF, and its antibacterial effects against S.
aureus and P. aeruginosa. Materials and methods The T-PRF and collagen were loaded
with Doxy as T-PRF/Doxy and Collagen/Doxy, and their release and antibacterial
activities against S. aureus and P. aeruginosa were investigated. Chemical
characterization and morphological analysis were performed. Results In comparison
with collagen, approximately sevenfold more Doxy, 281 mg/g, was loaded into T-PRF.
It was found that 25% of the loaded Doxy was released from T-PRF compared to only
12% from collagen within 72 h. The largest inhibition zone diameter (IZD) was
observed for T-PRF/Dox with 32 +/- 6 mm and 37 +/- 5 mm for P. aereginosa and S.
aureus, respectively. However, only 10 +/- 5 mm and 10 +/- 6 mm IZD were observed
for bare T-PRF, and no inhibition zone was observed for the Collagen/Doxy group. A
dense fibrin structure was visualized on SEM images of the T-PRF/Doxy group
compared to the T-PRF group. Conclusions T-PRF has higher Doxy loading capacity and
long-acting antibacterial effects compared to collagen. T-PRF was shown to have
potential autogenous long-term drug-carrying capability for doxycycline. Also, the
potential fibrinophilic properties of Doxy were observed to strengthen the
structure of T-PRF.
AN - rayyan-563562619
AU - Ercan, E.
AU - Suner, S. S.
AU - Silan, C.
AU - Yilmaz, S.
AU - Siddikoglu, D.
AU - Sahiner, N.
AU - Tunali, M.
DO - 10.1007/s00784-022-04510-0
IS - 8
PY - 2022
SN - ["1432-6981", "1436-3771"]
SP - 5429-5438
ST - Titanium platelet-rich fibrin (T-PRF) as high-capacity doxycycline delivery
system
TI - Titanium platelet-rich fibrin (T-PRF) as high-capacity doxycycline delivery
system
VL - 26
Y2 - 8
ID - 15993
ER -
TY - JOUR
AB - This study aimed to determine the intraradicular microbiota of previously
root canal-treated teeth with apical periodontitis and to investigate the
antibacterial effectiveness of different intracanal medicaments. Sixteen patients
with post-treatment apical periodontitis were allocated into two groups according
to the intracanal medicament used: calcium hydroxide (CH) and 2% chlorhexidine
gluconate gel (CHX) group. Total bacterial loads, as well as the amount of
Enterococcus faecalis (E. faecalis) were determined before (S1) and after (S2)
chemomechanical preparation and finally, after intracanal medication (S3) by means
of ddPCR. The unpaired t test was used to compare parametric. S3-total bacteria
copy number of the CH group was lower than the CHX group (p < 0.05). There was no
statistical difference between the CHX- and the CH groups in terms of E.faecalis
copy number (p > 0.05). But in terms of total bacteria, CH is better than CHX.
Consequently, CH can be used to optimise the antibacterial efficiency of
chemomechanical preparation in previously root canal-treated teeth with apical
periodontitis.
AN - rayyan-563559736
AU - Ersahan, S.
AU - Hepsenoglu, Y. E.
DO - 10.1111/aej.12613
IS - 1
calcium hydroxide
chlorhexidine
bacterium
dental pulp cavity
human
microbiology
LA - English
PY - 2023
SN - 1747-4477
SP - 75-86
ST - Microbial analysis of endodontic infections in teeth with post-treatment
apical periodontitis before and after medication
T2 - Aust Endod J
TI - Microbial analysis of endodontic infections in teeth with post-treatment
apical periodontitis before and after medication
VL - 49
ID - 13110
ER -
TY - JOUR
AN - rayyan-563561663
AU - Esfahanizadeh, N.
AU - Nourani, M. R.
AU - Bahador, A.
AU - Akhondi, N.
AU - Montazeri, M.
DO - 10.1515/bglass-2018-0009
IS - 1
PY - 2020
SP - 95-107
ST - The Anti-biofilm Activity of Nanometric Zinc doped Bioactive Glass against
Putative Periodontal Pathogens: An in vitro Study
T2 - Biomedical Glasses
TI - The Anti-biofilm Activity of Nanometric Zinc doped Bioactive Glass against
Putative Periodontal Pathogens: An in vitro Study
85078681599&doi=10.1515%2fbglass-2018-
0009&partnerID=40&md5=875e749ebff7c8270bcff31218795800
VL - 4
ID - 15037
ER -
TY - JOUR
AB - Background and Aim: Periodontitis is an infectious inflammatory disease
caused and aggravated by subgingival microbiota. The effectiveness of non-surgical
treatment is limited in areas inaccessible for mechanical instrumentation,
especially in deep pockets. Local delivery of antimicrobial agents into periodontal
pockets offers fewer side effects and improved compliance, in comparison with drugs
used systemically, however, they are facing challenges as administration into the
periodontal pocket and a high clearance rate of fluids from the pocket. This study
aims to develop and characterize a novel injectable hydrogel system for a delivery
of antiseptic/antibiotic drug (Chlorhexidine /Metronidazole) directly into the
periodontal pocket followed by insitu gelation. Methods: The injectable form of an
in-situ forming drug delivery system loaded with Chlorhexidine/Metronidazole was
prepared of natural polymers: gelatin and alginate known as biocompatible,
biodegradable, inexpensive, and widely available. Both were crosslinked by N-ethyl-
N-(3-dimethylaminopropyl) carbodiimide (EDC). The study focused on the effects of
the hydrogel formulation on the physical properties (gelation time, viscosity, and
swelling), mechanical properties (burst strength - sealing ability, tension, and
compression properties), in-vitro biological performance (cell viability test on
human fibroblasts), and the drug release profiles of both systems. Results: All
hydrogel systems demonstrated a combination of compatible gelation time (up to 10
s), good mechanical properties, injectability, and high biocompatibility. Drug
release studies indicated chlorhexidine release for 6 days and metronidazole
release for up to 24 h. The drug release mechanism of both systems was governed by
diffusion assisted by hydrogels' swelling and degradation. Conclusions: The
development of injectable antiseptic/antibiotic hydrogels with controllable
mechanical and physical properties is a very promising novel approach. With its
tunable abilities and mucoadhesive properties, the newly developed hydrogel may
serve as an excellent candidate for local treatment of periodontal disease.
AN - rayyan-563559848
AU - Eshkol-Yogev, I.
AU - Zussman, M.
AU - Zilberman, M.
DO - 10.1111/jcpe.13636
KW - alginic acid
antibiotic agent
antiinfective agent
chlorhexidine
gelatin
hydrogel
metronidazole
polymer
biocompatibility
cell viability
compression
conference abstract
controlled study
cross linking
diffusion
drug combination
drug formulation
drug release
fibroblast
gelation
human
in vitro study
local therapy
periodontal disease
periodontal pocket
swelling
tension
viscosity
LA - English
PY - 2022
SN - 1600-051X
SP - 172
ST - Novel injectable gelatine-alginate based hydrogels loaded with
antiseptic/antibiotic agents for local treatment of periodontal diseases
TI - Novel injectable gelatine-alginate based hydrogels loaded with
antiseptic/antibiotic agents for local treatment of periodontal diseases
VL - 49
ID - 13222
ER -
TY - JOUR
AB - The aim of the paper was to develop tetracycline-containing formulations for
the treatment of periodontitis by direct periodontal intrapocket administration.
Two different semi-solid formulations were prepared, based on
poly(oxyethylene)poly(oxypropylene) block copolymer (poloxamer) and monoglycerides,
respectively. Both formulations possess interesting properties as delivery systems.
They are easily administered by syringe equipped with needles appropriate for
intrapocket delivery, they are characterized by a sol-gel transition, becoming
semi-solid once in the periodontal pocket and, finally, they represent
biocompatible formulations eliminated from the body by normal routes. A theological
characterization of both formulations was performed in the presence or in the
absence of tetracycline, determining the sol-gel transition temperature (T(c)) by
'time cure tests' and the z coefficient by 'frequency sweep test'. In addition, the
in vitro tetracycline release from formulations was determined. Comparative in vivo
studies were conducted, in order (a) to compare the persistence of the gels on the
gum and (b) to evaluate the clinical performances of the gels. These latest studies
indicated that both poloxamer and monoglycerides gels, when applied subgingivally,
produce a significantly improved outcome in moderate to deep periodontal pockets.
AN - rayyan-563561056
AU - Esposito, E.
AU - Carotta, V.
AU - Scabbia, A.
AU - Trombelli, L.
AU - D'Antona, P.
AU - Menegatti, E.
AU - Nastruzzi, C.
DO - 10.1016/0378-5173(96)04649-2
IS - 1
KW - glycerol oleate
monoacylglycerol
poloxamer
tetracycline
adult
aged
article
clinical article
clinical trial
drug efficacy
drug formulation
drug release
female
gel
human
male
periodontitis
phase transition
priority journal
viscosity
lutrol fc 127
myverol
LA - English
PY - 1996
SN - 0378-5173
SP - 9-23
ST - Comparative analysis of tetracycline-containing dental gels: Poloxamer- and
monoglyceride-based formulations
T2 - INT. J. PHARM.
TI - Comparative analysis of tetracycline-containing dental gels: Poloxamer- and
monoglyceride-based formulations
VL - 142
ID - 14430
ER -
TY - JOUR
AB - OBJECTIVES: To identify the most effective interventions for treating peri-
implantitis around osseointegrated dental implants. DATA SOURCES: The Cochrane Oral
Health Group's Trials Register, CENTRAL, MEDLINE and EMBASE were searched and
several journals were handsearched with no language restriction up to January 2008.
REVIEW METHODS: Randomised controlled trials (RCTs) comparing interventions for
treating peri-implantitis were eligible. Screening of studies, quality assessment
and data extraction were conducted in duplicate. Missing information was requested.
Outcome measures were: implant failure; complications; changes in radiographic
marginal bone level, probing 'attachment' level (PAL), probing pocket depth (PPD),
and recession; aesthetics evaluated by patients and dentists; cost and treatment
time. RESULTS: Ten eligible trials were identified, and seven were included (148
patients). They tested: (1) local antibiotics vs ultrasonic debridement; (2)
adjunctive local antibiotics to debridement; (3) different techniques of
subgingival debridement; (4) laser vs manual debridement and chlorhexidine
irrigation/ gel; (5) systemic antibiotics plus resective surgery plus two local
antibiotics with and without implant surface smoothening; and (6) nanocrystalline
hydroxyapatite vs Bio-Oss and resorbable barriers. Follow up ranged from 3 months
to 2 years. After 4 months, adjunctive local antibiotics to manual debridement in
patients who lost at least 50% of peri-implant bone showed improved PAL and PPD
(0.6 mm). After 6 months, peri-implant infrabony defects > 3 mm treated with Bio-
Oss and barriers gained 0.5 mm more PAL and PPD than those treated with
hydroxyapatite. In four trials subgingival mechanical debridement seemed to achieve
results similar to more complex therapies. CONCLUSIONS: There is very little
reliable evidence suggesting which could be the most effective interventions for
peri-implantitis. Sample sizes were too small and follow up too short. This is not
to say that currently used interventions are ineffective. Larger well-designed RCTs
are needed.
AN - rayyan-563560705
AU - Esposito, M.
AU - Grusovin, M. G.
AU - Coulthard, P.
AU - Worthington, H. V.
IS - 2
bone prosthesis
bone regeneration
classification
debridement
dental surgery
follow up
human
literature
periodontitis
physiology
review
tooth implantation
treatment outcome
LA - English
PY - 2008
SN - 1756-2406
SP - 111-125
ST - The efficacy of interventions to treat peri-implantitis: a Cochrane
systematic review of randomised controlled clinical trials
T2 - Eur J Oral Implantol
TI - The efficacy of interventions to treat peri-implantitis: a Cochrane
systematic review of randomised controlled clinical trials
VL - 1
ID - 14079
ER -
TY - JOUR
AB - BACKGROUND: One of the key factors for the long-term success of oral implants
is the maintenance of healthy tissues around them. Bacterial plaque accumulation
induces inflammatory changes in the soft tissues surrounding oral implants and it
may lead to their progressive destruction (perimplantitis) and ultimately to
implant failure. Different treatment strategies for perimplantitis have been
suggested, however it is unclear which are the most effective. OBJECTIVES: To
identify the most effective interventions for treating perimplantitis around
osseointegrated dental implants. SEARCH STRATEGY: We searched the Cochrane Oral
Health Group's Trials Register, CENTRAL, MEDLINE and EMBASE. Handsearching included
several dental journals. We checked the bibliographies of the identified randomised
controlled trials (RCTs) and relevant review articles for studies outside the
handsearched journals. We wrote to authors of all identified RCTs, to more than 55
dental implant manufacturers and an Internet discussion group to find unpublished
or ongoing RCTs. No language restrictions were applied. The last electronic search
was conducted on 7th January 2010. SELECTION CRITERIA: All RCTs comparing agents or
interventions for treating perimplantitis around dental implants. DATA COLLECTION
AND ANALYSIS: Screening of eligible studies, assessment of the methodological
quality of the trials and data extraction were conducted in duplicate and
independently by two review authors. We contacted the authors for missing
information. Results were expressed as random-effects models using mean differences
for continuous outcomes and risk ratios for dichotomous outcomes with 95%
confidence intervals (CI). Heterogeneity was to be investigated including both
clinical and methodological factors. MAIN RESULTS: Twelve eligible trials were
identified, but five were excluded. The following procedures were tested: (1) use
of local antibiotics versus ultrasonic debridement; (2) benefits of adjunctive
local antibiotics to debridement; (3) different techniques of subgingival
debridement; (4) laser versus manual debridement and chlorhexidine irrigation/gel;
(5) systemic antibiotics plus resective surgery plus two different local
antibiotics with and without implant surface smoothening; and (6) nanocrystalline
hydroxyapatite versus Bio-Oss and resorbable barriers. Follow-up ranged from 3
months to 4 years. The only statistically significant differences were observed in
two trials judged to be at high risk of bias. After 4 months, adjunctive local
antibiotics to manual debridement in patients who lost at least 50% of the bone
around implants showed improved mean probing attachment levels (PAL) of 0.61 mm and
reduced probing pockets depths (PPD) of 0.59 mm. After 4 years, patients with
perimplant infrabony defects > 3 mm treated with Bio-Oss and resorbable barriers
gained 1.4 mm more PAL and PPD than patients treated with a nanocrystalline
hydroxyapatite. AUTHORS' CONCLUSIONS: There is very little reliable evidence
suggesting which could be the most effective interventions for treating
perimplantitis. This is not to say that currently used interventions are not
effective. The use of local antibiotics in addition to manual subgingival
debridement was associated with a 0.6 mm additional improvement for PAL and PPD
over a 4-month period in patients affected by severe forms of perimplantitis. After
4 years, improved PAL and PPD of about 1.4 mm were obtained when using Bio-Oss with
resorbable barriers compared to a nanocrystalline hydroxyapatite in perimplant
infrabony defects. In four trials, the control therapy which basically consisted of
a simple subgingival mechanical debridement seemed to be sufficient to achieve
similar results to the more complex and expensive therapies. Follow-up longer than
1 year suggested recurrence of perimplantitis up to 100% of the treated cases for
some of the tested interventions. Sample sizes were very small and follow-up too
short, therefore these findings have to be considered with great caution. Larger
well-designed RCTs with foll w-up longer than 1 year are needed.
AN - rayyan-563560631
AU - Esposito, M.
AU - Tzanetea, E.
AU - Piattelli, A.
debridement
dental surgery
gingivitis
human
meta analysis
methodology
periodontal disease
periodontitis
review
stomatitis
tooth implantation
LA - English
PY - 2010
SN - 1469-493X
SP - CD004970
ST - Interventions for replacing missing teeth: treatment of perimplantitis
T2 - Cochrane Database Syst Rev
TI - Interventions for replacing missing teeth: treatment of perimplantitis
VL - 6
ID - 14005
ER -
TY - JOUR
AB - Purpose: Binary polymeric systems containing poloxamer 407 (P407) and
Carbopol 934P (C934P) were designed to deliver propolis extract (PE) or sildenafil
citrate for the endodontic treatment (pulp protection). Methods: Gelation
temperature, rheology (flow), bioadhesion, and in vitro drug release of
formulations were determined. Results: Formulations showed thermoresponsive
behavior, existing as a liquid at room temperature and gel at 34-37 degrees C. In
addition, they exhibited pseudoplastic flow and low degrees of thixotropy or
rheopexy. The greatest bioadhesion was noted in the formulation containing 20% P407
(w/w) and 0.10% C934P (w/w). PE release from formulation containing 15% P407 (w/w)
and 0.25% C934P (w/w) was controlled by the phenomenon of relaxation of polymer
chains. Moreover, sildenafil release from formulation containing 20% P407 (w/w) and
0.10% C934P (w/w) was controlled by Fickian diffusion. Conclusion: The data
obtained on these formulations indicate a potentially useful role in the endodontic
treatment (pulp protection) and suggest they are worthy of clinical evaluation.
AN - rayyan-563562632
AU - Fabri, F. V.
AU - Cupertino, R. R.
AU - Hidalgo, M. M.
AU - Maria, R.
AU - de Oliveira, M. W.
AU - Bruschi, M. L.
DO - 10.3109/03639045.2011.584387
IS - 12
PY - 2011
SN - ["0363-9045", "1520-5762"]
SP - 1446-1454
ST - Preparation and characterization of bioadhesive systems containing propolis
or sildenafil for dental pulp protection
T2 - DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
TI - Preparation and characterization of bioadhesive systems containing propolis
or sildenafil for dental pulp protection
VL - 37
Y2 - 12
ID - 16006
ER -
TY - JOUR
AB - Frequently, sinus augmentation is required when replacing failing or missing
molars in the maxilla due to loss of alveolar bone related to periodontal disease,
pneumatization of the sinus or a combination of the two factors. Various materials
have been advocated and utilized; these fall into the categories of allograft,
xenograft and synthetic materials. This article shall discuss a study of 10 cases
with a 2-year follow-up utilizing a novel synthetic graft material used for sinus
augmentation either simultaneously with implant placement or in preparation for
sinus augmentation and implant placement in the posterior maxilla. The results of
the 10 cases in the study found consistent results over the 2-year study period
with maintenance of the alveolar height at the maxillary sinus. A lack of
complications or failures in the study group demonstrates the technique has useful
applications in increasing ridge height to permit implant placement inferior to the
sinus floor.
AN - rayyan-563559725
AU - Fairbairn, P.
AU - Kilner, S.
AU - O’Hooley, D.
AU - Fish, A.
AU - Kurtzman, G. M.
DO - 10.3390/jcm12072485
IS - 7
KW - bone screw
Densah
dental burr
dental drill
dental syringe
endosseous implant
EthOss
Paltop Advanced
suture
synthetic bone graft
X ray film
amoxicillin
blue m
calcium phosphate
calcium sulfate
gel
local anesthetic agent
adult
aged
alveolar bone loss
article
bone regeneration
case report
clinical article
clinical outcome
delayed immediate socket grafting
female
follow up
healing
home care
human
image analysis
implantation
male
maxilla
maxillary sinus
middle aged
osteotomy
outcome assessment
patient safety
reconstructive surgery
soft tissue
tooth radiography
Anyridge
LA - English
PY - 2023
SN - 2077-0383
ST - Sinus Augmentation for Implant Placement Utilizing a Novel Synthetic Graft
Material with Delayed Immediate Socket Grafting: A 2-Year Case Study
T2 - J. Clin. Med.
TI - Sinus Augmentation for Implant Placement Utilizing a Novel Synthetic Graft
Material with Delayed Immediate Socket Grafting: A 2-Year Case Study
VL - 12
ID - 13099
ER -
TY - JOUR
AB - Chitosan is a natural biopolymer derived from deacetylation of chitin and it
has been investigated with interdisciplinary approaches for multitude applications.
Chitosan biomaterials possess unique properties such as biocompatibility,
biodegradability, non-toxicity, muco-adhesion and a wide range of antibacterial and
antifungal activity. Additionally, chitosan is the only cationic polysaccharide in
nature and can be chemically modified to derivatives, based on the aim of function
and application. The distinctive properties of chitosan and its derivatives have
aroused interest in pharmaceutical industries and biomedical fields worldwide. This
review discusses the crucial role of chitosan in production of bio-dental materials
and accentuates its current profitable utilizations in oral drug delivery system,
bone tissue engineering for treatment of periodontitis and dentin-pulp
regeneration. Chemical modifications and incorporation of diverse bioactive
molecules in order to improve the mechanical and biological characteristics of
chitosan have also been discussed. (C) 2020 Elsevier B.V. All rights reserved.
AN - rayyan-563562508
AU - Fakhri, E.
AU - Eslami, H.
AU - Maroufi, P.
AU - Pakdel, F.
AU - Taghizadeh, S.
AU - Ganbarov, K.
AU - Yousefi, M.
AU - Tanomand, A.
AU - Yousefi, B.
AU - Mahmoudi, S.
AU - Kafil, H. S.
DO - 10.1016/j.ijbiomac.2020.06.211
PY - 2020
SN - ["0141-8130", "1879-0003"]
SP - 956-974
ST - Chitosan biomaterials application in dentistry
T2 - INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
TI - Chitosan biomaterials application in dentistry
VL - 162
Y2 - 11 y3 - 1
ID - 15882
ER -
TY - JOUR
AB - The main purpose of this study was to investigate the substantivity of Ag-Ca-
Si mesoporous nanoparticles (Ag-MCSNs) on dentin and its residual antibacterial
effects against Enterococcus faecalis. Ag-MCSNs were fabricated and characterized,
ion release profile and pH were tested, and the ability to inhibit planktonic E.
faecalis as well as the cytotoxicity was evaluated. Dentin slices were medicated
with Ca(OH)(2) paste, 2 % chlorhexidine gel and Ag-MCSNs paste for 7 days and then
irrigated. Dentin slices were then immersed in E. faecalis suspension for 6 days
and then transferred to fresh brain heart infusion solution. The optical density
value within 10 h after immersing and transferring were measured and compared among
groups. Results indicated that Ag-MCSNs showed high pH, sustained Ag+-Ca2+-SiO32-
ion release, and high substantivity on dentin. The Ag-MCSNs exhibited strong
antibacterial effects against planktonic E. faecalis and much better residual
inhibition effects against E. faecalis growth on dentin than Ca(OH)(2) paste
(P<0.05). The Ag-MCSNs showed excellent antibacterial ability against E. faecalis
and high substantivity on dentin, which might be developed to a new effective
intra-canal medicament for human teeth.
AN - rayyan-563562595
AU - Fan, W.
AU - Wu, Y. J.
AU - Ma, T. J.
AU - Li, Y. Y.
AU - Fan, B.
DO - 10.1007/s10856-015-5633-x
IS - 1
PY - 2016
SN - ["0957-4530", "1573-4838"]
ST - Substantivity of Ag-Ca-Si mesoporous nanoparticles on dentin and its ability
to inhibit Enterococcus faecalis
TI - Substantivity of Ag-Ca-Si mesoporous nanoparticles on dentin and its ability
to inhibit Enterococcus faecalis
VL - 27
Y2 - 1
ID - 15969
ER -
TY - JOUR
AB - Aloe vera is a medicinal plant with anti-inflammatory, antimicrobial,
antidiabetic and immune-boosting properties. In the present study we investigated
the inhibitory activities of Aloe vera gel on some cariogenic (Streptococcus
mutans), periodontopathic (Aggregatibacter actinomycetemcomitans, Porphyromonas
gingivalis) and an opportunistic periodontopathogen (Bacteroides fragilis) isolated
from patients with dental caries and periodontal diseases. Twenty isolates of each
of these bacteria were investigated for their sensitivity to Aloe vera gel using
the disk diffusion and microdilution methods. S. mutans was the species most
sensitive to Aloe vera gel with a MIC of 12.5 μg/ml, while A.
actinomycetemcomitans, P. gingivalis, and B. fragilis were less sensitive, with a
MIC of 25-50 μg/ml (P < 0.01). Based on our present findings it is concluded that
Aloe vera gel at optimum concentration could be used as an antiseptic for
prevention of dental caries and periodontal diseases.
AN - rayyan-563560555
AU - Fani, M.
AU - Kohanteb, J.
DO - 10.2334/josnusd.54.15
IS - 1
KW - alloin
drug derivative
emodin
plant extract
Aloe
article
bacterial count
Bacteroides
chemistry
dental caries
drug effect
gel
human
microbiology
periodontal disease
plant leaf
LA - English
PY - 2012
SN - 1880-4926
SP - 15-21
ST - Inhibitory activity of Aloe vera gel on some clinically isolated cariogenic
and periodontopathic bacteria
T2 - J Oral Sci
TI - Inhibitory activity of Aloe vera gel on some clinically isolated cariogenic
and periodontopathic bacteria
VL - 54
ID - 13929
ER -
TY - JOUR
AB - Due to their osteoconductive and osteoinductive abilities, bioglasses (BGs)
have attracted attention in tissue engineering, especially for mineralized tissue.
The aim of this study is to review the current state of the art on the effects of
BGs produced by sol-gel on cells for dental and periodontal regeneration. The study
also discusses associated antibacterial properties. The research was performed by
considering the Preferred Reporting Items for Systematic Reviews and the Meta-
Analyses (PRISMA) statement. The research ranged 5 years' window time (from
January, 01, 2012, to August, 31, 2017) and the relevant studies were identified
based on the inclusion/exclusion criteria. A total of 45 articles were selected
from 244 initial returns, plus seven further articles coming from other sources
were selected for the same purpose. From this systematic study, it is revealed that
only 13 of the 52 articles have proved both the ability of BGs to differentiate
dental cells at genetic level and their ability of triggering cell-mediated
mineralization, but only six of them showed, along with cells, the antibacterial
properties of the glasses. This review shows that sol-gel BGs are not toxic, can
sustain cell proliferation and differentiation at a genetic level, and can keep the
bacterial population under control. Moreover, a standard methodology and an ideal
material are suggested. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B:
Appl Biomater 107B: 1210-1227, 2019.
AN - rayyan-563560810
AU - Farano, V.
AU - Maurin, J. C.
AU - Attik, N.
AU - Jackson, P.
AU - Grosgogeat, B.
AU - Gritsch, K.
DO - 10.1002/jbm.b.34214
IS - 4
KW - *Bone Regeneration
Calcification, Physiologic/*drug effects
*Ceramics/chemistry/therapeutic use
Humans
Periodontium/*physiology
Phase Transition
Regeneration/*drug effects
LA - eng
N1 - Université Lyon, Université Claude Bernard Lyon 1, CNRS, Laboratoire des
Multimatériaux et Interfaces, Villeurbanne, France.; Faculté d'Odontologie,
Université Claude Bernard Lyon 1, Lyon, France.; Université Lyon, Université Claude
Bernard Lyon 1, CNRS, Laboratoire des Multimatériaux et Interfaces, Villeurbanne,
France.; Faculté d'Odontologie, Université Claude Bernard Lyon 1, Lyon, France.;
Service d'Odontologie, Hospices Civils de Lyon, Lyon, France.; Université Lyon,
Université Claude Bernard Lyon 1, CNRS, Laboratoire des Multimatériaux et
Interfaces, Villeurbanne, France.; Faculté d'Odontologie, Université Claude Bernard
Lyon 1, Lyon, France.; Lucideon Limited, Queens Road, Penkhull, Stoke-on-Trent,
Staffordshire, ST4 7LQ, UK.; Université Lyon, Université Claude Bernard Lyon 1,
CNRS, Laboratoire des Multimatériaux et Interfaces, Villeurbanne, France.; Faculté
d'Odontologie, Université Claude Bernard Lyon 1, Lyon, France.; Service
d'Odontologie, Hospices Civils de Lyon, Lyon, France.; Université Lyon, Université
Claude Bernard Lyon 1, CNRS, Laboratoire des Multimatériaux et Interfaces,
Villeurbanne, France.; Faculté d'Odontologie, Université Claude Bernard Lyon 1,
Lyon, France.; Service d'Odontologie, Hospices Civils de Lyon, Lyon, France.
PY - 2019
SP - 1210-1227
ST - Sol-gel bioglasses in dental and periodontal regeneration: A systematic
review
TI - Sol-gel bioglasses in dental and periodontal regeneration: A systematic
review
VL - 107
Y2 - 5
ID - 14184
ER -
TY - JOUR
AB - Due to their osteoconductive and osteoinductive abilities, bioglasses (BGs)
have attracted attention in tissue engineering, especially for mineralized tissue.
The aim of this study is to review the current state of the art on the effects of
BGs produced by sol–gel on cells for dental and periodontal regeneration. The study
also discusses associated antibacterial properties. The research was performed by
considering the Preferred Reporting Items for Systematic Reviews and the Meta-
Analyses (PRISMA) statement. The research ranged 5 years' window time (from
January, 01, 2012, to August, 31, 2017) and the relevant studies were identified
based on the inclusion/exclusion criteria. A total of 45 articles were selected
from 244 initial returns, plus seven further articles coming from other sources
were selected for the same purpose. From this systematic study, it is revealed that
only 13 of the 52 articles have proved both the ability of BGs to differentiate
dental cells at genetic level and their ability of triggering cell-mediated
mineralization, but only six of them showed, along with cells, the antibacterial
properties of the glasses. This review shows that sol–gel BGs are not toxic, can
sustain cell proliferation and differentiation at a genetic level, and can keep the
bacterial population under control. Moreover, a standard methodology and an ideal
material are suggested. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B:
Appl Biomater 107B: 1210–1227, 2019.
AN - rayyan-563560192
AU - Farano, V.
AU - Maurin, J. C.
AU - Attik, N.
AU - Jackson, P.
AU - Grosgogeat, B.
AU - Gritsch, K.
DO - 10.1002/jbm.b.34214
IS - 4
KW - composite material
chlorhexidine
osteocalcin
osteopontin
polycaprolactone
bone mineralization
cell proliferation
cytotoxicity
dental restoration
Escherichia coli
gene expression
human
nonhuman
particle size
review
surface area
surface property
systematic review
tissue regeneration
LA - English
PY - 2019
SN - ["1552-4981", "1552-4973"]
SP - 1210-1227
ST - Sol–gel bioglasses in dental and periodontal regeneration: A systematic
review
TI - Sol–gel bioglasses in dental and periodontal regeneration: A systematic
review
VL - 107
ID - 13566
ER -
TY - JOUR
AB - Objective > The present study was aimed to assess the effectiveness of
antimicrobial gels along with conventional tooth brushing to improve gingival
health in patients undergoing fixed orthodontic treatment. Materials and methods >
All randomized and non-randomized clinical trials done on human subjects were
explored in major health science databases (PubMed, CINAHL Plus, EBSCO Dent & Oral
Sciences and Cochrane). An additional manual search was done on Google Scholar and
on www.clinicaltrials.gov to identify any grey literature and unpublished data.
Date of publication was not restricted during the data search. The assessment of
risk of bias was done using the Cochrane Collaboration's Risk of Bias assessment
tool. The meta-analysis was done using Review Manager Version 5.3.5 to analyse
probing depth to be in two and four-week follow-up. This systematic review is
reported according to the PRISMA statement and registered at PROSPERO
(CR042018084530). Results > The electronic database search yielded 3733 records;
hand search identified 14 articles meeting the selection criteria which were
included in the qualitative data synthesis. Significant improvement in gingivitis
has been reported using antioxidant-essential oil gel, cervitec gel (0.2%
chlorhexidine), 2% chlorhexidine gel, amine fluoride gel, and 0.4% stannous
fluoride gel with > 98% availability of Sn+2 ions. Three articles with probing
depth as comparable parameter were used for quantitative analysis. At the two and
four-week follow-up, overall insignificant differences were observed in the
antimicrobial gel group compared to the control group with regard to probing depth.
Conclusions > The use of antioxidant-essential oil gel, amine fluoride gel, 0.4%
stannous fluoride gel (98% availability of Sn+2) and 2% chlorhexidine gel resulted
in significant improvement in gingivitis. However, probing depth in follow-up
visits showed no significant difference between antimicrobial gel and control
group.
AN - rayyan-563562277
AU - Fatima, F.
AU - Mahmood, H. T.
AU - Fida, M.
AU - Sukhia, R. H.
DO - 10.1016/j.ortho.2019.10.002
IS - 1
PY - 2020
SN - ["1761-7227", "1879-680X"]
SP - 10-21
ST - Effectiveness of antimicrobial gels on gingivitis during fixed orthodontic
treatment: A systematic review and meta-analysis
T2 - INTERNATIONAL ORTHODONTICS
TI - Effectiveness of antimicrobial gels on gingivitis during fixed orthodontic
VL - 18
Y2 - 3
ID - 15651
ER -
TY - JOUR
AB - OBJECTIVE: The present study was aimed to assess the effectiveness of
antimicrobial gels along with conventional tooth brushing to improve gingival
health in patients undergoing fixed orthodontic treatment. MATERIALS AND METHODS:
All randomized and non-randomized clinical trials done on human subjects were
explored in major health science databases (PubMed, CINAHL Plus, EBSCO Dent & Oral
Sciences and Cochrane). An additional manual search was done on Google Scholar and
on www.clinicaltrials.gov to identify any grey literature and unpublished data.
Date of publication was not restricted during the data search. The assessment of
risk of bias was done using the Cochrane Collaboration's Risk of Bias assessment
tool. The meta-analysis was done using Review Manager Version 5.3.5 to analyse
probing depth to be in two and four-week follow-up. This systematic review is
reported according to the PRISMA statement and registered at PROSPERO
(CRD42018084530). RESULTS: The electronic database search yielded 3733 records;
hand search identified 14 articles meeting the selection criteria which were
included in the qualitative data synthesis. Significant improvement in gingivitis
has been reported using antioxidant-essential oil gel, cervitec gel (0.2%
chlorhexidine), 2% chlorhexidine gel, amine fluoride gel, and 0.4% stannous
fluoride gel with>98% availability of Sn+2 ions. Three articles with probing depth
as comparable parameter were used for quantitative analysis. At the two and four-
week follow-up, overall insignificant differences were observed in the
antimicrobial gel group compared to the control group with regard to probing depth.
CONCLUSIONS: The use of antioxidant-essential oil gel, amine fluoride gel, 0.4%
stannous fluoride gel (98% availability of Sn+2) and 2% chlorhexidine gel resulted
in significant improvement in gingivitis. However, probing depth in follow-up
visits showed no significant difference between antimicrobial gel and control
group.
AN - rayyan-563560135
AU - Fatima, F.
AU - Taha Mahmood, H.
AU - Fida, M.
AU - Hoshang Sukhia, R.
DO - 10.1016/j.ortho.2019.10.002
IS - 1
KW - amine
amine fluoride gel
antiinfective agent
chlorhexidine
essential oil
thymol
tin fluoride
adverse event
drug combination
gel
gingivitis
human
meta analysis
orthodontics
tooth brushing
LA - English
PY - 2020
SN - 1879-680X
SP - 10-21
ST - Effectiveness of antimicrobial gels on gingivitis during fixed orthodontic
T2 - Int Orthod
TI - Effectiveness of antimicrobial gels on gingivitis during fixed orthodontic
VL - 18
ID - 13509
ER -
TY - JOUR
AB - Objective: To evaluate the effect of home-use bleaching agent containing 16%
Carbamide Peroxide (CP) and in-office bleaching agent with 38% Hydrogen Peroxide
(HP) on surface micro-morphology of enamel. Study Design: An experimental study.
Place and Duration of Study: The discs were prepared at Material Engineering
Department of NED University of Engineering and Technology, Karachi, and surface
morphology was analyzed at Centralized Science Laboratory of Karachi University,
Pakistan. Duration of study was one year from January to December 2012.
Methodology: Forty five sound human third molar crowns, extracted for periodontal
reason, were included in the study. Longitudinal sections were made using diamond
disks (0.2 mm) under water lubrication to obtain enamel slabs measuring (3 mm x 3
mm). The slabs were embedded in polystyrene resin by using 2.0 cm diameter PVC
molds, leaving the outer enamel surface uncovered by the resin. Ninety dental
enamel slabs were prepared. The slabs were then randomly divided into 3 groups.
Each group contained thirty specimens (n=30). Group 1 was kept in artificial saliva
at 37°C in incubator (Memart, Germany) during whole experiment. Group 2 was treated
with power whitening gel (White Smile 2011, Germany). Group 3 was treated with
tooth whitening pen (White Smile 2011, Germany). The most central region or the
region that was most representative of the entire surface area was used. The SEM
(Jeol-Japan-JSM6380A, JAPAN) micrographs were examined to determine the type of
surface presented. The enamel changes were classified as no or mild alteration,
moderate alteration and severe altered surface. Results: Regarding micro-
morphology, the enamel surface of control groups showed smooth surface in general
with some scattered clear scratches due to the polishing procedure. The specimens
bleached in group 2 and group 3, represented areas of mild erosion. Conclusion:
Bleaching with 38% Hydrogen Peroxide (HP) and 16% Carbamide Peroxide (CP) resulted
in mild changes in surface micro-morphology of enamel.
AN - rayyan-563560360
AU - Fatima, N.
IS - 1
diamond
hydrogen peroxide
peroxide
polystyrene
polyvinylchloride
resin
saliva substitute
urea
water
article
comparative study
controlled study
enamel
engineering and technology
human
human tissue
in vitro study
laboratory
lubrication
micromorphology
molar tooth
Pakistan
surface area
surface property
tooth crown
tooth extraction
LA - English
PY - 2016
SN - ["1681-7168", "1022-386X"]
SP - 9-12
ST - In-vitro comparative study of in-office and home bleaching agents on surface
micro-morphology of enamel
T2 - J. Coll. Phys. Surg. Pak.
TI - In-vitro comparative study of in-office and home bleaching agents on surface
micro-morphology of enamel
VL - 26
ID - 13734
ER -
TY - JOUR
AB - Objective: The tobacco leaves are a rich source of many biologically active
substances. Flavonoids are one of the bioactive substances contained in tobacco
leaves with a wide range of pharmacological properties. This study has been aimed
to formulate the antibacterial periodontal gel containing the flavonoids fraction
of Kasturi tobacco (Nicotiana tabacum) leaves. Methods: Fraction flavonoids
obtained from methanolic extracts of tobacco leaves, which have been purified from
nicotine. Different concentrations of flavonoids fraction (0, 25, 0,5, 1, 2, and 4
mg/ml) were prepared with Carbopol-974P. The strength of flavonoid gel adhesion in
ex vivo mucosa was tested by the falling liquid film method. Evaluation of in vitro
antibacterial agent was followed by the disk diffusion method. Results: The
flavonoid gels have better adhesion parameters (time, strength, and distance) than
gel bases. The antimicrobial by the zone of inhibition studies proved that
flavonoids periodontal gels with concentrations of 4 mg/ml are highly active
against Porphyromonas gingivalis with the zone of inhibition >10 mm which was
higher than quercetin gel formulations (control groups). Conclusion: Gel
formulation containing the flavonoids fraction of Kasturi tobacco (N. tabacum)
leaves could be a good candidate for periodontal gel with good mucoadhesive gel and
antibacterial agent.
AN - rayyan-563560216
AU - Febi, Q. N.
AU - Rosidah, M.
AU - Azis, D. A.
AU - Puspitasari, E.
AU - Nugraha, A. S.
AU - Kusumawardani, B.
DO - 10.22159/ajpcr.2019.v12i11.34967
IS - 11
KW - article
controlled study
disk diffusion
drug formulation
ex vivo study
human tissue
mucosa
Nicotiana tabacum
nonhuman
periodontitis
periodontium
plant leaf
zone of inhibition
carbopol 974p
nicotine
quercetin
LA - English
PY - 2019
SN - ["2455-3891", "0974-2441"]
SP - 109-111
ST - Kasturi tobacco leaf flavonoids as bioactive compounds in periodontal
antibacterial mucoadhesive gel
TI - Kasturi tobacco leaf flavonoids as bioactive compounds in periodontal
antibacterial mucoadhesive gel
VL - 12
ID - 13590
ER -
TY - JOUR
AN - rayyan-563561680
AU - Fedotova, V. V.
AU - Konovalov, D. A.
DO - 10.5530/ijper.53.4s.144
IS - 4
PY - 2019
SP - S500-S509
ST - Propolis research in Russia
T2 - Indian Journal of Pharmaceutical Education and Research
TI - Propolis research in Russia
85075190729&doi=10.5530%2fijper.53.4s.144&partnerID=40&md5=6f4afc58c97553307e82a917
c99bcd3f
VL - 53
ID - 15054
ER -
TY - JOUR
AB - The aim of our study was to develop water-free lyotropic liquid crystalline
preconcentrates, which consist of oils and surfactants with good physiological
tolerance and spontaneously form lyotropic liquid crystalline phase in aqueous
environment. In this way these preconcentrates having low viscosity can be injected
into the periodontal pocket, where they are transformed into highly viscous liquid
crystalline phase, so that the preparation is prevented from flowing out of the
pocket due to its great viscosity, while drug release is controlled by the liquid
crystalline texture. In order to follow the structure alteration upon water
absorption polarization microscopical and theological examinations were performed.
The water absorption mechanism of the samples was examined by the Enslin-method.
Metronidazole-benzoate was used as active agent the release of which was
characterized via in vitro investigations performed by means of modified Kirby-
Bauer disk diffusion method. On the grounds of the results it can be stated that
the 4:1 mixture of the investigated surfactants (Cremophor EL, Cremophor RH40) and
oil (Miglyol 810) formed lyotopic liquid crystalline phases upon water addition.
Polarization microscopic examinations showed that samples with 10-40% water content
possessed anisotropic properties. On the basis of water absorption, theological and
drug release studies it can be concluded that the amount of absorbed water and
stiffness of lyotropic structure influenced by the chemical entity of the
surfactant exerted major effect on the drug release. (C) 2008 Elsevier B.V. All
rights reserved.
AN - rayyan-563562458
AU - Feher, A.
AU - Urban, E.
AU - Eros, I.
AU - Szabo-Revesz, P.
AU - Csanyi, E.
DO - 10.1016/j.ijpharm.2008.02.025
IS - 1
PY - 2008
SN - 0378-5173
SP - 23-26
ST - Lyotropic liquid crystal preconcentrates for the treatment of periodontal
disease
T2 - INTERNATIONAL JOURNAL OF PHARMACEUTICS
TI - Lyotropic liquid crystal preconcentrates for the treatment of periodontal
disease
VL - 358
Y2 - 6 y3 - 24
ID - 15832
ER -
TY - JOUR
AB - Background: The treatment of periodontal disease focuses on eradication or
suppression of the pathogenic microbiota within the periodontal pocket. There are
some mechanical and chemical ways, and recently antimicrobial photodynamic therapy
to eliminate the bacteria.The aim of this in vitro study was to compare the effects
of 2% chlorhexidine gel, 2% metronidazole in Orabase, antimicrobial photodynamic
therapy with Emundo solution and Emundo solution on P. gingivalis. Methods: The
antibacterial activities of 2% CHX gel, 2% Metronidazole in Orabase, Emundo + Laser
(an infra-red laser diode of 810 nm, 300 mW, continuous mode radiation, 30 s and
energy density of 11.5 J/cm2), and Emundo against P. gingivalis was tested in vitro
using two different methods; (1) Counting CFU/mL and (2) agar diffusion test (ADT).
Data of CFU/mL were analyzed using one way ANOVA and Post hoc Tukey test (p <
0.05). Data obtained from ADT test were analyzed using Kruskal-Wallis. Results: The
percentage of colony-forming units reduction was (99.75, 99.98) in Metronidazole,
(99.66, 99.85) in CHX, and (96.68, 96.68) in Laser + Emundo (96.68, 96.68) groups
after 24 and 48 h, respectively. The amount of bacterial reduction in terms of
log10 CFU/mL was decreased in the Metronidazole, CHX, Laser + Emundo and, Emundo
groups, respectively after 48 h (p < 0.05). The inhibition zone radius was
decreased in CHX, Metronidazole and, Laser + Emundo, respectively (p < 0.05).
Conclusions: It can be concluded that within the limitations of this in-vitro
study, although photodynamic therapy with Emundo reduced the amount of P.
gingivalis significantly, the use of metronidazole 2% in Orabase performed better
in terms of reducing the amount of the bacteria. Also, the antibacterial effect of
2% CHX gel on P. gingivalis was significantly more than photodynamic therapy with
Emundo.
AN - rayyan-563560334
AU - Fekrazad, R.
AU - Karamifar, K.
AU - Bahador, A.
DO - 10.1016/j.pdpdt.2016.04.003
KW - chlorhexidine
metronidazole
orabase
agar diffusion
article
bacterial viability
CFU counting
controlled study
diode laser
drug effect
gel
in vitro study
zone of inhibition
nonhuman
priority journal
chlorhexidina s
LA - English
PY - 2016
SN - ["1873-1597", "1572-1000"]
SP - 28-33
ST - Comparison of antibacterial effect of photodynamic therapy using indocyanine
green (Emundo) with 2% metronidazole and 2% chlorhexidine gel on Porphyromonas
gingivalis (an in-vitro study)
TI - Comparison of antibacterial effect of photodynamic therapy using indocyanine
VL - 15
ID - 13708
ER -
TY - COMP
AB - BACKGROUND: The treatment of periodontal disease focuses on eradication or
suppression of the pathogenic microbiota within the periodontal pocket. There are
some mechanical and chemical ways, and recently antimicrobial photodynamic therapy
to eliminate the bacteria. The aim of this in vitro study was to compare the
effects of 2% chlorhexidine gel, 2% metronidazole in Orabase, antimicrobial
photodynamic therapy with Emundo solution and Emundo solution on P. gingivalis.
METHODS: The antibacterial activities of 2% CHX gel, 2% Metronidazole in Orabase,
Emundo+Laser (an infra-red laser diode of 810nm, 300mW, continuous mode radiation,
30s and energy density of 11.5J/cm2), and Emundo against P. gingivalis was tested
in vitro using two different methods; (1) Counting CFU/mL and (2) agar diffusion
test (ADT). Data of CFU/mL were analyzed using one way ANOVA and Post hoc Tukey
test (p<0.05). Data obtained from ADT test were analyzed using Kruskal-Wallis.
RESULTS: The percentage of colony-forming units reduction was (99.75, 99.98) in
Metronidazole, (99.66, 99.85) in CHX, and (96.68, 96.68) in Laser+Emundo (96.68,
96.68) groups after 24 and 48h, respectively. The amount of bacterial reduction in
terms of log10 CFU/mL was decreased in the Metronidazole, CHX, Laser+Emundo and,
Emundo groups, respectively after 48h (p<0.05). The inhibition zone radius was
decreased in CHX, Metronidazole and, Laser+Emundo, respectively (p<0.05).
CONCLUSIONS: It can be concluded that within the limitations of this in-vitro
study, although photodynamic therapy with Emundo reduced the amount of P.
gingivalis significantly, the use of metronidazole 2% in Orabase performed better
in terms of reducing the amount of the bacteria. Also, the antibacterial effect of
2% CHX gel on P. gingivalis was significantly more than photodynamic therapy with
Emundo.
AN - rayyan-563561119
AU - Fekrazad, R.
AU - Karamifar, K.
AU - Bahador, A.
CY - Netherlands
DO - 10.1016/j.pdpdt.2016.04.003
J2 - Photodiagnosis Photodyn Ther
KW - Anti-Bacterial Agents/administration & dosage
Cell Survival/drug effects/physiology/radiation effects
Dose-Response Relationship, Radiation
Drug Therapy, Combination/methods
Gels/administration & dosage
Humans
Indocyanine Green/*administration & dosage
Light
Metronidazole/*administration & dosage
Photochemotherapy/*methods
Photosensitizing Agents/administration & dosage
Porphyromonas gingivalis/*drug effects/physiology/*radiation effects
LA - eng
N1 - Periodontology Department, Dental Faculty - Laser Research Center in Medical
Sciences, AJA University of Medical Sciences, Tehran, Iran.; Department of
Endodontics, Faculty of Dentistry, Shiraz Branch, Islamic Azad University, Shiraz,
Iran. Electronic address: kasra.karamifar@gmail.com.; Department of Microbiology,
Laser Research Center, Dental Research Center, Dentistry Research Institute, School
of Medicine, Tehran University of Medical Sciences, Iran.
PY - 2016
SP - 28-33
ST - Comparison of antibacterial effect of photodynamic therapy using indocyanine
T2 - Photodiagnosis and photodynamic therapy
TI - Comparison of antibacterial effect of photodynamic therapy using indocyanine
VL - 15
Y2 - 9
ID - 14493
ER -
TY - JOUR
AB - Aim: To compare the clinical and microbiological effects of scaling and root
planing (SRP) alone or combined with mechanical [professional plaque control (PPC)]
or chemical [chlorhexidine rinsing (CHX)] control of supragingival plaque in the
treatment of chronic periodontitis. Material and Methods: Sixty subjects were
randomly assigned to receive SRP alone or combined with PPC (twice a week) or with
CHX rinsing (twice a day). The adjunctive treatments began with SRP and were
continued for 42 days. Clinical and microbiological examinations were performed at
baseline, 2 and 6 months post-therapy. Subgingival plaque samples were analysed for
38 bacterial species by checkerboard DNA-DNA hybridization. Results: The two test
treatments were more effective in improving probing depth and clinical attachment
level (CAL) than SRP alone, even in intermediate and deep sites. CAL gain was
better maintained in the CHX group. The most beneficial microbiological changes
were observed in CHX-treated subjects, who showed a significant reduction in the
proportions of red and orange complexes, as well as an increase in the proportions
of the host-compatible bacterial species. Conclusion: Strict plaque control
performed during and after SRP improves periodontal treatment outcomes. The
greatest microbiological and clinical benefits were observed with the use of CHX
rinsing. © 2009 John Wiley & Sons A/S.
AN - rayyan-563560662
AU - Feres, M.
AU - Gursky, L. C.
AU - Faveri, M.
AU - Tsuzuki, C. O.
DO - 10.1111/j.1600-051X.2009.01471.x
IS - 10
KW - bacterial DNA
chlorhexidine
fluoride
mouthwash
placebo
silicic acid
toothpaste
triclosan
adult
article
bacterial count
bacterium
classification
clinical trial
comparative study
controlled study
drug mixture
female
gingiva bleeding
human
male
microbiology
middle aged
mouth hygiene
nucleic acid hybridization
periodontal disease
periodontal pocket
tooth plaque
treatment outcome
LA - English
PY - 2009
SN - ["0303-6979", "1600-051X"]
SP - 857-867
ST - Clinical and microbiological benefits of strict supragingival plaque control
as part of the active phase of periodontal therapy
TI - Clinical and microbiological benefits of strict supragingival plaque control
as part of the active phase of periodontal therapy
VL - 36
ID - 14036
ER -
TY - JOUR
AB - Background: This study aimed to evaluate the in vitro color of dental enamel
bleached with the violet LED, associated with or without low-concentration of
peroxide; analyzed in two time intervals: 24 h later and 6 months after the
treatment. Methods: Ninety fragments of bovine teeth (6 × 6 mm and 3 mm thick) were
randomly divided into 6 groups according to bleaching treatment: NB – no bleaching,
VL – Violet LED, HP- 7.5 % hydrogen peroxide, HP + VL – 7.5 % hydrogen peroxide +
violet LED, CP – 22 % carbamide peroxide, CP + VL – 22 % carbamide peroxide +
violet LED. The color change was analyzed by using a spectrophotometer, at time
intervals of 24 h and 6 months after performing the bleaching techniques (n = 12).
Scanning electron microscopy (SEM) was performed to verify the enamel surface
morphology after treatment (n = 3). Results: The color change data were analyzed
using ANOVA and a post-hoc Tukey tests (α = 0.05). The VL group showed chromatic
changes after 24 h of treatment, however the groups submitted to bleaching gel
treatments associated with or without violet LED (CP + VL, CP, HP, HP + VL) showed
the highest color change values at all time intervals analyzed, with color
stability after 6 months of treatment for the CP + VL group. Scanning electron
microscopy analysis showed the greatest change in enamel surface for Groups CP and
HP. Conclusions: It could be concluded that violet LED had immediate bleaching
effect without promoting significant changes in enamel morphology, however the
association with carbamide peroxide 22 % showed color stability and greater
bleaching efficacy than the use of violet LED alone, after 6 months.
AN - rayyan-563560015
AU - Fernandes, B. M.
AU - Tanaka, M. H.
AU - De Oliveira, A. L. B. M.
AU - Scatolin, R. S.
DO - 10.1016/j.pdpdt.2020.102101
KW - EVO 50
dental light
periodontal curette
SP62S
spectrophotometer
carbamide peroxide
gel
hydrogen peroxide
peroxide
animal tissue
article
bleaching
bovine
concentration ratio
controlled study
dental procedure
enamel
nonhuman
post hoc analysis
priority journal
surface property
LA - English
PY - 2021
SN - ["1873-1597", "1572-1000"]
ST - Color stability of dental enamel bleached with violet LED associated with or
without Low concentration peroxide gels
TI - Color stability of dental enamel bleached with violet LED associated with or
without Low concentration peroxide gels
VL - 33
ID - 13389
ER -
TY - CHAP
AN - rayyan-563561684
AU - Fernandes, T.
AU - D'Souza, A. D.
AU - Sawarkar, S. P.
DO - 10.1002/9781119618973.ch16
PY - 2020
SP - 259-269
ST - Ocimum sanctum L: Promising agent for oral health care management
T2 - Natural Oral Care in Dental Therapy
TI - Ocimum sanctum L: Promising agent for oral health care management
85102744625&doi=10.1002%2f9781119618973.ch16&partnerID=40&md5=91f6c2426024f799a0387
04db039b57e
ID - 15058
ER -
TY - JOUR
AB - This study aimed to explore the effect of topically administering an orabase
gel containing cashew gum (CG), a complex polysaccharide from Anacardium
occidentale L., on the transcription of important proinflammatory (COX-2, NOS-2,
INF-γ OSCAR, and MYD88) and anti-inflammatory genes (IL-10, IL-4, and TGFβ1) in the
gingival tissues of rats with ligature-induced periodontitis, compared to the
effect observed upon topically applying a well-known antibiofilm agent
(chlorhexidine) under the same experimental conditions. The gene expression profile
in the gingival tissues of rats with periodontitis treated with CG did not
statistically significantly differ from that observed in the group of animals
treated with chlorhexidine. Results showed that CG is able to attenuate general
inflammation in the periodontium by reducing the transcription of proinflammatory
mediators in a MYD88-independent manner, and not by inducing the expression of
anti-inflammatory factors. In conclusion, this study demonstrated that CG and
chlorhexidine treatment reduced significantly the gene overexpression (COX-2, NOS-
2, INF-γ OSCAR, and TGFβ1) in the model of ligature-induced periodontitis.
AN - rayyan-563560189
AU - Ferreira-Fernandes, H.
AU - Barros, M. A. L.
AU - Souza Filho, M. D.
AU - Medeiros, J. V. R.
AU - Silva, D. A.
AU - Leódido, A. C. M.
AU - Silva, F. R. P.
AU - França, L. F. C.
AU - Di Lenardo, D.
AU - Yoshioka, F. K. N.
AU - Rey, J. A.
AU - Burbano, R. R.
AU - Pinto, G. R.
DO - 10.1016/j.ijbiomac.2019.02.002
cashew gum
chlorhexidine
cyclooxygenase 2
gamma interferon
interleukin 10
interleukin 4
orabase
unclassified drug
animal experiment
animal model
animal tissue
article
controlled study
COX 2 gene
cytokine production
drug effect
drug formulation
female
gene
gene overexpression
gingival tissue
host bacterium interaction
IL 10 gene
IL 4 gene
INF gamma gene
MYD88 gene
nonhuman
NOS 2 gene
OSCAR gene
periodontitis
rat
TGF beta 1 gene
treatment response
Wistar rat
LA - English
PY - 2019
SN - ["1879-0003", "0141-8130"]
SP - 934-940
ST - Topical application of cashew gum or chlorhexidine gel reduces overexpression
of proinflammatory genes in experimental periodontitis
T2 - Int. J. Biol. Macromol.
TI - Topical application of cashew gum or chlorhexidine gel reduces overexpression
VL - 128
ID - 13563
ER -
TY - JOUR
AB - This study aimed to explore the effect of topically administering an orabase
gel containing cashew gum (CG), a complex polysaccharide from Anacardium
occidentale L, on the transcription of important proinflammatory (COX-2, NOS-2,
INF-gamma, OSCAR, and MYD88) and anti-inflammatory genes (IL-10, IL-4, and TGF beta
1) in the gingival tissues of rats with ligature-induced periodontitis, compared to
the effect observed upon topically applying a well-known antibiofilm agent
(chlorhexidine) under the same experimental conditions. The gene expression profile
in the gingival tissues of rats with periodontitis treated with CG did not
statistically significantly differ from that observed in the group of animals
treated with chlorhexidine. Results showed that CG is able to attenuate general
inflammation in the periodontium by reducing the transcription of proinflammatory
mediators in a MYD88-independent manner, and not by inducing the expression of
anti-inflammatory factors. In conclusion, this study demonstrated that CG and
chlorhexidine treatment reduced significantly the gene overexpression (COX-2, NOS-
2, INF-gamma, OSCAR, and TGF beta 1) in the model of ligature-induced
periodontitis. (C) 2019 Elsevier B.V. All rights reserved.
AN - rayyan-563562392
AU - Ferreira-Fernandes, H.
AU - Barros, M. A. L.
AU - Souza, M. D.
AU - Medeiros, J. V. R.
AU - Silva, D. A.
AU - Leodido, A. C. M.
AU - Silva, F. R. P.
AU - Franca, L. F. C.
AU - Di Lenardo, D.
AU - Yoshioka, F. K. N.
AU - Rey, J. A.
AU - Burbano, R. R.
AU - Pinto, G. R.
DO - 10.1016/j.ijbiomac.2019.02.002
PY - 2019
SN - ["0141-8130", "1879-0003"]
SP - 934-940
ST - Topical application of cashew gum or chlorhexidine gel reduces overexpression
TI - Topical application of cashew gum or chlorhexidine gel reduces overexpression
VL - 128
Y2 - 5 y3 - 1
ID - 15766
ER -
TY - JOUR
AB - Streptococcus dentisani 7746, isolated from dental plaque of caries-free
individuals, has been shown to have several beneficial effects in vitro which could
contribute to promote oral health, including an antimicrobial activity against oral
pathogens by the production of bacteriocins and a pH buffering capacity through
ammonia production. Previous work has shown that S. dentisani was able to colonize
the oral cavity for 2–4 weeks after application. The aim of the present work was to
evaluate its clinical efficacy by a randomized, double-blind, placebo-controlled
parallel group study. Fifty nine volunteers were enrolled in the study and randomly
assigned to a treatment or placebo group. The treatment consisted of a bucco-
adhesive gel application (2.5 109 cfu/dose) with a dental splint for 5 min every 48
h, for a period of 1 month (i.e., 14 doses). Dental plaque and saliva samples were
collected at baseline, 15 and 30 days after first application, and 15 days after
the end of treatment. At baseline, there was a significant correlation between S.
dentisani levels and frequency of toothbrushing. Salivary flow, a major factor
influencing oral health, was significantly higher in the probiotic group at day 15
compared with the placebo (4.4 and 3.4 ml/5 min, respectively). In the probiotic
group, there was a decrease in the amount of dental plaque and in gingival
inflammation, but no differences were observed in the placebo group. The probiotic
group showed a significant increase in the levels of salivary ammonia and calcium.
Finally, Illumina sequencing of plaque samples showed a beneficial shift in
bacterial composition at day 30 relative to baseline, with a reduction of several
cariogenic organisms and the key players in plaque formation, probably as a result
of bacteriocins production. Only 58% of the participants in the probiotic group
showed increased plaque levels of S. dentisani at day 30 and 71% by day 45,
indicating that the benefits of S. dentisani application could be augmented by
improving colonization efficiency. In conclusion, the application of S. dentisani
7746 improved several clinical and microbiological parameters associated with oral
health, supporting its use as a probiotic to prevent tooth decay.
AN - rayyan-563560106
AU - Ferrer, M. D.
AU - López-López, A.
AU - Nicolescu, T.
AU - Perez-Vilaplana, S.
AU - Boix-Amorós, A.
AU - Dzidic, M.
AU - Garcia, S.
AU - Artacho, A.
AU - Llena, C.
AU - Mira, A.
DO - 10.3389/fcimb.2020.00465
KW - NCT03468842
Compact IC Plus 882
dental splint
adhesive agent
ammonia
bacteriocin
calcium
DNA 16S
probiotic agent
adult
aged
article
colony forming unit
controlled study
data analysis
DNA extraction
female
follow up
gene amplification
gene sequence
gingival index
gingivitis
human
illumina sequencing
ion chromatography
male
mouth hygiene
nonhuman
pH measurement
plaque index
reflectometry
saliva analysis
salivation
sample size
Streptococcus
Streptococcus dentisani
tooth brushing
tooth plaque
LA - English
PY - 2020
SN - 2235-2988
ST - Topic Application of the Probiotic Streptococcus dentisani Improves Clinical
and Microbiological Parameters Associated With Oral Health
T2 - Front. Cell. Infect. Microbiol.
TI - Topic Application of the Probiotic Streptococcus dentisani Improves Clinical
and Microbiological Parameters Associated With Oral Health
VL - 10
ID - 13480
ER -
TY - JOUR
AB - Dental plaque (DP) is found on the surface of teeth and comprises a community
of microorganisms that form a structured biofilm. Bacteria present in DP are
potential periodontal pathogens when there is an imbalance in the healthy oral
environment, and are precursors of periodontal disease (PD). In dogs, the
treatments, such as mechanical removal, are difficult and expensive to apply.
Therefore, in order to seek new therapeutic alternatives to control dental plaque
in dogs, Brazilian red propolis ethanol extract (RPEE) was tested to evaluate its
antibacterial effect on bacteria isolated from DP of dogs without PD. DP was
collected from the supragingival dental surfaces of 10 dogs. Bacterial isolates of
DP were identified by PCR and sequencing of 16S rDNA gene. The RPEE was obtained
using the ultrasound ethanol extraction technique, and the chemical composition was
obtained by HPLC-DAD and UV-spectrophotometry. In total, 29 different bacteria
belonging to five genera were identified. Formononetin, biochanin A, liquiritigenin
and daidzein were the major constituents of the RPEE. The cytotoxic effect showed
cell viability after 24 h above 50 % at all concentrations evaluated. The minimum
inhibitory concentration was between 37.5 and 150.0 µg/mL for all bacterial
isolates. The minimal bactericidal concentration was between 150 and 1200 µg/mL for
Gram-positive and 300–1200 µg/mL for Gram-negative bacteria. The results are
promising and suggest that RPEE has significant antibacterial potential against the
bacteria present in the DP of healthy dogs. Although further studies are still
needed, the results suggest RPEE might be safely used in the prevention of
periodontal disease.
AN - rayyan-563559763
AU - Figueiredo, C. G. F.
AU - Santos, M. S. D.
AU - Santos, A. S.
AU - Silva, E. D. S.
AU - Lima, B.
AU - Lucca Junior, W. D.
AU - Araujo, Y. L. F. M. D.
AU - Batista, M. V. D. A.
DO - 10.1016/j.cimid.2022.101924
KW - genetic analyzer
agar
antiinfective agent
biochanin A
chlorhexidine
daidzein
DNA 16S
formononetin
liquiritigenin
propolis extract
RNA 16S
agar diffusion
animal experiment
animal model
article
Bacillus cereus
bacterial growth
bacterium isolate
bacterium isolation
biofilm
Brazilian
broth dilution
Candida albicans
canine tooth
cell viability
clinical evaluation
controlled study
DNA extraction
DNA isolation
dog
Enterobacter aerogenes
Escherichia coli
gel electrophoresis
gene amplification
Lactobacillus plantarum
mass spectrometry
MTT assay
nonhuman
periodontal disease
phylogenetic tree
Proteobacteria
Salmonella enterica serovar Typhimurium
sequence alignment
spectrophotometry
tooth plaque
zone of inhibition
LA - English
PY - 2023
SN - ["1878-1667", "0147-9571"]
ST - In vitro evaluation of the antibacterial effect of Brazilian red propolis
ethanol extract in the prevention of periodontal disease in dogs
T2 - Comp. Immunol. Microbiol. Infect. Dis.
TI - In vitro evaluation of the antibacterial effect of Brazilian red propolis
ethanol extract in the prevention of periodontal disease in dogs
VL - 92
ID - 13137
ER -
TY - JOUR
AB - The concept of locally-delivering chemotherapeutic agents to the periodontal
pocket as a method to treat periodontal disease has been studied for over 20 years.
A number of locally-delivered chemotherapeutic agents in periodontal therapy are
either currently available or under in investigation. Clinical efficacy derives
from sustained-release technology to maintain an effective concentration of drug
within the periodontal pocket for a clinically relevant length of time. Studied
drugs have mainly been antimicrobials, both antibiotics and antiseptics. Most
agents have been tested as adjuncts to scaling and root planing; a few have been
studied as stand-alone monotherapies. Collectively, the data indicate that the use
of locally-delivered antimicrobials as adjuncts results in a significant increase
in the reduction of probing depth compared with scaling and root planing alone. In
other trials, results in reducing probing depth following the use of stand-alone
locally-delivered antimicrobials have been equivalent to those of scaling and root
planing over a specified time. This Symposium was organized to present the current
state-of-the-art with regard to the use of locally-delivered antimicrobials in the
treatment of periodontal disease. 5 experts in the field who have had considerable
experience in studying locally-delivered antimicrobials presented data. These
speakers reviewed the clinical findings regarding efficacy of 5 different
antimicrobial agents. An ensuing panel discussion was to consider treatment
recommendations for locally-delivered antimicrobials.
AN - rayyan-563562354
AU - Finkelman, R. D.
AU - Williams, R. C.
DO - 10.1111/j.1600-051X.1998.tb02395.x
IS - 11
PY - 1998
SN - ["0303-6979", "1600-051X"]
SP - 943-946
ST - Local delivery of chemotherapeutic agents in periodontal therapy: Has its
time arrived?
TI - Local delivery of chemotherapeutic agents in periodontal therapy: Has its
time arrived?
VL - 25
Y2 - 11
ID - 15728
ER -
TY - JOUR
AN - rayyan-563561208
AU - Firu, P.
AU - Stanciu, D.
AU - Zane, P.
IS - 4
cetalkonium halide
mundisal
unclassified drug
drug therapy
gingivitis
mouth ulcer
stomatitis
therapy
LA - German
PY - 1976
SP - 111-116
ST - The therapeutical value of Mundisal, gel and solution, in the treatment of
lesions of the buccal mucosa
T2 - THERAPEUTISCHER WERT VON 'MUNDISAL' GEL UND LOSUNG IN DER BEHANDLUNG VON
VERLETZUNGEN DER MUNDSCHLEIMHAUT
TI - The therapeutical value of Mundisal, gel and solution, in the treatment of
lesions of the buccal mucosa
VL - 65
ID - 14582
ER -
TY - JOUR
AB - Oral mucosal and salivary lipids exhibit potent antimicrobial activity for a
variety of Gram-positive and Gram-negative bacteria; however, little is known about
their spectrum of antimicrobial activity or mechanisms of action against oral
bacteria. In this study, we examine the activity of two fatty acids and three
sphingoid bases against Porphyromonas gingivalis, an important colonizer of the
oral cavity implicated in periodontitis. Minimal inhibitory concentrations, minimal
bactericidal concentrations, and kill kinetics revealed variable, but potent,
activity of oral mucosal and salivary lipids against P. gingivalis, indicating that
lipid structure may be an important determinant in lipid mechanisms of activity
against bacteria, although specific components of bacterial membranes are also
likely important. Electron micrographs showed ultrastructural damage induced by
sapienic acid and phytosphingosine and confirmed disruption of the bacterial plasma
membrane. This information, coupled with the association of treatment lipids with
P. gingivalis lipids revealed via thin layer chromatography, suggests that the
plasma membrane is a likely target of lipid antibacterial activity. Utilizing a
combination of two-dimensional in-gel electrophoresis and Western blot followed by
mass spectroscopy and N-terminus degradation sequencing we also show that treatment
with sapienic acid induces upregulation of a set of proteins comprising a unique P.
gingivalis stress response, including proteins important in fatty acid
biosynthesis, metabolism and energy production, protein processing, cell adhesion
and virulence. Prophylactic or therapeutic lipid treatments may be beneficial for
intervention of infection by supplementing the natural immune function of
endogenous lipids on mucosal surfaces. © 2013 WCSS.
AN - rayyan-563560472
AU - Fischer, C. L.
AU - Walters, K. S.
AU - Drake, D. R.
AU - Dawson, D. V.
AU - Blanchette, D. R.
AU - Brogden, K. A.
AU - Wertz, P. W.
DO - 10.1038/ijos.2013.28
IS - 3
bacterial protein
fatty acid
lipid
sphingolipid
article
bacterial count
chemistry
drug effect
electron microscopy
human
immunology
microbiology
mouth mucosa
saliva
ultrastructure
virulence
LA - English
PY - 2013
SN - ["1674-2818", "2049-3169"]
SP - 130-140
ST - Oral mucosal lipids are antibacterial against Porphyromonas gingivalis,
induce ultrastructural damage, and alter bacterial lipid and protein compositions
T2 - Int. J. Oral Sci.
TI - Oral mucosal lipids are antibacterial against Porphyromonas gingivalis,
induce ultrastructural damage, and alter bacterial lipid and protein compositions
VL - 5
ID - 13846
ER -
TY - JOUR
AB - The percutaneous device dilemma describes etiological factors, centered
around the disrupted epithelial tissue surrounding non-remodelable devices, that
contribute to rampant percutaneous device infection. Natural percutaneous organs,
in particular their extracellular matrix mediating the “device”/epithelium
interface, serve as exquisite examples to inspire longer lasting long-term
percutaneous device design. For example, the tooth's imperviousness to infection is
mediated by the epithelium directly surrounding it, the junctional epithelium (JE).
The hallmark feature of JE is formation of hemidesmosomes, cell/matrix adhesive
structures that attach surrounding oral gingiva to the tooth's enamel through a
basement membrane. Here, the authors survey the multifaceted functions of the JE,
emphasizing the role of the matrix, with a particular focus on hemidesmosomes and
their five main components. The authors highlight the known (and unknown) effects
dental implant – as a model percutaneous device – placement has on JE regeneration
and synthesize this information for application to other percutaneous devices. The
authors conclude with a summary of bioengineering strategies aimed at solving the
percutaneous device dilemma and invigorating greater collaboration between
clinicians, bioengineers, and matrix biologists.
AN - rayyan-563559784
AU - Fischer, N. G.
AU - Aparicio, C.
DO - 10.1016/j.bioactmat.2022.03.019
KW - implant
surgical tape
tooth implant
amoxicillin
calcitonin gene related peptide
calgranulin
calponin
carcinoembryonic antigen related cell adhesion molecule 1
collagen
cytokeratin 5
dystrophin
entactin
epidermal growth factor receptor
hyaluronic acid
hydrogel
hydroxyapatite
integrin
interleukin 8
leukocyte elastase
linoleic acid
microRNA
molybdenum
myosin II
myosin light chain
paxillin
plectin
plexin
Rho guanine nucleotide binding protein
scatter factor
spectrin
syndecan 1
tamoxifen
vasculotropin
basement membrane
biocompatibility
biomechanics
device infection
enamel
epithelium
gap junction
gingivitis
hemidesmosome
laminitis
nonhuman
review
tissue regeneration
tooth development
wound healing
LA - English
PY - 2022
SN - 2452-199X
SP - 178-198
ST - Junctional epithelium and hemidesmosomes: Tape and rivets for solving the
“percutaneous device dilemma” in dental and other permanent implants
T2 - Bioact. Mater.
TI - Junctional epithelium and hemidesmosomes: Tape and rivets for solving the
“percutaneous device dilemma” in dental and other permanent implants
VL - 18
ID - 13158
ER -
TY - JOUR
AB - In situ forming implants (ISIs) formed from poly(lactic-co-glycolic acid)
(PLGA) have been commercialized for local drug delivery to treat periodontitis, but
drug release from these bulk materials is typically subject to an initial burst. In
addition, PLGA has inferior material properties for the dynamic mechanical
environment of gingival tissue. In this work, poly(beta-amino ester) (PBAE)
hydrogel microparticles were incorporated into a PLGA matrix to provide several new
functions: mechanical support, porosity, space-filling, and controlled co-delivery
of antimicrobial and osteogenic drugs. First, the effects of PBAE microparticles on
ISI architecture and material properties throughout degradation were investigated.
Second, the influence of PBAE microparticles on drug release kinetics was
quantified. Over a 15 d period, ISIs containing PBAE microparticles possessed
greater porosity, ranging from 42-80%, compared to controls, which ranged from 24-
54% (p < 0.001), and these ISIs also developed significantly greater accessible
volume to simulated cell-sized spheres after 5 d or more of degradation (p <
0.001). PBAE-containing ISIs possessed a more uniform microarchitecture, which
preserved mechanical resilience after cyclical loading (p < 0.001), and the
materials swelled to fill the injected space, which significantly increased
interfacial strength in an artificial periodontal pocket (p < 0.0001). PBAE
microparticles eliminated the burst of freely-mixed simvastatin compared to 36%
burst from controls (p < 0.0001), and high-dose doxycycline release was prolonged
from 2 d to 7 d by pre-loading drug into the microparticles. PBAE-containing PLGA
ISIs are more effective space-filling scaffolds and offer improved release kinetics
compared to existing ISIs used to treat periodontitis.
AN - rayyan-563562243
AU - Fisher, P. D.
AU - Clemens, J.
AU - Hilt, J. Z.
AU - Puleo, D. A.
DO - 10.1088/1748-6041/11/2/025002
IS - 2
PY - 2016
SN - ["1748-6041", "1748-605X"]
ST - Multifunctional poly(beta-amino ester) hydrogel microparticles in periodontal
in situ forming drug delivery systems
T2 - BIOMEDICAL MATERIALS
TI - Multifunctional poly(beta-amino ester) hydrogel microparticles in periodontal
in situ forming drug delivery systems
VL - 11
Y2 - 4
ID - 15617
ER -
TY - JOUR
AB - In situ forming implants (ISIs) formed from poly(lactic-co-glycolic acid)
(PLGA) have been commercialized for local drug delivery to treat periodontitis, but
drug release from these bulk materials is typically subject to an initial burst. In
addition, PLGA has inferior material properties for the dynamic mechanical
environment of gingival tissue. In this work, poly(β-amino ester) (PBAE) hydrogel
microparticles were incorporated into a PLGA matrix to provide several new
functions: mechanical support, porosity, space-filling, and controlled co-delivery
of antimicrobial and osteogenic drugs. First, the effects of PBAE microparticles on
ISI architecture and material properties throughout degradation were investigated.
Second, the influence of PBAE microparticles on drug release kinetics was
quantified. Over a 15 d period, ISIs containing PBAE microparticles possessed
greater porosity, ranging from 42-80%, compared to controls, which ranged from 24-
54% (p < 0.001), and these ISIs also developed significantly greater accessible
volume to simulated cell-sized spheres after 5 d or more of degradation (p <
0.001). PBAE-containing ISIs possessed a more uniform microarchitecture, which
preserved mechanical resilience after cyclical loading (p < 0.001), and the
materials swelled to fill the injected space, which significantly increased
interfacial strength in an artificial periodontal pocket (p < 0.0001). PBAE
microparticles eliminated the burst of freely-mixed simvastatin compared to 36%
burst from controls (p < 0.0001), and high-dose doxycycline release was prolonged
from 2 d to 7 d by pre-loading drug into the microparticles. PBAE-containing PLGA
ISIs are more effective space-filling scaffolds and offer improved release kinetics
compared to existing ISIs used to treat periodontitis.
AN - rayyan-563560350
AU - Fisher, P. D.
AU - Clemens, J.
AU - Zach Hilt, J.
AU - Puleo, D. A.
DO - 10.1088/1748-6041/11/2/025002
IS - 2
KW - doxycycline hyclate
poly(beta amino ester)
polyglactin
polymer
simvastatin
unclassified drug
article
controlled study
drug degradation
drug megadose
drug release
hydrogel
in situ forming implant
porosity
strength
LA - English
PY - 2016
SN - ["1748-605X", "1748-6041"]
ST - Multifunctional poly(β-amino ester) hydrogel microparticles in periodontal in
situ forming drug delivery systems
T2 - Biomed. Mater.
TI - Multifunctional poly(β-amino ester) hydrogel microparticles in periodontal in
situ forming drug delivery systems
VL - 11
ID - 13724
ER -
TY - JOUR
AN - rayyan-563561078
AU - Flemmig, T. F.
AU - Miyasaki, K. T.
DO - 10.1111/j.1399-302X.1994.tb00070.x
IS - 5
KW - alpha defensin
cathepsin
cathepsin G
defensin
defensin 1
defensin 2
defensin 3
isoenzyme
pancreatic elastase
plasma protein
proteinase
serine proteinase
adult
article
blood
chemistry
enzymology
female
human
immunology
male
metabolism
neutrophil
periodontitis
serum bactericidal activity
LA - English
PY - 1994
SN - 0902-0055
SP - 272-277
ST - Neutrophil lysosomal nonoxidative microbicidal proteins in early-onset
periodontitis
T2 - ORAL MICROBIOL. IMMUNOL.
TI - Neutrophil lysosomal nonoxidative microbicidal proteins in early-onset
periodontitis
VL - 9
ID - 14452
ER -
TY - JOUR
AB - BACKGROUND: Moxifloxacin exerts excellent antibacterial activity against most
putative periodontal pathogens and has been shown to kill bacteria in biofilm and
host cells. METHODS: Patients with chronic periodontitis were randomly assigned to
receive a single subgingival application of a 0.125%, 0.4%, or 1.25% moxifloxacin
gel or placebo gel immediately after full-mouth scaling and root planing (SRP).
Clinical efficacy measurements were assessed in sites with baseline probing depth
(PD) of ≥5.4 mm at 6 weeks and 3 months and any adverse events were determined. In
addition, putative periodontal pathogens and resistance of subgingival bacteria
against moxifloxacin were assessed. RESULTS: Data of 57 patients were included in
the statistical analysis. In all treatment groups, the PD decreased from baseline
to 3 months, with the greatest reduction seen in patients treated with moxifloxacin
0.4% (1.5 ± 0.6 mm; P = 0.023 compared to placebo), followed by patients receiving
moxifloxacin 1.25% (1.2 ± 0.4), moxifloxacin 0.125% (1.1 ± 1.1), and placebo (1.0 ±
0.6). No linear trend for PD reduction with increasing moxifloxacin concentrations
was found. Porphyromonas gingivalis showed the greatest reduction in prevalence
among the assessed pathogens, without any significant intergroup differences. No
correlation or systematic relationship between adverse events, including bacterial
resistance against moxifloxacin, and the investigational gels was found.
CONCLUSIONS: In periodontal pockets with PD of ≥5.4 mm, a single subgingival
administration of a 0.4% moxifloxacin gel as an adjunct to SRP may result in
additional PD reduction compared to SRP alone. In addition, the investigated
moxifloxacin gels seem to be safe.
AN - rayyan-563561132
AU - Flemmig, T. F.
AU - Petersilka, G.
AU - Völp, A.
AU - Gravemeier, M.
AU - Zilly, M.
AU - Mross, D.
AU - Prior, K.
AU - Yamamoto, J.
AU - Beikler, T.
DO - 10.1902/jop.2010.100124
IS - 1
J2 - J Periodontol
Adult
Aged
Aggregatibacter actinomycetemcomitans/drug effects
Anti-Infective Agents/*administration & dosage
Aza Compounds/*administration & dosage
Bacterial Load
Bacteroides/drug effects
Chronic Periodontitis/drug therapy/microbiology/*therapy
Dental Plaque/microbiology
Dental Scaling
Drug Resistance, Bacterial
Female
Fluoroquinolones
Follow-Up Studies
Gingival Recession/drug therapy/therapy
Humans
Male
Middle Aged
Moxifloxacin
Periodontal Attachment Loss/drug therapy/microbiology/therapy
Periodontal Pocket/drug therapy/microbiology/therapy
Placebos
Porphyromonas gingivalis/drug effects
Quinolines/*administration & dosage
Root Planing
Safety
Streptococcus intermedius/drug effects
Treatment Outcome
Treponema denticola/drug effects
LA - eng
N1 - Department of Periodontics, School of Dentistry, University of Washington,
Seattle, WA 98195–7444, USA. flemmig@u.washington.edu
PY - 2011
SP - 96-105
ST - Efficacy and safety of adjunctive local moxifloxacin delivery in the
treatment of periodontitis
TI - Efficacy and safety of adjunctive local moxifloxacin delivery in the
VL - 82
Y2 - 1
ID - 14506
ER -
TY - JOUR
AB - Background: Moxifloxacin exerts excellent antibacterial activity against most
host cells. Methods: Patients with chronic periodontitis were randomly assigned to
(PD) of >= 5.4 mm at 6 weeks and 3 months and any adverse events were determined.
In addition, putative periodontal pathogens and resistance of subgingival bacteria
against moxifloxacin were assessed. Results: Data of 57 patients were included in
0.4% (1.5 +/- 0.6 mm; P = 0.023 compared to placebo), followed by patients
receiving moxifloxacin 1.25% (1.2 +/- 0.4), moxifloxacin 0.125% (1.1 +/- 1.1), and
placebo (1.0 +/- 0.6). No linear trend for PD reduction with increasing
moxifloxacin concentrations was found. Porphyromonas gingivalis showed the greatest
reduction in prevalence among the assessed pathogens, without any significant
intergroup differences. No correlation or systematic relationship between adverse
events, including bacterial resistance against moxifloxacin, and the
investigational gels was found. Conclusions: In periodontal pockets with PD of >=
5.4 mm, a single subgingival administration of a 0.4% moxifloxacin gel as an
adjunct to SRP may result in additional PD reduction compared to SRP alone. In
addition, the investigated moxifloxacin gels seem to be safe. J Periodontol
2017;82:96-105.
AN - rayyan-563562217
AU - Flemmig, T. F.
AU - Petersilka, G.
AU - Volp, A.
AU - Gravemeier, M.
AU - Zilly, M.
AU - Mross, D.
AU - Prior, K.
AU - Yamamoto, J.
AU - Beikler, T.
DO - 10.1902/jop.2010.100124
IS - 1
PY - 2011
SN - ["0022-3492", "1943-3670"]
SP - 96-105
ST - Efficacy and Safety of Adjunctive Local Moxifloxacin Delivery in the
Treatment of Periodontitis
TI - Efficacy and Safety of Adjunctive Local Moxifloxacin Delivery in the
Treatment of Periodontitis
VL - 82
Y2 - 1
ID - 15591
ER -
TY - JOUR
AB - Background: Moxifloxacin exerts excellent antibacterial activity against most
host cells. Methods: Patients with chronic periodontitis were randomly assigned to
(PD) of ≥5.4 mm at 6 weeks and 3 months and any adverse events were determined. In
addition, putative periodontal pathogens and resistance of subgingival bacteria
against moxifloxacin were assessed. Results: Data of 57 patients were included in
0.4% (1.5 ± 0.6 mm; P = 0.023 compared to placebo), followed by patients receiving
moxifloxacin 1.25% (1.2 ± 0.4), moxifloxacin 0.125% (1.1 ± 1.1), and placebo (1.0 ±
0.6). No linear trend for PD reduction with increasing moxifloxacin concentrations
was found. Porphyromonas gingivalis showed the greatest reduction in prevalence
among the assessed pathogens, without any significant intergroup differences. No
correlation or systematic relationship between adverse events, including bacterial
resistance against moxifloxacin, and the investigational gels was found.
Conclusions: In periodontal pockets with PD of ≥5.4 mm, a single subgingival
administration of a 0.4% moxifloxacin gel as an adjunct to SRP may result in
additional PD reduction compared to SRP alone. In addition, the investigated
moxifloxacin gels seem to be safe.
AN - rayyan-563560605
AU - Flemmig, T. F.
AU - Petersilka, G.
AU - Völp, A.
AU - Gravemeier, M.
AU - Zilly, M.
AU - Mross, D.
AU - Prior, K.
AU - Yamamoto, J.
AU - Beikleri, T.
DO - 10.1902/jop.2010.100124
IS - 1
heterocyclic compound
moxifloxacin
placebo
quinoline derivative
adult
aged
article
bacterial load
Bacteroides
clinical trial
comparative study
controlled study
drug effect
female
follow up
gingiva bleeding
gingiva disease
human
male
microbiology
middle aged
periodontal disease
periodontal pocket
phase 2 clinical trial
safety
Streptococcus intermedius
tooth plaque
treatment outcome
Treponema denticola
LA - English
PY - 2011
SN - 0022-3492
SP - 96-105
ST - Efficacy and safety of adjunctive local moxifloxacin delivery in the
TI - Efficacy and safety of adjunctive local moxifloxacin delivery in the
VL - 82
ID - 13979
ER -
TY - JOUR
AB - In this short paper some data from clinical use of chlorhexidine outside
dental institutions are presented. In these trials chlorhexidine mouthwashes,
chlorhexidine dentifrices and chlorhexidine gel in cap splints have been utilized.
Some comments were made upon related side effects.
AN - rayyan-563561215
AU - Flotra, L.
chlorhexidine
drug
placebo
toothpaste
gingiva
mouth hygiene
tooth
tooth plaque
LA - English
PY - 1973
SN - 0022-3484
SP - 41-44
ST - Different modes of chlorhexidine application and related local side effects
TI - Different modes of chlorhexidine application and related local side effects
ID - 14589
ER -
TY - JOUR
AB - Protein and peptide-based therapeutic agents have unique physiochemical
properties such as high molecular weight, short half life, requirement of a
sustained plasma level for the desired therapeutic effect, liable to physical and
chemical instability by gastric enzymes and harsh acidic environment as well as
first pass metabolism, which makes their delivery a challenge. The delivery of
proteins and peptides using various routes of administration like oral, nasal,
rectal, pulmonary, buccal, vaginal and transdermal route is found to exhibit
limitations, poor permeability and degradation being major limitations. Use of
parenteral route is found to overcome these problems but patient compliance is poor
due to the need for frequent administration. Use of control delivery for these
drugs using smart polymers seems promising as they overcome the limitations posed
by other routes of delivery. Smart polymers increase patient compliance, maintain
stability of the drug, and maintain drug level in therapeutic window and are easy
to manufacture. Different types of smart polymerbased delivery systems, such as
sensitive to temperature, phase, pH, electric charge, light, and biochemicals, and
their application in controlling the release of the incorporated drug to obtain a
sustained plasma level has been discussed. Smart polymers, however, face challenges
with regard to high burst release, unpredictable behavior in later part of biphasic
release profile, overall drug release kinetics, conformational stability during
processing, and preserving biological activity after getting released. Several
patents overcoming these inherent problems associated with smart polymers have been
reviewed. At the end, the future direction and potential of smart polymer-based
delivery system for drug delivery has been presented in brief. © 2009 Bentham
Science Publishers Ltd.
AN - rayyan-563560657
AU - Fogueri, L. R.
AU - Singh, S.
DO - 10.2174/187221109787158300
IS - 1
atrigel
carbomer
concanavalin A
copolymer
doxycycline
drug carrier
glutaraldehyde
leuprorelin
liposome
microsphere
pantarin
peptide
pluronics
poloxamer
poloxamers
polymer
protein
regel
unclassified drug
biodegradability
drug conformation
drug efficacy
drug formulation
drug release
drug stability
electricity
enzyme degradation
heat sensitivity
human
hydrophobicity
immunogenicity
infection
ionization
kinetics
molecular weight
nanoencapsulation
pain
patent
periodontitis
pH
physical chemistry
priority journal
review
atridox
carbopol
eligard
nutropin depot
LA - English
PY - 2009
SN - 1872-2113
SP - 40-48
ST - Smart polymers for controlled delivery of proteins and peptides: A review of
patents
T2 - Recent Pat. Drug Deliv. Formulation
TI - Smart polymers for controlled delivery of proteins and peptides: A review of
patents
VL - 3
ID - 14031
ER -
TY - JOUR
AN - rayyan-563561184
AU - Fourel, J.
AU - Louise, F.
IS - 2
KW - chlorhexidine
placebo
adult
article
female
gel
gingivitis
human
male
tooth plaque
LA - French
PY - 1984
SN - 0750-1838
SP - 163-170
ST - Double blind study of the effect of a 0.2% chlorhexidine gel on gingival
inflammation
T2 - Etude en double aveugle de l'action d'un gel à 0.2% de chlorhexidine sur
l'inflammation gingivale.
TI - Double blind study of the effect of a 0.2% chlorhexidine gel on gingival
inflammation
VL - 3
ID - 14558
ER -
TY - JOUR
AB - The bacteriological colonization of healing periodontal defects was
investigated after treatment with guided tissue regeneration using expanded
polytetrafluoroethylene membranes together with local metronidazole gel (25%, 250
mg/g). Twelve patients, each with one pair of comparable defects, had the test
defect treated with the membrane plus metronidazole gel and the control defect
treated with the membrane alone. Thirty weeks after removal of the membrane, the
median gain in probing attachment level as a percentage of the initial defect depth
was 92% for the test defects and 50% for the control defects (P = 0.001). The
median number of cultivable bacteria decreased from 1.2 x 106 at the presurgical
examination to 3.0 x 105 at the one week examination in the test group (P = 0.02),
whereas an increase was observed in the control group. Similarly, a lower median
proportion of black-pigmented Gram-negative anaerobic rods was observed one week
postsurgically in the test group (0.0004%) compared to the control group (3.5%) (P
= 0.02). Two weeks after membrane insertion, and at all following examinations, no
microbiological differences between test and control group were observed.
Consequently, the influence of the metronidazole gel on the treatment result
appears to have been confined to the initial regeneration phase. Despite the good
clinical results in the test group, all membranes from both test and control
pockets were heavily colonized with bacteria at the time of removal. To ensure
maximal periodontal regeneration with formation of bone, future research in this
area should concentrate on reducing the microbial colonization of the wound area.
AN - rayyan-563561075
AU - Frandsen, E. V. G.
AU - Sander, L.
AU - Arnbjerg, D.
AU - Theilade, E.
DO - 10.1902/jop.1994.65.10.921
IS - 10
KW - metronidazole
adult
article
clinical article
human
periodontal disease
tissue regeneration
wound healing
LA - English
PY - 1994
SN - 0022-3492
SP - 921-928
ST - Effect of local metronidazole application on periodontal healing following
guided tissue regeneration. Microbiological findings
TI - Effect of local metronidazole application on periodontal healing following
guided tissue regeneration. Microbiological findings
VL - 65
ID - 14449
ER -
TY - JOUR
AB - The aims of endodontic treatment in cases of apical periodontitis are to
reduce as much as possible the number of microorganisms inside the root canal
system and to inactivate toxins produced by them. Most of the times, these
objectives are not achieved solely by chemomechanical preparation, and intracanal
dressing may be necessary. In these cases, calcium hydroxide is used as a root
canal dressing due to its well-known and recognized antimicrobial activity.
Chlorhexidine has a wide spectrum of antimicrobial activity and its association
with calcium hydroxide has been recommended in an attempt to amplify antimicrobial
effects of calcium hydroxide. It is also known that dentin exerts a buffering
effect under wide pH variations, and may be responsible for decreasing the
antimicrobial activity of drugs inside the root canal. The objectives of this study
were to assess the pH of 2% chlorhexidine gel and calcium hydroxide alone or in
combination, as well as the influence of dentin on the pH of these compounds.
Dentin powder was obtained from bovine teeth and added as 1.8% to the volume of the
medications. All substances were individually stored in plastic flasks, in
triplicate. A pH meter was used at five different moments to assess pH in viscous
medium: immediately after preparation and after 24 h, and 7, 14, and 21 days.
Results were analyzed by paired Student's t-test. Statistically significant
differences were observed in the 2% chlorhexidine gel group alone or associated
with calcium hydroxide and added of dentin powder (P < 0.05). Mean pH values
indicated the influence of dentin powder because of a significant increase in pH.
Calcium hydroxide with propylene glycol as the vehicle always showed high pH,
demonstrating that this compound was not affected by the presence of dentin. © 2010
John Wiley & Sons A/S.
AN - rayyan-563560640
AU - Freire, L. G.
AU - Carvalho, C. N.
AU - Ferrari, P. H. P.
AU - Siqueira, E. L.
AU - Gavini, G.
DO - 10.1111/j.1600-9657.2010.00874.x
IS - 3
buffer
calcium hydroxide
chlorhexidine
drug vehicle
propylene glycol
animal
article
bovine
chemistry
dentin
gel
pH
physiology
time
tooth pulp
vehicles
LA - English
PY - 2010
SN - ["1600-4469", "1600-9657"]
SP - 276-280
ST - Influence of dentin on pH of 2% chlorhexidine gel and calcium hydroxide alone
or in combination
T2 - Dent. Traumatol.
TI - Influence of dentin on pH of 2% chlorhexidine gel and calcium hydroxide alone
or in combination
VL - 26
ID - 14014
ER -
TY - JOUR
AB - The aims of endodontic treatment in cases of apical periodontitis are to
reduce as much as possible the number of microorganisms inside the root canal
system and to inactivate toxins produced by them. Most of the times, these
objectives are not achieved solely by chemomechanical preparation, and intracanal
dressing may be necessary. In these cases, calcium hydroxide is used as a root
canal dressing due to its well-known and recognized antimicrobial activity.
Chlorhexidine has a wide spectrum of antimicrobial activity and its association
with calcium hydroxide has been recommended in an attempt to amplify antimicrobial
effects of calcium hydroxide. It is also known that dentin exerts a buffering
effect under wide pH variations, and may be responsible for decreasing the
antimicrobial activity of drugs inside the root canal. The objectives of this study
were to assess the pH of 2% chlorhexidine gel and calcium hydroxide alone or in
combination, as well as the influence of dentin on the pH of these compounds.
Dentin powder was obtained from bovine teeth and added as 1.8% to the volume of the
medications. All substances were individually stored in plastic flasks, in
triplicate. A pH meter was used at five different moments to assess pH in viscous
medium: immediately after preparation and after 24 h, and 7, 14, and 21 days.
Results were analyzed by paired Student's t-test. Statistically significant
differences were observed in the 2% chlorhexidine gel group alone or associated
with calcium hydroxide and added of dentin powder (P < 0.05). Mean pH values
indicated the influence of dentin powder because of a significant increase in pH.
Calcium hydroxide with propylene glycol as the vehicle always showed high pH,
demonstrating that this compound was not affected by the presence of dentin.
AN - rayyan-563560645
AU - Freire, L. G.
AU - Carvalho, C. N.
AU - Ferrari, P. H.
AU - Siqueira, E. L.
AU - Gavini, G.
DO - 10.1111/j.1600-9657.2010.00874.x
IS - 3
buffer
calcium hydroxide
chlorhexidine
drug vehicle
gel
propylene glycol
animal
bovine
chemistry
dentin
pH
physiology
time
tooth pulp
LA - English
PY - 2010
SN - 1600-9657
SP - 276-280
ST - Influence of dentin on pH of 2% chlorhexidine gel and calcium hydroxide alone
or in combination
T2 - Dent Traumatol
TI - Influence of dentin on pH of 2% chlorhexidine gel and calcium hydroxide alone
or in combination
VL - 26
ID - 14019
ER -
TY - JOUR
AB - OBJECTIVES: This systematic review was carried out to identify which
naturally-occurring agents and constituents isolated therefrom have effects in
preventing bone loss in a ligature-induced periodontitis model. MATERIALS AND
METHODS: Eight databases were systematically searched for studies of experimental
periodontitis. The data were extracted, analyzed, and the treatment outcomes were
given scores based on the level of bone destruction as compared to their untreated
induced-periodontitis control. RESULTS: 294 articles were found, of which 15 met
the inclusion criteria. The selected studies tested a multi-herbal formulation;
extracts (leaves, barks or fruit) of different plant species; and propolis. The
most usual dosing protocol consisted of 3-times-a-day, 11-day treatment. The
combined gel of Myracrodruon urundeuva (5%) and Lippia sidoides (0.5%) was the most
active treatment, reducing 45-65% bone loss in the region of molars as compared to
73.4% of doxycycline (gold-standard). Ginkgo biloba extract (28-56 mg/kg) and
propolis (100-200 mg/kg) prevented bone destruction by 50% and 40-44%,
respectively. The other tested samples showed intermediate/weak activity in
modulating bone resorption. CONCLUSIONS: The gel of M. urundeuva and L. sidoides,
and G. biloba and propolis extracts showed strong alveolar bone protective
effectiveness in induced-periodontitis in rats. Further translational research
should bridge the gap between the rat study outcomes and the clinical efficacy and
long-term toxicity of these formulations in humans. The compilation of the vast
literature database presented herein may drive further in vivo and clinical studies
with the selected efficacious formulations to subsidize their pharmaceutical
application.
AN - rayyan-563560263
AU - Freires, I. A.
AU - Santaella, G. M.
AU - de Cássia Orlandi Sardi, J.
AU - Rosalen, P. L.
DO - 10.1016/j.archoralbio.2017.12.019
KW - biological product
Ginkgo biloba extract
plant extract
propolis
alveolar bone loss
animal
phytotherapy
procedures
LA - English
PY - 2018
SN - 1879-1506
SP - 196-203
ST - The alveolar bone protective effects of natural products: A systematic review
TI - The alveolar bone protective effects of natural products: A systematic review
VL - 87
ID - 13637
ER -
TY - JOUR
AB - With the goal to establish new tissue regenerative therapy for extensive
regeneration of destroyed periodontal tissues accompanying vertical or horizontal
bone defects due to severe periodontitis, the aim of this study was to evaluate the
kinetics of bone marrow-derived mesenchymal stem cells cultured in a FGF-collagen
complex as a regenerative scaffold in vitro. A mouse bone marrow cell culture kit
was used. The cells (6.0×104 cells/mL) were seeded into the collagen gel culture in
a 24-well plate. After confirming collagen gel formation, 0.5 mL of growth medium
containing the specified concentration of FGF was added gently. The plate was
incubated in 5% CO2 at 37 °C for up to 21 days. The culture medium supplemented
with 10-7 M dexamethasone and 10 mM β glycerol phosphate was used as the growth
medium (0-7 days). The above growth medium with the addition of ascorbic acid (50
μg/mL) was used as the differentiation medium (7-21 days). FGF was added to culture
medium to obtain finally concentrations of 1, 10 and 100 ng/mL. Quantitative
measurements of Calcium and DNA concentrations and ALP activity were performed
using a commercial kit. Morphological changes of cells were observed under the
contact phase microscope. Bone marrow-derived mesenchymal stem cells showed good
growth in the collagen gel culture. The effect of FGF in promoting cell growth is
exhibited at the early stage of culture, and the ALP activity has already passed
the peak when assayed at 21 days of culture at FGF concentrations of 10 ng and 100
ng. The ALP activity decreased in the presence of FGF in a dose-dependent manner at
21 days of culture. A marked difference in calcium content was not observed. The
present study sheds light on the development of an optimal biomaterial that forms
the basis of calcified hard tissue formation, suggesting the feasibility of
applying the 3-D collagen gel cell culture system for the construction of a
scaffold that controls the amount of regenerating tissue.
AN - rayyan-563560594
AU - Fujii, T.
AU - Saito, T.
AU - Yamaguchi, A.
AU - Shimizu, K.
AU - Taira, T.
DO - 10.1016/j.bone.2011.03.228
KW - mineral
collagen gel
calcium
DNA
dexamethasone
glycerophosphate
ascorbic acid
biomaterial
collagen
tissues
bone marrow
society
therapy
bone
culture medium
cell culture
microscope
cell growth
mouse
in vitro study
bone marrow cell
regeneration
bone defect
kinetics
periodontitis
LA - English
PY - 2011
SN - 8756-3282
SP - S122
ST - Study on novel tissue regenerative therapy using bone marrow-derived
mesenchymal stem cells and FGF/collagen complex
T2 - Bone
TI - Study on novel tissue regenerative therapy using bone marrow-derived
mesenchymal stem cells and FGF/collagen complex
VL - 48
ID - 13968
ER -
TY - JOUR
AB - Introduction: Gram-negative Aggregatibacter actinomycetemcomitans is
recognized as an important periodontal pathogen. A striking property of this
bacterium is its ability to form a tenacious biofilm adhering to abiotic surfaces.
Both fimbrial and non-fimbrial adhesins are believed to be responsible for this
ability. In our study, specific markerless mutants in the biosynthesis genes of
cell surface polysaccharides were constructed with the Cre-loxP recombination
system to identify non-fimbrial adhesin(s). Methods: Non-fimbriated A.
actinomycetemcomitans strain ATCC29523 (serotype a) was used to construct a
deletion mutant of serotype-a specific polysaccharide antigen (SPA-a) in
lipopolysaccharide (LPS). The LPS was purified through a polymyxin B column
following phenol extraction, and verified by silver staining following sodium
dodecyl sulfate-polyacrylamide gel electrophoresis and by immunoblot analysis using
rabbit antisera raised against SPA-a. Strains were grown in broth for 2 days and
examined for the adherence of bacterial cells on the glass surface. Results: Strain
ATCC29523 formed a thin film of bacterial growth on the glass surface. The deletion
of SPA-a affected its ability to form this thin film. When this mutant was rescued
with the wild-type SPA-a gene cluster, its adherence-positive phenotype was
restored. Conclusion: SPA-a in the LPS molecule appears to promote the adherence of
A. actinomycetemcomitans cells to abiotic surfaces. © 2008 The Authors.
AN - rayyan-563560700
AU - Fujise, O.
AU - Wang, Y.
AU - Chen, W.
AU - Chen, C.
DO - 10.1111/j.1399-302X.2007.00416.x
IS - 3
KW - adhesin
lipopolysaccharide
polymyxin B
article
bacterium adherence
biofilm
deletion mutant
extraction
fimbria
gene cluster
periodontal disease
plasmid
serotype
Western blotting
LA - English
PY - 2008
SN - ["0902-0055", "1399-302X"]
SP - 226-233
ST - Adherence of Aggregatibacter actinomycetemcomitans via serotype-specific
polysaccharide antigens in lipopolysaccharides
TI - Adherence of Aggregatibacter actinomycetemcomitans via serotype-specific
polysaccharide antigens in lipopolysaccharides
VL - 23
ID - 14074
ER -
TY - JOUR
AN - rayyan-563561925
AU - Fukui, T.
AU - Masuno, K.
AU - Makita, Y.
AU - Fujiwara, S. I.
AU - Shiota, G.
AU - Imamura, Y.
AU - Shiba, A.
AU - Wang, P. L.
DO - 10.2485/jhtb.23.445
IS - 4
PY - 2014
SP - 445-448
ST - Antimicrobial effects of ozone gel against periodontal bacteria
T2 - Journal of Hard Tissue Biology
TI - Antimicrobial effects of ozone gel against periodontal bacteria
84908150885&doi=10.2485%2fjhtb.23.445&partnerID=40&md5=730a39135d3f9bd846a1af031676
0e9b
VL - 23
ID - 15299
ER -
TY - JOUR
AN - rayyan-563561861
AU - Fukui, T.
AU - Masuno, K.
AU - Makita, Y.
AU - Fujiwara, S. I.
AU - Shiota, G.
AU - Imamura, Y.
AU - Shiba, A.
AU - Wang, P. L.
DO - 10.2485/jhtb.24.104
IS - 1
PY - 2015
SP - 104-106
ST - Evaluation of oral mucosa irritation produced by ozone gel
T2 - Journal of Hard Tissue Biology
TI - Evaluation of oral mucosa irritation produced by ozone gel
84921652446&doi=10.2485%2fjhtb.24.104&partnerID=40&md5=d64ff2876a68d56c31291848a99b
b2b5
VL - 24
ID - 15235
ER -
TY - JOUR
AB - The bactericidal potency of ozone was examined for exploring the potential of
dental application of ozone gel. Treatment with 10 ppm ozone gel with quenching
after 3 h and treatment with 100-ppm ozone gel with immediate quenching showed
antimicrobial effects in eight aerobic strains, namely, Escherichia coli,
Pseudomonas aeruginosa, Staphylococcus aureus, Candidaalbicans, Methicillin-
resistant S. aureus (MRSA), S. epidermidis, Klebsiella pneumoniae, and
Streptococcus mutans. For five of these strains (E. coli,P aeruginosa, C. albicans,
K. pneumoniae, and S. mu tans), the number of colony forming units (CFUs) were
below the detection limit after treatment with 10 ppm ozone gel with quenching
after 3 h. For Bacillus subtilis, an antimicrobial effect was observed after 3 h of
treatment with 100 ppm of ozone gel. In the case of anaerobic bacteria,
bactericidal effect was observed for five strains, namely, Porphyromonas
gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Aggregatibacter
actinomycetemcomitans, and Eikenella corrodens, by using ozone gel and ozone cream.
Of these, the number of CFUs for three strains (P. gingivalis, P. intermedia, and
F. nucleatum) was below the detection limit. These results suggest that the ozone
gel can be clinically useful in oral surgery for implant treatment because of its
instantaneous antimicrobial effects, and that it can be used against a variety of
bacterial strains.
AN - rayyan-563562032
AU - Fukui, T.
AU - Masuno, K.
AU - Makita, Y.
AU - Fujiwara, S.
AU - Shiota, G.
AU - Imamura, Y.
AU - Shiba, A.
AU - Wang, P. L.
DO - 10.2485/jhtb.23.445
IS - 4
PY - 2014
SN - 1341-7649
SP - 445-448
ST - Antimicrobial Effects of Ozone Gel Against Periodontal Bacteria
T2 - JOURNAL OF HARD TISSUE BIOLOGY
TI - Antimicrobial Effects of Ozone Gel Against Periodontal Bacteria
VL - 23
Y2 - 10
ID - 15406
ER -
TY - JOUR
AB - Ozone is a potent oxidative gas and its bactericidal effect is exploited in
dental practice. However, the half-life of ozone is extremely short, which limits
its ability to exert bactericidal effects on cells. Therefore, we focused on ozone
gel, which is composed of a glycerin solution containing ozone, a recently
developed technology, in vivo. In the course of our study, we evaluated the safety
of ozone gel application to the skin and eye, as well as its effects on hemostasis
and antimicrobial effects. In this study, we found that ozone gel was nontoxic to
the oral mucosa. Our results suggest that ozone gel represents a clinically agent
for periodontal diseases and pen-implant diseases.
AN - rayyan-563562379
AU - Fukui, T.
AU - Masuno, K.
AU - Makita, Y.
AU - Fujiwara, S.
AU - Shiota, G.
AU - Imamura, Y.
AU - Shiba, A.
AU - Wang, P. L.
DO - 10.2485/jhtb.24.104
IS - 1
PY - 2015
SN - 1341-7649
SP - 104-106
ST - Evaluation of Oral Mucosa Irritation produced by Ozone Gel
TI - Evaluation of Oral Mucosa Irritation produced by Ozone Gel
VL - 24
Y2 - 1
ID - 15753
ER -
TY - JOUR
AB - Objectives: To assess the effectiveness of local antibiotic therapy with
sodium piperacillin plus scaling/root-planing (SRP) versus scaling and root-planing
with local application of chlorhexidine for treating periodontal pockets in
selected patients with chronic generalized periodontitis. Materials and methods: We
conducted an experimental split-mouth study of 20 patients with chronic generalized
periodontitis (probing pocket depth [PPD] ≥5 mm). Each oral cavity was divided into
two sectors: the first was treated with SRP plus local application of sodium
piperacillin and the second with SRP plus local application of chlorhexidine gel.
The PPD and bleeding on probing (BOP) indexes were checked at baseline (time 0) and
1, 3, and 6 months after treatment, and the data obtained were subjected to
statistical analysis. Results: Analysis of PPD and BOP indexes recorded before,
during, and after treatment revealed no statistically significant differences
between the two therapeutic approaches tested (SRP + sodium piperacillin vs SRP +
chlorhexidine). Conclusions: Within the limits of this study, sodium piperacillin
and chlorhexidine appear to be equally effective for use during SRP for the
treatment of moderate-severe chronic generalized periodontitis. © 2011 Elsevier
Srl. All rights reserved.
AN - rayyan-563560592
AU - Fulvi, L.
AU - Polizzi, E.
AU - Calderini, A.
DO - 10.1016/j.pad.2010.12.002
IS - 2
KW - chlorhexidine
piperacillin
sodium piperacillin
unclassified drug
antibiotic therapy
article
bleeding
chronic disease
clinical article
disease severity
drug efficacy
human
mouth cavity
patient selection
periodontal pocket
periodontitis
LA - Italian
PY - 2011
SN - ["0393-9960", "0393-9960"]
SP - 33-43
ST - Effectiveness of local antibiotic therapy plus scaling/root-planing: An
experimental split-mouth study
T2 - Efficacia dell'antibiotico-terapia locale in aggiunta alla terapia meccanica
non chirurgica parodontale: Studio sperimentale split-mouth
TI - Effectiveness of local antibiotic therapy plus scaling/root-planing: An
experimental split-mouth study
VL - 37
ID - 13966
ER -
TY - JOUR
AB - Ethnopharmacological relevance: The presence of biofilm in oral cavity is
associated with dental plaque and related diseases, including gingivitis,
periodontitis and inflammatory responses. Some medicinal plants traditionally used
for biofilm-associated pathologies such as Camellia sinensis (L.) Kuntze, Punica
granatum L. and Lippia sidoides Cham. are currently incorporated into dosage forms
as antiplaque agents. Aims of the study: To present the current application of
medicinal plant extracts associated in drug dosages to control microbial biofilms,
with emphasis on those present in the oral cavity, especially to treat dental
plaque. Materials and methods: A PRISMA-compliant systematic search was conducted
using the PubMed, Web of Science and Scopus databases. After the abstract and full-
text analysis, the Cochrane Collaboration's tools for clinical studies was applied
to assess the methodological quality of randomized clinical trials. Results: Of 964
potentially eligible studies, 47 studies met the inclusion criteria and were
included in the systematic review. Camellia sinensis was the most commonly used
species (8 studies), with positive results in reducing both the PI and GI in the
form of mouthwash, toothpaste and gel. The Melaleuca alternifolia oil (5 studies)
demonstrated low reduction in PI but important effects on GI scores. Azadirachta
indica (4 studies) extracts presented efficacy similar to CHX to improve the
periodontal parameters, including PI and GI. Ricinus communis oil (3 studies),
despite reducing microbiological counts and GI, did not prove to be better than the
hypochlorite solution, used as an alternative treatment for dentures. The main
bioactive compounds described for the plant species are polyphenols, essential oils
and alkaloids, most of them with identified antibiofilm activities. Conclusions:
These active species could lead to future development of safer and newer treatments
for oral biofilm-associated infections. However, more studies are needed to further
understand the clinical relevance of their application.
AN - rayyan-563559929
AU - Furquim dos Santos Cardoso, V.
AU - Amaral Roppa, R. H.
AU - Antunes, C.
AU - Silva Moraes, A. N.
AU - Santi, L.
AU - Konrath, E. L.
DO - 10.1016/j.jep.2021.114541
KW - complete denture
denture
Acacia arabica extract
Acacia catechu extract
alkaloid
Aloe vera extract
anacardic acid
antibiotic agent
Azadirachta indica extract
Barleria prionitis extract
castor oil
chemokine
chlorhexidine
cytokine
distilled water
Embelia ribes extract
Emblica officinalis extract
essential oil
Eugenia uniflora extract
flower extract
fluoride
Garcinia mangostana extract
gel
guava extract
hexigel
Humulus lupulus extract
hypochlorite
hypochlorite sodium
Ilex rotunda extract
kuntze leaves extract
listerine
Magnolia officinalis extract
Matricaria chamomilla extract
Mesua ferrea extract
mouthwash
Ocimum gratissimum extract
Ocimum sanctum extract
oil
ornidazole
placebo
plant extract
polyphenol
pomegranate extract
Quercus infectoria extract
Ricinus communis extract
Rosmarinus officinalis extract
Salvadora persica extract
Senegalia catechu extract
sinecatechins
sodium chloride
sugar
tannin
tea tree oil
Terminalia bellirica extracy
Terminalia chebula extract
Teucrium polium extract
Thymus vulgaris extract
toothpaste
triclosan
unclassified drug
Vitex negundo extract
Wilson cortex extract
Wmbelia ribes extract
xylitol
Acacia arabica
Aloe vera
Azadirachta indica
bark
Barleria prionitis
biofilm
bitter taste
burning sensation
Camellia sinensis
cashew nut
chewing gum
clinical assessment
clinical evaluation
controlled clinical trial (topic)
controlled study
Cymbopogon flexuosus
diarrhea
dizziness
drug dosage form
drug efficacy
Embelia ribes
Eucalyptus globulus
Eugenia uniflora
flower
fruit
Garcinia mangostana
germander
gingiva bleeding
gingival index
gingivitis
guava
human
Ilex rotunda
Leptospermum scoparium
lipedema
Lippia
Lippia sidoides
Magnolia officinalis
medicinal plant
Melaleuca
Melaleuca alternifolia
Mesua ferrea
mouth cavity
mouth disease
mouth flora
oak
Ocimum gratissimum
Ocimum tenuiflorum
outcome assessment
periodontitis
Phyllanthus emblica
plant leaf
plant root
plant stem
plaque index
plasmacytic gingivostomatitis
pollen allergy
pomegranate
powder
Quercus infectoria
review
Ricinus communis
rosemary
Salvadora persica
Sanguinaria canadensis
Schinus terebinthifolius
Scutellaria baicalensis
Senegalia catechu
statistically significant result
stomatitis
systematic review
taste disorder
Terminalia bellirica
Terminalia chebula
thyme
tincture
tooth plaque
Vitex negundo
sensodyne
LA - English
PY - 2021
SN - ["1872-7573", "0378-8741"]
ST - Efficacy of medicinal plant extracts as dental and periodontal antibiofilm
agents: A systematic review of randomized clinical trials
TI - Efficacy of medicinal plant extracts as dental and periodontal antibiofilm
agents: A systematic review of randomized clinical trials
VL - 281
ID - 13303
ER -
TY - JOUR
AB - Background: Propolis is a resinous complex produced by Apis mellifera L. bees
whose variety of pharmacological properties results from the complexity of its
composition. In dentistry, propolis is used on the prevention of oral diseases such
as dental caries and gingivitis. Prospective studies in intellectual property banks
are important to increase market competitiveness and thus generate new products in
the various research areas. In this way, investments in patents play an important
role in the technological and economic development of a country. Objective: To
evaluate patents with dental products containing propolis, on intellectual property
banks. Method: The research was conducted in 10 banks of intellectual property,
including since the first deposits up to 2016. Relevant information that describes
the invention in the patent document were collected, processed and described.
Results: The search performed in 62 patents using propolis in the dental topic.
World Intellectual Property Organization (WIPO) has the largest number of filing
patents (83.60%) and the National Institute of Industrial Property (INPI) in third
place with 4 patents (6.55%). Built-in dental cream with propolis was the most
patented product. The first patent date of 1998, followed by an increase in the
number of deposits in the last 20 years. Most of the patents are A61K code (51) for
medical, dental or hygienic purposes. Conclusion: This study has shown that
propolis is a promising bioactive component in dental products, especially for use
in Cariology and Periodontology. Although there has been a significant progress in
applications of propolis, the field of dental products is still a growing area and
it is important to encourage innovation and development of new products
incorporating propolis based on knowledge of its composition and therapeutic
properties.
AN - rayyan-563560269
AU - Furtado, J. H. C.
AU - Valadas, L. A. R.
AU - Mendonça, K. S.
AU - Filho, R. D. O.
AU - Gadelha, L. M. U.
AU - Fiallos, N. M.
AU - Neto, E. M. R.
AU - Fiallos, A. C. M.
AU - Fonteles, M. M. F.
DO - 10.2174/2211550107666180815114855
IS - 4
KW - mouthwash
natural product
propolis
article
decision making
dental caries
dental procedure
dentistry
developing country
economic development
gel
gingivitis
human
mouth hygiene
patent
periodontics
practice guideline
priority journal
tincture
varnish
LA - English
PY - 2018
SN - 1872-2083
SP - 288-296
ST - Propolis and its dental applications: A technological prospection
T2 - Recent Pat. Biotechnol.
TI - Propolis and its dental applications: A technological prospection
VL - 12
ID - 13643
ER -
TY - JOUR
AB - The present clinical trial was performed to evaluate short-term effects of a
triclosan-containing dentifrice/gel combination on soft tissue healing, when
applied supra-/sub-gingivally at periodontal sites treated with scaling and root
planing. 16 subjects with moderate periodontitis participated in a 2x 2-week,
split-mouth designed clinical trial. 2 combinations of gel/dentifrice (the test
combination containing triclosan) were used. 2 pairs of contralateral sites with
probing pocket depth (PPD) > or 5 mm, and which bled on probing (BoP +) were
selected in each patient as experimental units. A baseline examination included
assessments of PPD, BoP, gingival index scores, plaque index scores, and the
composition of the subgingival microbiota (dark-field microscopy). The assigned
quadrant was anaesthetized and the teeth exposed to meticulous scaling and root
planing. Immediately after the completion of mechanical therapy, either the test or
control gel was applied subgingivally at the experimental sites. The volunteer was
instructed to brush his/her teeth with an assigned dentifrice and to apply the gel
(via a custom-made stent) supra-gingivally 2x daily for the following 2 weeks.
He/she was recalled on day 7 for a second professional subgingival gel application.
Re-examinations were carried out on days 2, 7 and 14 after treatment. 1-week wash-
out periods separated the 2 experimental periods. The mean PPD reductions (between
days 0 and 14) were 1.8 mm and 1.9 mm for the test and control gel/dentifrice
sites. The reduction in BoP and gingival index scores was significantly greater
during the test than during the control regimen. No significant differences were
observed between the 2 regimens regarding plaque scores and composition of the
subgingival microbiota. The findings from the present investigation demonstrated
that triclosan, applied both sub- and supra-gingivally reduced soft tissue
inflammation following scaling and root planing.
AN - rayyan-563561037
AU - Furuichi, Y.
AU - Ramberg, P.
AU - Krok, L.
AU - Lindhe, J.
IS - 10
KW - dodecyl sulfate sodium
placebo
polyvinylmethoxyethylene maleic anhydride copolymer
polyvinylmethoxyethylene-maleic anhydride copolymer
surfactant
toothpaste
triclosan
article
bacterium
clinical trial
controlled study
drug effect
evaluation study
female
follow up
gel
gingiva
gingiva bleeding
gingivitis
human
male
microbiology
middle aged
pathology
periodontics
periodontitis
tooth plaque
wound healing
LA - English
PY - 1997
SN - 0303-6979
SP - 777-782
ST - Short-term effects of triclosan on healing following subgingival scaling
TI - Short-term effects of triclosan on healing following subgingival scaling
VL - 24
ID - 14411
ER -
TY - JOUR
AB - Local delivery of antibiotics has been shown to be effective in reducing
periodontopathic microorganisms. The purpose of this study is to formulate gels
containing secnidazole or doxycycline hydrochloride that could be used in the
treatment of periodontitis by direct periodontal intrapocket administration.
Different mucoadhesive polymers were used as cellulose derivatives, carbopol and
eudragit. The prepared gels were evaluated for their in vitro drug release,
rheological behavior, and mucoadhesive force. Increasing the concentration of each
polymer increased the viscosity, mucoadhesion, and the time required for 30 and 50%
release of the original mass of each drug. Gels with appropriate balance of the
above-examined parameters were selected for microbiological evaluation.
Microbiological studies on selected gels showed faster release of the two drugs
(expressed as inhibition zones) than the commercial products of chlorhexidine gel
(Elugel®) and miconazole nitrate emulgel (Miconaz®). Copyright © Informa UK, Ltd.
AN - rayyan-563560690
AU - Gad, H. A.
AU - El-Nabarawi, M. A.
AU - Abd El-Hady, S. S.
DO - 10.1080/03639040802122944
IS - 12
KW - carbomer
chlorhexidine
doxycycline
elugel
eudragit
miconaz
miconazole
secnidazole
unclassified drug
article
bacterium isolate
drug formulation
drug release
flow kinetics
gel
human
mucoadhesion
nonhuman
periodontitis
LA - English
PY - 2008
SN - ["0363-9045", "1520-5762"]
SP - 1356-1367
ST - Formulation and evaluation of secnidazole or doxycycline dento-oral gels
TI - Formulation and evaluation of secnidazole or doxycycline dento-oral gels
VL - 34
ID - 14064
ER -
TY - JOUR
AB - Local delivery of antibiotics has been shown to be effective in reducing
periodontopathic microorganisms. The purpose of this study is to formulate gels
containing secnidazole or doxycycline hydrochloride that could be used in the
treatment of periodontitis by direct periodontal intrapocket administration.
Different mucoadhesive polymers were used as cellulose derivatives, carbopol and
eudragit. The prepared gels were evaluated for their in vitro drug release,
rheological behavior, and mucoadhesive force. Increasing the concentration of each
polymer increased the viscosity, mucoadhesion, and the time required for 30 and 50%
release of the original mass of each drug. Gels with appropriate balance of the
above-examined parameters were selected for microbiological evaluation.
Microbiological studies on selected gels showed faster release of the two drugs
(expressed as inhibition zones) than the commercial products of chlorhexidine gel
(Elugel) and miconazole nitrate emulgel (Miconaz).
AN - rayyan-563562325
AU - Gad, H. A.
AU - El-Nabarawi, M. A.
AU - El-Hady, S. S.
DO - 10.1080/03639040802122944
IS - 12
PY - 2008
SN - ["0363-9045", "1520-5762"]
SP - 1356-1367
ST - Formulation and Evaluation of Secnidazole or Doxycycline Dento-Oral Gels
T2 - DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
TI - Formulation and Evaluation of Secnidazole or Doxycycline Dento-Oral Gels
VL - 34
ID - 15699
ER -
TY - JOUR
AB - Objective: To formulate solid lipid microparticles (SLMs) encapsulating
doxycycline hydrochloride (DH) and metronidazole (MT) for the treatment of
periodontal diseases. Methods: SLMs were prepared applying hot homogenization
method, using different types of lipids and stabilized with various types and
concentrations of surfactants. The optimized formula was subjected to freeze-drying
followed by incorporation into poloxamer gel. Microbiological and clinical
evaluation of the selected SLMs on patients suffering from periodontal diseases was
performed. Results: SLMs could entrap high percentage of both drugs (81.14% and
68.75 % for doxycycline hydrochloride and metronidazole respectively). Transmission
electron microscopy images of SLMs showed nearly spherical particles. Freeze-dried
SLMs showed satisfactory stability for three months. Combined drugs were
molecularly dispersed in SLMs. Incorporation of the freeze-dried SLMs powder in
poloxamer gel could control the drugs release for 72 h. In-vivo study revealed
effective and safe use of SLMs gel for periodontitis treatment. Significant
improvement in both microbiological and clinical parameters was observed as
compared to scaling and root planing alone. Conclusion: The formulated SLMs gel
offers an applicable dosage form that can be injected directly into the periodontal
pocket as adjunctive to scaling and root planing.
AN - rayyan-563560282
AU - Gad, H. A.
AU - Kamel, A. O.
AU - Ezzat, O. M.
AU - El Dessouky, H. F.
AU - Sammour, O. A.
DO - 10.1080/17425247.2017.1329297
IS - 11
KW - doxycycline
metronidazole
poloxamer
adult
article
bacterial count
bacterial growth
bitter taste
clinical article
clinical trial
dental scaling
dispersion
drug formulation
drug release
drug stability
female
freeze drying
gel
gingival index
gingivitis
human
in vitro study
in vivo study
inflammation
male
microencapsulation
outcome assessment
particle size
periodontal pocket
plaque index
root planing
side effect
solid lipid microparticle gel
tooth plaque
zeta potential
LA - English
PY - 2017
SN - ["1744-7593", "1742-5247"]
SP - 1241-1251
ST - Doxycycline hydrochloride-metronidazole solid lipid microparticles gels for
treatment of periodontitis: development, in-vitro and in-vivo clinical evaluation
T2 - Expert Opin. Drug Deliv.
TI - Doxycycline hydrochloride-metronidazole solid lipid microparticles gels for
treatment of periodontitis: development, in-vitro and in-vivo clinical evaluation
VL - 14
ID - 13656
ER -
TY - JOUR
AB - New approaches to treating periodontal diseases aim to balance sustaining the
natural oral microbiota and modifying the host immune response. Gum Arabic (GA) is
a natural polysac-charide rich in prebiotics.The aim of this study was to assess
the effect of GA on clinical (Plaque Index (PI), Gingival Index (GI)) and
immunological (Gingival Crevicular Fluid Interleukin 1 Beta (GCF IL-1 b))
parameters in patients with plaque-induced gingivitis.Materials and methods: This
placebo-controlled, double-blinded randomised clinical trial was conducted at the
Department of Periodontology at Khartoum Dental Teaching Hospital, Khar-toum,
Sudan, from July to October 2016. Patients diagnosed with plaque-induced gingivitis
meeting the study eligibility criteria were enrolled. At baseline, PI, GI and GCF
IL-1b were measured. Patients received full-mouth scaling and were randomly
assigned to receive either GA powder (in-tervention group) or Microcrystalline
cellulose powder (placebo group). The patients were instructed to apply the
treatment twice a day throughout the study. The PI, GI and GCF IL-1b were
reassessed after 30 and 60 days.Results: A total of 60 patients were enrolled (30
in each group). Compared to the placebo group, the intervention group showed a
statistically significant reduction in GI scores after 30 days and improved PI
scores at 30 and 60 days. Between baseline and 60 days, patients who received GA
exhibited a significant reduction in GCF IL-1b levels compared to the placebo
group.Conclusion: GA was found to be effective in controlling plaque and
gingivitis.Clinical Trial Registration. ISRCTN registry ISRCTN14209449.(c) 2022 The
Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.
This is an open access article under the CC BY-NC-ND license
AN - rayyan-563562598
AU - Gafar, A. M.
AU - Ramadan, A. M.
AU - ElSaid, N. A.
AU - Nurelhuda, N. M.
DO - 10.1016/j.sdentj.2022.06.002
IS - 6
PY - 2022
SN - ["1013-9052", "1658-3558"]
SP - 494-502
ST - Effect of Gum Arabic on plaque-induced gingivitis: A randomised controlled
trial
T2 - SAUDI DENTAL JOURNAL
TI - Effect of Gum Arabic on plaque-induced gingivitis: A randomised controlled
trial
VL - 34
Y2 - 9
ID - 15972
ER -
TY - JOUR
AB - This presentation provides an overview of the technologies available for the
chemical control of plaque. It is generally accepted that the formation of dental
plaque at the interfaces of tooth/gingiva is one of the major causes of gingival
inflammation and dental caries. Several therapeutic approaches have been used to
control dental plaque and supragingival infections. These include fluoride
preparations such as stannous fluoride, oxygenating agents, anti-attachment agents,
and cationic and non-cationic antibacterial agents. Among the fluoride
preparations, stable stannous fluoride pastes and gels have been shown to reduce
supragingival plaque, gingivitis, hypersensitivity and caries. The effect of the
oxygenating agents on the supragingival plaque has been equivocal, but recent data
indicate that a stable agent which provides sustained active oxygen release is
effective in controlling plaque. A polymer, PVPA, which reduced attachment of
bacteria to teeth was shown to significantly reduce plaque formation in humans. A
new generation of antibacterials includes non-ionics such as triclosan, which in
combination with a special polymer delivery system, has been shown to reduce
plaque, gingivitis, supragingival calculus and dental caries in long-term studies
conducted around the world. Unlike the first generation of agents, the
triclosan/copolymer/sodium fluoride system is effective in long-term clinicals and
does not cause staining of teeth, increase in calculus, or disturbance in the oral
microbial ecology.
AN - rayyan-563561038
AU - Gaffar, A.
AU - Afflitto, J.
AU - Nabi, N.
IS - 5
cation
sodium fluoride
oxidizing agent
phosphonic acid derivative
tin fluoride
toothpaste
triclosan
bacterium
bacterium adherence
chemoprophylaxis
dental caries
drug effect
gel
gingiva
gingivitis
human
longitudinal study
microbiology
review
tooth
tooth calculus
tooth discoloration
tooth plaque
LA - English
PY - 1997
SN - 0909-8836
SP - 502-507
ST - Chemical agents for the control of plaque and plaque microflora: an overview
TI - Chemical agents for the control of plaque and plaque microflora: an overview
VL - 105
ID - 14412
ER -
TY - JOUR
AB - Introduction: Insufficient effectiveness of traditional drug therapy in a
treatment of patients with chronic generalized periodontitis, as well as high
social significance of this problem, determines the need to search for new drugs
and their compositions aimed at solving it. Aim of the study: To increase the
efficacy of complex treatment of periodontitis with the administration of Soderm®-
Forte gel and a new injectable form of Rexod®. Materials and methods: Experiments
were performed in 50 male Wistar rats. Experimental periodontitis (EP) was
simulated by ligation of the necks of lower incisors. We studied the animals with
intact periodontium, untreated EP, and when traditional drug therapy (TDT), as well
as the combinations of TDT with Soderm®-Forte gel and additionally with the new
injectable dosage form (NIF) of Rexod® were administered. The general condition,
behavior, nutrition and body weight of the animals were evaluated. The Schiller-
Pisarev test and the Muhlemann-Cowell bleeding index were used, and the amount of
crevicular fluid (CF) was measured. The contamination of the marginal gum with
microorganisms was determined. Results and discussion: The TDT in EP has a moderate
therapeutic effect, which does not lead to a sufficiently high pharmacotherapeutic
effect, whereas the combinations of TDT with Soderm®-Forte and, to a greater
extent, TDT with Soderm®-Forte and NIF of Rexod® have high therapeutic efficacy,
which is statistically confirmed by a sharp decrease in the amount of CF, the
Schiller-Pisarev test and the Muhlemann-Cowell bleeding index, as well as absolute
suppression of pathogenic microorganisms. Conclusion: The combinations of TDT with
Soderm®-Forte gel and NIF of Rexod® in EP in rats can significantly increase the
effectiveness of the treatment. The data obtained indicate the expediency of the
administration of Soderm®-Forte gel, as well as its combination with NIF of Rexod®
in dental practice in the complex therapy of patients with periodontitis.
AN - rayyan-563559918
AU - Galenko-Yaroshevsky, P. A.
AU - Tseluiko, K. V.
AU - Leontev, V. K.
AU - Zadorozhniy, M. A.
AU - Popkov, V. L.
AU - Zelenskaya, A. V.
AU - Babichev, S. A.
AU - Zadorozhniy, A. V.
AU - Meladze, S. V.
DO - 10.3897/rrpharmacology.8.79641
IS - 1
KW - suture
dermatological agent
gel
rexod
soderm
tiletamine plus zolazepam
unclassified drug
animal experiment
animal model
article
behavior assessment
bleeding
body weight
contamination
controlled study
drug efficacy
general condition
gingivitis
incisor
ligation
male
nonhuman
nutritional assessment
rat
therapy effect
zoletil
LA - English
PY - 2022
SN - 2658-381X
SP - 51-58
ST - The effectiveness of Soderm® - forte gel and a new injectable dosage form of
Rexod® in the complex treatment of experimental periodontitis in rats
T2 - Res. Results Pharm.
TI - The effectiveness of Soderm® - forte gel and a new injectable dosage form of
Rexod® in the complex treatment of experimental periodontitis in rats
VL - 8
ID - 13292
ER -
TY - JOUR
AB - OBJECTIVES: This double-blind study examined the bleaching effectiveness of
two 30% carbamide peroxide bleaching gels: one with 5% potassium nitrate (treatment
A) and one without (treatment B). The treatment time was reduced for this pilot
study to one hour per day for 10 days to determine whether the higher concentration
would whiten teeth and to ascertain the tooth sensitivity and gingival effects of
the 30% solution. METHOD AND MATERIALS: Forty subjects were selected with an
initial tooth shade corresponding to Bioform shade guide B65 or darker. After
obtaining consent, subjects were randomly divided into two groups (n = 20). Custom-
fabricated bleaching trays were made for each subject. Trays did not extend onto
the gingiva. Each subject was instructed in the placement and wear of the tray and
bleach and supplied with one of the two bleaching gels. Subjects had 10 hours of
treatment time with the bleaching gel. Photographs and shades (using a standardized
Bioform shade guide) were taken at baseline and at final recall to determine
bleaching effectiveness. Tooth sensitivity was measured at baseline and final
recall by applying a pellet saturated with skin refrigerant to the tooth for 2
seconds. The sensitivity was recorded on a scale ranging from 1 to 10. Gingival
index was also measured at baseline and at final recall. Data was analyzed with
Wilcoxon rank-sum and Wilcoxon signed rank tests. RESULTS: No significant
differences were found for changes in color, tooth sensitivity, and gingival
condition between the two bleaching gels (P = .899, P = .375, and P = .056,
respectively). Within each group, bleaching gel A and B significantly whitened
teeth (P < .0001 for both groups). There were no significant changes in tooth
sensitivity and gingival condition for gel A (P = .057 and .063, respectively) or
gel B (P = .911 and .510, respectively). CONCLUSION: Thirty percent carbamide
bleaching gels effectively whiten teeth without causing a significant increase in
tooth sensitivity or changes in gingival condition. Potassium nitrate has little
effect in sensitivity when treatment time is short.
AN - rayyan-563560680
AU - Gallo, J. R.
AU - Burgess, J. O.
AU - Ripps, A. H.
AU - Bell, M. J.
AU - Mercante, D. E.
AU - Davidson, J. M.
IS - 4
nitrate
oxidizing agent
peroxide
potassium derivative
potassium nitrate
urea
carbamide peroxide
article
clinical trial
controlled study
dental procedure
dental device
drug combination
gingivitis
human
methodology
periodontics
pilot study
treatment outcome
LA - English
PY - 2009
SN - 1936-7163
SP - e1-6
ST - Evaluation of 30% carbamide peroxide at-home bleaching gels with and without
potassium nitrate--a pilot study
TI - Evaluation of 30% carbamide peroxide at-home bleaching gels with and without
potassium nitrate--a pilot study
VL - 40
ID - 14054
ER -
TY - JOUR
AB - Composite resins are commonly used in dentistry for direct restorations. The
color stability of these materials still represents a major concern for both the
clinician and the patient. In recent years, ozone therapy has been extensively used
in dentistry to manage wounds healing, dental caries, oral lichen planus,
gingivitis and periodontitis, halitosis, osteonecrosis of the jaw, post-surgical
pain, plaque and biofilms, root canal treatment, dentin hypersensitivity,
temporomandibular joint disorders, and teeth whitening. To date, several studies
have evaluated the bleaching effect exerted by ozone on natural teeth, but no
studies have been conducted to determine the effect on the color of composite
resins. The aim of the present study is to determine whether ozonized oils/gels
could determine a color change on composite resin. A total of 40 discs of an A3
shade restorative composite were divided into two groups, respectively exposed to a
pigmentation treatment consisting of 10 applications of 10 min each of a 1%
chlorhexidine-based gel (trial group) and to storage into physiological solution
(control group). The samples of both groups were respectively subdivided into four
subgroups which underwent four different protocols, three of which were based on
the exposure to different ozonized products and the latter representing the
control. A colorimetric analysis with the CIELAB method was conducted with the
following timing: after 24 h of storage in physiological solution (before the
experimental procedures) (T0), after the subdivision into groups A and B
(corresponding to the pigmentation for samples of group A and storage in
physiological solution for samples of group B) (T1), and after subdivision into
subgroups 1-4 (corresponding to the application of the ozonized products vs.
control) (T2). No statistically significant difference was found between the
samples at T0. The 20 samples of group A, exposed to the colorant agent, underwent
a color change from T0 to T1, whereas the 20 samples exposed to the physiologic
solution did not undergo any significant color change. A positive but moderate
influence was assessed for E and L values, whereas no significant change occurred
for A and B values. Therefore, dental ozonized oils/gels could be valuable in
restorative dentistry as bleaching agents of resin composites exposed to
discoloration, an alternative to the traditional hydrogen peroxide and carbamide
peroxide, but further studies are required to confirm these findings.
AN - rayyan-563562616
AU - Gallo, S.
AU - Colombo, M.
AU - Poggio, C.
AU - Scribante, A.
AU - Saracino, M.
AU - Beltrami, R.
DO - 10.3390/app13042149
IS - 4
PY - 2023
SN - 2076-3417
ST - Bleaching Effect of Ozonized Substances on Resin Composite: A New
Potentiality for Ozone Therapy in Dentistry
TI - Bleaching Effect of Ozonized Substances on Resin Composite: A New
Potentiality for Ozone Therapy in Dentistry
VL - 13
Y2 - 2
ID - 15990
ER -
TY - JOUR
AB - This study evaluated the incidence of postoperative pain after intracanal
dressings with either 0.12% chlorhexidine digluconate gel (CHX) or a calcium
hydroxide/camphorated paramonochlorophenol/glycerin paste (CH/CPMC). Overall, 138
asymptomatic teeth had their canals instrumented under irrigation with 2.5% NaOCl
and then dressed with either CH/CPMC or CHX. The incidence of different intensity
levels of postoperative pain was registered for the period between appointments.
Data revealed that 84% of the total number of cases treated with either medicament
showed absence of any level of pain. No case medicated with CH/CPMC and four cases
(5.8%) medicated with CHX were categorized as flare-ups. There were no
statistically significant differences between all possible comparisons involving
the two medicaments in treatment/retreatment cases and teeth with/without apical
periodontitis lesions. The low incidence of postoperative pain after the use of
both medications, coupled to their antimicrobial effectiveness, gives support to
using one or the other in routine treatment/retreatment.
AN - rayyan-563562583
AU - Gama, T. G. V.
AU - de Oliveira, J. C. M.
AU - Abad, E. C.
AU - Rocas, I. N.
AU - Siqueira, J. F.
DO - 10.1007/s00784-008-0199-3
IS - 4
PY - 2008
SN - 1432-6981
SP - 325-330
ST - Postoperative pain following the use of two different intracanal medications
TI - Postoperative pain following the use of two different intracanal medications
VL - 12
Y2 - 12
ID - 15957
ER -
TY - JOUR
the two medicaments in treatment/ retreatment cases and teeth with/without apical
using one or the other in routine treatment/retreatment. © Springer-Verlag 2008.
AN - rayyan-563560691
AU - Gama, T. G. V.
AU - Machado de Oliveira, J. C.
AU - Abad, E. C.
AU - Rôças, I. N.
AU - Siqueira Jr, J. F.
DO - 10.1007/s00784-008-0199-3
IS - 4
calcium hydroxide
camphor
camphorated parachlorophenol
chlorhexidine
chlorophenol
drug derivative
glycerol
adolescent
adult
aged
article
child
clinical trial
comparative study
controlled study
drug combination
endodontics
human
methodology
middle aged
postoperative pain
retreatment
tooth pain
LA - English
PY - 2008
SN - ["1432-6981", "1436-3771"]
SP - 325-330
T2 - Clin. Oral Invest.
VL - 12
ID - 14065
ER -
TY - COMP
the two medicaments in treatment/retreatment cases and teeth with/without apical
using one or the other in routine treatment/retreatment.
AN - rayyan-563561403
AU - Gama, T. G.
AU - de Oliveira, J. C.
AU - Abad, E. C.
AU - Rôças, I. N.
AU - Siqueira, J. F., Jr.
CY - Germany
DO - 10.1007/s00784-008-0199-3
ET - 4
J2 - Clin Oral Investig
KW - Adolescent
Adult
Aged
Calcium Hydroxide/therapeutic use
Camphor/therapeutic use
Child
Chlorhexidine/analogs & derivatives/therapeutic use
Chlorophenols/therapeutic use
Drug Combinations
Glycerol/therapeutic use
Humans
Middle Aged
Pain, Postoperative/*prevention & control
Periapical Periodontitis/therapy
Retreatment
Root Canal Irrigants/*therapeutic use
Root Canal Preparation/*methods
Toothache/*prevention & control
Young Adult
LA - eng
N1 - Department of Endodontics, Estácio de Sá University, Rio de Janeiro, Rio de
Janeiro, Brazil.
PY - 2008
SP - 325-30
T2 - Clinical oral investigations
VL - 12
Y2 - 12
ID - 14777
ER -
TY - JOUR
AB - Background: The release profile of 25% doxycycline (DOX) gel loaded on a
biodegradable collagen membrane (COL) after 24% EDTA root surface etching was
evaluated. Methods: Thirty systemically healthy patients, each with at least one
pair of contralateral interproximal intrabony defects ≥4 mm deep, along with an
interproximal probing depth ≥6 mm and clinical attachment loss ≥4 mm, were
randomized into two groups. Group 1 consisted of sites treated with open-flap
debridement followed by placement of DOX gel-loaded COL (DOX-COL), whereas group 2
sites were treated with flap surgery followed by the placement of DOX-COL after
EDTA etching of the exposed root surfaces (DOX-COL+ EDTA). Samples of gingival
crevicular fluid were obtained 1, 3, 7, 14, and 21 days after surgery. Separation
was performed, and quantitative measurements of DOX were taken with a high-
performance liquid chromatography. Clinical evaluation and follow-up for 6 months
were performed. Results: At 21 days, DOX-COL + EDTA group showed 5.3 μg/mL value.
However, no DOX was detected in samples of the DOX-COL group. DOX-COL + EDTA-
treated group retained more DOX during the periods of 3, 7, 10, and 14 days than
did the DOX-COL group. Conclusion: EDTA root surface etching could enhance DOX
availability in the gingival crevicular fluid after its release from the collagen
membrane.
AN - rayyan-563560529
AU - Gamal, A. Y.
AU - Kumper, R. M.
DO - 10.1902/jop.2011.110476
IS - 9
chelating agent
collagen
doxycycline
edetic acid
adult
alveolar bone loss
article
artificial membrane
biodegradable implant
chemistry
comparative study
controlled study
dental acid etching
diffusion
drug effect
female
follow up
gel
gingivitis
human
male
methodology
middle aged
periodontal pocket
surgical flaps
tooth root
LA - English
PY - 2012
SN - 0022-3492
SP - 1086-1094
ST - A novel approach to the use of doxycycline-loaded biodegradable membrane and
EDTA root surface etching in chronic periodontitis: A randomized clinical trial
TI - A novel approach to the use of doxycycline-loaded biodegradable membrane and
EDTA root surface etching in chronic periodontitis: A randomized clinical trial
VL - 83
ID - 13903
ER -
TY - JOUR
AB - Background: The main objectiveofthe present study was to quantify
chlorhexidine (CHX) release after the use of CHX-EDTA root surface treatment as a
local-delivery antimicrobial vehicle. Methods: Twentynon-smoking patients
clinically diagnosed as having moderate-to-severe chronic periodontitis were
selected to participate in this study. After cause-related therapy, one site in
every patient received defect overfill with CHX gel 2% (20 sites). In addition,
twenty contralateral sites received defect fill of CHX gel after 3 minutes of 24%
EDTA gel root surface etching (20 sites). Gingival crevicular fluid samples were
collected at 1, 3, 7, and 14 days post-therapy. Results: The CHX-EDTA group showed
statistically significantly higher levels of CHX than those of the control group at
1,3, and 7 days.At 14 days,the CHX-EDTA group showed 0.8 mg/mL values. Conclusion:
The use of CHX-EDTA root surface treatment as a local-delivery antimicrobial
improves CHX substantivity.
AN - rayyan-563560595
AU - Gamal, A. Y.
AU - Kumper, R. M.
AU - Sadek, H. S.
AU - El Destawy, M. T.
DO - 10.1902/jop.2010.100523
IS - 5
chlorhexidine
edetic acid
adult
alveolar bone loss
article
chemistry
clinical trial
comparative study
controlled study
dental acid etching
drug effect
female
follow up
gingivitis
human
male
methodology
middle aged
mouth hygiene
periodontal disease
periodontal pocket
periodontics
tooth plaque
tooth root
LA - English
PY - 2011
SN - 0022-3492
SP - 751-757
ST - Chlorhexidine controlled-release profile after EDTA root surface etching: An
in vivo study
TI - Chlorhexidine controlled-release profile after EDTA root surface etching: An
in vivo study
VL - 82
ID - 13969
ER -
TY - COMP
AB - BACKGROUND: The main objective of the present study was to quantify
chlorhexidine (CHX) release after the use of CHX-EDTA root surface treatment as a
local-delivery antimicrobial vehicle. METHODS: Twenty non-smoking patients
clinically diagnosed as having moderate-to-severe chronic periodontitis were
selected to participate in this study. After cause-related therapy, one site in
every patient received defect overfill with CHX gel 2% (20 sites). In addition,
twenty contralateral sites received defect fill of CHX gel after 3 minutes of 24%
EDTA gel root surface etching (20 sites). Gingival crevicular fluid samples were
collected at 1, 3, 7, and 14 days post-therapy. RESULTS: The CHX-EDTA group showed
statistically significantly higher levels of CHX than those of the control group at
1, 3, and 7 days. At 14 days, the CHX-EDTA group showed 0.8 mg/mL values.
CONCLUSION: The use of CHX-EDTA root surface treatment as a local-delivery
antimicrobial improves CHX substantivity.
AN - rayyan-563561412
AU - Gamal, A. Y.
AU - Kumper, R. M.
AU - Sadek, H. S.
AU - El Destawy, M. T.
CY - United States
DO - 10.1902/jop.2010.100523
ET - 5
J2 - J Periodontol
KW - Acid Etching, Dental/*methods
Adult
Alveolar Bone Loss/drug therapy/therapy
Chelating Agents/*therapeutic use
Chromatography, High Pressure Liquid
Chronic Periodontitis/*drug therapy/therapy
Dental Plaque Index
Dental Scaling
Edetic Acid/*therapeutic use
Female
Follow-Up Studies
Gingival Crevicular Fluid/chemistry
Humans
Male
Middle Aged
Oral Hygiene
Periodontal Attachment Loss/drug therapy/therapy
Periodontal Index
Root Planing
Subgingival Curettage
Tooth Root/*drug effects
LA - eng
N1 - Department of Periodontology, Faculty of Dental Medicine, Al-Azhar
University, Cairo, Egypt. hgamal1@hotmail.com
PY - 2011
SP - 751-7
ST - Chlorhexidine controlled-release profile after EDTA root surface etching: an
in vivo study
TI - Chlorhexidine controlled-release profile after EDTA root surface etching: an
in vivo study
VL - 82
Y2 - 5
ID - 14786
ER -
TY - JOUR
AB - Background: Infection control is an important requirement during the early
stages of periodontal healing. This study was performed to assess the
preconditioning effect of EDTA gel on Chlorhexidine (CHX) substantivity to
periodontally involved root surfaces. Methods: Eighty patients with severe chronic
periodontitis were enrolled in this study. Following cause-related therapy,
patients were divided randomly into four groups. Each group consisted of 20
subjects with one tooth that was diagnosed as hopeless and designated for
extraction. In group 1 (G1), selected periodontal pockets were filled with a
placebo gel in a silica base for 2 minutes. Exposed roots in group 2 (G2) were
etched for 2 minutes with a neutral EDTA conditioning agent, followed by pocket
fill with the placebo gel. Pockets in group 3 (G3) were filled with 0.12% CHX
digluconate gel in a silica base. Exposed roots in group 4 (G4) were etched for 2
minutes with a neutral EDTA conditioning agent, followed by pocket fill with the
CHX gel. Four teeth from each group were extracted immediately and at 3,12,24, and
48 hours for SEM evaluation. Results: G1 and G2 specimens showed no evidence of
silica adherent to any of the examined root surfaces. At 3 hours following CHX gel
application, G3 specimens showed marked reduction in CHX-coated silica. At 24 and
48 hours following EDTA and CHX gel application, G4 specimens demonstrated adherent
CHX-coated silica particles despite the reclogging of the tubule orifices.
Conclusion: EDTA and CHX gel root conditioning is a valuable regimen that improves
CHX substantivity to periodontally involved root surfaces.
AN - rayyan-563560738
AU - Gamal, A. Y.
AU - Mailhot, J. M.
DO - 10.1902/jop.2007.070124
IS - 9
chlorhexidine
edetic acid
silica gel
silicon dioxide
adult
article
chronic disease
clinical trial
controlled study
dental surgery
drug effect
female
human
male
middle aged
periodontitis
surface property
tooth root
ultrastructure
LA - English
PY - 2007
SN - 0022-3492
SP - 1759-1766
ST - Effects of EDTA gel preconditioning of periodontally affected human root
surfaces on chlorhexidine substantivity - An SEM study
TI - Effects of EDTA gel preconditioning of periodontally affected human root
surfaces on chlorhexidine substantivity - An SEM study
VL - 78
ID - 14112
ER -
TY - JOUR
AB - PURPOSE: To evaluate the efficacy and safety of a new 5.9% hydrogen peroxide
liquid, invisible gel, (Colgate Simply-White Whitening Gel). METHODS: A total of 30
subjects were enrolled into the study and divided into two treatment groups
(Colgate vs. placebo gel). Efficacy was assessed using VITA shade scores and safety
evaluations were performed including the examination of plaque index (PI), bleeding
index (BOP), gingival recession and dentin hypersensitivity. Statistical analysis
was performed to determine the mean change from baseline. RESULTS: The new
whitening gel containing 5.9% hydrogen peroxide was significantly effective in
lightening tooth shade. After only 2 weeks, patients enrolled in the study
exhibited an overall mean 4.48-shade improvement from baseline, which was
significantly greater than placebo group and far exceeded the ADA minimum
requirements to claim "clinical efficacy". In the new Colgate Simply White Clear
Whitening Gel group, periodontal health (PI and BOP) improved with time overall.
Moreover, dentin hypersensitivity did not significantly increase, and all
treatments were generally well tolerated. CLINICAL SIGNIFICANCE: The new Colgate
Simply White whitening gel containing 5.9% hydrogen peroxide allowed consistent
bleaching using minimal contact time, without adversely impacting overall
tolerability.
AN - rayyan-563560868
AU - Gambarini, G.
AU - Testarelli, L.
AU - De Luca, M.
AU - Dolci, G.
IS - 2
KW - Colgate Simply White Clear Whitening Gel
hydrogen peroxide
oxidizing agent
peroxide
toothpaste
adult
article
chemistry
clinical trial
controlled study
dental procedure
drug mixture
human
methodology
middle aged
safety
tooth discoloration
LA - English
PY - 2004
SN - 0894-8275
SP - 75-79
ST - Efficacy and safety assessment of a new liquid tooth whitening gel containing
5.9% hydrogen peroxide
T2 - Am J Dent
TI - Efficacy and safety assessment of a new liquid tooth whitening gel containing
5.9% hydrogen peroxide
VL - 17
ID - 14242
ER -
TY - JOUR
AB - Periodontitis is admittedly a microbe-driven intractable infectious disease,
in which Porphyromonas gingivalis (Pg) plays a keystone role. Pg can selectively
impair the antimicrobial responses of periodontal resident macrophages including
their phagocytic and bactericidal activity without interfering their
proinflammatory activity, which leads to microflora disturbance, destructive
periodontal inflammation and alveolar bone loss eventually. Here, an injectable
ROS-sensitive hydrogel is developed for releasing active bone marrow-derived
macrophages (named ex-situ macrophages hereafter) and a complement C5a receptor
antagonist (C5A) to the gingival crevice. Through appropriately tuning the hydrogel
stiffness, the phagocytic activity of these macrophages is greatly enhanced,
reaching an optimal performance at the elastic modulus of 106 kPa. Meanwhile, C5A
avoids undesired C5a receptor activation by Pg to ensure the bacterial killing
activity of both the ex-situ and in-situ macrophages. Besides, the ROS-sensitive
hydrogels show another distinct feature of decreasing the ROS level in periodontal
niche, which contributes to the alleviated periodontal inflammation and attenuated
bone loss as well. This study highlights the potential of utilizing hydrogels with
tailored biomechanical properties to remodel the functions of therapeutic cells,
which is expected to find wide applications even beyond periodontitis treatment.
AN - rayyan-563562037
AU - Gan, Z. Q.
AU - Xiao, Z. C.
AU - Zhang, Z.
AU - Li, Y.
AU - Liu, C.
AU - Chen, X.
AU - Liu, Y. B.
AU - Wu, D. L.
AU - Liu, C. F.
AU - Shuai, X. T.
AU - Cao, Y.
DO - 10.1016/j.bioactmat.2023.01.011
PY - 2023
SN - 2452-199X
SP - 347-359
ST - Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a
receptor antagonist modulates antibacterial activity of macrophages for
T2 - BIOACTIVE MATERIALS
TI - Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a
VL - 25
Y2 - 7
ID - 15411
ER -
TY - JOUR
AB - Periodontitis is admittedly a microbe-driven intractable infectious disease,
in which Porphyromonas gingivalis (Pg) plays a keystone role. Pg can selectively
impair the antimicrobial responses of periodontal resident macrophages including
their phagocytic and bactericidal activity without interfering their
proinflammatory activity, which leads to microflora disturbance, destructive
periodontal inflammation and alveolar bone loss eventually. Here, an injectable
ROS-sensitive hydrogel is developed for releasing active bone marrow-derived
macrophages (named ex-situ macrophages hereafter) and a complement C5a receptor
antagonist (C5A) to the gingival crevice. Through appropriately tuning the hydrogel
stiffness, the phagocytic activity of these macrophages is greatly enhanced,
reaching an optimal performance at the elastic modulus of 106 kPa. Meanwhile, C5A
avoids undesired C5a receptor activation by Pg to ensure the bacterial killing
activity of both the ex-situ and in-situ macrophages. Besides, the ROS-sensitive
hydrogels show another distinct feature of decreasing the ROS level in periodontal
niche, which contributes to the alleviated periodontal inflammation and attenuated
bone loss as well. This study highlights the potential of utilizing hydrogels with
tailored biomechanical properties to remodel the functions of therapeutic cells,
which is expected to find wide applications even beyond periodontitis treatment.
AN - rayyan-563559695
AU - Gan, Z.
AU - Xiao, Z.
AU - Zhang, Z.
AU - Li, Y.
AU - Liu, C.
AU - Chen, X.
AU - Liu, Y.
AU - Wu, D.
AU - Shuai, X.
AU - Cao, Y.
DO - 10.1016/j.bioactmat.2023.01.011
confocal microscope
diagnostic kit
ELISA kit
flow cytometer
fluorescence imaging system
imaging software
micro-CT scanner
microplate reader
microscope
trap staining kit
complement component C5a receptor antagonist
F actin
hydrogel
interleukin 1beta
interleukin 6
lipopolysaccharide
nitric oxide
polyvinyl alcohol
animal cell
animal experiment
animal model
article
biosafety
bone development
controlled study
human
human cell
immunofluorescence
in vitro study
macrophage
male
MC3T3-E1 cell line
nonhuman
osteoclastogenesis
periodontitis
phagocytosis
rat
RAW 264.7 cell line
LA - English
PY - 2023
SN - 2452-199X
SP - 347-359
ST - Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a
T2 - Bioact. Mater.
TI - Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a
VL - 25
ID - 13069
ER -
TY - JOUR
AB - Background and Objective: Healthy subjects who do not have Aggregatibacter
actinomycetemcomitans in their oral cavity may possess factors in saliva that might
demonstrate antibacterial activity against the bacterium. The aim of this study was
to identify and purify proteins from saliva of healthy subjects that might
demonstrate antibacterial activity against A. actinomycetemcomitans and test the
same against the bacteria. Material and Methods: Saliva from 10 healthy volunteers
was tested individually for its anti-A. actinomycetemcomitans activity. Among the
10 subjects, eight demonstrated anti-A. actinomycetemcomitans activity. Saliva was
collected from one healthy volunteer who demonstrated the highest antimicrobial
activity against A. actinomycetemcomitans. After clarifying the saliva, it was
subjected to an affinity chromatography column with A. actinomycetemcomitans. The
proteins bound to A. actinomycetemcomitans were eluted from the column and
identified using mass spectrometry (MALDI-TOF/TOF MS). Among other proteins that
bound to A. actinomycetemcomitans, which included lactoferrin, immunoglobulinA and
kallikrein, cystatinSA was observed in significantly higher concentrations, and
this was purified from the eluate. The purified cystatin SA was tested at different
concentrations for its ability to kill A. actinomycetemcomitans in a 2h cell
killing assay. The bacteria were also treated with a proteinase inhibitor,
leupeptin, to clarify whether the antimicrobial effect of cystatin SA was related
to its protease inhibitory function. CystatinSA was also tested for its ability to
prevent binding of A. actinomycetemcomitans to buccal epithelial cells (BECs) in an
A. actinomycetemcomitans-BEC binding assay. Results: Cystatin SA (0.1mg/mL)
demonstrated a statistically significant antimicrobial activity against A.
actinomycetemcomitans. The effect of cystatin SA decreased with lower
concentrations, with 0.01mg/mL showing no effect. The addition of monoclonal
cystatin SA antibodies to the purified sample completely negated the antimicrobial
effect. Treatment of A. actinomycetemcomitans with leupeptin resulted in no
antimicrobial effect, suggesting that the antimicrobial activity of cystatin SA is
independent of its protease inhibitory function. A. actinomycetemcomitans
pretreated with cystatin SA showed reduced binding to BECs, suggesting a potential
role for cystatin SA in decreasing the colonization of A. actinomycetemcomitans.
Conclusion: The present study shows that cystatin SA demonstrates antimicrobial
activity against the periodontopathogen A. actinomycetemcomitans, and future
studies determining the mechanism of action are necessary. The study also shows the
ability of cystatin SA to reduce significantly the binding of A.
actinomycetemcomitans to BECs. © 2012 John Wiley & Sons A/S.
AN - rayyan-563560527
AU - Ganeshnarayan, K.
AU - Velliyagounder, K.
AU - Furgang, D.
AU - Fine, D. H.
DO - 10.1111/j.1600-0765.2012.01481.x
IS - 5
cathepsin
CST2 protein, human
cystatin S
kallikrein
lactoferrin
leupeptin
proteinase K
secretory immunoglobulin
affinity chromatography
article
bacterium adherence
confocal microscopy
cytology
drug antagonism
drug effect
epithelium cell
human
mass spectrometry
microbiology
mouth mucosa
saliva
time
LA - English
PY - 2012
SN - ["0022-3484", "1600-0765"]
SP - 661-673
ST - Human salivary cystatin SA exhibits antimicrobial effect against
TI - Human salivary cystatin SA exhibits antimicrobial effect against
VL - 47
ID - 13901
ER -
TY - JOUR
AB - Abstract: The objective of this study was to prepare periodontal gels using
natural polymers such as badam gum, karaya gum and chitosan. These gels were tested
for their physical and biochemical properties and assessed for their antibacterial
activity against Aggregatibacter actinomycetemcomitans and Streptococcus mutans,
two pathogens associated with periodontal disease. Badam gum, karaya gum and
chitosan were used to prepare gels of varying concentrations. Moxifloxacin
hydrochloride, a known antimicrobial drug was choosen in the present study and it
was added to the above gels. The gels were then run through a battery of tests in
order to determine their physical properties such as pH and viscosity. Diffusion
studies were carried out on the gels containing the drug. Antimicrobial testing of
the gels against various bacteria was then carried out to determine the
effectiveness of the gels against these pathogens. The results showed that natural
polymers can be used to produce gels. These gels do not have inherent antimicrobial
properties against A. actinomycetemcomitans and S. mutans. However, they can be
used as a transport vehicle to carry and release antimicrobial drugs. Graphical
Abstract: [InlineMediaObject not available: see fulltext.]
AN - rayyan-563560308
AU - Ganguly, A.
AU - Ian, C. K.
AU - Sheshala, R.
AU - Sahu, P. S.
AU - Al-Waeli, H.
AU - Meka, V. S.
DO - 10.1007/s10856-017-5852-4
IS - 3
KW - badam gum
chitosan
karaya gum
moxifloxacin
polymer
unclassified drug
article
controlled study
diffusion
gel
nonhuman
periodontal disease
pH
physical chemistry
priority journal
viscosity
LA - English
PY - 2017
SN - ["1573-4838", "0957-4530"]
ST - Application of diverse natural polymers in the design of oral gels for the
treatment of periodontal diseases
TI - Application of diverse natural polymers in the design of oral gels for the
treatment of periodontal diseases
VL - 28
ID - 13682
ER -
TY - JOUR
AB - Background. Periodontitis can be treated by regenerating periodontal tissue
using a bone graft. Several natural materials such as chitosan and minerals such as
hydroxyapatite can be developed to increase periodontal tissue regeneration.
Chitosan has a high potential in healing wounds. Hydroxyapatite has excellent
properties such as biocompatibility, osteoconductive, osteoinductive, and
osteogenesis, making it an ideal material for soft and hard tissue regeneration.
Chitosan and hydroxyapatite can be obtained from the shells of crustaceans, such as
crabs shells (Portunus pelagicus). Objective. To assess the effectiveness of the
combination of chitosan gel and hydroxyapatite powder as a bone graft on
periodontal tissue regeneration in experimental animals. Periodontal tissue
regeneration was assessed by expressing inflammatory cytokine gene indicators IL-1
and BMP-2. Methods. Experimental laboratory research and clinical trials with
posttest only control group design. Twenty-seven Wistar rats were divided into
three groups. Then the femoral bone defect was made, the positive control group was
given placebo gel, the positive control group was given BATAN hydroxyapatite, and
the test group was given a combination of chitosan gel and hydroxyapatite crab
shells. Wistar rats were sacrificed on days 7, 14, and 21, and the femur bone was
then taken for immunohistochemical analysis to determine the levels of IL-1 and
BMP-2. The Kolmogorov-Smirnov test, Levene test, and one-way ANOVA analyzed the
data. Results. On days 7, 14, and 21, the expression levels of IL-1 and BMP2 were
significantly different between the three groups. The group added with chitosan gel
and crab shell HA showed a faster decrease in IL-1 expression than the control
group. BMP-2 expression increased in the test group compared to the control group.
Conclusion. The combination of chitosan gel and hydroxyapatite inhibited the
production of proinflammatory cytokines and increased the production of BMP-2.
AN - rayyan-563559917
AU - Gani, A.
AU - Yulianty, R.
AU - Supiaty, S.
AU - Rusdy, M.
AU - Dwipa Asri, G.
AU - Eka Satya, D.
AU - Rahayu Feblina, A.
AU - Achmad, H.
DO - 10.1155/2022/1817236
KW - periosteum elevator
antiinfective agent
chitosan
gel
hydroxyapatite
interleukin 1
ketamine
mineral
placebo
animal experiment
animal model
animal shell
article
bone defect
bone graft
clinical assessment
clinical laboratory
controlled study
femur
human
Kolmogorov Smirnov test
nonhuman
periodontal network regeneration
periodontium
Portunus pelagicus
powder
pretest posttest design
rat
tissue regeneration
waste
LA - English
PY - 2022
SN - ["1687-8795", "1687-8787"]
ST - Effectiveness of Combination of Chitosan Gel and Hydroxyapatite from Crabs
Shells (Portunus pelagicus) Waste as Bonegraft on Periodontal Network Regeneration
through IL-1 and BMP-2 Analysis
T2 - Int. J. Biomater.
TI - Effectiveness of Combination of Chitosan Gel and Hydroxyapatite from Crabs
Shells (Portunus pelagicus) Waste as Bonegraft on Periodontal Network Regeneration
through IL-1 and BMP-2 Analysis
VL - 2022
ID - 13291
ER -
TY - JOUR
AB - The increasing morbidity of oral diseases, such as dental caries,
periodontitis and oral cancer, has greatly compromised the life quality of humans.
With the rapid development of biomaterials and nanotechnology, various
biomaterials-based systems have been reported to treat oral diseases. As the
biocompatible, biodegradable and bioadhesive polysaccharide biomaterials, chitosan
and its derivatives have also been widely used for the oral disease therapy, either
as the antibacterial agents, drug delivery carriers or tissue engineering
scaffolds. It has been well demonstrated that chitosan can significantly enhance
the therapy efficacy for various oral diseases, due to its intrinsic antibacterial
activity and controlled drug release feature. Herein, we aim to provide a
comprehensive understanding of the biological functions of chitosan, such as
antimicrobial, anticancer and remineralization activity, and summarize the
applications of chitosan-based therapeutic systems in treating the typical oral
diseases, including dental caries, endodontic diseases, periodontal diseases, oral
cancer, oral and maxillofacial surgery, and oral mucosal diseases. In addition, the
concerns and possible solutions of the clinical use of chitosan are also discussed.
AN - rayyan-563562358
AU - Gao, H. Y.
AU - Wu, N.
AU - Wang, N. N.
AU - Li, J.
AU - Sun, J.
AU - Peng, Q.
DO - 10.1016/j.ijbiomac.2022.10.090
PY - 2022
SN - ["0141-8130", "1879-0003"]
SP - 3178-3194
ST - Chitosan-based therapeutic systems and their potentials in treatment of oral
diseases
TI - Chitosan-based therapeutic systems and their potentials in treatment of oral
diseases
VL - 222
Y2 - 12 y3 - 1
ID - 15732
ER -
TY - JOUR
AB - The increasing morbidity of oral diseases, such as dental caries,
periodontitis and oral cancer, has greatly compromised the life quality of humans.
With the rapid development of biomaterials and nanotechnology, various
biomaterials-based systems have been reported to treat oral diseases. As the
biocompatible, biodegradable and bioadhesive polysaccharide biomaterials, chitosan
and its derivatives have also been widely used for the oral disease therapy, either
as the antibacterial agents, drug delivery carriers or tissue engineering
scaffolds. It has been well demonstrated that chitosan can significantly enhance
the therapy efficacy for various oral diseases, due to its intrinsic antibacterial
activity and controlled drug release feature. Herein, we aim to provide a
comprehensive understanding of the biological functions of chitosan, such as
antimicrobial, anticancer and remineralization activity, and summarize the
applications of chitosan-based therapeutic systems in treating the typical oral
diseases, including dental caries, endodontic diseases, periodontal diseases, oral
cancer, oral and maxillofacial surgery, and oral mucosal diseases. In addition, the
concerns and possible solutions of the clinical use of chitosan are also discussed.
AN - rayyan-563559789
AU - Gao, H.
AU - Wu, N.
AU - Wang, N.
AU - Li, J.
AU - Sun, J.
AU - Peng, Q.
DO - 10.1016/j.ijbiomac.2022.10.090
atorvastatin
benzydamine
biomaterial
calcium phosphate
celecoxib
chitosan
ciprofloxacin
dentin matrix protein 1
docetaxel
doxorubicin
doxycycline
ellagic acid
glass ionomer
graphene oxide
hyaluronic acid
hydrogel
ibuprofen
metal oxide nanoparticle
metronidazole
mifepristone
minocycline
polyacrylic acid
propolis
tideglusib
tripolyphosphate
antifungal activity
aphthous stomatitis
breast cancer
Candida albicans
dental caries
dental procedure
diabetic foot
Escherichia coli
glioblastoma
human
leukoplakia
lichen planus
MAPK signaling
mouth cancer
mouth disease
oral mucosal disease
oral mucositis
oral potentially malignant disorder
oral surgery
Penicillium expansum
periodontitis
Pi3K/Akt signaling
review
Serratia marcescens
tissue engineering
Wnt signaling
wound healing
LA - English
PY - 2022
SN - ["1879-0003", "0141-8130"]
SP - 3178-3194
ST - Chitosan-based therapeutic systems and their potentials in treatment of oral
diseases
TI - Chitosan-based therapeutic systems and their potentials in treatment of oral
diseases
VL - 222
ID - 13163
ER -
TY - JOUR
AB - The local treatment of periodontitis has recently received extensive
attention due to the advantages of mild systemic side effects and a high local drug
concentration. But the local drug delivery systems are not widely used in clinical
practice, and a major obstacle is the poor tissue permeability. In the present
study, we report a copper nanodot based ionic gel (Cu-NDs/IL gel) with favorable
tissue penetration capability, and it concurrently exhibits antibacterial and anti-
inflammatory functions. A Cu-NDs/IL gel was prepared by loading copper nanodots
(Cu-NDs) with triple enzyme-like activities into a multifunctional gel. The derived
Cu-NDs/IL gel possesses remarkable antibacterial properties attributed to the
peroxidase-like activity of Cu-NDs. In addition, Cu-NDs mimic superoxide dismutase
and catalase activities, which endow the gel with excellent free radical scavenging
capability in a neutral environment to relieve periodontal inflammation. More
importantly, the IL moiety in the Cu-NDs/IL gel promotes the penetration of Cu-NDs
into the gingival tissue, wherein the triple enzymatic activity of Cu-NDs may
function. In short, the Cu-NDs/IL gel has promising potential to serve as a topical
drug for periodontitis by promoting penetration, killing bacteria, and scavenging
ROS.
AN - rayyan-563562198
AU - Gao, Y. R.
AU - Zhang, W. X.
AU - Xue, R.
AU - Shu, Y.
AU - Wang, J. H.
DO - 10.1039/d3bm00309d
IS - 10
PY - 2023
SN - ["2047-4830", "2047-4849"]
SP - 3547-3560
ST - An ionic gel incorporating copper nanodots with antibacterial and antioxidant
dual functions for deep tissue penetration treatment of periodontitis in rats
T2 - BIOMATERIALS SCIENCE
TI - An ionic gel incorporating copper nanodots with antibacterial and antioxidant
VL - 11
Y2 - 5 y3 - 16
ID - 15572
ER -
TY - JOUR
AB - The local treatment of periodontitis has recently received extensive
attention due to the advantages of mild systemic side effects and a high local drug
concentration. But the local drug delivery systems are not widely used in clinical
practice, and a major obstacle is the poor tissue permeability. In the present
study, we report a copper nanodot based ionic gel (Cu-NDs/IL gel) with favorable
tissue penetration capability, and it concurrently exhibits antibacterial and anti-
inflammatory functions. A Cu-NDs/IL gel was prepared by loading copper nanodots
(Cu-NDs) with triple enzyme-like activities into a multifunctional gel. The derived
Cu-NDs/IL gel possesses remarkable antibacterial properties attributed to the
peroxidase-like activity of Cu-NDs. In addition, Cu-NDs mimic superoxide dismutase
and catalase activities, which endow the gel with excellent free radical scavenging
capability in a neutral environment to relieve periodontal inflammation. More
importantly, the IL moiety in the Cu-NDs/IL gel promotes the penetration of Cu-NDs
into the gingival tissue, wherein the triple enzymatic activity of Cu-NDs may
function. In short, the Cu-NDs/IL gel has promising potential to serve as a topical
drug for periodontitis by promoting penetration, killing bacteria, and scavenging
ROS.
AN - rayyan-563559772
AU - Gao, Y.
AU - Zhang, W.
AU - Xue, R.
AU - Shu, Y.
AU - Wang, J.
DO - 10.1039/d3bm00309d
animal model
animal tissue
article
controlled study
enzyme activity
gingival tissue
inflammation
male
nonhuman
periodontitis
periodontium
rat
antiinfective agent
antioxidant
catalase
copper
endogenous compound
free radical
peroxidase
quantum dot
LA - English
PY - 2023
SN - ["2047-4849", "2047-4830"]
ST - An ionic gel incorporating copper nanodots with antibacterial and antioxidant
T2 - Biomater. Sci.
TI - An ionic gel incorporating copper nanodots with antibacterial and antioxidant
ID - 13146
ER -
TY - JOUR
AB - Background: The present study was aimed to develop and optimize in situ gel
for the treatment of periodontal disease. Materials and Methods: Temperature-
sensitive in situ gel containing 0.1% w/v Chlorhexidine hydrochloride was
formulated by cold method using different polymers. Preliminary study was carried
out to optimize different types and concentration of polymers such as Poloxamer
188, Poloxamer 407, Gellan gum, and Carbopol 934P. Central composite design was
employed for optimization of the effect of independent variables such as Poloxamer
407 and Carbopol 934P on responses such as gelation temperature, spreadability,
cumulative percentage release at 2 h, and time for 50% drug release (t 50 %). Each
formulations were evaluated for clarity, pH, gelation temperature, spreadability,
drug content, in vitro drug release, t 50 %, and cumulative percentage drug release
at 2 h. Results: Results of evaluation parameters revealed that the drug release,
gelation temperature was considerably decreased with increasing t 50 % as the
concentration of each polymer was increased. The desirability function was utilized
to find out optimized formulation of the factorial design. Formulation F6 showed
the highest overall desirability of 0.6283 and, therefore, this formulation was
considered to be the optimized formulation. The % relative error was calculated,
which showed that observed responses were in close agreement with the predicted
values calculated from the generated regression equations. Conclusion: The clarity,
pH, drug content of all formulations was found to be satisfactory. Further, all the
formulations showed sustained drug release for a period of 6 h, which satisfied to
treat periodontal disease.
AN - rayyan-563560508
AU - Garala, K.
AU - Joshi, P.
AU - Shah, M.
AU - Ramkishan, A.
AU - Patel, J.
DO - 10.4103/2230-973X.108961
IS - 1
KW - carbomer
chlorhexidine
gellan
poloxamer
article
controlled study
drug formulation
drug release
factorial design
gel
gelation
in vitro study
molecular stability
periodontal disease
pH
priority journal
temperature
viscosity
LA - English
PY - 2013
SN - ["2230-973X", "2230-9713"]
SP - 29-41
ST - Formulation and evaluation of periodontal in situ gel
T2 - Int. J. Pharm. Invest.
TI - Formulation and evaluation of periodontal in situ gel
VL - 3
ID - 13882
ER -
TY - JOUR
AB - Background: Lycopene has biological properties and is widely used in medicine
these days. The purpose of this study was to compare the effects of lycopene, on
the physical and mechanical properties of the suture material, which is commonly
used in periodontal, oral and maxillofacial surgeries. Material and Method: The
lycopene gel was prepared and the suture material was dipped in it for 24 hrs.
Tensile strength, wound healing assay were evaluated. The presence of lycopene was
confirmed using SEM analysis. Result: The lycopene coating was well adhered to the
suture and results obtained by the wound healing assay demonstrated that the
presence of lycopene promoted cell migration and proliferation in the wound area
suggesting an active role of lycopene in the wound healing process. The tensile
strength was stable after 24 hrs. Conclusion: This research showed that the
antioxidant coatings developed on silk sutures may offer important advantages in
terms of prevention from surgical infections and wound healing process, and
suggested a novel approach towards antioxidant biomaterials for clinical practice.
AN - rayyan-563559715
AU - Garapati, B.
AU - Malaiappan, S.
AU - Navya, P. D.
DO - 10.47750/jptcp.2023.30.10.015
IS - 10
KW - scanning electron microscope
suture
antioxidant
lycopene
suture material
article
bacterial count
cell migration
cell proliferation
clinical practice
Escherichia coli
fibroblast
human
in vitro study
microbial colonization
tensile strength
wound healing
wound healing assay
LA - English
PY - 2023
SN - ["2561-8741", "1710-6222"]
SP - e101-e107
ST - Evaluation Of the Degradation, Microbial Colonization, Sustainability of
Physical and Mechanical Properties of Lycopene Coated Suture Materials - An In-
Vitro Study
T2 - J. Popul. ther. Clin. Pharmacol.
TI - Evaluation Of the Degradation, Microbial Colonization, Sustainability of
Physical and Mechanical Properties of Lycopene Coated Suture Materials - An In-
Vitro Study
VL - 30
ID - 13089
ER -
TY - JOUR
AB - It is generally not recommended that bonded restoration treatment should be
carried out immediately after bleaching treatment. However, the use of antioxidants
such as sodium ascorbate can be useful to avoid a waiting period. This article is a
brief review about in vitro proposals to overcome low bond strength values to
bleached dental surfaces. It shows a one-year follow-up case report of a young
female presenting agenesis of maxillary lateral incisors reshaped with direct resin
composite immediately after dental bleaching. Teeth were bleached with a
combination of in-office and at-home whitening protocols, followed by the
application of a 10% sodium ascorbate gel for one hour, to allow the immediate
reshaping with direct resin composite restoration. After one year, the clinical
performance of the restoration was successful. The use of sodium ascorbate gel can
help the clinician to perform bonding procedures immediately after bleaching
treatments.
AN - rayyan-563560544
AU - Garcia, E. J.
AU - Mena-Serrano, A.
AU - de Andrade, A. M.
AU - Reis, A.
AU - Grande, R. H.
AU - Loguercio, A. D.
IS - 2
KW - antioxidant
ascorbic acid
resin
adult
case report
congenital malformation
dental bonding
dental procedure
dental surgery
drug effect
enamel
female
follow up
human
hypodontia
incisor
methodology
periodontal disease
review
time
LA - English
PY - 2012
SN - 1862-0612
SP - 154-162
ST - Immediate bonding to bleached enamel treated with 10% sodium ascorbate gel: a
case report with one-year follow-up
T2 - Eur J Esthet Dent
TI - Immediate bonding to bleached enamel treated with 10% sodium ascorbate gel: a
case report with one-year follow-up
VL - 7
ID - 13918
ER -
TY - JOUR
AB - Purpose: To investigate the anti-gingivitis efficacy of a novel oral hygiene
routine consisting of a two-step stannous fluoride dentifrice and hydrogen peroxide
whitening gel system, an interactive oscillating-rotating electric toothbrush, and
expanded polytetrafluoroethylene floss.Methods: A total of 52 participants
(n=52;mean age 35.8±11.23 years) were enrolled in the study and randomized 1:1 to
the experimental hygiene group or control (dental prophylaxis followed by use of
standard sodium fluoride dentifrice and a manual toothbrush). Participants were
instructed to brush twice daily; those in the experimental group were instructed to
floss once daily. Oral examinations were conducted at Baseline, Week 2, Week 4, and
Week 6.Results: Both groups experienced significant declines in the mean number of
bleeding sites from Baseline at all time points, evident as early as Week 2.
Bleeding sites continued to decline throughout the trial in the experimental group,
whereas they showed an increasing trend between Weeks 2 and 6 in the control group.
The experimental group had 55% fewer bleeding sites at Week 2, 85% fewer bleeding
sites at Week 4, and 98% fewer bleeding sites at Week 6 (p<0.0001 for all) as
compared to the control group. At Week 6, 84% of participants in the experimental
group had no bleeding, while all participants in the control group had
bleeding.Conclusion: The experimental oral hygiene group showed significantly
greater reductions in gingival bleeding than the control oral hygiene group, with
benefits seen as early as Week 2 and increasing over the six-week study.
AN - rayyan-563560240
AU - Garcia-Godoy, C. E.
AU - Flores, K. L.
AU - Klukowska, M. A.
AU - Conde, E. L.
AU - Gerlach, R. W.
IS - 5
hydrogen peroxide
tin fluoride
toothpaste
adult
comparative study
controlled study
devices
female
gel
gingiva bleeding
gingivitis
human
male
middle aged
mouth hygiene
procedures
tooth brushing
young adult
LA - English
PY - 2018
SN - 1553-0205
SP - 45-51
ST - A Comparison of Oral Hygiene Products and Professional Care: A six-week
T2 - J Dent Hyg
TI - A Comparison of Oral Hygiene Products and Professional Care: A six-week
VL - 92
ID - 13614
ER -
TY - JOUR
AB - PURPOSE: To assess use of a two-step dentifrice/gel sequence versus
chlorhexidine gluconate mouthrinse on gingivitis prevention after dental
prophylaxis. METHODS: A 12-week, randomized controlled trial was conducted to
compare the effectiveness and safety of a two-step dentifrice/gel sequence to a
positive control in healthy adults with established gingivitis. After informed
consent, gingivitis and stain levels were assessed by clinical examination.
Eligible subjects received a dental prophylaxis and were randomly assigned to twice
daily unsupervised use of either (1) two-step oral hygiene sequence:0.454% stannous
fluoride dentifrice followed by 3.0% hydrogen peroxide whitening gel for the test
group; or (2) 0.12% chlorhexidine gluconate oral rinse and 0.76% sodium
monofluorophosphate dentifrice for the control group. Clinical measurements of
gingivitis bleeding sites and tooth stain area/intensity were collected after 4, 8
and 12 weeks use, while safety was assessed via clinical examination and oral
status interview of the subjects. RESULTS: A total of 44 subjects were enrolled and
35 completed the 12-week study. At baseline, bleeding sites ranged from 10-33.
After prophylaxis and assigned treatment, both groups exhibited significant (P≤
0.0001) reductions in bleeding sites. Responses were directionally better in the
two-step sequence at all post-baseline timepoints, with groups differing
significantly (P < 0.05) at Week 8. Tooth stain measurements demonstrated that the
two-step dentifrice/gel sequence did not contribute to any significant (P> 0.13)
stain accumulation. In contrast, stain accumulation was evident (P< 0.003) in the
chlorhexidine group beginning at the Week 4 visit. Adverse events were more common
in the positive control, and contributed to early termination. CLINICAL
SIGNIFICANCE: Twice daily use of a two-step stannous fluoride dentifrice and
peroxide whitening gel sequence after prophylaxis provided comparable or superior
gingivitis benefits to chlorhexidine gluconate rinse without the concomitant side
effect of staining.
AN - rayyan-563560251
AU - Garcia-Godoy, C.
AU - Rothrock, J.
AU - Gurich, N.
AU - Anastasia, M. K.
AU - Gerlach, R. W.
KW - chlorhexidine
mouthwash
sodium fluoride
tin fluoride
toothpaste
adult
controlled study
gel
gingivitis
human
tooth discoloration
LA - English
PY - 2018
SN - 0894-8275
SP - 18A-23A
ST - Post-prophylaxis gingivitis prevention with two-step stannous fluoride
dentifrice plus whitening gel sequence or chlorhexidine gluconate mouthrinse
T2 - Am J Dent
TI - Post-prophylaxis gingivitis prevention with two-step stannous fluoride
dentifrice plus whitening gel sequence or chlorhexidine gluconate mouthrinse
VL - 31
ID - 13625
ER -
TY - JOUR
AB - Introduction: Biomaterial-based scaffold formulations (three-dimensional
Porous matrix, nano-fibre mesh, hydrogels and microspheres) are the major
components that are used to deliver the bioactive molecules into the body organs
through different routes for an effective treatment of various diseases. Areas
covered: Various fabrication techniques such as freeze-drying, polymerisation,
spray drying, gas foaming, supercritical fluid technology, etc., are successfully
used for fabrication of scaffold formulations. Due to their unique characteristics,
these formulations are widely used against various diseases such as tuberculosis,
bone defects, cartilage repair, skin diseases, cardiovascular diseases, periodontal
diseases, wound dressing, etc. Expert opinion: The study of biomaterial-based
scaffold formulations is exhilarating with novel approaches to drug/cell/gene
delivery being developed all the time. At present, there is a huge extent of
research being performed worldwide on all aspects of tissue engineering/drug or
gene delivery. In the future, the main focus will be on the development of more
patient compliant, sustained and controlled delivery systems against various
diseases by modification of polymers, manufacturing technologies as well as carrier
systems. © Informa UK, Ltd.
AN - rayyan-563560436
AU - Garg, T.
AU - Goyal, A. K.
DO - 10.1517/17425247.2014.891014
IS - 5
KW - biomaterial
ciprofloxacin
clotrimazole
cyanocobalamin
cyclophane derivative
diclofenac
fenretinide
fluorouracil
gentamicin
ibuprofen
imidazole derivative
indometacin
infliximab
insulin
lidocaine
mepacrine
metformin
microsphere
moxifloxacin
nanofiber
ornidazole
polymer
propranolol
recombinant DNA
rutoside
silver
silver imidazole cyclophane
simvastatin
tacrolimus
triclosan
unclassified drug
adhesion
binding affinity
biocompatibility
biodegradability
bone defect
cardiovascular disease
cartilage
chondrocyte
chemical analysis
density
diffusion
embryonic stem cell
endothelial progenitor cell
endothelium cell
flow kinetics
foaming
freeze drying
gas
gel
gelation
cardiac muscle cell
human
hydrogel
in vitro study
in vivo study
kidney cell
melting point
morphology
nanofabrication
nonhuman
osteoblast
pancreas islet cell
PC12 cell line
periodontal disease
polymerization
porosity
review
skeletal muscle satellite cell
skin disease
spray drying
stem cell
strength
supercritical fluid
thermal analysis
tissue engineering
tuberculosis
wound dressing
LA - English
PY - 2014
SN - ["1744-7593", "1742-5247"]
SP - 767-789
ST - Biomaterial-based scaffolds-current status and future directions
T2 - Expert Opin. Drug Deliv.
TI - Biomaterial-based scaffolds-current status and future directions
VL - 11
ID - 13810
ER -
TY - JOUR
AB - Scaffolds are implants or injects, which are used to deliver cells, drugs,
and genes into the body. Different forms of polymeric scaffolds for cell/drug
delivery are available: (1) a typical three-dimensional porous matrix, (2) a
nanofibrous matrix, (3) a thermosensitive sol-gel transition hydrogel, and (4) a
porous microsphere. A scaffold provides a suitable substrate for cell attachment,
cell proliferation, differentiated function, and cell migration. Scaffold matrices
can be used to achieve drug delivery with high loading and efficiency to specific
sites. Biomaterials used for fabrication of scaffold may be natural polymers such
as alginate, proteins, collagens, gelatin, fibrins, and albumin, or synthetic
polymers such as polyvinyl alcohol and polyglycolide. Bioceramics such as
hydroxyapatites and tricalcium phosphates also are used. Techniques used for
fabrication of a scaffold include particulate leaching, freeze-drying,
supercritical fluid technology, thermally induced phase separation, rapid
prototyping, powder compaction, sol-gel, and melt moulding. These techniques allow
the preparation of porous structures with regular porosity. Scaffold are used
successfully in various fields of tissue engineering such as bone formation,
periodontal regeneration, repair of nasal and auricular malformations, cartilage
development, as artificial corneas, as heart valves, in tendon repair, in ligament
replacement, and in tumors. They also are used in joint pain inflammation,
diabetes, heart disease, osteochondrogenesis, and wound dressings. Their
application of late has extended to delivery of drugs and genetic materials,
including plasmid DNA, at a controlled rate over a long period of time. In
addition, the incorporation of drugs (i.e., inflammatory inhibitors and/or
antibiotics) into scaffolds may be used to prevent infection after surgery and
other disease for longer duration. Scaffold also can be used to provide adequate
signals (e.g., through the use of adhesion peptides and growth factors) to the
cells, to induce and maintain them in their desired differentiation stage, and to
maintain their survival and growth. The present review gives a detailed account of
the need for the development of scaffolds along with the materials used and
techniques adopted to manufacture scaffolds for tissue engineering and for
prolonged drug delivery. © 2012 Begell House, Inc.
AN - rayyan-563560563
AU - Garg, T.
AU - Singh, O.
AU - Arora, S.
AU - Murthy, R. S. R.
DO - 10.1615/CritRevTherDrugCarrierSyst.v29.i1.10
IS - 1
KW - agar
alginic acid
bioceramics
biomaterial
carrageenan
cellulose
chitosan
chondroitin sulfate
collagen
dextran
elastin
fibrin
galactose
gelatin
gellan
heparin
hyaluronic acid
macrogol
microsphere
poly(ortho ester)
polyamidoamine
polyanhydride
polybutylene terephthalate
polyester
polymer
polypyrrole
silk fibroin
starch
tissue scaffold
unindexed drug
binding affinity
biocompatibility
biodegradability
chemical structure
composite material
electrospinning
emulsion
emulsion templating
fiber bonding
fiber mesh technique
freeze drying
fused deposition modeling
gas foaming method
human
hydrogel
kinetics
melt molding technique
membrane
nonhuman
organ printing
particulate leaching method
porosity
powder compaction
procedures
rapid prototyping
review
selective laser sintering
sol-gel
soybean
stereolithography
supercritical fluid
thermally induced phase separation
tissue engineering
Apligraf
Artz
Biomend
Bionect
BIOPOLGO4
BIOPOLP05
Collagraft
CryoSeal
CultiSpher-G
EmbryoGlue
Forta-Derm
Gelfilm
Gelfoam
GeniaBeads CN
Healon
Healos
HemCon
Hyaff
Hyalgan
Hyalubrix
Natrosol 250HX
Nu-Derm
Opegan R
Revitix
Surgifoam
VCTO1
Viscoat
Vivostat
LA - English
PY - 2012
SN - 0743-4863
SP - 1-63
ST - Scaffold: A novel carrier for cell and drug delivery
TI - Scaffold: A novel carrier for cell and drug delivery
VL - 29
ID - 13937
ER -
TY - JOUR
AB - ObjectiveTo provide a systematic overview on the efficacy of green tea
catechin as an adjunct to scaling and root planing (SRP) in terms of probing pocket
depth (PPD).Materials and methodsA systematic literature search was performed using
electronic databases in PubMed, Scopus, Medline, Cochrane, CINAHL, and Web of
Science on randomized clinical trials up to January 2017. The research question was
posed in accordance with PRISMA guidelines.ResultsThe search provided 234 studies.
After analyzing the full texts, five studies were included, with four studies
qualifying for meta-analysis. Mean PPD reduction was significantly higher (=0.05)
when green tea catechin was used as an adjunct to SRP (test group) than with SRP
alone (control group). The difference in the reduction was 0.74mm [0.35-1.13; 95%
CI].ConclusionThe local application of green tea catechin as an adjunct to SRP may
result in a beneficial reduction in PPD. Due to the highly heterogeneous data and
some risk of bias, however, this data still needs to be interpreted with
caution.Clinical relevanceThe finding suggests that green tea catechin may be a
topical adjunct to SRP without negative side effects.
AN - rayyan-563562487
AU - Gartenmann, S. J.
AU - von Weydlich, Y.
AU - Steppacher, S. L.
AU - Heumann, C.
AU - Attin, T.
AU - Schmidlin, P. R.
DO - 10.1007/s00784-018-2684-7
IS - 1
PY - 2019
SN - ["1432-6981", "1436-3771"]
SP - 1-20
ST - The effect of green tea as an adjunct to scaling and root planing in non-
surgical periodontitis therapy: a systematic review
TI - The effect of green tea as an adjunct to scaling and root planing in non-
surgical periodontitis therapy: a systematic review
VL - 23
Y2 - 1
ID - 15861
ER -
TY - JOUR
AB - This review mainly emphasizes on properties and recent applications of
various natural polymers (Naturapolyceutics) used in the drug delivery development
process including alginate, chitosan, starch, cellulose, gums, etc.
Naturapolyceutics is the platform that blends natural polymers and pharmaceutics
for the design and development of drug delivery systems. Natural polymers due to
their biological properties, sustainability, human and eco-friendliness are
promising in this field. Polymers as an excipient influence drug release and should
be compatible, non-toxic, stable, economic etc. Nowadays, due to many problems
associated with drug release and side effects, manufacturers are inclined towards
using natural polymers. In the future, these natural materials have many advantages
over synthetic ones as they are non-toxic and most important, a constant rate of
drug release can be achieved from a natural polymer-based controlled release
device.
AN - rayyan-563560146
AU - Gaur, N.
AU - Mishra, S.
AU - Srivastava, S.
AU - Parvez, N.
DO - 10.31838/ijpr/2020.SP1.224
KW - dental dressing
10 hydroxycamptothecin
algaroba
alginic acid
aminosalicylic acid
amphotericin B
budesonide
candesartan hexetil
cefquinome
cellulose
chitosan
ciprofloxacin
curcumin
dehydroabietic acid
diclofenac
donepezil
doxorubicin
econazole
etoricoxib
fluoride
fluorouracil
flurbiprofen
galactomannan
gelatin
guar gum
gum arabic
hydrogel
indometacin
ketoprofen
ketoprofen lysine
mesalazine
methylene blue
microsphere
nanoparticle
natural polymer
nicotine
paclitaxel
pectin
polymer
quercetin
rosin
sparfloxacin
starch
toothpaste
unclassified drug
ursolic acid
zidovudine
Abelmoschus
Aloe
article
bioavailability
biocompatibility
breast cancer
cross linking
drug dosage form
drug formulation
encapsulation
human
micelle
nanotechnology
naturapolyceutics
periodontitis
pharmaceutics
wound healing
LA - English
PY - 2020
SN - 0975-2366
SP - 1866-1885
ST - Naturapolyceutics – emerging science & technology in drug delivery system
T2 - Int. J. Pharm. Res.
TI - Naturapolyceutics – emerging science & technology in drug delivery system
VL - 12
ID - 13520
ER -
TY - JOUR
AB - Periodontitis is an inflammatory disorder which is characterized by microbial
colonization of periodontal pockets which ultimately leads to the bacterial plaques
and tooth loosening. Therefore it is a common infection which is to be taken care
of in the present scenario as it can occur in individuals belonging to any gender
or race. Various drug delivery systems containing both antibiotics as well as plant
extracts are in use to improve the clinical symptoms of periodontitis. However the
preferred one being the one which incorporates antibiotics in it. Moreover local
drug delivery systems are more appropriate for use due to their site specificity
and requirement of low therapeutic dose resulting in reduction in undesirable
peripheral side effects. The present review elaborates the various treatment
modalities employed to treat periodontitis.
AN - rayyan-563560452
AU - Gaus, M.
AU - Nabi, B.
IS - 2
KW - amoxicillin
antibiotic agent
cephalosporin
chlorhexidine
clindamycin
doxycycline hyclate
gatifloxacin
listerine
macrolide
metronidazole
mouthwash
ornidazole
oxacillin
tetracycline
triclosan
antibiotic therapy
article
causal attribution
diabetes mellitus
disease predisposition
drug approval
drug degradation
drug formulation
drug release
erbium YAG laser
fiber
film
flap surgery
gel
general device
genetic variability
genotype
heredity
human
microemulsion
mouth hygiene
neodymium YAG laser
nonhuman
oral surgery
pathogenesis
periodontal chip
periodontitis
pneumonia
Sjoegren syndrome
smoking
physiological stress
tooth implant
tooth infection
unspecified side effect
actisite
arestin
atridox
elyzol
periochip:
periostat
LA - English
PY - 2014
SN - 0975-766X
SP - 2912-2932
ST - Recent advances in the treatment of periodontitis
T2 - Intl. J. Pharm. Technol.
TI - Recent advances in the treatment of periodontitis
VL - 6
ID - 13826
ER -
TY - JOUR
AB - The article highlights the data about local immunity of the patients having
cronic generalized periodontitis. Results of the conservative treatment with
adhesive balm Asepta, gel Hyaludent with metronidazole and clorhexidine and
Metrogyl Denta have shown the influence upon immunologic status of the patients.
AN - rayyan-563560615
AU - Gazhva, S. I.
AU - Voronina, A. I.
AU - Shkarednaia, O. V.
IS - 3
chlorhexidine
immunoglobulin A
immunoglobulin G
immunoglobulin M
metrogil denta
metronidazole
adult
article
drug combination
female
human
immunology
male
middle aged
mouth
LA - Russian
PY - 2010
SN - 0039-1735
SP - 30-33
ST - [Analysis of the oral cavity clinical immunological status in patients with
chronic generalized mild and moderate parodontitis when treated with antibacterial
means]
T2 - Stomatologiia (Mosk)
TI - [Analysis of the oral cavity clinical immunological status in patients with
chronic generalized mild and moderate parodontitis when treated with antibacterial
means]
VL - 89
ID - 13989
ER -
TY - JOUR
AB - Matrix metalloproteinases (MMPs) are a host cell-derived proteolytic enzyme
family which plays a major role in tissue-destructive inflammatory diseases such as
periodontitis. The aim of the present study was to evaluate the inhibitory effect
of chlorhexidine (CHX) on MMP-2 (gelatinase A), MMP-9 (gelatinase B), and MMP8
(collagenase 2) activity. Heat-denatured type I collagen (gelatin) was incubated
with pure human MMP-2 or -9 activated with p-aminophenylmercuric acetate (APMA),
and the proteolytic degradation of gelatin was monitored by sodium dodecyl sulfate-
polyacrylamide gel electrophoresis and Coomassie blue staining. The effect of CHX
on MMP-8 activity was also studied with a cellular model addressing the ability of
phorbol myristate acetate (PMA)-triggered human peripheral blood neutrophils
(polymorphonuclear leukocytes [PMNs]) to degrade native type I collagen. CHX
inhibited the activities of both gelatinases (A and B), but MMP-2 appeared to be
more sensitive than MMP-9. Adding calcium chloride to the assay mixtures almost
completely prevented the inhibition of MMP-9 activity by CHX, while the inhibition
of MMP-2 activity could be reversed only when CHX was used at a low concentration.
This observation suggests that CHX may act via a cation- chelating mechanism. CHX
dose-dependently inhibited collagenolytic activity of MMP-8 released by PMA-
triggered PMNs. MMP-8 without APMA activation was inhibited clearly more
efficiently than APMA-activated MMP-8. Our study suggests that the direct
inhibition of the MMPs' activities by CHX may represent a new valuable effect of
this antimicrobial agent and explains, at least in part, the beneficial effects of
CHX in the treatment of periodontitis.
AN - rayyan-563561015
AU - Gendron, R.
AU - Grenier, D.
AU - Sorsa, T.
AU - Mayrand, D.
DO - 10.1128/cdli.6.3.437-439.1999
IS - 3
KW - chlorhexidine
gelatinase A
gelatinase B
article
bacterial infection
chelation
drug effect
inflammation
nonhuman
periodontal disease
priority journal
protein degradation
protein denaturation
LA - English
PY - 1999
SN - 1071-412X
SP - 437-439
ST - Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by
chlorhexidine
T2 - Clin. Diagn. Lab. Immunol.
TI - Inhibition of the activities of matrix metalloproteinases 2, 8, and 9 by
chlorhexidine
VL - 6
ID - 14389
ER -
TY - JOUR
AB - Matrix metalloproteinases (MMPs) are capable of cleaving almost all
macromolecules of the extracellular connective tissue matrix and are thought to
play a major role in tissue destructive inflammatory diseases such as
periodontitis. The aim of this study was to determine the effects of siderophores,
which are iron-chelating molecules produced by a variety of microorganisms, on the
activity of MMP-2. Heat-denatured type I collagen (gelatin) was incubated with p-
aminophenylmercuric acetate-activated MMP-2 and siderophores. Degradation of
gelatin was monitored by SDS-PAGE and Coomassie blue staining. Ferrichrome,
rhodotorulic acid, desferoxamine mesylate and 2,3-dihydroxybenzoic acid were found
to inhibit the MMP-2 activity whereas beta-phenylpyruvic acid had no effect. The
inhibition could be reversed by adding an excess calcium chloride or ferric
chloride to the assay mixtures. Our study suggests that microbial siderophores may
represent new-potential therapeutic molecules for the treatment of destructive
inflammatory diseases involving excess MMP-2 activity, such as periodontitis.
AN - rayyan-563561013
AU - Gendron, R.
AU - Grenier, D.
AU - Sorsa, T.
AU - Uitto, V. J.
AU - Mayrand, D.
IS - 1
KW - 2 pyrocatechuic acid
2-pyrocatechuic acid
4 aminophenylmercuriacetate
4-aminophenylmercuriacetate
anazolene sodium
calcium chloride
chelating agent
chromium
collagen
deferoxamine
diagnostic agent
drug derivative
dyes, reagents, indicators, markers and buffers
enzyme inhibitor
ferric chloride
ferric ion
ferrichrome
fuchsine
gelatinase
gelatinase A
hydroxybenzoic acid derivative
iron chelating agent
metalloproteinase
phenylmercuric acetate
phenylpyruvic acid
piperazine derivative
rhodotorulic acid
siderophore
thiol reagent
article
bacterium
connective tissue
drug antagonism
drug effect
enzymology
human
macromolecule
metabolism
periodontitis
LA - English
PY - 1999
SN - 0022-3484
SP - 50-53
ST - Effect of microbial siderophores on matrix metalloproteinase-2 activity
TI - Effect of microbial siderophores on matrix metalloproteinase-2 activity
VL - 34
ID - 14387
ER -
TY - JOUR
AB - Objectives: To collect the experience of a group of dental hygienists in the
field of home dental hygiene. Their experience is compared with current evidence to
provide well-grounded indications on home dental hygiene. Materials and methods:
The experiences of 14 dental hygienists in different areas of home dental hygiene
were collected and compared. Recent literature was reviewed focusing on meta-
analyses and randomized trials. Results and conclusions: This study suggests useful
indications in different areas of home dental hygiene based on patients'
characteristics. According to the results, some clinical trials might be planned to
further evaluate the effectiveness of those indications. © 2009 Elsevier Srl. All
rights reserved.
AN - rayyan-563560650
AU - Genovesi, A. M.
AU - Sanavia, C.
AU - Marchisio, O.
AU - Lorenzi, C.
AU - Giacomelli, L.
AU - Bisacchi, F.
AU - Ricci, M.
AU - Nardi, G. M.
DO - 10.1016/j.pad.2009.07.002
IS - 1
KW - chlorhexidine
fluorine
mouthwash
rubber
toothpaste
article
biofilm
clinical trial
dental assistant
dental caries
dental device
dental floss
dental health education
disability
ergonomics
evidence based medicine
gauze dressing
gel
gingivitis
halitosis
home care
human
interpersonal communication
mouth hygiene
mucosa inflammation
orthodontics
patient compliance
periodontitis
saliva
toothbrush
toothpick
training
xerostomia
LA - Italian
PY - 2010
SN - 0393-9960
SP - 17-23
ST - Oral hygiene protocols: a literature review
T2 - Protocolli di igiene orale domiciliare. Indicazioni della letteratura
TI - Oral hygiene protocols: a literature review
VL - 36
ID - 14024
ER -
TY - JOUR
AB - Aims and Objectives: The purpose of this study was to assess the clinical and
microbiological effects of a newly developed root-conditioning gel system
containing tetracycline and a mixture of tetracycline and citric acid on non-
surgical periodontal therapy. Materials and Methods: Four anterior teeth from four
quadrants with a probing depth of 4-6 mm, in each of the 20 subjects with chronic
periodontitis, were subjected to four different modalities of treatment. A total of
80 teeths were divided into four groups of 20 teeth each taken from separate
quadrants, on the basis of one of the following four treatments: (1) Root planning
alone in first quadrant (RP group); (2) tetracycline-containing gel in the second
quadrant (TCG group); (3) root planning plus tetracycline-containing gel in third
quadrant (RP + TCG group); (4) root planning plus a mixture of tetracycline and
citric acid-containing gel in fourth quadrant (RP + TC-CAG group). Plaque index
(PI), sulcular bleeding index, probing pocket depth, and clinical attachment level
were measured for 0 day, 8 th week, and 12 th week, respectively. Subgingival
plaque samples from each site were collected at the same visits and examined with
dark field microscope for proportions of motile rods and spirochetes. Results: From
0 day to 12 th week, PI, sulcular bleeding index, probing pocket depth, and
clinical attachment levels decreased significantly in all the groups. From 0 day to
12 th week, RP + TC-CAG group showed a significantly higher change in the PI score.
From 0 day to 12 th week, RP group showed a significantly higher change in sulcular
bleeding index score. A significant decrease in probing pocket depth and gain in
clinical attachment level was noted at 12 th week in RP + TC-CAG group compared to
the other groups. A significant decrease in the proportion of motile rods was found
primarily in the RP + TC-CAG group. There was a decrease in the proportion of
spirochetes in all the groups. Conclusion: The results indicated that the use of a
mixture of tetracycline and citric acid-containing gel was effective in improving
gingival health and in changing subgingival microflora.
AN - rayyan-563560503
AU - George, R.
AU - Kumar, S.
AU - Ramakrishna, T.
AU - Emmadi, P.
AU - Ambalavanan, N.
DO - 10.4103/0970-9290.114949
IS - 1
citric acid
tetracycline
article
bacterial load
bacterium
classification
follow up
human
methodology
microbiology
periodontal disease
periodontal pocket
periodontics
spirochete
tooth plaque
LA - English
PY - 2013
SN - ["1998-3603", "0970-9290"]
SP - 52-59
ST - Effects of tetracycline-containing gel and a mixture of tetracycline and
citric acid-containing gel on non-surgical periodontal therapy
T2 - Indian J. Dent. Res.
TI - Effects of tetracycline-containing gel and a mixture of tetracycline and
VL - 24
ID - 13877
ER -
TY - JOUR
AB - Results of a study of 117 patients with chronic generalized parodontitis of
mild severity as well as clinical and functional characteristics of these patients
are presented. Dental indices in patients with this disorder were determined and
their dental status was identified. Statistical processing of the results was
carried out. A program of treatment using gum massage with chloride-sodium mineral
water, pelotherapy sludge and laeroporto with gel Canalsat was developed. It has
been established that positive changes were associated with complex application of
therapeutic measures. Effectiveness of the program was proven by positive dynamics,
such as reduction of hygienic index, bleeding index and the Ramfjord index, as well
as with increase of efficiency in comparison with the control group.
AN - rayyan-563560320
AU - Gerasimova, L. P.
AU - Khaibullina, R. R.
AU - Kabirova, M. F.
AU - Shamsiev, M. R.
IS - 1
chlorhexidine
metrogyl denta
mineral water
sodium chloride
unclassified drug
article
bleeding index
chronic disease
chronic generalized parodontitis
clinical indicator
comparative study
controlled study
disease severity
gel
gel canalsat
gingiva bleeding
gingiva disease
gingival swelling
gum massage
halitosis
human
hyperemia
laeroporto
laserophoresis
massage
mouth discomfort
mouth pain
mud therapy
oral hygiene index
osteoporosis
pelotherapy sludge
periodontitis
ramfjord index
rehabilitation care
LA - English
PY - 2017
SN - 0972-3005
SP - 242-245
ST - Rehabilitation in chronic generalized parodontitis
T2 - Asian J. Microbiol. Biotechnol. Environ. Sci.
TI - Rehabilitation in chronic generalized parodontitis
VL - 19
ID - 13694
ER -
TY - JOUR
AB - Rapid innovation in vital bleaching continues to expand the number of
treatment options available to patients, particularly in the area of at-home
whitening. The development of bleaching strips represented a new paradigm in the
delivery of peroxide. The efficacy and safety of bleaching strip systems delivering
up to 6.5% hydrogen peroxide has been established in numerous randomized clinical
trials. In 2003, a novel bleaching strip with 14% hydrogen peroxide (Crest®
Whitestrips® Supreme) was introduced. This advanced system carries a thinner but
more concentrated gel on each strip, resulting in a relatively similar total amount
of peroxide as compared to other strip systems. This 2-variable change, higher
concentration gel with lowered gel volume translates to improved whitening without
adversely affecting oral soft tissue tolerability and irritation. This paper
provides an integrated review of 9 comparative clinical trials evaluating the
whitening response (six trials) and safety (nine trials) of this novel vital
bleaching system. Efficacy results for the 14% hydrogen peroxide strips were
significantly (p<0.05) better than the placebo or pooled positive controls
evaluated in the clinical trials assessing tooth color or shade. Adverse events
were similar in type to the other vital bleaching systems. Overall, the research of
408 patients showed generally better efficacy and similar to or better tolerability
for the 14% hydrogen peroxide strips compared to a selected group of marketed
positive bleaching controls.
AN - rayyan-563560871
AU - Gerlach, R. W.
AU - Barker, M. L.
DO - 10.5005/jcdp-5-1-1
IS - 1
hydrogen peroxide
placebo
clinical trial
comparative study
dental procedure
dental device
gel
gingivitis
human
review
safety
self care
soft tissue
stomatitis
tooth color
tooth disease
tooth plaque
treatment outcome
Creast Whitestrips Supreme
Day White 9.5%
Nite White Excel3 16%
Opalescence 10%
Opalescence 20% F
Rembrandt XTRA Comfort
LA - English
PY - 2004
SN - 1526-3711
SP - 1-14
ST - Professional vital bleaching using a thin and concentrated peroxide gel on
whitening strips: An integrated clinical summary
TI - Professional vital bleaching using a thin and concentrated peroxide gel on
whitening strips: An integrated clinical summary
VL - 5
ID - 14245
ER -
TY - JOUR
AB - PURPOSE: Health-related outcomes from three randomized controlled trials
represented the initial research on the feasibility of novel, sequential oral
hygiene with a stannous fluoride (SnF₂) dentifrice then hydrogen peroxide (H₂O₂)
whitening gel. METHODS: One crossover and two parallel clinical trials were
conducted independently. Objectives varied, with individual studies assessing
short, intermediate or longer-term outcomes from breath, dental plaque or
gingivitis, respectively. Treatments were randomly assigned, and blinded test kits
were dispensed containing either: 1) a two-step 0.454% SnF₂ dentifrice and then a
3% H₂O₂ whitening gel sequence and instructions specifying 1+1 minute sequential
brushing (experimental); or 2) 0.76% sodium monofluorophosphate dentifrice (Colgate
Cavity Protection) and instructions for twice daily use (control). Standard methods
were used to measure efficacy (volatile sulfur compounds, plaque area coverage or
gingival bleeding) and safety (clinical examination and interview), and to compare
treatment responses. RESULTS: Overall, 165 subjects participated in the three
trials. Relative to baseline, only the experimental group exhibited significant (P<
0.05) improvements at initial and subsequent timepoints in each trial. Between-
group comparisons showed significant (P< 0.05) 30-45% reductions in breath malodor
(VSC), plaque (area%) and gingivitis (bleeding sites) favoring the experimental
group. Adverse event occurrences were infrequent, mild in severity, and unrelated
to dropout. CLINICAL SIGNIFICANCE: Important health-related outcomes from three
initial clinical trials established the feasibility of sequential brushing with a
two-step 0.454% SnF₂ dentifrice and then a 3% H₂O₂ whitening gel.
AN - rayyan-563560249
AU - Gerlach, R. W.
AU - Sagel, P. A.
KW - hydrogen peroxide
sodium fluoride
tin fluoride
toothpaste
controlled study
gingivitis
human
plaque index
tooth plaque
LA - English
PY - 2018
SN - 0894-8275
SP - 7A-12A
ST - Initial evidence of two-step dentifrice/gel sequence effects on health:
Outcomes from three randomized controlled trials
T2 - Am J Dent
TI - Initial evidence of two-step dentifrice/gel sequence effects on health:
Outcomes from three randomized controlled trials
VL - 31
ID - 13623
ER -
TY - JOUR
AB - Objectives: The combination of mineral trioxide aggregate (MTA) and 2%
chlorhexidine (CHX) has been recently introduced as an intracanal medicament. The
aim of this study was to evaluate the potential cytotoxic effects of MTA mixed with
2% chlorhexidine gel on human periodontal ligament stem cells (PDLSCs) and compare
it with other common endodontic regeneration medicaments. Materials and Methods:
Minimum inhibitory concentration and minimum bactericidal concentration of six
experimental groups against Enterococcus faecalis was determined. The study groups
consisted of RetoMTA mixed with 2% chlorhexidine gel (MTA+CHX), calcium hydroxide
(CH), CH mixed with CHX gel, two concentrations of double antibiotic paste, and 2%
CHX. The direct cytotoxic effect of minimum bactericidal concentration was
evaluated by MTT on PDLSCs on days 1, 3, and 7. One-way ANOVA and post hoc tests
were used for data analysis (P<0.05). Results: The viability of cells treated with
MTA+CHX decreased significantly over time (P<0.05) making this group the most
cytotoxic intracanal medicament on the 3(rd) and 7(th) days of treatment. On day
one, the highest viability percentage was detected in the CH+CHX group followed by
the CHX group. On day 3, CH+CHX and CHX groups displayed the highest viability
percentage. On day 7, the highest viability was observed in the CHX group, which
showed no significant difference with the control group (P=0.12). Conclusion:
Regarding the antimicrobial potency of intracanal medicaments at minimum
bactericidal concentration levels, CHX gel appears to be the least cytotoxic drug,
while MTA+CHX shows the highest reduction in viability percentage.
AN - rayyan-563561411
AU - Ghabraei, S.
AU - Afkhami, F.
AU - Shamshiri, A. R.
AU - Mohammadi, Z.
DO - 10.18502/fid.v20i1.12024
J2 - Front Dent
LA - eng
N1 - Department of Endodontics, School of Dentistry, Tehran University of Medical
Sciences, Tehran, Iran.; Department of Endodontics, School of Dentistry, Tehran
University of Medical Sciences, Tehran, Iran.; Research Center for Caries
Prevention, Dentistry Research Institute, Tehran University of Medical Sciences,
Tehran, Iran.; Department of Endodontics, School of Dentistry, Tehran University of
Medical Sciences, Tehran, Iran.
PY - 2023
SP - 1
ST - Comparison of Cytotoxicity between Mineral Trioxide Aggregate Mixed with
Chlorhexidine and Common Endodontic Regeneration Medicaments on Periodontal
Ligament Stem Cells: an in Vitro Study
T2 - Frontiers in dentistry
TI - Comparison of Cytotoxicity between Mineral Trioxide Aggregate Mixed with
Chlorhexidine and Common Endodontic Regeneration Medicaments on Periodontal
Ligament Stem Cells: an in Vitro Study
VL - 20
ID - 14785
ER -
TY - JOUR
AN - rayyan-563561912
AU - Ghadiri, M.
AU - Hau, H.
AU - Chrzanowski, W.
AU - Agus, H.
AU - Rohanizadeh, R.
DO - 10.1039/c3ra43217c
IS - 43
PY - 2013
SP - 20193-20201
ST - Laponite clay as a carrier for in situ delivery of tetracycline
T2 - RSC Advances
TI - Laponite clay as a carrier for in situ delivery of tetracycline
84886930874&doi=10.1039%2fc3ra43217c&partnerID=40&md5=14073c57da8c09b9c5a106a60f651
0c6
VL - 3
ID - 15286
ER -
TY - CHAP
AN - rayyan-563561471
AU - Ghaffar, A.
AU - Salman, M.
AU - Yameen, M.
AU - Iqbal, S. Z.
AU - Altaf, S.
AU - Munir, B.
DO - 10.1007/978-981-99-1655-9_12
PY - 2023
SP - 347-379
ST - Sustainable Biomedical Applications of Cellulose
T2 - Engineering Materials
TI - Sustainable Biomedical Applications of Cellulose
85156124356&doi=10.1007%2f978-981-99-1655-
9_12&partnerID=40&md5=2b22ca23804e173bf42f23e8da6d3519
ID - 14845
ER -
TY - JOUR
AB - Background. Use of herbal compounds as an intracanal medicament in the field
of endodontics has become noteworthy, one of which is the Aloe vera compound whose
antibacterial effect has already been proven in the planktonic form of Enterococcus
faecalis. The purpose of this study is to evaluate the antibacterial effect of Aloe
vera on E. faecalis biofilms at the 4th and 6th week of development. Materials and
Methods. 130 single root canal teeth without anomalies and caries were used. They
were divided into two groups of 65 teeth for four and six weeks of biofilm
production. Five samples of each group were examined for confirmation of biofilm
formation under an electron microscope. Study groups were investigated with an
antimicrobial agent as an intracanal medicament including 20 samples treated with
Aloe vera, calcium hydroxide, and phosphate-buffered saline, and biofilm and
survival of pathogens were investigated. Dentin chip suspensions were used for
colony-forming unit (CFU) counting to estimate remaining E. faecalis counts.
Results. The CFU mean in the 4th week subgroup in Aloe vera, phosphate-buffered
saline, and calcium hydroxide was 0, 69166.66 ± 31688.58, and 25000 ± 30822.07, and
in the 6th week, it was 136.36 ± 323.33, 95000 ± 12247.44, and 27501.66 ± 36570.34,
respectively, which showed a significant difference between the used materials
(p<0.05). Conclusion. Aloe vera, in contrast to calcium hydroxide, eliminated 4th
and 6th week biofilms and showed remarkable antibacterial properties against E.
faecalis biofilm. These results support potency of Aloe vera to use as a natural
antimicrobial material in the intracanal medicament.
AN - rayyan-563560156
AU - Ghasemi, N.
AU - Behnezhad, M.
AU - Asgharzadeh, M.
AU - Zeinalzadeh, E.
AU - Kafil, H. S.
DO - 10.1155/2020/8855277
KW - culture medium
electron microscope
calcium hydroxide
gel
herbaceous agent
phosphate buffered saline
Aloe vera
article
colony forming unit
comparative study
controlled study
descriptive research
human
human tissue
nonhuman
tooth root canal
LA - English
PY - 2020
SN - ["1687-8736", "1687-8728"]
ST - Antibacterial Properties of Aloe vera on Intracanal Medicaments against
Enterococcus faecalis Biofilm at Different Stages of Development
T2 - Int. J. Dent.
TI - Antibacterial Properties of Aloe vera on Intracanal Medicaments against
Enterococcus faecalis Biofilm at Different Stages of Development
VL - 2020
ID - 13530
ER -
TY - JOUR
AB - Background. This clinical study aimed to prepare and evaluate the effect of
antimicrobial nanocurcumin gel on reducing the microbial counts of gingival fluids
of the implant‒abutment interface in patients referred to the Tabriz Faculty of
Dentistry for the placement of two dental implants. Methods. Fifteen patients
applying for at least two dental implants were included in the study. During the
uncovering session, nanocurcumin gel was placed in one implant, and no substance
was placed in another (the control group). Then, in three sessions, implantation
sessions (10 days after the repair abutment closure session), prosthesis delivery
(15 days after the implantation session), and one month after prosthesis delivery,
the patients' gingival fluid was sampled and cultured to determine bacterial counts
in the gingival fluid by colony-forming units (CFU/mL). T-test was used for
statistical analysis of data, and statistical significance was set at P<0.05.
Results. This study showed that nanocurcumin gel significantly reduced the CFU/mL
of gingival fluid in all three sampling stages compared to the control group.
Conclusion. According to the results of this study, the application of
antimicrobial nanocurcumin gel inside the implant fixture could reduce the
microbial counts of gingival fluids.
AN - rayyan-563561235
AU - Ghavimi, M. A.
AU - Shahi, S.
AU - Sharifi, S.
AU - Noie Alamdari, A.
AU - Jamei Khosroshahi, A. R.
AU - Khezri, K.
DO - 10.34172/japid.2022.014
IS - 2
J2 - J Adv Periodontol Implant Dent
LA - eng
N1 - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tabriz
University of Medical Sciences, Tabriz, Iran.; Dental and Periodontal Research
Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Dental and
Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.;
Dental and Periodontal Research Center, Tabriz University of Medical Sciences,
Tabriz, Iran.; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry,
Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Pediatric
Dentistry, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz,
Iran.; Deputy of Food and Drug Administration, Urmia University of Medical
Sciences, Urmia, Iran.; Department of Nursing, Khoy University of Medical Sciences,
Khoy, Iran.
PY - 2022
SP - 114-118
ST - Antimicrobial effects of nanocurcumin gel on reducing the microbial count of
gingival fluids of implant‒abutment interface: A clinical study
T2 - Journal of advanced periodontology & implant dentistry
TI - Antimicrobial effects of nanocurcumin gel on reducing the microbial count of
gingival fluids of implant‒abutment interface: A clinical study
VL - 14
ID - 14609
ER -
TY - JOUR
AB - The aim of this research work was to formulate and evaluate ciprofloxacin
hydrochloride-loaded nanocarriers for treating dental infections and bone
regeneration. Periodontal infection is associated with inflammation, soft tissue
destruction, and bone loss. The objective of the study was to extract β tricalcium
phosphate (β-TCP) from coral beach sand using the hydrothermal conversion method
and load these nanocarriers with ciprofloxacin hydrochloride. The developed drug-
loaded nanocarriers were evaluated for various parameters. In vitro drug-loading
studies showed the highest drug loading of 71% for F1 with a drug: carrier ratio
compared to plain ciprofloxacin hydrochloride gel. β-TCP and nanocarriers were
evaluated for powder characteristics and the results were found to have excellent
and fair flowability. In vitro drug release studies conducted over a period of 5
days confirmed the percentage drug release of 96% at the end of 120 h. Nanocarriers
were found to be effective against S. aureus and E. coli showing statistically
significant antibacterial activity at (* p < 0.05) significant level as compared to
plain ciprofloxacin hydrochloride gel. The particle size of β-TCP and nanocarriers
was found to be 2 µm. Fourier transform infra-red studies showed good compatibility
between the drug and the excipients. Differential scanning calorimetry studies
revealed the amorphous nature of the nanocarriers as evident from the peak shift.
It is obvious from the XRD studies that the phase intensity was reduced, which
demonstrates a decrease in crystallinity. Nanocarriers released the drug in a
controlled manner, hence may prove to be a better option to treat dental caries as
compared to conventional treatments.
AN - rayyan-563559737
AU - Ghazwani, M.
AU - Vasudevan, R.
AU - Kandasamy, G.
AU - Hani, U.
AU - Niharika, G.
AU - Naredla, M.
AU - Devanandan, P.
AU - Puvvada, R. C.
AU - Almehizia, A. A.
AU - Hakami, A. R.
AU - Dhurke, R.
DO - 10.3390/molecules28072914
IS - 7
calcium phosphate
ciprofloxacin
chemistry
dental caries
Escherichia coli
human
LA - English
PY - 2023
SN - 1420-3049
ST - Development and In Vitro Characterization of Antibiotic-Loaded Nanocarriers
for Dental Delivery
T2 - Molecules
TI - Development and In Vitro Characterization of Antibiotic-Loaded Nanocarriers
for Dental Delivery
VL - 28
ID - 13111
ER -
TY - JOUR
AB - Thousands of microorganisms coexist within the human microbiota. However,
certain conditions can predispose the organism to the overgrowth of specific
pathogens that further lead to opportunistic infections. One of the most common
such imbalances in the normal oral flora is the excessive growth of Candida spp,
which produces oral candidiasis. In immunocompromised indi-viduals, this fungal
infection can reach the systemic level and become life-threatening. Hence, prompt
and efficient treatment must be administered. Traditional antifungal agents, such
as poly-enes, azoles, and echinocandins, may often result in severe adverse
effects, regardless of the administration form. Therefore, novel treatments have to
be developed and implemented in clinical prac-tice. In this regard, the present
paper focuses on the newest therapeutic options against oral Candida infections,
reviewing compounds and biomaterials with inherent antifungal properties, improved
materials for dental prostheses and denture adhesives, drug delivery systems, and
combined approaches towards developing the optimum treatment.
AN - rayyan-563559983
AU - Gheorghe, D. C.
AU - Niculescu, A. G.
AU - Bîrcă, A. C.
AU - Grumezescu, A. M.
IS - 6
KW - tooth prosthesis
amphotericin B
anidulafungin
biomaterial
caspofungin
clotrimazole
echinocandin
essential oil
fluconazole
hydrogel
iron oxide
itraconazole
ketoconazole
liposome
metal oxide
micafungin
nanocomposite
nanofiber
nystatin
polycaprolactone
posaconazole
pyrrole derivative
titanium dioxide
vancomycin
voriconazole
antifungal activity
biocompatibility
biodegradability
biofilm
Candida albicans
Candida glabrata
Candida tropicalis
candidiasis
cheilitis
drug release
electrospinning
encapsulation
human
hyposalivation
microemulsion
mouth hygiene
mycosis
nanotechnology
periodontitis
polymerization
review
risk factor
tensile strength
thrush
tissue engineering
LA - English
PY - 2021
SN - 1999-4923
ST - Biomaterials for the prevention of oral candidiasis development
T2 - Pharmaceutics
TI - Biomaterials for the prevention of oral candidiasis development
VL - 13
ID - 13357
ER -
TY - JOUR
AB - White spot lesions (WSLs) are one of the adverse effects of fixed orthodontic
treatments. They are the primary sign of caries, which means inhibiting this
process by antibacterial agents will reverse the procedure. The current study
tested the surface modification of nickel-titanium (NiTi) wires with ZnO
nanoparticles (NPs), as antimicrobial agents. As the morphology of NPs is one of
the most critical factors for their properties, the antibacterial properties of
different morphologies of ZnO nanostructures coated on the NiTi wire were
investigated. For the preparation of ZnO nanostructures, five coating methods,
including chemical vapor deposition (CVD), chemical precipitation method, polymer
composite coating, sol-gel synthesis, and electrospinning process, were used. The
antibacterial activity of NPs was assessed against Streptococcus mutans by the
colony counting method. The obtained results showed that all the samples had
antibacterial effects. The antibacterial properties of ZnO NPs were significantly
improved when the specific surface area of particles increased, by the ZnO
nanocrystals prepared via the CVD coating method.
AN - rayyan-563560054
AU - Gholami, M.
AU - Esmaeilzadeh, M.
AU - Kachoei, Z.
AU - Kachoei, M.
AU - Divband, B.
DO - 10.1155/2021/6397698
KW - orthodontic wire
antibiotic agent
nanocoating
nanocrystal
nickel
nitinol
polymer
titanium
article
chemical vapor deposition
controlled study
electrospinning
morphological trait
morphology
nonhuman
precipitation
sol-gel
surface area
LA - English
PY - 2021
SN - ["2314-6141", "2314-6133"]
ST - Influence of Physical Dimension and Morphological-Dependent Antibacterial
Characteristics of ZnO Nanoparticles Coated on Orthodontic NiTi Wires
TI - Influence of Physical Dimension and Morphological-Dependent Antibacterial
Characteristics of ZnO Nanoparticles Coated on Orthodontic NiTi Wires
VL - 2021
ID - 13428
ER -
TY - JOUR
AB - Background: Enterococcus faecalis, as a major microorganism in
persistent/secondary infections of endodontically treated teeth, is less likely to
be eliminated during endodontic therapy. In this study, the effect of root canal
disinfection and anti-virulence activities of photodynamic inactivation (PDI) of E.
faecalis utilizing reduced graphene oxide-curcumin (rGO-Cur) as a photosensitizing
agent following irradiation with light-emitting diode (LED), as well as
intracellular ROS production were evaluated on ex vivo biofilms of E. faecalis in
comparison with sodium hypochlorite (NaOCl) as the traditional endodontic
irrigation solution. Materials and methods: After formulation and confirmation of
synthesized rGO-Cur using scanning electron microscopy (SEM), Fourier
transformation infrared (FT-IR), UV-Vis spectra, dynamic light scattering (DLS),
and Zeta potential, the minimum biofilm inhibitory concentrations (MBICs) and in
vitro anti-biofilm activity of rGO-Cur, light-emitting diode (LED) at the
wavelength of 435 +/- 20 nm, and rGO-Cur-PDI were determined against 4-week-old
pre-formed biofilms of E. faecalis. After preparation of ex vivo biofilm model in
root canals, the ex-vivo anti-biofilm potential of rGO-Cur, LED, and rGO-Cur-PDI
against E. faecalis were analyzed using the XTT assay and scanning electron
microscopy (SEM) in comparison with NaOCl. The effects of sub-MBIC of rGO-Cur and
NaOCl, sub-lethal dose of LED, and sub-significant inhibitory (SSI) potential of
rGO-Cur-PDI for E. faecalis biofilms on virulence genes (efa, esp, gel, and fsr)
expression of E. faecalis were analyzed using real-time polymerase chain reaction
(qRT-PCR) assay. Intracellular reactive oxygen species (ROS) level was measured in
rGO-Cur-PDI-treated bacterial cells compared to control cells with 2',7'-
dichlorfluorescein-diacetate (DCFH-DA) fluorescent probe. Results: The FTIR, DLS,
Zeta potential, SEM, and UV-Vis spectra analysis indicated the successful synthesis
of rGO-Cur. The MBIC of rGO-Cur was 250 mu g/ml, which inhibited the growth ofE.
faecalis. LED showed insignificant anti-biofilm activity against E. faecalis even
after treating for a long irradiation time (300 s). According to checkerboard
assay, the MBIC value of rGO-Cur-PDI was reduced noticeably compared to the
individual MBIC values of rGO-Cur and LED for E. faecalis. The expression levels of
efa, esp, gel, and fsr genes in pre-formed E. faecalis biofilms were markedly
reduced after rGO-Cur, rGO-Cur-PDI, and NaOCl treatment in comparison with the
control group. Conversely, LED revealed no significant change in the expression of
the virulence genes. The intracellular ROS assay showed a significant increase
(8.3-fold) in rGO-Cur-PDI when compared to the control. Conclusion: Our data
support that rGO-Cur-PDI showed dual inhibitory effects on biofilm formation
ability and virulence activity of E. faecalis with potential clinical applications
for infection control in endodontics.
AN - rayyan-563562591
AU - Ghorbanzadeh, R.
AU - Assadian, H.
AU - Chiniforush, N.
AU - Parker, S.
AU - Pourakbari, B.
AU - Ehsani, B.
AU - Alikhani, M. Y.
AU - Bahador, A.
DO - 10.1016/j.pdpdt.2019.101643
PY - 2020
SN - ["1572-1000", "1873-1597"]
ST - Modulation of virulence in Enterococcus faecalis cells surviving
antimicrobial photodynamic inactivation with reduced graphene oxide-curcumin: An ex
vivo biofilm model
TI - Modulation of virulence in Enterococcus faecalis cells surviving
antimicrobial photodynamic inactivation with reduced graphene oxide-curcumin: An ex
vivo biofilm model
VL - 29
Y2 - 3
ID - 15965
ER -
TY - JOUR
AB - Background: Periodontal diseases are characteristic for the excessive release
of oxidant free-radicals by the host. The aim of the present study was to evaluate
the effcacy of an anti-oxidant-based formula containing propolis and herbs as an
adjunctive therapy to standard non-surgical periodontal treatment (NSPt) when
compared to the domiciliary use of chlorhexidine-based formulae. METHODS: Forty
patients were enrolled in the present study and randomly allocated to either a
control (NSPT plus chlorhexidine gel formula) group or a test (NSPt plus anti-
oxidant gel formula) group. clinical parameters for the assessment of the
periodontal status were evaluated at baseline, one month, and three months after
NSPT, and the salivary antioxidant capacity as well. RESULTS: There were no
signifcant clinical differences between the two groups (P>0.05). However, patients
within the test group (propolis) achieved better results in terms of oxidative
stress reduction (P<0.05). CONCLUSIONS: In the present study, propolis was
comparable to chlorhexidine in the clinical management of gingivitis. Further
studies are needed to investigate its potential as a redox modulator for the oral
microbiome.
AN - rayyan-563560239
AU - Giammarinaro, E.
AU - Marconcini, S.
AU - Genovesi, A.
AU - Poli, G.
AU - Lorenzi, C.
AU - Covani, U.
DO - 10.23736/S0026-4970.18.04143-2
IS - 5
KW - saliva collector
antioxidant
chlorhexidine
ferric ion
ferrous ion
plak gel
propolis
adjuvant therapy
adult
aged
antioxidant assay
apitherapy
article
clinical article
controlled study
decontamination
female
follow up
gingiva bleeding
gingivitis
human
longitudinal study
male
motivation
mouth hygiene
outcome variable
oxidative stress
plaque index
root planing
spectrophotometry
LA - English
PY - 2018
SN - ["1827-174X", "0026-4970"]
SP - 183-188
ST - Propolis as an adjuvant to non-surgical periodontal treatment: A clinical
study with salivary anti-oxidant capacity assessment
T2 - Minerva Stomatol.
TI - Propolis as an adjuvant to non-surgical periodontal treatment: A clinical
study with salivary anti-oxidant capacity assessment
VL - 67
ID - 13613
ER -
TY - JOUR
AB - Physiologically relevant in vitro models of the human host-microbiome
interaction can be a powerful screening tool for antimicrobials and holds great
potential for drug validation and discovery. Furthermore, they can be expected to
have a huge impact on how we interpret toxicity in vitro and will give new
dimensions for risk assessment particularly in the field of medical devices e.g.
dental implants and restorations. In this study, we investigated the oral host-
microbiome interactions by exposing organotypic human gingiva equivalents
(reconstructed gingiva epithelium on gingiva fibroblast populated hydrogel) to
commensal, gingivitis and cariogenic oral biofilms grown from human saliva. The
phenotypical different biofilms contained physiological numbers of bacterial
species, averaging over 70 operational taxonomic units (OTUs), including twenty
differentiating OTUs. Each biofilm type contained typical biomarkers related to its
phenotype. The multilayered epithelium of the gingiva equivalents suprabasally
expressed elafin, a protease inhibitor and antimicrobial protein, which increased
after exposure to all biofilm types. Biofilm exposure increased antimicrobial CCL20
and inflammatory IL-6, CXCL8 and CCL2 secretion from gingiva equivalents. This
inflammatory response was by far greater after commensal biofilm expose than after
pathogenic biofilm exposure. These results indicate immune evasion by pathogenic
oral biofilms compared to commensal oral biofilms and strongly indicates that the
type of host-microbiome interaction needs to be taken into account when
investigating toxicology of medical devices used in dentistry in the future.
AN - rayyan-563560289
AU - Gibbs, S.
AU - Buskermolen, J.
AU - Krom, B.
AU - Janus, M.
AU - Roffel, S.
DO - 10.1016/j.toxlet.2017.07.966
endogenous compound
interleukin 6
interleukin 8
monocyte chemotactic protein 1
tiprelestat
averaging
biofilm
commensal
conference abstract
controlled study
dentistry
epithelium
ex vivo study
fibroblast
gingivitis
human
hydrogel
immune evasion
medical device
microbiome
nonhuman
phenotype
protein expression
saliva
toxicology
LA - English
PY - 2017
SN - 1879-3169
SP - S274
ST - Saliva derived cariogenic and gingivitis biofilms show immune evasion
potential compared to commensal biofilms in a human organotypic gingiva model
T2 - Toxicol. Lett.
TI - Saliva derived cariogenic and gingivitis biofilms show immune evasion
potential compared to commensal biofilms in a human organotypic gingiva model
VL - 280
ID - 13663
ER -
TY - JOUR
AB - A redox dye, methylene blue, was compared with subgingival root surface
debridement and sterile water in the treatment of adult periodontitis. Plaque and
gingival indices, bleeding on probing, and microbiological samples were obtained at
baseline, and at 1, 4, 8 and 12 weeks following treatment. All subjects had matched
pockets in each of the 4 quadrants, of 5 mm or more. One treatment consisted of
0.1% methylene blue gel irrigated professionally at 0, 1 and 4 weeks, and by
subjects at days in between up to 4 weeks, at chosen sites within a randomly
selected quadrant (split-mouth design). A 2nd treatment was sterile water
irrigation as above. A 3rd quadrant received subgingival debridement, and sites in
the 4th received methylene blue incorporated into a slow-release device of a
biodegradable collagen alginate vicryl composite. All sites showed improvements in
clinical and microbiological parameters. However, no statistically significant
differences between treatment types were found for clinical measurements. Although
plaque index tended to increase after week 1, gingival index was reduced, as was
the papilla bleeding index. Probing depth reductions were approximately 1.2 mm for
all treatments. Microbiological variables showed an increase in cocci and a
decrease in motile organisms for all groups, the latter reaching statistical
significance for subgingival debridement. The reductions in spirochaetes were
significant for subgingival debridement and methylene blue by slow-release. Culture
demonstrated an increase in the aerobe:anaerobe ratio for all groups, which was
statistically significant initially (weeks 1 and 4) for subgingival debridement.
Methylene blue was also effective statistically in improving this ratio, both by
irrigation and slow-release (week 4). Methylene blue also significantly reduced the
numbers of black-pigmented anaerobes during the trial period, both by irrigation
and slow-release, which sterile water and subgingival debridement failed to do. No
serious adverse experiences were seen, however, significantly greater morbidity was
associated with subgingival debridement. These results clearly demonstrate that in
altering the microflora to one that is more compatible with periodontal health,
methylene blue treatment is comparable, or even better, than the currently standard
treatment of subgingival debridement, and is better tolerated.
AN - rayyan-563561076
AU - Gibson, M. T.
AU - Mangat, D.
AU - Gagliano, G.
AU - Wilson, M.
AU - Fletcher, J.
AU - Bulman, J.
AU - Newman, H. N.
IS - 10
KW - methylene blue
oxidizing agent
adult
article
bacterial count
bacterium
chronic disease
clinical trial
comparative study
controlled study
drug effect
drug screening
female
gel
human
lavage
male
microbiology
middle aged
periodontics
periodontitis
spirochete
tooth plaque
LA - English
PY - 1994
SN - 0303-6979
SP - 690-700
ST - Evaluation of the efficacy of a redox agent in the treatment of chronic
periodontitis
TI - Evaluation of the efficacy of a redox agent in the treatment of chronic
periodontitis
VL - 21
ID - 14450
ER -
TY - JOUR
AN - rayyan-563561872
AU - Gill, J. S.
AU - Bharti, V.
AU - Gupta, H.
AU - Gill, S.
DO - 10.4317/jced.3.e424
IS - 5
PY - 2011
SP - e424-e429
ST - Non-surgical management of chronic periodontitis with two local drug delivery
agents- A comparative study
T2 - Journal of Clinical and Experimental Dentistry
TI - Non-surgical management of chronic periodontitis with two local drug delivery
agents- A comparative study
84865085514&doi=10.4317%2fjced.3.e424&partnerID=40&md5=bdf9d0a67f12a4745237969c1d63
c26e
VL - 3
ID - 15246
ER -
TY - JOUR
AB - OBJECTIVES The aim of this experimental in vi-vo research was to evaluate the
efficacy of a new periodontal, top-ic and natural gel (mainly made by flowers and
fruits sodium bicar-bonate and hyaluronic acid) as a substitute of Chlorexidine
opera-tion, without the well-known side effects connected to her. The pri-mary
hypothesis is to test that the new natural gel can reduce sig-nificantly Bleeding
on Probing in-dex, Plaque index and Pocket depth index after non-surgical
periodontal theraphy, if compared to Chlorexidine and a control group. MATERIALS
AND METHODS 30 patients have been selected according to the following inclu-sion
criteria: 18-70 years old, periodontal pockets greater then 3 mm, good compliance
and col-laboration. The collected indexes were: Full Mouth Plaque Score, Full Mouth
Bleeding Score and Probing Pocket Depth. 30 pa-tients have been divided into 3
groups: at T0 a collection of the indexes and a professional dental hygiene have
been conducted for each group. At T1 group C patients (control group) had a Scaling
and Roots planning treatment. Group A patients (Chlorexidine group) had both an SRP
treatment and the administration of periodontal gel Curasept Chlorex-idine 1%
(Curasept, Saronno-Varese, Italy) into pockets. Group B patients (natural gel
group) had both an SRP treatment and the administration of periodontal gel Klirich
Pro (Itena Clinical, Vil-lepinte, France) into pockets. Patients of groups A and B
have been instructed to use their re-spective gel (Curasept gel 1% for group A and
Klirich Home gel (Ite-na Clinical, Villepinte, France) for group B) in the
following 10 days after the treatment. After 40 days (T2) a check has been carried
out, in which we have collected indexes and eventually gel of group A and B have
been admin-istered. Finally, 3 months after the check, indexes have been collected
again and a professional dental hygiene has been conducted. RESULTS The Full Mouth
Plaque Score reduction of each group is: group A 36%; Group B 41.3%; group C 12.9%.
The greater reduction of FMPS is in group B, followed by group A. Group C shows a
significant lower reduction of the index. Taking into consideration the Full Mouth
Bleeding Score reduction: group A 34.2%; Group B 51%; Group C 19%. Even then, group
A and B have a significant lower reduction if compared with group C. The median
value of Probing Pocket Depth shows a reduction of 1.1 mm in group A and 0.9 in
group B. Indeed, group C shows a reduction of 0.4 mm. CONCLUSIONS Statistical
analysis demonstrates that the use of the natural gel, combined with non-surgical
peri-odontal therapy, has a statistically significant role (P <0.05) in the in-
dexes reduction. Within the limits of this research, because of the limited number
of patients and the follow-up, we can conclude that this natural gel shows
comparable results to the group treated with Chlorexidine gel, without showing side
effect of pigmentation and dysgeusia. CLINICAL SIGNIFICANCE Results gained from
this experimental study underline the grow-ing trend of using natural gel as an
adjuvant of non-surgical periodontal therapy. Further studies should be conducted
in order to confirm efficacy (taking into account FMPS, FMBS, PPD indexes) and to
exclude potential side effects.
AN - rayyan-563560094
AU - Giordano, F.
AU - Esposito, F.
AU - Butera, A.
DO - 10.19256/d.cadmos.07.2020.08
IS - 7
KW - bicarbonate
chlorhexidine
dental material
gel
hyaluronic acid
periodontal gel
unclassified drug
article
bleeding on probing index
clinical article
clinical evaluation
controlled study
flower
fruit
full mouth bleeding score
full mouth plaque score
human
in vivo study
periodontal pocket
plaque index
pocket depth index
LA - Italian
PY - 2020
SN - 0011-8524
SP - 462-467
ST - Evaluation of the efficacy of a new natural gel in non-surgical periodontal
therapy
T2 - Valutazione dell’efficacia di un nuovo gel naturale nella terapia parodontale
non chirurgica
TI - Evaluation of the efficacy of a new natural gel in non-surgical periodontal
therapy
VL - 88
ID - 13468
ER -
TY - JOUR
AB - Periodontal diseases are a group of disorders characterized by an
inflammatory reaction of periodontium induced by bacterial challenge leading to
gingival inflammation, periodontal tissue destruction and alveolar bone loss. The
use of naturally derived agents is becoming more common. Many of these agents
contain a mixture of active pharmaceutical ingredients combined based on their
additive or synergistic properties. The aim of the present study is to review the
literature about the use of herbal drugs and other natural products in the
treatment of periodontal diseases and their antiinflammatory properties. A web
search through Pubmed and hand search including several dental journals was
performed up to December 2015, using the keywords (herbal anti-inflammatory agents
OR herbal antioxidant) AND (periodontitis OR periodontal disease OR periodontosis).
Three topics were investigated: 1) major herbal agents and their biological
properties compared with chlorhexidine, the most used chemical agent in periodontal
therapy 2) toothpaste, gel and mouthrinse formulations as principal vehicles for
herbal products 3) In vitro and in vivo studies to test their ability in reducing
periodontal inflammation. The search revealed numerous papers investigating herbal
products in the treatment of periodontal diseases. As bacteria develop resistance
to classical antibiotics, studies aim to formulate alternative options for
controlling periodontal pathogens using plants with anti-inflammatory properties.
AN - rayyan-563560388
AU - Giraudi, M.
AU - Romano, F.
AU - Aimetti, M.
DO - 10.2174/221270380201160517185849
IS - 1
chlorhexidine
essential oil
herbaceous agent
interleukin 1beta
interleukin 6
interleukin 8
kampos
lipopolysaccharide
mouthwash
plant extract
prostaglandin E2
septilin
toothpaste
triphala
unclassified drug
xiaochaihu tang
alveolar bone loss
article
cytokine production
gingivitis
human
Lippia sidoides
Lotus (genus)
medicinal plant
nonhuman
Panax notoginseng
periodontics
priority journal
protein expression
Rehmannia glutinosa
root cortex
Salvadora persica
tissue injury
tooth plaque
LA - English
PY - 2015
SN - ["2212-7046", "2212-7038"]
SP - 27-37
ST - An update on herbal anti-inflammatory agents in periodontal therapy
T2 - Clin. Anti-Inflamm. Anti-Allergy Drugs
TI - An update on herbal anti-inflammatory agents in periodontal therapy
VL - 2
ID - 13762
ER -
TY - JOUR
AB - Periodontal inflammation is one of the most common chronic inflammatory
conditions in humans. Despite recent advances in identifying and characterizing
oral microbiota dysbiosis in the pathogenesis of gum disease, just how host factors
maintain a healthy homeostatic oral microbial community or prevent the development
of a pathogenic oral microbiota remains poorly understood. An important determinant
of microbiota fate is local antimicrobial proteins. Here, we report that
chemoattractant protein chemerin, which we recently identified as a potent
endogenous antimicrobial agent in body barriers such as the skin, is present in the
oral cavity under homeostatic and inflammatory conditions. Chemerin and a chemerin-
derived antimicrobial peptide are bactericidal against select bacteria
strategically positioned in dental biofilm. Gingival crevicular samples from
patients with gingivitis but not periodontitis contain abundant bioactive chemerin
capable of inducing CMKLR1-dependent leukocyte migration. Gingipains secreted by
the periodontopathogen P. gingivalis inactivate chemerin. Together, these data
suggest that as an antimicrobial agent and leukocyte chemoattractant, chemerin
likely contributes to antimicrobial immune defense in the oral cavity.
AN - rayyan-563560304
AU - Godlewska, U.
AU - Brzoza, P.
AU - Sroka, A.
AU - Majewski, P.
AU - Jentsch, H.
AU - Eckert, M.
AU - Eick, S.
AU - Potempa, J.
AU - Zabel, B. A.
AU - Cichy, J.
DO - 10.3389/fimmu.2017.00353
KW - chemerin
article
broth dilution
chemotaxis assay
controlled study
denaturing high performance liquid chromatography
enzyme activity
gene amplification
gingivitis
immunity
nonhuman
LA - English
PY - 2017
SN - 1664-3224
ST - Antimicrobial and attractant roles for chemerin in the oral cavity during
inflammatory gum disease
TI - Antimicrobial and attractant roles for chemerin in the oral cavity during
inflammatory gum disease
VL - 8
ID - 13678
ER -
TY - JOUR
AB - OBJECTIVE: The objective of this study was to evaluate the microbiological
profile of root canals indicated for endodontic retreatment due to secondary
endodontic infections evidenced by the presence of chronic apical periodontitis
(G1) or for prosthetic reasons, without clinical and radiographic signs of
endodontic reinfection (G2). METHODS: Microbiological samples were collected from
thirty teeth (N=30) out of which 15 were indicated for retreatment due to the
presence of chronic apical periodontitis (G1) and 15 were indicated exclusively for
prosthetic reasons (G2). Samples were collected from root canals before (S1), after
chemomechanical preparation (S2), and after 30 days of intracanal medication
composed of calcium hydroxide and 2% chlorhexidine gel (S3). The molecular analysis
was performed using Nested-PCR for the detection of 17 bacterial species. The
efficacy of each stage of the retreatment in reducing the microbial load was
verified by counting colony-forming units (CFU). The statistical analysis
considered a significance level of 5%. RESULTS: The results showed that bacteria
were detected in 100% of the cases in S1, in both groups, by Nested PCR. The most
frequently found species in S1 in both groups were Enterococcus faecalis,
Fusobacterium nucleatum, Porphyromonas gingivalis, Aggregatibacter
actinomycetemcomitans, and Parvimonas micra. The microbial load of G1 was higher
than G2 in the initial samples (S1). Endodontic retreatment was effective in
reducing the microbial load in G1 and G2. Statistically significant associations
were found between specific bacteria and clinical signs and symptoms. CONCLUSION:
It was concluded that the microbial community present in the root canal of teeth
indicated for endodontic retreatment is mixed and heterogeneous. G1 and G2 differ
in the number of species per case and microbial load. CLINICAL RELEVANCE:
Endodontic retreatment was effective in reducing the microbial load. Statistically
significant associations were found between specific bacteria and clinical signs
and symptoms.
AN - rayyan-563559720
AU - Godoi-Jr, E. P.
AU - Bronzato, J. D.
AU - Francisco, P. A.
AU - Bícego-Pereira, E. C.
AU - Lopes, E. M.
AU - Passini, M. R. Z.
AU - Marciano, M. A.
DO - 10.1007/s00784-023-04947-x
IS - 5
calcium hydroxide
chlorhexidine
dental pulp cavity
human
microbiology
retreatment
LA - English
PY - 2023
SN - 1436-3771
SP - 2049-2064
ST - Microbiological profile of root canals indicated for endodontic retreatment
due to secondary endodontic infections or for prosthetic reasons
TI - Microbiological profile of root canals indicated for endodontic retreatment
due to secondary endodontic infections or for prosthetic reasons
VL - 27
ID - 13094
ER -
TY - JOUR
AB - The objective of this study was to compare efficacy of 1% Alendronate gel and
Tetracycline fibers as an adjunct to scaling and root planning (SRP). A total of 30
patients with diagnosis of chronic periodontitis (60 localized periodontitis sites)
in an age group of 20-55 years were selected. None of these patients had received
any non-surgical or surgical periodontal therapy and had periodontal pockets
measuring 4-7 mm clinically. Two sites in any quadrants after randomization were
selected in each patient. Navy Plaque index (Grossaman and Fedi) and Gingival
bleeding index (GI) (Loe and Sillness), Clinical probing depth (PD) and Clinical
attachment level (CAL) were measured at baseline 1,3 and 6 months. Random
allocation of test site (treated with 1% Alendronate Gel) and control site (treated
with Tetracycline fibers). The results revealed that there was significant
improvement in all clinical parameters from baseline to 6 months and test group
presented with better results than control group however the difference was not
statistically significant.
AN - rayyan-563560366
AU - Goel, A.
AU - Arora, S. A.
AU - Chhina, S.
DO - 10.13040/IJPSR.0975-8232.7(10).4134-39
IS - 10
tetracycline
adult
article
clinical article
Clinical probing depth
controlled study
dental scaling
drug efficacy
human
Navy Plaque index
root planing
LA - English
PY - 2016
SN - ["0975-8232", "2320-5148"]
SP - 4134-4139
ST - Comparative efficacy of 1% alendronate gel and tetracycline fibers as an
adjunct to scaling and root planing: A randomized control clinical trial
TI - Comparative efficacy of 1% alendronate gel and tetracycline fibers as an
adjunct to scaling and root planing: A randomized control clinical trial
VL - 7
ID - 13740
ER -
TY - JOUR
AB - The work describes the biocompatibility and biodegradation studies of anionic
collagen membranes casted form collagen gels collagen, that were selective
hydrolyzed at the carboxyamide groups, as a function of the degree of cross-links
induced by glutaraldehyde. Independently from the degree of cross-links, all
membranes studied were characterized by a similar inflammatory response, inversely
dependent on glutaraldehyde reaction time, that decreased from the time of the
implant. Cell alterations, mineralization or contact necrosis were not observed in
any of the membranes studied. Rates for membrane tissue biodegradation were
directly related to glutaraldehyde reaction time, and ranged from 30 to periods
longer than 60 days, associated with good biocompatibility. Although other
properties must be considered, their use in the treatment of periodontal diseases,
the biological behavior observed with the 8 h GA cross-linked membrane suggests
that, anionic collagen membrane described in this work may be of potential use, not
only in association with guided tissue regeneration technique for periodontal
tissue reconstruction, but also in other collagen biomaterial applications where
controlled biodegradability is required.
AN - rayyan-563561014
AU - Goissis, G.
AU - Marcantonio Jr, E.
AU - Marcantônio, R. A. C.
AU - Lia, R. C. C.
AU - Cancian, D. C. J.
AU - De Carvalho, W. M.
DO - 10.1016/S0142-9612(97)00198-1
IS - 1
KW - anion
collagen
collagen gel
glutaraldehyde
article
biocompatibility
biodegradation
cross linking
hydrolysis
implant
inflammation
membrane
mineralization
necrosis
periodontal disease
periodontics
priority journal
reaction time
LA - English
PY - 1999
SN - 0142-9612
SP - 27-34
ST - Biocompatibility studies of anionic collagen membranes with different degree
of glutaraldehyde cross-linking
T2 - Biomaterials
TI - Biocompatibility studies of anionic collagen membranes with different degree
of glutaraldehyde cross-linking
VL - 20
ID - 14388
ER -
TY - JOUR
AB - Tetracyclines are now recognized to have non-antimicrobial properties with
therapeutic potential--for example, these agents can inhibit pathologic
collagenolysis by blocking mammalian collagenases and other matrix-degrading
metalloproteinases. In the current study, adult human subjects with moderate
chronic periodontitis were administered specially formulated capsules of
doxycycline, containing lower-than-usual amounts of this semi-synthetic
tetracycline, on a daily basis for 2 weeks prior to a full-thickness flap
procedure; control subjects were administered placebo capsules. The gingiva excised
during this surgical procedure were extracted, the extracts partially purified and
analyzed for collagenase activity using [3H-methyl] collagen as substrate and the
techniques of SDS-PAGE/fluorography or liquid scintillation spectrometry. In the
absence of any drug pre-treatment, or after a 2-wk regimen of placebo capsules, the
gingival extracts exhibited pathologically-excessive mammalian collagenase
activity. The 2-wk regimen of low-dose doxycycline capsules reduced this activity
by approximately 60-80% (p less than 0.05 and less than 0.01, respectively); in
vitro exposure of the gingival extract to doxycycline also inhibited its
collagenase activity. Collagenase activity in the crevicular fluid of periodontal
pockets of an additional group of subjects was also significantly reduced, as was
the severity of inflammation at the same gingival sites. The results suggest that a
regimen of low-dose doxycycline capsules may provide a safe (other studies indicate
that this regimen may not induce tetracycline resistance in the subgingival plaque)
and effective adjunct to instrumentation therapy in the management of pathologic
collagenolysis in the periodontal patient. However, further studies are necessary
to confirm this hypothesis.
AN - rayyan-563561437
AU - Golub, L. M.
AU - Ciancio, S.
AU - Ramamamurthy, N. S.
AU - Leung, M.
AU - McNamara, T. F.
DO - 10.1111/j.1600-0765.1990.tb00923.x
IS - 6
KW - Adult
Doxycycline/*administration & dosage/pharmacology
Gingiva/*enzymology
Gingival Crevicular Fluid/*enzymology
Humans
Microbial Collagenase/*antagonists & inhibitors
Middle Aged
Periodontitis/drug therapy
LA - eng
N1 - Dept. of Oral Biology and Pathology, School of Dental Medicine, S.U.N.Y.,
Stony Brook.
PY - 1990
SN - 0022-3484 (Print)
SP - 321-30
ST - Low-dose doxycycline therapy: effect on gingival and crevicular fluid
collagenase activity in humans
TI - Low-dose doxycycline therapy: effect on gingival and crevicular fluid
VL - 25
Y2 - 11
ID - 14811
ER -
TY - JOUR
AN - rayyan-563562149
AU - Golub, L. M.
AU - Ciancio, S.
AU - Ramamurthy, N. S.
AU - Leung, M.
DO - 10.1111/j.1600-0765.1990.tb00923.x
IS - 6
PY - 1990
SP - 321-330
ST - Low‐dose doxycycline therapy: Effect on gingival and crevicular fluid
TI - Low‐dose doxycycline therapy: Effect on gingival and crevicular fluid
0025686083&doi=10.1111%2fj.1600-
0765.1990.tb00923.x&partnerID=40&md5=7d26b7b6cf4e89f8068b158d147ecd84
VL - 25
ID - 15523
ER -
TY - JOUR
AB - Diabetes increases gingival collagenase activity, an effect that may be
mediated by endogenous tissue changes and exacerbated by an overgrowth of Gram-
negative organisms in the gingival crevice (see Ramamurthy & Golub 1983, McNamara
et al. 1982). In an attempt to reverse this collagenolytic abnormality, we
administered an appropriate antibiotic, minocycline (a semisynthetic tetracycline),
to diabetic rats and humans. Adult male conventional or germfree rats were made
diabetic with streptozotocin, and half these animals were administered minocycline
(20 mg per day) by tube feeding for 3-4 weeks prior to sacrifice. The buccal
gingiva, entire skins, and mandibles were dissected and tested for collagenolytic
enzyme activity, collagen content, and alveolar bone loss, respectively. In a
preliminary study, minocycline (200 mg per day) was administered for 7 days to an
insulin-dependent diabetic adolescent human and an adult non-diabetic human; the
twin brother of the diabetic was treated with penicillin. Gingival fluid
collagenase activity was measured (using [3H-methyl] collagen as substrate in a new
microassay) in 8 periodontal pockets in each subject before and after antibiotic
therapy. Examination of collagenase digestion products by SDS-polyacrylamide gel
electrophoresis and fluorography was also carried out. In rats, minocylcine
treatment: (1) suppressed the abnormally elevated collagenolytic enzyme activity in
gingiva of diabetic rats, even under germfree conditions: (2) inhibited PMN
leukocyte collagenase activity in vitro, an effect that was reversed by the
addition of calcium ions (penicillin-streptomycin had no effect on the activity of
this enzyme); and (3) retarded the abnormal loss of skin collagen and alveolar bone
in diabetic rats. In a preliminary study on humans, minocycline therapy reduced the
collagenase activity of gingival crevicular fluid, an effect not produced by
penicillin. Our data suggests that (1) tetracycline therapy inhibits tissue
collagenolytic enzyme activity by a mechanism at least in part unrelated to its
antibacterial efficacy, and (2) this mechanism may provide a new therapeutic
approach for suppressing excessive collagen resorption which occurs during
periodontal disease and which can occur during other pathologic conditions.
AN - rayyan-563561187
AU - Golub, L. M.
AU - Lee, H. M.
AU - Lehrer, G.
IS - 5
KW - collagen h 3
collagenase
minocycline
penicillin G
streptozocin
unclassified drug
animal experiment
animal model
article
collagen degradation
diabetes mellitus
endocrine system
gingiva
mouth
nonhuman
rat
minocin
LA - English
PY - 1983
SN - 0022-3484
SP - 516-526
ST - Minocycline reduces gingival collagenolytic activity during diabetes.
Preliminary observations and a proposed new mechanism of action
TI - Minocycline reduces gingival collagenolytic activity during diabetes.
VL - 18
ID - 14561
ER -
TY - JOUR
AN - rayyan-563562121
AU - Golub, L. M.
AU - Lee, H. M.
AU - Lehrer, G.
AU - Nemiroff, A.
AU - Kaplan, R.
DO - 10.1111/j.1600-0765.1983.tb00388.x
IS - 5
PY - 1983
SP - 516-526
ST - Minocycline reduces gingival collagenolytic activity during diabetes:
TI - Minocycline reduces gingival collagenolytic activity during diabetes:
0021029655&doi=10.1111%2fj.1600-
0765.1983.tb00388.x&partnerID=40&md5=f92069fc8b81cb1543aa4221fa8de186
VL - 18
ID - 15495
ER -
TY - JOUR
AB - We previously reported that low-dose doxycycline (DOXY) therapy reduces host-
derived collagenase activity in gingival tissue of adult periodontitis (AP)
patients. However, it was not clear whether this in vivo effect was direct or
indirect. In the present study, inflamed human gingival tissue, obtained from AP
patients during periodontal surgery, was extracted and the extracts partially
purified by (NH4)2SO4 precipitation. The extracts were then analyzed for
collagenase activity using SDS-PAGE/fluorography/laser densitometry, and for
gelatinase activity using type I gelatin zymography as well as a new quantitative
assay using biotinylated type I gelatin as substrate. DOXY was added to the
incubation mixture at a final concentration of 0-1000 microM. The concentration of
DOXY required to inhibit 50% of the gingival tissue collagenase (IC50) was found to
be 16-18 microM in the presence or absence of 1.2 mM APMA (an optimal
organomercurial activator of latent procollagenases); this IC50 for DOXY was
similar to that exhibited for collagenase or matrix metalloproteinase (MMP)-8 from
polymorphonuclear leukocytes (PMNs) and from gingival crevicular fluid (GCF) of AP
patients. Of interest, Porphyromonas gingivalis collagenase was also inhibited by
similar DOXY levels (IC50 = 15 microM), however the collagenase activity observed
in the gingival tissue extracts was found to be of mammalian not bacterial origin
based on the production of the specific alpha A (3/4) and alpha B (1/4) collagen
degradation fragments. In contrast, the inhibition of collagenase purified from
culture media of human gingival fibroblasts (MMP-1) required much greater DOXY
levels (IC50 = 280 microM). The predominant molecular forms of gelatinolytic
activity presented in the AP patients gingival tissue extracts were found to
closely correspond to the 92 kD PMN-type gelatinase (MMP-9) although small
quantities of 72 kD fibroblast-type gelatinase (MMP-2), and some other low
molecular weight gelatinases, were also detected. The IC50 of DOXY versus gingival
tissue gelatinolytic activity was estimated at 30-50 microM measure using either
type I gelatin zymography or the biotinylated type I gelatin assay. We conclude
that MMPS in inflamed gingival tissue of AP patients, like those in GCF, originate
primarily from infiltrating PMNs rather than resident gingival cells (fibroblasts
and epithelial cells) or monocyte/macrophages, and that their pathologically-
elevated tissue-degrading activities can be directly inhibited by pharmacologic
levels of doxycycline.
AN - rayyan-563561073
AU - Golub, L. M.
AU - Sorsa, T.
AU - Lee, H. M.
AU - Ciancio, S.
AU - Sorbi, D.
AU - Gruber, B.
AU - Salo, T.
AU - Konttinen, Y. T.
IS - 2
KW - 4 aminophenylmercuriacetate
4-aminophenylmercuriacetate
collagenase
doxycycline
drug derivative
gelatinase
interstitial collagenase
adult
article
cell culture
drug antagonism
enzymology
female
fibroblast
gingiva
gingivitis
human
male
neutrophil
periodontitis
LA - English
PY - 1995
SN - 0303-6979
SP - 100-109
ST - Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human
adult periodontitis gingiva
TI - Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human
adult periodontitis gingiva
VL - 22
ID - 14447
ER -
TY - JOUR
AB - Introduction: This clinical study was conducted to compare the efficacy of
chemomechanical preparation with 2.5% sodium hypochlorite (NaOCl) and 2%
chlorhexidine (CHX) gel on eliminating oral bacterial lipopolysaccharide (LPS) in
teeth with pulp necrosis and apical periodontitis. Methods: Fifty-four root canals
were selected. Samples were collect before (s1) and after chemomechanical
preparation (s2). Teeth were randomly divided into groups: GI, 2.5% NaOCl (n = 27)
and GII, CHX gel (n = 27). Limulus amebocyte lysate assay was used to quantify
endotoxins. Results: Endotoxin was present in 100% of the samples investigated,
with a median value of 272 endotoxin units (EU)/mL (GI) and of 152.46 EU/mL (GII).
As a result of chemomechanical preparation, LPS content was reduced to a median
value of 86 EU/mL (GI) and 85 EU/mL (GII). Higher percentage value of endotoxin
reduction was found in GI (P < .05). Conclusions: The 2.5% NaOCl and 2% CHX gel
were not effective in eliminating endotoxin from the primarily infected root
canals.
AN - rayyan-563560665
AU - Vianna, M. E.
DO - 10.1016/j.joen.2009.06.011
IS - 10
chlorhexidine
chromogenic substrate
diagnostic agent
endotoxin
hypochlorite sodium
lipopolysaccharide
adolescent
adult
article
clinical trial
comparative study
controlled study
drug effect
endodontics
human
methodology
microbiology
middle aged
tooth pulp
tooth pulp disease
treatment outcome
LA - English
PY - 2009
SN - 0099-2399
SP - 1350-1353
ST - Comparison of 2.5% Sodium Hypochlorite and 2% Chlorhexidine Gel on Oral
Bacterial Lipopolysaccharide Reduction from Primarily Infected Root Canals
T2 - J. Endod.
TI - Comparison of 2.5% Sodium Hypochlorite and 2% Chlorhexidine Gel on Oral
Bacterial Lipopolysaccharide Reduction from Primarily Infected Root Canals
VL - 35
ID - 14039
ER -
TY - JOUR
AB - The aim of this study was to investigate the antimicrobial activity of
calcium hydroxide (Ca(OH)(2)) combined with 2% chlorhexidine gluconate (CHX) gel
against endodontic pathogens and to compare the results with the ones achieved by
Ca(OH)(2) mixed with sterile water and by CHX gel alone. Two methods were used: the
agar diffusion test and the direct contact test. Ca(OH)(2) + 2% CHX gel produced
inhibitory zones ranging from 2.84 to 6.5 mm, and required from 30 seconds to 6
hours to eliminate all tested microorganisms. However, 2% CHX gel showed the
largest microbial growth zones from 4.33 to 21.67 mm, and required I minute or less
to inhibit all tested microorganisms. A paste of Ca(OH), plus sterile water
inhibited only the microorganisms with which it was in direct contact and required
from 30 seconds to 24 hours to kill all tested microorganisms. In conclusion, 2%
CHX gel + Ca(OH)(2) showed better antimicrobial activity than Ca(OH)(2) manipulated
with sterile water.
AN - rayyan-563562426
AU - Gomes, Bpfd
AU - Vianna, M. E.
AU - Sena, N. T.
AU - Zaia, A. A.
AU - Filho, F. J. D.
DO - 10.1016/j.tripleo.2006.04.04.010
IS - 4
PY - 2006
SN - ["1079-2104", "1528-395X"]
SP - 544-550
ST - In vitro evaluation of the antimicrobial activity of calcium hydroxide
combined with chlorhexidine gel used as intracanal medicament
TI - In vitro evaluation of the antimicrobial activity of calcium hydroxide
combined with chlorhexidine gel used as intracanal medicament
VL - 102
Y2 - 10
ID - 15800
ER -
TY - JOUR
AB - METHODS: Apical periodontitis was induced in 20 upper and lower premolars of
2 dogs. After biomechanical preparation, enlargement to a #60 file, and
disinfection with a triantibiotic paste for 28 days, the roots were randomly
assigned to 4 treatment groups: blood clot (BC), BC + PRP gel, BC + BMA gel, and BC
+ BMA/PRP gel. Negative controls were also included. After a 3-month follow-up
period, the animals were killed. INTRODUCTION: The aim of this study was to
investigate the capacity of endodontic regenerative procedures combining an induced
blood clot, platelet-rich plasma (PRP), and bone marrow aspirate (BMA) to
regenerate dental pulp in canine closed-apex necrotic teeth. RESULTS: Histologic
analysis showed the presence of newly formed vital tissues (connective, cement-
like, and bone-like tissue) in 23 of the 32 treated roots (71.87%). There was no
statistically significant difference between the treatment groups. CONCLUSIONS: New
vital tissues were formed and characterized as connective, cementum-like, or bone-
like, but not as pulp-like tissue; PRP and/or BMA did not improve the tissue
ingrowth.
AN - rayyan-563560465
AU - Gomes-Filho, J. E.
AU - Duarte, P. C.
AU - Ervolino, E.
AU - Mogami Bomfim, S. R.
AU - Xavier Abimussi, C. J.
AU - Mota da Silva Santos, L.
AU - Lodi, C. S.
AU - Penha De Oliveira, S. H.
AU - Dezan, E.
AU - Cintra, L. T.
DO - 10.1016/j.joen.2013.08.023
IS - 12
ciprofloxacin
drug combination
metronidazole
minocycline
thrombin
angiogenesis
animal
blood clotting
bone
bone marrow cell
tooth cementum
comparative study
connective tissue
tooth pulp disease
dog
endodontics
fibroblast
male
pathology
physiology
premolar tooth
procedures
randomization
regeneration
tissue engineering
tooth pulp
LA - English
PY - 2013
SN - 1878-3554
SP - 1549-1556
ST - Histologic characterization of engineered tissues in the canal space of
closed-apex teeth with apical periodontitis
T2 - J Endod
TI - Histologic characterization of engineered tissues in the canal space of
closed-apex teeth with apical periodontitis
VL - 39
ID - 13839
ER -
TY - JOUR
AB - Background: The present study aims to evaluate and compare the efficacy of
locally delivered 1% melatonin gel as an adjunct to non-surgical periodontal
therapy (NSPT) in treatment of intrabony defect in Stage III periodontitis,
clinically, and radiographically using cone-beam computed tomography (CBCT).
Methods: This split-mouth clinical trial randomly allotted 44 bilateral intrabony
defect (in 22 patients) into two groups where Group I was treated with NSPT with
locally delivered placebo gel while Group II was treated with NSPT with 1%
melatonin gel. The intrabony defect fill measured from cemento-enamel junction
(CEJ)-base of the defect (BD), and the difference in the measurement values of CEJ‒
BD from baseline to 6 months denoting the bone fill and bone volume evaluated at 6
months using CBCT were the primary outcome measures. Secondary outcome measures
were change in probing depth (PD), clinical attachment level (CAL), plaque index,
and modified sulcus bleeding index recorded at baseline, 3 months, and 6 months.
Results: Both the study groups showed improvements in assessed parameters, however,
a significant gain in intrabony defect fill was observed in Group II (1.46 ± 0.58)
as compared with Group I (0.50 ± 0.38) and change in bone volume for Group I was
21.4645 ± 8.8980 mm3 and for Group II was 51.8418 ± 30.2329 mm3 with P < 0.0001.The
mean reduction in PD and gain in CAL was 3.90 ± 0.78 and 2.94 ± 0.80 in Group II
and in Group I it was 3.23 ± 0.90 and 1.96 ± 0.80 (P < 0.0001). Conclusion: The use
of 1% melatonin gel as an adjunct to NSPT is more beneficial in achieving better
clinical and radiographic outcome at 6 months which indicates that adjunct use of
melatonin gel to NSPT as a local drug delivery is preferred when compared with NSPT
and placebo gel alone.
AN - rayyan-563559783
AU - Gonde, N. P.
AU - Rathod, S. R.
AU - Kolte, A. P.
DO - 10.1002/JPER.21-0515
IS - 12
KW - CTRI/2019/03/01806
acrylic occlusal stent
cannula
stent
syringe
ultrasonic scaler
gel
melatonin
placebo
propylene glycol
adult
article
bone volume
clinical article
controlled study
drug efficacy
follow up
human
intrabony defect
intraoperative period
jaw disease
jaw malformation
mandible
maxilla
mouth hygiene
non-surgical periodontal therapy
outcome assessment
periodontitis
plaque index
root planing
sulcus bleeding index
SPSS
LA - English
PY - 2022
SN - 0022-3492
SP - 1878-1888
ST - Comparative evaluation of 1% melatonin gel in the treatment of intrabony
defect: A randomized controlled clinical trial
TI - Comparative evaluation of 1% melatonin gel in the treatment of intrabony
defect: A randomized controlled clinical trial
VL - 93
ID - 13157
ER -
TY - JOUR
AB - AIM: The present study was conducted to compare effects of acemannan and
formocresol as pulp-dressing agents clinically and radiographically in primary
teeth. MATERIALS AND METHODS: Aloe vera gel high molecular weight fractions (AHM)
containing native ingredients of polysaccharide (acemannan) and glycoprotein
(verectin) were obtained by using the patented hyper dry system after washing out
coloured materials with running water from Aloe vera gel slurry. Thirty healthy
children aged from four to eight years, they were selected from patients attending
outpatient clinic of Pediatric Dentistry department. Each child had at least
bilateral deep carious lower primary molar indicated for pulpotomy. Pulpotomy was
done in both groups; where group I treated by AHM, acemannan, as a dressing agent
while formocresol used as a dressing agent in group II. The study cases were
recalled after three, six, nine and twelve months for clinical and radiographic
evaluation. RESULTS: The overall clinical success rate of acemannan group was
96.5%, while formocresol group was 89.6%. The two groups were clinically successful
with no statistically significant difference between them (p = 0.148). The
radiographic success rate of acemannan group was 93.1%, while for formocresol group
was 86.2%. There was no statistically significant difference between the two groups
(p = 0.385).CONCLUSION: The acemannan showed higher clinical and radiographic
success rate compared to formocresol as a pulpulpotomy agent in molars. It can be
considered as an acceptable biomaterial for vital pulp therapy of deep caries in
primary teeth.
AN - rayyan-563560225
AU - Gonna, S.
AU - Ghoname, N.
AU - Kabbash, A.
AU - Yagi, A.
DO - 10.17554/j.issn.2224-3992.2019.08.842
IS - 5
KW - acemannan
formocresol
polysaccharide
Aloe vera
article
child
clinical article
deciduous tooth
dental caries
follow up
gingiva disease
gingiva swelling
human
pain
pulpectomy
pulpotomy
swelling
tooth disease
tooth radiography
LA - English
PY - 2019
SN - ["2224-6509", "2224-3992"]
SP - 2946-2951
ST - Efficacy of aloe vera as a pulpotomy agent in children primary teeth:
Clinical and radiographic studies
T2 - J. Gastroenterol. Hepatol. Res.
TI - Efficacy of aloe vera as a pulpotomy agent in children primary teeth:
Clinical and radiographic studies
VL - 8
ID - 13599
ER -
TY - JOUR
AB - AIM: The present study was conducted to compare effects of acemannan and 3
Mix antibiotic (ciprofloxacin, amoxicillin and metronidazole) as pulpotomy in non-
vital primary molars. And assess the antibacterial effect of acemannan and 3 Mix.
MATERIALS AND METHODS: Aloe vera gel high molecular weight fractions (AHM)
containing native ingredients of polysaccharide (acemannan) and glycoprotein
(verectin) were obtained by using the patented hyper dry system after washing out
coloured materials with running water from Aloe vera gel slurry. Twenty healthy
children aged from four to eight years, they were selected from patients attending
outpatient clinic of Pediatric Dentistry department. Each child had at least
bilateral non vital lower primary molar indicated for non -vital pulpotomy. Non
vital pulpotomy was done in both groups; where group I treated by 3Mix antibiotics,
while AHM, acemannan used in group II. The study cases were recalled after three,
nine and twelve months for clinical and radiographic evaluation. RESULTS: The
overall clinical and radigraphical success rate of acemannan group was 82%, while
3mix antibiotic group was 18%. Fruther more, group 2 AHM showed better improvement
in intraradicular bone density with treatment than group I 3trimix which was
statistically significant p > 0.05. CONCLUSION: The acemannan showed higher
clinical and radiographic success rate compared to 3mix antibiotic as a
pulpulpotomy agent in non-vital primary molars. It can be considered as an
acceptable biomaterial for nonvital pulp therapy of deep caries in primary teeth.
AN - rayyan-563559949
AU - Gonna, S.
AU - Ghouraba, R. F.
AU - Eissa, R.
AU - Kabbash, A.
AU - Yagi, A.
AU - Metwally, N. M.
DO - 10.17554/j.issn.2224-3992.2021.10.1028
IS - 5
KW - acemannan
amoxicillin
ciprofloxacin
gel
glycoprotein
metronidazole
zinc oxide
Aloe vera
article
bacterial growth
bone density
child
clinical article
clinical evaluation
controlled study
deciduous tooth
Escherichia coli
human
molar tooth
molecular weight
periodontal disease
preschool child
pulpotomy
school child
tooth abscess
tooth pain
tooth radiography
LA - English
PY - 2021
SN - ["2224-6509", "2224-3992"]
SP - 3577-3586
ST - Clinical, radiographical and antibacterial evaluation of acemannan sponge and
tri-mix used in treatment of non vital primary molars
T2 - J. Gastroenterol. Hepatol. Res.
TI - Clinical, radiographical and antibacterial evaluation of acemannan sponge and
tri-mix used in treatment of non vital primary molars
VL - 10
ID - 13323
ER -
TY - JOUR
AN - rayyan-563560012
AU - Gonzalez-Alvarez, M.
IS - 3
KW - chitosan
cisplatin
doxorubicin
eye drops
gemcitabine
glutamic acid
glutathione
glycerol
glycerol 2 phosphate
linezolid
magnesium stearate
metronidazole
minocycline
nicardipine
niosome
nuclease
phospholipid
polyglactin
ruthenium complex
ruthenium polypyridyl dipyridophenazine 2 (phenyl) imidazo[4,5 f]
[1,10]phenanthroline
single walled nanotube
tenofovir alafenamide
unclassified drug
xerogel
zidovudine
aerosol
cancer cell line
cancer therapy
drug release
drug solubility
drug stability
drug structure
duodenum
editorial
enzyme activity
Escherichia coli
G1 phase cell cycle checkpoint
IC50
in vitro study
lung cancer
nanoencapsulation
nonhuman
particle size
periodontal disease
pH
publication
spray drying
synthesis
LA - English
PY - 2021
SN - 1999-4923
ST - Controlled delivery formulations
T2 - Pharmaceutics
TI - Controlled delivery formulations
VL - 13
ID - 13386
ER -
TY - JOUR
AB - OBJECTIVE: Mouthwash is effective in maintaining oral hygiene in patients;
however, there is concern that it may adversely affect human oral mucosa. We
evaluated a pH-neutral electrolyzed super-oxidized solution (ESS, tradename
OxOral®) combined with dental scaling in periodontitis patients. This longitudinal
study was conducted with 34 patients divided into three groups. The control group
treated with scaling plus saline, the second with scaling plus ESS mouthwash, and
another with scaling plus ESS mouthwash and gel. The plaque index (PI), gingival
index (GI), and probing depth (PD) were determined before and after periodontal
treatment. RESULTS: The final PI and GI decreased compared with the initial
measurements in the three treatment groups (p < 0.05). Scaling plus ESS mouthwash
and gel significantly reduced the final PI, GI, and DP compared to the control
group (p < 0.05). CONCLUSION: Our study shows the antiseptic properties of ESS with
mouthwash and gel. Further studies are needed to verify the results.
AN - rayyan-563560948
AU - González-Cantú, C. C.
AU - Torres-Muñoz, Á
AU - Urrutia-Baca, V. H.
AU - Sánchez-García, G. A.
AU - De La Garza-Ramos, M. A.
DO - 10.1016/j.heliyon.2022.e12291
IS - 12
J2 - Heliyon
LA - eng
N1 - Autonomous University of Nuevo León, Center for Research and Development in
Health Sciences (CIDICS), General Odontology and Specialties. Dr. Aguirre Pequeño
and Silao St, Mitras Centro, 64460, Monterrey, Nuevo Leon, Mexico.; Autonomous
University of Nuevo León, Center for Research and Development in Health Sciences
(CIDICS), General Odontology and Specialties. Dr. Aguirre Pequeño and Silao St,
Mitras Centro, 64460, Monterrey, Nuevo Leon, Mexico.; Autonomous University of
Nuevo León, School of Biological Sciences. the Immunology and Virology Laboratory.
Pedro de Alba and Manuel L. Barragán St, Ciudad Universitaria, 66450, San Nicolás
de Los Garza, Nuevo Leon, Mexico.; Autonomous University of Nuevo León, Center for
Research and Development in Health Sciences (CIDICS), General Odontology and
Specialties. Dr. Aguirre Pequeño and Silao St, Mitras Centro, 64460, Monterrey,
Nuevo Leon, Mexico.; Autonomous University of Nuevo León, Center for Research and
Development in Health Sciences (CIDICS), General Odontology and Specialties. Dr.
Aguirre Pequeño and Silao St, Mitras Centro, 64460, Monterrey, Nuevo Leon, Mexico.
PY - 2022
SN - 2405-8440 (Print)
SP - e12291
ST - Antibacterial efficacy of a pH-neutral electrolyzed super-oxidized solution
for nonsurgical periodontal treatment
T2 - Heliyon
TI - Antibacterial efficacy of a pH-neutral electrolyzed super-oxidized solution
for nonsurgical periodontal treatment
VL - 8
Y2 - 12
ID - 14322
ER -
TY - JOUR
AB - OBJECTIVE: To determine the efficacy of a gel containing propolis extract,
nanovitamin C and nanovitamin E as adjuvant to mechanical debridement in the
treatment of peri-implant mucositis (PM). BACKGROUND: Propolis has anti-
inflammatory and antibacterial effect that may improve peri-implant health.
METHODS: A randomized, double-blind study was performed on patients with at least
one implant with PM. Participants received a professional prophylaxis and were
instructed to use either test or a control gel as toothpaste three times/day for 1
month. Clinical and microbiological parameters were evaluated. PM resolution was
considered in absence of bleeding on probing (BOP). Data were analysed with Mann-
Whitney U, Wilcoxon signed-rank and chi-square tests. RESULTS: Forty-six patients
participated (23 in each group). After treatment, 26.1% of test patients showed
complete PM resolution versus 0% in control group (p = .02). Significant reductions
were observed in plaque index (p = .03), BOP (p = .04) and probing depths (p
= .027) in test compared with control group. The reduction in Tannerella forsythia
was statistically greater in test than in control group at 1-month follow-up (p
= .02). Porphyromonas gingivalis was statistically reduced in test group from
baseline to 1-month follow-up (p = .05). CONCLUSION: Test gel clinically improved
PM and showed certain antimicrobial effect after 1 month in comparison with control
group. Further long-term clinical trials are required to confirm these results.
AN - rayyan-563559956
AU - González-Serrano, J.
AU - López-Pintor, R. M.
AU - Serrano, J.
AU - Torres, J.
AU - Hernández, G.
AU - Sanz, M.
DO - 10.1111/jre.12886
IS - 5
KW - plant extract
propolis
controlled study
human
mucosa inflammation
periimplantitis
tooth implant
LA - English
PY - 2021
SN - 1600-0765
SP - 897-906
ST - Short-term efficacy of a gel containing propolis extract, nanovitamin C and
nanovitamin E on peri-implant mucositis: A double-blind, randomized, clinical trial
T2 - J Periodontal Res
TI - Short-term efficacy of a gel containing propolis extract, nanovitamin C and
VL - 56
ID - 13330
ER -
TY - JOUR
AB - Objective To determine the efficacy of a gel containing propolis extract,
nanovitamin C and nanovitamin E as adjuvant to mechanical debridement in the
treatment of peri-implant mucositis (PM). Background Propolis has anti-inflammatory
and antibacterial effect that may improve peri-implant health. Methods A
randomized, double-blind study was performed on patients with at least one implant
with PM. Participants received a professional prophylaxis and were instructed to
use either test or a control gel as toothpaste three times/day for 1 month.
Clinical and microbiological parameters were evaluated. PM resolution was
considered in absence of bleeding on probing (BOP). Data were analysed with Mann-
Whitney U, Wilcoxon signed-rank and chi-square tests. Results Forty-six patients
participated (23 in each group). After treatment, 26.1% of test patients showed
complete PM resolution versus 0% in control group (p = .02). Significant reductions
were observed in plaque index (p = .03), BOP (p = .04) and probing depths (p
= .027) in test compared with control group. The reduction in Tannerella forsythia
was statistically greater in test than in control group at 1-month follow-up (p
= .02). Porphyromonas gingivalis was statistically reduced in test group from
baseline to 1-month follow-up (p = .05). Conclusion Test gel clinically improved PM
and showed certain antimicrobial effect after 1 month in comparison with control
group. Further long-term clinical trials are required to confirm these results.
AN - rayyan-563562473
AU - Gonzalez-Serrano, J.
AU - Lopez-Pintor, R. M.
AU - Serrano, J.
AU - Torres, J.
AU - Hernandez, G.
AU - Sanz, M.
DO - 10.1111/jre.12886
IS - 5
PY - 2021
SN - ["0022-3484", "1600-0765"]
SP - 897-906
ST - Short-term efficacy of a gel containing propolis extract, nanovitamin C and
T2 - JOURNAL OF PERIODONTAL RESEARCH
TI - Short-term efficacy of a gel containing propolis extract, nanovitamin C and
VL - 56
Y2 - 10
ID - 15847
ER -
TY - JOUR
AB - OBJECTIVES: To evaluate the efficacy of a gel-containing propolis extract,
nanovitamin C, and nanovitamin E as adjuvants to professional plaque removal on
desquamative gingivitis (DG). MATERIALS AND METHODS: A randomized clinical trial
was conducted on patients suffering DG due to mucocutaneous diseases. Patients
received professional supragingival prophylaxis with oral hygiene instructions and
were randomly assigned to use test or control gels as toothpaste and to apply it on
DG lesions 3 times/day for 4 weeks. DG clinical score (DGCS), clinical periodontal
variables, and visual analog scale (VAS) for pain and oral health impact profile
(OHIP-14) were collected at baseline, 2 and 4 weeks. RESULTS: Twenty-two patients
were randomly assigned to test (n = 11) or control group (n = 11). Eighteen had
diagnosis of oral lichen planus and four of mucous membrane pemphigoid. DGCS
statistically decreased in both groups after treatment with no significant
differences between groups. Clinical periodontal outcomes decreased in both groups,
but no significant differences were observed. Periodontal variables statistically
improved only in test group after treatment. VAS and OHIP-14 scores decreased in
test and control groups without significant differences. However, only one test
group showed a statistically significant decrease in VAS and OHIP-14 scores after
treatment. No adverse effects were reported. CONCLUSIONS: Test gel may alleviate DG
and improve quality of life without side effects. CLINICAL RELEVANCE: A gel-
containing propolis extract, nanovitamin C, and nanovitamin E as adjuvants to
mechanical debridement may improve both clinical and patient related outcomes in DG
patients without side effects. CLINICAL TRIAL REGISTRATION: The study protocol was
registered at clinicaltrials.gov with the following number: NCT05124366 on October
16, 2021.
AN - rayyan-563559753
AU - González-Serrano, J.
AU - Serrano, J.
AU - Sanz, M.
AU - Torres, J.
AU - Hernández, G.
AU - López-Pintor, R. M.
DO - 10.1007/s00784-022-04653-0
IS - 2
KW - NCT05124366
propolis
controlled study
gingivitis
human
lichen planus
mucous membrane pemphigoid
pathology
quality of life
LA - English
PY - 2023
SN - 1436-3771
SP - 879-888
ST - Efficacy and safety of a bioadhesive gel containing propolis extract,
nanovitamin C and nanovitamin E on desquamative gingivitis: a double-blind,
randomized, clinical trial
TI - Efficacy and safety of a bioadhesive gel containing propolis extract,
nanovitamin C and nanovitamin E on desquamative gingivitis: a double-blind,
randomized, clinical trial
VL - 27
ID - 13127
ER -
TY - JOUR
AB - Background: Nanotechnology has been emerging as an interdisciplinary field
that is undergoing rapid development and has brought enormous changes in dentistry.
Solanum Nigrum is a medical plant with high antimicrobial and antiinflammatory
properties. Since periodontal diseases occur as a result of inflammatory processes,
this vitro study has been done to evaluate the anti-inflammatory activity of
solanum nigrum extract and its based selenium nano formulations to incorporate into
periodontics. Materials and Method: The collection and preparation of solanum
nigrum extract was done and stored for further use. Synthesis of selenium
nanoparticles was done with the addition of glacial acetic acid along with selenium
nitrate. Centrifugation was done and characterisation of selenium nanoparticles
using ultraviolet (UV)- vie-spectroscopy spectroscopy. The anti-inflammatory
activity of selenium nanoparticles was measured and compared using the standard
diclofenac sodium assay. Results: The anti-inflammatory activity of solanum nigrum
infused selenium nanoformulation increased with increase in concentrations. At
30uL, 40uL Selenium nanoparticles showed a higher antiinflammatory activity than
standard, Selenium has better anti-inflammatory activities at higher concentrations
when compared to standard diclofenac sodium. Conclusion: Selenium Nanoparticles
have better anti-inflammatory activity when compared to S.nigrum infused Selenium
nanoformulations. Further formulations of solanum nigrum with other nanoparticles
in various forms such as gel and microspheres can be potentially used for
controlled drug delivery in the treatment of periodontitis.
AN - rayyan-563560153
AU - Gopalasamy, K.
AU - Ramamurthy, J.
DO - 10.31838/ijpr/2020.SP1.426
KW - acetic acid
diclofenac
selenium
selenium nanoparticle
Solanum nigrum extract
article
dentistry
glomerulonephritis
hypersensitivity
in vitro study
periodontal disease
serum sickness
Solanum nigrum
LA - English
PY - 2020
SN - 0975-2366
SP - 3151-3158
ST - Evaluation of anti-inflammatory activity of solanum nigrum infused selenium
nanoparticles - An in vitro study
TI - Evaluation of anti-inflammatory activity of solanum nigrum infused selenium
nanoparticles - An in vitro study
VL - 12
ID - 13527
ER -
TY - JOUR
AB - A number of ways have been investigated for administration of antibacterial
agents in dealing withplaque-initiated periodontal disease. These include prolonged
release intrapocket devices which are inserted at diseased sites. Intrapocket drug
delivery system was designed which contain Doxycycline Hyclate; an antibacterial
agent. The formulations were so developed with an aim to reduce the dose of a drug,
to target the drug to the specific site and to maintain dosage at its absorption
site for an extended period of time thereby improves the patient compliance. The
study was aimed towards by formulating the periodontal in situ gels by temperature
induced gelation technique with the utilization of polymer Pluronic F127 which is
synthetically prepared. The Pluronic F127 showed the sol-gel transition phenomenon
in between 27-37 °C. In situ gels were prepared and characterized/evaluated for its
physicochemical properties such as pH, gelation properties, rheology, gel strength,
mucoadhesion, drug content, in-vitro, and ex-vivo drug release rate, texture
analysis and Differential Scanning Colorimetry etc. The formulation found to be
solution at room temperature and forms gel after installation into periodontal
pocket hence leadingto increase in retention time and to slowly release the drug
into pocket. The results of characterization of formulation were found to be
satisfactory and hence significant bioavailability can be increased, so these in
situ gelling systems will be useful in future for improving therapeutic efficacy of
Doxycycline hyclate in treatment of Periodontitis. Owing to these properties it can
be used as an effective delivery system for the intrapocket route.
AN - rayyan-563560254
AU - Gorle, A. P.
AU - Khairnar, D. P.
IS - 4
KW - transmucosal drug delivery system
antiinfective agent
doxycycline hyclate
poloxamer
sodium hydroxide
article
bioavailability
drug release
flow kinetics
gelation
mucoadhesion
periodontitis
physical chemistry
thermography
viscosity
LA - English
PY - 2018
SN - ["1726-6890", "1735-0328"]
SP - 1550-1562
ST - An approach to improve therapeutic efficacy of doxycycline hyclate in
T2 - Iran. J. Pharm. Res.
TI - An approach to improve therapeutic efficacy of doxycycline hyclate in
VL - 17
ID - 13628
ER -
TY - JOUR
AB - Periodontal diseases are one of the most significant challenges in dental
health. It is estimated that only a few percent of the worldwide population have
entirely healthy teeth, and according to WHO, oral diseases may affect up to 3.5
billion people worldwide. One of the most serious oral diseases is periodontitis,
an inflammatory disease affecting periodontal tissues, caused by pathogenic
bacteria and environmental factors such as the ageing population, abuse of tobacco
products, and lack of adequate oral hygiene due low public awareness. Plant
materials are widely and successfully used in the management of many conditions,
including periodontitis. Plant materials for periodontitis exhibit antibacterial,
anti-inflammatory, antioxidant activities and affect the periodontium structure.
Numerous studies demonstrate the advantages of phytotherapy for periodontitis
relief and indicate the usefulness of Baikal skullcap root, Pomegranate fruit peel
and root cortex, Tea leaves, Chamomile flowers, Magnolia bark, Blackberry leaves
and fruits, Cranberry fruits and Lippia sidoides essential oil. This review aims to
analyze the use and applicability of selected plant materials in periodontitis
management since it is of paramount importance to evaluate the evidence of the
traditionally used plant materials in light of continuously growing interest in
phytotherapy and its adjuvant role in the treatment of periodontitis.
AN - rayyan-563562303
AU - Gosciniak, A.
AU - Paczkowska-Walendowska, M.
AU - Skotnicka, A.
AU - Ruchala, M. A.
IS - 12
PY - 2021
SN - 1999-4923
ST - Can Plant Materials Be Valuable in the Treatment of Periodontal Diseases?
Practical Review
T2 - PHARMACEUTICS
TI - Can Plant Materials Be Valuable in the Treatment of Periodontal Diseases?
Practical Review
VL - 13
Y2 - 12
ID - 15677
ER -
TY - JOUR
AB - Periodontal diseases are one of the most significant challenges in dental
health. It is estimated that only a few percent of the worldwide population have
entirely healthy teeth, and according to WHO, oral diseases may affect up to 3.5
billion people worldwide. One of the most serious oral diseases is periodontitis,
an inflammatory disease affecting periodontal tissues, caused by pathogenic
bacteria and environmental factors such as the ageing population, abuse of tobacco
products, and lack of adequate oral hygiene due low public awareness. Plant
materials are widely and successfully used in the management of many conditions,
including periodontitis. Plant materials for periodontitis exhibit antibacterial,
anti-inflammatory, antioxidant activities and affect the periodontium structure.
Numerous studies demonstrate the advantages of phytotherapy for periodontitis
relief and indicate the usefulness of Baikal skullcap root, Pomegranate fruit peel
and root cortex, Tea leaves, Chamomile flowers, Magnolia bark, Blackberry leaves
and fruits, Cranberry fruits and Lippia sidoides essential oil. This review aims to
analyze the use and applicability of selected plant materials in periodontitis
management since it is of paramount importance to evaluate the evidence of the
traditionally used plant materials in light of continuously growing interest in
phytotherapy and its adjuvant role in the treatment of periodontitis.
AN - rayyan-563559934
AU - Gościniak, A.
AU - Paczkowska-Walendowska, M.
AU - Skotnicka, A.
AU - Ruchała, M. A.
IS - 12
KW - Acorus calamus extract
Alecrim pimento extract
Aloe vera extract
baicalin
Camelia sinensis extract
ciprofloxacin
dentosept
dentosept a
ellagic acid
flavonoid
herbaceous agent
herbadent
interleukin 1beta
interleukin 6
kamillosan konzentrat
kamillosan mundund rachenspray
kamistad gel
kamistad senzitiv
Magnolia officinalis extract
Matricaria flower extract
mucosit
ofloxacin
peppermint
plant extract
pomegranate extract
Salvia officinalis extract
Salvia sclarea extract
septosan fix
tannin
unclassified drug
Vaccinum macrocarpon extract
bacterial load
cell activation
clinical feature
disease course
drug formulation
human
medicinal plant
mouth hygiene
nonhuman
oxidative stress
pathogenesis
periodontal disease
periodontitis
phytotherapy
review
signal transduction
tissue injury
treatment duration
LA - English
PY - 2021
SN - 1999-4923
ST - Can plant materials be valuable in the treatment of periodontal diseases?
Practical review
T2 - Pharmaceutics
TI - Can plant materials be valuable in the treatment of periodontal diseases?
Practical review
VL - 13
ID - 13308
ER -
TY - JOUR
AB - Aim: The aim of the present study was to evaluate the clinical and
microbiological effects of subgingival administration of 1% chlorhexidine gel
(Chlorhexamed® 1% gel) in patients with chronic periodontitis. Settings and Design:
The study was done in a parallel-arm design with a total of 30 patients with 60
sites suffering from chronic periodontitis. The patients were divided into control
and experimental groups. Materials and Methods: The clinical parameters recorded
were plaque index, gingival index, modified sulcular bleeding index, probing pocket
depth and relative attachment level at baseline, 1 month and 3 month.
Microbiological colony-forming units were assessed for Porphyromonas gingivalis,
Fusobacterium nucleatum and Tannerella forsythia at baseline, 1 week, 1 month and 3
months. The control group received scaling and root planing (SRP) after baseline
evaluation; however, the experimental group received the application of
Chlorhexamed® gel within 48 hours after SRP. Then, the values obtained were
subjected to statistical analysis. Results: Both groups showed significant
improvement from the baseline to 3 months in all clinical and microbiological
parameters. The experimental group showed better improvement in all parameters.
Conclusion: The use of Chlorhexamed® gel has proven to be an efficacious adjunct
with SRP in the treatment of chronic periodontitis.
AN - rayyan-563559876
AU - Goswami, V.
AU - Yeltiwar, R. K.
AU - Kujur, S.
AU - Agrawal, P.
AU - Bodhi, S.
AU - Bhatnagar, S.
DO - 10.4103/ijdr.ijdr_936_21
IS - 2
KW - chlorhexidine
dental scaling
human
microbiology
root planing
LA - English
PY - 2022
SN - 1998-3603
SP - 174-179
ST - Evaluation of efficacy of subgingival administration of 1% chlorhexidine gel
as an adjunct to scaling and root planing in the treatment of chronic periodontitis
- A clinical and microbiological study
TI - Evaluation of efficacy of subgingival administration of 1% chlorhexidine gel
as an adjunct to scaling and root planing in the treatment of chronic periodontitis
- A clinical and microbiological study
VL - 33
ID - 13250
ER -
TY - JOUR
AN - rayyan-563561594
AU - Goudanavar, P.
AU - Ali, M.
AU - Wani, S. U. D.
AU - Sreeharsha, N.
DO - 10.22159/ijap.2021v13i3.40604
IS - 3
PY - 2021
SP - 79-86
ST - Formulation and evaluation of in-situ gel containing linezolid in the
T2 - International Journal of Applied Pharmaceutics
TI - Formulation and evaluation of in-situ gel containing linezolid in the
85106949129&doi=10.22159%2fijap.2021v13i3.40604&partnerID=40&md5=d5e79266b58bd5ad84
9641ce163b4833
VL - 13
ID - 14968
ER -
TY - JOUR
AB - Glycyrrhizin, the main saponin of licorice, a surfactant producing aqueous
gel, was tested for its effect on gingival health, as a supplemental agent in a
toothpaste. 40 male and female volunteers brushed their teeth twice daily, with a
toothpaste containing 0.25% and 0.50% glycyrrhizin, or a control toothpaste,
respectively. All 3 toothpastes contained sodium lauryl sulfate as detergent. The
subjects of the 3 groups were examined at days 0, 7, 14, 28, 35 and 42 for plaque,
gingival and bleeding indices. The examiner was unaware of subject assignment. None
of the brushing regimens with the experimental toothpastes induced significant
changes in the examined indices, that were distinct from those observed with the
control toothpaste. The decrease (insignificant) in the indices of the study period
from 0 to 14 days may be considered as an increased oral hygiene awareness by the
subjects examined. Possible explanations for the lack of efficiency in improvement
of plaque, gingival and bleeding indices, may have been an insufficient
glycyrrhizin concentration and/or chemical incompatibility in a toothpaste
containing a mixture of an anionic detergent and an organic antibacterial surface
agent.
AN - rayyan-563561432
AU - Goultschin, J.
AU - Palmon, S.
AU - Shapira, L.
AU - Brayer, L.
AU - Gedalia, I.
DO - 10.1111/j.1600-051x.1991.tb01136.x
IS - 3
J2 - J Clin Periodontol
KW - Adult
Anti-Infective Agents/administration & dosage/*therapeutic use
Dental Plaque/*prevention & control
Dental Plaque Index
Double-Blind Method
Gingival Hemorrhage
Gingivitis/*prevention & control
Glycyrrhetinic Acid/administration & dosage/*analogs & derivatives/therapeutic use
Glycyrrhizic Acid
Humans
Middle Aged
Periodontal Index
Pilot Projects
Time Factors
Toothpastes
LA - eng
N1 - Department of Periodontology, Faculty of Dental Medicine, Jerusalem, Israel.
PY - 1991
SN - 0303-6979 (Print)
SP - 210-2
ST - Effect of glycyrrhizin-containing toothpaste on dental plaque reduction and
gingival health in humans. A pilot study
T2 - Journal of clinical periodontology
TI - Effect of glycyrrhizin-containing toothpaste on dental plaque reduction and
gingival health in humans. A pilot study
VL - 18
Y2 - 3
ID - 14806
ER -
TY - JOUR
AN - rayyan-563562137
AU - Goultschin, J.
AU - Palmon, S.
AU - Shapira, L.
AU - Brayer, L.
AU - Gedalia, I.
DO - 10.1111/j.1600-051X.1991.tb01136.x
IS - 3
PY - 1991
SP - 210-212
ST - Effect of glycyrrhizin‐containing toothpaste on dental plaque reduction and
gingival health in humans: A pilot study
TI - Effect of glycyrrhizin‐containing toothpaste on dental plaque reduction and
gingival health in humans: A pilot study
0026035669&doi=10.1111%2fj.1600-
051X.1991.tb01136.x&partnerID=40&md5=e980d9b73c065745963cf3b39c982eee
VL - 18
ID - 15511
ER -
TY - JOUR
AB - In the present work mucoadhesive gels of Tinidazole that adhere with gums for
an extended time period were prepared and evaluated. Tinidazole (TZ) is an
antibacterial drug used for treatment of Periodontitis. Different gel formulations
were prepared using the bio adhesive polymers like carbopol 974, sodium alginate
and sodium carboxy methyl cellulose. The other additives used are triethanolamine
as an emulsifier and surfactant, glycerol as a means of improving smoothness,
providing lubrication and as humectants, mannitol as the isotonic agent and
methylparaben as a preservative. The physicochemical compatibility of the drug and
the polymer was assessed by FTIR spectroscopy. The prepared gels were evaluated for
various parameters like viscosity, pH, drug content, swelling index, spread ability
and Ex-Vivo drug permeation. Release of Tinidazole from the gels formulated by
employing carbopol 974 extended the drug release up to 6hrs. So the formulations
F7, F8, and F9 were found to be optimized formulae.
AN - rayyan-563560316
AU - Gousia Begum, S.
AU - Sekar, M.
DO - 10.22376/ijpbs.2017.8.2.p48-55
IS - 2
KW - alginic acid
carbomer
glycerol
mannitol
methyl paraben
tinidazole
triethanolamine
article
biocompatibility
drug formulation
drug penetration
drug release
ex vivo study
gel
mucoadhesive buccal gel
pH
physical chemistry
viscosity
LA - English
PY - 2017
SN - 0975-6299
SP - P48-P55
ST - Formulation and evaluation of Tinidazole mucoadhesive Buccal gels
T2 - Int. J. Pharma Bio Sci.
TI - Formulation and evaluation of Tinidazole mucoadhesive Buccal gels
VL - 8
ID - 13690
ER -
TY - JOUR
AB - Periodontal disease is a localized inflammatory disorder, with tissue
destruction resulting from the host response to bacterial antigens and irritants.
Several other risk factors, such as smoking, hormonal changes, diabetes, drugs,
disease, and genetic factors, play an important role in the progression of
periodontal disease. This disease results in the formation of periodontal pockets
or deepened crevices between the gingival and tooth root that produce occasional
pain and discomfort, impaired mastication, and irreversible tooth loss. The primary
rationale for controlled, sustained, and targeted drug delivery is necessary to
achieve better therapeutic outcomes or patient compliance against periodontal
disease and its various stages. Both systemic (liposomes, microspheres,
nanoparticles, hydrogels) and local (fibers, patches, films, gels)
antibiotic/antimicrobial approaches have their important place in periodontal
therapy. The overall goal of this article is to provide the clinician with
information related to the pathogenesis, risk, polymer used for drug delivery, and
current nanotechnological systems for an effective treatment of periodontal
disease. © 2014 Begell House, Inc.
AN - rayyan-563560435
AU - Goyal, G.
AU - Garg, T.
AU - Rath, G.
AU - Goyal, A. K.
DO - 10.1615/CritRevTherDrugCarrierSyst.2014008117
IS - 2
alginic acid
antibiotic agent
cefalexin
chitosan
chlorhexidine
collagen
diclofenac
doxycycline
efenamic acid
ethyl cellulose
indometacin
ipriflavone
ketoprofen
liposome
macrogol
magnesium hydroxide
metronidazole
microsphere
minocycline
nanoparticle
niridazole
polyacrylic acid
polymer
tetracycline
tinidazole
triclosan
unindexed drug
article
gingivitis
human
hydrogel
inflammation
nanotechnology
periodontal disease
periodontal pocket
periodontitis
prevalence
risk factor
smoking
T lymphocyte activation
tooth implant
tooth plaque
LA - English
PY - 2014
SN - ["2162-660X", "0743-4863"]
SP - 89-119
ST - Current nanotechnological strategies for an effective delivery of drugs in
treatment of periodontal disease
TI - Current nanotechnological strategies for an effective delivery of drugs in
VL - 31
ID - 13809
ER -
TY - JOUR
AB - Topical locally delivered minocycline is an adjunctive to non-surgical
periodontal treatment, but there are few reported trials. Previous trials have
reported differences between changes in probing depth in treatment and control
groups, but no differences in probing attachment level. In the present study, 30
subjects were paired according to gender, age, ethnic group, smoking habits, and
probing depths. Both groups received intensive oral hygiene education and root
planing with local anaesthesia. Active or placebo gel was placed subgingivally at
planed sites in each subject according to a double-blind protocol, immediately
after instrumentation, and 2 and 4 weeks later. A periodontal examination was made
with a constant force probe before instrumentation, and 6 and 12 weeks later, 2
subjects failed to complete the study, and their pairs were therefore not included
in the analysis. Results were tested with analysis of covariance. Differences
between groups in mean probing depth did not reach statistical significance at any
visit (baseline: test (T) = 5.93 mm, control (C) = 5.74 mm; 6 weeks: T = 3.53 mm, C
= 3.63 mm; 12 weeks: T = 3.29 mm, C = 3.44 mm), but mean probing attachment levels
were different (p < 0.05) at both reassessments (baseline: T = 6.86 mm, C = 6.83
mm; 6 weeks: T = 4.93 mm, C = 5.30 mm; 12 weeks T = 4.91 mm, C = 5.27 mm). There
was also a difference in the number of sites with bleeding on deep probing at 12
weeks (p < 0.05). This trial showed that adjunctive minocycline gel provided a more
advantageous outcome for nonsurgical periodontal treatment in terms of probing
attachment level and bleeding on deep probing. This trial was a good example of
experimental, as opposed to community, design, and used limited resources to show a
clear result.
AN - rayyan-563561047
AU - Graça, M. A.
AU - Watts, T. L.
AU - Wilson, R. F.
AU - Palmer, R. M.
IS - 4
minocycline
adult
article
clinical trial
female
gel
human
male
methodology
middle aged
nonparametric test
periodontal disease
periodontics
periodontitis
treatment outcome
LA - English
PY - 1997
SN - 0303-6979
SP - 249-253
ST - A randomized controlled trial of a 2% minocycline gel as an adjunct to non-
surgical periodontal treatment, using a design with multiple matching criteria
TI - A randomized controlled trial of a 2% minocycline gel as an adjunct to non-
surgical periodontal treatment, using a design with multiple matching criteria
VL - 24
ID - 14421
ER -
TY - JOUR
AB - Background: Enamel matrix derivative (EMD), the active component of
Emdogain®, is a viable option in the treatment of periodontal disease owing to its
ability to regenerate lost tissue. It is believed to mimic odontogenesis, though
the details of its functioning remain the focus of current research. Objective: The
aim of this article is to review all relevant literature reporting on the
composition/characterization of EMD as well as the effects of EMD, and its
components amelogenin and ameloblastin, on the behavior of various cell types in
vitro. In this way, insight into the underlying mechanism of regeneration will be
garnered and utilized to propose a model for the molecular arrangement and
functioning of EMD. Methods: A review of in vitro studies of EMD, or components of
EMD, was performed using key words "enamel matrix proteins" OR "EMD" OR "Emdogain"
OR "amelogenin" OR "ameloblastin" OR "sheath proteins" AND "cells." Results of this
analysis, together with current knowledge on the molecular composition of EMD and
the structure and regulation of its components, are then used to present a model of
EMD functioning. Results: Characterization of the molecular composition of EMD
confirmed that amelogenin proteins, including their enzymatically cleaved and
alternatively spliced fragments, dominate the protein complex (>90%). A small
presence of ameloblastin has also been reported. Analysis of the effects of EMD
indicated that gene expression, protein production, proliferation, and
differentiation of various cell types are affected and often enhanced by EMD,
particularly for periodontal ligament and osteoblastic cell types. EMD also
stimulated angiogenesis. In contrast, EMD had a cytostatic effect on epithelial
cells. Full-length amelogenin elicited similar effects to EMD, though to a lesser
extent. Both the leucine-rich amelogenin peptide and the ameloblastin peptides
demonstrated osteogenic effects. A model for molecular structure and functioning of
EMD involving nanosphere formation, aggregation, and dissolution is presented.
Conclusions: EMD elicits a regenerative response in periodontal tissues that is
only partly replicated by amelogenin or ameloblastin components. A synergistic
effect among the various proteins and with the cells, as well as a temporal effect,
may prove important aspects of the EMD response in vivo. © 2012 Mary Ann Liebert,
Inc.
AN - rayyan-563560543
AU - Grandin, H. M.
AU - Gemperli, A. C.
AU - Dard, M.
DO - 10.1089/ten.teb.2011.0365
IS - 3
KW - ameloblastin
amelogenin
collagen type 1
enamel matrix derivative
enamel protein
interleukin 6
kallikrein
kallikrein 4
lysosome associated membrane protein 1
matrix metalloproteinase 20
messenger RNA
platelet derived growth factor AB
Smad1 protein
unclassified drug
vasculotropin A
vasculotropin B
vasculotropin C
ameloblast
angiogenesis
biochemical composition
cell adhesion
cell migration
cell proliferation
cell viability
chemical structure
down regulation
electrophoresis
epithelium cell
gene expression
gingiva
human
in vitro study
molecular mechanics
nonhuman
odontoblast
ossification
osteoblast
periodontics
priority journal
protein binding
protein expression
protein function
reversed phase liquid chromatography
review
tooth development
upregulation
zymography
LA - English
PY - 2012
SN - ["1937-3368", "1937-3376"]
SP - 181-202
ST - Enamel matrix derivative: A review of cellular effects in vitro and a model
of molecular arrangement and functioning
T2 - Tissue Eng. Part B. Rev.
TI - Enamel matrix derivative: A review of cellular effects in vitro and a model
of molecular arrangement and functioning
VL - 18
ID - 13917
ER -
TY - JOUR
AB - The self-produced matrix of biofilms, consisting of extracellular polymeric
substances, plays an important role in biofilm adhesion to surfaces and the
structural integrity of biofilms. In dentistry, biofilms cause multiple diseases
such as caries, periodontitis, and pulpitis. Disruption of these biofilms adhering
to dental hard tissues may pose a major challenge since biofilms show higher
tolerance to antimicrobials and antibiotics than planktonic cells. In this study,
the effect of low concentrations of chlorhexidine (CHX) on enzyme-treated
multispecies oral biofilm was investigated in an in vitro model. Six-species
biofilms were enzymatically treated by anaerobic growth in a medium containing
DNase I and proteinase K. Biofilms were exposed to a low concentration of CHX at
defined time points. After 64h, biofilms were either harvested and quantified by
cultural analyses or stained for confocal laser scanning microscopy (CLSM) analyses
using either Live/Dead kit or different fluorescent dyes. A mixture of YoPro1 and
SYTOX™ Green, Fluorescent Brightener 28 (Calcofluor), and SYPRO™ Ruby Protein Gel
Stain was used to stain total DNA, exopolysaccharides, and extracellular proteins,
respectively. Extracellular DNA (eDNA) was visualized via an indirect
immunofluorescence assay (Mouse anti-DNA IgG, Goat anti-Mouse IgG, Streptavidin-
Cy3). Overall, the total colony-forming units significantly decreased after
combined treatment with a low concentration of CHX and enzymes compared to the
group treated with CHX alone (p<0.001). These findings also apply to five species
individually (Streptococcus mutans, Streptococcus oralis, Actinomyces oris,
Veillonella dispar, and Candida albicans) occurring in the biofilms, with
Fusobacterium nucleatum being the only exception. Furthermore, CLSM images showed
less dense biofilms and a reduction in cell numbers after combined treatment
compared to the group without enzymes. The combination of enzymes capable of
disturbing the matrix integrity with antimicrobial agents thus appears to be a
promising approach for biofilm disruption and killing.
AN - rayyan-563559961
AU - Gränicher, K. A.
AU - Karygianni, L.
AU - Attin, T.
AU - Thurnheer, T.
DO - 10.3389/fmicb.2021.741863
KW - confocal laser scanning microscope
chlorhexidine
deoxyribonuclease I
fluorescent dye
proteinase K
streptavidin
Actinomyces
article
bacterial growth
bacterium culture
biofilm
blood sampling
Candida albicans
cell count
colony forming unit
controlled study
gingiva
in vitro study
low drug dose
nonhuman
Veillonella
LA - English
PY - 2021
SN - 1664-302X
ST - Low Concentrations of Chlorhexidine Inhibit the Formation and Structural
Integrity of Enzyme-Treated Multispecies Oral Biofilms
TI - Low Concentrations of Chlorhexidine Inhibit the Formation and Structural
VL - 12
ID - 13335
ER -
TY - JOUR
AB - The self-produced matrix of biofilms, consisting of extracellular polymeric
substances, plays an important role in biofilm adhesion to surfaces and the
structural integrity of biofilms. In dentistry, biofilms cause multiple diseases
such as caries, periodontitis, and pulpitis. Disruption of these biofilms adhering
to dental hard tissues may pose a major challenge since biofilms show higher
tolerance to antimicrobials and antibiotics than planktonic cells. In this study,
the effect of low concentrations of chlorhexidine (CHX) on enzyme-treated
multispecies oral biofilm was investigated in an in vitro model. Six-species
biofilms were enzymatically treated by anaerobic growth in a medium containing
DNase I and proteinase K. Biofilms were exposed to a low concentration of CHX at
defined time points. After 64h, biofilms were either harvested and quantified by
cultural analyses or stained for confocal laser scanning microscopy (CLSM) analyses
using either Live/Dead kit or different fluorescent dyes. A mixture of YoPro1 and
SYTOX (TM) Green, Fluorescent Brightener 28 (Calcofluor), and SYPRO (TM) Ruby
Protein Gel Stain was used to stain total DNA, exopolysaccharides, and
extracellular proteins, respectively. Extracellular DNA (eDNA) was visualized via
an indirect immunofluorescence assay (Mouse anti-DNA IgG, Goat anti-Mouse IgG,
Streptavidin-Cy3). Overall, the total colony-forming units significantly decreased
after combined treatment with a low concentration of CHX and enzymes compared to
the group treated with CHX alone (p<0.001). These findings also apply to five
species individually (Streptococcus mutans, Streptococcus oralis, Actinomyces oris,
Veillonella dispar, and Candida albicans) occurring in the biofilms, with
Fusobacterium nucleatum being the only exception. Furthermore, CLSM images showed
less dense biofilms and a reduction in cell numbers after combined treatment
compared to the group without enzymes. The combination of enzymes capable of
disturbing the matrix integrity with antimicrobial agents thus appears to be a
promising approach for biofilm disruption and killing.
AN - rayyan-563562609
AU - Granicher, K. A.
AU - Karygianni, L.
AU - Attin, T.
AU - Thurnheer, T.
DO - 10.3389/fmicb.2021.741863
PY - 2021
SN - 1664-302X
ST - Low Concentrations of Chlorhexidine Inhibit the Formation and Structural
TI - Low Concentrations of Chlorhexidine Inhibit the Formation and Structural
VL - 12
Y2 - 9 y3 - 28
ID - 15983
ER -
TY - JOUR
AB - The rapid growth in our understanding of the pathogenesis of periodontal
disease has led to a change in therapeutic emphasis, supplementing traditional,
non-specific, mechanical plaque control with a more focused targeting of pathogenic
organisms. New topical preparations provide high antimicrobial doses at diseased
sites without the systemic antibiotic loading which is now, in itself, a cause of
concern due to the increasing tendency of micro-organisms to become resistant to
antimicrobial agents. This article reviews the current methods of delivering
antimicrobial agents to the gingival crevice and evaluates their roles in practical
periodontal therapy.
AN - rayyan-563561043
AU - Greene, P. R.
IS - 5
chlorhexidine
metronidazole
gel
human
periodontal disease
periodontitis
review
LA - English
PY - 1997
SN - 0305-5000
SP - 204-207
ST - Locally delivered antimicrobials in periodontal therapy
T2 - Dent Update
TI - Locally delivered antimicrobials in periodontal therapy
VL - 24
ID - 14417
ER -
TY - JOUR
AB - Background: This commentary compares the abilities of full-mouth disinfection
(FDIS), full-mouth root planing (FRP), and partial-mouth disinfection (PDIS) to
improve periodontal health. FDIS consists of 4 quadrants of root planing completed
within 24 hours with adjunctive chlorhexidine therapies (e.g., rinsing, subgingival
irrigation, tongue brushing). FRP denotes 4 quadrants of root planing performed
within 24 hours, and PDIS refers to root planing individual quadrants of the
dentition, spaced 2 weeks apart. A basic premise of administering full-mouth
therapy (FDIS or FRP) is to eliminate or reduce bacterial reservoirs within the
oral cavity that could inhibit optimal healing of treated sites or cause
periodontal disease initiation or progression. Methods: Controlled clinical trials
that compared the abilities of PDIS and full-mouth root planing with and without
adjunctive chlorhexidine chemotherapy to alter periodontal status were reviewed.
Results: Several studies conducted at one treatment center indicated that FDIS and
FRP attained greater therapeutic improvements than PDIS with respect to decreasing
probing depths (PD), gaining clinical attachment (CAL), diminishing bleeding upon
probing, and reducing the subgingiual microflora. However, the magnitude of PD
reductions and gains of clinical attachment must be carefully interpreted, because
initial PD measurements were usually determined after scaling and root planing,
which may have caused the results to be overstated. Furthermore, in studies that
addressed the utility of FDIS, it was not possible to determine if benefits induced
beyond PDIS were due to FRP or administration of multifaceted intraoral
chlorhexidine treatments or a combination of both therapies. One investigation that
had protocol limitations indicated that similar results were attained by FRP with
and without adjunctive chemotherapy. In contrast, recent studies from 2 other
treatment centers indicated that there were no significant differences when the
efficacy of quadrant-by-quadrant root planing was compared to FRP or FDIS with
regard to PD reduction, gains of clinical attachment, and impact on the magnitude
and quality of the immune response. Possible Clinical Implications: Conceptually,
full-mouth therapy (FRP or FDIS) could reduce the number of patient-visits and
facilitate more efficient use of treatment time. In addition, there appears to be
no major adverse reactions to full-mouth root planing with or without adjunctive
chemotherapy. However, small study populations and non-corroborating data from
different treatment centers indicate that additional randomized clinical trials are
needed to determine if fullmouth therapy provides clinically relevant improvements
beyond PDIS.
AN - rayyan-563562573
AU - Greenstein, G.
DO - 10.1902/jop.2002.73.7.797
IS - 7
PY - 2002
SN - ["0022-3492", "1943-3670"]
SP - 797-812
ST - Full-mouth therapy versus individual quadrant root planing: A critical
commentary
TI - Full-mouth therapy versus individual quadrant root planing: A critical
commentary
VL - 73
Y2 - 7
ID - 15947
ER -
TY - JOUR
AB - THIS REVIEW ARTICLE EVALUATES the role of local drug delivery systems in the
management of periodontal diseases. The efficacy of several local delivery devices
(i.e., tetracycline fibers, metronidazole and minocycline gels, chlorhexidine
chips, and doxycycline polymer) which are either commercially available in the
United States or abroad, or are currently under consideration for Food and Drug
Administration (FDA) approval are discussed. The drug delivery systems are assessed
with regard to their functional characteristics, effectiveness as a monotherapy, as
compared to scaling and root planing, and ability to enhance conventional therapy.
Furthermore, controversies associated with local delivery are addressed (e.g.,
induction of bacterial resistant strains, the efficacy of systemic versus local
drug delivery, and whether local drug delivery should function as an alternative or
as an adjunct to conventional treatment).
AN - rayyan-563561029
AU - Greenstein, G.
AU - Polson, A.
DO - 10.1902/jop.1998.69.5.507
IS - 5
KW - chlorhexidine
doxycycline
metronidazole
minocycline
tetracycline
biodegradation
drug approval
drug efficacy
Food and Drug Administration
gel
periodontal disease
review
LA - English
PY - 1998
SN - 0022-3492
SP - 507-520
ST - The role of local drug delivery in the management of periodontal diseases: A
comprehensive review
TI - The role of local drug delivery in the management of periodontal diseases: A
comprehensive review
VL - 69
ID - 14403
ER -
TY - JOUR
AB - Background: Tetracyclines, particularly doxycycline (Doxy), and their non-
antimicrobial chemically-modified derivatives (CMTs) inhibit the activities of
human matrix metalloproteinases (MMPs), and reduce the severity and progression of
periodontal disease in animal models and humans. In this study, the effects of Doxy
and CMT-1, -3, and -5 on proteolytic, serpinolytic, and progelatinase-B activation
activities of potent periodontopathogens were studied. Methods: The effect of Doxy
and CMTs (0.5 to 50 μM) on proteolytic activities were investigated by incubating
bacteria with chromogenic substrates or human serum albumin. A collagenolytic
fraction of Porphyromonas gingivalis was used to evaluate the effect of these
substances on collagenolytic (type I collagen) and serpinolytic (α1-proteinase
inhibitor) activities. Lastly, the effect of Doxy on progelatinase-B (pro-MMP-9)
activation by purified proteinases from P. gingivalis and Treponema denticola was
investigated by SDS-PAGE/Western immunoblotting. Results: Doxy and CMTs, except
CMT-5 which lacks the structural elements required for cation chelation, inhibited
Arg- and Lys-gingipain activities as well as collagenolytic activity of P.
gingivalis. Doxy and CMTs did not markedly affect the chymotrypsin-like activity of
T. denticola but inhibited its trypsin-like activity. In addition, degradation of
human serum albumin by cells of P. gingivalis and T. denticola was strongly
inhibited by Doxy and CMT-1. Doxy and CMT-1 also inhibited the inactivation of α1-
proteinase inhibitor (serpinolytic activity) by a collagenolytic fraction of P.
gingivalis. Lastly, Doxy prevented the latent to active conversion of human
neutrophil progelatinase-B (pro-MMP-9) by Arg-gingipains A/B of P. gingivalis but
not by the chymotrypsin-like proteinase of T. denticola. Conclusions: Data from
this study suggest that Doxy and CMTs have the potential to inhibit the
periodontopathogenic bacterial proteinases, which contribute to tissue destruction
cascades during periodontitis directly and indirectly by triggering the host
response.
AN - rayyan-563560910
AU - Grenier, D.
AU - Plamondon, P.
AU - Sorsa, T.
AU - Lee, H. M.
AU - McNamara, T.
AU - Golub, L. M.
AU - Teronen, O.
AU - Mayrand, D.
DO - 10.1902/jop.2002.73.1.79
IS - 1
KW - alpha 1 antitrypsin
arginine
cation
chromogenic substrate
chymotrypsin
collagen type 1
doxycycline
gelatinase B
gingipain R
human serum albumin
lysine
proteinase
trypsin
animal cell
article
chelation
controlled study
disease course
disease model
disease severity
dose response
drug effect
enzyme activation
enzyme activity
enzyme inactivation
enzyme inhibition
enzyme purification
human
human cell
human tissue
immune response
incubation time
inhibition kinetics
neutrophil
nonhuman
pathogenicity
periodontal disease
periodontitis
protein degradation
tissue injury
Treponema denticola
Western blotting
LA - English
PY - 2002
SN - 0022-3492
SP - 79-85
ST - Inhibition of proteolytic, serpinolytic, and progelatinase-B activation
activities of periodontopathogens by doxycycline and the non-antimicrobial
chemically modified tetracycline derivatives
TI - Inhibition of proteolytic, serpinolytic, and progelatinase-B activation
activities of periodontopathogens by doxycycline and the non-antimicrobial
chemically modified tetracycline derivatives
VL - 73
ID - 14284
ER -
TY - JOUR
AB - BACKGROUND, AIMS: Conventional treatment of chronic periodontitis involves
mechanical debridement of periodontal pockets. Recently, subgingival antimicrobials
have been used adjunctively following such debridement. This 2-centre study
compared the clinical effects of subgingival scaling (SRP) with SRP plus
subgingival application of 25% metronidazole gel, Elyzol (SRP+gel), in patients
with chronic adult periodontitis. METHOD: Voluntary informed written consent was
obtained from 45 subjects at the Eastman (mean age 46, range 34-63) and 43 subjects
at RAF Halton (mean age 47, range 34-71) who participated in this blind, randomised
split-mouth design study. All had at least 2 sites in each quadrant with probing
pocket depth (PPD) > or = 5 mm. PPD, bleeding on probing (BOP), and clinical
probing attachment levels (CAL) measured using a stent, were recorded at baseline
and at 1, 3, 6 and 9 months post-therapy. After subgingival scaling of all
quadrants, 2 quadrants were randomly selected to be treated with metronidazole gel.
RESULTS: A paired t-test on baseline values showed no bias between groups. Both
treatments effectively reduced the signs of periodontitis. At each follow-up visit,
reduction in PPD, CAL and BOP after the combined treatment was greater than for SRP
alone. Paired t-tests showed that the improvement in the SRP+gel group was
statistically significantly better (p<0.001) than for SRP alone (mean 0.5 +/- 0.6
mm. 95% CI 0.4-0.6 mm.) Similarly, the % of sites which improved to a final pocket
depth of < or = 3 mm and the % of sites which improved over the 9 months of the
study by as much as > or = 2 mm were greater for SRP+gel than for SRP alone.
CONCLUSIONS: At the end of the study, the mean reductions for PPD were 1.0 mm (SRP)
compared to 1.5 mm (SRP+gel), and for CAL they were 0.4 mm (SRP) compared to 0.8 mm
(SRP+gel), with mean difference for CAL between treatments of 0.4 +/- 0.6 mm (95%
confidence intervals of 0.3-0.6 mm). The combination therapy of SRP+gel was
superior to the conventional treatment of SRP alone, and these differences were
maintained for 9 months.
AN - rayyan-563560931
AU - Griffiths, G. S.
AU - Smart, G. J.
AU - Bulman, J. S.
AU - Weiss, G.
AU - Shrowder, J.
AU - Newman, H. N.
IS - 12
KW - acylglycerol
drug derivative
Elyzol Dentalgel
metronidazole
sesame seed oil
adult
article
chronic disease
clinical trial
comparative study
controlled study
female
human
male
middle aged
multicenter study
nonparametric test
periodontics
periodontitis
treatment outcome
LA - English
PY - 2000
SN - 0303-6979
SP - 910-917
ST - Comparison of clinical outcomes following treatment of chronic adult
periodontitis with subgingival scaling or subgingival scaling plus metronidazole
gel
TI - Comparison of clinical outcomes following treatment of chronic adult
periodontitis with subgingival scaling or subgingival scaling plus metronidazole
gel
VL - 27
ID - 14305
ER -
TY - JOUR
AN - rayyan-563561463
AU - Grilc, N. K.
AU - Zidar, A.
AU - Kocbek, P.
AU - Rijavec, T.
AU - Colja, T.
AU - Lapanje, A.
AU - Jeras, M.
AU - Gobec, M.
AU - Mlinarič-Raščan, I.
AU - Gašperlin, M.
AU - Kristl, J.
DO - 10.1016/j.jconrel.2023.01.082
PY - 2023
SP - 371-384
ST - Nanofibers with genotyped Bacillus strains exhibiting antibacterial and
immunomodulatory activity
T2 - Journal of Controlled Release
TI - Nanofibers with genotyped Bacillus strains exhibiting antibacterial and
85147732673&doi=10.1016%2fj.jconrel.2023.01.082&partnerID=40&md5=1e7ca320b1b0bf8d61
e9841177950cd7
VL - 355
ID - 14837
ER -
TY - JOUR
AB - Biofilm-associated diseases such as periodontitis are widespread and
challenging to treat which calls for new strategies for their effective management.
Probiotics represent a promising approach for targeted treatment of dysbiosis in
biofilm and modulation of host immune response. In this interdisciplinary study,
nanofibers with two autochthonous Bacillus strains 27.3.Z and 25.2.M were
developed. The strains were isolated from the oral microbiota of healthy
individuals, and their genomes were sequenced and screened for genes associated
with antimicrobial and immunomodulatory activities, virulence factors, and
transferability of resistance to antibiotics. Spores of two Bacillus strains were
incorporated individually or in combination into hydrophilic poly(ethylene oxide)
(PEO) and composite PEO/alginate nanofibers. The nanofiber mats were characterised
by a high loading of viable spores (> 7 log CFU/mg) and they maintained viability
during electrospinning and 6 months of storage at room temperature. Spores were
rapidly released from PEO nanofibers, while presence of alginate in the nanofibers
prolonged their release. All formulations exhibited swelling, followed by
transformation of the nanofiber mat into a hydrogel and polymer erosion mediating
spore release kinetics. The investigated Bacillus strains released metabolites,
which were not cytotoxic to peripheral blood mononuclear cells (PBMCs) in vitro.
Moreover, their metabolites exhibited antibacterial activity against two
periodontopathogens, an anti -proliferative effect on PBMCs, and inhibition of PBMC
expression of proinflammatory cytokines. In summary, the developed nanofiber-based
delivery system represents a promising therapeutic approach to combat biofilm-
associated disease on two fronts, namely via modulation of the local microbiota
with probiotic bacteria and host immune response with their metabolites.
AN - rayyan-563562351
AU - Grilc, N. K.
AU - Zidar, A.
AU - Kocbek, P.
AU - Rijavec, T.
AU - Colja, T.
AU - Lapanje, A.
AU - Jeras, M.
AU - Gobec, M.
AU - Mlinaric-Rascan, I.
AU - Gasperlin, M.
AU - Kristl, J.
AU - Zupanc, S.
DO - 10.1016/j.jconrel.2023.01.082
PY - 2023
SN - ["0168-3659", "1873-4995"]
SP - 371-384
T2 - JOURNAL OF CONTROLLED RELEASE
VL - 355
Y2 - 3
ID - 15725
ER -
TY - JOUR
periodontopathogens, an antiproliferative effect on PBMCs, and inhibition of PBMC
AN - rayyan-563559743
AU - Grilc, N. K.
AU - Zidar, A.
AU - Kocbek, P.
AU - Rijavec, T.
AU - Colja, T.
AU - Lapanje, A.
AU - Jeras, M.
AU - Gobec, M.
AU - Gašperlin, M.
AU - Kristl, J.
AU - Zupančič
DO - 10.1016/j.jconrel.2023.01.082
KW - anaerobic chamber
genetic analyzer
microscope
serum-free medium
spectrophotometer
alginic acid
antiinfective agent
gamma interferon
hydrogel
interleukin 17
interleukin 17F
interleukin 2
interleukin 6
macrogol
nanofiber
probiotic agent
virulence factor
article
Bacillus
bacterial genome
bacterial spore
bacterial strain
bacterial viability
colony forming unit
controlled study
cytokine production
cytotoxicity
dispersion
drug formulation
human
immunomodulation
in vitro study
mouth flora
nonhuman
periodontitis
whole genome sequencing
LA - English
PY - 2023
SN - ["1873-4995", "0168-3659"]
SP - 371-384
T2 - J. Control. Release
VL - 355
ID - 13117
ER -
TY - JOUR
periodontopathogens, an antiproliferative effect on PBMCs, and inhibition of PBMC
AN - rayyan-563560963
AU - Grilc, N. K.
AU - Zidar, A.
AU - Kocbek, P.
AU - Rijavec, T.
AU - Colja, T.
AU - Lapanje, A.
AU - Jeras, M.
AU - Gobec, M.
AU - Gašperlin, M.
AU - Kristl, J.
AU - Zupančič, Š
DO - 10.1016/j.jconrel.2023.01.082
J2 - J Control Release
KW - Humans
*Nanofibers
Leukocytes, Mononuclear
*Bacillus/genetics
Polyethylene Glycols
Alginates
LA - eng
N1 - Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000
Ljubljana, Slovenia.; Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta
7, 1000 Ljubljana, Slovenia.; Faculty of Pharmacy, University of Ljubljana,
Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.; Department of Environmental Sciences,
Institut "Jožef Stefan", Jamova cesta 39, 1000 Ljubljana, Slovenia.; Department of
Environmental Sciences, Institut "Jožef Stefan", Jamova cesta 39, 1000 Ljubljana,
Slovenia.; Department of Environmental Sciences, Institut "Jožef Stefan", Jamova
cesta 39, 1000 Ljubljana, Slovenia.; Faculty of Pharmacy, University of Ljubljana,
Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.; Faculty of Pharmacy, University of
Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.; Faculty of Pharmacy,
University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.; Faculty of
Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.;
Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana,
Slovenia. Electronic address: julijana.kristl@ffa.uni-lj.si.; Faculty of Pharmacy,
University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia. Electronic
address: spela.zupancic@ffa.uni-lj.si.
PY - 2023
SP - 371-384
T2 - Journal of controlled release : official journal of the Controlled Release
Society
VL - 355
Y2 - 3
ID - 14337
ER -
TY - JOUR
AB - A subantimicrobial dose of doxycycline is the only host response modifying,
systemic therapy currently available for the treatment of periodontal disease. The
purpose of this study was to develop and characterize a controlled-release delivery
system of subantimicrobial dose doxycycline hyclate. Sustained release matrix
tablets of doxycycline hyclate were developed using hydroxypropyl cellulose. The
rate of doxycycline release from tablets was tested, erosion studies performed and
the strength of the outer gel layer measured. The drug release mechanism was
characterized using the combined data from the dissolution and erosion studies. The
formulations studied were comprised from mixtures ofhydrophilic polymers
(hydroxypropyl cellulose) of high and low molecular weights in different ratios and
in some cases contained a fraction of hydrophobic polymer. We found that the ratio
of high molecular weight hydrophilic polymer content to low molecular weight
hydrophilic polymer content determined whether the erosion process was the main
mechanism governing drug release. In addition, we found that erosion constant value
implied the governing release mechanism, since there was a 4-fold difference
between erosion constant values in two different release mechanisms.
AN - rayyan-563560672
AU - Grin, A.
AU - Moor, E.
AU - Friedman, M.
DO - 10.1016/S1773-2247(09)50055-X
IS - 4
matrix metalloproteinase inhibitor
article
chronic disease
drug solubility
in vitro study
molecular weight
periodontal disease
tablet formulation
tablet hardness
LA - English
PY - 2009
SN - 1773-2247
SP - 295-300
ST - Sustained release of doxycycline as matrix metalloproteinase inhibitor for
treatment of chronic periodontal diseases: In vitro evaluation
TI - Sustained release of doxycycline as matrix metalloproteinase inhibitor for
treatment of chronic periodontal diseases: In vitro evaluation
VL - 19
ID - 14046
ER -
TY - JOUR
AB - Background and Aim: Porphyromonas gingivalis (P. gingivalis), a known
pathogen in periodontitis, invades host cells and expresses numerous virulence
factors. Fimbriae are involved in colonization, invasion and persistence owf
bacteria inside the host cells and may affect host immune-response mechanisms that
are responsible for bacterial elimination. P. gingivalis fimbriae are essential in
initial cell attachment and bacterial internalization into gingival epithelial
cells. The major fimbriae, coded by the FimA gene, are able to bind specifically to
different host cells, amongst them human epithelial cells and monocytes. The aim of
this study was to generate and characterize the properties of a recombinant P.
gingivalis W83 FimA. Methods: The FimA gene was cloned in Listeria innocua using
the vector Pimk2sph His-N. The Protein was purified using fast protein liquid
chromatography (FPLC) and characterized by sodium dodecyl sulfate polyacrylamide
gel electrophoresis (SDS PAGE) and mass spectrometry. The biological activity was
shown by stimulation of primary and immortalized human gingival keratinocytes
(PHGK, IHGK), SCC-25 cells and human monocytes. After 24 h FimA supernatants were
harvested and the cytokines IL-12p70, TNF, IL-10 IL-6, IL-8, IL-1β were quantified
using the human inflammatory cytokine cytometric bead array (CBA) kit (BD) and
analyzed by flow cytometry. Results: Pure fractions of the FimA protein were
sequenced and identified and used for the proof of biological activity. Human oral
epithelial cells did not induce cytokine production upon stimulation. In contrast,
monocytes reacted with production of inflammatory cytokines i.e. TNF, IL-10, IL-6
and IL-1β in high concentrations in the cell supernatant. Conclusions: Our results
demonstrate, that human monocytes react by inducing high-level productions of
cytokines to recombinant P. gingivalis W83 FimA. Further studies are required to
study the mechanisms underlying this induction and for determining those features
of FimA that lead to this induction.
AN - rayyan-563559842
AU - Groeger, S.
AU - Domann, E.
AU - Chakraborty, T.
AU - Ruf, S.
AU - Meyle, J.
DO - 10.1111/jcpe.13634
KW - cytokine
endogenous compound
interleukin 10
interleukin 12p70
interleukin 1beta
interleukin 6
interleukin 8
biological activity
conference abstract
controlled study
cytokine production
cytometric bead array
fimbria
gingiva
host cell
human
human cell
keratinocyte
Listeria innocua
male
mass spectrometry
monocyte
nonhuman
supernatant
LA - English
PY - 2022
SN - 1600-051X
SP - 52-53
ST - Generation and characterization of recombinant Porphyromonas gingivalis W83
FimA
TI - Generation and characterization of recombinant Porphyromonas gingivalis W83
FimA
VL - 49
ID - 13216
ER -
TY - JOUR
AB - Porphyromonas gingivalis (P. gingivalis) is regarded as a keystone pathogen
in destructive periodontal diseases. It expresses a variety of virulence factors,
amongst them fimbriae that are involved in colonization, invasion, establishment
and persistence of the bacteria inside the host cells. The fimbriae also were
demonstrated to affect the host immune-response mechanisms. The major fimbriae are
able to bind specifically to different host cells, amongst them peripheral blood
monocytes. The interaction of these cells with fimbriae induces release of
cytokines such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor-α (TNF-α).
The aim of this study was to generate recombinant major FimA protein from P.
gingivalis W83 fimbriae and to prove its biological activity. FimA of P. gingivalis
W83 was amplified from chromosomal DNA, cloned in a vector and transferred into
Listeria innocua. (L. innocua).The expressed protein was harvested and purified
using FPLC via a His trap HP column. The identity and purity was demonstrated by
gel-electrophoresis and mass-spectrometry. The biological activity was assessed by
stimulation of human oral epithelial cells and peripheral blood monocytes with the
protein and afterwards cytokines in the supernatants were quantified by enzyme
linked immunosorbent assay (ELISA) and cytometric bead array. Recombinant FimA
could successfully be generated and purified. Gel-electrophoresis and mass-
spectrometry confirmed that the detected sequences are identical with FimA.
Stimulation of human monocytes induced the release of high concentrations of IL-1β,
IL-6, IL-10 and TNF-α by these cells. In conclusion, a recombinant FimA protein was
established and its biological activity was proven. This protein may serve as a
promising agent for further investigation of its role in periodontitis and possible
new therapeutic approaches.
AN - rayyan-563559942
AU - Groeger, S.
AU - Hudel, M.
AU - Zechel, S.
AU - Chakraborty, T.
AU - Lochnit, G.
AU - Meyle, J.
AU - Domann, E.
DO - 10.1016/j.jbiotec.2021.08.009
KW - culture medium
ELISA kit
flow cytometer
hollow fiber
bacterial protein
fimA protein
interleukin 10
interleukin 12p70
interleukin 1beta
interleukin 6
unclassified drug
amino acid sequence
article
controlled study
cytometric bead array
Escherichia coli
fast protein liquid chromatography
gel electrophoresis
human
human cell
immune response
Listeria innocua
mass spectrometry
molecular weight
monocyte
nonhuman
periodontitis
protein expression
protein function
protein isolation
LA - English
PY - 2021
SN - ["1873-4863", "0168-1656"]
SP - 22-29
ST - Generation and functional characterization of recombinant Porphyromonas
gingivalis W83 FimA
T2 - J. Biotechnol.
TI - Generation and functional characterization of recombinant Porphyromonas
gingivalis W83 FimA
VL - 340
ID - 13316
ER -
TY - JOUR
AB - Chronic inflammation is known to contribute to various human cancers.
Porphyromonas gingivalis (P. gingivalis), is a gram-negative oral keystone pathogen
that may cause severe periodontitis and expresses several virulence factors to
affect the host immune system. Periodontitis is a chronic infectious disease that
while progression, may cause loss of attachment and destruction of the tooth
supporting tissues. Prostate cancer is one of the most common malignancies in men.
Increasing evidence links periodontitis with prostate cancer, however the
mechanisms explaining this relationship remain unclear. The aim of this study was
to investigate the expression and signaling pathway of programmed death ligand 1
(PD-L1) in a prostate cancer cell line after infection with P. gingivalis and
stimulation with P. gingivalis components to reveal the mechanism of tumor-induced
immune evasion associated with bacterial infection in the tumor environment.
Prostate cancer cells were infected with different concentrations of viable P.
gingivalis and treated with different concentrations of heat-killed P. gingivalis
and P. gingivalis cell components, including the total membrane fraction, inner
membrane fraction, outer membrane fraction, cytosolic fraction and peptidoglycan
(PGN). Chemical inhibitors were used to block different important molecules of
signaling pathways to assess the participating signal transduction mechanisms. PD-
L1 expression was detected by Western blot after 24 h of infection. PD-L1 was
demonstrated to be upregulated in prostate cancer cells after infection with viable
and with heat-killed P. gingivalis membrane fractions. Also isolated PGN induced
PD-L1 up-regulation. The upregulation was mediated by the NOD1/NOD2 signaling
pathway. No upregulation could be detected after treatment of the cells with P.
gingivalis lipopolysaccharide (LPS). These results indicate, that chronic
inflammatory disease can contribute to tumor immune evasion by modifying the tumor
microenvironment. Thus, chronic infection possibly plays an essential role in the
immune response and may promote the development and progression of prostate cancer.
AN - rayyan-563559830
AU - Groeger, S.
AU - Wu, F.
AU - Wagenlehner, F.
AU - Dansranjav, T.
AU - Ruf, S.
AU - Denter, F.
AU - Meyle, J.
DO - 10.3389/fcimb.2022.935806
KW - nucleic acid isolation kit
Nucleo Spin
PCR assay kit
Protein Assay Kit
SensiFAST
X ray film
caspase recruitment domain protein 15
CD 274 antigen
gamma interferon
gefitinib
lauroyl g d glutamyl meso diaminopimelic acid
messenger RNA
peptidoglycan
programmed death 1 ligand 1
sp 00125
sp 00125 inhibitor
toll like receptor
unclassified drug
anammox organism
antigen detection
article
bacterial growth
bacterial infection
cell stimulation
chemiluminescence immunoassay
controlled study
cytosolic fraction
DU145 cell line
epithelium cell
exponential growth phase
high pressure cell disruption
host immunity
human
human cell
hyperactivated T effector cell
immune evasion
immune response
inflammation
membrane fraction
multiplicity of infection
periodontitis
Porphyromonas gingivalis W83
prostate cancer
prostate cancer cell line
protein content
protein determination
protein expression
receptor upregulation
signal transduction
spectrophotometry
tooth supporting tissue
Treponema denticola
ultracentrifugation
Western blotting
LA - English
PY - 2022
SN - 2235-2988
ST - PD-L1 Up-Regulation in Prostate Cancer Cells by Porphyromonas gingivalis
TI - PD-L1 Up-Regulation in Prostate Cancer Cells by Porphyromonas gingivalis
VL - 12
ID - 13204
ER -
TY - JOUR
AB - Concentrations and output of lactoferrin and of low-Mr mucin MG2 were
determined in saliva of subjects suffering from Actinobacillus
actinomycetemcomitans-associated periodontal disease and healthy subjects.
Periodontal patients were clinically examined and a microbiological sample was
taken from the deepest bleeding pockets in each quadrant. The number of viable A.
actinomycetemcomitans was determined in the sampled sites of each patient. The MG2
output in the diseased subjects (13.6 microg protein/min) was decreased at least by
a factor three compared to periodontal healthy subjects (44.3 microg protein/min).
On the other hand, output of lactoferrin was not significantly different in healthy
(9.5 microg/min) and diseased subjects (7.6 microg/min). Western analyses
demonstrated a higher iron-saturation of lactoferrin in diseased subjects in
comparison with the healthy subjects. Lactoferrin degrading enzymes, probably
derived from microbial sources, could be detected in saliva of the periodontally
diseased subjects, but not in saliva of healthy subjects. The combination of iron-
saturation and degradation of lactoferrin suggests that anti-microbial properties
of lactoferrin are diminished in periodontitis patients. Moreover, the low
concentration of mucin MG2 suggests a decline in mucin defence and consequently a
higher susceptibility for oral infection. A negative correlation (r= -0.4, p <
0.05) between the number of subgingival A. actinomycetemcomitans and lactoferrin in
saliva suggested that low concentrations of lactoferrin favour the growth of the
bacterium. These data indicate that a decline in the salivary defence system might
increase the risk for oral infection by A. actinomycetemcomitans.
AN - rayyan-563561008
AU - Groenink, J.
AU - Walgreen-Weterings, E.
AU - Nazmi, K.
AU - Bolscher, J. G.
AU - Veerman, E. C.
AU - van Winkelhoff, A. J.
AU - Nieuw Amerongen, A. V.
IS - 5
KW - albuminoid
cystatin
iron
lactoferrin
MUC7 protein, human
mucin
saliva protein
adolescent
adult
article
bacterial count
bacterial infection
chemistry
comparative study
female
human
immunoblotting
male
metabolism
microbiology
middle aged
periodontitis
risk factor
saliva
Western blotting
LA - English
PY - 1999
SN - 0303-6979
SP - 269-275
ST - Salivary lactoferrin and low-Mr mucin MG2 in Actinobacillus
actinomycetemcomitans-associated periodontitis
TI - Salivary lactoferrin and low-Mr mucin MG2 in Actinobacillus
VL - 26
ID - 14382
ER -
TY - COMP
AB - Concentrations and output of lactoferrin and of low-Mr mucin MG2 were
determined in saliva of subjects suffering from Actinobacillus
actinomycetemcomitans-associated periodontal disease and healthy subjects.
Periodontal patients were clinically examined and a microbiological sample was
taken from the deepest bleeding pockets in each quadrant. The number of viable A.
actinomycetemcomitans was determined in the sampled sites of each patient. The MG2
output in the diseased subjects (13.6 microg protein/min) was decreased at least by
a factor three compared to periodontal healthy subjects (44.3 microg protein/min).
On the other hand, output of lactoferrin was not significantly different in healthy
(9.5 microg/min) and diseased subjects (7.6 microg/min). Western analyses
demonstrated a higher iron-saturation of lactoferrin in diseased subjects in
comparison with the healthy subjects. Lactoferrin degrading enzymes, probably
derived from microbial sources, could be detected in saliva of the periodontally
diseased subjects, but not in saliva of healthy subjects. The combination of iron-
saturation and degradation of lactoferrin suggests that anti-microbial properties
of lactoferrin are diminished in periodontitis patients. Moreover, the low
concentration of mucin MG2 suggests a decline in mucin defence and consequently a
higher susceptibility for oral infection. A negative correlation (r= -0.4, p <
0.05) between the number of subgingival A. actinomycetemcomitans and lactoferrin in
saliva suggested that low concentrations of lactoferrin favour the growth of the
bacterium. These data indicate that a decline in the salivary defence system might
increase the risk for oral infection by A. actinomycetemcomitans.
AN - rayyan-563561394
AU - Groenink, J.
AU - Walgreen-Weterings, E.
AU - Nazmi, K.
AU - Bolscher, J. G.
AU - Veerman, E. C.
AU - van Winkelhoff, A. J.
AU - Nieuw Amerongen, A. V.
CY - United States
DO - 10.1034/j.1600-051x.1999.260501.x
ET - 5
KW - Actinobacillus Infections/*metabolism
Adolescent
Adult
*Aggregatibacter actinomycetemcomitans/growth & development
Albumins/analysis
Blotting, Western
Colony Count, Microbial
Cystatins/analysis
Cysteine Proteinase Inhibitors/analysis
Female
Humans
Immunoblotting
Iron/analysis
Lactoferrin/*analysis
Male
Middle Aged
Mucins/*analysis
Periodontal Pocket/microbiology
Periodontitis/*microbiology
Risk Factors
Saliva/*chemistry/microbiology
Salivary Proteins and Peptides/*analysis
LA - eng
N1 - Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam
(ACTA), The Netherlands. J.Groenink.obc.acta@med.vu.nl
PY - 1999
SN - 0303-6979 (Print)
SP - 269-75
ST - Salivary lactoferrin and low-Mr mucin MG2 in Actinobacillus
TI - Salivary lactoferrin and low-Mr mucin MG2 in Actinobacillus
VL - 26
Y2 - 5
ID - 14768
ER -
TY - JOUR
AN - rayyan-563561818
AU - Grover, H. S.
AU - Kapoor, S.
AU - Singh, A.
DO - 10.1016/j.jobcr.2015.11.003
IS - 2
PY - 2016
SP - 85-92
ST - Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid
interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis - A
clinicobiochemical study
T2 - Journal of Oral Biology and Craniofacial Research
TI - Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid
84969194705&doi=10.1016%2fj.jobcr.2015.11.003&partnerID=40&md5=928ddf25737fd768bc21
962920545d93
VL - 6
ID - 15192
ER -
TY - JOUR
AB - OBJECTIVES: The impact of simvastatin (SMV), a cholesterol lowering drug, on
bone metabolism appears to involve complex interaction with cholesterol
metabolites, hormones, inflammatory mediators and growth factors, thus having
direct influence on extent and severity of periodontitis. The present study aims to
evaluate the in vivo effect of subgingivally delivered SMV gel (1.2 mg) as a local
drug-delivery agent on clinical parameters and on interleukin-6 (IL-6),
interleukin-8 (IL-8) and interleukin-10 (IL-10) levels in gingival crevicular fluid
(GCF) of chronic periodontitis patients. MATERIALS AND METHODS: 50 patients were
selected and categorized into two treatment groups: control (scaling and root
planing) and test group (scaling and root planing with SMV gel). At initial
appointment, clinical parameters were measured. Biochemical analysis of GCF samples
was done to evaluate the amount of IL-6, IL-8 and IL-10. GCF sampling and clinical
parameters were repeated at one and three months for both the groups. RESULTS: SMV
has an inhibitory effect on pro-inflammatory cytokines (IL-6, IL-8) and stimulatory
effect on anti-inflammatory cytokines (IL-10) in GCF of periodontitis patients and
has significantly positive effect on all clinical parameters except relative
attachment level (RAL). The addition of SMV, thereby, further alters the levels of
cytokine that reflect enhanced antibacterial host defence activity at that site.
CONCLUSION: Topical SMV has a beneficial effect on periodontal health. Removal of
the bacterial plaque and subgingival delivery of SMV significantly modulates the
chemokines present in GCF. To summarize, SMV shows promising role in the management
of periodontitis.
AN - rayyan-563561360
AU - Grover, H. S.
AU - Kapoor, S.
AU - Singh, A.
DO - 10.1016/j.jobcr.2015.11.003
IS - 2
LA - eng
N1 - Professor & H.O.D., Department of Periodontics, SGT Dental College, Haryana,
India.; Assistant Professor, Department of Periodontics, SGT Dental College,
Haryana, India.; Postgraduate Student, Department of Periodontics, SGT Dental
College, Haryana, India.
PY - 2016
SN - 2212-4268 (Print)
SP - 85-92
ST - Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid
TI - Effect of topical simvastatin (1.2 mg) on gingival crevicular fluid
VL - 6
Y2 - 5
ID - 14734
ER -
TY - JOUR
AB - Emblica officinalis fruit possesses varied medicinal properties including
cytoprotective antimicrobial, antioxidant, antiresorptive and antiinflammatory
activity. The present study aimed to investigate the effect of subgingival
application of indigenously prepared E. officinalis (Amla) sustained-release gel
adjunctive to scaling and root planing (SRP) on chronic periodontitis. Forty-six
patients (528 sites) were randomly assigned to control group (23;264): SRP +placebo
gel and test group (23;264): SRP + 10% E. officinalis gel application. Periodontal
parameters: plaque index, gingival index, probing pocket depth (PPD), clinical
attachment level (CAL) and modified sulcus bleeding index (mSBI) were assessed at
baseline, 2 and 3-month post-therapy. Forty patients (470 sites) completed the
trial. When test and control sites were compared, significantly more reduction in
mean PPD, mSBI, number of sites with PPD = 5-6 mm, PPD ≥ 7 mm, CAL ≥ 6 mm and
greater CAL gain were achieved in test sites at 2- and 3-month post-therapy (p <
0.05). Locally delivered 10% E. officinalis sustained-release gel used as an
adjunct to SRP may be more effective in reducing inflammation and periodontal
destruction in patients with chronic periodontitis when compared with SRP alone.
AN - rayyan-563560342
AU - Grover, S.
AU - Tewari, S.
AU - Sharma, R. K.
AU - Singh, G.
AU - Yadav, A.
AU - Naula, S. C.
DO - 10.1002/ptr.5600
IS - 6
KW - Emblica officinalis extract
absence of side effects
article
clinical article
controlled study
drug efficacy
drug response
gel
gingival index
human
modified sulcus bleeding index
periodontics
tooth plaque
treatment duration
treatment outcome
LA - English
PY - 2016
SN - ["1099-1573", "0951-418X"]
SP - 956-962
ST - Effect of Subgingivally Delivered 10% Emblica officinalis Gel as an Adjunct
to Scaling and Root Planing in the Treatment of Chronic Periodontitis - A
Randomized Placebo-controlled Clinical Trial
TI - Effect of Subgingivally Delivered 10% Emblica officinalis Gel as an Adjunct
to Scaling and Root Planing in the Treatment of Chronic Periodontitis - A
Randomized Placebo-controlled Clinical Trial
VL - 30
ID - 13716
ER -
TY - JOUR
AB - The effects of dicloran gel in combination with antibiotics on salivary lipid
peroxidation were evaluated in 18 patients aged 23-68 years with chronic
generalized rapidly progressing periodontitis. Lipid peroxidation and activity of
antioxidant systems surpassed the normal values 2-4-fold in periodontitis patients
before treatment. After therapy with metrogil-dent these parameters decreased (p <
0.05). Injection of dicloran gel before antibiotic therapy induced a decrease in
these parameters within approximately 30 min. If dicloran gel was injected after
metrogil-dent, the maximum decrease in oxidative processes and antioxidant system
activity was observed as soon as in 15 min.
AN - rayyan-563560897
AU - Grudianov, A. I.
AU - Ovchinnikova, V. V.
AU - Serebriakova, L. E.
IS - 4
KW - aniline derivative
antiinfective agent
dicloran
metronidazole
adult
aged
article
chronic disease
drug combination
drug effect
evaluation study
female
gel
human
lipid peroxidation
male
metabolism
middle aged
periodontitis
saliva
LA - Russian
PY - 2002
SN - 0039-1735
SP - 31-34
ST - Relationship between salivary lipid peroxidation and the strategy of local
dichloran gel treatment for periodontitis
T2 - Zavisimost' pokazatelei perekisnogo okisleniia v sliune ot taktiki lokal'nogo
primenenia dikloran-zhele pri parodontite.
TI - Relationship between salivary lipid peroxidation and the strategy of local
dichloran gel treatment for periodontitis
VL - 81
ID - 14271
ER -
TY - JOUR
AB - BACKGROUND: It is important to institute an effective supportive therapy to
maintain or recover soft tissue health around dental implants. Different
maintenance regimens have been suggested, however it is unclear which are the most
effective. OBJECTIVES: To assess the effects of different interventions for 1)
maintaining and 2) recovering soft tissue health around osseointegrated dental
implants. SEARCH STRATEGY: We searched the Cochrane Oral Health Group's Trials
Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and
EMBASE. Handsearching included several dental journals. We checked the
bibliographies of the identified randomised controlled trials (RCTs) and relevant
review articles for studies outside the handsearched journals. We wrote to authors
of all identified RCTs, to more than 55 oral implant manufacturers and to an
Internet discussion group to find unpublished or ongoing RCTs. No language
restrictions were applied. The last electronic search was conducted on 2 June 2010.
SELECTION CRITERIA: All randomised controlled trials comparing agents or
interventions for maintaining or recovering healthy tissues around dental implants.
DATA COLLECTION AND ANALYSIS: Screening of eligible studies, assessment of the
methodological quality of the trials and data extraction were conducted in
duplicate and independently by two review authors. Results were expressed as
random-effects models using standardised mean differences for continuous data and
risk ratios for dichotomous data with 95% confidence intervals. MAIN RESULTS: Five
trials compared interventions for maintaining soft tissue health around implants
and a further six trials compared interventions to recover soft tissue health where
there was evidence of peri-implant mucositis. No statistically significant
differences were found between the effectiveness of powered versus manual
toothbrushes for either maintaining or recovering soft tissue health. There was no
statistically significant difference found between different types of self
administered antimicrobials for maintaining soft tissue health (hyaluronic acid gel
compared to chlorhexidine gel, amine fluoride/stannous fluoride mouthwash compared
to chlorhexidine mouthwash) and triclosan dentifrice compared to sodium fluoride
dentifrice showed no statistically significant difference in recovering soft tissue
health. However chlorhexidine irrigation was more effective in reducing plaque and
marginal bleeding scores compared to chlorhexidine mouthwash and Listerine
mouthwash was found to be statistically significantly better than placebo with
regard to reducing mean plaque scores and marginal bleeding scores. When
interventions administered by dental professional were compared there was no
statistically significant difference found between chlorhexidine and physiologic
solutions as irrigants at second stage surgery to maintain health of soft tissues.
In patients with peri-implant mucositis two trials evaluated interventions
performed by dental professionals. There was no statistically significant
difference between mechanical debridement followed by either minocycline or
chlorhexidine gel, or between debridement with a titanium curette compared to an
ultrasonic debridement tool. AUTHORS' CONCLUSIONS: There was only low quality
evidence for which are the most effective interventions for maintaining or
recovering health of peri-implant soft tissues. The included RCTs had short follow-
up periods and few subjects and although overall the risk of bias of the studies
was either low or unclear, only single trials were available for each outcome.
There was no reliable evidence as to which regimens are most effective for long
term maintenance. This should not be interpreted as meaning that current
maintenance regimens are ineffective. There was weak evidence that antibacterial
mouthrinses are effective in reducing plaque and marginal bleeding around implants.
More RCTs should be conducted in this area. In particular, there is a definite need
for trials powered to find possible differences, usin primary outcome measures and
with much longer follow up. Such trials should be reported according to the CONSORT
guidelines (www.consort-statement.org/).
AN - rayyan-563560630
AU - Coulthard, P.
AU - George, P.
AU - Esposito, M.
KW - adult
gingiva disease
human
devices
meta analysis
methodology
mouth hygiene
periodontal disease
review
tooth implantation
LA - English
PY - 2010
SN - 1469-493X
SP - CD003069
ST - Interventions for replacing missing teeth: maintaining and recovering soft
tissue health around dental implants
T2 - Cochrane Database Syst Rev
TI - Interventions for replacing missing teeth: maintaining and recovering soft
tissue health around dental implants
VL - 8
ID - 14004
ER -
TY - JOUR
AB - Aim: To compare the clinical and microbiological effects of ultrasonic
mechanical instrumentation (UMI) associated to home-care use of amine
fluoride/stannous fluoride (AmF/SnF2)-containing mouthrinse and toothpaste in
smoker and non-smoker patients affected by generalized aggressive periodontitis (G-
AgP) during a recall session of supportive periodontal therapy (SPT). Material and
Methods: Thirteen smokers and 25 non-smokers G-AgP patients enrolled in an SPT
programme received a single session of UMI associated with home-care use of
AmF/SnF2-containing mouthrinse and toothpaste. Clinical and microbiological
parameters were assessed pre-treatment, at 6 and 12 weeks post-treatment. Results:
In both groups, UMI plus AmF/SnF 2-implemented oral hygiene use determined a
significant decrease of total bacterial counts, with non-smokers exhibiting a lower
count compared with smokers at 12 weeks. No significant differences were observed
between smokers and non-smokers in the counts of total pathogens and red complex
species at each observation interval. Clinically, a significant reduction of
supragingival plaque, gingival inflammation and probing pocket depth was similarly
observed in both groups. Conclusions: A combined mechanical/chemical plaque control
approach based on UMI and the use of AmF/SnF2 agents resulted in the reduction of
supragingival plaque deposits, gingival inflammation and subgingival periodontal
pathogens in G-AgP patients during SPT, with no substantial difference between
smokers and non-smokers. © 2010 John Wiley & Sons A/S.
AN - rayyan-563560624
AU - Guarnelli, M. E.
AU - Farina, R.
AU - Cucchi, A.
AU - Trombelli, L.
DO - 10.1111/j.1600-051X.2010.01623.x
IS - 11
KW - amine
amine fluoride gel
amine fluoride solution
sodium fluoride
fluoride varnish
mouthwash
tin fluoride
toothpaste
adult
article
bacterial count
chemistry
clinical trial
comparative study
controlled study
female
gingivitis
human
male
methodology
microbiology
nonparametric test
periodontics
smoking
tooth plaque
ultrasound
LA - English
PY - 2010
SN - ["0303-6979", "1600-051X"]
SP - 998-1004
ST - Clinical and microbiological effects of mechanical instrumentation and local
antimicrobials during periodontal supportive therapy in aggressive periodontitis
patients: Smoker versus non-smoker patients
TI - Clinical and microbiological effects of mechanical instrumentation and local
antimicrobials during periodontal supportive therapy in aggressive periodontitis
patients: Smoker versus non-smoker patients
VL - 37
ID - 13998
ER -
TY - JOUR
AB - AIM: The present study was carried out to evaluate the effect of 1.2%
simvastatin gel as local drug delivery (LDD) system on Gingival Crevicular Fluid
(GCF) Interleukin -6 (IL-6) and Interleukin-8 (IL-8) levels in chronic
periodontitis patients, in addition to scaling and root planing (SRP). METHODS: A
total of 46 chronic periodontitis patients were equally divided into two groups.
Group I patients were treated by SRP; Group II patients were treated by SRP
followed by LDD of 1.2% simvastatin (SMV) gel. Plaque index (PI), Gingival
index(GI), Sulcus Bleeding Index (SBI), Probing pocket depth (PPD) and Relative
clinical attachment level (CAL) were recorded & GCF samples were collected at
baseline (0day) and at 45th day from both the groups. The collected GCF samples
were analysed for IL-6 and IL-8 levels with enzyme-linked immunosorbent assay
(ELISA). RESULTS: Both the groups showed significant reduction in all the clinical
parameters scores and IL-6 and IL-8 levels after non-surgical periodontal therapy
(SRP for group I/SRP+1.2% SMV gel for group II) in contrast to baseline values.
However, a greater reduction was observed in group II. A non-significant positive
correlation was observed between clinical parameters and IL-6 and IL-8 levels
except at baseline, a significant correlation was observed between PPD &IL 6 levels
in group II. CONCLUSIONS: In adjunct to SRP, 1.2% Simvastatin gel acts as an
effective local drug delivery agent for the management of chronic periodontitis.
AN - rayyan-563560288
AU - Gunjiganur Vemanaradhya, G.
AU - Emani, S.
AU - Mehta, D. S.
AU - Bhandari, S.
DO - 10.1016/j.archoralbio.2017.05.022
KW - hydroxymethylglutaryl coenzyme A reductase inhibitor
interleukin 6
interleukin 8
simvastatin
adult
chemistry
controlled study
dental scaling
female
gel
gingivitis
human
male
metabolism
middle aged
periodontal index
root planing
treatment outcome
LA - English
PY - 2017
SN - 1879-1506
SP - 55-61
ST - Effect of 1.2% of simvastatin gel as a local drug delivery system on Gingival
Crevicular Fluid interleukin-6 & interleukin-8 levels in non surgical treatment of
chronic periodontitis patients
TI - Effect of 1.2% of simvastatin gel as a local drug delivery system on Gingival
Crevicular Fluid interleukin-6 & interleukin-8 levels in non surgical treatment of
VL - 82
ID - 13662
ER -
TY - JOUR
AB - Background: A number of studies in patients with periodontitis have compared
scaling and root planning (SRP) combined with an adjunctive treatment to SRP alone.
Within that literature, an array of studies with overlapping investigators has
consistently yielded substantially greater effects of adjunctive treatments than
had been previously noted. This report investigates discrepancies between that
cluster of research and the most recent American Dental Association (ADA)
systematic review. Methods: This review was preregistered at . A search using the
Scopus platform identified 32 articles published from 2010 to 2017 by investigators
affiliated with the Government Dental College and Research Institute (GDCRI) in
Bangalore, India. The primary outcome used in this meta-analysis was the change in
clinical attachment level (CAL) after 6 mo. Effect sizes were estimated using
Comprehensive Meta-Analysis software after categorizing agents into groups based on
pharmacologic similarity. Results: The search identified 32 studies encompassing 5
sets of adjunctive agents. Across the GDCRI studies, the CAL averaged 1.67 mm (95%
confidence interval [CI]: 1.43-1.91 mm), substantially exceeding values reported in
the ADA review (mean: 0.39 mm, 95% CI: 0.27-0.51 mm). For categories of studies in
which comparable subgroup estimates were available, the evaluations yielded
overlapping estimates of SRP alone, but CAL estimates were discrepant for both
locally delivered antimicrobials (GDCRI studies: mean: 1.45 mm, 95% CI: 0.63-2.27
mm; ADA review: mean: 0.38 mm, 95% CI: 0.16 -0.60 mm) and systemic antibiotics
(GDCRI studies: mean: 1.35 mm, 95% CI: 0.97-1.73 mm; ADA review: mean: 0.39 mm, 95%
CI: 0.21-0.57 mm). Conclusion: In the literature on adjunctive agents supplementing
SRP, findings from investigators linked to GDCRI stand out as having significantly
more favorable estimated effects. Meanwhile, some agents studied by GDCRI-linked
investigators have not been investigated by other researchers. In the absence of a
clear explanation for discrepant results, it is recommended that unusually
favorable reported effects of adjunctive agents be viewed with caution. Knowledge
Transfer Statement: The present meta-analysis observed an unusually large effect
size of adjunctive agents to scaling and root planning in studies conducted by the
same research group. These results were not consistent with trials on adjunctive
agents and previous reports. As this research group has exclusively tested most of
the agents, their results must be viewed with caution until other independent
groups replicate the studies and reproduce the effect size.
AN - rayyan-563562442
AU - Gunsolley, J. C.
AU - Al-Abedalla, K.
AU - Shaqman, M.
AU - Ioannidou, E.
DO - 10.1177/23800844211039722
IS - 3
PY - 2022
SN - ["2380-0844", "2380-0852"]
SP - 234-241
ST - Unusual Findings in Trials Evaluating Adjuncts to Scaling and Root Planing:
Meta-analysis (Part 1)
T2 - JDR CLINICAL & TRANSLATIONAL RESEARCH
TI - Unusual Findings in Trials Evaluating Adjuncts to Scaling and Root Planing:
Meta-analysis (Part 1)
VL - 7
Y2 - 7
ID - 15816
ER -
TY - JOUR
AB - Currently available drug delivery systems for oral diseases suffer from short
retention time and poor local concentrations at the target site. A biodegradable
stimulus-responsive hydrogel was synthesized in the present study to evaluate its
application as an environmentally sensitive carrier for on-demand intraoral drug
delivery. The hydrogel was synthesized from diacrylate-containing polyethylene
glycol-based scaffolds and a cysteine-terminated peptide crosslinker (CGPQG↓IWGQC)
via a Michael-type addition reaction. Because CGPQG↓IWGQC can be cleaved by matrix
metalloproteinase 8 (MMP-8), minocycline hydrochloride, bovine serum albumin, or an
antibacterial peptide (KSL) was incorporated into the scaffolds to evaluate the
MMP-8-responsive release behavior of the on-demand drug delivery system. Hydrogel
characterization and gelation kinetics were examined with gel time, Fourier-
transform infrared spectroscopy, scanning electron microscopy, and measurements of
rheologic parameters. Degradation behavior and MMP-8-responsive drug release were
performed by high-performance liquid chromatography and protein-specific assay.
Biocompatibility evaluation indicated that the hydrogels were noncytotoxic.
Antibacterial testing demonstrated that the released drugs were able to maintain
bioactivity. Taken together, these results suggest that the MMP-8-sensitive
hydrogel is a promising candidate for on-demand intraoral localized drug delivery.
Because MMP-8 is one of the most important biomarkers for periodontitis, the MMP-8-
responsive hydrogel has potential to be used for in situ adaptive degradation in
response to chronic periodontitis and peri-implantitis. This notion has to be
tested in animal models of periodontal disease.
AN - rayyan-563560193
AU - Guo, J.
AU - Sun, H.
AU - Lei, W.
AU - Tang, Y.
AU - Hong, S.
AU - Yang, H.
AU - Tay, F. R.
AU - Huang, C.
DO - 10.1177/0022034519831931
IS - 5
animal model
article
biocompatibility
biological activity
controlled study
cross linking
drug release
gelation
hydrogel
kinetics
Michael addition
nonhuman
periimplantitis
stimulus
biological marker
endogenous compound
macrogol
minocycline
LA - English
PY - 2019
SN - 1544-0591
SP - 564-571
ST - MMP-8-Responsive Polyethylene Glycol Hydrogel for Intraoral Drug Delivery
T2 - J. Dent. Res.
TI - MMP-8-Responsive Polyethylene Glycol Hydrogel for Intraoral Drug Delivery
VL - 98
ID - 13567
ER -
TY - JOUR
AB - Mandibular defect becomes a prevalent maxillofacial disease resulting in
mandibular dysfunctions and huge psychological burdens to the patients. Considering
the routine presence of oral contaminations and aesthetic restoration of facial
structures, the current clinical treatments are however limited, incapable to
reconstruct the structural integrity and regeneration, spurring the need for cost-
effective mandibular tissue engineering. Hydrogel systems possess great merit for
mandibular reconstruction with precise involvement of cells and bioactive factors.
In this review, current clinical treatments and distinct mode(s) of mandible
formation and pathological resorption are summarized, followed by a review of
hydrogel-related mandibular tissue engineering, and an update on the advanced
fabrication of hydrogels with improved mechanical property, antibacterial ability,
injectable form, and 3D bioprinted hydrogel constructs. The exploration of advanced
hydrogel systems will lay down a solid foundation for a bright future with more
biocompatible, effective, and personalized treatment in mandibular reconstruction.
AN - rayyan-563559740
AU - Guo, J.
AU - Yao, H.
AU - Li, X.
AU - Chang, L.
AU - Wang, Z.
AU - Zhu, W.
AU - Su, Y.
AU - Qin, L.
AU - Xu, J.
DO - 10.1016/j.bioactmat.2022.08.001
hydrogel
liposome
molecular scaffold
polymer
polysaccharide
biocompatibility
bioprinting
bone conduction
bone defect
bone development
bone metabolism
bone metastasis
bone mineralization
bone regeneration
bone turnover
cell infiltration
cell interaction
cell therapy
cell viability
clinical article
human
human cell
human tissue
immune response
immunogenicity
mandible
mandible condyle
mandible reconstruction
mandibulectomy
mechanical stimulation
microarray analysis
osseointegration
ossification
osteomyelitis
osteoporosis
oxidative stress
periodontal disease
periodontitis
progenitor cell line
review
systematic review
tissue engineering
tissue regeneration
LA - English
PY - 2023
SN - 2452-199X
SP - 175-193
ST - Advanced Hydrogel systems for mandibular reconstruction
T2 - Bioact. Mater.
TI - Advanced Hydrogel systems for mandibular reconstruction
VL - 21
ID - 13114
ER -
TY - JOUR
AB - AIM: The aim of this study was to evaluate and compare the efficacy of
subgingivally delivered 10% doxycycline hyclate and xanthan based chlorhexidine
gels when used as an adjunct to scaling and root planing (SRP) in the treatment of
chronic periodontitis. METHODS AND MATERIALS: A randomized, controlled, single
center study was conducted involving 90 sites in 30 patients suffering from
moderate to advanced chronic periodontitis. Each patient contributed three sites
which were randomized to three treatment groups: SRP + insertion of doxycycline gel
[SRP+DH], SRP + insertion of chlorhexidine gel [SRP+CHX]), and SRP alone [SRP].
Gingival index (GI), plaque index (PI), probing pocket depth (PPD), and clinical
attachment level (CAL) were recorded at baseline, 1 month, and 3 months post
therapy. RESULTS: All treatments showed significant reductions in PPD and CAL at 1
and 3 months when compared to baseline values (p<0.001). At 3 months, sites treated
with SRP+DH and SRP+CHX showed an additional reduction in PPD of 0.86 +/- 1.0 mm
and 0.66 +/- 1.58 mm, respectively, significantly greater than SRP alone (p<0.02).
Differences in mean PPD reduction between SRP+DH and SRP+CHX were not significant
(p=0.46). At 3 months, differences in relative CAL between both SRP+DH (0.80 +/-
0.92) and SRP+CHX (0.63 +/- 1.47) and SRP alone were statistically significant
(p<0.02). Differences in relative CAL between SRP+DH and SRP+CHX were not
significant (p=0.54). CONCLUSION: The results suggest treatment with 10%
doxycycline hyclate and xanthan based chlorhexidine gels as an adjunct to SRP
improves PPD and CAL patients with periodontitis compared to SRP alone. CLINICAL
SIGNIFICANCE: The use of local drug therapy may refocus the need for surgical
periodontal therapy toward deeper pockets.
AN - rayyan-563560693
AU - Gupta, R.
AU - Pandit, N.
AU - Aggarwal, S.
AU - Verma, A.
IS - 7
KW - bacterial polysaccharide
chlorhexidine
doxycycline
doxycycline hyclate
drug carrier
drug derivative
xanthan
adult
aged
article
clinical trial
controlled study
female
gel
human
male
middle aged
periodontics
prospective study
tooth plaque
LA - English
PY - 2008
SN - 1526-3711
SP - 25-32
ST - Comparative evaluation of subgingivally delivered 10% doxycycline hyclate and
xanthan-based chlorhexidine gels in the treatment of chronic periodontitis
TI - Comparative evaluation of subgingivally delivered 10% doxycycline hyclate and
xanthan-based chlorhexidine gels in the treatment of chronic periodontitis
VL - 9
ID - 14067
ER -
TY - JOUR
AB - GCF is a serum transudate or inflammatory exudate that is derived from the
periodontal tissues and can be collected at the orifice or from within the gingival
crevice.(1) The potential diagnostic importance of gingival fluid was recognized
more than 60 years ago and serious investigation of the dynamics of GCF production
did not begin until the late 1950s with the reports of Brill and co-workers.(2,3)
The fluid component of GCF derives primarily from microvascular leakage. Additions
to the fluid volume are made from the intercellular fluid and cellular cytoplasm.
The gingival tissue is constantly subjected to mechanical and bacterial
aggregation.Resistance to these actions is provided by saliva, sulcular fluid,
epithelial surface keratinisation and initial stages of inflammation.(4) The
origin,composition and clinical significance of gingival crevicular fluid have
significantly helped us in understanding the pathogenesis of periodontal disease.
The need to find a non-invasive test method in periodontitis drew attention to the
sulcus fluid that is produced in small quantities even in a completely healthy
periodontium, and its composition is near similar to that of blood plasma.
AN - rayyan-563559923
AU - Gupta, S.
AU - Gupta, R.
AU - Sinha, S.
AU - Sharma, E.
AU - Mathur, A.
DO - 10.47750/pnr.2022.13.S09.097
KW - capillary tube
filter
filter strip
general device
micropipette
periotron
sampler
acid phosphatase
arylsulfatase
balanced salt solution
beta glucuronidase
biological marker
cathepsin B
cathepsin D
cathepsin G
chondroitin 4 sulfate
chondroitin 6 sulfate
collagen
collagen type 1
collagenase 3
dipeptidyl peptidase
elastase
fibronectin
glycosaminoglycan
heparin
hydroxyproline
immunoglobulin
immunoglobulin G
interleukin 1
interleukin 2
interleukin 4
interleukin 6
isotonic solution
lactoferrin
leukocyte elastase
lysozyme
methylcellulose
myeloperoxidase
osteocalcin
osteonectin
phosphoprotein
prostaglandin E
prostaglandin E2
telopeptide
tryptase
abscess
article
bacterium
cellular immunity
circadian rhythm
diagnostic accuracy
diagnostic test
diagnostic test accuracy study
epithelium
fluid flow
gingival tissue
gingival washing method
gingivitis
human
human tissue
humoral immunity
immunoassay
inflammation
keratinization
mass spectrometry
minimally invasive procedure
necrosis
neutrophil
non invasive procedure
osteolysis
pathogenesis
periodontal disease
periodontal pocket
procedures
saliva
sample
sulcular fluid
suppuration
tissue injury
volume
LA - English
PY - 2022
SN - ["2229-7723", "0976-9234"]
SP - 825-833
ST - Gingival Crevicular Fluid-An Eos of Biomarkers
T2 - J. Pharm. Negat. Results
TI - Gingival Crevicular Fluid-An Eos of Biomarkers
VL - 13
ID - 13297
ER -
TY - JOUR
AB - OBJECTIVES: Treatment of dental discolorations with external bleaching is
becoming very common in dentistry, however, possible irreversible alterations on
enamel surface due to bleaching procedures is a topic of discussion. The aim of
this study was to evaluate the clinical effects of bleaching by measuring the
dental plaque accumulation on human enamel and tooth discoloration in vivo. STUDY
DESIGN: Forty-four teeth in eleven patients not revealing any restorations or
periodontal problems were enrolled in this study. Bleaching agent applied only to
labial surfaces of incisors using commercial 35% hydrogen peroxide gel. Dental
plaque and tooth color measured in the same group of participants, at the end of
non-brushing periods lasting 3 and 5 days, respectively, before and after
bleaching. RESULTS: The results of the comparison of pre- and post-bleaching
measurements showed that, after a non-brushing period lasting 3 day, discoloration
scores and plaque accumulation scores for bleached surfaces were lower than the
non-bleached surface scores. However, at the end of a non-brushing period lasting 5
day, even the color measurement score in post-bleaching period was lower than the
pre-bleaching counterpart, plaque index measurements showed higher plaque
accumulation scores in the bleached group. CONCLUSIONS: According to these results,
bleaching with 35% hydrogen peroxide seem to favor plaque accumulation after non-
brushing period lasting 5 day and tooth discoloration after bleaching is not in
correlation with the amount of plaque accumulation.
AN - rayyan-563560714
AU - Gursoy, U. K.
AU - Eren, D. I.
AU - Bektas, O. O.
AU - Hurmuzlu, F.
AU - Bostanci, V.
AU - Ozdemir, H.
IS - 4
adult
article
female
human
male
tooth discoloration
tooth plaque
LA - English
PY - 2008
SN - 1698-6946
SP - E266-269
ST - Effect of external tooth bleaching on dental plaque accumulation and tooth
discoloration
T2 - Med Oral Patol Oral Cir Bucal
TI - Effect of external tooth bleaching on dental plaque accumulation and tooth
discoloration
VL - 13
ID - 14088
ER -
TY - JOUR
AB - Biopolysaccharides extracted from plants are mainly photosynthetic byproducts
found in leaves, pods, stems, fruits, grains, seeds, corms, rhizomes, roots, bark
exudates, and other plant parts. Recently, these plant-derived biopolysaccharides
have received a great deal of attention as pharmaceutical excipients in a range of
different dosage forms because of several key advantages, such as widespread
accessibility from nature as plant-based sources are readily available, sustainable
production, availability of easy and cost-effective extraction methodologies,
aqueous solubility, swelling capability in the aqueous medium, non-toxicity,
biodegradability, etc. The current review presents a comprehensive overview of the
uses of plant-derived biopolysaccharides as effective pharmaceutical excipients in
the formulations of different kinds of dosage forms, for example gels, pastes,
films, emulsions, suspensions, capsules, tablets, nanoparticles, microparticles,
beads, buccal formulations, transdermal formulations, ocular formulations, nasal
formulations, etc.
AN - rayyan-563559727
AU - Guru, P. R.
AU - Kar, R. K.
AU - Nayak, A. K.
AU - Mohapatra, S.
DO - 10.1016/j.ijbiomac.2023.123454
KW - albizia gum
algaroba
amphotericin B
amylopectin
Arrowroot starch
atenolol
cashew tree exudate gum
curcumin
diazepam
diclofenac
dillenia fruit gum
Dioscorea starch
doxorubicin
fluconazole
fluorouracil
gel
gentamicin
grewia gum
guar gum
gum arabic
gum cordia
gum ghatti
gum kondagogu
gum odina
gum tragacanth
honey locust gum
ibuprofen
indometacin
isoxsuprine
itraconazole
Jackfruit seed starch
ketoprofen
khaya gum
leucaena gum
lidocaine
metformin
metoprolol
metronidazole
midazolam
moringa gum
nanoparticle
ofloxacin
okra gum
oxytocin
pilocarpine
pioglitazone
piperine
plant gum
polysaccharide
potato starch
propranolol
rhodamine B
risperidone
rizatriptan
rofecoxib
sago
Sorghum starch
starch
tamarind gum
Tapioca starch
terminalia gum
Tiger nut starch
tolterodine
unclassified drug
Aloe mucilage
bacterial keratitis
Basella alba leaves and stem mucilage
Basil seed mucilage
biodegradability
cytotoxicity
emulsion
entrapment efficiency
ex vivo study
Fenugreek seed mucilage
fruit
grain
Hibiscus rosasinensis leaves mucilage
human
hydrophilicity
in vitro study
Linseed mucilage
MCF-7 cell line
MDA-MB-231 cell line
medicinal plant
Mimosa pudica seed mucilage
MTT assay
mucilage
mucoadhesion
Mycobacterium tuberculosis
nonhuman
particle size
paste
periodontitis
photosynthesis
physical parameters
plant leaf
plant seed
plant stem
pod
Psyllium husk mucilage
review
rhizome
Spinacia oleraceae leaves mucilage
Sterculia
suspension
tablet
water solubility
LA - English
PY - 2023
SN - ["1879-0003", "0141-8130"]
ST - A comprehensive review on pharmaceutical uses of plant-derived
biopolysaccharides
TI - A comprehensive review on pharmaceutical uses of plant-derived
biopolysaccharides
VL - 233
ID - 13101
ER -
TY - JOUR
AB - Context: Nanoparticles, owing to their smaller size, penetrate regions
inaccessible to other delivery systems, such as periodontal pockets. Thus, the
present study aimed to comparatively evaluate efficacy of 2% curcumin with
nanocarrier and 1% chlorhexidine gel as a local drug delivery (LDD) in the
treatment of periodontal pockets. Materials and Methods: Forty-five chronic
periodontitis patients with pocket depth 5-7 mm in two or more teeth were selected.
Full-mouth scaling and root planing (SRP) was done for all patients followed by
random allocation to the three treatment groups, namely SRP group (Group 1), 2%
curcumin with nanogel (Group 2), and 1% chlorhexidine gel (Group 3). Clinical
parameter assessment and microbiological analysis of subgingival plaque samples for
Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and
Tannerella forsythia (Tf) was done at baseline, 21st day, and 45th day. Results:
The results showed that when the two LDD agents were used as an adjunct to SRP in
chronic periodontitis, there was an improvement in all clinical parameters.
Evaluation of microbiological parameters also showed a significant reduction in Aa,
Pg, and Tf levels. Comparison of 2% turmeric extract with a nanocarrier system with
1% chlorhexidine gel showed that both the agents had a comparable antibacterial
effect on the three selected periodontopathic bacteria. Conclusion: The present
study showed that both the LDD agents showed an effective improvement of clinical
and microbiologic parameters. 2% curcumin delivered with a nanocarrier system
showed results comparable to chlorhexidine gel and hence shows promising future as
an LDD agent in the treatment of periodontal pockets.
AN - rayyan-563560124
AU - Guru, S. R.
AU - Adithya Reddy, K.
AU - Rao, R. J.
AU - Padmanabhan, S.
AU - Guru, R.
AU - Srinivasa, T. S.
DO - 10.4103/jisp.jisp_207_19
IS - 3
KW - CTRI/2017/09/009730
periodontal probe
chlorhexidine
curcumin
nanocarrier
nanogel
poloxamer
add on therapy
adult
article
clinical article
clinical assessment
clinical evaluation
clinical outcome
clinical protocol
comparative study
controlled study
dental scaling
drug efficacy
female
follow up
gingival index
human
male
nanopharmaceutics
periodontal pocket
plaque index
root planing
single drug dose
tooth plaque
LA - English
PY - 2020
SN - ["0975-1580", "0972-124X"]
SP - 244-252
ST - Comparative evaluation of 2% turmeric extract with nanocarrier and 1%
chlorhexidine gel as an adjunct to scaling and root planing in patients with
chronic periodontitis: A pilot randomized controlled clinical trial
TI - Comparative evaluation of 2% turmeric extract with nanocarrier and 1%
VL - 24
ID - 13498
ER -
TY - JOUR
AB - CONTEXT: Nanoparticles, owing to their smaller size, penetrate regions
inaccessible to other delivery systems, such as periodontal pockets. Thus, the
present study aimed to comparatively evaluate efficacy of 2% curcumin with
nanocarrier and 1% chlorhexidine gel as a local drug delivery (LDD) in the
treatment of periodontal pockets. MATERIALS AND METHODS: Forty-five chronic
periodontitis patients with pocket depth 5-7 mm in two or more teeth were selected.
Full-mouth scaling and root planing (SRP) was done for all patients followed by
random allocation to the three treatment groups, namely SRP group (Group 1), 2%
curcumin with nanogel (Group 2), and 1% chlorhexidine gel (Group 3). Clinical
parameter assessment and microbiological analysis of subgingival plaque samples for
Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and
Tannerella forsythia (Tf) was done at baseline, 21(st) day, and 45(th) day.
RESULTS: The results showed that when the two LDD agents were used as an adjunct to
SRP in chronic periodontitis, there was an improvement in all clinical parameters.
Evaluation of microbiological parameters also showed a significant reduction in Aa,
Pg, and Tf levels. Comparison of 2% turmeric extract with a nanocarrier system with
1% chlorhexidine gel showed that both the agents had a comparable antibacterial
effect on the three selected periodontopathic bacteria. CONCLUSION: The present
study showed that both the LDD agents showed an effective improvement of clinical
and microbiologic parameters. 2% curcumin delivered with a nanocarrier system
showed results comparable to chlorhexidine gel and hence shows promising future as
an LDD agent in the treatment of periodontal pockets.
AN - rayyan-563560972
AU - Guru, S. R.
AU - Reddy, K. A.
AU - Rao, R. J.
AU - Guru, R.
AU - Srinivasa, T. S.
DO - 10.4103/jisp.jisp_207_19
IS - 3
LA - eng
N1 - Department of Periodontology, Vydehi Institute of Dental Sciences and
Research Centre, Bengaluru, Karnataka, India.; Department of Periodontology, Vydehi
Institute of Dental Sciences and Research Centre, Bengaluru, Karnataka, India.;
Department of Periodontology, Bangalore Institute of Dental Science, Kalaburgi,
Karnataka, India.; Department of Periodontology, Vydehi Institute of Dental
Sciences and Research Centre, Bengaluru, Karnataka, India.; Department of
Prosthodontics, ESIC Dental College, Kalaburgi, Karnataka, India.; Department of
Periodontology, ESIC Dental College, Kalaburgi, Karnataka, India.
PY - 2020
SN - 0972-124X (Print)
SP - 244-252
ST - Comparative evaluation of 2% turmeric extract with nanocarrier and 1%
TI - Comparative evaluation of 2% turmeric extract with nanocarrier and 1%
VL - 24
Y2 - 5
ID - 14346
ER -
TY - JOUR
AB - Chamomile and plantain are plants recognized and used by the population
worldwide due to its anti-inflammatory, astringent and antibacterial properties.
These plants have been used in the treatment of various inflammatory processes,
including those of the oral cavity such as gingivitis and periodontitis, among
others. The scarce scientific publication about the antimicrobial effect of these
plants merging their properties motivated the realization of the present pilot
study, in order to determine the clinical and antimicrobial effect of chamomile gel
5% and plantain 2% on the subgingival microbiota in the treatment of periodontitis
through confirmatory, experimental research, with a sample of 8 patients diagnosed
with chronic periodontitis who attended the clinic of Periodontics of the FOULA in
September 2017. The sample consisted of 4 patients for the experimental group,
subjected to conventional therapy of periodontal treatment plus the application of
chamomile gel 5% and plantain 2% and 4 patients for the control group, which
received conventional therapy plus a placebo gel. The data were collected in
clinical-microbiological records, evaluating depth of the periodontal sacs,
gingival index, hemorrhagic, O'leary and counting of colony forming units in both
study groups before, during and after the treatment was applied. The data obtained
were analyzed by descriptive statistics, concluding that the gel of 5% chamomile
and 2% plantain as a coadjuvant of periodontal therapy favors the recovery of
periodontal tissues and decrease of the colony forming units of black pigmented
bacteria, constituent of the subgingival microbiota.
AN - rayyan-563562023
AU - Gutierrez, R.
AU - Salas, E.
AU - Gil, A.
IS - 17
PY - 2019
SN - 2244-8136
SP - 117-138
ST - ANTIMICROBIAL EFFECT OF CHAMOMILE GEL AND LLANTEN ON THE SUBGINGIVAL
MICROBIOTE IN THE TREATMENT OF PERIODONTITIS. PRELIMINARY STUDY
T2 - ACTA BIOCLINICA
TI - ANTIMICROBIAL EFFECT OF CHAMOMILE GEL AND LLANTEN ON THE SUBGINGIVAL
MICROBIOTE IN THE TREATMENT OF PERIODONTITIS. PRELIMINARY STUDY
VL - 9
Y2 - 1
ID - 15397
ER -
TY - JOUR
AB - Periodontitis is a common chronic and destructive disease whose pathogenetic
mechanisms remain unclear. Due to their sensitivity and global scale, proteomics
studies offer the opportunity to uncover critical host and pathogen activity
indicators and can elucidate clinically applicable biomarkers for improved
diagnosis and treatment of the disease. This review summarizes the literature of
proteomics studies on periodontitis and comprehensively discusses commonly found
candidate biomarkers. Key considerations in the design of an experimental
proteomics platform are also outlined. The applicability of protein biomarkers
across the progression of periodontitis and unexplored areas of research are
highlighted. © 2014 Informa UK, Ltd.
AN - rayyan-563560430
AU - Guzman, Y. A.
AU - Sakellari, D.
AU - Arsenakis, M.
AU - Floudas, C. A.
DO - 10.1586/14789450.2014.864953
IS - 1
KW - ABC transporter
actin related protein
adenyl cyclase associated protein 1
alpha 2 macroglobulin
alpha defensin
amylase
apolipoprotein
apolipoprotein A1
apolipoprotein B100
beta defensin
biological marker
calgranulin B
carbonate dehydratase I
carbonate dehydratase II
carbonyl reductase
carbonyl reductase 1
catalase
cystatin
fibrinogen
haptoglobin
hemoglobin
high density lipoprotein cholesterol
neutrophil defensin 1
plastin
profilin
stratifin
unclassified drug
vitamin D binding protein
down regulation
electrospray mass spectrometry
experimental design
gel electrophoresis
gingivitis
human
periodontitis
protein analysis
proteomics
review
saliva
upregulation
LA - English
PY - 2014
SN - ["1478-9450", "1744-8387"]
SP - 31-41
ST - Proteomics for the discovery of biomarkers and diagnosis of periodontitis: A
critical review
T2 - Expert Rev. Proteomics
TI - Proteomics for the discovery of biomarkers and diagnosis of periodontitis: A
critical review
VL - 11
ID - 13804
ER -
TY - JOUR
AB - The present work aims to investigate the efficacy of thermoreversible gel of
cranberry juice concentrate (CJC) as local drug delivery for the treatment of
periodontitis. CJC was initially tested for its antimicrobial activities like MIC,
MBC, antiadhesion, antibiofilm and time kill assay against the panel of organisms
(S. mutans (SM), E. faecalis (EF), A. actinomycetemcomitans (AA), P. gingivalis
(PG), T. forsythia (TF)) responsible for periapical and periodontal infections.
Antimicrobial activity of CJC showed MIC value of 50mg/ml and MBC value of 100mg/ml
with desirable antiadhesion (83-90%) and antibiofilm activity (70-85%). CJC was
evaluated for its biocompatibility using periodontal fibroblasts by cell based MTT
assay and found to be nontoxic. Influence of CJC on periodontopathogen PG derived
virulence factors (fimA and kgp) was studied using real time polymerase chain
reaction (RT-PCR) technique wherein down regulation of selected genes demonstrated
inhibitory effect against PG virulence factors. Thermoreversible gel of CJC was
formulated by cold method using poloxamer 407 as thermosensitive polymer and
carbopol 934 as mucoadhesive polymer and evaluated for its gelation temperature,
viscosity, gel strength and mucoadhesive strength. Comparison of optimized
thermoreversible gel of CJC (500mg/ml) with commercially available chlorhexidine
gluconate gel (0.2%) using agar well diffusion demonstrated equal zone of
inhibition against SM, EF, AA, PG & TF. Hence the formulated thermoreversible gel
of CJC could serve as a novel herbal alternative to currently available periodontal
treatment modalities.
AN - rayyan-563560297
AU - H R, R.
AU - Dhamecha, D.
AU - Jagwani, S.
AU - Patil, D.
AU - Hegde, S.
AU - Potdar, R.
AU - Metgud, R.
AU - Jalalpure, S.
AU - Roy, S.
AU - Jadhav, K.
AU - Tiwari, N. K.
AU - Koduru, S.
AU - Hugar, S.
AU - Dodamani, S.
DO - 10.1016/j.msec.2017.03.054
gel
bacterium
cell culture
chemistry
cranberry
cytology
fibroblast
fruit and vegetable juice
human
materials testing
metabolism
microbiology
periodontium
preclinical study
LA - English
PY - 2017
SN - 1873-0191
SP - 1506-1514
ST - Formulation of thermoreversible gel of cranberry juice concentrate:
Evaluation, biocompatibility studies and its antimicrobial activity against
periodontal pathogens
TI - Formulation of thermoreversible gel of cranberry juice concentrate:
VL - 75
ID - 13671
ER -
TY - JOUR
AB - The present work aims to investigate the efficacy of thermoreversible gel of
cranberry juice concentrate (CJC) as local drug delivery for the treatment of
periodontitis. CJC was initially tested for its antimicrobial activities like MIC,
MBC, antiadhesion, antibiofilm and time kill assay against the panel of organisms
(S. mutans (SM), E. faecalis (EF), A. actinomycetemcomitans (AA), P. gingivalis
(PG), T. forsythia (TF)) responsible for periapical and periodontal infections.
Antimicrobial activity of CJC showed MIC value of 50mg/ml and MBC value of 100mg/ml
with desirable antiadhesion (83-90%) and antibiofilm activity (70-85%). CJC was
evaluated for its biocompatibility using periodontal fibroblasts by cell based MTT
assay and found to be nontoxic. Influence of CJC on periodontopathogen PG derived
virulence factors (fimA and kgp) was studied using real time polymerase chain
reaction (RT-PCR) technique wherein down regulation of selected genes demonstrated
inhibitory effect against PG virulence factors. Thermoreversible gel of CJC was
formulated by cold method using poloxamer 407 as thermosensitive polymer and
carbopol 934 as mucoadhesive polymer and evaluated for its gelation temperature,
viscosity, gel strength and mucoadhesive strength. Comparison of optimized
thermoreversible gel of CJC (500mg/ml) with commercially available chlorhexidine
gluconate gel (0.2%) using agar well diffusion demonstrated equal zone of
inhibition against SM, EF, AA, PG & TF. Hence the formulated thermoreversible gel
of CJC could serve as a novel herbal alternative to currently available periodontal
treatment modalities.
AN - rayyan-563560833
AU - H, R. R.
AU - Dhamecha, D.
AU - Jagwani, S.
AU - Patil, D.
AU - Hegde, S.
AU - Potdar, R.
AU - Metgud, R.
AU - Jalalpure, S.
AU - Roy, S.
AU - Jadhav, K.
AU - Tiwari, N. K.
AU - Koduru, S.
AU - Hugar, S.
AU - Dodamani, S.
DO - 10.1016/j.msec.2017.03.054
J2 - Mater Sci Eng C Mater Biol Appl
KW - *Anti-Bacterial Agents/chemistry/pharmacology
Bacteria/*growth & development
Cells, Cultured
Drug Evaluation, Preclinical
Fibroblasts/cytology/*metabolism
*Fruit and Vegetable Juices
Gels
Humans
*Materials Testing
Periodontium/*microbiology
Vaccinium macrocarpon/*chemistry
LA - eng
N1 - Department of Periodontics, KLE VK Institute of Dental Sciences, KLE
University, Nehru Nagar, Belgaum 590010, Karnataka, India. Electronic address:
dr.rashree@gmail.com.; Dr. Prabhakar Kore Basic Science Research Center, KLE
University, Belgaum 590010, Karnataka, India. Electronic address:
dineshdhamecha@gmail.com.; Dr. Prabhakar Kore Basic Science Research Center, KLE
University, Belgaum 590010, Karnataka, India.; Dr. Prabhakar Kore Basic Science
Research Center, KLE University, Belgaum 590010, Karnataka, India.; ICMR-National
Institute of Traditional Medicine, (Formerly Regional Medical Research Centre),
Department of Health Research (Government of India), Belgaum 590010, Karnataka,
India.; Department of Periodontics, KLE VK Institute of Dental Sciences, KLE
University, Nehru Nagar, Belgaum 590010, Karnataka, India.; Department of
Periodontics, KLE VK Institute of Dental Sciences, KLE University, Nehru Nagar,
Belgaum 590010, Karnataka, India.; Dr. Prabhakar Kore Basic Science Research
Center, KLE University, Belgaum 590010, Karnataka, India; KLE University's College
of Pharmacy, Nehru Nagar, Belgaum 590010, Karnataka, India.; ICMR-National
Institute of Traditional Medicine, (Formerly Regional Medical Research Centre),
Department of Health Research (Government of India), Belgaum 590010, Karnataka,
India.; KLE University's College of Pharmacy, Nehru Nagar, Belgaum 590010,
Karnataka, India.; Department of Prosthodontics, A.E.C.S. Maaruti College of Dental
Sciences and Research Centre, Bannerghatta Road, Bangalore 560076, Karnataka,
India.; Department of Periodontics, D.A.P.M. R.V. Dental College, JP Nagar,
Bangalore 560078, Karnataka, India.; Department of Periodontics, KLE VK Institute
of Dental Sciences, KLE University, Nehru Nagar, Belgaum 590010, Karnataka, India.;
Dr. Prabhakar Kore Basic Science Research Center, KLE University, Belgaum 590010,
Karnataka, India.
PY - 2017
SP - 1506-1514
T2 - Materials science & engineering. C, Materials for biological applications
VL - 75
Y2 - 6 y3 - 1
ID - 14207
ER -
TY - JOUR
AB - Periodontitis (PD) is a microbial disease of tooth supporting tissues that
results in progressive destruction of surrounding soft and hard tissues with
eventual tooth mobility and exfoliation. Perioceutics, which includes the delivery
of therapeutic agents via systemic and local means as an adjunct to mechanical
therapy has revolutionized the arena of periodontal therapy. Selection of a right
antimicrobial agent with appropriate route of drug administration is the key to
successful periodontal therapy. Irrigating systems, fibers, gels, strips, films,
microparticles, nanoparticles and low dose antimicrobial agents are some of the
local drug delivery systems (LDDS) available in the field, which aims to deliver
antimicrobial agents to sub-gingival diseased sites with minimal or no side-effects
on other body sites. The present review aim to summarize the current state-of-the-
art technology on LDDS in periodontal therapy ensuring the the practitioners are
able to choose LDD agents which are custom made for a specific clinical condition.
AN - rayyan-563560180
AU - H.R, R.
AU - Dhamecha, D.
AU - Jagwani, S.
AU - Rao, M.
AU - Jadhav, K.
AU - Shaikh, S.
AU - Puzhankara, L.
AU - Jalalpure, S.
DO - 10.1016/j.jconrel.2019.06.038
nanoparticle
first pass effect
gel
nonhuman
periodontal pocket
periodontist
periodontitis
priority journal
review
surface property
tooth
LA - English
PY - 2019
SN - ["1873-4995", "0168-3659"]
SP - 393-409
ST - Local drug delivery systems in the management of periodontitis: A scientific
review
TI - Local drug delivery systems in the management of periodontitis: A scientific
review
VL - 307
ID - 13554
ER -
TY - JOUR
AB - Background. The authors investigated mouthrinses' antimicrobial effectiveness
against predominant oral-bacteria, as determined by the minimum inhibitory
concentration they evaluated an (MIC). Specifically, herbal mouthrinse, an
essential oil rinse and a 0.12 percent chlorhexidine gluconate rinse. Methods. The
authors assessed the inhibitory effects of the three test agents against 40 oral
bacteria at concentrations of 1, 2, 4, 8, 16, 32, 64, 128, 256 and 512 micrograms
per millliter. They inoculated plates containing basal medium and the test agents
with suspensions of the test species and incubated them anaerobically at 35 degrees
C. The authors interpreted the MIC as the lowest concentration of the agent that
completely inhibited the growth of the test species. Results. The herbal mouthrinse
inhibited the growth of most of the 40 test species. Compared with the essential
oil mouthrinse, the herbal mouthrinse exhibited significantly lower MICs for
Actinomyces species, periodontal pathogens Eubacterium nodatum, Tannerella
forsythia and Prevotella species, as well as the cariogenic pathogen Streptococcus
mutans. The chlorhexidine gluconate rinse had the lowest MICs compared with the
essential oil rinse and the herbal rinse for an test species examined. Conclusions.
Although less potent than the chlorhexidine gluconate rinse, the herbal rinse was
more effective than-the essential oil rinse in inhibiting the growth of oral
bacteria in vitro. Clinical Implications. The data suggest that the herbal
mouthrinse may provide oral health benefits by inhibiting the growth of periodontal
and cariogenic: pathogens. In vivo clinical testing is essential to confirm in
vitro results.
AN - rayyan-563562437
AU - Haffajee, A. D.
AU - Yaskell, T.
AU - Socransky, S. S.
DO - 10.14219/jada.archive.2008.0222
IS - 5
PY - 2008
SN - ["0002-8177", "1943-4723"]
SP - 606-611
ST - Antimicrobial effectiveness of an herbal mouthrinse compared with an
essential oil and a chlorhexidine mouthrinse
T2 - JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
TI - Antimicrobial effectiveness of an herbal mouthrinse compared with an
essential oil and a chlorhexidine mouthrinse
VL - 139
Y2 - 5
ID - 15811
ER -
TY - JOUR
AB - This study was performed to assess the effect of scaling and root planing
clinically and microbiologically during one year. Nine patients with moderate to
severe periodontitis were studied. After the process of plaque control, the
selected single rooted teeth with 5mm probing depth were debrided mechanically
under non-local anesthesia four times biweekly. Observing the results of the
treated teeth until three months, the experimental teeth were divided into two
groups. The standard of division was whether they showed good response to the
mechanical debridement or not. Observation was continued until one year after the
debridement according to the following criteria: 1. The sites which showed good
responses at three months were continued to be observed biweekly. 2. The sites
which showed no improvement at three months were applied the gel of minocycline
(Periocline) four times biweekly. 3. The untreated sites used as control until
three months received mechanical debridement four times biweekly. The following
results were obtained: The sites that showed good responses to the mechanical
debridement at three months were maintained in good condition continuously during
one year. The topical application of Periocline was effective in reducing the
inflammation and probing depth clinically and microbiologically until three months.
AN - rayyan-563561139
AU - Hagiwara, S.
AU - Iida, M.
AU - Ishikawa, I.
DO - 10.5357/koubyou.60.301
IS - 2
KW - minocycline
adult
article
debridement
evaluation study
female
follow up
human
male
microbiology
middle aged
periodontitis
LA - Japanese
PY - 1993
SN - 0300-9149
SP - 301-312
ST - Clinical and microbiological study concerning effects of scaling and root
planing. 2. The effects of mechanical debridement until one year and of minocycline
application topically
T2 - Kokubyo Gakkai Zasshi
TI - Clinical and microbiological study concerning effects of scaling and root
planing. 2. The effects of mechanical debridement until one year and of minocycline
application topically
VL - 60
ID - 14513
ER -
TY - JOUR
AB - Biomaterials applications have rapidly expanded into different fields of
sciences. One of the important fields of using biomaterials is dentistry, which can
facilitate implantation, surgery, and treatment of oral diseases such as peri-
implantitis, periodontitis, and other dental problems. Drug delivery systems based
on biocompatible materials play a vital role in the release of drugs into aim
tissues of the oral cavity with minimum side effects. Therefore, scientists have
studied various delivery systems to improve the efficacy and acceptability of
therapeutic approaches in dental problems and oral diseases. Also, biomaterials
could be utilized as carriers in biocompatible drug delivery systems. For instance,
natural polymeric substances, such as gelatin, chitosan, calcium phosphate,
alginate, and xanthan gum are used to prepare different forms of delivery systems.
In addition, some alloys are conducted in drug complexes for the better in
transportation. Delivery systems based on biomaterials are provided with different
strategies, although individual biomaterial has advantages and disadvantages which
have a significant influence on transportation of complex such as solubility in
physiological environments or distribution in tissues. Biomaterials have
antibacterial and anti-inflammatory effects and prolonged time contact and even
enhance antibiotic activities in oral infections. Moreover, these biomaterials are
commonly prepared in some forms such as particulate complex, fibers, microspheres,
gels, hydrogels, and injectable systems. In this review, we examined the
application of biocompatible materials in drug delivery systems of oral and dental
diseases or problems.
AN - rayyan-563560055
AU - Hakim, L. K.
AU - Yazdanian, M.
AU - Alam, M.
AU - Abbasi, K.
AU - Tebyaniyan, H.
AU - Tahmasebi, E.
AU - Khayatan, D.
AU - Seifalian, A.
AU - Ranjbar, R.
AU - Yazdanian, A.
DO - 10.1155/2021/9011226
KW - fiber
alginic acid
antibiotic agent
antiinfective agent
biomaterial
calcium phosphate
chitosan
drug carrier
gel
gelatin
gold nanoparticle
hyaluronic acid
hydrogel
metal nanoparticle
microsphere
silver nanoparticle
stabilizing agent
biocompatibility
bone development
complex formation
human
injection
mouth cavity
mouth disease
mouth infection
nonhuman
review
tooth disease
LA - English
PY - 2021
SN - ["1741-4288", "1741-427X"]
ST - Biocompatible and Biomaterials Application in Drug Delivery System in Oral
Cavity
T2 - Evid.-Based Complement. Altern. Med.
TI - Biocompatible and Biomaterials Application in Drug Delivery System in Oral
Cavity
VL - 2021
ID - 13429
ER -
TY - JOUR
AB - OBJECTIVE: The aim was to evaluate the effect of a chlorhexidine-containing
brush-on gel when used as supplement to oral hygiene instructions and mechanical
debridement, on peri-implant mucositis in adults. MATERIALS AND METHODS: The study
group consisted of 38 adults (48-87 years.) with peri-implant mucositis that were
consecutively enrolled in three private clinics after informed consent. The study
employed a double-blind controlled design with two parallel arms. After baseline
registrations, oral hygiene reinforcement and mechanical debridement, the patients
were randomly allocated to either a test group with once daily tooth brushing with
an oral care brush-on gel containing 0.2% chlorhexidine digluconate (Cervitec Gel)
or a control gel group. The duration of the intervention was 12 weeks. The primary
outcome was bleeding on probing (BOP) and secondary endpoints were local plaque
score (LPS) and pocket probing depth (PPD). RESULTS: The groups were balanced at
baseline. The daily use of the chlorhexidine-containing gel resulted in reduced BOP
after 4 and 12 weeks compared with the control group (P < 0.05). The PPD was
significantly reduced (P < 0.05) after 12 weeks compared to baseline in the test
group, but not in the control group. No side effects or adverse events were
reported. CONCLUSION: The present findings indicated moderate but significant
improvements of clinical parameters when mechanical debridement was combined with a
self-applied oral care brush-on gel for the management of peri-implant mucositis.
AN - rayyan-563560299
AU - Hallström, H.
AU - Lindgren, S.
AU - Twetman, S.
DO - 10.1111/idh.12184
IS - 2
KW - chlorhexidine
thymol
aged
comparative study
controlled study
debridement
drug combination
female
gel
human
male
middle aged
mouth hygiene
periodontal index
stomatitis
tooth brushing
tooth implant
very elderly
LA - English
PY - 2017
SN - 1601-5037
SP - 149-153
ST - Effect of a chlorhexidine-containing brush-on gel on peri-implant mucositis
T2 - Int J Dent Hyg
TI - Effect of a chlorhexidine-containing brush-on gel on peri-implant mucositis
VL - 15
ID - 13673
ER -
TY - JOUR
AB - The aim of this study was to develop an ibuprofen microemulsion (IBU–ME)
incorporated into in situ gels (microgels) for local delivery into periodontal
pockets. The IBU–ME was prepared at a concentration of 1% w/v IBU. Various
concentrations of the thermosensitive Pluronic® F127 (P127) solution and a series
of combinations of the P127 solution and IBU–ME at a 1:1 ratio were initially
developed and tested to determine their sol–gel transition temperatures (Tsol→gel).
Based on these studies, a constant concentration of P127 (11.1% w/v) and variable
concentrations of IBU–ME were used to prepare the microgels. The mechanical
properties (Tsol→gel, gelling time (Tgel), viscosity, and viscoelastic properties)
of the microgels were evaluated. The release of IBU from the microgels was
determined in vitro. Rheological stability studies were performed to investigate
the mechanical properties of the microgels after one month. The transition behavior
studies demonstrated that the microgels are thermosensitive systems with
pseudoplastic flow and their viscoelastic properties indicated that the elastic
property was greater than the viscous property (G′ > G″). The results showed that
the mechanical properties of the microgels depend on the concentration of IBU–ME.
In addition, rheological stability studies demonstrated that Tgel and Tsol→gel are
increased after one month, whereas the viscosity and viscoelastic properties are
decreased after one month. Owing to the rigid structure of the microgels, the
release of IBU from the microgels followed a controlled-release pattern.
AN - rayyan-563560173
AU - Hamed, R.
AU - Al-Adhami, Y.
AU - Abu-Huwaij, R.
DO - 10.1016/j.ijpharm.2019.118684
KW - ibuprofen
ketoprofen
metronidazole
poloxamer
article
cell viability
cytotoxicity
gel
in vitro study
MC3T3-E1 cell line
microemulsion
mouth temperature
nanoemulsion
periodontal pocket
priority journal
salivation
solubility
swelling
transition temperature
viscoelasticity
viscosity
LA - English
PY - 2019
SN - ["1873-3476", "0378-5173"]
ST - Concentration of a microemulsion influences the mechanical properties of
ibuprofen in situ microgels
T2 - Int. J. Pharm.
TI - Concentration of a microemulsion influences the mechanical properties of
ibuprofen in situ microgels
VL - 570
ID - 13547
ER -
TY - JOUR
AN - rayyan-563561188
AU - Hanamura, Y.
AU - Toki, T.
AU - Watanabe, K.
AU - Murata, F.
AU - Miyata, Y.
IS - 5
KW - benzethonium chloride
benzocaine
benzyl alcohol derivative
benzyl derivative
BZC jelly
quaternary ammonium derivative
adolescent
adult
aged
animal
article
child
dental anesthesia
drug combination
drug effect
female
gel
guinea pig
human
male
middle aged
periodontium
rat
LA - Japanese
PY - 1983
SN - 0011-8702
SP - 1027-1033
ST - Use of topical anesthetic BZC jelly in the periodontal region--experimental
and clinical studies
T2 - Shikai Tenbo
TI - Use of topical anesthetic BZC jelly in the periodontal region--experimental
and clinical studies
VL - 61
ID - 14562
ER -
TY - JOUR
AB - Exploration of natural substance may support and enhance bone remodeling
during orthodontic tooth movement (OTM). One of potential candidate that may
enhance bone remodeling during OTM is a propolis extract. The main component that
consisted in propolis extract are flavonoids, saponin and caffeic acid phenethyl
ester (CAPE). Propolis well-known as beneficial food, supplement and herbal
medicine. OTM that prescribe mechanical stress in the tooth and periodontal tissue
may induce local inflammation. The aim of the study is to investigate the
expression of Transforming Growth Factor-β (TGF-β) in the tension side of OTM after
propolis local administration. This study was randomized post-test only control
group design. Twentyeight male Cavia cobayas were divided into 4 groups namely:
without OTM and propolis administration (K-), rubber separator as OTM (K+), OTM and
3% propolis gel extract (P1) and OTM and 5% propolis gel extract. TGF-β expression
in the osteoblast of alveolar bone in the tension side during OTM was evaluated by
means of immunohistochemical staining then, analysis of variance (ANOVA) with post
hoc test was performed with p<0.05 considered as statistically significant. TGF-β
expression was enhanced in the tension side of alveolar bone during OTM after local
administration of propolis gel extract with significantly different between groups
(p<0.05). In conclusion, 5% of propolis gel extract is the most effective
concentration that has ability to increase TGF b expression in tension side of
alveolar bone during orthodontic tooth movement.
AN - rayyan-563560007
AU - Handayani, B.
AU - Brahmanta, A.
AU - Prameswari, N.
AU - Syahdinda, M. R.
IS - 1
KW - gel
propolis extract
animal experiment
animal tissue
article
Cavia porcellus
controlled study
male
nonhuman
orthodontic tooth movement
protein expression
LA - English
PY - 2021
SN - ["0976-1772", "0972-5075"]
SP - 1859-1862
ST - Transforming Growth Factor-β Expression in the Tension Side of Orthodontic
Tooth Movement After Local Administration of Propolis Gel Extract
TI - Transforming Growth Factor-β Expression in the Tension Side of Orthodontic
Tooth Movement After Local Administration of Propolis Gel Extract
VL - 21
ID - 13381
ER -
TY - JOUR
AB - BACKGROUND: It is well recognized that periodontal diseases are bacterial in
nature. An essential component of therapy is to eliminate or control these
pathogens. This has been traditionally accomplished through mechanical means
(scaling and root planing [SRP]), which is time-consuming, difficult, and sometimes
ineffective. Over the past 20 years, locally delivered, anti-infective
pharmacological agents, most recently employing sustained-release vehicles, have
been introduced to achieve this goal. RATIONALE: This systematic review evaluates
literature-based evidence in an effort to determine the efficacy of currently
available anti-infective agents, with and without concurrent SRP, in controlling
chronic periodontitis. FOCUSED QUESTION: In patients with chronic periodontitis,
what is the effect of local controlled-release anti-infective drug therapy with or
without SRP compared to SRP alone on changes in clinical, patient-centered, and
adverse outcomes? SEARCH PROTOCOL: MEDLINE, the Cochrane Central Trials Register,
and Web of Science were searched. Hand searches were performed of the Journal of
Clinical Periodontology, Journal of Periodontology, and Journal of Periodontal
Research. Searches were performed for articles published through April 2002. In
addition, investigators contacted editors of the above-mentioned journals and
companies sponsoring research on these agents for related unpublished data and
studies in progress. SELECTION CRITERIA: INCLUSION CRITERIA: Studies included
randomized controlled clinical trials (RCT), and case-controlled and cohort studies
at least 3 months long. Therapeutic interventions had to include 1) SRP alone; 2)
local anti-infective drug therapy and SRP; or 3) local anti-infective drug therapy
alone. Included studies had to report patient-based mean values and measures of
variation for probing depth (PD) and/or clinical attachment levels (CAL) for both
test and control groups. EXCLUSION CRITERIA: Studies were excluded if they: 1)
included data from a previously published article; 2) included daily rinsing with
chlorhexidine (CHX); or 3) had unclear descriptions of randomization procedures,
examiner masking, or concomitant therapies. DATA COLLECTION AND ANALYSIS: For the
meta-analysis, PD and CAL were expressed as summary mean effects with 95%
confidence intervals (CI) for the effect, and analyzed using a standardized
difference between SRP alone and experimental agent groups. The results were
assessed with both fixed-effects and random-effects models. Studies were ranked
according to the York system. MAIN RESULTS: 1. Thirty-two studies were included (28
RCT, 2 cohort, and 2 case-control), incorporating a total patient population of
3,705 subjects. 2. Essentially all studies reported substantial reductions in
gingival inflammation and bleeding indices, which were similar in both control and
experimental groups. 3. A meta-analysis completed on 19 studies that included SRP
and local sustained-release agents compared with SRP alone indicated significant
adjunctive PD reduction or CAL gain for minocycline (MINO) gel, microencapsulated
MINO, CHX chip and doxycycline (DOXY) gel during SRP compared to SRP alone. 4. Use
of antimicrobial irrigants or anti-infective sustained-release systems as an
adjunct to SRP does not result in significant patient-centered adverse events.
REVIEWERS' CONCLUSIONS: 1. In some populations, anti-infective agents in a
sustained-release vehicle alone can reduce PD and bleeding on probing (BOP)
equivalent to that achieved by SRP alone. 2. No evidence was found for an
adjunctive effect on reduction of PD and BOP of therapist-delivered CHX irrigation
during SRP compared to SRP alone. 3. Additional RCTs are needed which evaluate the
effectiveness of these therapies in all forms of periodontitis. 4. The study
protocol for future RCTs should include appropriate statistical analyses and
complete data sets to facilitate future evidence-based reviews. 5. Alternative
surrogate parameters to PD and CAL need to be identified and validated such as
microbial, inflammatory, or t ssue-destructive markers that could be used in
conjunction with clinical parameters to help determine the patient's response to
emerging technologies that target the infectious and/or inflammatory aspects of
periodontitis. 6. Future Phase IV clinical trials should be designed that evaluate
local anti-infective therapies in conjunction with SRP in a manner consistent with
current standards of care and evaluate cost-effectiveness. 7. The use of local
anti-infective agents in at-risk patient populations and for the treatment of at-
risk disease sites needs to be validated in randomized controlled clinical trials.
8. Several local anti-infective agents combined with SRP appear to provide
additional benefits in PD reduction and CAL gain compared to SRP alone. The
decision to use local anti-infective adjunctive therapy remains a matter of
individual clinical judgment, the phase of treatment, and the patient's status and
preferences.
AN - rayyan-563560875
AU - Hanes, P. J.
AU - Purvis, J. P.
DO - 10.1902/annals.2003.8.1.79
IS - 1
KW - alkaloid
antiinfective agent
benzophenanthridine derivative
chlorhexidine
doxycycline
isoquinoline derivative
metronidazole
minocycline
sanguinarine
tetracycline
clinical trial
human
meta analysis
periodontitis
review
LA - English
PY - 2003
SN - 1553-0841
SP - 79-98
ST - Local anti-infective therapy: pharmacological agents. A systematic review
T2 - Ann. Periodontol.
TI - Local anti-infective therapy: pharmacological agents. A systematic review
VL - 8
ID - 14249
ER -
TY - JOUR
AB - The aim of this study was to investigate tooth whitening efficacy and oral
side effects during bleaching with Whitestrips® (WS) (6% hydrogen peroxide H2O2
gel) and Vivadent Vivastyle® (VS) (10% carbamide peroxide gel). Forty-seven
subjects were included in this single blind, randomized, parallel group study.
Application of WS was performed twice a day for 30 min. Trays filled with VS were
worn for 60 min once a day. Tooth color was evaluated by measuring L*a*b* values
before the study and after completion of the bleaching. Treatment tolerability was
monitored throughout bleaching with an 8-week follow-up after completion of
therapy. After 2 weeks both treatment groups demonstrated significant improvements
in tooth color compared to baseline. A shift toward less yellow (-Δb) and brighter
(+ΔL) tooth color was observed. Δb amounted to -1.69 ± 0.38 for WS and -1.20 ± 0.34
for VS (mean value ± SE). ΔL was +1.55 ± 0.41 for WS and +1.20 ± 0.37 for VS. There
was no significant difference between the two systems. No significant differences
between the two bleaching systems were recorded for clinically observed signs or
reported symptoms. Gingival irritation was observed in 13%, reported tooth
hypersensitivities in 22% and reported gum irritation in 20% of the total study
population. At an 8-week follow-up visit no adverse effects were observed. Both WS
and VS demonstrated significant and comparable levels of tooth color improvement
after 2 weeks. Each treatment caused similar levels of transient oral side effects.
© Springer-Verlag 2007.
AN - rayyan-563560730
AU - Hannig, C.
AU - Lindner, D.
AU - Attin, T.
DO - 10.1007/s00784-007-0128-x
IS - 4
hydrogen peroxide
oxidizing agent
peroxide
urea
carbamide peroxide
adolescent
adult
article
clinical trial
color
comparative study
controlled study
dental procedure
drug combination
drug effect
female
follow up
gel
gingiva
gingivitis
histology
human
devices
male
medical photography
methodology
middle aged
time
tooth
treatment outcome
LA - English
PY - 2007
SN - ["1432-6981", "1436-3771"]
SP - 321-329
ST - Efficacy and tolerability of two home bleaching systems having different
peroxide delivery
TI - Efficacy and tolerability of two home bleaching systems having different
peroxide delivery
VL - 11
ID - 14104
ER -
TY - JOUR
AN - rayyan-563561211
AU - Hansen, F.
AU - Gjermo, P.
AU - Eriksen, H. M.
IS - 3
KW - cariden
chlorhexidine
placebo
toothpaste
unclassified drug
gingiva
gingivitis
human
mouth hygiene
normal human
theoretical study
tooth plaque
LA - English
PY - 1975
SP - 153-159
ST - The effect of a chlorhexidine containing gel on oral cleanliness and gingival
health in young adults
T2 - J.CLIN.PERIODONT.
TI - The effect of a chlorhexidine containing gel on oral cleanliness and gingival
health in young adults
VL - 2
ID - 14585
ER -
TY - COMP
AB - OBJECTIVE: In vitro testing of antimicrobial agents is an important tool in
the testing hierarchy, and may provide interesting insights into their potential
clinical efficacy. Agents with demonstrable in vitro antimicrobial activity may be
effective against the same microorganisms in vivo, whereas agents without
demonstrable in vitro antimicrobial activity are unlikely to exhibit in vivo
antimicrobial activity. In addition, these methods may also be useful in screening
antimicrobial agents in product formulations because such agents with both in vitro
and in vivo activity may have reduced antimicrobial effects when formulated into a
dentifrice. Accordingly, this study examined the in vitro and ex vivo antimicrobial
activity of three commercial dentifrices: one formulated with 0.243% sodium
fluoride (Crest Cavity Protection Toothpaste-Regular); one with 0.454% stannous
fluoride, sodium hexametaphosphate, and zinc lactate (Crest Pro-Health), and one
with 0.3% triclosan, 2.0% PVM/MA copolymer, and 0.243% sodium fluoride (Colgate
Total). METHODS: The minimum inhibitory concentration (MIC) of each dentifrice was
determined for resident oral bacterial species, including bacteria that are
associated with dental caries; periodontitis, and oral halitosis. Evaluations were
performed on individual laboratory strains, and on oral bacteria from supragingival
plaque samples obtained from 10 adults and from oral rinse samples obtained from 18
adults. RESULTS: The lowest MICs against the oral strains and human samples, i.e.,
greatest antimicrobial activity, were seen for the triclosan/ copolymer dentifrice.
There was, in general, a four-fold difference in MICs between the
triclosan/copolymer dentifrice and the stannous fluoride/sodium
hexametaphosphate/zinc lactate dentifrice. The triclosan/copolymer dentifrice
significantly inhibited periodontal pathogens, such as Aggregatibacter
actinomycetemcomitans, Eikenella corrodens, and Fusobacterium nucleatum. In ex vivo
tests measuring antimicrobial effects, the triclosan/copolymer dentifrice
substantially inhibited bacterial growth after 30-, 60-, and 120-second exposures
compared to the sodium fluoride or stannous fluoride/sodium hexametaphosphate/zinc
lactate dentifrices. Similarly, in ex vivo tests measuring antimicrobial effects on
supragingival plaque biofilms, the triclosan/copolymer dentifrice substantially
inhibited bacterial growth compared to the other test dentifrices. CONCLUSION:
Different in vitro and ex vivo analyses show that the triclosan/copolymer
dentifrice has significant antimicrobial activity on oral bacteria, including
species causing dental caries, periodontitis, and oral halitosis, and it provides
superior efficacy compared to the stannous fluoride/sodium hexametaphosphate/zinc
lactate dentifrice.
AN - rayyan-563561370
AU - Haraszthy, V. I.
AU - Zambon, J. J.
AU - Sreenivasan, P. K.
CY - United States
ET - 4
J2 - J Clin Dent
KW - Adult
Anti-Infective Agents, Local/chemistry/*pharmacology
Bacteria/*drug effects
Cariostatic Agents/pharmacology
Dentifrices/chemistry/*pharmacology
Drug Combinations
Humans
Maleates
Mouth/*microbiology
Phosphates/chemistry/pharmacology
Polyethylenes
Silicic Acid/chemistry/pharmacology
Sodium Fluoride
Tin Fluorides/chemistry/pharmacology
Toothpastes/chemistry/pharmacology
Triclosan
Zinc Compounds
LA - eng
N1 - School of Dental Medicine, University at Buffalo Buffalo, NY, USA.
PY - 2010
SN - 0895-8831 (Print)
SP - 96-100
ST - Evaluation of the antimicrobial activity of dentifrices on human oral
bacteria
TI - Evaluation of the antimicrobial activity of dentifrices on human oral
bacteria
VL - 21
ID - 14744
ER -
TY - JOUR
AB - Objective: In vitro testing of antimicrobial agents is an important tool in
the testing hierarchy, and may provide interesting insights into their potential
clinical efficacy. Agents with demonstrable In vitro antimicrobial activity may be
effective against the same microorganisms in vivo, whereas agents without
demonstrable in vitro antimicrobial activity are unlikely to exhibit in vivo
antimicrobial activity. In addition, these methods may also be useful in screening
antimicrobial agents in product formulations because such agents with both in vitro
and in vivo activity may have reduced antimicrobial effects when formulated into a
dentifrice. Accordingly, this study examined the In vitro and ex vivo antimicrobial
activity of three commercial dentifrices: one formulated with 0.243% sodium
fluoride (Crest®Cavity Protection Toothpaste-Regular); one with 0.454% stannous
fluoride, sodium hexametaphosphate, and zinc lactate (Crest®Pro-Health® and one
with 0.3% triclosan, 2.0% PVM/MA copolymer, and 0.243% sodium fluoride
(Colgate®Total® Methods: The minimum inhibitory concentration (MIC) of each
dentifrice was determined for resident oral bacterial species, including bacteria
that are associated with dental caries, periodontitis, and oral halitosis.
Evaluations were performed on individual laboratory strains, and on oral bacteria
from supragingival plaque samples obtained from 10 adults and from oral rinse
samples obtained from 18 adults. Results: The lowest MICs against the oral strains
and human samples, i.e., greatest antimicrobial activity, were seen for the
triclosan/ copolymer dentifrice. There was, in general, a four-fold difference in
MICs between the triclosan/copolymer dentifrice and the stannous fluoride/sodium
hexametaphosphate/zinc lactate dentifrice. The triclosan/copolymer dentifrice
significantly inhibited periodontal pathogens, such as Aggregatibacter
actinomycetemcomitans, Eikenella corrodens, and Fusobacterium nucleatum. In ex vivo
tests measuring antimicrobial effects, the triclosan/copolymer dentifrice
substantially inhibited bacterial growth after 30-, 60-, and 120second exposures
compared to the sodium fluoride or stannous fluoride/sodium hexametaphosphate/zinc
lactate dentifrices. Similarly, in ex vivo tests measuring antimicrobial effects on
supragingival plaque biofilms, the triclosan/copolymer dentifrice substantially
inhibited bacterial growth compared to the other test dentifrices. Conclusion:
Different in vitro and ex vivo analyses show that the triclosan/copolymer
dentifrice has significant antimicrobial activity on oral bacteria, including
species causing dental caries, periodontitis, and oral halitosis, and it provides
superior efficacy compared to the stannous fluoride/sodium hexametaphosphate/zinc
lactate dentifrice.
AN - rayyan-563560618
AU - Haraszthy, V. I.
AU - Zambon, J.
AU - Sreenivasan, P. K.
IS - 4
Crest Pro Health Dentifrice
sodium fluoride
phosphate
silicic acid
tin fluoride
toothpaste
triclosan
zinc derivative
adult
article
bacterial count
bacterium
chemistry
comparative study
drug combination
drug effect
evaluation study
human
microbiology
mouth
LA - English
PY - 2010
SN - 0895-8831
SP - 96-100
ST - Evaluation of the antimicrobial activity of dentifrices on human oral
bacteria
T2 - J. Clin. Dent.
TI - Evaluation of the antimicrobial activity of dentifrices on human oral
bacteria
VL - 21
ID - 13992
ER -
TY - JOUR
AB - Objective: This study was undertaken to assess the effect of enamel
deproteinization with 5.25% sodium hypochlorite (NaOCl) before phosphoric acid
(H3PO4) etching on the shear bond strength of Adper ™ Single Bond 2 adhesive and
Filtek™ Z- 350 XT composite resin . Study design: Forty human sound permanent
molars which were extracted for periodontal reasons were used in the experimental
protocol as under: Group-A (20 teeth):- A 5X4 mm window of the enamel surface was
etched with 37% H3PO4 gel for 15 seconds, washed with distilled water and air
dried. A single coat of Adper™ Single Bond 2 adhesive was applied and photo
polymerized for 20 seconds and Filtek ™ Z- 350 XT composite resin block of length
5mm, width 4mm and height 5mm respectively was built and photo polymerized in
increments for 20 seconds each. Group-B (20 teeth):- Similarly the enamel surface
was treated with 5.25% NaOCl for 60 seconds, washed with distilled water and then
etched with 37% H3PO4 gel for 15 seconds, washed with distilled water and air
dried. A single coat of Adper™ Single Bond 2 adhesive was applied and photo
polymerized for 20 seconds and Filtek™ Z- 350 XT composite resin block of length
5mm, width 4mm and height 5mm respectively was built and photo polymerized in
increments for 20 seconds each. The shear bond strength of all the samples were
measured (in MPa) on Instron Mechanical Testing Machine. Results: The mean shear
bond strength value for Group-A was 13.51 ± 5.726 MPa and for Group-B being 15.06 ±
6.220 MPa. No statistically significant difference in the shear bond strengths was
observed between the two groups. Conclusions: No significant effect of sodium
hypochlorite enamel deproteinization on the shear bond strength of Adper ™ Single
Bond 2 adhesive and Filtek™ Z- 350 XT composite resin before acid etching was
observed in this study.
AN - rayyan-563560577
AU - Harleen, N.
AU - Ramakrishna, Y.
AU - Munshi, A. K.
DO - 10.17796/jcpd.36.1.l345875912750624
IS - 1
KW - resin cement
filtek Z350
hypochlorite sodium
resin
tooth cement
article
dental acid etching
dental bonding
dental procedure
drug effect
enamel
human
shear strength
LA - English
PY - 2011
SN - 1053-4628
SP - 19-24
ST - Enamel deproteinization before acid etching and its effect on the shear bond
strength - An in vitro study
T2 - J. Clin. Pediatr. Dent.
TI - Enamel deproteinization before acid etching and its effect on the shear bond
strength - An in vitro study
VL - 36
ID - 13951
ER -
TY - JOUR
AB - The salivary and serum concentrations of immunoglobulins G, M and A (IgG, IgM
and IgA), and the salivary concentrations of albumin were measured by ELISA in 30
cats with chronic gingivostomatitis and 32 healthy cats. The cats with chronic
gingvostomatitis had significantly higher salivary concentrations of IgG, IgM and
albumin, and higer serum concentrations of IgG, IgM and IgA, but significantly
lower salivary concentrations of IgA than the healthy cats. The cats with chronic
gingivostomatitis were treated with either methylprednisolone, sodium
aurothiomalate, metronidazole and spiramycin, or oral hygiene products. After three
months of treatment, the cats receiving methylprednisolone had a significant
reduction in serum IgG levels compared to the cats treated with sodium
aurothiomalate or metronidazole and spiramycin, but after six months of treatment
there were no significant differences between the groups. Before the treatments,
the levels of oral inflammation were not correlated significantly with any of the
serum or salivary immunoglobulin levels. However, the changes in oral inflammation
were correlated significantly with the changes in the salivary IgM concentration
after three and six months of treatment, and with the change in the salivary IgA
concentration after six months of treatment.
AN - rayyan-563560889
AU - Harley, R.
AU - Gruffydd-Jones, T. J.
AU - Day, M. J.
DO - 10.1136/vr.152.5.125
IS - 5
KW - albumin
aurothiomalate
cet dentrifice paste
chx guard la oral gel
chx oral cleansing solution
immunoglobulin
immunoglobulin A
immunoglobulin G
immunoglobulin M
methylprednisolone
metronidazole
spiramycin
stomorgyl
article
cat disease
chronic disease
controlled study
drug effect
Feline immunodeficiency virus
Feline leukemia virus
gingivitis
immunoglobulin blood level
mouth hygiene
mouth inflammation
nonhuman
pathogenesis
saliva level
stomatitis
treatment outcome
medrone
myocrisin
LA - English
PY - 2003
SN - 0042-4900
SP - 125-129
ST - Salivary and serum immunoglobulin levels in cats with chronic
gingivostomatitis
T2 - Vet. Rec.
TI - Salivary and serum immunoglobulin levels in cats with chronic
gingivostomatitis
VL - 152
ID - 14263
ER -
TY - JOUR
AB - Background and Objectives: It is established that both pulsed Nd:YAG (1,064
nm) and continuous diode (810 nm) dental lasers kill pathogenic bacteria (laser
antisepsis), but a quantitative method for determining clinical dosimetry does not
exist. The purpose of this study was to develop a method to quantify the efficacy
of ablation of Porphyromonas gingivalis (Pg) in vitro for two different lasers.
Study Design/Materials and Methods: The ablation thresholds for the two lasers were
compared in the following manner. The energy density was measured as a function of
distance from the output of the fiber-optic delivery system. Pg cultures were grown
on blood agar plates under standard anaerobic conditions. Blood agar provides an
approximation of gingival tissue for the wavelengths tested in having hemoglobin as
a primary absorber. Single pulses of laser energy were delivered to Pg colonies and
the energy density was increased until the appearance of a small plume was observed
coincident with a laser pulse. The energy density at this point defines the
ablation threshold. Ablation thresholds to a single pulse were determined for both
Pg and for blood agar alone. Results: The large difference in ablation thresholds
between the pigmented pathogen and the host matrix for pulsed-Nd:YAG represented a
significant therapeutic ratio and Pg was ablated without visible effect on the
blood agar. Near threshold the 810-nm diode laser destroyed both the pathogen and
the gel. Conclusions: Clinically, the pulsed Nd:YAG may selectively destroy
pigmented pathogens leaving the surrounding tissue intact. The 810-nm diode laser
may not demonstrate this selectivity due to its greater absorption by hemoglobin
and/or longer pulse duration. © 2004 Wiley-Liss, Inc.
AN - rayyan-563560854
AU - Harris, D. M.
AU - Yessik, M.
DO - 10.1002/lsm.20086
IS - 3
KW - agar
antibiotic agent
hemoglobin
allergy
antibiotic therapy
antisepsis
article
bacterial count
controlled study
dental laser
diode laser
dosimetry
energy
fiber optics
human
in vitro study
laser
neodymium laser
nonhuman
periodontitis
pigmentation
priority journal
side effect
DioLase ST Diode Dental Laser System
InPulse Nd:YAG Dental Laser
LA - English
PY - 2004
SN - 0196-8092
SP - 206-213
ST - Therapeutic ratio quantifies laser antisepsis: Ablation of Porphyromonas
gingivalis with dental lasers
TI - Therapeutic ratio quantifies laser antisepsis: Ablation of Porphyromonas
gingivalis with dental lasers
VL - 35
ID - 14228
ER -
TY - JOUR
AB - The gold standard therapy for treating the periodontal infections is the
removal of bacterial plaque and deposits of calculus from tooth surfaces by scaling
and root planning. In order to eliminate these bacterial reservoirs, beside
conventional treatment, chemo therapeutic agents are commonly prescribed by
periodontologists. To avoid the systemic side effects and development of
antibiotics resistance, local drug delivery methods has gained the attention of
dentists to treat periodontal infections, along with scaling and root planning. The
aim of this study was to evaluate the effectiveness of local drug delivery system
in combination with scaling and root planning, by using 1% metronidazole gel and
mouthwash. The patients were divided into 3 groups. Group I: conventional treatment
group. Group II: patients received treatment with gel. Group III: patients received
treatment with mouthwash. All groups received treatment for 30 days. Clinical
parameters and salivary concentration of TNF-α, PGE2 and nitric oxide were measured
before and after treatment in both groups. All clinical parameters and inflammatory
biomarkers significantly reduced in gel and mouthwash group patients (p≤0.001) as
compared to patients received conventional treatment. The gel is found to be more
efficacious than mouthwash especially in reducing clinical attachment loss (p≤
0.05) and in reducing inflammatory biomarkers (p≤0.001). We strongly suggest the
use of metronidazole via local drug delivery system combined with scaling and root
planning to treat periodontal diseases.
AN - rayyan-563560097
AU - Hasan, F.
AU - Ikram, R.
AU - Abbas, A.
AU - Asadullah, K.
DO - 10.36721/PJPS.2020.33.5.REG.2053-2058.1
IS - 5
KW - gel
metronidazole
mouthwash
nitric oxide
prostaglandin E2
article
clinical article
controlled study
dental scaling
drug efficacy
female
gingival index
human
male
parallel design
periodontal disease
root planing
saliva level
tooth plaque
LA - English
PY - 2020
SN - 1011-601X
SP - 2053-2058
ST - Effectiveness of local drug delivery system using 1% metronidazole gel and
mouthwash in treating periodontal diseases
T2 - Pak. J. Pharma. Sci.
TI - Effectiveness of local drug delivery system using 1% metronidazole gel and
mouthwash in treating periodontal diseases
VL - 33
ID - 13471
ER -
TY - JOUR
AB - The idea of the local drug delivery system is getting popular nowadays to
treat gingivitis and periodontitis. The method of delivering the drug locally is
quite easy and requires minimal intervention. This delivery system not only treats
the periodontal diseases effectively but also prevents the side effects linked with
the use of the drugs which are used orally for longer periods to cure these
diseases. Chlorhexidine (CHX) is being widely used to treat these conditions
because of its broad spectrum anti-bacterial effect and is found to be more
effective in lowering plaque formation. The aim of this study was to appraise the
effect of the local drug delivery system by using 1% CHX gel in patients with
periodontal diseases. 1% CHX gel was prepared and its physicochemical
characteristics were then assessed. Clinical parameters and inflammatory salivary
biomarkers were evaluated in two groups of patients. Group I: standard treatment
group. Group II: gel treatment group. These parameters were evaluated before
treatment and after 4 weeks of treatment. 1% CHX gel was highly effective in
reducing gingivitis and periodontitis by using the local drug delivery system which
allowed the drug to retain into the periodontal pocket for prolong period of time.
AN - rayyan-563561254
AU - Hasan, F.
AU - Ikram, R.
AU - Adel, A.
AU - Abbas, A.
AU - Ain Bukhari, Q. U.
AU - Asadullah, K.
IS - 1
J2 - Pak J Pharm Sci
KW - Anti-Infective Agents, Local/*administration & dosage
Dinoprostone/analysis
Drug Delivery Systems/*methods
Gels
Gingivitis/drug therapy/metabolism
Humans
Mouthwashes/*administration & dosage
Periodontal Diseases/*drug therapy/metabolism
Periodontitis/drug therapy/metabolism
Saliva/chemistry/drug effects/metabolism
Treatment Outcome
Tumor Necrosis Factor-alpha/analysis
LA - eng
N1 - Department of Pharmacology, Fatima Jinnah Dental College, Karachi, Pakistan.;
Department of Pharmacology, Faculty of Pharmacy & Pharmaceutical Sciences,
University of Karachi, Karachi, Pakistan.; Department of Pharmacology, Jinnah
University for Women, Karachi, Pakistan.; Department of Pharmacology, Sir Syed
College of Medical Sciences, Karachi, Pakistan.; Department of Pharmacology, Sir
Syed College of Medical Sciences, Karachi, Pakistan.; Crown Dental Clinic, Karachi,
Pakistan.
PY - 2021
SN - 1011-601X (Print)
SP - 41-45
ST - Treatment of periodontal diseases by the local drug delivery system using 1%
chlorhexidine gel: A randomized clinical trial
T2 - Pakistan journal of pharmaceutical sciences
TI - Treatment of periodontal diseases by the local drug delivery system using 1%
VL - 34
Y2 - 1
ID - 14628
ER -
TY - JOUR
AB - The idea of the local drug delivery system is getting popular nowadays to
treat gingivitis and periodontitis. The method of delivering the drug locally is
quite easy and requires minimal intervention. This delivery system not only treats
the periodontal diseases effectively but also prevents the side effects linked with
the use of the drugs which are used orally for longer periods to cure these
diseases. Chlorhexidine (CHX) is being widely used to treat these conditions
because of its broad spectrum anti-bacterial effect and is found to be more
effective in lowering plaque formation. The aim of this study was to appraise the
effect of the local drug delivery system by using 1% CHX gel in patients with
periodontal diseases. 1% CHX gel was prepared and its physicochemical
characteristics were then assessed. Clinical parameters and inflammatory salivary
biomarkers were evaluated in two groups of patients. Group I: standard treatment
group. Group II: gel treatment group. These parameters were evaluated before
treatment and after 4 weeks of treatment. 1% CHX gel was highly effective in
reducing gingivitis and periodontitis by using the local drug delivery system which
allowed the drug to retain into the periodontal pocket for prolong period of time.
AN - rayyan-563560037
AU - Hasan, F.
AU - Ikram, R.
AU - Adel, A.
AU - Abbas, A.
AU - Bukhari, Q. U. A.
AU - Asadullah, K.
DO - 10.36721/PJPS.2021.34.1.REG.041-045.1
IS - 1
chlorhexidine
gel
nitric oxide
prostaglandin E2
adult
article
clinical article
controlled study
dental scaling
drug efficacy
gingivitis
human
Pakistan
periodontal disease
periodontitis
physical chemistry
saliva level
LA - English
PY - 2021
SN - 1011-601X
SP - 41-45
ST - Treatment of periodontal diseases by the local drug delivery system using 1%
TI - Treatment of periodontal diseases by the local drug delivery system using 1%
VL - 34
ID - 13411
ER -
TY - JOUR
AB - Simvastatin is an anti-hyperlipidemic drug which reduces the cholesterol
synthesis and also has anti-inflammatory, immunomodulatory and anti-microbial
action against the bacteria. This develops the interest of periodontologist to use
it in combination with conventional treatment to treat periodontal diseases. The
objective of the study was to develop the gel and mouthwash of simvastatin and use
it locally to treat gingivitis and periodontitis as an adjunct to scaling and root
planning. The patients were randomly allocated into three groups that were standard
treatment group, gel treatment group and mouthwash treatment group. Results
indicated that simvastatin gel and mouthwash in 1% preparation showed favorable
results by significantly reducing periodontal parameters and inflammatory
biomarkers (p≤ 0.001) as compared to standard treatment. Thus, we strongly suggest
the use of simvastatin by local drug delivery system as an adjunct treatment of
scaling and root planning.
AN - rayyan-563560217
AU - Hasan, F.
AU - Ikram, R.
AU - Simjee, S. U.
AU - Iftakhar, K.
AU - Asadullah, K.
DO - 10.36721/PJPS.2019.32.6.REG.2673-277.1
IS - 6
KW - gel
mouthwash
nitric oxide
prostaglandin E2
simvastatin
adult
article
clinical article
controlled study
dental scaling
drug efficacy
gingiva bleeding
gingival index
gingivitis
human
mucoadhesion
periodontitis
plaque index
tablet
viscosity
LA - English
PY - 2019
SN - 1011-601X
SP - 2673-2677
ST - Effectiveness of Simvastatin 1% oral gel and mouthwash used as an adjunct
treatment of scaling and root planning in the treatment of periodontal diseases
TI - Effectiveness of Simvastatin 1% oral gel and mouthwash used as an adjunct
treatment of scaling and root planning in the treatment of periodontal diseases
VL - 32
ID - 13591
ER -
TY - JOUR
AB - Inflammation and its mediators have an important role in gingivitis and
periodontitis. Prostaglandin is one of the eicosanoid involved in many chronic
inflammatory diseases, including periodontal diseases. Aspirin irreversibly
acetylates cyclooxygenase and inactivate this enzyme responsible for the production
of PGE2 that mediates pain and inflammation. The aim of the study was to prepare
aspirin gel and mouthwash in 1% concentration and use it in patients with
periodontal diseases during the non-surgical periodontal treatment and to assess
its anti-inflammatory effects on salivary biomarkers PGE2, TNF-α, and nitric oxide.
Thirty patients were divided into three treatment groups, standard treatment group,
second received scaling and root planning with gel application of 1% aspirin, third
received scaling and root planning followed by rinsing with 1% aspirin mouthwash.
Results indicated that the levels of PGE2, TNF-α and nitric oxide in the groups of
patients received gel treatment and mouthwash treatment was decreased to
significant levels (p≤ 0.001) as compared to the group of standard treatment.
Aspirin gel was found to be more effective in reducing inflammatory biomarkers in
contrast to aspirin mouthwash (p≤0.001). We concluded from our study, that low
concentration of aspirin oral preparations are highly active in reducing the
inflammatory biomarkers associated with periodontal diseases.
AN - rayyan-563560213
AU - Hasan, F.
AU - Ikram, R.
AU - Simjee, S. U.
AU - Iftakhar, K.
AU - Asadullah, K.
AU - Usman, M.
IS - 5
KW - acetylsalicylic acid
mouthwash
nitric oxide
propylene glycol
prostaglandin E2
adult
article
clinical article
controlled study
dental procedure
dental scaling
drug saliva level
gel
human
inflammation
periodontal disease
root planning
salivation
tooth pain
LA - English
PY - 2019
SN - 1011-601X
SP - 2019-2023
ST - The effects of aspirin gel and mouthwash on levels of salivary biomarkers
PGE2, TNF-α and nitric oxide in patients with periodontal diseases
TI - The effects of aspirin gel and mouthwash on levels of salivary biomarkers
PGE2, TNF-α and nitric oxide in patients with periodontal diseases
VL - 32
ID - 13587
ER -
TY - JOUR
AN - rayyan-563561491
AU - Hassan, M. L.
AU - Abou-Elesoud, W. S.
AU - Safwat, E. M.
AU - Hassan, E. A.
AU - Fadel, S. M.
AU - Labeeb, A. M.
DO - 10.1007/s10570-022-04864-4
IS - 18
PY - 2022
SP - 9511-9529
ST - Effect of cellulose nanocrystals on rheology, liquid crystal, and delivery
behavior of metronidazole poloxamer-based in-situ dental medication
T2 - Cellulose
TI - Effect of cellulose nanocrystals on rheology, liquid crystal, and delivery
behavior of metronidazole poloxamer-based in-situ dental medication
85139704650&doi=10.1007%2fs10570-022-04864-
4&partnerID=40&md5=2e6c3637c9848c741af8d08478d7e937
VL - 29
ID - 14865
ER -
TY - JOUR
AB - AIM: This study aims to evaluate the effect of using combined calcium
hydroxide (Ca(OH)2 )/silver nanoparticles (AgNPs) or Ca(OH)2 individually as
intracanal medications in reducing post-operative pain and intracanal bacterial
count. MATERIALS AND METHODS: Thirty patients with necrotic mandibular anterior
teeth were randomly divided into three groups; Ca(OH)2 + AgNPs or AgNPs gel
(intervention groups) or Ca(OH)2 (control group). Patients received a standard 2-
visit endodontic treatment and recorded their pain levels after 4, 24, 48, 72, and
96 h following the first and second visit on a modified visual analog scale.
Intracanal bacterial counts were assessed using culturing before and after
instrumentation and intracanal medication. Outcome data were statistically analyzed
using Kruskal–Wallis and Fisher’s exact tests to compare between the groups and
Friedman’s test to assess the changes by time. RESULTS: At 24 h interappointment,
the incidence of pain was statistically significant (p = 0.005) as well as at 48 h
(p = 0.001). There was a statistically significant difference between the mean
percentage reduction of anaerobic bacterial counts in the three groups with the
highest percentage in the Ca(OH)2 + AgNPs group at 98.9% followed by AgNPs group
98.5% and Ca(OH)2 at 85.3% (p < 0.001). CONCLUSIONS: Combined Ca(OH)2 /AgNPs
reduced the intracanal bacterial counts significantly, but adversely affected the
interappointment pain. Based on that finding, this combination should be tested in
different concentrations with different ratios to reach the most effective
combination that reduces pain with high antibacterial efficacy.
AN - rayyan-563560048
AU - Hassan, N.
AU - Diab, A.
AU - Ahmed, G.
DO - 10.3889/oamjms.2021.6503
KW - adseal
DU 650
extraoral X ray system
JEM 2100 TEM
calcium hydroxide
dental material
epinephrine
resin
silver nanoparticle
adjuvant therapy
adult
article
bacterial clearance
bacterial count
biofilm
clinical article
colony forming unit
controlled study
debridement
DNA replication
drug formulation
electron microscopy
endodontics
female
follow up
human
male
pain assessment
pH
postoperative pain
prevalence
protein synthesis
robot-assisted prostatectomy
sample size
surface property
tooth root canal
visual analog scale
Promax 3D
LA - English
PY - 2021
SN - 1857-9655
SP - 248-256
ST - Post-operative pain and antibacterial efficacy of silver nanoparticles
formulations intracanal medication: A randomized controlled clinical study
T2 - Open Access Maced. J. Med. Sci.
TI - Post-operative pain and antibacterial efficacy of silver nanoparticles
formulations intracanal medication: A randomized controlled clinical study
VL - 9
ID - 13422
ER -
TY - JOUR
AB - Injectable hydrogels attract more attention to hard tissue engineering for
the fulfilment of the defects with irregular shapes. Therefore, the researchers
investigated the biocompatibility and immune response to the injectable PCL-PEG-
PCL-Col/nHA hydrogels in a mouse model. The histological examination was done via
H&E. The activation of the immune cells was evaluated by using antibodies against
the CD68, CD4, and CD8 markers. The expression of CCL-2, BCL-2, IL-10, and CD31
genes was measured. Moreover, serum levels of the ALT, ALP, AST, and Urea were
detected. The results of the chemical analysis showed that the collagen and Nano-
hydroxyapatite were successfully integrated into the PCL-PEG-PCL hydrogels. The
histological examination revealed a delayed biodegradation rate after the addition
of the collagen and Nano-hydroxyapatite. No prominent pro-inflammatory response was
found at the site of the injection. There are no significant differences in the
levels of the CD68 and CD8/CD4 lymphocyte ratio among groups (p >.05). The
expression of the CD31, IL-10 was significantly increased in the
PCL-PEG-PCL-Col/nHA hydrogel (p <.05). ALT, ALP, AST, and Urea levels were not
altered pre- and post-transplantation of the hydrogels (p >.05). These in vivo
results demonstrated that the injectable PCL-PEG-PCL-Col/nHA hydrogels are
biocompatible and suitable for further research in hard tissue regeneration.
AN - rayyan-563560036
AU - Hassanzadeh, A.
AU - Ashrafihelan, J.
AU - Salehi, R.
AU - Rahbarghazi, R.
AU - Firouzamandi, M.
AU - Ahmadi, M.
AU - Khaksar, M.
AU - Alipour, M.
AU - Aghazadeh, M.
DO - 10.1080/21691401.2021.1877153
IS - 1
KW - chemical analyzer
immunofluorescence assay kit
RNA purification kit
tissue scaffold
alizarin red s
CD4 antigen
CD68 antigen
CD8 antigen
collagen
gentamicin
hydrogel
interleukin 10
ketamine
nanohydroxyapatite
platelet endothelial cell adhesion molecule 1
polycaprolactone
protein bcl 2
secondary lymphoid tissue chemokine
tramadol
urea
xylazine
alanine aminotransferase blood level
alkaline phosphatase blood level
animal experiment
animal tissue
article
aspartate aminotransferase blood level
controlled study
histology
immunofluorescence
male
mouse
nonhuman
nuclear magnetic resonance spectroscopy
polymerization
protein expression
RNA extraction
synthesis
tissue engineering
urea blood level
X ray diffraction
LA - English
PY - 2021
SN - ["2169-141X", "2169-1401"]
SP - 136-146
ST - Development and biocompatibility of the injectable collagen/nano-
hydroxyapatite scaffolds as in situ forming hydrogel for the hard tissue
engineering application
T2 - Artif. Cells Nanomed. Biotechnol.
TI - Development and biocompatibility of the injectable collagen/nano-
hydroxyapatite scaffolds as in situ forming hydrogel for the hard tissue
engineering application
VL - 49
ID - 13410
ER -
TY - JOUR
AB - AIM: The aim of this study was to evaluate the efficacy of three different
local drug delivery medications in the treatment of chronic periodontitis.
MATERIALS AND METHODS: Sixty participants, aged 30-55 years, were involved in the
current research. Participants who fulfilled the inclusion criteria entered the
study and were allocated at random to one of the three groups, each comprising 20
patients as: group A: Scaling and root planing (SRP) with local application of
doxycycline gel, group B: SRP with local application of tetracycline fibers, and
group C: SRP with local application of chlorhexidine gel. The plaque index (PI),
the gingival index (GI), and periodontal pocket depth (PPD) were documented at
baseline visit (prior to local drug delivery), and these indices were again
documented 30 and 90 days post-local drug delivery. RESULTS: At baseline, GI score
for doxycycline gel use decreased from 1.38 ± 0.05 to 0.94 ± 0.02, 1.36 ± 0.11 to
0.76 ± 0.19 for tetracycline fibers use, as well as from 1.38 ± 0.10 to 0.84 ± 0.21
for chlorhexidine gel use post 90 days. The PI value at baseline for doxycycline
gel use lessened from 1.26 ± 0.01 to 1.02 ± 0.06, 1.30 ± 0.14 to 0.82 ± 0.16 for
tetracycline fibers use, as well as 1.30 ± 0.22 to 0.98 ± 0.11 for chlorhexidine
gel use post 90 days. At baseline, PPD values for doxycycline gel use decreased
from 5.88 ± 0.24 to 3.72 ± 0.11, tetracycline fibers use lessened from 5.90 ± 0.09
to 3.02 ± 0.06, as well as for chlorhexidine gel group from 5.82 ± 0.18 to 3.44 ±
0.16 post 90 days. CONCLUSION: Within the limitations of the current research, it
may be inferred that tetracycline fibers exhibited somewhat superior enhancement to
chlorhexidine as well as doxycycline gel. CLINICAL SIGNIFICANCE: Local
administration of antibacterial agents in continued or regulated delivery
arrangement is employed to augment the actions of nonsurgical periodontal
management, and it may be likely to attain gingival well-being by eliminating the
requirement for invasive methods with the aid of local drug delivery arrangements.
Chosen elimination or prohibition of microbial pathogens with locally administered
antibacterial agents coupled with SRP is an efficient move toward treatment of
chronic periodontitis.
AN - rayyan-563559747
AU - Hatila, S.
AU - Lahiri, B.
AU - Sunnanguli, G.
AU - Jayachandran, M.
AU - Gopakumar, R.
AU - Devi, K. B.
AU - Kamil, M. A.
DO - 10.5005/jp-journals-10024-3455
IS - 3
chlorhexidine
doxycycline
tetracycline
adult
controlled study
dental scaling
human
middle aged
procedures
root planing
LA - English
PY - 2023
SN - 1526-3711
SP - 162-167
ST - Comparative Assessment of the Effect of Three Various Local Drug Delivery
Medicaments in the Management of Chronic Periodontitis
TI - Comparative Assessment of the Effect of Three Various Local Drug Delivery
Medicaments in the Management of Chronic Periodontitis
VL - 24
ID - 13121
ER -
TY - JOUR
AB - Gingivitis and periodontitis resulting in early tooth loss represent a
serious problem in mentally handicapped persons. The effect of toothbrushing with a
chlorhexidine-containing gel on the gingival condition in a group of mentally
retarded was evaluated in a clinical trial. The results showed that chemical
control of dento-gingival bacterial deposits may represent a practical way of
improving oral hygiene in such groups.
AN - rayyan-563561195
AU - Hatle, G.
AU - Gjermo, P.
IS - 13
KW - chlorhexidine
hibitane dental gel
solidox
unclassified drug
central nervous system
gingivitis
mental deficiency
mouth
periodontitis
periodontosis
therapy
LA - Norwegian
PY - 1979
SN - 0029-2001
SP - 641-642+652
ST - The effect of a chlorhexidine-containing gel on the gingival condition in a
group of mentally handicapped subjects
T2 - TIDSSKR. NOR. LAEGEFOREN.
TI - The effect of a chlorhexidine-containing gel on the gingival condition in a
group of mentally handicapped subjects
VL - 99
ID - 14569
ER -
TY - JOUR
AB - The major cytotoxic activity of Moxa was extracted with CH2Cl2 and partially
purified by three cycles of silica gel column chromatography. The active fractions
showed higher cytotoxicity against six human tumor cell lines (two oral squamous
cell carcinoma, one salivary gland tumor, one melanoma, two leukemia) than three
normal oral human cells (gingival fibroblast, periodontal ligament fibroblast, pulp
cell). All fractions failed to protect the cells from the cytopathic effect induced
by HIV infection. ESR spectroscopy showed that all fractions produced little or no
radical under alkaline conditions, while showing much lower O2- scavenging
activity, generated by hypoxanthine-xanthine oxidase reaction, than antioxidants
and polyphenols. Active fractions induced DNA fragmentation in HL-60 cells, but
failed to modify the mobility and activity of mitochondrial Mn-containing
superoxide dismutase (MnSOD), in contrast to Moxa smoke. These data suggest that
the active principles in the Moxa extract might be different from that in Moxa
smoke, which produced carbon radical and modified MnSOD mobility and activity.
AN - rayyan-563560899
AU - Hatsukari, I.
AU - Hitosugi, N.
AU - Ohno, R.
AU - Nakamura, S.
AU - Mizukami, S.
AU - Nagasaka, H.
AU - Matsumoto, I.
AU - Kikuchi, H.
AU - Nishikawa, H.
AU - Niitsu, M.
AU - Kawase, M.
AU - Negoro, T.
AU - Satoh, K.
AU - Nakashima, H.
AU - Sakagami, H.
IS - 5
KW - antioxidant
cytotoxic agent
DNA fragment
hypoxanthine
manganese
methyl chloride
Moxa extract
plant extract
polyphenol
unclassified drug
xanthine oxidase
animal cell
article
cancer cell culture
cell protection
column chromatography
controlled study
cytopathogenic effect
cytotoxicity
drug isolation
drug purification
enzyme activity
human
human cell
Human immunodeficiency virus infection
mouse
moxa
nonhuman
plant
priority journal
smoke
LA - English
PY - 2002
SN - 0250-7005
SP - 2777-2782
ST - Partial purification of cytotoxic substances from Moxa extract
TI - Partial purification of cytotoxic substances from Moxa extract
VL - 22
ID - 14273
ER -
TY - JOUR
AB - Periodontal disease is defined as chronic inflammatory condition
characterized by the destruction of the periodontal tissues causing loss of
connective tissue attachment, loss of alveolar bone, and the formation of
pathological pockets around the diseased teeth. The use of systemic antibiotics has
been advocated for its treatment, but concerns emerged with respect to adverse drug
reactions and its contribution to bacterial resistance. Thus local drug delivery
devices have been developed that aim to deliver a high concentration of
antimicrobial drugs directly to the affected site, while minimizing drug's systemic
exposure. A burst release of antimicrobial agent from carrier, resulting in a short
and inadequate exposure of bacteria residing in periodontal pocket to the agent,
remains the main challenge of current local delivery systems for the treatment of
periodontal disease. This review aims to investigate and compare different local
antimicrobial delivery systems with regard to the treatment of periodontal disease.
© 2013 Controlled Release Society.
AN - rayyan-563560438
AU - Hau, H.
AU - Rohanizadeh, R.
AU - Ghadiri, M.
AU - Chrzanowski, W.
DO - 10.1007/s13346-013-0171-x
IS - 3
calcium phosphate dibasic
cement
doxycycline
ibuprofen
metronidazole
tetracycline
timolol maleate
alveolar bone
antibiotic therapy
comparative study
connective tissue
drug exposure
drug formulation
drug release
gel
human
nonhuman
periodontal disease
periodontal pocket
periodontitis
priority journal
review
systemic therapy
elyzol
LA - English
PY - 2014
SN - ["2190-3948", "2190-393X"]
SP - 295-301
ST - A mini-review on novel intraperiodontal pocket drug delivery materials for
the treatment of periodontal diseases
T2 - Drug Deliv. Transl. Res.
TI - A mini-review on novel intraperiodontal pocket drug delivery materials for
the treatment of periodontal diseases
VL - 4
ID - 13812
ER -
TY - JOUR
AN - rayyan-563561803
AU - Havaldar, V. D.
AU - Ghorpade, V. S.
AU - Mali, K. K.
AU - Gaikwad, V. K.
AU - Kumbhar, D. M.
DO - 10.7324/JAPS.2016.601028
IS - 10
PY - 2016
SP - 200-209
ST - Development and evaluation of in-situ gel containing ornidazole loaded
microspheres for treatment of periodontitis
T2 - Journal of Applied Pharmaceutical Science
TI - Development and evaluation of in-situ gel containing ornidazole loaded
microspheres for treatment of periodontitis
84996939085&doi=10.7324%2fJAPS.2016.601028&partnerID=40&md5=fc96c74b68a582a711f407f
190fe3eeb
VL - 6
ID - 15177
ER -
TY - JOUR
AB - PURPOSE: This study was designed to investigate the effect of intramarrow
penetration (IMP) and 1% melatonin (MLN) gel on the remodelling process of
autogenous bone graft (ABG) in an induced 1-osseous wall defect model. METHODS:
Sixty-four intrabony induced mandibular defects were created on the distal side of
premolars-P1, P2, P3, and P4 (on each side)-in 8 beagle dogs. A ligature-induced
periodontitis was initiated in each defect. Defects were then divided into 4 equal
groups. Group I was treated with open-flap debridement (OFD) alone, group II was
treated with OFD/ABG, group III was treated with OFD/IMP/ABG, and group IV was
treated with OFD/ABG/IMP/1% MLN gel. The study parameters were bone fill,
histologic analysis, and immunohistochemical evaluation of endothelial nitric oxide
synthase (eNOS) expression at 2-week (2W) and 8-week (8W) time intervals. RESULTS:
At 8W, significant differences were revealed amongst all groups regarding the
amount of bone fill and eNOS expressions (P < .001). Bone fill percentages were
55.5%, 22.3%, 16.8%, and 0% in groups IV, III, II, and I, respectively. eNOS
expressions were 1.68 ± 0.06, 8.43 ± 0.04, 16.80 ± 0.17, and 1.97 ± 0.07 in groups
IV, III, II, and I, respectively. The favourable results were in line with group
IV. CONCLUSIONS: According to these preliminary results, defects treated by ABG
augmented with IMP and 1% MLN gel revealed a greater amount of bone fill and
reduced eNOS expression. This combination is therefore highly suggested as an
adjunct to ABG.
AN - rayyan-563559691
AU - Hazzaa, H. H.
AU - Attia, M. S.
AU - Shiekh, M. A. M. E.
AU - Grawish, M. E.
AU - Ghoneim, M. M. I.
AU - Adly, N. M.
AU - Shams, N. S.
AU - El-Mahdy, M. A.
AU - Elewa, G. M.
DO - 10.1016/j.identj.2022.11.003
IS - 4
KW - melatonin
alveolar bone loss
animal
dog
human
treatment outcome
LA - English
PY - 2023
SN - 1875-595X
SP - 524-532
ST - Use of Melatonin/Decorticotomy and Autogenous Bone Graft in Induced 1-Wall
Defect
T2 - Int Dent J
TI - Use of Melatonin/Decorticotomy and Autogenous Bone Graft in Induced 1-Wall
Defect
VL - 73
ID - 13065
ER -
TY - JOUR
AB - The purpose of this study was to evaluate the anti-gingivitis effectiveness
of a 0.454% stannous fluoride test dentifrice relative to a marketed positive-
control triclosan-containing dentifrice in adults with gingivitis. This was a two-
month, randomized and controlled, double-blind, parallel group, single-center
investigation involving 150 adults with existing mild to moderate gingivitis. Pre-
treatment gingivitis levels were assessed at baseline using the Lobene Modified
Gingival Index (MGI) and the Gingival Bleeding Index (GBI). Qualified subjects were
randomly assigned to either a 0.454% stannous fluoride test dentifrice or a
marketed, positive-control 0.30% triclosan/copolymer dentifrice. Subjects then
brushed for two months unsupervised in the home setting with their assigned
dentifrice per manufacturer's instructions. At Month 2, subjects were re-evaluated
for gingivitis via MGI and GBI examinations. All 150 enrolled subjects completed
the trial and were evaluable. Both the stannous fluoride test and
triclosan/copolymer control dentifrices provided statistically significant
reductions in average MGI, GBI, and number of bleeding sites relative to pre-
treatment (p < 0.0001) at Month 2. The adjusted mean improvement from baseline at
Month 2 for the stannous fluoride test dentifrice group was 65% greater for number
of bleeding sites, 62% greater for GBI, and 45% greater for MGI compared to the
triclosan/copolymer positive-control group, with groups differing significantly (p
< 0.0001) via each of the three gingivitis measures. Both dentifrices were well-
tolerated. An advanced stannous fluoride test dentifrice provided superior
reductions in gingival inflammation and gingival bleeding compared to a
commercially available triclosan/copolymer positive-control dentifrice after two
months of tooth brushing.
AN - rayyan-563560515
AU - He, T.
AU - Barker, M. L.
AU - Biesbock, A. R.
AU - Sharma, N. C.
AU - Qaqish, J.
AU - Goyal, C. R.
IS - 3
phosphate
polyvinylmethoxyethylene maleic anhydride copolymer
polyvinylmethoxyethylene-maleic anhydride copolymer
silicic acid
tin fluoride
toothpaste
triclosan
adolescent
adult
aged
article
chemistry
clinical trial
comparative study
controlled study
drug combination
female
gingivitis
human
male
middle aged
periodontics
prospective study
LA - English
PY - 2012
SN - 0895-8831
SP - 80-85
ST - Assessment of the effects of a stannous fluoride dentifrice on gingivitis in
a two-month positive-controlled clinical study
T2 - J Clin Dent
TI - Assessment of the effects of a stannous fluoride dentifrice on gingivitis in
a two-month positive-controlled clinical study
VL - 23
ID - 13889
ER -
TY - JOUR
AB - Purpose: To evaluate the anti-gingivitis benefits of a 0.454% highly
bioavailable stannous fluoride dentifrice (SnF2) relative to a 0.3%
triclosan/copolymer dentifrice (triclosan/copolymer) among triclosan/copolymer
dentifrice users with residual gingivitis. Methods: This was a randomized,
controlled, double-blind, parallel group, 2-month clinical study. Self-reported
triclosan/copolymer dentifrice users were recruited and provided with
triclosan/copolymer dentifrice to use for 1 month. After this 1-month acclimation
period, subjects who had residual gingivitis at the baseline visit were randomized
to either the SnF2 dentifrice or the triclosan/copolymer dentifrice (positive
control). Subjects performed their treatment unsupervised using their assigned
dentifrice following manufacturers' usage instructions for 2 months. The Gingival
Bleeding Index (GBI) and Modified Gingival Index (MGI) were used to measure
gingivitis benefits at baseline and Month 2. An analysis of covariance was
performed to compare treatment groups for the post-baseline scores as well as
change from baseline, with the baseline score as a covariate. All comparisons were
two-sided at the 0.05 level of significance. Results: A total of 150 subjects were
randomized to treatment. Both treatment groups experienced significant reductions
in number of bleeding sites, gingival bleeding index (GBI), and gingival
inflammation (MGI) relative to baseline (P< 0.001). At Month 2, the SnF2 dentifrice
group demonstrated significantly lower adjusted mean scores versus the
triclosan/copolymer group for number of bleeding sites, GBI, and MGI (P< 0.001).
Between-treatment group comparisons for change from baseline values showed that the
improvement in number of bleeding sites from baseline for the SnF2 group was 49%
greater versus that of the triclosan/copolymer group (P< 0.001), and the GBI and
MGI improvements from baseline for the SnF2 group were 48% and 37%, greater,
respectively, relative to the triclosan/copolymer group (P< 0.001).
AN - rayyan-563560506
AU - He, T.
AU - Barker, M. L.
AU - Biesbrock, A.
AU - Miner, M.
AU - Amini, P.
AU - Ram Goyal, C.
AU - Qaqish, J.
IS - 4
phosphate
silicic acid
tin fluoride
toothpaste
triclosan
adult
aged
article
bioavailability
comparative study
controlled study
female
follow up
gingiva bleeding
gingivitis
human
male
methodology
middle aged
periodontics
tooth brushing
young adult
LA - English
PY - 2013
SN - 0894-8275
SP - 175-179
ST - Evaluation of anti-gingivitis benefits of stannous fluoride dentifrice among
triclosan dentifrice users
T2 - Am. J. Dent.
TI - Evaluation of anti-gingivitis benefits of stannous fluoride dentifrice among
triclosan dentifrice users
VL - 26
ID - 13880
ER -
TY - JOUR
AB - As part of the human gastrointestinal tract, the oral cavity represents a
complex biological system and harbors diverse bacterial species. Unlike the gut
microbiota, which is often considered a health asset, studies of the oral commensal
microbiota have been largely limited to their implication in oral conditions such
as dental caries and periodontal disease. Less emphasis has been given to their
potential beneficial roles, especially the protective effects against oral
colonization by foreign or pathogenic bacteria. In this study, we used salivary
microbiota derived from healthy human subjects to investigate protective effects
against colonization and integration of Pseudomonas aeruginosa, an opportunistic
bacterial pathogen, into developing or pre-formed salivary biofilms. When co-
cultivated in saliva medium, P. aeruginosa persisted in the planktonic phase, but
failed to integrate into the salivary microbial community during biofilm formation.
Furthermore, in saliva medium supplemented with sucrose, the oral microbiota
inhibited the growth of P. aeruginosa by producing lactic acid. More interestingly,
while pre-formed salivary biofilms were able to prevent P. aeruginosa colonization,
the same biofilms recovered from mild chlorhexidine gluconate treatment displayed a
shift in microbial composition and showed a drastic reduction in protection. Our
study indicates that normal oral communities with balanced microbial compositions
could be important in effectively preventing the integration of foreign or
pathogenic bacterial species, such as P. aeruginosa. © 2011 John Wiley & Sons A/S.
AN - rayyan-563560570
AU - He, X.
AU - Hu, W.
AU - He, J.
AU - Guo, L.
AU - Lux, R.
AU - Shi, W.
DO - 10.1111/j.2041-1014.2011.00622.x
IS - 6
KW - bacterial DNA
lactic acid
sucrose
adult
article
bacterial growth
bacterial viability
bacterium culture
bacterium isolate
biofilm
cell aggregation
coculture
controlled study
human
mass spectrometry
microbial community
mouth flora
nonhuman
normal human
saliva
LA - English
PY - 2011
SN - ["2041-1006", "2041-1014"]
SP - 337-352
ST - Community-based interference against integration of Pseudomonas aeruginosa
into human salivary microbial biofilm
TI - Community-based interference against integration of Pseudomonas aeruginosa
into human salivary microbial biofilm
VL - 26
ID - 13944
ER -
TY - JOUR
AB - The candidate phylum TM7 is globally distributed and often associated with
human inflammatory mucosal diseases. Despite its prevalence, the TM7 phylum remains
recalcitrant to cultivation, making it one of the most enigmatic phyla known. In
this study, we cultivated a TM7 phylotype (TM7x) from the human oral cavity. This
extremely small coccus (200-300 nm) has a distinctive lifestyle not previously
observed in human-associated microbes. It is an obligate epibiont of an Actinomyces
odontolyticus strain (XH001) yet also has a parasitic phase, thereby killing its
host. This first completed genome (705 kb) for a human-associated TM7 phylotype
revealed a complete lack of amino acid biosynthetic capacity. Comparative genomics
analyses with uncultivated environmental TM7 assemblies show remarkable conserved
gene synteny and only minimal gene loss/gain that may have occurred as TM7x adapted
to conditions within the human host. Transcriptomic and metabolomic profiles
provided the first indications, to our knowledge, that there is signaling
interaction between TM7x and XH001. Furthermore, the induction of TNF-innodataalpha
production in macrophages by XH001 was repressed in the presence of TM7x,
suggesting its potential immune suppression ability. Overall, our data provide
intriguing insights into the uncultivability, pathogenicity, and unique lifestyle
of this previously uncharacterized oral TM7 phylotype.
AN - rayyan-563560392
AU - He, X.
AU - McLean, J. S.
AU - Edlund, A.
AU - Yooseph, S.
AU - Hall, A. P.
AU - Liu, S. Y.
AU - Dorrestein, P. C.
AU - Esquenazi, E.
AU - Hunter, R. C.
AU - Cheng, G.
AU - Nelson, K. E.
AU - Lux, R.
AU - Shi, W.
DO - 10.1073/pnas.1419038112
IS - 1
KW - essential amino acid
RNA 16S
streptomycin
Actinomyces
Actinomyces meyeri
Actinomyces naeslundii
Actinomyces odontolyticus
Actinomyces viscosus
amino acid synthesis
article
Bdellovibrio
Bdellovibrio bacteriovorus
cell expansion
cell membrane
cell shape
coculture
coevolution
controlled study
cytokine production
endosymbiont
epibiont
Escherichia coli
eukaryote
gene expression
gene function
gene loss
gene sequence
genome
genome size
genomics
horizontal gene transfer
host
host range
human
human associated TM7 phylotype
Ignicoccus
immune response
macrophage
metabolomics
microscopy
mouth cavity
Nanoarchaeum equitans
nonhuman
nucleic acid base substitution
parasite
parasite cultivation
pathogenicity
periodontitis
phenotype
phylum
polyamine metabolism
potassium transport
RNA sequence
starvation
surface property
symbiont
synteny
transcriptomics
upregulation
vaginitis
LA - English
PY - 2015
SN - ["1091-6490", "0027-8424"]
SP - 244-249
ST - Cultivation of a human-associated TM7 phylotype reveals a reduced genome and
epibiotic parasitic lifestyle
T2 - Proc. Natl. Acad. Sci. U. S. A.
TI - Cultivation of a human-associated TM7 phylotype reveals a reduced genome and
epibiotic parasitic lifestyle
VL - 112
ID - 13766
ER -
TY - JOUR
AB - Guided tissue regeneration (GTR) strategies enable periodontal tissue
regeneration, generally by providing barrier membranes. However, currently
available membranes have limited osteoconductive and antibacterial potential. To
address these challenges, we fabricated a new asymmetric barrier membrane. Agarose
hydrogel functions as the main body of the barrier membrane. Hollow carbonated
hydroxyapatite (CHA) prepared by hydrothermal method, was sedimented in agarose to
exhibit an asymmetrical structure. And epsilon-poly-lysine (epsilon-PLL) was chosen
as an antimicrobial agent to equip the membrane with long-lasting antibacterial
activity. With the increased dose of CHA addition, the barrier membrane shows
better biocompatibility, and higher mechanical properties. We demonstrated the
osteoconductivity and antibacterial properties of the membrane in vitro and in
vivo. In summary, our findings suggest that the barrier membrane has good
osteoconductive and antibacterial properties, indicating its potential for
periodontal tissue engineering.
AN - rayyan-563562270
AU - He, Z. Q.
AU - Zhou, X. L.
AU - Wang, Y.
AU - Lin, J.
AU - Huang, S. Y.
AU - Hu, R. D.
AU - Zhou, Y. L.
AU - Qian, Q. P.
AU - Deng, H.
DO - 10.1016/j.carbpol.2021.118525
PY - 2021
SN - ["0144-8617", "1879-1344"]
ST - Asymmetric barrier membranes based on polysaccharide micro-nanocomposite
hydrogel: Synthesis, characterization, and their antibacterial and osteogenic
activities
T2 - CARBOHYDRATE POLYMERS
TI - Asymmetric barrier membranes based on polysaccharide micro-nanocomposite
activities
VL - 273
Y2 - 12 y3 - 1
ID - 15644
ER -
TY - JOUR
AB - Guided tissue regeneration (GTR) strategies enable periodontal tissue
regeneration, generally by providing barrier membranes. However, currently
available membranes have limited osteoconductive and antibacterial potential. To
address these challenges, we fabricated a new asymmetric barrier membrane. Agarose
hydrogel functions as the main body of the barrier membrane. Hollow carbonated
hydroxyapatite (CHA) prepared by hydrothermal method, was sedimented in agarose to
exhibit an asymmetrical structure. And ε-poly-lysine (ε-PLL) was chosen as an
antimicrobial agent to equip the membrane with long-lasting antibacterial activity.
With the increased dose of CHA addition, the barrier membrane shows better
biocompatibility, and higher mechanical properties. We demonstrated the
osteoconductivity and antibacterial properties of the membrane in vitro and in
vivo. In summary, our findings suggest that the barrier membrane has good
osteoconductive and antibacterial properties, indicating its potential for
periodontal tissue engineering.
AN - rayyan-563559940
AU - He, Z.
AU - Zhou, X.
AU - Wang, Y.
AU - Lin, J.
AU - Huang, S.
AU - Hu, R.
AU - Zhou, Y.
AU - Qian, Q.
AU - Deng, H.
DO - 10.1016/j.carbpol.2021.118525
biomaterial
hydroxyapatite
polylysine
polysaccharide
sepharose
bone development
bone regeneration
chemistry
drug effect
Escherichia coli
human
hydrogel
procedures
tissue engineering
LA - English
PY - 2021
SN - 1879-1344
SP - 118525
ST - Asymmetric barrier membranes based on polysaccharide micro-nanocomposite
activities
T2 - Carbohydr Polym
TI - Asymmetric barrier membranes based on polysaccharide micro-nanocomposite
activities
VL - 273
ID - 13314
ER -
TY - JOUR
AB - Objectives In the past few years stem cells were successfully isolated from
tooth associated tissues, which have multi-differentiation potential and
immunomodulatory effects. Conditions supporting the in vitro 3D proliferation and
differentiation of these cells may increase their applicability in clinical
processes. Amino acid-based hydrogels could mimic the properties of the native
extracellular matrix (ECM) and provide optimal conditions for the cells. Our aim is
to analyze dental pulp (DPSC), and periodontal ligament (PDLSC) derived stem cell
culture viability, morphology, proliferation and migration ability on various
poly(asparatic acid) based hydrogels (Zrinyi et al, Acta Biomater. 2013; 9:5122)
with different physico-chemical properties. Our long-term goal is to tailor these
properties to find the exquisite composition, which may subsequently be used in
regenerative therapy. Materials and methods Cells are originated from impacted
human wisdom teeth according to our previously published protocols (Kadar et al.,
Journal of Physiology and Pharmacology, 2009. 60(Suppl 7): p. 167-175.). The cells
were seeded on the PASP (polyaspartic acid) based hydrogels. We examined 21
different gels that have different mechanical properties and contain different
amino-acid cross-linkers such as diaminobutan (DAB), cystamin (CYS) and lysine
(LYS) and some of them also contain different amounts of thiol groups. The gels
were pretreated with stem cell culture medium and were sterilized before the
seeding. We used 5 internal and at least 4 biological parallels in each experiment.
The morphology of the cells was examined by phase-contrast microscope for 7 days.
Proliferation and migration kinetics were monitored by videomicroscopy for 24
hours. To visualize the cells growing into the gels, they were labeled with the
fluorescent vital dye Vybrant DiD. The examination was carried out with two-photon
microscopy on the second and the 4th day. For analyzing cell viability, we used a
mitochondrial dehydrogenase activity-based method applying WST-1 reagent, on the
second and the 4th day after plating. Results While our cells are able to attach
and grow on DAB and CYS cross-linked PASP-based hydrogels, they were unable to do
so on LYS cross-linked gels. The attached cells show healthy, fibroblast-like
morphology. DPSC and PDLSC cells were viable on DAB and CYS gels, while we cannot
find viable cells on the LYS cross-linked gels. The highest population of viable
cells could be observed when cultivating them on PASP gels containing thiol groups.
The increase of the amount of thiol-groups in the gels had a significant positive
effect on the adhesion and the proliferation of the DPSC and PDLSC cells. We found
that the increase of the hardness of the gel also increased the adhesion and the
proliferation of the cells. Phase-contrast and two-photon microscopic analysis also
confirmed these results and showed that these cells were able to grow inside the
gel matrix in the case of DAB and CYS cross-linked gels. Conclusions The thiol-
containing PASP gels is found to be most suitable for culturing PDL and DP
originated stem cell cultures, since they ensure the conditions for adhering,
reproduction and migration. These gels would be good candidates as scaffolds in
stem cell-based tissue engineering.
AN - rayyan-563560371
AU - Hegedus, O.
AU - Juriga, D.
AU - Nagy, K.
AU - Jedlovszky-Hajdu, A.
AU - Zrinyi, M.
AU - Varga, G.
IS - 7
KW - acid
thiol group
amino acid
lysine
methenamine
polyaspartic acid
dye
oxidoreductase
thiol
stem cell
hydrogel
tooth
morphology
stem cell culture
human
photon
adhesion
culture medium
in vitro study
gel
pharmacology
cell viability
phase contrast microscope
physiology
tooth pulp
microscopy
molar tooth
examination
video microscopy
kinetics
fibroblast
population
therapy
hardness
tissue engineering
tissues
LA - English
PY - 2015
SN - 1746-0751
SP - 39
ST - Tooth-derived stem cell culturing on poly(asparatic acid) based hydrogels
T2 - Regen. Med.
TI - Tooth-derived stem cell culturing on poly(asparatic acid) based hydrogels
VL - 10
ID - 13745
ER -
TY - JOUR
AB - Aim: To compare the effectiveness of two anti-infective protocols for the
treatment of peri-implant mucositis. Materials and methods: Twenty-nine patients
with one implant diagnosed with peri-implant mucositis (bleeding on probing [BOP]
with no loss of supporting bone) were randomly assigned to a control or test group.
Following an assessment of baseline parameters (probing depth, BOP, suppuration,
presence of plaque), all patients received non-surgical mechanical debridement at
the implant sites and were instructed to brush around the implant twice daily using
a gel provided for a period of 4 weeks. The test group (15 patients) received a
chlorhexidine gel (0.5%), and the control group (14 patients) received a placebo
gel. The study was performed double blind. After 4 weeks, patients were instructed
to discontinue using the gel and to continue with routine oral hygiene at the
implant sites. Baseline parameters were repeated at 1 and 3 months. Results: At 1
month, there was a statistically significant reduction in the mean number of sites
with BOP and mean probing depth measurements at implants in both groups. There were
also some statistically significant changes in these parameters from 1 to 3 months.
However, there were no statistically significant differences between test and
control groups. One month following treatment, 76% of implants had a reduction in
BOP. Complete resolution of BOP at 3 months was achieved in 38% of the treated
implants. The presence of a submucosal restoration margin resulted in significantly
lower reductions in probing depth following treatment. Conclusions: Non-surgical
debridement and oral hygiene were effective in reducing peri-implant mucositis, but
did not always result in complete resolution of inflammation. Adjunctive
chlorhexidine gel application did not enhance the results compared with mechanical
cleansing alone. Implants with supramucosal restoration margins showed greater
therapeutic improvement compared with those with submucosal restoration margins. ©
2011 John Wiley & Sons A/S.
AN - rayyan-563560601
AU - Heitz-Mayfield, L. J. A.
AU - Salvi, G. E.
AU - Botticelli, D.
AU - Mombelli, A.
AU - Faddy, M.
AU - Lang, N. P.
DO - 10.1111/j.1600-0501.2010.02078.x
IS - 3
KW - chlorhexidine
placebo
article
clinical trial
comparative study
controlled study
female
follow up
gel
gingiva bleeding
human
male
methodology
middle aged
mouth hygiene
multicenter study
periimplantitis
periodontal pocket
periodontics
smoking
suppuration
tooth brushing
tooth plaque
treatment outcome
LA - English
PY - 2011
SN - ["0905-7161", "1600-0501"]
SP - 237-241
ST - Anti-infective treatment of peri-implant mucositis: A randomised controlled
clinical trial
T2 - Clin. Oral Implants Res.
TI - Anti-infective treatment of peri-implant mucositis: A randomised controlled
clinical trial
VL - 22
ID - 13975
ER -
TY - CONF
AN - rayyan-563562096
AU - Hench, L. L.
DA - 2006
DO - 10.1007/s10856-006-0432-z
ET - 11
SP - 967-978
ST - The story of Bioglass®
T2 - Journal of Materials Science: Materials in Medicine
TI - The story of Bioglass®
33751501700&doi=10.1007%2fs10856-006-0432-
z&partnerID=40&md5=c1d59ecce531c32e01e4711866e7097f
VL - 17
ID - 15470
ER -
TY - JOUR
AB - Historically the function of biomaterials has been to replace diseased or
damaged tissues. First generation biomaterials were selected to be as bio-inert as
possible and thereby minimize formation of scar tissue at the interface with host
tissues. Bioactive glasses were discovered in 1969 and provided for the first time
an alternative; second generation, interfacial bonding of an implant with host
tissues. Tissue regeneration and repair using the gene activation properties of
Bioglass® provide a third generation of biomaterials. This article reviews the 40
year history of the development of bioactive glasses, with emphasis on the first
composition, 45S5 Bioglass®, that has been in clinical use since 1985. The steps of
discovery, characterization, in vivo and in vitro evaluation, clinical studies and
product development are summarized along with the technology transfer processes. ©
2006 Springer Science + Business Media, LLC.
AN - rayyan-563560756
AU - Hench, L. L.
DO - 10.1007/s10856-006-0432-z
IS - 11
KW - biomaterial
calcium oxide
glass
Hermes antigen
silicon dioxide
silver
somatomedin
somatomedin B
auditory ossicle
bacteriostasis
biocompatibility
bone
bone prosthesis
bone strength
bone transplantation
cell cycle
cell death
cell fate
cell proliferation
ceramics
chemical reaction
conduction deafness
conference paper
edentulism
gel
genetic regulation
human
hypothesis
molecular model
nonhuman
osteoblast
periodontal disease
priority journal
research
soft tissue
technology
tissue engineering
tissue regeneration
Bioglass
DOUEK MED
ERMI
MEP
NovaBone
PerioGlas
LA - English
PY - 2006
SN - 0957-4530
SP - 967-978
ST - The story of Bioglass®
TI - The story of Bioglass®
VL - 17
ID - 14130
ER -
TY - JOUR
AB - To prevent caries and periodontal disease in overdenture abutment teeth,
daily application of chlorhexidine gel is recommended. In order to get insight into
the use of the gel, 29 overdenture wearing patients were interviewed. In addition
the patients were requested to show the use of the gel. It was concluded that at
any time the patients were instructed about the use of the gel. Nevertheless, a
majority of the patients did not use the gel daily and in accordance with the
instructions given. Application of the gel in the abutment depressions of the
overdenture appeared to be a heavy task.
AN - rayyan-563560994
AU - Hendrikx, M. J.
AU - Kramer, J. E.
AU - de Baat, C.
IS - 3
KW - chlorhexidine
adult
aged
article
denture
female
gel
human
male
methodology
microbiology
middle aged
mouth hygiene
Netherlands
patient compliance
questionnaire
statistics
LA - Dutch
PY - 2000
SN - 0028-2200
SP - 94-96
ST - Overdentures covering natural roots. The use of chlorhexidine gel
T2 - Overkappingsprothesen op natuurlijke pijlers. Het gebruik van
chloorhexidinegel.
TI - Overdentures covering natural roots. The use of chlorhexidine gel
VL - 107
ID - 14368
ER -
TY - JOUR
AB - Tooth brushing is considered a superior technique for reducing plaque
accumulation. Chemical agents may be used to reduce plaque accumulation on tooth
surfaces since many owners may not be willing or able to brush their dog's teeth.
Following a professional teeth cleaning procedure, a dental gel containing
chlorhexidine was applied in 11 dogs BID for 7-days, while 11 other dogs received a
control dental gel applied in the same manner. Dogs in the treatment group had
significantly less plaque accumulation during the trial period compared with dogs
in the control group. The dental gel applied in the study reported here decreases
plaque accumulation in the short-term and may be beneficial in reducing the
severity of gingivitis and associated periodontal disease if provided on a long-
term basis.
AN - rayyan-563560912
AU - Hennet, P.
DO - 10.1177/089875640201900101
IS - 1
KW - chlorhexidine
toothpaste
animal
animal disease
article
clinical trial
controlled study
dog
dog disease
female
gel
mouth hygiene
periodontics
tooth plaque
treatment outcome
LA - English
PY - 2002
SN - 0898-7564
SP - 11-14
ST - Effectiveness of a dental gel to reduce plaque in beagle dogs
T2 - J Vet Dent
TI - Effectiveness of a dental gel to reduce plaque in beagle dogs
VL - 19
ID - 14286
ER -
TY - JOUR
AB - Ischemic heart disease considers the myocardial infarction (MI), either non-
ST-segment elevation (non-STEMI) or ST-segment elevation myocardial infarction
(STEMI); this represents the main cause of mortality in Mexican population.
Regarding to the inflammatory state, this is reported to be a major prognostic
factor of mortality for patients with MI. One of the conditions capable of
producing systemic inflammation is periodontal disease. It has been proposed that
the oral microbiota is translocated through the bloodstream to the liver and
intestine, generating intestinal dysbiosis. The aim of this protocol is to assess
oral microbiota diversity and circulating inflammatory profile in STEMI patients
stratified according to an inflammation-based risk scoring system. We found that
Bacteriodetes phylum was the most abundant in STEMI patients, and Prevotella was
the most abundant genus, with a higher proportion in periodontitis patients. In
fact, Prevotella genus was found to correlate positively and significantly with
elevated IL-6 concentration. Our study defined a non-causal association inferred
between the cardiovascular risk of STEMI patients, determined by changes in the
oral microbiota that influence the development of periodontal disease and its
relationship with the exacerbation of the systemic inflammatory response.
AN - rayyan-563559765
AU - Hernández-Ruiz, P.
AU - Amezcua-Guerra, L. M.
AU - López-Vidal, Y.
AU - González-Pacheco, H.
AU - Pinto-Cardoso, S.
AU - Amedei, A.
AU - Aguirre-García, M. M.
DO - 10.3389/fcimb.2023.1095380
KW - AU680
ChemiDoc
clinical chemistry analyzer
DxH900
flow cytometer
LEGENDplex
spectrophotometer
albumin
C reactive protein
gamma interferon
interleukin 10
interleukin 12p70
interleukin 17
interleukin 1beta
interleukin 2
interleukin 4
interleukin 6
interleukin 8
RNA 16S
transforming growth factor beta receptor 1
troponin
troponin I
tumor necrosis factor alpha receptor
acute coronary syndrome
adult
article
Bacteroides
Bacteroidetes
bleeding
blood sampling
body mass
cardiovascular risk
clinical article
controlled study
cytokine production
DNA extraction
dysbiosis
electrocardiography
erythema
female
Firmicutes
Fusobacteria
gingivitis
Haemophilus
heart catheterization
heart infarction
human
illumina sequencing
inflammation
ischemic heart disease
male
metagenomics
microbial community
microbial diversity
microbiome
mortality rate
observational study
periodontal disease
plaque index
Prevotella
principal component analysis
Proteobacteria
pyrosequencing
questionnaire
risk assessment
risk factor
ST segment elevation myocardial infarction
stone analysis
stratification
swelling
systemic inflammatory response syndrome
validation study
FACSAria
Nanodrop 1000
LA - English
PY - 2023
SN - 2235-2988
ST - Comparative characterization of inflammatory profile and oral microbiome
according to an inflammation-based risk score in ST-segment elevation myocardial
infarction
TI - Comparative characterization of inflammatory profile and oral microbiome
according to an inflammation-based risk score in ST-segment elevation myocardial
infarction
VL - 13
ID - 13139
ER -
TY - JOUR
AN - rayyan-563561722
AU - Hernawati, S.
AU - Zikra, Y. A.
AU - Fatmawati, D. W. A.
DO - 10.20473/j.djmkg.v52.i2.p90-94
IS - 2
PY - 2019
SP - 90-94
ST - The effects of topical application of red pomegranate (Punica granatum Linn)
extract gel on the healing process of traumatic ulcers in Wistar rats
T2 - Dental Journal
TI - The effects of topical application of red pomegranate (Punica granatum Linn)
extract gel on the healing process of traumatic ulcers in Wistar rats
85088021209&doi=10.20473%2fj.djmkg.v52.i2.p90-
94&partnerID=40&md5=6258ee39691d027955ed31a79698a51b
VL - 52
ID - 15096
ER -
TY - JOUR
AN - rayyan-563561806
AU - Herrera, D.
DO - 10.1016/j.jebdp.2016.01.005
IS - 1
PY - 2016
SP - 56-58
ST - Scaling and Root Planning is Recommended in the Nonsurgical Treatment of
Chronic Periodontitis
T2 - Journal of Evidence-Based Dental Practice
TI - Scaling and Root Planning is Recommended in the Nonsurgical Treatment of
Chronic Periodontitis
84966656254&doi=10.1016%2fj.jebdp.2016.01.005&partnerID=40&md5=78c2bd7d4d0a3977e907
c2c4ec2cc7ad
VL - 16
ID - 15180
ER -
TY - JOUR
AB - Endodontic therapy is indicated for cases of traumatic tooth dislocation
associated with pulp necrosis and/or inflammatory resorption. Here we describe the
management of a maxillary left lateral permanent incisor that suffered lateral
luxation, leading to pulp necrosis and root resorption, in a 13-year-old boy. The
traumatized tooth was treated successfully by intracanal medication with calcium
hydroxide, 2% chlorhexidine gel and zinc oxide for 12 months without any need to
change the dressing, followed by conventional root canal filling. The postoperative
course was uneventful and a stable clinical outcome was obtained with evidence of
periapical lesion repair and stabilization of the resorption process.
AN - rayyan-563560414
AU - Herrera, D. R.
AU - Herrera, C. M.
AU - Lima, A. R.
AU - Nagata, J. Y.
AU - Pereira, A. C.
AU - Silva, E. J.
AU - Soares, A. J.
AU - Gomes, B. P.
IS - 4
bismuth
calcium hydroxide
chlorhexidine
MTA-Angelus
oxide
silicate
tooth cement
zinc oxide
adolescent
case report
complication
tooth pulp disease
follow up
human
incisor
injury
male
pathology
procedures
root canal obturation
tooth disease
tooth apex
tooth discoloration
tooth fracture
tooth injury
treatment outcome
LA - English
PY - 2014
SN - 1880-4926
SP - 311-314
ST - Repair of apical root resorption associated with periodontitis using a new
intracanal medicament protocol
T2 - J Oral Sci
TI - Repair of apical root resorption associated with periodontitis using a new
intracanal medicament protocol
VL - 56
ID - 13788
ER -
TY - JOUR
AB - Biofilms play a pivotal role in the progression of periodontitis and they can
be treated with antiseptics (i.e. chlorhexidine) or antibiotics, but these
therapeutic alternatives are unable of ameliorating periodontal alveolar bone loss,
which has been, on the other hand, successfully treated with bone-preserving
agents. The improved bone formation achieved in animal models by the combination of
two such agents: bioactive glass (BAG) and bisphosphonates has attracted the
interest for further exploring dental applications. However, the antimicrobial
effects that may result from combining them have not been yet investigated. Here,
our aim was to explore the anti-biofilm effects that could result from combining
BAG with bisphosphonates, particularly in a dental biofilm model. The experiments
were performed with an oral cavity single-specie (Aggregatibacter
actinomycetemcomitans) biofilm assay, which was optimized in this contribution.
Risedronate displayed an intrinsic anti-biofilm effect, and all bisphosphonates,
except clodronate, reduced biofilm formation when combined with BAG. In particular,
the anti-biofilm activity of risedronate was significantly increased by the
combination with BAG. Since it has been proposed that some of the antimicrobial
effects of BAG are caused by local pH changes, studies of pH variations were
performed to gain a mechanistic understanding. However, the observed anti-biofilm
effects could not be explained with lowered pHs. Overall, these results do provide
further support for the promising use of bisphosphonate-BAG combinations in dental
applications. These findings are particularly relevant for patients undergoing
cancer chemotherapy, or osteoporotic patients, which are known to be more
vulnerable to periodontitis. In such cases, bisphosphonate treatment could play a
double positive effect: local treatment of periodontitis (in combination with BAG)
and systemic treatment of osteoporosis, prevention of hypercalcemia and metastases.
(C) 2016 Elsevier B.V. All rights reserved.
AN - rayyan-563562359
AU - Hiltunen, A. K.
AU - Skogman, M. E.
AU - Rosenqvist, K.
AU - Juvonen, H.
AU - Ihalainen, P.
AU - Peltonen, J.
AU - Juppo, A.
AU - Fallarero, A.
DO - 10.1016/j.ijpharm.2016.02.006
IS - 1
PY - 2016
SN - ["0378-5173", "1873-3476"]
SP - 211-220
ST - Bioactive glass combined with bisphosphonates provides protection against
biofilms formed by the periodontal pathogen Aggregatibacter actinomycetemcomitans
TI - Bioactive glass combined with bisphosphonates provides protection against
biofilms formed by the periodontal pathogen Aggregatibacter actinomycetemcomitans
VL - 501
Y2 - 3 y3 - 30
ID - 15733
ER -
TY - JOUR
AB - The native GroEL-like protein was purified from Campylobacter rectus, a
putative periodontal pathogen, by affinity chromatography on ATP-agarose followed
by high performance liquid chromatography on Superose 6. The purified 64-kDa
protein (denatured form of GroEL-like protein) was immunoreactive by SDS-PAGE and
Western immunoblotting with the monoclonal antibody directed against heat shock
protein 60 of human origin. The native GroEL-like protein stimulated both
interleukin-6 (IL-6) and IL-8 secretion by a confluent monolayer of human gingival
fibroblast in their culture supernatant. During the 22-h incubation, the amounts of
IL-6 and IL-8 were increased by 5.4- and 3.5-fold, respectively. These data
suggested that the GroEL-like protein might be considered to be a virulence factor
of C. rectus in periodontal disease. Copyright (C) 1998 Federation of European
Microbiological Societies.
AN - rayyan-563561020
AU - Hinode, D.
AU - Yoshioka, M.
AU - Tanabe, S. I.
AU - Miki, O.
AU - Masuda, K.
AU - Nakamura, R.
DO - 10.1016/S0378-1097(98)00359-0
IS - 1
KW - interleukin 6
interleukin 8
protein
article
Campylobacter
fibroblast culture
gingiva
human
human cell
immunoblotting
immunoreactivity
priority journal
protein analysis
LA - English
PY - 1998
SN - 0378-1097
SP - 1-6
ST - The GroEL-like protein from Campylobacter rectus: Immunological
characterization and interleukin-6 and -8 induction in human gingival fibroblast
T2 - FEMS Microbiol. Lett.
TI - The GroEL-like protein from Campylobacter rectus: Immunological
characterization and interleukin-6 and -8 induction in human gingival fibroblast
VL - 167
ID - 14394
ER -
TY - JOUR
AB - Purpose: Chlorhexidine is an antimicrobial agent used in the prevention of
postextraction alveolar osteitis, tooth decay, and periodontal diseases. There are
various forms of chlorhexidine application. The most extensively studied is one
that uses the rinse as the form of application. Recently, a bioadhesive gel form
has become available. Its main advantage is that it prolongs the bioavailability of
chlorhexidine in the application area. The purpose of this study was to compare the
effectiveness of chlorhexidine gel versus a chlorhexidine rinse in reducing
postoperative alveolar osteitis after the extraction of mandibular third molars.
Materials and Methods: The experimental or gel group (n = 41) applied the
bioadhesive 0.2% chlorhexidine gel to the wound during the first postoperative week
and a control or rinse group (n = 32) used a 0.12% chlorhexidine rinse during the
first week postextraction. Results: We observed a 70% decrease in postoperative
alveolar osteitis in the gel group (P = .040). The rinse group had 25% incidence
postoperative alveolar osteitis, while the gel group had 7.5%. Conclusions: It was
concluded that the topical application of bioadhesive chlorhexidine gel to the
surgical wound during the postoperative week may decrease the incidence of alveolar
osteitis after extraction of the mandibular third molars. © 2008 American
Association of Oral and Maxillofacial Surgeons.
AN - rayyan-563560716
AU - Hita-Iglesias, P.
AU - Torres-Lagares, D.
AU - Flores-Ruiz, R.
AU - Magallanes-Abad, N.
AU - Basallote-Gonzalez, M.
AU - Gutierrez-Perez, J. L.
DO - 10.1016/j.joms.2007.06.641
IS - 3
KW - chlorhexidine
adult
alveolar bone
article
clinical trial
controlled study
drug effect
female
human
male
mandible
molar tooth
osteitis
LA - English
PY - 2008
SN - 0278-2391
SP - 441-445
ST - Effectiveness of Chlorhexidine Gel Versus Chlorhexidine Rinse in Reducing
Alveolar Osteitis in Mandibular Third Molar Surgery
T2 - J. Oral Maxillofac. Surg.
TI - Effectiveness of Chlorhexidine Gel Versus Chlorhexidine Rinse in Reducing
Alveolar Osteitis in Mandibular Third Molar Surgery
VL - 66
ID - 14090
ER -
TY - COMP
AB - PURPOSE: Chlorhexidine is an antimicrobial agent used in the prevention of
postextraction alveolar osteitis, tooth decay, and periodontal diseases. There are
various forms of chlorhexidine application. The most extensively studied is one
that uses the rinse as the form of application. Recently, a bioadhesive gel form
has become available. Its main advantage is that it prolongs the bioavailability of
chlorhexidine in the application area. The purpose of this study was to compare the
effectiveness of chlorhexidine gel versus a chlorhexidine rinse in reducing
postoperative alveolar osteitis after the extraction of mandibular third molars.
MATERIALS AND METHODS: The experimental or gel group (n = 41) applied the
bioadhesive 0.2% chlorhexidine gel to the wound during the first postoperative week
and a control or rinse group (n = 32) used a 0.12% chlorhexidine rinse during the
first week postextraction. RESULTS: We observed a 70% decrease in postoperative
alveolar osteitis in the gel group (P = .040). The rinse group had 25% incidence
postoperative alveolar osteitis, while the gel group had 7.5%. CONCLUSIONS: It was
concluded that the topical application of bioadhesive chlorhexidine gel to the
surgical wound during the postoperative week may decrease the incidence of alveolar
osteitis after extraction of the mandibular third molars.
AN - rayyan-563561374
AU - Basallote-Gonzalez, M.
CY - United States
DO - 10.1016/j.joms.2007.06.641
ET - 3
J2 - J Oral Maxillofac Surg
KW - Adolescent
Adult
Age Factors
Chi-Square Distribution
Contraceptives, Oral, Hormonal/adverse effects
Disinfectants/*administration & dosage
Dry Socket/*drug therapy/epidemiology/prevention & control
Female
Gels
Humans
Male
Middle Aged
Molar, Third/*surgery
Mouthwashes/*therapeutic use
Prospective Studies
Risk Factors
Sex Factors
Smoking/adverse effects
Tooth Extraction/adverse effects
LA - eng
N1 - Department of Oral and Maxillofacial Surgery, University of Michigan, Ann
Arbor, MI 48109-0018, USA. pilarh@umich.edu
PY - 2008
SP - 441-5
ST - Effectiveness of chlorhexidine gel versus chlorhexidine rinse in reducing
alveolar osteitis in mandibular third molar surgery
T2 - Journal of oral and maxillofacial surgery : official journal of the American
Association of Oral and Maxillofacial Surgeons
TI - Effectiveness of chlorhexidine gel versus chlorhexidine rinse in reducing
alveolar osteitis in mandibular third molar surgery
VL - 66
Y2 - 3
ID - 14748
ER -
TY - GEN
AB - Adequate dental and oral hygiene may become a challenge for all users and
especially for elderly people and young children because of their limited motor
skills. The same holds true for patients undergoing/recovering from
chemo-/radiotherapy with accompanying sensitive mucosal conditions. Poor dental
hygiene can result in tooth decay, gingivitis, periodontitis, tooth loss, bad
breath (halitosis), fungal infection and gum diseases. The use of a toothbrush is
the most important measure for oral hygiene. Toothbrushes with soft bristles
operated carefully by hand or via an electric device help to remove plaque and to
avoid mucosal trauma. A handlebar with a grip cover can be helpful for manually
disabled patients or for those with reduced motor skills. In case of oral hygiene
at the bedside or of patients during/after chemo-/radiotherapy a gauze pad can be
helpful for gently cleaning the teeth, gums and tongue. The use of fluoride
toothpaste is imperative for the daily oral hygiene. Detergents such as sodium
lauryl sulphate improve the cleaning action but may also dehydrate and irritate the
mucous membrane. The use of products containing detergents and flavouring agents
(peppermint, menthol, cinnamon) should therefore be avoided by bedridden patients
or those with dry mouth and sensitive mucosa. Aids for suitable interdental
cleaning, such as dental floss, interdental brushes or dental sticks, are often
complicated to operate. Their correct use should be instructed by healthcare
professionals. To support dental care, additional fluoridation with a fluoride gel
or rinse can be useful. Products further containing antiseptics such as
chlorhexidine or triclosan reduce the quantity of bacteria in the mouth. For
patients undergoing or having undergone radio-/chemotherapy, a mouthwash that
concomitantly moisturizes the oral mucosa is advisable. © 2011 S. Karger AG, Basel.
AN - rayyan-563560602
AU - Hitz Lindenmüller, I.
AU - Lambrecht, J. T.
CY - I. Hitz Lindenmüller, Clinic for Oral Surgery, Oral Radiology and Oral
Medicine, School of Dentistry, Basel University, Hebelstrasse 3, CH-4056 Basel,
Switzerland
DO - 10.1159/000321060
KW - chlorhexidine
fluoride
menthol
mouthwash
peppermint
toothpaste
triclosan
article
bacterial count
cancer chemotherapy
cancer patient
cancer radiotherapy
child
cinnamon
dental caries
dental floss
denture
disability
geriatric patient
gingiva disease
gingivitis
halitosis
human
motor performance
mouth hygiene
mycosis
nonhuman
patient care
periodontal disease
periodontitis
priority journal
scleroderma
toothbrush
LA - English
PY - 2011
SN - ["1421-5721", "9783805596152"]
SP - 107-115
ST - Oral care
T2 - Curr. Probl. Dermatol.
TI - Oral care
VL - 40
ID - 13976
ER -
TY - JOUR
AB - Local delivery of drug is a promising strategy to manage periodontitis
characterized by chronic inflammation of the soft tissue surrounding the teeth. An
optimized system should prolong the drug retention time and exhibit controlled drug
permeation through the buccal mucosal layer. This study was aimed to develop
hydroxyethyl cellulose (HEC)-based gel containing metronidazole (MTZ) loaded in
solid lipid nanoparticles (SLNs), and to enhance the antimicrobial activity of MTZ.
SLNs were prepared using a combination method of solvent evaporation and hot
homogenization. The results showed that the fabricated SLNs, comprising of Precirol
(2.93%, w/v), Tween 80 (1.8%, w/v), and the drug:lipid ratio of 19.3% (w/w), were
approximately 200 nm in size, with a narrow distribution. The HEC (3%, w/w)-based
gel formed a smooth, homogeneous structure and had preferable mechanical and
rheological properties. Moreover, the MTZ-loaded SLNs-based HEC gel (equivalent to
1% of MTZ, w/w) exhibited a sustained in vitro drug release pattern, optimal ex
vivo permeability, and enhanced in vitro antimicrobial activity after 24 h of
treatment. These findings indicate the potential of the MTZ-loaded SLNs-based HEC
formulation for local drug delivery at the buccal mucosa in managing periodontal
disease.
AN - rayyan-563559909
AU - Ho, H. N.
AU - Le, H. H.
AU - Le, T. G.
AU - Duong, T. H. A.
AU - Ngo, V. Q. T.
AU - Dang, C. T.
AU - Nguyen, V. M.
AU - Tran, T. H.
AU - Nguyen, C. N.
DO - 10.1016/j.ijbiomac.2021.11.161
KW - gel
glycerol palmitostearate
metronidazole
polysorbate 80
article
buccal drug administration
controlled study
drug formulation
drug penetration
drug release
drug solubility
ex vivo study
flow kinetics
in vitro study
particle size
periodontal disease
synthesis
LA - English
PY - 2022
SN - ["1879-0003", "0141-8130"]
SP - 1010-1018
ST - Formulation and characterization of hydroxyethyl cellulose-based gel
containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug
delivery
TI - Formulation and characterization of hydroxyethyl cellulose-based gel
containing metronidazole-loaded solid lipid nanoparticles for buccal mucosal drug
delivery
VL - 194
ID - 13283
ER -
TY - JOUR
AB - Bacterial biofilm in the oral cavity and around dental implants may trigger
an inflammatory response of the peri-implant soft tissue. Emerging antimicrobial
products have been developed to combat peri-implant soft tissue pathology; however,
limited evidence is available evaluating their effectiveness. To the best of the
authors'knowledge, this is the first documented case report in the literature
assessing the effect of Cervitec Plus around dental implants. This case report
provides an example of a patient presenting to a periodontal specialty clinic with
peri-implant pathology and subsequently treated with anti microbial varnish
following dental hygiene peri-implant therapy. The report serves to evaluate the
efficacy of peri-implant soft tissue pathology utilizing antimicrobial varnish as
measured by percent of bleeding upon probing, presence of suppuration, and changes
in implant probing depths. Understanding the impact of bacterial plaque on peri-
implant soft tissue and the effectiveness of antimicrobial products in conjunction
with dental hygiene peri-implant therapy may provide patients with optimal peri-
implant health and long-term success of dental implants.
AN - rayyan-563562432
AU - Hoerler, S. B.
AU - Salinas, T. J.
AU - Zhou, M. X.
DO - 10.3290/j.qi.b2644827
IS - 4
PY - 2022
SN - ["0033-6572", "1936-7163"]
SP - 314-318
ST - The influence of antimicrobial varnish on peri-implant soft tissue health:
case report
T2 - QUINTESSENCE INTERNATIONAL
TI - The influence of antimicrobial varnish on peri-implant soft tissue health:
case report
VL - 53
Y2 - 4
ID - 15806
ER -
TY - JOUR
AB - Objectives: The purpose of the clinical study was to determine the efficacy
of an intensive preventive program for children with renal insufficiency in
preventing gingivitis. Materials and methods: 36 children with chronic kidney
disease (CKD) grade 3 - 5 or renal transplants were recruited by pediatric
nephrologists. Patients were randomized to an intensive need-related preventive
program by software support (Tenalea). Depending on the degree of inflammation
professional tooth cleaning, local chlorhexidine gel, and rinse were key measures.
Treatment as usual according to the statutory health insurance (SHI) focusing on
motivation and instruction served as control. Intensive prophylactic procedures
were implemented in the control group after 3 months of observation. As primary
endpoint gingival inflammation was characterized by the papilla bleeding index and
the gingival index. Additionally the Quigley Hein plaque index was determined.
Results: The applied measures of the intensive preventive program have shown
clinically relevant and statistically significant reductions compared to statutory
treatment as usual. After the 1st appointment more than 50% reduction of the
gingival inflammation was achieved. Three to four sessions had been necessary to
reach complete elimination of inflammation. Despite the usual preventive
interventions (SHI) gingival inflammation was apparent until need related intensive
prophylactic procedures had been implemented after 3 months. Once prophylactic
treatment was established, absence of gingival inflammation was maintained over the
next 3 months. Conclusion: Children suffering from CKD are afflicted with
gingivitis despite usual preventive measures (SHI). A need-related intensive
preventive program is effective by almost eliminating gingival inflammation.
However, small signs of gingivitis after 3 months demonstrate the requirement of
regular need related appointments.
AN - rayyan-563560199
AU - Höfer, K.
AU - Witte, H.
AU - Thea, R.
AU - Turnowsky, A.
AU - Taylan, C.
AU - Weber, L. T.
AU - Noack, M.
DO - 10.5414/NHX02027
IS - 3
bleeding
child
clinical article
conference abstract
controlled study
dental prophylaxis
female
gingival index
gingivitis
health insurance
human
kidney graft
male
motivation
nephrologist
prevention
software
surgery
LA - English
PY - 2019
SN - 0300-5224
SP - 143
ST - Gingivitis prevention in children with renal insufficiency by a need-related
program
T2 - Nieren- Hochdruckkr.
TI - Gingivitis prevention in children with renal insufficiency by a need-related
program
VL - 48
ID - 13573
ER -
TY - JOUR
AB - OBJECTIVE: The aim: To study the effectiveness of chronic apical
periodontitis treatment by the combined use of ultrasonic treatment of root canals
and multicomponent antimicrobial gel according to the results of clinical and
microbiological researches. PATIENTS AND METHODS: Materials and methods: 64
patients with chronic apical periodontitis at the age of 18-56 years were treated.
Patients were divided into two groups: the main and control. In the main group the
root canals of 36 teeth were sonicated in combination with multicomponent
antimicrobial gel, in the control - 35 teeth were treated by a standard method. The
content of the root canals for microbiological studies was obtained before
endodontic treatment and before permanent obturation. Frequency of content and
number of bacteria in the samples were evaluated. RESULTS: Results: All samples
before treatment were positive for the presence of variable bacterial flora, among
which Staphylococcus epidermidis (43.9%), Enterococcus faecalis (37.9%),
Streptococcus spp. (24.8%), Candida albicans (24.4%), Fusibacterium (9.4%) were the
most dominant, their number was 7.4-4.8 lg CFU/ml. Repeated research after the
proposed and standard method of root canal decontamination has shown a significant
decrease in microflora. According to the data of clinical and microbiological
examination, the method which was developed by us revealed a positive result in 86%
of cases compared with 63% when treated by the standard method. CONCLUSION:
Conclusions: The effectiveness of a complex treatment method with combined use of
the ultrasonic irrigation and multicomponent antimicrobial gel for root canals
decontamination in chronic apical periodontitis is demonstrated. Significant
reduction of microflora growth and destruction of microbial associations, good
penetration of multicomponent antimicrobial gel into endodontic structures due to
ultrasound compared with a standard method were achieved.
AN - rayyan-563560160
AU - Horlenko, I. M.
AU - Gadzhula, N. G.
AU - Cherepakha, O. L.
AU - Kurdysh, L. F.
AU - Pylypiuk, O. Y.
IS - 6
KW - bacterium
decontamination
dental pulp cavity
human
LA - English
PY - 2020
SN - 0043-5147
SP - 1119-1123
ST - Clinical and microbiological assessment of root canal decontamination in
chronic apical periodontitis using the ultrasound
T2 - Wiad. Lek.
TI - Clinical and microbiological assessment of root canal decontamination in
chronic apical periodontitis using the ultrasound
VL - 73
ID - 13534
ER -
TY - JOUR
AB - Context: Local drug delivery (LDD) systems have been proposed for the
treatment of periodontitis. Curcumin could be a suitable agent as LDD for the
treatment of periodontitis. Aim: To formulate, evaluate the anti-inflammatory
activity and to assess the duration of the action and the efficacy of 2% curcumin
gel in the treatment of experimental periodontitis in Wistar albino rat model.
Settings and Design: Twenty-one Wistar albino rats were randomly assigned to three
groups. Periodontitis was induced using ligature model. Group 1: Control; group 2:
Plain gel, and group 3: 2% curcumin gel. Materials and Methods: About 2% curcumin
gel was prepared. The anti-inflammatory activity and duration of action was
assessed. Silk ligature 5-0 was used to induce periodontitis. Gingival index (GI)
and probing pocket depth (PPD) were measured. Treatment was done. The rats were
sacrificed. Morphometric analysis was performed using stereomicroscope and ImageJ
software. Statistical Analysis Used: Analysis of variance followed by Bonferroni′s
test, Wilcoxon′s test for inter-group comparison, Mann-Whitney test for P value
computation was used. The observations are mean ± standard deviation and standard
error of the mean. P < 0.01 when compared to control was considered as
statistically significant. Results: About 2% curcumin gel showed 42.98% inhibition
of edema and peak activity was noted at 24 h. There was statistically significant
change in the GI and PPD. Morphometric analysis did not show any significant
difference between groups. No toxic effects were seen on oral administration of
2000 mg/kg of curcumin. Conclusions: About 2% curcumin gel was effective in the
treatment of experimental periodontitis.
AN - rayyan-563560447
AU - Hosadurga, R. R.
AU - Rao, S.
AU - Jose, J.
AU - Rompicharla, N. C.
AU - Shakil, M.
AU - Shashidhara, R.
DO - 10.4103/0974-8490.138287
IS - 4
KW - benzoic acid
carbopol 940
curcumin
propylene glycol
triethanolamine
unclassified drug
voveron
animal experiment
animal model
article
controlled study
drug efficacy
drug formulation
evaluation study
female
gel
gingiva
male
morphometry
nonhuman
periodontitis
rat
LA - English
PY - 2014
SN - 0974-8490
SP - 326-333
ST - Evaluation of the efficacy of 2% curcumin gel in the treatment of
T2 - Pharmacogn. Res.
TI - Evaluation of the efficacy of 2% curcumin gel in the treatment of
VL - 6
ID - 13821
ER -
TY - JOUR
AB - Objectives: Carnosic acid (CA), which is one of bioactive compounds from
rosemary, has various biological activities. However, the effect of CA on
periodontal ligament cells is still uncertain. The aim of this study was to examine
the effects of CA on inflammatory cytokines production in human periodontal
ligament cells. Methods: Cytokine and chemokine levels were measured by ELISA.
Activations of signal transduction pathway were determined by Western blotting.
Results: Treatment of CA decreased inflammatory cytokines such as interleukin (IL)-
6, CXC chemokine ligand (CXCL)10, CC chemokine ligand (CCL)2, and CCL20 productions
in IL-1β or tumor necrosis factor (TNF)-α-stimulated human periodontal ligament
cells in a dose-dependent manner. Moreover, we found that CA could suppress Jun-N-
terminal kinase (JNK) pathway, nuclear factor (NF)-κB pathway and signal transducer
and activator of transcription (STAT)3 pathway activation in IL-1β or TNF-α-
stimulated human periodontal ligament cells. Conclusion: The results of this study
suggest that CA has anti-inflammatory effects in human periodontal ligament cells
by inhibiting JNK, NF-κB and STAT3 pathways.
AN - rayyan-563560112
AU - Hosokawa, I.
AU - Hosokawa, Y.
AU - Ozaki, K.
AU - Matsuo, T.
DO - 10.1080/08923973.2020.1782427
IS - 4
KW - carnosic acid
cytokine
interleukin 1beta
interleukin 6
Janus kinase
mitogen activated protein kinase p38
STAT3 protein
article
controlled study
cytokine production
enzyme activation
human
human cell
in vitro study
priority journal
signal transduction
Western blotting
LA - English
PY - 2020
SN - ["1532-2513", "0892-3973"]
SP - 373-378
ST - Carnosic acid inhibits inflammatory cytokines production in human periodontal
ligament cells
T2 - Immunopharmacol. Immunotoxicol.
TI - Carnosic acid inhibits inflammatory cytokines production in human periodontal
ligament cells
VL - 42
ID - 13486
ER -
TY - JOUR
AB - Interleukin-29 (IL-29) is a cytokine belonging to the Type III interferon
family. It was recently detected in the gingival crevicular fluid of periodontitis
patients. However, the role of IL-29 in the pathogenesis of periodontal disease
remains unknown. The aim of this study was to examine the effects of IL-29 on C-X-C
motif chemokine ligand 10 (CXCL10) production in human oral epithelial cells. We
measured CXCL10 production in TR146 cells, which is a human oral epithelial cell
line, using an enzyme-linked immunosorbent assay. We used a Western blot analysis
to detect IL-29 receptor expression and the phosphorylation levels of signal
transduction molecules, including p38 mitogen-activated protein kinases (MAPK),
signal transducer and activator of transcription 3 (STAT3), and nuclear factor
(NF)- κB p65, in the TR146 cells. The TR146 cells expressed the IL-29 receptor. IL-
29 induced CXCL10 production in the TR146 cells. IL-29 significantly enhanced
CXCL10 production in tumor necrosis factor (TNF)-α-stimulated TR146 cells. The p38
MAPK, STAT3, and NF-κB pathways were found to be related to the IL-29-induced
enhancement of CXCL10 production in TNF-α-stimulated TR146 cells. IL-29 promotes T
helper 1-cell accumulation in periodontal lesions by inducing CXCL10 production in
oral epithelial cells.
AN - rayyan-563560291
AU - Hosokawa, Y.
AU - Hosokawa, I.
AU - Shindo, S.
AU - Ozaki, K.
AU - Matsuo, T.
DO - 10.1080/08820139.2017.1336176
IS - 6
KW - gamma interferon inducible protein 10
interleukin 10
interleukin 28
interleukin 29
STAT3 protein
article
cell lysate
human
human cell
mouth epithelium cell
periodontal disease
priority journal
signal transduction
Th1 cell
Western blotting
LA - English
PY - 2017
SN - ["1532-4311", "0882-0139"]
SP - 615-624
ST - IL-29 Enhances CXCL10 Production in TNF-α-stimulated Human Oral Epithelial
Cells
T2 - Immunol. Invest.
TI - IL-29 Enhances CXCL10 Production in TNF-α-stimulated Human Oral Epithelial
Cells
VL - 46
ID - 13665
ER -
TY - JOUR
AB - Purpose: Novel drug delivery systems (DDSs) hold great promise for the
treatment of oral cavity diseases. The main objective of this article was to
provide a detailed overview regarding recent advances in the use of novel and
nanostructured DDSs in alleviating and treating unpleasant conditions of the oral
cavity. Strategies to maximize the benefits of these systems in the treatment of
oral conditions and future directions to overcome these issues are also discussed.
Methods: Publications from the last 10 years investigating novel and nanostructured
DDSs for pathologic oral conditions were browsed in a systematic search using the
PubMed/MEDLINE, Web of Science, and Scopus databases. Research on applications of
novel DDSs for periodontitis, oral carcinomas, oral candidiasis, xerostomia, lichen
planus, aphthous stomatitis, and oral mucositis is summarized. A narrative
exploratory review of the most recent literature was undertaken. Findings:
Conventional systemic administration of therapeutic agents could exhibit high
clearance of drugs from the bloodstream and low accumulation at the target site. In
contrast, conventional topical systems face problems such as short residence time
in the affected region and low patient compliance. Novel and nanostructured DDSs
are among the most effective and commonly used methods for overcoming the problems
of conventional DDSs. The main advantages of these systems are that they possess
the ability to protect active agents from systemic and local clearance, enhance
bioavailability and cellular uptake, and provide immediate or modified release of
therapeutic agents after administration. In the design of local drug delivery
devices such as nanofiber mats, films, and patches, components and excipients can
significantly affect factors such as drug release rate, residence time in the oral
cavity, and taste in the mouth. Choosing appropriate additives is therefore
essential. Implications: Local drug delivery devices such as nanofiber mats,
nanoparticles, liposomes, hydrogels, films, and patches for oral conditions can
significantly affect drug efficacy and safety. However, more precise clinical
studies should be designed and conducted to confirm promising in vitro and in vivo
results. In recent years, novel and nanostructured DDSs increasingly attracted the
attention of researchers as a means of treatment and alleviation of oral diseases
and unpleasant conditions. However, more clinical studies should be performed to
confirm promising in vitro and in vivo results. To transform a successful
laboratory model into a marketable product, the long-term stability of prepared
formulations is essential. Also, proper scale-up methods with optimum preparation
costs should be addressed.
AN - rayyan-563559936
AU - Hosseinpour-Moghadam, R.
AU - Mehryab, F.
AU - Torshabi, M.
AU - Haeri, A.
DO - 10.1016/j.clinthera.2021.10.016
IS - 12
KW - drug delivery device
amphotericin
amphotericin B
aurantiin
ciclopiroxolamine
ciprofloxacin
clotrimazole
curcumin
cyclosporine
diclofenac
diclofenac potassium
doxorubicin
doxycycline
erythropoietin
eugenol
excipient
fluconazole
hematoporphyrin
histatin 5
hydrogel
insulin
ketoprofen
lidocaine
liposome
metronidazole
minocycline
nanofiber
nanomaterial
nanoparticle
paclitaxel
phthalocyanine aluminum
pilocarpine
propolis
rebamipide
retinoic acid
tinidazole
triamcinolone
ubidecarenone
ursolic acid
aphthous stomatitis
bacterial infection
bioavailability
drug clearance
drug release
drug safety
human
in vitro study
lichen planus
mouth carcinoma
mouth disease
new drug application
oral mucositis
patient compliance
periodontitis
publication
retention time
review
systematic review
thrush
xerostomia
LA - English
PY - 2021
SN - ["1879-114X", "0149-2918"]
SP - e377-e402
ST - Applications of Novel and Nanostructured Drug Delivery Systems for the
Treatment of Oral Cavity Diseases
T2 - Clin. Ther.
TI - Applications of Novel and Nanostructured Drug Delivery Systems for the
Treatment of Oral Cavity Diseases
VL - 43
ID - 13310
ER -
TY - JOUR
AB - Aims: To investigate the effects of an egg yolk-derived immunoglobulin (IgY)
specific to Prevotella intermedia in vitro and in vivo. Methods and Results: An IgY
specific to P. intermedia was produced by immunizing hens with formaldehyde-
inactivated P. intermedia and showed high titres when subjected to an ELISA. The
obtained IgY inhibited the growth of P. intermedia in a dose-dependent manner at
concentrations from 1 to 20 mg ml-1 in Center for Disease Control and Prevention
liquid medium. Forty rats were challenged with P. intermedia on gingivae and then
randomly divided into four groups, which were syringed respectively with phosphate-
buffered saline, 1 mg ml-1 of tinidazole, 20 mg ml-1 of nonspecific IgY and 20 mg
ml-1 of the IgY specific to P. intermedia at a dosage of 300 μl per day. Gingival
index (GI), plaque index (PI), bleeding on probing (BOP), counts of white blood
cell (WBC) and histopathological slide of the gums were measured after treatment
for 15 days. The gingivitis rats treated with the IgY specific to P. intermedia
showed significantly decreased GI, PI, BOP and WBC (P < 0·05). Gum histopathology
of the treated rats demonstrated a superior protective effect of the specific IgY
on P. intermedia-mediated gingivitis. Conclusions: A new immunoglobulin specific to
P. intermedia was developed from egg yolk. This specific IgY can dose-dependently
inhibit the growth of P. intermedia and protect rats from gingivitis induced by P.
intermedia. Significance and Impact of the Study: The new IgY has potential for the
treatment of P. intermedia-mediated gingivitis. © 2013 The Society for Applied
Microbiology.
AN - rayyan-563560449
AU - Hou, Y. Y.
AU - Zhen, Y. H.
AU - Wang, D.
AU - Zhu, J.
AU - Sun, D. X.
AU - Liu, X. T.
AU - Wang, H. X.
AU - Liu, Y.
AU - Long, Y. Y.
AU - Shu, X. H.
DO - 10.1111/jam.12419
IS - 4
KW - formaldehyde
immunoglobulin Y
tinidazole
animal experiment
animal model
animal tissue
antibody specificity
antibody titer
article
controlled study
gingiva bleeding
gingivitis
Gram negative infection
histopathology
immunization
in vitro study
in vivo study
liquid culture
nonhuman
protection
rat
tooth plaque
LA - English
PY - 2014
SN - ["1365-2672", "1364-5072"]
SP - 1020-1027
ST - Protective effect of an egg yolk-derived immunoglobulin (IgY) against
Prevotella intermedia-mediated gingivitis
T2 - J. Appl. Microbiol.
TI - Protective effect of an egg yolk-derived immunoglobulin (IgY) against
Prevotella intermedia-mediated gingivitis
VL - 116
ID - 13823
ER -
TY - JOUR
AB - Degradation of type I collagen by Porphyromonas gingivalis was monitored by
fluorogenic, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE),
and growth assays. All three assays showed that inactivation of both the rgpA and
rgpB genes was necessary to completely eliminate the capacity of P. gingivalis to
cleave type I collagen. Leupeptin, an Arg-gingipain-specific protease inhibitor,
almost completely inhibited collagen degradation by P. gingivalis cells whereas
cathepsin B inhibitor II, a Lys-gingipain inhibitor, did not. A purified
preparation of Arg-gingipains A and B hydrolyzed gelatin but did not cleave type I
collagen, suggesting that the enzymes must be attached to the cell surface to exert
collagenase activity. A number of substances used as adjuncts in periodontal
therapy were also tested for their capacity to inhibit collagenase activity of P.
gingivalis. Tetracycline, doxycycline, and chlorhexidine strongly inhibited
collagenase activity. © 2003 Federation of European Microbiological Societies.
Published by Elsevier Science B.V. All rights reserved.
AN - rayyan-563560885
AU - Houle, M. A.
AU - Grenier, D.
AU - Plamondon, P.
AU - Nakayama, K.
DO - 10.1016/S0378-1097(03)00178-2
IS - 2
KW - chlorhexidine
collagenase
doxycycline
gingipain R
leupeptin
metronidazole
penicillin G
tetracycline
article
bacterial cell
bacterial gene
drug mechanism
enzyme activity
enzyme degradation
enzyme inhibition
nonhuman
priority journal
LA - English
PY - 2003
SN - 0378-1097
SP - 181-185
ST - The collagenase activity of Porphyromonas gingivalis is due to Arg-gingipain
TI - The collagenase activity of Porphyromonas gingivalis is due to Arg-gingipain
VL - 221
ID - 14259
ER -
TY - JOUR
AB - Periodontal disease represents a group of oral inflammatory infections
initiated by oral pathogens which exist as a complex biofilms on the tooth surface
and cause destruction to tooth supporting tissues. The severity of this disease
ranges from mild and reversible inflammation of the gingiva (gingivitis) to chronic
destruction of connective tissues, the formation of periodontal pocket and
ultimately result in loss of teeth. While human subgingival plaque harbors more
than 500 bacterial species, considerable research has shown that Porphyromonas
gingivalis, a Gram-negative anaerobic bacterium, is the major etiologic agent which
contributes to chronic periodontitis. This black-pigmented bacterium produces a
myriad of virulence factors that cause destruction to periodontal tissues either
directly or indirectly by modulating the host inflammatory response. Here, this
review provides an overview of P. gingivalis and how its virulence factors
contribute to the pathogenesis with other microbiome consortium in oral cavity.
AN - rayyan-563560354
AU - How, K. Y.
AU - Song, K. P.
AU - Chan, K. G.
DO - 10.3389/fmicb.2016.00053
KW - fimbria protein
gingipain R
immunoglobulin
interleukin 1
interleukin 1alpha
interleukin 6
interleukin 8
lipid A
lipopolysaccharide
outer membrane protein A
plasminogen activator inhibitor 1
protein tyrosine phosphatase
proteinase
proteinase activated receptor 2
very late activation antigen 5
virulence factor
artery dilatation
bacterial capsule
fermentation
gingiva disease
host susceptibility
human
immunization
inflammation
microbiome
mouth flora
mouth plaque
nonhuman
periodontium
protein expression
review
LA - English
PY - 2016
SN - 1664-302X
ST - Porphyromonas gingivalis: An overview of periodontopathic pathogen below the
gum line
TI - Porphyromonas gingivalis: An overview of periodontopathic pathogen below the
gum line
VL - 7
ID - 13728
ER -
TY - JOUR
AB - The effect of zinc sulfadiazine (ZnSD) and silver sulfadiazine (AgSD) on
developing plaque formation and gingivitis was studied in 12 beagle dogs over a 14-
week period. Plaque and gingival indices were used to measure plaque formation and
gingivitis. During a 2-wk baseline period each dog was brought to optimal gingival
health with prophylaxis and tooth brushing. Thereafter, 4 dogs were treated twice
daily with topical application of 3.0% zinc sulfadiazine; 4 dogs were treated with
2.0% silver sulfadiazine while 4 dogs treated with placebo gel served as controls
over a 12-wk treatment period. At wk 2 of treatment, all three groups of dogs
showed an increase in plaque build-up on their teeth from baseline. By wk 6, plaque
accumulation on the teeth was significantly less in dogs treated with either ZnSD
or AgSD compared to control dogs. At wk 2 of treatment, gingival inflammation was
increased from baseline in all three groups. Thereafter, over the course of the 12-
wk treatment period, gingival inflammation in the ZnSD and the AgSD treated dogs
was significantly less than the placebo treated dogs. The data indicate that both
ZnSD and AgSD inhibit developing plaque formation in beagles. This significant
inhibition of plaque formation was accompanied by a significant reduction in
gingival inflamation.
AN - rayyan-563561169
AU - Howell, T. H.
AU - Reddy, M. S.
AU - Weber, H. P.
AU - Li, K. L.
AU - Alfano, M. C.
AU - Vogel, R.
AU - Tanner, A. C. R.
DO - 10.1111/j.1600-0765.1990.tb00904.x
IS - 4
KW - sulfadiazine silver
sulfadiazine zinc
animal
animal experiment
article
dog
gingivitis
mammal
methodology
nonhuman
tooth plaque
LA - English
PY - 1990
SN - 0022-3484
SP - 197-200
ST - Sulfadiazines prevent plaque formation and gingivitis in beagles
TI - Sulfadiazines prevent plaque formation and gingivitis in beagles
VL - 25
ID - 14543
ER -
TY - JOUR
AB - The effect of zinc sulfadiazine (ZnSD) and silver sulfadiazine (AgSD) on
reducing plaque formation and gingivitis was studied in 12 beagle dogs over a 14-
week period. 12 Beagle dogs were scaled, root planed and pumices to bring them to a
similar level of gingival health, prior to placing them on a diet of Purina Dog
Chow softened with canned gravy and molasses to promote the build-up of plaque and
the initiation of gingivitis. At the end of 8 weeks, the dogs were determined to
have substantial bacterial plaque accumulation and apparent gingivitis. Thereafter,
4 dogs were treated 2x daily with topical applictions of 3% zinc sulfadiazine; 4
dogs were treated with 2% silver sulfadiazine while 4 dogs were treated with
placebo gel serving as control over a 14-week treatment period. By week 2, the zinc
and silver sulfadiazine dogs showed a significant decrease in gingival index which
was maintained throughout the study. Additionally, by week 2, the % of sites with
bleeding was also seen to decrease significantly in the experimental groups. The
plaque index remained consistent in all 3 groups until week 6 when the 2
experimental groups indicated significant decrease in plaque accumulation as
compared to controls. Probing depths were also seen to decrease significantly in
the experimental groups after 10 weeks of therapy. The mean stain index was similar
in all 3 groups of dogs throughout the study. Data indicate that both zinc and
silver sulfadiazine inhibit plaque formation and reduce existing gingivitis in
beagle dogs.
AN - rayyan-563561166
AU - Howell, T. H.
AU - Reddy, M. S.
AU - Weber, H. P.
AU - Li, K. L.
AU - Alfano, M. C.
AU - Vogel, R.
AU - Tanner, A. C. R.
IS - 10
KW - sulfadiazine silver
sulfadiazine zinc
animal
animal experiment
article
dog
gingivitis
mammal
methodology
nonhuman
tooth plaque
LA - English
PY - 1990
SN - 0303-6979
SP - 734-737
ST - Sulfadiazines reduce gingivitis and plaque formation in beagle dogs
TI - Sulfadiazines reduce gingivitis and plaque formation in beagle dogs
VL - 17
ID - 14540
ER -
TY - JOUR
AN - rayyan-563561205
AU - Hoyos, D. F.
AU - Murray, J. J.
AU - Shaw, L.
IS - 11
chlorhexidine
placebo
adolescent
article
child
clinical trial
comparative study
female
gel
gingivitis
human
male
mouth hygiene
periodontics
tooth discoloration
tooth plaque
LA - English
PY - 1977
SN - 0007-0610
SP - 366-369
ST - The effect of chlorhexidine gel on plaque and gingivitis in children
T2 - Br Dent J
TI - The effect of chlorhexidine gel on plaque and gingivitis in children
VL - 142
ID - 14579
ER -
TY - JOUR
AB - Plant products have been extensively investigated for their application in
the treatment of periodontitis owing to their therapeutic benefits with no major
side effects. Further, increasing antimicrobial resistance associated with a
constant intake of synthetic antimicrobials has led to a change in paradigm towards
the use of phytochemical based formulations as antimicrobial therapy in
periodontitis. With this background, our present investigation focuses on
developing a novel thermoreversible gel of green tea extract (GT) which is well
known for its antimicrobial and antioxidant potential. In the first stage, the
antimicrobial activity of GT was assessed against a panel of microbes (S. mutans,
P. gingivalis, P. intermedia, F. nucleatum and A. actinomycetemcomitans).
Antimicrobial activity of GT extract showed MBC value of 1.25 w/v % with desirable
antiadhesion (34–69%) and antibiofilm activity (47–69%). In time kill assay, GT
demonstrated time dependent killing varying sensitivity against tested pathogens.
In the second stage, based on the MBC value, the thermoreversible gel of GT (GTTG)
was formulated using thermosensitive polymer poloxamer 407 (19.5% w/v) and
mucoadhesive polymer carbopol 934 (0.4%w/v). Formulated GTTG showed gelation
temperature of 29 ± 1 °C, gelation time of 44.67 ± 1.15 s, gelation strength of 45
± 1 g, the viscosity of 1659 ± 86 cPs and mucoadhesive strength of 1960 dyne/cm2.
GTTG showed maximum release and permeation of marker phytochemical Epigallocatechin
gallate in 48 and 96 h respectively. Finally, formulated GTTG when compared with
gold standard antiplaque agent chlorhexidine gel for its antimicrobial potential
showed greater zone of inhibition (ZOI) when tested against key periodontal
pathogen P. gingivalis. Hence, the formulated novel GTTG could serve as an
effective alternative local drug delivery with ease of administration and accurate
dosing for the treatment of periodontitis.
AN - rayyan-563559802
AU - Hr, R.
AU - Jagwani, S.
AU - Shenoy, P. A.
AU - Jadhav, K.
AU - Shaikh, S.
AU - Mutalik, S. P.
AU - Mullick, P.
AU - Mutalik, S.
AU - Jalalpure, S.
AU - Sikarwar, M. S.
AU - Dhamecha, D.
DO - 10.1016/j.jddst.2022.103765
KW - carbopol 934
chlorhexidine
epigallocatechin gallate
hydrogel
poloxamer
sinecatechins
article
controlled study
drug formulation
drug screening
gelation
mucoadhesion
nonhuman
periodontitis
tea
zone of inhibition
LA - English
PY - 2022
SN - 1773-2247
ST - Thermoreversible gel of green tea extract: Formulation and evaluation for the
management of periodontitis
TI - Thermoreversible gel of green tea extract: Formulation and evaluation for the
management of periodontitis
VL - 76
ID - 13176
ER -
TY - JOUR
AB - Periodontitis is an inflammatory disease characterized by tooth loss and
alveolar bone resorption. Bacteria are the original cause of periodontitis, and
excess reactive oxygen species (ROS) encourage and intensify inflammation. In this
study, a mussel-inspired and MnO(2) NPs-reinforced adhesive hydrogel capable of
alleviating periodontitis with improved antibacterial and antioxidant abilities was
developed. The hydrogel was created by combining polyvinyl alcohol (PVA), 3,4-
dihydroxy-d-phenylalanine (DOPA), and MnO(2) nanoparticles (NPs) (named PDMO
hydrogel). The hydrogel was demonstrated to be able to scavenge various free
radicals (including total ROS─O(2)(•-) and OH(•)) and relieve the hypoxia in an
inflammatory microenvironment by scavenging excess ROS and generating O(2) due to
its superoxide dismutase (SOD)/catalase (CAT)-like activity. Besides, under 808 nm
near-infrared (NIR) light, the photothermal performance of the PDMO hydrogel
displayed favorable antibacterial and antibiofilm effects toward Escherichia coli,
Staphylococcus aureus, and Porphyromonas gingivalis (up to nearly 100%
antibacterial rate). Furthermore, the PDMO hydrogel exhibited favorable therapeutic
efficacy in alleviating gingivitis in Sprague-Dawley rats, even comparable to or
better than the commercial PERIO. In addition, in the periodontitis models, the
PDMO2 group showed the height of the residual alveolar bone and the smallest shadow
area of low density among other groups, indicating the positive role of the PDMO2
hydrogel in bone regeneration. Finally, the biosafety of the PDMO hydrogel was
comprehensively investigated, and the hydrogel was demonstrated to have good
biocompatibility. Therefore, the developed PDMO hydrogel provided an effective
solution to resolve biofilm recolonization and oxidative stress in periodontitis
and could be a superior candidate for local drug delivery system in the clinical
management of periodontitis with great potential for future clinical translation.
AN - rayyan-563560800
AU - Hu, S.
AU - Wang, L.
AU - Li, J.
AU - Li, D.
AU - Zeng, H.
AU - Chen, T.
AU - Li, L.
AU - Xiang, X.
DO - 10.1021/acsbiomaterials.3c00454
J2 - ACS Biomater Sci Eng
LA - eng
N1 - Stomatological Hospital of Chongqing Medical University, Chongqing Key
Laboratory of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key
Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing Medical
University, Chongqing 401147, P. R. China.; Stomatological Hospital of Chongqing
Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical
Sciences, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of
Higher Education, Chongqing Medical University, Chongqing 401147, P. R. China.;
Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory
of Oral Diseases and Biomedical Sciences, Chongqing Municipal Key Laboratory of
Oral Biomedical Engineering of Higher Education, Chongqing Medical University,
Chongqing 401147, P. R. China.; Stomatological Hospital of Chongqing Medical
University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences,
Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher
Education, Chongqing Medical University, Chongqing 401147, P. R. China.;
Education, Chongqing Medical University, Chongqing 401147, P. R. China.;
Education, Chongqing Medical University, Chongqing 401147, P. R. China.
PY - 2023
ST - Catechol-Modified and MnO(2)-Nanozyme-Reinforced Hydrogel with Improved
Antioxidant and Antibacterial Capacity for Periodontitis Treatment
T2 - ACS biomaterials science & engineering
TI - Catechol-Modified and MnO(2)-Nanozyme-Reinforced Hydrogel with Improved
Y2 - 8 y3 - 29
ID - 14174
ER -
TY - JOUR
AB - Periodontitis is an inflammatory disease characterized by tooth loss and
alveolar bone resorption. Bacteria are the original cause of periodontitis, and
excess reactive oxygen species (ROS) encourage and intensify inflammation. In this
study, a mussel-inspired and MnO2 NPs-reinforced adhesive hydrogel capable of
alleviating periodontitis with improved antibacterial and antioxidant abilities was
developed. The hydrogel was created by combining polyvinyl alcohol (PVA), 3,4-
dihydroxy-d-phenylalanine (DOPA), and MnO2 nanoparticles (NPs) (named PDMO
hydrogel). The hydrogel was demonstrated to be able to scavenge various free
radicals (including total ROS─O2•- and OH•) and relieve the hypoxia in an
inflammatory microenvironment by scavenging excess ROS and generating O2 due to its
superoxide dismutase (SOD)/catalase (CAT)-like activity. Besides, under 808 nm
near-infrared (NIR) light, the photothermal performance of the PDMO hydrogel
displayed favorable antibacterial and antibiofilm effects toward Escherichia coli,
Staphylococcus aureus, and Porphyromonas gingivalis (up to nearly 100%
antibacterial rate). Furthermore, the PDMO hydrogel exhibited favorable therapeutic
efficacy in alleviating gingivitis in Sprague-Dawley rats, even comparable to or
better than the commercial PERIO. In addition, in the periodontitis models, the
PDMO2 group showed the height of the residual alveolar bone and the smallest shadow
area of low density among other groups, indicating the positive role of the PDMO2
hydrogel in bone regeneration. Finally, the biosafety of the PDMO hydrogel was
comprehensively investigated, and the hydrogel was demonstrated to have good
biocompatibility. Therefore, the developed PDMO hydrogel provided an effective
solution to resolve biofilm recolonization and oxidative stress in periodontitis
and could be a superior candidate for local drug delivery system in the clinical
management of periodontitis with great potential for future clinical translation.
AN - rayyan-563559684
AU - Hu, S.
AU - Wang, L.
AU - Li, J.
AU - Li, D.
AU - Zeng, H.
AU - Chen, T.
AU - Li, L.
AU - Xiang, X.
DO - 10.1021/acsbiomaterials.3c00454
KW - alveolar bone
animal experiment
animal model
article
biocompatibility
biofilm
biosafety
bone regeneration
controlled study
enzyme activity
Escherichia coli
gingivitis
hypoxia
infrared radiation
male
microenvironment
mussel
nonhuman
oxidative stress
periodontitis
rat
Sprague Dawley rat
surgery
adhesive agent
antiinfective agent
antioxidant
catalase
catechol
DOPA
endogenous compound
free radical
hydrogel
manganese dioxide
nanoparticle
oxygen
polyvinyl alcohol
LA - English
PY - 2023
SN - 2373-9878
ST - Catechol-Modified and MnO2-Nanozyme-Reinforced Hydrogel with Improved
T2 - ACS Biomater Sci Eng
TI - Catechol-Modified and MnO2-Nanozyme-Reinforced Hydrogel with Improved
ID - 13058
ER -
TY - JOUR
AB - Periodontitis is a common chronic inflammatory disease caused by plaque that
leads to alveolar bone resorption and tooth loss. Inflammation control and
achieving better tissue repair are the key to periodontitis treatment. In this
study, human β-Defensin 1 short motif Pep-B with inflammation inhibition and
differentiation regulation properties, is firstly used in the treatment of
periodontitis, and an injectable photopolymerizable Pep-B/chitosan methacryloyl
composite hydrogel (CMSA/Pep-B) is constructed. We confirm that Pep-B improves
inflammation, and restores osteogenic behavior and function of injured stem cells.
CMSA/Pep-B has good injectability, fluidity and photopolymerizability, and can
sustainably release Pep-B to maintain drug concentration in periodontal pockets.
Furthermore, animal experiments showed that CMSA/Pep-B significantly ameliorated
the inflammation of the periodontium and reduced the alveolar bone loss by
decreasing inflammatory infiltration, osteoclast formation and collagen
destruction. In conclusion, CMSA/Pep-B is envisaged to be a novel bioactive
material or therapeutic drug for treating periodontitis.
AN - rayyan-563559680
AU - Hu, Z.
AU - Zhou, Y.
AU - Wu, H.
AU - Hong, G.
AU - Chen, M.
AU - Jin, W.
AU - Lu, W.
AU - Zuo, M.
AU - Xie, Z.
AU - Shi, J.
DO - 10.1016/j.ijbiomac.2023.126060
KW - alveolar bone loss
article
controlled study
destruction
human
human cell
inflammation
osteoclastogenesis
periodontal pocket
periodontitis
periodontium
polymerization
stem cell
beta defensin 1
collagen
endogenous compound
hydrogel
LA - English
PY - 2023
SN - ["1879-0003", "0141-8130"]
ST - An injectable photopolymerizable chitosan hydrogel doped anti-inflammatory
peptide for long-lasting periodontal pocket delivery and periodontitis therapy
TI - An injectable photopolymerizable chitosan hydrogel doped anti-inflammatory
peptide for long-lasting periodontal pocket delivery and periodontitis therapy
VL - 252
ID - 13054
ER -
TY - JOUR
AB - Background/purpose: A challenge that arises with periodontal regeneration
sur-gery has been associated with the future development of periodontal
regeneration membrane to prevent gingiva and fibroblasts invade the wound and allow
alveolar bone successfully re-generated.Materials and methods: Chitosan (CS) has
the advantages of non-toxicity, biodegradation, biocompatibility, and has been
widely used in wound dressings. A flexible film was made using polyvinyl alcohol
(PVA) blending CS based thermosensitive hydrogel.Results: The proposed 2% PVA/CS
hydrogel has the highest swelling ratio about 720% after 60 min incubation and
keeps its area after 10 min incubation for surgery suture. The elastic modulus of
0%, 1%, 2%, and 4% PVA/CS hydrogel were 7.75 +/- 1.96, 0.91 +/- 0.16, 0.75 +/-
0.21, and 0.37 +/- 0.06 MPa, respectively. The maximum strain of 2% PVA/CS hydrogel
was 101.00 +/- 28.03 (%). After 8 weeks biodegradation, the remain weight of 2%
PVA/CS hydrogel was 71.36 +/- 0.79 (%).Conclusion: In vitro cytotoxicity tests were
performed and demonstrated PVA/CS hydrogel significantly improving cell
proliferation. This study realized a promising flexible film for peri-odontal
regeneration membrane that can prevent the rapid growth of fibroblasts to invade
the wound and be used for periodontal regeneration surgery.
AN - rayyan-563562267
AU - Huang, C. L.
AU - Huang, H. Y.
AU - Lu, Y. C.
AU - Cheng, C. J.
AU - Lee, T. M.
DO - 10.1016/j.jds.2023.01.007
IS - 2
PY - 2023
SN - ["1991-7902", "2213-8862"]
SP - 822-832
ST - Development of a flexible film made of polyvinyl alcohol with chitosan based
thermosensitive hydrogel
T2 - JOURNAL OF DENTAL SCIENCES
TI - Development of a flexible film made of polyvinyl alcohol with chitosan based
thermosensitive hydrogel
VL - 18
Y2 - 4
ID - 15641
ER -
TY - JOUR
AB - Human saliva performs a wide variety of biological functions that are
critical for the maintenance of the oral health. Various functions include
Lubrication, buffering, antimicrobial protection, and the maintenance of mucosal.
integrity. In addition, whole saliva may be analysed for the diagnosis of human
systemic diseases, since it can be readily collected and contains identifiable
serum constituents. By using proteomic approach, we have established a reference
proteome map of human whole sativa allowing for the resolution of greater than 200
protein spots in a single two-dimensional polyacrylamide get. Fifty-four protein
spots, comprised of 26 different proteins, were identifies using N-terminal.
sequencing, mass spectrometry, and/or computer matching with protein database. Ten
proteins, whose levels were significantly different when bleeding had occurred in
the oral cavity, were discussed in this study. These 10 proteins include alpha-1-
antrypsin, apolipoprotein A-I, cystatin A, SA, SAIII, and SN, enolase I, hemoglobin
beta-chain, thioredoxin peroxiredoxin B, as well as a protactin-inducible protein.
The proteomic approach identifies candidates from human whole saliva that may prove
to be of diagnostic and therapeutic significance. (C) 2004 Elsevier Ltd. ALL rights
reserved.
AN - rayyan-563562604
AU - Huang, C. M.
DO - 10.1016/j.archoralbio.2004.06.003
IS - 12
PY - 2004
SN - ["0003-9969", "1879-1506"]
SP - 951-962
ST - Comparative proteomic analysis of human whole saliva
T2 - ARCHIVES OF ORAL BIOLOGY
TI - Comparative proteomic analysis of human whole saliva
VL - 49
Y2 - 12
ID - 15978
ER -
TY - JOUR
AB - Introduction: Calcium silicate (CS) based materials play an important role in
the development of endodontic materials that induce bone/cementum tissue
regeneration and inhibit bacterial viability. The aim of this study was to prepare
novel mesoporous CS (MesoCS) nano particles that have osteogenic, drug delivery,
and antibacterial characteristics for endodontic materials and also have an
excellent ability to develop apatite mineralization. Methods: The MesoCS
nanoparticles were prepared using sol-gel methods. In addition, the mesoporous
structure, specific surface area, pore volume, and morphology of the MesoCS
nanoparticles were analyzed. The apatite mineralization ability, in vitro
odontogenic differentiation, drug delivery, and antibacterial properties of the
MesoCS nanoparticles were further investigated. Results: The results indicate that
the 200-nm sized MesoCS nanoparticles synthesized using a facile template method
exhibited a high specific surface area and pore volume with internal mesopores
(average pore size = 3.05 nm). Furthermore, the MesoCS nanoparticles can be used as
drug carriers to maintain sustained release of gentamicin and fibroblast growth
factor-2 (FGF-2). The MesoCS-loaded FGF-2 might stimulate more odontogenic-related
protein than CS because of the FGF-2 release. Conclusions: Based on this work, it
can be inferred that MesoCS nanoparticles are potentially useful endodontic
materials for biocompatible and osteogenic dental pulp tissue regenerative
materials.
AN - rayyan-563562612
AU - Huang, C. Y.
AU - Huang, T. H.
AU - Kao, C. T.
AU - Wu, Y. H.
AU - Chen, W. C.
AU - Shie, M. Y.
DO - 10.1016/j.joen.2016.09.012
IS - 1
PY - 2017
SN - ["0099-2399", "1878-3554"]
SP - 69-76
ST - Mesoporous Calcium Silicate Nanoparticles with Drug Delivery and
Odontogenesis Properties
TI - Mesoporous Calcium Silicate Nanoparticles with Drug Delivery and
Odontogenesis Properties
VL - 43
Y2 - 1
ID - 15986
ER -
TY - JOUR
AB - BACKGROUND: Previous studies showed that immunomodulatory peptide DP7 has
good antibacterial activity and immunomodulatory activity in vitro. OBJECTIVE: To
investigate the therapeutic effect of a new type of immunoregulatory peptide DP7
temperature-sensitive gel on periodontitis in rats. METHODS: The periodontitis
model of right maxillary first molar was established in 8-week-old SD rats, and the
48 successfully modeled rats were divided into 6 groups. Except for the natural
healing group without treatment, minocycline hydrochloride was injected into
periodontal pocket of positive control group. The periodontal pocket of the rest of
the four groups were injected with regulatory peptide DP7 concentration 0% (blank
gel), 0.1%, 0.3%, 1% temperature-sensitive gel, once a week for 4 weeks. Four weeks
later, the periodontal probing depth and the distance between cementum enamel
boundary and alveolar crest were examined; and histological and immunohistochemical
staining of the right maxilla was performed. RESULTS AND CONCLUSION: (1) The
probing depth and the distance between cementum enamel boundary and alveolar crest
in 1% and 0.3% DP7 gel treatment groups were lower than those in positive control
group (P <0.05). (2) Hematoxylin-eosin staining showed that the gingival tissue of
0.1%, 0.3%, 1% DP7 gel groups and positive control group was more complete, and the
epithelial pedicle process returned to normal, with the orderly array of
fibroblasts and new capillaries, and no obvious osteoclasts were observed. The
blank gel treatment group and the natural healing group showed the pathological
manifestations of periodontitis. (3) Masson staining showed that a large number of
new fibroblasts were orderly arranged in the 0.1%, 0.3%, and 1% DP7 gel groups and
the positive control group, and bulging collagen hyperplasia and new capillaries
were visible. Osteoid or new bone formation was even observed in the 1% and 0.3%
DP7 gel groups. However, the blank gel group and the natural healing group had no
obvious collagen fiber proliferation and osteoid formation. (4) Immunohistochemical
staining showed that the expression levels of tumor necrosis factor-α and
interleukin-1β in 0.3% and 1% DP7 gel groups were not significantly different from
those in the positive control group (P > 0.05). The expression levels of
interleukin-10, bone morphogenetic protein-2 and osteoblast specific transcription
factor 2 in 0.3% and 1% DP7 gel groups were higher than those in the positive
control group (P=0.000). The expression levels of interleukin-10, bone
morphogenetic protein-2 and osteoblast specific transcription factor 2 in 0.3% DP7
gel group were higher than those in the 1% DP7 gel group (P < 0.05). (5) The
results showed that 0.3% and 1% immunoregulatory peptide DP7 gel had favorable
therapeutic effect on periodontitis, and 0.3% immunoregulatory peptide DP7 gel had
the best therapeutic effect.
AN - rayyan-563559812
AU - Huang, J.
AU - Ren, J.
AU - Peng, P.
AU - Mu, Y.
DO - 10.12307/2022.279
IS - 22
collagen
eosin
gel
hematoxylin
interleukin 10
interleukin 1beta
minocycline
alveolar crest
animal experiment
animal model
animal tissue
article
cell proliferation
collagen fiber
controlled study
enamel
fibroblast
gingival tissue
healing
histology
hyperplasia
immunotherapy
maxilla
nonhuman
ossification
osteoclast
osteoid
periodontal pocket
periodontitis
rat
staining
tooth cementum
LA - Chinese
PY - 2022
SN - 2095-4344
SP - 3514-3520
ST - Treatment of periodontitis in rats with a novel temperature-sensitive gel
with immunomodulatory peptide
TI - Treatment of periodontitis in rats with a novel temperature-sensitive gel
with immunomodulatory peptide
VL - 26
ID - 13186
ER -
TY - JOUR
AB - In this study we aimed to develop novel ZnO-NP/chitosan/11-glycerophosphate
(ZnO-NP/CS/11-GP) antibacterial hydrogels for biomedical applications. According to
the mass fraction ratio of ZnO-NPs to chitosan, mixtures of 1, 3, and 5%
ZnO-NPs/CS/11-GP were prepared. Using the test-tube inversion method, scanning
electron microscopy and Fourier-transform infrared spectroscopy, the influence of
ZnO-NPs on gelation time, chemical composition, and cross-sectional microstructures
were evaluated. Adding ZnO-NPs significantly improved the hydrogel's antibacterial
activity as determined by bacteriostatic zone and colony counting. The hydrogel's
bacteriostatic mechanism was investigated using live/dead fluorescent staining and
scanning electron microscopy. In addition, crystal violet staining and MTT assay
demonstrated that ZnO-NPs/CS/11-GP exhibited good antibacterial activity in
inhibiting the formation of biofilms and eradicating existing biofilms. CCK-8 and
live/dead cell staining methods revealed that the cell viability of gingival
fibroblasts (L929) cocultured with hydrogel in each group was above 90% after 24,
48, and 72 h. These results suggest that ZnO-NPs improve the temperature
sensitivity and bacteriostatic performance of chitosan/11glycerophosphate (CS/11-
GP), which could be injected into the periodontal pocket in solution form and
quickly transformed into hydrogel adhesion on the gingiva, allowing for a
straightforward and convenient procedure. In conclusion, ZnO-NP/CS/11-GP
thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for
clinical prevention and treatment of peri-implant inflammation.
AN - rayyan-563562273
AU - Huang, P. P.
AU - Su, W.
AU - Han, R.
AU - Lin, H.
AU - Yang, J.
AU - Xu, L. B.
AU - Ma, L.
DO - 10.4014/jmb.2111.11024
IS - 4
PY - 2022
SN - ["1017-7825", "1738-8872"]
SP - 522-530
ST - Physicochemical, Antibacterial Properties, and Compatibility of
ZnO-NP/Chitosan/11-Glycerophosphate Composite Hydrogels
T2 - JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
TI - Physicochemical, Antibacterial Properties, and Compatibility of
ZnO-NP/Chitosan/11-Glycerophosphate Composite Hydrogels
VL - 32
Y2 - 4
ID - 15647
ER -
TY - JOUR
AB - In this study we aimed to develop novel ZnO-NP/chitosan/β-glycerophosphate
(ZnO-NP/CS/β-GP) antibacterial hydrogels for biomedical applications. According to
ZnO-NPs/CS/β-GP were prepared. Using the test-tube inversion method, scanning
demonstrated that ZnO-NPs/CS/β-GP exhibited good antibacterial activity in
sensitivity and bacteriostatic performance of chitosan/βglycerophosphate (CS/β-GP),
which could be injected into the periodontal pocket in solution form and quickly
transformed into hydrogel adhesion on the gingiva, allowing for a straightforward
and convenient procedure. In conclusion, ZnO-NP/CS/β-GP thermosensitive hydrogels
could be expected to be utilized as adjuvant drugs for clinical prevention and
treatment of peri-implant inflammation.
AN - rayyan-563559865
AU - Huang, P.
AU - Su, W.
AU - Han, R.
AU - Lin, H.
AU - Yang, J.
AU - Xu, L.
AU - Ma, L.
DO - 10.4014/jmb.2111.11024
IS - 4
KW - bath
cell viability assay kit
culture medium
fluorescence microscope
forceps
H 7650
microplate reader
microwell plate
nutrient agar medium
pH electrode
spectrometer
test tube
transmission electron microscope
acetic acid
chitosan
hydrogel
platinum
animal cell
animal experiment
animal model
antagonistic effect
article
bacterial strain
biofilm
cell viability
colony forming unit
confocal microscopy
cytotoxicity
fluorescence
gelation
incubation time
mouse
MTT assay
nonhuman
particle size
periodontal pocket
physical chemistry
sputter deposition
ultrasound
zone of inhibition
LA - English
PY - 2022
SN - ["1738-8872", "1017-7825"]
SP - 522-530
ZnO-NP/Chitosan/ β-Glycerophosphate Composite Hydrogels
T2 - J. Microbiol. Biotechnol.
ZnO-NP/Chitosan/ β-Glycerophosphate Composite Hydrogels
VL - 32
ID - 13239
ER -
TY - JOUR
AB - In this study we aimed to develop novel ZnO-NP/chitosan/β-glycerophosphate
(ZnO-NP/CS/β-GP) antibacterial hydrogels for biomedical applications. According to
ZnO-NPs/CS/β-GP were prepared. Using the test-tube inversion method, scanning
demonstrated that ZnO-NPs/CS/β-GP exhibited good antibacterial activity in
sensitivity and bacteriostatic performance of chitosan/β-glycerophosphate (CS/β-
GP), which could be injected into the periodontal pocket in solution form and
quickly transformed into hydrogel adhesion on the gingiva, allowing for a
straightforward and convenient procedure. In conclusion, ZnO-NP/CS/β-GP
thermosensitive hydrogels could be expected to be utilized as adjuvant drugs for
clinical prevention and treatment of peri-implant inflammation.
AN - rayyan-563560828
AU - Huang, P.
AU - Su, W.
AU - Han, R.
AU - Lin, H.
AU - Yang, J.
AU - Xu, L.
AU - Ma, L.
DO - 10.4014/jmb.2111.11024
IS - 4
J2 - J Microbiol Biotechnol
KW - Anti-Bacterial Agents/chemistry/pharmacology
*Chitosan/chemistry/pharmacology
Cross-Sectional Studies
Glycerophosphates
Hydrogels/chemistry/pharmacology
*Zinc Oxide/pharmacology
LA - eng
N1 - The Affiliated Hospital of Qingdao University, Qingdao 266003, P.R. China.;
School of Stomatology of Qingdao University, Qingdao 266003, P.R. China.; School of
Stomatology of Qingdao University, Qingdao 266003, P.R. China.; The Affiliated
Hospital of Qingdao University, Qingdao 266003, P.R. China.; School of Stomatology
of Qingdao University, Qingdao 266003, P.R. China.; School of Stomatology of
Qingdao University, Qingdao 266003, P.R. China.; School of Stomatology of Qingdao
University, Qingdao 266003, P.R. China.; School of Stomatology of Qingdao
University, Qingdao 266003, P.R. China.; The Affiliated Hospital of Qingdao
University, Qingdao 266003, P.R. China.; School of Stomatology of Qingdao
University, Qingdao 266003, P.R. China.
PY - 2022
SP - 522-530
ZnO-NP/Chitosan/β-Glycerophosphate Composite Hydrogels
T2 - Journal of microbiology and biotechnology
ZnO-NP/Chitosan/β-Glycerophosphate Composite Hydrogels
VL - 32
Y2 - 4 y3 - 28
ID - 14202
ER -
TY - JOUR
AB - The aim of this study was to evaluate the properties of the sustained release
and antibacterial activity of the ornidazole-drug-loaded membranes using
poly[(ethylene glycol)-caprolactone-lactide] (PCLA2575) as membrane material.
Ornidazole-loaded membranes were prepared by solvent casting method with the
proportion of 5wt%, 8wt%, and 10wt%, respectively. In vitro drug release properties
were determined by ultraviolet spectrophotometric method. The antibacterial
activities against Streptococcus mutans and Fusobacterium nucleatumin vitro were
observed on solid culture medium. The membrane had the high drug loadings and slow-
release performance. Drug release time was shortened with the increase in the
content of ornidazole, but all of them can achieve more than 7days. The membrane
had strong inhibitory effect on both S. mutans and F. nucleatum. As drug content
increased, the antibacterial activities also increased. The membrane had better
inhibitory effect on F. nucleatum than S. mutans. Therefore, the ornidazole drug-
loaded membrane is expected to be used for the treatment of periodontal disease
because of the obvious effect of periodontal pathogens inhibition and good
sustained-release performance.
AN - rayyan-563562427
AU - Huang, Z. M.
AU - Wang, S. C.
AU - Wang, N. T.
AU - Ma, X. F.
AU - Karki, J.
AU - Han, Z. H.
AU - Lang, M. D.
AU - Zhu, B. S.
AU - Zhang, X. Y.
DO - 10.1177/0883911517693636
IS - 6
PY - 2017
SN - ["0883-9115", "1530-8030"]
SP - 615-627
ST - Preparation and evaluation of PCLA2575 membranes loaded ornidazole in vitro
T2 - JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
TI - Preparation and evaluation of PCLA2575 membranes loaded ornidazole in vitro
VL - 32
Y2 - 11
ID - 15801
ER -
TY - JOUR
AB - Octenidine dihydrochloride (octenidine) was introduced for skin, mucous
membrane and wound antisepsis more than 20 years ago. Until now, a wealth of
knowledge has been gained, including in vitro and animal studies on efficacy,
tolerance, safety and clinical experience both from case reports and prospective
controlled trials. Nowadays, octenidine is an established antiseptic in a large
field of applications and represents an alternative to older substances such as
chlorhexidine, polyvidone-iodine or triclosan. The review is based on the current
literature and unpublished original data as well. © 2010 S. Karger AG.
AN - rayyan-563560638
AU - Hübner, N. O.
AU - Siebert, J.
AU - Kramer, A.
DO - 10.1159/000314699
IS - 5
KW - 2 phenoxyethanol
2 propanol
alcohol
alexidine
chlorhexidine
gentamicin
glucocorticoid
hexetidine
imipenem
metronidazole
octenidine
piperacillin plus tazobactam
placebo
povidone iodine
propanol
mupirocin
shampoo
soap
triclosan
acne
antisepsis
antiviral activity
vaginitis
biofilm
carcinogenicity
clinical trial
cytotoxicity
drug absorption
drug efficacy
drug excretion
drug metabolism
drug potentiation
drug resistance
drug safety
drug tolerance
ecotoxicology
gel
genotoxicity
human
LD50
methicillin resistant Staphylococcus aureus infection
mucosa
nail infection
nonhuman
periodontal disease
physical chemistry
plankton
priority journal
Pseudomonas infection
review
single drug dose
skin absorption
skin penetration
skin toxicity
tooth plaque
treatment contraindication
vagina candidiasis
wound
wound healing
LA - English
PY - 2010
SN - 1660-5527
SP - 244-258
ST - Octenidine dihydrochloride, a modern antiseptic for skin, mucous membranes
and wounds
T2 - Skin Pharmacol. Physiol.
TI - Octenidine dihydrochloride, a modern antiseptic for skin, mucous membranes
and wounds
VL - 23
ID - 14012
ER -
TY - JOUR
AB - Bacteroides forsythus strains recovered from cat and dog bite wound
infections in humans (n = 3), monkey oral strains (n = 3), and the human oral ATCC
43037 type strain were characterized by using phenotypic characteristics, enzymatic
tests, whole cell fatty acid analysis, sodium dodecyl sulfate-polyacrylamide gel
electrophoresis (SDS-PAGE) analysis, PCR fingerprinting, and 16S rDNA (genes coding
for rRNA) sequencing. All three bite wound isolates grew on brucella agar
supplemented with 5% sheep blood, vitamin K1, and hemin. These strains, unlike the
ATCC strain and previously described monkey oral and human clinical strains, did
not require N- acetylmuramic acid supplementation for growth as pure cultures.
However, their phenotypic characteristics, except for catalase production, were
similar to those of previously identified strains. PCR fingerprinting analysis
showed differences in band patterns from the ATCC strain. Also, SDS- PAGE and whole
cell fatty acid analysis indicated that the dog and cat bite wound strains were
similar but not identical to the human B. forsythus ATCC 43037 type strain and the
monkey oral strains. The rDNA sequence analysis indicated that the three bite wound
isolates had 99.93% homology with each other and 98.9 and 99.22% homology with the
human ATCC 43037 and monkey oral strains, respectively. These results suggest that
there are host-specific variations within each group.
AN - rayyan-563561016
AU - Hudspeth, M. K.
AU - Hunt Gerardo, S.
AU - Maiden, M. F. J.
AU - Citron, D. M.
AU - Goldstein, E. J. C.
DO - 10.1128/jcm.37.6.2003-2006.1999
IS - 6
colistin
fatty acid
kanamycin
ribosome DNA
RNA 16S
vancomycin
article
Bacteroides
cat
dog bite
Haplorhini
nonhuman
nucleotide sequence
priority journal
strain difference
wound infection
LA - English
PY - 1999
SN - 0095-1137
SP - 2003-2006
ST - Characterization of Bacteroides forsythus strains from cat and dog bite
wounds in humans and comparison with monkey and human oral strains
T2 - J. Clin. Microbiol.
TI - Characterization of Bacteroides forsythus strains from cat and dog bite
wounds in humans and comparison with monkey and human oral strains
VL - 37
ID - 14390
ER -
TY - JOUR
AN - rayyan-563561763
AU - Hugar, S. S.
AU - Patil, S.
AU - Metgud, R.
AU - Nanjwade, B.
AU - Hugar, S. M.
DO - 10.4103/0976-9668.184701
IS - 2
PY - 2016
SP - 149-154
ST - Influence of application of chlorhexidine gel and curcumin gel as an adjunct
to scaling and root planing: A interventional study
T2 - Journal of Natural Science, Biology and Medicine
TI - Influence of application of chlorhexidine gel and curcumin gel as an adjunct
to scaling and root planing: A interventional study
84978906925&doi=10.4103%2f0976-
9668.184701&partnerID=40&md5=8df7b6fe5736b2b9fa0358e9dc536ee6
VL - 7
ID - 15137
ER -
TY - JOUR
AB - BACKGROUND: Proper oral hygiene and absence of periodontal inflammation is
pre-requisite for orthodontic treatment. Chlorhexidine (CHX) is an established oral
antiseptic used in the treatment of periodontal disease, but its role in
orthodontic therapy is unclear. OBJECTIVES: To assess the efficacy of adjunct use
of CHX-containing products in maintaining gingival health among orthodontic
patients with fixed appliances. SEARCH METHODS: Five databases were searched
without limitations up to August 2021. SELECTION CRITERIA: Randomized clinical
trials (RCTs) assessing Gingival Index (GI) (primary outcome), Plaque Index (PI),
Bleeding Index (BI), or Pocket Probing Depth (PPD). DATA COLLECTION AND ANALYSIS:
Study selection, data extraction, and risk of bias assessment were done
independently in duplicate. Random-effects meta-analyses of mean differences (MDs)
or standardized mean differences (SMDs) with their 95% confidence intervals (CIs)
were conducted, followed by sensitivity and Grades of Recommendations, Assessment,
Development and Evaluation analysis. RESULTS: Twenty RCTs (1001 patients) were
included assessing CHX-containing mouthwashes (n = 11), toothpastes (n = 2), gels
(n = 3), or varnishes (n = 4) compared to placebo/control (n = 19) or sodium
fluoride-products (n = 4). In the short-term, CHX-containing mouthwash was
associated with lower GI (n = 9; MD = -0.68; 95% CI = -0.97 to -0.38; P < 0.001;
high quality), lower PI (n = 9; MD = -0.65; 95% CI = -0.86 to -0.43; P < 0.001;
high quality), lower BI (n = 2; SMD = -1.61; 95% CI = -2.99 to -0.22; P = 0.02; low
quality), and lower PPD (n = 2; MD = -0.60 mm; 95% CI = -1.06 to -0.14 mm; P =
0.01; low quality). No considerable benefits were found from the use of CHX-gel or
CHX-varnish in terms of GI, PI, or PPD (P > 0.05/low quality in all instances). Use
of a CHX-containing toothpaste was more effective in lowering PI (Heintze-index)
than adjunct use of fluoride-containing mouthwash (n = 2; MD = -5.24; 95% CI = -
10.46 to -0.02; P = 0.04), but not GI (P = 0.68) or BI (P = 0.27), while
sensitivity analyses indicated robustness. CONCLUSIONS: Adjunct use of CHX
mouthwash during fixed-appliance treatment is associated with improved gingival
inflammation, plaque control, and pocket depths, but caution is warranted and
recommendations about CHX use during orthodontic treatment of children/adults
should consider the heterogeneous patient response, cost-effectiveness, and
potential adverse effects. REGISTRATION: PROSPERO registration (CRD42021228759).
AN - rayyan-563559748
AU - Hussain, U.
AU - Alam, S.
AU - Rehman, K.
AU - Antonoglou, G. N.
AU - Papageorgiou, S. N.
DO - 10.1093/ejo/cjac044
IS - 1
KW - chlorhexidine
fluoride
mouth hygiene
toothpaste
adult
adverse event
child
human
inflammation
meta analysis
LA - English
PY - 2023
SN - 1460-2210
SP - 103-114
ST - Effects of chlorhexidine use on periodontal health during fixed appliance
orthodontic treatment: a systematic review and meta-analysis
T2 - Eur J Orthod
TI - Effects of chlorhexidine use on periodontal health during fixed appliance
orthodontic treatment: a systematic review and meta-analysis
VL - 45
ID - 13122
ER -
TY - JOUR
AB - Objective: To assess the antibacterial efficacy of chitosan nanoparticles
(CSNPs), calcium hydroxide (Ca(OH)(2)) and double antibiotic paste (DAP) against 3-
week-old Enterococcus faecalis biofilm. Materials and methods: Sixty extracted
mandibular premolars were standardised to a specimen length (14 mm), instrumented
and, after sterilisation, inoculated with E. faecalis and incubated for 3 weeks.
Biofilm formation was confirmed by scanning electron microscopy in four randomly
selected specimens. The remaining specimens (n = 56) were divided into four groups
(n = 14): Group 1, 20 mg/ml CSNPs in methylcellulose; Group 2, 35% Ca(OH)(2) in
methylcellulose; Group 3, 1 mg/ml DAP in methylcellulose; and Group 4,
methylcellulose gel (control group). Each group was further divided into two equal
subgroups (n = 7) and incubated for 7 or 14 days. After each test period, a sample
of the biofilm was collected from each specimen, plated, and the antimicrobial
efficacy assessed via colony forming units count (CFU/ml). Results: All the
antibacterial agents evaluated resulted in complete eradication of E. faecalis
after 14 days. However, Ca(OH)(2) was the only medicament that provided a
significant bacterial count reduction after 7 days (P < 0.05). No statistically
significant difference was found between Ca(OH)(2), CSNPs, and DAP (P >= 0.05).
Conclusions: A 14-day period of dressing with CSNPs, Ca(OH)(2), or DAP resulted in
effective antibacterial action on the 3-week-old E. faecalis biofilm.
AN - rayyan-563562510
AU - Hussein, M. M.
AU - Abdallah, A. M.
AU - Mokhless, N. A.
AU - Meheissen, M. A.
IS - 3
PY - 2019
SN - ["1753-2809", "1753-2817"]
SP - 255-263
ST - An ex vivo study to determine the antibacterial efficacy of chitosan
nanoparticles, calcium hydroxide and double antibiotic paste as intracanal
medicaments against Enterococcus faecalis biofilm
T2 - ENDO-ENDODONTIC PRACTICE TODAY
TI - An ex vivo study to determine the antibacterial efficacy of chitosan
nanoparticles, calcium hydroxide and double antibiotic paste as intracanal
medicaments against Enterococcus faecalis biofilm
VL - 13
ID - 15884
ER -
TY - JOUR
AB - ObjectiveThe aim of this study was to compare the proteome composition of
gingival crevicular fluid obtained from healthy periodontium, gingivitis and
chronic periodontitis affected sites. BackgroundOwing to its site-specific nature,
gingival crevicular fluid is ideal for studying biological processes that occur
during periodontal health and disease progression. However, few studies have been
conducted into the gingival crevicular fluid proteome due to the small volumes
obtained. MethodsFifteen males were chosen for each of three different groups,
healthy periodontium, gingivitis and chronic periodontitis. They were categorized
based on clinical measurements including probing depth, bleeding on probing, plaque
index, radiographic bone level, modified gingival index and smoking status.
Gingival crevicular fluid was collected from each patient, pooled into healthy,
gingivitis and chronic periodontitis groups and their proteome analyzed by gel
electrophoresis and liquid chromatography electrospray ionization ion trap tandem
mass spectrometry. ResultsOne hundred and twenty-one proteins in total were
identified, and two-thirds of these were identified in all three conditions. Forty-
two proteins were considered to have changed in abundance. Of note, cystatin B and
cystatin S decreased in abundance from health to gingivitis and further in chronic
periodontitis. Complement proteins demonstrated an increase from health to
gingivitis followed by a decrease in chronic periodontitis. Immunoglobulins,
keratin proteins, fibronectin, lactotransferrin precursor, 14-3-3 protein
zeta/delta, neutrophil defensin 3 and alpha-actinin exhibited fluctuations in
levels. ConclusionThe gingival crevicular fluid proteome in each clinical condition
was different and its analysis may assist us in understanding periodontal
pathogenesis.
AN - rayyan-563562271
AU - Huynh, A. H. S.
AU - Veith, P. D.
AU - McGregor, N. R.
AU - Adams, G. G.
AU - Chen, D.
AU - Ngo, L. H.
AU - Darby, I. B.
DO - 10.1111/jre.12244
IS - 5
PY - 2015
SN - ["0022-3484", "1600-0765"]
SP - 637-649
ST - Gingival crevicular fluid proteomes in health, gingivitis and chronic
periodontitis
TI - Gingival crevicular fluid proteomes in health, gingivitis and chronic
periodontitis
VL - 50
Y2 - 10
ID - 15645
ER -
TY - JOUR
AB - The aim of this study is to evaluate the effect of the subgingival
application of 0.8% hyaluronic acid (HA) gel as an adjunct to scaling and root
planing (SRP) in the treatment of chronic periodontitis. Twenty patients with
chronic periodontitis were recruited to participate in a study and divided to Group
1 (G1) treated with 8% hyaluronic acid gel as an adjunctive to scaling and root
planning (HARP) and Group 2 (G 2) treated with scaling and root planning only.
Plaque index (PL.I) Gingival index (G.I) and bleeding on probing (B.O.P) were
evaluated pretreatment (baseline) (1st visits), one week (2nd visits), and 4 weeks
(3rd visit) posttreatment. Subgingival plaque sample were taken for microbiologic
analysis at baseline and 4 weeks posttreatment. Intragroup comparison result
between visits for Group 1showed that there was highly significant different for
BOP, CFU, and no significant different for PLI and GI between 2nd and 3rd visit.
For G 2, there was highly significant different for GI and significant for PLI and
BOP, and non-significant different CFU, between 2nd and 3rd visit. Intergroup
comparison for clinical parameter and bacteriological result between visits Showed
that there was highly significant different in1st visit for PLI, BOP and CFU in 3
rd visit. It can be conclude that the local application of hyaluronic acid gel
(0.8%) in conjunction with scaling and root planning have a beneficial effect on
clinical periodontal parameter and may prevent recolonization of periodontal
pathogens in patients with chronic periodontitis.
AN - rayyan-563560084
AU - Ibraheem, L. M.
AU - Abdulhameed, B. S.
AU - Ali, W. M.
AU - Dhafer, A. M.
DO - 10.37506/ijphrd.v11i10.11174
IS - 10
adult
article
bleeding
clinical article
colony forming unit
comparative study
controlled study
drug effect
female
gingival index
human
male
plaque index
root planing
LA - English
PY - 2020
SN - ["0976-5506", "0976-0245"]
SP - 357-363
ST - The effect of hyaluronic acid as an adjunct after scaling and root planning
in the treatment of chronic periodontitis
TI - The effect of hyaluronic acid as an adjunct after scaling and root planning
in the treatment of chronic periodontitis
VL - 11
ID - 13458
ER -
TY - JOUR
AB - Background: Extensive in vitro and in vivo research has been conducted in the
previous decades to analyze the effectiveness of medicinal plants in the treatment
of periodontal diseases. Moringa oleifera is a highly potent medicinal plant that
has anti-inflammatory and immuno-modulatory properties. In our study, we aim to
design, formulate, and evaluate the antibacterial efficacy of M. oleifera extract
for local drug delivery (LDD) as periodontal treatment. Materials and Methods: This
study was an in vitro experimental model. M. oleifera extract was prepared using a
maceration process with powdered dried leaves of M. oleifera and 70% ethanol. The
minimum inhibitory concentration (MIC) of Moringa extract against Porphyromonas
gingivalis was assessed using the broth dilution method. The gel was prepared with
the obtained MIC of Moringa extract and a combination of polymers- Polyethylene
glycol 6000, Carbopol 940, and Chitosan. Further, the formulated gel was subjected
to in vitro characterization by thermodynamic stability tests, pH determination,
and syringeability test. Viscosity was determined using Brookfield DV-II +
Viscometer. Mucoadhesive strength was determined using a fabricated mucoadhesive
strength test apparatus. Results: M. oleifera leaves extract possesses a
bactericidal effect against P. gingivalis even at a low amounts of 25 μg/ml and so
is a potent botanical extract for the formulation of LDD agents for periodontal
diseases. The formulation shows adequate stability, good mucoadhesiveness, and
controlled drug release, on incorporating the herbal extract into the blank gel.
Conclusion: The M. oleifera leaves extract possesses a bactericidal effect against
P. gingivalis which has been suggested to be the keystone pathogen in the
etiopathogenesis of periodontitis. Hence, M. oleifera leaves extract can be used to
treat periodontal diseases as a LDD agent.
AN - rayyan-563559744
AU - Ida, M. J.
AU - Shetty, B.
AU - Khan, S. F.
AU - Yadalam, U.
AU - Nambiar, M.
DO - 10.4103/jisp.jisp_710_21
IS - 2
KW - viscometer
alcohol
carbopol 940
chitosan
Moringa oleifera extract
polymer
article
broth dilution
controlled study
drug formulation
in vitro study
Moringa oleifera
nonhuman
periodontal disease
periodontitis
pH measurement
plant leaf
viscosity
LA - English
PY - 2023
SN - ["0975-1580", "0972-124X"]
SP - 146-153
ST - Development and in vitro characterization of a mucoadhesive gel with Moringa
oleifera extract for periodontal drug delivery
TI - Development and in vitro characterization of a mucoadhesive gel with Moringa
oleifera extract for periodontal drug delivery
VL - 27
ID - 13118
ER -
TY - JOUR
AB - Certain serotypes of Actinobacillus actinomycetemcomitans seem to prefer
coexistence in vivo. The 16S rDNA PCR-denaturing gradient gel electrophoresis
(DGGE) was tested for its capability to distinguish coexisting A.
actinomycetemcomitans strains of different serotypes or genetic lineages and to
determine their proportions in vitro. The migration pattern of the PCR amplicon
from serotype c differed from those of the other serotypes. Contrary to the strains
of serotypes c, d, and e, strains of serotypes a, b, and f consistently
demonstrated intra-serotype migration patterns similar to each other. Since the
migration patterns differed between serotype c and b strains a strain of each was
used to determine their proportional representation in a strain mixture. The
strains were distinguishable from each other above the 5% PCR-DGGE detection level
(12.5 ng DNA/1.5 x 10(6) cells). DGGE provides a promising tool for in vitro
studies on the coexistence of different genetic lineages of A.
actinomycetemcomitans. (c) 2005 Elsevier B.V. All rights reserved.
AN - rayyan-563562523
AU - Ihalin, R.
AU - Asikainen, S.
DO - 10.1016/j.mimet.2005.08.016
IS - 3
PY - 2006
SN - ["0167-7012", "1872-8359"]
SP - 417-424
ST - 16S rDNA PCR-denaturing gradient gel electrophoresis in detennining
proportions of coexisting Actinobacillus actinomycetemcomitans strains
T2 - JOURNAL OF MICROBIOLOGICAL METHODS
TI - 16S rDNA PCR-denaturing gradient gel electrophoresis in detennining
proportions of coexisting Actinobacillus actinomycetemcomitans strains
VL - 65
Y2 - 6
ID - 15897
ER -
TY - JOUR
AB - Local delivery systems of antimicrobial agents for treatment of the
periodontal diseases received considerable attention during the past decade due to
the disadvantages of the systemic administration. An ideal formulation should
exhibit ease of delivery, a good retention at the application site, and a
controlled release of the drug. The application of bioadhesive gels provides a long
stay in the oral cavity, adequate drug penetration, high efficacy and
acceptability. In dentistry and oral medicine, various applications of chitosan,
which is a bioadhesive polymer have been proposed due to its favorable properties
such as biocompatibility and biodegradability. The aim of this study was to
determine the antimicrobial activity of chitosan formulations either in gel or film
form against a periodontal pathogen, Porphyromonas gingivalis. The viscosity,
bioadhesive properties and antimicrobial activity of chitosans at different
molecular weight and deacetylation degree were evaluated in the absence or presence
of chlorhexidine gluconate (Chx), incorporated into the formulations at 0.1 and
0.2% concentrations. The flow property of the gels were found to be suitable for
topical application on the oral mucosa and to syringe into the periodontal pocket.
Bioadhesion of the gels and films examined ex-vivo using fresh porcine buccal
mucosa showed that both the film and gel formulations exert bioadhesive properties
and was not affected by incorporation of Chx. Chitosan is shown to have an
antimicrobial activity against P. gingivalis and this was higher with high
molecular weight chitosan. The combination of chitosan with Chx showed a higher
when compared to that of Chx alone, which would provide Chx application at lower
concentrations thus avoiding its unwanted side effects. Chitosan films and gels
seem to be promising delivery systems for local therapy of periodontal diseases
with its bioadhesive property and antimicrobial activity. © 2002 Elsevier Science
B.V. All rights reserved.
AN - rayyan-563560911
AU - Ikinci, G.
AU - Şenel, S.
AU - Akincibay, H.
AU - Kaş, S.
AU - Erciş, S.
AU - Wilson, C. G.
AU - Hincal, A. A.
DO - 10.1016/S0378-5173(01)00974-7
IS - 1
KW - adhesive agent
chitosan
protasan
unclassified drug
adhesion
article
buccal mucosa
controlled study
deacetylation
film
gel
molecular weight
mouth cavity
nonhuman
periodontitis
priority journal
viscosity
LA - English
PY - 2002
SN - 0378-5173
SP - 121-127
ST - Effect of chitosan on a periodontal pathogen Porphyromonas gingivalis
T2 - Int. J. Pharm.
TI - Effect of chitosan on a periodontal pathogen Porphyromonas gingivalis
VL - 235
ID - 14285
ER -
TY - JOUR
acceptability. In dentistry and oral medicine, various applications of chitosan,
determine the antimicrobial activity of chitosan formulations either in gel or film
form against a periodontal pathogen, Porphyromonas gingivalis. The viscosity,
activity when compared to that of Chx alone, which would provide Chx application at
lower concentrations thus avoiding its unwanted side effects. Chitosan films and
gels seem to be promising delivery systems for local therapy of periodontal
diseases with its bioadhesive property and antimicrobial activity.
AN - rayyan-563561279
AU - Ikinci, G.
AU - Senel, S.
AU - Akincibay, H.
AU - Kaş, S.
AU - Erciş, S.
AU - Wilson, C. G.
AU - Hincal, A. A.
DO - 10.1016/s0378-5173(01)00974-7
IS - 1
J2 - Int J Pharm
KW - Anti-Bacterial Agents/*administration & dosage/chemistry
Bacterial Adhesion/drug effects
Bacteroidaceae Infections/drug therapy/*microbiology
Chitin/*administration & dosage/analogs & derivatives/chemistry
Chitosan
Chlorhexidine/administration & dosage/*analogs & derivatives/chemistry
Drug Delivery Systems/methods
Drug Evaluation, Preclinical/methods
Gels
Humans
Periodontal Diseases/drug therapy/*microbiology
Porphyromonas gingivalis/*drug effects/growth & development
Viscosity
LA - eng
N1 - Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe
University, 06100, Ankara, Turkey.
PY - 2002
SN - 0378-5173 (Print)
SP - 121-7
T2 - International journal of pharmaceutics
VL - 235
Y2 - 3 y3 - 20
ID - 14653
ER -
TY - JOUR
AN - rayyan-563562066
AU - Ikinci, G.
AU - Şenel, S.
AU - Akincibay, H.
AU - Kaş, S.
AU - Erciş, S.
AU - Wilson, C. G.
AU - Hincal, A. A.
DO - 10.1016/S0378-5173(01)00974-7
IS - 1
PY - 2002
SP - 121-127
T2 - International Journal of Pharmaceutics
0037139414&doi=10.1016%2fS0378-5173%2801%2900974-
7&partnerID=40&md5=2fbd10e5e8962fd1a94e0d02b2b2053b
VL - 235
ID - 15440
ER -
TY - JOUR
acceptability. In dentistry and oral medicine. various applications of chitosan,
determine the antimicrobial activity of chitosan formulations either in get or film
form against a periodontal pathogen, Porphyromonas gingalvalis. The viscosity,
activity when compared to that of Chx alone, which would provide Chx application at
lower concentrations thus avoiding its unwanted side effects. Chitosan films and
gels seem to be promising delivery systems for local therapy of periodontal
diseases with its bioadhesive property and antimicrobial activity. (C) 2002
Elsevier Science B.V. All rights reserved.
AN - rayyan-563562247
AU - Ikinci, G.
AU - Senel, S.
AU - Akincibay, H.
AU - Kas, S.
AU - Ercis, S.
AU - Wilson, C. G.
AU - Hincal, A. A.
DO - 10.1016/S0378-5173(01)00974-7
IS - 1
PY - 2002
SN - 0378-5173
SP - 121-127
VL - 235
Y2 - 3 y3 - 20
ID - 15621
ER -
TY - JOUR
AB - Background and objectives: this study aims to evaluate the clinical and
microbiological effects of a single subgingival administration of a locally
delivered antibiotic gel containing piperacillin plus tazobactam and compare it
with a slow-release doxycycline (14%) gel and a placebo gel, following subgingival
instrumentation (SI) in patients with severe periodontitis. Materials and methods:
sixty-four patients diagnosed with stage III-IV periodontitis were enrolled, were
randomly assigned into three groups, and were treated additionally with a single
subgingival administration of piperacillin plus tazobactam gel (group A);
doxycycline gel (group B); and placebo gel (group C). The primary outcome variable
was the change in mean probing pocket depth (PPD) 6 months after the intervention.
Secondary outcome variables were changes in mean full-mouth bleeding score (FMBS);
full-mouth plaque score (FMPS); overall bleeding index (BOP); pocket closure; and
clinical attachment level (CAL), along with changes in the numbers of five keystone
bacteria: Aggregatibacter actinomycetemcomitans (A.a.), Porphyromonas gingivalis
(P.g.), Prevotella intermedia (P.i.), Tannerella forsythia (T.f.), and Treponema
denticola (T.d.). Intergroup and intragroup differences were evaluated at 3 and 6
months. Results: at baseline, the three groups were comparable. An improvement in
clinical parameters such as PPD, CAL, and BOP between groups was observed at 3 and
6 months, but without statistical significance (p > 0.05). At 6 months, the
intragroup analysis showed a significant reduction in clinical parameters. Even
though the piperacillin plus tazobactam group showed slightly higher PPD reduction,
this was not statistically significant when compared to both control groups.
Conclusions: The groups had similar results, and subgingival instrumentation can be
executed without adjunctive antimicrobials, reducing the costs for the patient and
the working time/load of the professional.
AN - rayyan-563559749
AU - Ilyes, I.
AU - Rusu, D.
AU - Rădulescu, V.
AU - Vela, O.
AU - Boariu, M. I.
AU - Roman, A.
AU - Surlin, P.
AU - Kardaras, G.
AU - Boia, S.
AU - Chinnici, S.
AU - Jentsch, H. F. R.
AU - Stratul, S. I.
DO - 10.3390/medicina59020303
IS - 2
doxycycline
controlled study
human
microbiology
periodontal pocket
periodontitis
pharmacology
LA - English
PY - 2023
SN - 1648-9144
ST - A Placebo-Controlled Trial to Evaluate Two Locally Delivered Antibiotic Gels
(Piperacillin Plus Tazobactam vs. Doxycycline) in Stage III-IV Periodontitis
Patients
T2 - Medicina (Kaunas)
TI - A Placebo-Controlled Trial to Evaluate Two Locally Delivered Antibiotic Gels
Patients
VL - 59
ID - 13123
ER -
TY - JOUR
AB - Background and objectives: this study aims to evaluate the clinical and
microbiological effects of a single subgingival administration of a locally
delivered antibiotic gel containing piperacillin plus tazobactam and compare it
with a slow-release doxycycline (14%) gel and a placebo gel, following subgingival
instrumentation (SI) in patients with severe periodontitis. Materials and methods:
sixty-four patients diagnosed with stage III-IV periodontitis were enrolled, were
randomly assigned into three groups, and were treated additionally with a single
subgingival administration of piperacillin plus tazobactam gel (group A);
doxycycline gel (group B); and placebo gel (group C). The primary outcome variable
was the change in mean probing pocket depth (PPD) 6 months after the intervention.
Secondary outcome variables were changes in mean full-mouth bleeding score (FMBS);
full-mouth plaque score (FMPS); overall bleeding index (BOP); pocket closure; and
clinical attachment level (CAL), along with changes in the numbers of five keystone
bacteria: Aggregatibacter actinomycetemcomitans (A.a.), Porphyromonas gingivalis
(P.g.), Prevotella intermedia (P.i.), Tannerella forsythia (T.f.), and Treponema
denticola (T.d.). Intergroup and intragroup differences were evaluated at 3 and 6
months. Results: at baseline, the three groups were comparable. An improvement in
clinical parameters such as PPD, CAL, and BOP between groups was observed at 3 and
6 months, but without statistical significance (p > 0.05). At 6 months, the
intragroup analysis showed a significant reduction in clinical parameters. Even
though the piperacillin plus tazobactam group showed slightly higher PPD reduction,
this was not statistically significant when compared to both control groups.
Conclusions: The groups had similar results, and subgingival instrumentation can be
executed without adjunctive antimicrobials, reducing the costs for the patient and
the working time/load of the professional.
AN - rayyan-563562355
AU - Ilyes, I.
AU - Rusu, D.
AU - Radulescu, V.
AU - Vela, O.
AU - Boariu, M. I.
AU - Roman, A.
AU - Surlin, P.
AU - Kardaras, G.
AU - Boia, S.
AU - Chinnici, S.
AU - Stratul, S. I.
DO - 10.3390/medicina59020303
IS - 2
PY - 2023
SN - ["1010-660X", "1648-9144"]
Patients
T2 - MEDICINA-LITHUANIA
Patients
VL - 59
Y2 - 2
ID - 15729
ER -
TY - JOUR
AN - rayyan-563561558
AU - Ilyes, I.
AU - Rusu, D.
AU - Rădulescu, V.
AU - Vela, O.
AU - Boariu, M. I.
AU - Roman, A.
AU - Surlin, P.
AU - Kardaras, G.
AU - Boia, S.
AU - Chinnici, S.
AU - Stratul, S. I.
DO - 10.3390/medicina59020303
IS - 2
PY - 2023
(Piperacillin Plus Tazobactam vs. Doxycycline) in Stage III–IV Periodontitis
Patients
T2 - Medicina (Lithuania)
(Piperacillin Plus Tazobactam vs. Doxycycline) in Stage III–IV Periodontitis
Patients
85148878372&doi=10.3390%2fmedicina59020303&partnerID=40&md5=07be6fe26bb5139cac2e53a
6eb40a9b8
VL - 59
ID - 14932
ER -
TY - JOUR
AB - Porphyromonas gingivalis is a gram-negative rod associated with the
progression of human periodontal disease. Inflammatory cytokines are believed to be
the major pathological mediators in periodontal diseases. We therefore investigated
the productions of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-
8), and tumor necrosis factor-α (TNF-α in human gingival fibroblasts treated with
lipopolysaccharide, polysaccharide and outer-membrane proteins from P. gingivalis
ATCC 53977. Outer-membrane protein from P. gingivalis enhanced the production of
IL-6 and IL-8 from the cells of periodontium in vitro as well as lipopolysaccharide
did. The IL-8 production activity of polysaccharide from P. gingivalis was higher
than that of other cell-surface components. The levels of IL-6 and IL-8 released
from the P. gingivalis lipopolysaccharide-treated human gingival fibroblasts were
lower than those of the same cells treated with lipopolysaccharides from
Actinobacillus actinomycetemcomitans or Escherichia coli. Rabbit antisera against
either outer-membrane protein or lipopolysaccharide inhibited the IL-6 and IL-8
production derived from human gingival fibroblasts stimulated sonicated
supernatants from P. gingivalis. The present study suggests that, in addition to
lipopolysaccharide, outer-membrane protein and polysaccharide of P. gingivalis are
also pathological mediators in periodontal diseases.
AN - rayyan-563560924
AU - Imatani, T.
AU - Kato, T.
AU - Okuda, K.
DO - 10.1034/j.1399-302X.2001.016002065.x
IS - 2
KW - autacoid
cytokine
interleukin 1
interleukin 6
interleukin 8
lipopolysaccharide
article
biosynthesis
cell culture
culture medium
cytology
drug effect
fibroblast
gingiva
human
immunology
metabolism
nonparametric test
physiology
Western blotting
LA - English
PY - 2001
SN - 0902-0055
SP - 65-72
ST - Production of inflammatory cytokines by human gingival fibroblasts stimulated
by cell-surface preparations of Porphyromonas gingivalis
TI - Production of inflammatory cytokines by human gingival fibroblasts stimulated
by cell-surface preparations of Porphyromonas gingivalis
VL - 16
ID - 14298
ER -
TY - JOUR
AB - Objective: The intent to prepare and evaluate Linezolid in-situ gel in the
treatment of periodontitis. Methods: pH-sensitive in-situ gel was formed by the
cold method using a varying concentration of the drug, carbopol 934P and
hydroxypropyl methylcellulose (HPMC) and carbopol 934P and sodium carboxy
methylcellulose (CMC) (1:1,1:1.5,1:2,1:2.5). An optimized batch was selected based
on gelling time and gelling capacity. The prepared in-situ gels were evaluated for
appearance, pH, gelling capacity, viscosity, in vitro release studies, rheological
studies, and finally, was subjected to drug content estimation and antibacterial
activity test. Results: FTIR study shows drug and physical mixture were compatible
with each other. The rheology of formulated in-situ gel exhibited a pseudoplastic
flow pattern. this may be because when polymer concentration was increased the
prepared formulations become more viscous and in turn delayed the drug release and
from the prepared formulation, LF4 and SF4 have polymer concentrations i. e, 0.9%
carbopol and sodium CMC showed drug release up to 12 h. Conclusion: When carbopol
is appropriately mixed with other suitable polymers it forms an in-situ gel-forming
system that was substantiated by the property to transform into stiff gels when the
pH is increased. The in-situ gel was prepared using a combination of carbopol-HPMC
and carbopol-Na CMC The formulations LF1 to SF4 showed high linearity (R2 = 0.490-
0.682), indicating that the drug was released from the prepared in-situ gel by the
diffusion-controlled mechanism. Thus, the formulation of batches LF4 and SF4
containing carbopol: HPMC and carbopol: NaCMC in 1:2 ratios were considered as
optimum formulation based on optimum viscosity, gelling capacity and to extend the
in vitro drug release.
AN - rayyan-563559995
AU - Inayathulla
AU - Goudanavar, P.
AU - Ali, M.
AU - Wani, S. U. D.
AU - Sreeharsha, N.
DO - 10.22159/ijap.2021v13i3.40604
IS - 3
KW - hydroxypropylmethylcellulose
linezolid
methylcellulose
article
cold stress
cytotoxicity
delayed drug release
disk diffusion
drug formulation
drug release
drug synthesis
Escherichia coli
ethnicity
flow kinetics
measurement accuracy
nonhuman
periodontal disease
periodontal pocket
periodontitis
shear rate
LA - English
PY - 2021
SN - 0975-7058
SP - 79-86
ST - Formulation and evaluation of in-situ gel containing linezolid in the
T2 - Int. J. Appl. Pharm.
TI - Formulation and evaluation of in-situ gel containing linezolid in the
VL - 13
ID - 13369
ER -
TY - JOUR
AB - Objectives: The purpose of this study was to assess the efficacy of a gel
containing chlorhexidine and xanthan for the treatment of moderate-severe
periodontitis. Materials and methods: In this experimental study, we compared 15
patients (8 females and 7 males) with moderate-severe periodontitis who were
treated with Chlo-site and 1% chlorhexidine gel and a control group treated with
scaling and root planing. Results: The results of this preliminary analysis
revealed a pocket depth of 5 mm at the 3-month follow-up visit in the group treated
with the study gel. In contrast, pocket depths did not exceed 1 mm in the group
treated with chlorhexidine gel and in the control group. Conclusions: The data from
our study show that the combined use of gel with chlorhexidine and xanthan with
scaling and root planing is associated with increased recovery of pocket depth
compared with controls. © 2011 Elsevier Srl. All rights reserved.
AN - rayyan-563560591
AU - Incardona, M. G.
AU - Pacini, V.
AU - Ricci, M.
AU - Genovesi, A. M.
DO - 10.1016/j.pad.2011.03.001
IS - 2
KW - chlorhexidine
xanthan
article
clinical article
control group
disease severity
drug efficacy
female
follow up
human
male
periodontal disease
LA - Italian
PY - 2011
SN - ["0393-9960", "0393-9960"]
SP - 53-56
ST - Efficacy of a xanthan-based chlorhexidine gel for the treatment of
periodontal pockets
T2 - Utilizzo di un gel a base di clorexidina e xantano nel trattamento delle
tasche parodontali
TI - Efficacy of a xanthan-based chlorhexidine gel for the treatment of
periodontal pockets
VL - 37
ID - 13965
ER -
TY - JOUR
AB - Proteinases play a key rôle in the physiological degradation and remodelling
of the periodontal tissues. The rôle of these enzymes in tissue remodelling
remodelling in connection with the insertion of dental endosseous implants has not
been elucidated. Therefore, the aim of the present study was to identify the
eventual presence of collagenase, gelatinase and elastase activities in periimplant
sulcus fluid (PISF) of osseointegrated implants. Gelatinolytic activity in the
samples was studied with gelatin-zymograms. Collagenase activity and its
susceptibility to tetracycline-inhibition were monitored with SDS-polyacrylamide
gel electrophoresis and laser densitometry, and elastase activity with synthetic
substrate. Low activities of elastase and collagenase were detected in both PISF of
osseointegrated implant patients and gingival crevicular fluid (GCF) of the control
patients whereas significantly higher activities were detected in GCF of adult
periodontitis patients. Also the profiles of gelatinases were similar in PISF of
osseointegrated implant patients and GCF of the controls, but differed from the
profile of active gelatinases present in GCF of adult periodontitis patients. The
similar activities/characteristics of these proteinases in both periimplant sulcus
fluid of healthy dental implants and GCF of healthy natural teeth suggest that they
comprise the major proteinases for both periodontal and periimplant tissue
remodelling or destruction.
AN - rayyan-563561082
AU - Ingman, T.
AU - Könönen, M.
AU - Konttinen, Y. T.
AU - Siirilä, H. S.
AU - Suomalainen, K.
AU - Sorsa, T.
IS - 4
KW - collagenase
doxycycline
gelatinase
pancreatic elastase
titanium
adult
aged
article
bone regeneration
classification
drug antagonism
enzymology
female
fibroblast
gingiva bleeding
gingivitis
human
male
metabolism
middle aged
neutrophil
periodontitis
tooth
tooth implantation
tooth prosthesis
LA - English
PY - 1994
SN - 0303-6979
SP - 301-307
ST - Collagenase, gelatinase and elastase activities in sulcular fluid of
osseointegrated implants and natural teeth
TI - Collagenase, gelatinase and elastase activities in sulcular fluid of
osseointegrated implants and natural teeth
VL - 21
ID - 14456
ER -
TY - JOUR
AB - OBJECTIVE: To evaluate the effects of adjunctive delivery of a sodium
hypochlorite gel in the treatment of peri-implant mucositis (PM). MATERIALS AND
METHODS: Forty-six subjects with 68 implants diagnosed with PM were randomly
assigned to two treatment groups. Prior to mechanical debridement, a sodium
hypochlorite gel was delivered to the implants of the test group while implants of
the control group received a placebo gel. Application of both test and placebo gels
was repeated 5 times at baseline. The primary outcome variable was the change in
pocket probing depth (PPD) between baseline and 6 months. RESULTS: After 6 months,
the mean PPD decreased statistically significantly from 3.93 ± 1.09 mm to 3.04 ±
0.46 mm in the test (p = 0.0001) and from 3.68 ± 0.85 mm to 3.07 ± 0.58 mm in the
control (p = 0.0001) group, respectively. No statistically significant difference
(p = 0.53) was observed with respect to PPD changes from baseline to 6 months
between test (0.88 ± 1.04 mm) and control group (0.61 ± 0.75 mm), respectively. The
number of implants with bleeding on probing (BoP) decreased statistically
significantly from 33 to 18 in the test group (p = 0.0001) and from 34 to 23 in the
control group (p = 0.0001) after 6 months. CONCLUSIONS: In conclusion and within
the limits of the present study, changes in PPD from baseline to 6 months were not
statistically significantly different between groups. Complete resolution of
mucosal inflammation was not achieved with either of the therapies. CLINICAL
RELEVANCE: The present outcomes have showed that a complete resolution of peri-
implant mucositis is not possible to obtain by means mechanical debridement with or
without a sodium hypochlorite gel application.
AN - rayyan-563560120
AU - Iorio-Siciliano, V.
AU - Blasi, A.
AU - Stratul, S. I.
AU - Ramaglia, L.
AU - Sculean, A.
AU - Salvi, G. E.
AU - Rusu, D.
DO - 10.1007/s00784-019-03060-2
IS - 6
KW - hypochlorite sodium
complication
controlled study
gel
human
mucosa inflammation
periimplantitis
periodontal index
stomatitis
tooth implant
treatment outcome
LA - English
PY - 2020
SN - 1436-3771
SP - 1971-1979
ST - Anti-infective therapy of peri-implant mucositis with adjunctive delivery of
a sodium hypochlorite gel: a 6-month randomized triple-blind controlled clinical
trial
TI - Anti-infective therapy of peri-implant mucositis with adjunctive delivery of
a sodium hypochlorite gel: a 6-month randomized triple-blind controlled clinical
trial
VL - 24
ID - 13494
ER -
TY - JOUR
AB - BACKGROUND: The mechanical disruption and removal of the subgingival biofilm
represent the most important step in the treatment of periodontitis. However, in
deep periodontal pockets, mechanical removal of the subgingival biofilm is
difficult and frequently incomplete. Preliminary findings indicate that the use of
amino acid buffered sodium hypochlorite (NaOCl) gel may chemically destroy the
bacterial biofilm and facilitate its mechanical removal. OBJECTIVES: To clinically
evaluate the efficacy of minimally invasive nonsurgical therapy (MINST) of
periodontal pockets with or without local application of an amino acid buffered
sodium hypochlorite (NaOCl) gel. MATERIALS AND METHODS: Forty untreated patients
diagnosed with severe/advanced periodontitis (i.e. stage III/IV) with a
slow/moderate rate of progression (i.e. grade A/B) were randomly allocated in two
treatment groups. In the test group, the periodontal pockets were treated by means
of MINST and NaOCl gel application, while in the control group, treatment consisted
of MINST alone. Full-mouth plaque scores (FMPS), full-mouth bleeding scores (FMBS),
probing depths (PD), clinical attachment levels (CAL) and gingival recessions (GR)
were assessed at baseline and at 6 months following therapy. The primary outcome
variable was PD reduction at sites with PD ≥ 5 mm at baseline. RESULTS: At 6
months, statistically significant differences between the two groups were found (p
= 0.001) in terms of PD and CAL change. No statistically significant differences
were found in terms of GR (p = 0.81). The number of sites with PD ≥ 5 mm and BOP
(+) decreased statistically significantly (p = 0.001), i.e. from 85.3 to 2.2% in
the test group and from 81.6 to 7.3% in the control group, respectively.
Statistically significant differences between test and control groups were recorded
at 6 months (p = 0.001). MINST + NaOCl compared to MINST alone decreased
statistically significantly (p = 0.001) the probability of residual PDs ≥ 5 mm with
BOP- (14.5% vs 18.3%) and BOP+ (2.2% vs. 7.2%). CONCLUSIONS: Within their limits,
the present results indicate that (a) the use of MINST may represent a clinically
valuable approach for nonsurgical therapy and (b) the application of NaOCl gel in
conjunction with MINST may additionally improve the clinical outcomes compared to
the use of MINST alone. CLINICAL RELEVANCE: In patients with untreated
periodontitis, treatment of deep pockets by means of MINST in conjunction with a
NaOCl gel may represent a valuable approach to additionally improve the clinical
outcomes obtained with MINST alone.
AN - rayyan-563559970
AU - Iorio-Siciliano, V.
AU - Ramaglia, L.
AU - Isola, G.
AU - Blasi, A.
AU - Salvi, G. E.
AU - Sculean, A.
DO - 10.1007/s00784-021-03841-8
IS - 9
KW - hypochlorite sodium
controlled study
dental scaling
gingiva disease
human
periodontal pocket
periodontitis
treatment outcome
LA - English
PY - 2021
SN - 1436-3771
SP - 5331-5340
ST - Changes in clinical parameters following adjunctive local sodium hypochlorite
gel in minimally invasive nonsurgical therapy (MINST) of periodontal pockets: a 6-
month randomized controlled clinical trial
TI - Changes in clinical parameters following adjunctive local sodium hypochlorite
gel in minimally invasive nonsurgical therapy (MINST) of periodontal pockets: a 6-
month randomized controlled clinical trial
VL - 25
ID - 13344
ER -
TY - JOUR
AB - The recognition of periodontal diseases as amenable to local antibiotherapy
has resulted in a paradigmatic shift in treatment modalities of dental afflictions.
Moreover the presence of antimicrobial resistance, surfacing of untoward reactions
owing to systemic consumption of antibiotics has further advocated the use of local
delivery of physiologically active substances into the periodontal pocket. While
antimicrobials polymerized into acrylic strips, incorporated into biodegradable
collagen and lollow permeable cellulose acetate fibers, multiparticulate systems,
bio-absorbable dental materials, biodegradable gels/ointments, injectables,
mucoadhesive microcapsules and nanospheres will be more amenable for direct
placement into the periodontal pockets the lozenges, buccoadhesive tablets, discs
or gels could be effectively used to mitigate the overall gingival inflammation.
Whilst effecting controlled local delivery of a few milligram of an antibacterial
agent within the gingival crevicular fluid for a longer period of time, maintaining
therapeutic concentrations such delivery devices will circumvent all adverse
effects to non- oral sites. Since the pioneering efforts of Goodson and Lindhe in
1989, delivery at gingival and subgingival sites has witnessed a considerable
progress. The interest in locally active systems is evident from the patents being
filed and granted. The present Article shall dwell in reviewing the recent
approaches being proffered in the field. Patents as by Shefer, et al. US patent,
6589562 dealing with multicomponent biodegradable bioadhesive controlled release
system for oral care products, Lee, et al. 2001, US patent 6193994, encompassing a
locally administrable, biodegradable and sustained-release pharmaceutical
composition for periodontitis and process for preparation thereof and method of
treating periodontal disease as suggested by Basara in 2004via US patent 6830757,
shall be the types of intellectual property reviewed and presented in the current
manuscript. © 2008 Bentham Science Publishers Ltd.
AN - rayyan-563560729
AU - Iqbal, Z.
AU - Jain, N.
AU - Jain, G. K.
AU - Talegaonkar, S.
AU - Ahuja, A.
AU - Khar, R. K.
AU - Ahmad, F. J.
DO - 10.2174/187221108783331366
IS - 1
KW - ampicillin
anise oil
antibiotic agent
antiinfective agent
antioxidant
minocycline
doxycycline hyclate
bacitracin
camphor
chitosan
chlorhexidine
citronellal
clove oil
diclofenac
doxycycline
erythromycin
eucalyptus oil
lidocaine
metronidazole
microsphere
nanoparticle
nanosphere
peppermint oil
polyacrylic acid
polymer
tetracycline
toothpaste
unclassified drug
unindexed drug
chewing gum
clinical trial
dental procedure
dental etching
drug dose reduction
drug dose regimen
drug use
emulsion
encapsulation
gel
gingivitis
human
low drug dose
lozenge
microcapsule
mouth hygiene
mouth pain
mouth scaling
mouthwash
ointment
patent
periodontal disease
priority journal
review
taste disorder
actisite
arestin
atridox
dentomycin
elyzol
perio chip
LA - English
PY - 2008
SN - 1872-2113
SP - 58-67
ST - Dental therapeutic systems
TI - Dental therapeutic systems
VL - 2
ID - 14103
ER -
TY - JOUR
AB - We report a case of severe oral infection with a high fever due to
Lactobacillus rhamnosus during induction chemotherapy for acute myeloid leukemia.
The patient did not improve on treatment with meropenem, clindamycin, or vancomycin
until neutrophil recovery. Since L. rhamnosus GG is used in dairy products, and the
patient ingested dairy products daily before starting chemotherapy, we suspected an
association between the ingestion of dairy products and the development of
infection. Pulsed-field gel electrophoresis using two different restriction enzymes
showed that the strain isolated from the patient was identical to the L. rhamnosus
GG strain isolated from dairy products and ATCC #53103. This was confirmed by a PCR
assay with species-specific L. rhamnosus GG primers. Since Lactobacillus infection,
particularly L. rhamnosus infection, can be fatal in immunocompromised hosts, we
should consider Lactobacillus as a causative organism when Gram-positive rods are
detected during treatment with broad-spectrum antibiotics and vancomycin. The
causal association between the ingestion of dairy products containing Lactobacillus
and Lactobacillus infection in immunocompromised hosts warrants further study.
AN - rayyan-563560453
AU - Ishihara, Y.
AU - Kanda, J.
AU - Tanaka, K.
AU - Nakano, H.
AU - Ugai, T.
AU - Wada, H.
AU - Yamasaki, R.
AU - Kawamura, K.
AU - Sakamoto, K.
AU - Ashizawa, M.
AU - Sato, M.
AU - Terasako-Saito, K.
AU - Kimura, S. I.
AU - Kikuchi, M.
AU - Nakasone, H.
AU - Yamazaki, R.
AU - Kako, S.
AU - Nishida, J.
AU - Watanabe, K.
AU - Kanda, Y.
DO - 10.1007/s12185-014-1650-7
IS - 6
KW - cefepime
ceftazidime
cilastatin plus imipenem
clindamycin
cytarabine
granulocyte colony stimulating factor
idarubicin
itraconazole
levofloxacin
meropenem
micafungin
vancomycin
acute myeloid leukemia
acute monocytic leukemia
adult
antibiotic therapy
article
bacterial infection
case report
chromosome analysis
continuous infusion
dairy product
disease severity
drug substitution
fever
gene mutation
gingival biopsy
gingivitis
human
induction chemotherapy
Lactobacillus rhamnosus
Lactobacillus rhamnosus infection
male
mouth infection
mouth plaque
mouth ulcer
petechia
stomatitis
trisomy 8
LA - English
PY - 2014
SN - ["1865-3774", "0925-5710"]
SP - 607-610
ST - Severe oral infection due to Lactobacillus rhamnosus during induction
chemotherapy for acute myeloid leukemia
T2 - Int. J. Hematol.
TI - Severe oral infection due to Lactobacillus rhamnosus during induction
chemotherapy for acute myeloid leukemia
VL - 100
ID - 13827
ER -
TY - JOUR
AB - Periodontitis is a chronic inflammatory disease that causes gum tissue
degeneration and alveolar bone and tooth loss. The aim of this study is to develop
a multifunctional matrix for the treatment of periodontitis and enhancement of
regeneration of the periodontal tissue. The matrix was prepared from vitamin E
containing hydrogel made of alginate and gelatin, and doxycycline HCl containing
methoxy poly(ethylene glycol)-block-polycaprolactone micelles. Methoxy
poly(ethylene glycol)-block-polycaprolactone was synthesized with ring-opening
polymerization technique and characterized by proton nuclear magnetic resonance (1H
NMR), Fourier-transform infrared spectroscopy, differential scanning calorimetry,
and gel permeation chromatography. Micelles were characterized by measuring zeta
potential, hydrodynamic diameter, drug encapsulation efficiency, drug loading
capacity, and in vitro drug-release kinetics. Micelles were obtained with an
average size of 164 nm and drug loading amount of 5.8%. The activity of doxycycline
HCl–loaded micelles and vitamin E containing hydrogels was determined against
Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) with disk
diffusion method. Bio-efficacy of micelle-loaded alginate–gelatin hydrogels were
tested in vitro using L929 fibroblasts and dental pulp stem cells. Doxycycline HCl–
loaded micelles and vitamin E containing hydrogels showed a sustained release and
exhibited inhibition zone against E. coli and S. aureus. Hydrogels with vitamin E
and doxycycline HCl–loaded micelles promoted osteogenic differentiation of dental
pulp stem cells. Results suggest that alginate–gelatin hydrogels containing
doxycycline HCl–loaded micelles and vitamin E can be good candidates for the
treatment of periodontitis and tissue regeneration.
AN - rayyan-563560132
AU - Isik, G.
AU - Hasirci, N.
AU - Tezcaner, A.
AU - Kiziltay, A.
DO - 10.1177/0883911520911659
IS - 2
KW - alginic acid
alpha tocopherol
doxycycline
gelatin
hydrogel
methoxy poly(ethylene glycol) block polycaprolactone
polycaprolactone
unclassified drug
animal cell
article
bone development
controlled study
disk diffusion
drug release
encapsulation
Escherichia coli
fibroblast
hydrodynamics
in vitro study
micelle
mouse
nonhuman
particle size
periodontitis
polymerization
ring opening
synthesis
tissue regeneration
zeta potential
zone of inhibition
LA - English
PY - 2020
SN - ["1530-8030", "0883-9115"]
SP - 117-138
ST - Multifunctional periodontal membrane for treatment and regeneration purposes
T2 - J. Bioact. Compat. Polym.
TI - Multifunctional periodontal membrane for treatment and regeneration purposes
VL - 35
ID - 13506
ER -
TY - JOUR
AB - In recent years, statin group drugs have been widely investigated in
treatment of periodontal diseases due to their anti-inflammatory effect. The
efficacy of statins can be enhanced by local administration into the periodontal
pocket by appropriate delivery systems. The aim of our study was to develop a
bioadhesive delivery system for local delivery of atorvastatin in treatment of
periodontal disease. For this purpose, gel formulations were prepared using
different types of chitosan (base and water soluble) and viscosity, bioadhesivity
and syringeability of the gels as well as in vitro drug release properties were
investigated vitro. Furthermore, anti-inflammatory effect of the formulations was
studied in vitro using tumor necrosis factor (TNF)-alfa induced human gingival
fibroblast (hGF) cells. Release of proinflammatory (IL-1β IL-6, IL-8) and anti-
inflammatory (TGF-β1, TGF-β2, TGF-β3, IL-10) cytokines were measured after
incubating the hGF cells with the formulations. The viscosity of the formulations
was found to be suitable for a local application into periodontal pocket. In
presence of drug, bioadhesive property of the formulations was found to increase,
and bioadhesion force was within the range, which would retain the delivery system
at the application site, subsequently maintain drug levels at desired amount for
longer period of time. The release of atorvastatin from the gels was found to be
slower than that of the solution. The cytokine levels were found to decrease
following application of the formulations, and anti-inflammatory effect was
observed to enhance in presence of chitosan. No significant differences were found
between base and water-soluble chitosan.
AN - rayyan-563560231
AU - Işılay Özdoğan, A.
AU - Akca, G.
AU - Şenel, S.
DO - 10.1016/j.ejps.2018.08.037
KW - atorvastatin
chitosan
interleukin 10
interleukin 1beta
interleukin 6
interleukin 8
macrogol 400
poloxamer
adhesion
article
controlled study
cytokine release
drug efficacy
drug formulation
drug release
evaluation study
fibroblast
force
gel
gingival cell line
human
human cell
in vitro study
periodontal pocket
periodontitis
priority journal
viscosity
LA - English
PY - 2018
SN - ["1879-0720", "0928-0987"]
SP - 208-216
ST - Development and in vitro evaluation of chitosan based system for local
delivery of atorvastatin for treatment of periodontitis
TI - Development and in vitro evaluation of chitosan based system for local
delivery of atorvastatin for treatment of periodontitis
VL - 124
ID - 13605
ER -
TY - JOUR
AB - In this study, we focus on the antimicrobial properties of tempeh, a soybean
fermented food, against oral bacteria. Tempeh showed antimicrobial activity against
dental caries pathogenic bacterium Streptococcus mutans at a final concentration of
1 mg/mL. An antimicrobial substance contained in tempeh was present in the 100 kDa
or greater fraction generated by ultrafiltration, but it was found not to be
proteinaceous by native-PAGE, SDS-PAGE and protein degradation tests. Next, when
the fraction was purified with an ODS column, the 80% and 100% methanol eluates
showed antimicrobial activity against S. mutans. The 100% methanol eluate was
further subjected to a 2nd column purification, and isolation of the target was
confirmed by HPLC. When the isolated material was analyzed by ESI-MS, the m/z was
279.234. Further analysis by Raman spectroscopy revealed a peak similar to linoleic
acid. This substance also possessed antimicrobial properties equivalent to linoleic
acid.
AN - rayyan-563560111
AU - Ito, M.
AU - Ito, T.
AU - Aoki, H.
AU - Nishioka, K.
AU - Shiokawa, T.
AU - Tada, H.
AU - Takeuchi, Y.
AU - Takeyasu, N.
AU - Yamamoto, T.
AU - Takashiba, S.
DO - 10.1016/j.ijfoodmicro.2020.108645
KW - linoleic acid
methanol
article
controlled study
dental caries
fermentation
fermented product
mouth cavity
mouth flora
native polyacrylamide gel electrophoresis
nonhuman
protein degradation
Raman spectrometry
Rhizopus stolonifer
soybean
LA - English
PY - 2020
SN - ["1879-3460", "0168-1605"]
ST - Isolation and identification of the antimicrobial substance included in
tempeh using Rhizopus stolonifer NBRC 30816 for fermentation
T2 - Int. J. Food Microbiol.
TI - Isolation and identification of the antimicrobial substance included in
tempeh using Rhizopus stolonifer NBRC 30816 for fermentation
VL - 325
ID - 13485
ER -
TY - JOUR
AB - The regeneration of periodontal tissues is a decisive factor in the treatment
of periodontitis. Currently, to achieve complete periodontal regeneration, many
studies have evaluated the effectiveness of decellularized tissue-engineered
constructs on periodontal regeneration. We studied the possibilities of osteogenic
and odontogenic differentiation of periodontal progenitor and stem cells (SCs) of
the periosteum and periodontal ligament, in decellularized tooth matrix (dTM) and
periodontal ligament (dPDL), in 2D and 3D culture. The cell culture of periodontal
cells without decellularized matrices was used as control. On the 14th day of
cultivation of PDLSCs, PSCs, and PDLSCs + PSCs on dTM and/or dPDL scaffolds in 2D
conditions, in all scaffold variants, a dense monolayer of spindle-shaped cells was
intensely stained for markers of osteogenic differentiation, such as osteopontin
and osteocalcin. Periodontal cells in the collagen I hydrogel (3D-dimensional
culture) were more diverse in shape and, in combination of dTM and dPDL, in
addition to osteogenic expression, expressed dentin sialophosphoprotein, an
odontogenic differentiation marker. Thus, collagen I hydrogel contributed to the
formation of conditions similar to those in vivo, and the combination of dTM with
dPDL apparently formed a microenvironment that promoted osteogenic and odontogenic
differentiation of periodontal cells.
AN - rayyan-563559762
AU - Ivanov, A. A.
AU - Danilova, T. I.
AU - Kuznetsova, A. V.
AU - Popova, O. P.
AU - Yanushevich, O. O.
DO - 10.3390/biom13010122
IS - 1
KW - dental microscope
imaging software
immunohistochemical test kit
phase contrast microscope
tissue scaffold
chlorhexidine
collagen type 1
dentin sialophosphoprotein
hydrogel
osteocalcin
osteopontin
phosphoprotein
unclassified drug
article
bone development
cell culture
cell suspension
controlled study
decellularization
gene expression
histology
human
human cell
human tissue
morphology
odontoblast
osteoblast
periosteum
phase contrast microscopy
polymerization
protein expression
stem cell
tissue engineering
tissue regeneration
EnVision FLEX
ImageJ
LA - English
PY - 2023
SN - 2218-273X
ST - Decellularized Matrix Induced Spontaneous Odontogenic and Osteogenic
Differentiation in Periodontal Cells
T2 - Biomolecules
TI - Decellularized Matrix Induced Spontaneous Odontogenic and Osteogenic
Differentiation in Periodontal Cells
VL - 13
ID - 13136
ER -
TY - JOUR
AB - Periodontal disorders are among the most widespread chronic illnesses
globally which impact the tooth-supporting tissues and have a multitude of
ramifications for one's quality of life. The purpose of periodontal diagnostic
methods is to offer meaningful information to clinicians about the type, location,
and severity of periodontal disease so that disease monitoring and therapy may be
established. Due to a lack of proper molecular diagnostic tools, their early
detection is still difficult. Proteomics, the promising new "omics", has become an
important complementary tool to genomics providing novel information and greater
insight into biology. The value of multidimensional peptide resolving approaches in
the characterisation of complicated proteomes cannot be overstated and thus can
very much be used as diagnostic biomarkers in periodontal world. Since proteomics
is considered more intricate and complicated than genomics, the sound and rich
facts of proteins concerned in periodontitis can be applied in the analysis,
avoidance and management of periodontal diseases. Despite several novel protein
markers being recently enlisted by discovery proteomics through various methods
such as Enzyme Linked Immunosorbent Assay (ELISA), immunoassays with Mass
Spectroscopy (MS), Protein Topography and Migration Analysis platform (ProtoMap),
Matrix Assisted Laser Desorption (MALDI) etc., their routine diagnostic application
is hampered by the lack of validation platforms that can rapidly, accurately and
simultaneous quantify multiple proteins in large populations. Furthermore, saliva
contains a non invasively collected store of clinically relevant biomarkers, which,
if properly employed, might aid in early illness detection and monitoring. Hence,
in this context, this review aims to discuss the unravelling field of proteomics in
brief and the scientific sphere of its development from laboratory to clinical
practice and its implications in the field of periodontology.
AN - rayyan-563559898
AU - Ivaturi, M. S. S.
AU - Bhat, A. R.
DO - 10.7860/JCDR/2022/53091.16101
IS - 3
KW - apolipoprotein
calgranulin A
chlorhexidine
cystatin S
gelatinase A
haptoglobin
histatin
stromal cell derived factor 1
acetylation
alternative RNA splicing
bioinformatics
capillary electrophoresis
disease severity
DNA methylation
genetic regulation
genetic variation
gingivitis
glycosylation
human
isotope labeling
iTRAQ labeling
liquid chromatography-mass spectrometry
mass spectrometry
matrix-assisted laser desorption-ionization mass spectrometry
nitrosylation
nonhuman
periodontal disease
periodontitis
protein interaction
protein modification
proteomics
review
RNA translation
saliva analysis
sequence analysis
surface enhanced laser desorption ionization mass spectrometry
LA - English
PY - 2022
SN - ["0973-709X", "2249-782X"]
SP - ZE07-ZE13
ST - Exploring the Scope of Salivary Proteomics in Periodontal Diagnosis: A
Narrative Review
TI - Exploring the Scope of Salivary Proteomics in Periodontal Diagnosis: A
Narrative Review
VL - 16
ID - 13272
ER -
TY - JOUR
AB - The osseointegration of dental implants and their consequent long-term
success is guaranteed by the presence, in the extraction site, of healthy and
sufficient alveolar bone. Bone deficiencies may be the result of extraction
traumas, periodontal disease and infection. In these cases, placement of titanium
implants is contraindicated until a vertical bone augmentation is obtained. This
goal is achieved using bone graft materials, which should simulate extracellular
matrix (ECM), in order to promote osteoblast proliferation and fill the void,
maintaining the space without collapsing until the new bone is formed. In this
work, we design, develop and characterize a novel, moldable chitosan-pectin
hydrogel reinforced by biphasic calcium phosphate particles with size in the range
of 100–300 μm. The polysaccharide nature of the hydrogel mimics the ECM of natural
bone, and the ceramic particles promote high osteoblast proliferation, assessed by
Scanning Electron Microscopy analysis. Swelling properties allow significant
adsorption of water solution (up to 200% of solution content) so that the bone
defect space can be filled by the material in an in vivo scenario. The
incorporation of ceramic particles makes the material stable at different pH and
increases the compressive elastic modulus, toughness and ultimate tensile strength.
Furthermore, cell studies with SAOS-2 human osteoblastic cell line show high cell
proliferation and adhesion already after 72 h, and the presence of ceramic
particles increases the expression of alkaline phosphatase activity after 1 week.
These results suggest a great potential of the developed moldable biomaterials for
the regeneration of the alveolar bone. Statement of Significance The positive fate
of a surgical procedure involving the insertion of a titanium screw still depends
on the quality and quantity of alveolar bone which is present in the extraction
site. Available materials are basically hard scaffold materials with un-predictable
behavior in different condition and difficult shaping properties. In this work we
developed a novel pectin-chitosan hydrogel reinforced with ceramic particles.
Polysaccharides simulate the extracellular matrix of natural bone and the extensive
in vitro cells culture study allows to assess that the incorporation of the ceramic
particles promote a pro-osteogenic response. Shape control, easy adaption of the
extraction site, predictable behavior in different environment condition, swelling
properties and an anti-inflammatory response are the significant characteristics of
the developed biomaterial.
AN - rayyan-563560333
AU - Iviglia, G.
AU - Cassinelli, C.
AU - Torre, E.
AU - Baino, F.
AU - Morra, M.
AU - Vitale-Brovarone, C.
DO - 10.1016/j.actbio.2016.08.012
KW - bioceramics
calcium phosphate
chitosan
hydroxyapatite
interleukin 10
interleukin 1beta
interleukin 6
pectin
polyelectrolyte
alveolar bone
article
attenuated total reflectance infrared spectroscopy
bone growth
bone regeneration
cell adhesion
cell infiltration
cell proliferation
cell structure
controlled study
degradation
gene expression
human
human cell
hydration
hydrogel
in vitro study
inflammation
ossification
osteoblast
pH
polymerization
porosity
priority journal
SaOS-2 cell line
tensile strength
Young modulus
LA - English
PY - 2016
SN - ["1878-7568", "1742-7061"]
SP - 97-109
ST - Novel bioceramic-reinforced hydrogel for alveolar bone regeneration
T2 - Acta Biomater.
TI - Novel bioceramic-reinforced hydrogel for alveolar bone regeneration
VL - 44
ID - 13707
ER -
TY - JOUR
AB - Follicular dendritic cell-secreted protein (FDC-SP) is a secreted protein
expressed in follicular dendritic cells, periodontal ligament and junctional
epithelium. To elucidate the transcriptional regulation of the human FDC-SP gene by
tumor necrosis factor- (TNF-), we conducted real-time PCR, Western blotting,
transient transfection analyses with chimeric constructs of the FDC-SP gene
promoter linked to a luciferase reporter gene, gel mobility shift and chromatin
immunoprecipitation assays using Ca9-22 gingival epithelial cells. TNF- (10ng/ml)
induced FDC-SPmRNA and protein levels at 3hr and reached maximum at 12hr. In
transient transfection assays, TNF- (12hr) increased the LUC activities of
constructs between -116FDCSP and -948FDCSP including the human FDC-SP gene
promoter. Transcriptional stimulations by TNF- were partially inhibited in the -
345FDCSP constructs that included 3-bp mutations in the YY1, GATA, CCAAT enhancer-
binding protein 2 (C/EBP2) and C/EBP3. Transcriptional activities induced by TNF-
were inhibited by tyrosine kinase, MEK1/2 and phosphoinositide 3-kinase inhibitors.
The results of ChIP assays showed that YY1, GATA and C/EBP transcription factors
interacted with the YY1, GATA, C/EBP2 and C/EBP3 elements that were increased by
TNF-. These studies show that TNF- stimulates human FDC-SP gene transcription by
targeting YY1, GATA, C/EBP2 and C/EBP3 in the FDC-SP gene promoter.
AN - rayyan-563562562
AU - Iwai, Y.
AU - Noda, K.
AU - Yamazaki, M.
AU - Kato, A.
AU - Mezawa, M.
AU - Takai, H.
AU - Nakayama, Y.
AU - Ogata, Y.
DO - 10.1111/gtc.12561
IS - 3
PY - 2018
SN - ["1356-9597", "1365-2443"]
SP - 161-171
ST - Tumor necrosis factor- regulates human follicular dendritic cell-secreted
protein gene transcription in gingival epithelial cells
T2 - GENES TO CELLS
TI - Tumor necrosis factor- regulates human follicular dendritic cell-secreted
protein gene transcription in gingival epithelial cells
VL - 23
Y2 - 3
ID - 15936
ER -
TY - JOUR
AB - Clinical isolates of the periodontopathogen Aggregatibacter
actinomycetemcomitans form matrix-encased biofilms on abiotic surfaces in vitro. A
major component of the A. actinomycetemcomitans biofilm matrix is poly-β-1,6-N-
acetyl-d-glucosamine (PGA), a hexosamine-containing polysaccharide that mediates
intercellular adhesion. In this report, we describe studies on the purification,
structure, genetics and function of A. actinomycetemcomitans PGA. We found that PGA
was very tightly attached to A. actinomycetemcomitans biofilm cells and could be
efficiently separated from the cells only by phenol extraction. A.
actinomycetemcomitans PGA copurified with LPS on a gel filtration column. 1H NMR
spectra of purified A. actinomycetemcomitans PGA were consistent with a structure
containing a linear chain of N-acetyl-d-glucosamine residues in β(1,6) linkage.
Genetic analyses indicated that all four genes of the pgaABCD locus were required
for PGA production in A. actinomycetemcomitans. PGA mutant strains still formed
biofilms in vitro. Unlike wild-type biofilms, however, PGA mutant biofilms were
sensitive to detachment by DNase I and proteinase K. Treatment of A.
actinomycetemcomitans biofilms with the PGA-hydrolyzing enzyme dispersin B made
them 3 log units more sensitive to killing by the cationic detergent
cetylpyridinium chloride. Our findings suggest that PGA, extracellular DNA and
proteinaceous adhesins all contribute to the structural integrity of the A.
actinomycetemcomitans biofilm matrix. © 2007 Elsevier Ltd. All rights reserved.
AN - rayyan-563560725
AU - Izano, E. A.
AU - Sadovskaya, I.
AU - Wang, H.
AU - Vinogradov, E.
AU - Ragunath, C.
AU - Ramasubbu, N.
AU - Jabbouri, S.
AU - Perry, M. B.
AU - Kaplan, J. B.
DO - 10.1016/j.micpath.2007.08.004
IS - 1
KW - cetylpyridinium salt
complementary DNA
congo red
crystal violet
deoxyribonuclease I
detergent
DNA
hexosamine
kanamycin
n acetylglucosamine
poly beta 1,6 n acetyl dextro glucosamine
polysaccharide
proteinase K
unclassified drug
article
bacterial gene
bacterial infection
bacterium isolate
bacterium mutant
biofilm
carbohydrate analysis
gene locus
mouth cavity
mutagenesis
nonhuman
nucleotide sequence
periodontitis
pgaABCD gene
priority journal
structure analysis
transposon
LA - English
PY - 2008
SN - ["0882-4010", "1096-1208"]
SP - 52-60
ST - Poly-N-acetylglucosamine mediates biofilm formation and detergent resistance
in Aggregatibacter actinomycetemcomitans
T2 - Microb. Pathog.
TI - Poly-N-acetylglucosamine mediates biofilm formation and detergent resistance
in Aggregatibacter actinomycetemcomitans
VL - 44
ID - 14099
ER -
TY - JOUR
AB - Periodontitis considered as one of the main inflammatory disease that affect
teeth supporting tissue. Interleukin-6 (IL-6) is biologically active minor protein
molecules known as cytokines. Interleukin-6 (IL-6) is a multifunctional cytokine
playing a central role in inflammation and tissue injury. The aim of study was to
investigate the association between the Interleukin-6 (IL-6) _174 gene polymorphism
and susceptibility to periodontitis and body mass index (BMI) association with
periodontitis in Babylon province. The total subjects of the present study is 100,
divided into 2 groups; 60 subjects with periodontitis and 40 subjects healthy
controls, Un-stimulated salivary sample was taken from each subject and was
investigated for the presence of Interleukin-6 (IL-6) by using Polymerase chain
reaction (PCR) sequencing technique.Observed the difference is not important in the
distribution of Interleukin-6 (IL-6) rs1800796 genotypes between periodontitis
subjects and healthy subjects in this study also the BMI didn’t association with
periodontitis. The results suggests that Interleukin-6 (IL-6) rs1800796 gene
polymorphism wasn’t a putative risk factor for periodontitis and didn’t associated
with periodontitis
AN - rayyan-563560155
AU - Jabaar, H. A. A.
AU - Alamiedi, B. H. H.
AU - Hameed, M.
AU - Hashim, H. O.
IS - 2
KW - interleukin 6
adult
aged
article
body height
body mass
body weight
controlled study
disease severity
DNA extraction
DNA sequence
female
gene amplification
gene frequency
gene mutation
genetic association
genetic susceptibility
genotype
human
inflammation
male
periodontitis
questionnaire
sequence alignment
single strand conformation polymorphism
tissue injury
waist circumference
LA - English
PY - 2020
SN - ["0976-1772", "0972-5075"]
SP - 5259-5266
ST - MOLECULAR STUDY OF INTERLEUKIN-6 (IL-6) AMONG PERIODONTITIS IN BABYLON
PROVINCE
TI - MOLECULAR STUDY OF INTERLEUKIN-6 (IL-6) AMONG PERIODONTITIS IN BABYLON
PROVINCE
VL - 20
ID - 13529
ER -
TY - JOUR
AB - There is an unmet need for biocompatible, anti-infective, and mechanically
strong hydrogels. This study investigated the use of poly vinyl alcohol (PVA),
polysaccharides, and nanocrystalline cellulose (CNC) to deliver silver in a
controlled manner for possible use against oral or wound bacteria. Silver was
included in solvent cast films as silver diammine fluoride (SDF) or as nitrate,
sulphate, or acetate salts. Hydrogel formation was assessed by swelling
determinations and silver release was measured using inductively coupled plasma
methods. Antibacterial studies were performed using Gram-positive and negative
bacteria turbidity assays. PVA formed homogenous, strong films with SDF and swelled
gently (99% hydrolyzed) or vigorously with dissolution (88% hydrolyzed) and
released silver slowly or quickly, respectively. CNC-SDF films swelled over a week
and formed robust hydrogels whereas CNC alone (no silver) disintegrated after two
days. SDF loaded CNC films released silver slowly over 9 days whereas films
crosslinked with silver salts were less robust and swelled and released silver more
quickly. All silver loaded films showed good antibacterial activity. CNC may be
crosslinked with silver in the form of SDF (or any soluble silver salt) to form a
robust hydrogel suitable for dental use such as for exposed periodontal debridement
areas.
AN - rayyan-563561223
AU - Jackson, J.
AU - Dietrich, C.
AU - Shademani, A.
AU - Manso, A.
DO - 10.3390/gels7030104
IS - 3
J2 - Gels
LA - eng
N1 - Faculty of Pharmaceutical Sciences, University of British Columbia,
Vancouver, BC V6T 1Z3, Canada.; Department of Oral Health Sciences, Faculty of
Dentistry, The University of British Columbia, Vancouver, BC V6T 1Z3, Canada.;
Department of Microbiology and Immunology, The University of British Columbia,
Vancouver, BC V6T 1Z3, Canada.; Department of Biomedical Engineering, University of
British Columbia, Vancouver, BC V6T 1Z3, Canada.; Department of Oral Health
Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, BC
V6T 1Z3, Canada.
PY - 2021
ST - The Manufacture and Characterization of Silver Diammine Fluoride and Silver
Salt Crosslinked Nanocrystalline Cellulose Films as Novel Antibacterial Materials
TI - The Manufacture and Characterization of Silver Diammine Fluoride and Silver
Salt Crosslinked Nanocrystalline Cellulose Films as Novel Antibacterial Materials
VL - 7
Y2 - 7 y3 - 27
ID - 14597
ER -
TY - JOUR
AB - Background: Aim of the present meta-analysis was to evaluate the effect of
Aloe vera in various forms such as gel, mouthwash, and dentifrice on gingival and
plaque index (PI) in comparison to various allopathic products such as
chlorhexidine, metformin, chlorine dioxide, fluoridated toothpaste, and
alendronate. Materials and Methods: A comprehensive electronic search was conducted
on PubMed/MEDLINE, GOOGLE SCHOLAR, and HAND SEARCH of reference list of archived
articles published till January 2020. Randomized controlled trials were searched
comparing the Aloe vera product with other products which used PI and gingival
index (GI) to evaluate the outcomes. Finally, nine studies assessing PI and four
studies evaluating GI were considered for the meta-analysis. After extracting the
information, a risk of bias was estimated. The standardized mean differences (SMDs)
and fixed and random effect models were obtained from the mean treatment
differences. Results: The estimates of SMD of PI from fixed effects (SMD = 0.271,
95% confidence interval [CI] = 0.00134–0.407, P < 0.001) and random effects (SMD =
0.288, 95% CI = 0.048–0.529, P = 0.019) were found slightly different, the models
showed consistent results yielding positive and significant treatment effects. For
GI fixed effects (SMD = 0.27, 95% CI = −0.035–0.575, P = 0.0803, not significant)
and random effects (SMD = 0.259, 95% CI = 0.049–0.469, P = 0.016, significant) were
found slightly different and positive. However, one model showed significant and
another model showed nonsignificant treatment effects. Conclusion: Results from our
meta-analyses confirmed the beneficial effects of A. vera in improving the
periodontal parameters and hence may be considered as a safe alternative drug
delivery agent for the management of periodontal diseases in future.
AN - rayyan-563559972
AU - Jadhav, A. N.
AU - Rathod, S. R.
AU - Kolte, A. P.
AU - Bawankar, P. V.
DO - 10.4103/jisp.jisp_40_21
IS - 5
Aloe vera extract
chlorhexidine
chlorine dioxide
fluoride prophylaxis toothpaste
gel
metformin
mouthwash
Ocimum sanctum extract
ornigreat
tea tree oil
toothpaste
triclosan
adolescent
adult
aged
allopathy
Aloe vera
child
gingiva
gingival index
human
local therapy
meta analysis
nonhuman
outcome assessment
parameters
periodontal disease
periodontitis
plaque index
review
systematic review
therapy effect
LA - English
PY - 2021
SN - ["0975-1580", "0972-124X"]
SP - 372-378
ST - Effect of Aloe vera as a local drug delivery agent in the management of
periodontal diseases: A systematic review and meta-analysis
TI - Effect of Aloe vera as a local drug delivery agent in the management of
periodontal diseases: A systematic review and meta-analysis
VL - 25
ID - 13346
ER -
TY - JOUR
AB - Gold nanoparticles have been extensively used in diagnostics, biomedical
imaging, and drug delivery owing to simple method of synthesis and versatile
surface functionalization. Present investigation aims to evaluate the
osteoinductive property of Salacia chinensis (SC) mediated gold nanoparticles
(GNPs) for its application in implant dentistry. The formation of GNPs was assessed
initially using the visual method and characterized analytically by using UV-
visible spectroscopy, Zetasizer, X-RD, ICP-AES, AFM, and TEM. Green synthesized
GNPs exhibited a remarkable stability in various blood components (0.2 M histidine,
0.2 M cysteine 2% bovine serum albumin, and 2% human serum albumin) and were found
to be nontoxic when evaluated for their cytocompatibility and blood compatibility
using periodontal fibroblasts and erythrocytes respectively. Exposure of GNPs to
MG-63 cell lines displayed increased percent cell viability (138 +/- 27.4) compared
to the control group (96 +/- 3.7) which confirms its osteoinductive potential.
Herein, it can be concluded that the stable, biocompatible and eco-friendly GNPs
can be used as an effective bone inductive agent during dental implant therapy.
AN - rayyan-563562627
AU - Jadhav, K.
AU - Rajeshwari, H. R.
AU - Deshpande, S.
AU - Jagwani, S.
AU - Dhamecha, D.
AU - Jalalpure, S.
AU - Subburayan, K.
AU - Baheti, D.
DO - 10.1016/j.msec.2018.08.028
PY - 2018
SN - ["0928-4931", "1873-0191"]
SP - 664-670
ST - Phytosynthesis of gold nanoparticles: Characterization, biocompatibility, and
evaluation of its osteoinductive potential for application in implant dentistry
T2 - MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
TI - Phytosynthesis of gold nanoparticles: Characterization, biocompatibility, and
evaluation of its osteoinductive potential for application in implant dentistry
VL - 93
Y2 - 12 y3 - 1
ID - 16001
ER -
TY - JOUR
AB - Objective of this study was to formulate and evaluate an antimicrobial
mucoadhesive dental gel of herbal drugs for prevention and treatment of dental
plaque, dental caries and periodontitis. Azadirachta indica leaves extract was
prepared with ethanol: water (80:20 v/v) for 48 h under dark condition. Glycyrrhiza
glabra roots extract was prepared with ethanol: water (30:70 v/v) for 60 min at 50
° C. Both the extracts were evaluated for organoleptic properties, pH,
phytochemical screening and total phenolic content. Antibacterial activity of
extract was done on Mueller Hinton agar media against Streptococcus mutans using
disc diffusion method. Mucoadhesive gel was prepared using Carbopol 934, PEG 400 as
a bioadhesive polymer and permeation enhancer, respectively. Three (F1, F2 and F3)
gel formulation of Carbopol 934 were prepared at various concentrations 0.4%, 0.6%
and 0.8% w/v. Dental gel formulations were evaluated for different parameters such
as appearance, pH, viscosity, spreadabilty, syringeability. Optimised batch F2 was
used for further studies viz. stability study, drug content, diffusion study to
determine percent cumulative release of drug from gel formulation and in vitro
mucoadhesion study. 2.5% w/v of Azadirachta indica leaves extract showed good zone
of inhibition (10.66±0.577 mm) near to Chlorhexidine (11.33±0.5773 mm). 0.5% of
Glycyrrhiza glabra roots extract exhibit bioenhancing effect (9±1 mm) and mask
bitter taste of formulation. Batch (F2) was selected on the basis of viscosity,
spreadabilty and syringeability. The optimised batch was found to be stable and has
83% drug content. Percent cumulative release of drug from gel formulation during
diffusion study was found to be 87.52%, Adhesive force and adhesiveness were found
to be 11.90 g and 0.92 millijoule, respectively during mucoadhesion study. Results
of antimicrobial study shows that Azadirachta indica leaves extract has good
antibacterial activity. Glycyrrhiza glabra roots extract mask the bitter taste as
well as bioenhancing effect. Results of in vitro mucoadhesion study indicate that
the mucoadhesion gel was formulated with sufficient residence time of formulation.
AN - rayyan-563560233
AU - Jain, H. K.
AU - Gujar, K. N.
AU - Swami, P. N.
AU - Bhosale, S. R.
IS - 11
KW - adhesive agent
alcohol
carbopol 934
chlorhexidine
herbaceous agent
macrogol 400
phytochemical
water
agar medium
Azadirachta indica
bitter taste
conference abstract
controlled study
dental caries
disk diffusion
drug formulation
Glycyrrhiza glabra
human
in vitro study
mucoadhesion
nonhuman
periodontitis
pH
plant leaf
retention time
tooth plaque
viscosity
zone of inhibition
LA - English
PY - 2018
SN - 2455-3891
SP - 96
ST - Formulation and evaluation of an antimicrobial mucoadhesive dental gel
TI - Formulation and evaluation of an antimicrobial mucoadhesive dental gel
VL - 11
ID - 13607
ER -
TY - JOUR
AB - Objective: Objective of this study was to formulate and evaluate an
antimicrobial mucoadhesive dental gel of herbal drugs for the prevention and
treatment of dental plaque, dental caries, and periodontitis. Methods: Azadirachta
indica leaves extract was prepared with ethanol: water (80:20 v/v) and Glycyrrhiza
glabra roots extract was prepared with ethanol: water (30:70 v/v). Both the
extracts were evaluated for organoleptic properties, pH, phytochemical screening
and total phenolic content. Thin layer chromatography (TLC) and Reverse-phase high-
performance liquid chromatography (RP-HPLC) studies were performed. Antibacterial
activity of the extract was done on Mueller Hinton agar media against Streptococcus
mutans using the disc diffusion method. A mucoadhesive gel was prepared using
carbopol 934, polyethylene glycol (PEG) 400 as a bioadhesive polymer and
penetration enhancer, respectively. Three gel formulations were prepared at various
concentrations of carbopol 934. Dental gel formulations were evaluated for
different parameters such as appearance, pH, viscosity, spreadabilty,
syringeability. Optimised batch was used for further studies viz. stability study,
drug content, diffusion study to determine percent cumulative release of drug from
gel formulation and in vitro mucoadhesion study. Results: Rf value of nimbin and
glycyrrhizin in TLC study, were found to be 0.08 and 0.56, respectively. RP-HPLC
method was developed for estimation of active constituents present in both extracts
using mobile phase acetonitrile: water [containing 0.1% v/v glacial Acetic acid
(GAA)]: methanol in the ratio of 30:60:10 at the flow rate of 0.8 ml/min. Rt of
active constituents from both drug extracts was found to be 3.119 and 4.15 min,
respectively. 2.5% w/v of Azadirachta indica leaves extract showed a good zone of
inhibition (10.66±0.577 mm) near to chlorhexidine (11.33±0.5773 mm). 1% of
Glycyrrhiza glabra roots extract exhibit antibacterial activity (9±1 mm) and masks
the bitter taste of formulation. Batch (F2) was selected on the basis of viscosity,
spreadabilty and syringeability. The optimised batch was found to be stable and has
83% and 80.3% of drug content. Percent cumulative releases of the drug from gel
formulation during the diffusion study were found to be 87.52% and 85.43%. Adhesive
force and adhesiveness were found to be 11.90 g and 0.92 millijoule, respectively
during mucoadhesion study. Conclusion: The evaluation parameters of optimized batch
indicate the prepared dental gel is mucoadhesive, stable, good delivery drug system
containing antimicrobial agents for prevention of plaque formation, dental caries
and periodontitis.
AN - rayyan-563560196
AU - Jain, H. K.
AU - Swami, P. N.
AU - Gujar, K. N.
DO - 10.22159/ijap.2019v11i2.29723
IS - 2
KW - spectrometer
acetic acid
antiinfective agent
chlorhexidine
disodium hydrogen phosphate
gallic acid
Glycyrrhiza glabra extract
glycyrrhizic acid
nimbin
phytochemical
toothpaste
article
Azadirachta indica
controlled study
disk diffusion
drug formulation
drug release
drug synthesis
gel
Glycyrrhiza glabra
mucoadhesion
nonhuman
physical chemistry
phytochemistry
thin layer chromatography
LA - English
PY - 2019
SN - 0975-7058
SP - 176-184
ST - Formulation and evaluation of an antimicrobial mucoadhesive dental gel of
Azadirachta indica and Glycyrrhiza glabra
TI - Formulation and evaluation of an antimicrobial mucoadhesive dental gel of
Azadirachta indica and Glycyrrhiza glabra
VL - 11
ID - 13570
ER -
TY - JOUR
AB - BACKGROUND: The role of chemotherapeutic agents in periodontal therapy as
adjuncts to mechanical debridement maybe justified by the inherent limitations of
mechanical therapy. The aim of this study was to evaluate the long term efficacy of
a locally delivered 2% minocycline gel as an adjunct to scaling and root planing in
managing chronic periodontitis. MATERIALS AND METHODS: This was a randomized
controlled trial using a split-mouth study design. Twenty two pairs of sites with
similar probing depths were randomly allocated to test and control groups. All
sites received thorough scaling and root planing followed by minocycline gel
application in the test sites. Probing depths, relative attachment levels, plaque
index, and microbiological parameters were evaluated for both the groups over a 9-
month period. RESULTS: Overall parameters improved from baseline in both the test
and control groups. For most parameters, the differences between test and control
groups were not significant at different time intervals. The probing depth values
in the test group at six (3.64±0.83 mm) and nine months (3.81±0.79 mm) were
significantly less than control group(4.24±0.95 mm at six and 4.63±0.94 mm at nine
months), these differences being significant at P<0.05 and <0.01, respectively. At
the end of nine months, the number of non-motile bacilli in test group (21.65±3.74)
were significantly less than control group (25.5±3.01), the difference being
significant at P<0.02. CONCLUSION: The overall view of results in our investigation
did not show any significant advantage of using 2% minocycline gel over scaling and
root planning as an effective local drug delivery system and calls for further
clinical trials to objectively evaluate its adjunctive in treatment of
periodontitis.
AN - rayyan-563561384
AU - Jain, R.
AU - Mohamed, F.
AU - Hemalatha, M.
DO - 10.4103/0972-124X.99259
IS - 2
LA - eng
N1 - Department of Periodontics, Christian Dental College, Ludhiana, India.
PY - 2012
SP - 179-83
ST - Minocycline containing local drug delivery system in the management of
chronic periodontitis: A randomized controlled trial
TI - Minocycline containing local drug delivery system in the management of
VL - 16
Y2 - 4
ID - 14758
ER -
TY - JOUR
AB - Introduction: Natural herbal remedies have shown promising anti-microbial
property and fewer side effects compared to synthetic anti-microbial therapy. Aloe
Vera is a medicinal plant used for management of various infections since ancient
times as it has anti-inflammatory, anti-microbial, and immune-boosting properties.
Aim: The aim of the present study was to determine the anti-microbial and
inhibitory activities of various concentration of Aloe Vera Gel (AVG) against oral
pathogenic bacteria. Materials and Methods: Subgingival calculus and aspiration of
periapical abscess and periodontal abscess was done in 20 patients and the sample
transferred to thioglycolate broth, which was incubated in Mutans Sanguis agar,
blood agar and cultured in anaerobic gas chamber. The colonies formed were
identified further by gram staining methods and biochemical fermentation tests
(IMViC). Each isolated colony of identified bacteria were cultured separately in
Muller-Hilton broth and incubated at 37°C for 24 hours. Anti-microbial activity of
the AVG was tested by the disc diffusion method and minimum inhibitory
concentration was determined by broth micro-dilution method. Result: Various
staining and biochemical tests confirmed that the sample contained Actinobacillus
actinomycetemcomitans (A. actinomycetemcomitans), Clostridium bacilli (C. bacilli),
Streptcoccus mutans (S. mutans) and Staphlococcus aureus (Staph. aureus). AVG
showed anti-bacterial property at 100% and 50% concentration (‘t’ value = 7.504, p-
value <0.001). At lower concentration there was no effect against the bacteria. At
100% AVG concentration, zone of inhibition measured was 6.9mm in A.
actinomycetemcomitans, 6.3mm in C. bacilli, 6.8mm in S. mutans and 6.6mm in Staph.
aureus. The standard drugs were also used to compare anti-bacterial property of
AVG. Result showed that higher concentration (100%, 50%) of AVG has comparable zone
of inhibition with Ofloxacin (5mcg) and Ciprofloxacin (30mcg). Conclusion: AVG at
higher concentration showed anti-bacterial property and can be used as a promising
adjunct for oral health care.
AN - rayyan-563560328
AU - Jain, S.
AU - Rathod, N.
AU - Nagi, R.
AU - Sur, J.
AU - Laheji, A.
AU - Gupta, N.
AU - Agrawal, P.
AU - Prasad, S.
DO - 10.7860/JCDR/2016/21450.8890
IS - 11
ciprofloxacin
ofloxacin
Aloe vera
article
bacterium culture
bacterium isolation
clinical article
Clostridium
dental curettage
disk diffusion
human
in vitro study
zone of inhibition
mouth flora
mouth infection
periodontal abscess
LA - English
PY - 2016
SN - ["0973-709X", "2249-782X"]
SP - ZC41-ZC44
ST - Antibacterial effect of aloe vera gel against oral pathogens: An in-vitro
study
TI - Antibacterial effect of aloe vera gel against oral pathogens: An in-vitro
study
VL - 10
ID - 13702
ER -
TY - JOUR
AB - Introduction: Evaluating on different ways to treat periodontal pocket for
changing clinical index such as PBI,PPD,CAL. Materials and methods: 14 patients
with 66 teeth that have 4-7mm periodontal pocket depth were chosen and divided into
three equal groups.first group was trea-ted by SRP (scaling-root planning) and
second group by SRP+chlosite as a chlorhexidine gel and third one treated by
SRP+980nm diode laser .clinical index such as PBI (papillary bleeding Index),
PPD(periodontal pocket depth), CAL(clinical attachment level), and the quantity of
aerobic bacterial colonies were evaluated in the first, third and seventh weeks and
three months later. The one way ANOVA analysis was used in the beginning of the
study and repeated measures ANOVA analysis at the end. Results: The periodontal
pocket depth was reduced in all three groups and we had a significant difference
bet-ween the group by using laser and two other groups. Although we had good
results in other three index (CAL-PBI-Bacterial colonies), we did not have
significant differences. The important result of this study was a significant
difference between two groups were treated by adjunctive therapy (SRP+Chlorhexidine
or Laser) compare to only SRP. Conclusion: To sum up, not only adjunctive
periodontal pocket therapy is much better than the conventional pocket therapy, but
also 980nm diode laser can reduce PPD.
AN - rayyan-563560552
AU - Jalali, S.
DO - 10.4317/medoral.17643579
KW - chlorhexidine
tuberculin
periodontics
diode laser
laser
dentistry
comparative study
periodontal pocket
therapy
bacterium colony
planning
tooth
human
patient
bleeding
LA - English
PY - 2012
SN - 1698-4447
SP - S80
ST - Comparative study on periodontics clinical index by using diode laser and
chlorhexidine gel
T2 - Med. Oral Patol. Oral Cir. Bucal
TI - Comparative study on periodontics clinical index by using diode laser and
chlorhexidine gel
VL - 17
ID - 13926
ER -
TY - JOUR
AB - Aim: The aim of the current research was to evaluate the antimicrobial
effectiveness of chitosan-based tetracycline gel on periodontal pathogenic
microorganisms. Materials and Methods: Preparation of chitosan-based tetracycline
gel of 0.7% and 1% was done. In addition, 0.2 g of chitosan, 1% citric acid, and
then 0.35 g of tetracycline in that order was added. Furthermore, 0.5 g of the
tetracycline, which had been subjected to crushing and then stirring in a glass
beaker to obtain a homogeneous gel was subjected to insertion into the syringe
sterile. Such material prepared at the instance will attempt to investigate the
sensitivity of bacteria in Surabaya to preserve the steadiness of the material.
Evaluation of antimicrobial outcomes of chitosan-based tetracycline gel was
performed against Actinobacillus actinomycetemcomitans and Porphyromonas
gingivalis. Results: The highest region of inhibition was noted at 28.26 ± 1.08 mm,
23.98 ± 2.02 mm against A. actinomycetemcomitans and P. gingivalis at 1% chitosan-
based tetracycline gel, in pursuit by the 0.7% chitosan-based tetracycline gel at
15.12 ± 0.16 mm and 14.48 ± 1.22 mm region of inhibition, followed by a control
group that exhibited 4.16 ± 1.29 mm and 4.82 ± 1.20 mm regions of inhibition
against either of the pathogens. Conclusion: To conclude, the chitosan-based
tetracycline gel is efficient in restraining the growth of A. actinomycetemcomitans
and P. gingivalis bacteria. Tetracycline 1% gel-based chitosan exhibited maximum
antibacterial action since it depicted the maximum inhibition region diameter
versus tetracycline gel 0.7%.
AN - rayyan-563559697
AU - Jalaluddin, M.
AU - Kulkarni, A.
AU - Raj, K.
AU - Kumari, D.
AU - Devi, K. B.
AU - Vineeth, N. S.
DO - 10.4103/jpbs.jpbs_532_22
IS - 5
KW - laboratory device
syringe
chitosan
citric acid
gel
tetracycline
article
bacterial growth
comparative study
controlled study
drug efficacy
growth inhibition
in vitro study
nonhuman
periodontium
zone of inhibition
LA - English
PY - 2023
SN - 0975-7406
SP - S438-S441
ST - Assessment of antimicrobial efficacy of chitosan-based tetracycline gel on
periodontal pathogens: An in vitro study
TI - Assessment of antimicrobial efficacy of chitosan-based tetracycline gel on
periodontal pathogens: An in vitro study
VL - 15
ID - 13071
ER -
TY - JOUR
AN - rayyan-563561192
AU - Jame, F.
AU - Pourquier
AU - Abdel Hafeez, A.
IS - 139
KW - chlorhexidine
fluoride
hydrochloric acid
animal
article
comparative study
female
gel
gingivitis
male
Leporidae
tooth plaque
LA - French
PY - 1981
SP - 19-21
ST - Prevention of gingival disease. Comparative study of 4 drug products:
habitane, a bifluoride gel, 0.2% HCl and 0.1% HCl
T2 - Prévention des gingivopathies. Etude comparative de 4 produits chimiques:
l'Hibitane, le gel bifluoré, l'HCl 0,2% et l'HCl 0,1%.
TI - Prevention of gingival disease. Comparative study of 4 drug products:
habitane, a bifluoride gel, 0.2% HCl and 0.1% HCl
VL - 21
ID - 14566
ER -
TY - JOUR
AN - rayyan-563562067
AU - Jame, O.
AU - Orti, V.
AU - Bousquet, P.
AU - Calas, I.
AU - Gibert, P.
DO - 10.1016/j.emcden.2003.09.002
IS - 1
PY - 2004
SP - 49-54
ST - Use of antiseptics in periodontology
T2 - EMC-Dentisterie
TI - Use of antiseptics in periodontology
3242692327&doi=10.1016%2fj.emcden.2003.09.002&partnerID=40&md5=0d3592ae9685a593214b
95fd41fc87f0
VL - 1
ID - 15441
ER -
TY - JOUR
AB - Gram-negative, anaerobic bacterias are predominate in periapical infections.
The bacterial lipopolysaccharide (LPS) initiates the process of inflammation and
periapical bone resorption. Usage of various medicaments retards or inactivates the
bacterial endotoxin (LPS). However, the results are not highly effective. In recent
years, owing to antimicrobial resistance, the shift from conventional agents to
herbal agents has been increased tremendously in research. Keeping this in mind,
the present study was formulated to evaluate the efficacy of oregano essential oil
in inhibiting bacterial LPS- induced osteoclastogenesis. Four different
concentrations (0 ng/mL, 25 ng/mL, 50 ng/mL, and 100 ng/mL) of oregano essential
oil extract were added into 96-well culture plate. Under light microscope,
quantification of osteoclast cells was performed. One-way ANOVA with post-hoc Tukey
test was carried out on SPSS v21. A significant reduction (p < 0.001) in the
osteoclast was observed in the experimental groups compared to no oregano essential
oil extract (control). A dose-dependent significant reduction (p < 0.001) in
osteoclast formation was observed among the experimental groups, with lesser
osteoclast seen in group IV with 100 ng/mL of oregano essential oil extract. Thus,
it can be concluded that oregano essential oil extract can be utilized as a
therapeutic agent that can target bacterial LPS-induced osteoclastogenesis.
However, randomized controlled studies should be conducted to assess the potential
use of this extract in the periapical bone resorption of endodontic origin.
AN - rayyan-563562634
AU - Janani, K.
AU - Teja, K. V.
AU - Alam, M. K.
AU - Shrivastava, D.
AU - Iqbal, A.
AU - Khattak, O.
AU - Al-Johani, K.
AU - Hamza, M. O.
AU - Jose, J.
AU - Karobari, M. I.
AU - Srivastava, K. C.
DO - 10.3390/separations8120240
IS - 12
PY - 2021
SN - 2297-8739
ST - Efficacy of Oregano Essential Oil Extract in the Inhibition of Bacterial
Lipopolysaccharide (LPS)-Induced Osteoclastogenesis Using RAW 264.7 Murine
Macrophage Cell Line-An In-Vitro Study
T2 - SEPARATIONS
TI - Efficacy of Oregano Essential Oil Extract in the Inhibition of Bacterial
Lipopolysaccharide (LPS)-Induced Osteoclastogenesis Using RAW 264.7 Murine
Macrophage Cell Line-An In-Vitro Study
VL - 8
Y2 - 12
ID - 16008
ER -
TY - JOUR
AB - AIM: To compare anti plaque efficacy of Cure next gel, Hoira-SA gel (Natural
Herb Extracts) with Chlorhexidine gel among patients with mild to moderate
gingivitis. OBJECTIVE: The objective of the study is to compare the anti-plaque
efficacy of Natural Herb Extract Gels (Cure Next gel and Hoira-SA Gel) with
Chlorhexidine gel in reducing plaque accumulation, gingival inflammation among
patients with mild to moderate gingivitis. MATERIALS AND METHOD: 45 systemically
healthy mild to moderate gingivitis patients are to be selected from the outpatient
department of Saveetha Dental College. Patients were divided into three groups
where in Group 1 (GP1) included 15 patients provided with Cure Next Sample, Group 2
(GP2) included 15 patients provided with Chlorhexidine sample; Group 3 (GP3)
included 15 patients with Hoira-SA gel sample. Following randomization, the
baseline values were recorded and supra gingival scaling and polishing was done.
Patient was allotted in one of the three groups and instructions about usage of gel
were given. Postoperative assessment was done after two weeks using Plaque Index
and Bleeding Index. RESULT: There was a significant reduction found in the levels
of mean plaque and bleeding scores assessed post operatively after two weeks of
administration of gel samples in all the three groups. The plaque and bleeding
scores were compared between the groups to assess the anti-plaque efficacy of the
gel samples in comparison with chlorhexidine gel. CONCLUSION: This study revealed
that all the three gels (Cure next gel, Chlorhexidine gel and Hoira gel) can be
effectively used in plaque control for mild to moderate gingivitis patients. But
while comparing Cure Next gel with Hoira gel, Cure next gel administration showed
significant reduction in plaque accumulation similar to that of Chlorhexidine gel.
AN - rayyan-563560246
AU - Janani
AU - Gajendran, P. L.
DO - 10.5958/0974-360X.2018.00677.7
IS - 8
KW - chlorhexidine
curcumin extract
cure next
hoira sa
jasmine extract
plant extract
unclassified drug
adult
anti plaque activity
article
bleeding
clinical article
clinical assessment
controlled study
dental caries
drug activity
gingiva bleeding
gingivitis
human
inflammation
postoperative care
tooth plaque
LA - English
PY - 2018
SN - ["0974-360X", "0974-3618"]
SP - 3689-3692
ST - Anti–plaque efficacy of cure next gel, hoira-sa gel in comparison with
chlorhexidine gel. A randomised control trial study
TI - Anti–plaque efficacy of cure next gel, hoira-sa gel in comparison with
chlorhexidine gel. A randomised control trial study
VL - 11
ID - 13620
ER -
TY - JOUR
AB - Objectives: The phytochemical composition of Ocimum tenuiflorum is highly
complex and enriched with nutrients and other biologically active compounds. The
aim of this randomized clinical trial was to explore the antimicrobial and anti-
gingivitis property of 2 % O. tenuiflorum extract gel with 0.2 % chlorhexidine gel
on patients diagnosed with dental plaque induced gingival inflammation as an
adjunct to oral prophylaxis. Materials and methods: 60 patients diagnosed with
moderate to severe form of gingivitis, fulfilling the inclusion criteria
participated in this randomized double-blind placebo-controlled trial. Following
oral prophylaxis, the subjects were randomly dispensed with one of the test gels
i.e., Group A – 0.2 % Chlorhexidine gel (n = 20), Group B – placebo gel (n = 20),
Group C –2% O. tenuiflorum gel (n = 20) for 15 days. Clinical indices (Plaque index
(PI), gingival index (GI) and modified Sulcus Bleeding index (mSBI)) and
microbiological parameters were recorded at baseline, 15 days, and 3 months.
Results: All 3 groups exhibited a reduction in clinical (PI, GI, mSBI) and
microbiological parameters (p < 0.001). O. tenuiflorum gel and chlorhexidine gel
showed a statistically significant improvement in gingival health as compared to
the placebo gel at all study time intervals. An increase in clinical parameters
were observed from the 15th day to the 3rd month recall interval. However, it did
not return to pre-treatment levels. The present study revealed that O. tenuiflorum
gel was equally effective in reducing plaque and gingivitis compared to standard
chlorhexidine gel within the study timelines. Conclusion: O. tenuiflorum gel has
shown enhanced effects on gingival health due to its therapeutic properties and may
be considered an alternative adjunct to mechanical plaque control therapy.
AN - rayyan-563559953
AU - Jankish, A.
AU - Varghese, J.
AU - Shenoy, V. P.
AU - U, V.
AU - Khan, S.
AU - Kamath, V.
DO - 10.1016/j.hermed.2021.100478
KW - CTRI/01/011175
incubator
Infinite M200
microplate
microplate reader
antiinfective agent
carbopol 934
chlorhexidine
cisplatin
elugel
gel
Ocimum tenuiflorum extract
placebo
plant extract
unclassified drug
adult
animal cell
article
cell viability
colony forming unit
controlled study
dental prophylaxis
dental scaling
drug cytotoxicity
female
gingival index
gingivitis
human
male
mouth hygiene
nonhuman
parallel design
plant leaf
plaque index
prospective study
tooth plaque
LA - English
PY - 2021
SN - ["2210-8041", "2210-8033"]
ST - Comparative evaluation of antimicrobial and anti-gingivitis effect of Ocimum
tenuiflorum Linn. gel with 0.2% chlorhexidine gel – Randomized controlled clinical
trial
T2 - J. Herbal Med.
TI - Comparative evaluation of antimicrobial and anti-gingivitis effect of Ocimum
tenuiflorum Linn. gel with 0.2% chlorhexidine gel – Randomized controlled clinical
trial
VL - 29
ID - 13327
ER -
TY - JOUR
AB - Periodontal disease is an infectious disease initiated by microbial plaque,
which accumulates on the tooth surface at the gingival margin and induces an
inflammatory reaction. The function of the inflammatory process is to protect the
host, however the process may also contribute to tissue destruction. Most
individuals show gingival inflammation, but only a limited number suffer from
periodontitis i.e. loss of attachment. Without treatment, periodontitis will result
in tooth mobility and subsequent tooth mortality. Independent of ethnicity, 10%-15%
of an adult population will develop severe periodontitis The aim of this thesis has
been to analyse individuals at risk for periodontal disease. Four studies have been
conducted in 2 different groups of individuals with: Recurrent periodontitis kept
in a maintenance care program--studies I-III. Type 2 diabetes (T2D)--study IV. In
study I, the clinicaleffect of local periodontitis treatment with an antibiotic gel
was investigated. In study II, the microbiologicaleffect of periodontitis treatment
with the same antibiotic gel as in study I was investigated. In study III, it was
investigated whether the interleukin-l (IL-1alpha and beta) and interleukin-6 (IL-
6) gene polymorphisms were associated with the susceptibility of chronic
periodontitis. In study IV, the prevalence of periodontitis in individuals with T2D
was investigated, together with the prevalence of diabetic complications in
relation to periodontal disease. We also studied whether there was a difference in
dental care habits and knowledge of oral health between T2D subjects with and
without periodontal disease. In conclusion, this thesis did not find any
significant clinical and microbiological differences between subjects with
recurrent periodontal disease treated with a locally delivered metronidazole gel
compared to a placebo gel. Neither could we find an association between genetic
variants in the IL-lalpha, IL-beta and IL-6 genes in individuals with or without
periodontal disease. The prevalence of severe periodontitis, according to
radiographic criteria, was almost 20% in subjects with T2D. This was further
confirmed by clinical parameters. T2D individuals with periodontal disease
demonstrated a higher HbAlc level, a higher prevalence of cardiovascular
complications and a higher proportion of smokers compared to periodontally healthy
T2D subjects. Finally, T2D individuals seem to lack sufficient knowledge about oral
health.
AN - rayyan-563560767
AU - Jansson, H.
IS - 180
KW - acylglycerol
antiinfective agent
drug derivative
Elyzol Dentalgel
interleukin 1
interleukin 6
metronidazole
sesame seed oil
adult
article
chronic disease
female
genetic predisposition
genetics
genotype
human
male
middle aged
mouth hygiene
periodontal disease
periodontics
periodontitis
recurrent disease
risk factor
LA - English
PY - 2006
SN - 0348-6672
SP - 5-49
ST - Studies on periodontitis and analyses of individuals at risk for periodontal
diseases
T2 - Swed Dent J Suppl
TI - Studies on periodontitis and analyses of individuals at risk for periodontal
diseases
ID - 14141
ER -
TY - JOUR
AB - Background: The aim of this study was to evaluate the clinical outcome in
patients with recurrent periodontal disease following treatment with 25%
metronidazole gel. Methods: Twenty subjects in a maintenance care program but with
recurrent periodontal disease participated. Three months after scaling and root
planing, a total of 40 sites, 2 in each patient, with probing depth ≥5 mm were
selected. One site randomly selected was treated with metronidazole gel (test) and
the other site with a placebo gel (control). Baseline and follow-up measurements
included plaque index (PI), gingival index (GI), bleeding on probing (BOP), probing
depth (PD), and clinical attachment level (CAL). Results: There were no
statistically significant differences in PI, GI, BOP, PD, or CAL between test and
control sites. Conclusion: This study showed that local treatment with 25%
metronidazole gel did not seem to influence the clinical healing in this group of
subjects with recurrent periodontal disease.
AN - rayyan-563560888
AU - Jansson, H.
AU - Bratthall, G.
AU - Söderholm, G.
DO - 10.1902/jop.2003.74.3.372
IS - 3
KW - metronidazole
placebo
article
bleeding
clinical article
controlled study
drug formulation
follow up
gel
gingiva
healing
human
periodontal disease
periodontics
recurrent disease
reproducibility
tooth plaque
treatment outcome
LA - English
PY - 2003
SN - 0022-3492
SP - 372-377
ST - Clinical outcome observed in subjects with recurrent periodontal disease
following local treatment with 25% metronidazole gel
TI - Clinical outcome observed in subjects with recurrent periodontal disease
following local treatment with 25% metronidazole gel
VL - 74
ID - 14262
ER -
TY - JOUR
AB - The aim of this study was to evaluate the microbial outcome in patients with
recurrent periodontal disease following treatment with 25% metronidazole gel using
the polymerase chain reaction (PCR). Twenty subjects in a maintenance care program
but with recurrent periodontal disease participated. Three months after scaling and
root planing a total of 40 sites, 2 in each patient, with pocket probing depth of >
or = 5 mm were selected. One site randomly selected was treated with 25%
metronidazole gel (test) and the other site with a placebo gel (control). A
bacterial sample was collected on paperpoint from each test and control site at
baseline and 12 weeks after treatment. The following pathogens were analysed and
detected with PCR:Actinobacillus actinomycetemcomitans (A.a.), Porphyromonas
gingivalis (P.g.) and Prevotella nigrescens (P.n.). At baseline, A.a., P.g. and
P.n. were detected in 30, 60 and 70% of all test sites and in 32, 58 and 21% of all
control sites. There was a statistically significant difference between the test
and control sites for P.n. at baseline. The major difference after treatment with
25% metronidazole gel was the increase of positive control sites for P.g. and P.n.
However, there were no statistically significant differences in the occurrence rate
of A.a., P.g. and P.n. at test and control sites after treatment. This study has
shown that 25% metronidazole gel treatment did not seem to influence the microbial
outcome, when PCR was used to analyse the presence/absence of A.a., P.g. and P.n.
in this group of subjects with recurrent periodontal disease.
AN - rayyan-563560858
AU - Jansson, H.
AU - Hamberg, K.
AU - Söderholm, G.
AU - Bratthall, G.
IS - 2
metronidazole
adult
article
bacterial count
clinical trial
controlled study
female
human
male
microbiology
middle aged
periodontal disease
recurrent disease
treatment outcome
LA - English
PY - 2004
SN - 0347-9994
SP - 67-76
ST - The microbial outcome observed with polymerase chain reaction in subjects
with recurrent periodontal disease following local treatment with 25% metronidazole
gel
T2 - Swed Dent J
TI - The microbial outcome observed with polymerase chain reaction in subjects
with recurrent periodontal disease following local treatment with 25% metronidazole
gel
VL - 28
ID - 14232
ER -
TY - JOUR
AB - • Objective: This single-blind, five parallel-arm, four-week randomized
clinical trial was designed to compare the efficacy of a 0.05% cetylpyridinium
chloride gel-releasing interdental brush (IDB) with standard interproximal cleaning
devices for plaque and gingivitis reduction, and decreased frequency in
interproximal gingival bleeding. • Methodology: After consenting, participants
meeting inclusion criteria brushed their teeth, received a baseline examination and
a professional cleaning, and were then block-randomized into five groups, with the
plaque level serving as the blocking variable. All five groups performed standard
tooth brushing as a background regimen. Three of the groups were respectively
assigned to one of three interdental brush regimens, the fourth group was assigned
to a standard flossing regimen (positive control), and the fifth group was assigned
to a standard tooth brushing only regimen (control). Clinical outcome data were
collected at two and four weeks. • Results: Of a total of 162 starting
participants, 152 completed the study. There were no baseline differences among the
five groups with respect to age, interproximal plaque score, interproximal
gingivitis score, or percent of interproximal bleeding on probing. After two and
four weeks, the 3 IDB groups exhibited 30-40 percent lower plaque levels than the
control (p < 0.05). With respect to interproximal gingival scores, the active agent
IDB group exhibited a statistically significant effect after two weeks, and all
three IDB groups demonstrated significantly better outcomes after four weeks (p <
0.05). At two and four weeks, the three IDB groups demonstrated a greater reduction
in interproximal bleeding points upon probing compared to the two control groups (p
< 0.05). The group using the 0.05% cetylpyridinium gel-releasing IDB system did not
demonstrate superior clinical results when compared to the two other IDB groups. •
Conclusion: When compared to control and positive control interdental cleaning
procedures, daily use of IDBs was effective in reducing interproximal plaque and
gingivitis scores, as well as interproximal bleeding on probing. The benefits were
evident at two weeks, but were more consistent after four weeks. The 0.05%
cetylpyridinium gel-releasing IDB system did not appear to confer a consistently
independent incremental benefit.
AN - rayyan-563560781
AU - Jared, H.
AU - Zhong, Y.
AU - Rowe, M.
AU - Ebisutani, K.
AU - Tanaka, T.
AU - Takase, N.
IS - 2
placebo
adult
article
biofilm
clinical trial
comparative study
controlled study
dental device
equipment design
female
follow up
gel
gingiva bleeding
gingivitis
human
devices
male
periodontics
tooth brushing
tooth plaque
LA - English
PY - 2005
SN - 0895-8831
SP - 47-52
ST - Clinical trial of a novel interdental brush cleaning system
T2 - J. Clin. Dent.
TI - Clinical trial of a novel interdental brush cleaning system
VL - 16
ID - 14155
ER -
TY - JOUR
AB - Objective: To evaluate a 2% w/w minocycline gel (Dentomycin) in the treatment
of older adults with chronic periodontitis. Design: Vehicle-controlled, split-mouth
Setting: Dental Institute, St Bartholomew's and the Royal London School of Medicine
and Dentistry. Subjects: 22 adults (mean age 60 years). Interventions: At baseline,
patients received scaling and root planing. Test and placebo were applied at
contralateral disease sites surrounding 22 test and 22 control teeth at baseline,
and at weeks 2 and 4. Main outcome measure: Probing pocket depth, bleeding on
probing and supragingival plaque measurements, and microbiological sampling, at one
pocket site per tooth were undertaken at baseline, and at weeks 2,4,6 and 16.
Results: Microbial counts of Porphyromonas gingivalis, Prevotella intermedia and
Eikenella corrodens did not change significantly over 16 weeks. No significant
reductions in bleeding on probing and supragingival plaque score occurred with
either gel. A larger reduction in mean pocket depth, from baseline to week 16, was
found at test (6.50 to 4.95 mm; 24% reduction; P < 0.01) than at control sites
(6.41 to 5.33 mm; 14% reduction; P < 0.05). Conclusions: Minocycline gel
administration is a useful adjunct to scaling and root planing in the treatment of
older adults with periodontitis.
AN - rayyan-563561040
AU - Jarrold, C. R.
AU - Allaker, R. P.
AU - Young, K. A.
AU - Heath, M. R.
AU - Hardie, J. M.
AU - Lynch, E.
IS - 2
minocycline
aged
article
clinical trial
controlled study
epidemiology
female
human
male
microbiology
middle aged
periodontitis
tooth plaque
LA - English
PY - 1997
SN - 0007-0610
SP - 51-56
ST - Clinical and microbiological effects of topical minocycline in the treatment
of elderly patients with periodontitis
T2 - Brit. Dent. J.
TI - Clinical and microbiological effects of topical minocycline in the treatment
of elderly patients with periodontitis
VL - 183
ID - 14414
ER -
TY - JOUR
AB - During the last two decades, new drug delivery strategies have been invented
that have been able to solve microbial resistance against antibiotics. The goal of
the current report was to assess the antimicrobial effects of nano-catechin gels
against clinically isolated Porphyromonas gingivalis, one of the main causes of
periodontal disease. Catechin-loaded chitosan nanoparticles were prepared by adding
a catechin solution to a chitosan solution. Then, the mean particle size and the
mean surface charge (zeta potential) of the nanoparticles were detected through
photon correlation spectroscopy and zeta sizer, respectively. Nano-catechin gels
(1000, 500, 250, 125, 62.5, and 31.2 & mu;g/mL) were prepared, and the
antimicrobial assay was performed against clinically isolated Porphyromonas
gingivalis (P. gingivalis). The clinically obtained P. gingivalis isolates were
obtained from periodontitis patients (N = 15). The consequences are specified as
descriptive indices. The normality of data was detected by the Shapiro-Wilk test.
Then, to compare the data between groups (with a p value < 0.05 as the significance
level), SPSS software (version 22) was used via a Mann-Whitney U test. The results
showed a nanometer particle size range and a positive zeta potential for the
prepared nanoparticles. All the concentrations (1000, 500, 250, 125, 62.5, and 31.2
& mu;g/mL) of nano-catechin gels showed sustained release patterns and were non-
toxic against dental pulp stem cells as well. There were no significant differences
between the minimal inhibitory concentrations (MICs) for nano-catechin gel (test
group) and Chlorhexidine (control group) against 15 isolates (p > 0.05). Then, two
groups showed similar antimicrobial effects. The similar antimicrobial activity of
catechin nanoparticles and Chlorhexidine, as a potent antimicrobial agents, against
clinically isolated P. gingivalis showed that catechin nanoparticles can be used as
a potent antimicrobial material for the treatment of periodontal diseases in the
near future.
AN - rayyan-563562058
AU - Javadkhani, A.
AU - Shokouhi, B.
AU - Mosayebzadeh, A.
AU - Safa, S.
AU - Fahimi, M.
AU - Sharifi, S.
AU - Dizaj, S. M.
AU - Salatin, S.
DO - 10.3390/biomedicines11071932
IS - 7
PY - 2023
SN - 2227-9059
ST - Nano-Catechin Gel as a Sustained Release Antimicrobial Agent against
Clinically Isolated Porphyromonas gingivalis for Promising Treatment of Periodontal
Diseases
T2 - BIOMEDICINES
TI - Nano-Catechin Gel as a Sustained Release Antimicrobial Agent against
Diseases
VL - 11
Y2 - 7
ID - 15432
ER -
TY - JOUR
AB - During the last two decades, new drug delivery strategies have been invented
that have been able to solve microbial resistance against antibiotics. The goal of
the current report was to assess the antimicrobial effects of nano-catechin gels
against clinically isolated Porphyromonas gingivalis, one of the main causes of
periodontal disease. Catechin-loaded chitosan nanoparticles were prepared by adding
a catechin solution to a chitosan solution. Then, the mean particle size and the
mean surface charge (zeta potential) of the nanoparticles were detected through
photon correlation spectroscopy and zeta sizer, respectively. Nano-catechin gels
(1000, 500, 250, 125, 62.5, and 31.2 µg/mL) were prepared, and the antimicrobial
assay was performed against clinically isolated Porphyromonas gingivalis (P.
gingivalis). The clinically obtained P. gingivalis isolates were obtained from
periodontitis patients (N = 15). The consequences are specified as descriptive
indices. The normality of data was detected by the Shapiro-Wilk test. Then, to
compare the data between groups (with a p value < 0.05 as the significance level),
SPSS software (version 22) was used via a Mann-Whitney U test. The results showed a
nanometer particle size range and a positive zeta potential for the prepared
nanoparticles. All the concentrations (1000, 500, 250, 125, 62.5, and 31.2 µg/mL)
of nano-catechin gels showed sustained release patterns and were non-toxic against
dental pulp stem cells as well. There were no significant differences between the
minimal inhibitory concentrations (MICs) for nano-catechin gel (test group) and
Chlorhexidine (control group) against 15 isolates (p > 0.05). Then, two groups
showed similar antimicrobial effects. The similar antimicrobial activity of
catechin nanoparticles and Chlorhexidine, as a potent antimicrobial agents, against
clinically isolated P. gingivalis showed that catechin nanoparticles can be used as
a potent antimicrobial material for the treatment of periodontal diseases in the
near future.
AN - rayyan-563561120
AU - Javadkhani, A.
AU - Shokouhi, B.
AU - Mosayebzadeh, A.
AU - Safa, S.
AU - Fahimi, M.
AU - Sharifi, S.
AU - Salatin, S.
DO - 10.3390/biomedicines11071932
IS - 7
J2 - Biomedicines
LA - eng
N1 - Dental and Periodontal Research Center, Tabriz University of Medical
Sciences, Tabriz 51548-53431, Iran.; Dental and Periodontal Research Center, Tabriz
University of Medical Sciences, Tabriz 51548-53431, Iran.; Department of Dental
Biomaterials, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz
51548-53431, Iran.; Department of Dental Biomaterials, Faculty of Dentistry, Tabriz
University of Medical Sciences, Tabriz 51548-53431, Iran.; Department of Dental
Biomaterials, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz
51548-53431, Iran.; Dental and Periodontal Research Center, Tabriz University of
Medical Sciences, Tabriz 51548-53431, Iran.; Dental and Periodontal Research
Center, Tabriz University of Medical Sciences, Tabriz 51548-53431, Iran.;
Department of Dental Biomaterials, Faculty of Dentistry, Tabriz University of
Medical Sciences, Tabriz 51548-53431, Iran.; Neurosciences Research Center, Tabriz
University of Medical Sciences, Tabriz 51548-53431, Iran.
PY - 2023
SN - 2227-9059 (Print)
ST - Nano-Catechin Gel as a Sustained Release Antimicrobial Agent against
Diseases
T2 - Biomedicines
TI - Nano-Catechin Gel as a Sustained Release Antimicrobial Agent against
Diseases
VL - 11
Y2 - 7 y3 - 7
ID - 14494
ER -
TY - JOUR
AB - BACKGROUND: Local delivery of antimicrobial has resulted in good clinical
outcome along with scaling and root planing. The present study is carried out to
evaluate and compare the efficacy of local delivery of 10% doxycycline hyclate in
adjunct to scaling and root planing in the treatment of periodontitis. MATERIALS
AND METHODS: A randomized crossover split mouth design was performed, a total
number of 130 sites from 4 patients, 63 sites from patients with aggressive
periodontitis and 67 sites from chronic periodontitis patients were selected and
divided into scaling and root planing (SRP) group, SRP and doxycycline group and
doxycycline alone group. Clinical parameters viz. plaque index, modified gingival
index, bleeding index, clinical attachment level (CAL), and sub gingival
temperature were evaluated on day 0, 15(th), 45(th), and 90(th) day. CAL recording
was performed only on day 0 and 90(th) day. RESULTS: In 90 days study, all the
three groups showed significant reduction in clinical parameters. But on
comparison, SRP and doxycycline group showed better results than doxycycline alone
group and SRP alone group. CONCLUSION: The results of this study demonstrated that
doxycycline hyclate 10% gel (Atridox) is as effective as SRP in reducing the
clinical signs of periodontitis.
AN - rayyan-563561274
AU - Javali, M. A.
AU - Vandana, K. L.
DO - 10.4103/0972-124X.94603
IS - 1
LA - eng
N1 - Department of Periodontics, Al Badar Rural Dental College and Hospital,
Gulbarga, Karnataka, India.
PY - 2012
SP - 43-8
ST - A comparative evaluation of atrigel delivery system (10% doxycycline hyclate)
Atridox with scaling and root planing and combination therapy in treatment of
periodontitis: A clinical study
TI - A comparative evaluation of atrigel delivery system (10% doxycycline hyclate)
Atridox with scaling and root planing and combination therapy in treatment of
periodontitis: A clinical study
VL - 16
Y2 - 1
ID - 14648
ER -
TY - JOUR
AB - 1 Thrombin is activated during gingival tissue injury and inflammation.
Thrombin (platelet)-rich plasma has been used for periodontal regeneration with
success. Thrombin and other bacterial proteases also affect the functions of
adjacent periodontal cells via stimulation of protease-activated receptors (PARs).
2 We noted that thrombin (0.1-2 U ml-1), human, and frog PAR-1 agonist peptide (20-
240 μM) induced the gingival fibroblast (GF)-populated collagen gel contraction
within 2 h of exposure. However, PAR-2, PAR-3, and PAR-4 agonist peptide (20-240
μM) showed little effect on collagen gel contraction. U73122 (phospholipase C
inhibitor) and 2-APB (IP3 antagonist) were effective in inhibition of GF
contraction. 3 Thrombin-induced GF contraction was inhibited by 5 mM EGTA (an
extracellular calcium chelator) and verapamil (an L-type calcium channel blocker).
In addition, W7 (10 and 25 μM, a calcium/calmodulin (CaM) inhibitor), ML-7 (50 μM,
myosin light chain kinase (MLCK) inhibitor), and HA1077 (100 μM, Rho kinase
inhibitor) completely inhibited the thrombin-induced collagen gel contraction.
Thrombin also induced the phosphorylation of ERK1/ERK2 and elevated the Rho-GTP
levels in GF. 4 However, U0126 only partially inhibited the thrombin-induced GF
contraction. Similarly, wortmannin (100 nM), LY294002 (20 μM) (two PI3K inhibitor)
and genistein also showed partial inhibition. Moreover, NAC was not able to
suppress the GF contraction, as supported by the slight decrease in reactive oxygen
species production in GF by thrombin. 5 Thrombin also stimulated metalloproteinase-
2 (MMP-2) and MMP-3 production in GF. But addition of GM6001 or 1,10-
phenanthroline, two MMP inhibitors, could not inhibit the thrombin-induced GF
contraction. 6 These results indicate that thrombin is crucial in the periodontal
inflammation and wound healing by promoting GF contraction. This event is mainly
mediated via PAR-1 activation, PLC activation, extracellular calcium influx via L-
type calcium channel, and the calcium/CaM-MLCK and Rho kinase activation pathway. ©
2006 Nature Publishing Group All rights reserved.
AN - rayyan-563560778
AU - Jeng, J. H.
AU - Lan, W. H.
AU - Wang, J. S.
AU - Chan, C. P.
AU - Ho, Y. S.
AU - Lee, P. H.
AU - Wang, Y. J.
AU - Wang, T. M.
AU - Chen, Y. J.
AU - Chang, M. C.
DO - 10.1038/sj.bjp.0706462
IS - 2
KW - 1 (5 iodo 1 naphthalenesulfonyl)hexahydro 1h 1,4 diazepine
1 [[6 (3 methoxyestra 1,3,5(10) trien 17beta yl)amino]hexyl] 1h pyrrole 2,5 dione
1,10 phenanthroline
1,4 diamino 1,4 bis(2 aminophenylthio) 2,3 dicyanobutadiene
2 aminoethoxydiphenylborane
2 morpholino 8 phenylchromone
acetylcysteine
calcium antagonist
calcium channel blocking agent
calmodulin inhibitor
collagen gel
egtazic acid
fasudil
gelatinase A
genistein
ilomastat
metalloproteinase inhibitor
myosin light chain kinase inhibitor
n (6 aminohexyl) 5 chloro 1 naphthalenesulfonamide
phosphatidylinositol 3 kinase inhibitor
phospholipase C inhibitor
Rho kinase
Rho kinase inhibitor
stromelysin
thrombin
thrombin receptor activating peptide
thrombin receptor activating peptide 6
verapamil
wortmannin
article
calcium transport
cell population
controlled study
drug antagonism
drug effect
enzyme activation
enzyme synthesis
fibroblast
Anura
gingiva
human
human cell
normal human
periodontitis
priority journal
signal transduction
wound healing
gm 6001
ha 1077
ly 294002
ml 7
u 0126
u 73122
w 7
LA - English
PY - 2006
SN - ["0007-1188", "1476-5381"]
SP - 188-198
ST - Signaling mechanism of thrombin-induced gingival fibroblast-populated
collagen gel contraction
T2 - Br. J. Pharmacol.
TI - Signaling mechanism of thrombin-induced gingival fibroblast-populated
collagen gel contraction
VL - 147
ID - 14152
ER -
TY - JOUR
AB - Metronidazole (MD) is known as a periodontitis medicine and has been widely
used in antibiotics for resistance to anaerobic bacteria, periodontal disease, and
other threats. To treat diseases, drug delivery carriers are needed with a high
bioadhesive property and enhanced drug penetration. Poly (acrylic acid) (PAA)
hydrogel films have a good bioadhesive property and are able to localize the
absorption site and increase the drug residence time. In this study, we fabricated
a MD loaded PAA hydrogel with different MD content (0.1, 0.25, 0.5, and 1 wt%)
using varying doses (25, 50, and 75 kGy) and the radiation doses (25, 50, or 75
kGy) in a one-step gamma-ray irradiation process. The chemical and physical
structure were determined through a Fourier transformed infrared spectroscopy, X-
ray photoelectron spectroscopy, gel content, and compressive strength. In addition,
MD loaded PAA hydrogels were performed to MD release behaviors and cytotoxicity.
Finally, we conducted antibacterial activity to demonstrate the prevention of
growth of bacteria as a therapeutic dressing. The basic chemical structure analysis
of MD was changed greatly at radiation doses of 50 and 75 kGy due to degradation by
gamma-ray irradiation. However, when the absorbed dose was 25 kGy, the chemical
structure analysis of MD did not change significantly, and the gel content and
compressive strength of MD/PAA hydrogel were approximately 80% and 130 kPa,
respectively. The MD/PAA hydrogels exhibited no cytotoxicity and good antibacterial
activity against Escherichia coli, Staphylococcus aureus, and Streptococcus mutans.
These results provide good evidence that MD/PAA hydrogel prepared by gamma-ray
irradiation has potential as a competitive candidate for the therapeutic dressing.
AN - rayyan-563561136
AU - Jeong, J. O.
AU - Park, J. S.
AU - Kim, E. J.
AU - Jeong, S. I.
AU - Lee, J. Y.
AU - Lim, Y. M.
DO - 10.3390/ijms21010187
IS - 1
J2 - Int J Mol Sci
KW - Acrylic Resins/*chemistry
Anti-Bacterial Agents/chemistry/*pharmacology
Drug Delivery Systems
Escherichia coli/drug effects
Gamma Rays
Hydrogels
Metronidazole/chemistry/*pharmacology
Molecular Structure
Staphylococcus aureus/drug effects
LA - eng
N1 - Advanced Radiation Technology Institute, Korea Atomic Energy Research
Institute, Jeongup-si, Jeollabuk-do 56212, Korea.; School of Materials Science and
Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.;
Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute,
Jeongup-si, Jeollabuk-do 56212, Korea.; Internal Medicine, Mary's Hospital, College
of Medicine, The Catholic University, Uijeongbu-si, Gyeonggi-do 11765, Korea.;
Jeongup-si, Jeollabuk-do 56212, Korea.; School of Materials Science and
Engineering, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.;
Jeongup-si, Jeollabuk-do 56212, Korea.
PY - 2019
ST - Preparation of Radiation Cross-Linked Poly(Acrylic Acid) Hydrogel Containing
Metronidazole with Enhanced Antibacterial Activity
T2 - International journal of molecular sciences
TI - Preparation of Radiation Cross-Linked Poly(Acrylic Acid) Hydrogel Containing
Metronidazole with Enhanced Antibacterial Activity
VL - 21
Y2 - 12 y3 - 26
ID - 14510
ER -
TY - JOUR
AB - Metronidazole (MD) is known as a periodontitis medicine and has been widely
used in antibiotics for resistance to anaerobic bacteria, periodontal disease, and
other threats. To treat diseases, drug delivery carriers are needed with a high
bioadhesive property and enhanced drug penetration. Poly (acrylic acid) (PAA)
hydrogel films have a good bioadhesive property and are able to localize the
absorption site and increase the drug residence time. In this study, we fabricated
a MD loaded PAA hydrogel with different MD content (0.1, 0.25, 0.5, and 1 wt%)
using varying doses (25, 50, and 75 kGy) and the radiation doses (25, 50, or 75
kGy) in a one-step gamma-ray irradiation process. The chemical and physical
structure were determined through a Fourier transformed infrared spectroscopy, X-
ray photoelectron spectroscopy, gel content, and compressive strength. In addition,
MD loaded PAA hydrogels were performed to MD release behaviors and cytotoxicity.
Finally, we conducted antibacterial activity to demonstrate the prevention of
growth of bacteria as a therapeutic dressing. The basic chemical structure analysis
of MD was changed greatly at radiation doses of 50 and 75 kGy due to degradation by
gamma-ray irradiation. However, when the absorbed dose was 25 kGy, the chemical
structure analysis of MD did not change significantly, and the gel content and
compressive strength of MD/PAA hydrogel were approximately 80% and 130 kPa,
respectively. The MD/PAA hydrogels exhibited no cytotoxicity and good antibacterial
activity against Escherichia coli, Staphylococcus aureus, and Streptococcus mutans.
These results provide good evidence that MD/PAA hydrogel prepared by gamma-ray
irradiation has potential as a competitive candidate for the therapeutic dressing.
AN - rayyan-563560140
AU - Jeong, J. O.
AU - Park, J. S.
AU - Kim, E. J.
AU - Jeong, S. I.
AU - Lee, J. Y.
AU - Lim, Y. M.
DO - 10.3390/ijms21010187
IS - 1
metronidazole
article
biocompatibility
cell viability
chemical reaction kinetics
chemical structure
drug penetration
drug release
gamma radiation
hydrogel
interferon gamma release assay
particle size
photoelectron spectroscopy
radiation dose
radiation exposure
radiation scattering
retention time
structure analysis
surface property
tensile strength
thermogravimetry
X ray diffraction
zone of inhibition
LA - English
PY - 2020
SN - ["1422-0067", "1661-6596"]
ST - Preparation of radiation cross-linked poly(Acrylic acid) hydrogel containing
metronidazole with enhanced antibacterial activity
TI - Preparation of radiation cross-linked poly(Acrylic acid) hydrogel containing
metronidazole with enhanced antibacterial activity
VL - 21
ID - 13514
ER -
TY - JOUR
AB - The purpose of this study was to assess the clinical and microbiological
effects of a newly developed root conditioning gel system containing tetracycline
or a mixture of tetracycline and citric acid on non-surgical periodontal therapy.
Sixty-four (64) single-rooted teeth with a probing depth of 4 to 6 mm were randomly
subjected to one of the following four treatments; 1) root planing alone (RP
group); 2) tetracycline-containing gel alone (TCG group); 3) root planing plus
tetracycline-containing gel (RP+TCG group); or 4) root planing plus a mixture of
tetracycline and citric acid-containing gel (RP+TC-CAG group). Probing depth,
attachment level, and tooth mobility were measured and the presence of dental
plaque and gingival inflammation was recorded at baseline and after 2, 4, 8, and 12
weeks. Subgingival plaque samples from each site were collected at the same visits
and examined with phase contrast microscopy for proportions of motile rods and
spirochetes. Plaque index, gingival sulcus bleeding index (SBI), probing depth, and
attachment level decreased significantly in all groups compared to the baseline
values (P < 0.05). A signiftcant decrease in probing pocket depth was noted after
12 weeks in RP+TC-CAG group compared to the other groups (P < 0.05). Significantly
more gain in attachment was detected in the RP+TC-CAG group compared to the TCG
group (P < 0.05). Tooth mobility scores also decreased later in the study. A
significant decrease in the proportion of motile rods was found primarily in the
RP+TC-CAG group. There was a significant decrease of the proportion of spirochetes
in all groups. The results indicated that use of a mixture of tetracycline and
citric acid containing-gel was effective in improving gingival health and in
changing subgingival microflora.
AN - rayyan-563561077
AU - Jeong, S. N.
AU - Han, S. B.
AU - Lee, S. W.
AU - Magnusson, I.
DO - 10.1902/jop.1994.65.9.840
IS - 9
KW - citric acid
tetracycline
adult
article
clinical article
clinical trial
controlled study
drug mixture
female
gel
human
male
periodontal disease
periodontitis
LA - English
PY - 1994
SN - 0022-3492
SP - 840-847
ST - Effects of tetracycline-containing gel and a mixture of tetracycline and
TI - Effects of tetracycline-containing gel and a mixture of tetracycline and
VL - 65
ID - 14451
ER -
TY - JOUR
AB - PURPOSE: To analyze in vitro new formulations with Citrox and chlorhexidine
digluconate (CHX) regarding their antibacterial activity against planktonic
bacteria and their potential to inhibit biofilm formation or to act on existing
biofilms. MATERIALS AND METHODS: Five oral health care products with 0.05%-0.5% CHX
formulations (four rinses and one gel) were compared with Citrox preparations and
additive-free CHX solutions. The minimal inhibitory concentrations (MIC) were
determined against 13 oral bacteria associated with caries or periodontitis.
Further, the activity on retarding biofilm formation and on existing biofilms was
analyzed; both a 'cariogenic' (5 species) and a 'periodontal' (12 species) biofilm
were included. RESULTS: The MIC values did not differ between the CHX
mouthrinse/gel formulations and the respective additive-free CHX solutions. Citrox
was active against selected periodontopathogens (e.g. Porphyromonas gingivalis).
The CHX formulations more effectively retarded biofilm formation than did solutions
with the same concentration of CHX but without additives. The anti-biofilm
activities depended on the CHX concentration in the formulations. Both CHX
solutions and formulations (rinse and gel) were only slightly active on an already
formed biofilm. Citrox did not exert any anti-biofilm effect. CONCLUSION: The
present in vitro data support the anti-biofilm activity of the novel CHX, Citrox,
poly-L-lysine and xylitol oral health-care formulations. Further studies are
warranted to confirm the present findings in various clinical settings.
AN - rayyan-563560078
AU - Jeyakumar, J.
AU - Sculean, A.
AU - Eick, S.
DO - 10.3290/j.ohpd.a45437
IS - 1
KW - chlorhexidine
mouthwash
biofilm
health
LA - English
PY - 2020
SN - 1757-9996
SP - 981-990
ST - Anti-biofilm Activity of Oral Health-care Products Containing Chlorhexidine
Digluconate and Citrox
TI - Anti-biofilm Activity of Oral Health-care Products Containing Chlorhexidine
Digluconate and Citrox
VL - 18
ID - 13452
ER -
TY - JOUR
AB - A novel injectable thermosensitive hydrogel (CS-HTCC/α β-GP) was successfully
designed and prepared using chitosan (CS), quaternized chitosan (HTCC) and α,β-
glycerophosphate (α,β-GP) without any additional chemical stimulus. The gelation
point of CS-HTCC/α β-GP can be set at a temperature close to normal body
temperature or other temperature above 25°C. The transition process can be
controlled by adjusting the weight ratio of CS to HTCC, or different final
concentration of α,β-GP. The optimum formulation is (CS + HTCC) (2% w/v), CS/HTCC
(5/1 w/w) and α,β-GP 8.33% or 9.09% (w/v), where the sol-gel transition time was 3
min at 37°C. The drug released over 3 h from the CS-HTCC/α,β-GP thermosensitive
hydrogel in artificial saliva pH 6.8. In addition, CS-HTCC/α,β-GP thermosensitive
hydrogel exhibited stronger antibacterial activity towards two periodontal
pathogens (Porphyromonas gingivalis, P.g and Prevotella intermedia, P.i).
CS-HTCC/α, β-GP thermosensitive hydrogel was a considerable candidate as a local
drug delivery system for periodontal treatment. © 2009 Springer Science+Business
Media, LLC.
AN - rayyan-563560670
AU - Ji, Q. X.
AU - Chen, X. G.
AU - Zhao, Q. S.
AU - Liu, C. S.
AU - Cheng, X. J.
AU - Wang, L. C.
DO - 10.1007/s10856-009-3729-x
IS - 8
KW - alpha,beta glycerophosphate
chitosan
glycerophosphate
saliva substitute
unclassified drug
article
controlled study
drug release
gelation
heat sensitivity
hydrogel
in vitro study
nonhuman
pH measurement
priority journal
temperature measurement
LA - English
PY - 2009
SN - 0957-4530
SP - 1603-1610
ST - Injectable thermosensitive hydrogel based on chitosan and quaternized
chitosan and the biomedical properties
TI - Injectable thermosensitive hydrogel based on chitosan and quaternized
chitosan and the biomedical properties
VL - 20
ID - 14044
ER -
TY - JOUR
AB - PURPOSE: To evaluate the in vitro antibacterial activity of chitosan -
quaternized chitosan/alpha, beta-glycerophosphate (CS-HTCC/GP) thermosensitive
hydrogel against three periodontal pathogens- P. gingivalis, P. intermedia, and A.
actinomycetemcomitans. METHODS: An agar diffusion method was used to assess the
antimicrobial property of CS-HTCC/GP thermosensitive hydrogel with minimum
inhibitory concentration (MIC) and inhibitory zone measurement. SPSS13.0 software
package was used for Student's t test. RESULTS: Three periodontal pathogens strains
were all susceptible to CS-HTCC/GP thermosensitive hydrogel. Both matrix of
thermosensitive hydrogel and antibiotic exhibited stronger antibacterial activity
especially when they were combined. CONCLUSIONS: CS-HTCC/GP thermosensitive
hydrogel is not only as the vehicle of antibiotics which joins the local drug
delivery system but as an activator which takes part in the antibacterial process.
AN - rayyan-563561398
AU - Ji, Q. X.
AU - Deng, J.
AU - Yu, X. B.
AU - Xu, Q. C.
AU - Xu, X. Y.
IS - 4
J2 - Shanghai Kou Qiang Yi Xue
KW - Anti-Bacterial Agents
Anti-Infective Agents
*Chitosan
Glycerophosphates
*Hydrogel, Polyethylene Glycol Dimethacrylate
In Vitro Techniques
Temperature
LA - chi
N1 - Department of Stomatology, The Affiliated Hospital of Qingdao University
Medical College, Qingdao 266003, Shandong Province, China. jqx_1@163.com
PY - 2009
SN - 1006-7248 (Print)
SP - 397-400
ST - [An in vitro evaluation of the antibacterial activity of chitosan-based
thermosensitive hydrogel against periodontal pathogens]
T2 - Shanghai kou qiang yi xue = Shanghai journal of stomatology
TI - [An in vitro evaluation of the antibacterial activity of chitosan-based
thermosensitive hydrogel against periodontal pathogens]
VL - 18
Y2 - 8
ID - 14772
ER -
TY - JOUR
AB - The aim of this paper was to evaluate the application potential of
CS-HTCC/GP-0.1%Chx thermosensitive hydrogel which was synthesized using chitosan
(CS), quaternized CS, and α,β-glycerophosphate (α,β-GP) loading with 0.1%
chlorhexidine (Chx) (w/v) for periodontal treatment. An aqueous solution of CS-
HTCC/GP-0.1%Chx was transformed into hydrogel at 6 min when the temperature was
increased to 37°C. The scan electron microscopy (SEM) image of the gel was a
porous, loose and crosslinked network. In vitro, Chx released over 18 h from the
CS-HTCC/GP thermosensitive hydrogel in artificial saliva pH 6.8. Release rate could
be controlled through adjustment of α,β-GP or Chx concentration. CS-HTCC/GP-0.1%Chx
thermosensitive hydrogel exhibited excellent inhibitory activity against primary
periodontal pathogens. CS-HTCC/GP-0.1%Chx thermosensitive hydrogel had no acute
toxicity; the maximum tolerated dose in rats was 400 mg/ml. All results indicated
that CS-HTCC/GP-0.1%Chx thermosensitive hydrogel is a strong candidate as a local
drug delivery system for periodontal treatment. © 2010 Springer Science+Business
Media, LLC.
AN - rayyan-563560632
AU - Ji, Q. X.
AU - Zhao, Q. S.
AU - Deng, J.
AU - Lü, R.
DO - 10.1007/s10856-010-4098-1
IS - 8
KW - alpha,beta glycerophosphate
chitosan
chlorhexidine
glycerophosphate
saliva substitute
unclassified drug
acidity
aqueous solution
article
cross linking
drug synthesis
female
heat sensitivity
hydrogel
in vitro study
inhibition kinetics
male
mouse
nonhuman
periodontics
priority journal
rat
toxicity testing
LA - English
PY - 2010
SN - 0957-4530
SP - 2435-2442
ST - A novel injectable chlorhexidine thermosensitive hydrogel for periodontal
application: Preparation, antibacterial activity and toxicity evaluation
TI - A novel injectable chlorhexidine thermosensitive hydrogel for periodontal
application: Preparation, antibacterial activity and toxicity evaluation
VL - 21
ID - 14006
ER -
TY - JOUR
AB - The aim of this paper was to evaluate the application potential of
CS-HTCC/GP-0.1%Chx thermosensitive hydrogel which was synthesized using chitosan
(CS), quaternized CS, and alpha,beta-glycerophosphate (alpha,beta-GP) loading with
0.1% chlorhexidine (Chx) (w/v) for periodontal treatment. An aqueous solution of
CS-HTCC/GP-0.1%Chx was transformed into hydrogel at 6 min when the temperature was
increased to 37A degrees C. The scan electron microscopy (SEM) image of the gel was
a porous, loose and crosslinked network. In vitro, Chx released over 18 h from the
CS-HTCC/GP thermosensitive hydrogel in artificial saliva pH 6.8. Release rate could
be controlled through adjustment of alpha,beta-GP or Chx concentration. CS-HTCC/GP-
0.1%Chx thermosensitive hydrogel exhibited excellent inhibitory activity against
primary periodontal pathogens. CS-HTCC/GP-0.1%Chx thermosensitive hydrogel had no
acute toxicity; the maximum tolerated dose in rats was 400 mg/ml. All results
indicated that CS-HTCC/GP-0.1%Chx thermosensitive hydrogel is a strong candidate as
a local drug delivery system for periodontal treatment.
AN - rayyan-563562169
AU - Ji, Q. X.
AU - Zhao, Q. S.
AU - Deng, J.
AU - Lu, R.
DO - 10.1007/s10856-010-4098-1
IS - 8
PY - 2010
SN - ["0957-4530", "1573-4838"]
SP - 2435-2442
ST - A novel injectable chlorhexidine thermosensitive hydrogel for periodontal
application: preparation, antibacterial activity and toxicity evaluation
TI - A novel injectable chlorhexidine thermosensitive hydrogel for periodontal
application: preparation, antibacterial activity and toxicity evaluation
VL - 21
Y2 - 8
ID - 15543
ER -
TY - JOUR
AB - PURPOSE: To evaluate the in vitro antibacterial activity of chitosan -
quaternized chitosan/alpha, beta-glycerophosphate (CS-HTCC/GP) thermosensitive
hydrogel against three periodontal pathogens- P. gingivalis, P. intermedia, and A.
actinomycetemcomitans. METHODS: An agar diffusion method was used to assess the
antimicrobial property of CS-HTCC/GP thermosensitive hydrogel with minimum
inhibitory concentration (MIC) and inhibitory zone measurement. SPSS13.0 software
package was used for Student's t test. RESULTS: Three periodontal pathogens strains
were all susceptible to CS-HTCC/GP thermosensitive hydrogel. Both matrix of
thermosensitive hydrogel and antibiotic exhibited stronger antibacterial activity
especially when they were combined. CONCLUSIONS: CS-HTCC/GP thermosensitive
hydrogel is not only as the vehicle of antibiotics which joins the local drug
delivery system but as an activator which takes part in the antibacterial process.
AN - rayyan-563560671
AU - Ji, Q.
AU - Deng, J.
AU - Yu, X.
AU - Xu, Q.
AU - Xu, X.
IS - 4
chitosan
glycerophosphate
hydrogel
in vitro study
temperature
LA - Chinese
PY - 2009
SN - 1006-7248
SP - 397-400
ST - An in vitro evaluation of the antibacterial activity of chitosan-based
thermosensitive hydrogel against periodontal pathogens
T2 - Shanghai Kou Qiang Yi Xue
TI - An in vitro evaluation of the antibacterial activity of chitosan-based
thermosensitive hydrogel against periodontal pathogens
VL - 18
ID - 14045
ER -
TY - JOUR
AB - The study aimed to identify the key active components in Silybum marianum (S.
marianum) and determine how they protect against nonalcoholic fatty liver disease
(NAFLD). TCMSP, DisGeNET, UniProt databases, and Venny 2.1 software were used to
identify 11 primary active components, 92 candidate gene targets, and 30 core
hepatoprotective gene targets in this investigation, respectively. The PPI network
was built using a string database and Cytoscape 3.7.2. The KEGG pathway and GO
biological process enrichment, biological annotation, as well as the identified
hepatoprotective core gene targets were analyzed using the Metascape database. The
effect of silymarin on NAFLD was determined using H&E on pathological alterations
in liver tissues. The levels of liver function were assessed using biochemical
tests. Western blot experiments were used to observe the proteins that were
expressed in the associated signaling pathways on the hepatoprotective effect,
which the previous network pharmacology predicted. According to the KEGG enrichment
study, there are 35 hepatoprotective signaling pathways. GO enrichment analysis
revealed that 61 biological processes related to the hepatoprotective effect of S.
marianum were identified, which mainly involved in response to regulation of
biological process and immune system process. Silymarin was the major ingredient
derived from S. marianum, which exhibited the hepatoprotective effect by reducing
the levels of ALT, AST, TC, TG, HDL-C, LDL-C, decreasing protein expressions of IL-
6, MAPK1, Caspase 3, p53, VEGFA, increasing protein expression of AKT1. The present
study provided new sights and a possible explanation for the molecular mechanisms
of S. marianum against NAFLD.
AN - rayyan-563559907
AU - Jiang, G.
AU - Sun, C.
AU - Wang, X.
AU - Mei, J.
AU - Li, C.
AU - Zhan, H.
AU - Liao, Y.
AU - Zhu, Y.
AU - Mao, J.
DO - 10.1080/21655979.2022.2037374
IS - 3
KW - automatic biochemistry analyzer
clinical chemistry analyzer
microscope
taxifolin
24 methylidenelophenol
4-methylidenelophenol
ABC transporter A1
acetyl coenzyme A carboxylase 1
Activator of 90 kDa heat shock protein ATPase homolog
aldehyde dehydrogenase isoenzyme 2
Aldo-keto reductase family 1 member B1
alpha tocopherol
androgen receptor
arachidonate 5 lipoxygenase
arachidonic acid
aromatic hydrocarbon receptor
aryldialkylphosphatase 1
ATP-binding cassette sub-family G member 1
beta 2 adrenergic receptor
beta galactosidase
C reactive protein
caspase 3
caspase 8
Cathepsin D isoform 2
caveolin
cholesterol
cholesterol ester transfer protein
collagen type I alpha 1 chain
Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex
constitutive androstane receptor
copper zinc superoxide dismutase
cytochrome P450 1A1
cytochrome P450 1A2
cytochrome P450 3A4
dipeptidyl peptidase IV
dual oxidase 2
endoplasmic reticulum chaperone BiP
endothelial nitric oxide synthase
eosin
gamma interferon
gelatinase A
gelatinase B
glutathione transferase M1
glutathione transferase P1
heat shock protein 90 alpha
hematoxylin
heme oxygenase 1
high density lipoprotein cholesterol
hypoxia inducible factor 1
insulin receptor
interleukin 10
interleukin 1alpha
interleukin 1beta
interleukin 2
interleukin 6
interleukin 8
liver protective agent
liver protein
low density lipoprotein cholesterol
Mineralocorticoid receptor 3
Mitochondrial uncoupling protein 2
mitogen activated protein kinase 1
muscarinic receptor
Myc protein
myeloperoxidase
NADPH dehydrogenase [quinone] 1
Neutrophil cytosol factor 1
noradrenalin transporter
nuclear receptor coactivator 2
Orphan nuclear receptor PXR
osteopontin
peroxisome proliferator activated receptor
peroxisome proliferator activated receptor gamma
plant medicinal product
Poly polymerase
propylthiouracil
prostaglandin synthase 1
protein Bax
protein bcl 2
protein c fos
protein kinase C
protein kinase C beta
protein p53
quercetin
RAC-alpha serine/threonine- protein kinase
selenoprotein P
serine proteinase inhibitor
serotonin 2A receptor
silandrin
silibinin
silidianin
Silybum marianum extract
silymarin
silymonin
somatomedin B
STAT1 protein
stigmasterol
sulfotransferase
synaptotagmin I
transcription factor AP 1
triacylglycerol
tumor necrosis factor receptor superfamily member 1A
Tumor necrosis factor receptor superfamily member 1B
unclassified drug
vascular cell adhesion molecule 1
vasculotropin A
animal experiment
animal model
animal tissue
antifungal activity
apoptosis
article
blood biochemistry
body weight change
cell damage
controlled study
disordered hepatocytes
drug megadose
experimental test
gene ontology
ginger root powder
histopathology
KEGG
liver cell
liver function
liver protection
liver tissue
low drug dose
male
molecular docking
mouse
nonalcoholic fatty liver
nonhuman
nuclei damage
nutrient solution
pathway enrichment analysis
plant product
protein expression
signal transduction
Silybum marianum
systems pharmacology
total cholesterol level
Western blotting
LA - English
PY - 2022
SN - ["2165-5987", "2165-5979"]
SP - 5216-5235
ST - Hepatoprotective mechanism of Silybum marianum on nonalcoholic fatty liver
disease based on network pharmacology and experimental verification
T2 - Bioengineered
TI - Hepatoprotective mechanism of Silybum marianum on nonalcoholic fatty liver
disease based on network pharmacology and experimental verification
VL - 13
ID - 13281
ER -
TY - JOUR
AB - Due to their superior antibacterial properties, biocompatibility and high
conductivity, nanomaterials have shown a broad prospect in the biomedical field and
have been widely used in the prevention and treatment of oral diseases. Also due to
their small particle sizes and biodegradability, nanomaterials can provide
solutions for tissue engineering, especially for oral tissue rehabilitation and
regeneration. At present, research on nanomaterials in the field of dentistry
focuses on the biological effects of various types of nanomaterials on different
oral diseases and tissue engineering applications. In the current review, we have
summarized the biological effects of nanoparticles on oral diseases, their
potential action mechanisms and influencing factors. We have focused on the
opportunities and challenges to various nanomaterial therapy strategies, with
specific emphasis on overcoming the challenges through the development of
biocompatible and smart nanomaterials. This review will provide references for
potential clinical applications of novel nanomaterials in the field of oral
medicine for the prevention, diagnosis and treatment of oral diseases.
AN - rayyan-563559688
AU - Jiang, T.
AU - Su, W.
AU - Li, Y.
AU - Jiang, M.
AU - Zhang, Y.
AU - Xian, C. J.
AU - Zhai, Y.
DO - 10.3390/jfb14080404
IS - 8
KW - CT scanner
calcium carbonate
calcium fluoride
cell surface receptor
hydrogel
liposome
magnesium ion
nanofiber
nanomaterial
nanoparticle
nucleic acid
polyethylene
zinc oxide
bacterial growth
bacterial membrane
biocompatibility
biodegradability
biological activity
blood vessel
Candida albicans
cell phagocytosis
chemical bond
chewing gum
covalent bond
degradation
demineralization
dentin
DNA replication
drug release
ecosystem
enamel
encapsulation
endocytosis
endosome
enzymatic degradation
Escherichia coli
gingivitis
glomerulus filtration
hemostasis
human
implant infection
kidney
liver
lymphatic system
macrophage
materials science
mental health
mouth
mouth disease
mucosal disease
Mycoplasma
nanomedicine
nonhuman
oropharynx
oropharynx cancer
periodontal disease
periodontitis
phagocyte
phospholipid bilayer
physical appearance
physiology
pulpitis
regeneration
reticuloendothelial system
review
sensation
speech
spleen
stomatology
swallowing
target cell
tissue engineering
tooth extraction
urine
LA - English
PY - 2023
SN - 2079-4983
ST - Research Progress on Nanomaterials for Tissue Engineering in Oral Diseases
T2 - J. Funct. Biomater.
TI - Research Progress on Nanomaterials for Tissue Engineering in Oral Diseases
VL - 14
ID - 13062
ER -
TY - JOUR
AB - OBJECTIVE: To observe the effect of Doxycycline slow-release on periodontitis
therapy. METHODS:30 patients with chronic periodontitis were chosen and divided
into 2 groups randomly,these cases were given Doxycycline slow-release and
Zinciodati Comp solution. PLI,GI,SBI,PD,AL,MD and clinical symptoms were observed
before and after taking drug. RESULTS:The indose of PLI,GI,SBI,PD,AL,MD were
decreased significantly after the use of Doxycycline slow-release gel (P<0.05),the
effects of the Doxycycline was better than Zinciodati Comp solution (P<0.01), no
adverse drug side effects were found during trial. CONCLUSION:The use of
Doxycycline slow-release gel is one of the safe and effective chemotherapy on
periodontitis.
AN - rayyan-563560881
AU - Jin, H. L.
AU - Hu, C. Z.
AU - Chen, J. G.
AU - Xiao, Z. G.
AU - Sun, D. H.
IS - 4
KW - doxycycline
adult
aged
article
clinical trial
controlled study
female
gel
human
male
middle aged
periodontitis
LA - Chinese
PY - 2003
SN - 1006-7248
SP - 250-252
ST - A clinical study of doxycycline slow-release gel on periodontitis
chemotherapy
TI - A clinical study of doxycycline slow-release gel on periodontitis
chemotherapy
VL - 12
ID - 14255
ER -
TY - JOUR
AB - PURPOSE: To evaluate the therapeutic effects of doxycycline nano-liposome
slow-release gel on the periodontitis in an established rat model. METHODS: The
biocompatibility was tested by oral perfusion sample gel for long term observation.
Doxycycline nano-gel was used to treat the established rat model of periodontitis.
The rats were selected randomly and divided into five groups: blank group,
doxycycline nano-gel treated group, minocycline-treated group, matrix group and
periodontitis model group. MMP-8 and TIMP-1 in the sulcus fluid were detected by
real-time PCR. The data was analysed using SAS13.3 software package for Student's t
test. RESULTS: Doxycycline nano-gel had excellent biocompatibility from weight
measure and tissue section evaluation. The results in periodontitis rats
demonstrated that doxycycline nano-gel could ameliorate periodontitis condition
dramatically compared with the control group, the restoration even better than
minocycline-treated group. CONCLUSIONS: Doxycycline nano-liposome slow-release gel
improves rat periodontitis by decreasing MMP-8 level, which provides valuable
evidence to promote doxycycline nano-gel clinical application.
AN - rayyan-563560629
AU - Jin, H.
AU - Wu, W.
AU - Shu, R.
IS - 5
KW - doxycycline
liposome
tissue inhibitor of metalloproteinase-1 protein, rat
animal
periodontitis
rat
LA - Chinese
PY - 2010
SN - 1006-7248
SP - 508-511
ST - Doxycycline nano-liposome slow-release gel improves rat periodontitis
TI - Doxycycline nano-liposome slow-release gel improves rat periodontitis
VL - 19
ID - 14003
ER -
TY - JOUR
AB - Genetic polymorphisms in the interleukin-6 (IL-6) gene are associated with
bone homeostasis and diseases characterized by bone loss. The aim of this study was
to investigate the correlation between the IL-6-572C/G polymorphism and the risk of
chronic periodontitis in a Chinese Han population. The IL-6-572C/G polymorphism was
genotyped in 93 patients suffering from chronic periodontitis and 96 control
subjects by polymerase chain reaction-restriction fragment length polymorphism. DNA
was extracted from the peripheral blood of patients and control subjects and
amplified using a polymerase chain reaction. IL-6 genotypes were identified using
gel electrophoresis. The IL-6-572 GG genotype and the G allele were more frequent
in chronic periodontitis patients than in control subjects (P<.05). When compared
with the CC genotype, the odds ratio for chronic periodontitis was 1.88 (95%
confidence interval, 1.04 to 3.40; P<.05) for the CG+GG genotype. The frequency of
the -572CG+GG genotype was significantly different between the control group and
the group with chronic periodontitis. Therefore, the IL-6-572C/G polymorphism may
contribute to the susceptibility to chronic periodontitis in the Chinese Han
population.
AN - rayyan-563560641
AU - Jingjin, L.
AU - Zemin, G.
AU - Xin, M.
AU - Donghong, W.
AU - Jianhua, G.
AU - Jie, Y.
AU - Yonggong, W.
IS - 3
KW - interleukin 6
adult
aged
allele
article
Asian
case control study
China
female
gene frequency
genetic predisposition
genetics
human
male
middle aged
restriction fragment length polymorphism
risk
LA - English
PY - 2010
SN - 0198-7569
SP - 301-305
ST - Correlation between an interleukin-6 -572C/G polymorphism and chronic
periodontitis
TI - Correlation between an interleukin-6 -572C/G polymorphism and chronic
periodontitis
VL - 30
ID - 14015
ER -
TY - JOUR
AB - Bioactive agents, including proteins and peptides, can be loaded into
hydrogels to improve bone regenerative capacity with their controlled release.
However, the current loading method has focused on physical mixing, which has
limited release control. Therefore, alternative conjugation of bioactive agents
with hydrogels is highly recommended. Direct chemical conjugation of synthetic
peptides containing a functional moiety with a hydrogel would be ideal. Here, we
synthesized a bioactive calcium accumulating peptide (CAP) containing a collagen
binding motif, which can induce osteogenic differentiation. A tyrosine residue in
CAP was used to directly chemically conjugate the peptide with a gelatin-based
enzymatically crosslinked hydroxyphenyl propionic acid hydrogel under H2O2/Horse
radish peroxidase conditions. To test the acceleration of bone formation, human
periodontal ligament stem cells (PDLSCs) were loaded into a chemically conjugated
CAP hydrogel. The CAP hydrogel induced bone mineralization around the PDLSCs and
increased osteogenic marker expressions in vitro. It also recovered a bone layer in
a calvarial defect 4 weeks postimplantation. In summary, an injectable CAP hydrogel
scaffold system was developed as a potentially useful engineered microenvironment
to enhance bone restoration, and it could be utilized as a vehicle for bioactive
delivery of stem cells in tissue regenerative therapy. © 2017 Wiley Periodicals,
Inc. J Biomed Mater Res Part A: 106A: 531–542, 2018.
AN - rayyan-563560264
AU - Jo, B. S.
AU - Lee, Y.
AU - Suh, J. S.
AU - Park, Y. S.
AU - Lee, H. J.
AU - Lee, J. Y.
AU - Cho, J.
AU - Lee, G.
AU - Chung, C. P.
AU - Park, K. D.
AU - Park, Y. J.
DO - 10.1002/jbm.a.36257
IS - 2
atrolactic acid
biomaterial
calcium
calcium accumulating peptide
collagen binding motif
collagen type 1
gelatin
hydrogen peroxide
messenger RNA
osteocalcin
peptide
Smad1 protein
Smad5 protein
Smad8 protein
synthetic peptide
tyrosine
unclassified drug
animal cell
animal experiment
article
bone mineralization
bone regeneration
cell proliferation
conjugation
controlled study
hydrogel
in vitro study
male
microenvironment
nonhuman
ossification
protein expression
rat
stem cell
LA - English
PY - 2018
SN - ["1552-4965", "1549-3296"]
SP - 531-542
ST - A novel calcium-accumulating peptide/gelatin in situ forming hydrogel for
enhanced bone regeneration
T2 - J. Biomed. Mater. Res. Part A
TI - A novel calcium-accumulating peptide/gelatin in situ forming hydrogel for
enhanced bone regeneration
VL - 106
ID - 13638
ER -
TY - JOUR
AB - Background: Previous studies showed that host modulation therapy (HMT) or
topical antimicrobial therapy (TAT) provided significant adjunctive benefits to
scaling and root planing (SRP) in the treatment of chronic periodontitis (CP). The
purpose of this study was to evaluate a combination therapy involving SRP, HMT, and
TAT in the treatment of moderate to severe CP. Methods: A 6-month, randomized,
multicenter, placebo-controlled, examiner-masked study was undertaken to evaluate
the clinical usefulness of a combination treatment of systemically delivered
doxycycline hyclate (HMT; 20 mg, twice a day) plus locally delivered doxycycline
hyclate gel (TAT; 10%, in pockets ≥5 mm) in combination with SRP versus SRP plus
placebo. Clinical outcomes included mean changes in probing depth (PD), clinical
attachment level (CAL), bleeding on probing (BOP), and gingival index (GI) at
baseline and at 3 and 6 months. Results: In 171 subjects, combination therapy
provided significantly greater clinical benefits than control therapy for all
clinical measures at 3 and 6 months. In moderate CP (PD of 4 to 6 mm), combination
therapy provided significant benefits over control for PD (3 and 6 months: P<0.01),
CAL (3 months: P<0.01; 6 months: P <0.03), BOP (3 months: P<0.02; 6 months:
P<0.05), and Gl (3 months: P<0.01; 6 months: P<0.03). In severe CP (PD ≥7 mm),
combination therapy provided significant benefits over control for PD (3 and 6
months: P<0.01), CAL (3 months: P<0.01; 6 months: P<0.02), BOP (3 months: P<0.01; 6
months: P>0.05), and GI (3 months: P<0.01; 6 months: P<0.01). Conclusion:
Combination therapy, including SRP, HMT, and TAT, provided significantly greater
clinical benefits than SRP alone in the treatment of moderate to severe CP.
AN - rayyan-563560727
AU - John Novak, M.
AU - Dawson Iii, D. R.
AU - Magnusson, I.
AU - Karpinia, K.
AU - Poison, A.
AU - Polson, A.
AU - Ryan, M. E.
AU - Ciancio, S.
AU - Drisko, C. H.
AU - Kinane, D.
AU - Powala, C.
AU - Bradshaw, M.
DO - 10.1902/jop.2008.070237
IS - 1
doxycycline
placebo
adolescent
adult
aged
article
chronic disease
clinical trial
controlled study
female
follow up
gingiva bleeding
human
male
middle aged
multicenter study
periodontal disease
periodontics
periodontitis
treatment outcome
LA - English
PY - 2008
SN - 0022-3492
SP - 33-41
ST - Combining host modulation and topical antimicrobial therapy in the management
of moderate to severe periodontitis: A randomized multicenter trial
TI - Combining host modulation and topical antimicrobial therapy in the management
VL - 79
ID - 14101
ER -
TY - JOUR
AB - Periodontitis is an inflammatory disease that can lead to the periodontal
pocket formation and tooth loss. This study was aimed to develop antimicrobials
loaded hydrogels composed of cellulose nanofibers (CNF) and kappa-carrageenan
oligosaccharides (CO) nanoparticles for the treatment of periodontitis. Two
antimicrobial agents such as surfactin and Herbmedotcin were selected as the
therapeutic agents and the hydrogels were formulated based on the increasing
concentration of surfactin. The proposed material has high thermal stability,
controlled release, and water absorption capacity. This study was proceeded by
investigating the in vitro antibacterial and anti-inflammatory properties of the
hydrogels. This material has strong antibacterial activity against periodontal
pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Fusobacterium
nucleatum, and Pseudomonas aeruginosa. Moreover, a significant increase in
malondialdehyde (MDA) production and a decrease in biofilm formation and metabolic
activity of the bacteria was observed in the presence of hydrogel. Besides, it
reduced the reactive oxygen species (ROS) generation, transcription factor, and
cytokines production in human gingival fibroblast cells (HGF) under inflammatory
conditions. In conclusion, the hydrogels were successfully developed and proven to
have antibacterial and anti-inflammatory properties for the treatment of
periodontitis. Thus, it can be used as an excellent candidate for periodontitis
treatment.
AN - rayyan-563562286
AU - Johnson, A.
AU - Kong, F. B.
AU - Miao, S.
AU - Lin, H. T. V.
AU - Thomas, S.
AU - Huang, Y. C.
AU - Kong, Z. L.
DO - 10.1038/s41598-020-74845-9
IS - 1
PY - 2020
SN - 2045-2322
ST - Therapeutic effects of antibiotics loaded cellulose nanofiber and kappa-
carrageenan oligosaccharide composite hydrogels for periodontitis treatment
T2 - SCIENTIFIC REPORTS
TI - Therapeutic effects of antibiotics loaded cellulose nanofiber and kappa-
VL - 10
Y2 - 10 y3 - 22
ID - 15660
ER -
TY - JOUR
loaded hydrogels composed of cellulose nanofibers (CNF) and κ-carrageenan
treatment.
AN - rayyan-563560079
AU - Johnson, A.
AU - Kong, F.
AU - Miao, S.
AU - Lin, H. T. V.
AU - Thomas, S.
AU - Huang, Y. C.
AU - Kong, Z. L.
DO - 10.1038/s41598-020-74845-9
IS - 1
carrageenan
cellulose
nanofiber
biofilm
chemistry
drug effect
fibroblast
gingiva
human
hydrogel
microbiology
pathology
periodontitis
LA - English
PY - 2020
SN - 2045-2322
SP - 18037
ST - Therapeutic effects of antibiotics loaded cellulose nanofiber and κ-
T2 - Sci Rep
TI - Therapeutic effects of antibiotics loaded cellulose nanofiber and κ-
VL - 10
ID - 13453
ER -
TY - JOUR
loaded hydrogels composed of cellulose nanofibers (CNF) and κ-carrageenan
treatment.
AN - rayyan-563561250
AU - Johnson, A.
AU - Kong, F.
AU - Miao, S.
AU - Lin, H. V.
AU - Thomas, S.
AU - Huang, Y. C.
AU - Kong, Z. L.
DO - 10.1038/s41598-020-74845-9
IS - 1
J2 - Sci Rep
KW - Anti-Bacterial Agents/chemistry/*pharmacology
Biofilms/*drug effects/growth & development
Carrageenan/*chemistry
Cellulose/*chemistry
Fibroblasts/drug effects/microbiology/pathology
Fusobacterium nucleatum/drug effects/isolation & purification
Gingiva/drug effects/microbiology/pathology
Humans
Hydrogels/*chemistry
Nanofibers/*chemistry
Periodontitis/*drug therapy/microbiology/pathology
Porphyromonas gingivalis/drug effects/isolation & purification
Streptococcus mutans/drug effects/isolation & purification
LA - eng
N1 - Department of Food Science, National Taiwan Ocean University, Pei-Ning Road,
Keelung, 20224, Taiwan, ROC.; Department of Food Science and Technology, University
of Georgia, 100 Cedar Street, Athens, GA, 30602, USA.; Teagasc Food Research
Centre, Moorepark, Fermoy, Co., Cork, P61 C996, Ireland.; Department of Food
Science, National Taiwan Ocean University, Pei-Ning Road, Keelung, 20224, Taiwan,
ROC.; School of Energy Studies and School of Chemical Sciences, Mahatma Gandhi
University, Priyadarshini Hills P.O, Kottayam, Kerala, 686560, India.; Department
of Food Science, National Taiwan Ocean University, Pei-Ning Road, Keelung, 20224,
Taiwan, ROC.; Department of Food Science, National Taiwan Ocean University, Pei-
Ning Road, Keelung, 20224, Taiwan, ROC. kongzl@mail.ntou.edu.tw.
PY - 2020
SP - 18037
ST - Therapeutic effects of antibiotics loaded cellulose nanofiber and κ-
T2 - Scientific reports
TI - Therapeutic effects of antibiotics loaded cellulose nanofiber and κ-
VL - 10
Y2 - 10 y3 - 22
ID - 14624
ER -
TY - JOUR
AB - This article reviews the studies that provided the safety and efficacy data
essential for the Food and Drug Administration approval of Atridox. These studies
detail the clinical effectiveness of Atridox and provide the foundation for an
understanding of the use of Atridox in the clinical management of patients with
periodontitis. Atridox is a locally delivered, controlled-release system for the
administration of high concentrations of doxycycline to the periodontal pocket.
Nine-month clinical studies involving more than 800 patients have shown Atridox and
scaling and root planing to be superior to placebo and oral hygiene for the
efficacy parameters of attachment level, probing depth, and bleeding on probing.
The positive clinical effects are consistent throughout a wide range of patients
with varied histories of periodontal therapy. The implications of these findings as
they relate to clinical practice are briefly addressed.
AN - rayyan-563561001
AU - Johnson, L. R.
AU - Stoller, N. H.
IS - 4
doxycycline
doxycycline hyclate
drug derivative
animal
bioremediation
clinical trial
gel
gingiva
human
metabolism
periodontitis
recurrent disease
review
tooth calculus
LA - English
PY - 1999
SN - 1548-8578
SP - 19-25; quiz 35
ST - Rationale for the use of Atridox therapy for managing periodontal patients
TI - Rationale for the use of Atridox therapy for managing periodontal patients
VL - 20
ID - 14375
ER -
TY - JOUR
AN - rayyan-563561149
AU - Johnson, P. W.
AU - Ng, W.
AU - Tonzetich, J.
DO - 10.1111/j.1600-0765.1992.tb01820.x
IS - 5
KW - amino acid
ascorbic acid
bicarbonate
collagen
DNA
glutamine
glycine
methanethiol
penicillin G
proline
protein
pyruvic acid
streptomycin
thiol derivative
amino acid transport
animal tissue
article
cell metabolism
controlled study
DNA synthesis inhibition
fibroblast culture
gel electrophoresis
gingiva
human
human cell
mucosa
nonhuman
periodontal disease
protein content
pig
LA - English
PY - 1992
SN - 0022-3484
SP - 476-483
ST - Modulation of human gingival fibroblast cell metabolism by methyl mercaptan
TI - Modulation of human gingival fibroblast cell metabolism by methyl mercaptan
VL - 27
ID - 14523
ER -
TY - JOUR
AB - Stabilizing or reducing periodontal pocket depth can have a positive
influence on the retention of teeth in dogs. A topical 2% clindamycin hydrochloride
gel (CHgel) was evaluated for the treatment of periodontal disease in dogs. The
CHgel formulation provides for the sustained erosion of the matrix, but also flows
into the periodontal pocket as a viscous liquid, and then rapidly forms a gel that
has mucoadhesive properties and also may function as a physical barrier to the
introduction of bacteria. A professional teeth cleaning procedure including scaling
and root planing was done in dogs with one group receiving CHgel following
treatment. Periodontal health was determined before and after the procedure
including measurement of periodontal pocket depth, gingival index, gingival
bleeding sites, and number of suppurating sites. There was a statistically
significant decrease in periodontal pocket depth (19%), gingival index (16%), and
the number of bleeding sites (64%) at 90-days in dogs receiving CHgel.
Additionally, the number of suppurating sites was lower (93%) at 90-days for the
group receiving CHgel. The addition of CHgel effectively controlled the bacterial
burden (e.g, Fusobacterium nucleatum) at both day 14 and 90. Gingival cells in
culture were shown to rapidly incorporate clindamycin and attain saturation in
approximately 20-minutes. In summary, a professional teeth cleaning procedure
including root planning and the addition of CHgel improves the gingival index and
reduces periodontal pocket depth.
AN - rayyan-563560573
AU - Johnston, T. P.
AU - Mondal, P.
AU - Pal, D.
AU - MacGee, S.
AU - Stromberg, A. J.
AU - Alur, H.
IS - 4
clindamycin
toothpaste
animal
animal disease
article
chemistry
clinical trial
controlled study
dog
dog disease
female
gel
male
mouth hygiene
periodontal disease
treatment outcome
LA - English
PY - 2011
SN - 0898-7564
SP - 224-229
ST - Canine periodontal disease control using a clindamycin hydrochloride gel
T2 - J Vet Dent
TI - Canine periodontal disease control using a clindamycin hydrochloride gel
VL - 28
ID - 13947
ER -
TY - JOUR
AB - This study examined the creep behavior and oscillatory and flow properties of
tetracycline-containing, bioadhesive semisolid formulations, designed for localized
treatment of periodontal disease. Formulations were prepared containing hydroxy-
ethylcellulose (HEC, 1, 3, or 5% w/w), poly(vinylpyrrolidone) (PVP, 2 or 3% w/w),
polycarbophil (PC, 1 or 3% w/w), and tetracycline (5% w/w, as the hydrochloride),
In creep analysis, each formulation exhibited several distinct regions that were
mathematically modelled using a multi-element Voigt model with a residual spring
and dashpot. Increasing the concentrations of each polymeric component decreased
the elastic compliance (J(0)) yet increased the residual viscosity. In oscillatory
analysis, increased polymer concentrations increased the storage modulus (G'), the
loss modulus (G") and the dynamic viscosity (eta'), yet decreased the loss tangent
(tan delta). The relationships between G' or G" and frequency were observed to
plateau at higher frequencies, which is indicative of polymer chain entanglement
and network formation. With the exception of formulations containing 1% HEC, the
formulations were elastic (tan delta < 1), with large G' and small J(0) values. All
formulations exhibited pseudoplastic flow with thixotropy. Increasing
concentrations of each polymeric component increased the zero-shear viscosity
(determined using the Cross model) and was further evidence of polymer chain
entanglement. Formulations containing 1% w/w HEC possessed excellent flow
properties, however, their thixotropic behavior and essentially elastoviscous
nature (large J(0) and tan delta) would be disadvantageous for use in the treatment
of periodontal disease because of rapid removal from the pocket and relatively
uncontrolled drug release. Despite their advantageous viscoelastic properties, the
flow properties of formulations containing 5% w/w HEC were inappropriate, rendering
administration through a periodontal syringe potentially difficult. Based on their
rheological behavior, formulations containing HEC (3% w/w), PVP (2 or 3% w/w), and
PC (1 or 3% w/w) would be suitable for clinical application. However, consideration
of other physicochemical properties (e.g., bioadhesion, drug release kinetics) must
be performed prior to selection of the most suitable formulation for clinical
examination. This study has highlighted the successful complimentary application of
creep analysis and oscillatory and flow rheometry for the characterization and
development of bioadhesive semisolid formulations for the treatment of periodontal
disease. (C) 2001 Wiley-Liss, Inc. and the American Pharmaceutical Association.
AN - rayyan-563562475
AU - Jones, D. S.
AU - Brown, A. F.
AU - Woolfson, A. D.
DO - 10.1002/jps.1149
IS - 12
PY - 2001
SN - 0022-3549
SP - 1978-1990
ST - Rheological characterization of bioadhesive, antimicrobial, semisolids
designed for the treatment of periodontal diseases: Transient and dynamic
viscoelastic and continuous shear analysis
T2 - JOURNAL OF PHARMACEUTICAL SCIENCES
TI - Rheological characterization of bioadhesive, antimicrobial, semisolids
designed for the treatment of periodontal diseases: Transient and dynamic
viscoelastic and continuous shear analysis
VL - 90
Y2 - 12
ID - 15849
ER -
TY - JOUR
AN - rayyan-563562124
AU - Jones, D. S.
AU - Brown, A. F.
AU - Coulter, W. A.
AU - McClelland, C.
AU - Irwin, C. R.
DO - 10.1016/S0168-3659(00)00231-5
IS - 2
PY - 2000
SP - 357-368
ST - Design, characterisation and preliminary clinical evaluation of a novel
mucoadhesive topical formulation containing tetracycline for the treatment of
periodontal disease
T2 - Journal of Controlled Release
TI - Design, characterisation and preliminary clinical evaluation of a novel
mucoadhesive topical formulation containing tetracycline for the treatment of
periodontal disease
0034601173&doi=10.1016%2fS0168-3659%2800%2900231-
5&partnerID=40&md5=86a403740d7bdb0655e8b06d8dac8a1e
VL - 67
ID - 15498
ER -
TY - JOUR
AB - Data sourcesMedline, Embase, Cochrane CENTRAL and OpenGREY databases without
language restriction until March 2016 plus manual searching of four specific
journals and consideration of reference lists.Study selectionStudies evaluating
different methods of periodontal treatment in Down syndrome patients measuring at
least two periodontal parameters at different periods of assessment. Titles,
abstracts and full texts were considered by two independent reviewers and a third
where discussion did not reach consensus. Randomised controlled trials were
evaluated using the Cochrane risk of bias tool. The observational studies were
evaluated using an adapted version of the Newcastle-Ottawa Scale.Data extraction
and synthesisData extraction was carried out independently by two reviewers and
organised into evidence tables. No meta-analysis was undertaken, however a
narrative synthesis was presented.ResultsNine studies met the inclusion criteria;
four longitudinal studies, one prospective case series and four clinical trials
which included two cross-over studies and a controlled trial. The studies showed
marked heterogeneity in terms of methodology, intervention and outcome measures.
All studies, however, included assessment of different plaque and gingival
indices.Three studies investigated outcomes after scaling and root planing, one of
which compared surgical and non-surgical approaches. Periodontal pockets of 1-3 mm
were statistically significantly improved with non-surgical treatment in comparison
with pockets greater than 4 mm which showed greater reduction with surgical
treatment. Six studies investigated different forms and uses of chlorhexidine,
three of which investigated its use as an adjuvant to mechanical debridement and
one which also included plaque disclosing as an intervention. Chlorhexidine was
shown to be most effective when used daily as a 1% gel for toothbrushing. The use
of a plaque disclosing tablet and fluoridated tooth paste, however, showed further
improved outcomes with regards to plaque control.ConclusionsEight of the nine
studies included showed improvement in the primary outcomes of improved plaque and
gingival bleeding indices. Professional intervention and periodontal maintenance
significantly reduced plaque and gingival indices, irrespective of the treatment
performed. Increased frequency of interventions was associated with better
outcomes, especially in younger age groups.
AN - rayyan-563560325
AU - Jones, D.
AU - Morrison, J.
DO - 10.1038/sj.ebd.6401198
IS - 4
KW - chlorhexidine
mouthwash
complication
dental scaling
Down syndrome
evidence based dentistry
human
periodontal pocket
root planing
LA - English
PY - 2016
SN - 1476-5446
SP - 101-102
ST - Preventative therapies and periodontal interventions for Down syndrome
patients
T2 - Evid Based Dent
TI - Preventative therapies and periodontal interventions for Down syndrome
patients
VL - 17
ID - 13699
ER -
TY - JOUR
AB - Periodontitis is an inflammatory disease of gums involving the degeneration
of periodontal ligaments, creation of periodontal pocket and resorption of alveolar
bone, resulting in the disruption of the support structure of teeth. According to
WHO, 10-15% of the global population suffers from severe periodontitis. The disease
results from the growth of a diverse microflora (especially anaerobes) in the
pockets and release of toxins, enzymes and stimulation of bodys immune response.
Various local or systemic approaches were used for an effective treatment of
periodontitis. Currently, controlled local drug delivery approach is more favorable
as compared to systemic approach because it mainly focuses on improving the
therapeutic outcomes by achieving factors like site-specific delivery, low dose
requirement, bypass of first-pass metabolism, reduction in gastrointestinal side
effects and decrease in dosing frequency. Overall it provides a safe and effective
mode of treatment, which enhances patient compliance. Complete eradication of the
organisms from the sites was not achieved by using various surgical and mechanical
treatments. So a number of polymer-based delivery systems like fibers, films,
chips, strips, microparticles, nanoparticles and nanofibers made from a variety of
natural and synthetic materials have been successfully tested to deliver a variety
of drugs. These systems are biocompatible and biodegradable, completely fill the
pockets, and have strong retention on the target site due to excellent mucoadhesion
properties. The review summarizes various available and recently developing
targeted delivery devices for the treatment of periodontitis.
AN - rayyan-563560352
AU - Joshi, D.
AU - Garg, T.
AU - Goyal, A. K.
AU - Rath, G.
DO - 10.3109/10717544.2014.935531
IS - 2
liposome
nanofiber
nanoparticle
article
fiber
film
gel
human
immune response
low drug dose
mucoadhesion
patient compliance
periodontitis
priority journal
strip
LA - English
PY - 2016
SN - ["1521-0464", "1071-7544"]
SP - 363-377
ST - Advanced drug delivery approaches against periodontitis
T2 - Drug Deliv.
TI - Advanced drug delivery approaches against periodontitis
VL - 23
ID - 13726
ER -
TY - JOUR
AB - Objective: The objective of the present work was to formulate
thermoreversible sol gel of cefuroxime axetil using Pluronic F127 and Pluronic
F108. Cefuroxime axetil is a broad spectrum, second generation antibiotic used to
treat various infectious diseases. Thermoreversible sol gels are shear thinning
systems which show temperature dependent gelation. Once injected, the gel covers
every nook and corner of the periodontal pocket thus filling it completely and is
retained in the pocket. Methods: Gels were prepared by cold technique varying the
polymer concentration. Results: The FTIR results revealed the compatibility between
the drug and polymers. Drug content prior and after gelation was found to be in the
range 98.8-99.8% and 98.2-99.6% respectively. The pH was in range of 6.9-7.1. The
viscosity of the formulations at 25°±1°C and 37°±1°C was in the range of 530-705
cps and 1000-2100 cps respectively. The results obtained were in agreement with the
phase transition. All the formulations were syringeable through 20 gauge needle.
The in vitro drug release revealed a sustained profile over a period of 7 days and
was found to be highest for formulation F3 i.e. 97.83%. The in vitro antimicrobial
study showed promising activity of F3 against clinical isolates of P.gingivalis,
E.faecalis and S.mutans. Short term stability study indicated that 4°±1°C is
appropriate storage condition for the formulations. Conclusion: The results
indicated that the formulated sol gel can definitely be used for once a week
treatment for periodontitis.
AN - rayyan-563560445
AU - Joshi, M.
AU - Bolmal, U.
AU - Dandagi, P.
IS - 7
KW - benzalkonium chloride
cefuroxime axetil
poloxamer
article
drug content
drug formulation
drug release
drug screening
drug stability
gel strength
gelation
gelation temperature
gelation time
nonhuman
periodontitis
pH
physical parameters
sol-gel
syringeability
viscosity
LA - English
PY - 2014
SN - 0975-1491
SP - 498-503
ST - Formulation and evaluation of cefuroxime axetil sol gel for periodontits
TI - Formulation and evaluation of cefuroxime axetil sol gel for periodontits
VL - 6
ID - 13819
ER -
TY - JOUR
AN - rayyan-563561194
AU - Joyston-Bechal, S.
AU - Smales, F. C.
AU - Duckworth, R.
KW - chlorhexidine
placebo
abstract report
clinical study
drug administration
drug efficacy
drug therapy
drug withdrawal
human cell
mouth
mouth hygiene
periodontal disease
plaque
therapy
tooth
LA - English
PY - 1979
SN - 0022-0345
SP - 1254
ST - The use of a chlorhexidine gel in a plaque control programme and its residual
effect after withdrawal
T2 - J. DENT. RES.
TI - The use of a chlorhexidine gel in a plaque control programme and its residual
effect after withdrawal
VL - 58
ID - 14568
ER -
TY - JOUR
AN - rayyan-563561196
AU - Smales, F. C.
AU - Duckworth, R.
IS - 4
chlorhexidine
placebo
adolescent
adult
aged
article
female
gel
human
middle aged
mouth hygiene
periodontal disease
pregnancy
tooth plaque
LA - English
PY - 1979
SN - 0007-0610
SP - 105-111
ST - The use of a chlorhexidine-containing gel in a plaque control programme
T2 - Br Dent J
TI - The use of a chlorhexidine-containing gel in a plaque control programme
VL - 146
ID - 14570
ER -
TY - JOUR
AN - rayyan-563561190
AU - Smales, F. C.
AU - Duckworth, R.
IS - 4
KW - chlorhexidine
metronidazole
abstract report
mouth
periodontal disease
therapy
tooth
corsodyl
LA - English
PY - 1982
SN - 0022-0345
SP - 550
ST - The effects of metronidazole and a topically-applied chlorhexidine gel on
chronic periodontal disease
T2 - J. DENT. RES.
TI - The effects of metronidazole and a topically-applied chlorhexidine gel on
chronic periodontal disease
VL - 61
ID - 14564
ER -
TY - JOUR
AB - A double blind between subject comparison of the effect of metronidazole and
placebo tablets was completed over 22 weeks in 45 subjects with chronic periodontal
disease ranging in severity from moderate (PI=2.0-3.9) to high (PI=4.0-6.0). All
subjects used a topically applied chlorhexidine gel for the first 10 weeks.
Throughout the trial plaque, bleeding and calculus were assessed on the buccal,
lingual, mesial and distal surfaces of teeth 16, 21, 24, 36, 41 and 44 and their
supporting tissues. The pocket depths on the same 4 aspects of all teeth present
were measured. The regime employed consisted of oral hygiene instruction (OHI) at
the initial visit followed by scaling and further OHI at visits 1 and 2 weeks
later. After the third visit 16 x 200 mg metronidazole or placebo tablets were
issued with instructions to take 1 that evening and 3 per day at 5-h intervals for
the next 5 days. 4 weeks later, scaling and OHI were carried out and the course of
test or placebo tablets was repeated. The subjects returned for further scaling and
OHI 4 weeks later and the chlorhexidine gel was withdrawn. Final assessments were
made 12 weeks later. The results showed that metronidazole had no effect on plaque
levels and gingival bleeding beyond the effect of OHI, scaling and chlorhexidine
gel. On the other hand, significantly greater reductions in pocket depths were
achieved with the use of metronidazole. A surprising and interesting finding was
that these reductions were apparent only in the subjects with severe periodontal
disease (PI=4.0-6.0).
AN - rayyan-563561183
AU - Smales, F. C.
AU - Duckworth, R.
DO - 10.1111/j.1600-051X.1984.tb01308.x
IS - 1
KW - chlorhexidine
metronidazole
placebo
clinical article
clinical trial
controlled study
drug therapy
human
mouth
periodontitis
therapy
tooth
corsodyl
LA - English
PY - 1984
SN - 0303-6979
SP - 53-62
ST - Effect of metronidazole on chronic periodontal disease in subjects using a
topically applied chlorhexidine gel
TI - Effect of metronidazole on chronic periodontal disease in subjects using a
topically applied chlorhexidine gel
VL - 11
ID - 14557
ER -
TY - JOUR
AB - Aims: Periodontitis is a chronic inflammatory disease that results in
gingival inflammation and periodontal tissue destruction and is accompanied by
alveolar bone resorption and eventual tooth loss. We examined the effect of 15-
deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) on periodontitis by inhibiting the
production of interleukin-6 (IL-6). Main methods: Osteoblast-like cells MC3T3E-1
were pretreated with 15d-PGJ2 before being incubated with lipopolysaccharide (LPS),
the effect of 15d-PGJ2 on IL-6 production, expression and its regulatory mechanisms
were studied by reverse transcription-polymerase chain reaction (RT-PCR), Western
blot, electrophoretic mobility shift assay (EMSA), and confocal laser scanning
microscopy study. Key findings: 15d-PGJ2 inhibits LPS-stimulated IL-6 production in
a concentration-dependent manner in osteoblast-like cells MC3T3E-1, without
appreciable cytotoxicity. To further examine the mechanism responsible for the
inhibition of IL-6 production by 15d-PGJ2, we examined the effect of 15d-PGJ2 on
nuclear factor-κB (NF-κB) activation and the phosphorylation of protein kinase B
(Akt). 15d-PGJ2 treatment clearly reduced the DNA binding activity of NF-κB in LPS-
stimulated osteoblast-like cells MC3T3E-1, an effect that was mediated by
inhibiting the degradation of inhibitor κB (IκB) and nuclear translocation of NF-κB
p65 subunit. In addition, 15d-PGJ2 attenuated the LPS-mediated Akt pathway. These
effects of 15d-PGJ2 were not abrogated by the PPARγ antagonist, GW9662, indicating
that they are PPARγ-independent actions. Significance: These results suggest that
15d-PGJ2 possess a potent suppressive effect on inflammatory responses of
osteoblast-like cells MC3T3E-1 via the Akt and NF-κB pathways independent of PPARγ
and suggest that this compound may offer some insight into the development of a new
therapeutic approach to the prevention and treatment of periodontal diseases. ©
2009 Elsevier Inc. All rights reserved.
AN - rayyan-563560673
AU - Jung, W. K.
AU - Park, I. S.
AU - Park, S. J.
AU - Yea, S. S.
AU - Choi, Y. H.
AU - Oh, S.
AU - Park, S. G.
AU - Choi, I. W.
DO - 10.1016/j.lfs.2009.04.010
IS - 1
KW - 15 deoxy delta12,14 prostaglandin J2
2 chloro 5 nitrobenzanilide
DNA
I kappa B
interleukin 6
lipopolysaccharide
protein kinase B
transcription factor RelA
animal cell
article
binding affinity
cytokine production
cytotoxicity
DNA binding
drug effect
enzyme activation
enzyme inhibition
mouse
nonhuman
osteoblast
periodontitis
protein expression
Western blotting
LA - English
PY - 2009
SN - 0024-3205
SP - 46-53
ST - The 15-Deoxy-Δ12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-κB
activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1
T2 - Life Sci.
TI - The 15-Deoxy-Δ12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-κB
activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1
VL - 85
ID - 14047
ER -
TY - JOUR
AB - MATERIALS AND METHODS: Sodium hypochlorite formulation (NaOCl gel), its
components sodium hypochlorite (NaOCl), and the activating vehicle were compared
with 0.1 % chlorhexidine digluconate (CHX) solution. The antimicrobial activity was
proven by determination of minimal inhibitory concentrations (MIC), minimal
bactericidal concentrations, and killing assays. Furthermore, the influence on
formation as well as on a 4-day-old 6-species biofilm was tested. RESULTS: Except
for one strain (Parvimonas micra ATCC 33270 in case of NaOCl gel), the MICs both of
the CHX solution and NaOCl gel did not exceed 10 % of the formulations'
concentration. In general, MICs of the NaOCl gel were equal as of the CHX solution
against Gram-negatives but higher against Gram-positive bacteria. CHX but not NaOCl
gel clearly inhibited biofilm formation; however, the activity of NaOCl gel was
more remarkable on a 4-day-old biofilm. NaOCl killed bacteria in the biofilm and
interfered with the matrix. CONCLUSIONS: The NaOCl gel acts antimicrobial in
particular against Gram-negative species associated with periodontitis. Moreover,
its component NaOCl hypochlorite is able to alter biofilm matrices. CLINICAL
RELEVANCE: The NaOCl gel may represent a potential alternative for adjunctive
topical antimicrobial treatment in periodontitis. OBJECTIVES: The aim of the
present study was to assess the antimicrobial activity of a sodium hypochlorite
formulation including its components against bacteria associated with periodontal
disease.
AN - rayyan-563560331
AU - Jurczyk, K.
AU - Nietzsche, S.
AU - Ender, C.
AU - Sculean, A.
AU - Eick, S.
IS - 8
KW - chlorhexidine
gel
hypochlorite sodium
biofilm
comparative study
drug effect
in vitro study
microbiology
periodontal disease
stem cell
LA - English
PY - 2016
SN - 1436-3771
SP - 2165-2173
ST - In-vitro activity of sodium-hypochlorite gel on bacteria associated with
periodontitis
TI - In-vitro activity of sodium-hypochlorite gel on bacteria associated with
periodontitis
VL - 20
ID - 13705
ER -
TY - COMP
AB - OBJECTIVES: The aim of the present study was to assess the antimicrobial
activity of a sodium hypochlorite formulation including its components against
bacteria associated with periodontal disease. MATERIALS AND METHODS: Sodium
hypochlorite formulation (NaOCl gel), its components sodium hypochlorite (NaOCl),
and the activating vehicle were compared with 0.1 % chlorhexidine digluconate (CHX)
solution. The antimicrobial activity was proven by determination of minimal
inhibitory concentrations (MIC), minimal bactericidal concentrations, and killing
assays. Furthermore, the influence on formation as well as on a 4-day-old 6-species
biofilm was tested. RESULTS: Except for one strain (Parvimonas micra ATCC 33270 in
case of NaOCl gel), the MICs both of the CHX solution and NaOCl gel did not exceed
10 % of the formulations' concentration. In general, MICs of the NaOCl gel were
equal as of the CHX solution against Gram-negatives but higher against Gram-
positive bacteria. CHX but not NaOCl gel clearly inhibited biofilm formation;
however, the activity of NaOCl gel was more remarkable on a 4-day-old biofilm.
NaOCl killed bacteria in the biofilm and interfered with the matrix. CONCLUSIONS:
The NaOCl gel acts antimicrobial in particular against Gram-negative species
associated with periodontitis. Moreover, its component NaOCl hypochlorite is able
to alter biofilm matrices. CLINICAL RELEVANCE: The NaOCl gel may represent a
potential alternative for adjunctive topical antimicrobial treatment in
periodontitis.
AN - rayyan-563561112
AU - Jurczyk, K.
AU - Nietzsche, S.
AU - Ender, C.
AU - Sculean, A.
AU - Eick, S.
CY - Germany
DO - 10.1007/s00784-016-1711-9
ET - 8
J2 - Clin Oral Investig
KW - Anti-Infective Agents, Local/pharmacology
Biofilms/drug effects
Chlorhexidine/analogs & derivatives/pharmacology
Gels
In Vitro Techniques
Periodontal Diseases/*drug therapy/*microbiology
Sodium Hypochlorite/*pharmacology
Stem Cells
LA - eng
N1 - Department of Periodontology, Laboratory of Oral Microbiology, School of
Dental Medicine, University of Bern, Freiburgstrasse 7, CH-3010, Bern,
Switzerland.; Department of Conservative Dentistry and Periodontology, Poznan
University of Medical Sciences, Poznan, Poland.; Center of Electron Microscopy,
University Hospital Jena, Jena, Germany.; Center of Electron Microscopy, University
Hospital Jena, Jena, Germany.; Department of Periodontology, Laboratory of Oral
Microbiology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, CH-
3010, Bern, Switzerland.; Department of Periodontology, Laboratory of Oral
Microbiology, School of Dental Medicine, University of Bern, Freiburgstrasse 7, CH-
3010, Bern, Switzerland. sigrun.eick@zmk.unibe.ch.
PY - 2016
SP - 2165-2173
ST - In-vitro activity of sodium-hypochlorite gel on bacteria associated with
periodontitis
T2 - Clinical oral investigations
TI - In-vitro activity of sodium-hypochlorite gel on bacteria associated with
periodontitis
VL - 20
Y2 - 11
ID - 14486
ER -
TY - JOUR
AB - Background and Objective: Periodontitis is a chronic inflammatory disease.
The innate immune mechanism plays a significant role in the aetiopathogenesis of
periodontal destruction. The innate immune signalling molecular factors are
regulated by small noncoding RNAs called microRNAs (miRNAs). miR-499 targets many
inflammatory cytokine gene mRNAs and has been associated with many inflammatory
diseases like rheumatoid arthritis and cardiovascular diseases. Single nucleotide
polymorphisms (SNPs) are found to be genetic factors of periodontitis. Not much
information is available on miRNA SNP and periodontitis. Thus, the aim of the
present study was to find the association of miR-499 rs3746444 gene polymorphism
with chronic periodontitis, aggressive periodontitis and healthy controls.
Materials and methods: This is a case–control study and includes 80 aggressive
periodontitis cases, 81 chronic periodontitis cases and 167 healthy controls. DNA
extraction was extracted from the peripheral blood lymphocytes, and the PCR
amplification of rs3746444 region of miR-499 gene was done. The amplified products
were restriction-digested using the enzyme Bcl1. The restriction-digested products
were analysed by electrophoresis on a 3% agarose gel. Results: Our study results
showed no significant association of genotypes of miR-499 rs3746444 with chronic
periodontitis (OR 0.91, CI = 0.39–2.01 and p =.813) and aggressive periodontitis in
this study population (OR 0.38, CI = 0.12–1.02 and p =.054). The C allele of
rs3746444 could be a protective allele in the susceptibility to aggressive
periodontitis (OR 0.64; 95% CI = 0.42–0.99; p =.043). There was no significant
association of chronic periodontitis as far as miR-499 rs3746444 genotypes were
concerned. Conclusion: Our study concludes that there is no significant association
of miR-499 rs3746444 polymorphism with periodontitis in this study population.
AN - rayyan-563560069
AU - Kaarthikeyan, G.
AU - Anand, B.
DO - 10.1111/iji.12508
IS - 6
KW - agarose
antibiotic agent
DNA
membrane protein
microRNA
microRNA 499
protein bcl 1
unclassified drug
adult
antibiotic therapy
article
case control study
confidence interval
controlled study
DNA extraction
electrophoresis
female
gene amplification
gene frequency
genetic association
genotype
human
human cell
male
middle aged
odds ratio
peripheral lymphocyte
priority journal
LA - English
PY - 2020
SN - ["1744-313X", "1744-3121"]
SP - 485-493
ST - Association analysis of miR-499 rs3746444 gene polymorphism with
periodontitis
T2 - Int. J. Immunogenet.
TI - Association analysis of miR-499 rs3746444 gene polymorphism with
periodontitis
VL - 47
ID - 13443
ER -
TY - JOUR
AB - OBJECTIVE: Systemic antibiotics and locally applied antimicrobial agents have
been suggested to enhance clinical parameters. Patients exhibiting aggressive
periodontitis in particular benefit from adjunctive antibiotic therapy. The purpose
of this investigation was to evaluate the effect of local antibiotic therapy with
metronidazole adjunctively to scaling and root planning (SRP) in the treatment of
aggressive periodontitis. MATERIALS AND METHODS: Twenty patients diagnosed with
aggressive periodontitis were placed in a spilt mouth design. Microbial specimens
were taken from the deepest pocket of the teeth. The sites that had positive
results of Porphyromonas gingivalis (P.g) were located randomly to receive SRP
treatment in the control group and SRP plus metronidazole gel in the test group.
Pocket probing depth (PPD), clinical attachment level (CAL) and bleeding on probing
(BOP) parameters and numbers of P.g. colony were taken at baseline, 6 weeks and 12
weeks later. All data were collected and analyzed and tested by Wilcoxon and paired
t test. RESULTS: The case group patients had significantly better results in BOP,
PPD and the number of P.g colony count reduction in comparison with the control
group (p<0.05). According to the measurements of CAL, the statistical difference
was non significant (p>0.05). CONCLUSION: In non-surgical periodontal treatment of
aggressive periodontits adjunctive metronidazole gel therapy has a better effect on
the reduction of porphyromonas gingivalis content of pockets.
AN - rayyan-563560807
AU - Kadkhoda, Z.
AU - Tari, S. R.
AU - Owlia, P.
AU - Sabounchei, S. S.
IS - 1
J2 - J Dent (Tehran)
LA - eng
N1 - Associated Professor ,Department of Periodontology, School of Dentistry,
University of Medical Science, Tehran ,Iran.
PY - 2012
SP - 50-8
ST - Comparison of 1-periodontal indices and cultural porphyromonas gingivalis
colony count in aggressive periodontitis patients treated by scaling and
rootplanning with or without metronidazole gel
T2 - Journal of dentistry (Tehran, Iran)
TI - Comparison of 1-periodontal indices and cultural porphyromonas gingivalis
colony count in aggressive periodontitis patients treated by scaling and
rootplanning with or without metronidazole gel
VL - 9
ID - 14181
ER -
TY - JOUR
AB - Aims: To characterize the antimicrobial activity produced by Prevotella
nigrescens ATCC 25261, and to evaluate its safety on cultured gingival fibroblasts.
Methods and Results: An antimicrobial activity was obtained from purifying the
culture supernatant of Pr. nigrescens ATCC 25261. Purification of the active
compound was achieved with ammonium sulphate precipitation followed by anion-
exchange and gel filtration chromatography. As revealed by SDS-PAGE, the active
fraction was relatively homogeneous, showing a protein with an approximate
molecular weight of 41 kDa. The antimicrobial compound, named nigrescin, exhibited
a bactericidal mode of action against Porphyromonas gingivalis, Prevotella
intermedia, Tannerella forsythensis, and Actinomyces spp. Nigrescin was stable in a
pH range between 6.5 and 9.5, at 100°C for 10 min, and resistant to lyophilization.
But its activity was lost after proteinase K treatment. Despite at very high
concentrations beyond the minimum inhibitory concentration (MIC), nigrescin was not
toxic to the gingival fibroblasts. Conclusion: Nigrescin is a novel bacteriocin
produced by Pr. nigrescens ATCC 25261. It exhibits antimicrobial activity against
species that are implicated in periodontal diseases. The absence of toxicity on the
gingival fibroblasts suggests the possibility in using of nigrescin for an
application in periodontal treatment. Significance and Impact of the Study: Novel
evidence on nigrescin would make Pr. nigrescens ATCC 25261 attractive in
biotechnological applications as an antimicrobial agent in clinical dentistry.
AN - rayyan-563560872
AU - Kaewsrichan, J.
AU - Douglas, C. W. I.
AU - Nissen-Meyer, J.
AU - Fimland, G.
AU - Teanpaisan, R.
DO - 10.1111/j.1472-765X.2004.01608.x
IS - 5
KW - ammonium sulfate
bacteriocin
nigrescin
proteinase K
unclassified drug
article
bacterium culture
fibroblast
gingiva
nonhuman
periodontal disease
strain difference
supernatant
LA - English
PY - 2004
SN - 0266-8254
SP - 451-458
ST - Characterization of a bacteriocin produced by Prevotella nigrescens ATCC
25261
T2 - Lett. Appl. Microbiol.
TI - Characterization of a bacteriocin produced by Prevotella nigrescens ATCC
25261
VL - 39
ID - 14246
ER -
TY - JOUR
AB - AIMS: To characterize the antimicrobial activity produced by Prevotella
nigrescens ATCC 25261, and to evaluate its safety on cultured gingival fibroblasts.
METHODS AND RESULTS: An antimicrobial activity was obtained from purifying the
culture supernatant of Pr. nigrescens ATCC 25261. Purification of the active
compound was achieved with ammonium sulphate precipitation followed by anion-
exchange and gel filtration chromatography. As revealed by SDS-PAGE, the active
fraction was relatively homogeneous, showing a protein with an approximate
molecular weight of 41 kDa. The antimicrobial compound, named nigrescin, exhibited
a bactericidal mode of action against Porphyromonas gingivalis, Prevotella
intermedia, Tannerella forsythensis, and Actinomyces spp. Nigrescin was stable in a
pH range between 6.5 and 9.5, at 100 degrees C for 10 min, and resistant to
lyophilization. But its activity was lost after proteinase K treatment. Despite at
very high concentrations beyond the minimum inhibitory concentration (MIC),
nigrescin was not toxic to the gingival fibroblasts. CONCLUSION: Nigrescin is a
novel bacteriocin produced by Pr. nigrescens ATCC 25261. It exhibits antimicrobial
activity against species that are implicated in periodontal diseases. The absence
of toxicity on the gingival fibroblasts suggests the possibility in using of
nigrescin for an application in periodontal treatment. SIGNIFICANCE AND IMPACT OF
THE STUDY: Novel evidence on nigrescin would make Pr. nigrescens ATCC 25261
attractive in biotechnological applications as an antimicrobial agent in clinical
dentistry.
AN - rayyan-563561364
AU - Kaewsrichan, J.
AU - Douglas, C. W.
AU - Nissen-Meyer, J.
AU - Fimland, G.
AU - Teanpaisan, R.
DO - 10.1111/j.1472-765X.2004.01608.x
IS - 5
J2 - Lett Appl Microbiol
KW - Actinomyces/drug effects
Ammonium Sulfate
Anti-Bacterial Agents/chemistry/isolation & purification/pharmacology/toxicity
Bacteriocins/chemistry/*isolation & purification/*pharmacology/toxicity
Cells, Cultured
Chromatography, Gel
Chromatography, Ion Exchange
Endopeptidase K/metabolism
Enzyme Stability
Fibroblasts/cytology/drug effects
Fractional Precipitation
Freeze Drying
Gingiva/cytology/drug effects
Humans
Hydrogen-Ion Concentration
Molecular Weight
Prevotella intermedia/drug effects
Prevotella nigrescens/*metabolism
Temperature
LA - eng
N1 - Department of Stomatology, Faculty of Dentistry, Prince of Songkla
University, Hat-Yai, Songkhla 90112, Thailand. mjasdee@ratree.psu.ac.th
PY - 2004
SN - 0266-8254 (Print)
SP - 451-8
ST - Characterization of a bacteriocin produced by Prevotella nigrescens ATCC
25261
T2 - Letters in applied microbiology
TI - Characterization of a bacteriocin produced by Prevotella nigrescens ATCC
25261
VL - 39
ID - 14738
ER -
TY - JOUR
AN - rayyan-563561499
AU - Kairey, L.
AU - Agnew, T.
AU - Bowles, E. J.
AU - Barkla, B. J.
AU - Wardle, J.
AU - Lauche, R.
DO - 10.3389/fphar.2023.1116077
PY - 2023
ST - Efficacy and safety of Melaleuca alternifolia (tea tree) oil for human health
—A systematic review of randomized controlled trials
T2 - Frontiers in Pharmacology
TI - Efficacy and safety of Melaleuca alternifolia (tea tree) oil for human health
—A systematic review of randomized controlled trials
85153373643&doi=10.3389%2ffphar.2023.1116077&partnerID=40&md5=e797a5204f7b5ad109277
97cc913a8dd
VL - 14
ID - 14873
ER -
TY - JOUR
AB - Clinical and microbiological effects of subgingival application of a 1%
chlorhexidine gel were studied. Eleven patients with chronic periodontitis
participated in the study. In each patient two pairs of single rooted teeth with at
least 20% attachment loss and probing depth > 4 mm were selected. Contralateral
sites were randomly allocated to test and control groups receiving chlorhexidine or
placebo gel respectively. The gels were applied once daily for two consecutive
days. The clinical parameters comprised plaque index, gingival index, probing
pocket depth and bleeding on probing. The composition of the subgingival microbiota
was estimated with use of dark field microscopy. Baseline measurements were taken
two weeks prior to chlorhexidine application. Microbiological and clinical
parameters were further monitored 2, 7, 14 and 28 days after the last gel
application. Chlorhexidine gel application did not significantly change the
composition of the microflora compared to placebo application. There were no major
differences in plaque and gingival indices. Effects on probing pocket depth of the
chlorhexidine gel application may have been disguised by an influence from the
diameter of the needle with which the application was performed. Needles with a
diameter of 25G resulted in increases in probing pocket depth which indicates a
possible mechanical trauma. This effect was not observed when needles with a
diameter of 23G were used.
AN - rayyan-563561083
AU - Kalaitzakis, C. J.
AU - Tynelius-Bratthall, G.
AU - Attström, R.
IS - 4
KW - chlorhexidine
placebo
adult
aged
article
bacterial count
bacterium
chronic disease
clinical trial
female
gel
gingiva bleeding
human
lavage
male
microbiology
middle aged
pathology
periodontics
periodontitis
pilot study
reproducibility
tooth plaque
LA - English
PY - 1993
SN - 0347-9994
SP - 129-137
ST - Clinical and microbiological effects of subgingival application of a
chlorhexidine gel in chronic periodontitis. A pilot study
T2 - Swed Dent J
TI - Clinical and microbiological effects of subgingival application of a
chlorhexidine gel in chronic periodontitis. A pilot study
VL - 17
ID - 14457
ER -
TY - JOUR
AB - Background In daily dental practice, plaque-induced gingivitis is one of the
most common periodontal diseases that is frequently encountered. Accumulation of
microbial biofilms on surfaces of teeth and poor or inadequate oral hygiene is the
chief predisposing factor for this condition. In such a state, antimicrobial
mouthwash as an adjunct to mechanical plaque control helps in maintaining good oral
hygiene. Among the many conditions, fixed orthodontic treatment is one of the
conditions where plaque control becomes challenging to the patient as well as the
dentist. In such a situation, antimicrobial mouthwash as an adjunct to mechanical
plaque control is highly recommended. Dentistry has recently evidenced a shift of
approach for treating many inflammatory oral diseases by using herbal treatment
modalities. Aloe vera is one such product exhibiting multiple benefits and has
gained considerable importance in clinical research recently. The present study
aimed to evaluate efficacy of aloe vera mouth rinse on the dental plaque and
gingivitis in patients who were undergoing fixed orthodontic treatment in
comparison with 0.2% chlorhexidine mouthwash. Material and Method This randomized
controlled trial was conducted on 30 subjects with fixed orthodontic treatment. The
subjects were grouped in the test group (15 subjects with 10 ml aloe vera mouthwash
(99.6% [w/v])) and the control group (15 subjects with 0.2% 10 ml chlorhexidine
mouthwash). Plaque index, gingival index and bleeding on probing were recorded for
each participant at baseline, 21 days from baseline and 35 days from baseline. The
findings were then statistically analysed using student paired and unpaired t-test.
Results Gingival index showed a statistically significant difference from baseline
to 21 days and 35 days visit in both the groups. Plaque index and bleeding on
probing were statistically significant among both groups when compared baseline to
21 days and 35 days visit, but the difference was not significant between visit 2
and visit 3. Conclusions Although chlorhexidine is still the gold standard
mouthwash, aloe vera exhibits promising results in reducing plaque and gingivitis
scores, without any reported adverse effects. Larger multi-centric trials are
needed to prove its effectiveness on dental plaque-induced gingivitis.
AN - rayyan-563562618
AU - Kamath, D. G.
AU - Nadimpalli, H.
AU - Nayak, S. U.
AU - Rajendran, V.
AU - Natarajan, S.
DO - 10.1111/idh.12615
IS - 1
PY - 2023
SN - ["1601-5029", "1601-5037"]
SP - 211-218
ST - Comparison of antiplaque and anti-gingivitis effects of aloe vera mouthwash
with chlorhexidine in fixed orthodontic patients-A randomized controlled trial
T2 - INTERNATIONAL JOURNAL OF DENTAL HYGIENE
TI - Comparison of antiplaque and anti-gingivitis effects of aloe vera mouthwash
with chlorhexidine in fixed orthodontic patients-A randomized controlled trial
VL - 21
Y2 - 2
ID - 15992
ER -
TY - JOUR
AN - rayyan-563562127
AU - Kamel, E.
AU - Legrand, R.
IS - 12
PY - 1994
SP - 649-655
ST - Current aspects of topical application of antimicrobial agents in periodontal
diseases
T2 - Revue Medicale de Liege
TI - Current aspects of topical application of antimicrobial agents in periodontal
diseases
0028577714&partnerID=40&md5=e2f1dbca91773029fce5da4fde17202c
VL - 49
ID - 15501
ER -
TY - JOUR
AB - BACKGROUND: Porphyromonas gingivalis is a major pathogen and has a high
detection rate in periodontal disease. Fimbriae and hemagglutinin are expressed by
P. gingivalis, and these play an important role in the adherence of the bacteria to
periodontal tissue and biofilm formation. The aim of this study was to investigate
the effects of sub-minimal inhibitory concentrations (sub-MICs) of azithromycin on
the adherence of P. gingivalis, focusing on the inhibition of fimbriae expression
and hemagglutinin activity. METHODS: P. gingivalis ATCC 33277 were incubated
anaerobically with sub-MICs of azithromycin at 37°C by gentle shaking for 18 hours.
The bacterial cells were harvested, washed twice with phosphate-buffered saline
(PBS), and the proteins analyzed by 12% sodium dodecyl sulfate-polyacrylamide gel
electrophoresis (SDS-PAGE) and western blotting. Adherence assay and hemagglutinin
activity tests were done with the same culture. RESULTS: The results of SDS-PAGE
indicated that the sub-MICs of azithromycin inhibited 41-kDa fimbrial protein
expression and hemagglutinin activities. The disappearance of 41-kDa fimbrial
protein expression and long fimbriae in 0.4 µg/mL, 0.2 µg/mL, and 0.1 µg/mL of
azithromycin was confirmed by western blotting and transmission electron
microscopy. The adherence of P. gingivalis to human gingival epithelial cells was
reduced by sub-MICs of azithromycin compared with the adherence levels without
antibiotic. CONCLUSIONS: These results suggest that sub-MICs of azithromycin may
reduce the adherence of P. gingivalis to host cells, by inhibiting production of
fimbriae and hemagglutinin activities. Therefore, azithromycin can be used as a
biofilm treatment of periodontal disease caused by P. gingivalis.
AN - rayyan-563561116
AU - Kan, P.
AU - Sasaki, H.
AU - Inaba, K.
AU - Watanabe, K.
AU - Hamada, N.
AU - Minabe, M.
DO - 10.1002/JPER.18-0559
IS - 8
J2 - J Periodontol
KW - *Azithromycin
Bacterial Adhesion
Bacterial Proteins
Fimbriae Proteins
Fimbriae, Bacterial
Humans
*Porphyromonas gingivalis
LA - eng
N1 - Division of Periodontology, Department of Oral Interdisciplinary Medicine,
Kanagawa Dental University, Yokosuka, Japan.; Division of Microbiology, Department
of Oral Science, Kanagawa Dental University, Yokosuka, Japan.; Division of
Microbiology, Department of Oral Science, Kanagawa Dental University, Yokosuka,
Japan.; Division of Microbiology, Department of Oral Science, Kanagawa Dental
University, Yokosuka, Japan.; Division of Microbiology, Department of Oral Science,
Kanagawa Dental University, Yokosuka, Japan.; Division of Periodontology,
Department of Oral Interdisciplinary Medicine, Kanagawa Dental University,
Yokosuka, Japan.
PY - 2019
SP - 903-910
ST - Inhibitory effects of azithromycin on the adherence ability of Porphyromonas
gingivalis
TI - Inhibitory effects of azithromycin on the adherence ability of Porphyromonas
gingivalis
VL - 90
Y2 - 8
ID - 14490
ER -
TY - JOUR
AB - Saliva substitutes and/or lubricants are commonly employed to lessen dry
mouth symptoms by stimulating and/or substituting for the secretion of saliva. In
this study, a novel artificial saliva containing inorganic salts, including sodium
chloride and potassium chloride, and bactericidal agents, including potassium
thiocyanate and lactoperoxidase, was formulated in the form of a solution (DM-sol)
or gel (DM-gel). Those in vivo therapeutic efficacies were assessed in terms of
saliva secretion and anti-inflammatory activity in rats and mice, respectively.
Salivary secretion was promoted by mucosal application of DM-formulations in normal
rats. In particular, DM-gel resulted in 2.5- and 1.9-fold greater salivary flow
rates compared to normal saline and DM-sol, respectively. In an in vivo efficacy
evaluation in diabetic mice with salivary hypofunction, repeated application of DM-
formulations alleviated histopathological changes in the buccal mucosa in terms of
atrophy and thinning of the epithelium, compared to vehicle, after 4 weeks.
Moreover, the DM-sol and DM-gel were comparably effective for relieving periodontal
gingivitis, reducing infiltration of inflammatory cells, and normalizing the
neutrophil level in the gingival gingiva, after 4 weeks. Therefore, the novel
artificial saliva is expected to facilitate salivary secretion and restore
physiological conditions in the mouth of patients with salivary hypofunction.
AN - rayyan-563560315
AU - Kang, M.
AU - Park, H.
AU - Jun, J. H.
AU - Son, M.
AU - Kang, M. J.
DO - 10.2147/DDDT.S121254
KW - saliva substitute
animal experiment
animal model
animal tissue
article
atrophy
Bagg albino mouse
buccal mucosa
Candida albicans
cell infiltration
controlled study
flow rate
gel
gingivitis
histopathology
in vitro study
in vivo study
inflammatory cell
mouse
mouth inflammation
neutrophil
nonhuman
rat
salivary hypofunction
salivation
Sprague Dawley rat
LA - English
PY - 2017
SN - 1177-8881
SP - 185-191
ST - Facilitated saliva secretion and reduced oral inflammation by a novel
artificial saliva system in the treatment of salivary hypofunction
T2 - Drug Des. Dev. Ther.
TI - Facilitated saliva secretion and reduced oral inflammation by a novel
artificial saliva system in the treatment of salivary hypofunction
VL - 11
ID - 13689
ER -
TY - JOUR
AB - The purpose of the present study is to synthesize a 2-methacryloyloxyethyl
phosphorylcholine (MPC) polymer capable of being immobilized on the tooth surface
to prevent oral bacterial adhesion. The strategy is to develop an MPC-based polymer
with Ca2+-binding moieties, i.e., phosphomonoester groups, for stronger binding
with hydroxyapatite (HA) of the tooth surface. To this end, a 2-
methacryloyloxyethyl phosphate (MOEP) monomer was synthesized and copolymerized
with MPC by free radical polymerization. The coating efficiency of the synthesized
polymer, MPC-ran-MOEP (abbreviated as PMP) with varied composition, onto a HA
surface was estimated by means of contact angle measurement and X-ray photoelectron
spectroscopy. The anti-biofouling nature of PMP-coated HA surfaces was estimated by
analyzing protein adsorption, cell adhesion, and Streptococcus mutans adhesion. As
a result, HA surface coated with a copolymer containing around 50% MPC (PMP50)
showed the best performance in preventing protein adsorption and the downstream
cell and bacterial adhesion. Statement of Significance Preparation of anti-
biofouling surface on the tooth enamel is the key technique to prevent dental and
periodontal diseases, which are closely related with the biofilm formation that
induced by the adsorption of salivary proteins and the adhesion of oral bacteria on
the tooth surface. In this research, a PMP copolymer with an optimized ratio of
zwitterionic and Ca2+-binding moieties could form a highly effective and robust
anti-biofouling surface on HA surfaces by a simple coating method. The PMP-coated
surface with high stability can provide a new strategy for an anti-adsorptive and
anti-bacterial platform in dentistry and related fields.
AN - rayyan-563560338
AU - Kang, S.
AU - Lee, M.
AU - Kang, M.
AU - Noh, M.
AU - Jeon, J.
AU - Lee, Y.
AU - Seo, J. H.
DO - 10.1016/j.actbio.2016.03.006
KW - 2 methacryloyloxyethylphosphorylcholine
hydroxyapatite
polymer
unclassified drug
zwitterionic 2 methacryloyloxyethylphosphorylcholine polymer
article
bacterium adherence
biofouling
calcium binding
cell adhesion
cell viability
contact angle
eukaryotic cell
freeze drying
image analysis
microbial adhesion
molecular weight
mouth flora
nonhuman
physical stress
polymerization
priority journal
surface property
synthesis
X ray photoemission spectroscopy
LA - English
PY - 2016
SN - ["1878-7568", "1742-7061"]
SP - 70-77
ST - Development of anti-biofouling interface on hydroxyapatite surface by coating
zwitterionic MPC polymer containing calcium-binding moieties to prevent oral
bacterial adhesion
T2 - Acta Biomater.
TI - Development of anti-biofouling interface on hydroxyapatite surface by coating
zwitterionic MPC polymer containing calcium-binding moieties to prevent oral
bacterial adhesion
VL - 40
ID - 13712
ER -
TY - JOUR
AB - Treatment of severe periodontitis with non-surgical therapy remains
challenging in dentistry. The present study aimed to evaluate the clinical efficacy
of hydrogen peroxide (H2O2) photolysis-based antimicrobial chemotherapy
adjunctively performed with root debridement (RD) for moderate to severe
periodontitis. A randomized controlled trial was conducted that included 53
patients with 142 test teeth. The test teeth were randomly assigned to one of three
treatment groups: Group 1, RD + H2O2 photolysis; Group 2, RD followed by
administration of a local drug delivery system (minocycline chloride gel); or Group
3, RD alone. Clinical and microbiological examination were performed for up to 12
weeks following treatment. Probing pocket depth (PPD) and bleeding on probing (BoP)
were improved after each treatment session. At 12 weeks, Group 1 had achieved
significantly lower PPDs than the other groups, though there were no significant
differences in BoP between Group 1 and the other groups. Counts of Porphyromonas
gingivalis, a known periodontal pathogen, in Group 1 were significantly lower than
those in Group 3, and were comparable to those in Group 2. Therefore, it is
suggested that H2O2 photolysis treatment can be used as a novel adjunctive
antimicrobial chemotherapy for non-surgical periodontal treatment.
AN - rayyan-563560290
AU - Kanno, T.
AU - Nakamura, K.
AU - Ishiyama, K.
AU - Yamada, Y.
AU - Shirato, M.
AU - Niwano, Y.
AU - Kayaba, C.
AU - Ikeda, K.
AU - Takagi, A.
AU - Yamaguchi, T.
AU - Sasaki, K.
DO - 10.1038/s41598-017-12514-0
IS - 1
adult
aged
bacterial load
controlled study
debridement
drug therapy
female
gingivitis
human
Japan
male
microbiology
middle aged
periodontitis
photolysis
procedures
treatment outcome
LA - English
PY - 2017
SN - 2045-2322
SP - 12247
ST - Adjunctive antimicrobial chemotherapy based on hydrogen peroxide photolysis
for non-surgical treatment of moderate to severe periodontitis: a randomized
controlled trial
T2 - Sci Rep
TI - Adjunctive antimicrobial chemotherapy based on hydrogen peroxide photolysis
for non-surgical treatment of moderate to severe periodontitis: a randomized
controlled trial
VL - 7
ID - 13664
ER -
TY - JOUR
AB - AIM: Borinic acid quinoline esters are a recently-identified class of new
antibacterial and anti-inflammatory compounds known to inhibit osteoclastic bone
resorption. They have proposed to have osteostimulative properties by causing
osteoblast differentiation in vivo and in vitro. The purpose of this double-masked,
randomized, controlled clinical trial was to evaluate the effects of the
subgingival delivery of boric acid gel as an adjunct to scaling and root planing
(SRP) on clinical and radiographic parameters, and compare this method with SRP
plus placebo gel alone in chronic periodontitis (CP) patients. METHODS: Thirty-nine
systemically-healthy patients with CP were included in the present study. They were
divided into two groups: (a) SRP + 0.75% boric acid gel (BA group); and (b) SRP +
placebo gel (placebo group). At baseline, 3 and 6 months after treatment, clinical
measurements, including plaque index, modified sulcus bleeding index, probing depth
(PD), clinical attachment level (CAL), intrabony defect depth, and percentage
change in radiographic defect depth reduction (DDR%) as radiographic parameters
were assessed. RESULTS: The mean PD reduction and mean CAL gain were greater in the
BA group than the placebo group at 3 and 6 months. A significantly greater mean
percentage of radiographic DDR% was found in the BA group (36.97±3.47%) compared to
the placebo group (2.88±0.89%) after 6 months. CONCLUSION: BA as an adjunct to SRP
can provide a new insight into therapeutic strategies for the management of CP, but
further clinical evaluations are needed.
AN - rayyan-563560267
AU - Kanoriya, D.
AU - Singhal, S.
AU - Garg, V.
AU - Pradeep, A. R.
AU - Garg, S.
AU - Kumar, A.
DO - 10.1111/jicd.12271
IS - 1
KW - boric acid
controlled study
dental scaling
diagnostic imaging
female
gel
gingiva bleeding
human
India
male
periodontal disease
periodontal index
periodontal pocket
plaque index
procedures
root planing
treatment outcome
LA - English
PY - 2018
SN - 2041-1626
ST - Clinical efficacy of subgingivally-delivered 0.75% boric acid gel as an
adjunct to mechanotherapy in chronic periodontitis: A randomized, controlled
clinical trial
TI - Clinical efficacy of subgingivally-delivered 0.75% boric acid gel as an
adjunct to mechanotherapy in chronic periodontitis: A randomized, controlled
clinical trial
VL - 9
ID - 13641
ER -
TY - JOUR
AB - Infection induced immune responses cause extensive bone destruction in
periodontitis. We previously reported that TNF-alpha converting enzyme (TACE) play
a role in soluble RANKL and soluble TNF-alpha cleavage from activated lymphocytes
in periodontitis, and these soluble osteoclastogenic cytokines induce osteoclast
activation from distant site. Interferon-gamma is known as anti-osteoclastogenic
cytokine produced from activated T cells, but little is known about the post-
transcriptive modification, especially in inflamed tissue. We hypothesized that
TACE might modify interferon-gamma and attenuate anti-osteoclastogenic activity.
Recombinant interferon-gamma is incubated with intact or heat-inactivated
recombinant TACE, electrophoresed in SDS-PAGE gel, and silver stain was done. In
addition, the interferon-gamma concentrations of above samples are measured with
ELISA. Recombinant TACE is added into the supernatant of activated mouse
splenocyte, and measured interferon-gamma concentration. Silver stain revealed that
not heat-inactivated but intact recombinant TACE reduced the 16 kDa band of
recombinant interferon-gamma. ELISA also showed the reduction of interferon-gamma
concentration by the incubation with recombinant TACE. These data suggest that,
TACE might degradate interferon-gamma and attenuate anti-osteoclastogenic activity
of interferon-gamma produced from activated T cells in periodontitis.
AN - rayyan-563560553
AU - Kanzaki, H.
AU - Chiba, M.
AU - Suzuki, M.
AU - Taubman, M.
IS - 1
KW - tumor necrosis factor alpha converting enzyme
gamma interferon
recombinant gamma interferon
cytokine
periodontitis
heat
T lymphocyte
silver staining
lymphocyte
tissues
bone destruction
immune response
infection
spleen cell
osteoclast activity
mouse
supernatant
LA - English
PY - 2012
SN - 0022-1767
ST - TNF-alpha converting enzyme degradates interferon-gamma
T2 - J. Immunol.
TI - TNF-alpha converting enzyme degradates interferon-gamma
VL - 188
ID - 13927
ER -
TY - JOUR
AN - rayyan-563559682
AU - Kao, J. H.
DO - 10.1016/j.jfma.2023.08.003
IS - 9
KW - chlorhexidine
chloride
gel
allograft
aortic graft
artificial ventilation
auriculocondylar syndrome
bone atrophy
cerebrovascular accident
chloride blood level
cognitive stimulus therapy
cognitive therapy
consultation
craniofacial malformation
editorial
emergency ward
esophagus atresia
home rehabilitation
human
in-hospital mortality
induced hypothermia
institutionalization
liver cirrhosis
lung cancer
medical research
molecular dynamics
neutrophil lymphocyte ratio
out of hospital cardiac arrest
parental attitude
rehabilitation care
risk factor
SARS-CoV-2 Omicron
schizophrenia
subacute care
thoracoscopy
trachea surgery
transjugular intrahepatic portosystemic shunt
ventilator weaning
LA - English
PY - 2023
SN - ["1876-0821", "0929-6646"]
SP - 815-818
ST - Highlights
T2 - J. Formos. Med. Assoc.
TI - Highlights
VL - 122
ID - 13056
ER -
TY - JOUR
AB - Objectives: To evaluate the potential benefits of local application of
Thymoquinone gel as an adjunctive to scaling and root planing (SRP) in subjects
with chronic periodontitis. Material and methods: Twenty subjects with 40 test
sites were selected according to inclusion and exclusion criteria. They were
further divided into 2 groups. Group I comprised of study subjects (Thymoquinone in
addition to SRP) and Group II comprised of control subjects (only SRP). Clinical
parameters such as Plaque Index (PI), Gingival Index (GI), Probing Pocket Depth
(PPD), Relative Attachment Level (RAL), were monitored at baseline and 6 weeks post
operatively. Alkaline phosphatase (ALP) levels in gingival crevicular fluid (GCF)
were evaluated at baseline and 6 weeks post operatively using microcapillaries. In
addition antimicrobial efficacy of Thymoquinone was evaluated against 3 bacteria
using antimicrobial strains. Results: Statistically highly significant reduction
was observed in PI, GI and PPD, rise in RAL and GCF ALP level in both the groups at
6 weeks from baseline. On comparison between Group I and Group II, former
demonstrated statistically significant reduction in PPD, GCF-ALP levels and rise in
RAL but statistically no significant differences were observed in PI and GI at 6
weeks. On microbiological assessment of 0.2% Thymoquinone gel, it was observed to
be sensitive against P. gingivalis, A. actinomycetemcomitans and P. intermedia.
Conclusion: Significant changes in clinical and biochemical parameters were
achieved in the current study. Hence, it is concluded that intracrevicular
application of 0.2% Thymoquinone gel could be a beneficial adjunct to SRP in
treating chronic periodontitis.
AN - rayyan-563560235
AU - Kapil, H.
AU - Suresh, D. K.
AU - Bathla, S. C.
AU - Arora, K. S.
DO - 10.1016/j.sdentj.2018.06.001
IS - 4
thymoquinone
adult
article
bacterial strain
clinical article
controlled study
dental scaling
drug efficacy
female
gel
gingival index
human
in vitro study
male
nonhuman
periodontitis
plaque index
relative attachment level
root planing
LA - English
PY - 2018
SN - 1013-9052
SP - 348-354
ST - Assessment of clinical efficacy of locally delivered 0.2% Thymoquinone gel in
the treatment of periodontitis
T2 - Saudi Dent. J.
TI - Assessment of clinical efficacy of locally delivered 0.2% Thymoquinone gel in
VL - 30
ID - 13609
ER -
TY - JOUR
AB - Attachment of bacterial cells to host tissue is usually a prerequisite to
colonisation and pathogenesis. Surface-associated bacteria often form tightly-
packed, exopolysaccharide-encased colonies known as biofilms. Biofilms play a role
in the pathogenesis of dental caries, periodontitis, infective endocarditis, cystic
fibrosis pneumonia, prostatitis, osteomyelitis, otitis media, infectious kidney
stones and other chronic infections. In addition, biofilms that form on indwelling
catheters are responsible for a majority of hospital-acquired bloodstream, eye,
ear, nose, throat and urinary tract infections; and biofilms that form on
permanently implanted medical devices, such as artificial heart valves and
prosthetic joints, are a major cause of device failure. Biofilms are notorious for
their resistance to conventional antimicrobial agents. The role played by biofilms
in human disease, combined with the importance of biofilms in industry, agriculture
and biotechnology, has led to an exponential growth in the number of publications
related to biofilms in recent years, and a concomitant growth in the number of
biofilm-related patents. This review describes the current status of research on
pathogenic biofilms with an emphasis on discoveries that have been the subjects of
recent therapeutic patents. © 2005 Ashley Publications Ltd.
AN - rayyan-563560784
AU - Kaplan, J. B.
DO - 10.1517/13543776.15.8.955
IS - 8
KW - 2 heptyl 3 hydroxy 4 quinolone
2 methyl 2,3,3,4 tetrahydroxytetrahydrofuran
3 (1' bromohexyl) 5 dibromomethylene 2(5h) furanone
3 oxo(2 aminocyclohexanone)
3 oxo(2 aminocyclopentanol)
antibiotic agent
benzalkonium
cerulenin
chlorhexidine
ciprofloxacin
dispersin b
fatty acid synthase inhibitor
furanone 56
furanone C 30
furanone derivative
glycosidase
Haemophilus influenzae vaccine
isoniazid
lactone derivative
lysostaphin
macrogol
minocycline
n (3 oxododecanoyl)homoserine lactone
n butanoylhomoserine lactone
quinolone derivative
rifampicin
Staphylococcus vaccine
sulfadiazine silver
triclosan
unclassified drug
unindexed drug
bacterial infection
bacterial virulence
biofilm
catheter
disease transmission
drug efficacy
drug structure
fatty acid synthesis
hydrogel
infection control
infection risk
coating (procedure)
molecular mechanics
nonhuman
review
LA - English
PY - 2005
SN - 1354-3776
SP - 955-965
ST - Methods for the treatment and prevention of bacterial biofilms
T2 - Expert Opin. Ther. Pat.
TI - Methods for the treatment and prevention of bacterial biofilms
VL - 15
ID - 14158
ER -
TY - JOUR
AB - Periodontitis, a disease involving supportive structures of the teeth
prevails in all groups, ethnicities, races and both genders. It is a localised
inflammatory response caused by bacterial infection of a periodontal pocket
associated with subgingival plaque. Periodontal diseases include conditions such as
chronic periodontitis, aggressive periodontitis and necrotizing periodontitis.
Aggressive forms of periodontitis can be localized or generalized. Antibacterial
agents have been used effectively in the management of periodontal infection. The
effectiveness of mechanical debridement of plaque and repeated topical and systemic
administration of antibacterial agents are limited due to the lack of accessibility
to periodontopathic organisms in the periodontal pocket. Systemic administration of
drugs leads to therapeutic concentrations at the site of infection, but for short
periods of time, forcing repeated dosing for longer periods. Local delivery of
antimicrobials has been investigated for the possibility of overcoming the
limitations of conventional therapy. The use of sustained release formulations to
deliver antibacterials to the site of infection (periodontal pocket) is gaining
interest. These products provide a long-term, effective treatment at the site of
infection at much smaller doses. This review approaches the main delivery systems
for the administration of drugs to the periodontal pocket, their usefulness, as
well as the advancement of these systems effectiveness in the periodontal therapy.
AN - rayyan-563560473
AU - Kaplish, V.
AU - Walia, M. K.
AU - Kumar, S. L. H.
IS - 2
antibiotic agent
chlorhexidine
doxorubicin
doxycycline hyclate
immunoliposome
lidocaine
metronidazole
nanoparticle
ornidazole
tetracycline
triclosan
article
drug efficacy
drug release
fiber
film
gel
gingivitis
human
liposomal delivery
periodontal pocket
tooth plaque
vesicular liposomal system
periostat
LA - English
PY - 2013
SN - 2229-5402
SP - 39-49
ST - Local drug delivery systems in the treatment of periodontitis: A review
T2 - Pharmacophore
TI - Local drug delivery systems in the treatment of periodontitis: A review
VL - 4
ID - 13847
ER -
TY - GEN
AB - Este estudo teve o objetivo de comparar os efeitos da biomodificação
radicular por ácido cítrico associado à tetraciclina (AC) ou terapia fotodinâmica
antimicrobiana (aPDT) no recobrimento de recessões gengivais pela técnica do
enxerto de tecido conjuntivo subepitelial (ETCS). Para o estudo paralelo foram
selecionados 60 sítios em 17 pacientes com recessões de classe I e II de Miller de
2 a 5 mm, múltiplas e isoladas, as quais foram divididas em 3 grupos: grupo
controle (C) - apenas raspagem, grupo AC raspagem e, aplicação de gel de ácido
cítrico associado à tetraciclina (90s) e o grupo aPDT - raspagem e aplicação da
terapia fotodinâmica antimicrobiana (Azul de toluidina O 100µg/ml + laser
vermelho). Os parâmetros clínicos profundidade de sondagem (PS), nível clínico de
inserção (NCI), altura da recessão (AR), largura mucosa ceratinizada (LMC),
espessura de mucosa ceratinizada (EMC), índice de sangramento à sondagem (ISS),
índice de placa (IPI) e porcentagem de recobrimento radicular (%REC) foram
avaliados por um examinador cego e calibrado no baseline e 3, 6 e 12 meses
de pós-operatório. Avaliou-se a hiperestesia dentinária (HIPER) e a percepção
estética (EST) do paciente através de escala analógica visual no baseline e
após 7 e 14 dias e 1, 3, 6 e 12 meses. A análise estatística dos dados de NCI foi
feita pelo teste ANOVA complementado por Tukey. O teste de Friedman complementado
por Wilcoxon foi aplicado para análise intra-grupos. O teste de Kruskal-Wallis foi
aplicado para as diferenças entre os grupos, complementado por comparações
múltiplas entre os três grupos. Para a %REC foi realizado o teste de Kruskal-Wallis
complementado por Dunnet (p<0,05). Observou-se ganho do NCI em todos os grupos, mas
este ganho foi maior para os grupos AC (0,55±1,68) e aPDT (0,80±2,11) em relação ao
C (2,50±1,99) (p<0,05). Houve redução na AR em todos os grupos, porém o grupo AC
(0,40±0,62) teve maior redução quando comparado C (1,15±1,04) (p<0,05). Houve
aumento na LMC em todos os grupos e aumento na EMC também em todos os grupos, sendo
que a EMC nos grupos aPDT (2,80±0,733) e AC (2,33±0,60) foram iguais com melhores
resultados que o C (1,99±0,65) (p<0,05). Para a PS não foram observadas diferenças
significantes entre os grupos e nem entre os períodos (p>0,05). A %REC foi maior
nos grupos AC (82%±30%) e aPDT (82%±28%) do que no grupo C (58%±40%) (p<0,05). De
maneira geral C, AC e aPDT foram semelhantes entre si e entre eles ao longo do
tempo para o ISS e IPI (p>0,05). Houve redução significante da HIPER ao longo do
tempo e entre os grupos, sendo que em AC (1,20±2,23) e aPDT (0,70±1,15) a
diminuição da sensibilidade foi maior do que em C (2,63±2,22) (p<0,05). Houve
melhora na EST ao longo do tempo e para o grupo AC (9,40±0,96) foi maior do que o C
(8,58±1,07) (p<0,05), sendo que o grupo aPDT foi igual ao C. Concluiu-se que o uso
de biomodificadores radiculares, como o AC e aPDT favorecem o recobrimento de
recessões, resultando em redução da hipersensibilidade dentinária, maior
porcentagem de recobrimento radicular e mais sítios com recobrimento completo,
mantendo os resultados a longo prazo. (AU)
The aim of this study was to compare root biomodification by a combination of
citric acid with tetracycline (CA) or antimicrobial photodynamic therapy (aPDT) on
root coverage by subepithelial connective tissue graft (SCTG). Sixty sites with
Miller's class I or II recessions were divided in three groups: Control (C)
scaling only, CA scaling and root conditioning with a combination of citric acid
and tetracycline (gel 90s), aPDT scaling and antimicrobial photodynamic therapy
(toluidine blue O 100 µg/ml and red laser). Periodontal clinical parameters as
probing depth (PD), clinical attachment level (CAL), recession height (RH),
keratinized mucosa height (KMH), keratinized mucosa width (KMW), bleeding on
probing (BOP), plaque index (PI) and percentage of root coverage (%RC) were
evaluated by a blinded calibrated examiner at baseline, 3, 6, 12 months. Dentinal
hyperestesia (HYPER) and patient esthetic perception (EST) were recorded in a
visual analogic scale at baseline, 7 and 14 days, 1, 3, 6,and 12 months.
Statistical analysis of CAL values was done with ANOVA complemented by Tukey.
Friedman's complemented by Wilcoxon's test evaluated intragroup data, while
Kruskal-Wallis was applied for intergroup data. Comparison for %RC was done by
Kruskal-Wallis complemented by Dunnet (p<0.05). Reduction in CAL was observed in
all groups, with higher numbers for CA (0.55±1.68) and aPDT (0.80±2.11) in relation
to C (2.50±1.99) (p<0.05). A higher reduction in RH was observed for CA (0.40±0.62)
compared to C (1.15±1.04) (p<0.05). There was an improvement of KMH and KMW for all
groups, but with higher values of KMW for aPDT (2.80±0.733) and CA (2.33±0.60) in
relation to C (1.99±0.65) (p<0.05). There were no differences for PD (p>0.05).
There was a significant higher %RC for CA (82%±30%) and aPDT (82%±28%) in relation
to C (58%±40%) (p<0.05). In general, BOP and PI were similar for all groups and
periods (p>0.05). There was a significant reduction in hyperestesia along time, but
for CA (1.20±2.23) and aPDT (0.70±1.15) the reduction was higher than C (2.63±2.22)
(p<0.05). Esthetic perception was improved along time with higher values for CA
(9.40±0.96) than C (9.40±0.96) (p<0.05). In conclusion, root biomodification agents
as CA and aPDT favored recession coverage by STCG, resulting in reduction of dentin
hypersensitivity, higher percentage of root coverage and more sites with total
coverage. Additionally, these results had a long-term stability. (AU)
AN - rayyan-563559881
AU - Karam, Paula Stephania Brandão Hage
KW - Condicionamento ácido
Dental scaling
Dentin hypersensitivity
Descontaminação
Fotoquimioterapia
Gingival recession
Hiperestesia dentinária
Photochemotherapy
Recobrimento radicular
Tooth demineralization
LA - pt
PY - 2017
SP - 125-125
ST - Avaliação do recobrimento radicular pela técnica de enxerto conjuntivo
subepitelial e condicionamento radicular com ácido cítrico associado à tetraciclina
ou terapia fotodinâmica antimicrobiana - ensaio clínico randomizado
TI - Avaliação do recobrimento radicular pela técnica de enxerto conjuntivo
subepitelial e condicionamento radicular com ácido cítrico associado à tetraciclina
ou terapia fotodinâmica antimicrobiana - ensaio clínico randomizado
UR - http://www.teses.usp.br/teses/disponiveis/25/25146/tde-21112017-222724/
publico/PaulaStephaniaBrandaoHageKaram_Rev.pdf
ID - 13255
ER -
TY - JOUR
AB - Despite reports on the occurrence of Granulicatella adiacens in infective
endocarditis, few mechanistic studies on its virulence characteristics or
pathogenicity are available. Proteins secreted by this species may act as
determinants of host-microbe interaction and play a role in virulence. Our aim in
this study was to investigate and functionally characterize the secretome of G.
adiacens. Proteins in the secretome preparation were digested by trypsin and
applied to nanoLC-ESI-MS/MS. By using a combined mass spectrometry and
bioinformatics approach, we identified 101 proteins. Bioinformatics tools
predicting subcellular localization revealed that 18 of the secreted proteins
possessed signal sequence. More than 20% of the secretome proteins were putative
virulence proteins including serine protease, superoxide dismutase, aminopeptidase,
molecular chaperone DnaK, and thioredoxin. Ribosomal proteins, molecular
chaperones, and glycolytic enzymes, together known as “moonlighting proteins,”
comprised fifth of the secretome proteins. By Gene Ontology analysis, more than 60
proteins of the secretome were grouped in biological processes or molecular
functions. KEGG pathway analysis disclosed that the secretome consisted of enzymes
involved in biosynthesis of antibiotics. Cytokine profiling revealed that secreted
proteins stimulated key cytokines, such as IL-1β, MCP-1, TNF-α, and RANTES from
human PBMCs. In summary, the results from the current investigation of the G.
adiacens secretome provide a basis for understanding possible pathogenic mechanisms
of G. adiacens.
AN - rayyan-563560220
AU - Karched, M.
AU - Bhardwaj, R. G.
AU - Tiss, A.
AU - Asikainen, S.
DO - 10.3389/fcimb.2019.00104
KW - chromatograph
liquid chromatograph
mass spectrometer
acyl carrier protein
aminopeptidase
antibiotic agent
CCL1 chemokine
cell protein
chaperone
glycolytic enzyme
interleukin 1beta
interleukin 6
macrophage inflammatory protein 1beta
phosphoglycerate kinase
protein DnaK
RANTES
ribosome protein
secretome
thioredoxin
trichloroacetic acid
unclassified drug
amino acid sequence
article
bacterial strain
bacterial viability
bacterial virulence
bioinformatics
biosynthesis
cell lysate
cellular distribution
chemoluminescence
controlled study
cytokine production
gene ontology
Granulicatella adiacens
human
human cell
isoelectric point
nonhuman
protein analysis
protein secretion
proteomics
Western blotting
Agilent 1100
LTQ-FT Ultra
LA - English
PY - 2019
SN - 2235-2988
ST - Proteomic Analysis and Virulence Assessment of Granulicatella adiacens
Secretome
TI - Proteomic Analysis and Virulence Assessment of Granulicatella adiacens
Secretome
VL - 9
ID - 13594
ER -
TY - JOUR
AB - Introduction: Periodontal pocket is a pathologically deepening of gingival
sulcus along with subgingival contamination of hard and soft tissues. Scaling and
root planning is an effective treatment in addition to supra gingival plaque
managing. Many studies show that the adjunctive use of sub gingival antimicrobial
agents with scaling and root planning resulted in improvement clinically and
microbiologically. Aim: To determine if scaling and root planning alone or in
combination with 0.2% chlorhexidine and 3% hydrogen peroxide gel (Glucosite gel)
have a significant effect on total viable count of anaerobic bacteria and bleeding
on probing. Materials and methods: A total 136 periodontal pockets of 20 patients
of both sexes aged from 35 to 50 years which have at least two periodontal pockets
ranged from 5-6 mm on each side participated in this study, treated with split
mouth technique. One side treated via scaling and root planning only, while the
other side combined with glucosite gel. Bleeding on probing and total viable
anaerobic count was recorded at day zero and after 4 weeks. With exclusion patients
who were pregnant, smokers, had systemic diseases or who on orthodontic or
periodontal treatment. SPSS for windows was used for data analysis. Results:
Glucosite gel adjunctive to scaling and root planning reduced significantly
bleeding on probing and subgingival viable anaerobic bacteria in comparison to
scaling and root planning alone. Conclusion: Applications of glucosite gel
subgingivally in combination with scaling and root planning have additional effects
on clinical and microbiological periodontal outcomes.
AN - rayyan-563562436
AU - Kareem, A.
AU - Ghafory, B.
AU - Al-Mizraqchi, A. S.
IS - 1
PY - 2020
SN - ["2347-2545", "2347-2367"]
SP - 125-131
ST - Efficacy of Intra Periodontal Pocket Application with Combined Chlorhexidine
and Hydrogen Peroxide on the Bleeding on Probing and Anaerobic Bacterial Viable
Count
T2 - JOURNAL OF RESEARCH IN MEDICAL AND DENTAL SCIENCE
TI - Efficacy of Intra Periodontal Pocket Application with Combined Chlorhexidine
and Hydrogen Peroxide on the Bleeding on Probing and Anaerobic Bacterial Viable
Count
VL - 8
ID - 15810
ER -
TY - JOUR
AB - The purpose of this study was to investigate the antibacterial effects of a
short-term topical application of ornidazole on anaerobic microorganisms, The
antibacterial properties of such materials against organisms at infected primary
root canals have not been well documented. Twenty infected primary molars in this
study were treated using ornidazole (Biteral, Roche), The bacterial contents of the
roots were collected with sterile paper points before the application. Freshly
mixed ornidazole and sterile saline were placed into the root canals, After 1 week,
the bacterial contents of the root canals were collected again. Microbiological
analyses were made, Based on our results, it appears that the antibacterial
activity of ornidazole caused significant changes in rates of microorganisms
(94.53% reduction), Copyright (C) 2001 S. Karger AG, Basel.
AN - rayyan-563562420
AU - Kargul, B.
AU - Kadir, T.
DO - 10.1159/000063222
IS - 3
PY - 2001
SN - ["0009-3157", "1421-9794"]
SP - 203-207
ST - The antibacterial effects of ornidazole on primary molars with infected pulps
T2 - CHEMOTHERAPY
TI - The antibacterial effects of ornidazole on primary molars with infected pulps
VL - 47
Y2 - 5
ID - 15794
ER -
TY - JOUR
AB - Purpose: To formulate carbomer gel to localize and target drug action in
periodontal pockets. Methods: Diclofenac sodium (DS, anti-inflammatory) and
metronidazole hydrochloride (MH, antibacterial) were loaded in gelatin microspheres
using glutaraldehyde cross-linking. The microspheres were evaluated for drug
loading, entrapment and encapsulation efficiency, particle size, drug release as
well as by scanning electron microscopy (SEM) and differential scanning calorimetry
(DSC). The microspheres were incorporated into carbomer gel and evaluated for drug
release. Results: Loading, entrapment and encapsulation efficiencies of DS in the
microsphere were 23.4, 93.6, and 74.9 w/w%, respectively, while for MH the values
were 21.5, 86.0 and 73.1 % w/w, respectively. Mean particle size of unloaded
microspheres, DS- and MH-loaded microspheres was 33.5, 67.8 and 51.4 μm,
respectively. SEM showed spherical geometry of microspheres while DSC indicated the
amorphous nature of t entrapped DS and MH. Sustained release of DS and MH over a 4-
h period from the microspheres and gel was achieved. Conclusion: Carbomer gel
loaded with microspheres of diclofenac and metronidazole is a potential localized
delivery system for the treatment inflammation and infection in periodontal
pockets. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin
City, 300001 Nigeria.
AN - rayyan-563560564
AU - Karthikeyan, K.
AU - Durgadevi, R.
AU - Saravanan, K.
AU - Shivsankar, K.
AU - Usha, S.
AU - Saravanan, M.
DO - 10.4314/tjpr.v11i3.1
IS - 3
KW - adhesive agent
carbomer
diclofenac
gelatin microsphere
glutaraldehyde
metronidazole
microsphere
unclassified drug
article
cross linking
gel
in vitro study
microencapsulation
particle size
periodontal disease
physical chemistry
LA - English
PY - 2012
SN - ["1596-9827", "1596-5996"]
SP - 335-343
ST - Formulation of bioadhesive carbomer gel incorporating drug-loaded gelatin
microspheres for periodontal therapy
T2 - Trop. J. Pharm. Res.
TI - Formulation of bioadhesive carbomer gel incorporating drug-loaded gelatin
microspheres for periodontal therapy
VL - 11
ID - 13938
ER -
TY - JOUR
AN - rayyan-563561210
AU - Kaslick, R. S.
AU - Shapiro, W. B.
AU - Chasens, A. I.
DO - 10.1902/jop.1975.46.4.230
IS - 4
KW - unclassified drug
carbamide peroxide
article
gingivitis
therapy
tooth plaque
LA - English
PY - 1975
SN - 0022-3492
SP - 230-232
ST - Studies on the effects of a urea peroxide gel on plaque formation and
gingivitis
TI - Studies on the effects of a urea peroxide gel on plaque formation and
gingivitis
VL - 46
ID - 14584
ER -
TY - JOUR
AB - Objective: The aim of this study was to develop a bioadhesive gel of
gatifloxacin for the treatment of periodontal diseases. Methods: Periodontal gels
of gatifloxacin were prepared using different hydrophilic polymers such as carbopol
940 (CP 940), carboxymethyl cellulose (CMC) and hydroxypropylmethyl cellulose
(HPMC) in varied concentrations, either alone or as a combination. The prepared
gels were evaluated for their physical appearance, pH, drug content, viscosity,
bioadhesiveness and in vitro drug release profile. The influence of the type and
the concentration of polymer on the drug release as well as on viscosity and
mucoadhesiveness of prepared gels were investigated. Results: The prepared gels
showed acceptable physical properties concerning color, homogeneity, consistency,
spreadability, and pH value. Using different polymer types at different
concentrations, as well as different polymer combinations, play a significant role
in the variation of overall characteristics of formulations. Increasing the
concentration of polymer increased the viscosity as well as mucoadhesion, and
reduced drug release rate. Formulation F 11 (1 % CP 940 and 5 % CMC) was selected
as the formula of choice based on the data of various evaluation parameters such as
pH, drug content, viscosity, spreadability and bioadhesion as well as its ability
to show a prolonged drug release pattern. Conclusion: The obtained results show
that a bioadhesive periodontal gel of gatifloxacin can be prepared using
hydrophilic polymers, and by using a combination of polymers the viscosity,
mucoadhesiveness, spreadability and release behavior can be optimized.
AN - rayyan-563560318
AU - Kassab, H. J.
AU - Thomas, L. M.
AU - Jabir, S. A.
DO - 10.22159/ijap.2017v9i3.17056
IS - 3
KW - biologic glue
carbopol 940
gatifloxacin
article
color
consistency
controlled study
correlational study
gel
homogeneity
hydrophilicity
in vitro study
mucoadhesion
periodontal disease
pH
physical parameters
spreadability
viscosity
LA - English
PY - 2017
SN - 0975-7058
SP - 31-36
ST - Development and physical characterization of a periodontal bioadhesive gel of
gatifloxacin
TI - Development and physical characterization of a periodontal bioadhesive gel of
gatifloxacin
VL - 9
ID - 13692
ER -
TY - JOUR
AB - In situ gelling formulations allow easy application to the target area.
Gelation is induced by physiological stimuli at the site of application where the
formula attains semisolid properties and exerts sustained drug release. In situ
gelling formulations containing either 3% meloxicam (Mx) or 2% minocycline HCl (MH)
were prepared for local application into the periodontal pockets. Gel formulations
were based on the thermosensitive Pluronic® (Pl) and the pH-sensitive Carbopol® (C)
polymers. C gels were prepared in combination with HPMC (H) to decrease its
acidity. The total percent drug released from Pl formulae was 21.72% after 1 week
for Mx and 85% after 3 days for MH. Their release kinetics data indicated anomalous
non-Fickian behavior that could be controlled by both diffusion and chain
relaxation. Addition of MH to C/H gels (1:2.5) resulted in liquefaction, followed
by drug precipitation. Regarding C/H gel containing Mx, it showed a prolonged
release rate up to 7 days with an initial burst effect; the kinetics data revealed
Fickian-diffusion mechanism. The in vitro antibacterial activity studies for MH gel
in Pl revealed that the drug released exceeded the minimum inhibitory concentration
(MIC) of MH against Staphylococcus aureus ATCC 6538; placebo gel showed no effect
on the microorganism. Clinical evaluation of Pl gels containing either Mx or MH
showed significant improvement in chronic periodontitis patients, manifested by
decrease in pocket depth and gingival index and increase in bone density. © 2014
American Association of Pharmaceutical Scientists.
AN - rayyan-563560451
AU - Kassem, A. A.
AU - Ismail, F. A.
AU - Naggar, V. F.
AU - Aboulmagd, E.
DO - 10.1208/s12249-014-0118-7
IS - 4
KW - carbomer
meloxicam
minocycline
placebo
poloxamer
acidity
adult
article
bone density
clinical evaluation
drug diffusion
drug distribution
drug effect
drug formulation
drug solution
female
follow up
gel
heat sensitivity
human
in situ gel system
in vitro study
kinetics
liquefaction
local therapy
micelle
periodontal pocket
pH
priority journal
viscosity
LA - English
PY - 2014
SN - 1530-9932
SP - 1021-1028
ST - Comparative study to investigate the effect of meloxicam or minocycline HCl
in situ gel system on local treatment of periodontal pockets
TI - Comparative study to investigate the effect of meloxicam or minocycline HCl
VL - 15
ID - 13825
ER -
TY - COMP
AB - In situ gelling formulations allow easy application to the target area.
Gelation is induced by physiological stimuli at the site of application where the
formula attains semisolid properties and exerts sustained drug release. In situ
gelling formulations containing either 3% meloxicam (Mx) or 2% minocycline HCl (MH)
were prepared for local application into the periodontal pockets. Gel formulations
were based on the thermosensitive Pluronic(®) (Pl) and the pH-sensitive Carbopol(®)
(C) polymers. C gels were prepared in combination with HPMC (H) to decrease its
acidity. The total percent drug released from Pl formulae was 21.72% after 1 week
for Mx and 85% after 3 days for MH. Their release kinetics data indicated anomalous
non-Fickian behavior that could be controlled by both diffusion and chain
relaxation. Addition of MH to C/H gels (1:2.5) resulted in liquefaction, followed
by drug precipitation. Regarding C/H gel containing Mx, it showed a prolonged
release rate up to 7 days with an initial burst effect; the kinetics data revealed
Fickian-diffusion mechanism. The in vitro antibacterial activity studies for MH gel
in Pl revealed that the drug released exceeded the minimum inhibitory concentration
(MIC) of MH against Staphylococcus aureus ATCC 6538; placebo gel showed no effect
on the microorganism. Clinical evaluation of Pl gels containing either Mx or MH
showed significant improvement in chronic periodontitis patients, manifested by
decrease in pocket depth and gingival index and increase in bone density.
AN - rayyan-563561277
AU - Kassem, A. A.
AU - Ismail, F. A.
AU - Naggar, V. F.
AU - Aboulmagd, E.
CY - United States
DO - 10.1208/s12249-014-0118-7
ET - 4
J2 - AAPS PharmSciTech
KW - Adult
Anti-Bacterial Agents/chemistry/pharmacology
Chemistry, Pharmaceutical/methods
Delayed-Action Preparations/chemistry/pharmacology
Diffusion
Drug Liberation
Female
Gels/*chemistry/*pharmacology
Humans
Kinetics
Meloxicam
Minocycline/*chemistry/*pharmacology
Periodontal Pocket/*drug therapy
Polymers/chemistry/pharmacology
Staphylococcus aureus/drug effects
Thiazines/*chemistry/*pharmacology
Thiazoles/*chemistry/*pharmacology
Young Adult
LA - eng
N1 - Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University,
Alexandria, Egypt, abeerkassem2002@gmail.com.
PY - 2014
SP - 1021-8
ST - Comparative study to investigate the effect of meloxicam or minocycline HCl
TI - Comparative study to investigate the effect of meloxicam or minocycline HCl
VL - 15
Y2 - 8
ID - 14651
ER -
TY - JOUR
AB - Introduction: Bacterial flora, which makes dental plaque, is the primary and
most responsible factor in the etiology of periodontal disease and oral
inflammation. Bacteria, biofilm factors become aggressive and cause destruction of
the tissue, either directly through enzymatic reactions and bacterial toxins, or
indirectly inducing inflammatory tissue response. Chemical agents based on
chlorhexidine, triclosan and cetylpipyridinium chloride are effective, but also
aggressive, because they use a low specificity strategy, significantly damaging
most of the bacteria and causing an imbalance of the entire oral ecosystem. Some of
the effective natural extracts used in the oral cavity are avocado oil, manuka oil,
propolis and grape seed extracts. Innovative complex encapsulation technology of
natural extracts allows greater product efficacy, longer releasing of active
substances during the penetration of microcapsules within soft tissues. Purpose:
The purpose of this clinical study was to evaluate and compare the effectiveness of
microcapsulated natural extracts contained in gel in healing of surgical wounds
after open maxillary sinus lift and implantation of dental implants. Materials and
Methods: Ten patients with absolute indications for bilateral sinus lift surgery
(distally toothless jaw or toothless upper jaw with residual bone, 2-4 mm high in
the molar region) were included in the study. All respondents signed an informed
consent for participation in the study. Each patient was scheduled for bilateral
maxillary sinus lifting by using a lateral window technique, followed by PRF
augmentation, xenogenic bone placement, and final placement of two dental implants.
For each patient, single blind criteria was used in the postoperative wound
treatment approach. One side (control site) was postoperatively treated according
to a routine protocol which required patients to treat the wound with a
clorhexidine gel 3 times a day; whereas the other side (test site) required
patients to treat the wound with the gel containing microcapsulated granules based
on natural extracts (GingiNat, LoB Foundation, Paris, France). In order to asses
postoperative healing, patients were asked to fill out a questionnaire which
evaluated postoperative pain, unpleasant feeling, plaque and bacteria accumulation
and subjective rate of delivery by using Likert scale. The same questionnaire was
filled out by a therapist at the check-up screening. Results: No adverse effects in
the recovery period were recorded. The results showed a statistically significant
difference in the postoperative recovery period in the test vs. control group (p
<0.001) in favor of the microcapsulated gel. According to the Likert scale, results
showed that the tested gel showed less plaque accumulation, lack of unpleasantness,
reduced postoperative pain and faster healing (p <0.001) as opposed to the side
where chlorhexidine gel was used. Conclusion: The results of this clinical study
showed significantly improved healing of surgical wounds and a stronger analgesic
effect after application of microcapsulated granules with natural extracts compared
to standard chlorhexidine gel.
AN - rayyan-563560281
AU - Katanec, T.
AU - Gabric, D.
AU - Bago, I.
AU - Katanec, D.
AU - Kotarac-Kneževic, A.
IS - 4
propolis
adult
analgesic activity
avocado
clinical article
conference abstract
controlled study
encapsulation
female
France
grape
human
implantation
informed consent
Likert scale
male
maxillary sinus
microcapsule
mouth inflammation
nonhuman
periodontal disease
plant seed
postoperative pain
questionnaire
sinus floor augmentation
soft tissue
surgical wound
tissue reaction
tooth implant
tooth plaque
visually impaired person
wound care
LA - ["English", "Bosnian"]
PY - 2017
SN - 1846-0410
SP - 355-356
ST - Effect of microincapsulated granules containing natural ingredients on
postoperative granulation after open sinus lift surgery and immediate implantation
of dental implants-split mouth controlled clinical study
T2 - Ucinak Mikrokapsuliranih Granula S Biljnim Ekstraktima U Gelu Na
Postoperativno Cijeljenje Nakon Podizanja DNA Maksilarnoga Sinusa I Imedijatne
Ugradnje Dentalnih Implantata-Split Mouth Controlled Klinicka Studija
TI - Effect of microincapsulated granules containing natural ingredients on
postoperative granulation after open sinus lift surgery and immediate implantation
of dental implants-split mouth controlled clinical study
VL - 51
ID - 13655
ER -
TY - JOUR
AB - Periodontitis is an inflammatory disease of the supporting tissues of the
teeth caused by groups of specific microorganisms. Aggressive forms of
periodontitis can be localized or generalized. The concept that localized problem
sites may be treated by local drug delivery appears attractive as the antimicrobial
agent is delivered within periodontal pockets and the therapy is targeted on
specific pathogenic microorganisms. This review highlights the use of mucoadhesive
polymers in buccal drug delivery. Advantages associated with buccal drug delivery
have rendered this route of administration useful for a variety of drugs.
Characterization of critical properties such as the mucoadhesive strength, drug
content uniformity, and permeation rate represent the major research areas in the
design of buccal films. The present review describe approaches for local prevention
of bacterial infections based on antibiotic-eluting medical devices. © 2010 IRJP.
AN - rayyan-563560534
AU - Katiyar, A.
AU - Prajapati, S. K.
AU - Akhtar, A.
AU - Gautam, A.
AU - Sanjay, V.
IS - 8
KW - 2 hydroxyacid
adhesive agent
antibiotic agent
carbopol 974p
chloroform
metronidazole
plasticizer
polycarbophil
polyglactin
polymer
tetracycline
bacterial infection
drug penetration
gel
hard palate
human
infection prevention
microcapsule
mouth cavity
mouth mucosa
mucoadhesion
passive transport
periodontal pocket
periodontitis
review
LA - English
PY - 2012
SN - 2230-8407
SP - 61-66
ST - Therapeutic strategies for the treatment of periodontitis
T2 - Int. Res. J. Pharm.
TI - Therapeutic strategies for the treatment of periodontitis
VL - 3
ID - 13908
ER -
TY - JOUR
AB - In order to examine the potential role of bacterial collagenases in
periodontal tissue destruction, we recently isolated a gene, prtC, from
Porphyromonas gingivalis ATCC 53977, which expressed collagenase activity (N.
Takahashi, T. Kato, and H. K. Kuramitsu, FEMS Microbiol. Lett. 84:135-138, 1991).
The nucleotide sequence of the gene has been determined, and the deduced amino acid
sequence corresponds to a basic protein of 37.8 kDa. In addition, Southern blot
analysis indicated that the prtC gene is conserved among the three major serotypes
of P. gingivalis. The enzyme has been purified to near homogeneity from Escherichia
coli clone NTS1 following Mono Q anion exchange and sequential gel filtration
chromatography. The molecular mass of the purified enzyme was estimated by sodium
dodecyl sulfate- polyacrylamide gel electrophoresis to be ca. 35 kDa, and the
active enzyme behaved as a dimer following gel filtration chromatography. The
collagenase degraded soluble and reconstituted fibrillar type I collagen, heat-
denatured type I collagen, and azocoll but not gelatin or the synthetic collagenase
substrate 4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-D-Arg. Enzyme activity was
enhanced by Ca2+ and inhibited by EDTA, sulfhydryl-blocking agents, and the
salivary peptide bistatin. Preliminary evidence for the existence of a second
collagenase expressed by strain 53977 was also obtained.
AN - rayyan-563561153
AU - Kato, T.
AU - Takahashi, N.
AU - Kuramitsu, H. K.
DO - 10.1128/jb.174.12.3889-3895.1992
IS - 12
KW - calcium ion
collagen type 1
collagenase
dimer
edetic acid
histatin
amino acid sequence
article
bacterial gene
enzyme activity
enzyme denaturation
enzyme purification
enzyme substrate
nonhuman
nucleotide sequence
Porphyromonas
priority journal
serotype
LA - English
PY - 1992
SN - 0021-9193
SP - 3889-3895
ST - Sequence analysis and characterization of the Porphyromonas gingivalis prtC
gene, which expresses a novel collagenase activity
T2 - J. BACTERIOL.
TI - Sequence analysis and characterization of the Porphyromonas gingivalis prtC
gene, which expresses a novel collagenase activity
VL - 174
ID - 14527
ER -
TY - JOUR
AB - Craniosynostosis is the premature fusion of skull sutures and has a severe
pathological impact on childrens’ life. Mechanical forces are capable of triggering
biological responses in bone cells and regulate osteoblastogenesis in cranial
sutures, leading to premature closure. The mechanosensitive proteins polycystin-1
(PC1) and polycystin-2 (PC2) have been documented to play an important role in
craniofacial proliferation and development. Herein, we investigated the
contribution of PC1 to the pathogenesis of non-syndromic craniosynostosis and the
associated molecular mechanisms. Protein expression of PC1 and PC2 was detected in
bone fragments derived from craniosynostosis patients via immunohistochemistry. To
explore the modulatory role of PC1 in primary cranial suture cells, we further
abrogated the function of PC1 extracellular mechanosensing domain using a specific
anti-PC1 IgPKD1 antibody. Effect of IgPKD1 treatment was evaluated with cell
proliferation and migration assays. Activation of PI3K/AKT/mTOR pathway components
was further detected via Western blot in primary cranial suture cells following
IgPKD1 treatment. PC1 and PC2 are expressed in human tissues of craniosynostosis.
PC1 functional inhibition resulted in elevated proliferation and migration of
primary cranial suture cells. PC1 inhibition also induced activation of AKT,
exhibiting elevated phospho (p)-AKT (Ser473) levels, but not 4EBP1 or p70S6K
activation. Our findings indicate that PC1 may act as a mechanosensing molecule in
cranial sutures by modulating osteoblastic cell proliferation and migration through
the PC1/AKT/mTORC2 cascade with a potential impact on the development of non-
syndromic craniosynostosis.
AN - rayyan-563559868
AU - Katsianou, M. A.
AU - Papavassiliou, K. A.
AU - Gargalionis, A. N.
AU - Agrogiannis, G.
AU - Korkolopoulou, P.
AU - Panagopoulos, D.
AU - Themistocleous, M. S.
AU - Piperi, C.
AU - Basdra, E. K.
AU - Papavassiliou, A. G.
DO - 10.1111/jcmm.17266
IS - 8
KW - chemiluminescence analyzer
culture medium
imaging software
LumiSensor
microscope
actin
antibody
collagenase
immunoglobulin G antibody
mammalian target of rapamycin complex 2
phosphatidylinositol 3 kinase
polycystin 1
polycystin 2
polycystin 2 antibody
reagent
streptomycin
unclassified drug
Akt/mTOR signaling
article
bone development
cell migration
cell proliferation
centrifugation
child
clinical article
controlled study
cranial suture
craniofacial synostosis
densitometry
female
human
immunoreactivity
male
mTOR signaling
osteoblast
osteocyte
preschool child
signal transduction
trigonocephaly
XTT assay
LA - English
PY - 2022
SN - 1582-1838
SP - 2428-2437
ST - Polycystin-1 regulates cell proliferation and migration through AKT/mTORC2
pathway in a human craniosynostosis cell model
T2 - J. Cell. Mol. Med.
TI - Polycystin-1 regulates cell proliferation and migration through AKT/mTORC2
pathway in a human craniosynostosis cell model
VL - 26
ID - 13242
ER -
TY - JOUR
AB - Background: Successful management of periodontitis requires treatment
strategy that integrates therapies addressing both pathogen and host aspects of
disease etiology. To evaluate sub gingivally applied curcumin gel in treatment of
chronic periodontitis based on clinical and biochemical parameters. Materials &
Methods: A randomized, double blind, parallel-group trial was carried out on 30
patients suffering from chronic generalized periodontitis with probing pocket
depth=5mm on at least 4 sites who were then randomly allocated to two groups.
Control group was treated with Scaling and Root Planing (SRP) alone while
experimental group was treated with SRP followed by subgingival application of
curcumin gel. Saliva collection was done and the clinical parameters were recorded
at baseline and follow up periods. Saliva analysis for IL-1β was done by ELISA. The
statistical differences for the intra-group and intergroup measurements were
analyzed by using Mann Whitney test. Spearman’s rank correlation coefficient was
used to examine the relationship between Interleukin - 1β and clinical parameters.
Results: Study elucidated mild adjunctive benefit of curcumin gel in reduction of
gingival inflammation for a limited period of time. Though improvement in other
clinical parameters was also greater in subjects treated with curcumin gel, results
were not statistically different from those treated with SRP alone. None of the
subjects who received curcumin gel experienced any adverse effect. Conclusion:
Within limitations, it can be concluded that single application of curcumin
(turmeric) gel has limited added benefit over scaling and root planing in treatment
of chronic periodontitis.
AN - rayyan-563560208
AU - Kaur, H.
AU - Grover, V.
AU - Malhotra, R.
AU - Gupta, M.
DO - 10.2174/1871526518666180601073422
IS - 2
KW - ELISA kit
biological marker
curcumin
interleukin 1beta
lipoxygenase
adult
aged
aphthous stomatitis
article
clinical article
comparative study
controlled study
dental scaling
female
gel
gingivitis
human
male
mouth hygiene
periodontal pocket
plaque index
root planing
saliva analysis
tooth plaque
LA - English
PY - 2019
SN - ["1875-5852", "1871-5265"]
SP - 171-178
ST - Evaluation of curcumin gel as adjunct to scaling & root planing in management
of periodontitis- randomized clinical & biochemical investigation
T2 - Infect. Disord. Drug Targets
TI - Evaluation of curcumin gel as adjunct to scaling & root planing in management
of periodontitis- randomized clinical & biochemical investigation
VL - 19
ID - 13582
ER -
TY - JOUR
AB - Aloe vera (Aloe barbadensis) is a plant that belongs to the Liliaceae family.
It is called the “plant of immortality" because it can live and bloom without soil.
It has various properties such as immunomodulatory, antiviral, and anti-
inflammatory in nature. Aloe vera is gaining popularity in dentistry because it is
completely natural and has fewer side effects with its use. Products of the plant
are used in the treatment of various ailments. Aloe vera can play a significant
role in dentistry in the treatment of oral lichen planus, recurrent aphthous
stomatitis, radiation-induced oral mucositis, periodontitis, gingivitis. It has
been used in dentistry for its wound-healing property, plaque control, and curing
oral mucosal lesions. The Greek scientists reported Aloe vera as a universal
panacea. The dentists use Aloe vera as an herbal remedy in dentistry. However
future research should be aimed to determine its preparation methods, time of
application, optimal concentration, and its effect on the oral cavity. This paper
gives a review of the uses of this miracle plant and its uses in dentistry.
AN - rayyan-563560082
AU - Kaviya, L.
DO - 10.31838/ijpr/2020.12.04.180
IS - 4
KW - denture
tooth implant
anthraquinone
gel
laxative
lignin
prostaglandin E2
saponin
toothpaste
agar diffusion
Aloe vera
angiogenesis
antifungal activity
aphthous stomatitis
article
breast feeding
cytotoxicity
dental procedure
dentist
dentistry
fibroblast
gingivectomy
gingivitis
growth inhibition
herbal medicine
human
lichen planus
mouth cavity
mouth hygiene
oral mucositis
parenchyma
pathophysiology
periodontitis
plant leaf
pregnancy
Streptococcus pyogenes
tooth brushing
tooth plaque
vascularization
wound healing
xerophyte
LA - English
PY - 2020
SN - 0975-2366
SP - 1192-1195
ST - Aloe vera as an herbal remedy in dentistry
TI - Aloe vera as an herbal remedy in dentistry
VL - 12
ID - 13456
ER -
TY - JOUR
AB - Nanotechnology is considered to be an evolving technology. The effective
usage of nanoparticles in dentistry is to improve oral care and oral hygiene. The
technology helps in modifying the existing dental materials to improve their
quality and stability. On the basis of properties of the nanoparticles, they are
used in the field of dentistry. Nanotechnology is the field of using nanoparticles
which are synthesized naturally and chemically from natural and chemical
substances. The nanoparticles are used in the field of dentistry according to their
physical, chemical and biological properties. The nanoparticles are used according
to the properties they possess and toxicological action. The nanoparticles help in
the dental diagnosis, prevention of disease and preparation of dental materials.
The nanopreparation includes nano-mouthwash, nano-toothpaste, nano-tooth gels,
nano-root canal irrigants. The nano based dental preparation mainly depends on the
antibacterial activity of the nanoparticles. These nano based dental materials are
a modified form of the conventional materials to improve the stability and quality
of the material to promote oral care. Nanomaterials deliver drugs and have curing
capacity on oral diseases. The nanotechnology has been used for future studies
based on their properties. The advances of nanoparticles help the future of
dentistry and new developments of nano-based dental preparations. This advances
helps in maintaining proper oral hygiene. The disadvantage faced by the
nanoparticles is their toxicity on increase in the concentration of nanoparticles.
This review is provided with a detailed overview of the update of nano-based dental
preparation.
AN - rayyan-563560083
AU - Kaviya, N. E.
AU - Roy, A.
DO - 10.31838/ijpr/2020.12.04.181
IS - 4
calcium
calcium carbonate
chlorhexidine
copper oxide nanoparticle
dental material
hypochlorite sodium
mouthwash
nano mouthwash
nano toothpaste
nanocomposite
nanogel
nanomaterial
nanoparticle
silicon
silver
silver nanoparticle
tetracycline
toothpaste
unclassified drug
biofilm
cytotoxicity
dental caries
dentistry
drug quality
drug stability
gingivitis
human
mouth cavity
mouth disease
mouth hygiene
nanochemistry
physical chemistry
review
LA - English
PY - 2020
SN - 0975-2366
SP - 1196-1202
ST - Nano based dental preparation-an update
TI - Nano based dental preparation-an update
VL - 12
ID - 13457
ER -
TY - JOUR
AB - Periodontal disease develops as a result of oral microbiota in dysbiosis,
followed by the growth of periodontal pathogens such as Porphyromonas gingivalis
and Prevotella intermedia. In case of acute symptoms, antibacterial agents and
disinfectants are administered, however the appearance of drug-resistant bacteria
and allergies cause problems. In recent years, studies on the effects of probiotics
have been conducted as an alternative therapy for periodontitis. However, the basic
mechanism of the inhibitory effect of probiotic bacteria on periodontal disease has
not been clearly elucidated. To clarify the antibacterial mechanism of probiotics
against periodontal pathogens, we used Limosilactobacillus (Lactobacillus)
fermentum ALAL020, which showed the strongest antibacterial activity against P.
gingivalis and P. intermedia among 50 screened lactic acid bacteria strains. The
antibacterial substances produced were identified and structurally analyzed. After
neutralizing the MRS liquid culture supernatant of ALAL020 strain, the molecular
weight (m/z) of the main antibacterial substance separated by gel filtration column
chromatography and reverse phase HPLC was 226.131. This low molecular weight
compound was analyzed by LC-MS and disclosed the composition formula C11H18O3N2,
however the molecular structure remained unknown. Then, structural analysis by NMR
revealed C11H18O3N2 as the cyclic dipeptide, “hexahydro-7-hydroxy-3- (2-
methylpropyl) pyrrolo [1,2-a] pyrazine-1,4-dion cyclo (Hyp-Leu) “. Based on the
results of this analysis, cyclo (Hyp-Leu) was chemically synthesized and the
antibacterial activity against P. gingivalis and P. intermedia was measured. The
minimum inhibitory concentration (MIC) was 2.5 g/L and the minimum bactericidal
concentration (MBC) was shown to be less than 5 g/L. In addition, an in vitro
epithelial tissue irritation test at 10 g/L showed no tissue toxicity. So far there
are no reports of this peptide being produced by probiotic bacteria. Furthermore,
antibacterial activity of this cyclic dipeptide against periodontal disease
bacteria has not been confirmed. The results of this study might lead to a
comprehensive understanding of the antibacterial mechanism against periodontal
disease bacteria in future, and are considered applicable for the prevention of
AN - rayyan-563559890
AU - Kawai, T.
AU - Ohshima, T.
AU - Tanaka, T.
AU - Ikawa, S.
AU - Tani, A.
AU - Inazumi, N.
AU - Shin, R.
AU - Itoh, Y.
AU - Meyer, K.
AU - Maeda, N.
DO - 10.3389/fcimb.2022.804334
KW - culture medium
high performance liquid chromatography column
liquid chromatography-mass spectrometer
MRI scanner
spectrometer
dipeptide
article
bacterium culture
chemical structure
controlled study
drug synthesis
dysbiosis
human
human tissue
Lactobacillus fermentum
mass spectrometry
nonhuman
nuclear magnetic resonance imaging
periodontal disease
periodontitis
soybean milk
structure analysis
supernatant
synthesis
LA - English
PY - 2022
SN - 2235-2988
ST - Limosilactobacillus (Lactobacillus) fermentum ALAL020, a Probiotic Candidate
Bacterium, Produces a Cyclic Dipeptide That Suppresses the Periodontal Pathogens
Porphyromonas gingivalis and Prevotella intermedia
TI - Limosilactobacillus (Lactobacillus) fermentum ALAL020, a Probiotic Candidate
Bacterium, Produces a Cyclic Dipeptide That Suppresses the Periodontal Pathogens
Porphyromonas gingivalis and Prevotella intermedia
VL - 12
ID - 13264
ER -
TY - JOUR
AB - The influence of combined use of gel Metrogil Denta and tooth-paste Mexidol
Dent aktiv on processes of peroxide oxidation of lipids and anti-oxidative activity
of mouth fluid in treatment of chronic gingivitis in young persons was
investigated. The corrective influence of combination of these products on free-
radical processes in mouth fluid was shown.
AN - rayyan-563560731
AU - Kazarina, L. N.
AU - Kuzin, V. B.
AU - Ellarian, L. K.
AU - Tepaev, D. V.
IS - 4
KW - metronidazole
mexidol
picoline derivative
toothpaste
adolescent
adult
article
chronic disease
clinical trial
controlled study
drug combination
drug effect
female
gel
gingivitis
human
lipid peroxidation
male
periodontics
treatment outcome
LA - Russian
PY - 2007
SN - 0039-1735
SP - 19-21
ST - Influence of gel Metrogil Denta and curative toothpaste Mexidol Dent activ on
indices of parodontal status and lipid peroxidation in patients with chronic
generalized catarrhal gingivitis
TI - Influence of gel Metrogil Denta and curative toothpaste Mexidol Dent activ on
indices of parodontal status and lipid peroxidation in patients with chronic
generalized catarrhal gingivitis
VL - 86
ID - 14105
ER -
TY - JOUR
AN - rayyan-563561619
AU - Kazeli, K.
AU - Tsamesidis, I.
AU - Theocharidou, A.
AU - Malletzidou, L.
AU - Rhoades, J.
AU - Pouroutzidou, G. K.
AU - Likotrafiti, E.
AU - Chrissafis, K.
AU - Lialiaris, T.
AU - Papadopoulou, L.
AU - Kontonasaki, E.
AU - Lymperaki, E.
DO - 10.3390/ceramics4040045
IS - 4
PY - 2021
SP - 628-651
ST - Synthesis and characterization of novel calcium-silicate nanobioceramics with
magnesium: Effect of heat treatment on biological, physical and chemical properties
T2 - Ceramics
TI - Synthesis and characterization of novel calcium-silicate nanobioceramics with
magnesium: Effect of heat treatment on biological, physical and chemical properties
85120355525&doi=10.3390%2fceramics4040045&partnerID=40&md5=758ebecfb6e9f368ea370e6b
23ff35c3
VL - 4
ID - 14993
ER -
TY - JOUR
AB - A novel drug delivery system for the treatment of periodontitis was developed
using two components. The first was tetracycline base loaded into the microtubular
excipient halloysite, which was coated with chitosan to further retard drug
release. Encapsulation efficiencies of 32.5% were achieved with the loading
procedure, with tetracycline base showing in vitro release for up to 50 days in
simulated gingival crevicular fluid. The second component developed was a vehicle
for the drug loaded coated halloysite, which was primarily based on the
thermoresponsive polymer, poloxamer 407. A concentration of 20% was chosen with the
thermoresponsivity of the system modified using PEG 20,000 so that the mobile
product at room temperature would gel by temperature rise following syringing into
a periodontal pocket. Retention of the overall system in the pocket was further
improved by the addition of octyl cyanoacrylate (OCA). The thermoresponsivity of
the poloxamer 407 system proved to be sensitive to the presence of added excipients
with the levels of PEG 20,000 and OCA requiring modification in the presence of the
halloysite component. A final formulation was developed which consisted of 200mg of
halloysite double loaded with tetracycline base and coated with chitosan, suspended
in 1ml of poloxamer 407 20% (w/w), PEG 20,000 0.5% (w/w), OCA 1.0% (w/w), water to
100%, adjusted to pH 4. The syringeability of this formulation at various
temperatures was evaluated to ensure ease of delivery to the periodontal pocket. A
stability study was performed to examine the change in thermoresponsivity over
time, with the final formulation found to be stable for at least 9 months when
stored at room temperature (∼20°C). This formulation offered ease of delivery to
the periodontal pocket and sustained release of the antibiotic for up to 6 weeks.
The formulation had preliminary in vivo testing performed in dogs to determine
levels of drug release, antimicrobial activity and retentive ability of the
product. A wound pocket creation model was developed for the purposes of the trial.
The product was easy to deliver to the pockets with application times of less than
1min. Results showed the product was retained in the pocket for up to 6 weeks with
effective tetracycline levels released locally over this time period, which
achieved good antibacterial activity. © 2004 Elsevier B.V. All rights reserved.
AN - rayyan-563560865
AU - Kelly, H. M.
AU - Deasy, P. B.
AU - Ziaka, E.
AU - Claffey, N.
DO - 10.1016/j.ijpharm.2004.01.019
IS - 1
KW - chitosan
cyanoacrylic acid octyl ester
excipient
polymer
tetracycline
animal experiment
animal model
article
controlled study
drug formulation
drug release
drug screening
encapsulation
gingivitis
male
nonhuman
periodontitis
priority journal
room temperature
LA - English
PY - 2004
SN - 0378-5173
SP - 167-183
ST - Formulation and preliminary in vivo dog studies of a novel drug delivery
system for the treatment of periodontitis
T2 - Int. J. Pharm.
TI - Formulation and preliminary in vivo dog studies of a novel drug delivery
system for the treatment of periodontitis
VL - 274
ID - 14239
ER -
TY - JOUR
AB - The aim of this study was to test the effect of chlorhexidine gel application
on periodontal health of abutment teeth in patients with overdentures. 19 patients
with immediate overdentures were distributed at random among 2 experimental groups.
In these groups, a placebo and chlohexidine gel were daily applied. Patients were
recalled at 6-month intervals over a period of 2 years. In both groups, pocket
depth, tooth mobility and bleeding index were initially found to decrease after
insertion of the overdenture. In the chlorhexidine group, the bleeding index
remained very low over the 2-year period. Whereas in the placebo group, the
bleeding index gradually returned to the baseline values. The pocket depth in the
chlorhexidine group remained below the baseline value, in contrast to values in the
control group. The width of the attached gingiva decreased in both the groups, but
less in the chlorhexidine group.
AN - rayyan-563561163
AU - Keltjens, H. M.
AU - Schaeken, M. J.
AU - van der Hoeven, J. S.
AU - Hendriks, J. C.
IS - 2
KW - chlorhexidine
adult
aged
article
clinical trial
denture
gel
human
middle aged
mouth hygiene
periodontal disease
periodontics
LA - English
PY - 1991
SN - 0905-7161
SP - 71-74
ST - Effects of chlorhexidine gel on periodontal health of abutment teeth in
patients with overdentures
T2 - Clin Oral Implants Res
TI - Effects of chlorhexidine gel on periodontal health of abutment teeth in
patients with overdentures
VL - 2
ID - 14537
ER -
TY - JOUR
AB - In the area of parenteral controlled release formulations, in situ forming
implants (ISFI) are attractive alternatives to preformed implants and
microparticles. ISFI avoid the use of large needles or microsurgery and they can be
manufactured in simple steps with a low requirement of equipment and processes.
They are injected as low viscous solutions and transform in the body to a gel or
solid depot. Different triggers can be used to stimulate this transformation: (1)
in situ cross-linking, (2) in situ solidifying organogels, and (3) in situ phase
separation. The review discusses the principles and the pros and cons of each
strategy. It also gives examples of clinically used products or systems which are
currently in clinical trials. Although the principle of ISFI is so attractive, key
issues remain to be solved. They include (i) variability of the implant shape and
structure, (ii) avoidance of burst release during implant formation, and (iii)
toxicity issues. Unfortunately, until now our knowledge concerning the detailed
processes of the implant formation is still very limited. This is due to the fact
that the processes of implant formation and degradation, drug release and tissue
response are complex, heterogeneous, interconnected and not easy to follow,
especially in vivo. Despite this statement, many efforts are made in industry and
academia to improve current approaches. New materials and approaches enter the
preclinical and clinical phases and one can be sure, that ISFI will gain further
clinical importance within the next years. © 2012 Elsevier B.V. All rights
reserved.
AN - rayyan-563560539
AU - Kempe, S.
AU - Mäder, K.
DO - 10.1016/j.jconrel.2012.04.016
IS - 2
KW - alginic acid
bupivacaine
chitosan
cyclosporine
doxorubicin
doxycycline hyclate
drug carrier
ethinylestradiol plus levonorgestrel
insulin
leuprorelin
paclitaxel
poloxamer
polymer
risperidone
rivastigmine
adult disease
advanced cancer
Alzheimer disease
bipolar disorder
cancer adjuvant therapy
chemical structure
cross linking
drug efficacy
esophagus cancer
hydrogel
in situ forming implant
nonhuman
periodontitis
pH
phase transition
polymerization
postoperative pain
priority journal
prostate cancer
review
schizophrenia
separation technique
synthesis
viscosity
atridox
eligard
oncogel
posidur
relday
taxol
LA - English
PY - 2012
SN - ["0168-3659", "1873-4995"]
SP - 668-679
ST - In situ forming implants - An attractive formulation principle for parenteral
depot formulations
TI - In situ forming implants - An attractive formulation principle for parenteral
depot formulations
VL - 161
ID - 13913
ER -
TY - JOUR
AB - Azithromycin (AZM) is a potential antimicrobial drug for periodontitis
treatment. However, a potential sustained-release system is needed for intra-
periodontal pocket delivery. This study focused on the development and evaluation
of a thermoresponsive azithromycin-loaded niosome gel (AZG) to search for a
desirable formulation for periodontitis treatment. AZG was further developed from
an AZM-loaded niosomal formulation by exploiting the advantages of poloxamer 407
(P407) and hyaluronic acid (HA) interactions. The results showed that the addition
of HA decreased the gelation temperature and gelation time of AZG. HA was found to
increase the viscosity as well as mucoadhesive and tooth-root surface adhesive
properties. The AZG solution state was injectable and exhibited pseudoplastic
shear-thinning behavior. P407–HA interactions in AZG could contribute to gel
strength. AZG showed 72 h of continuous drug release following the Korsmeyer–Peppas
model and potentially enhanced drug permeation. The formulations apparently
presented more efficient antibacterial activity against major periodontal pathogens
than the standard AZM solution. AZM intra-periodontal pocket formulation and the
remarkable properties of niosomes exhibited potential characteristics, including
ease of administration, bioadhesion to the anatomical structure of the periodontal
pocket, and sustained drug release with competent antimicrobial activity, which
could be beneficial for periodontitis treatment.
AN - rayyan-563559801
AU - Kerdmanee, K.
AU - Phaechamud, T.
AU - Limsitthichaikoon, S.
IS - 10
azithromycin
hyaluronic acid
niosome
plastic
poloxamer
adhesion
article
chemical analysis
controlled study
drug development
drug screening
ex vivo study
flow kinetics
gelation
human
human tissue
in vitro study
infectious agent
injectability
periodontal pocket
periodontitis
physical chemistry
reaction temperature
shear thinning
texture analysis
time
tooth root
viscosity
LA - English
PY - 2022
SN - 1999-4923
ST - Thermoresponsive Azithromycin-Loaded Niosome Gel Based on Poloxamer 407 and
Hyaluronic Interactions for Periodontitis Treatment
T2 - Pharmaceutics
TI - Thermoresponsive Azithromycin-Loaded Niosome Gel Based on Poloxamer 407 and
Hyaluronic Interactions for Periodontitis Treatment
VL - 14
ID - 13175
ER -
TY - JOUR
AB - Background: The present study was intended to comparatively assess the
efficacy of ganglioside polymeric nanoparticle-coated 0.25% satranidazole-loaded
nanoparticles in gel form with that of the commercially available 1% metronidazole
gel as a local drug delivery (LDD) agent for the treatment of periodontal pockets.
Materials and Methods: A split-mouth randomized clinical trial was carried out in
46 chronic periodontitis patients with probing pocket depth (PPD) ≥4 mm or clinical
attachment loss greater than 3 mm on both quadrants of the same arch. Full-mouth
scaling and root planing (SRP) was performed for all the patients followed by
application of 0.25% satranidazole-loaded nanoparticles in gel form on one site
(Group 1) and commercially available 1% metronidazole gel on another site (Group
2). Clinical parameters (gingival index, plaque index, PPD, clinical attachment
level gain, and bleeding on probing) and microbiological analysis of the
subgingival plaque samples were performed and assessed at baseline, after SRP, 21
st day, and 90 th day post treatment. Unpaired 't'-test and ANOVA tests were used
for intergroup and intragroup comparison of recorded parameters. Results: The
results showed that the satranidazole-loaded nanoparticle group as an adjunct to
SRP in chronic periodontitis showed a statistically significant improvement in all
the clinical parameters and a fewer relapse of microbial flora in comparison with
the metronidazole group as an LDD agent. Conclusion: The present study depicted
that both the LDD agents showed an effective improvement of clinical as well as
microbiological parameters, but the satranidazole group consistently produced
better results than the metronidazole group and hence has a promising future as an
LDD agent in treating periodontal pockets.
AN - rayyan-563559828
AU - Kesarwani, S.
AU - Parihar, S.
AU - Singh, S.
AU - Gautam, A.
AU - Pandey, A.
AU - Anjum, M.
DO - 10.4103/jisp.jisp_233_21
IS - 4
KW - Delsa Nano C
disposable equipment
particle size analyzer
periodontal probe
sonicator
syringe
syringe needle
UNC 15
ganglioside
gel
metronidazole
nanocarrier
satranidazole
adjuvant therapy
article
Bacteroides
bleeding on probing
clinical article
coating (procedure)
controlled study
dental scaling
drug efficacy
Fusobacterium
gingiva
gingival index
human
mouth flora
nonhuman
periodontal pocket
pilot study
plaque index
Porphyromonas
Prevotella
relapse
root planing
tooth plaque
LA - English
PY - 2022
SN - ["0975-1580", "0972-124X"]
SP - 378-383
ST - A new era of Nano!!! Comparative evaluation of ganglioside polymeric
nanoparticle coated satranidazole gel and 1% metronidazole gel for the treatment of
periodontitis
TI - A new era of Nano!!! Comparative evaluation of ganglioside polymeric
nanoparticle coated satranidazole gel and 1% metronidazole gel for the treatment of
periodontitis
VL - 26
ID - 13202
ER -
TY - CONF
AN - rayyan-563561673
AU - Khaing, E. M.
AU - Intaraphairot, T.
AU - Chuenbarn, T.
AU - Chantadee, T.
AU - Phaechamud, T.
DA - 2021
DO - 10.1016/j.matpr.2021.03.622
SP - 3585-3593
ST - Natural resin-based solvent exchange induced in-situ forming gel for
vancomycin HCl delivery to periodontal pocket
T2 - Materials Today: Proceedings
TI - Natural resin-based solvent exchange induced in-situ forming gel for
85117232596&doi=10.1016%2fj.matpr.2021.03.622&partnerID=40&md5=5e007dc87c3a01a5dc41
4a2e2185a54d
VL - 47
ID - 15047
ER -
TY - CPAPER
AB - Natural resins such as benzoin, propolis and rosin have been widely employed
in the pharmaceuticals. In this study, in situ forming gels (ISG) were prepared
using natural resins as matrix forming agents to deliver vancomycin hydrochloride
(VH) for periodontitis treatment. The formulations were investigated for their
physicochemical properties, drug release and antimicrobial activities.
Transformation from a solution to a solid matrix was achieved after the formulas
were exposed to a simulated crevicular fluid. The rate of resin matrix formation
was found to decrease with time and became more opaque owing to gradual phase
separation with resin network formation. They flowed with pseudo-plastic behavior
and provided appropriate injectability as well as good mechanical properties.
Sustained VH release was attained for a 5-day period. VH-loaded natural resin ISGs
inhibited against Staphylococcus aureus, Porphyromonas gingivalis, Candida
albicans, and Streptococcus mutans. Natural resin-based ISGs comprising of propolis
or benzoin showed a more effective delivery of VH than that of rosin. Thus, VH-
loaded benzoin and propolis ISGs were found to have a possible application for
infected periodontitis treatment. (c) 2021 Elsevier Ltd. All rights reserved.
Selection and peer-review under responsibility of the scientific committee of the
5th International Conference on Smart Materials and Nanotechnology.
AN - rayyan-563562250
AU - Khaing, E. M.
AU - Intaraphairot, T.
AU - Chuenbarn, T.
AU - Chantadee, T.
AU - Phaechamud, T.
DO - 10.1016/j.matpr.2021.03.622
PY - 2021
SP - 3585-3593
TI - Natural resin-based solvent exchange induced in-situ forming gel for
VL - 47
ID - 15624
ER -
TY - JOUR
AB - Localized intra-periodontal pocket drug delivery using an injectable in situ
forming gel is an effective periodontitis treatment. The aqueous insoluble property
of rosin is suitable for preparing a solvent exchange-induced in situ forming gel.
This study aims to investigate the role of incorporating lime peel oil (LO) on the
physicochemical properties of injectable in situ forming gels based on rosin loaded
with 5% w/w doxycycline hyclate (DH) in dimethyl sulfoxide (DMSO) and N-methyl
pyrrolidone (NMP). Their gel formation, viscosity, injectability, mechanical
properties, wettability, drug release, and antimicrobial activities were evaluated.
The presence of LO slowed gel formation due to the loose precipitate formation of
gel with a high LO content. The viscosity and injectability were slightly increased
with higher LO content for the DH-loaded rosin-based in situ forming gel. The
addition of 10% LO lowered gel hardness with higher adhesion. LO incorporation
promoted a higher drug release pattern than the no oil-added formulation over 10
days and the gel formation rate related to burst drug release. The drug release
kinetics followed the non-Fickian diffusion mechanism for oil-added formulations.
LO exhibited high antimicrobial activity against Porphyromonas gingivalis and
Staphylococcus aureus. The DH-loaded rosin in situ forming gel with an addition of
LO (0, 2.5, 5, and 10% w/w) inhibited all tested microorganisms. Adding 10% LO to
rosin-based in situ forming gel improved the antimicrobial activities, especially
for the P. gingivalis and S. aureus. As a result, the study demonstrates the
possibility of using an LO amount of less than 10% loading into a rosin-based in
situ forming gel for efficient periodontitis treatment.
AN - rayyan-563560943
AU - Khaing, E. M.
AU - Mahadlek, J.
AU - Okonogi, S.
AU - Phaechamud, T.
DO - 10.3390/gels8030169
IS - 3
J2 - Gels
LA - eng
N1 - Programme of Pharmaceutical Engineering, Faculty of Pharmacy, Silpakorn
University, Nakhon Pathom 73000, Thailand.; Pharmaceutical Intelligence Unit
Prachote Plengwittaya, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom
73000, Thailand.; Natural Bioactive and Material for Health Promotion and Drug
Delivery System Group (NBM), Faculty of Pharmacy, Silpakorn University, Nakhon
Pathom 73000, Thailand.; Research Center of Pharmaceutical Nanotechnology, Faculty
of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.; Department of
Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai
50200, Thailand.; Programme of Pharmaceutical Engineering, Faculty of Pharmacy,
Silpakorn University, Nakhon Pathom 73000, Thailand.; Natural Bioactive and
Material for Health Promotion and Drug Delivery System Group (NBM), Faculty of
Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.; Department of
Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom
73000, Thailand.
PY - 2022
ST - Lime Peel Oil-Incorporated Rosin-Based Antimicrobial In Situ Forming Gel
TI - Lime Peel Oil-Incorporated Rosin-Based Antimicrobial In Situ Forming Gel
VL - 8
Y2 - 3 y3 - 8
ID - 14317
ER -
TY - JOUR
AN - rayyan-563561586
AU - Khaing, E. M.
AU - Mahadlek, J.
AU - Okonogi, S.
AU - Phaechamud, T.
DO - 10.3390/gels8030169
IS - 3
PY - 2022
ST - Lime Peel Oil–Incorporated Rosin-Based Antimicrobial In Situ Forming Gel
T2 - Gels
TI - Lime Peel Oil–Incorporated Rosin-Based Antimicrobial In Situ Forming Gel
85126689914&doi=10.3390%2fgels8030169&partnerID=40&md5=97cd16df5f1f0df8d03b9aa63be5
2f7e
VL - 8
ID - 14960
ER -
TY - JOUR
AB - Background/Objectives: Papillon-Lefevre syndrome (PLS) is an autosomal
recessive disorder caused by Cathepsin C gene mutation. Patients suffer from
palmoplantar keratosis, periodontitis, and early loss of teeth. Few periodontists
have attempted to preserve natural dentition and avoid total clearance of both
primary and permanent teeth which causes severe psychological trauma, indigestion
problems and sabotages future attempts for prosthetic intervention. As a
continuation of a previous study, this study aims to assess the best intervention
to preserve natural dentition and delay bone loss in patients with PLS. Methods: 5
patients aged 8 to 14 years diagnosed with PLS by molecular and biochemical
analysis. All patients received 1 year treatment divided into 2 successive phases
as in the following table Periodontal condition was assessed clinically and by cone
beam x-ray at the beginning and the end of each phase. Results: Gingival indices
showed marked stability during both phases. No teeth were lost or showed increased
mobility. Bone level and density were more stable only during the second phase.
Conclusion: Oral hygiene measures aided by diode laser can stabilize the clinical
dental condition in PLS patients. Adding chlorohexidine gel was more effective in
controlling bone loss.
AN - rayyan-563559721
AU - Khalil, Y.
AU - Ahmed, N.
AU - Abdelmassih, P. M.
AU - Mustafa, H.
AU - Abderazik, M.
DO - 10.1038/s41431-023-01338-4
KW - chlorhexidine
adolescent
bone level
child
clinical article
clinical assessment
conference abstract
controlled study
dentition
diode laser
drug therapy
female
gingival index
human
male
mouth hygiene
osteolysis
Papillon Lefevre syndrome
periodontium
plant cone
X ray
LA - English
PY - 2023
SN - 1476-5438
SP - 664
ST - Periodontal management for patients suffering from Papillon-Lefevre syndrome
T2 - Eur. J. Hum. Genet.
TI - Periodontal management for patients suffering from Papillon-Lefevre syndrome
VL - 31
ID - 13095
ER -
TY - JOUR
AB - Polymeric systems made of poly(lactic acid) or poly(lactic-co-glycolic acid)
are widely used for long-Term delivery of small and large molecules. The advantages
of poly(lactic acid)/poly(lactic-co-glycolic acid) systems include
biodegradability, safety and a long history of use in US FDA-Approved products.
However, as drugs delivered by the polymeric systems and their applications become
more diverse, the significance of microenvironment change of degrading systems on
long-Term drug stability and release kinetics has gained renewed attention. In this
review, we discuss various issues experienced with acidifying microenvironment of
biodegradable polymer systems and approaches to overcome the detrimental effects of
polymer degradation on drug stability and release control.
AN - rayyan-563560060
AU - Khaliq, N. U.
AU - Chobisa, D.
AU - Richard, C. A.
AU - Swinney, M. R.
AU - Yeo, Y.
DO - 10.4155/tde-2020-0113
IS - 1
KW - NCT01180062
NCT01681381
NCT01729195
NCT02221453
NCT02487186
NCT02726646
NCT02982889
NCT03401216
NCT04082962
NCT04094298
bone screw
drug eluting stent
drug implant
intravitreal implant
ophthalmic drug insert
angiopeptin
bupivacaine
buprenorphine
chitosan
ciprofloxacin
cyclodextrin
dexamethasone
dextran
doxycycline
doxycycline hyclate
everolimus
exendin 4
gel
goserelin
insulin
latanoprost
leuprorelin
leuprorelin plus norethisterone acetate
lysozyme
macrogol
microsphere
minocycline
mometasone furoate
naltrexone
octreotide
pasireotide
poloxamer
polycaprolactone
polydioxanone
polyester
polyglactin
polylactic acid
polylactide
polymer
polyvinyl alcohol
povidone
progesterone
propel
sirolimus
recombinant basic fibroblast growth factor
resomer
risperidone
shellac
sucrose
tetanus toxoid
tetracycline
trehalose
triamcinolone
triptorelin
acidification
acromegaly
advanced cancer
alcoholism
ankle fracture
biodegradability
biodegradation
bipolar I disorder
breast cancer
chronic sinusitis
confocal microscopy
diabetic macular edema
diarrhea
drug formulation
drug release
drug stability
endometriosis
foreign body reaction
gastroenteropancreatic neuroendocrine tumor
glaucoma
growth hormone deficiency
human
inflammation
long term care
macular edema
nonhuman
opiate addiction
osteoarthritis
pain
periodontal disease
periodontitis
porosity
precocious puberty
priority journal
prostate cancer
retina detachment
retina disease
review
rotator cuff injury
schizophrenia
single drug dose
suspension
uvea melanoma
uveitis
viscosity
voltammetry
arestin
atridox
bydureon
bydureon bcise
eligard
lupaneta pack
lupron depot
nutropin depot
ozurdex
perseris
risperdal consta
sandostatin lar
signifor
somatuline depot
sublocade
trelstar
triptodur kit
vivitrol
zilretta
zoladex
LA - English
PY - 2021
SN - ["2041-6008", "2041-5990"]
SP - 37-54
ST - Engineering microenvironment of biodegradable polyester systems for drug
stability and release control
T2 - Ther. Deliv.
TI - Engineering microenvironment of biodegradable polyester systems for drug
stability and release control
VL - 12
ID - 13434
ER -
TY - JOUR
AN - rayyan-563561838
AU - Khan, G.
AU - Patel, R. R.
AU - Yadav, S. K.
AU - Kumar, N.
AU - Chaurasia, S.
AU - Ajmal, G.
AU - Mishra, P. K.
AU - Mishra, B.
DO - 10.1039/c6ra22072j
IS - 102
PY - 2016
SP - 100214-100229
ST - Development, optimization and evaluation of tinidazole functionalized
electrospun poly(ϵ-caprolactone) nanofiber membranes for the treatment of
periodontitis
T2 - RSC Advances
TI - Development, optimization and evaluation of tinidazole functionalized
electrospun poly(ϵ-caprolactone) nanofiber membranes for the treatment of
periodontitis
84993978540&doi=10.1039%2fc6ra22072j&partnerID=40&md5=4b4bc0a718ec6b46cdb29794e1f62
ead
VL - 6
ID - 15212
ER -
TY - JOUR
AB - The aim of this study was to alleviate shortcomings in the treatment of
periodontitis by electrospinning of a novel biodegradable poly(epsilon-
caprolactone) (PCL) based nanofiber membrane functionalized with tinidazole (TNZ).
Box-Behnken design was employed for evaluating influence of formulation and
processing variables on entrapment efficiency (EE) and diameter of nanofiber. The
optimum batch selected by desirability approach was subjected to physicochemical
characterization such as FTIR, DSC and PXRD which revealed entrapment of drug in a
molecular dispersion devoid of any chemical interaction with the excipients.
Electron microscopy showed smooth structure in nanometre range, without any visible
sign of fiber break-up or disruption within the nanofiber membrane. Optimized TNZ-
PCL nanofiber membrane exhibited a diameter of 147.6 +/- 7.6 nm and EE 84.36 +/-
1.5%. In vitro release study and antibacterial study demonstrated sustained drug
release for up to 20 days, depending upon the drug to polymer ratio and solvent
composition. Further, reduction of contact angle (from 123.6 +/- 2.8 to 57.2 +/-
1.9) revealed that incorporation of TNZ enhanced the hydrophilicity of the
nanofiber membrane which would facilitate its adhesion to the site of action and
instigate proliferation of cells. MTT assay and CLSM study suggested that nanofiber
membrane showed no cytotoxicity on mouse fibroblasts (L-929 cell lines). Moreover,
in vivo study by ligature-induced periodontitis in rats confirmed that TNZ loaded
nanofiber membrane can significantly (p < 0.05) improve continuity of epithelium
and transseptal fiber of interdental papilla in comparison to tinidazole gel.
AN - rayyan-563562489
AU - Khan, G.
AU - Patel, R. R.
AU - Yadav, S. K.
AU - Kumar, N.
AU - Chaurasia, S.
AU - Ajmal, G.
AU - Mishra, P. K.
AU - Mishra, B.
DO - 10.1039/c6ra22072j
IS - 102
PY - 2016
SN - 2046-2069
SP - 100214-100229
ST - Development, optimization and evaluation of tinidazole functionalized
electrospun poly-(epsilon-caprolactone) nanofiber membranes for the treatment of
periodontitis
T2 - RSC ADVANCES
TI - Development, optimization and evaluation of tinidazole functionalized
electrospun poly-(epsilon-caprolactone) nanofiber membranes for the treatment of
periodontitis
VL - 6
ID - 15863
ER -
TY - JOUR
AB - Periodontal diseases are inflammations of the periodontium caused by certain
microorganisms, leading to progressive destruction of the periodontal ligament and
alveolar bone. Conventional medications have limitations such as extrinsic tooth
discoloration, altered taste sensation, and the development of bacterial
resistance. Licorice is an herb with glycyrrhetinic acid (GA) as its main active
component. GA has antimicrobial, anti-inflammatory and antioxidant activity. There
is limited evidence for the preparation and in vitro evaluation of licorice extract
as a topical drug in periodontology. The aim of this study was the formulation and
in vitro characterization of a controlled-release gel containing licorice extract
that can be used as a topical agent in periodontal therapy. An in vitro study was
conducted in which an ethanolic extract of licorice was prepared. The local drug
delivery gel was formulated with the specified minimum inhibitory concentration of
Glycyrrhiza glabra using Carbopol 940 polymer. In vitro characterization of the
formulated gel was done in terms of physical appearance, determination of pH,
squirtability, drug content, gelation temperature and time, viscosity, mucoadhesive
force, in vitro drug release, thermodynamic stability and X-ray diffraction
analysis. The licorice gel formulation was thermodynamically stable, mucoadhesive,
and sprayable. It also released the drug slowly for up to 48 hours. The
incorporation of licorice extract into a polymeric gel base exhibits good
physicochemical properties, adequate mucoadhesiveness, and controlled drug release.
Thus, it is a potential herbal extract for local drug delivery that can be used to
improve the therapeutic results of scaling and root planning.
AN - rayyan-563559916
AU - Khan, S. F.
AU - Shetty, B.
AU - Khan, A. M.
AU - Fazal, I.
DO - 10.29228/jrp.202
IS - 4
KW - carbopol 940
gel
glycyrrhetinic acid
herbaceous agent
polymer
article
controlled study
drug formulation
force
gelation
Glycyrrhiza glabra
in vitro study
mucoadhesion
nonhuman
periodontal disease
pH
physical appearance
physical chemistry
temperature
thermodynamics
time
viscosity
X ray diffraction
LA - English
PY - 2022
SN - 2630-6344
SP - 1037-1051
ST - Formulation and in-vitro characterization of herbal licorice gel for
periodontal therapy
T2 - J. Res. Pham.
TI - Formulation and in-vitro characterization of herbal licorice gel for
periodontal therapy
VL - 26
ID - 13290
ER -
TY - JOUR
AN - rayyan-563560141
AU - Khan, S.
AU - Rahman, S. Z.
DO - 10.3329/bjms.v19i2.44993
IS - 2
KW - aspartame
carbomer
folic acid
gel
glycerol
macrogol 200
methyl paraben
mouthwash
propyl paraben
angiogenesis
B12 deficiency
desquamation
drug formulation
editorial
epithelization
gene expression
gingivitis
human
mouth ulcer
nonhuman
upregulation
wound healing
LA - English
PY - 2020
SN - ["2076-0299", "2223-4721"]
SP - 187-188
ST - A novel formulation of folic acid gel in the treatment of desquamative
gingivitis
T2 - Bangladesh J. Med. Sci.
TI - A novel formulation of folic acid gel in the treatment of desquamative
gingivitis
VL - 19
ID - 13515
ER -
TY - JOUR
AB - The clinical efficacy of topical administration of standardised fermented
papaya gel (SFPG), known to have antioxidant and anti-inflammatory properties,
versus conventional therapy was evaluated in a group of 84 patients with moderate-
to-severe periodontitis, randomly assigned to control group (n = 45) undergoing
traditional pharmacologic/surgical protocols or to experimental group (n = 39),
additionally treated with intragingival pocket SFPG (7 g) applications (15 min
daily for 10 days). Patients undergoing SFPG treatment showed significant (P <
0.05), durable improvement of three major clinical indices of disease severity:
reduced bleeding (day 7), plaque and gingival conditions (day 14), and consistent
gingival pocket depth reduction (day 45). Proinflammatory nitric oxide metabolites
reached normal values in plasma (day 14) and gingival crevicular fluid (GCF) at day
45 with SFPG applications compared to controls that did not reach normalisation.
Levels of highly increased proinflammatory (IL-1B, IL-6) and suppressed anti-
inflammatory (IL-10) cytokines normalised in the SFPG group by days 14 (plasma) and
45 (GCF), but never in the control group. Although not acting directly as
antibiotic, SFPG acted in synergy with human granulocytes blocking adaptive
catalase induction in S. aureus in response to granulocyte-derived oxidative
stress, thus enhancing intracellular bacterial killing.
AN - rayyan-563560361
AU - Kharaeva, Z. F.
AU - Zhanimova, L. R.
AU - Mustafaev, M. S.
AU - De Luca, C.
AU - Mayer, W.
AU - Chung Sheun Thai, J.
AU - Tiew Siok Tuan, R.
AU - Korkina, L. G.
DO - 10.1155/2016/9379840
antioxidant
catalase
herbaceous agent
interleukin 10
interleukin 1beta
interleukin 6
nitric oxide
standardised fermented papaya gel
superoxide
unclassified drug
adult
article
bacterial strain
bacterial survival
Carica
chemoluminescence
controlled study
disease severity
enzyme activity
enzyme induction
female
gingiva
gingivitis
granulocyte
human
human cell
intracellular killing
male
metabolite
oral bleeding
oxidative stress
phagocytosis
priority journal
tooth plaque
treatment response
LA - English
PY - 2016
SN - ["1466-1861", "0962-9351"]
ST - Effects of Standardised Fermented Papaya Gel on Clinical Symptoms,
Inflammatory Cytokines, and Nitric Oxide Metabolites in Patients with Chronic
Periodontitis: An Open Randomised Clinical Study
T2 - Mediators Inflamm.
TI - Effects of Standardised Fermented Papaya Gel on Clinical Symptoms,
Inflammatory Cytokines, and Nitric Oxide Metabolites in Patients with Chronic
Periodontitis: An Open Randomised Clinical Study
VL - 2016
ID - 13735
ER -
TY - JOUR
AB - Objective. The aim of this clinical study was to evaluate the effectiveness
of a whitening toothpaste containing 3% carbamide peroxide and lactoperoxidase.
Materials and methods. Participants were instructed to brush their teeth using an
enzymatic-activated dentifrice following a particular procedure for three weeks.
Color was recorded before and after treatment using a VITA Easyshade
spectrophotometer. Differences in L∗ (tooth color lightness), a∗ (displacement
along the red-green axis), and b∗ (displacement along the yellow-blue axis) were
measured before and after treatment using the paired t and the Wilcoxon signed-rank
tests. Color changes (ΔE) were calculated using the obtained measurements. Results.
Thirty-four volunteers were included. ΔE was 4.03. For the set of 348 teeth, a
greater tendency towards green (lower a∗) and blue (lower b∗) was observed (p <
0.05). There were no significant differences in lightness after treatment.
Mandibular central incisors showed a greater tendency towards green (lower a∗) and
blue (lower b∗). Bleaching effectiveness was observed in both the upper and lower
central incisors and in the lateral mandibular incisors. Conclusion. Based on these
results, it may be concluded that brushing with an enzymatic-activated dentifrice
is effective for whitening teeth.
AN - rayyan-563560040
AU - Khemiss, M.
AU - Kallel, I.
AU - Zouaghi, H.
AU - Ben Khelifa, M.
AU - Bagga, S.
DO - 10.1155/2021/7143623
spectrophotometer
toothbrush
carbamide peroxide
gel
lactoperoxidase
peroxide
sodium fluoride
toothpaste
xylitol
adult
article
clinical article
clinical assessment
clinical evaluation
color
controlled study
dental procedure
enzyme activity
female
gingival index
human
incisor
inflammation
male
mandibular central incisor
side effect
social status
soft tissue
tooth brushing
tooth color
treatment duration
LA - English
PY - 2021
SN - ["1687-8736", "1687-8728"]
ST - Whitening Efficacy of 3% Carbamide Peroxide Gel Activated by Lactoperoxidase
T2 - Int. J. Dent.
TI - Whitening Efficacy of 3% Carbamide Peroxide Gel Activated by Lactoperoxidase
VL - 2021
ID - 13414
ER -
TY - JOUR
AB - Healing and regeneration of periodontium are considered as a complex
physiological process. Therefore, treatments need to be addressed with highly
effective components modulating the multiple pathways. In this study,
exopolysaccharide (EPS) produced by Weissella cibaria EIR/P2, was partially
purified from the culture supernatant and subjected to characterization within the
aim of evaluating its potential for periodontal regeneration. High-Performance
Liquid Chromatography analysis revealed a single-peak corresponding to the glucose
which identified the EPS as dextran. Fourier transform-infrared spectra were also
displayed characteristic peaks for polysaccharides. According to the results of gel
permeation/size exclusion-chromatography, the molecular mass was determined to be 8
× 106 Da. To clarify its anti-bacterial activity on Streptococcus mutans, effects
on viability and biofilm formation was evaluated. At 50 mg/mL, dextran exhibited a
bactericidal effect with 70% inhibition on biofilm formation. Besides, dose-
dependent antioxidant effects were also detected. The efficacy of dextran in
enhancing the viability of human periodontal ligament fibroblast cells (hPDLFCs)
was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium-bromide (MTT)
assay, and an increase was observed in the viability of hPDLFCs. In conclusion,
dextran derived from W. cibaria can be potentially used as a multi-functional
bioactive polymer in the design of new therapeutic strategies to promote healing
and regeneration of periodontium.
AN - rayyan-563560064
AU - Kibar, H.
AU - Arslan, Y. E.
AU - Ceylan, A.
AU - Karaca, B.
AU - Haliscelik, O.
AU - Kiran, F.
DO - 10.1016/j.ijbiomac.2020.10.106
KW - analytical equipment
IRAffinity 1
Prominence 20A Series
biomaterial
dextran
exopolysaccharide
polysaccharide
amplicon
article
bacterial cell
bacterial strain
biofilm
cell viability
controlled study
dose response
fibroblast cell line
human
human cell
human tissue
MTT assay
nonhuman
periodontium
sequence analysis
tissue regeneration
Weissella cibaria
LA - English
PY - 2020
SN - ["1879-0003", "0141-8130"]
SP - 2900-2908
ST - Weissella cibaria EIR/P2-derived exopolysaccharide: A novel alternative to
conventional biomaterials targeting periodontal regeneration
TI - Weissella cibaria EIR/P2-derived exopolysaccharide: A novel alternative to
conventional biomaterials targeting periodontal regeneration
VL - 165
ID - 13438
ER -
TY - JOUR
AN - rayyan-563561984
AU - Kido, J. I.
AU - Kido, R.
AU - Kataoka, M.
AU - Fagerhol, M. K.
AU - Nagata, T.
DO - 10.1034/j.1600-0765.2003.00691.x
IS - 6
PY - 2003
SP - 557-563
ST - Calprotectin release from human neutrophils is induced by Porphyromonas
gingivalis lipopolysaccharide via the CD-14-Toll-like receptor-nuclear factor κB
pathway
TI - Calprotectin release from human neutrophils is induced by Porphyromonas
pathway
0344304460&doi=10.1034%2fj.1600-
0765.2003.00691.x&partnerID=40&md5=a881544b93d0687d5450be31a6b2c01b
VL - 38
ID - 15358
ER -
TY - JOUR
AB - Objectives: Calprotectin is a cytosolic protein with antibacterial action in
leukocytes and its level increases in some inflammatory diseases, including
periodontal diseases, rheumatoid arthritis and ulcerative colitis. Recently, we
found that the lipopolysaccharide of Porphyromonas gingivalis (P-LPS) induced
calprotectin release from human neutrophils. P-LPS, a major virulence factor of
periodontal pathogens, is known to induce the production and release of
inflammatory cytokines through CD14, Toll-like receptor (TLR) and nuclear factor κB
(NF-κB). In the present study, we investigated whether calprotectin release by P-
LPS is induced via the CD14-TLR-NF-κB pathway and the cellular mechanism of
calprotectin release in human neutrophils. Material and methods: Human neutrophils
were isolated from the peripheral blood of healthy donors and pre-incubated in
medium containing antibodies against CD14, TLR2 and TLR4, or several inhibitors of
NF-κB, microtubules and microfilaments, and then incubated with P-LPS. The
calprotectin amount in the culture medium was determined using ELISA, and the
nuclear extracts from cells were used for the examination of NF-κB binding activity
using electrophoretic mobility shift assays. Results: P-LPS increased calprotectin
release from neutrophils and its induction was inhibited by anti-CD14 and anti-TLR2
antibodies, but not by two anti-TLR4 antibodies. NF-κB inhibitors suppressed P-LPS-
induced NF-κB binding activity and calprotectin release. The inhibitors of
microtubule and microfilament polymerization significantly decreased P-LPS-induced
calprotectin release. Conclusion: These results suggest that calprotectin release
is induced by P-LPS via the CD14-TLR2-NF-κB signal pathway in human neutrophils and
may be dependent on microtubule and microfilament systems.
AN - rayyan-563560873
AU - Kido, J. I.
AU - Kido, R.
AU - Suryono
AU - Kataoka, M.
AU - Fagerhol, M. K.
AU - Nagata, T.
DO - 10.1034/j.1600-0765.2003.00691.x
IS - 6
KW - acetylcysteine
benzyloxycarbonylleucylleucylleucinal
caffeic acid phenethyl ester
calgranulin
CD14 antigen
colchicine
cytochalasin B
demecolcine
I kappa B
monoclonal antibody
monoclonal antibody cd14
monoclonal antibody hta 1216
monoclonal antibody hta 125
monoclonal antibody toll like receptor 2
monoclonal antibody toll like receptor 4
nocodazole
pyrrolidine dithiocarbamate
sn 50
unclassified drug
adult
article
blood
cell nucleus
clinical article
controlled study
culture medium
female
human
human cell
male
microfilament
microtubule
neutrophil
pathogenesis
periodontal disease
protein binding
protein secretion
virulence
mg 132
LA - English
PY - 2003
SN - 0022-3484
SP - 557-563
ST - Calprotectin release from human neutrophils is induced by Porphyromonas
pathway
TI - Calprotectin release from human neutrophils is induced by Porphyromonas
pathway
VL - 38
ID - 14247
ER -
TY - JOUR
AB - Background and Objective: Gingival crevicular fluid is a bodily fluid
transuded from periodontal tissues into the gingival crevice and periodontal
pocket, and contains many species of components. Proteins in gingival crevicular
fluid have been studied as markers for periodontal diseases. Mass spectrometric
analysis is used for the analyses of proteins, lipids, saccharides and metals, and
expected as an approach for disease diagnosis. For better analysis of the protein
components in gingival crevicular fluid, we investigated proteins in gingival
crevicular fluid samples from the healthy gingival crevice and periodontal pocket
using mass spectrometry. Material and Methods: Gingival crevicular fluid samples
were collected from subjects who gave their informed consent and were periodontally
healthy or had diseased pockets. These samples were electrophoretically separated,
and each fraction on the gels was analysed by nano liquid chromatography coupled
with tandem mass spectrometry. Antimicrobial peptides detected in gingival
crevicular fluid were confirmed by western blotting. Results: One hundred and four
proteins were detected in gingival crevicular fluid samples from both healthy sites
and sites of periodontitis; 64 proteins were contained only in gingival crevicular
fluid from healthy sites and 63 proteins were observed only in gingival crevicular
fluid from periodontitis sites. These proteins were blood-, cytoskeleton-,
immunity-, inflammation- and lipid-related proteins and enzymes. Some proteins,
including ceruloplasmin, glycogen phosphorylase, glutathione S-transferase,
phosphoglycerate mutase, psoriasin, S100A11 and resistin, were identified for the
first time in gingival crevicular fluid. Antimicrobial peptides, such as
lactoferrin, α1-antitrypsin, lipocalin, S100A7, S100A8, S100A9 and cathelicidin,
were observed by mass spectrometry and western blotting. Conclusion: Multiple
protein components in gingival crevicular fluid were analysed at the same time
using mass spectrometry, and this approach may be useful for the diagnosis of
periodontal diseases. © 2012 John Wiley & Sons A/S.
AN - rayyan-563560535
AU - Kido, J.
AU - Bando, M.
AU - Hiroshima, Y.
AU - Iwasaka, H.
AU - Yamada, K.
AU - Ohgami, N.
AU - Nambu, T.
AU - Kataoka, M.
AU - Yamamoto, T.
AU - Shinohara, Y.
AU - Sagawa, I.
AU - Nagata, T.
DO - 10.1111/j.1600-0765.2011.01458.x
IS - 4
KW - antimicrobial cationic peptide
ceruloplasmin
glycogen phosphorylase
phosphoglycerate mutase
protein
protein S 100
resistin
S100A1 protein
S100A7 protein, human
adult
aged
article
case control study
chemistry
enzymology
female
gingivitis
human
male
metabolism
methodology
middle aged
periodontal pocket
periodontitis
Western blotting
LA - English
PY - 2012
SN - ["0022-3484", "1600-0765"]
SP - 488-499
ST - Analysis of proteins in human gingival crevicular fluid by mass spectrometry
TI - Analysis of proteins in human gingival crevicular fluid by mass spectrometry
VL - 47
ID - 13909
ER -
TY - JOUR
AB - Calprotectin is a calcium binding protein produced by leukocytes, macrophages
and epithelial cells, and its levels in several tissues increase during infections
and in many inflamed areas, suggesting that it may be an indicator of inflammatory
activity. Osteopontin is a prominent phosphorylated glycoprotein in bone matrix,
having calcium binding capacity. Recently, it has been reported that calprotectin
and osteopontin are present in urinary stones (pathological mineralized masses in
the body), and that these proteins may be involved in their formation. Dental
calculus formed by mineralization of dental plaque is an inflammatory factor which
may contribute to periodontal disease. It contains many organic components involved
in mineralization. We recently found osteopontin molecules in human dental calculus
and suggested that the components of its matrix may be similar to those of urinary
stones. In this study, we investigated the presence of calprotectin in human dental
calculus by immunohistochemical and immunoblotting analyses using a specific
antibody for calprotectin. After fixation and demineralization of dental calculi
adhered to tooth roots, sections embedded in paraffin were immunoreacted with the
antibody for calprotectin and positive immunostaining for calprotectin was
observed. Dental calculus proteins were then extracted with EDTA and separated by
electrophoresis on 15% polyacrylamide gels. By immunoblotting analysis, 3 or 4
bands were observed at 11, 14.5, 22-25, 28 or 36.5 kDa and these patterns
corresponded to those of calprotectin subunits. When non-immune rabbit serum was
used instead of calprotectin-specific antibody as a negative control, no
immunoreactivity was observed. These findings indicate that calprotectin is
associated not only with antibacterial action but also with calcium binding
capacity during dental calculus formation.
AN - rayyan-563561044
AU - Kido, J.
AU - Nishikawa, S.
AU - Ishida, H.
AU - Yamashita, K.
AU - Kitamura, S.
AU - Kohri, K.
AU - Nagata, T.
IS - 4
KW - calcium binding protein
calgranulin
nerve cell adhesion molecule
article
chemistry
histology
human
immunoblotting
immunology
metabolism
tooth calculus
LA - English
PY - 1997
SN - 0022-3484
SP - 355-361
ST - Identification of calprotectin, a calcium binding leukocyte protein, in human
dental calculus matrix
TI - Identification of calprotectin, a calcium binding leukocyte protein, in human
dental calculus matrix
VL - 32
ID - 14418
ER -
TY - JOUR
AN - rayyan-563561613
AU - Kielan-Grabowska, Z.
AU - Bącela, J.
AU - Zięty, A.
AU - Seremak, W.
AU - Gawlik-Maj, M.
AU - Kawala, B.
AU - Borak, B.
AU - Detyna, J.
AU - Sarul, M.
DO - 10.3390/sym13091734
IS - 9
PY - 2021
ST - Improvement of properties of stainless steel orthodontic archwire using
tio2:Ag coating
T2 - Symmetry
TI - Improvement of properties of stainless steel orthodontic archwire using
tio2:Ag coating
85115791818&doi=10.3390%2fsym13091734&partnerID=40&md5=39f1e265c751da517397aa9233fb
c12e
VL - 13
ID - 14987
ER -
TY - JOUR
AB - Orthodontic treatment carries the risk of major complications such as enamel
demineralization, tooth decay, gingivitis, and periodontal damage. A large number
of elements of fixed orthodontic appliance results in the creation of additional
plaque retention sites which increase the risk of biofilm creation. Modification of
the surface of orthodontic elements may prevent the formation of bacterial biofilm.
In this paper, surface modification of stainless steel orthodontic wires with TiO2:
Ag was carried out by the sol-gel thin film dip-coating method. To obtain the
anatase crystal structure, substrates were calcined for 2 h at 500 degrees C. The
properties of the obtained coatings were investigated using scanning electron
microscopy, X-ray diffraction, and electrochemical tests. Corrosion studies were
performed in a Ringer's solution, which simulated physiological solution. SEM and
XRD analyses of the coated surface confirmed the presence of Ag nanoparticles which
may have antimicrobial potential.
AN - rayyan-563562585
AU - Kielan-Grabowska, Z.
AU - Bacela, J.
AU - Ziety, A.
AU - Seremak, W.
AU - Gawlik-Maj, M.
AU - Kawala, B.
AU - Borak, B.
AU - Detyna, J.
AU - Sarul, M.
DO - 10.3390/sym13091734
IS - 9
PY - 2021
SN - 2073-8994
ST - Improvement of Properties of Stainless Steel Orthodontic Archwire Using
TiO2:Ag Coating
T2 - SYMMETRY-BASEL
TI - Improvement of Properties of Stainless Steel Orthodontic Archwire Using
TiO2:Ag Coating
VL - 13
Y2 - 9
ID - 15959
ER -
TY - JOUR
AB - Porphyromonas gingivalis, an obligately anaerobic bacterium, is implicated as
a major pathogen in the development and progression of chronic periodontitis.
Although expression of several virulence factors of the bacterium has been found to
be affected by environmental stress such as entrance into the stationary growth
phase and heat, there is relatively little information on the mechanisms that may
operate in the bacterium in response to environmental stress. In this study, a
novel protein (UstA) was investigated that was initially identified following two-
dimensional gel analysis. Expression of UstA was upregulated in stationary phase or
by exposure to atmospheric oxygen. N-terminal sequencing and database analysis with
the P. gingivalis genome sequence revealed that the UstA-encoding gene (ustA) was
located upstream of a homologue of the usp gene encoding the universal stress
protein on the chromosome. The ustA gene appeared to be transcribed in a
monocistronic fashion, as revealed by primer extension and Northern blot analysis.
To elucidate the role of UstA in the bacterium, chromosomal mutants carrying a
disruption of the ustA gene were constructed. The ustA mutant grew slower than the
wild-type parent strain in rich medium, resulting in a lower yield in stationary
phase. Furthermore, in this mutant, expression levels of the P. gingivalis
homologues of superoxide dismutase, thiol peroxidase and thioredoxin were markedly
higher than those in the wild-type, especially in stationary phase. The ustA mutant
was more resistant to diamide, a thiol-specific oxidant, than the wild-type. In
addition, the ustA mutation suppressed hypersensitivities of the oxyR mutant to
diamide, metronidazole and mitomycin C. These results suggest that UstA may play a
significant role in oxidative stress responses in the bacterium. © 2005 SGM.
AN - rayyan-563560848
AU - Kikuchi, Y.
AU - Ohara, N.
AU - Sato, K.
AU - Yoshimura, M.
AU - Yukitake, H.
AU - Sakai, E.
AU - Shoji, M.
AU - Naito, M.
AU - Nakayama, K.
DO - 10.1099/mic.0.27589-0
IS - 3
diamide
heat shock protein
metronidazole
mitomycin
oxygen
peroxidase
thioredoxin
unclassified drug
upregulated in stationary phase protein A
article
bacterial chromosome
bacterial genome
bacterial strain
bacterium culture
bacterium mutant
cistron
controlled study
culture medium
enzyme synthesis
gene disruption
gene location
gene mutation
gene sequence
nonhuman
Northern blotting
nucleotide sequence
oxidative stress
priority journal
protein analysis
protein function
strain difference
upregulation
wild type
LA - English
PY - 2005
SN - 1350-0872
SP - 841-853
ST - Novel stationary-phase-upregulated protein of Porphyromonas gingivalis
influences production of superoxide dismutase, thiol peroxidase and thioredoxin
T2 - Microbiology
TI - Novel stationary-phase-upregulated protein of Porphyromonas gingivalis
influences production of superoxide dismutase, thiol peroxidase and thioredoxin
VL - 151
ID - 14222
ER -
TY - JOUR
AB - Periodontitis is a bacterial infection. It appears in a generalised form but
more often appears in local areas in a patient's mouth or is reduced to localised
areas by mechanical treatment. Periodontitis lends itself well to treatment by
means of a controlled local delivery system using an antimicrobial agent. Several
products have been introduced or are in the process of clearing regulatory
agencies. It is the goal of all local delivery systems to deliver high
concentrations of an antimicrobial directly to the site of the periodontal
infection. Concentrations of medication can be achieved considerably higher than
could be obtained with systemic administration, while the systemic uptake of the
medication is minimal. Five local delivery systems (tetracycline fibre, doxycycline
polymer, chlorhexidine chip, minocycline ointment and metronidazole gel) are now
available. Techniques for their use and the supporting scientific evidence are
presented and indications for the use of the various systems are also discussed.
These local delivery systems offer the clinician additional therapeutic procedures
to aid in the treatment of the chronic inflammatory periodontal diseases.
AN - rayyan-563561028
AU - Killoy, W. J.
IS - 3
chlorhexidine
doxycycline
metronidazole
minocycline
polymer
tetracycline
chronic disease
drug implant
gel
human
microbiology
ointment
periodontitis
review
LA - English
PY - 1998
SN - 0020-6539
SP - 305-315
ST - Chemical treatment of periodontitis: local delivery of antimicrobials
T2 - Int Dent J
TI - Chemical treatment of periodontitis: local delivery of antimicrobials
VL - 48
ID - 14402
ER -
TY - JOUR
AB - This paper discusses differences between statistical and clinical
significance. It suggests nine factors to consider when assessing clinical
significance of periodontal therapy. The article reviews the multicentre randomized
clinical trials on the four antimicrobial local delivery systems commercially
available in the USA (tetracycline fibre, chlorhexidine chip, doxycycline gel and
minocycline microspheres) and assesses their data in relation to the nine factors
for clinical significance. Data from longitudinal studies comparing periodontal
surgery to non-surgery were evaluated in a similar fashion to provide a frame of
reference. It was concluded that the local delivery of an antimicrobial offers the
clinician a statistically and clinically significant option in the treatment of
chronic periodontitis. It is not an 'either/or' situation in selecting therapeutic
methods. It is a choice of which treatment method works best for that patient by
that clinician.
AN - rayyan-563560907
AU - Killoy, W. J.
chlorhexidine
chronic disease
clinical trial
comparative study
human
longitudinal study
multicenter study
periodontal disease
periodontitis
review
statistics
treatment outcome
LA - English
PY - 2002
SN - 0303-6979
SP - 22-29
ST - The clinical significance of local chemotherapies
TI - The clinical significance of local chemotherapies
VL - 29
ID - 14281
ER -
TY - COMP
AB - This paper discusses differences between statistical and clinical
significance. It suggests nine factors to consider when assessing clinical
significance of periodontal therapy. The article reviews the multicentre randomized
clinical trials on the four antimicrobial local delivery systems commercially
available in the USA (tetracycline fibre, chlorhexidine chip, doxycycline gel and
minocycline microspheres) and assesses their data in relation to the nine factors
for clinical significance. Data from longitudinal studies comparing periodontal
surgery to non-surgery were evaluated in a similar fashion to provide a frame of
reference. It was concluded that the local delivery of an antimicrobial offers the
clinician a statistically and clinically significant option in the treatment of
chronic periodontitis. It is not an 'either/or' situation in selecting therapeutic
methods. It is a choice of which treatment method works best for that patient by
that clinician.
AN - rayyan-563560982
AU - Killoy, W. J.
CY - United States
KW - Anti-Bacterial Agents/*administration & dosage
Anti-Infective Agents, Local/administration & dosage
Chlorhexidine/administration & dosage
Chronic Disease
*Drug Delivery Systems/statistics & numerical data
Humans
Longitudinal Studies
Multicenter Studies as Topic
Periodontal Diseases/*drug therapy/surgery
Periodontitis/drug therapy
Randomized Controlled Trials as Topic
Tetracyclines
Treatment Outcome
LA - eng
N1 - Department of Periodontology, University of Missouri, Kansas City, MO, USA.
billkilloy@aol.com
PY - 2002
SN - 0303-6979 (Print)
SP - 22-9
ST - The clinical significance of local chemotherapies
TI - The clinical significance of local chemotherapies
VL - 29
Y2 - 5
ID - 14356
ER -
TY - JOUR
AB - Five local delivery systems with five different antimicrobial agents have
been discussed. All are capable of delivering high concentrations of their
antimicrobial to the site of the periodontal infection. Although only one system,
tetracycline fiber, is available in United States, two other systems, chlorhexidine
chip and doxycycline polymer, may be available in the near future. Two other
systems, metronidazole gel and minocycline ointment, are available in other
countries. Data from pertinent studies were presented as were techniques for using
the various systems. Indications for the use of the products were also discussed.
In selecting the appropriate delivery system, the clinician has to weigh the
efficacy of the products, ease of use, availability, and cost. Although local
delivery systems do not replace existing periodontal therapies, they do have a
place in the treatment of periodontitis and offer the dentist additional methods to
aid in the control of periodontal diseases.
AN - rayyan-563561031
AU - Killoy, W. J.
AU - Polson, A. M.
IS - 2
chlorhexidine
doxycycline
drug vehicle
ethylenevinylacetate copolymer
metronidazole
minocycline
drug cost
Europe
gel
human
ointment
periodontitis
review
United States
vehicles
LA - English
PY - 1998
SN - 0011-8532
SP - 263-283
ST - Controlled local delivery of antimicrobials in the treatment of periodontitis
T2 - Dent. Clin. North Am.
TI - Controlled local delivery of antimicrobials in the treatment of periodontitis
VL - 42
ID - 14405
ER -
TY - JOUR
AB - The primary objective of this study was to evaluate the ability and mechanism
of action of kaempferol, which is contained in extracts from Nelumbo nucifera, a
well-known Oriental herb used in traditional medicine, with regard to the
inhibition of iNOS and TNF-α expression in aged rat gingival tissues. We conducted
an investigation into the age-related effects of kaempferol on reactive oxygen
species (ROS) and GSH oxidative status in samples of aged gingival tissues. Western
blotting was conducted in order to determine the expression of iNOS, TNF-α p38
MAPK, NIK/IKK, p65 and IκBα in the sample tissues. Electrophoretic mobility shift
assays (EMSA) were conducted in an effort to characterize the binding activities of
NF-κB transcription factors in the aged rat gingival nuclear extracts. Our results
indicate that kaempferol reduced ROS levels and augmented GSH levels in a dose-
dependent manner in the aged gingival tissues. Kaempferol was shown to effect a
significant reduction in iNOS and TNF-α protein levels, as compared to control
gingival tissue samples. The results of Western blot analysis revealed that
kaempferol treatment effected the reduction of iNOS and TNF-α expression, decreased
nuclear p65 and increased cytosolic p65, down-regulation of Erk, p38, JNK and
NIK/IKK expression. The EMSA results also indicated that kaempferol, when
administered to the rat tissues, attenuated the NF-κB nuclear binding activity.
Kaempferol may inhibit ROS generation via the inhibition of iNOS and TNF-α
expression in aged gingival tissues, via the modulation of the NF-κB and mitogen-
activated protein kinase (MAPK) pathways. © Springer Science+Business Media, Inc.
2007.
AN - rayyan-563560740
AU - Kim, H. K.
AU - Park, H. R.
AU - Lee, J. S.
AU - Chung, T. S.
AU - Chung, H. Y.
AU - Chung, J.
DO - 10.1007/s10522-007-9083-9
IS - 4
KW - glutathione
hydrogen peroxide
hydroxyl radical
I kappa B kinase alpha
I kappa B kinase
kaempferol
Nelumbo nucifera extract
plant extract
superoxide
synaptotagmin I
unclassified drug
aging
animal tissue
article
controlled study
cytosol
down regulation
drug dose comparison
drug mechanism
enzyme inhibition
gene inactivation
gingivitis
herbal medicine
male
Nelumbo
Nelumbo nucifera
nonhuman
oriental medicine
oxidative stress
priority journal
protein binding
protein expression
rat
Western blotting
LA - English
PY - 2007
SN - ["1389-5729", "1573-6768"]
SP - 399-408
ST - Down-regulation of iNOS and TNF-α expression by kaempferol via NF-κB
inactivation in aged rat gingival tissues
T2 - Biogerontology
TI - Down-regulation of iNOS and TNF-α expression by kaempferol via NF-κB
inactivation in aged rat gingival tissues
VL - 8
ID - 14114
ER -
TY - JOUR
AN - rayyan-563561841
AU - Kim, J.
AU - Hwang, J.
AU - Seo, Y.
AU - Jo, Y.
AU - Son, J.
AU - Choi, J.
DO - 10.1016/j.jiec.2016.10.017
PY - 2017
SP - 68-79
ST - Engineered chitosan–xanthan gum biopolymers effectively adhere to cells and
readily release incorporated antiseptic molecules in a sustained manner
T2 - Journal of Industrial and Engineering Chemistry
TI - Engineered chitosan–xanthan gum biopolymers effectively adhere to cells and
readily release incorporated antiseptic molecules in a sustained manner
85006054242&doi=10.1016%2fj.jiec.2016.10.017&partnerID=40&md5=c4cf67161a8ceab072149
8b1c34381e4
VL - 46
ID - 15215
ER -
TY - JOUR
AB - Periodontal disease is an oral disease common in middle-aged dogs and cats,
with halitosis being the most common sign. There are many commercial products
containing chlorhexidine, cetylpyridinium chloride (CPC), zinc salts and essential
oils for controlling halitosis and periodontal disease. CPC is a quaternary
ammonium compound and has a broad spectrum antimicrobial activity. In this study,
oral spray (OS) and gel (OG) containing CPC was applied to the dogs' teeth twice
daily for 3 weeks, and their effect in controlling periodontal disease and
halitosis was examined. In the 3-week study, OS and OG were significantly effective
in controlling plaque, calculus, and halitosis. Therefore, the OS and OG containing
CPC were effective in controlling periodontal disease and halitosis in dogs. ©
KSBB.
AN - rayyan-563560719
AU - Kim, S. E.
AU - Shim, K. M.
AU - Yoo, K. H.
AU - Kim, J. C.
AU - Kim, S. H.
AU - Bae, C. S.
AU - Kim, D.
AU - Park, D. H.
AU - Ryu, J. W.
AU - Kang, S. S.
DO - 10.1007/s12257-007-0074-0
IS - 2
aerosol
animal experiment
article
controlled study
dog
drug efficacy
gel
halitosis
mouth disease
nonhuman
periodontal disease
tooth calculus
tooth plaque
treatment duration
treatment outcome
LA - English
PY - 2008
SN - 1226-8372
SP - 252-255
ST - The effect of cetylpyridinium chloride on halitosis and periodontal disease-
related parameters in dogs
T2 - Biotechnol. Bioprocess Eng.
TI - The effect of cetylpyridinium chloride on halitosis and periodontal disease-
related parameters in dogs
VL - 13
ID - 14093
ER -
TY - JOUR
AB - Background: With the help of so-called controlled release delivery systems,
the half-life period of locally administered antibiotics in gingival crevicular
fluid (GCF) can be extended significantly. The aim of this study was to
characterize the delivery profile of a new one-component 14% doxycycline free amine
gel for local application. Pharmacokinetics of doxycycline (DOXY) were analyzed in
GCF, saliva, and serum. Methods: Twenty patients with persisting or recurring
pockets (probing depths ≥5 mm and bleeding on probing) after mechanical treatment
(surgical or non-surgical) took part in the study. In each patient 1 periodontal
defect was treated with DOXY gel. Samples of GCF, saliva, and serum were obtained
before application of DOXY gel; 15 minutes after application; at 2 and 5 hours; and
at 1, 2, 3, 4, 7, 9, and 11 days after application. Separation and quantitative
measurement of DOXY was performed with high performance liquid chromatography and
UV detection at λ = 260 nm. Results: Coefficients of variation were lower than 2%
(intraassay) and 4% (interassay), respectively. For concentrations between 50 to
1000 μg/ml, we found a linear relationship between expected and measured DOXY
values (linear coefficient of correlation: r = 0.998). Within the first 5 hours
after application, concentration of DOXY in GCF (maximum after 15 minutes 19.97 ±
5.85 mg/ml) and saliva (maximum after 15 minutes 17.83 ± 2.84 mg/ml) was similar.
Then concentration fell to a lower level (28.90 ± 19.44 μg/ml) compared to GCF
(577.41 ± 127.34 gg/ml) after 3 days. Up to 10 days after application, the
concentration of DOXY in GCF was 34.24 μg/ml. With the exception of 1 patient, all
serum samples were DOXY-negative. Conclusions: 1) After subgingival application of
biodegradable 14% doxycycline gel, mean doxycycline levels in GCF that exceeded 16
μg/ml could be maintained for at least 12 days. Thus, the antimicrobial agent may
be classified as a controlled release device. 2) The antibiotic effect was limited
mainly to the subgingival sites of application of the doxycycline gel. 3) The
doxycycline gel possesses the pharmacokinetic and clinical properties to deliver
efficacious levels of antibiotics to the periodontal pocket and to maintain these
levels for at least 1 week without the need of further drug retention by a
periodontal dressing.
AN - rayyan-563560896
AU - Kim, T. S.
AU - Bürklin, T.
AU - Schacher, B.
AU - Renggli, H. H.
AU - Fiehn, W.
AU - Eickholz, P.
DO - 10.1902/jop.2002.73.11.1285
IS - 11
chlorhexidine
doxycycline
metronidazole
minocycline
tetracycline
adult
article
blood sampling
clinical article
controlled study
devices
dose time effect relation
drug blood level
drug determination
drug effect
drug efficacy
drug half life
drug retention
drug saliva level
female
gastrointestinal toxicity
gel
gingivitis
human
male
periodontitis
radiation detection
LA - English
PY - 2002
SN - 0022-3492
SP - 1285-1291
ST - Pharmacokinetic profile of a locally administered doxycycline gel in
crevicular fluid, blood, and saliva
TI - Pharmacokinetic profile of a locally administered doxycycline gel in
VL - 73
ID - 14270
ER -
TY - JOUR
AB - Background: With the help of so-called controlled release delivery systems,
the half-life period of locally administered antibiotics in gingival crevicular
fluid (GCF) can be extended significantly. The aim of this study was to
characterize the delivery profile of a new one-component 14% doxycycline free amine
gel for local application. Pharmacokinetics of doxycycline (DOXY) were analyzed in
GCF, saliva, and serum. Methods: Twenty patients with persisting or recurring
pockets (probing depths 5 mm and bleeding on probing) after mechanical treatment
(surgical or non-surgical) took part in the study. In each patient 1 periodontal
defect was treated with DOXY gel. Samples of GCF, saliva, and serum were obtained
before application of DOXY gel; 15 minutes after application; at 2 and 5 hours; and
at 1, 2, 3, 4, 7, 9, and 11 days after application. Separation and quantitative
measurement of DOXY was performed with high performance liquid chromatography and
UV detection at lambda = 260 nm. Results: Coefficients of variation were lower than
2% (intraassay) and 4% (interassay), respectively. For concentrations between 50 to
1000 mug/ml, we found a linear relationship between expected and measured DOXY
values (linear coefficient of correlation: r = 0. 98). Within the first 5 hours
after application, concentration of DOXY in GCF (maximum after 15 minutes 19.97 +/-
5.85 mg/ml) and saliva (maximum after 15 minutes 17.83 +/- 2.84 mg/ml) was similar.
Then concentration fell to a lower level (28.90 +/- 19.44 mug/ml) compared to GCF
(577.41 +/- 127.34 mug/ml) after 3 days. Up to 10 days after application, the
concentration of DOXY in GCF was 34.24 mug/ml. With the exception of 1 patient, all
serum samples were DOXY-negative. Conclusions: 1) After subgingival application of
biodegradable 14% doxycycline gel, mean doxycycline levels in GCF that exceeded 16
mug/ml could be maintained for at least 12 days. Thus, the antimicrobial agent may
be classified as a controlled release device. 2) The antibiotic effect was limited
mainly to the subgingival sites of application of the doxycycline gel. 3) The
doxycycline gel possesses the pharmacokinetic and clinical properties to deliver
efficacious levels of antibiotics to the periodontal pocket and to maintain these
levels for at least I week without the need of further drug retention by a
periodontal dressing.
AN - rayyan-563562444
AU - Kim, T. S.
AU - Burklin, T.
AU - Schacher, B.
AU - Ratka-Kruger, P.
AU - Renggli, H. H.
AU - Fiehn, W.
AU - Eickholz, P.
DO - 10.1902/jop.2002.73.11.1285
IS - 11
PY - 2002
SN - 0022-3492
SP - 1285-1291
ST - Pharmacokinetic profile of a locally administered doxycycline gel in
TI - Pharmacokinetic profile of a locally administered doxycycline gel in
VL - 73
Y2 - 11
ID - 15818
ER -
TY - JOUR
AB - BACKGROUND: Controlled-release delivery systems enable the clinician to
extend the half-life period of locally administered antibiotics in gingival
crevicular fluid (GCF) significantly. The aim of this split-mouth study was to
compare the pharmacokinetic profile of two different doxycycline gels (DOXY and
ATRI) for topical subgingival application. Pharmacokinetics of both doxycycline
gels were analyzed in GCF and saliva. METHODS: In 10 patients suffering from severe
periodontitis, 10 pairs of contralateral defects (pocket depth > or =5 mm/bleeding
on probing or > or =6 mm) were randomly assigned either to the first application of
DOXY or ATRI. Fourteen days after the topical application of the first antibiotic
gel, the application of the second gel in the contralateral defect took place.
Clinical examinations at baseline showed no significant differences between sites
treated with DOXY and ATRI. Samples of GCF and saliva were drawn baseline, 2, 5 and
24 h after application, 2, 3, 4, 7, 9 and 11 days after application. Separation and
quantitative measurement of both doxycycline-gels was performed with HPLC- and UV-
detection at lambda=260 nm. RESULTS: In saliva specimens, time-dependent changes of
mean doxycycline concentration were almost identical for both doxycycline-gels and
declined from a maximum 2 h after application (ATRI: 6653.90+/-3096.14 microg/ml;
DOXY: 5386.60+/-1542.02 microg/ml [arithmetic mean+/-SEM]) to zero values 9 days
after application. In crevicular fluid specimens, sites treated with ATRI exhibited
a faster decrease of mean doxycycline concentration (1085.30, 264.00, 273.94, and
258.00 microg/ml measured 2, 5, 24, and 48 h after application) than sites treated
with DOXY (1388.38, 1300.40, 803.73, and 235.10 microg/ml). The faster decrease of
ATRI compared with DOXY could not be proved to be statistically significantly
different. CONCLUSIONS: Both doxycycline gels showed pharmacokinetics of
controlled-release delivery systems.
AN - rayyan-563560867
AU - Kim, T. S.
AU - Klimpel, H.
AU - Fiehn, W.
AU - Eickholz, P.
IS - 4
doxycycline
doxycycline hyclate
drug derivative
article
clinical trial
comparative study
controlled study
female
follow up
gel
gingivitis
human
male
metabolism
middle aged
periodontitis
saliva
LA - English
PY - 2004
SN - 0303-6979
SP - 286-292
ST - Comparison of the pharmacokinetic profiles of two locally administered
doxycycline gels in crevicular fluid and saliva
TI - Comparison of the pharmacokinetic profiles of two locally administered
doxycycline gels in crevicular fluid and saliva
VL - 31
ID - 14241
ER -
TY - JOUR
AB - Objectives. Controlled release delivery (CRD) systems are used to extend the
half-life of topical antibiotics in gingival crevicular fluid (GCF), while avoiding
systemic contamination with antibiotics. When multiple periodontitis sites are
treated by subgingival application of a one-component copolymer gel containing 14%
doxycycline, it is likely that low levels of the antibiotic can be detected in
blood by high performance liquid chromatography (HPLC). Methods. Twelve patients
with severe periodontitis and one single defect per patient were treated with one
single subgingival application of a new one-component doxycycline gel (14%) in each
defect (the UNISITE group). Furthermore, 12 patients with between 3 and 9
periodontal defects were treated with a single application of the same doxycycline
gel in each defect, resulting in 3-9 applications per patient (the MULTISITE
group). Doxycycline was separated and quantitatively measured with HPLC using a UV
detector. Results. In saliva, the maximum doxycycline concentration of the
MULTISITE patients was nearly 10-fold higher than in the UNISITE group. In GCF
specimens, maximum doxycycline concentrations were the same magnitude in both the
MULTISITE and UNISITE groups. Only one UNISITE patient showed detectable levels of
doxycycline in blood serum (maximum application: 0.18 μg/ml). Six MULTISITE
patients exhibited measurable concentrations of doxycycline in their serum samples
(maximum values: 0.120.76 μg/ml). The mean systemic concentration following
application of the doxycycline-containing gel to multiple sites was as high as 160
ng/ml within minutes following application. Within approximately 1 h, this fell to
levels below the limit of detection by HPLC (<50 ng/ml). Conclusions. Systemic
contamination with doxycycline after topical administration may occur even after
unisite application if no periodontal dressing is used. Locally administered
doxycycline can be identified in the systemic circulation at levels far below those
expected to have antibacterial effects. Systemic concentration following
application to a single site was always below levels capable of detection by HPLC.
© 2009 Informa UK Ltd.
AN - rayyan-563560654
AU - Kim, T. S.
AU - Lee, S. H.
AU - Eickholz, P.
AU - Zimmer, H.
AU - Kim, C. K.
DO - 10.1080/00016350903001841
IS - 5
KW - doxycycline
Ivoclar
unclassified drug
adult
article
clinical article
controlled study
drug absorption
drug blood level
drug saliva level
female
gingivitis
human
male
periodontitis
LA - English
PY - 2009
SN - ["0001-6357", "1502-3850"]
SP - 289-296
ST - Systemic detection of doxycycline after local administration
TI - Systemic detection of doxycycline after local administration
VL - 67
ID - 14028
ER -
TY - JOUR
AB - Feline hemotropic mycoplasmosis (hemoplasmosis) is an infection of the red
blood cells caused by the Mycoplasma haemofelis (Mhf), Candidatus Mycoplasma
haemominutum (CMhm), and Candidatus Mycoplasma turicensis (CMt). The existence of
Mhf, CMhm, and CMt has been demonstrated in feral cats in Korea using molecular
methods, but no clinical cases have yet been reported. This study reports 2
clinical cases of hemotropic mycoplasmosis caused by CMhm and CMt in 2 anemic cats.
The first case was a client-owned intact female domestic shorthair cat that
presented with fever, pale mucous membranes, and normocytic normochromic non-
regenerative anemia. Prior to referral, an immunosuppressive prednisolone dose was
administered at the local veterinary clinic for 1 month. The cat was diagnosed with
high-grade alimentary lymphoma. Organisms were found on the surface of the red
blood cells on blood smear examination. The second case was of a rescued cat that
presented with dehydration and fever. The cat had normocytic normochromic non-
regenerative anemia. Necropsy revealed concurrent feline infectious peritonitis.
Polymerase chain reaction assay targeting 16S rRNA revealed CMhm infection in case
1 and dual infection of CMhm and CMt in case 2. Normocytic normochromic non-
regenerative anemia was observed in both cats before and during the management of
the systemic inflammation. This is the first clinical case report in Korea to
demonstrate CMhm and CMt infections in symptomatic cats.
AN - rayyan-563559870
AU - Kim, Y. J.
AU - Bae, H.
AU - Shin, S. W.
AU - Cho, A.
AU - Jeon, Y.
AU - Hwang, T. S.
AU - Jung, D. I.
AU - Kim, D. Y.
AU - Kang, J. G.
AU - Yu, D.
DO - 10.3347/kjp.2022.60.2.127
IS - 2
KW - DNA Analyzer
FIPV3 70
hematrocrit centrifuge
intron
multiple antinuclear antibody test kit
nasoesophageal tube
contrast medium
doxycycline
hemoglobin
Human immunodeficiency virus antibody
plasmid DNA
prednisolone
RNA 16S
abdominal mass
abdominal wall
adult
alimentary lymphoma
anemia
animal experiment
animal model
article
autopsy
blood cell count
blood smear
bootstrapping
Candidatus Mycoplasma haemominutum
Candidatus Mycoplasma turicensis
centrifugation
chondrocostal junction
clinical assessment
controlled study
dehydration
DNA sequence
enteric feeding
eperythrozoonosis
erythrocyte
euthanasia
feline infectious peritonitis
female
fever
fine needle aspiration biopsy
fluid resuscitation
gingivitis
hematocrit
hepatic lymph node
intestinal mass
intestine perforation
jejunum wall thickening
Korea
leukocytosis
lymphoma
maximum likelihood method
molecular biology
molecular identification
mucosal disease
multifocal granulomatous lesion
multiplex polymerase chain reaction
Mycoplasma haemofelis
nonhuman
nucleotide sequence
pathologic nystagmus
pancreaticoduodenal
peritoneal effusion
phylogenetic tree
platelet count
purulent oculonasal discharge
reticulocyte count
rivalta test
seizure
shorthair cat
tachycardia
tachypnea
tooth calculus
veterinarian
veterinary clinic
iNtRON
QIAamp
LA - English
PY - 2022
SN - ["1738-0006", "0023-4001"]
SP - 127-131
ST - Two Clinical Cases of Feline Hemoplasmosis in Korea
T2 - Korean J. Parasitol.
TI - Two Clinical Cases of Feline Hemoplasmosis in Korea
VL - 60
ID - 13244
ER -
TY - JOUR
AB - Tannerella forsythia is considered a pathogen of periodontitis and forms a
biofilm with multi-species bacteria in oral cavity. Lipopolysaccharide is a
powerful immunostimulator and induces inflammation and shock. The purpose of this
study was to investigate the characteristics of T. forsythia LPS in its co-
cultivation with Fusobacterium nucleatum or Porphyromonas gingivalis. T. forsythia
was co-cultured in the presence and absence of F. nucleatum and P. gingivalis and
then T. forsythia LPS was extracted. The extracts were analyzed by SDS-PAGE and NF-
κB reporter CHO cell lines. THP-1 cells were treated with the LPS and evaluated
induction of cytokine expression by real-time RT-PCR and ELISA. For analysis of the
bioactivity of T. forsythia LPS, the binding assay on LPS-binding protein (LBP) and
CD14 was processed. The extracts did not contaminate other molecules except LPS and
showed TLR4 agonists. Co-cultured T. forsythia LPS with P. gingivalis exhibited a
lower level of induction of TNF-α, IL-1β, and IL-6 expression than single- or co-
cultured T. forsythia LPS with F. nucleatum in the conditions of human serum.
However, the three T. forsythia LPS did not show difference of cytokine induction
in the serum free conditions. Co-cultured T. forsythia LPS with P. gingivalis
exhibited a lower affinity to LBP and CD14 as binding site of O-antigen and
attached at a lower level to THP-1 cells compared to single- or co-cultured T.
forsythia LPS with F. nucleatum. The virulence of T. forsythia LPS was decreased by
co-culturing with P. gingivalis and their affinity to LBP and CD14 was reduced,
which may due to modification of O-antigen chain by P. gingivalis.
AN - rayyan-563560421
AU - Kim, Y. J.
AU - Lee, S. H.
DO - 10.1007/s12275-014-4324-5
IS - 8
KW - acute phase protein
carrier protein
CD14 antigen
cytokine
IL1B protein, human
interleukin 1beta
interleukin 6
lipopolysaccharide
lipopolysaccharide binding protein
membrane protein
antagonists and inhibitors
Bacteroidetes
biosynthesis
cell line
coculture
human
immunology
metabolism
organismal interaction
pathogenicity
physiology
LA - English
PY - 2014
SN - 1976-3794
SP - 702-708
ST - Reducing the bioactivity of Tannerella forsythia lipopolysaccharide by
T2 - J. Microbiol.
TI - Reducing the bioactivity of Tannerella forsythia lipopolysaccharide by
VL - 52
ID - 13795
ER -
TY - JOUR
AB - Dental plaque, a microbial biofilm that accumulates on teeth and initiates
periodontal disease, is composed of hundreds of different bacterial species within
an organized structure. The biofilm bacteria and their byproducts irritate the
gingival epithelium and induce an "inflammatory response". The perturbation of
epithelial cells by bacteria is the first stage in the initiation of inflammatory
and immune processes which eventually cause destruction of the tissues surrounding
and supporting the teeth, and ultimately result in tooth loss. This review
addresses the early bacterial-epithelial cell interactions and the subsequent
responses of the epithelial cell. It includes discussion of how epithelial Toll-
like receptors (TLRs) respond to different bacterial challenges, the variable
antimicrobial peptides released and the host signaling responses which trigger
release of these molecules and the overall fate of these cells in terms of
survival, apoptosis, or cell lysis.
AN - rayyan-563562582
AU - Kinane, D. F.
AU - Galicia, J. C.
AU - Gorr, S. U.
AU - Stathopoulou, P. G.
AU - Benakanakere, M.
DO - 10.2741/2736
PY - 2008
SN - ["1093-9946", "1093-4715"]
SP - 966-984
ST - P. gingivalis interactions with epithelial cells
T2 - FRONTIERS IN BIOSCIENCE-LANDMARK
TI - P. gingivalis interactions with epithelial cells
VL - 13
Y2 - 1 y3 - 1
ID - 15956
ER -
TY - JOUR
AB - The aim of this investigation was to evaluate the effect of smoking on the
outcome of periodontal therapy. The study consisted of 54 patients who participated
in a 4-group parallel-arm clinical trial on the efficacy of three locally delivered
antimicrobial systems as adjuncts to scaling and root planing in the treatment of
sites with persistent pocketing after a course of scaling and root planing. These
groups included scaling and root planing either alone (S) (n = 3), or in
conjunction with the application of 25% tetracycline fibers (S&T) (n = 13), 2%
minocycline gel (S&Mi) (n = 14), or 25% metronidazole gel (S&Me) (n = 14). In each
patient four pockets > 5 mm with bleeding on probing (BOP) and/or suppuration were
studied. The number of subjects who smoked was: 8 (61.5%) in the S&T group, 8
(57.1%) in the S&Mi group, 6 (42.9%) in the S&Me group, and 6 (46.2%) in the S
group. The probing depth, attachment level and other clinical parameters were
assessed at baseline and 6 weeks after treatments. The clinical results of this
comparative study have been previously reported. Regardless of the type of
treatment, the change in the probing depth (delta PD) and attachment gain (delta
AL) were greater in non-smoker subjects than smoker subjects. delta PD was 1.14 mm
versus 0.76 mm (P = 0.019), and delta AL was 0.52 mm versus 0.50 mm at (P = 0.845)
for non-smokers and smokers respectively. The analysis of variance using the
general linear model (GLM) was used for delta PD and delta AL and took into account
the variations in the treatments, number of smoker subjects per group, and baseline
probing depth. There was a significant interaction between the "smoking" and the
"baseline PD." Further analysis using linear regression indicated that, while there
was a significant relationship between the baseline PD and the delta PD or delta AL
among the non-smokers, weak and insignificant relationship existed among the smoker
subjects. Thus, smoking may have an important role in determining the prognosis of
periodontal treatment, particularly in persistent and deep pockets.
AN - rayyan-563560944
AU - Kinane, D. F.
AU - Radvar, M.
DO - 10.1902/jop.1997.68.5.467
IS - 5
J2 - J Periodontol
KW - Adult
Analysis of Variance
Anti-Bacterial Agents/therapeutic use
Dental Plaque Index
Dental Scaling
Female
Humans
Linear Models
Male
Metronidazole/therapeutic use
Middle Aged
Minocycline/therapeutic use
Outcome Assessment, Health Care
Periodontal Index
Periodontal Pocket/*complications/*therapy
Prognosis
Root Planing
Smoking/*adverse effects
Tetracycline/therapeutic use
LA - eng
N1 - Periodontal Department, Glasgow Dental School, Scotland, UK.
PY - 1997
SN - 0022-3492 (Print)
SP - 467-72
ST - The effect of smoking on mechanical and antimicrobial periodontal therapy
TI - The effect of smoking on mechanical and antimicrobial periodontal therapy
VL - 68
Y2 - 5
ID - 14318
ER -
TY - JOUR
AB - BACKGROUND: Currently, several local antimicrobial delivery systems are
available to periodontists. The aim of this 6-month follow-up parallel study was to
evaluate the efficacy of three commercially available local delivery systems as
adjuncts to scaling and root planing in the treatment of sites with persistent
periodontal lesions. METHODS: Seventy-nine patients with 4 pockets > or = 5 mm and
bleeding on probing and/or suppuration were randomized into 4 treatment groups
which included: scaling and root planing alone (S) (20 patients), or in conjunction
with the application of 25% tetracycline fibers (S+Tet) (19 patients), or 2%
minocycline gel (S+Min) (21 patients), or 25% metronidazole gel (S+Met) (19
patients). Clinical measurements were taken at baseline, 6 weeks, 3 months, and 6
months after antimicrobial application. Treatments were applied using the
distributors' recommended protocols. RESULTS: All 4 therapies resulted in
significant improvements from baseline in probing depth, attachment level, bleeding
on probing, and the Modified Gingival Index (MGI) scores. The improvements in
clinical parameters were greater in all 3 adjunctive treatment groups than scaling
and root planing alone. The mean probing depth reductions at 6 months were: scaling
+ tetracycline = 1.38 mm; scaling + metronidazole = 0.93 mm; scaling + minocycline
= 1.10 mm; and scaling alone = 0.71 mm. The probing depth reduction at all time
points was significantly greater in the scaling plus tetracycline fiber group than
the scaling and root planing alone group (P<0.01). There was also a significant
improvement for scaling plus tetracycline fiber application over scaling and
metronidazole at both 6 weeks and 3 months, although this did not remain
significant at the 6-month visit. While the frequency of sites with suppuration was
markedly reduced following all antimicrobial treatments, the most effective
reductions were seen in the scaling plus tetracycline fiber group, followed by the
minocycline group. CONCLUSIONS: Although all 3 locally applied antimicrobial
systems seem to offer some benefit over scaling and root planing alone, a treatment
regimen of scaling and root planing plus tetracycline fiber placement gave the
greatest reduction in probing depth over the 6 months after treatment.
AN - rayyan-563561219
AU - Kinane, D. F.
AU - Radvar, M.
DO - 10.1902/jop.1999.70.1.1
IS - 1
J2 - J Periodontol
KW - Adult
Chronic Disease
Dental Scaling
Female
Follow-Up Studies
Gels
Humans
Linear Models
Male
Metronidazole/*administration & dosage
Middle Aged
Minocycline/*administration & dosage
Periodontal Index
Tetracycline/*administration & dosage
Treatment Outcome
LA - eng
N1 - Adult Dental Care Department, Glasgow Dental Hospital and School, Scotland,
UK.
PY - 1999
SN - 0022-3492 (Print)
SP - 1-7
ST - A six-month comparison of three periodontal local antimicrobial therapies in
persistent periodontal pockets
TI - A six-month comparison of three periodontal local antimicrobial therapies in
persistent periodontal pockets
VL - 70
Y2 - 1
ID - 14593
ER -
TY - JOUR
AB - Background: Currently, several local antimicrobial delivery systems are
available to periodontists. The aim of this 6-month follow-up parallel study was to
evaluate the efficacy of three commercially available local delivery systems as
adjuncts to scaling and root planing in the treatment of sites with persistent
periodontal lesions. Methods: Seventy-nine patients with 4 pocket ≥ 5 mm and
bleeding on probing and/or suppuration were randomized into 4 treatment groups
which included: scaling and root planing alone (S) (20 patients), or in conjunction
with the application of 25% tetracycline fibers (S+Tet) (19 patients), or 2%
minocycline gel (S+Min) (21 patients), or 25% metronidazole gel (S+Met) (19
patients). Clinical measurements were taken at baseline, 6 weeks, 3 months, and 6
months after antimicrobial application. Treatments were applied using the
distributors' recommended protocols. Results: All 4 therapies resulted in
significant improvements from baseline in probing depth, attachment level, bleeding
on probing, and the Modified Gingival Index (MGI) scores. The improvements in
clinical parameters were greater in all 3 adjunctive treatment groups than scaling
and root planing alone. The mean probing depth reductions at 6 months were: scaling
+ tetracycline = 1.38 mm; scaling + metronidazole = 0.93 mm; scaling + minocycline
= 1.10 mm; and scaling alone = 0.71 mm. The probing depth reduction at all time
points was significantly greater in the scaling plus tetracycline fiber group than
the scaling and root planing alone group (P<0.01). There was also a significant
improvement for scaling plus tetracycline fiber application over scaling and
metronidazole at both 6 weeks and 3 months, although this did not remain
significant at the 6-month visit. While the frequency of sites with suppuration was
markedly reduced following all antimicrobial treatments, the most effective
reductions were seen in the scaling plus tetracycline fiber group, followed by the
minocycline group. Conclusions: Although all 3 locally applied antimicrobial
systems seem to offer some benefit over scaling and root planing alone, a treatment
regimen of scaling and root planing plus tetracycline fiber placement gave the
greatest reduction in probing depth over the 6 months after treatment.
AN - rayyan-563561010
AU - Kinane, D. F.
AU - Radvar, M.
DO - 10.1902/jop.1999.70.1.1
IS - 1
KW - ethylene vinyl acetate copolymer
metronidazole
minocycline
tetracycline
article
bleeding
clinical trial
controlled study
female
fiber
gel
human
male
periodontitis
LA - English
PY - 1999
SN - 0022-3492
SP - 1-7
ST - A six-month comparison of three periondontal local antimicrobial therapies in
persistent periondontal pockets
TI - A six-month comparison of three periondontal local antimicrobial therapies in
persistent periondontal pockets
VL - 70
ID - 14384
ER -
TY - JOUR
AB - Gingival enlargement [GE] can be attributed to dental plaque induced
inflammatory disease which may be further influenced by hormonal , nutritional ,
blood dysgrasia associated factors and systemic drug use. Anticonvulsants,
immunosupressants, and calcium channel blockers are known to influence the clinical
progression of plaque induced inflammatory GE . GE influenced by CCB Amlodipine may
develop within months of administration and present with connective tiisue
lymphoplasmacytic infiltrates on histopathologic evaluation. Lymphoplasmacytic
infiltrates are also seen in plasma cell disorders, plasma cell gingivitis,
leukemia, hodgkins lymphoma, multiple myeloma and hepatitis C infection may pose as
possible differential diagnoses. In this case report an Amlodipine induced GE which
presented with the histopathological features of a lymphoplasmacytic lesion was
managed by non-surgical periodontal therpay and drug substitution leading to the
subsequent resolution of both the clinical lesion and lymphoplasmacytic infiltrate
upon histopathologic investigation during follow up period over one year.
AN - rayyan-563559924
AU - Kini, V. V.
AU - Dekate, K.
AU - Londhe, P. C.
AU - Sukalkar, S. M.
AU - Waghmare, S. V.
DO - 10.47750/pnr.2022.13.S10.218
KW - amlodipine
amoxicillin
chlorhexidine
gel
meclozine
metronidazole
mouthwash
telmisartan
adult
article
bleeding time
blood clotting time
case report
chewing tobacco
clinical article
differential diagnosis
drug substitution
female
giant cell granuloma
gingiva bleeding
gingiva overgrowth
gingival biopsy
gingivitis
hematology
human
human tissue
hypertension
interdental papilla
lymphadenopathy
menopause
middle aged
mouth hygiene
osteolysis
panoramic radiography
periodontitis
root planing
serology
swelling
tooth radiography
urinalysis
vertigo
LA - English
PY - 2022
SN - ["2229-7723", "0976-9234"]
SP - 1897-1901
ST - Drug Influenced Gingival Enlargement Presenting As A Lymphoplasmacytic
Lesion: A Case Report
TI - Drug Influenced Gingival Enlargement Presenting As A Lymphoplasmacytic
Lesion: A Case Report
VL - 13
ID - 13298
ER -
TY - JOUR
AB - The objective of this study was to develop an improved drug delivery system
for the local antimicrobial treatment of periodontitis, that offers enhanced drug
stability, easy application and controlled release over several weeks. Chelate
complexes consisting of a tetracycline antibiotic and a fatty acid salt were
developed. Minocycline and doxycycline were paired with magnesium- and calcium
stearate in different molar ratios. These chelate complexes stabilize the active
pharmaceutical ingredient and enable the incorporation into a PLGA (poly (lactic-
co-glycolic acid)) polymer matrix via hot melt extrusion. The chelate complexes
were characterized via UV/Vis- and IR-spectroscopy. A high antibiotic activity of
the complex was observed in a disc diffusion test. The drug complex was mixed with
different PLGA-polymers and cryomilled in advance of the extrusion. The hot melt
extrusion yielded homogeneous extrudates with a diameter from 600 to 900 mu m. They
contain 11.5% of minocycline, are adjustable in length and are easy to handle. In
vitro release studies revealed a controlled release of the drug over 42 days. In
conclusion, the developed extrudates are promising systems to improve the treatment
of periodontitis.
AN - rayyan-563562385
AU - Kirchberg, M.
AU - Eick, S.
AU - Buchholz, M.
AU - Kiesow, A.
AU - Sarembe, S.
AU - Mader, K.
DO - 10.1016/j.ijpharm.2019.118794
PY - 2019
SN - ["0378-5173", "1873-3476"]
ST - Extrudates of lipophilic tetracycline complexes: A new option for
periodontitis therapy
TI - Extrudates of lipophilic tetracycline complexes: A new option for
VL - 572
Y2 - 12 y3 - 15
ID - 15759
ER -
TY - JOUR
AB - OBJECTIVE: To evaluate the influence of reservoirs on the gingival mucosa of
patients submitted to at-home bleaching with 16% carbamide peroxide. METHOD AND
MATERIALS: Nineteen nonsmoking male patients, 18 to 25 years of age, were submitted
to home bleaching with a 16% carbamide peroxide gel for 2 consecutive hours for 21
days. The custom-made mouth trays were made with a reservoir on only the left side
and cut anatomically 1 mm beyond the gingival margin. Smears of the gingival mucosa
were obtained by the exfoliation cytology in liquid media technique before
(control), immediately after, and 30 and 45 days after treatment. The samples were
processed in the laboratory and evaluated according to Papanicolaou's criteria of
malignity. Statistical analysis was carried out by McNemar test, 2 proportions
test, and Wilcoxon test with a level of significance of 1%. RESULTS: The presence
of a reservoir in the custom tray resulted in an increase of inflammation only
immediately after the bleaching procedure. After 30 and 45 days, the difference
between inflammation on the sides with and without a reservoir was not
statistically significant. Significant differences were found in the degree of
inflammation, classified as predominantly mild on the nonreservoir side and
moderate on the reservoir side (P < .01). CONCLUSIONS: A 16% carbamide peroxide
bleaching gel caused gingival inflammation immediately after the procedure and
persisted until 45 days after the bleaching treatment. The use of a reservoir in
the custom tray for home bleaching resulted in higher rates and higher intensity of
gingival inflammation.
AN - rayyan-563560682
AU - Kirsten, G. A.
AU - Freire, A.
AU - de Lima, A. A.
AU - Ignácio, S. A.
AU - Souza, E. M.
IS - 3
oxidizing agent
peroxide
urea
carbamide peroxide
adolescent
adult
article
cytodiagnosis
dental procedure
dental device
drug combination
drug effect
gingivitis
human
devices
male
methodology
mouth mucosa
LA - English
PY - 2009
SN - 1936-7163
SP - 195-202
ST - Effect of reservoirs on gingival inflammation after home dental bleaching
TI - Effect of reservoirs on gingival inflammation after home dental bleaching
VL - 40
ID - 14056
ER -
TY - JOUR
AB - Background The concentration and persisting time of antimicrobial agents in
the periodontal pockets are important factors for their antimicrobial efficacy.
Increased clearance time in the periodontal pocket is a significant criterion for
the selection of intrapocket irrigants. The aim of this study was to estimate the
clearance time of a cationic agent from the periodontal pocket. Methods Thallium-
201(Tl-201) was chosen as a tracer to simulate the clearance of cationic substance
because of its electrical activity. Twenty patients with periodontitis and probing
depths 6 to 9 mm were included in this study. In each patient, 3 Mega Becquerel
(MBq) of Tl-201 were inserted into the periodontal pocket. Dynamic imaging was
performed and clearance of radioactivity was measured. Results Clearance of
radioactivity was 67.1 +/- 16.9, 83.1 +/- 13.9, 90.4 +/- 10.4, 93.39 +/- 8.0% at
30, 60, 90 and 120 min, respectively. Half-life of wash-out was determined as 20.3
+/- 10.2 min. Conclusion The results of this study demonstrate that the half-life
of the cationic solution applied subgingivally was approximately 20 min and
labelling of oral irrigants with radiotracers may be used to determine their
clearance in further research.
AN - rayyan-563562305
AU - Kirtiloglu, T.
AU - Keskiner, I.
AU - Sahin, M.
AU - Kirtiloglu, B.
AU - Aygul, S.
AU - Sakallioglu, U.
AU - Acikgoz, G.
DO - 10.1186/s12903-019-0998-8
IS - 1
PY - 2020
SN - 1472-6831
ST - Assessment of the half-life of cationic periodontal pocket irrigation
T2 - BMC ORAL HEALTH
TI - Assessment of the half-life of cationic periodontal pocket irrigation
VL - 20
Y2 - 1 y3 - 8
ID - 15679
ER -
TY - JOUR
AB - Objective: The aim of this study was to compare the influence of topical
metronidazole gel application and scaling and root planing on gingival crevicular
fluid variables. Method and Materials: In a split-mouth study, 39 volunteers with
chronic periodontitis were treated by metronidazole gel or scaling and root
planing. Clinical attachment level and probing depth were recorded, and aspartate
aminotransferase (AST) and total/transformed alpha 2-macroglobulin were determined
in the gingival crevicular fluid at baseline, as well as after 3 and 6 months.
Results: Both treatment procedures resulted in a gain of clinical attachment-0.67
mm for metronidazole and 0.50 mm for scaling and root planing (P <.001)-at the end
of the study. The median probing depth was significantly reduced by 0.66 mm for
metronidazole and 1.00 mm for scaling and root planing (P < .001) after 6 months.
No change of AST was found. Alpha2-macroglobulin was significantly reduced for
scaling and root planing and metronidazole after 3 and 6 months (P < .001). No
significant difference was found between the 2 procedures at any variable.
Conclusions: These data suggest that alpha2-macroglobulin reflects clinical changes
better than AST and that metronidazole and scaling and root planing have the same
influence on clinical outcome and biochemical variables in the gingival crevicular
fluid.
AN - rayyan-563560708
AU - Knöfler, G.
AU - Purschwitz, R.
AU - Jentsch, H.
AU - Birkenmeier, G.
AU - Schmidt, H.
IS - 5
KW - alpha 2 macroglobulin
metronidazole
adult
article
chemistry
clinical trial
controlled study
female
gingivitis
human
male
metabolism
nonparametric test
periodontics
LA - English
PY - 2008
SN - 0033-6572
SP - 381-389
ST - Gingival crevicular fluid levels of aspartate aminotransferase and alpha2-
macroglobulin before and after topical application of metronidazole or scaling and
root planing
TI - Gingival crevicular fluid levels of aspartate aminotransferase and alpha2-
macroglobulin before and after topical application of metronidazole or scaling and
root planing
VL - 39
ID - 14082
ER -
TY - JOUR
AB - Eight randomized clinical trials, comparing the application of 25%
metronidazole dental gel (Elzylol dental gel) once a week for two weeks with
scaling and root planing in the "split-mouth" design for treating adult
periodontitis, were evaluated and scored according to ANTCZAK et al. (1986) and
BEGG et al. (1996). The aim of this investigation was to determine whether both
treatment methods are of equal value. With a maximum of 1.0 in each case, the
scores determined were (M +/- SD) 0.107 +/- 0.033 (range 0.072-0.168) for reporting
the study protocol and 0.285 +/- 0.084 (range 0.120-0.400) for the data analysis,
presentation and discussion. Though the study results show that both treatment
modalities are of equal value, the quality of the trials does not allow a
comparative therapy assessment at present. The state of the data is inadequate for
applying local metronidazole dental gel as an alternative to mechanical
instrumentation in adult periodontitis.
AN - rayyan-563560999
AU - Knoll-Köhler, E.
IS - 6
KW - acylglycerol
drug derivative
Elyzol Dentalgel
metronidazole
sesame seed oil
adult
article
clinical trial
comparative study
controlled study
female
human
male
outcome assessment
peritonitis
reproducibility
LA - English
PY - 1999
SN - 0909-8836
SP - 415-421
ST - Metronidazole dental gel as an alternative to scaling and root planing in the
treatment of localized adult periodontitis. Is its efficacy proved?
TI - Metronidazole dental gel as an alternative to scaling and root planing in the
treatment of localized adult periodontitis. Is its efficacy proved?
VL - 107
ID - 14373
ER -
TY - JOUR
AB - BACKGROUND: Tumor necrosis factor (TNF)-α inhibitor has been shown to affect
the periodontal condition of patients with rheumatoid arthritis (RA). The aim of
the present study is to assess the effect of a fully humanized anti-TNF-α
monoclonal antibody, adalimumab (ADA), on the periodontal condition of patients
with RA and to compare serum protein profiles before and after ADA therapy.
METHODS: The study participants consisted of 20 patients with RA treated with ADA.
Clinical periodontal and rheumatologic parameters and serum cytokine levels were
evaluated at baseline and 3 months later. Serum protein spot volume was examined
with two-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis.
Proteins with significant difference in abundance before and after ADA therapy were
found and identified using mass spectrometry and protein databases. RESULTS: The
patients showed a significant decrease in gingival index (P = 0.002), bleeding on
probing (P = 0.003), probing depth (P = 0.002), disease activity score including 28
joints using C-reactive protein (P <0.001), and serum levels of TNF-α (P <0.001)
and interleukin-6 (P <0.001) after ADA medication, although plaque levels were
comparable. Among a total of 495 protein spots obtained, nine spots were
significantly decreased in abundance at reassessment, corresponding to complement
factor H, phospholipase D, serum amyloid A, complement component 4, and α-1-acid
glycoprotein (P <0.01). CONCLUSION: These results suggest a beneficial effect of
ADA therapy on the periodontal condition of patients with RA, which might be
related to differences in serum protein profiles before and after ADA therapy.
AN - rayyan-563560417
AU - Kobayashi, T.
AU - Yokoyama, T.
AU - Ito, S.
AU - Kobayashi, D.
AU - Yamagata, A.
AU - Okada, M.
AU - Oofusa, K.
AU - Narita, I.
AU - Murasawa, A.
AU - Nakazono, K.
AU - Yoshie, H.
DO - 10.1902/jop.2014.140194
IS - 11
KW - adalimumab
antirheumatic agent
C reactive protein
complement component C4
complement factor H
complement factor H, human
cytokine
IL6 protein, human
interleukin 6
orosomucoid
phospholipase D
plasma protein
serum amyloid A
adult
aged
blood
comparative study
drug effect
female
follow up
human
male
middle aged
periodontal disease
periodontal pocket
periodontics
periodontitis
tooth plaque
LA - English
PY - 2014
SN - 1943-3670
SP - 1480-1488
ST - Periodontal and serum protein profiles in patients with rheumatoid arthritis
treated with tumor necrosis factor inhibitor adalimumab
TI - Periodontal and serum protein profiles in patients with rheumatoid arthritis
treated with tumor necrosis factor inhibitor adalimumab
VL - 85
ID - 13791
ER -
TY - JOUR
AB - Periodontitis is a chronic inflammatory and tissue-destructive disease. Since
the polymicrobiome in the oral cavity makes it difficult to treat, novel
therapeutic strategies are required. Hydrogels based on self-assembling peptides
(SAP) can be suitable candidates for periodontal therapy due to their
injectability, biocompatibility, cargo-loading capacity, and tunable
physicochemical and mechanical properties. In this study, two SAP hydrogels (P11-4
and P11-28/29) are examined for their intrinsic antimicrobial activity,
regenerative potential, and antibiotic delivery capacity. A significant
antibacterial effect of P11-28/29 hydrogels on the periodontal pathogen
Porphyromonas gingivalis and a less pronounced effect for P11-4 hydrogels is
demonstrated. The metabolic activity rates of human dental follicle stem cells
(DFSCs), which reflect cell viability and may thus indicate the regenerative
capacity, are similar on tissue culture polystyrene (TCPS) and on P11-4 hydrogels
after 14 days of culture. Noticeably, both SAP hydrogels strengthen the osteogenic
differentiation of DFSCs compared with TCPS. The incorporation of tetracycline,
ciprofloxacin, and doxycycline does not affect fibril formation of either SAP
hydrogel and results in favorable release kinetics up to 120 h. In summary, this
study reveals that P11-SAP hydrogels combine many favorable properties required to
make them applicable as prospective novel treatment strategy for periodontal
therapy.
AN - rayyan-563560183
AU - Koch, F.
AU - Ekat, K.
AU - Kilian, D.
AU - Hettich, T.
AU - Germershaus, O.
AU - Lang, H.
AU - Peters, K.
AU - Kreikemeyer, B.
DO - 10.1002/adhm.201900167
IS - 13
ciprofloxacin
doxycycline
monomer
peptide
polystyrene
tetracycline
article
bacterial growth
biocompatibility
bone development
cell regeneration
cell viability
colony forming unit
controlled study
dental follicle stem cell
drug effect
drug efficacy
drug mechanism
drug response
hemolysis
human
human cell
hydrogel
priority journal
stem cell
tissue culture
LA - English
PY - 2019
SN - ["2192-2659", "2192-2640"]
ST - A Versatile Biocompatible Antibiotic Delivery System Based on Self-Assembling
Peptides with Antimicrobial and Regenerative Potential
T2 - Adv. Healthc. Mater.
TI - A Versatile Biocompatible Antibiotic Delivery System Based on Self-Assembling
Peptides with Antimicrobial and Regenerative Potential
VL - 8
ID - 13557
ER -
TY - JOUR
AB - Background & Aim: To evaluate the adjunctive effect of a thermosensitive gel
formulation that contains 0.8% oligo hyaluronic acid (HA) combined with a
preservation system of octenidine HCl 0.625% and phenoxyethanol to scaling and root
planing (SRP) as compared with SRP alone in the treatment of residual pockets of
patients with stage 3 periodontitis. Methods: Thirty-four patients (21 males and 13
females) aged 29-78 years (51.3 ± 13.1) with stage 3 periodontitis were recruited
to participate in the present split-mouth study. None of the patients have been
previously treated for periodontitis. Plaque index (PI), probing depth (PD),
clinical attachment level (CAL) and bleeding on probing (BOP) were evaluated at
baseline and at 3- and 6-months posttreatment. Full-mouth SRP was performed in all
residual pockets ≥5 mm was performed. The gel was applied sub gingivally in the
test sites immediately after SRP (baseline) and 1 month later. The paired t-test
for two means was applied to test the statistical significance of the change from
baseline within each arm and determine the difference between groups. The level of
significance was set at 0.05 for all tests. Results: Mean PD reductions between
baseline and 3, 6 months were 1.98 mm and 2.79 mm for the test and 1.22 mm and 1.50
mm for the control group, respectively. Comparisons between the test and control
groups revealed that SRP + gel yielded statistically significantly higher PD
reductions compared to SRP alone (p < 0.0001). The test group presented
statistically significantly higher CAL gains and BOP reductions than the control
group (P < 0.0001). Conclusions: In residual pockets of stage 3 periodontitis
patients enrolled in maintenance, the local application of a thermosensitive gel
with an active HA ingredient and a preservation system of octenidine HCl 0.625% in
conjunction with SRP may additionally improve the clinical outcomes obtained with
SRP alone.
AN - rayyan-563559846
AU - Kolerman, R.
AU - Kahn, A.
AU - Ziv-On, H.
AU - Sculean, A.
AU - Gadoth, N.
AU - Hirsch, A.
DO - 10.1111/jcpe.13635
octenidine
adult
aged
bleeding on probing
clinical article
clinical outcome
clinical trial
conference abstract
controlled study
female
human
male
mouth
outcome assessment
periodontitis
prospective study
root planing
LA - English
PY - 2022
SN - 1600-051X
SP - 85-86
ST - A thermosensitive gel with an active hyaluronic acid ingredient that contains
an octenidine preservation system as an adjunct to scaling and root planing. A
TI - A thermosensitive gel with an active hyaluronic acid ingredient that contains
an octenidine preservation system as an adjunct to scaling and root planing. A
VL - 49
ID - 13220
ER -
TY - JOUR
AB - There are over four hundred different diseases occurring within the oral
cavity. These include, among others, mucositis, periodontitis, gingivitis, caries,
oral infections, which are usually treated topically. Active substances for topical
application in the oral cavity can be administered in the form of polymer films.
Polymer films can ensure the delivery of the active substances directly to the
affected area and a longer presence of the active substances in the oral cavity,
which increases the effectiveness of the treatment. The film is easy to apply and
the treatment can be discontinued immediately. The sustained-release systems can
reduce the frequency of drug administration, the doses, and side effects.
Infections can be caused by damage to the mucosa, and one of the benefits of buccal
films is to create a protective barrier on the surface of the damaged tissue, which
alleviates pain and increases the effectiveness of the treatment. Depending on the
active substance applied, the films may have antiseptic, antibacterial, antifungal,
anti-inflammatory, and analgesic effects. The paper describes the characteristics
of the site of application of polymer films, i.e.The oral mucosa and the saliva
environment. The advantages of a topical mucoadhesive drug form in comparison with
tablets, liquid, and semi-liquid formulations have been presented. Furthermore,
characteristics of an ideal film for topical application in the oral cavity have
been listed. Important factors which influence mucoadhesion are factors related to
the properties of polymers as well as physical and physiological factors.
Currently, there are six theories of mucoadhesion, such as adsorption theory,
diffusion theory, electrostatic theory, fracture theory, wettability theory, and
mechanical theory. The predominant methods of mucoadhesion testing are in vitro
methods, which consist in testing the forces needed to break the connection between
the mucoadhesive substance and the model membrane. The most important test methods
include tensile strength and percentage elongation, folding endurance. The polymers
used to make the films are of the first and second generation. The first group
includes anionic, cationic, and non-ionic polymers. The second generation includes
thiolated polymers, which can extend the residence time of the therapeutic
substance at the site of application and allow for its controlled release. The
methods of obtaining polymer films include the pouring method, hot-melt extrusion
method, semisolid casting production method, pressing method, solid dispersion
extrusion method, and methods using 3D printers. The film tests include the
following: The study of the gel mass, measurement of the film thickness, pH,
swelling index, moisture absorption, percentage of moisture, surface
characteristics, organoleptic testing, chemical stability testing, disintegration
time, drug content uniformity, and in vitro drug release.
AN - rayyan-563560056
AU - Kolodziejczyk, M. K.
AU - Klimczuk, M.
AU - Kolodziejska, J.
AU - Godlewska, M.
AU - Nachajski, M.
DO - 10.32383/farmpol/144974
IS - 10
KW - film
transmucosal drug delivery system
anion
cation
ion
polymer
adsorption
article
diffusion
dispersion
drug formulation
drug manufacture
drug release
drug screening
hot melt extrusion
in vitro study
liquid
mechanics
moisture
molecular stability
mouth cavity
mouth mucosa
mucoadhesion
organoleptic property
pH
physical parameters
physiological process
polymer production
retention time
salivary gland
surface analysis
tablet
tensile strength
thickness
LA - Polish
PY - 2021
SN - 0014-8261
SP - 622-633
ST - The formulation of mucoadhesive drug form for topical application in the oral
cavity-application, manufacturing technology, and testing methods
T2 - Formulacja mukoadhezyjnej postaci leku do miejscowego stosowania w jamie
ustnej aplikacja, wytwarzanie, metody badan
TI - The formulation of mucoadhesive drug form for topical application in the oral
cavity-application, manufacturing technology, and testing methods
VL - 77
ID - 13430
ER -
TY - JOUR
AB - Objective: Clinical improvement after periodontal tray application of
chlorine dioxide gel as an adjunct to scaling and root planing (SRP) in the
treatment of chronic periodontitis was studied for a period of 30 days. Materials
and methods: The tray fabrication was performed in a dental laboratory using the
Soft – Tray Sheets (Ultradent™), whereas scaling and root planing were done using
ultrasonic scaler and hand instruments. A total of 36 subjects with chronic
periodontitis were divided into 3 treatment groups: group I was treated with SRP
procedure combined with the prescription-tray application of chlorine dioxide gel;
group II was treated with SRP procedure with the application of chlorine dioxide
alone; and group III was treated with SRP procedure alone. Clinical parameters
examined were probing pocket depth (PPD) and papillary bleeding index (PBI);
measurements were taken at baseline (day0) and 30 days after SRP (day 30).
Comparison between treatment groups was tested statistically by Kruskal Wallis test
and Analysis of Variance (ANOVA). Results: There were significant differences in
the decrease of the average pocket depth and bleeding index in all the 3 treatment
groups (P = 0.001). Decreases in the pocket depth of groups I, II, and III were
50.9%, 47.9%, and 27.8%, respectively. Decreases in the papillary bleeding index of
groups I, II, and III were 88.2%, 68.9%, and 51.1%, respectively. Conclusion: The
application of chlorine dioxide gel using the custom tray after SRP in the
treatment of chronic periodontitis showed better clinical improvement in pocket
depth reduction and bleeding index compared to SRP alone.
AN - rayyan-563560122
AU - Komara, I.
AU - Alfa Winata, E.
AU - Susanto, A.
AU - Hendiani, I.
DO - 10.1016/j.sdentj.2019.08.006
IS - 4
KW - orthodontic device
periodontal probe
periodontal tray
periodontic device
tooth prosthesis
ultrasonic scaler
chlorine dioxide
gel
adult
aged
article
clinical article
controlled study
dental scaling
female
general pathological parameters
gingiva bleeding
human
male
plaque index
prescription
root planing
LA - English
PY - 2020
SN - 1013-9052
SP - 194-199
ST - Periodontal tray application of chlorine dioxide gel as an adjunct to scaling
and root planing in the treatment of chronic periodontitis
T2 - Saudi Dent. J.
TI - Periodontal tray application of chlorine dioxide gel as an adjunct to scaling
and root planing in the treatment of chronic periodontitis
VL - 32
ID - 13496
ER -
TY - JOUR
AB - Lactoferrin (Lf) is a member of the transferrin family of iron-binding anti-
bacterial proteins, present in most exocrine secretions, such as saliva, and plays
an important role in mucosal defense. In this study, we identified small Lf
peptides with Con A low-affinity in the parotid saliva of chronic periodontitis
patients by Con A two-dimensional immunoelectrophoresis, Con A affinity
chromatography and Western blotting using anti-human Lf polyclonal Ab. N-terminal
amino acid sequencing of the four Con A low-affinity Lf peptides confirmed them to
be fragments of intact Lf. The detection ratio of the proteinase 3 (PR3)-like
activity was elevated in the parotid saliva of periodontitis patients and was
associated with the severity of clinical symptoms. PR3 protein was also detected in
the parotid saliva of periodontitis patients, and PR3, but not human leukocyte
elastase and cathepsin G, degraded intact Lf. Con A low-affinity saliva Lf peptides
showed no anti-bacterial activity against Escherichia coli, and had a reduced iron-
chelating capacity. Con A low-affinity saliva Lf peptides, PR3-treated Lf
preparation and two of four synthetic polypeptides induced the production of
interleukin IL-6, monocyte chemoattractant protein-1 and IL-8, and the activation
of NF-κB in human oral epithelial HSC-2 cells. Furthermore, concentrations of the
Lf peptides in the parotid saliva of periodontitis patients were increased with a
correlation to the severity of clinical symptoms. These results suggest that Lf in
the parotid saliva of periodontitis patients was degraded into small peptides by
the PR3-like activity with the capability to induce inflammatory mediators. © 2006
Elsevier Ltd. All rights reserved.
AN - rayyan-563560750
AU - Komine, K. i
AU - Kuroishi, T.
AU - Ozawa, A.
AU - Komine, Y.
AU - Minami, T.
AU - Shimauchi, H.
AU - Sugawara, S.
DO - 10.1016/j.molimm.2006.09.003
IS - 7
KW - cathepsin G
concanavalin A
elastase
interleukin 6
interleukin 8
lactoferrin
myeloblastin
polyclonal antibody
polypeptide
adult
aged
article
controlled study
crossed immunoelectrophoresis
cytokine production
disease severity
enzyme activity
epithelium cell
Escherichia coli
human
human cell
iron chelation
parotid gland
periodontitis
priority journal
protein analysis
protein degradation
saliva analysis
Western blotting
LA - English
PY - 2007
SN - 0161-5890
SP - 1498-1508
ST - Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis
patients
T2 - Mol. Immunol.
TI - Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis
patients
VL - 44
ID - 14124
ER -
TY - JOUR
AB - Lactoferrin (Lf) is a member of the transferrin family of iron-binding anti-
bacterial proteins, present in most exocrine secretions, such as saliva, and plays
an important role in mucosal defense. In this study, we identified small Lf
peptides with Con A low-affinity in the parotid saliva of chronic periodontitis
patients by Con A two-dimensional immunoelectrophoresis, Con A affinity
chromatography and Western blotting using anti-human Lf polyclonal Ab. N-terminal
amino acid sequencing of the four Con A low-affinity Lf peptides confirmed them to
be fragments of intact Lf. The detection ratio of the proteinase 3 (PR3)-like
activity was elevated in the parotid saliva of periodontitis patients and was
associated with the severity of clinical symptoms. PR3 protein was also detected in
the parotid saliva of periodontitis patients, and PR3, but not human leukocyte
elastase and cathepsin G, degraded intact Lf. Con A low-affinity saliva Lf peptides
showed no anti-bacterial activity against Escherichia coli, and had a reduced iron-
chelating capacity. Con A low-affinity saliva Lf peptides, PR3-treated Lf
preparation and two of four synthetic polypeptides induced the production of
interleukin IL-6, monocyte chemoattractant protein-1 and IL-8, and the activation
of NF-kappaB in human oral epithelial HSC-2 cells. Furthermore, concentrations of
the Lf peptides in the parotid saliva of periodontitis patients were increased with
a correlation to the severity of clinical symptoms. These results suggest that Lf
in the parotid saliva of periodontitis patients was degraded into small peptides by
the PR3-like activity with the capability to induce inflammatory mediators.
AN - rayyan-563561415
AU - Komine, K.
AU - Kuroishi, T.
AU - Ozawa, A.
AU - Komine, Y.
AU - Minami, T.
AU - Shimauchi, H.
AU - Sugawara, S.
DO - 10.1016/j.molimm.2006.09.003
IS - 7
J2 - Mol Immunol
KW - Amino Acid Sequence
Chemokines/metabolism
Concanavalin A/chemistry
Cytokines/metabolism
Electrophoresis, Gel, Two-Dimensional
Humans
Lactoferrin/chemistry/*metabolism
Molecular Sequence Data
Mouth Mucosa/drug effects/immunology
Myeloblastin/*metabolism
NF-kappa B/metabolism
Parotid Gland/*metabolism
Peptide Fragments/*analysis/pharmacology
Periodontitis/diagnosis/*metabolism
Saliva/*chemistry
LA - eng
N1 - Division of Oral Immunology, Department of Oral Biology, Tohoku University
Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
PY - 2007
SN - 0161-5890 (Print)
SP - 1498-508
ST - Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis
patients
T2 - Molecular immunology
TI - Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis
patients
VL - 44
Y2 - 3
ID - 14789
ER -
TY - JOUR
AB - Xerostomia, commonly known as dry mouth, is a widespread oral health
malfunction characterized by decreased salivary flow. This condition results in
discomfort, impaired speech and mastication, dysphagia, heightened susceptibility
to oral infections, and ultimately, a diminished oral health-related quality of
life. The etiology of xerostomia is multifaceted, with primary causes encompassing
the use of xerostomic medications, radiation therapy to the head and neck, and
systemic diseases such as Sjögren’s syndrome. Consequently, there is a growing
interest in devising management strategies to address this oral health issue, which
presents significant challenges due to the intricate nature of saliva.
Historically, natural products have served medicinal purposes, and in contemporary
pharmaceutical research and development, they continue to play a crucial role,
including the treatment of xerostomia. In this context, the present review aims to
provide an overview of the current state of knowledge regarding natural compounds
and extracts for xerostomia treatment, paving the way for developing novel
therapeutic strategies for this common oral health issue.
AN - rayyan-563559690
AU - Kontogiannopoulos, K. N.
AU - Kapourani, A.
AU - Gkougkourelas, I.
AU - Anagnostaki, M. E.
AU - Tsalikis, L.
AU - Assimopoulou, A. N.
AU - Barmpalexis, P.
DO - 10.3390/ph16081136
IS - 8
KW - alkaloid
alpha tocopherol
amylase
antitussive agent
apigenin
artemisinin
carnosine
chorionic gonadotropin
coconut oil
essential oil
estrogen receptor
estrogen receptor alpha
flavonoid
glucosylceramide
hydrogel
lycopene
nanofiber
natural product
oxybutynin
paclitaxel
plant extract
polyphenol
prostaglandin E2
saliva substitute
testosterone
abdominal pain
Aloe vera
Asteraceae
biofilm
breast cancer
burning mouth syndrome
burning sensation
cell proliferation
cellular immunity
constipation
diet supplementation
disease free survival
drug efficacy
drug research
dyspepsia
dysphagia
electrospinning
glossopharyngeal nerve
glucose blood level
head and neck cancer
headache
health
Hibiscus sabdariffa
human
hydrocolloid
hyperglycemia
hypertension
hyposalivation
intensive care unit
malaria
malocclusion
mastication
medicinal plant
mouth discomfort
mouth hygiene
nonhuman
oral mucositis
osteolysis
osteoporosis
overall survival
oxidative stress
pain severity
palliative therapy
parotid gland
periodontitis
Plantago ovata
prevalence
protein expression
quality of life
questionnaire
regulatory T lymphocyte
review
risk factor
saliva
salivation
sarcoidosis
Schirmer test
scoring system
sex difference
Th17 cell
thorax pain
tooth plaque
urinary frequency
vertigo
visual analog scale
xerostomia
LA - English
PY - 2023
SN - 1424-8247
ST - A Review of the Role of Natural Products as Treatment Approaches for
Xerostomia
TI - A Review of the Role of Natural Products as Treatment Approaches for
Xerostomia
VL - 16
ID - 13064
ER -
TY - CHAP
AN - rayyan-563561853
AU - Chatzistavrou, X.
AU - Paraskevopoulos, K. M.
AU - Koidis, P.
DO - 10.1007/978-3-319-32101-1_117
PY - 2018
SP - 3489-3503
ST - Bioactive ceramic porcelain/glass for dental application
T2 - Handbook of Sol-Gel Science and Technology: Processing, Characterization and
Applications
TI - Bioactive ceramic porcelain/glass for dental application
85054369766&doi=10.1007%2f978-3-319-32101-
1_117&partnerID=40&md5=4b9e33d0af4ed9c4b4bd07b8719386ec
ID - 15227
ER -
TY - JOUR
AB - A promising way to control peri-implantitits, a bacteria-associated disease
causing bone loss around dental implants, is the local administration of
antimicrobial drugs or growth factors at the implant site. Recombinant human bone
morphogenetic protein-2 (rh-BMP-2) can effectively promote bone regeneration and
osseointegration [1]. Mesoporous materials constitute promising carriers for the
delivery of various cargos and could be implemented in the local administration of
rh-BMP-2. The aim of the present study was to evaluate the hemolytic properties of
novel, rhBMP-2-loaded mesoporous silica and their effect on the viability of human
periodontal ligament cells (hPDLCs). Mesoporous silica was synthesized via sol-gel
reaction, following the co-operative self-assembly route in acidic media.
Tetraethyl orthosilicate (TEOS) was used as the silica source and Pluronic P123 as
the structure directing agent. The loading of rh- BMP-2 was obtained after
immersion in PBS, stirring and subsequent centrifugation. The effect of rh-BMP-2-
loaded mesoporous silica on cell viability was evaluated through indirect MTT test.
The hemolytic activity was tested at various concentrations (12.5-500mg/ml) in
contact with human red blood cells. At all concentrations low or no hemolytic
activity was recorded. A higher hPDLCs proliferation rate was recorded after
loading with rhBMP-2. These findings suggest the potential use of the synthesized
mesoporous silica as biocompatible and effective carrier for the local delivery of
rhBMP-2 in peri-implantitis treatment strategies. Acknowledgments: This work is
supported by European Union's Horizon 2020 research and innovation programme under
grant agreement No 953128, project: Smart, Multifunctional Dental Implants: A
solution for peri-implantitis and bone loss.
AN - rayyan-563559875
AU - Gkiliopoulos, D.
AU - Tsamesidis, I.
AU - Triantafyllidis, K.
DO - 10.1089/ten.tea.2022.29025.abstracts
endogenous compound
poloxamer
silicon dioxide
tetraethoxysilane
adverse device effect
biocompatibility
cell proliferation
cell viability
centrifugation
conference abstract
controlled study
erythrocyte
European Union
hemolysis
human
immersion
osteolysis
periimplantitis
sol-gel
tooth implant
LA - English
PY - 2022
SN - 1937-335X
SP - S606
ST - BIOCOMPATIBILITY OF RH-BMP-2-LOADED MESOPOROUS SILICA WITH PERIODONTAL
LIGAMENT CELLS
T2 - Tissue Eng. Part A
TI - BIOCOMPATIBILITY OF RH-BMP-2-LOADED MESOPOROUS SILICA WITH PERIODONTAL
LIGAMENT CELLS
VL - 28
ID - 13249
ER -
TY - JOUR
AB - Silica-based mesoporous nanocarriers (MSNs) have received widespread interest
due to their ordered structure and high specific surface area, which allow fine
control of drug loading and release kinetics1,2. Ca-containing MSNs are promising
bioactive mesoporous drug carriers, as they can release Ca and Si ions that
stimulate osteogenic differentiation of stem cells3. Moxifloxacin is an antibiotic
with broad antimicrobial activity against aerobic and anaerobic bacteria, which
could be applied locally for bacterial elimination in cases of periodontal or peri-
implant desease4. The aim of this study was the evaluation of different Ca-doped
MSNs in terms of moxifloxacin loading/release profiles, biocompatibility and
hemolytic activity. The synthesis of MSNs was performed by the sol-gel method5.
Their drug loading and release profiles were assessed with High Performance Liquid
Chromatography (HPLC) and their cell viability with the MTT assay on human
periodontal ligament cells (hPDLCs). Their hemolytic activity was evaluated in
contact with human red blood cells at various concentrations. The loading capacity
of Ca-doped MSNs (21-38%) was higher than pure silica (15%), revealing the
beneficial effect of Ca. Prolonged release of moxifloxacin was apparent even after
eight days. They presented limited hemolysis and no cytotoxicity, while promoting
the mitochondrial activity and proliferation of hPDLCs. This research is co-
financed by Greece and the European Union (European Social Fund- ESF) through the
Operational Programme ''Human Resources Development, Education and Lifelong
Learning'' in the context of the project ''Strengthening Human Resources Research
Potential via Doctorate Research'' (MIS-5000432), implemented by the State
Scholarships Foundation (IK!).
AN - rayyan-563559874
AU - Pouroutzidou, G.
AU - Lazaridou, M.
AU - Christodoulou, E.
AU - Tsamesidis, I.
AU - Bikiaris, D.
KW - calcium
moxifloxacin
nanoparticle
silicon dioxide
biocompatibility
cell proliferation
cell viability
conference abstract
controlled study
cytotoxicity
education
erythrocyte
European Union
Greece
hemolysis
human
human cell
human tissue
lifelong learning
mitochondrion
MTT assay
sol-gel
surface area
synthesis
LA - English
PY - 2022
SN - 1937-335X
SP - S396
ST - CALCIUM CONTAINING MESOPOROUS NANOPARTICLES FOR DRUG DELIVERY APPLICATIONS
TI - CALCIUM CONTAINING MESOPOROUS NANOPARTICLES FOR DRUG DELIVERY APPLICATIONS
VL - 28
ID - 13248
ER -
TY - JOUR
AB - Growth factors are soluble secreted proteins capable of affecting a variety
of cellular processes important for tissue regeneration. Consequently, the self-
healing capacity of patients can be augmented by artificially enhancing one or more
processes important for healing through the application of growth factors. However,
their application in clinics remains limited due to lack of robust delivery systems
and biomaterial carriers. Interestingly, all clinically approved therapies
involving growth factors utilize some sort of a biomaterial carrier for growth
factor delivery. This suggests that biomaterial delivery systems are extremely
important for successful usage of growth factors in regenerative medicine. This
review outlines the role of growth factors in tissue regeneration, and their
application in both pre-clinical animal models of regeneration and clinical trials
is discussed. Additionally, current status of biomaterial substrates and
sophisticated delivery systems such as nanoparticles for delivery of exogenous
growth factors and peptides in humans are reviewed. Finally, issues and possible
future research directions for growth factor therapy in regenerative medicine are
discussed. © 2012 Springer International Publishing AG. All rights reserved.
AN - rayyan-563560548
AU - Koria, P.
DO - 10.2165/11631850-000000000-00000
IS - 3
KW - agarose
alginic acid
augment
becaplermin
brain derived neurotrophic factor
calcium phosphate
carrageenan
chitosan
collagen sponge
elastin
fibrin
gelatin
gem 21s
granulocyte colony stimulating factor receptor
growth differentiation factor 5
growth factor
hyaluronic acid
infuse
keratinocyte growth factor
op 1
palifermin
platelet derived growth factor BB
polyglycolic acid
polylactic acid
polylysine
scatter factor
starch
stromal cell derived factor 1alpha
unclassified drug
unindexed drug
vasculotropin
apoptosis
bone regeneration
burn
cell metabolism
cell migration
cervical spine injury
chemotaxis
critical limb ischemia
diabetic foot
disease model
fracture
heart infarction
human
hydrogel
ligament injury
liver cirrhosis
lung injury
molecular mechanics
mucosa inflammation
muscle disease
nonhuman
periodontal disease
priority journal
protein function
review
signal transduction
silk
skin injury
spinal cord injury
tissue growth
tissue regeneration
ulcer
wound healing
kepivance
regranex
LA - English
PY - 2012
SN - ["1173-8804", "1179-190X"]
SP - 163-175
ST - Delivery of growth factors for tissue regeneration and wound healing
T2 - BioDrugs
TI - Delivery of growth factors for tissue regeneration and wound healing
VL - 26
ID - 13922
ER -
TY - JOUR
AB - BACKGROUND: Periodontitis is characterized by extensive destruction of the
gingival tissues and associated supporting structures of the teeth. Although the
pathogenesis of the various forms of this disease is not completely understood,
host-derived proteases are believed to have an important role. In this study, we
analyzed human tissue samples from chronic adult periodontitis patients to assess
the levels of specific proteases and determine the effect of pH and tetracyclines
on their activity. METHODS: Gingival tissue samples were obtained from patients
with chronic adult periodontitis (probing depths ranged from 5 to 9 mm) and
periodontally healthy controls. Tissue extracts were prepared and analyzed for
protease activity by zymography and Western blotting. RESULTS: Maximal protease
activity from clinically normal and diseased tissues was observed at pH 8. Latent
matrix metalloproteinase (MMP)-9 and MMP-2 were expressed in all samples examined,
while active MMP-2 was detected only in tissues obtained from patients with
clinical disease. The MMP activities were differentially inhibited by derivatives
of tetracycline. At pH 6, a protease with a mass of approximately 40 kDa was
observed in diseased samples. The enzymatic activity was inhibited by
phenylmethylsulfonyl fluoride, suggesting it is a serine protease. CONCLUSIONS: The
results of the current study substantiate the proposed role of host-derived
proteases in the pathogenesis of chronic adult periodontitis. Specifically, they
indicate that activated MMP-2 and a 40 kDa serine protease are involved in tissue
destruction associated with this form of periodontal disease and also suggest that
tissue pH influences protease activity in situ.
AN - rayyan-563560993
AU - Korostoff, J. M.
AU - Wang, J. F.
AU - Sarment, D. P.
AU - Stewart, J. C.
AU - Feldman, R. S.
AU - Billings, P. C.
IS - 3
benzylsulfonyl fluoride
enzyme inhibitor
gelatinase A
serine proteinase
adult
article
chronic disease
cohort analysis
drug antagonism
drug effect
enzymology
gingiva
human
periodontitis
pH
Western blotting
LA - English
PY - 2000
SN - 0022-3492
SP - 353-360
ST - Analysis of in situ protease activity in chronic adult periodontitis
patients: expression of activated MMP-2 and a 40 kDa serine protease
TI - Analysis of in situ protease activity in chronic adult periodontitis
patients: expression of activated MMP-2 and a 40 kDa serine protease
VL - 71
ID - 14367
ER -
TY - JOUR
AN - rayyan-563562574
AU - Koshy, G.
AU - Corbet, E. F.
AU - Ishikawa, I.
DO - 10.1111/j.1600-0757.2004.03678.x
PY - 2004
SN - ["0906-6713", "1600-0757"]
SP - 166-178
ST - A full-mouth disinfection approach to nonsurgical periodontal therapy -
prevention of reinfection from bacterial reservoirs
T2 - PERIODONTOLOGY 2000
TI - A full-mouth disinfection approach to nonsurgical periodontal therapy -
prevention of reinfection from bacterial reservoirs
VL - 36
ID - 15948
ER -
TY - JOUR
AB - The aim of endodontic therapy is to use various antimicrobial medications for
proper cleaning and shaping to create an environment free of microorganisms by
eradicating as many as possible from the root canal space. Even although it is a
gold standard irrigant, sodium hypochlorite (NaOCl) is known for its cytotoxic
effects on vital periapical tissues, making its higher concentrations inappropriate
for use in conditions such as wide, underdeveloped, or damaged apices and in cases
of perforations. Consequently, if it is ascertained that a gel form of sodium
hypochlorite has equivalent antibacterial activity to the aqueous solution form, it
could be employed in such situations. The aim of this study was the microbiologic
evaluation of 5.25% sodium hypochlorite gel and aqueous solution as root canal
disinfectants in multirooted teeth with primary endodontic lesions. Following
ethical approval and CTRI registration, 42 patients who gave their consent and had
multirooted teeth with pulpal necrosis and asymptomatic apical periodontitis were
considered for the study. Following the opening of the access, pre-endodontic build
up in case of class-II cavities and working length determination, a pre-operative
sample (S1), which was regarded as the pre-operative microbial load of that canal,
was acquired from the largest canal using a sterile paper point while maintaining
strict isolation and disinfection. The computer randomization approach was used to
divide the teeth into two groups at random just before beginning of chemo-
mechanical preparation: Group A (n = 21)—canal disinfection with 5.25% sodium
hypochlorite gel; Group B (n = 21)—canal disinfection with 5.25% sodium
hypochlorite aqueous solution. Following the canal disinfection, a post-operative
(S2) sample which was regarded as the postoperative microbial load of that canal
was collected from the same canal using a sterile paper point. The Colony-Forming
Units (CFUs) for the S1 and S2 samples were determined after 48 h aerobic
incubation on Brain Heart Infusion (BHI) agar plates. The patients and the
microbiologist were blinded throughout the procedure. Using SPSS 20.0 software
(USA), the Shapiro–Wilk test and the Lilliefors Significance Correction were used
for normality, followed by the Mann–Whitney U test which was used to compare the
CFU difference (×105) between the two groups. A p value of <0.05 was perceived as
statistically significant. The mean colony-forming units count difference between
the 5.25% sodium hypochlorite gel and aqueous solution groups did not differ in a
manner that was statistically significant (p = 0.744). In multirooted teeth with
primary endodontic lesions, the 5.25% sodium hypochlorite gel and the aqueous
solution demonstrated comparable antimicrobial effectiveness when implemented as
root canal disinfectants.
AN - rayyan-563559717
AU - Kotecha, N.
AU - Shah, N. C.
AU - Doshi, R. J.
AU - Kishan, K. V.
AU - Luke, A. M.
AU - Shetty, K. P.
AU - Mustafa, M.
AU - Pawar, A. M.
DO - 10.3390/jfb14050240
IS - 5
KW - CTRI/2022/02/040647
agar
gel
hypochlorite sodium
adult
aqueous solution
article
clinical article
colony forming unit
controlled study
disinfection
female
human
isolation
male
microbiology
nonhuman
pathogen load
periodontitis
rank sum test
tooth pulp disease
tooth root canal
LA - English
PY - 2023
SN - 2079-4983
ST - Microbiological Effectiveness of Sodium Hypochlorite Gel and Aqueous Solution
When Implemented for Root Canal Disinfection in Multirooted Teeth: A Randomized
Clinical Study
TI - Microbiological Effectiveness of Sodium Hypochlorite Gel and Aqueous Solution
When Implemented for Root Canal Disinfection in Multirooted Teeth: A Randomized
Clinical Study
VL - 14
ID - 13091
ER -
TY - JOUR
AB - Context: Platelet concentrates are commonly used to promote periodontal soft-
and hard-tissue regeneration. Recently, their antimicrobial efficacy is also
explored. Various platelet concentrates have evolved which differ in the
centrifugation protocols. Porphyromonas gingivalis (Pg) and Aggregatibacter
actinomycetemcomitans (Aa) have been found to have an important role in periodontal
pathology. Aims: In this study, PRP, PRF, and I-PRF are compared for their
antibacterial effect against Pg and Aa. Materials and Methods: Blood samples were
obtained from ten systemically and periodontally healthy individuals. Platelet
concentrates were prepared using standardized centrifugation protocol.
Antimicrobial activity was examined on standard strains of Pg and Aa using well
diffusion method. Statistical Analysis Used: Means for the width of zones of
inhibition were calculated along with standard deviations, and the comparison was
made using Wilcoxon signed-rank test. Results: In case of Pg, I-PRF had the widest
zone of inhibition which was significantly wider as compared to PRF. Furthermore,
PRP had significantly wider zone of inhibition against PRF. In case of Aa, PRP had
wider zone of inhibition which was significantly wider as compared to that of PRF
and I-PRF. Conclusions: All the three platelet concentrates PRP, PRF, and I-PRF
have antibacterial activity, but PRP and I-PRF are more active as compared to PRF.
I-PRF being autologous and easy to prepare can be a very useful adjunct to the
surgical therapy in bringing down the bacterial count helping in wound healing and
regeneration.
AN - rayyan-563562422
AU - Kour, P.
AU - Pudakalkatti, P. S.
AU - Vas, A. M.
AU - Das, S.
DO - 10.4103/ccd.ccd_367_18
PY - 2018
SN - ["0976-237X", "0976-2361"]
SP - S325-S330
ST - Comparative Evaluation of Antimicrobial Efficacy of Platelet-rich Plasma,
Platelet-rich Fibrin, and Injectable Platelet-rich Fibrin on the Standard Strains
of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans
T2 - CONTEMPORARY CLINICAL DENTISTRY
TI - Comparative Evaluation of Antimicrobial Efficacy of Platelet-rich Plasma,
Platelet-rich Fibrin, and Injectable Platelet-rich Fibrin on the Standard Strains
of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans
VL - 9
Y2 - 9
ID - 15796
ER -
TY - JOUR
AB - Introduction: Inflammatory periodontal diseases take one of the first places
among dental diseases; they are prevalent in various age groups and tend to grow
steadily. The highest morbidity rate is found at the age from 15 to 44, that is 64-
98% of the population. For the rational pathogenetic therapy, multiagent
medications affecting different parts of the pathological process in a multiple way
should be developed. Materials and Methods: In the work, marketing and economic
research methods are used to ground social and medical practicability of developing
new dental products for local treatment. Results and Discussions: With reference to
the analysis of the Ukrainian market, it was found out that a dominant position in
the range of dental gels, presented at the national pharmaceutical market is held
by imported preparations. Methodological approaches to developing semisolid dosage
form for treating inflammatory periodontal and oral mucosa diseases were
summarized. Conclusions: Methodological approaches to developing medicine in gel
dosage form for treating inflammatory periodontal and oral mucosa diseases were
developed. With reference to the proposed methodology for developing gel for
applying in dental practice, we theoretically and experimentally grounded the
structure and rational technology of new combination preparations “Aloe-Dental” and
“Dentatrigin” in the form of gels.
AN - rayyan-563560322
AU - Kovalenko, S. M.
AU - Khokhlenkova, N. V.
AU - Azarenko, J. M.
IS - 1
KW - acrylic acid derivative
chlorhexidine
metronidazole
non prescription drug
article
bioavailability
circulation
dental practice
drug industry
drug manufacture
economics
flow kinetics
gel
human
inflammation
marketing
methodology
mouth mucosa
permeability
reproduction
solubility
tissue regeneration
tooth disease
LA - English
PY - 2017
SN - ["1998-409X", "0973-8398"]
SP - S129-S135
ST - Methodological aspects of development of gels for treating inflammatory
dental diseases
T2 - Asian J. Pharm.
TI - Methodological aspects of development of gels for treating inflammatory
dental diseases
VL - 11
ID - 13696
ER -
TY - JOUR
AB - Purpose: Local drug delivery systems are preferred over systemic antibiotic
therapy in indicated cases to avoid unnecessary large doses of drug, development of
antibiotic resistance etc. The search for the more suitable novel vehicle for the
local drug delivery that can render controlled release of drug at periodontally
infected sites are widely researched. i-PRF being autologous and injectable could
be a suitable vehicle for local delivery of drugs. This study aims to evaluate the
possibility of using i-PRF as a controlled release drug vehicle in periodontal
therapy. Methods: i-PRF obtained from centrifugation of 10 ml of blood collected
from volunteers are mixed with known concentration of chlorhexidine drug and
allowed to become a gel. The drug loaded gel is dispensed in artificial saliva and
allowed to degrade. At specific time intervals (1 hr, 3 hr, 5 hr, 7 hr, 3d, 5d, 7d,
9d, 14d) aliquote of the 200 microliter were collected from each sample and
subjected for spectrophotometric analysis. Results: The spectrophotometric results
show that the drug was detected in all the samples obtained from the 1 hr to the
14th day. Final concentration in the eluted samples seem to be gradually reducing
from the 1 hr to the 7 th hour and a steep downward pattern in the concentration
was absorbed from the 3 rd day until 14th day. Conclusion: The controlled
chlorhexidine release profile of the i-PRF shows its a potential and suitable
vehicle for LDD system in periodontal therapy. Additionally, properties like the
syringeability, in-situ gel formation, and autologous fibrin nature may facilitate
its direct delivery into the periodontal pocket, getting moulded to the pocket
shape with attachment to the soft and hard tissue thereby ensuring the retention of
the drug loaded i-PRF in the confined pocket environment.
AN - rayyan-563559775
AU - Kowshihan, P.
AU - Murugan, T.
AU - Ganapathy, D.
DO - 10.47750/jptcp.2023.30.12.022
IS - 12
KW - Jasco V-730
chlorhexidine
drug vehicle
adult
article
controlled study
drug release
human
human experiment
in vitro study
periodontal therapy
periodontium
LA - English
PY - 2023
SN - ["2561-8741", "1710-6222"]
SP - e192-e200
ST - Use of injectable platelet rich fibrin (IPRF) as LDD vehicle containing
chlorhexidine in periodontal Therapy – In vitro study
TI - Use of injectable platelet rich fibrin (IPRF) as LDD vehicle containing
chlorhexidine in periodontal Therapy – In vitro study
VL - 30
ID - 13149
ER -
TY - JOUR
AB - Porphyromonas gingivalis is a major etiologic agent of periodontitis, a
chronic inflammatory disease that ultimately results in the loss of the supporting
tissues of the teeth. Previous work has demonstrated the usefulness of avirulent
Salmonella enterica serovar Typhimurium strains as antigen delivery systems for
protective antigens of pathogens that colonize or cross mucosal surfaces. In this
study, we constructed and characterized a recombinant S. enterica serovar
Typhimurium avirulent vaccine strain which expresses hemagglutinin A and carries no
antibiotic resistance markers. HagA, a major virulence-associated surface protein,
is a potentially useful immunogen that contains an antigenic epitope which, in
humans, elicits an immune response that is protective against subsequent
colonization by P. gingivalis. The hagA gene, including its promoter, was cloned
into a balanced-lethal Salmonella vector and transferred to the vaccine strain.
Heterologous expression of HagA was demonstrated in both Escherichia coli JM109 and
S. enterica serovar Typhimurium vaccine strain X4072. The HagA epitope was present
in its native configuration as determined by immunochemistry and immunoelectron
microscopy. Purified recombinant HagA was recognized by sera from mice immunized
with the S. enterica serovar Typhimurium vaccine strain. The HagA-specific antigen
of the vaccine was also found to be recognized by serum from a periodontal patient.
This vaccine strain, which expresses the functional hemagglutinin protein, induces
a humoral immune response against HagA and may be useful for developing a
protective vaccine against periodontal diseases associated with P. gingivalis.
AN - rayyan-563560995
AU - Kozarov, E.
AU - Miyashita, N.
AU - Burks, J.
AU - Cerveny, K.
AU - Brown, T. A.
AU - McArthur, W. P.
AU - Progulske-Fox, A.
DO - 10.1128/IAI.68.2.732-739.2000
IS - 2
antigen
epitope
hemagglutinin
membrane protein
vaccine
animal experiment
article
controlled study
gene
human
humoral immunity
immunoblotting
immunochemistry
immunoelectron microscopy
immunogenicity
mouse
nonhuman
periodontitis
priority journal
Salmonella enterica
LA - English
PY - 2000
SN - 0019-9567
SP - 732-739
ST - Expression and immunogenicity of hemagglutinin a from Porphyromonas
gingivalis in an avirulent Salmonella enterica serovar typhimurium vaccine strain
T2 - Infect. Immun.
TI - Expression and immunogenicity of hemagglutinin a from Porphyromonas
gingivalis in an avirulent Salmonella enterica serovar typhimurium vaccine strain
VL - 68
ID - 14369
ER -
TY - JOUR
AB - The near future of drug delivery system would lie in the search of a
versatile and innocuous material, based mostly on the natural resources. The
tamarind seed xyloglucan (XG) is a natural neutral hemicellulose and a hydrophilic
polysaccharide consisting of a main chain of glucan backbone with xylose and
galactose side chains. XG is endowed with idiosyncratic mucoadhesive and in situ
gelling properties which rated XG as an attractive, functional polymer for numerous
drug delivery applications. In milieu of this, the present review is designed to
underline the plausible potential of XG or XG-based systems in drug delivery. The
feasibility of surface-tailoring, the flexibility of chemical-modification, and the
possibility as ligand-conjugations grant XG an extraordinary consideration in the
scientific territory. The authors are hopeful that the versatility of XG would meet
the expectations of regulatory authorities and the XG-based products will serve the
therapeutic needs of the community in the future, if sufficiently investigated and
promising outcomes are obtained in human subjects.
AN - rayyan-563560283
AU - Kulkarni, A. D.
AU - Joshi, A. A.
AU - Patil, C. L.
AU - Amale, P. D.
AU - Patel, H. M.
AU - Surana, S. J.
AU - Belgamwar, V. S.
AU - Chaudhari, K. S.
AU - Pardeshi, C. V.
DO - 10.1016/j.ijbiomac.2017.06.088
KW - alcohol derivative
carbohydrate
glucan
ibuprofen
indometacin
iodine
ketoprofen
ketorolac trometamol
lidocaine
mitomycin
montelukast
paracetamol
polyphenol
polysaccharide
rizatriptan
thiol derivative
tropicamide
unclassified drug
xyloglucan
zolmitriptan
amination
carbohydrate analysis
complex formation
extraction
feasibility study
gelation
history
human
intrapulmonary drug administration
isolation procedure
ligand binding
macromolecule
coating (procedure)
methylation
molecular weight
mucoadhesion
nasal drug delivery system
nonhuman
periodontal drug administration
polysaccharide structure
review
solubility
surface property
viscosity
tropicacyl
LA - English
PY - 2017
SN - ["1879-0003", "0141-8130"]
SP - 799-812
ST - Xyloglucan: A functional biomacromolecule for drug delivery applications
TI - Xyloglucan: A functional biomacromolecule for drug delivery applications
VL - 104
ID - 13657
ER -
TY - JOUR
AB - Periodontitis is a microbiological condition that affects the tissues
supporting the teeth. The fundamental to effective periodontal therapy is choosing
the suitable antimicrobial and anti-inflammatory agent, together with the proper
route of drug administration and delivery system. Intra-periodontal pocket approach
with nano drug-delivery systems (NDDS) such as polymeric nanoparticles, gold
nanoparticles, silica nanoparticles, magnetic nanoparticles, liposomes,
polymersomes, exosomes, nano micelles, niosome, solid lipid nanoparticles, nano
lipid carriers, nanocomposites, nanogels, nanofibers, scaffolds, dendrimers,
quantum dots, etc., will be appropriate route of drug administration and delivery
system. This NDDS delivers the drugs at the site of infection to inhibit growth and
promote tissue regeneration. The present review focused on providing comprehensive
information on the NDDS for periodontitis, which enhanced therapeutic outcomes via
intra-periodontal pocket delivery. Plain language summary Periodontitis is a
problem that can make your teeth fall out. It happens when the tissues that hold
your teeth start to break down. Scientists have found a way to help treat it by
using tiny things called ‘nano drug-delivery systems' or NDDS. These NDDS carry
medicine to the infected area and stop the germs from growing. They can also help
the tissue around your teeth to heal. Some examples of NDDS are liposomes,
polymersomes, exosomes, nanomicelles, and more. Regular treatment with antibiotics
may not work as well as NDDS. Using NDDS can make a big difference in how well your
teeth and gums heal. In the future, scientists hope to use NDDS to prevent the
problem from coming back. This new way of treating periodontitis could be a big
help for people with this problem.
AN - rayyan-563559746
AU - Kumaar, N. R.
AU - Nair, S. C.
DO - 10.4155/tde-2023-0001
IS - 3
KW - 5' nucleotidase
arginylglycylaspartic acid
chlorhexidine
curcumin
dendrimer
gold nanoparticle
interleukin 1
interleukin 10
interleukin 6
liposome
macrogol
molecular scaffold
nanocomposite
nanofiber
nanogel
nanomaterial
niosome
polylactic acid
polymersome
protein kinase B
quantum dot
silica nanoparticle
STAT1 protein
STAT3 protein
unclassified drug
biofilm
exosome
gingivitis
histopathology
human
hydrophilicity
hydrophobicity
micelle
nonhuman
particle size
patent
pathophysiology
periodontal pocket
periodontitis
prophylaxis
review
LA - English
PY - 2023
SN - ["2041-6008", "2041-5990"]
SP - 227-249
ST - Nanomaterials: an intra-periodontal pocket drug-delivery system for
periodontitis
T2 - Ther. Deliv.
TI - Nanomaterials: an intra-periodontal pocket drug-delivery system for
periodontitis
VL - 14
ID - 13120
ER -
TY - JOUR
AB - Backgound and Aim: Allopathic medications used for periodontal disease are
known to be associated with various side effects. Hence a search for
naturotherapies are on the rise. Among the natural pharmacons available aloevera
and propolis are considered to be effective and free from adverse effects. Taking
this into account, the present study was done to compare the plaque inhibiting
efficacies of Aloe vera and Propolis tooth gels in patients with chronic
periodontitis. Materials and Methods: Forty patients diagnosed with chronic
periodontitis were randomly allocated to groups A and B containing 20 patients
each. Patients in group A were advised to use Aloe vera tooth gel while those in
group B were advised to use Propolis tooth gel. Clinical and microbiologic
parameters using Polymerase chain reaction (PCR) were recorded at baseline and
after 3 months. Results: Student t-test was performed for all the obtained results.
In the Aloe vera group, comparison of baseline PCR and after 3 month results showed
reduction only in P. gingivalis (p=0.001), where as statistically significant
reduction in all the three red complex microorganisms was seen in propolis group.
All the clinical parameters (Plaque Index, Gingival Index, Bleeding on Probing,
Probing pocket Depth, and Clinical Attachment Level) in both the groups showed
statistically significant reductions after 3 months. Conclusion: Propolis showed a
statistically significant reduction in plaque, microbiologic and clinical
parameters. However, clinical trials of longer durations with larger sample sizes
are required to evaluate the efficacy.
AN - rayyan-563560374
AU - Kumar, A.
AU - Musalaiah, S. V. V. S.
AU - Pantareddy, I.
AU - Sudhakar, S.
DO - 10.7860/JCDR/2015/13185.6413
IS - 9
propolis
adult
article
clinical article
controlled study
drug efficacy
follow up
human
tooth plaque
Treponema denticola
LA - English
PY - 2015
SN - ["0973-709X", "2249-782X"]
SP - ZC01-ZC03
ST - Comparison of plaque inhibiting efficacies of aloe vera and propolis tooth
gels: A randomized PCR study
TI - Comparison of plaque inhibiting efficacies of aloe vera and propolis tooth
gels: A randomized PCR study
VL - 9
ID - 13748
ER -
TY - JOUR
AN - rayyan-563561696
AU - Kumaran, H.
AU - Gajendran, P. L.
AU - Arjunkumar, R.
AU - Rajesh, S.
IS - 51
PY - 2020
SP - 91-100
ST - Anti inflammatory activity of lycopene and its based chitosan
nanoformulation-an in vitro study
T2 - Plant Cell Biotechnology and Molecular Biology
TI - Anti inflammatory activity of lycopene and its based chitosan
nanoformulation-an in vitro study
85096701203&partnerID=40&md5=04dd31fddd98d3f3e791d2c1e6e57dd1
VL - 21
ID - 15070
ER -
TY - JOUR
AB - BACKGROUND: The present study was designed to evaluate effectiveness of 1.2%
atorvastatin (ATV) gel, as an adjunct to scaling and root planing (SRP) in the
treatment of intrabony defects in chronic periodontitis (CP) in patients with type
2 diabetes mellitus (t2DM). METHODS: Seventy-five patients were categorized into
two treatment groups: 1) SRP plus 1.2% ATV and 2) SRP plus placebo. Clinical
parameters including modified sulcus bleeding index, probing depth (PD), and
relative attachment level (RAL) were recorded at baseline and 3, 6, and 9 months.
Percentage radiographic defect depth reduction was evaluated using computer-aided
software at baseline and 6 and 9 months. RESULTS: Mean PD reduction and mean RAL
gain was greater in the ATV group than the placebo group at 3, 6, and 9 months.
Furthermore, ATV group sites presented with a significantly greater percentage of
radiographic defect depth reduction at 6 and 9 months. CONCLUSION: Locally
delivered ATV was found to be effective in treatment of intrabony defects in CP in
patients with t2DM.
AN - rayyan-563560332
AU - Kumari, M.
AU - Martande, S. S.
AU - Pradeep, A. R.
AU - Naik, S. B.
IS - 11
atorvastatin
alveolar bone loss
complication
controlled study
dental scaling
follow up
human
periodontal index
root planing
LA - English
PY - 2016
SN - 1943-3670
SP - 1278-1285
ST - Efficacy of Subgingivally Delivered 1.2% Atorvastatin in the Treatment of
Chronic Periodontitis in Patients With Type 2 Diabetes Mellitus: A Randomized
TI - Efficacy of Subgingivally Delivered 1.2% Atorvastatin in the Treatment of
Chronic Periodontitis in Patients With Type 2 Diabetes Mellitus: A Randomized
VL - 87
ID - 13706
ER -
TY - JOUR
AB - In situ gelling syringeable periodontal sol capable of dual controlled
delivery of metronidazole benzoate and serratiopeptidase was designed based on 23
factorial design with drug, poloxamer 407 and aerosil as independent variables and
sol gel transition characteristics, %CDR48h and palatability as responses. The sols
had agreeable taste, were mucoadhesive, syringeable and inverted into gels at
periodontal cavity temperature. F8 with optimal drug release was identified as the
best formulation. The dispersion characteristics of poloxamer significantly
affected the pharmacotechnical properties of the in situ gelling systems. Extra
design checkpoint generated using Design Expert software 8.02 (Stat-Ease, USA)
validated the experimental design. Thus a thermoreversible, in situ gelling and
syringeable periodontal sol with acceptable taste characteristics that offered
controlled release of metronidazole benzoate and serratiopeptidase was developed
for application into the periodontal pocket. The developed optimized sol was
satisfactory in terms of taste, syringeability, palatability and incorporation of
serratiopeptidase as anti-inflammatory agent, has the potential of developing a
therapeutically efficacious system for treatment of periodontal inflammatory
anaerobic infections. © 2012 Bentham Science Publishers.
AN - rayyan-563560560
AU - Kumari, N.
AU - Pathak, K.
DO - 10.2174/156720112798375998
IS - 1
gelling agent
serratiopeptidase
anaerobic infection
article
software
drug design
drug efficacy
drug formulation
drug screening
drug solubility
drug stability
dual controlled release
flow kinetics
palatability
periodontics
pH
phase transition
priority journal
thermal analysis
viscosity
LA - English
PY - 2012
SN - ["1567-2018", "1875-5704"]
SP - 74-84
ST - Dual controlled release, in situ gelling periodontal sol of metronidazole
benzoate and serratiopeptidase: Statistical optimization and mechanistic evaluation
T2 - Curr. Drug Deliv.
TI - Dual controlled release, in situ gelling periodontal sol of metronidazole
benzoate and serratiopeptidase: Statistical optimization and mechanistic evaluation
VL - 9
ID - 13934
ER -
TY - JOUR
AB - Background: Halitosis or bad breath is a symptom in which a noticeably
unpleasant breath odour is present due to an underlying oral or systemic disease.
50% to 60% of the world population has experienced this problem which can lead to
social stigma and loss of self-confidence. Multiple interventions have been tried
to control halitosis ranging from mouthwashes and toothpastes to lasers. This new
Cochrane Review incorporates Cochrane Reviews previously published on tongue
scraping and mouthrinses for halitosis. Objectives: The objectives of this review
were to assess the effects of various interventions used to control halitosis due
to oral diseases only. We excluded studies including patients with halitosis
secondary to systemic disease and halitosis-masking interventions. Search methods:
Cochrane Oral Health's Information Specialist searched the following databases:
Cochrane Oral Health's Trials Register (to 8 April 2019), the Cochrane Central
Register of Controlled Trials (CENTRAL; 2019, Issue 3) in the Cochrane Library
(searched 8 April 2019), MEDLINE Ovid (1946 to 8 April 2019), and Embase Ovid (1980
to 8 April 2019). We also searched LILACS BIREME (1982 to 19 April 2019), the
National Database of Indian Medical Journals (1985 to 19 April 2019), OpenGrey
(1992 to 19 April 2019), and CINAHL EBSCO (1937 to 19 April 2019). The US National
Institutes of Health Ongoing Trials Register ClinicalTrials.gov (8 April 2019), the
World Health Organization International Clinical Trials Registry Platform (8 April
2019), the ISRCTN Registry (19 April 2019), the Clinical Trials Registry - India
(19 April 2019), were searched for ongoing trials. We also searched the cross-
references of included studies and systematic reviews published on the topic. No
restrictions were placed on the language or date of publication when searching the
electronic databases. Selection criteria: We included randomised controlled trials
(RCTs) which involved adults over the age of 16, and any intervention for managing
halitosis compared to another or placebo, or no intervention. The active
interventions or controls were administered over a minimum of one week and with no
upper time limit. We excluded quasi-randomised trials, trials comparing the results
for less than one week follow-up, and studies including advanced periodontitis.
Data collection and analysis: Two pairs of review authors independently selected
trials, extracted data, and assessed risk of bias. We estimated mean differences
(MDs) for continuous data, with 95% confidence intervals (CIs). We assessed the
certainty of the evidence using the GRADE approach. Main results: We included 44
trials in the review with 1809 participants comparing an intervention with a
placebo or a control. The age of participants ranged from 17 to 77 years. Most of
the trials reported on short-term follow-up (ranging from one week to four weeks).
Only one trial reported long-term follow-up (three months). Three studies were at
low overall risk of bias, 16 at high overall risk of bias, and the remaining 25 at
unclear overall risk of bias. We compared different types of interventions which
were categorised as mechanical debridement, chewing gums, systemic deodorising
agents, topical agents, toothpastes, mouthrinse/mouthwash, tablets, and combination
methods. Mechanical debridement: for mechanical tongue cleaning versus no tongue
cleaning, the evidence was very uncertain for the outcome dentist-reported
organoleptic test (OLT) scores (MD -0.20, 95% CI -0.34 to -0.07; 2 trials, 46
participants; very low-certainty evidence). No data were reported for patient-
reported OLT score or adverse events. Chewing gums: for 0.6% eucalyptus chewing gum
versus placebo chewing gum, the evidence was very uncertain for the outcome
dentist-reported OLT scores (MD -0.10, 95% CI -0.31 to 0.11; 1 trial, 65
reported OLT score or adverse events. Systemic deodorising agents: for 1000 mg
champignon versus placebo, the evidence was very uncertain for the outcome p tient-
reported visual analogue scale (VAS) scores (MD -1.07, 95% CI -14.51 to 12.37; 1
trial, 40 participants; very low-certainty evidence). No data were reported for
dentist-reported OLT score or adverse events. Topical agents: for hinokitiol gel
versus placebo gel, the evidence was very uncertain for the outcome dentist-
reported OLT scores (MD -0.27, 95% CI -1.26 to 0.72; 1 trial, 18 participants; very
low-certainty evidence). No data were reported for patient-reported OLT score or
adverse events. Toothpastes: for 0.3% triclosan toothpaste versus control
toothpaste, the evidence was very uncertain for the outcome dentist-reported OLT
scores (MD -3.48, 95% CI -3.77 to -3.19; 1 trial, 81 participants; very low-
certainty evidence). No data were reported for patient-reported OLT score or
adverse events. Mouthrinse/mouthwash: for mouthwash containing chlorhexidine and
zinc acetate versus placebo mouthwash, the evidence was very uncertain for the
outcome dentist-reported OLT scores (MD -0.20, 95% CI -0.58 to 0.18; 1 trial, 44
reported OLT score or adverse events. Tablets: no data were reported on key
outcomes for this comparison. Combination methods: for brushing plus cetylpyridium
mouthwash versus brushing, the evidence was uncertain for the outcome dentist-
reported OLT scores (MD -0.48, 95% CI -0.72 to -0.24; 1 trial, 70 participants;
adverse events. Authors' conclusions: We found low- to very low-certainty evidence
to support the effectiveness of interventions for managing halitosis compared to
placebo or control for the OLT and patient-reported outcomes tested. We were unable
to draw any conclusions regarding the superiority of any intervention or
concentration. Well-planned RCTs need to be conducted by standardising the
interventions and concentrations.
AN - rayyan-563560164
AU - Kumbargere Nagraj, S.
AU - Eachempati, P.
AU - Uma, E.
AU - Singh, V. P.
AU - Ismail, N. M.
AU - Varghese, E.
DO - 10.1002/14651858.CD012213.pub2
IS - 12
KW - 000002145
000002713
000023832
00005334
00010618
2007-003756-11
201105136466N1
201404004519
2014121520314N1
2015030921395N1
20151109001
2016012026122N1
201805014049
201806014686
3240
ISRCTN67671859
ISRCTN74655176
ISRCTN75902618
NCT00250289
NCT00655772
NCT00748943
NCT00875927
NCT02194621
NCT02628938
NCT02789436
NCT02794766
NCT03031756
NCT03053882
NCT03160573
NCT03346460
NCT03468595
NCT03591484
NCT03656419
actinidine plus protease cysteine
Agaricus bisporus extract
arginine
benzethonium chloride
bicarbonate
chlorhexidine
chlorine dioxide
dimethyl sulfide
essential oil
fungal extract
gluconate zinc
hydrogen sulfide
lactoperoxidase
maleic acid
methanethiol
mouthwash
placebo
povidone iodine
propolis
proteinase
pycnogenol
sodium fluoride
thujaplicin
toothpaste
triclosan
unclassified drug
unindexed drug
zinc
zinc acetate
Agaricus bisporus
chewing gum
Cymbopogon citratus
dental polishing
dental scaling
Eucalyptus
halitosis
human
intermethod comparison
Lactobacillus salivarius
lozenge
mechanical debridement
mechanical tongue cleaning
mouth hygiene
priority journal
review
root planing
systematic review
tablet
tea
tooth brushing
treatment outcome
visual analog scale
LA - English
PY - 2019
SN - 1469-493X
ST - Interventions for managing halitosis
T2 - Cochrane Database Syst. Rev.
TI - Interventions for managing halitosis
VL - 2019
ID - 13538
ER -
TY - JOUR
AB - Objectives: This study aimed to evaluate the impact of chlorhexidine (CHX)
gel on inflammation-induced periodontal tissue destruction, osteoclastogenesis,
subgingival microbiota, and on the modulation of the RANKL/OPG as well as
inflammatory mediators during bone remodeling in vivo. Materials and methods:
Ligation- and LPS injection-induced experimental periodontitis were created to
investigate the effect of topical application of CHX gel in vivo. Alveolar bone
loss, osteoclast number and gingival inflammation was evaluated by micro-CT,
histological, immunohistochemistry and biochemical analysis. The composition of the
subgingival microbiota was characterized by 16S rRNA gene sequencing. Results: Data
shows significant decreases in the alveolar bone destruction in rats from ligation-
plus-CHX gel group compared to ligation group. In addition, significant decreases
in the number of osteoclasts on bone surface and the protein level of receptor
activator of nuclear factor κB ligand (RANKL) in gingival tissue were observed in
rats from ligation-plus-CHX gel group. Moreover, data shows significantly decreased
inflammatory cell infiltration and decreased expression of cyclooxygenase (COX-2)
and inducible NO synthase (iNOS) in gingival tissue from ligation-plus-CHX gel
group versus ligation group. Assessment of the subgingival microbiota revealed
changes in rats with CHX gel application treatment. Conclusion: HX gel presents
protective effect on gingival tissue inflammation, osteoclastogenesis, RANKL/OPG
expression, inflammatory mediators, and alveolar bone loss in vivo, which may have
a translational impact on the adjunctive use in the management of inflammation-
induced alveolar bone loss.
AN - rayyan-563559681
AU - Kuo, T. Y.
AU - Hsieh, M. C.
AU - Cheng, C. D.
AU - Huang, R. Y.
AU - Van Dyke, T. E.
AU - Sung, C. E.
AU - Wang, C. Y.
AU - Hsieh, Y. S.
AU - Cheng, W. C.
DO - 10.1016/j.jfma.2023.02.001
IS - 9
KW - imaging software
insulin syringe
pre-clinical imaging device
acid phosphatase tartrate resistant isoenzyme
cyclooxygenase 2
gel
lipopolysaccharide
osteoprotegerin
receptor activator of nuclear factor kappa B
RNA 16S
Alistipes
alveolar bone
alveolar bone loss
alveolar crest
animal experiment
animal model
animal tissue
article
Bacteroides
Bacteroidetes
Bifidobacterium
bone destruction
bone remodeling
cell infiltration
Clostridium
connective tissue
controlled study
Enterococcaceae
Enterococcus
Escherichia
Firmicutes
gingival tissue
gingivitis
histopathology
in vivo study
inflammatory cell
Lactobacillaceae
Lactobacillus
ligation
male
maxillary first molar
maxillary second molar
maxillary third molar
microbial community
mouth flora
multinuclear cell
nonhuman
osteoclast
osteoclastogenesis
osteolysis
Proteobacteria
Proteus
rat
RNA sequencing
Shigella
species composition
Staphylococcus
topical treatment
Western blotting
perioxidin
LA - English
PY - 2023
SN - ["1876-0821", "0929-6646"]
SP - 899-910
ST - Chlorhexidine gel topical application ameliorates inflammatory bone loss in
T2 - J. Formos. Med. Assoc.
TI - Chlorhexidine gel topical application ameliorates inflammatory bone loss in
VL - 122
ID - 13055
ER -
TY - JOUR
AB - Some studies showed positive results in testing the efficacy of sanguinarine
delivered as oral rinse or dentifrice against plaque and gingivitis. The
application of a gel containing 0.05 and 0.5% sanguinarine using special trays did
not prevent plaque formation in regions with no oral hygiene. In contrast to
placebo the 0.5% sanguinaria-gel was able to retard the formation of an
experimental gingivitis. Chlorhexidine was superior to sanguinarine. Side effects
were not detected.
AN - rayyan-563561170
AU - Kurbad, A.
AU - Gängler, P.
AU - Kaufmann, K.
IS - 4
KW - alkaloid
benzophenanthridine derivative
chlorhexidine
isoquinoline derivative
sanguinarine
adult
article
clinical trial
comparative study
controlled study
gingivitis
human
tooth plaque
LA - German
PY - 1990
SN - 0302-4725
SP - 157-159
ST - Evaluation of the efficacy of sanguinarine using the experimental gingivitis
model
T2 - Prüfung von Sanguinaria-Alkaloiden am Modell der experimentellen Gingivitis.
TI - Evaluation of the efficacy of sanguinarine using the experimental gingivitis
model
VL - 40
ID - 14544
ER -
TY - JOUR
AB - A cytoplasmic soluble fraction of Actinobacillus actinomycetemcomitans Y4 was
isolated and characterized as suppressing mitogen-stimulated proliferation of and
cytokine production by C3H/HeN mouse splenic T cells. This factor, designated
suppressive factor 1 (SF1), was isolated from the supernatant of sonicated whole
bacteria and purified by Q-Sepharose Fast Flow column chromatography, DEAE-
Sepharose Fast Flow column chromatography, hydroxyapatite high-pressure liquid
chromatography (HPLC), and Protein Pack 300 and 125 gel filtration HPLC. Sodium
dodecyl sulfate-polyacrylamide gel electrophoresis analysis revealed that the
purified SF1 migrated as a single band corresponding to a molecular mass of 14 kDa.
This molecule was protease labile, heat resistant, and noncytotoxic. N'-terminal
sequence analysis revealed no homology with any known peptides of periodontopathic
bacteria or with any host-derived growth factors. Purified SF1 suppressed the
proliferation of mouse splenic T cells which had been stimulated with concanavalin
A, as well as suppressing the production of interleukin-2 (IL- 2), gamma
interferon, IL-4, and IL-5 from CD4+ T cells at 0.1 μg/ml or more. These data
suggest that SF1 produced by the periodontal pathogen A. actinomycetemcomitans
functions as a virulence factor by down regulating T- cell proliferation and
cytokine production at local defense sites.
AN - rayyan-563561068
AU - Kurita-Ochiai, T.
AU - Ochiai, K.
DO - 10.1128/iai.64.1.50-54.1996
IS - 1
KW - CD4 antigen
gamma interferon
interleukin 2
interleukin 4
interleukin 5
virulence factor
animal experiment
article
down regulation
host resistance
immunoregulation
lymphocyte proliferation
mouse
nonhuman
priority journal
sequence analysis
LA - English
PY - 1996
SN - 0019-9567
SP - 50-54
ST - Immunosuppressive factor from Actinobacillus actinomycetemcomitans down
regulates cytokine production
T2 - INFECT. IMMUN.
TI - Immunosuppressive factor from Actinobacillus actinomycetemcomitans down
regulates cytokine production
VL - 64
ID - 14442
ER -
TY - JOUR
AB - The aim of this study was to examine the bactericidal effects and
bactericidal time of an acidified sodium chlorite compound gel (ASC-Gel) on
bacteria isolated from the peri-implant sulci of 10 patients who received implants
3-27 years previously, and the depth of each peri-implant sulcus was 5 mm or less.
Porphyromonas gingivalis (ATCC33277) was used as the control bacterium. Five ASC-
Gel preparations were created by adding 3.3%, 5.0%, 7.0%, 9.0%, and 11.0% citric
acid (CA) (condition a, b, c, d, and e, respectively) into an oral moisturizing gel
containing sodium chlorite. The concentrations of chlorine dioxide (ClO2) generated
in ASC-Gel under conditions (a) to (e) were 12.1, 14.1, 17.2, 21.2, and 39.3 ppm,
respectively. We examined the bactericidal effects of the 5 ASC-Gel preparations at
volumes of 0.5, 1.0, and 2.0 mL, and measured the bactericidal time when 2.0 mL of
ASC-Gel was used under condition (e). The bactericidal effects of ASC-Gel became
significantly greater with increased concentrations of CA and ClO2 and with
increased usage (0.5-2.0 mL) of the gel. All bacteria were killed by using 2.0 mL
of ASC-Gel under condition (e). ASC-Gel also needed between 45 and 90 minutes to
kill all microbes under condition (e). Within the limits of the present
investigation, these results suggest that ASC-Gel is useful as a chemical
disinfectant against bacteria in the peri-implant sulcus. Further studies are also
required to protect teeth, the surface of hydroxyapatite-coated implants, and the
surrounding soft tissues from effects of chemical dissolution such as acid erosion
due to the low pH of ASC-Gel.
AN - rayyan-563560462
AU - Kuroyama, I.
AU - Osato, S.
AU - Ogawa, T.
IS - 6
KW - acid
chloride
chlorite
disinfectant agent
lubricating agent
mouthwash
aged
anaerobic bacterium
article
chemistry
drug effect
female
gel
gingivitis
human
male
microbiology
middle aged
pH
pilot study
LA - English
PY - 2013
SN - 0160-6972
SP - 689-695
ST - The bactericidal effects of an acidified sodium chlorite-containing oral
moisturizing gel: a pilot study
T2 - J Oral Implantol
TI - The bactericidal effects of an acidified sodium chlorite-containing oral
moisturizing gel: a pilot study
VL - 39
ID - 13836
ER -
TY - JOUR
AN - rayyan-563561870
AU - Kush, A.
AU - Thakur, R.
AU - Patil, S. D. S.
AU - Paul, S.
AU - Kakanur, M.
DO - 10.4103/0976-237X.169860
IS - 4
PY - 2015
SP - 534-538
ST - Evaluation of antimicrobial action of Carie Care™ and Papacarie Duo™ on
Aggregatibacter actinomycetemcomitans a major periodontal pathogen using polymerase
chain reaction
T2 - Contemporary Clinical Dentistry
TI - Evaluation of antimicrobial action of Carie Care™ and Papacarie Duo™ on
chain reaction
84948734949&doi=10.4103%2f0976-
237X.169860&partnerID=40&md5=79526a90cd03a01272680cb3c07e1157
VL - 6
ID - 15244
ER -
TY - JOUR
AB - BACKGROUND: In the present scenario, we are made available with
chemomechanical caries removal system containing a natural proteolytic enzyme for
the ease in the excavation of infected dentine. The additive action for these
agents is providing antimicrobial and anti-inflammatory properties. AIM: This study
was undertaken for assessing the action of Carie Care™ and Papacarie Duo™ on
Aggregatibacter actinomycetemcomitans. MATERIALS AND METHODS: The samples were
collected for cultivation of the periodontal pathogen from the clinical periodontal
pockets using sterile paper points. The samples cultured under suitable conditions
were analyzed with quantitative polymerase chain reaction targeting 16s r-DNA. The
samples were divided into three groups namely, Group A: Control, Group B: With
Papacarie Duo, Group C: With Carie Care. The pathogen inoculums plugs were inserted
in the petri dishes containing chemically defined medium and the experimental gels
at different concentrations and were incubated under optimal conditions. The
inhibition of growth of the pathogen was studied visually. RESULTS: There was
visual inhibition of growth for Group B and C and also exhibited a dose-dependent
effect also. CONCLUSION: Based on the results of the present study, Carie Care™ gel
demonstrated better antimicrobial action against A. actinomycetemcomitans which is
a major periodontal disease causing pathogen.
AN - rayyan-563561130
AU - Kush, A.
AU - Thakur, R.
AU - Patil, S. D.
AU - Paul, S. T.
AU - Kakanur, M.
DO - 10.4103/0976-237X.169860
IS - 4
J2 - Contemp Clin Dent
LA - eng
N1 - Director Research, Vittal Mallya Scienticic Research Foundation, Bengaluru,
Karnataka, India.; Department of Pedodontics and Preventive Dentistry, K.L.E
Society's Institute of Dental Sciences, Bengaluru, Karnataka, India.; Department of
Pedodontics and Preventive Dentistry, K.L.E Society's Institute of Dental Sciences,
Bengaluru, Karnataka, India.; Department of Pedodontics and Preventive Dentistry,
Sir Rajiv Gandhi College of Dental Sciences and Hospital, Bengaluru, Karnataka,
India.; Department of Pedodontics and Preventive Dentistry, K.L.E Society's
Institute of Dental Sciences, Bengaluru, Karnataka, India.
PY - 2015
SN - 0976-237X (Print)
SP - 534-8
ST - Evaluation of antimicrobial action of Carie Care™ and Papacarie Duo™ on
chain reaction
T2 - Contemporary clinical dentistry
TI - Evaluation of antimicrobial action of Carie Care™ and Papacarie Duo™ on
chain reaction
VL - 6
Y2 - 10
ID - 14504
ER -
TY - JOUR
AB - Objective: Aberrant matrix metalloproteinase (MMP) and human P-defensin (HBD)
functions have been found in inflammatory diseases. The objectives of this study
were to investigate the immunolocalisation, mRNA expression and molecular forms of
MMP-25, MMP-26, HBD-1 and HBD-2 in chronic and aggressive periodontitis and in
peri-implantitis. The expression of MMP-25 by cultured human plasmacytoma cells and
macrophages, and the effects of MMP-26 and Porphyromonas gingivalis trypsin-like
proteinase on HBD-1 and -2 were also studied. Design: Immunohistochemistry,
immunofluorescent analysis, reverse transcriptase polymerase chain reaction and
immunoblotting were used to assess localisation, mRNA expression and molecular
forms of MMP-25, MMP-26, HBD-1 and HBD-2. HBD degradation by MMP-26 and P.
gingivalis proteinase was studied by sodium dodecyl sulphate-polyacrylamide gel
electrophoresis. Results: MMP-25 was present in plasma cells and polymorphonuclear
leucocytes, and MMP-26 was present in oral and sulcular basement membrane zones.
HBD-1 was distributed perivasculary in gingival connective tissue and in oral and
sulcular epithelium, and HBD-2 was found to a lesser extent in the perivascular
space. Low MMP-2S, MMP-26, HBD-1 and HBD-2 mRNA expression was found. Immunoblot
revealed 29-57-kDa MMP-25 in myeloma cell lysates, but not in macrophages, and
partly activated MMP-25 and -26 in diseased gingival crevicular fluid and peri-
implant sulcular fluid. P. gingivalis trypsin-like proteinase degraded HBD-1 and -
2. Conclusions: Both MMP-25 and -26 were expressed more strongly in extensively
inflamed gingiva compared with healthy gingiva. The expression of HBD-1 was
stronger than that of HBD-2 in periodontitis and peri-implantitis. De-novo
expression of MMP-25 and -26 is associated with periodontal and peri-implant
inflammation. Furthermore, P. gingivalis trypsin-like proteinase, but not MMP-26,
can degrade HBD-1 and -2, which could lead to a weakened innate immune response.
(C) 2007 Elsevier Ltd. All rights reserved.
AN - rayyan-563562400
AU - Kuula, H.
AU - Salo, T.
AU - Pirila, E.
AU - Hagstrom, J.
AU - Luomanen, M.
AU - Gutierrez-Fernandez, A.
AU - Romanos, G. E.
AU - Sorsa, T.
DO - 10.1016/j.archoralbio.2007.09.010
IS - 2
PY - 2008
SN - ["0003-9969", "1879-1506"]
SP - 175-186
ST - Human beta-defensin-1 and -2 and matrix metalloproteinase-25 and -26
expression in chronic and aggressive periodontitis and in peri-implantitis
TI - Human beta-defensin-1 and -2 and matrix metalloproteinase-25 and -26
expression in chronic and aggressive periodontitis and in peri-implantitis
VL - 53
Y2 - 2
ID - 15774
ER -
TY - JOUR
AB - Objective: Aberrant matrix metalloproteinase (MMP) and human β-defensin (HBD)
functions have been found in inflammatory diseases. The objectives of this study
were to investigate the immunolocalisation, mRNA expression and molecular forms of
MMP-25, MMP-26, HBD-1 and HBD-2 in chronic and aggressive periodontitis and in
peri-implantitis. The expression of MMP-25 by cultured human plasmacytoma cells and
macrophages, and the effects of MMP-26 and Porphyromonas gingivalis trypsin-like
proteinase on HBD-1 and -2 were also studied. Design: Immunohistochemistry,
immunofluorescent analysis, reverse transcriptase polymerase chain reaction and
immunoblotting were used to assess localisation, mRNA expression and molecular
forms of MMP-25, MMP-26, HBD-1 and HBD-2. HBD degradation by MMP-26 and P.
gingivalis proteinase was studied by sodium dodecyl sulphate-polyacrylamide gel
electrophoresis. Results: MMP-25 was present in plasma cells and polymorphonuclear
leucocytes, and MMP-26 was present in oral and sulcular basement membrane zones.
HBD-1 was distributed perivasculary in gingival connective tissue and in oral and
sulcular epithelium, and HBD-2 was found to a lesser extent in the perivascular
space. Low MMP-25, MMP-26, HBD-1 and HBD-2 mRNA expression was found. Immunoblot
revealed 29-57-kDa MMP-25 in myeloma cell lysates, but not in macrophages, and
partly activated MMP-25 and -26 in diseased gingival crevicular fluid and peri-
implant sulcular fluid. P. gingivalis trypsin-like proteinase degraded HBD-1 and -
2. Conclusions: Both MMP-25 and -26 were expressed more strongly in extensively
inflamed gingiva compared with healthy gingiva. The expression of HBD-1 was
stronger than that of HBD-2 in periodontitis and peri-implantitis. De-novo
expression of MMP-25 and -26 is associated with periodontal and peri-implant
inflammation. Furthermore, P. gingivalis trypsin-like proteinase, but not MMP-26,
can degrade HBD-1 and -2, which could lead to a weakened innate immune response. ©
2007 Elsevier Ltd. All rights reserved.
AN - rayyan-563560722
AU - Kuula, H.
AU - Salo, T.
AU - Pirilä, E.
AU - Hagström, J.
AU - Luomanen, M.
AU - Gutierrez-Fernandez, A.
AU - Romanos, G. E.
AU - Sorsa, T.
DO - 10.1016/j.archoralbio.2007.09.010
IS - 2
beta defensin
adolescent
adult
aged
article
chronic disease
female
gene expression
genetics
gingivitis
human
male
metabolism
methodology
middle aged
periodontitis
tooth implantation
LA - English
PY - 2008
SN - 0003-9969
SP - 175-186
ST - Human β-defensin-1 and -2 and matrix metalloproteinase-25 and -26 expression
in chronic and aggressive periodontitis and in peri-implantitis
TI - Human β-defensin-1 and -2 and matrix metalloproteinase-25 and -26 expression
in chronic and aggressive periodontitis and in peri-implantitis
VL - 53
ID - 14096
ER -
TY - JOUR
AB - Many new bacteria have been isolated from subgingival pockets, but at this
time, Centipeda periodontii (C.p.) seems to be overlooked in recent publications of
oral microbiology. C.p. is a new species described in 1983 by C.H., Lai et al. (1).
This organism is very easy to characterise presenting as large anaerobic serpentine
motile Gram negative bacteria; they are saccharolytic and produce propionic acid.
The purpose of this study is to evaluate frequency of recovery from acute
periodontitis, to assess biochemical and morphological features, to study fatty
acid methylester profiles and end products of fermentation, and to test the
susceptibility of the organism to antibiotics usually used in periodontal
treatment. The recovery of C.p. is very poor with the conventional methods of
sampling. With the capillary method, the recovery increases tenfold. In this study,
it often appeared associated with Fusobacterium nucleatum, Bacteroides gingivalis,
Bacteroides intermedius, Wolinella recta, Selenomonas sp., and Treponema sp., whose
populations are usually increased in active sites. Our isolates were obtained from
active periodontal pockets presenting more than 4 mm in depth. The pathogenicity of
C.p. has not yet been determined, but it has not been detected in samples taken
from healthy sites. A study by B.J. Shenker et al., showed that C.p. has
immunosuppressive effects (2). This organism may be considered as a good marker of
acute periodontitis, like Actinobacillus actinomycetemcomitans, Bacteroides
gingivalis and Bacteroides intermedius.
AN - rayyan-563561167
AU - Labbe, M.
AU - Sauvetere, E.
AU - Pourtois, M.
AU - Yourassowsky, E.
chloramphenicol
clindamycin
erythromycin
metronidazole
minocycline
bacterium isolation
biotypology
clinical article
conference paper
fermentation
human
microscopy
morphology
periodontal disease
sampling
LA - French
PY - 1990
SN - 0399-077X
SP - 183-186
ST - Centipeda periodontii. An overlooked bacterium in periodontal bacteriology
T2 - MED. MAL. INFECT.
TI - Centipeda periodontii. An overlooked bacterium in periodontal bacteriology
VL - 20
ID - 14541
ER -
TY - JOUR
AB - Eleven strains of Eikenella corrodens with beta-lactamase activity were
isolated from a patient with refractory periodontitis who had previously been
treated with penicillin antibiotics. These strains were relatively resistant to
benzylpenicillin, amoxicillin, and ampicillin (MICs, less-than-or-equal-to 64-mu-
g/ml); susceptible to amoxicillin-clavulanate (2:1) (MICs, less-than-or-equal-to 4-
mu-g/ml); and moderately susceptible to cephalothin and cephaloridine (MICs, 0.12
to 16-mu-g/ml). The addition of 1-mu-g of potassium clavulanate, a beta-lactamase
inhibitor, per ml resulted in a significant increase in the susceptibilities of
these strains to penicillins but not to cephalosporins. Potassium clavulanate had
no effect on non-beta-lactamase-producing strains. Enzyme production was
constitutive since activity was not increased when cells were cultivated in the
presence of benzylpenicillin. Enzyme activity was strongly inhibited by potassium
clavulanate, sulbactam, and iodine; weakly inhibited by cloxacillin, imipenem, and
moxalactam; but not inhibited by aztreonam, EDTA, or p-chloromercuribenzoate. By
gel filtration, the enzyme had an estimated molecular mass of 29 kDa. Isoelectric
focusing of the partially purified enzyme gave a major beta-lactamase band at pH
5.50 and a minor band at pH 5.60. Plasmids were not detected in any of the 11 beta-
lactamase-positive strains. This enzyme is considered to belong to class 2a of the
Bush classification scheme.
AN - rayyan-563562575
AU - Lacroix, J. M.
AU - Walker, C.
DO - 10.1128/AAC.35.5.886
IS - 5
PY - 1991
SN - 0066-4804
SP - 886-891
ST - CHARACTERIZATION OF A BETA-LACTAMASE FOUND IN EIKENELLA-CORRODENS
T2 - ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
TI - CHARACTERIZATION OF A BETA-LACTAMASE FOUND IN EIKENELLA-CORRODENS
VL - 35
Y2 - 5
ID - 15949
ER -
TY - JOUR
AB - Eleven strains of Eikenella corrodens with β-lactamase activity were isolated
from a patient with refractory periodontitis who had previously been treated with
penicillin antibiotics. These strains were relatively resistant to
benzylpenicillin, amoxicillin, and ampicillin (MICs, ≥64 μg/ml); susceptible to
amoxicillin-clavulanate (2:1) (MICs, ≤4 μg/ml); and moderately susceptible to
cephalothin and cephaloridine (MICs, 0.12 to 16 μg/ml). The addition of 1 μg of
potassium clavulanate, a β-lactamase inhibitor, per ml resulted in a significant
increase in the susceptibilities of these strains to penicillins but not to
cephalosporins. Potassium clavulanate had no effect on non-β-lactamase-producing
strains. Enzyme production was constitutive since activity was not increased when
cells were cultivated in the presence of benzylpenicillin. Enzyme activity was
strongly inhibited by potassium clavulanate, sulbactam, and iodine; weakly
inhibited by cloxacillin, imipenem, and moxalactam; but not inhibited by aztreonam,
EDTA, or p-chloromercuribenzoate. By gel filtration, the enzyme had an estimated
molecular mass of 29 kDa. Isoelectric focusing of the partially purified enzyme
gave a major β-lactamase band at pH 5.50 and a minor band at pH 5.60. Plasmids were
not detected in any of the 11 β-lactamase-positive strains. This enzyme is
considered to belong to class 2a of the Bush classification scheme.
AN - rayyan-563561160
AU - Lacroix, J. M.
AU - Walker, C.
DO - 10.1128/AAC.35.5.886
IS - 5
KW - amoxicillin
ampicillin
aztreonam
beta lactamase
carbenicillin
cefaloridine
cefalotin
cefotaxime
clavulanic acid
cloxacillin
imipenem
iodine
latamoxef
nitrocefin
penicillin G
article
drug resistance
Eikenella corrodens
enzyme activity
enzyme analysis
enzyme induction
enzyme inhibition
enzyme purification
human
nonhuman
periodontitis
priority journal
LA - English
PY - 1991
SN - 0066-4804
SP - 886-891
ST - Characterization of a β-lactamase found in Eikenella corrodens
T2 - ANTIMICROB. AGENTS CHEMOTHER.
TI - Characterization of a β-lactamase found in Eikenella corrodens
VL - 35
ID - 14534
ER -
TY - JOUR
AB - There is increasing public interest in natural or herbal-based healthcare
products. This trend is not only visible in supermarkets and dental practices, but
also in the scientific world. An improving number of clinical trials are being
conducted to validate the claims made about these products in regards to
periodontal health. Among single component preparations,Aloe veraand green tea are
the most studied natural ingredients. Concerning polyherbal mixtures, triphala has
garnered great interest. The effects of these natural products on periodontal
health is encouraging, with almost all studies showing an inhibitory effect on
plaque accumulation and an improvement in gingival health. However, more studies
are needed to be able to design clinical guidelines to guide the use of these
natural products in periodontal practice. For most of these products, few studies
are available and, moreover, the available studies are limited in duration, the
number of participants, and the specific composition of the natural product is
often not described in detail.
AN - rayyan-563562337
AU - Laleman, I.
AU - Teughels, W.
DO - 10.1111/prd.12339
IS - 1
PY - 2020
SN - ["0906-6713", "1600-0757"]
SP - 102-123
ST - Novel natural product-based oral topical rinses and toothpastes to prevent
TI - Novel natural product-based oral topical rinses and toothpastes to prevent
VL - 84
Y2 - 10
ID - 15711
ER -
TY - JOUR
AB - Chitosan is a natural polysaccharide with great potential for biomedical
applications due to its biocompatibility, biodegradable capability, and
nontoxicity. Various techniques used for preparing chitosan microspheres/ membranes
and evaluations of these fabrications have also been reviewed. The hydrophilicity
of chitosan provides unique characteristics of hydrogel formation with the acidic
media and may entrap the drug content inside of the matrix for controlled release.
In order to improve upon the scope of preparation of chitosan microspheres, we had
successfully employed and incorporated a high-voltage system into the direct
pumping injection process. The wide range of drug release profiles could be
attributed to the surface characteristics, porosities, and various structures of
chitosan microspheres upon treatment with Na5P3O10/NaOH solutions of various volume
ratios. We also demonstrated that with the addition of chitosan/β-TCP microspheres
as a constituent into the PMMA cement significantly decreases the curing peak
temperature and increases the setting time. The excellent gelforming property of
chitosan offers another biomedical application in membrane separation fields.
Chitosan membranes were prepared by a thermal induced phase separation method,
following treatment with nontoxic NaOH gelating and Na 5P3O10, Na2SO3 crosslinking
agents. In order to further improve the mechanical strength and biocompatibility
and to expand the potential of chitosan GTR membranes in periodontal applications,
various chitosan membranes incorporating with negatively charged alginate,
bioactive tricalcium phosphate, and platelet rich plasma, respectively, were also
prepared and characterized. Moreover, we had also utilized chitosan, which with
good blood-clotting, cheap, and easy preparation characteristics, as the raw
material to prepare rapid clotting wound dressing and tooth plug. © 2011 National
Taiwan University.
AN - rayyan-563560604
AU - Lan, C. W.
AU - Niu, G. C. C.
AU - Chang, S. J.
AU - Yao, C. H.
AU - Kuo, S. M.
DO - 10.4015/S1016237211002372
IS - 1
KW - alginic acid
calcium phosphate
chitosan
gentamicin bone cement
hydroxyapatite
microsphere
sodium hydroxide
vasculotropin
article
biocompatibility
human
hydrogel
hydrophilicity
medical technology
nonhuman
phase separation
porosity
tensile strength
wound dressing
LA - English
PY - 2011
SN - 1016-2372
SP - 51-62
ST - Chitosan in applications of biomedical devices
T2 - Biomed. Eng. Appl. Basis Commun.
TI - Chitosan in applications of biomedical devices
VL - 23
ID - 13978
ER -
TY - JOUR
AB - The antimicrobial effects of subgingival chlorhexidine (CH) irrigations on
the pathogenic flora in advanced periodontal lesions were assessed. Changes in the
patterns of colonization within the subgingival sites were monitored by
differential dark-field microscopy, in 16 patients, over a period of 10 weeks. In
addition, changes in the clinical parameters of the diseased sites were also
monitored. Initial base-line evaluations were made for both the clinical and
microbiological parameters. 4 sites of moderate to advanced periodontal disease
were selected in each patient. These were randomly irrigated with a single dose of
either 0.2% CH gel, 0.2% CH solution, or physiological saline, while 1 site was
left as a control. The patients were seen weekly, until the 5th week, then at the
7th and 10th weeks. At each appointment, a microbiological sample was taken from
the subgingival region of each site, together with an assessment of the clinical
indices. Results indicated that a single irrigation of an 0.2% solution of CH or
0.2% CH gel had a marked effect in decreasing the % of spirochaetes and, to some
extent, motile bacteria. There was a concomitant shift in colonization to cocci,
fusiform and filamentous organisms in pockets that were irrigated; this coincided
with a reduction in the % of bleeding sites. Various patterns of colonization were
observed which have been described and may assist in differential dark field (DDF)
monitoring of lesions. Bleeding on blunt probing was found to be correlated with a
flora dominated by spirochaetes. No other correlations were found over the 10-week
period between the other parameters.(ABSTRACT TRUNCATED AT 250 WORDS)
AN - rayyan-563561229
AU - Lander, P. E.
AU - Newcomb, G. M.
AU - Seymour, G. J.
AU - Powell, R. N.
DO - 10.1111/j.1600-051x.1986.tb01417.x
IS - 1
KW - Bacteria/classification/*drug effects/isolation & purification
Chlorhexidine/*administration & dosage/pharmacology
Dental Plaque Index
Female
Humans
Male
Periodontal Diseases/drug therapy/*microbiology
Periodontal Index
Therapeutic Irrigation/methods
Time Factors
LA - eng
PY - 1986
SN - 0303-6979 (Print)
SP - 74-80
ST - The antimicrobial and clinical effects of a single subgingival irrigation of
chlorhexidine in advanced periodontal lesions
TI - The antimicrobial and clinical effects of a single subgingival irrigation of
chlorhexidine in advanced periodontal lesions
VL - 13
Y2 - 1
ID - 14603
ER -
TY - JOUR
AN - rayyan-563562007
AU - Lang, N. P.
AU - Anton, E.
AU - Gabriel, Y.
AU - Pjetursson, B. E.
AU - Leslie Winston, J.
AU - He, T.
DO - 10.3290/j.ohpd.a9764
IS - 4
PY - 2004
SP - 369-376
ST - An experimental gingivitis study to evaluate the clinical effects of a
stannous fluoride dentifrice
T2 - Oral Health and Preventive Dentistry
TI - An experimental gingivitis study to evaluate the clinical effects of a
33644631289&doi=10.3290%2fj.ohpd.a9764&partnerID=40&md5=6cc45431d2e3aa5953cd8cfff49
d0de8
VL - 2
ID - 15381
ER -
TY - JOUR
AB - PURPOSE: A double blind, controlled, parallel group trial utilizing the
experimental gingivitis model was performed on thirty young adults to evaluate the
clinical effects of a 0.45% stannous fluoride dentifrice used as a slurry on dental
biofilm formation and the development of gingivitis. MATERIAL AND METHODS:
Following a thorough examination and oral prophylaxis procedures, subjects were
randomly assigned to apply one of the following dentifrices twice daily over a
three-week period: A) dentifrice slurry without active ingredients; B) 0.45%
stannous fluoride gel; and C) Colgate Total dentifrice slurry (0.30% triclosan,
0.24% sodium fluoride, 2% copolymer). RESULTS: After three weeks, the stannous
fluoride dentifrice significantly (p < 0.05) reduced gingivitis compared with the
Colgate Total group by 39.7%. Gingival bleeding was also reduced relative to the
Colgate Total group. This difference was statistically significant (P < 0.05).
During the experimental period, the mean PII scores increased almost linearly in
all three groups without yielding any statistically significant differences.
CONCLUSIONS: The results of this clinical trial demonstrated that, over a three-
week period, the application of a 0.45% SnF2 gel significantly inhibited the onset
of gingivitis compared to Triclosan/sodium fluoride/copolymer (Colgate Total).
However, neither stannous fluoride nor Triclosan/sodium fluoride/ copolymer
(Colgate Total) possessed sufficient antimicrobial activity to suppress biofilm
formation in the absence of regular oral hygiene practices.
AN - rayyan-563560852
AU - Lang, N. P.
AU - Anton, E.
AU - Gabriel, Y.
AU - Salvi, G. E.
AU - Pjetursson, B. E.
AU - Winston, J. L.
AU - He, T.
IS - 4
KW - sodium fluoride plus triclosan
fluoride
tin fluoride
toothpaste
triclosan
adult
article
clinical trial
controlled study
drug mixture
female
gingivitis
human
male
periodontics
tooth plaque
LA - English
PY - 2004
SN - 1602-1622
SP - 369-376
ST - An experimental gingivitis study to evaluate the clinical effects of a
TI - An experimental gingivitis study to evaluate the clinical effects of a
VL - 2
ID - 14226
ER -
TY - JOUR
AB - We report the case of a 3-year-old girl referred to our hospital dentistry
service, from a public health centre, due to a 4-week-old swelling in the area of
the hard palate, causing displacement of the deciduous tooth and the appearance of
an interincisal diastema. The clinical characteristics suggested the possibility of
a reactive fibroma and we decided to intervene surgically by means of an excisional
biopsy. Histology confirmed the presumptive diagnosis. Prompt referral and early
surgical care spontaneously favoured both repositioning of the displaced primary
tooth and closure of the diastema. This is an infrequent lesion in paediatric
patients.
AN - rayyan-563559888
AU - Lapitskaya, A.
AU - Cahuana-Bartra, P.
AU - Brunet-Llobet, L.
AU - Miranda-Rius, J.
DO - 10.1136/bcr-2022-249369
IS - 3
KW - chlorhexidine
gel
hyaluronic acid
paracetamol
acanthosis
article
case report
child
clinical article
crossbite
deciduous tooth
dentistry
diastema
differential diagnosis
disease association
disease duration
electrosurgery
excisional biopsy
female
follow up
general anesthesia
giant cell tumor
histology
human
informed consent
local anesthesia
microscopy
mouth cancer
mouth examination
mouth hygiene
odontogenic fibroma
oral irritation fibroma
ossifying fibroma
palate disease
palate swelling
parakeratosis
patient referral
preschool child
prescription
soft diet
surgical technique
treatment duration
wound healing
LA - English
PY - 2022
SN - 1757-790X
ST - Oral irritation fibroma associated with the pathological migration of a
primary tooth
T2 - BMJ Case Rep.
TI - Oral irritation fibroma associated with the pathological migration of a
primary tooth
VL - 15
ID - 13262
ER -
TY - JOUR
AB - OBJECTIVES Non surgical therapy of peri-im plantitis, despite being believed
the essential first step to resolve the pathology, gives, accordingly to current
literature unaffordable results and very often a subse quent surgical step is
required to control the disease. Various approaches have been proposed but none of
theme seem to be superior or seem to ensure predictable results. The proposed
composite approach, based on the use of a local antibi otic after careful hygienic
proce dures and individual instructions, debridement with specifically de signed
instrument to reach the implant surface and careful bio film elimination with
glycine/eri thritol powders, could result in a better control of the biometric pa
rameters involved in peri-implan titis with their control and reduc tions in
maintainable areas for medium a long terms. Aim of this study was to evaluate the
potentiality of this therapeuti cal approach in patients with at least 1 implant
showing BoP+ and bone loss >2 mm on in tra-oral x-rays. MATERIALS AND METHODS
Twenty-six patients providing 49 implants showing BoP+ and bone loss >2 mm on
intra-oral x-rays taken with parallel technique, were enrolled and underwent: full
mouth supra/sub gingival de bridement, with ultrasonic scalers designed to reach
the implant surface, biofilm removal with gly cine/erithritol powders, individual
oral hygiene instructions and dox ycycline gel application. Biometric parameters,
PPD, BoP, REC, were recorded on six points on each implant at baseline, three and
twelve months. RESULTS Baseline PPD was 6.7 mm, REC = 0.6 mm and BoP 100%. At 1
year values were 4.6 mm, 1.6 mm and 29%, respectively, yet at three months PPD of
4.8, REC of 1.6 mm and BoP of 39% were re corded; 60% of the tested im plants
achieved a PPD ≤4 mm and 56% achieved a PPD ≤4 mm without bleeding; results that
might suggest a decreased need for surgery to treat the residual pathology.
CONCLUSIONS This approach obtained a clinical relevant and statistically signifi
cant PPD reduction, despite a REC increase. Further and more de tailed
investigations are needed to confirm the results and the clinical potentiality of
the protocol of the present investigation and after, through more sophisticated
stud ies to fully understand of the role of the different components of the
approach, in particular the topical antibiotic. CLINICAL SIGNIFICANCE The tested
protocol gave encour aging results and could, if further confirmed, provide a
predictable therapeutic non surgical strategy for peri-implantitis capable of re
ducing the surgical needs.
AN - rayyan-563559854
AU - Latronico, M.
AU - Camurati, A.
AU - Currarino, F.
AU - Giargia, M.
DO - 10.19256/d.cadmos.05.2022.06
IS - 5
KW - intraoral X ray system
tooth implant
ultrasonic scaler
doxycycline
antibiotic therapy
article
bleeding on probing
clinical article
human
mouth hygiene
osteolysis
periimplantitis
LA - Italian
PY - 2022
SN - 0011-8524
SP - 358-366
ST - Non surgical mechanical/pharmacological therapy of peri-implantitis: one year
results
T2 - Terapia non chirurgica, meccanico/ farmacologica della perimplantite:
risultati a un anno
TI - Non surgical mechanical/pharmacological therapy of peri-implantitis: one year
results
VL - 90
ID - 13228
ER -
TY - JOUR
AB - The use of chemical devices for non-surgical periodontal therapy has led to
new treatment strategies aiming primarily at infection control and oral bacterial
load. Over the last few decades adjunctive chemical devices has been subjected to
many scientific and medical studies. The purpose of the present study was to assess
the effect of a new oral gel named Parodongel on the red complex organisms using
Polymerase Chain Reaction (PCR) for microbiological analysis. A total of 10
patients with a diagnosis of chronic periodontitis in the age group >25 years, were
selected. None of these patients had received any surgical or non-surgical
periodontal therapy and demonstrated radiographic evidence of moderate bone loss.
Four non-adjacent sites in separate quadrants were selected in each patient for
monitoring based on criteria that the sites will localize chronic periodontitis.
Microbial analysis (MA) was performed at baseline and at day 15. Paired T-Test was
used to detect statistical significant reduction of specific bacteria. The results
showed statistically significant reduction of the overall bacterial loading and
Treponema Denticola from baseline to day 15. Parodongel can be used as an effective
local drug delivery together with oral home care in treatment of chronic
periodontitis.
AN - rayyan-563560365
AU - Lauritano, D.
AU - Bignozzi, C. A.
AU - Pazzi, D.
AU - Palmieri, A.
AU - Gaudio, R. M.
AU - Di Muzio, M.
AU - Carinci, F.
IS - 2
adult
article
bacterial load
bone radiography
clinical article
gel
groups by age
human
mouth hygiene
osteolysis
Treponema denticola
LA - English
PY - 2016
SN - ["1724-6083", "0393-974X"]
SP - 123-128
ST - Evaluation of the efficacy of a new oral gel as an adjunct to home oral
hygiene in the management of chronic periodontitis. A microbiological study using
PCR analysis
T2 - J. Biol. Regul. Homeostatic Agents
TI - Evaluation of the efficacy of a new oral gel as an adjunct to home oral
hygiene in the management of chronic periodontitis. A microbiological study using
PCR analysis
VL - 30
ID - 13739
ER -
TY - JOUR
AB - Periodontal treatment has the aim to reduce oral infection, and prevent the
progression of the disease. The potential benefits of new chemical devices for
periodontal therapy, include improved patient compliance, an easier access to
periodontal pocket and a lower dosage of antimicrobial agent. The objective of this
study was to explore the efficacy of a chemical device containing zinc and
octenidine in the treatment of chronic periodontitis in adult patients. Ten
patients with a diagnosis of chronic periodontitis (20 localized chronic
periodontitis sites) in the age group of 35 to 55 were selected. None of these
patients received any surgical or non-surgical periodontal therapy and demonstrated
radiographic evidence of moderate bone loss. The chemical device zinc plus
octenedine was used by each patient after daily oral hygiene. Microbial analysis
were analyzed at baseline and on the 15th day. After the treatment, a remarkable
decrease in bacteria amount, both for some species and for the total count was
observed in the study group. Specifically T. forsythia and T. denticola were
eradicated whereas Total Bacteria Loading and Fusobacterium Nucleatum showed a
reduction of 38% and 55%, respectively. Our study demonstrated the efficacy of the
new chemical device containing zinc and octenidine in a sustained release drug
delivery system in the management of moderate to severe chronic periodontitis.
AN - rayyan-563560262
AU - Lauritano, D.
AU - Candotto, V.
AU - Bignozzi, C. A.
AU - Pazzi, D.
AU - Carinci, F.
AU - Cura, F.
AU - Tagliabue, A.
AU - Tettamanti, L.
IS - 2
KW - hydroxypropylcellulose
octenidine
zinc
adult
age
article
bacterial load
clinical article
controlled study
dental radiology
drug efficacy
drug formulation
gel
groups by age
human
mouth hygiene
nonhuman
osteolysis
patient
Treponema denticola
LA - English
PY - 2018
SN - ["1724-6083", "0393-974X"]
SP - 231-236
ST - Zinc plus octenidine: A new formulation for treating periodontal pathogens. A
single blind study
TI - Zinc plus octenidine: A new formulation for treating periodontal pathogens. A
single blind study
VL - 32
ID - 13636
ER -
TY - JOUR
significant reduction in the total bacterial loading evaluated pre- and post-
the ADC gel.
AN - rayyan-563562425
AU - Lauritano, D.
AU - Palmieri, A.
AU - D'Orto, O.
AU - Bolzoni, A.
AU - Ottria, L.
AU - Gargari, M.
AU - Di Girolamo, M.
AU - Candotto, V.
DO - 10.1177/2058738419868101
PY - 2019
SN - ["0394-6320", "2058-7384"]
T2 - INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
VL - 33
Y2 - 10
ID - 15799
ER -
TY - JOUR
AB - The use of chemical devices for domestic oral hygiene in periodontal patients
has led to new treatment strategies aiming primarily at a control of infection.
Over the last few years, carvacrol and thymol (CT) have been subjected to many
scientific and medical studies. The purpose of the present study was to assess the
effect of CT on the red complex bacteria using Polymerase Chain Reaction (PCR) for
microbiological analysis. Five patients with a diagnosis of chronic periodontitis
in the age group >25 years, were selected. None of these patients had received any
surgical or non-surgical periodontal therapy and demonstrated radiographic evidence
of moderate bone loss. After scaling and root planning, patients received a CT gel
to be used at home. Four non-adjacent sites in separate quadrants were selected in
each patient for monitoring, based on criteria that the sites localize chronic
periodontitis. Microbial analysis (MA) was analyzed at baseline and at day 15. SPSS
program was used for statistical purposes and a paired samples correlation was
performed at the end of the observation period. Although an absolute reduction was
observed among the studied bacteria (i.e. Aggregatibacter actinomycetemcomitans,
Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Fusobacterium
nucleatum, Campylobacter rectus and Total bacteria loading) none reach a
statistical significant value. The present study demonstrated that CT gel has a
small impact on oral biofilm. Additional studies are needed to detect the efficacy
of CT gel.
AN - rayyan-563560368
AU - Lauritano, D.
AU - Pazzi, D.
AU - Iapichino, A.
AU - Gaudio, R. M.
AU - Di Muzio, M.
AU - Lo Russo, L.
AU - Pezzetti, F.
IS - 2
KW - carvacrol
povidone
thymol
aqueous solution
article
Candida albicans
clinical article
drug efficacy
Enterococcus hirae
Escherichia coli
gel
home care
human
mouth hygiene
osteolysis
pilot study
surface property
Treponema denticola
LA - English
PY - 2016
SN - 0393-974X
SP - 129-134
ST - Evaluation of the efficacy of a new oral gel containing carvacrol and thymol
for home oral care in the management of chronic periodontitis using PCR analysis: A
microbiological pilot study
TI - Evaluation of the efficacy of a new oral gel containing carvacrol and thymol
VL - 30
ID - 13742
ER -
TY - JOUR
AB - The use of chemical devices for domestic oral hygiene in periodontal patients
has led to new treatment strategies aiming primarily at a control of infection.
Over the last few years, carvacrol and thymol (CT) have been subjected to many
scientific and medical studies. The purpose of the present study was to assess the
effect of CT on the red complex bacteria using Polymerase Chain Reaction (PCR) for
microbiological analysis. Five patients with a diagnosis of chronic periodontitis
in the age group >25 years, were selected. None of these patients had received any
surgical or non-surgical periodontal therapy and demonstrated radiographic evidence
of moderate bone loss. After scaling and root planning, patients received a CT gel
to be used at home. Four non-adjacent sites in separate quadrants were selected in
each patient for monitoring, based on criteria that the sites localize chronic
periodontitis. Microbial analysis (MA) was analyzed at baseline and at day 15. SPSS
program was used for statistical purposes and a paired samples correlation was
performed at the end of the observation period. Although an absolute reduction was
observed among the studied bacteria (i.e. Aggregatibacter actinomycetemcomitans,
Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Fusobacterium
nucleatum, Campylobacter rectus and Total bacteria loading) none reach a
statistical significant value. The present study demonstrated that CT gel has a
small impact on oral biofilm. Additional studies are needed to detect the efficacy
of CT gel.
AN - rayyan-563560364
AU - Lauritano, D.
AU - Pazzi, D.
AU - Iapichino, A.
AU - Gaudio, R. M.
AU - Muzio, M. D. I.
AU - Russo, L. L. O.
AU - Pezzetti, F.
IS - 2
KW - bovine serum albumin
carvacrol
thymol
adult
article
bacterium examination
biofilm
clinical article
clinical evaluation
drug efficacy
fungicidal activity
gel
groups by age
home care
human
infection control
managed care
mouth hygiene
osteolysis
patient monitoring
tooth root canal
treatment planning
Treponema denticola
LA - English
PY - 2016
SN - ["1724-6083", "0393-974X"]
SP - 129-134
ST - Evaluation of the efficacy of a new oral gel containing carvacrol and thymol
TI - Evaluation of the efficacy of a new oral gel containing carvacrol and thymol
VL - 30
ID - 13738
ER -
TY - JOUR
AN - rayyan-563560998
AU - Lawlor, M. S.
AU - Jones, D. S.
IS - 26
KW - gantrez copolymer
povidone
tetracycline
conference paper
flow kinetics
gel
periodontal disease
viscoelasticity
LA - English
PY - 1999
SN - 1022-0178
SP - 1002-1003
ST - Rheological and mechanical characterisation of tetracycline-containing gels
designed for the treatment of periodontal diseases
T2 - Proc. Control. Release Soc.
TI - Rheological and mechanical characterisation of tetracycline-containing gels
designed for the treatment of periodontal diseases
ID - 14372
ER -
TY - JOUR
AB - BACKGROUND: Plaque accumulation and resulting caries or periodontal disease
is a frequent problem in patients with special-care needs. Tray-applied 10 percent
carbamide peroxide (CP) is a tooth-bleaching agent that has positive effects on
plaque, gingival health and caries. METHODS: The authors review the antibacterial
properties of CP and the effects of CP on saliva, plaque, caries and gingival
health. They also review tray fabrication options and techniques, application
methods, safety and side effects. Finally, they address the challenges involved in
and research needed regarding use of tray-applied CP materials in special-care
patients. RESULTS: In their literature review and clinical experience, the authors
found 10 percent CP delivered in a custom-fitted tray to be an effective treatment
for caries in patients with compromised oral hygiene. Plaque suppression and caries
control result from a CP-induced increase in salivary and plaque pH caused by CP's
urea component, and from possible antimicrobial action via physical debridement and
the direct chemical effect of hydrogen peroxide. CONCLUSIONS: Tray-applied 10
percent CP may hold great promise for improving the oral health of many special-
care patients, including elderly patients, patients with cancer and patients with
dry mouth. Further research is needed to verify the potential benefits, specifics
of treatment times and protocols and most cost-effective products for use in
various patient groups. CLINICAL IMPLICATIONS: Application of 10 percent CP in a
custom-fitted tray may reduce caries by elevating the pH above the level at which
the caries process can occur, in addition to debriding the teeth and improving
gingival health.
AN - rayyan-563560644
AU - Lazarchik, D. A.
AU - Haywood, V. B.
IS - 6
carbamide peroxide
gel
peroxide
urea
dental caries
tooth plaque
disabled person
drug effect
gingiva
health
human
mouth hygiene
pH
saliva
LA - English
PY - 2010
SN - 1943-4723
SP - 639-646
ST - Use of tray-applied 10 percent carbamide peroxide gels for improving oral
health in patients with special-care needs
T2 - J Am Dent Assoc
TI - Use of tray-applied 10 percent carbamide peroxide gels for improving oral
VL - 141
ID - 14018
ER -
TY - JOUR
AB - Background. Plaque accumulation and resulting caries or periodontal disease
is a frequent problem in patients with special-care needs. Trayapplied 10 percent
carbamide peroxide (CP) is a tooth-bleaching agent that has positive effects on
plaque, gingival health and caries. Methods. The authors review the antibacterial
properties of CP and the effects of CP on saliva, plaque, caries and gingival
health. They also review tray fabrication options and techniques, application
methods, safety and side effects. Finally, they address the challenges involved in
and research needed regarding use of tray-applied CP materials in special-care
patients. Results. In their literature review and clinical experience, the authors
found 10 percent CP delivered in a custom-fitted tray to be an effective treatment
for caries in patients with compromised oral hygiene. Plaque suppression and caries
control result from a CP-induced increase in salivary and plaque pH caused by CPs
urea component, and from possible antimicrobial action via physical debridement and
the direct chemical effect of hydrogen peroxide. Conclusions. Tray-applied 10
percent CP may hold great promise for improving the oral health of many special-
care patients, including elderly patients, patients with cancer and patients with
dry mouth. Further research is needed to verify the potential benefits, specifics
of treatment times and protocols and most cost-effective products for use in
various patient groups. Clinical Implications. Application of 10 percent CP in a
customfitted tray may reduce caries by elevating the pH above the level at which
the caries process can occur, in addition to debriding the teeth and improving
gingival health.
AN - rayyan-563560639
AU - Lazarchik, D. A.
AU - Van B, H.
DO - 10.14219/jada.archive.2010.0251
IS - 6
drug derivative
peroxide
urea
carbamide peroxide
article
dental caries
disabled person
drug effect
gel
gingiva
health
human
mouth hygiene
pH
saliva
tooth plaque
LA - English
PY - 2010
SN - 0002-8177
SP - 639-646
ST - Use of tray-applied 10 percent carbamide peroxide gels for improving oral
T2 - J. Am. Dent. Assoc.
TI - Use of tray-applied 10 percent carbamide peroxide gels for improving oral
VL - 141
ID - 14013
ER -
TY - JOUR
AB - Implants and prostheses are widely used to replace damaged tissues or to
treat various diseases. However, besides the risk of bacterial or fungal infection,
an inflammatory response usually occurs. Here, recent progress in the field of
anti-inflammatory biomaterials is described. Different materials and approaches are
used to decrease the inflammatory response, including hydrogels, nanoparticles,
implant surface coating by polymers, and a variety of systems for anti-inflammatory
drug delivery. Complex multifunctional systems dealing with inflammation, microbial
infection, bone regeneration, or angiogenesis are also described. New promising
stimuli-responsive systems, such as pH- and temperature-responsive materials, are
also being developed that would enable an “intelligent” antiinflammatory response
when the inflammation occurs. Together, different approaches hold promise for
creation of novel multifunctional smart materials allowing better implant
integration and tissue regeneration.
AN - rayyan-563560034
AU - Lebaudy, E.
AU - Fournel, S.
AU - Lavalle, P.
AU - Vrana, N. E.
AU - Gribova, V.
DO - 10.1002/adhm.202001373
IS - 1
KW - bone implant
film
hip prosthesis
knee prosthesis
surgical mesh
wound dressing
aceclofenac
alginic acid
alpha tocopherol
amfenac
ascorbic acid
benzoic acid
betamethasone
betamethasone dipropionate
biomaterial
carbomer
catestatin
celecoxib
chitosan
chondroitin sulfate
citral
collagen
curcumin
cyclodextrin
dermatan sulfate
dexamethasone
diclofenac
dopamine
fibrin
fucoidin
gelatin
glycyrrhizic acid
heparin
hyaluronic acid
hydrogel
ibuprofen
indometacin
interleukin 1
interleukin 10
interleukin 13
interleukin 1beta
interleukin 4
interleukin 6
interleukin 8
keratin
ketoprofen
levofloxacin
lidocaine
luteolin 7 glucoside
metal nanoparticle
microgel (material)
morin
nanocage
nanocapsule
nanomaterial
nanoparticle
naringenin
nerolidol
pilocarpine
piroxicam
plasmid DNA
polyarginine
polycaprolactone
polyetheretherketone
polyethylene
polyglutamic acid
polylactide
polysaccharide
polystyrene
prednisolone
quercetin
resolvin D1
resveratrol
silk
silver nanoparticle
titanium
unclassified drug
Aloe vera
arthritis
article
biocompatibility
biodegradation
coating (procedure)
cytokine production
dermatitis
drug release
drug solubility
equipment design
foreign body reaction
honey
human
hydrophobicity
immune response
immunomodulation
implantation
inflammation
knee arthritis
macromolecule
macrophage
mouth injury
nanoencapsulation
nanofabrication
nonhuman
periodontitis
physical chemistry
porosity
priority journal
surface property
tissue engineering
tissue regeneration
wound healing
LA - English
PY - 2021
SN - ["2192-2659", "2192-2640"]
ST - Recent Advances in Antiinflammatory Material Design
TI - Recent Advances in Antiinflammatory Material Design
VL - 10
ID - 13408
ER -
TY - JOUR
AB - OBJECTIVE: The aim of this study was to evaluate clinical efficacy of
different chlorhexidine gluconate (CHX) preparations applied subgingivally as an
adjunct to scaling and root planing (SRP). MATERIAL AND METHODS: A total of 120
periodontal pockets was included in this randomized, controlled, split mouth
designed study. According to protocols used in treatment, periodontal pockets were
assigned to experimental and control groups as follows: CHX solution as an addition
to SRP versus control SRP group; CHX gel as an addition to SRP versus control SRP;
CHX chip as an addition to SRP versus control SRP group. Following clinical
parameters were recorded at baseline, one and three months after the baseline:
plaque index (PI), probing pocket depth (PPD), bleeding index (BI) and clinical
attachment level (CAL). RESULTS: The most significant improvements were found
concerning PI in CHX solution with SRP and CHX gel with SRP groups over controls at
one month recall, as well as concerning BI and PPD in CHX chip with SRP group over
SRP alone at three-month recall. CONCLUSION: Results of this study favour
combination therapy using CHX chip as an adjunct to SRP due to greater improvements
in BI and PPD compared to those obtained by SRP alone in the treatment of chronic
periodontitis.
AN - rayyan-563560340
AU - Lecic, J.
AU - Cakic, S.
AU - Janjic Pavlovic, O.
AU - Cicmil, A.
AU - Vukotic, O.
AU - Petrovic, V.
AU - Cicmil, S.
DO - 10.1080/00016357.2016.1206964
IS - 6
KW - chlorhexidine
adult
controlled study
female
human
male
middle aged
periodontal index
periodontal pocket
plaque index
LA - English
PY - 2016
SN - 1502-3850
SP - 502-507
ST - Different methods for subgingival application of chlorhexidine in the
treatment of patients with chronic periodontitis
TI - Different methods for subgingival application of chlorhexidine in the
VL - 74
ID - 13714
ER -
TY - JOUR
AB - Objective: The aim of this study was to evaluate clinical efficacy of
different chlorhexidine gluconate (CHX) preparations applied subgingivally as an
adjunct to scaling and root planing (SRP).Material and methods: A total of 120
periodontal pockets was included in this randomized, controlled, split mouth
designed study. According to protocols used in treatment, periodontal pockets were
assigned to experimental and control groups as follows: CHX solution as an addition
to SRP versus control SRP group; CHX gel as an addition to SRP versus control SRP;
CHX chip as an addition to SRP versus control SRP group. Following clinical
parameters were recorded at baseline, one and three months after the baseline:
plaque index (PI), probing pocket depth (PPD), bleeding index (BI) and clinical
attachment level (CAL).Results: The most significant improvements were found
concerning PI in CHX solution with SRP and CHX gel with SRP groups over controls at
one month recall, as well as concerning BI and PPD in CHX chip with SRP group over
SRP alone at three-month recall.Conclusion: Results of this study favour
combination therapy using CHX chip as an adjunct to SRP due to greater improvements
in BI and PPD compared to those obtained by SRP alone in the treatment of chronic
periodontitis.
AN - rayyan-563562323
AU - Lecic, J.
AU - Cakic, S.
AU - Pavlovic, O. J.
AU - Cicmil, A.
AU - Vukotic, O.
AU - Petrovic, V.
AU - Cicmil, S.
DO - 10.1080/00016357.2016.1206964
IS - 6
PY - 2016
SN - ["0001-6357", "1502-3850"]
SP - 502-507
ST - Different methods for subgingival application of chlorhexidine in the
T2 - ACTA ODONTOLOGICA SCANDINAVICA
TI - Different methods for subgingival application of chlorhexidine in the
VL - 74
ID - 15697
ER -
TY - JOUR
AB - Purpose: To evaluate the influence of a triclosan-polydimethylsiloxane-
containing gel when used as an adjunct to scaling and root planing on the treatment
of chronic periodontal disease. Methods: A 3-month, double-blind, randomized
parallel design clinical trial was performed in 20 subjects with chronic
periodontitis. The subjects, presenting at least three anterior sites with probing
depth (PD) ± 5 mm and bleeding on probing (BoP), were randomly assigned to two
experimental groups: Group SRP-T: scaling/root planing plus test gel application
(triclosan 1% + polydimethylsiloxane 13%) or Group SRP: scaling/root planing plus
control gel application (polydimethylsiloxane 13%). Immediately following
mechanical therapy, each assigned gel was applied to the selected sites and once a
week during the following 3 weeks. Re-examinations were carried out on days 45 and
90 after the last irrigation. Results: Significant reductions in PD and clinical
attachment level (CAL) were observed for both groups in both periods (P< 0.05).
However, SRP-T showed lower means of PD than SRP at Day 45 (3.60 ± 0.87 versus 4.77
± 1.38, respectively, P= 0.035) and CAL at both 45 days (4.63 ± 1.17 versus 6.07 ±
1.43, P= 0.023) and 90 days (4.45 ± 1.19 versus 5.91 ± 1.37, P= 0.021). No
differences were found for bleeding on probing, plaque index and gingival recession
(P> 0.05) between groups.
AN - rayyan-563560702
AU - Lecio, G.
AU - Shaddox, L. M.
AU - Carvalho, M. D.
AU - Duarte, P. M.
AU - Tunes, R. S.
AU - Nogueira-Filho, G. R.
AU - Sallum, E. A.
IS - 3
KW - baysilon
dimeticone
triclosan
adult
article
clinical trial
comparative study
controlled study
female
follow up
gingiva bleeding
gingiva disease
human
male
periodontal disease
periodontal pocket
periodontitis
tooth plaque
LA - English
PY - 2008
SN - 0894-8275
SP - 171-174
ST - Subgingival triclosan-polydimethylsiloxane gel as an adjunct to scaling and
root planing
T2 - Am. J. Dent.
TI - Subgingival triclosan-polydimethylsiloxane gel as an adjunct to scaling and
root planing
VL - 21
ID - 14076
ER -
TY - JOUR
AB - This investigation provides molecular analyses of the periodontal microbiota
in health and disease. Subgingival samples from 47 volunteers with healthy gingivae
or clinically diagnosed chronic periodontitis were characterized by PCR-denaturing
gradient gel electrophoresis (DGGE) with primers specific for the V2-V3 region of
the eubacterial 16S rRNA gene. A hierarchical dendrogram was constructed from band
patterns. All unique PCR amplicons (DGGE bands) were sequenced for identity.
Samples were also analyzed for the presence of Actinobacillus
actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythensis by
multiplex PCR. Associations of patient age, gender, and smoking status together
with the presence of each unique band and putative periodontal pathogens with
disease were assessed by logistic regression. Periodontal pockets were colonized by
complex eubacterial communities (10 to 40 distinct DGGE bands) with substantial
individual variation in the community profile. Species diversity in health and
disease was determined by the Shannon-Weaver index of diversity and compared by the
Mann-Whitney U test. Sequence analyses of DGGE amplicons indicated the occurrence
of many nontypical oral species and eubacteria previously associated with this
environment. With the exception of T. forsythensis, the putative pathogens were not
detected by DGGE. Multiplex PCR, however, detected T. forsythensis, A.
actinomycetemcomitans, and P. gingivalis in 9% 16%, and 29% of the patients with
disease, respectively. The presence of A. actinomycetemcomitans was significantly
associated with disease (P < 0.01). Statistical analyses indicated that the
presence of Treponema socranskii and Pseudomonas sp. was a significant predictor of
disease (P < 0.05) and that there was no significant difference (P > 0.05) in terms
of eubacterial species diversity between health and disease.
AN - rayyan-563562543
AU - Ledder, R. G.
AU - Gilbert, P.
AU - Huws, S. A.
AU - Aarons, L.
AU - Ashley, M. P.
AU - Hull, P. S.
AU - McBain, A. J.
DO - 10.1128/AEM.01419-06
IS - 2
PY - 2007
SN - ["0099-2240", "1098-5336"]
SP - 516-523
ST - Molecular analysis of the subgingival microbiota in health and disease
T2 - APPLIED AND ENVIRONMENTAL MICROBIOLOGY
TI - Molecular analysis of the subgingival microbiota in health and disease
VL - 73
Y2 - 1
ID - 15917
ER -
TY - JOUR
AB - Bacterial biofilm residing in the oral cavity is closely related to the
initiation and persistence of various dental diseases. Previously, we reported the
anti-biofilm activity of Lactobacillus plantarum lipoteichoic acid (Lp.LTA) on a
representative dental cariogenic pathogen, Streptococcus mutans. Since LTA
structure varies in a bacterial strain-specific manner, LTAs from various L.
plantarum strains may have differential anti-biofilm activity due to their distinct
molecular structures. In the present study, we isolated Lp.LTAs from four different
strains of L. plantarum (LRCC 5193, 5194, 5195, and 5310) and compared their anti-
biofilm effects on the dental pathogens, including S. mutans, Enterococcus
faecalis, and Streptococcus gordonii. All Lp.LTAs similarly inhibited E. faecalis
biofilm formation in a dose-dependent manner. However, their effects on S. gordonii
and S. mutans biofilm formation were different: LRCC 5310 Lp.LTA most effectively
suppressed the biofilm formation of all strains of dental pathogens, while Lp.LTAs
from LRCC 5193 and 5194 hardly inhibited or even enhanced the biofilm formation.
Furthermore, LRCC 5310 Lp.LTA dramatically reduced the biofilm formation of the
dental pathogens on the human dentin slice infection model. Collectively, these
results suggest that Lp.LTAs have strain-specific regulatory effects on biofilm
formation of dental pathogens and LRCC 5310 Lp.LTA can be used as an effective
anti-biofilm agent for the prevention of dental infectious diseases.
AN - rayyan-563559941
AU - Lee, D.
AU - Im, J.
AU - Park, D. H.
AU - Jeong, S.
AU - Park, M.
AU - Yoon, S.
AU - Park, J.
AU - Han, S. H.
DO - 10.3389/fmicb.2021.758161
KW - Apreo 2
confocal laser scanning microscope
dialysis membrane
liquid culture
membrane filter
microplate reader
petri dish
spectrophotometer
surgical saw
ultrasonic scaler
ultrasound scanner
VCX500
2 diethylaminoethanol
acetic acid
agar
alcohol
buffer
butanol
cariogenic agent
citrate sodium
crystal violet
distilled water
edetic acid
endotoxin
glucose
glutaraldehyde
glycerol
hydrochloric acid
hypochlorite sodium
immunoglobulin G
lipoteichoic acid
molybdic acid
nitric acid
osmium tetraoxide
paraformaldehyde
peptone
phosphate
polysorbate 20
propanol
propidium iodide
RNA 16S
sepharose
sodium chloride
sodium hydroxide
sodium thiosulfate
stannous chloride
sucrose
sulfuric acid
yeast extract
article
bacterial strain
bacterial viability
biofilm
centrifugation
chemical structure
colony forming unit
dental caries
dentin
dentin slice
gene sequence
gingivitis
hydrophobic interaction chromatography
hydrophobicity
immunoreactivity
incubation time
kimchi
Limulus lysate test
nonhuman
optical density
periodontitis
skim milk
spectrophotometry
staining
tooth flora
tooth plaque
ultrasound
Western blotting
LSM 800
NanoDrop 2000
LA - English
PY - 2021
SN - 1664-302X
ST - Lactobacillus plantarum Lipoteichoic Acids Possess Strain-Specific Regulatory
Effects on the Biofilm Formation of Dental Pathogenic Bacteria
TI - Lactobacillus plantarum Lipoteichoic Acids Possess Strain-Specific Regulatory
Effects on the Biofilm Formation of Dental Pathogenic Bacteria
VL - 12
ID - 13315
ER -
TY - JOUR
AB - The serum protein, alpha 1-proteinase inhibitor (alpha 1-PI), defends the
host against serine proteinases, e.g. PMN elastase. Using a rabbit anti-serum
against human alpha 1-PI, this protein in GCF was quantified from a standard curve
constructed from dot-blot analysis and characterized by Western blot. GCF was
collected on filter paper strips from healthy (H), gingivitis (G) and adult
periodontitis (AP) patients, then extracted with Tris/NaCl/CaCl2 buffer, pH 7.6.
alpha 1-PI concentration increased with G and was highest in AP subjects. H sites
only showed intact alpha 1-PI (52 kDa); no degradation fragments (48 kDa) were
detected. In G and AP subjects, alpha 1-PI degradation fragments were seen in 17%
and 71% of GCF samples, respectively. Both collagenase and alpha 1-PI-degrading
activities in GCF increased with severity of inflammation (GCF flow). Moreover, the
alpha 1-PI degrading (or serpinolytic) activity was characterized as a matrix
metalloproteinase, probably collagenase, based on its in vitro response to a panel
of different proteinase inhibitors including doxycycline. We propose: (1) that
collagenase promotes periodontal breakdown not only by degrading collagen, but also
by depleting alpha 1-PI regulation of elastase and other serine-proteinases,
thereby favoring a broader attack on extracellular matrix (ECM) constituents, and
(2) based on a recent longitudinal double-blind study using the techniques
described above for alpha 1-PI analysis, that low-dose doxycycline administration
to humans with adult periodontitis can inhibit this broad cascade of ECM
degradation.
AN - rayyan-563561050
AU - Lee, H. M.
AU - Golub, L. M.
AU - Chan, D.
AU - Leung, M.
AU - Schroeder, K.
AU - Wolff, M.
AU - Simon, S.
AU - Crout, R.
IS - 1
antiinfective agent
collagenase
doxycycline
leukocyte elastase
trypsin inhibitor
adult
article
enzymology
female
gingivitis
human
immunoblotting
male
metabolism
neutrophil
periodontal disease
LA - English
PY - 1997
SN - 0022-3484
SP - 9-19
ST - alpha 1-Proteinase inhibitor in gingival crevicular fluid of humans with
adult periodontitis: serpinolytic inhibition by doxycycline
TI - alpha 1-Proteinase inhibitor in gingival crevicular fluid of humans with
adult periodontitis: serpinolytic inhibition by doxycycline
VL - 32
ID - 14424
ER -
TY - JOUR
AB - Local delivery agents (LDAs) are widely used in peri-implantitis treatments.
The aim of this study was to identify LDAs remaining on the dental implant surfaces
and to analyze the components of these residues after applying various cleaning
methods. Implants were prepared with a sand-blasted, large-grit, acid-etched
surface. Four kinds of LDAs were applied on the implant surfaces: chlorhexidine gel
(group 2), tetracycline solution (group 3), and 2 kinds of minocycline
hydrochloride agents (groups 4 and 5). Group 1 received normal saline as a control.
Two cleaning methods were applied for different durations as follows: (1) running
distilled water for 10 seconds (subgroup A), 5 minutes (subgroup B), and 15 minutes
(subgroup C); and (2) water spray of a dental-unit chair for 10 seconds (subgroup
D) and 5 minutes (subgroup E). Scanning electron microscopy and energy-dispersive
x-ray spectroscopy were used to analyze the surface morphology and residue
components for all implants. The amount of LDA removed from the implant surfaces in
groups 1, 2, 3, and 5 increased with the cleaning duration and pressure. However,
Minocline remained coated on the implant surfaces in group 4 under all cleaning
conditions. Minocline could not be cleaned off well by water due to its
hydrophobicity. Therefore, directly using this agent on implant surfaces with peri-
implantitis should be carefully considered. The presence of LDA residues without
drug efficacies on implant surfaces might interfere with reosseointegration and act
as a reservoir of microorganisms.
AN - rayyan-563560195
AU - Lee, J. B.
AU - Kweon, H. H. I.
AU - Cho, H. J.
AU - Kim, C. S.
AU - Kim, Y. T.
DO - 10.1563/aaid-joi-D-17-00261
IS - 2
KW - chlorhexidine
human
periimplantitis
surface property
tooth implant
LA - English
PY - 2019
SN - 0160-6972
SP - 116-126
ST - Characteristics of Local Delivery Agents for Treating Peri-Implantitis on
Dental Implant Surfaces: A Preclinical Study
T2 - J Oral Implantol
TI - Characteristics of Local Delivery Agents for Treating Peri-Implantitis on
Dental Implant Surfaces: A Preclinical Study
VL - 45
ID - 13569
ER -
TY - JOUR
AB - Introduction: The aggregation of mixed bacterial flora into sessile biofilms
on root canal surfaces can be one of the causes of persistent apical periodontitis.
The aim of this study was to evaluate the antibacterial efficacy of human beta-
defensin-3 (HBD3) peptide on multispecies biofilms by using confocal laser scanning
microscopy. Methods: Actinomyces naeslundii, Lactobacillus salivarius,
Streptococcus mutans, and Entero coccus faecalis were cultured in a peptone-yeast-
glucose broth, and their culture suspensions were combined in equal proportions.
The mixed bacteria were inoculated on sterile coverslips placed into the wells of
tissue culture plates to permit the formation of mixed species biofilm. After
incubation for 3 weeks, the samples were treated for 24 hours with saline
(control), saturated calcium hydroxide solution (CH), 2% chlorhexidine solution
(CHX), and 50 mu g/mL HBD3 solution. A commercial biofilm/viability assay kit was
used to assess cell viability and analyze the 3-dimensional architecture of
biofilms. The percentage of dead cells was determined from the ratio of biovolumes
for the red subpopulation and the total biofilm. Results: Three medication groups
showed a significant reduction of biovolume within the biofilms compared, with the
control group (P < .001). The HBD3-treated biofilms had a higher percentage of dead
cells than the other medication groups (P < .05). The CH and CHX groups showed
higher levels of bactericidal activity than saline (P < .05), and there was no
significant difference between the 2 groups (P > .05). Conclusions: HBD3 peptide
exhibited more antibacterial activity against mature multispecies biofilms in vitro
than either CH or CHX.
AN - rayyan-563562454
AU - Lee, J. K.
AU - Chang, S. W.
AU - Perinpanayagam, H.
AU - Lim, S. M.
AU - Park, Y. J.
AU - Han, S. H.
AU - Baek, S. H.
AU - Zhu, Q.
AU - Bae, K. S.
AU - Kum, K. Y.
DO - 10.1016/j.joen.2013.07.035
IS - 12
PY - 2013
SN - ["0099-2399", "1878-3554"]
SP - 1625-1629
ST - Antibacterial Efficacy of a Human beta-Defensin-3 Peptide on Multispecies
Biofilms
TI - Antibacterial Efficacy of a Human beta-Defensin-3 Peptide on Multispecies
Biofilms
VL - 39
Y2 - 12
ID - 15828
ER -
TY - JOUR
AB - PURPOSE: Connective tissue reattachment to periodontally damaged root
surfaces is one of the most important goals of periodontal therapy. The aim of this
study was to develop a root conditioning agent that can demineralize and detoxify
the infected root surface. METHODS: Dentin slices obtained from human teeth were
treated with a novel root planing agent for 2 minutes and then washed with
phosphate-buffered saline. Smear layer removal and type I collagen exposure were
observed by scanning electron microscopy (SEM) and type I collagen immunostaining,
respectively. Cell attachment and lipopolysaccharides (LPS) removal demonstrated
the efficiency of the root conditioning agent. RESULTS: SEM revealed that the smear
layer was entirely removed and the dentinal tubules were opened by the experimental
gel. Type I collagen was exposed on the surfaces of the dentin slices treated by
the experimental gel, which were compared with dentin treated with other root
planing agents. Dentin slices treated with the experimental gel showed the highest
number of attached fibroblasts and flattened cell morphology. The agar diffusion
assay demonstrated that the experimental gel also has effective antimicrobial
activity. Escherichia coli LPS were effectively removed from well plates by the
experimental gel. CONCLUSIONS: These results demonstrated that this experimental
gel is a useful tool for root conditioning of infected root surfaces and can also
be applied for detoxification of ailing implant surface threads.
AN - rayyan-563561376
AU - Lee, J. Y.
AU - Seol, Y. J.
AU - Park, J. R.
AU - Park, Y. J.
AU - Chung, C. P.
DO - 10.5051/jpis.2010.40.6.257
IS - 6
J2 - J Periodontal Implant Sci
LA - eng
N1 - Research Institute, Nano Intelligent Biomedical Engineering Corporation
(NIBEC), Seoul, Korea.
PY - 2010
SP - 257-64
ST - Biological effects of a root conditioning agent for dentin surface
modification in vitro
T2 - Journal of periodontal & implant science
TI - Biological effects of a root conditioning agent for dentin surface
modification in vitro
VL - 40
Y2 - 12
ID - 14750
ER -
TY - JOUR
AB - This article presents the results of a controlled clinical trial evaluating a
new at-home treatment to improve gingival health. Designed for overnight
application at the gingival margins and in the interproximal spaces, the product is
a mucoadhesive gel containing 0.10% cetylpyridinium chloride (CPC) and 0.592% zinc
gluconate (ZG). The authors assessed the efficacy and safety of the CPC/ZG gel in
adults with low-to-moderate gingival and plaque index scores by comparing clinical
and laboratory findings for subjects using the CPC/ZG gel with those for subjects
using the control gel (0% CPC and 0.592% ZG). Clinical findings at 3 and 6 months
showed statistically significant improvements in two of the three major indices of
gingival health in the CPC/ZG group compared with the control group. The
performance of the treatment gel was supported by results of microbial analyses of
plaque samples.
AN - rayyan-563560706
AU - Lee, S. S.
AU - Aprecio, R. M.
AU - Zhang, W.
AU - Arambula, M.
AU - Wilkins, K. B.
AU - Stephens, J. A.
AU - Kim, J. S.
AU - Li, Y.
IS - 5
gluconic acid
lithium derivative
zinc
adult
aged
article
clinical trial
comparative study
controlled study
drug effect
female
follow up
gel
gingiva bleeding
gingivitis
Haemophilus
human
male
microbiology
middle aged
periodontics
safety
tooth plaque
treatment outcome
LA - English
PY - 2008
SN - 1548-8578
SP - 302-304, 306, 308 passim
ST - Antiplaque/antigingivitis efficacy and safety of a cetylpyridinium
chloride/zinc gluconate mucoadhesive gel. Results of a 6-month clinical trial
TI - Antiplaque/antigingivitis efficacy and safety of a cetylpyridinium
chloride/zinc gluconate mucoadhesive gel. Results of a 6-month clinical trial
VL - 29
ID - 14080
ER -
TY - JOUR
AB - Aim: We aimed to identify a key molecule that maintains periodontal tissue
homeostasis during biophysical force-induced tooth movement (BTM) by orchestrating
alveolar bone (AB) remodelling. Materials and Methods: Differential display-PCR was
performed to identify key molecules for BTM in rats. To investigate the
localization and expression of the identified molecules, immunofluorescence, real-
time RT-PCR and Western blotting were performed in rats and human periodontal
ligament (PDL) cells. Functional test and micro-CT analysis were performed to
examine the in vivo effects of the identified molecules on BTM. Results: Secretory
leucocyte peptidase inhibitor (SLPI) in the PDL was revealed as a key molecule for
BTM-induced AB remodelling. SLPI was enhanced in the PDL under both compression and
tension, and downregulated by an adenyl cyclases inhibitor. SLPI induced
osteoblastogenic genes including runt-related transcription factor 2 (Runx2) and
synergistically augmented tension-induced Runx2 expression. SLPI augmented
mineralization in PDL cells. SLPI induced osteoclastogenic genes including receptor
activator of nuclear factor kappa-Β ligand (RANKL) and synergistically augmented
the compression-induced RANKL and macrophage colony-stimulating factor (MCSF)
expression. Finally, the in vivo SLPI application into the AB significantly
augmented BTM. Conclusions: SLPI or its inhibitors might serve as a biological
target molecule for therapeutic interventions to modulate BTM.
AN - rayyan-563560001
AU - Lee, S. Y.
AU - Moon, J. S.
AU - Yang, D. W.
AU - Yoo, H. I.
AU - Jung, J. Y.
AU - Kim, O. S.
AU - Kim, M. S.
AU - Koh, J. T.
AU - Chung, H. J.
AU - Kim, S. H.
DO - 10.1111/jcpe.13416
IS - 4
KW - GeneFishing
Lionheart FX
adenylate cyclase
bone sialoprotein
collagen type 1
dexamethasone
hydrogel
interleukin 1beta
interleukin 6
interleukin 8
lipofectamine 2000
lipopolysaccharide
osteoprotegerin
secretory leukocyte proteinase inhibitor
alveolar ridge
animal cell
animal experiment
animal model
apoptosis
article
bone remodeling
cell proliferation
controlled study
Escherichia coli
gene expression
gene silencing
homeostasis
human
immunofluorescence
immunoreactivity
macrophage
mineralization
nonhuman
osteoblast
osteoclast
osteoclastogenesis
periodontal disease
periodontitis
protein expression
rat
RNA extraction
ubiquitination
Western blotting
LA - English
PY - 2021
SN - ["1600-051X", "0303-6979"]
SP - 528-540
ST - SLPI in periodontal Ligament is not sleepy during biophysical force-induced
tooth movement
TI - SLPI in periodontal Ligament is not sleepy during biophysical force-induced
tooth movement
VL - 48
ID - 13375
ER -
TY - JOUR
AB - Chlorhexidine (CHX) is an effective antibacterial agent and is used in dental
treatment in several formulations. The aim of this study was to compare the
effectiveness of CHX solution and CHX gel on dental plaque inhibition and
gingivitis relief by a randomized clinical trial. Thirty-eight participants were
randomly divided into two groups: control group (0.12% CHX solution) and test group
(1% CHX gel). Participants were provided with CHX products and were instructed to
use each product in the morning and evening for 1 week. Clinical results were
evaluated by analyzing the collected data of Turesky et al. the modified Quigley-
Hein Plaque Index (TQHPI), gingival index (GI) and the BANA test. Measurements were
conducted 4 weeks and 8 weeks after using chlorhexidine products. The results were
analyzed using repeated measured ANOVA and paired t-test. TQHPI and GI were
significantly different after treatments in both groups (p < 0.001). The GI
decreased more in the test group compared to the control group 4 weeks and 8 weeks
later. In both groups, the BANA score also significantly decreased (p < 0.001)
after 8 weeks, though the BANA score decreased relatively more in the CHX gel group
than the CHX solution group. These results suggest that 1% CHX gel is more
effective in reducing gingivitis and bacteria of periodontal disease than the 0.12%
CHX solution. Therefore, the 1% CHX gel is expected to be actively used for non-
surgical treatment of periodontal disease patients.
AN - rayyan-563559815
AU - Lee, S. Y.
AU - Nam, E. J.
DO - 10.3390/ijerph19159358
IS - 15
KW - BANA-Enzymatic test
diagnostic kit
adult
article
BANA test
clinical article
controlled study
dental disease assessment
drug efficacy
female
gingival index
gingivitis
human
male
middle aged
Quigley Hein Plaque Index
tooth plaque
LA - English
PY - 2022
SN - ["1660-4601", "1661-7827"]
ST - Clinical Efficacy of 1% CHX Gluconate Gel and 0.12% CHX Solution: A
Randomized Controlled Trial
TI - Clinical Efficacy of 1% CHX Gluconate Gel and 0.12% CHX Solution: A
Randomized Controlled Trial
VL - 19
ID - 13189
ER -
TY - JOUR
AB - Self-assembling peptides are biomedical materials with unique structures that
are formed in response to various environmental conditions. Governed by their
physicochemical characteristics, the peptides can form a variety of structures with
greater reactivity than conventional non-biological materials. The structural
divergence of self-assembling peptides allows for various functional possibilities;
when assembled, they can be used as scaffolds for cell and tissue regeneration, and
vehicles for drug delivery, conferring controlled release, stability, and
targeting, and avoiding side effects of drugs. These peptides can also be used as
drugs themselves. In this review, we describe the basic structure and
characteristics of self-assembling peptides and the various factors that affect the
formation of peptide-based structures. We also summarize the applications of self-
assembling peptides in the treatment of various diseases, including cancer.
Furthermore, the in-cell self-assembly of peptides, termed reverse self-assembly,
is discussed as a novel paradigm for self-assembling peptide-based nanovehicles and
nanomedicines.
AN - rayyan-563560167
AU - Lee, S.
AU - Trinh, T. H. T.
AU - Yoo, M.
AU - Shin, J.
AU - Lee, H.
AU - Kim, J.
AU - Hwang, E.
AU - Lim, Y. B.
AU - Ryou, C.
DO - 10.3390/ijms20235850
IS - 23
KW - alkyl group
amphophile
antimicrobial cationic peptide
bolaamphiphilic peptide
carbon nanotube
cell surface protein
cyclopeptide
dipeptide
gentamicin
ionic complementary self assembling peptide
nanofiber
nanomaterial
nanoparticle
nanotape
nanotube
nanowire
peptide
phenylalanine
phenylalanine derivative
self assembling peptide
surfactant
unclassified drug
alpha helix
cytotoxicity
diseases
human
hydrogel
hydrogen bond
hydrophobicity
meningitis
nerve regeneration
nonhuman
pH
protein conformation
protein structure
review
static electricity
temperature
wound healing
LA - English
PY - 2019
SN - ["1422-0067", "1661-6596"]
ST - Self-assembling peptides and their application in the treatment of diseases
TI - Self-assembling peptides and their application in the treatment of diseases
VL - 20
ID - 13541
ER -
TY - JOUR
AB - Background: Long-acting injectable formulations (LAIFs) have received
substantial attention recently due to their advantages over conventional
formulations, including easy administration, continuous and controlled release of
drug over months, and the ability to maintain drug concentrations within the
therapeutic range. The constant advances in biotechnology produce complex active
pharmaceuticals that might be difficult to administer by conventional means. In
particular, peptides, proteins, and antibodies are hard to administer orally given
their physicochemical instability in the gastrointestinal tract and short half
lives in blood. Therefore, LAIFs are a good candidate delivery system for such
drugs. LAIFs reduce the frequency of application and improve patient compliance.
For instance, LAIF-based antipsychotics can be more effective in patients with
bipolar disorder and schizoaffective disorder. Area covered: This review provides
an overview of the various drug delivery technologies using LAIFs. Poly (lactic-co-
glycolic acid) microspheres, hydrogels, organogels, and liquid crystals were chosen
as representative LAIFs, and their preparation methods, advantages, limitations,
challenges, and prospects are discussed. Expert opinion: LAIFs are an attractive
delivery system for bio-macromolecules that might participate in the new drug
paradigm in the future. While each LAIF-based delivery technology has its own
unique advantages, there are still some limitations that need to be overcome, and
studies are being performed to understand and address these limitations.
AN - rayyan-563560185
AU - Lee, W. Y.
AU - Asadujjaman, M.
AU - Jee, J. P.
DO - 10.1007/s40005-019-00449-9
IS - 4
KW - angiopeptin
buserelin acetate
exendin 4
goserelin
growth hormone
leuprorelin
long acting drug
microsphere
minocycline
naltrexone
octreotide
polycarbonate
polyester
polyglactin
risperidal
risperidone
triptorelin
acromegaly
alcoholism
bipolar disorder
drug absorption
drug formulation
drug synthesis
electrospray
emulsion
growth hormone deficiency
human
hydrogel
liquid crystal
macromolecule
microfluidics
periodontal disease
physical chemistry
priority journal
prostate cancer
review
schizoaffective psychosis
spray drying
arestin
bydureon
consta
decapeptyl
lupron
nutropin
pamorelin
sandostatin
somatuline
suprecur
trelstar
vivitrol
zoladex
LA - English
PY - 2019
SN - ["2093-6214", "2093-5552"]
SP - 459-476
ST - Long acting injectable formulations: the state of the arts and challenges of
poly(lactic-co-glycolic acid) microsphere, hydrogel, organogel and liquid crystal
T2 - J. Pharma. Invest.
TI - Long acting injectable formulations: the state of the arts and challenges of
poly(lactic-co-glycolic acid) microsphere, hydrogel, organogel and liquid crystal
VL - 49
ID - 13559
ER -
TY - JOUR
AB - Background: Compressive force is an important mechanical stimulus on the
periodontal ligament (PDL) and is closely related to therapeutic tooth movement. In
this study, early or late response genes related to the compressive stress in PDL
cells were evaluated. Particularly, the expression of interleukin (IL)-6, IL-8, and
alkaline phosphatase (ALP) was studied. Methods: The primary cultured cells from
PDL were grown in a three-dimensional collagen gel, and received a continuous
static compressive force (1.76 g/cm2). The expressed genes were screened by cDNA
microarray assays for 2 or 12 hours after the initiation of the mechanical force
application. The genes of interest that showed significant changes in expression in
the cDNA microarray assay were analyzed further by quantitative reverse
transcriptase polymerase chain reaction (RT-PCR), enzyme-linked immunoabsorbent
assays (ELISA), and ALP assays. Results: ALP, IL-6, and IL-8 were selected among
the genes that significantly changed expression (/M/ >0.7) and subsequently were
confirmed by quantitative RT-PCR. The secreted protein concentrations for IL-6, IL-
8, and ALP activity were measured at 72 hours after application of continuous
static compressive force. The protein level of IL-6 was significantly increased at
72 hours (P<0.001), but there was no significant change in IL-8 (P>0.05). ALP
activity was decreased ∼41.5% compared to the control (P = 0.015). Conclusions:
Considering that IL-6 is a potent osteoclast activator and the compressive side of
PDL during orthodontic tooth movement shows the resorption of calcified tissue, the
changed expression of IL-6 and ALP in response to the static compressive force in
PDL cells may contribute to the orthodontic tooth movement or alveolar bone
remodeling.
AN - rayyan-563560751
AU - Lee, Y. H.
AU - Nahm, D. S.
AU - Jung, Y. K.
AU - Choi, J. Y.
AU - Kim, S. G.
AU - Cho, M.
AU - Kim, M. H.
AU - Chae, C. H.
DO - 10.1902/jop.2007.060240
IS - 3
interleukin 6
interleukin 8
article
biosynthesis
bone remodeling
cell culture
cytology
dental procedure
DNA microarray
gene expression
genetics
human
metabolism
physiology
LA - English
PY - 2007
SN - 0022-3492
SP - 446-452
ST - Differential gene expression of periodontal ligament cells after loading of
static compressive force
TI - Differential gene expression of periodontal ligament cells after loading of
static compressive force
VL - 78
ID - 14125
ER -
TY - JOUR
AN - rayyan-563561482
AU - Lee, Y.
AU - Gou, Y.
AU - Pan, X.
AU - Gu, Z.
AU - Xie, H.
DO - 10.1016/j.smaim.2023.02.001
PY - 2023
SP - 460-467
ST - Advances of multifunctional hydrogels for periodontal disease
T2 - Smart Materials in Medicine
TI - Advances of multifunctional hydrogels for periodontal disease
85148035330&doi=10.1016%2fj.smaim.2023.02.001&partnerID=40&md5=ef668c39f85202acc143
fbd27fec74b0
VL - 4
ID - 14856
ER -
TY - JOUR
AB - Background: Because of high affinity to the titanium implant surface,
Staphylococcus aureus (S. aureus) has been reported as key microorganism that cause
the peri-implantitis, even though it is not the typical periodontal pathogenic
bacterial strain. The aim of this study was to evaluate the antibacterial property
of the aPDT device, using blue high-power LED light activated flavin
mononucleotide, comparing to the previously proven aPDT method using methylene blue
and red laser on S. aureus biofilm. Methods: Commercial pure titanium grade 4
modified surface with SLA were used to form S. aureus biofilm for 48 h. Two aPDT
systems were used in this study; 1) HELBO®Blue Photosensitizer (Bredent medical),
which is methylene blue (MB) activated by 670-nm red diode laser and 2) FotoSan®
Blue agent Gel (CMS Dental), which contains flavin mononucleotide (FMN) activated
by FotoSan® BLUE LAD (Light Activated Disinfection) light. The antibacterial tests
were performed by total viable count, crystal violet assay, and direct observation
methods. Results: Using the light activated-PS, the log reduction in CFU/mL
compared to non-treatment was 1.23 ± 0.19 log10 and 1.23 ± 0.12 log10 (about 93 %
of reduction) for MB and FMN, respectively. The significant difference in the
reduction could be determined when comparing with using only light (p < 0.01).
Regarding two aPDT systems, the decrease in amount of bacteria after treatment was
not significantly different (p > 0.05). Conclusion: The antibacterial activities of
aPDT using blue high-power LED light activated flavin mononucleotide on S. aureus
biofilm was comparable to those of previous research supporting aPDT using
photoactivated MB.
AN - rayyan-563560096
AU - Leelanarathiwat, K.
AU - Katsuta, Y.
AU - Katsuragi, H.
AU - Watanabe, F.
DO - 10.1016/j.pdpdt.2020.101855
KW - diode laser
light emitting diode
photodynamic therapy device
crystal violet
flavine mononucleotide
methylene blue
titanium
article
bacterial strain
biofilm
nonhuman
priority journal
surface property
viable cell count
FotoSan
HELBO
LA - English
PY - 2020
SN - ["1873-1597", "1572-1000"]
ST - Antibacterial activity of blue high-power light-emitting diode-activated
flavin mononucleotide against Staphylococcus aureus biofilm on a sandblasted and
etched surface
TI - Antibacterial activity of blue high-power light-emitting diode-activated
flavin mononucleotide against Staphylococcus aureus biofilm on a sandblasted and
etched surface
VL - 31
ID - 13470
ER -
TY - JOUR
AB - Background: Bacterial plaque accumulation at the dentogingival junction and
in periodontal pockets is the major etiologic factor in all manifestations of
periodontal disease. The aim of this study was to evaluate whether a locally
delivered 25% metronidazole gel after scaling and root planing (SRP) would enhance
the treatment outcome over SRP alone in periodontal pockets with symptoms of
recurring chronic inflammation. Methods: Twenty-one maintenance-care patients, 10
men and 11 women, having at least one pair of contralateral anatomically matching
proximal tooth surfaces showing probing depth ≥5 mm and bleeding on probing (BOP),
were included in the study. The sites were randomized to be treated with SRP plus
25% metronidazole gel (test sites) or with SRP alone (control sites) in a split-
mouth design. Clinical evaluations were performed immediately pretreatment
(baseline) and at 3 and 6 months post-treatment. Results: Both treatments yielded a
statistically significant (P = 0.001) reduction in probing depth (1.9 and 1.8 mm),
gain of attachment level (1.6 and 1.0 mm), and reduction of BOP (38.1% and 33.3%)
for test and control sites, respectively, at 6 months. There was no statistically
significant difference between the treatments for any of the clinical parameters.
Conclusion: This study indicates that a locally applied 25% metronidazole gel does
not improve the treatment outcome over SRP alone in sites with recurring chronic
inflammation in maintenance-care patients.
AN - rayyan-563560742
AU - Leiknes, T.
AU - Leknes, K. N.
AU - Böe, O. E.
AU - Skavland, R. J.
AU - Lie, T.
DO - 10.1902/jop.2007.060501
IS - 8
metronidazole
adult
aged
article
chronic disease
clinical trial
comparative study
controlled study
female
follow up
gel
gingiva bleeding
human
male
middle aged
periodontal disease
periodontitis
recurrent disease
treatment outcome
LA - English
PY - 2007
SN - 0022-3492
SP - 1538-1544
ST - Topical use of a metronidazole gel in the treatment of sites With symptoms of
recurring chronic inflammation
TI - Topical use of a metronidazole gel in the treatment of sites With symptoms of
recurring chronic inflammation
VL - 78
ID - 14116
ER -
TY - JOUR
AB - Traumatic oral ulceration (TOU) is one of the most common side effects of
orthodontic treatments. The objective of this trial is to compare the clinical
efficacy of an 80% Aloe Vera gel, prepared using a master formula, versus a
commercial 0.12% Chlorhexidine (CHX) gel for TOU prevention in participants wearing
fixed orthodontic appliances. This report represents a single-centre, university-
based, double-blinded, randomized controlled trial with 2 parallel arms. Patients
aged 12 years or older, in the permanent dentition, and about to start fixed
orthodontic treatment in this university setting were randomly allocated to use
either Aloe Vera or CHX gel, following the cementation procedure. Pre-treatment and
1 month after the cementation clinical assessment and digital photographic images
were taken of the teeth and assessed by 2 clinical assessors for the presence or
absence of TOUs. A total of 140 were randomized and completed the trial. The
overall prevalence of TOUs was 43.6%. Overall 5.7% of patients treated with Aloe
Vera gel showed did not suffer from TOUs, whereas in the CHX arm, a total of 57
(81.4%) were affected by this outcome reaching a significant result (p < 0.001). In
terms of relative risk (RRs) and confidence intervals (CIs), Aloe Vera provided
better results than CHX with an RR of 0.07 (95%CI 0.03-0.16; p < 0.001), and with a
patients' number needed to treat of 1.3 (95%CI 1.16-1.54). There were no adverse
effects. These results suggest that Aloe Vera gel administration in patients with
fixed orthodontic appliances could be important for effective prevention of TOU.
AN - rayyan-563560117
AU - Leiva-Cala, C.
AU - Lorenzo-Pouso, A. I.
AU - Centenera-Centenera, B.
AU - López-Palafox, J.
AU - Gándara-Vila, P.
AU - García-García, A.
AU - Pérez-Sayáns, M.
DO - 10.1007/s10266-019-00468-w
IS - 3
KW - Aloe vera gel
chlorhexidine
Aloe
child
controlled study
human
treatment outcome
ulcer
LA - English
PY - 2020
SN - 1618-1255
SP - 470-478
ST - Clinical efficacy of an Aloe Vera gel versus a 0.12% chlorhexidine gel in
preventing traumatic ulcers in patients with fixed orthodontic appliances: a
double-blind randomized clinical trial
T2 - Odontology
TI - Clinical efficacy of an Aloe Vera gel versus a 0.12% chlorhexidine gel in
preventing traumatic ulcers in patients with fixed orthodontic appliances: a
double-blind randomized clinical trial
VL - 108
ID - 13491
ER -
TY - JOUR
AB - In this study we first evaluated the effects of hydrogen peroxide (H2O2) on
growth and selected properties of Porphyromonas gingivalis, and compared them with
those obtained by a reducing agent (cysteine). The growth of P. gingivalis was only
moderately affected when H2O2 was added at concentrations up to 30 mM in a complex
culture medium. However, when a defined basal medium was used, H2O2 at a
concentration of 3 mM completely inhibited growth of P. gingivalis. Incorporation
of cysteine at concentrations up to 30 mM in both media had no effect on growth.
The effects of H2O2 and cysteine on cell-associated hemagglutinating and Arg-
gingipain activities were evaluated using bacteria grown in the complex culture
medium. Both activities were strongly decreased when H2O2 was added in the assay
mixtures. This inhibitory effect of H2O2 was reversible. On the other hand,
including cysteine in the assay mixtures increased both activities. H2O2 and
cysteine had no effect on the expression of heat shock protein (HSP)-68 and HSP-75
by P. gingivalis, as determined by SDS-PAGE and Western immunoblotting analysis. In
the second part of the study, we tested whether growth of selected oral bacterial
species may modify the oxidation-reduction potential (Eh) of the environment. It
was found that certain species were able to either decrease (P. gingivalis,
Fusobacterium nucleatum, Peptostreptococcus micros, Streptococcus mutans) or
increase (Streptococcus sanguis) the Eh of the medium. Our study provides evidence
that an oxidizing agent such as H2O2 may affect the biology of P. gingivalis.
Moreover, growth of some members of the oral microflora can generate oxidizing and
reducing conditions, and thus potentially influence the ecology of subgingival
sites by affecting strictly anaerobic bacteria such as P. gingivalis. Copyright (C)
1999 Federation of European Microbiological Societies.
AN - rayyan-563561007
AU - Leke, N.
AU - Grenier, D.
AU - Goldner, M.
AU - Mayrand, D.
DO - 10.1016/S0378-1097(99)00165-2
IS - 2
KW - cysteine
heat shock protein
hydrogen peroxide
article
bacterial growth
bacterial virulence
hemagglutination
host resistance
human
periodontitis
priority journal
Western blotting
LA - English
PY - 1999
SN - 0378-1097
SP - 347-353
ST - Effects of hydrogen peroxide on growth and selected properties of
TI - Effects of hydrogen peroxide on growth and selected properties of
VL - 174
ID - 14381
ER -
TY - JOUR
AB - The microvascular changes caused by disorders of host immune response to oral
microorganisms resulting in long-lasting inflammation of gums play a critical role
in the periodontal lesion in the pathogenesis of chronic periodontitis. Current
strategies of non-surgical periodontal therapy are aimed at the attainment of
antiinflammatory effects. We hypothesized that the usage of the microencapsulated
form of anti-inflammatory substances with vasoactive effects could enhance the
efficiency of the therapy by the prolonged release of active components. The
prepared suspension of silver-alginate microcapsules loaded with tannic acid in the
hydrogel was applied in vivo to the experimental model of periodontitis in rats
induced by a ligature. The effect of this formulation was assessed by monitoring
changes in local microcirculation performed by the Laser Doppler Flowmetry (1 and
24 h after application of hydrogel on intact gums and 21-days after the start of
periodontitis' modeling). Application of the hydrogel containing multicomponent
microcapsules to the affected area of gums allows correction of inflammatory
microcirculatory disorders in model periodontitis. Immobilization of tannic acid
into microcapsules allows increasing the correction of the following parameters:
perfusion disorders, neurogenic tone of arterioles, myogenic tone of precapillary
sphincters, as well as a venous outflow in the microvasculature of the gums. The
hydrogel containing multicomponent microcapsules reduces the vascular inflammatory
response in the model of periodontitis. Loading of silver-alginate microcapsules
with tannic acid enhances the efficiency of microvascular disorders' correction in
the model of periodontitis that suggests the prospects for application of this drug
delivery system for non-surgical treatment of periodontitis.
AN - rayyan-563562238
AU - Lengert, E. V.
AU - Savkina, A. A.
AU - Ermakov, A. V.
AU - Saveleva, M. S.
AU - Lagutina, D. D.
AU - Stepanova, T. V.
AU - Ivanov, A. N.
DO - 10.1016/j.msec.2021.112144
PY - 2021
SN - ["0928-4931", "1873-0191"]
ST - Influence of the new formulation based on silver alginate microcapsules
loaded with tannic acid on the microcirculation of the experimental periodontitis
in rats
T2 - MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
TI - Influence of the new formulation based on silver alginate microcapsules
loaded with tannic acid on the microcirculation of the experimental periodontitis
in rats
VL - 126
Y2 - 7
ID - 15612
ER -
TY - JOUR
AB - The antimicrobial activity of irrigating solutions-Endoquil (castor oil
detergent), 2% chlorhexidine gluconate solution, and 0.5% NaOCl solution-was
evaluated against Gram-positive cocci (Micrococcus luteus, Staphylococcus aureus,
Enterococcus faecalis, Staphylococcus epidermidis, Streptococcus mutans, and
Streptococcus sobrinus), Gramnegative rods (Escherichia coli and Pseudomonas
aeruginosa), and the yeast Candida albicans. Activity was evaluated using the two-
layer agar diffusion technique. The base layer was obtained by pouring 10.0 ml of
Muller Hinton Medium or 10.0 ml of Brain Heart Infusion agar in a Petri dish. After
solidification a 5.0 ml seed layer of Muller Hinton Medium or Brain Heart Infusion
agar with inoculum (10(6)/ml) was added. Absorbent paper disks (6.0 mm in diameter)
immersed in the solutions were placed at equidistant points. Plates were maintained
at room temperature for 2 h for prediffusion of the solutions and incubated at 37
degreesC for 24 h. The candle jar system was used for the Brain Heart Infusion agar
plates. All tests were performed in duplicate. After incubation the medium was
optimized with 0.05 g% triphenyltetrazolium chlorate gel and inhibition halos were
measured. All bacterial strains were inhibited by 2.0% chlorhexidine gluconate.
Endoquil was effective against Grampositive microorganisms, and 0.5% NaOCl was
effective only against S. aureus.
AN - rayyan-563562537
AU - Leonardo, M. R.
AU - da Silva, L. A. B.
AU - Tanomaru, M.
AU - Bonifacio, K. C.
AU - Ito, I. Y.
IS - 12
PY - 2001
SN - 0099-2399
SP - 717-719
ST - In vitro evaluation of the antimicrobial activity of a castor oil-based
irrigant
TI - In vitro evaluation of the antimicrobial activity of a castor oil-based
irrigant
VL - 27
Y2 - 12
ID - 15911
ER -
TY - JOUR
AB - Given its safety and apparent low aqueous solubility, borneol may serve as a
matrix forming component of anti-solvent based in situ forming matrixes (ISMs) for
crevicular pocket targeting. Drug-free and vancomycin hydrochloride-loaded borneol
ISMs were evaluated for pH, density, viscosity, contact angle, surface tension,
matrix formation, drug release behavior, in vitro degradability and antimicrobial
activities. Density and pH values of borneol-based ISMs decreased with increasing
borneol concentration. Given their markedly low viscosity could facilitate better
injectability. The contact angles of the drug-free and vancomycin HCl-loaded
borneol ISMs increased after being in contact with the agarose gel or the bulge
tissue of porcine due to phase inversion. A dense borneol crystal matrix formed
after using the highly concentrated ISM corresponded to fast matrix formation. The
borneol-based ISM exhibited a sustainable drug release longer than 14 days with a
diffusion-controlled release mechanism. Moreover, the developed ISM exhibited
strong antimicrobial activities against various microbes. Thus, the vancomycin HCl-
loaded borneol-based ISM is a potentially effective local anti-solvent-based ISM
for periodontitis treatment via crevicular pocket injection.
AN - rayyan-563559866
AU - Lertsuphotvanit, N.
AU - Santimaleeworagun, W.
AU - Narakornwit, W.
AU - Chuenbarn, T.
AU - Mahadlek, J.
AU - Chantadee, T.
AU - Phaechamud, T.
DO - 10.1016/j.ijpharm.2022.121603
KW - flowmeter
goniometer
microscope
stereoscope
borneol
doxorubicin
vancomycin
alkalinity
article
Candida albicans
contact angle
crevicular pocket
crystallization
dialysis
drug release
Escherichia coli
gingiva
glioblastoma
human
in vitro study
mouth cavity
nonhuman
parameters
periodontitis
pH
porosity
room temperature
sedimentation
shear rate
shear stress
surface tension
thermodynamics
tooth plaque
viscosity
water solubility
wettability
zone of inhibition
LA - English
PY - 2022
SN - ["1873-3476", "0378-5173"]
ST - Borneol-based antisolvent-induced in situ forming matrix for crevicular
pocket delivery of vancomycin hydrochloride
T2 - Int. J. Pharm.
TI - Borneol-based antisolvent-induced in situ forming matrix for crevicular
pocket delivery of vancomycin hydrochloride
VL - 617
ID - 13240
ER -
TY - JOUR
AB - As an alternative to the traditional polymeric-based system, it is now
possible to use an in situ forming system that is based on small molecules. Borneol
was used as matrix formation in this study. While triacetin was incorporated into
the formulation for prolonging the drug release. The objective of this study is to
understand the initial period of the solvent exchange mechanism at the molecular
level, which would provide a basis for explaining the matrix formation and drug
release phenomena. The evaluation of basic physical properties, matrix formation,
in vitro drug release, and molecular dynamics (MD) simulation of borneol-based in
situ forming matrixes (ISM) was conducted in this study. The proportion of
triacetin was found to determine the increase in density and viscosity. The density
value was found to be related to viscosity which could be used for the purpose of
prediction. Slow self-assembly of ISM upon the addition of triacetin was associated
with higher viscosity and lower surface tension. This phenomenon enabled the
regulation of solvent exchange and led to sustaining the drug release. In MD
simulation using AMBER Tools, the free movement of the drug and the rapid approach
to equilibrium of both solvent and water molecule in a solvent exchange mechanism
in borneol-free ISM was observed, supporting that sustained release would not
occur. Water infiltration was slowed down and NMP movement was restricted by the
addition of borneol and triacetin. In addition, the increased proportion of
triacetin promoted the diminished down of all substances’ movement because of the
viscosity. The diffusion constant of relevant molecules decreased with the addition
of borneol and/or triacetin. Although the addition of triacetin tended to slow down
the solvent exchange and molecular movement from computation modelling results, it
may not guarantee to imply the best drug release control. The Low triacetin-
incorporated (5%) borneol-based ISM showed the highest ability to sustain the drug
release due to its self-assembly and has proper solvent exchange. MD simulation
addressed the details of the mechanism at the beginning of the process. Therefore,
both MD and classical methods contribute to a clearer understanding of solvent
exchange from the molecular to macroscopic level and from the first nanosecond of
the formulation contact with water to the 10-day of drug release. These would be
beneficial for subsequent research and development efforts in small molecule-based
in situ forming systems.
AN - rayyan-563559689
AU - Sirirak, J.
AU - Tamdee, P.
AU - Phaechamud, T.
AU - Chantadee, T.
IS - 8
KW - data analysis software
densitometer
flowmeter
goniometer
microscope
borneol
doxycycline
hydrogel
solvent
terpene
triacetin
article
computer simulation
controlled study
crystallization
diffusion
diffusion coefficient
drug diffusion
drug formulation
drug release
emulsion
human
hydrogen bond
hydrophobicity
in situ forming matrix
in vitro study
molecular dynamics
periodontal pocket
shear rate
shear stress
simulation
surface tension
thermodynamics
viscosity
LA - English
PY - 2023
SN - 1999-4923
ST - Ways to Assess and Regulate the Performance of a Bi-Mechanism-Induced
Borneol-Based In Situ Forming Matrix
T2 - Pharmaceutics
TI - Ways to Assess and Regulate the Performance of a Bi-Mechanism-Induced
Borneol-Based In Situ Forming Matrix
VL - 15
ID - 13063
ER -
TY - JOUR
AB - Borneol has been successfully employed as a gelling agent for in situ forming
gel (ISG). While 40% borneol can regulate drug release, there is interest in novel
approaches to achieve extended drug release, particularly through the incorporation
of hydrophobic substances. Herein, triacetin was selected as a hydrophobic additive
solvent for doxycycline hyclate (Dox)-loaded 40% borneol-based ISGs in N-methyl-2-
pyrrolidone (NMP) or dimethyl sulfoxide (DMSO), which were subsequently evaluated
in terms of their physicochemical properties, gel formation morphology, water
sensitivity, drug release, and antimicrobial activities. ISG density and viscosity
gradually decreased with the triacetin proportion to a viscosity of <12 cPs and
slightly influenced the surface tension (33.14-44.33 mN/m). The low expelled force
values (1.59-2.39 N) indicated the convenience of injection. All of the prepared
ISGs exhibited favorable wettability and plastic deformation. Higher gel firmness
from ISG prepared using NMP as a solvent contributed to the ability of more
efficient controlled drug release. High triacetin (25%)-loaded ISG retarded solvent
diffusion and gel formation, but diminished gel firmness and water sensitivity. ISG
containing 5% triacetin efficiently prolonged Dox release up to 10 days with
Fickian diffusion and presented effective antimicrobial activities against
periodontitis pathogens such as Porphyromonas gingivalis and Aggregatibacter
actinomycetemcomitans. Therefore, the Dox-loaded 40% borneol-based ISG with 5%
triacetin is a potential effective local ISG for periodontitis treatment.
AN - rayyan-563561127
AU - Chantadee, T.
AU - Phaechamud, T.
DO - 10.3390/gels9070557
IS - 7
J2 - Gels
LA - eng
N1 - Program of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn
University, Nakorn Pathom 73000, Thailand.; Pharmaceutical Intellectual Center
"Prachote Plengwittaya", Faculty of Pharmacy, Silpakorn University, Nakhon Pathom
Pathom 73000, Thailand.; Natural Bioactive and Material for Health Promotion and
Drug Delivery System Group (NBM), Faculty of Pharmacy, Silpakorn University, Nakhon
Pathom 73000, Thailand.; Department of Pharmaceutical Sciences, Faculty of
Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.; Natural Bioactive and
Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom
73000, Thailand.
PY - 2023
ST - Phase Inversion-Based Doxycycline Hyclate-Incorporated Borneol In Situ Gel
for Periodontitis Treatment
TI - Phase Inversion-Based Doxycycline Hyclate-Incorporated Borneol In Situ Gel
for Periodontitis Treatment
VL - 9
Y2 - 7 y3 - 7
ID - 14501
ER -
TY - JOUR
AB - BackgroundThe clinical results following regenerative endodontic procedures
(REPs) vary according to numerous parameters, including the presence of bacteria.
This limitation reduces the indications for REPs and calls for the development of
next generation antibacterial strategies (NGAS) providing alternatives to current
antibacterial strategies (CAS) such as double or triple antibiotic paste (DAP/TAP)
and (Ca(OH)2). ObjectivesThe present scoping review aims to describe the current
trends regarding the use of such strategies and highlight future perspectives.
MethodsFour databases (PUBMed, Cochrane, ClinicalTrials and Science Direct) were
searched until 1st May 2023. ResultsA total of 918 records were identified, 133
were screened and assessed for eligibility, and 87 articles were included. The
findings show that (1) clinical studies are only available for CAS, (2) although
next generation strategies are the most studied approach since 2017, they are all
at the pre-clinical stage, (3) most of the next generation strategies use galenic
forms which offer cell support and colonization and which simultaneously contain
antibacterial molecules as alternatives to CAS and to antibiotics in general, (4)
standardization is required for future research, specifically regarding the
bacterial strains studied, the use of biofilm studies and the cellular behaviour
assessments. ConclusionAlthough NGAS are promising strategies to improve REPs in
the context of infection, the current evidence is mostly limited to pre-clinical
studies. Further methodological improvement is required to allow relevant
comparisons between studies and to reduce the time from bench to bedside.
AN - rayyan-563562462
AU - Leveque, M.
AU - Guittat, M.
AU - Thivichon-Prince, B.
AU - Reuzeau, A.
AU - Eveillard, M.
AU - Faure, M.
AU - Farges, J. C.
AU - Richert, R.
AU - Bekhouche, M.
AU - Ducret, M.
DO - 10.1111/iej.13958
PY - 2023
SN - ["0143-2885", "1365-2591"]
ST - Next generation antibacterial strategies for regenerative endodontic
procedures: A scoping review
TI - Next generation antibacterial strategies for regenerative endodontic
procedures: A scoping review
Y2 - 7 y3 - 31
ID - 15836
ER -
TY - JOUR
AB - Background: A pilot randomized controlled clinical trial was performed to
evaluate the efficacy of a post-foaming dental gel containing cetylpridinium
chloride (CPC), hydrogen peroxide (H2O2), sodium bicarbonate, and antioxidants on
periodontal/oral health. Methods: Individuals with gingivitis or mild-moderate
periodontitis (n=36) were included and randomly assigned to Group 1 and 2 with
foaming gel loaded on a mouthpiece with a light source and controlled warming heat
built-in unit or on a toothbrush, respectively, in addition to regular twice-daily
brushing. Group 3 served as control with twice daily brushing and further assigned
split-mouth to Group 3a-un-flossed and Group 3b-flossed. Gingival index (GI) and
bleeding on probing (BOP) were evaluated in addition to plaque index (PI), pocket
depth, and clinical attachment level at days 14, 28, 42 (treatment), and 60
(maintenance). Subgingival plaque microbial profiles and gingival crevicular fluid
(GCF) cytokine levels were determined by DNA-DNA hybridization and multiplexing
assays, respectively. Exploratory analyses included esthetic outcomes: changes in
tooth color and levels of volatile sulfur compounds in breath. Statistical analyses
were conducted using ANOVA with a post hoc analysis of Fisher's LSD. Results: Use
of post-foaming gel in both test groups resulted in significant changes in GI and
BOP at Day 42 compared to control and un-flossed control (P<0.05). Device-enhanced
foaming gel significantly reduced the PI in Group 1 at Day 42 compared to control
and un-flossed control (P=0.02; P=0.007, respectively). GCF IL-6 and TNF-α levels
were significantly reduced in Group 2 compared to control (PIL-6=0.01, PTNF-
α=0.02). Post-foaming gel resulted in greater reductions in periodontopathogens,
whereas health-associated species remained stable. Despite cessation of adjunct
treatments, Group 1 and 2 continued having reduced levels of GI, BOP, and PI at Day
60 (P<0.05). Conclusions: The novel post-foaming dental gel improves oral health by
reducing gingival inflammation at the local site in addition to better esthetic
outcomes.
AN - rayyan-563560067
AU - Levine, J. B.
AU - Goncalves, J.
AU - Nguyen, D.
AU - Nguyen, O.
AU - Hasturk, H.
DO - 10.1002/JPER.19-0594
IS - 12
KW - NCT03196618
toothbrush
cetylpridinium chloride
cytokine
foaming agent
hydrogen peroxide
interleukin 10
interleukin 1beta
interleukin 6
interleukin 8
pyridinium derivative
unclassified drug
xylitol
adult
article
bacterial load
chewing gum
clinical article
controlled study
disease severity
drug efficacy
female
foaming
gingiva bleeding
gingival index
gingivitis
human
limit of detection
male
mouth hygiene
periodontitis
plaque index
quality of life
questionnaire
sandwich ELISA
tooth brushing
LA - English
PY - 2020
SN - 0022-3492
SP - 1569-1583
ST - Efficacy of a novel post-foaming dental gel on gingival inflammation: A
TI - Efficacy of a novel post-foaming dental gel on gingival inflammation: A
VL - 91
ID - 13441
ER -
TY - JOUR
AB - Background/Objective: Periodontitis is a widely spread oral infection and
various antibiotics are utilized for its treatment, but high oral doses and
development of antibiotic resistance limit their use. This study was aimed at
development of natural polymer-based mucoadhesive bilayer films loaded with
moxifloxacin hydrochloride (Mox) and clove essential oil (CEO) to potentially
combat bacterial infection associated with periodontitis. Methods: Films were
synthesized by double solvent casting technique having an antibiotic in the gellan
gum-based primary layer with clove oil in a hydroxyethyl cellulose-based secondary
layer. Results: Prepared films were transparent, flexible, and showed high
antibacterial response against both gram-positive and gram-negative bacteria. The
films showed excellent pharmaceutical attributes in terms of drug content, folding
endurance, swelling index, and mucoadhesive strength. Solid state characterization
of formulation showed successful incorporation of drug and oil in separate layers
of hydrogel structure. An in-vitro release study showed an initial burst release of
drug followed by sustained release for up to 48 hours. Conclusion: The prepared
mucoadhesive bilayer buccal films could be used as a potential therapeutic option
for the management of periodontitis.
AN - rayyan-563562441
AU - Li, A. Q.
AU - Khan, I. N.
AU - Khan, I. U.
AU - Yousaf, A. M.
AU - Shahzad, Y.
DO - 10.2147/DDDT.S328722
PY - 2021
SN - 1177-8881
SP - 3937-3952
ST - Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin
Hydrochloride and Clove Oil for Possible Treatment of Periodontitis
T2 - DRUG DESIGN DEVELOPMENT AND THERAPY
TI - Gellan Gum-Based Bilayer Mucoadhesive Films Loaded with Moxifloxacin
Hydrochloride and Clove Oil for Possible Treatment of Periodontitis
VL - 15
ID - 15815
ER -
TY - JOUR
AB - Background/Objective: Periodontitis is a widely spread oral infection and
various antibiotics are utilized for its treatment, but high oral doses and
development of antibiotic resistance limit their use. This study was aimed at
development of natural polymer-based mucoadhesive bilayer films loaded with
moxifloxacin hydrochloride (Mox) and clove essential oil (CEO) to potentially
combat bacterial infection associated with periodontitis. Methods: Films were
synthesized by double solvent casting technique having an antibiotic in the gellan
gum-based primary layer with clove oil in a hydroxyethyl cellulose-based secondary
layer. Results: Prepared films were transparent, flexible, and showed high
antibacterial response against both gram-positive and gram-negative bacteria. The
films showed excellent pharmaceutical attributes in terms of drug content, folding
endurance, swelling index, and mucoadhesive strength. Solid state characterization
of formulation showed successful incorporation of drug and oil in separate layers
of hydrogel structure. An in-vitro release study showed an initial burst release of
drug followed by sustained release for up to 48 hours. Conclusion: The prepared
mucoadhesive bilayer buccal films could be used as a potential therapeutic option
for the management of periodontitis.
AN - rayyan-563560047
AU - Li, A.
AU - Khan, I. N.
AU - Khan, I. U.
AU - Yousaf, A. M.
AU - Shahzad, Y.
DO - 10.2147/DDDT.S328722
KW - film
mucoadhesive film
clove oil
gellan
hydrogel
moxifloxacin
article
bacterial strain
controlled study
drug penetration
Escherichia coli
in vitro study
periodontitis
synthesis
thickness
weight
LA - English
PY - 2021
SN - 1177-8881
SP - 3937-3952
ST - Gellan gum-based bilayer mucoadhesive films loaded with moxifloxacin
hydrochloride and clove oil for possible treatment of periodontitis
T2 - Drug Des. Dev. Ther.
TI - Gellan gum-based bilayer mucoadhesive films loaded with moxifloxacin
hydrochloride and clove oil for possible treatment of periodontitis
VL - 15
ID - 13421
ER -
TY - JOUR
AB - Implant-associated infection is becoming more and more challenging to the
healthcare industry worldwide due to increasing antibiotic resistance, transmission
of antibiotic resistant bacteria between animals and humans, and the high cost of
treating infections. In this study, we disclose a new strategy that may be
effective in preventing implant-associated infection based on the potential
antimicrobial properties of platelet-rich plasma (PRP). Due to its well-studied
properties for promoting healing, PRP (a biological product) has been increasingly
used for clinical applications including orthopaedic surgeries, periodontal and
oral surgeries, maxillofacial surgeries, plastic surgeries, sports medicine, etc.
PRP could be an advanced alternative to conventional antibiotic treatments in
preventing implant-associated infections. The use of PRP may be advantageous
compared to conventional antibiotic treatments since PRP is less likely to induce
antibiotic resistance and PRP's antimicrobial and healing-promoting properties may
have a synergistic effect on infection prevention. It is well known that pathogens
and human cells are racing for implant surfaces, and PRP's properties of promoting
healing could improve human cell attachment thereby reducing the odds for
infection. In addition, PRP is inherently biocompatible, and safe and free from the
risk of transmissible diseases. For our study, we have selected several clinical
bacterial strains that are commonly found in orthopaedic infections and examined
whether PRP has in vitro antimicrobial properties against these bacteria. We have
prepared PRP using a twice centrifugation approach which allows the same platelet
concentration to be obtained for all samples. We have achieved consistent
antimicrobial findings and found that PRP has strong in vitro antimicrobial
properties against bacteria like methicillin-sensitive and methicillin-resistant
Staphylococcus aureus, Group A Streptococcus, and Neisseria gonorrhoeae. Therefore,
the use of PRP may have the potential to prevent infection and to reduce the need
for costly post-operative treatment of implant-associated infections.
AN - rayyan-563562502
AU - Li, H. S.
AU - Li, B. Y.
DO - 10.3791/50351
IS - 74
PY - 2013
SN - 1940-087X
ST - PRP as a New Approach to Prevent Infection: Preparation and In vitro
Antimicrobial Properties of PRP
T2 - JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
TI - PRP as a New Approach to Prevent Infection: Preparation and In vitro
Antimicrobial Properties of PRP
Y2 - 4
ID - 15876
ER -
TY - JOUR
AB - Aim: To investigate whether periodontitis impacts bone homeostasis via gut
microbiota regulation. Materials and Methods: Experimental periodontitis was
induced by ligatures (LIG group). ApoE−/− mice were employed as a model with
weakened bone homeostasis. Bone turnover was evaluated through micro-computerized
tomography, haematoxylin and eosin-stained sections, osteoblast and osteoclast
biomarkers in the bone and serum. Gut microbiota was analysed through 16S ribosomal
RNA gene sequencing. Serum concentrations of cytokines were detected by enzyme-
linked immunosorbent assay. The role of gut microbiota was evaluated through their
transplantation into antibiotic-treated mice. Results: Periodontitis significantly
increased the number of osteoclasts and the expression of the osteoclast biomarkers
in the proximal tibia of ApoE−/− mice, with the RANKL/OPG (receptor activator of
nuclear factor-κB ligand/osteoprotegerin) ratio significantly increased, which
indicated the osteoclastic activity overwhelmed osteogenesis. Meanwhile,
periodontitis altered the composition of gut microbiota and induced low-grade
inflammation in the colon and blood circulation. Interestingly, the concentration
of circulating tumour necrosis factor-α, interleukin (IL)-6, IL-1β, IL-17A, and
monocyte chemotactic factor-1 were positively correlated with faecal α1-antitrypsin
and calprotectin, as well as serum OPG and RANKL. Furthermore, transplantation of
gut microbiota from mice with periodontitis to antibiotic-treated mice could
partially re-capitulate the phenotypes in the bone and colon. Conclusion:
Periodontitis may impair systemic bone homeostasis through gut microbiota.
AN - rayyan-563559785
AU - Li, L.
AU - Wang, M.
AU - Bao, J.
AU - Wang, N.
AU - Huang, Y.
AU - He, S.
AU - Chen, B.
AU - Yan, F.
DO - 10.1111/jcpe.13708
IS - 12
KW - Amplification Kit
AxyPrep
Bruker Skyscan 1172
CTvox software
diagnostic kit
digital slide scanner
DNA Gel Extraction Kit
ELISA kit
fluorometer
high throughput sequencer
HiSeq PE250
PANNORAMIC MID
prism
Qubit 2.0
Rayto RT-6100
spectrophotometer
SYBR
alpha 1 antitrypsin
ampicillin
calgranulin
cross linked C telopeptide of type I collagen
eosin
hematoxylin
interleukin 17 antibody
interleukin 1beta
interleukin 6
interleukin 8
metronidazole
neomycin
occludin
osteoprotegerin
RNA 16S
unclassified drug
vancomycin
alveolar bone loss
animal experiment
animal model
animal tissue
antibiotic therapy
article
bone development
bone homeostasis
bone turnover
circulation
co housing experiment
colitis
controlled study
DNA extraction
gene amplification
high throughput sequencing
homeostasis
intestine flora
Kruskal Wallis test
ligation
male
mouse
nonhuman
osteoblast
osteoclast
osteoporosis
phenotype
procedures
proximal tibia
rank sum test
RNA sequencing
spectrophotometry
staining
transplantation
Nanodrop 2000
PrimeScript
QIAamp
LA - English
PY - 2022
SN - ["1600-051X", "0303-6979"]
SP - 1304-1319
ST - Periodontitis may impair the homeostasis of systemic bone through regulation
of gut microbiota in ApoE−/− mice
TI - Periodontitis may impair the homeostasis of systemic bone through regulation
of gut microbiota in ApoE−/− mice
VL - 49
ID - 13159
ER -
TY - JOUR
AB - Objectives: To search for a substance in lotus leaf that could efficiently be
used in toothpaste for preventing periodontal disease. Methods: Dried lotus leaves
were hydrated and fractionated using 40% butanol and 40% ethanol extraction. The
extracts and the residue were evaluated by antimicrobial sensitivity tests of broth
micro-dilution methods on 96-microwell plates for inhibition of five species of
oral bacteria: Actinobacillus actinomycetemcomitans Y4, Actinomyces viscosus 19246,
Porphyromonas gingivalis 33277, Fusobacterium nucleatum 25586, and Actinomyces
naeslundii wvl 45. The most active antimicrobial extract was then ready to use in
toothpaste. A water extract of the toothpaste was prepared and its inhibitory
activity tested. The potency of the lotus leaf extracts was compared to inhibition
observed by three commercially available toothpastes. Results: The butanol-
extracted material was separated into four fractions on silica gel. Fraction #3,
the fraction containing the most potent inhibitor, was formulated into toothpaste.
The toothpaste containing the extract showed an inhibition effect on suspicious
peridontitis-causing bacteria. Conclusion: An extract from the lotus leaf is
effective in inhibiting peridontitis-causing bacteria. The toothpaste containing
the lotus leaf-derived inhibitor could be useful in preventing periodontal disease.
© 2007 FDI/World Dental Press.
AN - rayyan-563560735
AU - Li, M. Y.
AU - Xu, Z. T.
DO - 10.1111/j.1875-595X.2007.tb00137.x
IS - 5
toothpaste
article
chemistry
evaluation study
Lotus (genus)
methodology
microbiology
periodontitis
phytotherapy
plant leaf
LA - English
PY - 2007
SN - 0020-6539
SP - 303-306
ST - The inhibition of dentifrice containing the lotus leaf-derived inhibitor on
periodontitis-related bacteria in vitro
T2 - Int. Dent. J.
TI - The inhibition of dentifrice containing the lotus leaf-derived inhibitor on
periodontitis-related bacteria in vitro
VL - 57
ID - 14109
ER -
TY - JOUR
AB - The objective of this study is to isolate and identify antibacterial
compounds from Lithospermum erythrorhizon (L. erythrorhizon). Initially, the
extracts of 44 different Traditional Chinese Medicines (TCM) were screened for
their antimicrobial sensitivity by using broth micro-dilution methods on 96-
microwell plate towards four different species of oral bacteria, which includes
Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus mutans and
Lactobacillus acidophilus. Among the 44 TCMs, the extracts from L. erythrorhizon
have proved to be most effective against these bacteria and were taken up for
further study. Further, the purification of compounds from the selected L.
erythrorhizon was performed by silica gel column chromatography. The compounds of
L. erythrorhizon were evaluated for their efficacy by using antimicrobial
sensitivity tests. Of all the extracts of L. erythrorhizon, 80% ethanol extract of
it, has shown the best antibacterial effects. The elucidation of the structure of
the isolated compounds was performed by NMR spectroscopy. Antibacterial effects of
the compounds (Acetylshikonin, shikonin, deoxyshikonin, β-sitosterol, and β, β-
dimethylacrylshikonin) obtained from the extract, showed that acetylshikonin has
the best antibacterial effects. Our study concludes that acetylshikonin of L.
erythrorhizon could be a potential antimicrobial agent for the treatment of oral
diseases. © 2012 Bentham Science Publishers.
AN - rayyan-563560537
AU - Li, M. y
AU - Xu, Z. t
AU - Zhu, C. l
AU - Wang, J.
DO - 10.2174/157341212801619324
IS - 3
KW - acetylshikonin
antiinfective agent
beta,beta dimethylacrylshikonin
deoxyshikonin
Lithospermum erythrorhizon extract
Lithospermum extract
shikonin
shikonin derivative
sitosterol
unclassified drug
article
Chinese medicine
drug efficacy
drug purification
drug screening
Lithospermum
lithospermum erythrorhizon
nonhuman
priority journal
LA - English
PY - 2012
SN - ["1573-4129", "1875-676X"]
SP - 255-260
ST - Effect of different derivatives of shikonin from lithospermum erythrorhizon
against the pathogenic dental bacteria
T2 - Curr. Pharm. Anal.
TI - Effect of different derivatives of shikonin from lithospermum erythrorhizon
against the pathogenic dental bacteria
VL - 8
ID - 13911
ER -
TY - JOUR
AB - Periodontitis is a bacterial-induced, chronic inflammatory disease
characterized by progressive destruction of tooth-supporting structures. Pathogenic
bacteria residing in deep periodontal pockets after traditional manual debridement
can still lead to local inflammatory microenvironment, which remains a challenging
problem and an urgent need for better therapeutic strategies. Here, we integrated
the advantages of metal-organic frameworks (MOFs) and hydrogels to prepare an
injectable nanocomposite hydrogel by incorporating dexamethasone-loaded zeolitic
imidazolate frameworks-8 (DZIF) nanoparticles into the photocrosslinking matrix of
methacrylic poly-phosphoester (PPEMA) and methacrylic gelatin (GelMA). The
injectable hydrogel could be easily injected into deep periodontal pockets,
achieving high local concentrations without leading to antibiotic resistance. The
nanocomposite hydrogel had high antibacterial activity and constructs with stable
microenvironments maintain cell viability, proliferation, spreading, as well as
osteogenesis, and down-regulated inflammatory genes expression in vitro. When
evaluated on an experimental periodontitis rat model, micro-computed tomography and
histo-logical analyses showed that the nanocomposite hydrogel effectively reduced
periodontal inflammation and attenuated inflammation-induced bone loss in a rat
model of periodontitis. These findings suggest that the nanocomposite hydrogel
might be a promising therapeutic candidate for treating periodontal disease.
AN - rayyan-563562012
AU - Li, N.
AU - Xie, L. Y.
AU - Wu, Y. C.
AU - Wu, Y.
AU - Liu, Y. J.
AU - Gao, Y. M.
AU - Yang, J.
AU - Zhang, X. Y.
AU - Jiang, L. T.
DO - 10.1016/j.mtbio.2022.100360
PY - 2022
SN - 2590-0064
ST - Dexamethasone-loaded zeolitic imidazolate frameworks nanocomposite hydrogel
with antibacterial and anti-inflammatory effects for periodontitis treatment
TI - Dexamethasone-loaded zeolitic imidazolate frameworks nanocomposite hydrogel
VL - 16
Y2 - 12
ID - 15386
ER -
TY - JOUR
AB - Periodontitis is a bacterial-induced, chronic inflammatory disease
characterized by progressive destruction of tooth-supporting structures. Pathogenic
bacteria residing in deep periodontal pockets after traditional manual debridement
can still lead to local inflammatory microenvironment, which remains a challenging
problem and an urgent need for better therapeutic strategies. Here, we integrated
the advantages of metal-organic frameworks (MOFs) and hydrogels to prepare an
injectable nanocomposite hydrogel by incorporating dexamethasone-loaded zeolitic
imidazolate frameworks-8 (DZIF) nanoparticles into the photocrosslinking matrix of
methacrylic polyphosphoester (PPEMA) and methacrylic gelatin (GelMA). The
injectable hydrogel could be easily injected into deep periodontal pockets,
achieving high local concentrations without leading to antibiotic resistance. The
nanocomposite hydrogel had high antibacterial activity and constructs with stable
microenvironments maintain cell viability, proliferation, spreading, as well as
osteogenesis, and down-regulated inflammatory genes expression in vitro. When
evaluated on an experimental periodontitis rat model, micro-computed tomography and
histological analyses showed that the nanocomposite hydrogel effectively reduced
periodontal inflammation and attenuated inflammation-induced bone loss in a rat
model of periodontitis. These findings suggest that the nanocomposite hydrogel
might be a promising therapeutic candidate for treating periodontal disease.
AN - rayyan-563560799
AU - Li, N.
AU - Xie, L.
AU - Wu, Y.
AU - Liu, Y.
AU - Gao, Y.
AU - Yang, J.
AU - Zhang, X.
AU - Jiang, L.
DO - 10.1016/j.mtbio.2022.100360
LA - eng
N1 - Department of Stomatology, Ruijin Hospital, Shanghai Jiao Tong University
School of Medicine; College of Stomatology, Shanghai Jiao Tong University, 200025,
Shanghai, China.; Department of Laboratory Medicine, Ruijin Hospital Affiliated to
Shanghai Jiao Tong University, School of Medicine, 200025, Shanghai, China.; Core
Facility of Basic Medical Sciences, Shanghai Jiao Tong University School of
Medicine, Shanghai, 200025, China.; Instrumental Analysis Center, School of
Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix
Composites, Shanghai Jiao Tong University, Shanghai, 200240, China.; Instrumental
Analysis Center, School of Chemistry and Chemical Engineering, State Key Laboratory
of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai, 200240,
China.; Department of Stomatology, Ruijin Hospital, Shanghai Jiao Tong University
School of Medicine; College of Stomatology, Shanghai Jiao Tong University, 200025,
Shanghai, China.; Core Facility of Basic Medical Sciences, Shanghai Jiao Tong
University School of Medicine, Shanghai, 200025, China.; Department of
Prosthodontics, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong
University School of Medicine; National Clinical Research Center for Oral Diseased;
Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of
Stomatology, 200011, Shanghai, China.; Department of Stomatology, Ruijin Hospital,
Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai
Jiao Tong University, 200025, Shanghai, China.
PY - 2022
SP - 100360
ST - Dexamethasone-loaded zeolitic imidazolate frameworks nanocomposite hydrogel
TI - Dexamethasone-loaded zeolitic imidazolate frameworks nanocomposite hydrogel
VL - 16
Y2 - 12
ID - 14173
ER -
TY - JOUR
AB - Curcumin is the main active ingredient of turmeric, which has a wide range of
pharmacological effects, including antitumor, antibacterial, anti-inflammatory,
anti-oxidation, immune regulation, and so on. Periodontitis is a prevalent oral
inflammatory disease caused by a variety of factors. In recent years, many studies
have shown that curcumin has a potential role on the treatment of periodontitis.
Curcumin has been used in research related to the treatment of periodontitis in the
form of solution, chip, gel, and capsule. Combined with other periodontitis
treatment methods, such as scaling and root planing (SRP) and photodynamic therapy
(PDT), can enhance curcumin's efficacy in treating periodontitis. In addition to
natural curcumin, chemically modified curcumin, such as 4-phenylaminocarbonyl bis-
demethoxy curcumin (CMC 2.24) and 4-methoxycarbonyl curcumin (CMC 2.5), have also
been used in animal models of periodontitis. Here, this paper reviews the research
progress of curcumin on the treatment of periodontitis and its related mechanisms.
AN - rayyan-563562216
AU - Li, Y. L.
AU - Jiao, J. J.
AU - Qi, Y. Z.
AU - Yu, W. Q.
AU - Yang, S. H.
AU - Zhang, J. J.
AU - Zhao, J. H.
DO - 10.1111/jre.12914
IS - 5
PY - 2021
SN - ["0022-3484", "1600-0765"]
SP - 837-847
ST - Curcumin: A review of experimental studies and mechanisms related to
TI - Curcumin: A review of experimental studies and mechanisms related to
VL - 56
Y2 - 10
ID - 15590
ER -
TY - JOUR
AB - Introduction: Although endodontic infection is caused by multi-bacteria
species, Enterococcus faecalis is usually isolated in chronic apical periodontitis.
The aim of this study was to evaluate the effectiveness and mechanical safety of
cold plasma therapy in disinfecting 3-week E. faecalis biofilms. Methods: Teeth
with 3-week E. faecalis biofilm were treated with AC argon/oxygen (Ar/O-2) cold
plasma for various treatment times and compared with those treated with Ca(OH)(2),
2% chlorhexidine gel, and Ca(OH)(2)/chlorhexidine for a week. Antimicrobial
efficacy was assessed by colony-forming unit method. Scanning electron microscopy
was used to assess the morphologic changes of E. faecalis biofilm by plasma.
Confocal laser scanning microscopy was used to confirm the viability of the biofilm
after the plasma treatment. Microhardness and roughness changes of root canal
dentin caused by plasma were verified with Vickers Hardness Tester and 3D Profile
Measurement Laser Microscope, respectively. Results: There were no detectable live
bacteria after 12 minutes of cold plasma treatment. This was further confirmed by
scanning electron microscopy and confocal laser scanning microscopy results.
Microhardness and roughness of root canal dentin showed no significant difference
after plasma treatment. Conclusions: Atmospheric pressure cold plasma is an
effective therapy in endodontics for its strong sterilization effect on fully
matured biofilm within a few minutes. Meanwhile, it has art accepted mechanical
safety for its low temperature and not affecting the microhardness and roughness of
root canal dentin significantly.
AN - rayyan-563562577
AU - Li, Y. L.
AU - Sun, K.
AU - Ye, G. P.
AU - Liang, Y. D.
AU - Pan, H.
AU - Wang, G. M.
AU - Zhao, Y. J.
AU - Pan, J.
AU - Zhang, J.
AU - Fang, J.
DO - 10.1016/j.joen.2014.10.020
IS - 8
PY - 2015
SN - ["0099-2399", "1878-3554"]
SP - 1325-1330
ST - Evaluation of Cold Plasma Treatment and Safety in Disinfecting 3-week Root
Canal Enterococcus faecalis Biofilm In Vitro
TI - Evaluation of Cold Plasma Treatment and Safety in Disinfecting 3-week Root
VL - 41
Y2 - 8
ID - 15951
ER -
TY - JOUR
AB - Curcumin is the main active ingredient of turmeric, which has a wide range of
pharmacological effects, including antitumor, antibacterial, anti-inflammatory,
anti-oxidation, immune regulation, and so on. Periodontitis is a prevalent oral
inflammatory disease caused by a variety of factors. In recent years, many studies
have shown that curcumin has a potential role on the treatment of periodontitis.
Curcumin has been used in research related to the treatment of periodontitis in the
form of solution, chip, gel, and capsule. Combined with other periodontitis
treatment methods, such as scaling and root planing (SRP) and photodynamic therapy
(PDT), can enhance curcumin's efficacy in treating periodontitis. In addition to
natural curcumin, chemically modified curcumin, such as 4-phenylaminocarbonyl bis-
demethoxy curcumin (CMC 2.24) and 4-methoxycarbonyl curcumin (CMC 2.5), have also
been used in animal models of periodontitis. Here, this paper reviews the research
progress of curcumin on the treatment of periodontitis and its related mechanisms.
AN - rayyan-563559957
AU - Li, Y.
AU - Jiao, J.
AU - Qi, Y.
AU - Yu, W.
AU - Yang, S.
AU - Zhang, J.
AU - Zhao, J.
DO - 10.1111/jre.12914
IS - 5
curcumin
animal
dental scaling
periodontitis
root planing
LA - English
PY - 2021
SN - 1600-0765
SP - 837-847
ST - Curcumin: A review of experimental studies and mechanisms related to
T2 - J Periodontal Res
TI - Curcumin: A review of experimental studies and mechanisms related to
VL - 56
ID - 13331
ER -
TY - JOUR
AB - The pathophysiology of periodontal disease involves a perturbed immune system
to a dysbiotic microflora leading to unrestrained inflammation, collateral tissue
damage, and various systemic complications. Gingival epithelial cells function as
an important part of immunity to restrict microbial invasion and orchestrate the
subsequent innate responses. A20 (TNFAIP3), an ubiquitin-editing enzyme, is one of
the key regulators of inflammation and cell death in numerous tissues including
gastrointestinal tract, skin, and lungs. Emerging evidence indicates A20 as an
essential molecule in the oral mucosa as well. In this study, we characterized the
role of A20 in human telomerase immortalized gingival keratinocytes (TIGKs) through
loss and gain of function assays in preclinical models of periodontitis. Depletion
of A20 through gene editing in TIGKs significantly increased IL-6 and IL-8
secretion in response to Porphyromonas gingivalis infection while A20 over-
expression dampened the cytokine production compared to A20 competent cells through
modulating NF-κB signaling pathway. In the subsequent experiments which assessed
apoptosis, A20 depleted TIGKs displayed increased levels of cleaved caspase 3 and
DNA fragmentation following P. gingivalis infection and TNF/CHX challenge compared
to A20 competent cells. Consistently, there was reduced apoptosis in the cells
overexpressing A20 compared to the control cells expressing GFP further
substantiating the role of A20 in regulating gingival epithelial cell fate in
response to exogenous insult. Collectively, our findings reveal first systematic
evidence and demonstrate that A20 acts as a regulator of inflammatory response in
gingival keratinocytes through its effect on NF-κB signaling and desensitizes cells
to bacteria and cytokine induced apoptosis in the oral mucosa. As altered A20
levels can have profound effect on different cellular responses, future studies
will determine whether A20-targeted therapies can be exploited to restrain
periodontal inflammation and maintain oral mucosa tissue homeostasis.
AN - rayyan-563560129
AU - Li, Y.
AU - Mooney, E. C.
AU - Xia, X. J.
AU - Gupta, N.
AU - Sahingur, S. E.
DO - 10.3389/fimmu.2020.00365
KW - caspase 3
interleukin 6
interleukin 8
tumor necrosis factor alpha induced protein 3
apoptosis
article
bacterial strain
bacterium culture
controlled study
cytokine production
DNA fragmentation
gene editing
gene overexpression
immunofluorescence
keratinocyte
mouth mucosa
nonhuman
periodontitis
protein depletion
protein expression
signal transduction
upregulation
LA - English
PY - 2020
SN - 1664-3224
ST - A20 Restricts Inflammatory Response and Desensitizes Gingival Keratinocytes
to Apoptosis
TI - A20 Restricts Inflammatory Response and Desensitizes Gingival Keratinocytes
to Apoptosis
VL - 11
ID - 13503
ER -
TY - JOUR
AB - INTRODUCTION: Although endodontic infection is caused by multi-bacteria
species, Enterococcus faecalis is usually isolated in chronic apical periodontitis.
The aim of this study was to evaluate the effectiveness and mechanical safety of
cold plasma therapy in disinfecting 3-week E. faecalis biofilms. METHODS: Teeth
with 3-week E. faecalis biofilm were treated with AC argon/oxygen (Ar/O2) cold
plasma for various treatment times and compared with those treated with Ca(OH)2, 2%
chlorhexidine gel, and Ca(OH)2/chlorhexidine for a week. Antimicrobial efficacy was
assessed by colony-forming unit method. Scanning electron microscopy was used to
assess the morphologic changes of E. faecalis biofilm by plasma. Confocal laser
scanning microscopy was used to confirm the viability of the biofilm after the
plasma treatment. Microhardness and roughness changes of root canal dentin caused
by plasma were verified with Vickers Hardness Tester and 3D Profile Measurement
Laser Microscope, respectively. RESULTS: There were no detectable live bacteria
after 12 minutes of cold plasma treatment. This was further confirmed by scanning
electron microscopy and confocal laser scanning microscopy results. Microhardness
and roughness of root canal dentin showed no significant difference after plasma
treatment. CONCLUSIONS: Atmospheric pressure cold plasma is an effective therapy in
endodontics for its strong sterilization effect on fully matured biofilm within a
few minutes. Meanwhile, it has an accepted mechanical safety for its low
temperature and not affecting the microhardness and roughness of root canal dentin
significantly.
AN - rayyan-563560377
AU - Li, Y.
AU - Sun, K.
AU - Ye, G.
AU - Liang, Y.
AU - Pan, H.
AU - Wang, G.
AU - Zhao, Y.
AU - Pan, J.
AU - Zhang, J.
AU - Fang, J.
DO - 10.1016/j.joen.2014.10.020
IS - 8
argon
oxygen
plasma gas
adverse event
biofilm
confocal microscopy
dental pulp cavity
dentin
drug effect
evaluation study
Gram positive infection
hardness
human
microbiology
pathology
pathophysiology
physiology
procedures
pulpitis
therapeutic use
time factor
ultrastructure
LA - English
PY - 2015
SN - 1878-3554
SP - 1325-1330
ST - Evaluation of Cold Plasma Treatment and Safety in Disinfecting 3-week Root
T2 - J Endod
TI - Evaluation of Cold Plasma Treatment and Safety in Disinfecting 3-week Root
VL - 41
ID - 13751
ER -
TY - JOUR
AB - Biofilm of oral pathogenic microorganisms induced by their multiplication and
coaggregation would lead to periodontitis. In biofilms, the extracellular polymeric
substances (EPS) as a protective shield encapsulates the individual bacteria,
protecting them against attack. To alleviate periodontal disease, disrupting the
EPS of pathogenic bacteria is crucial and challenging. Based on the sufficient
capacity of disorganizing EPS of our designed cationic dextrans, we hypothesized
that these polymers could be competent in relieving periodontitis. We validated
that cationic dextrans could induce the phase transition of EPS in biofilms,
especially the Porphyromonas gingivalis (P. gingivalis), a keystone periodontal
pathogen, thus effectively destroying biofilm in vitro. More importantly,
satisfactory in vivo treatment was achieved in a rat periodontal disease model. In
summary, the study exploited a practical and effective strategy to treat
periodontitis with cationic dextrans’ powerful biofilm-controlling potential.
Statement of significance: Periodontal disease is closely related to dental plaque
biofilms on the tooth surface. The biofilm forms gel structures and shields the
bacteria underneath, thus protecting oral pathogens from traditional anti-bacterial
reagents. Due to limited penetration into gel, the efficacy of these reagents in
biofilm elimination is restricted. Our designed cationic dextran could wipe out the
coverage of gel-like EPS to disperse encapsulated bacteria. Such superior capacity
endowed them with satisfactory effect in disrupting biofilm. Notably, in a rat
periodontitis model, cationic dextrans dramatically suppressed alveolar bone loss
and alleviated periodontal inflammation by controlling dental plaque. Given the
increasing global concerns about periodontal disease, it's worth expanding the
application of cationic dextrans both scientifically and clinically.
AN - rayyan-563559742
AU - Li, Y.
AU - Xing, Z.
AU - Wang, S.
AU - Wang, Y.
AU - Wang, Z.
AU - Dong, L.
DO - 10.1016/j.actbio.2023.01.008
KW - micro-CT scanner
skyscan1176
c dex
chlorhexidine
deta dex
dextran derivative
hydroxyapatite
pentobarbital
animal experiment
animal model
animal tissue
article
biofilm matrix
controlled study
Escherichia coli
female
in vitro study
in vivo study
inflammation
nonhuman
osteolysis
periodontitis
periodontium
phase transition
rat
tooth plaque
LA - English
PY - 2023
SN - ["1878-7568", "1742-7061"]
SP - 759-768
ST - Disruption of biofilms in periodontal disease through the induction of phase
transition by cationic dextrans
T2 - Acta Biomater.
TI - Disruption of biofilms in periodontal disease through the induction of phase
transition by cationic dextrans
VL - 158
ID - 13116
ER -
TY - JOUR
AB - The guided bone regeneration (GBR) concept has been extensively utilized to
treat maxillofacial bone defects in clinical practice. However, the repair efficacy
of currently available GBR membranes is often compromised by their limited bone
regeneration potential and deficient antibacterial activity. In this study,
inspired by the bi-layered structure design of the commonly used Bio-Gide R?
membrane, we designed and fabricated a new kind of multifunctional bi-layered "GBR
scaffold" combining solution electrospinning writing (SEW) and solution
electrospinning (SES) techniques using a single SEW printer. Copper loaded
mesoporous silica nanoparticles (Cu@MSNs) were incorporated into the poly(lactic-
co-glycolic acid)/gelatin (PLGA/Gel, denoted as PG) fiber matrix to construct a
composite PG-Cu@MSNs fibrous scaffold. The obtained GBR scaffold consisted of a
loose and porous SEW layer to support and facilitate bone ingrowth, and a dense and
compact SES layer to resist non-osteoblast interference. The resulting enhanced
mechanical properties, coordinated degradation profile, and facile preparation
procedure imparted the composite scaffold with good clinical feasibility. In vitro
biological experiments indicate that the PGCu@MSNs composite scaffold exhibited
favorable osteogenic and antibacterial properties. Furthermore, an in vivo rat
periodontal defect model further confirmed the promising bone regeneration efficacy
of the PG-Cu@MSNs scaffold. In conclusion, the developed electrowritten Cu@MSNs-
incorporated bi-layered scaffold with hierarchical architecture and concurrent
osteogenic and antibacterial functions may hold great potential for application in
GBR. (c) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
AN - rayyan-563562579
AU - Lian, M. F.
AU - Han, Y.
AU - Sun, B. B.
AU - Xu, L.
AU - Wang, X. F.
AU - Ni, B.
AU - Jiang, W. B.
AU - Qiao, Z. G.
AU - Dai, K. R.
AU - Zhang, X. Y.
DO - 10.1016/j.actbio.2020.08.017
PY - 2020
SN - ["1742-7061", "1878-7568"]
SP - 83-99
ST - A multifunctional electrowritten bi-layered scaffold for guided bone
regeneration
T2 - ACTA BIOMATERIALIA
TI - A multifunctional electrowritten bi-layered scaffold for guided bone
regeneration
VL - 118
Y2 - 12
ID - 15953
ER -
TY - JOUR
AB - The guided bone regeneration (GBR) concept has been extensively utilized to
treat maxillofacial bone defects in clinical practice. However, the repair efficacy
of currently available GBR membranes is often compromised by their limited bone
regeneration potential and deficient antibacterial activity. In this study,
inspired by the bi-layered structure design of the commonly used Bio-Gidemembrane,
we designed and fabricated a new kind of multifunctional bi-layered “GBR scaffold”
combining solution electrospinning writing (SEW) and solution electrospinning (SES)
techniques using a single SEW printer. Copper-loaded mesoporous silica
nanoparticles (Cu@MSNs) were incorporated into the poly(lactic-co-glycolic
acid)/gelatin (PLGA/Gel, denoted as PG) fiber matrix to construct a composite PG-
Cu@MSNs fibrous scaffold. The obtained GBR scaffold consisted of a loose and porous
SEW layer to support and facilitate bone ingrowth, and a dense and compact SES
layer to resist non-osteoblast interference. The resulting enhanced mechanical
properties, coordinated degradation profile, and facile preparation procedure
imparted the composite scaffold with good clinical feasibility. In vitro biological
experiments indicate that the PG-Cu@MSNs composite scaffold exhibited favorable
osteogenic and antibacterial properties. Furthermore, an in vivo rat periodontal
defect model further confirmed the promising bone regeneration efficacy of the PG-
Cu@MSNs scaffold. In conclusion, the developed electrowritten Cu@MSNs-incorporated
bi-layered scaffold with hierarchical architecture and concurrent osteogenic and
antibacterial functions may hold great potential for application in GBR.
AN - rayyan-563560072
AU - Lian, M.
AU - Han, Y.
AU - Sun, B.
AU - Xu, L.
AU - Wang, X.
AU - Ni, B.
AU - Jiang, W.
AU - Qiao, Z.
AU - Dai, K.
AU - Zhang, X.
DO - 10.1016/j.actbio.2020.08.017
KW - analyzer
centrifuge
dental burr
DP 71
microscope
spectrometer
tube
copper
gelatin
molecular scaffold
nanocomposite
polyglactin
animal cell
animal experiment
article
biocompatibility
bone regeneration
cell infiltration
controlled study
electrospinning
electrospinning writing
feasibility study
guided bone regeneration
in vitro study
in vivo study
nonhuman
osteoblast
priority journal
rat
solution electrospinning
Nicolet 6700
LA - English
PY - 2020
SN - ["1878-7568", "1742-7061"]
SP - 83-99
ST - A multifunctional electrowritten bi-layered scaffold for guided bone
regeneration
T2 - Acta Biomater.
TI - A multifunctional electrowritten bi-layered scaffold for guided bone
regeneration
VL - 118
ID - 13446
ER -
TY - JOUR
AB - Oral and dental diseases, including periodontal disease, are among the most
common conditions in the field of dentistry. The best treatment for this
complication is the use of different polymers and multi-component biological tissue
prepared through the freeze-drying technique. In this study, biocompatible and
biodegradable polymers, namely polyvinyl alcohol (PVA) and gelatin (GN), were used
for this purpose, along with Arabian gumhydroxyapatite (HA) for its antibacterial
properties. Arabian gum, with weight percentages of 0, 2, 4, and 6 wt%, was added
to the polyvinyl alcohol-gelatin composition at -55 degrees C for 28 h in the
freezer and 48 h at -45 degrees C under a pressure of 0.01 mbar. The resulting
porous biological tissue, with four different ratios, was tested for mechanical and
biological analysis in a physiological solution. Then, the samples were analyzed
using a scanning electron microscope (SEM) and X-ray diffraction (XRD) technique to
study the morphology and structure of the compounds before and after placement in
biological solutions. Additionally, a wettability and antibacterial test were
performed on the nanocomposite specimen. The SEM observations reveal that this
method can create a porous structure with a porosity of about 30-50 mu m with a
spherical and circular architecture, which was further improved by the addition of
gum, reducing the percentage of porosity and improving the tissue's tensile
strength and elastic modulus. The porosity changes showed a decrease from 72 % to
60 %, and the tensile strength increased from 53.5 kPa to 76 kPa, resulting in an
elastic modulus of 510 kPa to 800 kPa. The addition of gum also reduced the rate of
destruction of the biological tissue, making it more suitable for soft tissue
applications. The obtained results of the pH test showed that the concentration
changes were neutral. The contact angle of water droplets was measured to determine
hydrophilicity, indicating an improvement in hydrophilicity after the addition of
gum. The results showed that the use of PVA and gelatin, due to their ductility and
suitable mechanical properties, along with Arabian gum-HA, could accelerate the
healing process of dental periodontal problems.
AN - rayyan-563562592
AU - Liang, H. X.
AU - Wang, Z. M.
AU - Wu, J. S.
AU - Li, X.
AU - Semirumi, D. T.
DO - 10.1016/j.ijbiomac.2023.124544
PY - 2023
SN - ["0141-8130", "1879-0003"]
ST - Microstructural and micromechanical modeling of gum-gelatin-based soft tissue
engineering scaffolds
TI - Microstructural and micromechanical modeling of gum-gelatin-based soft tissue
engineering scaffolds
VL - 241
Y2 - 6 y3 - 30
ID - 15966
ER -
TY - JOUR
AB - Photodynamic therapy with toluidine blue O (TBO) hydrogel exhibits
antibacterial activity against Staphylococcus aureus and Escherichia coli in this
paper. The response surface methodology is employed to optimize formulations for
antibacterial activity. The optimal formulations are carbomer concentration of 3%
(w/v), TBO concentration of 0.1 mg/mL and the quality ratio of NaOH and carbomer of
0.4 (w/w). Under the optimized formulations, the log-transformed of CFU on the
Staphylococcus aureus and Escherichia colt are 0.84 and 1.26 (the log-transformed
of CFU mL(-1) of negative control groups on the Staphylococcus aureus and
Escherichia coli are 8.21 and 8.47), respectively. In comparison with photodynamic
therapy with TBO aqueous solution, the proposed formulations provide a much
stronger antibacterial activity against Staphylococcus aureus and Escherichia coll.
TBO hydrogels are stable during 6 weeks at three different temperatures (4, 25 and
40 degrees C) with respect to no change of color, transparency, pH and viscosity.
50% and 68.26% of TBO are released from carbomer hydrogel after 4 h and 24 h,
respectively. TBO hydrogel alone or light alone (630 nm) treatment is incapable of
showing antibacterial activity against Staphylococcus aureus and Escherichia coll.
Therefore, photodynamic therapy with the novel optimized TBO hydrogel formulations
is a promising treatment strategy for periodontitis.
AN - rayyan-563562189
AU - Liang, H.
AU - Xu, J. L.
AU - Liu, Y. F.
AU - Zhang, J. X.
AU - Peng, W.
AU - Yan, J. H.
AU - Li, Z. L.
AU - Li, Q. Y.
DO - 10.1016/j.jphotobiol.2017.06.019
PY - 2017
SN - 1011-1344
SP - 389-396
ST - Optimization of hydrogel containing toluidine blue O for photodynamic therapy
by response surface methodology
T2 - JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
TI - Optimization of hydrogel containing toluidine blue O for photodynamic therapy
VL - 173
Y2 - 8
ID - 15563
ER -
TY - JOUR
AB - Photodynamic therapy with toluidine blue O (TBO) hydrogel exhibits
antibacterial activity against Staphylococcus aureus and Escherichia coli in this
paper. The response surface methodology is employed to optimize formulations for
antibacterial activity. The optimal formulations are carbomer concentration of 3%
(w/v), TBO concentration of 0.1 mg/mL and the quality ratio of NaOH and carbomer of
0.4 (w/w). Under the optimized formulations, the log-transformed of CFU mL− 1 on
the Staphylococcus aureus and Escherichia coli are 0.84 and 1.26 (the log-
transformed of CFU mL− 1 of negative control groups on the Staphylococcus aureus
and Escherichia coli are 8.21 and 8.47), respectively. In comparison with
photodynamic therapy with TBO aqueous solution, the proposed formulations provide a
much stronger antibacterial activity against Staphylococcus aureus and Escherichia
coli. TBO hydrogels are stable during 6 weeks at three different temperatures (4,
25 and 40 °C) with respect to no change of color, transparency, pH and viscosity.
50% and 68.26% of TBO are released from carbomer hydrogel after 4 h and 24 h,
respectively. TBO hydrogel alone or light alone (630 nm) treatment is incapable of
showing antibacterial activity against Staphylococcus aureus and Escherichia coli.
Therefore, photodynamic therapy with the novel optimized TBO hydrogel formulations
is a promising treatment strategy for periodontitis.
AN - rayyan-563560293
AU - Liang, H.
AU - Xu, J.
AU - Liu, Y.
AU - Zhang, J.
AU - Peng, W.
AU - Yan, J.
AU - Li, Z.
AU - Li, Q.
DO - 10.1016/j.jphotobiol.2017.06.019
KW - carbomer
tolonium chloride
aqueous solution
article
controlled study
drug formulation
drug release
drug stability
Escherichia coli
hydrogel
nonhuman
periodontitis
priority journal
thermostability
LA - English
PY - 2017
SN - ["1873-2682", "1011-1344"]
SP - 389-396
ST - Optimization of hydrogel containing toluidine blue O for photodynamic therapy
T2 - J. Photochem. Photobiol. B Biol.
TI - Optimization of hydrogel containing toluidine blue O for photodynamic therapy
VL - 173
ID - 13667
ER -
TY - JOUR
AB - Previously we have demonstrated that sclerostin inhibits stress-induced
odontogenic differentiation of odontoblasts and accelerates senescence of dental
pulp cells (DPCs) Odontoblasts and DPCs are main functioning cells for inflammation
resistance and tissue regeneration in dentine-pulp complex. Sclerostin is relevant
for systemic inflammation and chronic periodontitis processes, but its effects on
dental pulp inflammation remains unclear. In this study, we found that sclerostin
expression of odontoblasts was elevated in lipopolysaccharide-induced inflammatory
environment, and exogenous sclerostin increased the production of pro-inflammatory
cytokines in inflamed odontoblasts. Furthermore, sclerostin activated the NF-κB
signaling pathway in inflamed odontoblasts and the NF-κB inhibitor reversed the
exaggerative effects of sclerostin on the pro-inflammatory cytokines production.
Additionally, sclerostin promoted adhesion and migration of inflamed DPCs, while
inhibiting odontoblastic differentiation of inflamed DPCs. Sclerostin also might
enhance pulpal angiogenesis. Taken together, it can therefore be inferred that
sclerostin is upregulated in inflamed odontoblasts under pulpal inflammatory
condition to enhance inflammatory responses in dentine-pulp complex and impair
reparative dentinogenesis. This indicates that sclerostin inhibition might be a
therapeutic target for anti-inflammation and pro-regeneration during dental pulp
inflammation.
AN - rayyan-563560168
AU - Liao, C.
AU - Wang, Y.
AU - Ou, Y.
AU - Wu, Y.
AU - Zhou, Y.
AU - Liang, S.
DO - 10.1016/j.biocel.2019.105628
bone sialoprotein
cell adhesion molecule 1
chemokine receptor CXCR4
interleukin 1beta
interleukin 6
interleukin 8
osteocalcin
osteopontin
placental growth factor
sclerostin
vasculotropin
vasculotropin receptor
adult
angiogenesis
article
binding site
cell adhesion
cell aging
cell migration
cell regeneration
controlled study
electrophoresis
human
human cell
human experiment
human tissue
normal human
odontoblast
phenotype
signal transduction
third molar
tissue regeneration
tooth pulp
Western blotting
young adult
LA - English
PY - 2019
SN - ["1878-5875", "1357-2725"]
ST - Effects of sclerostin on lipopolysaccharide-induced inflammatory phenotype in
human odontoblasts and dental pulp cells
T2 - Int. J. Biochem. Cell Biol.
TI - Effects of sclerostin on lipopolysaccharide-induced inflammatory phenotype in
human odontoblasts and dental pulp cells
VL - 117
ID - 13542
ER -
TY - JOUR
AB - THE PRESENT STUDY WAS PERFORMED to assess and compare the clinical healing
and the microbiological findings following local application of metronidazole or
tetracycline to augment subgingival scaling in previously untreated adult
periodontitis sites. Eighteen patients with moderate to severe adult periodontitis
at single-rooted teeth were selected. In each patient, 3 interproximal sites having
comparable root anatomy, probing depth ≤5 mm and bleeding on probing were randomly
assigned to 1 of 3 treatment groups: 1) two sessions of subgingival scaling and
root planing; 2) similar to 1, with each treatment supplemented with a 25%
metronidazole sustained release gel; 3) similar to 1 with each treatment
supplemented with a 3% tetracycline ointment. The treatments were performed by 1
operator and the clinical variables probing depth, attachment level, and bleeding
on probing were evaluated at baseline, 3 months and 6 months by a second blinded
examiner. The microbiological findings were evaluated using a commercial test kit.
The average probing depth reduction for the 3 groups at 6 months was 1.5 mm and the
average gain of clinical attachment was 0.8 mm. There were no significant
differences between the effects following topical application of the metronidazole
gel or the tetracycline ointment. Scaling and root planning alone appeared as
effective as the drug augmented regimens, although there was a weak but non-
significant tendency for better results in sites with the antibiotic drugs.
Actinobacillus actinomycetemcomitans was generally not detected; Prevotella
intermedia was not significantly reduced, the Porphyromonas gingivalis was
significantly reduced in all treatment groups. It was concluded that the
augmentative effect of the metronidazole gel and the tetracycline ointment was
comparable but small compared to scaling and root planning alone. The clinical
importance of such small augmentation effects should be further evaluated.
AN - rayyan-563561026
AU - Lie, T.
AU - Bruun, G.
AU - Böe, O. E.
DO - 10.1902/jop.1998.69.7.819
IS - 7
KW - metronidazole
tetracycline
adult
aged
article
clinical article
comparative study
controlled study
human
ointment
periodontitis
sustained release preparation
tooth root
LA - English
PY - 1998
SN - 0022-3492
SP - 819-827
ST - Effects of topical metronidazole and tetracycline in treatment of adult
periodontitis
TI - Effects of topical metronidazole and tetracycline in treatment of adult
periodontitis
VL - 69
ID - 14400
ER -
TY - JOUR
AB - Background: Various adjunctive to non-surgical instrumentation strategies are
proposed to improve the healing outcome. Recent clinical trials point out that
chloramine gel (Perisolv) used during subgingival instrumentation and followed by
application of cross-linked hyaluronic acid (xHyA) for sealing the residual pocket
at the SPT results in significant reduction of inflammation (BoP) and an improved
periodontal pocket depth (PPD). The case series presents preliminary results of an
ongoing clinical study in SPT patients based upon PPD and BoP change. Description
of the procedure: Patients with diagnosis of periodontitis stage 3 and 4 who
previously received non-surgical treatment and presented at SPT with persistent
residual progredient pocket depths (>5 mm with BoP +) were consecutively enrolled.
After reevaluation and reinstruction residual sites were instrumented repeatedly
using chloramine gel application before and during subgingival scaling for several
times. Local and aesthetics were used according to patient's request. After
instrumentation completed, xHyA gel was applied subgingivally and patients were
instructed to abstain from irrigating, drinking and chewing for some hours. Within
the first week after instrumentation the xHyA gel application was repeated.
Outcomes: Currently 20 patients with a total of 59 are followed-up for at least 2
subsequently scheduled SPT visit resulting in 6 months post-op period. Mean age was
54.4 ± 12.3 years. The initial mean PPD at treatment visit was 7.3 ± 1.8 mm
calculated for 59 sites. At 3 months evaluation the mean PPD was calculated with
5.4 ± 1.7 mm. The PPD reduction was statistically significant (p = 0.000) at the
first reevaluation 3 months post-op while thereafter it remained unchanged at 6
months evaluation. BoP was reduced by 50%. Conclusions: From these preliminary
clinical data we conclude that the adjunctive use of chloramine gel together with
xHyA application appears to sufficiently support the outcome of subgingival
instrumentation in persisting sites by effectively reducing inflammatory response
and significantly reduced PPD.
AN - rayyan-563559839
AU - Liedloff, P.
AU - Bilhan, H.
AU - Friedmann, A.
DO - 10.1111/jcpe.13637
monochloramine
adult
bleeding on probing
case report
case study
clinical article
clinical trial
conference abstract
drinking
drug therapy
esthetics
female
human
inflammation
male
mastication
middle aged
outcome assessment
periodontitis
LA - English
PY - 2022
SN - 1600-051X
SP - 296-297
ST - Chloramine gel and hyaluronic acid gel enhance effect of non-surgical
instrumentation in persistent residual periodontal pockets - Preliminary report
from a clinical case series
TI - Chloramine gel and hyaluronic acid gel enhance effect of non-surgical
instrumentation in persistent residual periodontal pockets - Preliminary report
from a clinical case series
VL - 49
ID - 13213
ER -
TY - JOUR
AB - To compare via a split-mouth randomized clinical trial the efficacy of 1%
chlorhexidine gel, calcium hydroxide/camphorated paramonochlorophenol (Callen
PMCC), and a one-visit endodontic treatment against mutans streptococci and
anaerobic bacteria found in primary molars with necrotic pulps and to assess
clinical success rates after 12 months. Pre- and posttreatment intracanal samples
were collected from 37 teeth (from 21 children) for analysis of the number of
mutans streptococci and anaerobic bacteria. Clinical and radiographic criteria were
analyzed to determine treatment outcome. Chlorhexidine gel significantly reduced
mutans streptococci levels (P = .010), whereas Callen PMCC significantly reduced
the levels of anaerobic bacteria (P = .002). No differences in the reduction of
mutans streptococci (P = .187) and anaerobes (P = .564) were observed between
groups. The clinical success rates were 85.71% (Callen PMCC), 78.57% (chlorexidine
gel), and 77.77% (one-visit treatment). Teeth treated with Callen PMCC presented
the highest clinical success rate. The 1% chlorhexidine gel, as well as calcium
hydroxide/camphorated paramonochlorophenol, presented limited efficacy in reducing
bacteria from necrotic primary root canals.
AN - rayyan-563560500
AU - Lima, R. A.
AU - Ribeiro, T. R.
AU - Fonteles, C. S.
IS - 2
calcium hydroxide
camphor
camphorated parachlorophenol
chlorhexidine
chlorophenol
anaerobic bacterium
article
bacterial load
child
comparative study
controlled study
deciduous tooth
drug combination
drug effect
endodontics
follow up
human
methodology
microbiology
molar tooth
oroantral fistula
periodontal abscess
preschool child
tooth crown
tooth pulp
tooth pulp disease
treatment outcome
LA - English
PY - 2013
SN - 1936-7163
SP - 113-122
ST - Antimicrobial efficacy of chlorhexidine and calcium hydroxide/camphorated
paramonochlorophenol on infected primary molars: a split-mouth randomized clinical
trial
TI - Antimicrobial efficacy of chlorhexidine and calcium hydroxide/camphorated
trial
VL - 44
ID - 13874
ER -
TY - COMP
AB - OBJECTIVE: To compare via a split-mouth randomized clinical trial the
efficacy of 1% chlorhexidine gel, calcium hydroxide/camphorated
paramonochlorophenol (Callen PMCC), and a one-visit endodontic treatment against
mutans streptococci and anaerobic bacteria found in primary molars with necrotic
pulps and to assess clinical success rates after 12 months. METHOD AND MATERIALS:
Pre- and posttreatment intracanal samples were collected from 37 teeth (from 21
children) for analysis of the number of mutans streptococci and anaerobic bacteria.
Clinical and radiographic criteria were analyzed to determine treatment outcome.
RESULTS: Chlorhexidine gel significantly reduced mutans streptococci levels (P
= .010), whereas Callen PMCC significantly reduced the levels of anaerobic bacteria
(P = .002). No differences in the reduction of mutans streptococci (P = .187) and
anaerobes (P = .564) were observed between groups. The clinical success rates were
85.71% (Callen PMCC), 78.57% (chlorexidine gel), and 77.77% (one-visit treatment).
CONCLUSION: Teeth treated with Callen PMCC presented the highest clinical success
rate. The 1% chlorhexidine gel, as well as calcium hydroxide/camphorated
paramonochlorophenol, presented limited efficacy in reducing bacteria from necrotic
primary root canals.
AN - rayyan-563561330
AU - Lima, R. A.
AU - Ribeiro, T. R.
AU - Fonteles, C. S.
CY - Germany
DO - 10.3290/j.qi.a28932
ET - 2
J2 - Quintessence Int
KW - Anti-Infective Agents, Local/*therapeutic use
Bacteria, Anaerobic/drug effects
Calcium Hydroxide/*therapeutic use
Camphor/*therapeutic use
Child
Child, Preschool
Chlorophenols/*therapeutic use
Crowns
Dental Fistula/therapy
Dental Pulp Cavity/microbiology
Dental Pulp Necrosis/microbiology/*therapy
Drug Combinations
Follow-Up Studies
Gram-Negative Bacteria/drug effects
Gram-Positive Bacteria/drug effects
Humans
Molar/*microbiology
Periodontal Abscess/therapy
Root Canal Filling Materials/therapeutic use
Root Canal Preparation/methods
Root Canal Therapy/methods
Tooth, Deciduous/*microbiology
Treatment Outcome
LA - eng
N1 - Postgraduate Program in Dentistry, Federal Imoversotu pf Ceará, Fortaleza,
Brazil.
PY - 2013
SP - 113-22
trial
T2 - Quintessence international (Berlin, Germany : 1985)
trial
VL - 44
Y2 - 2
ID - 14704
ER -
TY - JOUR
AB - OBJECTIVE: To compare via a split-mouth randomized clinical trial the
efficacy of 1% chlorhexidine gel, calcium hydroxide/camphorated
paramonochlorophenol (Callen PMCC), and a one-visit endodontic treatment against
mutans streptococci and anaerobic bacteria found in primary molars with necrotic
pulps and to assess clinical success rates after 12 months. METHOD AND MATERIALS:
Pre- and posttreatment intracanal samples were collected from 37 teeth (from 21
children) for analysis of the number of mutans streptococci and anaerobic bacteria.
Clinical and radiographic criteria were analyzed to determine treatment outcome.
RESULTS: Chlorhexidine gel significantly reduced mutans streptococci levels (P
= .010), whereas Callen PMCC significantly reduced the levels of anaerobic bacteria
(P = .002). No differences in the reduction of mutans streptococci (P = .187) and
anaerobes (P = .564) were observed between groups. The clinical success rates were
85.71% (Callen PMCC), 78.57% (chlorexidine gel), and 77.77% (one-visit treatment).
CONCLUSION: Teeth treated with Callen PMCC presented the highest clinical success
rate. The 1% chlorhexidine gel, as well as calcium hydroxide/camphorated
paramonochlorophenol, presented limited efficacy in reducing bacteria from necrotic
primary root canals. (Quintessence Int 2013;44:113-122)
AN - rayyan-563562561
AU - Lima, R. A.
AU - de Carvalho, C. B. M.
AU - Ribeiro, T. R.
AU - Fonteles, C. S. R.
DO - 10.3290/j.qi.a28932
IS - 2
PY - 2013
SN - ["0033-6572", "1936-7163"]
SP - 113-122
paramonochlorophenol on infected primary molars: A split-mouth randomized clinical
trial
trial
VL - 44
Y2 - 2
ID - 15935
ER -
TY - JOUR
AN - rayyan-563561932
AU - Lima, R. A.
AU - De Carvalho, C. B. M.
AU - Ribeiro, T. R.
AU - Sá Roriz Fonteles, C.
DO - 10.3290/j.qi.a28932
IS - 2
PY - 2013
SP - 113-122
trial
T2 - Quintessence International
trial
84892862398&doi=10.3290%2fj.qi.a28932&partnerID=40&md5=97628f4fa68d256ae86aab19ab0f
a0ef
VL - 44
ID - 15306
ER -
TY - JOUR
AB - Interleukin-1 beta (IL-1 beta) is a potent regulator of osteoprogenitor cells
and fibroblasts, and is believed to be responsible for the bone loss and connective
tissue breakdown that occurs in periodontitis. Decorin, a major small proteoglycan
in the periodontium, has been shown as an important mediator of the organization of
the pericellular and extracellular matrix. Since the HPLF play a significant role
in the regulation of extracellular matrix metabolism, it was important to clarify
the causal relationship between cytokines, HPLF and proteoglycans. We investigated
the effect of IL-1 beta on decorin gene expression and its functional regulation to
elucidate the intracellular mechanism mediating the action of IL-1 beta.
Quiescently confluent HPLF cultures were incubated for different treatment periods
with various concentrations of IL-1 beta and/or 10(-4) M cycloheximide (Cx) in
culture medium supplemented with 1% charcoal-stripped serum for different treatment
periods. Northern hybridization analyses, using decorin cDNA probe, showed that IL-
1 beta increased the abundance of decorin mRNA in both a dose- and time-dependent
manner. Most of the stimulation was blocked by Cx, indicating that the regulation
of decorin gene expression by IL-1 beta may be via an indirect pathway, requiring
new protein synthesis which regulates the promoter. Gel mobility shift analyses
detected the specific DNA binding activity of a nuclear extract of AP-1, but not
NF-kappa B, that could bind to the recognition site of decorin gene promoter
fragments with the increased abundance in IL-1 beta treatment groups. These results
suggest that the increased transcription of decorin gene by HPLF in the presence of
IL-1 beta is mediated at least in part through the interaction of AP-1 with the
decorin gene promoter.
AN - rayyan-563561049
AU - Lin, J. M.
AU - Yamauchi, M.
AU - Sato, S.
IS - 2
KW - complementary DNA
cycloheximide
decorin
DNA
interleukin 1
messenger RNA
proteoglycan
recombinant protein
scleroprotein
article
bone development
cell culture
connective tissue
cytology
DNA probe
dose response
fibroblast
genetics
human
metabolism
Northern blotting
nucleic acid hybridization
osteolysis
pathophysiology
periodontitis
physiology
promoter region
LA - English
PY - 1997
SN - 0022-3484
SP - 225-232
ST - Effects of recombinant interleukin-1 beta on decorin gene expression in human
periodontal ligament fibroblast and its possible transcriptional regulation
TI - Effects of recombinant interleukin-1 beta on decorin gene expression in human
periodontal ligament fibroblast and its possible transcriptional regulation
VL - 32
ID - 14423
ER -
TY - JOUR
AB - Background: Periodontal pathogenic bacteria promote the destruction of
periodontal tissues and cause loosening and loss of teeth in adults. However,
complete removal of periodontal pathogenic bacteria, at both the bottom of the
periodontal pocket and the root bifurcation area, remains challenging. In this
work, we explored a synergistic antibiotic and photothermal treatment, which is
considered an alternative strategy for highly efficient periodontal antibacterial
therapy. Methods: Mesoporous silica (MSN5) on the surface of Au nanobipyramids (Au
NBPs) were designed to achieve the sustained release of the drug and photothermal
antibacterials. The mesoporous silica-coated Au NBPs (Au NBPs@SiO2) were mixed with
gelatin methacrylate (Ge1MA-Au NBPs@SiO2). Au NBPs@SiO2 and Ge1MA-Au NBPs@SiO2
hybrid hydrogels were characterized, and the drug content and photothermal
properties in terms of the release profile, bacterial inhibition, and cell growth
were investigated. Results: The Ge1MA-Au NBPs@SiO2 hybrid hydrogels showed
controllable minocycline delivery, and the drug release rates increased under 808
nm near-infrared (NIR) light irradiation. The hydrogels also exhibited excellent
antibacterial properties, and the antibacterial efficacy of the antibiotic and
photothermal treatment was as high as 90% and 66.7% against Porphyromonas
gingivalis (P. gingivalis), respectively. Moreover, regardless of NIR irradiation,
cell viability was over 80% and the concentration of Au NBPs@SiO2 in the hybrid
hydrogels was as high as 100 ug/mL. Conclusion: We designed a new near-infrared
light (NIR)-activated hybrid hydrogel that offers both sustained release of
antibacterial drugs and photothermal treatment. Such sustained release pattern
yields the potential to rapidly eliminate periodontal pathogens in the periodontal
pocket, and the photothermal treatment maintains low bacterial retention after the
drug treatment.
AN - rayyan-563562186
AU - Lin, J.
AU - He, Z. Q.
AU - Liu, F.
AU - Feng, J.
AU - Huang, C. Y.
AU - Sun, X. L.
AU - Deng, H.
DO - 10.2147/IJN.S248538
PY - 2020
SN - 1178-2013
SP - 5377-5387
ST - Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with
Sustained Drug Release and NIR-Responsive Photothermal Effect
T2 - INTERNATIONAL JOURNAL OF NANOMEDICINE
TI - Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with
Sustained Drug Release and NIR-Responsive Photothermal Effect
VL - 15
ID - 15560
ER -
TY - JOUR
AB - Background: Periodontal pathogenic bacteria promote the destruction of
periodontal tissues and cause loosening and loss of teeth in adults. However,
complete removal of periodontal pathogenic bacteria, at both the bottom of the
periodontal pocket and the root bifurcation area, remains challenging. In this
work, we explored a synergistic antibiotic and photothermal treatment, which is
considered an alternative strategy for highly efficient periodontal antibacterial
therapy. Methods: Mesoporous silica (MSNs) on the surface of Au nanobipyramids (Au
NBPs) were designed to achieve the sustained release of the drug and photothermal
antibacterials. The mesoporous silica-coated Au NBPs (Au NBPs@SiO2) were mixed with
gelatin methacrylate (GelMA-Au NBPs@SiO2). Au NBPs@SiO2 and GelMA-Au NBPs@SiO2
hybrid hydrogels were characterized, and the drug content and photothermal
properties in terms of the release profile, bacterial inhibition, and cell growth
were investigated. Results: The GelMA-Au NBPs@SiO2 hybrid hydrogels showed
controllable minocycline delivery, and the drug release rates increased under 808
nm near-infrared (NIR) light irradiation. The hydrogels also exhibited excellent
antibacterial properties, and the antibacterial efficacy of the antibiotic and
photothermal treatment was as high as 90% and 66.7% against Porphyromonas
gingivalis (P. gingivalis), respectively. Moreover, regardless of NIR irradiation,
cell viability was over 80% and the concentration of Au NBPs@SiO2 in the hybrid
hydrogels was as high as 100 µg/mL. Conclusion: We designed a new near-infrared
light (NIR)-activated hybrid hydrogel that offers both sustained release of
antibacterial drugs and photothermal treatment. Such sustained release pattern
yields the potential to rapidly eliminate periodontal pathogens in the periodontal
pocket, and the photothermal treatment maintains low bacterial retention after the
drug treatment.
AN - rayyan-563560145
AU - Lin, J.
AU - He, Z.
AU - Liu, F.
AU - Feng, J.
AU - Huang, C.
AU - Sun, X.
AU - Deng, H.
DO - 10.2147/IJN.S248538
KW - laser
gelatin
gold nanobipyramid
gold nanoparticle
hydrogel
methacrylic acid
minocycline
silicon dioxide
unclassified drug
article
cell growth
cell viability
controlled study
cytotoxicity
drug efficacy
in vitro study
irradiation
near infrared light irradiation
nonhuman
synthesis
LA - English
PY - 2020
SN - ["1178-2013", "1176-9114"]
SP - 5377-5387
ST - Hybrid hydrogels for synergistic periodontal antibacterial treatment with
sustained drug release and NIR-responsive photothermal effect
T2 - Int. J. Nanomed.
TI - Hybrid hydrogels for synergistic periodontal antibacterial treatment with
sustained drug release and NIR-responsive photothermal effect
VL - 15
ID - 13519
ER -
TY - JOUR
AN - rayyan-563561992
AU - Lin, S. J.
AU - Chen, C. S.
AU - Lin, S. S.
AU - Chou, M. Y.
AU - Shih, H. C.
AU - Lee, I. P.
AU - Kao, C. T.
AU - Ho, C. C.
AU - Chen, F. L.
AU - Ho, Y. C.
AU - Hsieh, K. H.
AU - Huang, C. R.
AU - Yang, C. C.
DO - 10.1016/j.fct.2006.07.010
IS - 12
PY - 2006
SP - 2078-2085
ST - In vitro anti-microbial and in vivo cytokine modulating effects of different
prepared Chinese herbal medicines
T2 - Food and Chemical Toxicology
TI - In vitro anti-microbial and in vivo cytokine modulating effects of different
prepared Chinese herbal medicines
33749547234&doi=10.1016%2fj.fct.2006.07.010&partnerID=40&md5=17ad77a575708d58c043e4
5b621564e7
VL - 44
ID - 15366
ER -
TY - JOUR
AB - Treating periodontal diseases is a great challenge owing to the motion and
wet conditions, bacterial infection, and tissue defects. Therefore, designing
bioactive materials with outstanding wet-tissue adhesion, antimicrobial features,
as well as favorable cell responses, is highly desirable to meet practical
necessity. In this work, bio-multifunctional melatonin-loaded carboxymethyl
chitosan/polyaldehyde dextran (CPM) hydrogels have been developed through the
dynamic Schiff-base reaction. Our results demonstrate that the CPM hydrogels
display injectability, structural stability, and high tissue adhesion in the wet
and motional state, as well as self-healing features. In addition, the designed
hydrogels show great antibacterial properties and excellent biocompatibility. The
prepared hydrogels display a slow release of melatonin. Moreover, the in vitro
cellular assay indicates that the developed hydrogels containing 10 mg per mL
melatonin significantly promote cell migration. Thus, the synthesized bio-
multifunctional hydrogels show great promise in the treatment of periodontal
disease.
AN - rayyan-563561225
AU - Lin, X.
AU - Lv, J.
AU - Wang, D.
AU - Liu, K.
DO - 10.1039/d3ra00904a
IS - 18
J2 - RSC Adv
LA - eng
N1 - Department of Pharmacy, Qilu Hospital (Qingdao), Cheeloo College of Medicine,
Shandong University Qingdao Shandong China.; Department of Prosthodontics, Qilu
Hospital, Cheeloo College of Medicine, Institute of Stomatology, Shandong
University Jinan Shandong China.; Jinan Stomatological Hospital Jinan Shandong
China.; Department of Stomatology, Qilu Hospital (Qingdao), Cheeloo College of
Medicine, Shandong University Qingdao Shandong China lkkqlyy@163.com.
PY - 2023
SP - 11903-11911
ST - Injectable adhesive carboxymethyl chitosan-based hydrogels with self-mending
and antimicrobial features for the potential management of periodontal diseases
T2 - RSC advances
TI - Injectable adhesive carboxymethyl chitosan-based hydrogels with self-mending
and antimicrobial features for the potential management of periodontal diseases
VL - 13
Y2 - 4 y3 - 17
ID - 14599
ER -
TY - JOUR
AB - Aim: The aim of this systematic review was to evaluate the efficacy of
patient-performed or administered adjunctive measures to non-surgical peri-
implantitis therapy in terms of probing depth (PD) and/or bleeding on probing (BoP)
reductions. Materials and Methods: Randomized and controlled clinical trials with
at least 6 months of follow-up were searched in three databases. Secondary outcomes
included implant loss, disease resolution, recurrence of peri-implantitis, need of
re-treatment, changes in marginal bone levels, patient-reported outcomes and
adverse effects. Results: Of 567 titles, 10 publications, reporting 9
investigations, were included. Three types of adjunctive measures were found
(local/systemic antimicrobials and probiotics). Four studies evaluated the effects
of local antimicrobials (i.e., minocycline microspheres, chlorhexidine chips or a
metronidazole + amoxicillin gel), three studies evaluated systemic antimicrobials
(either amoxicillin + metronidazole or metronidazole alone) and two studies
evaluated probiotics (Lactobacillus reuteri strains). The addition of local
antimicrobials led to modest improvements in PD reduction. Systemic antimicrobials
showed significantly greater reductions in PD and BoP, especially at initially deep
sites (PD > 6 mm). Due to the large heterogeneity among included studies, no meta-
analyses were performed. Conclusions: Different adjunctive measures in the non-
surgical treatment of peri-implantitis have different impact in terms of PD and BoP
reductions. Improved PD reductions result after the use of systemic antimicrobials,
and to a lesser extent, after the use of local antimicrobials.
AN - rayyan-563559703
AU - Liñares, A.
AU - Sanz-Sánchez, I.
AU - Dopico, J.
AU - Molina, A.
AU - Blanco, J.
AU - Montero, E.
DO - 10.1111/jcpe.13821
KW - amlodipine besylate
amoxicillin
antiinfective agent
azithromycin
chlorhexidine
immunoglobulin A
metronidazole
microsphere
minocycline
osteocalcin
probiotic agent
adjuvant therapy
bacterial strain
biofilm
bleeding on probing
bone level
bone remodeling
clinical evaluation
debridement
dental caries
drug efficacy
follow up
graft failure
headache
human
intraocular pressure
Lactobacillus reuteri
meta analysis
mouth hygiene
nonhuman
numeric rating scale
oral bleeding
osteolysis
outcome assessment
patient-reported outcome
paw edema
periimplantitis
periodontitis
plaque index
prevalence
retreatment
review
risk factor
sensitivity analysis
soft tissue inflammation
systematic review
tooth plaque
LA - English
PY - 2023
SN - ["1600-051X", "0303-6979"]
SP - 224-243
ST - Efficacy of adjunctive measures in the non-surgical treatment of peri-
implantitis: A systematic review
TI - Efficacy of adjunctive measures in the non-surgical treatment of peri-
implantitis: A systematic review
VL - 50
ID - 13077
ER -
TY - JOUR
AB - The purpose of the present study was to investigate the therapeutic effect of
intra-canal application of chlorhexidine on inflammatory root resorption. Dental
pulps from monkey incisors were infected and resealed prior to extraction of the
teeth. Root dentin was mechanically exposed and the teeth were replanted under
aseptic conditions. After 4 weeks, the experimental teeth were dressed with
chlorhexidine gel and resealed. Animals were sacrificed 4 weeks later, and their
jaws prepared for histologic examination. Results showed that both marginal and
apical periodontal inflammation and resorption were reduced in the chlorhexidine-
treated teeth. It was concluded that the use of intra-canal chlorhexidine may be a
useful adjunct in the treatment of inflammatory root resorption, but further human
trials need to be undertaken before its clinical use can be recommended.
AN - rayyan-563561024
AU - Lindskog, S.
AU - Pierce, A. M.
AU - Blomlöf, L.
IS - 4
chlorhexidine
animal
article
drug effect
Macaca
periodontitis
tooth disease
wound healing
LA - English
PY - 1998
SN - 0109-2502
SP - 186-190
ST - Chlorhexidine as a root canal medicament for treating inflammatory lesions in
the periodontal space
T2 - Endod Dent Traumatol
TI - Chlorhexidine as a root canal medicament for treating inflammatory lesions in
the periodontal space
VL - 14
ID - 14398
ER -
TY - JOUR
AB - This study investigated the antimicrobial effects of a mouthwash containing
propolis and the effect of a propolis paste formulation on dental healing after
teeth extraction in patients with periodontal disease. In the mouthwash experience,
the population comprised 40 patients, which were divided as follows: the control
mouthwash, 0.2% chlorhexidine (v/v) mouthwash, 2% (w/v) propolis mouthwash, and
propolis + chlorhexidine mouthwash. The study of the propolis paste comprised a
population of 60 patients with periodontal disease, and a total of 120 symmetric
tooth extractions were performed. Propolis showed antimicrobial activity by itself,
and especially with the chlorhexidine association. Three days after surgery in the
teeth treated with control paste, only 13.4% had completely healed; however, with
propolis paste, in 90% of the periodontal sockets, healing was complete. In
addition, a reduction in Streptococci mutans and Lactobacilli cfu was observed with
propolis, and especially with the association of chlorhexidine + propolis. Propolis
mouthwash reduced bacterial proliferation, especially in association with
chlorhexidine. Propolis paste is a viable alternative for socket healing after
dental extraction. The knowledge gained from these findings will provide a
foundation for similar propolis therapies in order to improve the healing process
after dental surgery.
AN - rayyan-563562376
AU - Lisbona-Gonzalez, M. J.
AU - Munoz-Soto, E.
AU - Lisbona-Gonzalez, C.
AU - Vallecillo-Rivas, M.
AU - Diaz-Castro, J.
AU - Moreno-Fernandez, J.
DO - 10.3390/plants10081603
IS - 8
PY - 2021
SN - 2223-7747
ST - Effect of Propolis Paste and Mouthwash Formulation on Healing after Teeth
Extraction in Periodontal Disease
T2 - PLANTS-BASEL
TI - Effect of Propolis Paste and Mouthwash Formulation on Healing after Teeth
Extraction in Periodontal Disease
VL - 10
Y2 - 8
ID - 15750
ER -
TY - JOUR
AN - rayyan-563562070
AU - Liu, B.
AU - Payment, S. A.
AU - Soares, R. V.
AU - Oppenheim, F. G.
AU - Offner, G. D.
AU - Fives-Taylor, P.
AU - Troxler, R. F.
DO - 10.1034/j.1600-0765.2002.01005.x
IS - 6
PY - 2002
SP - 416-424
ST - Interaction of human salivary mucin MG2, its recombinant N-terminal region
and a synthetic peptide with Actinobacillus actinomycetemcomitans
TI - Interaction of human salivary mucin MG2, its recombinant N-terminal region
0036885613&doi=10.1034%2fj.1600-
0765.2002.01005.x&partnerID=40&md5=542ed1d72df1fe8c8be0a03a36810970
VL - 37
ID - 15444
ER -
TY - JOUR
AB - The antimicrobial properties of human salivary mucin MG2 against the
periodontal pathogen, Actinobacillus actinomycetemcomitans (A.
actinomycetemcomitans), were investigated using purified MG2, rNMUC7 (a recombinant
polypeptide containing residue 1-144 of MG2) and synthetic peptides PEP1 (residue
1-17) and PEP2 (residue 47-63). MG2 and rNMUC7 bound to A. actinomycetemcomitans
strains SUNY75, SUNY465, SUNY523, 652 and JP2 in a liquid phase binding assay. The
bactericidal activities of rNMUC7, PEP1 and PEP2 against A. actinomycetemcomitans
SUNY523 were examined in a colony forming unit killing assay. The LD50 for rNMUC7
was 9 microM, for PEP2 was 20 microM and PEP1 did not exhibit bactericidal
activity. The primary structure of these polypeptides was analyzed and a direct
relationship between net positive charge and bactericidal activity was found.
Screening of saliva samples from 60 individuals on Western blots probed with an
anti-MG2 antibody against PEP2 revealed that a 20 kDa MG2 fragment was present in
66% of subjects and that this fragment was not present in glandular secretions.
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry of
tryptic peptides derived from the 20 kDa fragment confirmed that this fragment
contained a portion of the amino terminal region of MG2. The present study showed
that the N-terminal region of MG2 and a subdomain within this region are
microbicidal against A. actinomycetemcomitans and that a 20 kDa fragment of MG2
occurs in whole saliva. This suggests that cleavage of MG2 in vivo may produce
fragments with microbicidal properties and that this may represent a novel
mechanism of host defense.
AN - rayyan-563560894
AU - Liu, B.
AU - Rayment, S. A.
AU - Soares, R. V.
AU - Offner, G. D.
AU - Fives-Taylor, P.
AU - Troxler, R. F.
IS - 6
MUC7 protein, human
mucin
recombinant protein
saliva protein
adult
article
bacterial count
chemistry
drug effect
human
isoelectric focusing
mass spectrometry
middle aged
protein binding
saliva
synthesis
Western blotting
LA - English
PY - 2002
SN - 0022-3484
SP - 416-424
ST - Interaction of human salivary mucin MG2, its recombinant N-terminal region
TI - Interaction of human salivary mucin MG2, its recombinant N-terminal region
VL - 37
ID - 14268
ER -
TY - JOUR
AB - OBJECTIVE: To evaluate the therapeutic effects of 2% minocycline
hydrochloride liposome controlled-release gel on the periodontitis in an
established rat periodontitis model. METHODS: Biocompatibility was tested by oral
perfusion sample solution for long-term observation. Minocycline hydrochloride
liposome controlled-release gel was utilized to treat the established rat
periodontitis model. The rats were selected randomly and divided into three groups:
group A (PERIO-treated group), group B (minocycline hydrochloride liposome
controlled-release gel treated group), and group C (negative control group). The
gingival index (GI) and probing depth (PD) were detected, and the number of
mononuclear and broken bone cells were examined after 7, 14, 28, and 56 d. RESULTS:
The minocycline hydrochloride liposome controlled-release gel exhibited excellent
biocompatibility based on weight measure and tissue section evaluation. The rats
with periodontitis demonstrated that GI, PD, and the number of mononuclear and
broken bone cells of group B decreased in 14, 28, and 56 d. Pathological
observation showed that new bones and fibers were formed in group B. CONCLUSION:
Minocycline hydrochloride liposome controlled-release gel improves rat
periodontitis, thereby providing valuable evidence for clinical application.
AN - rayyan-563560464
AU - Liu, D.
AU - Yang, P.
AU - Hu, D.
AU - Liu, F.
IS - 6
liposome
minocycline
animal
periodontics
periodontitis
rat
LA - Chinese
PY - 2013
SN - 1000-1182
SP - 592-596
ST - Minocycline hydrochloride liposome controlled-release gel improves rat
T2 - Hua Xi Kou Qiang Yi Xue Za Zhi
TI - Minocycline hydrochloride liposome controlled-release gel improves rat
VL - 31
ID - 13838
ER -
TY - JOUR
AB - A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with
controlled release of tannic acid (TA) was synthesized using chitosan (CS).
Specifically, the photo-crosslinked CS hydrogel was first obtained and then
immersed in TA solution to generate composite hydrogel film with enhanced
mechanical properties. Subsequently, N-hydroxysuccinimide/1-ethyl-3-(3-
dimethylaminopropyl) carbodiimide based coupling chemistry was used to covalently
crosslink glucose oxidase (GOx) to CS to obtain glucose sensitivity. The
physicochemical properties, including chemical composition, enzyme-related
characteristics, glucose responsiveness, and mechanical strength, were thoroughly
investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory
tests. The results showed that the GOx immobilized on the film surface by covalent
bonding gave better stability than those that were physically adsorbed. In
addition, it could quickly and correspondingly modify its inner pore structure in
response to the glucose stimulus and then control the loaded TA release. Meanwhile,
the TA addition could enhance the film's mechanical properties. The composite
hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and
TNF-alpha production in stimulated macrophages, as well as Porphyromonas gingivalis
growth, demonstrating effective antibacterial and anti-inflammatory activity.
AN - rayyan-563562231
AU - Liu, J. Y.
AU - Liu, H. F.
AU - Jia, Y. L.
AU - Tan, Z. W.
AU - Hou, R. X.
AU - Lu, J.
AU - Luo, D. M.
AU - Fu, X. Y.
AU - Wang, L.
AU - Wang, X. Y.
DO - 10.1080/09205063.2022.2068948
IS - 13
PY - 2022
SN - ["0920-5063", "1568-5624"]
SP - 1644-1663
ST - Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan
hydrogel film for antibacterial and anti-inflammatory therapy
T2 - JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
TI - Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan
VL - 33
Y2 - 8 y3 - 19
ID - 15605
ER -
TY - JOUR
AB - A novel glucose-sensitive drug delivery system with controlled release of
metronidazole was synthesized by using biocompatible photo-crosslinked chitosan
hydrogel film. Specifically, methacrylic anhydride, as photosensitive substance,
was firstly grafted on chitosan molecular chains and then UV irradiation was
applied as the crosslinking method. Glucose sensitivity was endowed by immobilizing
glucose oxidase on the surface of chitosan film. The physicochemical
characteristics including chemical composition, crosslinking degree, mechanical
strength and related enzyme properties were investigated successively. Cytotoxicity
test, drug release and anti-bacterial test were carried out, respectively. The
results show that this photo-crosslinked hydrogel film has good mechanical
properties; meanwhile, the immobilized enzymes bonding capacity and activity can
maintain a relatively high level after surface activation. In addition, this
material possesses better biocompatibility than chemical crosslinked samples.
What's more, it can sense the ambient glucose stimulus, rapidly and correspondingly
adjust its inner pore structure to control the loaded metronidazole release, lead
to an improved antimicrobial activity against Porphyromonas gingivalis under high
glucose concentration. This glucose sensitive hydrogel film may provide a promising
method for diabetic's periodontitis therapy in clinic. (C) 2018 Published by
Elsevier B.V.
AN - rayyan-563562445
AU - Liu, J. Y.
AU - Xiao, Y.
AU - Wang, X. Y.
AU - Huang, L. X.
AU - Chen, Y.
AU - Bao, C. Y.
DO - 10.1016/j.ijbiomac.2018.09.202
PY - 2019
SN - ["0141-8130", "1879-0003"]
SP - 19-28
ST - Glucose-sensitive delivery of metronidazole by using a photo-crosslinked
chitosan hydrogel film to inhibit Porphyromonas gingivalis proliferation
TI - Glucose-sensitive delivery of metronidazole by using a photo-crosslinked
VL - 122
Y2 - 2 y3 - 1
ID - 15819
ER -
TY - JOUR
AB - Objective: Halitosis is a common complaint affecting the majority of the
population. Mouthrinses containing cetylpyridinium chloride (CPC) have been used as
oral hygiene aids to suppress oral malodor. Although the clinical efficacy of these
mouthrinses has been well-documented, the mechanism whereby CPC reduces malodor is
less-well-understood. We hypothesized that CPC suppresses expression of the genes
(mgl and cdl) and enzymes responsible for methyl mercaptan (CH3SH) and hydrogen
sulfide (H2S) production by oral anaerobes associated with halitosis. In this
study, the mgl and cdl expression of Porphyromonas gingivalis and Fusobacterium
nucleatum in the presence of CPC was investigated. Materials and methods: We used a
microdilution method to determine the growth and production of volatile sulfur
compounds (VSCs) by P. gingivalis W83 and F. nucleatum ATCC 10953 in respective
media containing CPC (0.5 μg/mL to 1.5 μg/mL). For metabolic activity, we used an
XTT {2,3-bis(2-methyloxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide}
reduction assay. We used real-time RT-PCR and Western blotting to evaluate the
effect of CPC at sub-MIC levels on mgl and cdl expression at the transcriptional
and enzymatic levels. Results: CPC inhibited the growth of P. gingivalis and F.
nucleatum at MICs of 3 μg/mL and 2 μg/mL, and at MBCs of 6 μg/mL and 3 μg/mL,
respectively. Compared with untreated controls, CPC at 1.5 μg/mL suppressed CH3SH
production of P. gingivalis by 69.84% ± 2.88% and H2S production of F. nucleatum by
82.55% ± 8.36% (p < 0.05) without affecting metabolic activity. Inhibition of mgl
mRNA (81.58% ± 20.33%) and protein (39.15% ± 6.65%) expression in P. gingivalis and
inhibition of cdl mRNA (61.76% ± 13.75%) and protein (64.34% ± 1.62%) expression in
F. nucleatum were also noted (p < 0.05). Conclusion: CPC represents an effective
agent for halitosis reduction by inhibiting the growth and suppressing the
expression of specific genes related to VSC production in anaerobic periodontal
pathogens. © 2013 Published by Elsevier Ltd.
AN - rayyan-563560505
AU - Liu, J.
AU - Ling, J. Q.
AU - Wu, C. D.
DO - 10.1016/j.archoralbio.2013.08.014
IS - 11
hydrogen sulfide
mouthwash
thiol derivative
article
drug effect
F. nucleatum
gene expression
genetics
halitosis
human
metabolism
microbiology
P. gingivalis
tooth plaque
LA - English
PY - 2013
SN - 0003-9969
SP - 1686-1691
ST - Cetylpyridinium chloride suppresses gene expression associated with halitosis
TI - Cetylpyridinium chloride suppresses gene expression associated with halitosis
VL - 58
ID - 13879
ER -
TY - JOUR
AB - A glucose-sensitive antibacterial and anti-inflammatory hydrogel film with
controlled release of tannic acid (TA) was synthesized using chitosan (CS).
Specifically, the photo-crosslinked CS hydrogel was first obtained and then
immersed in TA solution to generate composite hydrogel film with enhanced
mechanical properties. Subsequently, N-hydroxysuccinimide/1-ethyl-3-(3-
dimethylaminopropyl) carbodiimide based coupling chemistry was used to covalently
crosslink glucose oxidase (GOx) to CS to obtain glucose sensitivity. The
physicochemical properties, including chemical composition, enzyme-related
characteristics, glucose responsiveness, and mechanical strength, were thoroughly
investigated, followed by the cytotoxicity, antibacterial and anti-inflammatory
tests. The results showed that the GOx immobilized on the film surface by covalent
bonding gave better stability than those that were physically adsorbed. In
addition, it could quickly and correspondingly modify its inner pore structure in
response to the glucose stimulus and then control the loaded TA release. Meanwhile,
the TA addition could enhance the film's mechanical properties. The composite
hydrogel film demonstrated adequate biocompatibility and can inhibit NO, IL-6, and
TNF-α production in stimulated macrophages, as well as Porphyromonas gingivalis
growth, demonstrating effective antibacterial and anti-inflammatory activity.
AN - rayyan-563559914
AU - Liu, J.
AU - Liu, H.
AU - Jia, Y.
AU - Tan, Z.
AU - Hou, R.
AU - Lu, J.
AU - Luo, D.
AU - Fu, X.
AU - Wang, L.
AU - Wang, X.
DO - 10.1080/09205063.2022.2068948
IS - 13
conditioned medium
ELISA kit
spectrometer
1 (3 dimethylaminopropyl) 3 ethylcarbodiimide
chitosan
glucose
glucose oxidase
hydrogel
interleukin 6
n hydroxysuccinimide
nitric oxide
tannin
animal cell
antibiotic therapy
article
biocompatibility
cell viability
controlled study
covalent bond
cross coupling reaction
cross linking
cytotoxicity
diabetic complication
drug stability
drug synthesis
enzyme binding
enzyme immobilization
glucose blood level
hydrogen bond
in vitro study
macrophage
mechanical stress
molecular stability
mouse
nonhuman
periodontitis
physical chemistry
physisorption
pore size
reaction analysis
surface property
tensile strength
ultraviolet irradiation
Young modulus
LA - English
PY - 2022
SN - ["1568-5624", "0920-5063"]
SP - 1644-1663
ST - Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan
T2 - J. Biomater. Sci. Polym. Ed.
TI - Glucose-sensitive delivery of tannic acid by a photo-crosslinked chitosan
VL - 33
ID - 13288
ER -
TY - JOUR
AB - To investigate whether oligomerization domains (NODs) are involved in
Porphyromonas gingivalis-induced interleukin (IL)-6, IL-8, and vascular cell
adhesion molecule (VCAM)-1 expression beyond Toll-like receptors (TLRs), we
investigated the role of NOD1/2 in P. gingivalis-induced IL-6, IL-8, and VCAM-1
expression in human gingival fibroblasts (hGFs) and periodontal ligament cells
(hPDLCs). The mechanism was explored by activation and silence of NODs,
electrophoretic mobility shift assay (EMSA), and pathway blockade assays. Results
showed that P. gingivalis could induce NOD1, NOD2, IL-6, IL-8, and VCAM-1
expression in hGFs and hPDLs at mRNA and protein levels. Activation of NOD1/2 by
agonists could clearly upregulate the expression of these genes, while silence of
NOD1/2 could remarkably attenuate them. EMSA and blockade of NF-κB and
extracellular-signal-regulated kinase (ERK)1/2 pathway assays also verified that
the two pathways were involved in NOD1/2-mediated IL-6, IL-8, and VCAM-1
expression. In conclusion, our findings demonstrated that P. gingivalis induced IL-
6, IL-8, and VCAM-1 expression in hGFs and hPDLCs through NOD1/2-mediated NF-κB and
ERK1/2 signaling pathways beyond TLRs. © 2013 Springer Science+Business Media New
York.
AN - rayyan-563560426
AU - Liu, J.
AU - Wang, Y.
AU - Ouyang, X.
DO - 10.1007/s10753-013-9766-0
IS - 2
KW - caspase recruitment domain protein 15
interleukin 6
interleukin 8
messenger RNA
nucleotide binding oligomerization domain protein
toll like receptor
adult
article
cell level
controlled study
female
fibroblast
gingiva
human
human cell
human tissue
intracellular signaling
male
nonhuman
oligomerization
protein domain
protein expression
protein function
protein induction
protein polymerization
upregulation
young adult
LA - English
PY - 2014
SN - ["0360-3997", "1573-2576"]
SP - 522-533
ST - Beyond toll-like receptors: Porphyromonas gingivalis induces IL-6, IL-8, and
VCAM-1 expression through NOD-mediated NF-κB and ERK signaling pathways in
T2 - Inflammation
TI - Beyond toll-like receptors: Porphyromonas gingivalis induces IL-6, IL-8, and
VCAM-1 expression through NOD-mediated NF-κB and ERK signaling pathways in
VL - 37
ID - 13800
ER -
TY - JOUR
AB - A novel glucose-sensitive drug delivery system with controlled release of
metronidazole was synthesized by using biocompatible photo-crosslinked chitosan
hydrogel film. Specifically, methacrylic anhydride, as photosensitive substance,
was firstly grafted on chitosan molecular chains and then UV irradiation was
applied as the crosslinking method. Glucose sensitivity was endowed by immobilizing
glucose oxidase on the surface of chitosan film. The physicochemical
characteristics including chemical composition, crosslinking degree, mechanical
strength and related enzyme properties were investigated successively. Cytotoxicity
test, drug release and anti-bacterial test were carried out, respectively. The
results show that this photo-crosslinked hydrogel film has good mechanical
properties; meanwhile, the immobilized enzyme's bonding capacity and activity can
maintain a relatively high level after surface activation. In addition, this
material possesses better biocompatibility than chemical crosslinked samples.
What's more, it can sense the ambient glucose stimulus, rapidly and correspondingly
adjust its inner pore structure to control the loaded metronidazole release, lead
to an improved antimicrobial activity against Porphyromonas gingivalis under high
glucose concentration. This glucose sensitive hydrogel film may provide a promising
method for diabetic's periodontitis therapy in clinic.
AN - rayyan-563560200
AU - Liu, J.
AU - Xiao, Y.
AU - Wang, X.
AU - Huang, L.
AU - Chen, Y.
AU - Bao, C.
DO - 10.1016/j.ijbiomac.2018.09.202
KW - chitosan
glucose oxidase
metronidazole
animal cell
article
biocompatibility
broth dilution
cell structure
cell viability
colony forming unit
controlled study
cross linking
Gram negative infection
hydrogel
nonhuman
optical density
photosensitivity
polymerization
tensile strength
Young modulus
LA - English
PY - 2019
SN - ["1879-0003", "0141-8130"]
SP - 19-28
ST - Glucose-sensitive delivery of metronidazole by using a photo-crosslinked
TI - Glucose-sensitive delivery of metronidazole by using a photo-crosslinked
VL - 122
ID - 13574
ER -
TY - JOUR
AB - Oral and maxillofacial diseases have an important impact on local function,
facial appearance, and general health. As a multifunctional platform, hydrogels are
widely used in the biomedical field due to their excellent physicochemical
properties. In recent years, a large number of studies have been conducted to adapt
hydrogels to the complex oral and maxillofacial environment by modulating their
pore size, swelling, degradability, stimulus-response properties, etc. Meanwhile,
many studies have attempted to use hydrogels as drug delivery carriers to load
drugs, cytokines, and stem cells for antibacterial, anticancer, and tissue
regeneration applications in oral and maxillofacial regions. This paper reviews the
application and research progress of hydrogel-based drug delivery systems in the
treatment of oral and maxillofacial diseases such as caries, endodontic diseases,
periodontal diseases, maxillofacial bone diseases, mucosal diseases, oral cancer,
etc. The characteristics and applications of hydrogels and drug-delivery systems
employed for the treatment of different diseases are discussed in order to provide
a reference for further research on hydrogel drug-delivery systems in the future.
AN - rayyan-563562461
AU - Liu, L. J.
AU - Wu, D.
AU - Tu, H.
AU - Cao, M. J.
AU - Li, M. X.
AU - Peng, L.
AU - Yang, J.
DO - 10.3390/gels9020146
IS - 2
PY - 2023
SN - 2310-2861
ST - Applications of Hydrogels in Drug Delivery for Oral and Maxillofacial
Diseases
T2 - GELS
TI - Applications of Hydrogels in Drug Delivery for Oral and Maxillofacial
Diseases
VL - 9
Y2 - 2
ID - 15835
ER -
TY - JOUR
AB - Oral and maxillofacial diseases have an important impact on local function,
facial appearance, and general health. As a multifunctional platform, hydrogels are
widely used in the biomedical field due to their excellent physicochemical
properties. In recent years, a large number of studies have been conducted to adapt
hydrogels to the complex oral and maxillofacial environment by modulating their
pore size, swelling, degradability, stimulus-response properties, etc. Meanwhile,
many studies have attempted to use hydrogels as drug delivery carriers to load
drugs, cytokines, and stem cells for antibacterial, anticancer, and tissue
regeneration applications in oral and maxillofacial regions. This paper reviews the
application and research progress of hydrogel-based drug delivery systems in the
treatment of oral and maxillofacial diseases such as caries, endodontic diseases,
periodontal diseases, maxillofacial bone diseases, mucosal diseases, oral cancer,
etc. The characteristics and applications of hydrogels and drug-delivery systems
employed for the treatment of different diseases are discussed in order to provide
a reference for further research on hydrogel drug-delivery systems in the future.
AN - rayyan-563560945
AU - Liu, L.
AU - Wu, D.
AU - Tu, H.
AU - Cao, M.
AU - Li, M.
AU - Peng, L.
AU - Yang, J.
DO - 10.3390/gels9020146
IS - 2
J2 - Gels
LA - eng
N1 - State Key Laboratory of Oral Diseases, National Clinical Research Center for
Oral Diseases, Department of Cariology and Endodontics, West China Hospital of
Stomatology, Sichuan University, Chengdu 610041, China.; State Key Laboratory of
Oral Diseases, National Clinical Research Center for Oral Diseases, Department of
Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University,
Chengdu 610041, China.; State Key Laboratory of Oral Diseases, National Clinical
Research Center for Oral Diseases, Department of Cariology and Endodontics, West
China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.; State
Key Laboratory of Oral Diseases, National Clinical Research Center for Oral
Diseases, Department of Cariology and Endodontics, West China Hospital of
Stomatology, Sichuan University, Chengdu 610041, China.; State Key Laboratory of
Oral Diseases, National Clinical Research Center for Oral Diseases, Department of
Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University,
Chengdu 610041, China.; Key Laboratory of Bio-Resource and Eco-Environment of
Ministry of Education, College of Life Sciences, Sichuan University, Chengdu
610065, China.; State Key Laboratory of Oral Diseases, National Clinical Research
Center for Oral Diseases, Department of Cariology and Endodontics, West China
Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
PY - 2023
ST - Applications of Hydrogels in Drug Delivery for Oral and Maxillofacial
Diseases
TI - Applications of Hydrogels in Drug Delivery for Oral and Maxillofacial
Diseases
VL - 9
Y2 - 2 y3 - 9
ID - 14319
ER -
TY - JOUR
AB - Existing local drug delivery systems for periodontitis suffer from poor
antibacterial effect and unsatisfied periodontal regeneration. In this study, a
smart gingipain-responsive hydrogel (PEGPD@SDF-1) was synthesized as an
environmentally sensitive carrier for on-demand drug delivery. The PEGPD@SDF-1
hydrogel was synthesized from polyethylene glycol diacrylate (PEG-DA) based
scaffolds, dithiothreitol (DTT), and a novel designed functional peptide module
(FPM) via Michael-type addition reaction, and the hydrogel was further loaded with
stromal cell derived factor-1 (SDF-1). The FPM exhibiting a structure of anchor
peptide-short antimicrobial peptide (SAMP)anchor peptide could be cleaved by
gingipain specifically, and the SAMP was released out of the hydrogel for
antibacterial effect in response to gingipain. The hydrogel properties were
characterized by scanning electron microscopy (SEM), Fourier transform infrared
spectroscopy (FTIR), swelling ratio analysis, degradation evaluation, and release
curve description of the SAMP and SDF-1. Results in vitro indicated the PEGPD@SDF-1
hydrogel exhibited preferable biocompatibility and could promote the proliferation,
migration, and osteogenic differentiation of periodontal ligament stem cells
(PDLSCs). Antibacterial testing demonstrated that the PEGPD@SDF-1 hydrogel released
the SAMP stressfully in response to gingipain stimulation, thereby strongly
inhibiting the growth of Porphyromonas gingivalis. Furthermore, the study in vivo
indicated that the PEGPD@SDF-1 hydrogel inhibited P. gingivalis reproduction,
created a low-inflammatory environment, facilitated the recruitment of CD90+/CD34-
stromal cells, and induced osteogenesis. Taken together, these results suggest that
the gingipain-responsive PEGPD@SDF-1 hydrogel could facilitate in situ periodontal
tissue regeneration and is a promising candidate for the on-demand local drug
delivery system for periodontitis.
AN - rayyan-563562022
AU - Liu, S. Y.
AU - Wang, Y. N.
AU - Ma, B. J.
AU - Shao, J. L.
AU - Liu, H. R.
AU - Ge, S. H.
DO - 10.1021/acsami.1c08855
IS - 31
PY - 2021
SN - ["1944-8244", "1944-8252"]
SP - 36880-36893
ST - Gingipain-Responsive Thermosensitive Hydrogel Loaded with SDF-1 Facilitates
In Situ Periodontal Tissue Regeneration
T2 - ACS APPLIED MATERIALS & INTERFACES
TI - Gingipain-Responsive Thermosensitive Hydrogel Loaded with SDF-1 Facilitates
VL - 13
Y2 - 8 y3 - 11
ID - 15396
ER -
TY - JOUR
AB - Existing local drug delivery systems for periodontitis suffer from poor
antibacterial effect and unsatisfied periodontal regeneration. In this study, a
smart gingipain-responsive hydrogel (PEGPD@SDF-1) was synthesized as an
environmentally sensitive carrier for on-demand drug delivery. The PEGPD@SDF-1
hydrogel was synthesized from polyethylene glycol diacrylate (PEG-DA) based
scaffolds, dithiothreitol (DTT), and a novel designed functional peptide module
(FPM) via Michael-type addition reaction, and the hydrogel was further loaded with
stromal cell derived factor-1 (SDF-1). The FPM exhibiting a structure of anchor
peptide-short antimicrobial peptide (SAMP)-anchor peptide could be cleaved by
gingipain specifically, and the SAMP was released out of the hydrogel for
antibacterial effect in response to gingipain. The hydrogel properties were
characterized by scanning electron microscopy (SEM), Fourier transform infrared
spectroscopy (FTIR), swelling ratio analysis, degradation evaluation, and release
curve description of the SAMP and SDF-1. Results in vitro indicated the PEGPD@SDF-1
hydrogel exhibited preferable biocompatibility and could promote the proliferation,
migration, and osteogenic differentiation of periodontal ligament stem cells
(PDLSCs). Antibacterial testing demonstrated that the PEGPD@SDF-1 hydrogel released
the SAMP stressfully in response to gingipain stimulation, thereby strongly
inhibiting the growth of Porphyromonas gingivalis. Furthermore, the study in vivo
indicated that the PEGPD@SDF-1 hydrogel inhibited P. gingivalis reproduction,
created a low-inflammatory environment, facilitated the recruitment of CD90+/CD34-
stromal cells, and induced osteogenesis. Taken together, these results suggest that
the gingipain-responsive PEGPD@SDF-1 hydrogel could facilitate in situ periodontal
tissue regeneration and is a promising candidate for the on-demand local drug
delivery system for periodontitis.
AN - rayyan-563559973
AU - Liu, S.
AU - Wang, Y. N.
AU - Ma, B.
AU - Shao, J.
AU - Liu, H.
AU - Ge, S.
DO - 10.1021/acsami.1c08855
IS - 31
antimicrobial cationic peptide
drug carrier
macrogol
polymethacrylic acid derivative
animal
bone development
bone regeneration
cell motion
chemistry
cytology
drug effect
drug release
hydrogel
male
metabolism
periodontitis
stem cell
synthesis
Wistar rat
LA - English
PY - 2021
SN - 1944-8252
SP - 36880-36893
ST - Gingipain-Responsive Thermosensitive Hydrogel Loaded with SDF-1 Facilitates
T2 - ACS Appl Mater Interfaces
TI - Gingipain-Responsive Thermosensitive Hydrogel Loaded with SDF-1 Facilitates
VL - 13
ID - 13347
ER -
TY - JOUR
AB - The purpose of this study was to design silver nanoparticles (AgNPs)
poloxamer thermoreversible gel (AgNPs-PL) and investigate whether this gel could
provide sustained antibacterial activity against Enterococcus faecalis (E.
faecalis) in the root canal. The gels fabricated were characterized in terms of
gelatin temperature, particle size, in-vitro Ag+ release, and elemental content.
Cytotoxicity of AgNPs-PL on primary human periodontal ligament fibroblasts (HPDLFs)
was examined by CCK-8 assay. Characterization of AgNPs-PL gel revealed that it
contained particles existing as large clumps/fused aggregates of different shapes,
with a mean diameter of 21.624 +/- 14.689 nm, exhibited sustained release of Ag+
for 9 days, and non-toxic to HPDLFs at a low dose (4-32 mu g/mL) through 24, 48,
and 72 h exposures. The antibacterial effect of 16 and 32 mu g/mL concentrations of
AgNPs-PL was compared with blank poloxamer gel (PL) and calcium hydroxide (CH)
using three methods: (I) agar counting plate, (II) scanning electron microscope
(SEM) observations, and (III) confocal laser scanning microscope (CLSM) analysis.
AgNPs-PL at the two doses above was more effective than PL and CH in removing E.
faecalis biofilm at 1, 3, 9 days. Thus, AgNPs-PL exhibits strong activity against
E. faecalis and is easy to produce, with a continuous release profile of Ag+.
AgNPs-PL gel may be a candidate for a new root canal disinfection.
AN - rayyan-563562469
AU - Liu, T.
AU - Aman, A.
AU - Ainiwaer, M.
AU - Ding, L.
AU - Zhang, F.
AU - Hu, Q. A.
AU - Song, Y. X.
AU - Ni, Y. H.
AU - Tang, X. N.
DO - 10.1038/s41598-021-92081-7
IS - 1
PY - 2021
SN - 2045-2322
ST - Evaluation of the anti-biofilm effect of poloxamer-based thermoreversible gel
of silver nanoparticles as a potential medication for root canal therapy
TI - Evaluation of the anti-biofilm effect of poloxamer-based thermoreversible gel
VL - 11
Y2 - 6 y3 - 15
ID - 15843
ER -
TY - JOUR
AB - The purpose of this study was to design silver nanoparticles (AgNPs)
poloxamer thermoreversible gel (AgNPs-PL) and investigate whether this gel could
provide sustained antibacterial activity against Enterococcus faecalis (E.
faecalis) in the root canal. The gels fabricated were characterized in terms of
gelatin temperature, particle size, in-vitro Ag+ release, and elemental content.
Cytotoxicity of AgNPs-PL on primary human periodontal ligament fibroblasts (HPDLFs)
was examined by CCK-8 assay. Characterization of AgNPs-PL gel revealed that it
contained particles existing as large clumps/fused aggregates of different shapes,
with a mean diameter of 21.624 ± 14.689 nm, exhibited sustained release of Ag+ for
9 days, and non-toxic to HPDLFs at a low dose (4-32 μg/mL) through 24, 48, and 72 h
exposures. The antibacterial effect of 16 and 32 μg/mL concentrations of AgNPs-PL
was compared with blank poloxamer gel (PL) and calcium hydroxide (CH) using three
methods: (I) agar counting plate, (II) scanning electron microscope (SEM)
observations, and (III) confocal laser scanning microscope (CLSM) analysis. AgNPs-
PL at the two doses above was more effective than PL and CH in removing E. faecalis
biofilm at 1, 3, 9 days. Thus, AgNPs-PL exhibits strong activity against E.
faecalis and is easy to produce, with a continuous release profile of Ag+. AgNPs-PL
gel may be a candidate for a new root canal disinfection.
AN - rayyan-563559982
AU - Liu, T.
AU - Aman, A.
AU - Ainiwaer, M.
AU - Ding, L.
AU - Zhang, F.
AU - Hu, Q.
AU - Song, Y.
AU - Ni, Y.
AU - Tang, X.
DO - 10.1038/s41598-021-92081-7
IS - 1
calcium hydroxide
metal nanoparticle
poloxamer
silver
biofilm
chemistry
dental pulp cavity
drug effect
female
human
male
microbiology
pathogenicity
LA - English
PY - 2021
SN - 2045-2322
SP - 12577
ST - Evaluation of the anti-biofilm effect of poloxamer-based thermoreversible gel
T2 - Sci Rep
TI - Evaluation of the anti-biofilm effect of poloxamer-based thermoreversible gel
VL - 11
ID - 13356
ER -
TY - JOUR
AB - Periodontitis is a chronic inflammatory disease caused by plaque that leads
to alveolar bone resorption. In the treatment of periodontitis, it is necessary to
reduce the bacterial load and promote alveolar bone regeneration. In this study,
zeolitic imidazolate framework-8 (ZIF-8) is used in the treatment of periodontitis,
and an injectable photopolymerizable ZIF-8/gelatin methacryloyl (GelMA) composite
hydrogel (GelMA-Z) is constructed. We confirm that ZIF-8 nanoparticles are
successfully loaded into GelMA, which demonstrates fluidity and
photopolymerizability. GelMA-Z continuously releases Zn2+ and shows good
cytocompatibility. In vitro, GelMA-Z can effectively upregulate the expression of
osteogenesis-related genes and proteins, increase alkaline phosphatase activity,
promote extracellular matrix mineralization by rat bone mesenchymal stem cells, and
exert an obvious antibacterial effect against Porphyromonas gingivalis. In vivo,
GelMA-Z reduces the bacterial load, relieves inflammation and promotes alveolar
bone regeneration in a rat model. The above results show that GelMA-Z has potential
prospects in the treatment of periodontitis. Statement of significance Various
methods have been explored for the treatment of periodontitis. However, current
regiments have difficulty achieving ideal alveolar bone regeneration. In this
study, we constructed a zeolitic imidazolate framework-8 (ZIF-8)/gelatin
methacryloyl (GelMA) composite hydrogel (GelMA-Z). (1) The injectable and
photopolymerizable GelMA-Z showed biocompatibility in vitro and in vivo. (2) GelMA-
Z continually released zinc ions to promote the osteogenic differentiation of bone
mesenchymal stem cells and kill bacteria in vitro. (3) In a rat model, the GelMA-Z
pregel solution was used to fill the periodontal pocket and then crosslinked by UV
exposure. GelMA-Z can stably remain in the periodontal pocket to reduce the
bacterial load, relieve inflammation and promote alveolar bone regeneration. In
conclusion, GelMA-Z has great potential for use in the treatment of periodontitis,
especially in promoting alveolar bone regeneration. (C) 2022 Published by Elsevier
Ltd on behalf of Acta Materialia Inc.
AN - rayyan-563562016
AU - Liu, Y.
AU - Li, T.
AU - Sun, M. L.
AU - Cheng, Z. Q.
AU - Jia, W. Y.
AU - Jiao, K.
AU - Wang, S. R.
AU - Jiang, K. Z.
AU - Yang, Y. H.
AU - Dai, Z. H.
AU - Liu, L. P.
AU - Liu, G. M.
AU - Luo, Y. A.
DO - 10.1016/j.actbio.2022.03.046
PY - 2022
SN - ["1742-7061", "1878-7568"]
SP - 37-48
ST - ZIF-8 modified multifunctional injectable photopolymerizable GelMA hydrogel
for the treatment of periodontitis
TI - ZIF-8 modified multifunctional injectable photopolymerizable GelMA hydrogel
VL - 146
Y2 - 7 y3 - 1
ID - 15390
ER -
TY - JOUR
AB - Periodontitis is a chronic inflammatory disease caused by plaque that leads
to alveolar bone resorption. In the treatment of periodontitis, it is necessary to
reduce the bacterial load and promote alveolar bone regeneration. In this study,
zeolitic imidazolate framework-8 (ZIF-8) is used in the treatment of periodontitis,
and an injectable photopolymerizable ZIF-8/gelatin methacryloyl (GelMA) composite
hydrogel (GelMA-Z) is constructed. We confirm that ZIF-8 nanoparticles are
successfully loaded into GelMA, which demonstrates fluidity and
photopolymerizability. GelMA-Z continuously releases Zn2+ and shows good
cytocompatibility. In vitro, GelMA-Z can effectively upregulate the expression of
osteogenesis-related genes and proteins, increase alkaline phosphatase activity,
promote extracellular matrix mineralization by rat bone mesenchymal stem cells, and
exert an obvious antibacterial effect against Porphyromonas gingivalis. In vivo,
GelMA-Z reduces the bacterial load, relieves inflammation and promotes alveolar
bone regeneration in a rat model. The above results show that GelMA-Z has potential
prospects in the treatment of periodontitis. Statement of significance: Various
methods have been explored for the treatment of periodontitis. However, current
regiments have difficulty achieving ideal alveolar bone regeneration. In this
study, we constructed a zeolitic imidazolate framework-8 (ZIF-8)/gelatin
methacryloyl (GelMA) composite hydrogel (GelMA-Z). (1) The injectable and
photopolymerizable GelMA-Z showed biocompatibility in vitro and in vivo. (2) GelMA-
Z continually released zinc ions to promote the osteogenic differentiation of bone
mesenchymal stem cells and kill bacteria in vitro. (3) In a rat model, the GelMA-Z
pregel solution was used to fill the periodontal pocket and then crosslinked by UV
exposure. GelMA-Z can stably remain in the periodontal pocket to reduce the
bacterial load, relieve inflammation and promote alveolar bone regeneration. In
conclusion, GelMA-Z has great potential for use in the treatment of periodontitis,
especially in promoting alveolar bone regeneration.
AN - rayyan-563559826
AU - Liu, Y.
AU - Li, T.
AU - Sun, M.
AU - Cheng, Z.
AU - Jia, W.
AU - Jiao, K.
AU - Wang, S.
AU - Jiang, K.
AU - Yang, Y.
AU - Dai, Z.
AU - Liu, L.
AU - Liu, G.
AU - Luo, Y.
DO - 10.1016/j.actbio.2022.03.046
KW - alkaline phosphatase assay kit
autoclave
bacterial viability assay kit
BCA protein assay kit
camera
centrifuge
culture medium
laboratory device
microplate reader
orthodontic wire
petri dish
ascorbic acid
beta actin
beta1 integrin
CD3 antibody
CD3 antigen
collagen type 1
complementary DNA
dexamethasone
gelatin
gelatin methacryloyl
hydrogel
lipopolysaccharide
nanoparticle
osteocalcin
receptor type tyrosine protein phosphatase C
unclassified drug
zeolitic imidazolate framework 8
zinc ion
alveolar bone
animal cell
animal experiment
animal model
article
bacterial load
bacterial viability
biocompatibility
bone development
bone mineralization
bone regeneration
controlled study
gingivitis
in vitro study
in vivo study
male
membrane fluidity
nonhuman
ossification
osteoblast
periodontal pocket
periodontitis
polymerization
protein expression
radiation exposure
rat
tooth calculus
upregulation
LA - English
PY - 2022
SN - ["1878-7568", "1742-7061"]
SP - 37-48
ST - ZIF-8 modified multifunctional injectable photopolymerizable GelMA hydrogel
T2 - Acta Biomater.
TI - ZIF-8 modified multifunctional injectable photopolymerizable GelMA hydrogel
VL - 146
ID - 13200
ER -
TY - JOUR
AB - Periodontitis is a chronic inflammatory disease that is considered to be the
main cause of adult tooth loss. Diabetes mellitus (DM) has a bidirectional
relationship with periodontitis. Interleukin-1β (IL-1β) is an important pre-
inflammatory factor, which participates in the pathophysiological process of
periodontitis and diabetes. The interleukin-1 receptor antagonist (IL-1ra) is a
natural inhibitor of IL-1, and the balance between IL-1ra and IL-1β is one of the
main factors affecting chronic periodontitis (CP) and diabetes. The purpose of this
study is to develop a drug carrier that is safe and nontoxic and can effectively
release IL-1ra, which can effectively slow down the inflammation of periodontal
tissues with diabetes, and explore the possibility of lowering the blood sugar of
this drug carrier. Therefore, in this experiment, a temperature-sensitive hydrogel
loaded with IL-1ra was prepared and characterized, and its anti-inflammatory effect
in high-sugar environments in vivo and in vitro was evaluated. The results showed
that the hydrogel could gel after 5 min at 37 °C, the pore size was 5–70 μm, and
the cumulative release of IL-1ra reached 83.23% on the 21st day. Real-time
polymerase chain reaction (qRT-PCR) showed that the expression of IL-1β,
Interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) inflammatory factors
decreased after the treatment with IL-1ra-loaded thermosensitive hydrogel.
Histological evaluation and micro-computed tomography (Micro-CT) showed that IL-
1ra-loaded thermosensitive hydrogel could effectively inhibit periodontal
inflammation and reduce alveolar bone absorption in rats with diabetic
periodontitis. It is worth mentioning that this hydrogel also plays a role in
relieving hyperglycemia. Therefore, the temperature-sensitive hydrogel loaded with
IL-1ra may be an effective method to treat periodontitis with diabetes.
AN - rayyan-563559796
AU - Liu, Y.
AU - Liu, C.
AU - Wang, C.
AU - Zhang, Q.
AU - Qu, X.
AU - Liang, C.
AU - Si, C.
AU - Wang, L.
DO - 10.3390/ijms232213939
IS - 22
KW - micro-CT scanner
drug carrier
glucose
hydrogel
interleukin 1 receptor blocking agent
interleukin 1beta
interleukin 6
alveolar bone
animal cell
animal experiment
animal model
animal tissue
article
biocompatibility
body weight
bone atrophy
cell survival rate
controlled study
diabetes mellitus
drug degradation
drug effect
drug half life
drug release
drug safety
drug synthesis
glucose blood level
hydrogen bond
hyperglycemia
in vitro study
in vivo study
nonhuman
periodontitis
pore size
protein expression
rat
tissue section
urine volume
X ray diffraction
LA - English
PY - 2022
SN - ["1422-0067", "1661-6596"]
ST - Treatment of Periodontal Inflammation in Diabetic Rats with IL-1ra
Thermosensitive Hydrogel
TI - Treatment of Periodontal Inflammation in Diabetic Rats with IL-1ra
Thermosensitive Hydrogel
VL - 23
ID - 13170
ER -
TY - JOUR
AB - The first pathogenic mechanism of Porphyromonas gingivalis, which is mainly
responsible for adult periodontal diseases, is the attachment of fimbriae
appendages to oral epithelial cells. The ability of a subinhibitory concentration
of azithromycin to inhibit the expression of fimbriae in various strains of P.
gingivalis isolated was investigated. A one-eighth subinhibitory concentration of
azithromycin was evaluated in vitro. The antibiotic was active in 75% of P.
gingivalis strains isolated, judged by both electrophoresis and transmission
electron microscopy. The results indicate that the subinhibitory concentration of
azithromycin is capable of blocking the pathogenic mechanism of P. gingivalis in
vitro, and, therefore, can be used in vivo as a treatment for recurrent
periodontitis.
AN - rayyan-563561450
AU - Lo Bue, A. M.
AU - Rossetti, B.
AU - Calì, G.
AU - Nicoletti, G.
AU - Condorelli, F.
DO - 10.1093/jac/40.5.653
IS - 5
J2 - J Antimicrob Chemother
KW - Anti-Bacterial Agents/*pharmacology
Azithromycin/*pharmacology
Bacterial Proteins/biosynthesis
Microscopy, Electron
Porphyromonas gingivalis/*drug effects/growth & development/ultrastructure
LA - eng
N1 - Institute of Microbiology, University of Catania, Italy.
PY - 1997
SN - 0305-7453 (Print)
SP - 653-7
ST - Antimicrobial interference of a subinhibitory concentration of azithromycin
on fimbrial production of Porphyromonas gingivalis
T2 - The Journal of antimicrobial chemotherapy
TI - Antimicrobial interference of a subinhibitory concentration of azithromycin
on fimbrial production of Porphyromonas gingivalis
VL - 40
Y2 - 11
ID - 14824
ER -
TY - JOUR
AN - rayyan-563561199
AU - Loesche, W. J.
AU - Remsberg, N. S.
AU - Kornman, K. S.
KW - chlorhexidine
abstract report
drug therapy
gel
gingivitis
mouth
therapy
LA - English
PY - 1978
SN - 0022-0345
SP - no. 771
ST - Effect of short term topical chlorhexidine gel treatment on gingivitis
T2 - J. DENT. RES.
TI - Effect of short term topical chlorhexidine gel treatment on gingivitis
VL - 57
ID - 14573
ER -
TY - JOUR
AN - rayyan-563561200
AU - Loesche, W. J.
AU - Syed, S. A.
KW - chlorhexidine
abstract report
bacterium
gingivitis
mouth
LA - English
PY - 1978
SN - 0022-0345
SP - No. 772
ST - Effect of short term topical chlorhexidine gel treatment on the bacterial
flora associated with gingivitis
T2 - J. DENT. RES.
TI - Effect of short term topical chlorhexidine gel treatment on the bacterial
flora associated with gingivitis
VL - 57
ID - 14574
ER -
TY - JOUR
AB - The percentage of Streptococcus mutans and Streptococcus sanguis in pooled
occlusal plaque and in pooled approximal plaque following 8 to 10 daily
applications of either an acidulated phosphate fluoride (APF) gel or a placebo gel
was determined. S. mutans averaged about 9% of the colony forming units (CFU) in
the occlusal plaque and 1% of the CFU in the approximal plaque prior to treatment.
S. sanguis accounted for about 5% of the approximal isolates and 8% of the occlusal
isolates prior to treatment. The APF treatment caused a persistent 45 to 75%
reduction in the percentage of S. mutans in the occlusal samples but did not have
an effect on the percentage of S. mutans in the approximal plaque. Great individual
variability in the percentages of S. mutans prevented the demonstration of
significant differences between the APF and placebo group when parametric
statistical tests were employed. When ranking procedures were used, i.e. Kruskal
Wallis, Willcoxon tests, the APF was found to have a specific antimicrobial effect
against S. mutans in the occlusal plaque, but not in the approximal plaque. This
effect was still apparent 12 wk after the last treatment. There was no effect of
the APF on the percentages of S. sanguis in either sample, except at one wk after
treatment, where the approximal samples showed a significant increase. The plaque
and gingivitis scores in the APF group were significantly less than in the placebo
group.
AN - rayyan-563561214
AU - Loesche, W. J.
AU - Syed, S. A.
AU - Murray, R. J.
AU - Mellberg, J. R.
IS - 2
KW - fluoride
fluorophosphate
sodium fluoride
phosphoric acid
placebo
unclassified drug
article
child
clinical trial
controlled study
gel
gingivitis
human
microorganism
normal human
theoretical study
tooth plaque
luride
LA - English
PY - 1975
SN - 0008-6568
SP - 139-155
ST - Effect of topical acidulated phosphate fluoride on percentage of
Streptococcus mutans and Streptococcus sanguis in plaque. II. Pooled occlusal and
pooled approximal samples
T2 - CARIES RES.
TI - Effect of topical acidulated phosphate fluoride on percentage of
Streptococcus mutans and Streptococcus sanguis in plaque. II. Pooled occlusal and
pooled approximal samples
VL - 9
ID - 14588
ER -
TY - JOUR
AN - rayyan-563561963
AU - Lohbauer, U.
AU - Jell, G.
AU - Saravanapavan, P.
AU - Jones, J. R.
AU - Hench, L. L.
DO - 10.4028/0-87849-961-x.435
PY - 2005
SP - 435-438
ST - Antimicrobial treatment of dental osseous defects with silver doped bioglass:
Osteoblast cell response
T2 - Key Engineering Materials
TI - Antimicrobial treatment of dental osseous defects with silver doped bioglass:
34249025746&doi=10.4028%2f0-87849-961-
x.435&partnerID=40&md5=b150747f51b30986731b30cb734b6941
VL - 284
ID - 15337
ER -
TY - CHAP
AB - In dentistry, chronic periodontitis often leads to bone resorption together
with an increasing risk of bacteremia. Bioactive glass has found extensive
application as dental graft material. A successful antimicrobial bactericidal
effect has been shown from the introduction of Ag2O into the glass composition. In
this study, the cytotoxicity of soluble silver, calcium and silica ions on primary
human osteoblasts was investigated by measurements of mitochondrial activity and
neutral red dye uptake. Silver concentrations of 4 - 6 ppm (1 mg/ml cone.) and 6 9
ppm (2 mg/ml cone.) have been measured in complete culture medium. It was found
that the bioactive gel-glass extract with an initial concentration of 1 mg/ml (1 mg
glass per ml of culture medium) has no negative effect, whereas increased gel-glass
concentration of 2 mg/ml seemed to have a toxic effect on the cell viability of
human osteoblasts. It might be concluded that a reduction of the rate of silver
dissolution from the bioactive gel-glass might preserve a maximum cell viability.
AN - rayyan-563562417
AU - Lohbauer, U.
AU - Jell, G.
AU - Saravanapavan, P.
AU - Jones, J. R.
AU - Hench, L. L.
DO - 10.4028/www.scientific.net/KEM.284-286.435
PY - 2005
SN - ["1013-9826", "0-87849-961-X"]
SP - 435-438
ST - Antimicrobial treatment of dental osseous defects with silver doped bioglass:
T2 - BIOCERAMICS 17
TI - Antimicrobial treatment of dental osseous defects with silver doped bioglass:
VL - 284
ID - 15791
ER -
TY - JOUR
AB - In patients presenting mucositis, effective sub-gingival debridement is
crucial to prevent peri-implantitis. The aim of this randomized study was to assess
the three-month (T1) effects of a locally delivered liquid desiccant agent with
molecular hygroscopic properties, in association with manual debridement, at sites
with peri-implant mucositis. Twenty-three patients presenting at least one implant
with no radiographically detectable bone loss, a pocket probing depth (PPD) ≥ 4 mm,
and bleeding on probing (BOP), were included. At baseline (T0), patients were
randomly assigned to receive the aforementioned desiccant agent before debridement
(Test-Group), or a Chlorhexidine 1% disinfectant gel after debridement (Control-
Group). Treatments were repeated after seven and 14 days. Peri-implant soft tissue
assessment [PPD, BOP, Modified Bleeding Index (mBI), Visible Plaque Index (VPI),
and Modified Plaque Index (mPLI)] and microbial sampling were performed at T0 and
T1. At T1 the Test-Group presented significantly greater reductions for BOP, mBI,
VPI, and mPLI. Concerning the deepest sites of the treated implants, both groups
showed statistically significant reductions for BOP and mBI between T0 and T1.
Furthermore, the Test-Group exhibited a significant decrease in anaerobic bacteria.
Despite these valid outcomes, a complete resolution of the inflammatory conditions
was not achieved by any of the groups.
AN - rayyan-563560210
AU - Lombardo, G.
AU - Signoriello, A.
AU - Corrocher, G.
AU - Signoretto, C.
AU - Burlacchini, G.
AU - Pardo, A.
AU - Nocini, P. F.
IS - 2
KW - NCT03858959
dental therapeutic device
peri implant
periodontal probe
surgical probe
syringe
tooth implant
chlorhexidine
chlorhexidine digluconate corsodyl
desiccant
kanamycin
vancomycin
adult
aerobic bacterium
anaerobic bacterium
article
bacterial count
bleeding on probing
clinical article
clinical outcome
controlled study
debridement
DNA damage
DNA extraction
follow up
gel
human
middle aged
Modified Bleeding Index
Modified Plaque Index
mucosa inflammation
multiplex polymerase chain reaction
pilot study
prevalence
priority journal
sampling
soft tissue
Visible Plaque Index
LA - English
PY - 2019
SN - 2079-6382
ST - A topical desiccant agent in association with manual debridement in the
initial treatment of peri-implant mucositis: A clinical and microbiological pilot
study
T2 - Antibiotics
TI - A topical desiccant agent in association with manual debridement in the
initial treatment of peri-implant mucositis: A clinical and microbiological pilot
study
VL - 8
ID - 13584
ER -
TY - JOUR
AB - BACKGROUND AND OBJECTIVE: Several studies have shown an association between
periodontitis and cardiovascular disease (CVD). Atherosclerosis is the major cause
of CVD, and a key event in the development of atherosclerosis is accumulation of
lipoproteins within the arterial wall. Bacteria are the primary etiologic agents in
periodontitis and Porphyromonas gingivalis is the major pathogen in the disease.
Several studies support a role of modified low-density lipoprotein (LDL) in
atherogenesis; however, the pathogenic stimuli that induce the changes and the
mechanisms by which this occur are unknown. This study aims to identify alterations
in plasma lipoproteins induced by the periodontopathic species of bacterium, P.
gingivalis, in vitro. MATERIAL AND METHODS: Plasma lipoproteins were isolated from
whole blood treated with wild-type and gingipain-mutant (lacking either the Rgp- or
Kgp gingipains) P. gingivalis by density/gradient-ultracentrifugation and were
studied using 2-dimensional gel electrophoresis followed by matrix-assisted laser
desorption/ionization mass spectrometry. Porphyromonas gingivalis-induced lipid
peroxidation and antioxidant levels were measured by thiobarbituric acid-reactive
substances and antioxidant assay kits, respectively, and lumiaggregometry was used
for measurement of reactive oxygen species (ROS) and aggregation. RESULTS:
Porphyromonas gingivalis exerted substantial proteolytic effects on the
lipoproteins. The Rgp gingipains were responsible for producing 2 apoE fragments,
as well as 2 apoB-100 fragments, in LDL, and the Kgp gingipain produced an
unidentified fragment in high-density lipoproteins. Porphyromonas gingivalis and
its different gingipain variants induced ROS and consumed antioxidants. Both the
Rgp and Kgp gingipains were involved in inducing lipid peroxidation. CONCLUSION:
Porphyromonas gingivalis has the potential to change the expression of lipoproteins
in blood, which may represent a crucial link between periodontitis and CVD.
AN - rayyan-563560257
AU - Lönn, J.
AU - Ljunggren, S.
AU - Klarström-Engström, K.
AU - Demirel, I.
AU - Bengtsson, T.
AU - Karlsson, H.
DO - 10.1111/jre.12527
IS - 3
KW - adhesin
antioxidant
APOB protein, human
apolipoprotein A1
apolipoprotein B100
argingipain, Porphyromonas gingivalis
cysteine proteinase
lipoprotein
methionine
blood
drug effect
genetics
human
lipid peroxidation
matrix-assisted laser desorption-ionization mass spectrometry
metabolism
microbiology
pathogenicity
periodontitis
LA - English
PY - 2018
SN - 1600-0765
SP - 403-413
ST - Lipoprotein modifications by gingipains of Porphyromonas gingivalis
TI - Lipoprotein modifications by gingipains of Porphyromonas gingivalis
VL - 53
ID - 13631
ER -
TY - JOUR
AB - OBJECTIVE: Compare the efficacy of amine fluoride toothpaste and gel with
chlorhexidine spray in an institutionalised population. BACKGROUND: People who live
in nursing homes have poorer oral hygiene because of their dependency for the basic
activities of daily living as they rely on caregivers. METHODS: Twenty-six people
over 65 years old who had at least four teeth and living in a nursing home. They
were assigned to three groups: A: amine fluoride toothpaste and once a week amine
fluoride gel (Elmex(®) ), B: 0.12% spray-chlorhexidine once a day (Perio-Aid(®) )
and C: brush teeth without toothpaste. The plaque and gingival index of Silness and
Löe, General Oral Health Assessment Index, McLeran and Pfeiffer index were
recorded, and the number of colonies of Streptoccocus mutans and Lactobacillus and
the remineralisation of caries were evaluated using Diagnodent(®). Measurements
were taken at the beginning of the study and after 6 months. RESULTS: Twenty-two
people finished the study. No group showed a statistical difference in the plaque
or gingival index, but there was a tendency to show improvement in the amine
fluoride group. There was also no difference between the number of colonies of
either S. mutans or lactobacillus. There was a significant difference between the
plaque and gingival index and the cognitive status (p=0.0054), along with their
requirement for assistance to perform good oral hygiene (p=0.0001). Both products
remineralised the carious lesions in this period compared with the control group
(p=0.0151). CONCLUSION: The plaque and gingival indices did not improve during the
study, but both products remineralised the previous caries lesions.
AN - rayyan-563560481
AU - López, R. M.
AU - Uribe, M. R.
AU - Rodríguez, B. O.
AU - Casasempere, I. V.
DO - 10.1111/j.1741-2358.2012.00650.x
IS - 2
chlorhexidine
diamine
fluoride
Olaflur
toothpaste
aged
attitude to health
bacterial load
cognition
comparative study
dental caries
tooth plaque
dental procedure
devices
drug effect
female
follow up
geriatric assessment
gingivitis
health
human
Lactobacillus
male
mouth hygiene
nursing home
periodontics
physiology
pilot study
procedures
tooth brushing
very elderly
LA - English
PY - 2013
SN - 1741-2358
SP - 112-118
ST - Comparison between amine fluoride and chlorhexidine with institutionalized
elders: a pilot study
T2 - Gerodontology
TI - Comparison between amine fluoride and chlorhexidine with institutionalized
elders: a pilot study
VL - 30
ID - 13855
ER -
TY - JOUR
AB - Aim: Carvedilol is an antioxidant that decreases inflammation in
periodontitis. The hydrogen peroxide (H2O2) of bleaching gel causes inflammation
and necrosis of the dental pulp. In the present study, we evaluated the anti-
inflammatory potential of carvedilol in the pulp of rats after bleaching. Methods:
The right upper molars of rats received 35% H2O2 (1× 30 minutes), and the left
upper molars were used as the control. Half of the rats received carvedilol gel (1×
10 minutes), forming the following groups: bleached, bleached followed by
carvedilol (bleached+carvedilol), and control. After 2 and 30 days (N = 7 hemi-
maxillae/group), the rats were killed for histological evaluation, and statistical
tests were performed (P < 0.05). Results: After 2 days, the bleached group showed
necrosis in the occlusal third of the coronal pulp, and in the bleached+carvedilol
group, severe inflammation (P > 0.05), both different from the control (P < 0.05).
In the middle third, the bleached group showed severe inflammation, and the
bleached+carvedilol group showed moderate inflammation (P > 0.05), with the only
difference between the bleached and control groups (P < 0.05). In the cervical
third, the bleached group showed moderate inflammation, and the bleached+carvedilol
group showed mild inflammation (P > 0.05). The difference again was only between
the bleached and control groups (P < 0.05). At 30 days, there was no inflammation
and a marked amount of tertiary dentin in bleached teeth (P > 0.05). Conclusion:
Carvedilol gel has the potential of minimizing H2O2 damage, especially in deep
regions of the dental pulp of rats after bleaching.
AN - rayyan-563560219
AU - Louzada, L. M.
AU - Briso, A. L. F.
AU - Benetti, F.
AU - Vieira, L. B.
AU - Jacinto, R. C.
AU - Dezan-Júnior, E.
AU - Cintra, L. T. A.
DO - 10.1111/jicd.12401
IS - 2
animal model
animal tissue
article
controlled study
dental procedure
female
histology
histopathology
inflammation
necrosis
nonhuman
periodontitis
rat
tooth pulp
tooth pulp disease
antioxidant
carvedilol
hydrogen peroxide
LA - English
PY - 2019
SN - ["2041-1626", "2041-1618"]
ST - Anti-inflammatory potential of a carvedilol gel in the pulpal tissue of rats
after dental bleaching: A histopathological evaluation
T2 - J. Investig. Clin. Dent.
TI - Anti-inflammatory potential of a carvedilol gel in the pulpal tissue of rats
after dental bleaching: A histopathological evaluation
VL - 10
ID - 13593
ER -
TY - JOUR
AB - Objective-To evaluate the effectiveness of a topically applied gel containing
essential oils (menthol and thymol) and polyphenolic antioxidants (phloretin and
ferulic acid) for reducing halitosis in dogs. Animals-20 dogs. Procedures-A blinded
crossover clinical trial was conducted. Dogs received a dental cleaning and
examination (periodontal examination including periodontal probing and assessments
of plaque, calculus, and gingivitis). Owners then applied a gel (active or placebo)
to oral soft tissues twice daily for a 4-week period. Teeth of the dogs were
cleaned again, and owners applied the other gel for a 4-week period. Clinicians
scored halitosis immediately after the initial cleaning and at 4 and 8 weeks, and
owners scored halitosis weekly. Results-Halitosis assessment by clinicians revealed
that both groups had improvement in halitosis scores. Two dogs were removed because
of owner noncompliance. In the activeto- placebo group (n = 9), halitosis was
significantly reduced during application of the active gel but increased during
application of the placebo. Seven of 9 owners reported increased halitosis when
treatment was changed from the active gel to the placebo. In the placeboto- active
group (n = 9), halitosis decreased during application of the placebo and continued
to decrease during application of the active gel. Seven of 9 owners reported a
decrease in halitosis with the active gel. Conclusions and Clinical Relevance-An
oral topically applied gel with essential oils and polyphenolic antioxidants
applied daily after an initial professional dental cleaning decreased oral malodor
in dogs.
AN - rayyan-563560441
AU - Low, S. B.
AU - Michael Peak, R.
AU - Smithson, C. W.
AU - Perrone, J.
AU - Gaddis, B.
AU - Kontogiorgos, E.
DO - 10.2460/ajvr.75.7.653
IS - 7
KW - antioxidant
chlorophyll
essential oil
ferulic acid
menthol
phloretin
placebo
thymol
adult
animal experiment
article
clinical assessment
controlled study
dog
gel
gingivitis
halitosis
nonhuman
periodontal examination
scoring system
LA - English
PY - 2014
SN - ["1943-5681", "0002-9645"]
SP - 653-657
ST - Evaluation of a topical gel containing a novel combination of essential oils
and antioxidants for reducing oral malodor in dogs
T2 - Am. J. Vet. Res.
TI - Evaluation of a topical gel containing a novel combination of essential oils
and antioxidants for reducing oral malodor in dogs
VL - 75
ID - 13815
ER -
TY - JOUR
AB - Aim: To investigate the dynamic changes of peri-implant microbiome in
patients with a history of periodontitis and to construct a microbial prediction
model. Materials and methods: The prospective study was performed at one month
(T1), one year (T2) and two years (T3) after restoration. Clinical examinations
[probing depth (PD), bleeding on probing (BOP), suppuration (SUP)], radiographic
examinations and sample collection were conducted at three timepoints. Peri-implant
sulcular fluid (PISF) was collected and analysed by 16S rRNA gene sequencing.
Generalized linear mixed model (GLMM) was used to identify differences. Results:
Totally, 168 subjects were assessed for eligibility. Twenty-two patients were
recruited in the longitudinal study. Eventually, 67 PISF samples from 24 implants
of 12 patients were collected and analysed. Peri-implant microbiome showed
increasing diversity and complexity over time. Disease-associated genera
Porphyromonas, Tannerella, Treponema and Prevotella dramatically increased from T1
to T3. The prediction model for clinical suppuration at T1 showed a high accuracy
of 90%. Conclusion: The dysbiosis of peri-implant microbiome increased with time
during the two-year observation in patients with a history of periodontitis. Genera
of Porphyromonas, Tannerella, Treponema and Prevotella were biomarkers of peri-
implant mucositis. Microbiota at the early stage could predict subsequent microbial
dysbiosis and clinical suppuration.
AN - rayyan-563560014
AU - Lu, H.
AU - Yan, X.
AU - Zhu, B.
AU - Zhang, L.
AU - Feng, X.
AU - Piao, M.
AU - Huang, B.
AU - Wang, X.
AU - Zhang, H.
AU - Wang, Q.
AU - Meng, H.
DO - 10.1111/jcpe.13410
IS - 3
diagnostic kit
gel extraction kit
implant
Integra CP
micro DNA kit
Miseq PE300
sinus probe
amoxicillin
biological marker
calcium phosphate
chlorhexidine
collagen
RNA 16S
Actinomyces
adult
article
bleeding
bone defect
bone mineral
bone regeneration
centrifugation
debridement
DNA extraction
DNA sequencing
dynamics
erythema
female
maintenance therapy
male
microbiome
middle aged
mucosa inflammation
periodontitis
Porphyromonas
radiodiagnosis
root planing
signal transduction
Streptococcus
suppuration
swelling
Tannerella
wound healing
QIAquick
LA - English
PY - 2021
SN - ["1600-051X", "0303-6979"]
SP - 441-454
ST - The occurrence of peri-implant mucositis associated with the shift of
submucosal microbiome in patients with a history of periodontitis during the first
two years
TI - The occurrence of peri-implant mucositis associated with the shift of
submucosal microbiome in patients with a history of periodontitis during the first
two years
VL - 48
ID - 13388
ER -
TY - JOUR
AB - Effective therapeutic system to periodontitis was designed using cross-linked
cyclodextrin metal-organic framework (COF) as carrier for iodine and further
suspended in hydroxyethyl cellulose gel as I2@COF-HEC hydrogel. Inclusion of iodine
within the COF was demonstrated by SR-FTIR spectral and characteristic DSC and TGA
changes. Molecular modelling identified the interaction of iodine with both COF
central cavity and individual cyclodextrin moieties of COF. In vitro results of
study demonstrated that iodine release in artificial saliva from I2@COF-HEC
hydrogel could be extended up to 5 days, which was slower than I2@COF particles.
Using an in vivo rat model of periodontitis, micro-computed tomography of alveolar
bone morphology demonstrated that I2@COF-HEC hydrogel showed similar effects in
decreasing periodontal pocket depth and alveolar bone resorption to minocycline
ointment, a periodontitis antibiotic. The I2@COF-HEC hydrogel is a novel local
delivery device of iodine as a broad spectrum antimicrobial use for treatment of
periodontitis.
AN - rayyan-563562215
AU - Lu, S.
AU - Ren, X. H.
AU - Guo, T.
AU - Cao, Z. Y.
AU - Sun, H. Y.
AU - Wang, C. F.
AU - Wang, F. Y.
AU - Shu, Z. X.
AU - Hao, J. H.
AU - Gui, S. Y.
AU - Lei, C. A. H.
AU - Zhang, J. W.
DO - 10.1016/j.carbpol.2021.118187
PY - 2021
SN - ["0144-8617", "1879-1344"]
ST - Controlled release of iodine from cross-linked cyclodextrin metal-organic
frameworks for prolonged periodontal pocket therapy
TI - Controlled release of iodine from cross-linked cyclodextrin metal-organic
VL - 267
Y2 - 9 y3 - 1
ID - 15589
ER -
TY - JOUR
AB - Effective therapeutic system to periodontitis was designed using cross-linked
cyclodextrin metal-organic framework (COF) as carrier for iodine and further
suspended in hydroxyethyl cellulose gel as I2@COF-HEC hydrogel. Inclusion of iodine
within the COF was demonstrated by SR-FTIR spectral and characteristic DSC and TGA
changes. Molecular modelling identified the interaction of iodine with both COF
central cavity and individual cyclodextrin moieties of COF. In vitro results of
study demonstrated that iodine release in artificial saliva from I2@COF-HEC
hydrogel could be extended up to 5 days, which was slower than I2@COF particles.
Using an in vivo rat model of periodontitis, micro-computed tomography of alveolar
bone morphology demonstrated that I2@COF-HEC hydrogel showed similar effects in
decreasing periodontal pocket depth and alveolar bone resorption to minocycline
ointment, a periodontitis antibiotic. The I2@COF-HEC hydrogel is a novel local
delivery device of iodine as a broad spectrum antimicrobial use for treatment of
periodontitis.
AN - rayyan-563559971
AU - Lu, S.
AU - Ren, X.
AU - Guo, T.
AU - Cao, Z.
AU - Sun, H.
AU - Wang, C.
AU - Wang, F.
AU - Shu, Z.
AU - Hao, J.
AU - Gui, S.
AU - Lei, C.
AU - Zhang, J.
DO - 10.1016/j.carbpol.2021.118187
KW - alveolar bone
animal experiment
animal model
article
bone remodeling
controlled study
cross linking
genetic association
human
in vitro study
in vivo study
male
molecular model
nonhuman
ointment
osteolysis
rat
rat model
saliva
cyclodextrin
hydrogel
minocycline
saliva substitute
LA - English
PY - 2021
SN - 1879-1344
SP - 118187
ST - Controlled release of iodine from cross-linked cyclodextrin metal-organic
TI - Controlled release of iodine from cross-linked cyclodextrin metal-organic
VL - 267
ID - 13345
ER -
TY - COMP
AB - AN0128 is a boron-containing compound with antibacterial and anti-
inflammatory properties. To test its potential effectiveness in treating
periodontal disease, we induced experimental periodontitis in the rat by placing
ligatures and assessed the impact of AN0128 and positive and negative controls by
micro-CT and histologic measurements. The formation of an inflammatory infiltrate
was measured in hematoxylin-and-eosin-stained sections. Daily application of AN0128
(1%) compared with controls reduced bone loss by 38 to 44% (P < 0.05), while
vehicle alone had no effect (P > 0.05). The reduction in bone loss with AN0128 was
similar to that achieved with a NSAID, ketorolac, and Total toothpaste containing
triclosan. AN0128 also reduced the level of gingival inflammation 42% compared with
the ligature only (P < 0.05), whereas vehicle alone had no effect (P > 0.05). The
results indicate that AN0128 significantly reduces the formation of an inflammatory
infiltrate and reduces bone loss, measured histologically and by micro-CT.
AN - rayyan-563561283
AU - Luan, Q.
AU - Desta, T.
AU - Chehab, L.
AU - Sanders, V. J.
AU - Plattner, J.
AU - Graves, D. T.
CY - United States
DO - 10.1177/154405910808700208
ET - 2
J2 - J Dent Res
KW - Alveolar Bone Loss/pathology/prevention & control
Animals
Anti-Infective Agents, Local/therapeutic use
Anti-Inflammatory Agents/*therapeutic use
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
Boranes/*therapeutic use
Coloring Agents
Complex Mixtures/therapeutic use
Dentifrices/therapeutic use
Ethylene Glycols
Fluorescent Dyes
Fluorides/therapeutic use
Gingivitis/pathology/prevention & control
Ketorolac/therapeutic use
Male
Periodontitis/pathology/*prevention & control
Pharmaceutical Vehicles
Pyridines/*therapeutic use
Rats
Rats, Sprague-Dawley
Silicic Acid
Tomography, X-Ray Computed/methods
Toothpastes
Triclosan/therapeutic use
LA - eng
N1 - Department of Periodontology and Oral Biology, Boston University School of
Dental Medicine, Boston, MA 02118, USA.
PY - 2008
SN - 0022-0345 (Print)
SP - 148-52
ST - Inhibition of experimental periodontitis by a topical boron-based
antimicrobial
T2 - Journal of dental research
TI - Inhibition of experimental periodontitis by a topical boron-based
antimicrobial
VL - 87
Y2 - 2
ID - 14657
ER -
TY - JOUR
AB - Purpose: The association of doxycycline (DOX) and autogenous bone on repair
of critical-size defects was evaluated. Materials and Methods: Fifty albino rats
were divided into 5 groups (n = 10). A 5-mm diameter defect was treated with:
control (CO)-blood clot; DOX in Natrosol (NAT)-10% gel; NAT-gel; particulate
autogenous bone (PAB); and PAB + DOX - PAB associated with 10% DOX gel. The animals
were euthanized at 4 and 8 weeks postoperatively. Histomorphometric analysis was
performed to assess the percentage of new bone in the defect area. Statistical
analysis of the results was performed using analysis of variance and the Tukey test
(P < 0.05). Results: The results showed that new bone formation was limited to the
margins of the defect. At 4 and 8 weeks, the group PAB + DOX showed higher bone
formation (38.59% and 47.86%, respectively), with statistical difference in
comparison with the CO (19.52%) at 4 weeks and CO (18.80%), DOX (22.05%), and NAT
(15.89%) at 8 weeks (P < 0.05). Conclusions: The association of 10% DOX with
autogenous bone significantly improved bone healing in critical-size defects.
AN - rayyan-563562622
AU - Lucateli, R. L.
AU - Ferreira, S.
AU - Garcia, I. R.
AU - Camilleri, J.
AU - Mariano, R. C.
DO - 10.1097/ID.0000000000000783
IS - 4
PY - 2018
SN - 1056-6163
SP - 461-466
ST - Doxycycline and Autogenous Bone in Repair of Critical-Size Defects
T2 - IMPLANT DENTISTRY
TI - Doxycycline and Autogenous Bone in Repair of Critical-Size Defects
VL - 27
Y2 - 8
ID - 15996
ER -
TY - JOUR
AB - The anaerobic Gram-negative bacterium Porphyromonas gingivalis is considered
the keystone of periodontitis diseases, a set of inflammatory conditions that
affects the tissues surrounding the teeth. In the recent years, the major virulence
factors exploited by P. gingivalis have been identified and characterized,
including a cocktail of toxins, mainly proteases called gingipains, which promote
gingival tissue invasion. These effectors use the Sec pathway to cross the inner
membrane and are then recruited and transported across the outer membrane by the
type IX secretion system (T9SS). In P. gingivalis, most secreted effectors are
attached to anionic lipopolysaccharides (A-LPS), and hence form a virulence coat at
the cell surface. P. gingivalis produces additional virulence factors to evade host
immune responses, such as capsular polysaccharide, fimbriae and outer membrane
vesicles. In addition to periodontitis, it is proposed that this broad repertoire
of virulence factors enable P. gingivalis to be involved in diverse human diseases
such as rheumatoid arthritis, and neurodegenerative, Alzheimer, and cardiovascular
disorders. Here, we review the major virulence determinants of P. gingivalis and
discuss future directions to better understand their mechanisms of action.
AN - rayyan-563559999
AU - Lunar Silva, I.
AU - Cascales, E.
DO - 10.1016/j.jmb.2021.166836
IS - 7
KW - bacterial toxin
CD4 antigen
CD8 antigen
gamma interferon
gingipain
interleukin 12
interleukin 6
interleukin 8
protein arginine deiminase
proteinase
unclassified drug
virulence factor
Alzheimer disease
anaerobic bacterium
bacterial virulence
cell surface
fimbria
gingival tissue
human
immune evasion
immune response
inner membrane
membrane vesicle
molecular mechanics
mouth flora
nonhuman
pathogenesis
periodontitis
priority journal
protein secretion
review
T lymphocyte
type VI secretion system
LA - English
PY - 2021
SN - ["1089-8638", "0022-2836"]
ST - Molecular Strategies Underlying Porphyromonas gingivalis Virulence
T2 - J. Mol. Biol.
TI - Molecular Strategies Underlying Porphyromonas gingivalis Virulence
VL - 433
ID - 13373
ER -
TY - JOUR
AB - OBJECTIVE: Human parotid histidine-rich-polypeptides (HRPs) are a family of
lowmolecular-weight, cationic polypeptides. HRP-1, HRP-3 and HRP-5 comprise 85%-90%
of the total HRPs and are called major HRPs. There were many researches indicating
the antimicrobial activities of HRPs. Recently, HRPs were reported to have an
inhibitory action on the lipopolysaccharide (LPS) of E. coli, with HRP-5 being the
most effective one among the three major HRPs. Since the LPS of oral gram-negative
bacteria is thought to be one of the important etiological factors during the
development of periodontal diseases, our experiment was aimed to investigate the
neutralizing effect of human parotid HRP-5 on the LPS of anaerobic suspected
periodontal pathogens, which have different chemical structures and biological
activities compared with LPS of aerobic E. coli. METHODS: By using of preparative
acid urea polyacrylamide gel electrophoresis (AU-PAGE), HRP-5 was purified from
parotid saliva collected from healthy adults. Two stains of suspected periodontal
pathogens, Porphyromonas gingivalis (P.g, 47-A) and Fusobacterium nuceatum (F. n,
separated from subgingival plaque of a patient with adult periodontitis) were mass
cultured. After harvested in the midlogarithmic phase, they were washed and
lyophilized. The LPS of dried bacteria were extracted by the modified Westphal hot
phenol-water procedures and purified by the enzyme digestion plus
ultracentrifugation. Limulus test was applied to test the neutralizing effect of
HRP-5 on the LPS-induced gelation of Limulus amoebocyte lysate. In brief, the
standard LPS of E. coli, or extracted LPS of P. g or F. n, was preincubated with
HRP-5 in a tube separately in room temperature for 10 minutes. Then the reagent of
Limulus amoebocyte lysate was added in all the tubes, continued the incubation in
37 degrees C for one hour. After that, the gelation level of every tube was
observed. RESULTS: LPS extracted from P. g and F. n both showed good purity and
strong activities to induce gelation of Limulus amoebocyte lysate. The gelation
induced by LPS (1 ng/ml) of these two anaerobic suspected periodontal pathogens
were weakly inhibited by HRP-5 (10 micrograms/ml), similar to that observed with
standard LPS of E. coli. To get a complete neutralizing effect on LPS, it may be
important to increase the concentration of HRP-5. CONCLUSION: It appeared that HRPs
could neutralize the endotoxic properties of LPS of suspected periodontal
pathogens, therefore may contribute to periodontal health. The present
investigation further confirmed that HRPs are important components of the host non-
immune defense system.
AN - rayyan-563560935
AU - Luo, H.
AU - Huang, N.
AU - Yang, M.
AU - Tang, B.
AU - Wu, Q.
AU - Wang, B.
IS - 5
KW - histidine rich proteins
histidine-rich proteins
lipopolysaccharide
protein
article
drug effect
Escherichia coli
human
in vitro study
microbiology
pathogenicity
periodontal disease
virulence
LA - Chinese
PY - 2000
SN - 1000-1182
SP - 301-303
ST - The neutralizing effect of histidine-rich-polypeptides on LPS from suspected
TI - The neutralizing effect of histidine-rich-polypeptides on LPS from suspected
VL - 18
ID - 14309
ER -
TY - JOUR
AB - OBJECTIVE: Human parotid histidine-rich-polypeptides (HRPs) are a family of
lowmolecular-weight, cationic polypeptides. HRP-1, HRP-3 and HRP-5 comprise 85%-90%
of the total HRPs and are called major HRPs. There were many researches indicating
the antimicrobial activities of HRPs. Recently, HRPs were reported to have an
inhibitory action on the lipopolysaccharide (LPS) of E. coli, with HRP-5 being the
most effective one among the three major HRPs. Since the LPS of oral gram-negative
bacteria is thought to be one of the important etiological factors during the
development of periodontal diseases, our experiment was aimed to investigate the
neutralizing effect of human parotid HRP-5 on the LPS of anaerobic suspected
periodontal pathogens, which have different chemical structures and biological
activities compared with LPS of aerobic E. coli. METHODS: By using of preparative
acid urea polyacrylamide gel electrophoresis (AU-PAGE), HRP-5 was purified from
parotid saliva collected from healthy adults. Two stains of suspected periodontal
pathogens, Porphyromonas gingivalis (P.g, 47-A) and Fusobacterium nuceatum (F. n,
separated from subgingival plaque of a patient with adult periodontitis) were mass
cultured. After harvested in the midlogarithmic phase, they were washed and
lyophilized. The LPS of dried bacteria were extracted by the modified Westphal hot
phenol-water procedures and purified by the enzyme digestion plus
ultracentrifugation. Limulus test was applied to test the neutralizing effect of
HRP-5 on the LPS-induced gelation of Limulus amoebocyte lysate. In brief, the
standard LPS of E. coli, or extracted LPS of P. g or F. n, was preincubated with
HRP-5 in a tube separately in room temperature for 10 minutes. Then the reagent of
Limulus amoebocyte lysate was added in all the tubes, continued the incubation in
37 degrees C for one hour. After that, the gelation level of every tube was
observed. RESULTS: LPS extracted from P. g and F. n both showed good purity and
strong activities to induce gelation of Limulus amoebocyte lysate. The gelation
induced by LPS (1 ng/ml) of these two anaerobic suspected periodontal pathogens
were weakly inhibited by HRP-5 (10 micrograms/ml), similar to that observed with
standard LPS of E. coli. To get a complete neutralizing effect on LPS, it may be
important to increase the concentration of HRP-5. CONCLUSION: It appeared that HRPs
could neutralize the endotoxic properties of LPS of suspected periodontal
pathogens, therefore may contribute to periodontal health. The present
investigation further confirmed that HRPs are important components of the host non-
immune defense system.
AN - rayyan-563561455
AU - Luo, H.
AU - Huang, N.
AU - Yang, M.
AU - Tang, B.
AU - Wu, Q.
AU - Wang, B.
IS - 5
J2 - Hua Xi Kou Qiang Yi Xue Za Zhi
KW - Escherichia coli/*drug effects/pathogenicity
Fusobacterium nucleatum/*drug effects/pathogenicity
Humans
In Vitro Techniques
Lipopolysaccharides/adverse effects
Periodontal Diseases/*microbiology
Proteins/*pharmacology
Virulence
LA - chi
N1 - College of Stomatology, West China University of Medical Sciences.
PY - 2000
SN - 1000-1182 (Print)
SP - 301-3
ST - [The neutralizing effect of histidine-rich-polypeptides on LPS from suspected
periodontal pathogens]
T2 - Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China
journal of stomatology
TI - [The neutralizing effect of histidine-rich-polypeptides on LPS from suspected
periodontal pathogens]
VL - 18
Y2 - 10
ID - 14829
ER -
TY - JOUR
AB - To combat dental caries, a chemical has been sought that possesses stronger
antimicrobial properties than fluoride in support of its physicochemical tooth-
protecting properties. These searches have led to several agents, of which
chlorhexidine (CH) appears most effective. To reduce local side effects of the
well-known 0.2% CH mouthwash, a 0.05% CH gluconate + 0.04% NaF solution, pH 5.9,
has been developed. Use of this combination over a 2-year period resulted in a 53%
reduction in caries increment and a 75% reduction in gingival bleeding, i.e. a
clear duality of prevention of oral disease (Luoma et al. 1978). Staining of teeth
was minimal and easily removable in about one third of the subjects. To lessen the
contribution of patients, chlorhexidine gels, without but more especially with
fluoride have been professionally administered. Reductions in salivary mutans
streptococci after short periods of gel applications have been found to persist
longer than reductions after brief periods of mouthwashing. Reductions of
approximal caries increment by about 50% in children, and root surface caries in
adults have been obtained through use of CH gels. The effect on root surface caries
in adults was equal to that obtained through use of local fluoride applications.
Dental CH varnish seems promising, especially because a very short contact time
with a tooth may be sufficient to reduce mutans streptococci. No simultaneous
effects against caries and gingivitis of CH gels or varnishes has been reported.
Comparisons of CH solutions, gels and varnishes, with or without fluoride, in
relation to their potentials for preventing oral disease in subjects at risk remain
to be accomplished.
AN - rayyan-563561143
AU - Luoma, H.
IS - 3
KW - chlorhexidine
fluoride varnish
paint
comparative study
dental caries
gel
gingivitis
human
mouth hygiene
review
time
tooth discoloration
LA - English
PY - 1992
SN - 0355-4651
SP - 147-153
ST - Chlorhexidine solutions, gels and varnishes in caries prevention
T2 - Proc Finn Dent Soc
TI - Chlorhexidine solutions, gels and varnishes in caries prevention
VL - 88
ID - 14517
ER -
TY - JOUR
AB - Abstract: Phase separation with solvent exchange induced-in situ forming gel
(ISG) is an attractive delivery system for periodontitis treatment. Eudragit® RS-PO
(ERS) in N-methyl pyrrolidone (NMP) was used as polymer matrix for doxycycline
hyclate (DH)-loaded solvent-exchanged ISG; however, a high burst drug release was
evident. The present study revealed the role of PEG 1500 on physicochemical
properties and modification of a burst release for DH-loaded ISG. DH-loaded ISG
system comprising PEG 1500 exhibited the Newtonian flow with acceptable
injectability with PEG 1500 concentration dependence and high in vitro degradation
owing to NMP and PEG 1500 liberation. Solvent exchange between NMP with PBS pH 6.8
conveyed the rapid phase separation of ERS/PEG 1500 as a matrix which the entrapped
DH diffused out gradually. Both dialysis membrane and membrane-less methods proved
the slower drug release of DH-loaded ERS ISG comprising PEG than PEG 1500-free ISG.
SEM revealed the porous matrix topography from polymeric phase separation
especially for higher PEG 1500 loading. PEG 1500 incorporation significantly
decreased the inhibition diameter against S. aureus, E. coli and S. mutans (P <
0.05) indicating the retardation of drug release owing to the high viscosity of the
PEG 1500. PEG 1500-incorporated DH-loaded ERS ISG exhibited the potential use for
periodontitis treatment. Graphical abstract: PEG loading into solvent induced ERS
in situ forming gel for doxycycline hyclate periodontal pocket delivery.[Figure not
available: see fulltext.].
AN - rayyan-563560139
AU - Lwin, W. W.
AU - Puyathorn, N.
AU - Senarat, S.
AU - Mahadlek, J.
AU - Phaechamud, T.
DO - 10.1007/s40005-019-00430-6
IS - 1
KW - dialysis membrane
texture analyzer
1 methyl 2 pyrrolidinone
doxycycline hyclate
eudragit rs
macrogol
proteins by physicochemical property
article
biodegradability
biofilm matrix
bulk density
Candida albicans
chemical reaction
diffusivity
drug release
emulsion
Escherichia coli
flow kinetics
gel formation
human
injectability test
mathematical analysis
periodontitis
pH measurement
phase separation
physical chemistry
plasma viscosity
priority journal
protein degradation
shear rate
shear stress
surface property
topography
viscosity
LA - English
PY - 2020
SN - ["2093-6214", "2093-5552"]
SP - 81-94
ST - Emerging role of polyethylene glycol on doxycycline hyclate-incorporated
Eudragit RS in situ forming gel for periodontitis treatment
TI - Emerging role of polyethylene glycol on doxycycline hyclate-incorporated
Eudragit RS in situ forming gel for periodontitis treatment
VL - 50
ID - 13513
ER -
TY - JOUR
AN - rayyan-563561699
AU - Lyamin, E. S.
AU - Fedorova, Yu S.
AU - Kulpin, P. V.
AU - Suslov, N. I.
AU - Kucheryavyi, D. V.
DO - 10.17816/KMJ2020-25
IS - 1
PY - 2020
SP - 25-30
ST - Comparison between the efficacy plant and synthetic origin dental products in
the treatment of chronic catarrhal gingivitis
T2 - Kazan Medical Journal
TI - Comparison between the efficacy plant and synthetic origin dental products in
the treatment of chronic catarrhal gingivitis
85103568072&doi=10.17816%2fKMJ2020-
25&partnerID=40&md5=9023191e3180b72e05a4e5196b06eb36
VL - 101
ID - 15073
ER -
TY - JOUR
AB - The results of epidemiological studies as well as statistical data show that
in recent years the dental morbidity rate in the world has remained stable at a
high level. Inflammatory diseases of periodontal tissues, in particular generalized
forms of periodontitis, reach 80% in the world. The tendency of increasing the
prevalence rate of these diseases in Ukraine, 60-99%, is being observed nowadays.
AIM: The aim of this study was to examine the antimicrobial activity of three gel-
based medicinal products, being widely used in periodontology: Abigel, an herbal
remedy, containing fir oil and oak bark extract; Fitoron, which contains oak bark
extract, and President gel with chlorhexidine. MATERIALS AND METHODS: Gram-positive
and gram-negative bacteria, belonging to different taxonomic groups: Staphylococcus
aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853,
Bacillus subtilis ATCC 6633 and Proteus vulgaris ATCC 4636, Candida albicans ATCC
885-653, were as a substrate for further examinations. Preparing the suspensions of
microorganisms with a defined optical density of microbial cells was executed using
the turbidity standard (0.5 McFarland standard). The Densi-La-Meter device (made by
"PLIVA-Lachema", Czech Republic; wavelength = 540 nm) was used. The suspension was
prepared in accordance with the device guidance and the information sheet on
innovations in the health care system No. 163-2006 "Standardization of preparation
of microbial suspensions". RESULTS: The highest activity against Staphylococcus
aureus is being observed in President gel with chlorhexidine (24 mm and 25 mm),
followed by Abigel gel (20, 21, 22 mm) and Fitoron has the minimum activity (17 and
18 mm). The growth zone of Bacillus subtilis is maximally inhibited by President
gel with chlorhexidine (25 and 26 mm), Fitoron's inhibition zone is of 23 and 24
mm, and in the last place is Abigel gel - 20 and 21 mm. President gel with
chlorhexidine has a pronounced antifungal effect with the inhibition zone of 20, 21
and 22 mm, Fitoron's inhibition zone is of 19 and 20 mm, and one of Abigel gel - of
16 and 17 mm. Concerning Enterococcus faecalis, the highest activity was
established in President gel with chlorhexidine (the inhibition zone of 22 and 23
mm), Abigel gel had inhibition zone of 20 and 21 mm, whereas one of Fitoron was of
18 and 19 mm. Haemophilus influenzae was maximally influenced by President gel with
chlorhexidine with the inhibition zone of 19 and 20 mm, Abigel gel caused the
growth inhibition by 17 and 18 mm, and the lowest growth inhibition was of Fitoron
- 16 mm. President gel with chlorhexidine (19, 20, 21 mm) and Abigel gel (19 mm)
had almost the same influence on the growth of Streptococcus pyogenes, whereas
these figures of Fitoron were 16 and 17 mm. Abigel gel had a pronounced activity
against Streptococcus mutans with the inhibition zone of 20 mm, one of President
gel with chlorhexidine was of 19 and 20 mm, and of Fitoron - 17 and 18 mm. The
growth of Neisseria sp was maximally inhibited by President gel with chlorhexidine
(18, 19, 20 mm), in the second place was Abigel gel (18, 19 mm) and the lowest
results were of Fitoron (16, 17 mm). CONCLUSIONS: President gel with chlorhexidine,
Fitoron and Abigel gel have pronounced antimicrobial properties as to the testing
cultures of microorganisms under study. Abigel is an effective method of choice in
the conservative treatment of inflammatory periodontal diseases.
AN - rayyan-563559998
AU - Lyubchenko, O. V.
AU - Velihoria, I. E.
AU - Polyakova, S. V.
AU - Ivanov, O. E.
AU - Tzyhanova, N. B.
AU - Pushkar, L. Y.
AU - Sirota, O. M.
AU - Tzyhanova, I. V.
IS - 290
human
periodontal disease
LA - English
PY - 2021
SN - 1426-9686
SP - 125-128
ST - Microbiological aspects of conservative treatment of periodontal disease
using gel-based preparations
T2 - Pol Merkur Lekarski
TI - Microbiological aspects of conservative treatment of periodontal disease
using gel-based preparations
VL - 49
ID - 13372
ER -
TY - JOUR
AB - Bacteria are recognized as the driving factors of periodontitis. However,
excessive reactive oxygen species (ROS) can harm periodontal tissue while also
causing an uncontrolled inflammatory response. Hence, eliminating excessive ROS and
blocking ROS-induced abnormal inflammatory response by antioxidants are achieving
remarkable results in periodontitis therapy. Moreover, influenced by the deep and
irregular periodontal pockets, injectable thermo-sensitive chitosan-based hydrogels
have attracted a lot of attention. This study aimed to formulate an antibacterial
and antioxidant therapeutic regimen by incorporating antimicrobial peptides (Nal-P-
113) and/or antioxidants (polydopamine nanoparticles, PDNPs) into chitosan-based
hydrogels. The hydrogel was characterized in vitro and finally examined in rats
using the experimental periodontitis model. The release ki-netics showed that the
hydrogel could stably release Nal-P-113 and PDNPs for up to 13 days. The scavenging
activity of the hydrogel against DPPH was about 80 % and the antibacterial ratio
against Streptococcus gordonii (S. gordonii), Fusobacterium nucleatum (F.
nucleatum) and Porphyromonas gingivalis (P. gingivalis) was about 99 %.
Importantly, it was examined that the hydrogel had the ability to prevent
periodontal tissue damage. Thus, chitosan-based hydrogels may provide a basis for
designing multifunctional local drug delivery biomaterials for the treatment of
periodontitis.
AN - rayyan-563562011
AU - Ma, S. Q.
AU - Lu, X. M.
AU - Yu, X. Y.
AU - Du, Y. Q.
AU - Xu, S. D.
AU - Li, M. T.
AU - Peng, C.
AU - Liu, Z. H.
AU - Deng, J. Y.
DO - 10.1016/j.bioadv.2022.213158
PY - 2022
SN - 2772-9508
ST - An injectable multifunctional thermo-sensitive chitosan-based hydrogel for
T2 - BIOMATERIALS ADVANCES
TI - An injectable multifunctional thermo-sensitive chitosan-based hydrogel for
VL - 142
Y2 - 11
ID - 15385
ER -
TY - JOUR
AB - Bacteria are recognized as the driving factors of periodontitis. However,
excessive reactive oxygen species (ROS) can harm periodontal tissue while also
causing an uncontrolled inflammatory response. Hence, eliminating excessive ROS and
blocking ROS-induced abnormal inflammatory response by antioxidants are achieving
remarkable results in periodontitis therapy. Moreover, influenced by the deep and
irregular periodontal pockets, injectable thermo-sensitive chitosan-based hydrogels
have attracted a lot of attention. This study aimed to formulate an antibacterial
and antioxidant therapeutic regimen by incorporating antimicrobial peptides (Nal-P-
113) and/or antioxidants (polydopamine nanoparticles, PDNPs) into chitosan-based
hydrogels. The hydrogel was characterized in vitro and finally examined in rats
using the experimental periodontitis model. The release kinetics showed that the
hydrogel could stably release Nal-P-113 and PDNPs for up to 13 days. The scavenging
activity of the hydrogel against DPPH was about 80 % and the antibacterial ratio
against Streptococcus gordonii (S. gordonii), Fusobacterium nucleatum (F.
nucleatum) and Porphyromonas gingivalis (P. gingivalis) was about 99 %.
Importantly, it was examined that the hydrogel had the ability to prevent
periodontal tissue damage. Thus, chitosan-based hydrogels may provide a basis for
designing multifunctional local drug delivery biomaterials for the treatment of
periodontitis.
AN - rayyan-563560808
AU - Ma, S.
AU - Lu, X.
AU - Yu, X.
AU - Du, Y.
AU - Xu, S.
AU - Li, M.
AU - Peng, C.
AU - Liu, Z.
AU - Deng, J.
DO - 10.1016/j.bioadv.2022.213158
J2 - Biomater Adv
KW - Rats
Animals
*Chitosan/chemistry
Hydrogels/chemistry
Antioxidants/pharmacology
Reactive Oxygen Species/therapeutic use
*Periodontitis/drug therapy
Porphyromonas gingivalis/physiology
LA - eng
N1 - Department of Stomotology, The Second Hospital of Tianjin Medical University,
23 Pingjiang Road, Hexi District, Tianjin 300211, China.; School and Hospital of
Stomatology, Tianjin Medical University, 12 Observatory Road, Tianjin 300070,
China.; School and Hospital of Stomatology, Tianjin Medical University, 12
Observatory Road, Tianjin 300070, China.; School and Hospital of Stomatology,
Tianjin Medical University, 12 Observatory Road, Tianjin 300070, China.; School and
Hospital of Stomatology, Tianjin Medical University, 12 Observatory Road, Tianjin
300070, China.; School and Hospital of Stomatology, Tianjin Medical University, 12
Observatory Road, Tianjin 300070, China.; Department of Stomotology, The Second
Hospital of Tianjin Medical University, 23 Pingjiang Road, Hexi District, Tianjin
300211, China.; School and Hospital of Stomatology, Tianjin Medical University, 12
Observatory Road, Tianjin 300070, China. Electronic address: liuzihao@tmu.edu.cn.;
School and Hospital of Stomatology, Tianjin Medical University, 12 Observatory
Road, Tianjin 300070, China. Electronic address: jdeng@tmu.edu.cn.
PY - 2022
SP - 213158
ST - An injectable multifunctional thermo-sensitive chitosan-based hydrogel for
T2 - Biomaterials advances
TI - An injectable multifunctional thermo-sensitive chitosan-based hydrogel for
VL - 142
Y2 - 11
ID - 14182
ER -
TY - JOUR
AB - Macrophages are highly implicated in the progression of periodontitis, while
circadian rhythm disruption (CRD) promotes the inflammatory response of macrophages
in many diseases. However, the effects of CRD on periodontitis and the role of
macrophages in this process remain unclear. Histone lysine demethylase 6a (Kdm6a),
a histone demethylase, has recently been identified as a key regulator of
macrophage-induced inflammation. Here, we established an experimental periodontitis
model by injecting lipopolysaccharide (LPS) derived from Porphyromonas gingivalis
with or without periodontal ligation in mice exposed to an 8-h time shift jet-lag
schedule every 3 days. By histomorphometry, tartrate acid phosphatase (TRAP)
staining, RT-qPCR, ELISA, immunohistochemistry and immunofluorescence analysis, we
found that CRD promoted the inflammatory response, alveolar bone resorption,
macrophage infiltration and Kdm6a expression in macrophages. Macrophage-specific
Kdm6a knockout mice were further used to elucidate the effects of Kdm6a deficiency
on periodontitis. Kdm6a deletion in macrophages rescued periodontal tissue
inflammation, osteoclastogenesis, and alveolar bone loss in a mouse model of
periodontitis. These findings suggest that CRD may intensify periodontitis by
increasing the infiltration and activation of macrophages. Kdm6a promotes the
inflammatory response in macrophages, which may participate in aggravated
periodontitis via CRD.
AN - rayyan-563559741
AU - Ma, X.
AU - Chen, X.
AU - Duan, Z.
AU - Wu, Y.
AU - Shu, J.
AU - Wu, P.
AU - Zhao, Y.
AU - Wang, X.
AU - Wang, Y.
DO - 10.1016/j.intimp.2023.109796
KW - ChamQ SYBR qPCR Master Mix
CT scanner software
ELISA kit
enzyme test kit
Hiscript II
imaging software
micro-CT scanner
NRecon
Skyscan1176
spectrophotometer
histone demethylase
histone lysine demethylase 6a
interleukin 1beta
interleukin 6
unclassified drug
alveolar bone loss
animal cell
animal experiment
animal model
animal tissue
article
bone remodeling
C57BL/6N mouse
cell infiltration
circadian rhythm
controlled study
gingival tissue
inflammatory cell
jet lag
macrophage
male
molecular pathology
morphometry
mouse
multinuclear cell
nonhuman
osteoclast
osteoclastogenesis
osteolysis
protein blood level
second molar
upregulation
ABI 7500
BX51
ImageJ
NanoDrop
LA - English
PY - 2023
SN - ["1878-1705", "1567-5769"]
ST - Circadian rhythm disruption exacerbates the progression of macrophage
dysfunction and alveolar bone loss in periodontitis
T2 - Int. Immunopharmacol.
TI - Circadian rhythm disruption exacerbates the progression of macrophage
dysfunction and alveolar bone loss in periodontitis
VL - 116
ID - 13115
ER -
TY - JOUR
AB - To observe the effect of the self-made chitosan thermosensitive hydrogel
system with dual-release bone morphogenetic protein and chlorhexidine on
periodontal defects repair. The furcation defect model was established on dog
premolar. The models were divided into five groups, including three experimental
groups, one control group and one blank control group. The hydrogel with the
chlorhexidine/3-cyclodextrin inclusion complexes (IC) /rhBMP-2, hydrogel with
rhBMP-2, hydrogel with IC, the pure hydrogel were applied to the defects of the
four groups, respectively, and the blank control group did not receive any agent.
The dogs were sacrificed 8 weeks later and the periodontal regeneration and
gingival condition were observed by histological examination. Obvious periodontal
tissue regeneration was found in group one and two. The heights of new bone reached
99.2% of the defects in group one, 87.8%, 63.6%, 37.0% and 34.3% in group two,
three, four and blank control groups, respectively. The inflammation of the
affected gingiva showed less significant in group one and group three than in the
other groups. rhBMP-2 and chlorhexidine played their independent role in repairing
periodontal defects and the dual-release chitosan thermosensitive hydrogel system
is effective and convenient to use.
AN - rayyan-563560712
AU - Ma, Z. W.
AU - Zhang, Y. J.
AU - Wang, R.
AU - Wang, Q. T.
AU - Dong, G. Y.
AU - Wu, Z. F.
IS - 5
KW - bone morphogenetic protein
chitosan
chlorhexidine
animal
article
dog
drug effect
hydrogel
male
periodontium
physiology
regeneration
tissue engineering
LA - Chinese
PY - 2008
SN - 1002-0098
SP - 273-277
ST - [An animal experiment for the regeneration of periodontal defect by
application of the dual-release chitosan thermosensitive hydrogel system]
TI - [An animal experiment for the regeneration of periodontal defect by
application of the dual-release chitosan thermosensitive hydrogel system]
VL - 43
ID - 14086
ER -
TY - JOUR
AB - Purpose: The purpose of this study was to evaluate chlorhexidine to control
gingivitis and Candida species (spp.) in children infected with the human
immunodeficiency virus (HIV) and their acceptance of the therapy. Methods: Twenty-
six HIV+ children were selected, and oral exam-established biofilm, gingival
indexes, and stimulated saliva were collected for Candida ssp. identification. The
children brushed their teeth for 21 days with chlorhexidine gel (0.2%). Salivary
samples, biofilm, and gingival indexes were collected after 21-days and again 35
days after ceasing gel use. The children answered a questionnaire about the
therapy. Results: All children tested positive for Candida and gingivitis. After 21
days, Candida counts and gingivitis decreased in 25 and 26 children, respectively.
Mean reduction was approximately 68% for Candida spp. and 74% for gingivitis.
Thirty-five days after discontinuing gel use, gingivitis and Candida spp. increased
in 13 and 16 patients, respectively. Considering the Candida spp., the heavy growth
was lower in the first re-evaluation. Candida albicans was the most frequent
species. Approximately 85% did not experience inconvenience with the gel, and
approximately 48% thought it was good for tooth-brushing. Conclusion: Chlorhexidine
therapy may be an option to treat and prevent gingivitis and reduce yeast counts in
children infected with HIV.
AN - rayyan-563560600
AU - MacHado, F. C.
AU - De Souza, I. P. R.
AU - Portela, M. B.
AU - De Araújo Soares, R. M.
AU - Freitas-Fernandes, L. B.
AU - Castro, G. F.
IS - 2
KW - chlorhexidine
toothpaste
adolescent
article
bacterial count
biofilm
Candida
Candida albicans
Candida tropicalis
child
classification
cohort analysis
drug effect
female
follow up
gel
gingivitis
highly active antiretroviral therapy
human
male
microbiology
periodontics
pilot study
saliva
tooth brushing
treatment outcome
LA - English
PY - 2011
SN - 0164-1263
SP - 153-157
ST - Use of chlorhexidine gel (0.2%) to control gingivitis and Candida species
colonization in human immunodeficiency virus-infected children: A pilot study
T2 - Pediatr. Dent.
TI - Use of chlorhexidine gel (0.2%) to control gingivitis and Candida species
colonization in human immunodeficiency virus-infected children: A pilot study
VL - 33
ID - 13974
ER -
TY - JOUR
AB - Background: Guided tissue regeneration (GTR) using membrane barriers is still
the reconstructive treatmeant of choice for a variety of periodontal defects.
Smokers, however, present a reduced regenerative response to GTR. The purpose of
the present study was to design and examine a new protocol with emphasis on anti-
infective therapy for patients who are cigarette smokers and who require GTR
procedures for the treatment of Class II furcation defects. Methods: Chronic
periodontitis patients who were smokers and who exhibited mandibular Class II
furcations were initially pooled for further assessment. Patients were randomly
assigned to either the experimental group (EG) or a control group (CG). Clinical
measurements and indices were recorded at baseline and at 6, 9, and 12 months, and
included: plaque assessment index; gingival assessment index; probing depth; and
probing attachment level (vertical [PAL-V] and horizontal [PAL-H]) using a
prefabricated acrylic stent as a reproducible reference point. All patients
underwent hygienic phase periodontal therapy. Next, GTR was performed, and the
furcation dimensions (height, width, and depth) were measured. A membrane was
placed, and a 25% metronidazole gel was then applied over the outer surface of the
membrane (EG only) and the flaps repositioned so that the membrane was completely
submerged. Instructions included twice daily rinses with chlorhexidine gluconate
0.2% for 1 week (CG) or as long as the membrane was in place (EG), doxycycline 100
mg × 1/day for 1 week (CG) or 6 to 8 weeks (EG), and ibuprofen 3 × 400 mg/day for 7
days. Patients were initially seen for prophylaxis weekly (EG) or biweekly (CG).
Metronidazole was applied to the free gingival margins and/or over the exposed
membrane at every prophylactic visit (EG). Six to 8 weeks after surgery, the
membrane was removed surgically, and the amount of new tissue growth (NTG) from the
cemento-enamel junction (CEJ) to the most coronal extension of the new tissue was
recorded. Following membrane retrieval, patients were seen for prophylaxis and oral
hygiene reinforcement every month (EG) or quarterly (CG). At 12 months
postoperatively, the area was surgically reentered and the surgical measurements
repeated. Results: Thirty-eight subjects, 21 females and 17 males, aged 35 to 61
were accepted in this study. Baseline clinical parameters were similar for both
groups. One year postoperatively, there was no statistically significant difference
in probing depth reduction or in horizontal PAL between EG and CG, but vertical PAL
gain was significantly greater in EG. As for alveolar parameters 1 year
postoperatively, the mid CEJ-crest distance and furcation width decreased in EG but
increased in CG. A similar trend was observed for furcation height. Furcation depth
reduction in both groups was similar. A comparison between new tissue growth at
retrieval and eventual bone formation 1 year postoperatively demonstrated a smaller
change in EG patients compared to CG patients, which was statistically significant
for both the distal and the mid-tooth area, as well as for the tooth mean.
Conclusions: While smoking prevented tissue maturation and mineralization, the
anti-infective protocol enhanced these processes, resulting in a more favorable
outcome. It is therefore suggested that when GTR is performed for Class II
furcation defects in smokers, anti-infective therapy should be incorporated into
the treatment protocol to enhance the regenerative outcome in these patients.
AN - rayyan-563560884
AU - Machtei, E. E.
AU - Oettinger-Barak, O.
AU - Peled, M.
DO - 10.1902/jop.2003.74.5.579
IS - 5
doxycycline
ibuprofen
metronidazole
adult
alveolar bone
antibiotic therapy
article
cigarette smoking
clinical article
clinical protocol
clinical trial
controlled study
drug efficacy
female
gingiva
human
male
mineralization
mouth hygiene
ossification
periodontal disease
periodontic device
periodontitis
stent
tissue flap
tissue growth
tissue regeneration
tooth plaque
treatment outcome
elyzol
Gore-Tex
LA - English
PY - 2003
SN - 0022-3492
SP - 579-584
ST - Guided tissue regeneration in smokers: Effect of aggressive anti-infective
therapy in Class II furcation defects
TI - Guided tissue regeneration in smokers: Effect of aggressive anti-infective
therapy in Class II furcation defects
VL - 74
ID - 14258
ER -
TY - JOUR
AB - Thyme extracts have the ability to inhibit both gram negative and positive
facultative bac-terial growth and inhibits plaque on the surfaces of the teeth.
Therefore, the aim of this study to evaluate the antibacterial properties of thyme
ethanolic extract towards P. gingivalis isolated clinically from periodontal
pocket. The antibacterial susceptibility, minimum inhibition concentration (MIC),
and minimum bactericidal concentration (MBC) of ethanolic thyme extract against P.
gingivalis were conducted by utilizing agar diffusion and 2-fold serial macro
dilution methods. Phytochemical analysis was carried out using gas chromatography–
mass spectrometry (GC-MS). P. gingivalis verification was done by using PCR test.
P. gingivalis was sensitive to all concentrations of thyme extract. MIC was 0.78
mg/mL, and MBC was 1.56 mg/mL against P. gingivalis. This could point to a
potentially effective substitute al-ternative to conventional drugs which used as
an adjuvant in the treatment of periodontitis.
AN - rayyan-563559719
AU - Madhloom, F.
AU - Hamozi, S. M.
AU - Alghanim, K. M.
AU - Zwain, M.
KW - 7820A
mass fragmentograph
spectrophotometer
Thymus vulgaris extract
agar diffusion
article
bacterial growth
bacterium isolation
broth dilution
clinical article
controlled study
dilution
DNA extraction
herbal medicine
human
in vitro study
mouth hygiene
nonhuman
periodontal pocket
periodontitis
phytochemistry
plaque index
substitution reaction
zone of inhibition
LA - English
PY - 2023
SN - 0326-2383
SP - 135-139
ST - In Vitro Antibacterial Activity of Ethanolic Thyme Extract against
Porphyromonas gingivalis Isolated from Periodontal Pocket
T2 - Lat. Am. J. Pharm.
TI - In Vitro Antibacterial Activity of Ethanolic Thyme Extract against
Porphyromonas gingivalis Isolated from Periodontal Pocket
VL - 42
ID - 13093
ER -
TY - JOUR
AB - RESULTS: Group I showed significant reduction in probing depth and attachment
gain compared with group II and III at one and three months period. The
inflammatory mediators levels were significantly reduced in all treatment groups at
one-month period. Except for group I, the reduced values were observed at three-
month period. CONCLUSION: The results suggest that treatment with nDOX gel as an
adjunct to SRP had anti-inflammatory effect by improving both clinical parameters
and inflammatory markers up to three months period. BACKGROUND AND OBJECTIVE: To
date, various drugs as host modulating agents had been suggested as adjunctive
treatment modality in the therapy of chronic periodontal disease. In this study,
the anti-inflammatory effect of subgingivally delivered nanostructured doxycycline
gel (nDOX) was evaluated and compared to conventional doxycycline gel (DOX) used as
adjunct to scaling and root planning (SRP) in the treatment of moderate chronic
periodontitis to reduce probing pocket depth. MATERIAL AND METHODS: Nanostructured
doxycycline gel (nDOX) was prepared using spray-drying technique with chitosan (CH)
as a matrix polymer, followed by dispersion in polyvinyl alcohol (PVA). The deepest
periodontal pocket in 45 patients suffering from moderate chronic periodontitis was
selected. The patients were divided into three groups following scaling and root
planning (SRP); group I: SRP + nDOX, group II: SRP + DOX and group III: SRP +
placeboCH. Plaque Index (PI), Gingival Index (GI), pocket depth (PD) and clinical
attachment level(CAL), as well as ginigival crevicular fluid levels of (GCF) IL-6
and TNF-α were assessed at baseline, 1 and 3 months following local drug
application.
AN - rayyan-563560276
AU - Madi, M.
AU - Pavlic, V.
AU - Samy, W.
AU - Alagl, A.
DO - 10.1080/00016357.2017.1385096
IS - 1
doxycycline
adult
drug effect
female
gel
gingivitis
human
male
middle aged
periodontal pocket
periodontitis
plaque index
LA - English
PY - 2018
SN - 1502-3850
SP - 71-76
ST - The anti-inflammatory effect of locally delivered nano-doxycycline gel in
therapy of chronic periodontitis
TI - The anti-inflammatory effect of locally delivered nano-doxycycline gel in
therapy of chronic periodontitis
VL - 76
ID - 13650
ER -
TY - JOUR
AB - The aim of this pilot study was to evaluate the effects of different use of
amine and stannous fluoride (AmF/SnF2)- containing toothpaste with and without a
mouthrinse (MeridolÂ®) on plaque accumulation and gingival health after four weeks'
use in patients wearing fixed orthodontic appliances. Plaque accumulation and
periodontal variables were recorded in 40 volunteers (mean age: 20.1Â±5.6 years),
who were randomly divided into two groups. They refrained from oral hygiene two
days before each assessment. The test group brushed with AmF/SnF2 toothpaste twice
daily for three minutes and rinsed with an AmF/SnF2 mouthrinse for 30 seconds. The
control group used only the AmF/SnF2 toothpaste twice daily, toothbrushing for
three minutes. Baseline values for plaque index (PI) and gingival index (GI) were
2.21Â±0.52 and 1.98Â±0.58 (meanÂ±SD) in the test group, 2.29Â±0.42 and 2.02Â±0.44
in the control group. After four weeks, PI and GI were 1.32Â±0.42 and 0.93Â±0.59 in
the test group, and 1.27Â±0.52 and 1.09Â±0.51 in the control group, respectively.
Bleeding on probing at baseline was 40% in the test group and 37.5% for the
controls; at the final evaluation, these values were 10.1% and 12.7%, respectively.
All of the indices were reduced significantly in both groups. There was no
statistically significant difference between the groups (P<0.05). Based on the
findings of this pilot study, it is suggested that the use of AmF/SnF2-containing
products resulted in beneficial clinical effects on plaque accumulation and
gingival health after placement of fixed orthodontic appliances. These beneficial
effects may be more pronounced after long-term and combined use of these products.
A six-month duration study with a larger sample of participants is needed to
confirm the promising results from this pilot.
AN - rayyan-563560545
AU - Madlena, M.
AU - Banoczy, J.
AU - Gotz, G.
AU - Marton, S.
AU - Kaan Jr, M.
AU - Nagy, G.
IS - 2
KW - amine
amine fluoride gel
amine fluoride solution
fluoride varnish
meridol
mouthwash
tin fluoride
toothpaste
adolescent
adult
article
chemistry
clinical trial
controlled study
drug combination
female
gingivitis
human
male
nonparametric test
orthodontic device
periodontics
pilot study
tooth plaque
LA - English
PY - 2012
SN - 2247-2452
SP - 57-61
ST - Effects of amine and stannous fluorides on plaque accumulation and gingival
health in orthodontic patients treated with fixed appliances: a pilot study
T2 - Oral Health Dent Manag
TI - Effects of amine and stannous fluorides on plaque accumulation and gingival
health in orthodontic patients treated with fixed appliances: a pilot study
VL - 11
ID - 13919
ER -
TY - JOUR
AB - Local delivery of antimicrobials has been investigated as a possible method
for controlling and treating periodontal disease. A number of antimicrobial agents
have been studied both as adjunctive therapies with scaling and root planing and as
stand-alone chemotherapies. More recent investigations have focussed on the
delivery of antimicrobials in sustained-release formulations designed to maintain
effective concentrations of drug within the periodontal pocket. This article
provides an overview of the development of the use of locally-delivered
metronidazole in periodontal therapy and the current state-of-the-art of the
technique. It is concluded that treatment with local delivery of metronidazole
seems to be as effective as scaling and root planing in untreated as well as in
recall subjects. However, there are reasons to suggest that local delivery of
metronidazole should not be used as a substitute for conventional treatment of
periodontal disease, since side-effects of long-term use and repeated use are not
known. The antibiotic regimen should preferably be used as an adjunct to surgical
and non-surgical therapy.
AN - rayyan-563562234
AU - Magnusson, I.
DO - 10.1111/j.1600-051X.1998.tb02398.x
IS - 11
PY - 1998
SN - ["0303-6979", "1600-051X"]
SP - 959-963
ST - The use of locally-delivered metronidazole in the treatment of periodontitis.
Clinical results
TI - The use of locally-delivered metronidazole in the treatment of periodontitis.
Clinical results
VL - 25
Y2 - 11
ID - 15608
ER -
TY - CONF
AN - rayyan-563562101
AU - Mahadlek, J.
AU - Charoenteeraboon, J.
AU - Choopun, S.
AU - Phaechamud, T.
DA - 2010
DO - 10.4028/www.scientific.net/AMR.93-94.479
SP - 479-484
ST - Role of zinc oxide on rheology of thermosensitive gel developed for
T2 - Advanced Materials Research
TI - Role of zinc oxide on rheology of thermosensitive gel developed for
75649141632&doi=10.4028%2fwww.scientific.net%2fAMR.93-
94.479&partnerID=40&md5=0fb2efe62dc5e1b4e1fe1e23dcb60f30
VL - 93
ID - 15475
ER -
TY - CPAPER
AB - Periodontal disease is a major cause of tooth loss, therefore a more recent
approach such as thermosensitive gel is loaded with antimicrobial drugs to be
delivered locally to the periodontal pocket. The effect of ZnO on thermosensitive
gel properties including gelation-gel melting temperature, rheology,
syringeability, and the release behavior of antimicrobial drug such as doxycycline
hyclate were investigated. The increased amount of ZnO apparently decreased the
gelation temperature of the Lutrol (R) F127 system. Syringeability of the
doxycycline hyclate-Lutrol (R) F127 systems were increased with the increased
amount of ZnO. System comprising zinc oxide could prolong the release of
doxycycline hyclate from Lutrol (R) F127 systems and could be delivered from a
syringe through a needle for utilizing in periodontitis therapy at the periodontal
pocket.
AN - rayyan-563562024
AU - Mahadlek, J.
AU - Choopun, S.
AU - Phaechamud, T.
DO - 10.4028/www.scientific.net/AMR.93-94.479
PY - 2010
SP - 479-+
T2 - FUNCTIONALIZED AND SENSING MATERIALS
TI - Role of Zinc Oxide on Rheology of Thermosensitive Gel Developed for
VL - 93
ID - 15398
ER -
TY - CONF
AN - rayyan-563561878
AU - Mahadlek, J.
AU - Phaechamud, T.
DA - 2013
DO - 10.4028/www.scientific.net/KEM.545.63
SP - 63-68
ST - Benzoyl peroxide In Situ forming antimicrobial gel for periodontitis
treatment
TI - Benzoyl peroxide In Situ forming antimicrobial gel for periodontitis
treatment
84876224211&doi=10.4028%2fwww.scientific.net
%2fKEM.545.63&partnerID=40&md5=62ec80d590bb1fa120cba25ee8e49234
VL - 545
ID - 15252
ER -
TY - CPAPER
AB - Periodontitis is an inflammatory disease of the supporting structures of the
tooth caused by bacterial infection which can result in tooth loss. The local
intra-pocket drug delivery system was interesting and highly effective for
periodontitis treatment. In situ forming gel system is the polymeric solution which
could transform into gel for localizing and sustaining the drug release at desired
site. This system has been recommended as one of suitable delivery system for this
purpose. Benzoyl peroxide (BPO) in situ forming gels were developed using Eudragit
RS as polymer dispersed in N-methyl-pyrrolidone (NMP). Peppermint oil and
polyethylene glycol 1500 were also incorporated as the excipients. The prepared
systems were evaluated for rheology, syringeability (using texture analyzers), in
situ gel formation (after injection into PBS pH 6.8), antimicrobial activity
(against Streptococcus mutans with agar diffusion) and drug release (with dialysis
method in PBS pH 6.8 at 50 rpm, 37 degrees C). The viscosity and syringeability of
the prepared systems was increased as the amount of BPO, peppermint oil or PEG 1500
was increased. All prepared gels showed the Newtonian flow which the viscosity was
decreased as the temperature was increased. All prepared gels comprising peppermint
oil and PEG 1500 could form in situ gel in used medium which the pH was close to
the environment pH of periodontal pocket. The inhibition zone against Streptococcus
mutans of the prepared system was significantly decreased when the peppermint oil
and PEG 1500 was incorporated owing to the higher viscous environment and
thereafter retardation of drug diffusion was evident. This effect could prolong the
drug release. From drug release test, all prepared gels could sustain the BPO
release for at least 96 hrs. Release kinetic obtained from curve fitting with
various release equations using least square fit technique indicated that the
release patterns were as Higuchi's model therefore the release of BPO was performed
with diffusion control. This developed BPO in situ forming gel presented its
ability as the controlled drug delivery system for localized antimicrobial activity
at periodontal pocket.
AN - rayyan-563562017
AU - Mahadlek, J.
AU - Phaechamud, T.
PY - 2013
SP - 63-68
T2 - MATERIALS SCIENCE AND TECHNOLOGY VII
TI - Benzoyl Peroxide In Situ Forming Antimicrobial Gel for Periodontitis
Treatment
VL - 545
ID - 15391
ER -
TY - CONF
AN - rayyan-563561907
AU - Mahadlek, J.
AU - Phaechamud, T.
DA - 2015
SP - 13-18
ST - Metrodidazole in situ forming Eudragit RS gel comprising different solvents
TI - Metrodidazole in situ forming Eudragit RS gel comprising different solvents
%2fKEM.659.13&partnerID=40&md5=e2be6fa8fa164161f6533c0c98ea4322
VL - 659
ID - 15281
ER -
TY - CONF
AN - rayyan-563561718
AU - Mahadlek, J.
AU - Senarat, S.
AU - Phaechamud, T.
DA - 2021
DO - 10.1016/j.matpr.2021.10.248
SP - 2394-2399
ST - In situ solvent removal-based Eudragit®L/dimethyl sulfoxide forming gel for
periodontal pocket drug delivery
T2 - Materials Today: Proceedings
TI - In situ solvent removal-based Eudragit®L/dimethyl sulfoxide forming gel for
periodontal pocket drug delivery
85126991369&doi=10.1016%2fj.matpr.2021.10.248&partnerID=40&md5=ecfcd3e38b065e17453c
0de2a59106cc
VL - 52
ID - 15092
ER -
TY - CPAPER
AB - Periodontitis is a chronic inflammatory disease of gum resulting from
Porphyromonas gingivalis infectious at periodontal pockets. In situ forming gel
(ISG) effectively delivers the antimicrobial agents to this targeted site. This
study was to develop the dimethyl sulfoxide (DMSO) removal-based ISGs of Eudragit
(R) L and their physicochemical properties were evaluated including the viscosity,
rheological behavior, in vitro matrix formation, in vitro doxycycline hyclate (DH)
release and antimicrobial activities. The ISGs showed the Newtonian flow which an
increase in Eudragit (R) L amount enhanced a viscosity. They transformed into an
opaque gel after exposure a simulated crevicular fluid and modulated the DH release
longer than 3 days. The percentage of drug release from DMSO removal-based ISG
containing 10, 15, 20 and 25% w/w of Eudragit (R) L was 95.9, 90.5, 79.8 and 70.0,
respectively. Thus, DH release depended on the amount of Eudragit (R) L loading and
corresponded with the polymeric matrix formation. The high Eudragit (R) L loading
formulation retarded notably on the solvent removal owing to a thicker gel barrier.
The DH-loaded in situ solvent removal-based Eudragit (R) L/ DMSO forming gels
presented the efficient antimicrobial activities against Staphylococcus aureus,
Escherichia coli, Candida albicans and Porphyromonas gingivalis. Therefore,
Eudragit (R) L/DMSO ISG exhibited as a potential periodontal pocket drug delivery
system based on solvent removal mechanism. Copyright (c) 2021 Elsevier Ltd. All
rights reserved.
AN - rayyan-563562180
AU - Mahadlek, J.
AU - Senarat, S.
AU - Phaechamud, T.
DO - 10.1016/j.matpr.2021.10.248
PY - 2022
SP - 2394-2399
TI - In situ solvent removal-based Eudragit (R) L/dimethyl sulfoxide forming gel
for periodontal pocket drug delivery
VL - 52
ID - 15554
ER -
TY - JOUR
AB - The capabilities of principal component regression (PCR) and multiple linear
regression (MLR) were evaluated to decipher and predict the impact of formulation
and process parameters on the modeled metronidazole benzoate (MB)–ethyl cellulose
(EC) microsponge (MBECM) properties. MBECM were prepared by a quasi-emulsion
solvent diffusion method. A minimum experimentation was designed using Box-Behnken
approach with one center point after initial screening experiments. Data was
modeled by principal component analysis (PCA), PCR, and MLR. Two distinct groupings
of developed MBECM was observed in initial qualitative PCA as a function of their
respective formulation and processing parameters. Group A formulations with low
dichloromethane, high PVA, and low stirring speed exhibited larger particle size,
lower entrapment efficiency (EE), and lower actual drug content (ADC) than Group B
formulations. Optimized quantitative PCR and MLR models demonstrated a linear
dependence of particle size and quadratic dependence of EE and ADC on the studied
formulation and process parameters. Interestingly, MLR models showed relatively
better predictability of the selected MBECM formulation properties when compared
with PCR. MBECM were amorphous in nature and spherical shaped. Carbopol® 940 NF
based hydrogel of selected MBECM formulation exhibited a prolonged MB release than
the commercial MB gel (Metrogyl®), showing no signs of necrosis in the goat mucosa.
Thus, a properly designed minimum experimentation coupled with multivariate
modeling generated a knowledge-rich target space, which enabled to understand and
predict the performance of developed MBECM within a prescribed design space.
AN - rayyan-563560184
AU - Mahaparale, P. R.
AU - Vinjamuri, B. P.
AU - Chavan, M. S.
AU - Chougule, M. B.
AU - Haware, R. V.
DO - 10.1208/s12249-019-1383-2
IS - 5
KW - carbomer
dichloromethane
ethyl cellulose
metronidazole
polyvinyl alcohol
actual drug content
animal tissue
article
controlled study
drug formulation
emulsion
encapsulation
entrapment efficiency
histopathology
hydrogel
mathematical model
multiple linear regression analysis
nonhuman
particle size
periodontitis
physical chemistry
priority journal
metrogyl
LA - English
PY - 2019
SN - 1530-9932
ST - Computational Predictability of Microsponge Properties Using Different
Multivariate Models
TI - Computational Predictability of Microsponge Properties Using Different
Multivariate Models
VL - 20
ID - 13558
ER -
TY - JOUR
AB - Introduction and Aim: Ginko biloba is a leaf extract, which has shown to
possess potential anti-bacterial and antiviral property thereby reducing the
bacterial and viral load in the oral environment. However very limited studies have
shown its impact on oral diseases. Hence, we aimed to identify the therapeutic
properties of Ginko biloba on the prevalence of HSV, EBV, CMV and Porphyromonas
gingivalis (Pg) in the sub-gingival plaque of generalized chronic periodontitis
subjects before and after the application of 3% Gingko biloba gel (Gb Gel) as a
local drug delivery. Materials and Methods: Twenty-six subjects, with generalized
chronic periodontitis were selected and divided based on a split mouth design. The
test sites were treated with scaling and root planning (SRP) and application of 3%
Gb Gel, while the placebo sites were treated with SRP and placebo gel. Clinical
parameters were recorded and the presence of HSV, EBV, CMV along with Pg were
assessed at baseline and 3 months. Results: The clinical parameters such as probing
pocket depth (PPD), clinical attachment level (CAL), bleeding index (BI), plaque
index (PI) and levels of HSV, EBV, CMV along with Pg was significantly reduced in
Gingko biloba sites as compared to placebo sites. Conclusion: With improvement in
periodontal status, in near future, Gb Gel can be used as a local drug delivery
agent to provide a new therapeutic alternative.
AN - rayyan-563560114
AU - Mahendra, J.
AU - Kumari, B. N.
AU - Mahendra, L.
AU - Yagnik, K.
DO - 10.51248/.v40i3.20
IS - 3
KW - gel
Ginkgo biloba extract
adult
aged
alveolar bone loss
Alzheimer disease
animal experiment
animal model
antibiotic therapy
antiviral activity
article
asthma
bleeding
clinical article
controlled study
Cytomegalovirus
dementia
dental scaling
depression
drug efficacy
drug formulation
drug screening
drug synthesis
Epstein Barr virus
female
Ginkgo biloba
Herpes simplex virus
human
intervention study
male
nonhuman
plaque index
prevalence
rat
root planing
LA - English
PY - 2020
SN - 0970-2067
SP - 324-330
ST - Antimicrobial efficacy of 3% gingko biloba gel as a local drug delivery agent
in the treatment of chronic periodontitis: A cross sectional comparative clinical
study
T2 - Biomedicine
TI - Antimicrobial efficacy of 3% gingko biloba gel as a local drug delivery agent
in the treatment of chronic periodontitis: A cross sectional comparative clinical
study
VL - 40
ID - 13488
ER -
TY - JOUR
AB - AIM: The aim of the present study was to assess the periodontal status of
individuals and the presence of red complex microorganisms (RCM), such as Treponema
denticola (Td), Porphyromonas gingivalis, and Tannerella forsythia in the
subgingival tissues of periodontitis patients before and after the application of
4% mangostana gel (Garcinia mangostana [MGA]) as an adjunct to scaling and root
planing (SRP). METHODS: Twenty-five patients (MGA group) were treated with SRP, and
the subgingival application of mangostana gel was used as local drug delivery.
Twenty-five patients (placebo group) were treated with SRP and placebo gel.
Clinical parameters were recorded, and the presence of RCM was assessed at baseline
and at the third month. RESULTS: Clinical parameters, such as probing pocket depth,
clinical attachment level, bleeding index, plaque index, and Td, were significantly
reduced in the MGA group compared to the placebo group from baseline to the third
month. CONCLUSION: There was a significant improvement in the periodontal status
with a reduction in Td with the application of mangostana gel in periodontal
pockets. In the near future, 4% mangostana gel can be used as an adjunct to SRP to
provide a new dimension to periodontal therapy.
AN - rayyan-563560285
AU - Mahendra, J.
AU - Mahendra, L.
AU - Svedha, P.
AU - Cherukuri, S.
AU - Romanos, G. E.
DO - 10.1111/jicd.12262
IS - 4
KW - plant extract
adult
aged
controlled study
female
Garcinia mangostana
gel
human
male
microbiology
middle aged
phytotherapy
treatment outcome
LA - English
PY - 2017
SN - 2041-1626
ST - Clinical and microbiological efficacy of 4% Garcinia mangostana L. pericarp
gel as local drug delivery in the treatment of chronic periodontitis: A randomized,
TI - Clinical and microbiological efficacy of 4% Garcinia mangostana L. pericarp
gel as local drug delivery in the treatment of chronic periodontitis: A randomized,
VL - 8
ID - 13659
ER -
TY - JOUR
AB - The purpose of this research was to reduce the polymer concentration and to
obtain reasonable viscosity at a lower concentration of pluronic by the addition of
a viscosity modifier. A 20% wt/wt pluronic gel was prepared on a weight basis using
the cold method. The effect of the amount of tetracycline and Aerosil on gel
properties was studied. The gel was evaluated using different parameters:
polarizing microscopy, gelation, gel melting, bioadhesivity, viscosity, drug
release, and stability of enzyme. An in vivo study was performed to evaluate the
clinical efficiency of the liquid crystalline gel. Addition of Aerosil to the gel
favored hexagonal phase formation. Viscosity and bioadhesivity increased with an
increase in the concentration of Aerosil. Release of tetracycline was sustained as
the concentration of Aerosil increased. Various clinical parameters confirmed the
acceptability and efficiency of this gel system.
AN - rayyan-563560760
AU - Maheshwari, M.
AU - Miglani, G.
AU - Mali, A.
AU - Paradkar, A.
AU - Yamamura, S.
AU - Kadam, S.
DO - 10.1208/pt070356
IS - 3
KW - aerosil
poloxamer
polymer
proteinase
serratiopeptidase
tetracycline
adhesion
adult
article
Bacillus licheniformis
Bacillus subtilis
bacterial count
clinical article
Coccidia
controlled study
drug formulation
drug release
drug research
enzyme stability
female
gel
gelation
human
in vivo study
male
melting point
periodontitis
polarization microscopy
spirochete
treatment outcome
viscosity
LA - English
PY - 2006
SN - ["1530-9932", "1530-9932"]
SP - E1-E10
ST - Development of tetracycline-serratiopeptidase-containing periodontal gel:
Formulation and preliminary clinical study
TI - Development of tetracycline-serratiopeptidase-containing periodontal gel:
Formulation and preliminary clinical study
VL - 7
ID - 14134
ER -
TY - JOUR
AB - OBJECTIVES: To compare the effectiveness of metronidazole gel and mobile
telephone short-message service (SMS) reminders on gingivitis in patients
undergoing fixed orthodontic treatment. MATERIALS AND METHODS: The trial was double
blinded (patient and investigator), and only the clinical trial unit pharmacist was
unblinded. Data were collected from patients undergoing fixed orthodontic treatment
for at least 6 months. A total of 66 patients were randomly assigned to either 0.8%
metronidazole gel (n = 22), SMS reminder and placebo gel (n = 22), or placebo
(control) group only (n = 22). Gingival index (GI), bleeding index (BI), and
orthodontic plaque index (OPI) were evaluated on several teeth at baseline (T0) and
after 4 weeks (T1). Paired-sample t-tests were used to compare mean differences of
indexes at T0 and T1 in the groups, and independent-sample t-tests were used to
determine the effects of interventions compared with the controls. RESULTS: Data
from 64 patients were analyzed; there were 2 dropouts. There were statistically
significant (P < .05) reductions in GI, BI, and OPI scores from T0 to T1 for each
intervention. However, there were no significant differences between each
intervention and the control group. There were no adverse effects. CONCLUSIONS: The
null hypothesis could not be rejected. There is no difference between interventions
(application of 0.8% metronidazole gel and SMS reminder for reinforcing oral
hygiene) in reducing gingival inflammation in orthodontic patients.
AN - rayyan-563560021
AU - Mahmood, H. T.
AU - Fatima, F.
AU - Fida, M.
AU - Sukhia, R. H.
AU - Irfan, S.
AU - Malik, D.
AU - Younus, A.
AU - Afzal, E.
DO - 10.2319/052920-490.1
IS - 2
KW - metronidazole
controlled study
gingivitis
human
mouth hygiene
periodontal index
plaque index
LA - English
PY - 2021
SN - 1945-7103
SP - 220-226
ST - Effectiveness of metronidazole gel and mobile telephone short-message service
reminders on gingivitis in orthodontic patients
T2 - Angle Orthod
TI - Effectiveness of metronidazole gel and mobile telephone short-message service
reminders on gingivitis in orthodontic patients
VL - 91
ID - 13395
ER -
TY - JOUR
AB - Objective: To compare at-home systems with reduced daily time of use (10%
hydrogen peroxide [HP] gel with prefilled (PT) or customized trays (CT), and 10%
carbamide peroxide [CP] gel), with the conventional nightguard vital bleaching (10%
CP). Bleaching efficacy, adverse effects, and patient's satisfaction were
evaluated. Methods: Sixty participants were randomly divided into treatments (14
days): Opalescence GO (OGO)-10%HP PT-30 min, White Class-10%HP CT-30 min,
Opalescence PF-10%CP CT-2 h, and Opalescence PF-10%CP CT-8 h. Color difference
(visual and spectrophotometer), tooth sensitivity (visual analogue scale), gingival
condition (Löe index), enamel mineralization (laser fluorescence), and patients'
satisfaction (questionnaire) were assessed. Statistical tests were applied (5%).
Results: After 1 year, color difference was similar for the groups (p > 0.05). All
groups showed similar sensitivity risk (p > 0.05). The intensity of sensitivity and
gingival irritation was mild for all gels, but higher for OGO. Fluorescence after
bleaching remained similar to those of sound enamel. All participants were
satisfied with treatments. Conclusions: All systems produced similar bleaching
efficacy, which was maintained after 1 year. Patients were satisfied with bleaching
outcomes. Tooth sensitivity occurred in all groups, but with overall mild
intensity. No relevant gingival irritation and enamel demineralization was
observed. Clinical significance: Bleaching with 10% HP gels in prefilled and CTs
represent efficacious alternative for tooth color change, with patients' acceptance
similar to conventional 10% CP. Patients must be warned about the mild sensitivity
and gingival irritation potential, mainly with PTs.
AN - rayyan-563559931
AU - Mailart, M. C.
AU - Sakassegawa, P. A.
AU - Santos, K. C.
AU - Torres, C. R. G.
AU - Palo, R. M.
AU - Borges, A. B.
DO - 10.1111/jerd.12814
IS - 8
KW - AAE:55616416.0.0000.0077
diode laser
laser fluorescence device
Oral-B
spectrophotometer
toothbrush
Vita Easyshade
carbamide peroxide
hydrogen peroxide
adult
article
biomechanics
bleaching
burning sensation
calibration
canine tooth
controlled study
demineralization
enamel
female
first molar
fluorosis
follow up
gastrointestinal disease
gingiva bleeding
gingiva disease
human
human experiment
hyperalgesia
hypersensitivity
incisor
male
malocclusion
mineralization
mouth hygiene
normal human
outcome assessment
pain intensity
periodontal disease
prophylaxis
prospective study
questionnaire
tooth color
tooth malformation
visual analog scale
xerostomia
LA - English
PY - 2021
SN - ["1708-8240", "1496-4155"]
SP - 1175-1185
ST - One-year follow-up comparing at-home bleaching systems outcomes and the
impact on patient's satisfaction: Randomized clinical trial
T2 - J. Esthetic Restorative Dent.
TI - One-year follow-up comparing at-home bleaching systems outcomes and the
impact on patient's satisfaction: Randomized clinical trial
VL - 33
ID - 13305
ER -
TY - JOUR
AB - Herbal extracts have been successfully used in dentistry as tooth cleaning
and antimicrobial plaque agents. The aim of this study was to evaluate the clinical
effects of a dental gel containing barberry extracts (from Berberis vulgaris) on
gingivitis and microbial plaque control. A double blind clinical trial study was
conducted in a dormitory on 45 boys aged 11-12 years having the same socioeconomic
conditions. These students were divided into 3 groups; the first group (25
students) using barberry gel, and the second group (10 students) using placebo gel
without active ingredient. To compare the activity of our gel with an active
antiplaque, a third group of 10 students using Colgate® antiplaque toothpaste was
also considered. At the beginning all subjects were examined for plaque index (PI)
and gingival index (GI). These tests were re-evaluated after 21 days of using the
above mentioned dentifrices. The results showed that barberry gel has reduced the
PI for about 56%. This reduction was 18.5% for placebo and 44% for Colgate®
antiplaque groups. Considering means of PI (?PI) and GI (?GI) of different groups,
there was significant difference between barberry and placebo gel's groups and
between placebo and Colgate® groups, but the difference between barberry and
Colgate® groups was not significant. This study indicates that the barberry dental
gel effectively controls microbial plaque and gingivitis in the school aged
children; therefore, the use of barberry dental gel is strongly recommended. © 2007
Tehran University of Medical Sciences. All rights reserved.
AN - rayyan-563560739
AU - Makarem, A.
AU - Khalili, N.
AU - Asodeh, R.
IS - 2
KW - berberis vulgaris extract
colgate
placebo
plant extract
toothpaste
unclassified drug
aqueous solution
article
Berberis
Berberis vulgaris
clinical article
clinical trial
controlled study
disease control
drug effect
drug efficacy
gel
gingivitis
human
male
school child
social status
student
tooth plaque
LA - English
PY - 2007
SN - ["0044-6025", "0044-6025"]
SP - 91-94
ST - Efficacy of barberry aqueous extracts dental gel on control of plaque and
gingivitis
T2 - Acta Med. Iran.
TI - Efficacy of barberry aqueous extracts dental gel on control of plaque and
gingivitis
VL - 45
ID - 14113
ER -
TY - JOUR
AN - rayyan-563561185
AU - Makuch, A.
AU - Klimm, W.
IS - 3
KW - chlorhexidine
placebo
toothpaste
adult
article
bacterium
clinical trial
drug effect
gingivitis
human
tooth plaque
LA - German
PY - 1984
SN - 0302-4725
SP - 138-145
ST - Microbiological and clinical studies on an oral hygiene cleanser-containing
gel Dentosmin P
T2 - Mikrobiologische und klinische Untersuchungen über das putzkörperhaltige
Mundhygienegel Dentosmin P.
TI - Microbiological and clinical studies on an oral hygiene cleanser-containing
gel Dentosmin P
VL - 34
ID - 14559
ER -
TY - JOUR
AB - We recently presented evidence showing that cementum protein 1 (CEMP1)
promotes periodontal ligament (PDL) cell migration, proliferation, expression of
bone, and cementum-matrix proteins and mineralisation. In other words, it induces
PDL precursor cells commitment toward a cementoblast-like cells phenotype. The
intracellular signalling pathways involved in cementoblast differentiation and
mineralisation have not been well characterised. JNK and p38 protein kinases
(MAPKs) are intracellular signalling pathways and key mediators of cellular
processes such as proliferation and differentiation. Since signalling pathways
involving MAPKs have been associated with osteoblastic phenotype, in this study we
investigated the effect of hrCEMP1 and mineralising media containing β-
glycerophosphate and ascorbic acid on the activation of p38-MAPK and JNK-MAPK in
cementoblast-like cells. Our results show that mineralising media and hrCEMP1
induced phosphorylation of p38 and JNK kinases. Mineralising media containing
hrCEMP1 increased the activation of p38-MAPK and its translocation to the cell
nucleus; increased phosphorylation of JNK-MAPK and induced the phosphorylation of
the protein C-JUN. We also demonstrate that hrCEMP1 regulates the expression of
BSP, OCN, and ALP specific activity. We found that hrCEMP1 and mineralising media
promote nodule formation. These findings give an insight into the signalling
pathways activated by hrCEMP1 and suggest likely components of the mechanisms that
regulate the formation and regeneration of cementum and surrounding connective
tissues. © 2013 The Authors.
AN - rayyan-563560439
AU - Maldonado, S.
AU - Romo, E.
AU - Serrano, J.
AU - Pérez, A.
AU - Guerra, C.
AU - Zeichner-David, M.
AU - Mercado, G.
AU - Arzate, H.
DO - 10.1002/cbi3.10011
IS - 1
ascorbic acid
bone morphogenetic protein
bone sialoprotein
cementum protein 1
osteocalcin
osteopontin
unclassified drug
article
cell proliferation
cell survival
cementoblast
tooth cementum
controlled study
human
human cell
priority journal
protein content
protein expression
tooth development
Western blotting
LA - English
PY - 2014
SN - 2041-5346
SP - 8-16
ST - Cementum protein 1 (CEMP1) activates p38 and JNK during the mineralisation
process by cementoblast-like cells in vitro
T2 - Cell Biol. Intern. Rep.
TI - Cementum protein 1 (CEMP1) activates p38 and JNK during the mineralisation
process by cementoblast-like cells in vitro
VL - 21
ID - 13813
ER -
TY - JOUR
AB - Developing new barrier membranes with improved biomechanical characteristics
has acquired much interest owing to their crucial role in the field of periodontal
tissue regeneration. In this regard, we enriched the electrospun polycaprolactone
(PCL)/gelatin (Gel) membranes by adding bioglass (BG) or Cu-doped bioglass (CuBG)
and examined their cellular adhesion and proliferation potential in the presence of
alveolar bone marrow-derived mesenchymal stem cells (aBMSCs). The membranes were
fabricated and characterized using mechanical strength, SEM, FTIR, EDX, and ICP
assay. Besides, aBMSCs were isolated, characterized, and seeded with a density of
35,000 cells in each experimental group. Next, the cellular morphology, cell
adhesion capacity, proliferation rate, and membrane antibacterial activity were
assessed. The results displayed a significant improvement in the wettability, pore
size, and Young's modulus of the PCL membrane following the incorporation of
gelatin and CuBG particles. Moreover, all scaffolds exhibited reasonable
biocompatibility and bioactivity in physiological conditions. Although the
PCL/Gel/CuBG membrane revealed the lowest primary cell attachment, cells were grown
properly and reached the confluent state after seven days. In conclusion, we found
a reasonable level of attachment and proliferation of aBMSCs on all modified
membranes. Meanwhile, a trace amount of Cu provided superiority for PCL/Gel/CuBG in
periodontal tissue regeneration.
AN - rayyan-563561102
AU - Malekahmadi, B.
AU - Esfahanian, V.
AU - Ejeian, F.
AU - Dastgurdi, M. E.
AU - Agheb, M.
AU - Kaveian, F.
AU - Rafienia, M.
AU - Nasr-Esfahani, M. H.
DO - 10.3390/biomimetics7010019
IS - 1
J2 - Biomimetics (Basel)
LA - eng
N1 - Isfahan (Khorasgan) Branch, Dental School, Islamic Azad University, Isfahan
8155139998, Iran.; Cell Science Research Center, Department of Animal
Biotechnology, Royan Institute for Biotechnology, ACECR, Isfahan 8159358686, Iran.;
Isfahan (Khorasgan) Branch, Department of Periodontics, Dental School, Islamic Azad
University, Isfahan 8155139998, Iran.; Cell Science Research Center, Department of
Animal Biotechnology, Royan Institute for Biotechnology, ACECR, Isfahan 8159358686,
Iran.; Private Practitioner (Endodontist), Toronto, ON L3T0C9, Canada.; Department
of Biomaterials, Tissue Engineering and Nanotechnology, School of Advanced
Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan
8174673461, Iran.; Biosensor Research Center, Isfahan University of Medical
Science, Isfahan 8174673461, Iran.; Biosensor Research Center, Isfahan University
of Medical Science, Isfahan 8174673461, Iran.; Cell Science Research Center,
Department of Animal Biotechnology, Royan Institute for Biotechnology, ACECR,
Isfahan 8159358686, Iran.
PY - 2022
ST - In Vitro Study of the Recruitment and Expansion of Mesenchymal Stem Cells at
the Interface of a Cu-Doped PCL-Bioglass Scaffold
T2 - Biomimetics (Basel, Switzerland)
TI - In Vitro Study of the Recruitment and Expansion of Mesenchymal Stem Cells at
the Interface of a Cu-Doped PCL-Bioglass Scaffold
VL - 7
Y2 - 1 y3 - 21
ID - 14476
ER -
TY - JOUR
AB - As a category of small peptides frequently found in nature, antimicrobial
peptides (AMPs) constitute a major part of the innate immune system of various
organisms. Antimicrobial peptides feature various inhibitory effects against fungi,
bacteria, viruses, and parasites. Due to the increasing concerns of antibiotic
resistance among microorganisms, development of antimicrobial peptides is an
emerging tool as a favorable applicability prospect in food, medicine, aquaculture,
animal husbandry, and agriculture. This review presents the latest research
progress made in the field of antimicrobial peptides, such as their mechanism of
action, classification, application status, design techniques, and a review on
decoration of nanoparticles and polymers with AMPs that are used in treating
multidrug resistance. Lastly, we will highlight recent progress in antiviral
peptides to treat emerging viral diseases (e.g., anti-coronavirus peptides) and
discuss the outlook of AMP applications.
AN - rayyan-563559877
AU - Salatin, S.
AU - Khezri, K.
AU - Lee, J. Y.
AU - Lotfipour, F.
DO - 10.3389/fmicb.2022.831655
KW - 00659971
beta defensin 2
beta defensin 3
carbon nanotube
defensin
dendrimer
hydrogel
indolicidin
lactoferrin
liposome
metal nanoparticle
nanofiber
nanoparticle
polymer
ropocamptide
antiviral activity
cancer therapy
micelle
multidrug resistance
nonhuman
review
LA - English
PY - 2022
SN - 1664-302X
ST - Targeting Multidrug Resistance With Antimicrobial Peptide-Decorated
Nanoparticles and Polymers
TI - Targeting Multidrug Resistance With Antimicrobial Peptide-Decorated
Nanoparticles and Polymers
VL - 13
ID - 13251
ER -
TY - JOUR
AN - rayyan-563561182
AU - Malić, M.
AU - Konjhodzić, H.
AU - Filipović, M.
IS - 3
KW - plant resin
propolis
adolescent
adult
article
comparative study
gingivitis
human
middle aged
periodontitis
LA - Serbian
PY - 1985
SN - 0350-5499
SP - 107-110
ST - Effect of Propolis-gel in the treatment of gingival inflammation
T2 - Efekti Propolis-gel-a u terapiji gingivalne inflamacije.
TI - Effect of Propolis-gel in the treatment of gingival inflammation
VL - 14
ID - 14556
ER -
TY - JOUR
AN - rayyan-563562450
AU - Malkhassian, G.
DO - 10.1016/j.joen.2010.01.020
IS - 4
PY - 2010
SN - ["0099-2399", "1878-3554"]
SP - 596-597
ST - Antibacterial Efficacy of MTAD Final Rinse and Two Percent Chlorhexidine Gel
Medication in Teeth with Apical Periodontitis Reply
TI - Antibacterial Efficacy of MTAD Final Rinse and Two Percent Chlorhexidine Gel
Medication in Teeth with Apical Periodontitis Reply
VL - 36
Y2 - 4
ID - 15824
ER -
TY - JOUR
AB - Introduction: Clinical assessment of the efficacy of novel root canal
disinfection protocols is an important focus in endodontic research. This
randomized double-blinded study assessed the antibacterial efficacy of a final
rinse with BioPure MTAD (MTAD) and intracanal medication with 2% chlorhexidine gel
(CHX) in teeth with apical periodontitis. Methods: Canals in 30 teeth (single-
rooted and multi-rooted) were prepared by using 1.3% NaOCl, rinsed with MTAD or
saline in random sequence, medicated with CHX for 7 days, irrigated with 1.3%
NaOCl, and filled. Bacteriologic root canal samples were obtained by aspiration
before (1A) and after (1B) canal preparation, after the final rinse (1C), after CHX
was flushed (2A), and after final irrigation (2B). Bacteria were enumerated by
epifluorescence-microscopy (EFM) by using 2 staining methods and by colony-forming-
unit (CFU) counts after 14 days of incubation. Results: Bacterial counts (EFM) in
1B were greater than 95% decreased from 1A. Low bacterial densities in 1B, 1C, 2A,
and 2B did not differ significantly from each other. EFM counts were consistently
higher than CFU counts. Conclusions: The final rinse with MTAD and medication with
CHX did not reduce bacterial counts beyond levels achieved by canal preparation
with NaOCl. © 2009 American Association of Endodontists.
AN - rayyan-563560661
AU - Manzur, A. J.
AU - Legner, M.
AU - Fillery, E. D.
AU - Manek, S.
AU - Basrani, B. R.
AU - Friedman, S.
DO - 10.1016/j.joen.2009.08.003
IS - 11
chlorhexidine
citric acid
doxycycline
glass ionomer
gutta percha
hypochlorite sodium
MTAD (intracanal irrigant)
Photac Fil
Photac-Fil
polysorbate
resin
adult
aerobic bacterium
aged
anaerobic bacterium
article
bacterial count
clinical trial
cohort analysis
comparative study
controlled study
dental surgery
endodontics
female
human
devices
male
methodology
microbiology
middle aged
tooth pulp
LA - English
PY - 2009
SN - 0099-2399
SP - 1483-1490
Medication in Teeth with Apical Periodontitis: A Randomized Double-blinded Clinical
Trial
T2 - J. Endod.
Medication in Teeth with Apical Periodontitis: A Randomized Double-blinded Clinical
Trial
VL - 35
ID - 14035
ER -
TY - COMP
AB - INTRODUCTION: Clinical assessment of the efficacy of novel root canal
disinfection protocols is an important focus in endodontic research. This
randomized double-blinded study assessed the antibacterial efficacy of a final
rinse with BioPure MTAD (MTAD) and intracanal medication with 2% chlorhexidine gel
(CHX) in teeth with apical periodontitis. METHODS: Canals in 30 teeth (single-
rooted and multi-rooted) were prepared by using 1.3% NaOCl, rinsed with MTAD or
saline in random sequence, medicated with CHX for 7 days, irrigated with 1.3%
NaOCl, and filled. Bacteriologic root canal samples were obtained by aspiration
before (1A) and after (1B) canal preparation, after the final rinse (1C), after CHX
was flushed (2A), and after final irrigation (2B). Bacteria were enumerated by
epifluorescence-microscopy (EFM) by using 2 staining methods and by colony-forming-
unit (CFU) counts after 14 days of incubation. RESULTS: Bacterial counts (EFM) in
1B were greater than 95% decreased from 1A. Low bacterial densities in 1B, 1C, 2A,
and 2B did not differ significantly from each other. EFM counts were consistently
higher than CFU counts. CONCLUSIONS: The final rinse with MTAD and medication with
CHX did not reduce bacterial counts beyond levels achieved by canal preparation
with NaOCl.
AN - rayyan-563561266
AU - Manzur, A. J.
AU - Legner, M.
AU - Fillery, E. D.
AU - Manek, S.
AU - Basrani, B. R.
AU - Friedman, S.
CY - United States
DO - 10.1016/j.joen.2009.08.003
ET - 11
J2 - J Endod
KW - Adult
Aged
Bacteria, Aerobic/isolation & purification
Bacteria, Anaerobic/isolation & purification
Citric Acid/*therapeutic use
Cohort Studies
Dental Restoration, Permanent/methods
Double-Blind Method
Doxycycline/*therapeutic use
Female
Glass Ionomer Cements
Gutta-Percha/therapeutic use
Humans
Male
Microscopy, Fluorescence
Middle Aged
Periapical Periodontitis/microbiology/*therapy
Polysorbates/*therapeutic use
Resins, Synthetic
Root Canal Filling Materials/therapeutic use
Root Canal Obturation
Root Canal Preparation/instrumentation/*methods
Sodium Hypochlorite/therapeutic use
LA - eng
N1 - Department of Endodontics, Faculty of Dentistry, University of Toronto,
Ontario, Canada. gevik.malkhassian@dentistry.utoronto.ca
PY - 2009
SP - 1483-90
ST - Antibacterial efficacy of MTAD final rinse and two percent chlorhexidine gel
medication in teeth with apical periodontitis: a randomized double-blinded clinical
trial
T2 - Journal of endodontics
TI - Antibacterial efficacy of MTAD final rinse and two percent chlorhexidine gel
medication in teeth with apical periodontitis: a randomized double-blinded clinical
trial
VL - 35
Y2 - 11
ID - 14640
ER -
TY - JOUR
AB - BACKGROUND: Over the years, various antimicrobials have been tried and tested
in the treatment of periodontitis. Chlorhexidine (CHX) has emerged as the gold
standard. In recent years, trend has shifted toward the use of agents with
antibacterial, anti-inflammatory, and osteoblastic activity. Boric acid (BA) is one
such agent which possess all such properties and thus been evaluated in the
treatment of periodontitis. AIM AND OBJECTIVE: The aim of the study is to compare
and evaluate the efficacy of 0.75% BA gel versus 1% CHX gel as an adjunct to
scaling and root planing in patients with chronic periodontitis both clinically and
microbiologically. MATERIALS AND METHODS: The present study was a randomized,
placebo-controlled clinical trial where 45 systemically healthy patients with
chronic periodontitis were included in the study. About 15 patients each were
divided into three groups, that is, Group I received BA gel, Group II received CHX
gel, and Group III received placebo gel as a local drug delivery agent. Clinical
parameters such as gingival index, plaque index, modified sulcus bleeding index,
probing pocket depth, and clinical attachment level were evaluated at baseline and
6-month follow-up. Microbiological analysis to check for mixed anaerobic flora was
done using subgingival plaque samples at baseline and 3 months after treatment.
RESULTS: Significant reduction was seen in all clinical parameters in both BA and
CHX gel groups as compared to control group (P < 0.05). However, on comparing BA
gel group with CHX gel, the results were statistically insignificant (P > 0.05).
CONCLUSION: BA gel and CHX gel both were equally effective in improving the
clinical and microbiologic parameters in patients with chronic periodontitis when
used as a local drug delivery agent.
AN - rayyan-563561103
AU - Mamajiwala, A.
AU - Sethi, K. S.
AU - Mahale, S. A.
AU - Raut, C. P.
AU - Karde, P. A.
AU - Kale, A. M.
DO - 10.4103/ccd.ccd_752_18
IS - 3
LA - eng
N1 - Department of Periodontology, MGV's KBH Dental College and Hospital, Nashik,
Maharashtra, India.; Department of Periodontology, MGV's KBH Dental College and
Hospital, Nashik, Maharashtra, India.; Department of Periodontology, MGV's KBH
Dental College and Hospital, Nashik, Maharashtra, India.; Department of
Periodontology, MGV's KBH Dental College and Hospital, Nashik, Maharashtra, India.;
Department of Periodontology, MGV's KBH Dental College and Hospital, Nashik,
Maharashtra, India.; Department of Periodontology, MGV's KBH Dental College and
Hospital, Nashik, Maharashtra, India.
PY - 2019
SN - 0976-237X (Print)
SP - 457-464
ST - Comparative Evaluation of Boric Acid Gel versus Chlorhexidine Gel in the
Treatment of Chronic Periodontitis: Randomized, Placebo-Controlled Clinical Study
TI - Comparative Evaluation of Boric Acid Gel versus Chlorhexidine Gel in the
Treatment of Chronic Periodontitis: Randomized, Placebo-Controlled Clinical Study
VL - 10
Y2 - 7
ID - 14477
ER -
TY - JOUR
AN - rayyan-563561716
AU - Mamajiwala, A.
AU - Sethi, K.
AU - Mahale, S.
AU - Raut, C.
AU - Karde, P.
AU - Kale, A.
DO - 10.4103/ccd.ccd_752_18
IS - 3
PY - 2019
SP - 457-464
ST - Comparative evaluation of boric acid gel versus chlorhexidine gel in the
treatment of chronic periodontitis: Randomized, placebo-controlled clinical study
T2 - Contemporary Clinical Dentistry
TI - Comparative evaluation of boric acid gel versus chlorhexidine gel in the
treatment of chronic periodontitis: Randomized, placebo-controlled clinical study
85082074300&doi=10.4103%2fccd.ccd_752_18&partnerID=40&md5=ae536ab32e070bd04e0c59174
d973d37
VL - 10
ID - 15090
ER -
TY - JOUR
AB - Biofilms play an important role in the development and pathogenesis of many
chronic infections. Oral biofilms, more commonly known as dental plaque, are a
primary cause of oral diseases including caries, gingivitis, and periodontitis.
Oral biofilms are commonly studied as model biofilm systems as they are easily
accessible; thus, biofilm research in oral diseases is advanced with details of
biofilm formation and bacterial interactions being well elucidated. In contrast,
wound research has relatively recently directed attention to the role biofilms have
in chronic wounds. This review discusses the biofilms in periodontal disease and
chronic wounds with comparisons focusing on biofilm detection, biofilm formation,
the immune response to biofilms, bacterial interaction, and quorum sensing. Current
treatment modalities used by both fields and future therapies are also discussed. ©
2013 by the Wound Healing Society.
AN - rayyan-563560485
AU - Mancl, K. A.
AU - Kirsner, R. S.
AU - Ajdic, D.
DO - 10.1111/wrr.12034
IS - 3
KW - alkyldiaminoethylglycine
bacitracin zinc plus neomycin plus polymyxin B
benzalkonium chloride
mouthwash
povidone iodine
mupirocin
RNA 16S
RNA 18S
toothpaste
acne
alveolar bone
anaerobic bacterium
antibiotic therapy
atopic dermatitis
bacterium colony
biofilm
candidiasis
chronic wound
debridement
decubitus
diabetic foot
disease severity
fluorescence in situ hybridization
furunculosis
gene sequence
gingivitis
human
immune response
impetigo
in vitro study
in vivo study
leg ulcer
mouth disease
mouth hygiene
periodontitis
priority journal
quorum sensing
review
skin injury
species diversity
species identification
tooth brushing
tooth plaque
Treponema denticola
ultrasound therapy
wound healing
LA - English
PY - 2013
SN - ["1067-1927", "1524-475X"]
SP - 352-362
ST - Wound biofilms: Lessons learned from oral biofilms
T2 - Wound Repair Regen.
TI - Wound biofilms: Lessons learned from oral biofilms
VL - 21
ID - 13859
ER -
TY - JOUR
AB - According to research, skin aging results in a constant deteriorating process
due to protein and cellular DNA damage. The primary goal is to formulate an anti-
aging herbal cream utilizing only natural ingredients; Amla, curcuma longa,
hibiscus, pipper-mint, olive oil, vitamin E, green tea, coconut oil, aloe vera,
basil oil, and other natural APIs include pomegranate and ginseng. Natural
ingredients are used to create this water-in-oil emulsion-based cream. All of the
substances together can be considered a multifunctional cream, and further studies
on the cream's stability and irritancy on skin can be conducted.
AN - rayyan-563559926
AU - Mandal, R.
AU - Singh, R.
AU - Saini, A.
AU - Sharma, V.
AU - Sharma, M.
AU - Sharma, A. K.
AU - Madaan, V.
IS - 1
KW - alanine
aliiase
aloin
alpha tocopherol
alprogen
amino acid
amylase
anthocyanin
antidote
apigenin
apoptosis inducing factor
arginine
ascorbic acid
asistic acid
auxin
basil oil
beta sisosterol
calcium
calcium channel
carvacrol
caryophyllene
catalase
cholesterol
chromium
cineole
cirsilineol
coconut oil
copper
cosmetic
curcimaritin
cyanocobalamin
cyclooxygenase 2
decanoic acid
dithranol
ellagitannin
emodin
eriocitrin
essential oil
eugenol
flavone derivative
gallic acid
gel
gibberellin
gibberlin
ginseng extract
ginsenoside
ginsenoside Rb 1
ginsenoside Rb 2
ginsenoside Re
ginsenoside Rf
ginsenoside Rg 3
ginsenoside rh 1
glucose
glycine
glycoside
herbaceous agent
hesperidin
hexanoic acid
hydrocarbon
hypoxanthine
isothymusin
lauric acid
leucine
limonene
linoleic acid
linolenic acid
lupeol
lysine
manganese
mannan
menthofuran
menthol
menthone
menthyl acetate
methionine
methyl eugenol
myristic acid
octanoic acid
oleic acid
olive oil
oxidoreductase
palmitic acid
palmitoleic acid
peppermint oil
peroxisome proliferator activated receptor
peroxisome proliferator activated receptor delta
pilegone
pinene
polyacetylene derivative
polymannose
polysaccharide
pomegranate extract
potassium
prostaglandin E2
protopanaxadiol
punicalagin derivative
punicalin
punicic acid
pyridoxine
quercetin
retinol
riboflavin
rosameric acid
rutoside
salicylic acid
saponin
saturated fatty acid
selenium
sesquiterpine
sorbic acid
stearic acid
thiamine
triacylglycerol lipase
triterpenoid
unclassified drug
water oil cream
allergy
Aloe vera
analgesic activity
antiaging activity
antifungal activity
antipyretic activity
antitumorigenic activity
antiviral activity
arthritis
burn
cardiovascular risk
cestodiasis
chickenpox
cholesterol level
circulation
collagen synthesis
coughing
cream
Curcuma longa
cutaneous parameters
dermatitis
diabetes mellitus
diarrhea
digestive system function disorder
drug absorption
drug excretion
drug mechanism
drug metabolism
dyspnea
elasticity
face
gingivitis
ginseng
glucose blood level
heartburn
herbal medicine
Hibiscus
human
immune system
immunomodulation
Lamiaceae
leukoderma
liver protection
migraine
monocyte
mouth sore
muscle cramp
muscle spasm
nervousness
neuroprotection
nonhuman
Ocimum tenuiflorum
osteoarthritis
Phyllanthus emblica
pipper mint
pomegranate
prostate cancer
pruritus
rash
review
rhinorrhea
sensation
skin burning sensation
skin care
sore throat
swelling
tea
tinea
toxicity testing
tulsi
ulcer healing
urinary tract infection
water vapor
wound healing
LA - English
PY - 2022
SN - 0976-822X
SP - 10-16
ST - A REVIEW ON ANTI AGING HERBAL FACE CREAM
T2 - Intl. J. Curr. Pharm. Rev. Res.
TI - A REVIEW ON ANTI AGING HERBAL FACE CREAM
VL - 14
ID - 13300
ER -
TY - JOUR
AN - rayyan-563561198
AU - Mandel, I. D.
DO - 10.1111/j.1752-7325.1978.tb03756.x
IS - 4
fluoride
fluoride varnish
sucrose
toothpaste
article
carbohydrate diet
dental caries
fluoridation
forecasting
gel
health
history
microbiology
mouth hygiene
periodontal disease
research
science
sociology
tooth plaque
LA - English
PY - 1978
SN - 0022-4006
SP - 312-323
ST - Effectiveness of biomedical and biosocial research on improving oral health
T2 - J Public Health Dent
TI - Effectiveness of biomedical and biosocial research on improving oral health
VL - 38
ID - 14572
ER -
TY - JOUR
AB - Aloe vera (Aloe barbadensis) is a plant that belongs to Liliaceae family. The
name Aloe derives from the Arabic word «Alloeh» meaning shining bitter substance
while «vera» in Latin means true. It contains various minerals and vitamins. It has
got various properties such as immunomodulatory, antiviral and antiinflammatory in
nature. A. vera can play a significant role in dentistry in treatment of lichen
planus, oral submucous fibrosis, recurrent aphthous stomatitis, alveolar osteitis,
periodontitis, etc.
AN - rayyan-563560396
AU - Mangaiyarkarasi, S. P.
AU - Manigandan, T.
AU - Elumalai, M.
AU - Cholan, P.
AU - Kaur, R.
DO - 10.4103/0975-7406.155943
KW - adhesive agent
Aloe vera extract
amino acid
antioxidant
enzyme
gutta percha
lignin
placebo
salicylic acid
saponin
sterol
sugar
vitamin
abdominal cramp
allergy
Aloe vera
alveolar osteitis
aphthous stomatitis
burning sensation
constipation
deciduous tooth
dentistry
denture
diarrhea
drug efficacy
gel
gingivitis
hepatitis
human
lichen planus
mouth disease
nonhuman
oral mucositis
osteitis
periodontitis
plant nutrient
priority journal
review
tooth filling
tooth implant
LA - English
PY - 2015
SN - 0975-7406
SP - S255-S259
ST - Benefits of Aloe vera in dentistry
TI - Benefits of Aloe vera in dentistry
VL - 7
ID - 13770
ER -
TY - JOUR
AB - Background. Currently, the knowledge on the clinical effect of 4% mangosteen
gel as a local drug delivery, adjunctive to non-surgical periodontal therapy, on
the gingival crevicular fluid (GCF) total antioxidant capacity (TAOC) levels in
chronic periodontitis patients is limited. Objectives. The aim of the study was to
evaluate and compare the efficacy of 4% mangosteen gel and a placebo gel as an
adjunct to scaling and root planing (SRP) on clinical and biochemical parameters in
chronic periodontitis patients. Material and methods. A total of 50 test sites from
25 patients with Stage II Grade B periodontitis were randomly divided into 2
groups. The experimental group was treated with SRP followed by a single
subgingival application of 4% mangosteen gel, while the control group was treated
with SRP followed by a single subgingival application of a placebo gel. Clinical
parameters, including the plaque index (PI), the gingival bleeding index (GBI), the
probing depth (PD), the relative attachment level (RAL), as well as biochemical
parameters, i.e., the GCF TAOC levels, were evaluated using an ABTS (2,2’-Azino-
bis-3-ethylbenzothiazo-line-6-sulfonic acid) antioxidant assay kit at baseline (D0)
and at 3 months (D3). Results. The full-mouth PI and GBI values were significantly
lower at D3 in comparison with D3. The experimental sites showed a significantly
greater reduction in the PD and RAL scores as compared to control, and the GCF TAOC
levels revealed a substantial rise throughout the study period, reversing from
negative values at D0 to positive values at D3 in the experimental group.
Conclusions. Traditional SRP with the adjunctive local delivery of 4% mangosteen
gel demonstrated an added benefit in improving clinical and biochemical parameters,
and thereby encouraging the use of the mangosteen gel in clinical practice for the
management of moderate chronic periodontitis.
AN - rayyan-563559911
AU - Manjunatha, V. A.
AU - Vemanaradhya, G. G.
AU - Gowda, T. M.
DO - 10.17219/dmp/139198
IS - 1
KW - microplate reader
2,2' azinobis(3 ethylbenzothiazoline 6 sulfonic acid)
antioxidant
gel
mangosteen gel
placebo
unclassified drug
antioxidant assay
article
controlled study
dental scaling
gingiva bleeding
human
mouth plaque
plaque index
root planing
LA - English
PY - 2022
SN - ["2300-9020", "1644-387X"]
SP - 111-119
ST - Clinical and antioxidant efficacy of 4% mangosteen gel as a local drug
delivery in the treatment of chronic periodontitis: A placebo-controlled, split-
mouth trial
T2 - Dent. Med. Probl.
TI - Clinical and antioxidant efficacy of 4% mangosteen gel as a local drug
delivery in the treatment of chronic periodontitis: A placebo-controlled, split-
mouth trial
VL - 59
ID - 13285
ER -
TY - JOUR
AB - CONTEXT: Antimicrobial efficacy of subgingival chlorhexidine (CHX)
application using two different vehicles of delivery. AIMS: The aim was to evaluate
the efficacy of CHX varnish and gel as an adjunct to scaling and root planing (SRP)
in reducing microbial count within moderate to deep periodontal pockets. SETTINGS
AND DESIGN: Experimental parallel mouth study. SUBJECTS AND METHODS: A total of 30
subjects between the age groups 25 and 55 years having moderate to severe
periodontitis, with pocket depth ≥ 5 mm were selected for the study. The selected
patients were randomized into three groups of 10 each. Subjects in Group 1 received
SRP followed by subgingival application of CHX varnish, subjects in Group 2
received SRP followed by subgingival application of CHX gel, subjects in Group 3
received SRP alone. Subgingival plaque samples were collected to estimate mean
motile and nonmotile microbial counts using dark field microscopy at baseline, 1
week, 1 month, and 3 months. RESULTS: After 3 months, there was statistically
significant reduction in nonmotile microbial count in all the three groups. Motile
microbial count was significantly reduced in all the three groups till 1 month from
baseline. Only subjects in Group 1 who received subgingival CHXvarnish after SRP
showed a significant reduction in motile microbial count till 3 months from
baseline. CONCLUSIONS: Subgingival application of highly concentrated CHX varnish
following SRP is beneficial in reducing microbial count in moderate to deep
periodontal pockets.
AN - rayyan-563561134
AU - Manthena, S.
AU - Ramesh, A.
AU - Srikanth, A.
AU - Ramoji Rao, M. V.
AU - Preethi, P. L.
AU - Samatha, Y. P.
DO - 10.4103/0976-0105.145775
IS - 1
J2 - J Basic Clin Pharm
LA - eng
N1 - Department of Periodontics, Drs. Sudha and Nageswara Rao Siddhartha Institute
of Dental Sciences, Chinnoutpalli, India.; Department of Periodontics, A. B. Shetty
Memorial Institute of Dental Sciences, Deralakatte, Mangaluru, Karnataka, India.;
Department of Periodontics, Drs. Sudha and Nageswara Rao Siddhartha Institute of
Dental Sciences, Chinnoutpalli, India.; Department of Periodontics, Drs. Sudha and
Nageswara Rao Siddhartha Institute of Dental Sciences, Chinnoutpalli, India.;
Department of Periodontics, Drs. Sudha and Nageswara Rao Siddhartha Institute of
Dental Sciences, Chinnoutpalli, India.; Department of Periodontics, Drs. Sudha and
Nageswara Rao Siddhartha Institute of Dental Sciences, Chinnoutpalli, India.
PY - 2014
SN - 0976-0105 (Print)
SP - 24-8
ST - Comparative evaluation of subgingivally delivered chlorhexidine varnish and
chlorhexidine gel in reducing microbial count after mechanical periodontal therapy
T2 - Journal of basic and clinical pharmacy
TI - Comparative evaluation of subgingivally delivered chlorhexidine varnish and
VL - 6
Y2 - 12
ID - 14508
ER -
TY - JOUR
AB - Antimicrobial efficacy of subgingival chlorhexidine (CHX) application using
two different vehicles of delivery. Aims: The aim was to evaluate the efficacy of
CHX varnish and gel as an adjunct to scaling and root planing (SRP) in reducing
microbial count within moderate to deep periodontal pockets. Settings and Design:
Experimental parallel mouth study. Subjects and Methods: A total of 30 subjects
between the age groups 25 and 55 years having moderate to severe periodontitis,
with pocket depth ≥ 5 mm were selected for the study. The selected patients were
randomized into three groups of 10 each. Subjects in Group 1 received SRP followed
by subgingival application of CHX varnish, subjects in Group 2 received SRP
followed by subgingival application of CHX gel, subjects in Group 3 received SRP
alone. Subgingival plaque samples were collected to estimate mean motile and
nonmotile microbial counts using dark field microscopy at baseline, 1 week, 1
month, and 3 months. Results: After 3 months, there was statistically significant
reduction in nonmotile microbial count in all the three groups. Motile microbial
count was significantly reduced in all the three groups till 1 month from baseline.
Only subjects in Group 1 who received subgingival CHXvarnish after SRP showed a
significant reduction in motile microbial count till 3 months from baseline.
Conclusions: Subgingival application of highly concentrated CHX varnish following
SRP is beneficial in reducing microbial count in moderate to deep periodontal
pockets.
AN - rayyan-563560393
AU - Manthena, S.
AU - Ramesh, A.
AU - Srikanth, A.
AU - Ramoji Rao, M.
AU - Preethi, P.
AU - Samatha, Y.
DO - 10.4103/0976-0105.145775
IS - 1
KW - chlorhexidine
adult
article
bacterial count
clinical article
controlled study
female
gel
human
male
periodontal pocket
periodontitis
varnish
LA - English
PY - 2015
SN - ["0976-0113", "0976-0105"]
SP - 24-28
ST - Comparative evaluation of subgingivally delivered chlorhexidine varnish and
T2 - J. Basic Clin. Pharm.
TI - Comparative evaluation of subgingivally delivered chlorhexidine varnish and
VL - 6
ID - 13767
ER -
TY - JOUR
AB - The antibacterial efficacy of intracanal medication with calcium hydroxide
[Ca(OH)2], 2% chlorhexidine gel (CHX), and a combination of both [Ca(OH)2/CHX] was
assessed in teeth with chronic apical periodontitis. Thirty-three canals were
instrumented, randomly divided into three groups, and medicated with either
Ca(OH)2, CHX, or Ca(OH)2/CHX. Bacteriological samples obtained from the operative
field and the root canals before (S1) and after instrumentation (S2) in the first
treatment session, and after medication (S3) in the second session 1 week later,
were assessed for bacterial growth, observed by turbidity and in agar plates, and
viable colony-forming unit (CFU) counts. Bacterial growth and CFU counts decreased
significantly from S1 to S2 (Mann-Whitney, p < 0.05). Differences in growth and
counts between S2 to S3 were not statistically significant for all three intracanal
medication groups. It was concluded that the antibacterial efficacy of Ca(OH)2,
CHX, and Ca(OH)2/CHX was comparable. © 2007 American Association of Endodontists.
AN - rayyan-563560752
AU - Manzur, A.
AU - González, A. M.
AU - Pozos, A.
AU - Silva-Herzog, D.
AU - Friedman, S.
DO - 10.1016/j.joen.2006.11.003
IS - 2
calcium hydroxide
chlorhexidine
adolescent
adult
anaerobic bacterium
article
bacterial count
child
chronic disease
clinical trial
controlled study
drug combination
drug effect
endodontics
human
devices
methodology
microbiology
middle aged
nonparametric test
photometry
LA - English
PY - 2007
SN - 0099-2399
SP - 114-118
ST - Bacterial Quantification in Teeth with Apical Periodontitis Related to
Instrumentation and Different Intracanal Medications: A Randomized Clinical Trial
T2 - J. Endod.
TI - Bacterial Quantification in Teeth with Apical Periodontitis Related to
Instrumentation and Different Intracanal Medications: A Randomized Clinical Trial
VL - 33
ID - 14126
ER -
TY - JOUR
AB - The antibacterial efficacy of intracanal medication with calcium hydroxide
[Ca(OH)(2)], 2% chlorhexidine gel (CHX), and a combination of both [Ca(OH)(2)/CHX]
was assessed in teeth with chronic apical periodontitis. Thirty-three canals were
instrumented, randomly divided into three groups, and medicated with either Ca(OH)
(2), CHX, or Ca(OH)(2)/CHX. Bacteriological samples obtained from the operative
field and the root canals before (S1) and after instrumentation (S2) in the first
treatment session, and after medication (S3) in the second session 1 week later,
were assessed for bacterial growth, observed by turbidity and in agar plates, and
viable colony-forming unit (CFU) counts. Bacterial growth and CFU counts decreased
significantly from S1 to S2 (Mann-Whitney, p < 0.05). Differences in growth and
counts between S2 to S3 were not statistically significant for all three intracanal
medication groups. It was concluded that the antibacterial efficacy of Ca(OH)(2),
CHX, and Ca(OH)(2)/ CHX was comparable.
AN - rayyan-563562315
AU - Manzur, A.
AU - Gonzalez, A. M.
AU - Pozos, A.
AU - Silva-Herzog, D.
AU - Friedman, S.
DO - 10.1016/j.joen.2006.11.003
IS - 2
PY - 2007
SN - 0099-2399
SP - 114-118
ST - Bacterial quantification in teeth with apical periodontitis related to
instrumentation and different intracanal medications: A randomized clinical trial
TI - Bacterial quantification in teeth with apical periodontitis related to
instrumentation and different intracanal medications: A randomized clinical trial
VL - 33
Y2 - 2
ID - 15689
ER -
TY - JOUR
AB - In presence of large bone defects, delayed bone union, non-union, fractures,
and implant surgery, bone reconstruction may be necessary. Different strategies
have been employed to enhance bone healing among which the use of autologous
platelet concentrates. Due to the high content of platelets and platelet-derived
bioactive molecules (e.g., growth factors, antimicrobial peptides), they are
promising candidates to increase bone healing. However, a high heterogeneity of
both preclinical and clinical studies resulted in contrasting results. Aim of the
present systematic review was to evaluate the efficacy of platelet concentrates in
animal models of bone regeneration, considering the possible factors which might
affect the outcome. An electronic search was performed on MEDLINE and SCOPUS
databases. Animal studies with a minimum follow up of 2 weeks and a sample size of
five subjects per group, using platelet concentrates for bone regeneration, were
included. Articles underwent risk of bias assessment and further quality evaluation
was done. Sixty studies performed on six animal species (rat, rabbit, dog, sheep,
goat, and mini-pig) were included. The present part of the review considers only
studies performed on rats and rabbits (35 articles). The majority of the studies
were considered at medium risk of bias. Animal species, healthy models, platelet,
growth factors and leukocytes concentration, and type of bone defect seemed to
influence the efficacy of platelet concentrates in bone healing. However, final
conclusions were not be drawn, since only few included studies evaluated leukocyte,
growth factor content, or presence of other bioactive molecules in platelet
concentrates. Further studies with a standardized protocol including
characterization of the final products will provide useful information for clinical
application of platelet concentrates in bone surgery.
AN - rayyan-563562636
AU - Marcazzan, S.
AU - Weinstein, R. L.
AU - Del Fabbro, M.
DO - 10.1080/09537104.2017.1327652
IS - 4
PY - 2018
SN - ["0953-7104", "1369-1635"]
SP - 326-337
ST - Efficacy of platelets in bone healing: A systematic review on animal studies
T2 - PLATELETS
TI - Efficacy of platelets in bone healing: A systematic review on animal studies
VL - 29
ID - 16010
ER -
TY - JOUR
AB - Aim: The aim of this study was to determine the impact of different full-
mouth decontamination (FMD) protocols on the effectiveness of an intrapocket
anesthetic gel in periodontal maintenance patients. Methods: Patients undergoing
the periodontal maintenance program and with the need for FMD participated in this
study. Patients were randomly allocated to non-surgical periodontal therapy (NSPT)
with either a preparatory 15-day decontamination phase, including chlorhexidine
mouth rinse and domiciliary hygiene instructions (modified FMD: test group), or
without it (FMD: control group). In both groups, NSPT was performed with the aid of
a non-injectable anesthetic gel. Clinical and patient-related outcomes were
recorded during a 6-month follow-up period. Results: Sixty patients completed the
6-month study. Both groups experienced relevant clinical improvements after NSPT,
but the test group showed a significant change in periodontal parameters already
after the initial 15-day preparatory period, and overall significantly better
results in periodontal outcomes when compared with the control group at the last 6-
month follow up: the gingival index was 2.07 ± 1.25 in the control group and 1.13 ±
0.51 in the test group. Less pain and dental-related anxiety were perceived by
patients in the test group showing a 6-month mean visual analog scale of 2.13 ±
1.25 in the control group and 1.13 ± 0.83 in the test group. Conclusion: The
present study suggested that the modification of the standard FMD could improve the
clinical efficacy of non-injectable anesthetic, along with patients’ short- and
mid-term appreciation and compliance.
AN - rayyan-563560172
AU - Marconcini, S.
AU - Goulding, M.
AU - Oldoini, G.
AU - Attanasio, C.
AU - Giammarinaro, E.
AU - Genovesi, A.
DO - 10.1111/jicd.12446
IS - 4
KW - adult
anxiety
article
controlled study
decontamination
female
follow up
gingiva
gingival index
human
hygiene
male
pain
visual analog scale
chlorhexidine
mouthwash
LA - English
PY - 2019
SN - ["2041-1626", "2041-1618"]
ST - Clinical and patient-centered outcomes post non-surgical periodontal therapy
with the use of a non-injectable anesthetic product: A randomized clinical study
T2 - J. Investig. Clin. Dent.
TI - Clinical and patient-centered outcomes post non-surgical periodontal therapy
with the use of a non-injectable anesthetic product: A randomized clinical study
VL - 10
ID - 13546
ER -
TY - JOUR
AB - AimTo investigate the influence of auxiliary chemical substances (ACSs) and
calcium hydroxide [Ca(OH)(2)] dressings on lipopolysaccharides (LPS)/lipid A
detection and its functional ability in activating Toll-like receptor 4 (TLR4).
MethodologyFusobacterium nucleatum pellets were exposed to antimicrobial agents as
following: (i) ACS: 5.25%, 2.5% and 1% sodium hypochlorite solutions (NaOCl), 2%
chlorhexidine (CHX) (gel and solution) and 17% ethylenediaminetetraacetic acid
(EDTA); (ii) intracanal medicament: Ca(OH)(2) paste for various periods (1h, 24h,
7days, 14days and 30days); (iii) combination of substances: (a) 2.5% NaOCl (1h),
followed by 17% EDTA (3min) and Ca(OH)(2) (7days); (b) 2% CHX (1h), afterwards, 17%
EDTA (3min) followed by Ca(OH)(2) (7days). Saline solution was the control. Samples
were submitted to LPS isolation and lipid A purification. Lipid A peaks were
assessed by matrix-assisted laser desorption ionization time-of-flight mass
spectrom (MALDI-TOF MS) whilst LPS bands by SDS-PAGE separation and silver
staining. TLR4 activation determined LPS function activities. Statistical
comparisons were carried out using one-way anova with Tukey-Kramer post-hoc tests
at the 5% significance level. ResultsMatrix-assisted laser desorption ionization
time-of-flight mass spectrometry analysis of control lipid A demonstrated the ion
cluster at mass/charge (m/z) 1882 and an intense band in SDS-PAGE followed by
silver staining of control LPS. In parallel, LPS control induced a robust TLR4
activation when compared to ACS (P.001). 5.25% NaOCl treatment led to the absence
of lipid A peaks and LPS bands, whilst no changes occurred to lipid A/LPS after
treatment with others ACS. Concomitantly, 5.25% NaOCl-treated LPS did not activate
TLR4 (P<.0001). As for Ca(OH)(2), lipid A was not detected by MALDI-TOF nor by gel
electrophoresis within 24h. LPS treated with Ca(OH)(2) was a weak TLR4 activator
(P<.0001). From 24h onwards, no significant differences were found amongst the time
periods tested (P>0.05). The addition of Ca(OH)(2) for 7days to cells treated
either with 2.5% NaOCl or 2% CHX led to the absence of lipid A peaks and LPS bands,
leading to a lower activation of TLR4. Conclusion5.25% NaOCl and Ca(OH)(2)
dressings from 24h onwards were able to induce both, loss of lipid A peaks and no
detection of LPS bands, rendering a diminished immunostimulatory activity through
TLR4.
AN - rayyan-563562613
AU - Marinho, A. C. S.
AU - To, T. T.
AU - Darveau, R. P.
AU - Gomes, Bpfa
DO - 10.1111/iej.12920
IS - 10
PY - 2018
SN - ["0143-2885", "1365-2591"]
SP - 1118-1129
ST - Detection and function of lipopolysaccharide and its purified lipid A after
treatment with auxiliary chemical substances and calcium hydroxide dressings used
in root canal treatment
TI - Detection and function of lipopolysaccharide and its purified lipid A after
treatment with auxiliary chemical substances and calcium hydroxide dressings used
in root canal treatment
VL - 51
Y2 - 10
ID - 15987
ER -
TY - JOUR
AB - RESULTS: Porphyromonas gingivalis (17/30), Porphyromonas endodontalis
(15/30), and Prevotella nigrescens (11/30) were the most prevalent bacterial
species. At s1, endotoxins were detected in 100% of the root canals (median = 32.43
EU/mL). In parallel, substantial amounts of IL-1β and TNF-α were produced by
endodontic content-stimulated macrophages. At s2, a significant reduction in
endotoxin levels was observed in all groups, with GI presenting the greatest
reduction (P < .05). After a root canal rinse with EDTA (s3), intracanal medication
(s4), and before root canal obturation (s5), endotoxin levels reduced without
differences between groups (P < .05). IL-1β and TNF-α release decreased
proportionally to the levels of residual endotoxin (P < .05). INTRODUCTION: This
study investigated the presence of target bacterial species and the levels of
endotoxins in teeth with apical periodontitis. Levels of inflammatory mediators
(interleukin [IL]-1β and tumor necrosis factor [TNF]-α) were determined after
macrophage stimulation with endodontic content after different phases of endodontic
therapy using different irrigants. METHODS: Thirty primarily infected root canals
were randomly assigned into 3 groups according to the irrigant used for root canal
preparation (n = 10 per group): GI: 2.5% sodium hypochlorite, GII: 2% chlorhexidine
gel, and GIII (control group): saline solution. Root canal samples were taken by
using paper points before (s1) and after root canal instrumentation (s2),
subsequently to 17% EDTA (s3), after 30 days of intracanal medication (Ca[OH]2 +
saline solution) (s4), and before root canal obturation (s5). Polymerase chain
reaction (16S recombinant DNA) and limulus amebocyte lysate assay were used for
bacterial and endotoxin detection, respectively. Macrophages were stimulated with
the root canal contents for IL-1β/TNF-α measurement using enzyme-linked
immunosorbent assay. CONCLUSIONS: Regardless of the use of sodium hypochlorite or
CHX, the greatest endotoxin reduction occurs after chemomechanical preparation.
Increasing steps of root canal therapy associated with intracanal medication
enhances endotoxin reduction, leading to a progressively lower activation of
proinflammatory cells such as macrophages.
AN - rayyan-563560383
AU - Marinho, A. C.
AU - Leite, F. R.
AU - Nascimento, G. G.
AU - Gomes, B. P.
DO - 10.1016/j.joen.2015.01.017
IS - 6
chlorhexidine
hypochlorite sodium
interleukin 1beta
lipopolysaccharide
controlled study
drug effect
human
immunology
macrophage activation
microbiology
Porphyromonas endodontalis
procedures
LA - English
PY - 2015
SN - 1878-3554
SP - 817-823
ST - Proinflammatory Activity of Primarily Infected Endodontic Content against
Macrophages after Different Phases of the Root Canal Therapy
T2 - J Endod
TI - Proinflammatory Activity of Primarily Infected Endodontic Content against
Macrophages after Different Phases of the Root Canal Therapy
VL - 41
ID - 13757
ER -
TY - JOUR
AB - RESULTS: Endotoxins were detected in 100% of the root canals investigated
(30/30), with a median value of 18.70 EU/mL. After S2, significant median
percentage reduction was observed in all groups, irrespective of the irrigant
tested: 2.5% NaOCl (99.65%) (GI), 2% CHX (94.27%) (GII), and SS (96.79%) (GIII)
(all p<0.05). Root canal rinse with 17% EDTA (S3) for a 3-minute period failed to
decrease endotoxin levels in GI and a slight decrease was observed in GII (59%) and
GIII (61.1%) (all p>0.05). Intracanal medication for 30 days was able to
significantly reduce residual endotoxins: 2.5% NaOCl (90%) (GI), 2% CHX (88.8%)
(GII), and SS (85.7%) (GIII, p<0.05). No differences were found in the endotoxin
reduction when comparing s2 and s4 treatment groups. CONCLUSION: Our findings
demonstrated the effectiveness of the mechanical action of the instruments along
with the flow and backflow of irrigant enduring root canal instrumentation for the
endotoxin removal from root canals of teeth with chronic apical periodontitis.
Moreover, the use of intracanal medication for 30 days contributed for an
improvement of endotoxin reduction. OBJECTIVE: The aim of this study was to monitor
the effectiveness of root canal procedures by using different irrigants and
intracanal medication on endotoxin levels found in root canals of teeth with
chronic apical periodontitis. MATERIAL AND METHODS: Thirty root canals of teeth
with pulpal necrosis associated with periapical lesions were selected and randomly
divided into groups according to the irrigants used: GI - 2.5% NaOCl, GII - 2%
chlorhexidine (CHX) gel, and GIII - saline solution (SS) (all, n=10). Samples were
collected with sterile/apyrogenic paper points before (S1) and after root canal
instrumentation (S2), after use of 17% ethylenediaminetetraacetic acid (EDTA) (S3),
and after 30 days of intracanal medication (Ca(OH)2+SS) (S4). A turbidimetric
kinetic Limulus Amebocyte Lysate assay was used for endotoxin measurement.
AN - rayyan-563560416
AU - Marinho, A. C.
AU - Zaia, A. A.
AU - Ferraz, C. C.
AU - Gomes, B. P.
DO - 10.1590/1678-775720130664
IS - 6
chlorhexidine
edetic acid
hypochlorite sodium
lipopolysaccharide
chronic disease
endodontics
human
Limulus lysate test
microbiology
nonparametric test
procedures
randomization
time
tooth pulp disease
treatment outcome
LA - English
PY - 2014
SN - 1678-7765
SP - 490-495
ST - Monitoring the effectiveness of root canal procedures on endotoxin levels
found in teeth with chronic apical periodontitis
T2 - J Appl Oral Sci
TI - Monitoring the effectiveness of root canal procedures on endotoxin levels
found in teeth with chronic apical periodontitis
VL - 22
ID - 13790
ER -
TY - JOUR
AB - Hyaluronic acid (HA) is a natural polymer, produced endogenously by the human
body, which has unique physicochemical and biological properties, exhibiting
desirable biocompatibility and biodegradability. Therefore, it has been widely
studied for possible applications in the area of inflammatory diseases. Although
exogenous HA has been described as unable to restore or replace the properties and
activities of endogenous HA, it can still provide satisfactory pain relief. This
review aims to discuss the advances that have been achieved in the treatment of
inflammatory diseases using hyaluronic acid as a key ingredient, essentially
focusing on studies carried out between the years 2017 and 2021.
AN - rayyan-563559955
AU - Marinho, A.
AU - Nunes, C.
AU - Reis, S.
DO - 10.3390/biom11101518
IS - 10
KW - adipic acid dihydrazide
aggrecanase 2
Aloe vera extract
alpha interferon
brain derived neurotrophic factor
budesonide
calcineurin inhibitor
carnosine
cartilage oligomeric matrix protein
celecoxib
cell surface receptor
collagenase 3
corticosteroid
cyclooxygenase 2
cytokine response modifier A
dexamethasone
diclofenac
dk 226 inhibitor
gengigel
glycosylphosphatidylinositol
Hermes antigen
hyaladherin
hyaluronate synthetase
hyaluronate synthetase 1
hyaluronic acid
hyaluronic acid link protein
hydrogel
ibuprofen
intercellular adhesion molecule 1
interleukin 10
interleukin 6
interleukin 8
liposomes loaded with celecoxib
lymphatic vessel endothelial receptor 1
magnoflorine
matrix metalloprotein
membrane receptor
mesalazine
methotrexate
nanocapsule
nanohydroxyapatite
nanoparticle
nerve growth factor
polymer
prednisolone
salazosulfapyridine
somatomedin binding protein 3
stabilin 2
stromelysin
tacrolimus
teriflunomide
toll like receptor
unclassified drug
xanthine oxidase
analgesia
antigen-induced arthritis
atopic dermatitis
biocompatibility
biodegradability
biological activity
biosynthesis
Caco-2 cell line
carditis
cartilage degeneration
cell proliferation
chemical structure
chondrogenesis
chronic arthritis
cystitis
dermal fibroblast
endocytosis
endothelium cell
extracellular space
gingivitis
glycosidic bond
gout
hemolysis
human
hydration
hydrogen bond
immunogenicity
inflammation
Intervertebal disc injury
irradiation
Manuka honey
molecular weight
nephritis
nonhuman
osteoarthritis
physical chemistry
review
synovitis
temporomandibular joint
tendinitis
thermal hyperalgesia
tissue regeneration
viscoelasticity
vitreous body
wettability
wound healing
LA - English
PY - 2021
SN - 2218-273X
ST - Hyaluronic acid: A key ingredient in the therapy of inflammation
T2 - Biomolecules
TI - Hyaluronic acid: A key ingredient in the therapy of inflammation
VL - 11
ID - 13329
ER -
TY - JOUR
AB - Atrophy or hypofunction of the salivary gland because of aging, radiotherapy
or disease causes hyposalivation and impairs the quality of life of patients by
compromising mastication, swallowing and speech and by leading to a loss of taste.
Moreover, hyposalivation exacerbates dental caries and induces periodontal disease,
and oral candidiasis. Currently, no satisfactory therapies have been established to
solve salivary hypofunction. Current treatment options for atrophy or hypofunction
of the salivary glands in clinical practice are only symptomatic and include saliva
substitutes and parasympathetic agonists, such as pilocarpine, to stimulate
salivary flow. However, parasympathomimetics have systemic side effects, so
different treatment options are necessary, and research has recently focused on
this. The main strategies that have been proposed to restore salivary gland atrophy
and hypofunction are gene therapy by gene activation/silencing during stem cell
differentiation and by the use of viral vectors, such as adenoviruses; cell-based
therapy with salivary gland cells, stem cells and non-salivary gland and/ or non-
epithelial cells to regenerate damaged salivary gland cells; replacement with
tissue bioengineering in which organoids from pluripotent stem cells are used in
the development of organ replacement regenerative therapy. Remarkable progression
in this research field has been made in the last decade, but a definitive therapy
for salivary gland hypofunction has not been developed due to intrinsic challenges
that come with each approach. However, with research efforts in the future, a range
of precision medicine therapies may become available individualized to each
patient.
AN - rayyan-563560144
AU - Marrosu, V.
AU - Carta, F.
AU - Quartu, D.
AU - Tatti, M.
AU - Mariani, C.
AU - De Seta, D.
AU - Puxeddu, R.
AU - Angeletti, D.
AU - Campo, F.
AU - Petrone, P.
AU - Spinato, G.
AU - Scarpa, A.
AU - Molteni, G.
AU - Mannelli, G.
AU - Capasso, P.
AU - Ralli, M.
AU - Casoli, V.
AU - Barbara, F.
AU - Dadduzio, S.
AU - Berardi, A.
AU - Berardi, C.
DO - 10.36150/2499-6564-489
IS - 2
KW - insulin pump
aldehyde dehydrogenase
anethole
anethole trithione
castor oil
cetirizine
cevimeline
chitosan
extra virgin olive oil
hyaluronic acid
hydrochlorothiazide
hydrogel
immunoglobulin A
interleukin 1beta
interleukin 6
lipoxygenase
loratadine
nose spray
nutraceutical
pilocarpine
prazosin
prednisone
propranolol
protein p53
secretory immunoglobulin
serotonin uptake inhibitor
sucralose
yohimbine
acupuncture
amyloidosis
atrophy
bacterial infection
caloric restriction
cell aging
cell therapy
DNA damage
genetic modification
dry nose
dysphagia
erythema
gene therapy
human
hypersalivation
hyposalivation
mastication
nonhuman
organogenesis
otorhinolaryngology
periodontal disease
pluripotent stem cell
pneumonia
quality of life
review
rhinitis
salivary gland
salivation
sarcoidosis
senescence
Sjoegren syndrome
substitution therapy
swallowing
sweating
thrush
tissue engineering
xerostomia
LA - English
PY - 2020
SN - 2499-6564
SP - 113-121
ST - The secretory senescence in otorhinolaryngology: Principles of treatment
T2 - J. Gerontology Geriatrics
TI - The secretory senescence in otorhinolaryngology: Principles of treatment
VL - 68
ID - 13518
ER -
TY - JOUR
AB - OBJECTIVE To compare improvements in values for periodontal disease indices
in dogs following treatment with closed root planing (CRP) alone, CRP with
concurrent 8.5% doxycycline hyclate gel application, and CRP with concurrent 2%
clindamycin hydrochloride reverse-polymer hydrogel application. DESIGN Randomized,
blinded, controlled clinical trial. ANIMALS 34 client-owned dogs with periodontal
pockets measuring 3.5 to 5.5 mm deep. PROCEDURES Dogs were randomly assigned to
receive 1 of 3 treatments: CRP alone (n = 10) or CRP plus 8.5% doxycycline hyclate
(12) or 2% clindamycin hydrochloride (12) gel applied within the periodontal
pockets. Indices of periodontal disease severity were recorded before and 12 weeks
after treatment, and outcomes were compared among treatment groups. RESULTS Except
for gingivitis index, no significant differences were identified among the 3
treatment groups in the amount of improvement observed in values for periodontal
disease indices following treatment. A minor but clinically unimportant improvement
in mean gingivitis index values was identified for dogs treated with CRP plus
doxycycline gel, which differed significantly from improvements in the other 2
groups. Teeth that were initially more severely affected (pocket depths, 5.0 to 5.5
mm) had the greatest amount of improvement, whereas teeth with only mildly high
initial pocket depths (3.5 to 4.0 mm) had less improvement. CONCLUSIONS AND
CLINICAL RELEVANCE Overall, addition of doxycycline or clindamycin gel application
to CRP for the treatment of periodontal disease in dogs yielded no clinically
relevant benefit over CRP during the 12-week follow-up period.
AN - rayyan-563560203
AU - Martel, D. P.
AU - Fox, P. R.
AU - Lamb, K. E.
AU - Carmichael, D. T.
DO - 10.2460/javma.254.3.373
IS - 3
KW - clindamycin
doxycycline hyclate
article
controlled study
dental curettage
disease severity
dog
drug efficacy
female
gingivitis
hydrogel
nonhuman
periodontal disease
root planing
LA - English
PY - 2019
SN - ["1943-569X", "0003-1488"]
SP - 373-379
ST - Comparison of closed root planing with versus without concurrent doxycycline
hyclate or clindamycin hydrochloride gel application for the treatment of
periodontal disease in dogs
T2 - J. Am. Vet. Med. Assoc.
TI - Comparison of closed root planing with versus without concurrent doxycycline
hyclate or clindamycin hydrochloride gel application for the treatment of
periodontal disease in dogs
VL - 254
ID - 13577
ER -
TY - JOUR
AB - With respect to oral hygiene, most of the handicapped are very dependent.
Moreover, it is shown that the higher the dexterity level, the poorer the oral
hygiene. It's well documented that the use of Chlorhexidine (CHX) is an essential
tool in oral care for the handicapped. The efficacy however, only becomes optimal
after thorough plaque and calculus removal. From the literature, it becomes clear
that the application of a 1% gel in prefabricated trays is the most efficient.
Regarding mouthrinses, it's important to use big volumes in order to reach optimal
contact with tooth surfaces. The use of a spray seems very handy but is quiet
inefficient; no homogeneous diffusion of CHX can be obtained. The choice of any
device for CHX application depends on the handicapping condition and on the
knowledge and motivation of educators, and medical care takers. The present article
summarizes the dental literature on the use of CHX in handicapped. An advice for
well indicated use of CHX is proposed.
AN - rayyan-563561036
AU - Martens, L.
AU - Marks, L.
AU - Kint, J.
IS - 2
KW - chlorhexidine
aerosol
attitude to health
caregiver
dental procedure
disabled person
disinfection
gel
human
microbiology
motivation
mouth hygiene
periodontal disease
review
tooth calculus
tooth plaque
tooth prosthesis
LA - French
PY - 1997
SN - 0035-080X
SP - 27-37
ST - The use of chlorhexidine as a preventive and therapeutic means of plaque
control in the handicapped. Review of the literature and definitive advise for
application
T2 - L'utilisation de la chlorhexidine comme moyen de contrôle de plaque préventif
et thérapeutique chez l'handicapé. Aperçu de la littérature et Conseils concrets
d'application.
TI - The use of chlorhexidine as a preventive and therapeutic means of plaque
control in the handicapped. Review of the literature and definitive advise for
application
VL - 52
ID - 14410
ER -
TY - JOUR
AB - OBJECTIVES: This RCT investigated the impact of N-acetylcysteine (NAC) and
calcium hydroxide [Ca(OH)2] intracanal medications (ICMs) in primary endodontic
infection with apical periodontitis (PEIAP). MATERIALS AND METHODS: Thirty-six
teeth with PEIAP were randomly divided into groups according to the ICM: NAC,
Ca(OH)2 + saline solution (SSL), and Ca(OH)2 + 2% chlorhexidine-gel (2% CHX-gel)
(all, n = 12). Root canal samples (RCSs) were collected before (s1) and after
instrumentation (s2) and after 14 days of ICM (s3). Chemomechanical preparation
(CMP) was performed with a Reciproc file and 2.5% NaOCl. Checkerboard DNA-DNA
hybridization was used to assess 40 target bacteria species. RESULTS: At s1,
bacterial DNA was detected in 100% of RCSs (36/36). All 40 bacterial species were
found in PEIAP. The mean number of species per RCS was 17.92 ± 13.18. The most
frequent bacteria were S. mitis (65%), E. nodatum (63%), E. faecalis (63%), F. nucl
sp vicentii (58%), T. forsythia (58%), and F. periodonticum (56%). CMP reduced the
mean number of species per RCS to 6.8 ± 2.36 (p < 0.05). At s3, the intragroup
analysis revealed a broader antimicrobial activity for Ca (OH)2 + 2% CHX-gel and
NAC than Ca(OH)2 + SSL (p < 0.05). NAC eliminated 8/12 bacteria species resistant
to both Ca (OH)2 ICMs, including P. micra, P. nigrescens, T. denticola, A.
israelii, P. endodontalis, P. acnes, C. ochracea, and E. corrodens. CONCLUSIONS: Ca
(OH)2 + 2% chlorhexidine gel (2% CHX gel) showed a greater bacterial elimination
over the number of bacterial species; however, NAC eliminated 8/12 bacteria species
resistant to both Ca (OH)2 ICMs (RBR-3xbnnn). CLINICAL RELEVANCE: The use of
intracanal medication with a broad antimicrobial activity can optimize root canal
disinfection. Ca(OH)2 + 2% CHX gel and NAC showed a broader antimicrobial activity
than Ca(OH)2 + SSL against endodontic pathogens in primary root canal infection.
TRIAL REGISTRATION: Brazilian Registry of Clinical Trials (REBEC), No. RBR-3xbnnn.
AN - rayyan-563559752
AU - Khoury, R. D.
AU - Orozco, E. I. F.
AU - Toia, C. C.
AU - Machado, F. P.
AU - Valera, M. C.
DO - 10.1007/s00784-022-04585-9
IS - 2
KW - acetylcysteine
calcium hydroxide
chlorhexidine
DNA
bacterium
controlled study
dental pulp cavity
human
microbiology
LA - English
PY - 2023
SN - 1436-3771
SP - 817-826
ST - Impact of N-acetylcysteine (NAC) and calcium hydroxide intracanal medications
in primary endodontic infection: a randomized clinical trial
TI - Impact of N-acetylcysteine (NAC) and calcium hydroxide intracanal medications
in primary endodontic infection: a randomized clinical trial
VL - 27
ID - 13126
ER -
TY - JOUR
AB - METHODS: Thirty primarily infected teeth were randomly divided into 3 groups
according to the medication selected: chlorhexidine (CHX), 2% CHX gel; Ca(OH)2/SSL,
Ca(OH)2 + SSL; and Ca(OH)2/CHX, Ca(OH)2 + 2% CHX gel (all, n = 10). Bacterial
sample was collected from root canals, and the interstitial fluid was sampled from
lesions. Culture techniques were used to determine bacterial counts (colony-forming
units/mL). Th1 (tumor necrosis factor-α, interferon-γ, and interleukin [IL]-2) and
Th2 cytokines (IL-4, IL-5, and IL-13) were measured by enzyme-linked immunosorbent
assay. RESULTS: All intracanal medication protocols were effective in reducing the
bacterial load from root canals (all P < .05) and lowering the levels of Th1-type
cytokines in apical lesions (all P < .05), with no differences between them (P
> .05). Both Ca(OH)2 treatment protocols significantly increased the levels of Th2-
type cytokines (P < .05), with no differences between them (P > .05). Thus,
chlorhexidine medication showed the lowest effectiveness in increasing the levels
of Th2-type cytokine. After treatment, regardless of the type of medication, the
linear regression analysis indicated the down-regulation of Th2-type cytokines by
Th1-type cytokines. CONCLUSIONS: All intracanal medication protocols were effective
in reducing bacterial load and lowering the levels of Th1-type cytokines. Thus, the
use of Ca(OH)2 medications contributed to the increase in the Th2-type cytokine
response in apical periodontitis. INTRODUCTION: This clinical study assessed the
influence of different intracanal medications on Th1-type and Th2-type cytokine
responses in apical periodontitis and monitored the levels of bacteria from
primarily infection during endodontic procedures.
AN - rayyan-563560390
AU - Leite, F. R.
AU - Gomes, A. P.
AU - Freitas, L. F.
AU - Camões, I. C.
DO - 10.1016/j.joen.2014.09.028
IS - 2
chlorhexidine
gamma interferon
IL4 protein, human
interleukin 2
interleukin 4
bacterial load
drug effect
human
metabolism
microbiology
pathology
procedures
Th1 Th2 balance
LA - English
PY - 2015
SN - 1878-3554
SP - 169-175
ST - Clinical influence of different intracanal medications on Th1-type and Th2-
type cytokine responses in apical periodontitis
T2 - J Endod
TI - Clinical influence of different intracanal medications on Th1-type and Th2-
type cytokine responses in apical periodontitis
VL - 41
ID - 13764
ER -
TY - JOUR
AB - In the present investigation, a scanning electron microscopy analysis was
performed to evaluate the effects of the topical application of
ethylenediaminetetraacetic acid (EDTA) gel associated with Cetavlon (EDTAC) in
removing the smear layer and exposing collagen fibers following root surface
instrumentation. Twenty-eight teeth from adult humans, single rooted and scheduled
for extraction due to periodontal reasons, were selected. Each tooth was submitted
to manual (scaling and root planing) instrumentation alone or combined with
ultrasonic instruments, with or without etching using a 24 EDTAC gel. Following
extraction, specimens were processed and examined under a scanning electron
microscope. A comparative morphological semi-quantitative analysis was performed;
the intensity of the smear layer and the decalcification of cementum and dentinal
surfaces were graded in 12 sets using an arbitrary scale ranging from 1 (area
covered by a smear layer) to 4 (no smear layer). Root debridement with hand
instruments alone or combined with ultrasonic instruments resulted in a similar
smear layer covering the root surfaces. The smear layer was successfully removed
from the surfaces treated with EDTAC, which exhibited numerous exposed dentinal
tubules and collagen fibers. This study supports the hypothesis that manual
instrumentation alone or instrumentation combined with ultrasonic instrumentation
is unable to remove the smear layer, whereas the subsequent topical application of
EDTAC gel effectively removes the smear layer, uncovers dentinal openings and
exposes collagen fibers. © 2011 The Author Published by Oxford University Press [on
behalf of Japanese Society of Microscopy]. All rights reserved.
AN - rayyan-563560599
AU - Martins Júnior, W.
AU - De Rossi, A.
AU - Samih Georges Abi Rached, R.
AU - Rossi, M. A.
DO - 10.1093/jmicro/dfq083
IS - 2
KW - cetrimide
chelating agent
edetic acid
adult
article
dental surgery
evaluation study
gel
human
methodology
pathology
periodontal disease
tooth root
ultrasound therapy
ultrastructure
LA - English
PY - 2011
SN - ["0022-0744", "1477-9986"]
SP - 167-175
ST - A scanning electron microscopy study of diseased root surfaces conditioned
with EDTA gel plus Cetavlon after scaling and root planing
T2 - J. Electron Microsc.
TI - A scanning electron microscopy study of diseased root surfaces conditioned
with EDTA gel plus Cetavlon after scaling and root planing
VL - 60
ID - 13973
ER -
TY - JOUR
AB - Objectives: The purpose of this study was to evaluate the effect of
subgingival administration of doxycycline as an adjunct to periodontal therapy in
type 1 diabetes mellitus (DM) patients. Material and methods: Twenty-two paired
periodontal defects ≥5.0 mm were treated in 11 patients (35-55 years old). After
initial therapy the sites were randomly assigned into test (scaling and root
planing+subgingival administration of 10% doxycycline hyelate gel) or control
(scaling and root planing+subgingival placebo gel) groups. The clinical parameters
of clinical attachment level (CAL), probing depth (PD) and gingival margin level
(GML) for recession determination were assessed at baseline, after 6 weeks, and 6,
9 and 12 months, using a computerized probe. Data were statistically evaluated
using Duncan and F tests. Results: Between study group comparisons indicated PD
reduction and CAL gain were greater in the test group than in the control group at
6 weeks and 6, 9 and 12 months but only statistically significant at 12 months (p
<0.05). Within study group comparisons indicated statistically significant
differences were found for CAL and PD values favouring the adjunctive doxycycline
group from baseline to 6 weeks and 6, 9 and 12 months (p <0.05). Conclusions: These
findings suggest that subgingivally delivered doxycycline hyclate produces
additional favorable clinical results to periodontal therapy in type 1 DM patients.
© Blackwell Munksgaard, 2004.
AN - rayyan-563560862
AU - Martorelli De Lima, A. F.
AU - Cury, C. C.
AU - Palioto, D. B.
AU - Duro, A. M.
AU - Da Silva, R. C.
AU - Wolff, L. F.
DO - 10.1111/j.0303-6979.2004.00576.x
IS - 8
KW - doxycycline
adult
article
automation
clinical article
clinical trial
controlled study
drug effect
drug formulation
evaluation study
gel
gingiva
human
insulin dependent diabetes mellitus
periodontal disease
periodontitis
treatment outcome
LA - English
PY - 2004
SN - 0303-6979
SP - 648-653
ST - Therapy with adjunctive doxycycline local delivery in patients with type 1
diabetes mellitus and periodontitis
TI - Therapy with adjunctive doxycycline local delivery in patients with type 1
diabetes mellitus and periodontitis
VL - 31
ID - 14236
ER -
TY - JOUR
AB - Control of subgingival plaque is the key of the treatment of periodontal
diseases. The use of subgingival sustained-release antibiotic therapy is advocated
for the beneficial effect on anaerobic flora. A single-blind clinical trial was
carried out in 13 patients with adult periodontitis to compare the effects of
subgingival application of metronidazole dental gel with those of subgingival
scaling. METHOD AND MATERIALS: A split mouth design was used so that each patient
received all treatments simultaneously. Randomly selected quadrants were treated
with applications of 25% metronidazole gel, subgingival scaling, or a combination
of scaling and gel application. The remaining quadrant in each patient was left
untreated as a control. RESULTS: All three treatments were effective in
significantly reducing bleeding on probing over the 14 weeks observation period. No
statistically significant differences were found between scaling alone and combined
treatment. Scaling and combined treatment were better than metronidazole.
Metronidazole produced transient effects, best noted during the first 4 weeks after
treatment. No additive effect of metronidazole was noted in the combined treatment.
At week 14, only combined treatment sites and scaled showed statistically greater
probing depths reduction than control sites. CONCLUSION: For the treatment of mild
to moderate adult periodontitis, subgingival scaling alone is as effective as the
combination of scaling and antibiotic therapy.
AN - rayyan-563560990
AU - Mârţu, S.
AU - Mocanu, C.
AU - Popovici, C. G.
IS - 2
metronidazole
adult
article
clinical trial
comparative study
controlled study
gel
human
methodology
middle aged
periodontics
periodontitis
LA - Romanian
PY - 2000
SN - 0300-8738
SP - 125-130
ST - Comparison on the effects of metronidazole in subgingival application in the
treatment of adult periodontitis
T2 - Studiul comparativ al efectului metronidazolului în aplicaţii subgingivale în
tratamentul parodontitei adultului.
TI - Comparison on the effects of metronidazole in subgingival application in the
treatment of adult periodontitis
VL - 104
ID - 14364
ER -
TY - JOUR
AB - Background and Objectives: This study compared the surface morphology as well
as the biocompatibility of dental root cementum treated with Er:YAG laser
irradiation alone and with the laser irradiation followed by chemical and/or
mechanical conditioning. Study Design/Materials and Methods: Healthy cementum
plates were randomly assigned to the following control and treatment groups: (1)
untreated control (C), (2) Er:YAG laser irradiation (L), (3) laser plus
tetracycline HCl (TC) placement (L+TP), (4) laser plus TC burnishing (L+TB), (5)
laser plus EDTA gel placement (L+EP), (6) laser plus EDTA gel burnishing (L+EB),
(7) laser plus saline solution burnishing (L+SB), and (8) laser plus minocycline-
HCl paste placement (L+MP). Specimens were subjected to scanning electron
microscopy (SEM), histological observation and attachment assay using periodontal
ligament (PDL) fibroblasts. Results: The laser irradiation produced a thin affected
layer (5.7 μm thickness) with a superficial microstructure on the cementum surface.
The characteristic microstructures of the lased surface were fragile and could be
removed by chemical and/or mechanical conditioning treatments. The L+TB group
exhibited marked exposure of collagen fibers after removal of the microstructures
on the lased surface. The L+EP group presented a peculiar, smooth surface without
exposure of collagen fibers and a uniform arrangement of spherical microparticles
on the ultra-high magnification of SEM. In cell attachment assay, the L+TB group
exhibited the greatest number of attached cells among all the groups, followed by
the L+EP, L+SB and control group. The laser alone group exhibited the lowest number
of cells. Conclusions: The characteristic microstructure of the root cementum
surface after Er:YAG laser irradiation has a tendency to hinder the early
attachment of PDL cells. However, chemical and/or mechanical root conditioning
treatment may improve and increase the biocompatibility of the Er:YAG laser-treated
root cementum by removing the microstructures of the surface and/or further
exposing the collagen fibers. © 2008 Wiley-Liss, Inc.
AN - rayyan-563560718
AU - Maruyama, H.
AU - Aoki, A.
AU - Sasaki, K. M.
AU - Takasaki, A. A.
AU - Iwasaki, K.
AU - Ichinose, S.
AU - Oda, S.
AU - Ishikawa, I.
AU - Izumi, Y.
DO - 10.1002/lsm.20609
IS - 3
KW - collagen fiber
edetic acid
minocycline
sodium chloride
tetracycline
article
biocompatibility
cell adhesion
cell structure
tooth cementum
controlled study
erbium YAG laser
fibroblast
histology
human
human tissue
periodontitis
priority journal
surface property
thickness
DElight
LA - English
PY - 2008
SN - ["0196-8092", "1096-9101"]
SP - 211-222
ST - The effect of chemical and/or mechanical conditioning on the Er:YAG laser-
treated root cementum: Analysis of surface morphology and periodontal ligament
fibroblast attachment
TI - The effect of chemical and/or mechanical conditioning on the Er:YAG laser-
treated root cementum: Analysis of surface morphology and periodontal ligament
fibroblast attachment
VL - 40
ID - 14092
ER -
TY - JOUR
AB - Natural polymers, particularly polysaccharide, have been used as drug
delivery systems for a variety of therapeutic agents such as peptides, proteins,
vaccines, DNA, and drugs for parenteral and non-parenteral administration.
Chitosan, the second most abundant naturally occurring polysaccharide after
cellulose, is a biocompatible and biodegradable mucoadhesive polymer that is
extensively used in the preparation of nanoparticles (NPs). Chitosan NPs loaded
with drugs were found to be stable, permeable and bioactive. In this review, the
importance of chitosan and its derivatives in drug delivery is illustrated,
different methods of preparation of chitosan and chitosan derivatives NPs and their
phys-io-chemical properties are addressed. Moreover, the desirable characteristics
of successful NPs based drug delivery systems, as well as the pharmaceutical
applications of these NPs are also clearly ex-plored.
AN - rayyan-563560150
AU - Matalqah, S. M.
AU - Aiedeh, K.
AU - Mhaidat, N. M.
AU - Alzoubi, K. H.
AU - Bustanji, Y.
AU - Hamad, I.
DO - 10.2174/1389450121666200711172536
IS - 15
KW - nebulizer
amoxicillin
amphotericin B
attapulgite
calcium phosphate
carvacrol
cefazolin
cellulose
chitosan
chitosan derivative
cinnamaldehyde
ciprofloxacin
cisplatin
corticosteroid
curcumin
cyclosporine
daptomycin
daunorubicin
dexamethasone
dextran
diclofenac
docetaxel
doxorubicin
doxycycline
felodipine
ferulic acid
genipin
hepatitis B surface antigen
hyaluronic acid
hydrogel
indometacin
iron oxide
lactoferrin
lansoprazole
liposome
macrogol
mefenamic acid
melatonin
methotrexate
metoclopramide
microsphere
mitomycin
mucin 1
nanocomposite
nanoparticle
octreotide
ofloxacin
olanzapine
oleic acid
ovalbumin
paclitaxel
pectin
polycaprolactone
polymer
polyphenol
polysaccharide
propranolol
proton pump inhibitor
rifampicin
salbutamol
saponin
somatostatin
surfactant
tamoxifen
tetanus toxoid
tetracycline
thioglycolic acid
thymol
tripolyphosphate
vaccine
vancomycin
biocompatibility
biodegradability
biodegradation
bone development
bone regeneration
cancer therapy
Crohn disease
cross linking
cytotoxicity
drug elimination
drug industry
drug release
drug solubility
drug stability
drug synthesis
drug therapy
emulsion
encapsulation
Escherichia coli
eye irritation
freeze drying
gelation
gene expression
gene therapy
glucose blood level
immunization
immunogenicity
inflammation
leishmaniasis
micelle
microemulsion
nanoencapsulation
nanofabrication
nanomedicine
nanotechnology
nebulization
nucleus pulposus
oxidative stress
particle size
periodontal pocket
polymerization
prostate cancer
pseudomembranous colitis
review
spray drying
static electricity
stomach pH
thermostability
ulcerative colitis
visceral leishmaniasis
wound healing
zeta potential
LA - English
PY - 2020
SN - ["1873-5592", "1389-4501"]
SP - 1613-1624
ST - Chitosan nanoparticles as a novel drug delivery system: A review article
T2 - Curr. Drug Targets
TI - Chitosan nanoparticles as a novel drug delivery system: A review article
VL - 21
ID - 13524
ER -
TY - JOUR
AB - Background: The main indication of the adjunctive use of local antimicrobials
lies around situations in which the outcome of non-surgical mechanical treatment
results in a limited number of residual pockets. The purpose of this investigation
was to evaluate the clinical and microbiological effects of the subgingival
application of a xanthan-based 1. 5% chlorhexidine (CHX) gel (Xan-CHX), adjunctive
to scaling and root planing (SRP) in localized periodontitis. Methods:
Periodontitis patients with four to ten residual (after conventional SRP) or
relapsing (during supportive periodontal treatment) pockets were recruited and
randomized to receive SRP plus the subgingival application of (Xan-CHX) or SRP plus
a placebo gel. Supragingival plaque, bleeding on probing (BOP), probing pocket
depth (PPD), and clinical attachment level were evaluated with a computerized probe
at baseline, and after 1, 3, and 6 months. Subgingival samples were also collected
for the microbiological analysis. Statistical analysis used ANOVA and chi-square
tests. Results: Overall, the clinical results were better in the test group, with
significant changes in BOP (between baseline and 3 months) and with a significant
increase in the proportion of shallow pockets (1-3 mm) at 6 months. These results
did not result in significant intergroup differences. The microbiological impact
was limited in both treatment groups. Conclusion: The adjunctive use of Xan-CHX may
improve, although to a limited extent, the clinical outcomes (BOP and PPD), in
chronic periodontitis patients with "residual" or "relapsing" pockets, but no
significant differences were detected between groups. No side effects, neither
clinical nor microbiological, were detected after the use of the test product.
Clinical relevance: Adjunctive use of slow-released chlorhexidine might be
considered in the management of periodontal disease and gingival inflammation to
reduce the need for periodontal surgery. © 2012 Springer-Verlag.
AN - rayyan-563560463
AU - Matesanz, P.
AU - Herrera, D.
AU - Echeverría, A.
AU - O'Connor, A.
AU - González, I.
AU - Sanz, M.
DO - 10.1007/s00784-012-0685-5
IS - 1
KW - bacterial polysaccharide
chlorhexidine
drug carrier
placebo
xanthan
adult
aged
article
bacterial load
biofilm
chemistry
comparative study
controlled study
drug effect
education
follow up
gel
gingiva bleeding
gingiva disease
gingivitis
human
methodology
microbiology
middle aged
mouth hygiene
periodontal disease
periodontal pocket
periodontitis
tooth plaque
treatment outcome
LA - English
PY - 2013
SN - ["1432-6981", "1436-3771"]
SP - 55-66
ST - A randomized clinical trial on the clinical and microbiological efficacy of a
xanthan gel with chlorhexidine for subgingival use
TI - A randomized clinical trial on the clinical and microbiological efficacy of a
xanthan gel with chlorhexidine for subgingival use
VL - 17
ID - 13837
ER -
TY - JOUR
AB - Group 2 innate lymphoid cells (ILC2s) are present in both mouse and human
mucosal and non-mucosal tissues and implicated in initiating type 2 inflammation.
ILC2s are considered to be tissue resident cells that develop in the perinatal
period and persist throughout life with minimal turning over in adulthood. However,
recent studies in animal models have shown their ability to circulate between
different organs during inflammation and their potential functions in the destined
organs, suggesting their roles in mediating multiple type 2 diseases. Here, we
review recent findings on ILC2 migration, including migration within, into and out
of tissues during inflammation.
AN - rayyan-563559863
AU - Mathä, L.
AU - Takei, F.
AU - Martinez-Gonzalez, I.
DO - 10.3389/fimmu.2022.877005
KW - Cytoplasmic Extraction Kit
DNA purification kit
ELISA kit
micro-CT scanner
spectrophotometer
TRAP staining kit
X ray system
cyclic GMP
cyclic GMP dependent protein kinase inhibitor
cytokine
guanylate cyclase
interleukin 6
KMUP 1
kt 5823
lipopolysaccharide
phosphatase
phosphodiesterase
tiletamine plus zolazepam
transcription factor NFAT
unclassified drug
xanthine derivative
alveolar bone loss
alveolar crest
animal cell
animal experiment
animal model
animal tissue
body weight
cell culture
chemoluminescence
controlled study
drug overdose
extracellular trap
histochemistry
histology
in vitro study
in vivo study
inflammation
male
MAPK signaling
microscopy
NF kB signaling
nonhuman
osteoclastogenesis
osteolysis
periodontitis
Pi3K/Akt signaling
rat
RAW 264.7 cell line
review
signal transduction
spectrophotometry
Western blotting
LA - English
PY - 2022
SN - 1664-3224
ST - Tissue Resident and Migratory Group 2 Innate Lymphoid Cells
TI - Tissue Resident and Migratory Group 2 Innate Lymphoid Cells
VL - 13
ID - 13237
ER -
TY - JOUR
AN - rayyan-563561582
AU - Mathur, I.
AU - Shruthi, S.
AU - Gandrakota, K.
AU - Nisha, K. J.
DO - 10.5005/jp-journals-10015-1839
IS - 4
PY - 2021
SP - 265-270
ST - Comparative evaluation of antifungal activity of green coffee and green tea
extract against candida albicans: An in vitro study
TI - Comparative evaluation of antifungal activity of green coffee and green tea
extract against candida albicans: An in vitro study
85111606285&doi=10.5005%2fjp-journals-10015-
1839&partnerID=40&md5=dc4b437ade4791de44b1363e38ded9e1
VL - 12
ID - 14956
ER -
TY - JOUR
AB - Objective: Arginine-specific cysteine proteases (Rgps) from Porphyromonas
gingivalis are important virulent factors of periodontal diseases. However, there
is no therapeutic drug that inhibits proinflammatory events induced by these
enzymes. In this study, we investigated proinflammatory activities of Rgps and
activated coagulation factor X (FXa) and examined the effect of DX-9065a, a new
selective inhibitor of FXa, on proinflammatory events induced by these proteinases.
Methods: Human gingival fibroblasts were stimulated with Rgps and FXa in the
presence or absence of DX-9065a, and then interleukin-6 (IL-6) and matrix
metalloproteinase-1 (MMP-1) release, their mRNA expression, and nuclear factor κB
(NF-κB) activation were assessed using an enzyme-linked immunosorbent assay
(ELISA), northern blotting, and a gel-mobility shift method, respectively. Results:
Rgps and FXa activated IL-6 and MMP-1 release in human gingival fibroblasts through
their amidolytic activities and in mitogen-activated protein kinase (MAPK) and NF-
κB dependent manners. DX-9065a inhibited FXa-induced IL-6 mRNA expression and NF-κB
activation. DX-9065a inhibited amidolytic activities of FXa and Rgps in vitro and
ex vivo. Conclusion: Rgps and FXa are potent inflammatory mediators and DX-9065a
may be a useful therapeutic drug for periodontal disease. © Blackwell Munksgaard
2006.
AN - rayyan-563560775
AU - Matsushita, K.
AU - Imamura, T.
AU - Tomikawa, M.
AU - Tancharoen, S.
AU - Tatsuyama, S.
AU - Maruyama, I.
DO - 10.1111/j.1600-0765.2005.00853.x
IS - 2
KW - 2 [4 [(1 acetimidoyl 3 pyrrolidinyl)oxy]phenyl] 3 (7 amidino 2
naphthyl)propionic acid
adhesin
anticoagulant agent
argingipain, Porphyromonas gingivalis
autacoid
blood clotting factor 10a
cysteine proteinase
interleukin 6
naphthalene derivative
propionic acid derivative
virulence factor
article
biosynthesis
cell culture
cytology
drug antagonism
drug effect
enzymology
fibroblast
gingiva
gingivitis
human
metabolism
Northern blotting
physiology
signal transduction
LA - English
PY - 2006
SN - 0022-3484
SP - 148-156
ST - DX-9065a inhibits proinflammatory events induced by gingipains and factor Xa
TI - DX-9065a inhibits proinflammatory events induced by gingipains and factor Xa
VL - 41
ID - 14149
ER -
TY - JOUR
AB - Late embryogenesis abundant (LEA) proteins are important players in the
management of responses to stressful conditions, such as drought, high salinity,
and changes in temperature. Many LEA proteins do not have defined three-dimensional
structures, so they are intrinsically disordered proteins (IDPs) and are often
highly hydrophilic. Although LEA-like sequences have been identified in bacterial
genomes, the functions of bacterial LEA proteins have been studied only recently.
Sequence analysis of outer membrane interleukin receptor I (BilRI) from the oral
pathogen Aggregatibacter actinomycetemcomitans indicated that it shared sequence
similarity with group 3/3b/4 LEA proteins. Comprehensive nuclearcgq magnetic
resonance (NMR) studies confirmed its IDP nature, and expression studies in A.
actinomycetemcomitans harboring a red fluorescence reporter protein-encoding gene
revealed that bilRI promoter expression was increased at decreased temperatures.
The amino acid backbone of BilRI did not stimulate either the production of
reactive oxygen species from human leukocytes or the production of interleukin-6
from human macrophages. Moreover, BilRI-specific IgG antibodies could not be
detected in the sera of A. actinomycetemcomitans culture-positive periodontitis
patients. Since the bilRI gene is located near genes involved in natural competence
(i.e., genes associated with the uptake of extracellular (eDNA) and its
incorporation into the genome), we also investigated the role of BilRI in these
events. Compared to wild-type cells, the ΔbilRI mutants showed a lower
transformation efficiency, which indicates either a direct or indirect role in
natural competence. In conclusion, A. actinomycetemcomitans might express BilRI,
especially outside the host, to survive under stressful conditions and improve its
transmission potential.
AN - rayyan-563560039
AU - Maula, T.
AU - Vahvelainen, N.
AU - Tossavainen, H.
AU - Koivunen, T.
AU - T. Pöllänen, M.
AU - Johansson, A.
AU - Permi, P.
AU - Ihalin, R.
DO - 10.1080/21505594.2021.1918497
IS - 1
KW - AVANCE III HD 800
CcpNmr Analysis v. 2.4.2
cell culture plate
Cellstar
Chemidoc
cryoprobe
culture medium
ELISA kit
epsilometer test
filters and membranes
glass bottle
HisTrap
imaging system
JPred4
microplate reader
spectrometer
test strip
TopSpin 3.5
tryptic soy agar
2,2' azinobis(3 ethylbenzothiazoline 6 sulfonic acid)
4 o methylphorbol 13 acetate 12 myristate
a0170
a9941
alcohol
ampicillin
antibody
benzylsulfonyl fluoride
buffer
cold shock protein
d8537
deoxyribonuclease I
DNA ligase
doxycycline
fluorescent dye
glycerol
imidazole
interleukin 6
interleukin receptor
intrinsically disordered protein
late embryogenesis abundant protein
lipoprotein
p4333
plasmid vector
protein
sodium chloride
spectinomycin
streptomycin
sucrose
tetracycline
thrombin
unclassified drug
article
biofilm
cell viability
centrifugation
colony forming unit
controlled study
drought
Escherichia coli
fetal bovine serum
Gemella haemolysans
genetic transformation
heteronuclear nuclear magnetic resonance
macrophage
peptide synthesis
periodontitis
promoter region
protein expression
salinity
sequence alignment
sequence analysis
size exclusion chromatography
temperature
THP-1 cell line
ultrasound
Etest
LA - English
PY - 2021
SN - ["2150-5608", "2150-5594"]
SP - 1239-1257
ST - Decreased temperature increases the expression of a disordered bacterial late
embryogenesis abundant (LEA) protein that enhances natural transformation
T2 - Virulence
TI - Decreased temperature increases the expression of a disordered bacterial late
embryogenesis abundant (LEA) protein that enhances natural transformation
VL - 12
ID - 13413
ER -
TY - JOUR
AB - Platelet gel biotechnology, a method which has all the components of "tissue
engineering" techniques, potentiates the already known healing process of guided
tissue regeneration procedures (GTR) by multiplying the number of molecules that
activate the healing response and by grafting in the host site various cell types,
among which stem cells. Here are reported cases of patients affected by refractory
generalized aggressive periodontitis treated with the association GTR and platelet
gel biotechnology to verify if the contribution of the gel would produce superior
results than those obtained by surgery alone which had been previously applied to
the same sites with negative results. Three patients in therapy from 4 to 11 years,
already subjected to surgery (GTR) and antibiotic therapy, were reoperated with the
adjunct of autologous platelet gel. At a distance of 15.2 months (range 11-17
months) the operated sites showed a reduction in probing pocket depth of 3.4 mm
(range 2.8-4.8 mm) and a gain in clinical attachment level of 3.1 mm (range 3-3.5
mm). The association of platelet gel biotechnology with GTR in the surgical
treatment of intrabony defects of refractory generalized aggressive periodontitis
patients seems to produce results similar to those reported for patients with
chronic adult periodontitis. The observations at 15.2 months indicate that there is
a stability over time of the results in those sites where previous surgical therapy
had shown relapse.
AN - rayyan-563560882
AU - Mauro, S.
AU - Orlando, L.
AU - Panzoni, R.
AU - Orlando, P. F.
IS - 7
collagen
growth promotor
adult
animal
article
bone regeneration
case report
bovine
evaluation study
female
gel
human
male
middle aged
osteolysis
periodontics
periodontitis
recurrent disease
secretion (process)
thrombocyte
tissue engineering
LA - English
PY - 2003
SN - 0026-4970
SP - 401-412
ST - Platelet gel biotechnology applied to regenerative surgery of intrabony
defects in patients with refractory generalized aggressive peridontitis. Case
report
T2 - Minerva Stomatol
TI - Platelet gel biotechnology applied to regenerative surgery of intrabony
defects in patients with refractory generalized aggressive peridontitis. Case
report
VL - 52
ID - 14256
ER -
TY - JOUR
AB - The aim of this clinical study was to compare the treatment outcome following
root surface conditioning using an EDTA gel preparation in conjunction with
surgical therapy with that following conventional flap surgery in periodontal
intraosseous defects. 36 patients, each of them contributing one intraosseous
defect > or =4 mm in depth participated. Defect sites had a probing pocket depth >
or =5 mm and bled on probing following hygienic treatment phase. No furcation
involvement or endodontic complications were present. In the EDTA group, 18
consecutive patients, defects were treated by root conditioning with EDTA gel for 3
minutes in combination with surgical therapy. In the control group, 18 patients,
conventional flap surgery was performed without root conditioning. Chlorhexidine
rinsings 0.2% were prescribed following surgery for 2-3 weeks with modified oral
hygiene instruction. A strict recall program was implemented including professional
prophylaxis and oral hygiene reinforcement every 4-6 weeks until 6-month re-
evaluation. Baseline probing pocket depths and defect depths of 7.1+/-1.3 mm and
6.9+/-1.6 mm in the EDTA group and 7.6+/-1.9 mm and 6.6+/-1.7 mm, respectively, in
the control group were measured. 6-month clinical results showed a significant
probing attachment level gain of 1.8+/-1.5 mm and 1.0+/-1.7 mm in the EDTA and
control groups respectively. A probing bone gain of 1.0+/-1.3 mm in the EDTA group
was measured with a non-significant gain of 0.4+/-1.2 mm in the control group.
Radiographic analysis confirmed these results. There were no statistically
significant differences in treatment outcome between the group treated by root
conditioning in combination with flap surgery and conventional flap surgery alone.
AN - rayyan-563561022
AU - Mayfield, L.
AU - Söderholm, G.
AU - Norderyd, O.
AU - Attström, R.
IS - 9
KW - chlorhexidine
edetic acid
article
comparative study
dental acid etching
drug effect
female
follow up
gel
gingiva bleeding
human
jaw
male
methodology
middle aged
mouth hygiene
osteolysis
pathology
patient education
periodontal disease
periodontitis
plastic surgery
radiography
reproducibility
tooth root
treatment outcome
LA - English
PY - 1998
SN - 0303-6979
SP - 707-714
ST - Root conditioning using EDTA gel as an adjunct to surgical therapy for the
treatment of intraosseous periodontal defects
TI - Root conditioning using EDTA gel as an adjunct to surgical therapy for the
treatment of intraosseous periodontal defects
VL - 25
ID - 14396
ER -
TY - JOUR
AN - rayyan-563562133
AU - Maze, G. I.
DO - 10.1111/j.1600-051X.1996.tb01815.x
IS - 12
PY - 1996
SP - 1133-1136
ST - Gingival fluid tetracycline release from bioerodible gels
TI - Gingival fluid tetracycline release from bioerodible gels
0030330561&doi=10.1111%2fj.1600-
051X.1996.tb01815.x&partnerID=40&md5=650d10b417cf49900a399b33c73b3784
VL - 23
ID - 15507
ER -
TY - JOUR
AB - Intracrevicular antimicrobial therapy is consistent with the site-specific
nature of periodontitis. Considerable research has focused on the use of
nonresorbable fibers. However, a bioerodible system is desirable. The purpose of
this study was to assess tetracycline release and safety following a single
application of a syringable 35% tetracycline hydrochloride in a lactic-glycolic
acid gel. 31 generally healthy adult volunteers (mean age = 59 years) were enrolled
in and completed this randomized, double-blind eight day study. 2, 6-10 mm non-
adjacent interproximal pockets that bled on pocket probing were chosen as
experimental sites in each subject. I experimental site and the surrounding
gingival crevice received small particle size tetracycline in gel while the other
site received larger particle size tetracycline in gel. Gingival crevicular fluid
(GCF) was collected prior to treatment and 15 min, 1, 2, 3, 4 and 8 days post-
treatment. GCF tetracyline concentrations were determined by agar diffusion
bioassay and GCF volume measurements. 61% and 71% of sites had > or = 100
micrograms/ml tetracycline 3 days following application of large (mean
concentration = 430 +/- 92 micrograms/ml) and small particle gels (mean
concentration = 418 +/- 70 micrograms/ml), respectively. 37% and 55% of sites had
measurable tetracycline 8 days after placement of large (mean concentration = 86
+/- 31 micrograms/ml) and small particle gels (mean concentration = 293 +/- 79
micrograms/ml), respectively. The most common adverse event was "bitter taste" (10%
of subjects). Based upon the reduction in probing depths and % of sites bleeding on
probing at 8 days relative to pretreatment, and the absence of any serious adverse
events, it is concluded that these bioerodible gels are safe, and since the
bacteriostatic range for most putative periodontopathogens is in the 2-10
micrograms/ml range, the tetracycline levels observed at days 3 and 8 likely
represent significant antimicrobial efficacy.
AN - rayyan-563561052
AU - Maze, G. I.
AU - Reinhardt, R. A.
AU - Payne, J. B.
AU - Maze, C.
AU - Baker, R. A.
AU - Bouwsma, O. J.
AU - Damani, N. C.
AU - Fitzgerald, J.
AU - Hamlin, J. C.
AU - Gerlach, R. W.
IS - 12
glycolic acid
glycolic acid derivative
lactic acid
tetracycline
adult
aged
article
bioremediation
clinical trial
controlled study
female
gel
gingivitis
human
male
middle aged
particle size
periodontitis
LA - English
PY - 1996
SN - 0303-6979
SP - 1133-1136
ST - Gingival fluid tetracycline release from bioerodible gels
TI - Gingival fluid tetracycline release from bioerodible gels
VL - 23
ID - 14426
ER -
TY - JOUR
AB - Objective: To compare the short-term performance of subgingival local
delivery of 2% minocycline gel and conventional subgingival debridement in
supportive periodontal therapy (SPT) patients. Methods: Forty adult patients having
completed active treatment for moderate to advanced chronic periodontitis were
included in a randomized, controlled, single masked maintenance care pilot study.
Sites with residual pocket probing depths ≥5 mm and bleeding on probing were
treated with either minocycline gel (minocycline-group) or scaling and root planing
only (debridement-group) at baseline, 3, 6, and 9 months. Clinical and
microbiological examinations were performed at baseline, 3, 6, 9, and 12 months.
Results: Full-mouth plaque and bleeding scores remained <10% and <20%,
respectively, for both groups throughout the study. In both groups there was a
persistent reduction in number of teeth and sites with probing pocket depths ≥5 mm
(p<0.05) with no significant differences between the groups. The prevalence of
Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Actinobacillus
actinomycetemcomitans, Prevotella intermedia, and Prevotella nigrescens, remained
at levels ≤105 in the majority of patients and sites in both groups. Conclusion:
This pilot study failed to show a difference between local delivery of 2%
minocycline gel as mono-therapy and traditional subgingival debridement in patients
on SPT. © Blackwell Munksgaard 2006.
AN - rayyan-563560776
AU - McColl, E.
AU - Patel, K.
AU - Dahlen, G.
AU - Tonetti, M.
AU - Graziani, F.
AU - Suvan, J.
AU - Laurell, L.
DO - 10.1111/j.1600-051X.2005.00879.x
IS - 2
minocycline
adult
article
bacterial count
Bacteroides
clinical trial
comparative study
controlled study
drug effect
female
follow up
gel
gingiva bleeding
human
male
microbiology
middle aged
periodontitis
pilot study
Treponema denticola
LA - English
PY - 2006
SN - ["0303-6979", "1600-051X"]
SP - 141-150
ST - Supportive periodontal therapy using mechanical instrumentation or 2%
minocycline gel: A 12 month randomized, controlled, single masked pilot study
TI - Supportive periodontal therapy using mechanical instrumentation or 2%
minocycline gel: A 12 month randomized, controlled, single masked pilot study
VL - 33
ID - 14150
ER -
TY - JOUR
AB - Cidofovir is a broad-spectrum antiviral agent with activity against several
DNA viruses. An application to approve the use of topical cidofovir for acyclovir-
resistant herpes virus infection was denied by the US Food and Drug Administration
owing to the lack of phase III clinical trial data. The manufacturer stated that,
as of 1997, no further controlled studies were planned or in progress to evaluate
topical cidofovir in herpes simplex infections. It is unknown whether there are
plans to conduct controlled studies of topical cidofovir for HPV or MVC infections.
However, numerous case reports and published studies describe successful use of
topical cidofovir to treat resistant and severe forms of viral infections such as
molluscum contagiosum, condylomata acuminata, verruca vulgaris, herpes simplex
virus infection, genital warts, and gingival infection with human papillomavirus.
Because of the mutagenic properties of cidofovir, compounding the preparation is
considered hazardous. Since most retail pharmacies do not have the safely equipment
necessary to compound hazardous preparations, a compounding pharmacist can play a
vital role in preparing topical cidofovir cream or gel.
AN - rayyan-563560763
AU - McElhiney, L. F.
IS - 5
KW - aciclovir
alpha interferon
cidofovir
dermovan
DNA polymerase
foscarnet
ganciclovir
imiquimod
lanolin alcohol
placebo
podophyllotoxin
propylene glycol
retinoic acid
thymidine kinase
trichloroacetic acid
congenital malformation
malignant neoplasm
cauterization
clinical trial
condyloma
condyloma acuminatum
drug cost
drug efficacy
drug excretion
drug formulation
drug half life
drug mechanism
drug metabolism
drug tolerability
gingivitis
human
laser coagulation
molluscum contagiosum
mucosal erosion
nephrotoxicity
neutropenia
nonhuman
oligospermia
patient monitoring
retinitis
review
side effect
skin defect
skin redness
treatment outcome
wart
virus infection
vistide
LA - English
PY - 2006
SN - 1092-4221
SP - 324-328
ST - Topical cidofovir for treatment of resistant viral infections
TI - Topical cidofovir for treatment of resistant viral infections
VL - 10
ID - 14137
ER -
TY - JOUR
AB - Oral microbes represent one of the most well studied microbial communities
owing to the fact that they are a fundamental part of human development influencing
health and disease, an easily accessible human microbiome, a highly structured and
remarkably resilient biofilm as well as a model of bacteria-bacteria and bacteria-
host interactions. In the last 80 years since oral plaque was first characterized
for its functionally stable physiological properties such as the highly repeatable
rapid pH decrease upon carbohydrate addition and subsequent recovery phase, the
fundamental approaches to study the oral microbiome have cycled back and forth
between community level investigations and characterizing individual model
isolates. Since that time, many individual species have been well characterized and
the development of the early plaque community, which involves many cell-cell
binding interactions, has been carefully described. With high throughput sequencing
enabling the enormous diversity of the oral cavity to be realized, a number of new
challenges to progress were revealed. The large number of uncultivated oral
species, the high interpersonal variability of taxonomic carriage and the
possibility of multiple pathways to dysbiosis pose as major hurdles to obtain a
systems level understanding from the community to the gene level. It is now
possible however to start connecting the insights gained from single species with
community wide approaches. This review will discuss some of the recent insights
into the oral microbiome at a fundamental level, existing knowledge gaps, as well
as challenges that have surfaced and the approaches to address them.
AN - rayyan-563560459
AU - McLean, J. S.
DO - 10.3389/fcimb.2014.00098
KW - acetic acid
butyric acid
formic acid
glucose
lactic acid
propionic acid
pyruvic acid
RNA 16S
bacterial genome
bacterial metabolism
bacterial virulence
biofilm
commensal
dental caries
DNA sequence
gene expression
human
metagenomics
microbial community
microbial diversity
microbial genome
microbiome
mouth cavity
mouth flora
nonhuman
periodontal disease
pH
phylogeny
review
tooth disease
tooth plaque
transcriptomics
LA - English
PY - 2014
SN - 2235-2988
ST - Advancements toward a systems level understanding of the human oral
microbiome
TI - Advancements toward a systems level understanding of the human oral
microbiome
VL - 4
ID - 13833
ER -
TY - JOUR
AB - A number of delivery systems have been investigated for administration of
antibacterial agents in the treatment of plaque-initiated periodontal disease.
These include prolonged release intrapocket devices which are inserted at diseased
sites. An effective antibacterial concentration is maintained if drug lost by
elimination processes is replaced. Bioassays or sensitive HPLC assays may be used
to monitor drug concentrations in the gingival crevicular fluid and allow
estimation of the duration of effective release. Non-degradable and degradable
systems have been developed, and although improvements in clinical and
microbiological parameters are reported with both these systems, advantages have
been identified with the degradable systems. Importantly, depleted degradable
devices do not require removal at the end of treatment, but repeated administration
is generally required, as these systems mostly produce effective drug
concentrations for short periods. To improve this method of drug administration the
aims and optimal duration of treatment need to be further clarified so that
development of delivery system can occur through modification of the device's
release and degradation characteristics.
AN - rayyan-563562322
AU - Medlicott, N. J.
AU - Rathbone, M. J.
AU - Tucker, I. G.
AU - Holborow, D. W.
DO - 10.1016/0169-409X(94)90033-7
IS - 1
PY - 1994
SN - ["0169-409X", "1872-8294"]
SP - 181-203
ST - DELIVERY SYSTEMS FOR THE ADMINISTRATION OF DRUGS TO THE PERIODONTAL POCKET
T2 - ADVANCED DRUG DELIVERY REVIEWS
TI - DELIVERY SYSTEMS FOR THE ADMINISTRATION OF DRUGS TO THE PERIODONTAL POCKET
VL - 13
Y2 - 1
ID - 15696
ER -
TY - JOUR
AB - Periodontitis is a chronic bacterial infection, and its effective treatment
is dependent on the retention of antibiotics of effective concentrations at the
periodontal pockets. In this study, a solution–gel based inverse lyotropic liquid
crystalline (LLC) system was explored to deliver metronidazole to the periodontal
pockets for local treatment of periodontitis. It was found that the metronidazole-
loaded LLC precursor spontaneously transformed into gel in the presence of water in
the oral cavity. The low viscosity of the precursor would allow its penetration to
the rather difficult to reach infection sites, while the adhesiveness and
crystalline nanostructures (inverse bicontinuous cubic Pn3m phase and inverse
hexagonal phase) of the formed gel would permit its firm adhesion to the
periodontal pockets. The LLC system provided sustained drug release over one week
in vitro. Results from in vivo study using a rabbit periodontitis model showed that
the LLC system was able to maintain the metronidazole concentrations in the
periodontal pockets above the minimum inhibition concentration for over 10 days
without detectable drug concentration in the blood. Owing to the spontaneous
solution–gel transition in the periodontal pockets and unique liquid crystalline
nanostructures, the LLC in situ gel provided effective treatment of periodontitis
for a prolonged period of time with reduced systematic side effects, compared to
metronidazole suspension which was effective for 24 h with detectable metronidazole
concentrations in the blood after 6 h.
AN - rayyan-563560323
AU - Mei, L.
AU - Huang, X.
AU - Xie, Y.
AU - Chen, J.
AU - Huang, Y.
AU - Wang, B.
AU - Wang, H.
AU - Pan, X.
AU - Wu, C.
DO - 10.1080/10717544.2017.1359703
IS - 1
KW - metronidazole
nanomaterial
adhesion
animal experiment
animal model
area under the curve
article
controlled study
drug absorption
drug blood level
drug half life
effective concentration
gelation
gingiva
in vitro study
in vivo study
inhibitory concentration
liquid crystal
local therapy
lyotropic liquid crystalline
New Zealand rabbit
nonhuman
periodontal pocket
phase transition
priority journal
viscoelasticity
LA - English
PY - 2017
SN - ["1521-0464", "1071-7544"]
SP - 1148-1158
ST - An injectable in situ gel with cubic and hexagonal nanostructures for local
T2 - Drug Deliv.
TI - An injectable in situ gel with cubic and hexagonal nanostructures for local
VL - 24
ID - 13697
ER -
TY - JOUR
AB - A presença da placa bacteriana representa o principal fator etiológico
envolvido na iniciação e progressão da doença periodontal inflamatória. O
tratamento instituído para esta patologia baseia-se essencialmente na eliminação
dos patógenos periodontais, através do debridamento mecânico. Entretanto, nem
sempre a raspagem e alisamento radicular promovem resultados clínicos
satisfatórios, guiando o profissional a buscar meios alternativos para este
tratamento. Neste sentido surgiram os antimicrobianos de ação local, sendo
atualmente empregados: gel de metronidazol, chip de clorexidina, fibra de
tetraciclina, esferas de minociclina e gel de doxiciclina Diversos relatos na
literatura sustentam o emprego desses dispositivos e comprovam a sua eficácia
clínica.No entanto, aspectos como custo e acessibilidade vêm sendo discutidos a fim
de avaliar a real aplicabilidade.O objetivo desta revisão de literatura é fazer uma
abordagem crítica a respeito da utilização de antimicrobianos locais no tratamento
da doença periodontal enfatizando as suas indicações, vantagens, desvantagens,
custo, viabilidade clínica e eficácia terapêutica.
AN - rayyan-563559885
AU - Meira, Ana LuísaTeixeira
AU - Todescan, Sylvia Maria Correia
AU - Azoubel, Eduardo
AU - Bittencourt, Sandro
AU - Azoubel, Maria Cecília Fonsêca
IS - 1
LA - pt
PY - 2007
SN - 0103-9393
SP - 92-98
ST - Uso de antimicrobianos locais em periodontia: uma abordagem crítica
T2 - Periodontia
TI - Uso de antimicrobianos locais em periodontia: uma abordagem crítica
UR - https://pesquisa.bvsalud.org/portal/resource/pt/lil-518829
VL - 17
Y2 - 3
ID - 13259
ER -
TY - JOUR
AB - Objective: This randomized clinical trial evaluated the efficacy and safety
of a blue-covarine whitening toothpaste on tooth bleaching. Subjects and methods:
Seventy-five subjects with shade mean C1 or darker were randomized into three
groups (n = 25): CT-conventional toothpaste, WT-whitening toothpaste, and CP10-10%
carbamide peroxide. Subjects from CT and WT brushed their teeth twice/day for 2
weeks. CP10 used bleaching gel for 4 hours/night for 2 weeks. Tooth shade and
CIELab parameters were measured at baseline, after the first application, 2- and 4-
week. ΔE*ab and ΔE00 were calculated. Subjects' perception about tooth color
appearance, tooth sensitivity (TS), and gingival irritation (GI) were also
assessed. Results: At all evaluation periods, it was not observed differences
between WT and CT considering tooth shade (P > 0.7) or CIELab parameters (P > 0.3).
At 2- and 4-week, ΔE*ab and ΔE00 were higher for CP10 than WT or CT (P = 0.001). WT
and CT reported major dissatisfaction with tooth color appearance than CP10 (P =
0.001). At 1- and 2-week, WT experienced GI and TS similar to CT, both lower than
CP10 (P < 0.01). Conclusion: There were no significant differences in the whitening
efficacy between whitening and conventional toothpastes. Neither of the dentifrices
was as effective as at-home bleaching. Clinical significance: The silica-based
toothpaste containing blue covarine evaluated in this study did not give
significant tooth whitening benefits over 2 weeks of use.
AN - rayyan-563560011
AU - Meireles, S. S.
AU - de Sousa, J. P.
AU - Lins, R. B. E.
AU - Sampaio, F. C.
DO - 10.1111/jerd.12605
IS - 2
KW - ClinicalTrials.gov02741427
spectrophotometer
Vita Easyshade
blue covarine
carbamide peroxide
pumice
toothpaste
unclassified drug
adult
anamnesis
article
canine tooth
controlled study
dental procedure
dental prophylaxis
drug efficacy
female
gingiva
gingivitis
human
male
mouth hygiene
perception
plaque index
tooth brushing
tooth color
tooth discoloration
visual analog scale
LA - English
PY - 2021
SN - ["1708-8240", "1496-4155"]
SP - 341-350
ST - Efficacy of whitening toothpaste containing blue covarine: A double-blind
controlled randomized clinical trial
TI - Efficacy of whitening toothpaste containing blue covarine: A double-blind
controlled randomized clinical trial
VL - 33
ID - 13385
ER -
TY - JOUR
AB - Objective: This randomized clinical trial evaluated the effectiveness and
tooth sensitivity (TS) of 37.5% hydrogen peroxide (37.5HP) in-office bleaching with
reduced protocol. Materials and methods: Forty participants with shade mean C2 or
darker for the six maxillary anterior teeth were randomly allocated into two
treatment groups (n = 20): two (37.5HP2) or three (37.5HP3) 8 min
applications/clinical session. Three clinical sessions were performed with a 1 week
interval. Color evaluations were done with a spectrophotometer at baseline and 1
week post-bleaching. TS was measured during and up to 48 h after bleaching using a
five-point numeric rating scale. Color change was evaluated by Student's t-test for
independent samples. The absolute risk and intensity of TS were analyzed by
Fisher's and Mann–Whitney/Friedman tests (p < 0.05). Result: Both treatment groups
resulted in a significant tooth whitening 1 week post-bleaching (p < 0.001). There
were no significant differences between 37.5HP2 and 37.5HP3 for ΔE*ab, ΔE00 and
∆WID. Also, there were not differences between groups regarding high absolute risk
(p = 1.0) and low intensity of TS at all time assessments (p > 0.7). Conclusions:
The in-office bleaching with two 37.5% HP applications produced the same whitening
degree, risk and intensity of TS to that performed with three gel applications.
Clinical significance: Clinicians should opt to use a neutral 37.5% HP in-office
bleaching gel for two 8 min applications/clinical session because produces the same
whitening effectiveness, risk and low intensity of TS as the protocol proposed by
manufacturer (three 8 min applications).
AN - rayyan-563559978
AU - Meireles, S. S.
AU - Santos, M. E.
AU - Lustosa, Í M. C.
AU - Leite, E. L. L.
DO - 10.1111/jerd.12744
IS - 5
KW - spectrophotometer
chlorhexidine
hydrogen peroxide
tetracycline
adult
article
blindness
clinical article
female
human
male
malocclusion
mouth hygiene
pain intensity
periodontal disease
protein degradation
signal noise ratio
signal transduction
tooth brushing
tooth discoloration
young adult
LA - English
PY - 2021
SN - ["1708-8240", "1496-4155"]
SP - 824-831
ST - Effects of a reduced in-office bleaching protocol with 37.5% hydrogen
peroxide on effectiveness and tooth sensitivity: A double-blind randomized clinical
trial
TI - Effects of a reduced in-office bleaching protocol with 37.5% hydrogen
peroxide on effectiveness and tooth sensitivity: A double-blind randomized clinical
trial
VL - 33
ID - 13352
ER -
TY - JOUR
AB - Nowadays, the drug delivery systems are considered as a strategy to decrease
the side effects and increase the therapeutic effect of antibiotics in
osteomyelitis. In the present study, biocompatibility, cytotoxicity, antimicrobial,
and biofilm inhibitory effects of gentamicin-loaded CaCO3 against Pseudomonas
aeruginosa were determined. The antimicrobial and biofilm effects of gentamicin-
loaded CaCO3 were studied against P. aeruginosa by minimum inhibitory (MIC) and
minimum biofilm inhibitory concentrations (BIC), respectively. Biocompatibility of
gentamicin-loaded CaCO3 was examined by the effect on the hemolysis rate of human
red blood cells (HRBCs) and erythrocyte sedimentation rate (ESR). The SDS-PAGE
assay was performed to show the protein-gentamicin-loaded CaCO3 interaction by
human blood plasma. Cytotoxicity of the gentamicin-loaded CaCO3 was determined by
the MTT assay (hBM-MSC cell viability). In the current study, the gentamicin-loaded
CaCO3 has shown antibacterial and antibiofilm effects against all isolates at
different concentrations higher than MICs and BICs of gentamicin. Gentamicin-loaded
CaCO3 has no significant effect on HRBCs hemolysis and ESR. A low interaction of
gentamicin-loaded CaCO3 was observed with apolipoprotein A1 with a molecular weight
of 28 kDa than albumin in HBP (66.5 kDa). The viability of hBM-MSC cells treated
with serial concentrations of gentamicin-loaded CaCO3 was 95–100%. According to
these results, gentamicin-loaded CaCO3 display the favorable biocompatibility
characterization, cytotoxicity; and antibacterial and biofilm activities and can be
a promising option for chronic and untreatable osteomyelitis.
AN - rayyan-563560165
AU - Memar, M. Y.
AU - Adibkia, K.
AU - Farajnia, S.
AU - Kafil, H. S.
AU - Maleki-Diza, S.
AU - Ghotaslou, R.
DO - 10.1016/j.jddst.2019.101307
KW - albumin
apolipoprotein A1
calcium carbonate nanoparticle
gentamicin
nanoparticle
unclassified drug
article
bacterium isolate
biocompatibility
cell viability
controlled study
drug cytotoxicity
erythrocyte
erythrocyte sedimentation rate
female
hemolysis
hemolysis assay
human
human cell
in vitro study
molecular weight
MTT assay
nonhuman
osteomyelitis
protein interaction
LA - English
PY - 2019
SN - 1773-2247
ST - Biocompatibility, cytotoxicity and antimicrobial effects of gentamicin-loaded
CaCO3 as a drug delivery to osteomyelitis
TI - Biocompatibility, cytotoxicity and antimicrobial effects of gentamicin-loaded
CaCO3 as a drug delivery to osteomyelitis
VL - 54
ID - 13539
ER -
TY - JOUR
AB - The present study aimed to prepare and characterize vancomycin-loaded
mesoporous silica nanoparticles (Van-MSNs) to detect inhibitory effects on the
planktonic and biofilm forms of methicillin-resistant Staphylococcus aureus (MRSA)
isolates, and study the biocompatibility and toxicity of Van-MSNs in vitro as well
as antibacterial activity of Van-MSNs against Gram-negative bacteria. The
inhibitory effects of Van-MSNs were investigated on MRSA using the determination of
minimum inhibitory (MIC) and minimum biofilm-inhibitory concentrations (MBIC) as
well as the effect on bacterial attachment. Biocompatibility was studied by
examining the effect of Van-MSNs on the lysis and sedimentation rate of red blood
cells (RBC). The interaction of Van-MSNs with human blood plasma was detected by
the SDS-PAGE approach. The cytotoxic effect of the Van-MSNs on human bone marrow
mesenchymal stem cells (hBM-MSCs) was evaluated by the MTT assay. The antibacterial
effects of vancomycin and Van-MSNs on Gram-negative bacteria were also investigated
using MIC determination using the broth microdilution method. Furthermore, bacteria
outer membrane (OM) permeabilization was determined. Van-MSNs showed inhibitory
effects on planktonic and biofilm forms of bacteria on all isolates at levels lower
than MICs and MBICs of free vancomycin, but the antibiofilm effect of Van-MSNs was
not significant. However, Van-MSNs did not affect bacterial attachment to surfaces.
Van-loaded MSNs did not show a considerable effect on the lysis and sedimentation
of RBC. A low interaction of Van-MSNs was detected with albumin (66.5 kDa). The
hBM-MSCs viability in exposure to different levels of Van-MSNs was 91–100%. MICs of
≥ 128 µg/mL were observed for vancomycin against all Gram-negative bacteria. In
contrast, Van-MSNs exhibited modest antibacterial activity inhibiting the tested
Gram-negative bacterial strains, at concentrations of ≤ 16 µg/mL. Van-MSNs
increased the OM permeability of bacteria that can increase the antimicrobial
effect of vancomycin. According to our findings, Van-loaded MSNs have low
cytotoxicity, desirable biocompatibility, and antibacterial effects and can be an
option for the battle against planktonic MRSA.
AN - rayyan-563559724
AU - Memar, M. Y.
AU - Yekani, M.
AU - Farajnia, S.
AU - Ghadiri Moghaddam, F.
AU - Nabizadeh, E.
AU - Sharifi, S.
DO - 10.1007/s00203-023-03447-6
IS - 4
KW - ciprofloxacin
clindamycin
erythromycin
gentamicin
linezolid
rifampicin
vancomycin
Acinetobacter baumannii
article
biocompatibility
biofilm inhibitory concentration
broth dilution
Brunauer Emmett Teller method
controlled study
drug release
erythrocyte
Escherichia coli
human
in vitro study
minimum biofilm inhibitory concentration
MTT assay
particle size
sedimentation rate
surface charge
X ray diffraction
LA - English
PY - 2023
SN - ["1432-072X", "0302-8933"]
ST - Antibacterial and biofilm-inhibitory effects of vancomycin-loaded mesoporous
silica nanoparticles on methicillin-resistant staphylococcus aureus and gram-
negative bacteria
T2 - Arch. Microbiol.
TI - Antibacterial and biofilm-inhibitory effects of vancomycin-loaded mesoporous
silica nanoparticles on methicillin-resistant staphylococcus aureus and gram-
negative bacteria
VL - 205
ID - 13098
ER -
TY - JOUR
AB - With the advancement of biomedical research into antimicrobial treatments for
various diseases, the source and delivery of antibiotics have attracted attention.
In periodontal diseases, antibiotics are integral in positive treatment outcomes;
however, the use of antibiotics is with caution as the potential for the emergence
of resistant strains is of concern. Over the years, conventional routes of drug
administration have been proven to be effective for the treatment of PD, yet the
problem of antibiotic resistance to conventional therapies continues to remain a
setback in future treatments. Hydrogels fabricated from natural and synthetic
polymers have been extensively applied in biomedical sciences for the delivery of
potent biological compounds. These polymeric materials either have intrinsic
antibacterial properties or serve as good carriers for the delivery of
antibacterial agents. The biocompatibility, low toxicity and biodegradability of
some hydrogels have favoured their consideration as prospective carriers for
antibacterial drug delivery in PD. This article reviews PD and its antibiotic
treatment options, the role of bacteria in PD and the potential of hydrogels as
antibacterial agents and for antibiotic drug delivery in PD. Finally, potential
challenges and future directions of hydrogels for use in PD treatment and diagnosis
are also highlighted.
AN - rayyan-563559707
AU - Mensah, A.
AU - Rodgers, A. M.
AU - Larrañeta, E.
AU - McMullan, L.
AU - Tambuwala, M.
AU - Callan, J. F.
AU - Courtenay, A. J.
IS - 6
KW - amoxicillin
antibiotic agent
antiinfective agent
azithromycin
chalcone
chlorhexidine
ciprofloxacin
clindamycin
gentamicin
graphene
hydrogel
liposome
minocycline
oxytetracycline
polyvinyl alcohol
tetracycline
antibiotic therapy
biocompatibility
biodegradability
biological activity
bioprinting
cross linking
debridement
drug diffusion
drug release
encapsulation
endophthalmitis
human
immune response
medical research
mouth hygiene
oxidative stress
periodontal disease
periodontitis
review
sepsis
tissue engineering
tissue regeneration
Treponema denticola
wound healing
LA - English
PY - 2023
SN - 2079-6382
ST - Treatment of Periodontal Infections, the Possible Role of Hydrogels as
Antibiotic Drug-Delivery Systems
T2 - Antibiotics
TI - Treatment of Periodontal Infections, the Possible Role of Hydrogels as
VL - 12
ID - 13081
ER -
TY - JOUR
AB - With the advancement of biomedical research into antimicrobial treatments for
various diseases, the source and delivery of antibiotics have attracted attention.
In periodontal diseases, antibiotics are integral in positive treatment outcomes;
however, the use of antibiotics is with caution as the potential for the emergence
of resistant strains is of concern. Over the years, conventional routes of drug
administration have been proven to be effective for the treatment of PD, yet the
problem of antibiotic resistance to conventional therapies continues to remain a
setback in future treatments. Hydrogels fabricated from natural and synthetic
polymers have been extensively applied in biomedical sciences for the delivery of
potent biological compounds. These polymeric materials either have intrinsic
antibacterial properties or serve as good carriers for the delivery of
antibacterial agents. The biocompatibility, low toxicity and biodegradability of
some hydrogels have favoured their consideration as prospective carriers for
antibacterial drug delivery in PD. This article reviews PD and its antibiotic
treatment options, the role of bacteria in PD and the potential of hydrogels as
antibacterial agents and for antibiotic drug delivery in PD. Finally, potential
challenges and future directions of hydrogels for use in PD treatment and diagnosis
are also highlighted.
AN - rayyan-563562218
AU - Mensah, A.
AU - Rodgers, A. M.
AU - Larraneta, E.
AU - McMullan, L.
AU - Tambuwala, M.
AU - Callan, J. F.
AU - Courtenay, A. J.
IS - 6
PY - 2023
SN - 2079-6382
ST - Treatment of Periodontal Infections, the Possible Role of Hydrogels as
T2 - ANTIBIOTICS-BASEL
TI - Treatment of Periodontal Infections, the Possible Role of Hydrogels as
VL - 12
Y2 - 6
ID - 15592
ER -
TY - JOUR
AB - Licorice, the name given to the roots and stolons of Glycyrrhiza species, has
been used since ancient times as a traditional herbal remedy. Licorice contains
several classes of secondary metabolites with which numerous human health benefits
have been associated. Recent research suggests that licorice and its bioactive
ingredients such as glycyrrhizin, glabridin, licochalcone A, licoricidin, and
licorisoflavan A possess potential beneficial effects in oral diseases. This paper
reviews the effects of licorice and licorice constituents on both the oral
microbial pathogens and the host immune response involved in common ora-dental
diseases (dental caries, periodontitis, candidiasis, and recurrent aphthous
ulcers). It also summarizes results of clinical trials that investigated the
potential beneficial effects of licorice and its constituents for
preventing/treating oro-dental diseases. © 2011 John Wiley & Sons A/S.
AN - rayyan-563560568
AU - Messier, C.
AU - Epifano, F.
AU - Genovese, S.
AU - Grenier, D.
DO - 10.1111/j.1601-0825.2011.01842.x
IS - 1
KW - benzofuran derivative
chalcone derivative
coumarin derivative
flavone derivative
flavonoid
gancaonin G
glabridin
glabrol
glycyrol
glycyrrhetinic acid
Glycyrrhiza extract
glycyrrhizic acid
glycyrrhizic acid derivative
glycyrrhizol A
hydrocortisone
isoflavonoid
isoliquiritigenin
licoagroaurone
licochalcone A
licocoumarone
licoricidin
licorisoflavan A
liquiritigenin
paracetamol
phenol derivative
pterocarpan derivative
saponin
stilbene derivative
unclassified drug
unindexed drug
warfarin
aphthous stomatitis
bacterial virulence
biofilm
dental caries
drug efficacy
drug megadose
drug metabolism
drug safety
drug solubility
drug tolerability
gingivitis
Glycyrrhiza
human
hydrogel
hypermineralocorticoid like effect
hypertension
hypokalemia
immune response
in vitro study
in vivo study
medicinal plant
Medline
mouth flora
nonhuman
periodontal disease
periodontitis
phytochemistry
priority journal
recurrent disease
review
saliva
thrush
tooth disease
tooth plaque
LA - English
PY - 2012
SN - ["1354-523X", "1601-0825"]
SP - 32-39
ST - Licorice and its potential beneficial effects in common oro-dental diseases
T2 - Oral Dis.
TI - Licorice and its potential beneficial effects in common oro-dental diseases
VL - 18
ID - 13942
ER -
TY - JOUR
AB - The present study developed an experimental metronidazole-based gel and
evaluated its efficacy for the adjuvant treatment of chronic periodontitis. Sixteen
patients were randomly allocated into two groups of eight subjects according to the
following proposed treatments: (1) scaling and root planing (active control) or (2)
scaling and root planing and direct periodontal intrapocket application of 15%
metronidazole-based gel in two sites (≥5 mm in depth) (experimental group).
Potential changes in the subgingival microbiota were assessed using a DNA
Checkerboard method at three proposed times: baseline and following 7 or 30 days of
drug administration. High-performance liquid chromatography (HPLC) monitored
metronidazole concentrations in the crevicular fluid during treatment. The
metronidazole experimental group presented lower bacterial counts than the control
group at the three evaluated times (p<0.01 for baseline, p<0.001 for 7 or 30 days)
when the target species were analyzed as a pool of bacteria. Samples revealed
significantly lower counts 7 days after drug administration compared with baseline
or after 30 days (p<0.05). HPLC analysis detected gel 1 h after application. The
metronidazolebased gel significantly decreased the total bacterial count at the
three evaluated times. Periodontopathogenic species were not different after gel
administration. © Springer-Verlag 2011.
AN - rayyan-563560542
AU - Miani, P. K.
AU - Do Nascimento, C.
AU - Sato, S.
AU - Filho, A. V.
AU - Da Fonseca, M. J. V.
AU - Pedrazzi, V.
DO - 10.1007/s10096-011-1484-7
IS - 7
KW - metronidazole
poloxamer
adult
aged
article
bacterial cell
bacterial count
clinical article
controlled study
drug efficacy
drug formulation
female
gel
human
in vivo study
male
mouth flora
outcome assessment
priority journal
species differentiation
LA - English
PY - 2012
SN - ["0934-9723", "1435-4373"]
SP - 1611-1618
ST - In vivo evaluation of a metronidazole-containing gel for the adjuvant
treatment of chronic periodontitis: Preliminary results
T2 - Eur. J. Clin. Microbiol. Infect. Dis.
TI - In vivo evaluation of a metronidazole-containing gel for the adjuvant
treatment of chronic periodontitis: Preliminary results
VL - 31
ID - 13916
ER -
TY - JOUR
AB - Hydrogels have been widely applied to the fabrication of tissue engineering
scaffolds via three-dimensional (3D) bioprinting because of their extracellular
matrix-like properties, capacity for living cell encapsulation, and shapeable
customization depending on the defect shape. However, the current hydrogel
scaffolds show limited regeneration activity, especially in the application of
periodontal tissue regeneration. In this study, we attempted to develop a novel
multi-component hydrogel that possesses good biological activity, can wrap living
cells for 3D bioprinting and can regenerate periodontal soft and hard tissue. The
multi-component hydrogel consisted of gelatin methacryloyl (GelMA), sodium alginate
(SA) and bioactive glass microsphere (BGM), which was first processed into hydrogel
scaffolds by cell-free 3D printing to evaluate its printability and in vitro
biological performances. The cell-free 3D-printed scaffolds showed uniform porous
structures and good swelling capability. The BGM-loaded scaffold exhibited good
biocompatibility, enhanced osteogenic differentiation, apatite formation abilities
and desired mechanical strength. The composite hydrogel was further applied as a
bio-ink to load with mouse bone marrow mesenchymal stem cells (mBMSCs) and growth
factors (BMP2 and PDGF) for the fabrication of a scaffold for periodontal tissue
regeneration. The cell wrapped in the hydrogel still maintained good cellular
vitality after 3D bioprinting and showed enhanced osteogenic differentiation and
soft tissue repair capabilities in BMP2- and PDGF-loaded scaffolds. It was noted
that after transplantation of the cell- and growth factor-laden scaffolds in Beagle
dog periodontal defects, significant regeneration of gingival tissue, periodontal
ligament, and alveolar bone was detected. Importantly, a reconstructed periodontal
structure was established in the treatment group eight weeks post-transplantation
of the scaffolds containing the cell and growth factors. In conclusion, we
developed a bioactive composite bio-ink for the fabrication of scaffolds applicable
for the reconstruction and regeneration of periodontal tissue defects.
AN - rayyan-563559696
AU - Miao, G.
AU - Liang, L.
AU - Li, W.
AU - Ma, C.
AU - Pan, Y.
AU - Zhao, H.
AU - Zhang, Q.
AU - Xiao, Y.
AU - Yang, X.
DO - 10.3390/biom13071062
IS - 7
composite material
confocal microscope
imaging software
microscope
spectrophotometer
tissue scaffold
alginic acid
apatite
collagen type 1
dexamethasone
gelatin
gentamicin
growth factor
hydrogel
microsphere
molecular scaffold
noradrenalin
osteocalcin
osteopontin
alveolar bone
angiogenesis
animal cell
animal experiment
animal tissue
article
beagle
biocompatibility
biological activity
bioprinting
bone defect
bone development
bone tissue
cell culture
cell encapsulation
cell growth
cell proliferation
cell proliferation assay
cell viability
controlled study
debridement
dog
encapsulation
gingiva bleeding
gingival tissue
histopathology
housekeeping gene
in vitro study
nonhuman
osseointegration
osteoblast
periodontics
physical chemistry
porosity
pseudopodium
soft tissue
swelling
tissue engineering
tissue regeneration
tissue repair
water absorption
X ray diffraction
LA - English
PY - 2023
SN - 2218-273X
ST - 3D Bioprinting of a Bioactive Composite Scaffold for Cell Delivery in
Periodontal Tissue Regeneration
T2 - Biomolecules
TI - 3D Bioprinting of a Bioactive Composite Scaffold for Cell Delivery in
Periodontal Tissue Regeneration
VL - 13
ID - 13070
ER -
TY - JOUR
AB - An anti-plaque gel, containing no pharmaceutical chemicals, alcohol, xylitol,
artificial or synthetic ingredients, with clinically proven plaque reducing
efficacy was evaluated as a toothpaste together with toothbrushing The study was
designed to achieve an optimal level of homecare and an effective degree of plaque
reduction following professional periodontal therapy to aid in the management of
periodontal disease. The study consisted of two blinded trials (medium/large dogs
and small breed dogs) of 4-weeks duration, each of which included 45 dogs divided
equally among a test group, a positive control group, and a negative control group.
Significant reductions in both plaque (p < 0.001) and gingivitis (p < 0.001) were
observed in the test group in comparison to both the negative and positive control
groups. This study also demonstrated that plaque was significantly reduced in the
gingival segment (p < 0.001) in addition to the whole tooth score (p < 0.001). No
adverse effects were noted and brushing was well tolerated by all dogs. This study
establishes a highly effective method for achieving plaque reduction in dogs.
AN - rayyan-563562472
AU - Milella, L.
AU - Beckman, B.
AU - Kane, J. S.
DO - 10.1177/089875641403100304
IS - 3
PY - 2014
SN - ["0898-7564", "2470-4083"]
SP - 160-167
ST - Evaluation of an Anti-Plaque Gel for Daily Toothbrushing
T2 - JOURNAL OF VETERINARY DENTISTRY
TI - Evaluation of an Anti-Plaque Gel for Daily Toothbrushing
VL - 31
ID - 15846
ER -
TY - JOUR
AB - OLP has many clinical presentations. Some lesions of OLP require no
treatment. Some must be managed for 20 years or more. The differential diagnosis of
OLP is difficult and varied. Dermatologists should consider consultation with a
dentist or specialist in oral medicine for diagnosis and management of lesions of
OLP.
AN - rayyan-563561063
AU - Miles, D. A.
AU - Howard, M. M.
DO - 10.1016/S0733-8635(05)70356-9
IS - 2
KW - allopurinol
amalgam
anxiolytic agent
betamethasone valerate
clobetasol propionate
clotrimazole
corticosteroid
cyclosporine
dexamethasone
diethyldithiocarbamic acid
fluocinonide
furosemide
griseofulvin
hydralazine
isotretinoin
minocycline
naproxen
penicillamine
prednisone
quinidine
retinol
triclosan
basal cell
cellular immunity
cytotoxic T lymphocyte
dentist
gel
geographic tongue
gingivitis
helper cell
human
intralesional drug administration
leukoplakia
lichen planus
malignant transformation
mouth hygiene
ointment
prescription
priority journal
review
thrush
tooth plaque
Wart virus
decadron
kenalog
lidex
valisone
LA - English
PY - 1996
SN - 0733-8635
SP - 281-290
ST - Diagnosis and management of oral lichen planus
T2 - DERMATOL. CLIN.
TI - Diagnosis and management of oral lichen planus
VL - 14
ID - 14437
ER -
TY - JOUR
AB - BACKGROUND: Aggressive periodontitis (AgP) is associated with an extensive
and rapid destruction of periodontal tissues. Unpredictable treatment outcomes of
the disease are consequences of various cross-linked factors. Antimicrobial
adjunctive treatment is routinely used as a part of non-surgical periodontal
treatment (NSPT) of AgP. AIM: Therefore, the aim of this study was to compare the
effects of active periodontal treatment (APT) combined with systemic antibiotics
with mechanical debridement alone, in patients with generalized AgP (GAgP).
METHODS: Two groups, consisting of 10 participants each, were randomly formed. Both
groups were clinically and microbiologically tested and monitored for 3 months.
Test group received APT with antimicrobial supplementation (amoxicillin and
metronidazole [AMX-MET]). Patients from the control group were treated by APT only.
Clinical and microbiological parameters were recorded at baseline and 3 months
following the NSPT. Clinical measurements involved probing depth, clinical
attachment level, bleeding on probing, and plaque index. Samples of subgingival
crevicular fluid were analyzed by qualitative polymerase chain reaction. RESULTS:
Significant improvement of all clinical parameters was observed 3 months following
the NSPT (p < 0.05), but significant difference between groups was not found (p >
0.05). Periodontal pathogens’ detection between baseline and 3 months follow-up was
also not statistically significant in both examined groups (p > 0.05). CONCLUSION:
Similarity of results obtained in both treatment groups underlined the key role of
APT in the treatment of AgP. The AMX-MET supplementation did not improve clinical
and microbiological outcomes, when compared to APT alone. Longer follow-up period,
with larger sample, could provide a more comprehensive insight into this issue.
AN - rayyan-563560044
AU - Milinkovic, I.
AU - Mijailovic, I.
AU - Markovic, A.
AU - Janjic, B.
AU - Nikolic, N.
AU - Milasin, J.
AU - Milicic, B.
AU - Aleksic, Z.
AU - Vasovic, D.
DO - 10.3889/oamjms.2021.6855
KW - mechanical probe
UNC 15
amoxicillin
antibiotic agent
metronidazole
adult
Aggregatibacter
article
bleeding on probing
clinical article
clinical assessment
clinical attachment
clinical evaluation
controlled study
dental debridement
DNA extraction
female
follow up
gene amplification
gingivitis
human
lactation
male
microbiology
middle aged
mouth hygiene
periodontics
plaque index
pregnancy
prevalence
smoking
subgingival crevicular fluid
systemic therapy
treatment outcome
Treponema denticola
LA - English
PY - 2021
SN - 1857-9655
SP - 149-154
ST - Adjunctive application of systemic antibiotics in non-surgical aggressive
periodontitis treatment: Clinical and microbiological findings
TI - Adjunctive application of systemic antibiotics in non-surgical aggressive
periodontitis treatment: Clinical and microbiological findings
VL - 9
ID - 13418
ER -
TY - JOUR
AB - Periodontal disease is an inflammatory condition of the tissues of the
periodontium that affects up to 90% of the world's population. Emerging antibiotic
and antimicrobial resistance in oral biofilms has sparked off an increased interest
in the potential of medicinal plants to treat periodontal pathologies. The last
decade has seen a surge in numbers of in vitro and in vivo studies on herbs
traditionally used for their anti-bacterial properties in ethno-pharmacological
applications. This review paper assesses the current status and role of medicinal
plants in the treatment and management of periodontal disease.
AN - rayyan-563560253
AU - Milovanova-Palmer, J.
AU - Pendry, B.
DO - 10.1016/j.hermed.2018.02.004
mouthwash
article
chewing gum
clinical research
gel
gingivitis
herbal medicine
medicinal plant
nonhuman
periodontal disease
periodontitis
priority journal
systematic review
topical treatment
LA - English
PY - 2018
SN - ["2210-8041", "2210-8033"]
SP - 33-48
ST - Is there a role for herbal medicine in the treatment and management of
periodontal disease?
T2 - J. Herbal Med.
TI - Is there a role for herbal medicine in the treatment and management of
periodontal disease?
VL - 12
ID - 13627
ER -
TY - JOUR
AB - Dental pathology remains a global health problem affecting both children and
adults. The most important dental diseases are dental caries and periodontal
pathologies. The main cause of oral health problems is overpopulation with
pathogenic bacteria and for this reason, conventional therapy can often be
ineffective due to bacterial resistance or may have unpleasant side effects. For
that reason, studies in the field have focused on finding new therapeutic
alternatives. Special attention is paid to the plant kingdom, which offers a wide
range of plants and active compounds in various pathologies. This review focused on
the most used plants in the dental field, especially on active phytocompounds, both
in terms of chemical structure and in terms of mechanism of action. It also
approached the in vitro study of active compounds and the main types of cell lines
used to elucidate the effect and mechanism of action. Thus, medicinal plants and
their compounds represent a promising and interesting alternative to conventional
therapy.
AN - rayyan-563562629
AU - Milutinovici, R. A.
AU - Chioran, D.
AU - Buzatu, R.
AU - Macasoi, I.
AU - Razvan, S.
AU - Chioibas, R.
AU - Corlan, I. V.
AU - Tanase, A.
AU - Horia, C.
AU - Popovici, R. A.
AU - Dinu, S.
AU - Dehelean, C.
AU - Scurtu, A.
AU - Pinzaru, I.
AU - Soica, C.
DO - 10.3390/plants10102148
IS - 10
PY - 2021
SN - 2223-7747
ST - Vegetal Compounds as Sources of Prophylactic and Therapeutic Agents in
Dentistry
T2 - PLANTS-BASEL
TI - Vegetal Compounds as Sources of Prophylactic and Therapeutic Agents in
Dentistry
VL - 10
Y2 - 10
ID - 16003
ER -
TY - JOUR
AB - Human β-defensin-2 (hBD-2) is an antimicrobial peptide with a broad spectrum
of antimicrobial activity against bacteria, yeast and fungi. Here, we analyzed the
transcriptional regulation of hBD-2 in cultured human cervical carcinoma (HeLa)
cells with or without lipopolysaccharide (LPS). DNA from position -329 to -39 in
the hBD-2 promoter region contained the consensus binding sites for transcription
factors, one site for nuclear factor for IL-6 expression (NF-IL6) and two sites for
nuclear factor-κB (NF-κB). Reporter gene assays for promoter activity revealed that
the region had the highest level of responsiveness to LPS. Furthermore, mutations
in both of the NF-κB binding sites caused a significant reduction of the
responsiveness to LPS, whereas mutation in the NF-IL6 binding site resulted in an
elevation of the basal promoter activity. Electrophoretic mobility shift assays
demonstrated that LPS induced the binding of HeLa nuclear factors to 60-bp probe
containing the two NF-κB binding sites, suggesting that the sites were essential
for the binding. Our results suggest that the two NF-κB binding sites contribute to
LPS-mediated hBD-2 transcription while the NF-IL6 binding site represses LPS-
independent hBD-2 transcription in the HeLa cells. © 2005 Federation of European
Microbiological Societies. Published by Elsevier B.V. All rights reserved.
AN - rayyan-563560785
AU - Mineshiba, J.
AU - Myokai, F.
AU - Mineshiba, F.
AU - Matsuura, K.
AU - Nishimura, F.
AU - Takashiba, S.
DO - 10.1016/j.femsim.2005.01.008
IS - 1
KW - beta defensin 2
Escherichia coli lipopolysaccharide
genomic DNA
interleukin 6
nuclear factor
article
binding site
cell culture
consensus
controlled study
gene mutation
gene probe
HeLa cell line
human
human cell
nucleotide sequence
priority journal
promoter region
protein expression
reporter gene
LA - English
PY - 2005
SN - 0928-8244
SP - 37-44
ST - Transcriptional regulation of β-defensin-2 by lipopolysaccharide in cultured
human cervical carcinoma (HeLa) cells
T2 - FEMS Immunol. Med. Microbiol.
TI - Transcriptional regulation of β-defensin-2 by lipopolysaccharide in cultured
human cervical carcinoma (HeLa) cells
VL - 45
ID - 14159
ER -
TY - JOUR
AB - BACKGROUND: As a derivative of natural biological material chitosan,
carboxymethyl chitosan has a wide application prospect in tissue engineering due to
its unique water-solubility, film-forming and sustained-release properties.
OBJECTIVE: To review the advantages of carboxymethyl chitosan compared with
chitosan and its application in oral tissue regeneration. METHODS: PubMed and CNKI
were searched using the key words of “carboxymethyl chitosan AND Tissue
engineering, carboxymethyl chitosan AND (dentistry OR stomatology)” for articles
published from January 2006 to October 2021. Preliminary screening was conducted
through reading and analysis to exclude duplicate articles and low-correlation
articles. Eventually, 51 articles were included for result analysis. RESULTS AND
CONCLUSION: Carboxymethyl chitosan, as a non-toxic material with valuable
biocompatibility and biodegradation, has made ideal progresses in bone tissue
regeneration, tooth tissue regeneration and periodontal tissue regeneration.
Carboxymethyl chitosan has better water solubility, membrane formation and ion
binding properties than chitosan, which greatly expands its application in oral
tissue engineering. Carboxymethyl chitosan has achieved the expected experimental
results whether it is used alone to exert antibacterial effect and promote cell
proliferation and differentiation, or used as a scaffold material, hydrogel,
modified material and biological active ingredients and growth factors.
AN - rayyan-563559754
AU - Mingrui, Z.
AU - Haiyan, L.
AU - Bing, L.
AU - Xiuping, W.
DO - 10.12307/2023.019
IS - 3
KW - carboxymethyl chitosan
chitosan
unclassified drug
article
data analysis
data extraction
dental procedure
human
mouth tissue
stomatology
tissue engineering
tissue regeneration
LA - Chinese
PY - 2023
SN - 2095-4344
SP - 447-452
ST - Application of carboxymethyl chitosan in tissue engineering of stomatology
TI - Application of carboxymethyl chitosan in tissue engineering of stomatology
VL - 27
ID - 13128
ER -
TY - JOUR
AB - Objectives: Optimization of therapy and prophylaxis of generalized
periodontitis (GP) and chronic gingivitis (CG) by improvement of extemporal
medicines in rinse and gel forms for topical treatment. Methods: Pharmacoeconomic
and comparative analysis of treatment schemes effectiveness for existing
mechanical/instrumental therapy and modified complexes for patients with
periodontal diseases with presence comorbidities before local treatment and one
month after for two patient groups with GP/CG main (25 person –modified complexes)
and comparison (23 person–based treatment). Results: Were developed improved
extemporal medicine complexes for treatment of periodontal diseases for patients
with chronic hepatitis C (HCV) and iron deficiency anemia (IDA). Effective minimum
and maximum value of ingredients were analyzed and optimal proportions of
ingredients were chosen. Before treatment, level of dental indexes of patients in
corresponding subgroups of the main and comparison group did not differ
significantly (p> 0.05). By adding of new components we provide anti-inflammatory,
capillary-membrane-stabilizing, wound-healing, anti-allergic, immune-modulating and
hepatic-protective activity. Were ensured antimicrobial and antifungal activity of
modified forms (min increase - 5,9%, max - 38,9%), increase saliva secretion rate
to 2,08 ml/min, reducing its viscosity to 1,42 mPa×c, which is especially important
for patients with HCV and IDA. Conclusions: After treatment, periodontal indexes
PBI and PDI were significantly lower (min decrease - 19,6%, max - 54,3%), in main
group relative to the corresponding indicators of comparison group (p<0.05). This
indicates positive effect of the use of modified complex for treatment and
prophylaxis of chronic gingivitis and generalized periodontitis for patients with
presence comorbidities. In spite of increasing cost of one dose the remission
period increased twice (from 3 to 6 months).
AN - rayyan-563560236
AU - Minko, L.
AU - Blavatska, O.
AU - Slaba, O.
AU - Sichkoriz, K.
DO - 10.1016/j.jval.2018.09.2555
endogenous compound
protein disulfide isomerase
adult
antifungal activity
capillary wall
chronic hepatitis C
clinical article
comorbidity
conference abstract
controlled study
female
gingivitis
human
iron deficiency anemia
local therapy
male
periodontal index
pharmacoeconomics
prophylaxis
remission
salivation
secretion rate
viscosity
wound healing
LA - English
PY - 2018
SN - ["1524-4733", "1098-3015"]
SP - S432
ST - COMPARATIVE EFFECTIVENESS OF INTEGRATED LOCAL TREATMENTS OF GENERALIZED
PERIODONTITIS AND CHRONIC GINGIVITIS
T2 - Value Health
TI - COMPARATIVE EFFECTIVENESS OF INTEGRATED LOCAL TREATMENTS OF GENERALIZED
PERIODONTITIS AND CHRONIC GINGIVITIS
VL - 21
ID - 13610
ER -
TY - JOUR
AB - Osteonecrosis of the jaw (ONJ) is a site specific osseous pathology,
characterized by chronic exposed bone in the mouth, which needs to be reinforced
periodically within the medical literature. ONJ is a clinical entity with many
possible aetiologies and its pathogenesis is not well understood. The risk factors
for ONJ include bisphosphonates treatments, head and neck radiotherapy, dental
procedures involving bone surgery, and trauma. Management of ONJ has centred on
efforts to eliminate or reduce severity of symptoms, to slow or prevent the
progression of disease, and to eradicate diseased bone.This case describes a rare
case of ONJ in a 64-year-old Caucasian male diagnosed with multiple myeloma stage
III. The lesion was related to a traumatic injury during mastication. Eighteen
months ago in the same area the molar 37 was extracted, achieving a complete
satisfactory healing, when only 2 doses of zoledronic acid had been administered.
Actinomyces bacterial aggregates were also identified in the microscopic
analysis.The management of this osteonecrotic lesion included antibiotic treatment
and chlorhexidine topical gel administration. The evolution was monitored every two
weeks until patient's death. The authors provide a discussion of the etiology,
pathogenesis, diagnosis, and management. This case report may shed light on the
controversies about concomitant factors and mechanisms inducing ONJ.
AN - rayyan-563560456
AU - Miranda-Rius, J.
AU - Brunet-Llobet, L.
AU - Lahor-Soler, E.
AU - Giménez-Rubio, J. A.
DO - 10.1155/2014/281313
KW - amoxicillin
chlorhexidine
corticosteroid
metronidazole
zoledronic acid
actinomycosis
adult
antibiotic prophylaxis
antibiotic therapy
article
bone density
case report
Caucasian
follow up
hemoptysis
histopathology
human
jaw osteonecrosis
male
middle aged
mortality
multiple myeloma
pancytopenia
patient monitoring
periodontitis
pneumonia
priority journal
tooth extraction
tooth pain
LA - English
PY - 2014
SN - ["1687-9635", "1687-9627"]
ST - Concomitant factors leading to an atypical osteonecrosis of the jaw in a
patient with multiple myeloma
T2 - Case Rep. Med.
TI - Concomitant factors leading to an atypical osteonecrosis of the jaw in a
patient with multiple myeloma
VL - 2014
ID - 13830
ER -
TY - JOUR
AB - The incidence of cardiovascular disorders, especially coronary artery disease
and atherosclerosis, is increasing alarmingly. Clarifying the underlying causes is
of the utmost importance and should be elucidated in order to reduce this growing
trend. Periodontitis is known as a chronic destructive disease with sophisticated
pathophysiological mechanisms that slowly impose negative effects not only on the
oral tissues but also on distant organs. Additionally, it has been shown in many
studies that atherosclerosis and periodontitis utilized common inflammatory
signaling pathways and mediators. Several lines of evidence have demonstrated the
signatures of periodontitis-related bacteria in atherosclerotic plaque specimens.
It is proposed that virulent proteins of these bacteria probably accelerate the
initiation or development of plaque formation on the inner walls of the coronary
arteries. Proteomics techniques are very sensitive and have a global point of view.
They can help to discover host factors and pathogen-related biomarkers. This review
summarizes the studies focused on the three most important bacterial species
involved in both diseases and presents recent findings about the proteomic
evaluation of virulence factors of these bacteria. The known mechanisms of action
of the virulence factors are also described.
AN - rayyan-563560274
AU - Mirnejad, R.
AU - Razeghian-Jahromi, I.
AU - Sepehrimanesh, M.
AU - Zibaeenezhad, M. J.
AU - Lopez-Jornet, P.
DO - 10.2174/1389203719666180625111449
IS - 11
KW - adenylosuccinate synthase
anthranilate synthase
bacterial protein
CD14 antigen
endopeptidase Clp
fibronectin
gingipain R
glutamate dehydrogenase
glutamate formiminotransferase
interleukin 1beta
interleukin 6
lipid A
lipopolysaccharide
proteome
virulence factor
atherosclerosis
bacterial infection
coronary artery disease
gene overexpression
human
inflammation
mass spectrometry
nonhuman
periodontitis
protein expression
proteomics
review
Western blotting
LA - English
PY - 2018
SN - ["1875-5550", "1389-2037"]
SP - 1124-1130
ST - A proteomic analysis of the virulence factors of three common bacterial
species involved in periodontitis and consequent possible atherosclerosis: A
narrative review
T2 - Curr. Protein Pept. Sci.
TI - A proteomic analysis of the virulence factors of three common bacterial
species involved in periodontitis and consequent possible atherosclerosis: A
narrative review
VL - 19
ID - 13648
ER -
TY - JOUR
AB - OBJECTIVE: To compare and evaluate the clinical efficacy of 1% Metformin gel
and oral Doxycycline in adjunct to SRP on clinical and biochemical parameters in
patients having localized moderate chronic periodontitis. METHODOLOGY: This
randomized open-label clinical trial was held at Bahria Dental College Hospital by
convenient sampling technique from October 2019 to March 2020. Sixty systemically
healthy, males and females aged 30-50 years, diagnosed with localized moderate
chronic periodontitis were enrolled. Molars with deepest PPD, CAL, PI, and mSBI
were included. Patients with a history of periodontal therapy and mouthwashes were
excluded. Patients were divided randomly into two groups with 30 in each. Group A
had SRP and Doxycycline and Group B received Metformin 1% gel intra-pocket with SRP
at day 0. Clinical parameters were evaluated on days 0, 45, and 90. TNFα was
evaluated on days 0 and 90. Results were statistically analyzed using SPSS software
version 23. RESULTS: Group B showed a significant reduction in PPD and CAL compared
to group A while PI and mSBI were found non-significant. TNFα was significantly
reduced in group B on day 90. CONCLUSION: 1% Metformin intra-pocket gel has
produced more beneficial effects on clinical and biochemical parameters in
comparison to conventional Doxycycline in adjunct to SRP in localized moderate
chronic periodontitis.
AN - rayyan-563559980
AU - Mirza, M.
AU - Karim, N.
AU - Kadri, W. B.
AU - Asghar, S.
DO - 10.22442/jlumhs.2021.00844
IS - 3
KW - doxycycline
metformin
adult
article
clinical assessment
clinical trial
controlled study
drug efficacy
female
human
male
plaque index
LA - English
PY - 2021
SN - ["2309-8627", "1729-0341"]
SP - 204-208
ST - Clinical efficacy of 1% metformin gel and systemic doxycyline in chronic
periodontitis: A randomized clinical trial
T2 - J. Liaquat Univ. Med. Health Sci.
TI - Clinical efficacy of 1% metformin gel and systemic doxycyline in chronic
periodontitis: A randomized clinical trial
VL - 20
ID - 13354
ER -
TY - JOUR
AB - Introduction: Dental implant failure due to periodontal disease caused by
anaerobic pathogens occurs, especially in the first year of implant placement. The
aim of this clinical trial study was to compare the antibacterial effect of
tetracycline gel and gel containing tetracycline-loaded mesoporous silica
nanoparticles (MSNs) in the gingival crevice fluid of the implant-abutment junction
as a randomized clinical trial study. Materials and Methods: Fourteen patients
applying for implants in the posterior mandibular region were included in the
study. During the uncovering session, tetracycline gel and gel containing
tetracycline-loaded MSNs were placed in two implants and no substance was placed in
the control group. Then, in three sessions, including molding, prosthesis delivery,
and one month after delivery, the patient's gingival fluid was sampled and the
number of bacteria in the gingival fluid was measured by colony-forming units
(CFU/mL). Results: The results of this study showed that in all three stages of
sampling, the use of tetracycline gel and gel containing MSNs loaded with
tetracycline significantly reduced the CFU/mL of gingival crevice fluid compared to
the control group. Tetracycline-loaded MSNs gel showed significantly lower CFU/mL
than tetracycline gel. The release of tetracycline from nanoparticles keep continue
for a longer time compared to tetracycline gel. Conclusion: The use of nano-based
delivery systems containing antibiotics inside the implant fixture can reduce the
bacterial count of the implant-abutment junction and then improve implant
stability.
AN - rayyan-563559774
AU - Mirzaali, F.
AU - Dizaj, S. M.
AU - Shahi, S.
AU - Memar, M. Y.
AU - Parnia, F.
DO - 10.2174/2211738511666230106151403
IS - 2
sonicator
tooth implant
antibiotic agent
gel
gentamicin
phytomenadione
tetracycline
zirconia nanoparticle
adult
aerotolerance test
anaerobic bacterium
article
bacterial count
bacterial growth
clinical article
colony formation
colony forming unit
dental implant failure
dentinal fluid
female
Friedman test
gingival fluid
gingivitis
human
male
Shapiro wilk test
tolerance test
Wilcoxon signed ranks test
LA - English
PY - 2023
SN - ["2211-7393", "2211-7385"]
SP - 208-216
ST - The Antibacterial Effect of Tetracycline-loaded Mesoporous Silica
Nanoparticles in the Gingival Fluid at Implant-abutment Junction: A Randomized
Clinical Trial Study
T2 - Pharm. Nanotechnology
TI - The Antibacterial Effect of Tetracycline-loaded Mesoporous Silica
Nanoparticles in the Gingival Fluid at Implant-abutment Junction: A Randomized
Clinical Trial Study
VL - 11
ID - 13148
ER -
TY - JOUR
AB - Context: Periodontitis is primarily an inflammatory condition caused by an
array of microorganisms present in dental plaque. Elimination or adequate
suppression of periodontal pathogens in the subgingival microflora is essential for
adequate periodontal healing to take place. The development of subgingivally placed
controlled delivery systems has provided the possibility of effective intrapocket
concentration levels of antibacterial agents for an extended period of time,
resulting in an altered subgingival flora and enhanced healing of the attachment
apparatus. Although a number of synthetic antimicrobial agents are being used as
local drug delivery, currently, pharmaceutical technology development has focused
on the ingredients derived from nature. Natural phytochemicals have proven to be
worthy substitutes of their synthetic and chemical-laden counterparts owing to
their extensive natural activity, advanced safety margins, and inferior costs so
that they can be of huge benefits, especially to the lower socioeconomic population
around the world and spirulina platensis (SP) is one such emerging remedy. Aims:
The aim of the study was to develop three controlled release drug delivery systems
containing different concentrations of SP to be used inside the periodontal
pockets. The study also aimed to determine the antimicrobial activity of all the
three concentrations of SP drug delivery system against major periodontopathic
microorganisms and to test the physicochemical properties of the delivery system
that exhibited maximum antimicrobial efficacy so that the suitability of its use
inside the periodontal pocket could be determined. Settings and Design: The study
was an in vitro experimental design. Subjects and Methods: Three different
controlled release SP hydrogels (4%, 6%, and 12%) to be used inside the periodontal
pockets were developed and antibacterial properties against periodontal pathogens
were assessed. The hydrogel exhibiting maximum antimicrobial efficacy was then
tested of physicochemical and mechanical properties to determine its suitability of
its use inside the periodontal pocket. Statistical Analysis Used: Data were
analyzed using one-way analysis of variance. Post hoc Tukey honestly significant
difference test was used for comparison within the group and between the different
groups. Results: 12% SP hydrogel was found to have maximum antimicrobial efficacy
against major periodontal pathogens, and its physicochemical and mechanical
properties were also optimum to be used inside the periodontal pocket. Conclusions:
12% SP hydrogel can act as a promising adjunct to periodontal mechanical therapy
and may also reduce the chances of more invasive periodontal surgical procedures.
AN - rayyan-563560009
AU - Mishra, S.
AU - Johnson, L.
AU - Sangha, K. S.
AU - Gupta, V.
AU - Agarwal, S.
AU - Rajput, S.
DO - 10.4103/jpbs.JPBS_446_20
IS - 2
carbomer
doxycycline
hydrogel
macrogol
macrogol 400
methyl paraben
metronidazole
propyl paraben
Spirulina extract
Spirulina platensis gel
triethanolamine
unclassified drug
Arthrospira platensis
article
comparative study
controlled study
disk diffusion
drug efficacy
drug quality
Fusobacterium
in vitro study
mechanics
nonhuman
periodontal pocket
physical chemistry
Spirulina
spray drying
zone of inhibition
LA - English
PY - 2021
SN - 0975-7406
SP - 178-187
ST - An in vitro study to determine the physicochemical, mechanical, and
antibacterial properties of a novel spirulina containing controlled release
intrapocket drug delivery system
TI - An in vitro study to determine the physicochemical, mechanical, and
antibacterial properties of a novel spirulina containing controlled release
VL - 13
ID - 13383
ER -
TY - JOUR
AB - Background: Extracts of medicinal plant like lemongrass offer a new choice
for optional antimicrobial therapy against various oral microorganisms. The
objective of this study was to assess, verify, and compare the antimicrobial
effectiveness of locally administered 2% lemongrass gel and 10% doxycycline hyclate
gel as an adjunct to scaling and root planing (SRP) in treating chronic
periodontitis. Method: This is a double-blind parallel arm randomized controlled
study. Forty subjects were randomly divided into Group A and B for 2% lemongrass
gel and 10% doxycycline hyclate gel, respectively. The clinical assessments of
Gingival Index (GI), Plaque Index (PI), Probing Pocket Depth (PPD), and Clinical
Attachment Level (CAL) together with microbial colony counts for Porphyromonas
gingivalis, Actinomyces naeslundii, and Prevotella intermedia were done at
baseline, 1st month, and 3rd month follow-ups. Results: The results showed there
was a significant reduction in the mean scores of GI, PPD, and CAL clinical indices
from baseline to the 1st and 3rd month follow-ups in both the 2% lemongrass gel and
10% doxycycline gel groups (p < 0.05). Similarly, there was significant reduction
in mean CFU scores for all periodontal pathogens from baseline to 1st and 3rd month
follow-ups in both the 2% lemongrass gel and 10% doxycycline gel groups (p < 0.05).
Conclusions: It could be concluded that the local delivery of 2% lemongrass gel as
an adjunct to scaling and root planing is effective and comparable to 10%
doxycycline gel in the treatment of chronic periodontitis.
AN - rayyan-563562219
AU - Mittal, P.
AU - Gokhale, S. T.
AU - Manjunath, S.
AU - Al-Qahtani, S. M.
AU - Al Magbol, M.
AU - Nagate, R. R.
AU - Tikare, S.
AU - Chaturvedi, S.
AU - Agarwal, A.
AU - Venkataram, V.
DO - 10.3390/polym14142766
IS - 14
PY - 2022
SN - 2073-4360
ST - Comparative Evaluation of Locally Administered 2% Gel Fabricated from
Lemongrass Polymer and 10% Doxycycline Hyclate Gel as an Adjunct to Scaling and
Root Planing in the Treatment of Chronic Periodontitis-A Randomized Controlled
Trial
T2 - POLYMERS
TI - Comparative Evaluation of Locally Administered 2% Gel Fabricated from
Trial
VL - 14
Y2 - 7
ID - 15593
ER -
TY - JOUR
AB - Background: Extracts of medicinal plant like lemongrass offer a new choice
for optional antimicrobial therapy against various oral microorganisms. The
objective of this study was to assess, verify, and compare the antimicrobial
effectiveness of locally administered 2% lemongrass gel and 10% doxycycline hyclate
gel as an adjunct to scaling and root planing (SRP) in treating chronic
periodontitis. Method: This is a double-blind parallel arm randomized controlled
study. Forty subjects were randomly divided into Group A and B for 2% lemongrass
gel and 10% doxycycline hyclate gel, respectively. The clinical assessments of
Gingival Index (GI), Plaque Index (PI), Probing Pocket Depth (PPD), and Clinical
Attachment Level (CAL) together with microbial colony counts for Porphyromonas
gingivalis, Actinomyces naeslundii, and Prevotella intermedia were done at
baseline, 1st month, and 3rd month follow-ups. Results: The results showed there
was a significant reduction in the mean scores of GI, PPD, and CAL clinical indices
from baseline to the 1st and 3rd month follow-ups in both the 2% lemongrass gel and
10% doxycycline gel groups (p < 0.05). Similarly, there was significant reduction
in mean CFU scores for all periodontal pathogens from baseline to 1st and 3rd month
follow-ups in both the 2% lemongrass gel and 10% doxycycline gel groups (p < 0.05).
Conclusions: It could be concluded that the local delivery of 2% lemongrass gel as
an adjunct to scaling and root planing is effective and comparable to 10%
doxycycline gel in the treatment of chronic periodontitis.
AN - rayyan-563560942
AU - Mittal, P.
AU - Gokhale, S. T.
AU - Manjunath, S.
AU - Magbol, M. A.
AU - Nagate, R. R.
AU - Tikare, S.
AU - Chaturvedi, S.
AU - Agarwal, A.
AU - Venkataram, V.
DO - 10.3390/polym14142766
IS - 14
LA - eng
N1 - Department of Periodontology, Dental College Azamgarh, Azamgarh 276128, Uttar
Pradesh, India.; Department of Periodontics and Community Dental Sciences, College
of Dentistry, King Khalid University, Abha 61421, Saudi Arabia.; Department of
Periodontics, Institute of Dental Sciences, Bareilly 243006, Uttar Pradesh, India.;
Department of Periodontics and Community Dental Sciences, College of Dentistry,
King Khalid University, Abha 61421, Saudi Arabia.; Department of Periodontics and
Community Dental Sciences, College of Dentistry, King Khalid University, Abha
61421, Saudi Arabia.; Department of Periodontics and Community Dental Sciences,
College of Dentistry, King Khalid University, Abha 61421, Saudi Arabia.; Department
of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid
University, Abha 61421, Saudi Arabia.; Department of Prosthetic Dentistry, College
of Dentistry, King Khalid University, Abha 61421, Saudi Arabia.; Community Health
Center, Puranpur, Pilibhit 262121, Uttar Pradesh, India.; Department of Pedodontics
& Preventive Dentistry, KVG Dental College & Hospital, Sullia 574327, Karnataka,
India.
PY - 2022
Trial
T2 - Polymers
Trial
VL - 14
Y2 - 7 y3 - 6
ID - 14316
ER -
TY - JOUR
AN - rayyan-563561589
AU - Mittal, P.
AU - Gokhale, S. T.
AU - Manjunath, S.
AU - Magbol, M. Al
AU - Nagate, R. R.
AU - Tikare, S.
AU - Chaturvedi, S.
AU - Agarwal, A.
AU - Venkataram, V.
DO - 10.3390/polym14142766
IS - 14
PY - 2022
Root Planing in the Treatment of Chronic Periodontitis—A Randomized Controlled
Trial
T2 - Polymers
Root Planing in the Treatment of Chronic Periodontitis—A Randomized Controlled
Trial
85134027581&doi=10.3390%2fpolym14142766&partnerID=40&md5=c75656c40e07a8fbba05178c5b
c899ed
VL - 14
ID - 14963
ER -
TY - JOUR
AB - The Capnocytophaga are inhabitants of the hypoxic human gingival crevice that
are normally prevented by neutrophils from causing periodontal and systemic
infection. To identify potential nonoxidative bactericidal mechanisms against
Capnocytophaga within human neutrophils, gel filtration chromatography was used to
fractionate neutrophil granule extracts. Seven granule fractions, designated A
through G, were obtained. The Capnocytophaga were most sensitive to killing by
fraction D. Fraction D exhibited substantial bactericidal activity under aerobic
and anaerobic conditions. The bactericidal activity associated with ion-exchange
subfractions D8-D11, which contained primarily cathepsin G as assessed by enzymatic
activity, amino acid composition, and NH2-terminal sequence. Heat-inactivation,
diisopropylfluorophosphate, PMSF, and N-benzyloxycarbonylglycylleucylphenylalanyl-
chloromethyl ketone inhibited bactericidal activity against Capnocytophaga
sputigena but not Escherichia coli. We conclude that (a) human neutrophil cathepsin
G is an important antimicrobial system against the Capnocytophaga, (b) the
bactericidal activity of cathepsin G against Capnocytophaga is oxygen independent,
and (c) an intact enzyme active site is involved in the killing of C. sputigena but
not E. coli. We suggest that human neutrophil cathepsin G is an important
antimicrobial system against certain oral bacteria and that cathepsin G kills
bacteria by two distinct mechanisms.
AN - rayyan-563561159
AU - Bodeau, A. L.
DO - 10.1172/JCI115172
IS - 5
KW - cathepsin G
article
Capnocytophaga
granular cell
human
human cell
neutrophil
nonhuman
priority journal
LA - English
PY - 1991
SN - 0021-9738
SP - 1585-1593
ST - In vitro killing of oral Capnocytophaga by granule fractions of human
neutrophils is associated with cathepsin G activity
T2 - J. CLIN. INVEST.
TI - In vitro killing of oral Capnocytophaga by granule fractions of human
neutrophils is associated with cathepsin G activity
VL - 87
ID - 14533
ER -
TY - JOUR
AB - The Capnocytophaga are inhabitants of the hypoxic human gingival crevice that
are normally prevented by neutrophils from causing periodontal and systemic
infection. To identify potential nonoxidative bactericidal mechanisms against
Capnocytophaga within human neutrophils, gel filtration chromatography was used to
fractionate neutrophil granule extracts. Seven granule fractions, designated A
through G, were obtained. The Capnocytophaga were most sensitive to killing by
fraction D. Fraction D exhibited substantial bactericidal activity under aerobic
and anaerobic conditions. The bactericidal activity associated with ion-exchange
subfractions D8-D11, which contained primarily cathepsin G as assessed by enzymatic
activity, amino acid composition, and NH2-terminal sequence. Heat-inactivation,
diisopropylfluorophosphate, PMSF, and N-
benzyloxycarbonylglycylleucylphenylalanylchloromethyl ketone inhibited bactericidal
activity against Capnocytophaga sputigena but not Escherichia coli. We conclude
that (a) human neutrophil cathepsin G is an important antimicrobial system against
the Capnocytophaga, (b) the bactericidal activity of cathepsin G against
Capnocytophaga is oxygen independent, and (c) an intact enzyme active site is
involved in the killing of C. sputigena but not E. coli. We suggest that human
neutrophil cathepsin G is an important antimicrobial system against certain oral
bacteria and that cathepsin G kills bacteria by two distinct mechanisms.
AN - rayyan-563562581
AU - Bodeau, A. L.
DO - 10.1172/JCI115172
IS - 5
PY - 1991
SN - 0021-9738
SP - 1585-1593
ST - INVITRO KILLING OF ORAL CAPNOCYTOPHAGA BY GRANULE FRACTIONS OF HUMAN
NEUTROPHILS IS ASSOCIATED WITH CATHEPSIN-G ACTIVITY
T2 - JOURNAL OF CLINICAL INVESTIGATION
TI - INVITRO KILLING OF ORAL CAPNOCYTOPHAGA BY GRANULE FRACTIONS OF HUMAN
NEUTROPHILS IS ASSOCIATED WITH CATHEPSIN-G ACTIVITY
VL - 87
Y2 - 5
ID - 15955
ER -
TY - JOUR
AB - The purpose of this study was to determine whether granule fractions of human
neutrophils differentially kill Actinobacillus actinomycetemcomitans and
Capnocytophaga spp. Granule extracts were subjected to gel filtration, and seven
fractions (designated A through G) were obtained. Under aerobic conditions at pH
7.0, representative strains of A. actinomycetemcomitans were killed by fraction D
and variably by fraction B. In contrast, the Capnocytophaga spp. were killed by
fractions C, D, F, and G. Fractions A (containing lactoferrin and myeloperoxidase)
and E (containing lysozyme) exerted little bactericidal activity under these
conditions. Anaerobiosis had little effect on the bactericidal activity of
fractions D and F but inhibited that of fractions B and C. Electrophoresis,
zymography, determination of amino acid composition, and N-terminal sequence
analysis revealed that fraction C contained elastase, proteinase 3, and azurocidin.
Fraction D contained lysozyme, elastase, and cathepsin G. Subfractions of C and D
containing elastase (subfraction C4), a mixture of elastase and azurocidin
(subfraction C5), and cathepsin G (subfraction D9) were found to be bactericidal.
The bactericidal effects of fraction D and subfraction D9 against A.
actinomycetemcomitans was not inhibited by heat inactivation, phenylmethylsulfonyl
fluoride, or N-benzyloxycarbonylglycylleucylphenylalanylchloromethyl ketone. We
conclude that (i) A. actinomycetemcomitans and Capnocytophaga spp. were sensitive
to the bactericidal effects of different neutrophil granule components, (ii) both
were sensitive to the bactericidal effects of neutral serine proteases, and (iii)
the killing of A. actinomycetemcomitans by cathepsin G-containing fractions was
independent of oxygen and neutral serine protease activity.
AN - rayyan-563562639
AU - Bodeau, A. L.
AU - Flemmig, T. F.
DO - 10.1128/IAI.59.10.3760-3767.1991
IS - 10
PY - 1991
SN - 0019-9567
SP - 3760-3767
ST - DIFFERENTIAL KILLING OF ACTINOBACILLUS-ACTINOMYCETEMCOMITANS AND
CAPNOCYTOPHAGA SPP BY HUMAN NEUTROPHIL GRANULE COMPONENTS
T2 - INFECTION AND IMMUNITY
TI - DIFFERENTIAL KILLING OF ACTINOBACILLUS-ACTINOMYCETEMCOMITANS AND
CAPNOCYTOPHAGA SPP BY HUMAN NEUTROPHIL GRANULE COMPONENTS
VL - 59
Y2 - 10
ID - 16013
ER -
TY - JOUR
AN - rayyan-563562130
AU - Bodeau, A. L.
AU - Murthy, A. R. K.
AU - Lehrer, R. I.
DO - 10.1177/00220345930720020801
IS - 2
PY - 1993
SP - 517-523
ST - In vitro Antimicrobial Activity of the Human Neutrophil Cytosolic S-100
Protein Complex, Calprotectin, Against Capnocytophaga sputigena
T2 - Journal of Dental Research
TI - In vitro Antimicrobial Activity of the Human Neutrophil Cytosolic S-100
Protein Complex, Calprotectin, Against Capnocytophaga sputigena
0027416772&doi=10.1177%2f00220345930720020801&partnerID=40&md5=b40db3818a24c608a019
867f7aa495ca
VL - 72
ID - 15504
ER -
TY - JOUR
AB - Calprotectin is a complex of two anionic proteins found in abundance in the
cytosol of neutrophils, certain macrophages, and oral epithelial keratinocytes.
Bacteria of the genus Capnocytophaga are pathogens of periodontal origin which can
cause systemic infection in neutropenic subjects. Recently, it has been observed
that Capnocytophaga may be internalized by neutrophils within the cytosol rather
than within a membrane-delimited phagosome. The purpose of this study was to test
the in vitro antibacterial effect of the cytosolic complex, calprotectin, against
Capnocytophaga sputigena. Calprotectin was purified from the cytosol of human
neutrophils by gel filtration and anion exchange FPLC, and it exerted potent in
vitro antimicrobial effects against C. sputigena. Net bacteriostatic activity was
exerted up to 18 h, after which bactericidal effects were observed. Both net
bacteriostatic and bactericidal activity occurred at concentrations above 20 mug/mL
and exhibited identical dose-response characteristics. Particle counts increased in
the presence of calprotectin, despite net bacteriostasis as assessed by changes in
colony-forming units (CFU). Dose-response characteristics and direct particle
counts suggested that net bacteriostatic effects were the result of balanced cell
division and death, rather than suspension of cell division. We conclude that
calprotectin can be a significant contributor to host defense against infection by
Capnocytophaga.
AN - rayyan-563562482
AU - Bodeau, A. L.
AU - Murthy, A. R. K.
AU - Lehrer, R. I.
DO - 10.1177/00220345930720020801
IS - 2
PY - 1993
SN - 0022-0345
SP - 517-523
ST - INVITRO ANTIMICROBIAL ACTIVITY OF THE HUMAN NEUTROPHIL CYTOSOLIC S-100
PROTEIN COMPLEX, CALPROTECTIN, AGAINST CAPNOCYTOPHAGA-SPUTIGENA
TI - INVITRO ANTIMICROBIAL ACTIVITY OF THE HUMAN NEUTROPHIL CYTOSOLIC S-100
PROTEIN COMPLEX, CALPROTECTIN, AGAINST CAPNOCYTOPHAGA-SPUTIGENA
VL - 72
Y2 - 2
ID - 15856
ER -
TY - JOUR
AB - Calprotectin is a complex of two anionic proteins found in abundance in the
cytosol of neutrophils, certain macrophages, and oral epithelial keratinocytes.
Bacteria of the genus Capnocytophaga are pathogens of periodontal origin which can
cause systemic infection in neutropenic subjects. Recently, it has been observed
that Capnocytophaga may be internalized by neutrophils within the cytosol rather
than within a membrane-delimited phagosome. The purpose of this study was to test
the in vitro antibacterial effect of the cytosolic complex, calprotectin, against
Capnocytophaga sputigena. Calprotectin was purified from the cytosol of human
neutrophils by gel filtration and anion exchange FPLC, and it exerted potent in
vitro antimicrobial effects against C. sputigena. Net bacteriostatic activity was
exerted up to 18 h, after which bactericidal effects were observed. Both net
bacteriostatic and bactericidal activity occurred at concentrations above 20
micrograms/mL and exhibited identical dose-response characteristics. Particle
counts increased in the presence of calprotectin, despite net bacteriostasis as
assessed by changes in colony-forming units (CFU). Dose-response characteristics
and direct particle counts suggested that net bacteriostatic effects were the
result of balanced cell division and death, rather than suspension of cell
division. We conclude that calprotectin can be a significant contributor to host
defense against infection by Capnocytophaga.
AN - rayyan-563561431
AU - Bodeau, A. L.
AU - Murthy, A. R.
AU - Lehrer, R. I.
DO - 10.1177/00220345930720020801
IS - 2
J2 - J Dent Res
KW - Amino Acid Sequence
Anti-Bacterial Agents/*pharmacology
Capnocytophaga/*drug effects
Cell Adhesion Molecules, Neuronal/chemistry/isolation & purification/*pharmacology
Cytosol/chemistry
Immunoblotting
Leukocyte L1 Antigen Complex
Molecular Sequence Data
S100 Proteins/physiology
LA - eng
N1 - Section of Oral Biology, UCLA School of Dentistry 90024-1668.
PY - 1993
SN - 0022-0345 (Print)
SP - 517-23
ST - In vitro antimicrobial activity of the human neutrophil cytosolic S-100
protein complex, calprotectin, against Capnocytophaga sputigena
T2 - Journal of dental research
TI - In vitro antimicrobial activity of the human neutrophil cytosolic S-100
protein complex, calprotectin, against Capnocytophaga sputigena
VL - 72
Y2 - 2
ID - 14805
ER -
TY - JOUR
AB - Local therapy of the oral cavity is used to treat conditions such as
gingivitis, oral candidosis, oral lesions, dental caries, xerostoma and oral
carcinomas. Delivery systems used include mouthwashes, aerosol sprays, chewing
gums, bioadhesive tablets, films, gels and pastes. There are three major problems
associated with drug therapy within the oral cavity: rapid elimination of drugs due
to the flushing action of saliva or the ingestion of food, the non-uniform
distribution of drugs within saliva on release from a solid or semisolid delivery
system and patient compliance in terms of taste. Prolonged contact time of a drug
with body tissue can significantly improve the clinical performance of many agents
used for treating oral disorders. These improvements range from better treatment of
local pathologies to improved drug bioavailability and controlled release to
enhanced patient compliance. There are abundant examples in the literature over the
past 15 years of these improvements using bioadhesive polymers. This manuscript
summarizes the innovations pertaining to formulation and treatments as described in
recent patents. © 2008 Bentham Science Publishers Ltd.
AN - rayyan-563560703
AU - Mizrahi, B.
AU - Domb, A. J.
DO - 10.2174/187221108784534126
IS - 2
KW - acrylic acid
alginic acid
antifungal agent
antiinfective agent
carbomer
carrageenan
chitosan
copolymer
drug carrier
gellan
hydroxymethylcellulose
iodine
macrogol
methylcellulose
miconazole
pectin
peptide derivative
polyacrylic acid
polycarbophil
polymacon
polymer
polyvinyl alcohol
povidone
pyrrole derivative
unindexed drug
xanthan
aqueous solution
article
biodegradability
cross linking
dental caries
drug absorption
drug decomposition
drug efficacy
drug formulation
drug release
drug research
drug safety
drug solubility
emulsion
gel
gingivitis
halitosis
human
hydrolysis
hydrophobicity
lozenge
mouth infection
mouth mucosa
mouth ulcer
mouthwash
mycosis
nonhuman
ointment
particle size
patent
periodontitis
physical chemistry
priority journal
tablet compression
tablet formulation
tissue structure
wettability
xerostomia
LA - English
PY - 2008
SN - 1872-2113
SP - 108-119
ST - Mucoadhesive polymers for delivery of drugs to the oral cavity
TI - Mucoadhesive polymers for delivery of drugs to the oral cavity
VL - 2
ID - 14077
ER -
TY - JOUR
AB - Curcumin exhibits antibacterial, antioxidant, and anti-inflammatory effects
and has been suggested as a treatment for inflammatory diseases. The study is aimed
at evaluating the effect of curcumin gel on serum levels of micronutrients (zinc,
copper, and magnesium) and proinflammatory cytokines (IL-1 beta and TNF-alpha) in
chronic periodontitis patients. Ninety subjects with an age of 25-54 were included
in this study. From the total number, 30 subjects with healthy periodontium
(control group) (mean age=37.30 +/- 7.08) were employed for the sole purpose of
obtaining the normal mean values of clinical, chemical, and immunological
parameters, and 60 with chronic periodontitis (mean age=36.73 +/- 6.22) were
divided randomly into 2 groups, of which each group included 30 subjects. Group A
received scaling and root planing SRP and curcumin gel injection covered by Coe
pack for 7 days, and group B received SRP alone covered by Coe pack. Clinical
parameters (plaque index, gingival index, bleeding on probing, pocket depth, and
clinical attachment loss measurements) and blood samples were collected before and
after 1 month of treatment to measure serum levels of zinc, copper, magnesium, IL-1
beta, and TNF-alpha. The results showed significant micronutrient alteration and
increase of proinflammatory cytokines in the chronic periodontitis group as
compared to healthy control (P <= 0.05), and curcumin gel had a significant effect
on the reduction of IL-1 beta, TNF-alpha, copper, and clinical parameters (P <=
0.05) and increase of zinc and magnesium levels after 1 month as compared to
baseline (P <= 0.05), nearly the same pattern for group B but with nonsignificant
differences for Zn (P>0.05). In conclusion, curcumin gel resulted in a more
significant reduction in clinical parameters, inflammatory mediators, and copper
and increase of zinc and magnesium levels as compared to SRP alone.
AN - rayyan-563562361
AU - Mohammad, C. A.
DO - 10.1155/2020/8850926
PY - 2020
SN - ["2314-6133", "2314-6141"]
ST - Efficacy of Curcumin Gel on Zinc, Magnesium, Copper, IL-1 beta, and TNF-alpha
in Chronic Periodontitis Patients
T2 - BIOMED RESEARCH INTERNATIONAL
TI - Efficacy of Curcumin Gel on Zinc, Magnesium, Copper, IL-1 beta, and TNF-alpha
in Chronic Periodontitis Patients
VL - 2020
Y2 - 10 y3 - 6
ID - 15735
ER -
TY - JOUR
copper, and magnesium) and proinflammatory cytokines (IL-1β and TNF-α) in chronic
periodontitis patients. Ninety subjects with an age of 25-54 were included in this
study. From the total number, 30 subjects with healthy periodontium (control group)
(mean age = 37:30 ± 7:08) were employed for the sole purpose of obtaining the
normal mean values of clinical, chemical, and immunological parameters, and 60 with
chronic periodontitis (mean age = 36:73 ± 6:22) were divided randomly into 2
groups, of which each group included 30 subjects. Group A received scaling and root
planing SRP and curcumin gel injection covered by Coe pack for 7 days, and group B
received SRP alone covered by Coe pack. Clinical parameters (plaque index, gingival
index, bleeding on probing, pocket depth, and clinical attachment loss
measurements) and blood samples were collected before and after 1 month of
treatment to measure serum levels of zinc, copper, magnesium, IL-1β, and TNF-α. The
results showed significant micronutrient alteration and increase of proinflammatory
cytokines in the chronic periodontitis group as compared to healthy control (P ≤
0:05), and curcumin gel had a significant effect on the reduction of IL-1β, TNF-α,
copper, and clinical parameters (P ≤ 0:05) and increase of zinc and magnesium
levels after 1 month as compared to baseline (P ≤ 0:05), nearly the same pattern
for group B but with nonsignificant differences for Zn (P > 0:05). In conclusion,
curcumin gel resulted in a more significant reduction in clinical parameters,
inflammatory mediators, and copper and increase of zinc and magnesium levels as
compared to SRP alone.
AN - rayyan-563560154
DO - 10.1155/2020/8850926
KW - Coe pack
copper
Curcuma longa extract
curcumin
curcumin gel
curenext
interleukin 1beta
magnesium
unclassified drug
zinc
adult
article
blood sampling
chemical parameters
clinical assessment
controlled study
copper blood level
drug efficacy
female
gingival index
human
human tissue
immunological parameters
magnesium blood level
male
plaque index
protein blood level
root planing
zinc blood level
LA - English
PY - 2020
SN - ["2314-6141", "2314-6133"]
ST - Efficacy of curcumin gel on zinc, magnesium, copper, IL-1β, and TNF-α in
TI - Efficacy of curcumin gel on zinc, magnesium, copper, IL-1β, and TNF-α in
VL - 2020
ID - 13528
ER -
TY - COMP
copper, and magnesium) and proinflammatory cytokines (IL-1β and TNF-α) in chronic
periodontitis patients. Ninety subjects with an age of 25-54 were included in this
study. From the total number, 30 subjects with healthy periodontium (control group)
(mean age = 37.30 ± 7.08) were employed for the sole purpose of obtaining the
normal mean values of clinical, chemical, and immunological parameters, and 60 with
chronic periodontitis (mean age = 36.73 ± 6.22) were divided randomly into 2
groups, of which each group included 30 subjects. Group A received scaling and root
planing SRP and curcumin gel injection covered by Coe pack for 7 days, and group B
received SRP alone covered by Coe pack. Clinical parameters (plaque index, gingival
index, bleeding on probing, pocket depth, and clinical attachment loss
measurements) and blood samples were collected before and after 1 month of
treatment to measure serum levels of zinc, copper, magnesium, IL-1β, and TNF-α. The
results showed significant micronutrient alteration and increase of proinflammatory
cytokines in the chronic periodontitis group as compared to healthy control (P ≤
0.05), and curcumin gel had a significant effect on the reduction of IL-1β, TNF-α,
copper, and clinical parameters (P ≤ 0.05) and increase of zinc and magnesium
levels after 1 month as compared to baseline (P ≤ 0.05), nearly the same pattern
for group B but with nonsignificant differences for Zn (P > 0.05). In conclusion,
curcumin gel resulted in a more significant reduction in clinical parameters,
inflammatory mediators, and copper and increase of zinc and magnesium levels as
compared to SRP alone.
AN - rayyan-563560950
CY - United States
DO - 10.1155/2020/8850926
J2 - Biomed Res Int
KW - Adult
Chronic Periodontitis/blood/*drug therapy
Copper/*blood
Curcumin/*therapeutic use
Female
Gels/*therapeutic use
Humans
Interleukin-1beta/*blood
Magnesium/*blood
Male
Micronutrients/blood
Middle Aged
Periodontal Index
Root Planing/methods
Tumor Necrosis Factor-alpha/*blood
Zinc/*blood
LA - eng
N1 - Department of Periodontology, College of Dentistry, Hawler Medical
University, Erbil, Kurdistan Region, Iraq.
PY - 2020
SP - 8850926
ST - Efficacy of Curcumin Gel on Zinc, Magnesium, Copper, IL-1β, and TNF-α in
Chronic Periodontitis Patients
T2 - BioMed research international
TI - Efficacy of Curcumin Gel on Zinc, Magnesium, Copper, IL-1β, and TNF-α in
VL - 2020
ID - 14324
ER -
TY - JOUR
AB - Adjunctive use of antimicrobials with scaling and root planing (SRP) is
necessary to better eradicate dental biofilm. Tetracycline (T) is the most commonly
used antimicrobial; however, it has limitations. This study evaluates the effect of
curcumin (CU) as adjunct to SRP on inflammatory markers, collagen fiber deposition,
and altered iron level. A total of 32 Wistar rats were divided into five groups: no
experimental periodontitis (healthy control), experimental periodontitis (EPD), EPD
treated with SRP alone (SRP), EPD treated with SRP+T (SRP+T), and EPD treated with
SRP+CU (SRP+CU). After 2 and 4 weeks of treatment, tissue samples were assessed by
hematoxylin and eosin, and special stains (Perls' stain and Masson's Trichrome) for
counting of inflammatory cells, angiogenesis, collagen fibers, and iron deposition.
Significant reductions in inflammatory cells infiltration and alveolar bone
resorption with angiogenesis and collagen fibers deposition were detected after 2
and 4 weeks in both SRP+T and SRP+CU groups. SRP+CU resulted in a significant
reduction in osteoclast numbers (week 2) and iron deposition (week 4) in bone
trabeculae as compared to SRP and SRP+T groups. The adjunctive use of CU showed
comparable results to T in the reduction in inflammation and bone resorption.
Furthermore, CU has potential osteogenesis and healing effects.
AN - rayyan-563561109
AU - Ali, K. M.
AU - Al-Rawi, R. A.
AU - Gul, S. S.
IS - 4
J2 - Antibiotics (Basel)
LA - eng
N1 - Department of Periodontology, College of Dentistry, Hawler Medical
University, Erbil 44001, Iraq.; Department of Periodontology, College of Dentistry,
Hawler Medical University, Erbil 44001, Iraq.; Department of Clinical Analysis,
College of Pharmacy, Hawler Medical University, Erbil 44001, Iraq.; Department of
Periodontics, College of Dentistry, University of Sulaimani, Sulaymaniyah 46001,
Iraq.
PY - 2022
SN - 2079-6382 (Print)
ST - Effects of Curcumin and Tetracycline Gel on Experimental Induced
Periodontitis as an Anti-Inflammatory, Osteogenesis Promoter and Enhanced Bone
Density through Altered Iron Levels: Histopathological Study
T2 - Antibiotics (Basel, Switzerland)
TI - Effects of Curcumin and Tetracycline Gel on Experimental Induced
Periodontitis as an Anti-Inflammatory, Osteogenesis Promoter and Enhanced Bone
VL - 11
Y2 - 4 y3 - 13
ID - 14483
ER -
TY - JOUR
AB - Adjunctive use of antimicrobials with scaling and root planing (SRP) is
necessary to better eradicate dental biofilm. Tetracycline (T) is the most commonly
used antimicrobial; however, it has limitations. This study evaluates the effect of
curcumin (CU) as adjunct to SRP on inflammatory markers, collagen fiber deposition,
and altered iron level. A total of 32 Wistar rats were divided into five groups: no
experimental periodontitis (healthy control), experimental periodontitis (EPD), EPD
treated with SRP alone (SRP), EPD treated with SRP+T (SRP+T), and EPD treated with
SRP+CU (SRP+CU). After 2 and 4 weeks of treatment, tissue samples were assessed by
hematoxylin and eo-sin, and special stains (Perls’ stain and Masson’s Trichrome)
for counting of inflammatory cells, angiogenesis, collagen fibers, and iron
deposition. Significant reductions in inflammatory cells in-filtration and alveolar
bone resorption with angiogenesis and collagen fibers deposition were de-tected
after 2 and 4 weeks in both SRP+T and SRP+CU groups. SRP+CU resulted in a
significant reduction in osteoclast numbers (week 2) and iron deposition (week 4)
in bone trabeculae as compared to SRP and SRP+T groups. The adjunctive use of CU
showed comparable results to T in the reduction in inflammation and bone
resorption. Furthermore, CU has potential osteogenesis and healing effects.
AN - rayyan-563559869
AU - Ali, K. M.
AU - Al‐rawi, R. A.
AU - Gul, S. S.
IS - 4
KW - cage
curette
microscope
microtome
needle
operating table
RM2135
syringe
2 propanol
curcumin
drinking water
eosin
formaldehyde
formic acid
hematoxylin
hydrochloric acid
iron
ketamine
paraffin
propylene glycol
purified water
sorbate potassium
tetracycline
xylene
alveolar bone
alveolar crest
angiogenesis
animal cell
animal experiment
animal model
animal tissue
article
biofilm
bone density
bone development
cell infiltration
cervical spine dislocation
collagen fiber
connective tissue
controlled study
cytoplasm
dental scaling
general anesthesia
gingiva
granulation tissue
healing
histology
histopathology
incisor
iron blood level
ligation
light dark cycle
lymphocyte count
macrophage
male
microscopy
neutrophil count
nonhuman
osteoclast
osteolysis
paraffin embedding
promoter region
rat
root planing
tissue section
LA - English
PY - 2022
SN - 2079-6382
ST - Effects of Curcumin and Tetracycline Gel on Experimental Induced
Periodontitis as an Anti‐Inflammatory, Osteogenesis Promoter and Enhanced Bone
T2 - Antibiotics
TI - Effects of Curcumin and Tetracycline Gel on Experimental Induced
Periodontitis as an Anti‐Inflammatory, Osteogenesis Promoter and Enhanced Bone
VL - 11
ID - 13243
ER -
TY - JOUR
AB - Disinfection of the root canal system is one of the primary aims of root
canal treatment. This can be achieved through the use of various antimicrobial
agents in the form of irrigants and medicaments. These agents are only used for
relatively short periods of time ranging from minutes (for irrigants) up to days or
several weeks (for medicaments) and therefore their long-term antimicrobial effects
rely on whether or not the particular agent has any properties of substantivity. If
irrigants and medicaments had effective long-term residual antimicrobial activity
that could prevent re-infection of the root canal system, then the long-term
outcomes of endodontic treatment might be improved. Only a small number of studies
have investigated the short-term substantivity of commonly used antimicrobial
agents and the results show substantivity of chlorhexidine lasts for up to 12 weeks
and tetracycline for up to 4 weeks. However, it is not known whether the
substantivity of these agents will last for longer periods of time as this has not
been investigated.
AN - rayyan-563562526
AU - Mohammadi, Z.
AU - Abbott, P. V.
DO - 10.1111/j.1747-4477.2009.00164.x
IS - 3
PY - 2009
SN - ["1329-1947", "1747-4477"]
SP - 131-139
ST - Antimicrobial substantivity of root canal irrigants and medicaments: A review
T2 - AUSTRALIAN ENDODONTIC JOURNAL
TI - Antimicrobial substantivity of root canal irrigants and medicaments: A review
VL - 35
Y2 - 12
ID - 15900
ER -
TY - JOUR
AB - The prevalence of periodontitis is around 20-50% in the global population. If
it is not treated, it can cause tooth loss. Periodontal treatment aims at
preserving the patient's teeth from various damages, including infection control
and restoring lost periodontal tissue. The periodonti-um has great biological
regenerative potential, and several biomaterials can be used to improve the outcome
of periodontal treatment. To achieve the goal of periodontal tissue regeneration,
numerous studies have used fibroblast growth factor 2 (FGF2) to stimulate the
regeneration of both the soft tissue and bone. FGF2 induced a significant increment
in the percentage of bone fill, bone mineral levels of the defect sites, length of
the regenerated periodontal ligament, angiogenesis, connective tissue formation on
the root surface, formation of dense fibers bound to the alveolar bone and newly
synthesized ce-mentum in teeth. This review will open further avenues to better
understand the FGF2 therapy for periodontal regeneration.
AN - rayyan-563560033
AU - Mohammadipour, H. S.
AU - Forouzanfar, F.
AU - Forouzanfar, A.
DO - 10.2174/1389450121999201105152639
IS - 3
calcium phosphate
chitosan
collagen gel
gelatinase B
hyaluronate synthetase
hyaluronic acid
hyaluronidase
hydrogel
inositol trisphosphate
interleukin 6
keratinocyte growth factor
osteocalcin
osteopontin
recombinant fibroblast growth factor
streptozocin
stromelysin
vasculotropin
alveolar bone
angiogenesis
biomineralization
bone defect
bone development
bone mineral
bone regeneration
cell survival
cementogenesis
connective tissue
DNA sequence
fibroblast
fracture healing
gene expression
hedgehog signaling
hippocampus
human
infection control
morphogenesis
nonhuman
ossification
periodontal disease
periodontitis
protein expression
review
sequence analysis
signal transduction
tissue regeneration
tooth cementum
umbilical vein endothelial cell
wound healing
LA - English
PY - 2021
SN - ["1873-5592", "1389-4501"]
SP - 310-317
ST - The role of type 2 fibroblast growth factor in periodontal therapy
T2 - Curr. Drug Targets
TI - The role of type 2 fibroblast growth factor in periodontal therapy
VL - 22
ID - 13407
ER -
TY - JOUR
AB - Complete regeneration of the periodontium is the aim of any successful
periodontal treatment. Recent Technologies have come up with many advances like
cell-based therapy, peptides, genetic transfer, scaffolds, bone anabolics, and
above all lasers. Four basic elements are required for periodontal repair and
regeneration that includes adequate blood supply and wound stability, a source of
bone and ligament forming cells, a supporting scaffold, and growth factors to
regulate cell migration, synthesis and angiogenesis for revascularization of the
site. The newer technologies not only offer unique opportunities but also enhance
the predictability of regenerative procedures.
AN - rayyan-563560087
AU - Mohanty, G.
AU - Mohanty, R.
AU - Kumar, M.
AU - Panda, S.
DO - 10.37506/ijfmt.v14i4.12987
IS - 4
KW - biomaterial
calcium phosphate
collagen
elastin
gelatin
growth factor
hydrogel
hydroxyapatite
molecular scaffold
polycaprolactone
polyglactin
polylactic acid
polymer
polyurethan
polyvinyl alcohol
vasculotropin
angiogenesis
article
autograft
biocompatibility
bone graft
bone remodeling
cell migration
cell proliferation
computer aided design/computer aided manufacturing
flexor tendon
gene transfer
human
osseointegration
periodontium
revascularization
thrombocyte aggregation
tissue engineering
tissue regeneration
LA - English
PY - 2020
SN - ["0973-9130", "0973-9122"]
SP - 8314-8321
ST - Tissue engineering and regeneration therapy: A boon for periodontal research
TI - Tissue engineering and regeneration therapy: A boon for periodontal research
VL - 14
ID - 13461
ER -
TY - JOUR
AB - Background and Aim: Adjunctive therapy may enhance the effect of periodontal
treatment with significant improvement of periodontal outcomes. Commercially
available locally delivered synthetic Antimicrobial Peptide (AMP) gel used as
locally-delivered antimicrobial agent has been reported to improve periodontal
treatment outcomes. This study aimed to investigate the expression of proteins and
cytokines following application of Ace Helper™ AMP gel as an adjunct to scaling and
root surface debridement in Stage III periodontitis patients. Methods: This was an
in vivo pilot study of a 3-month duration. Two subjects with Stage III
periodontitis were recruited. A randomised split-mouth design was employed to
assign the deep periodontal sites (n = 8) to test and control groups. Periodontal
parameters: periodontal pocket depth (PPD) and clinical attachment level (CAL) were
measured at baseline, 6 weeks and 12 weeks. Gingival crevicular fluid (GCF) were
sampled from teeth with PPD >6 mm using paper points at the same time points. Ace
Helper™ AMP gel was applied to the test sites following scaling and root surface
debridement. GCF samples were subjected to proteomic analysis using liquid
chromatography-mass spectrometry (LC-MS Orbitrap). Results: A total of 741 and 886
proteins were identified in the GCF samples representing test and control groups,
respectively. At 12-weeks, higher number of proteins related to biological
processes were found in the test group compared to the control group, however the
difference was not significant (p > 0.05). There were no significant differences in
the expressions of fibronectin (p > 0.05) and annexin A1 (p > 0.05) over the 12-
week follow-up. Conclusions: Within the limitation of the study, a trend of higher
protein expression related to the biological processes at periodontal sites treated
with adjunctive Ace Helper™ AMP gel was observed. This could suggest increased
healing activity and further studies are warranted to confirm these findings.
AN - rayyan-563559849
AU - Mohd Hanifah, M. H.
AU - Safii, S. H.
AU - Wan Ibrahim, W. I.
AU - Hussin, M. Z.
DO - 10.1111/jcpe.13636
cytokine
endogenous compound
fibronectin
lipocortin 1
adult
animal experiment
animal model
conference abstract
controlled study
debridement
female
follow up
gene expression
gingivitis
human
in vivo study
male
mass spectrometer
mouth
nonhuman
periodontitis
periodontium
pilot study
protein expression
LA - English
PY - 2022
SN - 1600-051X
SP - 173
ST - Expression of inflammatory and healing biomarkers following use of
antimicrobial peptide gel as an adjunct to scaling and root surface debridement: A
pilot study
TI - Expression of inflammatory and healing biomarkers following use of
antimicrobial peptide gel as an adjunct to scaling and root surface debridement: A
pilot study
VL - 49
ID - 13223
ER -
TY - JOUR
AB - A prophylactic surgical Operculectomy could be as a suitable alternative for
third molar extraction, but associate with some hemostatic complications. Recently,
Laser Assist Periodontal (LAP) technique like Operculectomy encounter theses
complications with some periodontal obliteration and hemostasis deterioration
intraoperatively and postoperatively. Remarkably, A regenerative use of Hyaluronic
Acid (HA) in different procedures fasten hemostasis and enhance fascinate healing
recovery. Initially, This report highlight proper clinical management of five cases
of 27 to 30 years old bot gender using diode laser 1064wl LAP Operculectomy with
unusual topical applied HA gel on site of operation were developed pericoronitis
around fully erupted buccally malposed wisdom mandibular teeth. Due to procedure
advantages and better patients respons toward to become a preferred option for
minor oral surgical procedures. Operculectomy by LAP procedure with HA adjunctive
application result in Proper incision, Ablation, Coagulation and fascinate tissue
remodeling postoperatively.
AN - rayyan-563560005
AU - Mohi, A.
IS - 1
KW - diode laser
diode laser 1064nm
analgesic agent
antibiotic agent
hyaluronic acid
adult
article
case report
clinical article
face pain
female
follow up
gingiva disease
gingivectomy
halitosis
hemostasis
human
human tissue
laser assisted operculectomy
lymphadenopathy
male
minimally invasive surgery
mouth hygiene
operculum congestion
pain
third molar
tissue injury
trismus
LA - English
PY - 2021
SN - ["0976-1772", "0972-5075"]
SP - 1085-1089
ST - Minimally Invasive Management using Laser Assisted operculectomy with
Adjunctive Hyaluronic Acid: a Case report
TI - Minimally Invasive Management using Laser Assisted operculectomy with
Adjunctive Hyaluronic Acid: a Case report
VL - 21
ID - 13379
ER -
TY - JOUR
AB - Plants are the only source of medicine and because of its properties, many
places uses herbal products than synthetic drugs. Synthetic drugs are sometimes
harmful and can cause side-effects in certain individuals. The objective of this
article is to review the efficacy of using curcumin in the treatment of periodontal
diseases and to highlight its pharmacological actions in dentistry. Turmeric is an
ancient dye and is a flavouring and medicinal herb which is widely used in Asian
countries. It is mostly known by its name because the herb is widely used in Indian
medicine, cookery and in cosmetics. Curcumin is the main component of
turmeric.Curcuma Longa has a number of medicinal properties and has been attributed
as a traditional medicine.It has proven to have anti-inflammatory, antimicrobial,
anti-oxidant properties and has a major role in periodontal diseases and oral
cancers unlike other plant medicines. The misuse and frequent use of differently
available therapeutic agents leads to the evolution of of increased prevalence of
side effects and develops resistant strains. They are commercially available and is
affordable and is easily used. These plant products are used in dentistry to
promote oral hygiene and to improve dental health. Our daily intake of consists of
foods containing sugar diet,bakery and carbonated drinks that increases the
prevalence of dental caries.Lack of maintaining proper oral hygiene can accumulate
plaque and calculus which is the main aetiology for developing gingivitis and
periodontitis. Since the oral cavity is said to be the mirror of illness in other
areas of the body and systemic diseases are being manifested in in the soft tissue
of the oral mucosa of the mouth. Hence overall health can be affected when oral
health is compromised.Therefore, traditional plants can treat bacterial infections
and are considered as a very good alternative to synthetic chemicals.
AN - rayyan-563560227
AU - Monisha, K.
AU - Ramamurthy, J.
IS - 5
KW - curcumin
gel
mouthwash
dentistry
diarrhea
drug efficacy
drug mechanism
drug safety
feces color
gingivitis
headache
human
nausea
nonhuman
periodontal disease
rash
review
side effect
tooth plaque
LA - English
PY - 2019
SN - 0975-7619
SP - 1130-1133
ST - Role of Curcumin in Periodontal disease - A Review
T2 - Drug Invent. Today
TI - Role of Curcumin in Periodontal disease - A Review
VL - 11
ID - 13601
ER -
TY - JOUR
AB - Background & Aim: Periodontitis is a dysbiotic chronic inflammatory age-
related disease of the periodontium, leading to the destruction of the tooth-
supporting tissues. At the present time, current therapies give insufficient and
unpredictable results, and long-term basis restoration of periodontal tissue
homeostasis leading to tissue regeneration remains a challenge. Given their
significant pro-angiogenic, anti-bacterial and immuno-modulatory capabilities,
adipose-derived stromal cells (ASCs) graft within a suitable vehicle, may be
proposed to achieve this aim. Methods, Results & Conclusion: 15 beagle dogs (mean
age 9.6 ± 2.5 years) with spontaneous periodontitis were included in a double-
blind split-mouth study with random affectation of the treatment per mandibular
side. After non- surgical periodontal treatment, mandibular periodontal lesions
were grafted with a platelet lysate-based hydrogel with or without autologous ASCs.
Clinical examination and X-rays were used to assess periodontal tissue loss
severity (periodontal pocket depth (PPD) and clinical attachment level (CAL)) and
inflammatory activity (bleeding on probing (BoP), gingival index (GI)) of
periodontal sites at 45 and 120 days after grafting. Histological analysis was also
carried at 120 days. RNA-sequencing (RNA-seq) was performed to identify ASC
expression profile and putative association with clinical outcomes. Although inter-
individual heterogeneity, all clinical parameters of both disease severity and
activity were improved at 120 days in ASC grafted sites compared to hydrogel alone
treated sites. The mean difference adjusted on the subject and the baseline value
(aMD [CI95%]) highlighted a significant clinical improvement at 120 days (PPD:-
1.24[-1.64;- 0.85]; p<0.001; CAL:-1.16[- 1.80;-0.53]; p<0.001; BoP: -0.60[-0.85;-
0.36]; p<0.001; GI: -0.37[- 0;52;-0.22]; p<0.001), confirmed by X-ray imaging data.
Microscopic analysis demonstrated more stabilized periodontium in ASC grafted sites
than controls. Finally, RNA-seq data pointed out different geneexpression profiles
related to CAL and BoP improvement. This double- blind randomized clinical trial
performed on spontaneous lesions developed in the older dog shows for the first
time autologous ASC therapy as relevant to induce a stable periodontal
regeneration, thus opening opportunities for innovative regenerative periodontal
therapies
AN - rayyan-563559858
AU - Monsarrat, P.
AU - Laurencin-Dalicieux, S.
AU - Blasco-Baque, V.
AU - Jourdan, G.
AU - Bouhsira, E.
AU - Casteilla, L.
AU - Raymond-Letron, I.
AU - Kemoun, P.
AU - Planat, V.
DO - 10.1016/S1465-3249(22)00160-8
IS - 5
hydrogel
animal cell
animal experiment
animal model
animal tissue
beagle
bleeding on probing
canine model
cell therapy
clinical outcome
conference abstract
controlled study
dog
drug combination
gene expression
gingival index
histology
human
implantation
inflammation
mandible
mouth
nonhuman
outcome assessment
periodontitis
periodontium
preclinical study
radiography
regeneration
RNA sequencing
stroma cell
thrombocyte
LA - English
PY - 2022
SN - ["1477-2566", "1465-3249"]
SP - S43-S44
ST - Mesenchymal Stem/Stromal Cells: PERIODONTITIS THERAPY USING COMBINED
IMPLANTATION OF AUTOLOGOUS ADIPOSE-DERIVED STROMAL CELLS AND PLATELET LYSATE-BASED
HYDROGEL: A DOUBLE-BLIND RANDOMIZED CONTROLLED PRECLINICAL STUDY IN A SPONTANEOUS
CANINE MODEL
T2 - Cytotherapy
TI - Mesenchymal Stem/Stromal Cells: PERIODONTITIS THERAPY USING COMBINED
IMPLANTATION OF AUTOLOGOUS ADIPOSE-DERIVED STROMAL CELLS AND PLATELET LYSATE-BASED
HYDROGEL: A DOUBLE-BLIND RANDOMIZED CONTROLLED PRECLINICAL STUDY IN A SPONTANEOUS
CANINE MODEL
VL - 24
ID - 13232
ER -
TY - JOUR
AB - To evaluate the efficacy of metronidazole on cyclosporine-induced gingival
overgrowth (GO), a prospective intra-subject double-blind longitudinal study was
performed on six heart transplant patients with GO. All patients underwent scaling
and root planing before any treatment. Metronidazole gel (Elyzol, Cabon) was then
applied in two of the four anterior hemi-sextants of each subject, following a
balanced random pre-programmed list, with a placebo gel being applied to the
remaining two hemi-sextants. Plaque index (PI), bleeding on probing (BP) and
probing depth (PD) were recorded for all teeth of the four anterior hemi-sextants
before and at 1, 2, 3, and 4 months after gel application. A general linear model
was fitted and ANOVA for repeated measurements with split-plot design and Chi-
square analysis were used for statistical analysis. PD significantly decreased
after 1 month following both treatments. Analogous results were obtained as regards
PI and BP. No statistically significant difference was detected between results
obtained with metronidazole and placebo. However, PD in the group of teeth treated
with placebo significantly increased after 4 months, while PD values obtained from
teeth treated with metronidazole remained statistically unchanged with respect to
the 1st month. In conclusion, short-term results suggest that metronidazole and
placebo are equally effective in reducing periodontal parameters and GO when
associated with scaling and root planing. Long-term results, however, showed
greater efficacy of metronidazole with respect to placebo in controlling
cyclosporine-induced GO.
AN - rayyan-563560913
AU - Montebugnoli, L.
AU - Servidio, D.
AU - Prati, C.
DO - 10.1007/s00784-001-0142-3
IS - 1
cyclosporine
metronidazole
placebo
article
clinical trial
controlled study
female
follow up
gel
gingiva bleeding
gingiva overgrowth
heart transplantation
human
longitudinal study
male
middle aged
periodontitis
prospective study
statistical model
tooth plaque
treatment outcome
LA - English
PY - 2002
SN - 1432-6981
SP - 24-27
ST - Effectiveness of metronidazole gel on cyclosporine-induced gingival
overgrowth in heart transplant patients
TI - Effectiveness of metronidazole gel on cyclosporine-induced gingival
overgrowth in heart transplant patients
VL - 6
ID - 14287
ER -
TY - JOUR
AB - P>1. Chlorhexidine digluconate has been used as a topical antiseptic in the
treatment of acne vulgaris and periodontitis. The acute phase of these diseases
involves neutrophilic infiltration. Neutrophil activation and recruitment to
inflammatory sites are crucial in both protection against bacterial infection and
the induction of hystotoxic damage. Activated neutrophils release several enzymes,
including elastase and myeloperoxidase (MPO), which contribute to tissue injury via
direct toxic actions, the generation of oxidants and inactivation of protective
factors, such as alpha 1-antitrypsin (alpha 1-AT). In the present study, we
investigated whether chlorhexidine can modulate neutrophil-mediated histotoxicity.
2. Human primary neutrophils were isolated from healthy donors. Inactivation of
alpha 1-AT by neutrophils or hypochlorous acid (HOCl) was evaluated by
spectrophotometry and sodium dodecyl sulphate-polyacrylamide gel electrophoresis
analysis of its capacity to complex with porcine pancreatic elastase (PPE).
Neutrophil generation of HOCl, superoxide anion and MPO release were assessed
spectrophometrically. 3. Chlorhexidine (0, 0.5, 1, 5 and 10 mu mol/L) dose-
dependently prevented HOCl-induced inactivation of alpha 1-AT and reduced HOCl
recovery from phorbol myristate acetate (PMA)-treated human neutrophils, but did
not inhibit superoxide anion and MPO release. Chlorhexidine directly inhibited HOCl
recovery from neutrophils and HOCl-induced inactivation of alpha 1-AT in a cell-
free assay. Accordingly, chlorhexidine reversed HOCl-mediated inhibition of alpha
1-AT capacity to complex with PPE. 4. These data suggest that chlorhexidine
prevents neutrophil-induced alpha 1-AT inactivation via a direct inhibitory action
on HOCl. Although highly speculative, the present study indicates that
chlorhexidine may protect inflamed tissues not only through its antimicrobial
properties, but also via a direct anti-inflammatory effect on neutrophil toxic
products.
AN - rayyan-563562538
AU - Montecucco, F.
AU - Bertolotto, M.
AU - Ottonello, L.
AU - Pende, A.
AU - Dapino, P.
AU - Quercioli, A.
AU - Mach, F.
AU - Dallegri, F.
DO - 10.1111/j.1440-1681.2009.05270.x
IS - 11
PY - 2009
SN - 1440-1681
SP - e72-e77
ST - Chlorhexidine prevents hypochlorous acid-induced inactivation of alpha 1-
antitrypsin
T2 - CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
TI - Chlorhexidine prevents hypochlorous acid-induced inactivation of alpha 1-
antitrypsin
VL - 36
Y2 - 11
ID - 15912
ER -
TY - JOUR
AB - 1. Chlorhexidine digluconate has been used as a topical antiseptic in the
factors, such as alpha1-antitrypsin (alpha1-AT). In the present study, we
investigated whether chlorhexidine can modulate neutrophil-mediated histotoxicity.
2. Human primary neutrophils were isolated from healthy donors. Inactivation of
alpha1-AT by neutrophils or hypochlorous acid (HOCl) was evaluated by
spectrophotometry and sodium dodecyl sulphate-polyacrylamide gel electrophoresis
analysis of its capacity to complex with porcine pancreatic elastase (PPE).
Neutrophil generation of HOCl, superoxide anion and MPO release were assessed
spectrophometrically. 3. Chlorhexidine (0, 0.5, 1, 5 and 10 micromol/L) dose-
dependently prevented HOCl-induced inactivation of alpha1-AT and reduced HOCl
recovery from phorbol myristate acetate (PMA)-treated human neutrophils, but did
not inhibit superoxide anion and MPO release. Chlorhexidine directly inhibited HOCl
recovery from neutrophils and HOCl-induced inactivation of alpha1-AT in a cell-free
assay. Accordingly, chlorhexidine reversed HOCl-mediated inhibition of alpha1-AT
capacity to complex with PPE. 4. These data suggest that chlorhexidine prevents
neutrophil-induced alpha1-AT inactivation via a direct inhibitory action on HOCl.
Although highly speculative, the present study indicates that chlorhexidine may
protect inflamed tissues not only through its antimicrobial properties, but also
via a direct anti-inflammatory effect on neutrophil toxic products.
AN - rayyan-563561380
AU - Montecucco, F.
AU - Bertolotto, M.
AU - Ottonello, L.
AU - Pende, A.
AU - Dapino, P.
AU - Quercioli, A.
AU - Mach, F.
AU - Dallegri, F.
DO - 10.1111/j.1440-1681.2009.05270.x
IS - 11
J2 - Clin Exp Pharmacol Physiol
KW - Anti-Inflammatory Agents/*pharmacology
Cells, Cultured
Chlorhexidine/*analogs & derivatives/pharmacology
Enzyme Inhibitors/pharmacology
Humans
Hypochlorous Acid/antagonists & inhibitors/metabolism/pharmacology
Models, Immunological
Neutrophil Activation/*drug effects
Neutrophils/*drug effects/enzymology/metabolism
Peroxidase/metabolism
Superoxides/metabolism
Tetradecanoylphorbol Acetate/pharmacology
alpha 1-Antitrypsin/*metabolism
LA - eng
N1 - Division of Cardiology, Foundation for Medical Researches, Department of
Medicine, Geneva University Hospital, Geneva, Switzerland.
fabrizio.montecucco@unige.ch
PY - 2009
SP - e72-7
ST - Chlorhexidine prevents hypochlorous acid-induced inactivation of alpha1-
antitrypsin
T2 - Clinical and experimental pharmacology & physiology
TI - Chlorhexidine prevents hypochlorous acid-induced inactivation of alpha1-
antitrypsin
VL - 36
Y2 - 11
ID - 14754
ER -
TY - JOUR
AB - 1. Chlorhexidine digluconate has been used as a topical antiseptic in the
factors, such as α1-antitrypsin (α1-AT). In the present study, we investigated
whether chlorhexidine can modulate neutrophil-mediated histotoxicity. 2. Human
primary neutrophils were isolated from healthy donors. Inactivation of α1-AT by
neutrophils or hypochlorous acid (HOCl) was evaluated by spectrophotometry and
sodium dodecyl sulphate-polyacrylamide gel electrophoresis analysis of its capacity
to complex with porcine pancreatic elastase (PPE). Neutrophil generation of HOCl,
superoxide anion and MPO release were assessed spectrophometrically. 3.
Chlorhexidine (0, 0.5, 1, 5 and 10 μmol/L) dose-dependently prevented HOCl-induced
inactivation of α1-AT and reduced HOCl recovery from phorbol myristate acetate
(PMA)-treated human neutrophils, but did not inhibit superoxide anion and MPO
release. Chlorhexidine directly inhibited HOCl recovery from neutrophils and HOCl-
induced inactivation of α1-AT in a cell-free assay. Accordingly, chlorhexidine
reversed HOCl-mediated inhibition of α1-AT capacity to complex with PPE. 4. These
data suggest that chlorhexidine prevents neutrophil-induced α1-AT inactivation via
a direct inhibitory action on HOCl. Although highly speculative, the present study
indicates that chlorhexidine may protect inflamed tissues not only through its
antimicrobial properties, but also via a direct anti-inflammatory effect on
neutrophil toxic products. © 2009 Blackwell Publishing Asia Pty Ltd.
AN - rayyan-563560660
AU - Montecucco, F.
AU - Bertolotto, M.
AU - Ottonello, L.
AU - Pende, A.
AU - Dapino, P.
AU - Quercioli, A.
AU - MacH, F.
AU - Dallegri, F.
DO - 10.1111/j.1440-1681.2009.05270.x
IS - 11
hypochlorous acid
myeloperoxidase
pancreatic elastase
phorbol 13 acetate 12 myristate
superoxide
article
cell assay
cell isolation
controlled study
enzyme release
human
human cell
leukocyte activation
neutrophil
normal human
periodontitis
spectrophotometry
toxicity
LA - English
PY - 2009
SN - ["0305-1870", "1440-1681"]
SP - e72-e77
ST - Chlorhexidine prevents hypochlorous acid-induced inactivation of α1-
antitrypsin
T2 - Clin. Exp. Pharmacol. Physiol.
TI - Chlorhexidine prevents hypochlorous acid-induced inactivation of α1-
antitrypsin
VL - 36
ID - 14034
ER -
TY - JOUR
AB - Background Periodontal disease, is a public health problem affecting 60-90%
of the world adult population. The destructive stage is characterized by gingival
inflammation, clinical attachment loss, and the formation of periodontal pockets
between the gums and teeth. Gram-negative bacteria can produce chronic infections
by attaching themselves and growing on the surface of periodontal tissue. They
respond poorly to antibiotic treatment and cannot be prevented by
immunization.1,2,3,4,5 Research has provided insights into metabolic elements of
the host that are implicated in this disease. Homeopathy utilizes small doses of
diverse substances to stimulate the processes of the body to cure and regulate
itself.7 It is a medical approach based on the Law of Similarity.8 If a substance
produces a series of signs and symptoms in a healthy individual, it is capable of
curing similar symptoms in a patient. For periodontal disease, Mercurius solubilis
Hg2 (NO3)2) was selected. Objective To evaluate the effect of Mercurius solubilis
12c administered orally during the treatment of patients with periodontitis, based
on quantification of the matrix metalloproteinases (MMPs) in saliva by the
immunoblot technique. Materials and Methods This was a random, double-blind
clinical trial with two modes of treatment: Mercurius solubilis and placebo.
Inclusion criteria were relapse of periodontal disease and the signing of informed
consent. A health questionnaire was applied to each participant, as well as a
clinical exploration using standards established by the World Workshop on Clinical
Periodontology. Each patient was instructed on the proper techniques for brushing
his/her teeth and controlling plaque, as well as the use of hygiene aids.13,14
Saliva was obtained (unstimulated) and stored at -70 °C. The quantification of
total proteins in saliva was carried out by the Lowry method, and the separation of
proteins by electrophoresis (SDS Page), with the specificity of immunochemical
recognition of MMPs and control of the charge of β actin. Quantity (Version 4.1,
Biorad) software was used for statistical analysis, applying two-way ANOVA
(p<0.05). Results Patients completely adhered to the combined treatment. No adverse
effects have been reported during treatment with Mercurius solubilis. The
diagnostic probe and posterior reassessment was carried out by a blinded
professional. A decrease was found in the depth of the periodontal pockets of both
treatment groups. MMP-8 expression decreased in both groups after 3-week
treatments. No differences between groups have been identified in the interim
analysis. Discussion The treatment of periodontal disease requires the combination
of dental, surgical and pharmacological procedures. The selection of beta-lactam
antibiotics to treat this condition is based on epidemiological criteria in
function of the clinical assessment. These antibiotics are only effective against
some Gram-negative bacteria and produce a high proportion of adverse effects. The
use of alternative therapy, such as homeopathy, allows the doctor to consider
mental and physical aspects of the disease, thus contributing to the total recovery
of oral hygiene. Conclusion and patients have made note of the benefits of the easy
administration and innocuousness. Additionally, this homeopathic therapy for
patients with periodontal disease is safe and effective.
AN - rayyan-563560302
AU - Monterde-Coronel, M. E.
AU - Asbun-Bojalil, J.
AU - Hernández-Campos, M. E.
AU - Lopez-Sánchez, P.
AU - Aguilar-Faisal, J. L.
IS - 1
beta actin
endogenous compound
placebo
protein
unclassified drug
alternative medicine
antibiotic therapy
clinical study
clinical trial
controlled study
drug combination
female
homeopathy
human
immunization
immunoblotting
informed consent
low drug dose
male
molecular recognition
mouth hygiene
nonhuman
normal human
periodontal pocket
periodontics
quantitative study
questionnaire
relapse
remission
saliva
software
surgery
symptom
LA - English
PY - 2017
SN - 1530-6860
ST - The efficacy of Mercurius solubilis, an homeopathic medication, for the
T2 - FASEB J.
TI - The efficacy of Mercurius solubilis, an homeopathic medication, for the
VL - 31
ID - 13676
ER -
TY - JOUR
AB - Successful disinfection alongside complete endodontic tissue regeneration and
revascularization are the most desired clinical outcomes of regenerative
endodontics. Despite reported clinical successes, significant limitations to the
current regenerative endodontic procedure (REP) have been elucidated. To improve
the current REP, an antibiotics and nitric oxide (NO) releasing biomimetic
nanomatrix gel was developed. The study evaluates antibacterial effects of an
antibiotics and NO releasing biomimetic nanomatrix gel on multispecies endodontic
bacteria. Antibiotics, ciprofloxacin (CF) and metronidazole (MN) were mixed and
encapsulated within the NO releasing biomimetic nanomatrix gel. The gel was
synthesized and self-assembled from peptide amphiphiles containing various
functional groups. Antibacterial effects of the antibiotics and NO releasing
biomimetic nanomatrix gel were evaluated using bacterial viability assays involving
endodontic microorganisms including clinical samples. Pulp-dentin regeneration was
evaluated via animal-model experiments. The antibiotics and NO releasing biomimetic
nanomatrix gel demonstrated a concentration dependent antibacterial effect. In
addition, NO alone demonstrated a concentration dependent antibacterial effect on
endodontic microorganism. An in vivo analysis demonstrated the antibiotics and NO
releasing biomimetic nanomatrix gel promoted tooth revascularization with
maturation of root canals. An optimal concentration of and NO releasing nanomatrix
gel is suggested for its potential as a root treatment material for REP and an
appropriate protocol for human trials. Further investigation is required to obtain
a larger sample size and decide upon ideal growth factor incorporation.
AN - rayyan-563562485
AU - Moon, C. Y.
AU - Nam, O. H.
AU - Kim, M.
AU - Lee, H. S.
AU - Kaushik, S. N.
AU - Walma, D. A. C.
AU - Jun, H. W.
AU - Cheon, K.
AU - Choi, S. C.
DO - 10.1371/journal.pone.0205534
IS - 10
PY - 2018
SN - 1932-6203
ST - Effects of the nitric oxide releasing biomimetic nanomatrix gel on pulp-
dentin regeneration: Pilot study
T2 - PLOS ONE
TI - Effects of the nitric oxide releasing biomimetic nanomatrix gel on pulp-
dentin regeneration: Pilot study
VL - 13
Y2 - 10 y3 - 11
ID - 15859
ER -
TY - JOUR
AB - Barrier membranes are used in periodontal tissue engineering for successful
neo-bone tissue formation and prevention of bacterial colonization. We aimed to
prepare and characterize novel 7% boron-modified bioactive glass (7B-BG) containing
bilayered membrane for this end. We hypothesized that presence of 7B-BG could
promote structural and biological properties of guided bone regeneration (GBR)
membrane. Cellulose acetate (CA) layer was prepared by solvent casting, and
functionally graded layer of CA/gelatin/BG nanoparticles was prepared by
electrospinning. 0B-BG, and 7B-BG were synthesized by quick alkali-mediated sol–gel
method and were characterized by scanning electron microscopy (SEM) and Fourier-
transform Raman spectroscopy. Membranes were cross-linked with glutaraldehyde to
preserve their stability. SEM analysis showed the asymmetric nature of membranes
consisting of a smooth membrane layer and a rough surface composed of 0B-BG and 7B-
BG containing nanofibres. 7B-BG addition increased surface wettability (from 110.5°
± 0.8 to 73.46° ± 7.6) and biodegradability of the membranes. Additionally, a
significant increase in Ca–P layer formation was observed in 7B-BG containing group
after 1-week incubation in stimulated body fluid. 7B-BG incorporation resulted in a
decrease in tensile strength and Young's modulus values. Human dental pulp stem
cells showed better attachment, spreading, and proliferation on 7B-BG containing
bilayered membranes. Osteogenic differentiation analysis revealed higher alkaline
phosphatase (ALP) enzyme activity of cells (~1.5-fold), higher intracellular
calcium deposition (approximately twofold), and higher calcium deposition revealed
by Alizarin red staining on 7B-BG containing bilayered membranes. Overall, results
suggested that functionally graded bilayered membranes hold potential for GBR
applications in regenerative dentistry.
AN - rayyan-563560182
AU - Moonesi Rad, R.
AU - Atila, D.
AU - Evis, Z.
AU - Keskin, D.
AU - Tezcaner, A.
DO - 10.1002/term.2877
IS - 8
boron
boron modified bioactive glass nanoparticle
cellulose acetate
glass
glutaraldehyde
nanoparticle
unclassified drug
article
bilayer membrane
biodegradability
bone mineralization
bone regeneration
calcium cell level
cell adhesion
cell proliferation
cell spreading
cell structure
cell viability
contact angle
controlled study
cross linking
crystallization
electrospinning
enzyme activity
Fourier transform spectroscopy
human
human cell
in vitro study
membrane stabilization
membrane structure
osteoblast
priority journal
Raman spectrometry
synthesis
tensile strength
wettability
Young modulus
LA - English
PY - 2019
SN - ["1932-7005", "1932-6254"]
SP - 1331-1345
ST - Development of a novel functionally graded membrane containing boron-modified
bioactive glass nanoparticles for guided bone regeneration
T2 - J. Tissue Eng. Regen. Med.
TI - Development of a novel functionally graded membrane containing boron-modified
bioactive glass nanoparticles for guided bone regeneration
VL - 13
ID - 13556
ER -
TY - JOUR
AB - The subgingival microflora of 39 HIV + subjects with gingivitis or adult
periodontitis was cultured quantitatively anaerobically for bacteria, spirochetes,
and mycoplasma and aerobically for yeasts. Isolates were characterized by
conventional biochemical tests, polyacrylamide gel electrophoresis of soluble
proteins, cellular fatty acid profiles, immunofluorescence, and immunodiffusion. In
general, the same types of bacteria were isolated from the subgingival crevice of
HIV + subjects as we previously had isolated from the subgingival crevice of non-
HIV subjects. A statistically significant difference was found between the
composition of the flora of HIV + subjects with adult periodonitis (AP) and
concurrent studies of a non-HIV + AP population. Mycoplasma salivarium was
significantly elevated in the HIV+ subjects examined. Yeasts were isolated from
only 10% of the samples and from 13% of the HIV-positive subjects as 0.05 to
0.0002% of the total cultivable count when present.
AN - rayyan-563561141
AU - Moore, L. V. H.
AU - Moore, W. E. C.
AU - Riley, C.
AU - Brooks, C. N.
AU - Burmeister, J. A.
AU - Smibert, R. M.
DO - 10.1902/jop.1993.64.1.48
IS - 1
KW - aciclovir
alpha interferon
didanosine
zidovudine
adult
article
clinical article
female
gingivitis
human
male
periodontitis
LA - English
PY - 1993
SN - 0022-3492
SP - 48-56
ST - Periodontal microflora of HIV positive subjects with gingivitis or adult
periodontitis
TI - Periodontal microflora of HIV positive subjects with gingivitis or adult
periodontitis
VL - 64
ID - 14515
ER -
TY - JOUR
AB - Nanotechnology is an emerging field of science, engineering, and technology
concerning the materials in nanoscale dimensions. Several materials are used in
dentistry, which can be modified by applying nanotechnology. Nanotechnology has
various applications in dentistry to achieve reliable treatment outcomes. The most
common nanometals used in dental materials are gold, silver, copper oxide,
magnesium oxide, iron oxide, cerium oxide, aluminum oxide, titanium dioxide, and
zinc oxide (ZnO). ZnO nanoparticles (NPs), with their unparalleled properties such
as high selectivity, enhanced cytotoxicity, biocompatibility, and easy synthesis as
important materials were utilized in the field of dentistry. With this background,
the present review aimed to discuss the current progress and gain an insight into
applications of ZnO NPs in nanodentistry, including restorative, endodontic,
implantology, periodontal, prosthodontics, and orthodontics fields.
AN - rayyan-563562624
AU - Moradpoor, H.
AU - Safaei, M.
AU - Mozaffari, H. R.
AU - Sharifi, R.
AU - Imani, M. M.
AU - Golshah, A.
AU - Bashardoust, N.
DO - 10.1039/d0ra10789a
IS - 34
PY - 2021
SN - 2046-2069
SP - 21189-21206
ST - An overview of recent progress in dental applications of zinc oxide
nanoparticles
T2 - RSC ADVANCES
TI - An overview of recent progress in dental applications of zinc oxide
nanoparticles
VL - 11
Y2 - 6 y3 - 23
ID - 15998
ER -
TY - JOUR
AB - Both past and presently available toothpastes contain potential antimicrobial
agents which could have a beneficial effect in the prevention of plaque and
gingivitis. If these preparations were to be effective clinically, some effect on
salivary bacteria would also be expected. This cross-over study measured salivary
bacterial counts and the presence or absence of residual antibacterial activity in
saliva following tooth brushing with 7 commercially available toothpastes, and
moreover, compared their effect with that produced by a chlorhexidine gel.
Generally, all toothpaste products produced a reduction in aerobic, anaerobic and
streptococcal counts with a hexetidine containing toothpaste producing the largest
and longest lasting reduction. In contrast, an enzyme containing toothpaste and an
amine fluoride toothpaste, had little effect on bacterial counts. The chlorhexidine
gel produced the largest reduction in salivary counts, which was evident for at
least 5 h following brushing. Residual antibacterial activity in saliva was only
evident immediately following brushing with the hexetidine toothpaste, but for the
chlorhexidine gel, was present up to 90 min following brushing. The findings of
this study have illustrated the limited antibacterial activity of presently
available toothpastes on the salivary flora compared to chlorhexidine, and as such,
would tend to question the relative benefit of toothpaste in preventing periodontal
disease through an antimicrobial effect.
AN - rayyan-563561319
AU - Moran, J.
AU - Addy, M.
AU - Newcombe, R.
DO - 10.1111/j.1600-051x.1988.tb01569.x
IS - 3
KW - Adult
Chlorhexidine/pharmacology
Clinical Trials as Topic
Dental Plaque/drug therapy
Dentifrices/*pharmacology
Female
Fluorides/pharmacology
Humans
Male
Prevotella melaninogenica/drug effects
Saliva/*microbiology
Time Factors
Toothpastes/*pharmacology
LA - eng
N1 - Department of Periodontology, University of Wales College of Medicine, Heath
Park, Cardiff, UK.
PY - 1988
SN - 0303-6979 (Print)
SP - 193-9
ST - The antibacterial effect of toothpastes on the salivary flora
TI - The antibacterial effect of toothpastes on the salivary flora
VL - 15
Y2 - 3
ID - 14693
ER -
TY - JOUR
AB - The objective of the present study is to evaluate Polyethylene sebacate (PES)
for its toxicity profile including oral toxicity, genotoxicity and mutagenicity.
PES was synthesised, and characterised by gel permeation chromatography, FTIR, 1H-
NMR, differential scanning calorimetry and X-ray diffraction. Oral toxicity studies
revealed PES to be nontoxic up to 3000 mg/kg body weight with no significant
changes in serum biochemistry. The standard battery of genotoxicity tests including
micronucleus test, chromosomal aberration and comet assay revealed PES as
nongenotoxic. Mutagenicity of PES was evaluated using the Ames microplate format
mutagenicity assay sample kit using TA98 and TA100 strains of Salmonella
typhimurium, both in presence and absence of Aroclor 1254 induced rat liver S9.
Ames assay confirmed PES to be non-mutagenic. Periodontal implants of PES of
varying roxithromycin/PES ratios and different diameter were prepared. A decrease
in in vitro drug release was seen with increase in diameter of the implants.
Release rates, however, increased with increase in PES concentration, and were
attributed to decreased crystallinity of roxithromycin, confirmed by the DSC
thermographs and XRD spectra. Roxithromycin release from the implants followed
Higuchi kinetics and exhibited controlled release. The results suggest PES as a
safe polymer for biomedical and pharmaceutical applications. © 2009 Wiley-Liss,
Inc. and the American Pharmacists Association.
AN - rayyan-563560656
AU - More, A. B.
AU - Chilgunde, S. N.
AU - Kamble, J. C.
AU - Patil, P. S.
AU - Malshe, V. C.
AU - Vanage, G. R.
AU - Devarajan, P. V.
DO - 10.1002/jps.21796
IS - 12
KW - aroclor 1254
biological marker
cyclophosphamide
macrogol 400
polyethylene sebacate
roxithromycin
unclassified drug
Ames test
animal experiment
article
chromosome aberration
comet assay
controlled study
DNA damage
drug release
drug synthesis
female
genotoxicity
male
micronucleus test
mutagenicity
nonhuman
periodontic device
rat
X ray diffraction
LA - English
PY - 2009
SN - ["0022-3549", "1520-6017"]
SP - 4781-4795
ST - Polyethylene sebacate: Genotoxicity, mutagenicity evaluation and application
in periodontal drug delivery system
T2 - J. Pharm. Sci.
TI - Polyethylene sebacate: Genotoxicity, mutagenicity evaluation and application
in periodontal drug delivery system
VL - 98
ID - 14030
ER -
TY - JOUR
AB - Periodontitis treatments usually require local administration of
antimicrobial drugs with the aim to reduce the bacterial load inside the
periodontal pocket. Effective pharmaceutical treatments may require sustained local
drug release for several days in the site of interest. Currently available
solutions are still not able to fulfill the clinical need for high-quality
treatments, mainly in terms of release profiles and patients' comfort. This work
aims to fill this gap through the development of an in situ gelling system, capable
to achieve controlled and sustained release of antimicrobial agents for medium-to-
long-term treatments. The system is composed of micrometer-sized β-cyclodextrin-
based hydrogel (bCD-Jef-MPs), featured by a strong hydrophilic character, suspended
in a synthetic block-co-polymer solution (Poloxamer 407), which is capable to
undergo rapid thermally induced sol–gel phase transition at body temperature. The
chemical structure of bCD-Jef-MPs was confirmed by cross-correlating data from
Fourier transform infrared (FTIR) spectroscopy, swelling test, and degradation
kinetics. The thermally induced sol–gel phase transition is demonstrated by
rheometric tests. The effectiveness of the described system to achieve sustained
release of antimicrobial agents is demonstrated in vitro, using chlorhexidine
digluconate as a drug model. The results achieved in this work disclose the
potential of the mentioned system in effectively treating periodontitis lesions.
(Figure presented.).
AN - rayyan-563560292
AU - Morelli, L.
AU - Cappelluti, M. A.
AU - Ricotti, L.
AU - Lenardi, C.
AU - Gerges, I.
DO - 10.1002/mabi.201700103
IS - 8
KW - beta cyclodextrin
poloxamer
article
biocompatibility
chemical structure
controlled study
cytotoxicity
drug formulation
gel
hydrogel
in vitro study
model
particle size
periodontal pocket
phase transition
temperature measurement
viscosity
wettability
LA - English
PY - 2017
SN - ["1616-5195", "1616-5187"]
ST - An Injectable System for Local and Sustained Release of Antimicrobial Agents
in the Periodontal Pocket
T2 - Macromol. Biosci.
TI - An Injectable System for Local and Sustained Release of Antimicrobial Agents
in the Periodontal Pocket
VL - 17
ID - 13666
ER -
TY - JOUR
AB - Periodontal diseases and dental caries are the most common infectious oral
diseases impacting oral health globally. Oral cavity health is crucial for
enhancing life quality since it serves as the entranceway to general health. The
oral microbiome and oral infectious diseases are strongly correlated. Gram-negative
anaerobic bacteria have been associated with periodontal diseases. Due to the
shortcomings of several antimicrobial medications frequently applied in dentistry,
the lack of resources in developing countries, the prevalence of oral inflammatory
conditions, and the rise in bacterial antibiotic resistance, there is a need for
reliable, efficient, and affordable alternative solutions for the prevention and
treatment of periodontal diseases. Several accessible chemical agents can alter the
oral microbiota, although these substances also have unfavorable symptoms such as
vomiting, diarrhea, and tooth discoloration. Natural phytochemicals generated from
plants that have historically been used as medicines are categorized as prospective
alternatives due to the ongoing quest for substitute products. This review
concentrated on phytochemicals or herbal extracts that impact periodontal diseases
by decreasing the formation of dental biofilms and plaques, preventing the
proliferation of oral pathogens, and inhibiting bacterial adhesion to surfaces.
Investigations examining the effectiveness and safety of plant-based medicines have
also been presented, including those conducted over the past decade.
AN - rayyan-563562300
AU - Mosaddad, S. A.
AU - Hussain, A.
AU - Tebyaniyan, H.
DO - 10.3390/microorganisms11051269
IS - 5
PY - 2023
SN - 2076-2607
ST - Green Alternatives as Antimicrobial Agents in Mitigating Periodontal
Diseases: A Narrative Review
T2 - MICROORGANISMS
TI - Green Alternatives as Antimicrobial Agents in Mitigating Periodontal
Diseases: A Narrative Review
VL - 11
Y2 - 5 y3 - 11
ID - 15674
ER -
TY - JOUR
AB - Reactive oxygen species (ROS) overproduction and oxidative stress are
increasingly being implicated in the extracellular matrix (ECM) degradation
associated with chronic inflammatory conditions, such as periodontal diseases. The
present study investigated the effects of ROS exposure on the proteoglycans of
gingival tissues, utilizing an in vitro model system comprised of supra-
physiological oxidant concentrations, to ascertain whether gingival proteoglycan
modification and degradation by ROS contributed to the underlying mechanisms of ECM
destruction during active gingivitis. Proteoglycans were purified from ovine
gingival tissues and exposed to increasing H2O2 concentrations or a hydroxyl
radical (·OH) flux for 1 h or 24 h, and ROS effects on proteoglycan core proteins
and sulfated glycosaminoglycan (GAG) chains were assessed. ROS were capable of
degrading gingival proteoglycans, with ·OH species inducing greater degradative
effects than H2O2 alone. Degradative effects were particularly manifested as amino
acid modification, core protein cleavage, and GAG chain depolymerization.
Proteoglycan core proteins were more susceptible to degradation than GAG chains
with H2O2 alone, although core proteins and GAG chains were both extensively
degraded by ·OH species. Proteoglycan exposure to ·OH species for 24 h induced
significant core protein amino acid modification, with decreases in glutamate,
proline, isoleucine, and leucine; and concomitant increases in serine, glycine, and
alanine residues. As clinical reports have previously highlighted proteoglycan core
protein degradation during chronic gingivitis, whereas their sulfated GAG chains
remain relatively intact, these findings potentially provide further evidence to
implicate ROS in the pathogenesis of active gingivitis, complementing the enzymic
mechanisms of periodontal tissue destruction already established.
AN - rayyan-563560049
AU - Moseley, R.
AU - Waddington, R. J.
DO - 10.1080/10715762.2021.2003351
IS - 9
KW - alanine
amino acid
arginine
aspartic acid
cellulose acetate
chondroitin sulfate
core protein
cysteine
dermatan sulfate
glutamic acid
glycine
glycosaminoglycan polysulfate
heparan sulfate
hexuronic acid
histidine
hydrogen peroxide
hydroxyl radical
isoleucine
leucine
lysine
methionine
phenylalanine
proline
proteoglycan
serine
thiourea
threonine
tryptophan
tyrosine
valine
amino acid analysis
animal experiment
animal model
animal tissue
anion exchange chromatography
article
cellulose acetate electrophoresis
comparative study
controlled study
degradation
depolymerization
electrophoresis
elution
gingival tissue
gingivitis
in vitro study
molecular size
molecular weight
nonhuman
periodontal disease
protein degradation
LA - English
PY - 2021
SN - ["1029-2470", "1071-5762"]
SP - 970-981
ST - Modification of gingival proteoglycans by reactive oxygen species: potential
mechanism of proteoglycan degradation during periodontal diseases
T2 - Free Radic. Res.
TI - Modification of gingival proteoglycans by reactive oxygen species: potential
mechanism of proteoglycan degradation during periodontal diseases
VL - 55
ID - 13423
ER -
TY - JOUR
AB - Dental plaque is a biofilm composed of complex microbial communities. It is
the main cause of major dental diseases such as caries and periodontal diseases. In
a healthy state, there is a delicate balance between the dental biofilm and host
tissues. Nevertheless, due to the oral cavity changes, this biofilm can become
pathogenic. The pathogenic biofilm shifts the balance from demineralization-
remineralization to demineralization and results in dental caries. Dentists should
consider caries as a result of biological processes of dental plaque and seek
treatments for the etiologic factors, not merely look for the treatment of the
outcome caused by biofilm, i.e., dental caries. Caries prevention strategies can be
classified into three groups based on the role and responsibility of the
individuals doing them: (1) community-based strategy, (2) dental professionals-
based strategy, and (3) individual-based strategy. The community-based methods
include fluoridation of water, salt, and milk. The dental professionals-based
methods include professional tooth cleaning and use of varnish, fluoride gel and
foam, fissure sealant, and antimicrobial agents. The individual-based (self-care)
methods include the use of fluoride toothpaste, fluoride supplements, fluoride
mouthwashes, fluoride gels, chlorhexidine gels and mouthwashes, slow-release
fluoride devices, oral hygiene, diet control, and noncariogenic sweeteners such as
xylitol. This study aimed to study the research in the recent five years (2015-
2020) to identify the characteristics of dental biofilm and its role in dental
caries and explore the employed approaches to prevent the related infections.
AN - rayyan-563560051
AU - Motallaei, M. N.
AU - Yazdanian, M.
AU - Tebyanian, H.
AU - Tahmasebi, E.
AU - Alam, M.
AU - Abbasi, K.
AU - Seifalian, A.
AU - Ranjbar, R.
AU - Yazdanian, A.
DO - 10.1155/2021/3423001
fluoride
gel
herbaceous agent
mouthwash
prebiotic agent
probiotic agent
silver diamine fluoride
sodium chloride
toothpaste
unclassified drug
water
biofilm
caries prevention
dental caries
dental prophylaxis
dentist
disease control
fluoridation
human
milk
mouth disease
mouth hygiene
nonhuman
polymerization
review
saliva
self care
tooth
tooth infection
tooth plaque
varnish
LA - English
PY - 2021
SN - ["1741-4288", "1741-427X"]
ST - The Current Strategies in Controlling Oral Diseases by Herbal and Chemical
Materials
T2 - Evid.-Based Complement. Altern. Med.
TI - The Current Strategies in Controlling Oral Diseases by Herbal and Chemical
Materials
VL - 2021
ID - 13425
ER -
TY - JOUR
AB - A number of species within the Fusobacteriaceae family of Gram-negative
bacteria uniquely encode for an ornithine decarboxylase/arginase (ODA) that
ostensibly channels l-ornithine generated by hydrolysis of l-arginine to putrescine
formation. However, two aspartate residues required for coordination to a
catalytically obligatory manganese cluster of arginases are substituted for a
serine and an asparagine. Curiously, these natural substitutions occur only in a
clade of Fusobacterium species that inhabit the oral cavity. Herein, we expressed
and isolated full-length ODA from the opportunistic oral pathogen Fusobacterium
nucleatum along with the individual arginase and ornithine decarboxylase
components. The crystal structure of the arginase domain reveals that it adopts the
classical α/β arginase-fold, but metal ions are absent in the active site. As
expected, the ureohydrolase activity with l-arginine was not detected for wild-type
ODA or the isolated arginase domain. However, engineering of the complete metal
coordination environment through site-directed mutagenesis restored Mn2+binding
capacity and arginase activity, although the catalytic efficiency for l-arginine
was low (60-100 M-1s-1). Full-length ODA and the isolated ODC component were able
to decarboxylate both l-ornithine and l-arginine to form putrescine and agmatine,
respectively, but kcat/KMof l-ornithine was ∼20-fold higher compared to l-arginine.
We discuss environmental conditions that may have led to the natural selection of
an inactive arginase in the oral associated species of Fusobacterium.
AN - rayyan-563559822
AU - Mothersole, R. G.
AU - Kolesnikov, M.
AU - Chan, A. C. K.
AU - Oduro, E.
AU - Murphy, M. E. P.
AU - Wolthers, K. R.
DO - 10.1021/acs.biochem.2c00197
IS - 13
KW - high performance liquid chromatograph
mass spectrometer
agmatine
ampicillin
arginase
chloramphenicol
metal ion
ornithine decarboxylase
article
catalytic efficiency
controlled study
crystallization
decarboxylation
Escherichia coli
Fusobacterium
gene amplification
hydrogen bond
inductively coupled plasma atomic emission spectrometry
mouth cavity
nonhuman
periodontal disease
protein expression
protein structure
site directed mutagenesis
spectrophotometry
ultraviolet visible spectrophotometry
LA - English
PY - 2022
SN - ["1520-4995", "0006-2960"]
SP - 1378-1391
ST - Sequence Divergence in the Arginase Domain of Ornithine
Decarboxylase/Arginase in Fusobacteriacea Leads to Loss of Function in Oral
Associated Species
T2 - Biochemistry
TI - Sequence Divergence in the Arginase Domain of Ornithine
Decarboxylase/Arginase in Fusobacteriacea Leads to Loss of Function in Oral
Associated Species
VL - 61
ID - 13196
ER -
TY - JOUR
AB - Periodontal disease is a complex problem which often interrelates with
several serious systemic diseases. However, the satisfactory clinical therapy has
yet to be achieved. Herein, serum albumin microspheres containing minocycline and
zinc oxide nanoparticals (ZnO NPs) were prepared and incorporated in a Carbopol
940((R)) hydrogel. Compared with 2% minocycline ointment (Perio((R))), the hydrogel
has shown obvious therapy effects and the ability of gingival tissue self-
repairing. The serum albumin microspheres containing 0.06% of minocycline and
0.025% of ZnO NPs presented an average size of 139 +/- 0.42 nm using
electrophoretic light scattering (n = 3). Photomicrographs obtained by TEM showed
homogeneous and spherical-shaped particles. The encapsulation efficiency was 99.99%
for minocycline and the slow-release time was more than 72 h with pH-sensitive
property. The in vitro skin adhesion experiment showed that the largest bioadhesive
force is 0.35 N. Moreover, the hydrogel showed broad-spectrum antimicrobial and
effective antibacterial ability when concentration of the ZnO NPs was over 0.2 mu
g/mL. The cell survival rates were more than 85% below 0.8 mg/L of ZnO NPs, which
proved its low toxicity and high security.
AN - rayyan-563562159
AU - Mou, J.
AU - Liu, Z. X.
AU - Liu, J.
AU - Lu, J. W.
AU - Zhu, W. T.
AU - Pei, D. S.
DO - 10.1080/10717544.2019.1571121
IS - 1
PY - 2019
SN - ["1071-7544", "1521-0464"]
SP - 179-187
ST - Hydrogel containing minocycline and zinc oxide-loaded serum albumin
nanopartical for periodontitis application: preparation, characterization and
evaluation
T2 - DRUG DELIVERY
TI - Hydrogel containing minocycline and zinc oxide-loaded serum albumin
evaluation
VL - 26
Y2 - 1 y3 - 1
ID - 15533
ER -
TY - JOUR
AB - Periodontal disease is a complex problem which often interrelates with
several serious systemic diseases. However, the satisfactory clinical therapy has
yet to be achieved. Herein, serum albumin microspheres containing minocycline and
zinc oxide nanoparticals (ZnO NPs) were prepared and incorporated in a Carbopol
940® hydrogel. Compared with 2% minocycline ointment (Perio®), the hydrogel has
shown obvious therapy effects and the ability of gingival tissue self-repairing.
The serum albumin microspheres containing 0.06% of minocycline and 0.025% of ZnO
NPs presented an average size of 139 ± 0.42 nm using electrophoretic light
scattering (n = 3). Photomicrographs obtained by TEM showed homogeneous and
spherical-shaped particles. The encapsulation efficiency was 99.99% for minocycline
and the slow-release time was more than 72 h with pH-sensitive property. The in
vitro skin adhesion experiment showed that the largest bioadhesive force is 0.35 N.
Moreover, the hydrogel showed broad-spectrum antimicrobial and effective
antibacterial ability when concentration of the ZnO NPs was over 0.2 µg/mL. The
cell survival rates were more than 85% below 0.8 mg/L of ZnO NPs, which proved its
low toxicity and high security.
AN - rayyan-563560222
AU - Mou, J.
AU - Liu, Z.
AU - Liu, J.
AU - Lu, J.
AU - Zhu, W.
AU - Pei, D.
DO - 10.1080/10717544.2019.1571121
IS - 1
KW - carbopol 940
microsphere
minocycline
serum albumin
animal experiment
animal model
animal tissue
article
controlled study
electrophoresis
force
gingival tissue
hydrogel
in vitro study
light scattering
male
microphotography
nanoencapsulation
nanopharmaceutics
nonhuman
particle size
periodontitis
pH
priority journal
rat
slow drug release
tissue repair
LA - English
PY - 2019
SN - ["1521-0464", "1071-7544"]
SP - 179-187
ST - Hydrogel containing minocycline and zinc oxide-loaded serum albumin
evaluation
T2 - Drug Deliv.
TI - Hydrogel containing minocycline and zinc oxide-loaded serum albumin
evaluation
VL - 26
ID - 13596
ER -
TY - JOUR
AN - rayyan-563561647
AU - Mubarak, Z.
AU - Sari, W. E.
AU - Sunnati, S.
DO - 10.4103/JIOH.JIOH_23_21
IS - 5
PY - 2021
SP - 508-513
ST - Gel formulation and evaluation of antimicrobial activity of turmeric (Curcuma
longa L.) from Aceh, Indonesia against Aggregatibacter actinomycetemcomitans
T2 - Journal of International Oral Health
TI - Gel formulation and evaluation of antimicrobial activity of turmeric (Curcuma
85117946685&doi=10.4103%2fJIOH.JIOH_23_21&partnerID=40&md5=ddb54937c83eb851da6b7524
1331ed92
VL - 13
ID - 15021
ER -
TY - JOUR
AB - Aim: Periodontitis is a chronic disease of dental tissue caused by a
bacterial infection, for instance, Aggregatibacter actinomycetemcomitans is caused
by dominant bacteria. Currently, there are many cases regarding bacterial
resistance to some antibiotics, so an alternative search for new antibiotics from
herbal plants is needed. Turmeric (Curcuma longa Linn.) is a plant that is known to
contain bioactive compounds that can function as antimicrobials. So far, research
on turmeric extract in the form of a gel formula used as a herbal medicine for
periodontitis in Indonesia has not been reported. The aim of this research was to
study the oral gel formula of the indigenous turmeric extract from Aceh, Indonesia
and to evaluate its antimicrobial efficacy against A. actinomycetemcomitans.
Materials and Methods: This research was designed to test the effectiveness of C.
longa gel in vitro in inhibiting the growth of A. actinomycetemcomitan. Turmeric
rhizome was extracted using the maceration method with 96% ethanol; then, the
extract was formulated into a gel with concentrations of 0%, 25%, 50%, 75%, and
100%. The curcuma gel was then tested for antimicrobials against A.
actinomycetemcomitans bacteria. Results: The in vitro antimicrobial test showed
that a 50% concentration of turmeric rhizome extracts gel was effective in
inhibiting the growth of A. actinomycetemcomitans with an inhibition zone of 10.8
mm, which is classified as a strong inhibition zone. Conclusion: The efficacy of
the oral gel formula containing C. longa extracts as a natural antimicrobial agent
has been confirmed, and the possibility of applying it as periodontitis herbal
medicine has been suggested.
AN - rayyan-563562292
AU - Mubarak, Z.
AU - Sari, W.
AU - Sunnati, S.
DO - 10.4103/JIOH.JIOH_23_21
IS - 5
PY - 2021
SN - ["0976-7428", "0976-1799"]
SP - 508-513
ST - Gel formulation and evaluation of antimicrobial activity of turmeric (Curcuma
T2 - JOURNAL OF INTERNATIONAL ORAL HEALTH
TI - Gel formulation and evaluation of antimicrobial activity of turmeric (Curcuma
VL - 13
Y2 - 9
ID - 15666
ER -
TY - JOUR
AB - Non-surgical periodontal therapy is an integral part of periodontal treatment
and has been defined as plaque removal, plaque control, supra- and subgingival
scaling, root surface debridement, and the adjunctive use of chemical agents.
CLINICAL RELEVANCE: Knowledge of the role of non-surgical periodontal therapy is
central to good patient care.
AN - rayyan-563560743
AU - Mullally, B.
AU - Irwin, C.
AU - Ziada, H.
AU - Allen, E.
AU - Byrne, P. J.
DO - 10.12968/denu.2007.34.6.326
IS - 6
gel
general practice
human
devices
methodology
microbiology
periodontal disease
periodontics
periodontitis
review
tooth calculus
tooth plaque
ultrasound therapy
LA - English
PY - 2007
SN - 0305-5000
SP - 326-328, 330-332, 335-336
ST - Periodontics: 3. Non-surgical periodontal therapy in general dental practice
T2 - Dent Update
TI - Periodontics: 3. Non-surgical periodontal therapy in general dental practice
VL - 34
ID - 14117
ER -
TY - JOUR
AB - Periodontitis is a chronic biofilm-associated inflammatory disease of the
tooth-supporting tissues that causes tooth loss. It is strongly associated with
anaerobic bacterial colonization and represents a substantial global health burden.
Due to a local hypoxic environment, tissue regeneration is impaired. Oxygen therapy
has shown promising results as a potential treatment of periodontitis, but so far,
local oxygen delivery remains a key technical challenge. An oxygen (O-2)-releasing
hyaluronic acid (HA)-based dispersion with a controlled oxygen delivery was
developed. Cell viability of primary human fibroblasts, osteoblasts, and HUVECs was
demonstrated, and biocompatibility was tested using a chorioallantoic membrane
assay (CAM assay). Suppression of anaerobic growth of Porphyromonas gingivalis was
shown using the broth microdilution assay. In vitro assays showed that the O-2-
releasing HA was not cytotoxic towards human primary fibroblasts, osteoblasts, and
HUVECs. In vivo, angiogenesis was enhanced in a CAM assay, although not to a
statistically significant degree. Growth of P. gingivalis was inhibited by CaO2
concentrations higher than 256 mg/L. Taken together, the results of this study
demonstrate the biocompatibility and selective antimicrobial activity against P.
gingivalis for the developed O-2-releasing HA-based dispersion and the potential of
O-2-releasing biomaterials for periodontal tissue regeneration.
AN - rayyan-563562375
AU - Muller-Heupt, L. K.
AU - Wiesmann-Imilowski, N.
AU - Schroder, S.
AU - Gross, J.
AU - Ziskoven, P. C.
AU - Bani, P.
AU - Kammerer, P. W.
AU - Schiegnitz, E.
AU - Eckelt, A.
AU - Eckelt, J.
AU - Ritz, U.
AU - Opatz, T.
AU - Al-Nawas, B.
AU - Synatschke, C. V.
AU - Deschner, J.
DO - 10.3390/ijms24065936
IS - 6
PY - 2023
SN - 1422-0067
ST - Oxygen-Releasing Hyaluronic Acid-Based Dispersion with Controlled Oxygen
Delivery for Enhanced Periodontal Tissue Engineering
TI - Oxygen-Releasing Hyaluronic Acid-Based Dispersion with Controlled Oxygen
Delivery for Enhanced Periodontal Tissue Engineering
VL - 24
Y2 - 3
ID - 15749
ER -
TY - JOUR
AB - The aim of this study was to evaluate the adjunctive benefit offers by the
administration of a chlorhexidine based local drug deliver (Chlo-SITE) into
periodontal socket after a full mouth disinfection session. The study design was a
randomized, crossover, clinical trial conducted on 60 non-smokers subjects with
chronic periodontitis. Each volunteer was subjected to a one-stage full mouth
disinfection session and, immediately after that, test product (Chlo-SITE) was
inserted in 1 pocket in 2 quadrant. The 1° and 4° quadrant were used for the study
with the application of antiseptic (Test); the 2° and 3° as a control. Periodontal
probe (PD), bleeding on probing (BOP) and plaque index (PI) was collected at
baseline (T0), after 7 days (T1), after 4 weeks (T2). The results of this study
suggest that the application of xanthan-based chlorhexidine gel (Xan-CHX) offers a
great benefit in improving of the indices in chronic periodontitis.
AN - rayyan-563560191
AU - Mummolo, S.
AU - Severino, M.
AU - Campanella, V.
AU - Barlattani, A.
AU - Quinzi, V.
AU - Marchetti, E.
IS - 3
KW - syringe
chlo site
unclassified drug
xanthan
xanthan based chlorhexidine
adult
article
clinical article
controlled study
crossover procedure
disinfection
female
gel
human
male
middle aged
mouth hygiene
non-smoker
periodontal pocket
plaque index
root planing
LA - English
PY - 2019
SN - ["1724-6083", "0393-974X"]
SP - 83-88
ST - Chlorhexidine gel used as antiseptic in periodontal pockets
TI - Chlorhexidine gel used as antiseptic in periodontal pockets
VL - 33
ID - 13565
ER -
TY - JOUR
AB - In the last years, several studies testing commercial periodontal gels that
contain chlorhexi-dine (CHX) or other antibacterial agents, have raised concerns
regarding their cytotoxicity in periodontal tissues. We aimed at comparing the
biocompatibility but also the efficacy as regards to the antibacterial and wound
healing ability of different commercial periodontal gels. In vitro human gin-gival
fibroblasts (GF) and a 3D model of human tissue equivalents of gingiva (GTE) were
used under inflammatory conditions to evaluate wound closure, cytotoxicity and gene
expression. Antibacterial effects were also investigated on Porphyromonas
gingivalis growth, viability and gingipain activity. In GF and in the bacterial
study, we found cytotoxic effects on GF and a high inhibition on bacterial growth
rate in gels containing CHX, asiaticoside, enoxolone, cetylpyridinium chloride,
propolis and eugenol. Of the two gels that were non-cytotoxic, Syntoss Biogel
(containing chondrontin sulfate) and Emdogain (EMD, containing amelogenin and
propylene glycol alginate), EMD showed the best wound closure, with no effect on P.
gingivalis growth but decreased gingipain activity. On the other hand, Syntoss
Biogel reduced viability and gingipain activity of P. gingivalis, but lack wound
healing capacity. In the 3D GTE, Syntoss Biogel and EMD showed a good
biocompatibility. Among all the tested gels, formulations containing CHX,
asiaticoside, enoxolone, cetylpyridinium chloride, propolis and eugenol showed high
antibacterial effect but also showed high cytotoxicity in eukaryotic cells. EMD was
the one with the best biocompatibility and wound healing ability at the conditions
tested.
AN - rayyan-563559967
AU - Munar-Bestard, M.
AU - Llopis-Grimalt, M. A.
AU - Ramis, J. M.
AU - Monjo, M.
IS - 9
KW - alginic acid propylene glycol ester
amelogenin
asiaticoside
chondroitin sulfate
dental material
disinfectant agent
eugenol
gel
gingipain cysteine endopeptidase
glycyrrhetinic acid
periodontal gel
propolis
unclassified drug
article
bacterial growth
bacterial viability
biocompatibility
cytotoxicity
drug efficacy
enzyme activity
fibroblast
gene expression
gingiva
human
human cell
in vitro study
nonhuman
wound closure
wound healing
LA - English
PY - 2021
SN - 1999-4923
ST - Comparative in vitro evaluation of commercial periodontal gels on
antibacterial, biocompatibility and wound healing ability
T2 - Pharmaceutics
TI - Comparative in vitro evaluation of commercial periodontal gels on
antibacterial, biocompatibility and wound healing ability
VL - 13
ID - 13341
ER -
TY - JOUR
AN - rayyan-563561871
AU - Münchow, E. A.
AU - Zero, B.
AU - Kamocki, K.
AU - Piva, E.
AU - Gregory, R. L.
AU - Bottino, M. C.
DO - 10.1016/j.dental.2015.06.004
IS - 9
PY - 2015
SP - 1038-1051
ST - Development and characterization of novel ZnO-loaded electrospun membranes
for periodontal regeneration
TI - Development and characterization of novel ZnO-loaded electrospun membranes
84938287205&doi=10.1016%2fj.dental.2015.06.004&partnerID=40&md5=38a14bb588b9c66de0b
ad377ecc6f7a9
VL - 31
ID - 15245
ER -
TY - JOUR
AB - Objectives. This study reports on the synthesis, materials characterization,
antimicrobial capacity, and cytocompatibility of novel ZnO-loaded membranes for
guided tissue/bone regeneration (GTR/GBR). Methods. Poly(epsilon-caprolactone)
(PCL) and PCL/gelatin (PCL/GEL) were dissolved in hexafluoropropanol and loaded
with ZnO at distinct concentrations: 0 (control), 5, 15, and 30 wt.%.
Electrospinning was performed using optimized parameters and the fibers were
characterized via scanning and transmission electron microscopies (SEM/TEM), energy
dispersive X-ray spectroscopy (EDS), Fourier transform infrared spectroscopy
(FTIR), contact angle (CA), mechanical testing, antimicrobial activity against
periodontopathogens, and cytotoxicity test using human dental pulp stem cells
(hDPSCs). Data were analyzed using ANOVA and Tukey (alpha = 5%). Results. ZnO
nanoparticles were successfully incorporated into the overall submicron fibers,
which showed fairly good morphology and microstructure. Upon ZnO nanoparticies'
incorporation, the PCL and PCL/GEL fibers became thicker and thinner, respectively.
All GEL-containing membranes showed lower CA than the PCL-based membranes, which
were highly hydrophobic. Overall, the mechanical properties of the membranes were
reduced upon ZnO incorporation, except for PCL-based membranes containing ZnO at
the 30 wt.% concentration. The presence of GEL enhanced the stretching ability of
membranes under wet conditions. All ZnO-containing membranes displayed
antibacterial activity against the bacteria tested, which was generally more
pronounced with increased ZnO content. All membranes synthesized in this study
demonstrated satisfactory cytocompatibility, although the presence of 30 wt.% ZnO
led to decreased viability. Significance. Collectively, this study suggests that
PCL- and PCL/GEL-based membranes containing a low content of ZnO nanoparticles can
potentially function as a biologically safe antimicrobial GTR/GBR membrane. (C)
2015 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.
AN - rayyan-563562298
AU - Munchow, E. A.
AU - Zero, B.
AU - Kamocki, K.
AU - Piva, E.
AU - Gregory, R. L.
AU - Bottino, M. C.
DO - 10.1016/j.dental.2015.06.004
IS - 9
PY - 2015
SN - ["0109-5641", "1879-0097"]
SP - 1038-1051
T2 - DENTAL MATERIALS
VL - 31
Y2 - 9
ID - 15672
ER -
TY - JOUR
AB - OBJECTIVES: This study reports on the synthesis, materials characterization,
antimicrobial capacity, and cytocompatibility of novel ZnO-loaded membranes for
guided tissue/bone regeneration (GTR/GBR). METHODS: Poly(ɛ-caprolactone) (PCL) and
PCL/gelatin (PCL/GEL) were dissolved in hexafluoropropanol and loaded with ZnO at
distinct concentrations: 0 (control), 5, 15, and 30wt.%. Electrospinning was
performed using optimized parameters and the fibers were characterized via scanning
and transmission electron microscopies (SEM/TEM), energy dispersive X-ray
spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), contact angle
(CA), mechanical testing, antimicrobial activity against periodontopathogens, and
cytotoxicity test using human dental pulp stem cells (hDPSCs). Data were analyzed
using ANOVA and Tukey (α=5%). RESULTS: ZnO nanoparticles were successfully
incorporated into the overall submicron fibers, which showed fairly good morphology
and microstructure. Upon ZnO nanoparticles' incorporation, the PCL and PCL/GEL
fibers became thicker and thinner, respectively. All GEL-containing membranes
showed lower CA than the PCL-based membranes, which were highly hydrophobic.
Overall, the mechanical properties of the membranes were reduced upon ZnO
incorporation, except for PCL-based membranes containing ZnO at the 30wt.%
concentration. The presence of GEL enhanced the stretching ability of membranes
under wet conditions. All ZnO-containing membranes displayed antibacterial activity
against the bacteria tested, which was generally more pronounced with increased ZnO
content. All membranes synthesized in this study demonstrated satisfactory
cytocompatibility, although the presence of 30wt.% ZnO led to decreased viability.
SIGNIFICANCE: Collectively, this study suggests that PCL- and PCL/GEL-based
membranes containing a low content of ZnO nanoparticles can potentially function as
a biologically safe antimicrobial GTR/GBR membrane.
AN - rayyan-563560376
AU - Münchow, E. A.
AU - Albuquerque, M. T.
AU - Zero, B.
AU - Kamocki, K.
AU - Piva, E.
AU - Gregory, R. L.
AU - Bottino, M. C.
DO - 10.1016/j.dental.2015.06.004
IS - 9
artificial membrane
gelatin
lipid bilayer
metal nanoparticle
polycaprolactone
polyester
zinc oxide
adult stem cell
alveolar bone loss
bone regeneration
cell culture
chemistry
human
physiology
tissue regeneration
tooth pulp
LA - English
PY - 2015
SN - 1879-0097
SP - 1038-1051
T2 - Dent Mater
VL - 31
ID - 13750
ER -
TY - JOUR
AB - This study reports on the development of novel biodegradable microspheres
prepared by water-in-oil-water (W/O/W) double emulsion technique using the blends
of poly(d,l-lactide-co-glycolide) (PLGA) and poly(ε-caprolactone) (PCL) in
different ratios for the controlled delivery of doxycycline (DXY). Doxycycline
encapsulation of up to 24% was achieved within the polymeric microspheres. Blend
placebo microspheres, drug-loaded microspheres and pristine DXY were analyzed by
Fourier transform infrared spectroscopy (FT-IR), which indicated no interaction
between drug and polymers. Differential scanning calorimetry (DSC) on drug-loaded
microspheres confirmed the polymorphism of DXY and indicated a molecular level
dispersion of DXY in the microspheres. Scanning electron microscopy (SEM) confirmed
the spherical nature and smooth surfaces of the microspheres produced. Mean
particle size of the microspheres as measured by dynamic laser light scattering
method ranged between 90 and 200 μm. In vitro release studies performed in 7.4 pH
media indicated the release of DXY from 7 to 11 days, depending upon the blend
ratio of the matrix. Up to 11 days, DXY concentrations in the gingival crevicular
fluid were higher than the minimum inhibitory concentration of DXY against most of
the periodontal pathogens. One of the developed formulations was subjected to in
vivo efficacy studies in thirty sites of human periodontal pockets. Significant
results were obtained with respect to both microbiological and clinical parameters
up to 3 months even as compared to commercial DXY gel. Statistical analyses of the
release data and in vivo results were performed using the analysis of variance
(ANOVA) method. © 2007 Elsevier B.V. All rights reserved.
AN - rayyan-563560745
AU - Mundargi, R. C.
AU - Srirangarajan, S.
AU - Agnihotri, S. A.
AU - Patil, S. A.
AU - Ravindra, S.
AU - Setty, S. B.
AU - Aminabhavi, T. M.
DO - 10.1016/j.jconrel.2007.01.008
IS - 1
KW - doxycycline
microsphere
polycaprolactone
polyglactin
polymer
article
biodegradability
controlled study
drug formulation
emulsion
encapsulation
evaluation study
gel
gingiva
human
in vitro study
in vivo study
normal human
particle size
periodontitis
pH
priority journal
surface property
LA - English
PY - 2007
SN - 0168-3659
SP - 59-68
ST - Development and evaluation of novel biodegradable microspheres based on
poly(d,l-lactide-co-glycolide) and poly(ε-caprolactone) for controlled delivery of
doxycycline in the treatment of human periodontal pocket: In vitro and in vivo
studies
TI - Development and evaluation of novel biodegradable microspheres based on
poly(d,l-lactide-co-glycolide) and poly(ε-caprolactone) for controlled delivery of
doxycycline in the treatment of human periodontal pocket: In vitro and in vivo
studies
VL - 119
ID - 14119
ER -
TY - JOUR
AB - Oral cavity can be used for local drug delivery as in for periodontitis,
dental caries or for oral mucosal drug delivery as for alveolar osteitis, analgesia
or transmucosal systemic effect as for smoking cessation or delivery of
biotechnological products like proteins and peptides. This article gives an
overview of basic structure, function, biochemistry, and permeability of the oral
cavity. Different diseases affecting orodental region along with conventional as
well as new and emerging drug delivery and technologies that address the unmet
patient and market needs for improved local drug therapy to this region are
discussed in this article. Regulatory and Clinical aspects of this type of drug
delivery are very important and are taken into consideration in this article. The
aim of this review is to provide the reader a general and inspiring prospect on
recent and promising fields of innovation in oral drug delivery.
AN - rayyan-563560476
AU - Munot, N. M.
AU - Gujar, K. N.
IS - 3
KW - acrylic acid
carbomer
cellulose acetate
chitosan
chlorhexidine
cholesterol ester
dipalmitoylphosphatidylcholine
gelatin
glucosylceramide
glycosphingolipid
hydroxyapatite
immunoglobulin A
lactoferrin
levofloxacin
liposome
lysozyme
metronidazole
microsphere
mucin
nanoparticle
oligonucleotide
polycaprolactone
polypropylene
polysaccharide
polyurethan
sphingomyelin
stearic acid
unindexed drug
anatomy
aphthous stomatitis
bacteremia
cell membrane permeability
dental caries
dental pellicle
drug absorption
drug dosage form
enamel
fiber
gingiva bleeding
gingivitis
halitosis
human
hydrogel
mouth cavity
mouth mucosa
mucoadhesion
mucosal drug administration
oral bleeding
osteitis
periodontal pocket
periodontitis
physiology
review
saliva
tablet
test strip
tooth pain
xerostomia
LA - English
PY - 2013
SN - 0975-1491
SP - 74-83
ST - Orodental delivery systems: An overview
TI - Orodental delivery systems: An overview
VL - 5
ID - 13850
ER -
TY - JOUR
AB - Background and Objective: Determination of the interleukin-1 (IL-1) signaling
cascades that lead to the production of various inflammatory mediators and
catabolic factors may clarify attractive targets for therapeutic intervention for
periodontitis. We comprehensively assessed the involvement of MAPKs, activator
protein-1 (AP-1) and nuclear factor-κB (NF-κB) in IL-1β-induced production of
interleukin-6 (IL-6), interleukin-8 (IL-8), prostaglandinE2 (PGE2) and MMP-1 in
human periodontal ligament cells. Material and Methods: Human periodontal ligament
cells were pretreated with an inhibitor for each of the MAPKs or NF-κB and
subsequently treated with IL-1β. Following treatment, phosphorylation of three
types of MAPK (ERK, p38 MAPK and c-Jun N-terminal kinase), IκB kinase (IKK) α/β/γ
and IκB-α, as well as the DNA binding activity of AP-1 and NF-κB and the production
of IL-6, IL-8, PGE2 and MMP-1, were determined by western blotting, a gel mobility
shift assay and ELISA, respectively. Results: The three MAPKs, simultaneously
activated by IL-1β, mediated the subsequent DNA binding of AP-1 at various
magnitudes, while IKKα/β/γ, IκB-α and NF-κB were also involved in the IL-1
signaling cascade. Furthermore, IL-1β stimulated the production of IL-6, IL-8, PGE2
and MMP-1 via activation of the three MAPKs and NF-κB, because inhibitors of these
significantly suppressed the IL-1β-stimulated production of these factors.
Conclusion: Our results strongly suggest that MAPK, AP-1 and NF-κB mediate the IL-
1β-stimulated synthesis of IL-6, IL-8, PGE2 and MMP-1 in human periodontal ligament
cells. Therefore, inhibition of activation of MAPK, AP-1 and/or NF-κB may lead to
therapeutic effects on progression of periodontitis. © 2011 John Wiley & Sons A/S.
AN - rayyan-563560575
AU - Murayama, R.
AU - Kobayashi, M.
AU - Takeshita, A.
AU - Yasui, T.
AU - Yamamoto, M.
DO - 10.1111/j.1600-0765.2011.01374.x
IS - 5
KW - cytokine
interleukin 1beta
interleukin 6
interleukin 8
prostaglandin E2
adolescent
adult
article
biosynthesis
cell culture
cytology
drug antagonism
human
metabolism
physiology
signal transduction
LA - English
PY - 2011
SN - ["0022-3484", "1600-0765"]
SP - 568-575
ST - MAPKs, activator protein-1 and nuclear factor-κB mediate production of
interleukin-1β-stimulated cytokines, prostaglandinE2 and MMP-1 in human periodontal
ligament cells
TI - MAPKs, activator protein-1 and nuclear factor-κB mediate production of
interleukin-1β-stimulated cytokines, prostaglandinE2 and MMP-1 in human periodontal
ligament cells
VL - 46
ID - 13949
ER -
TY - JOUR
AN - rayyan-563561460
AU - Muresan, S. M. C.
AU - Dreanca, A.
AU - Repciuc, C.
AU - Dejescu, C.
AU - Rotar, O.
AU - Pop, R. A.
AU - Pantea, S.
AU - Pall, E.
AU - Ciotlaus, I.
AU - Sarosi, C.
AU - Mohan, A. G.
AU - Moldovan, M.
AU - Oana, L.
DO - 10.3390/app13031787
IS - 3
PY - 2023
ST - Dental Hydrogels with Essential Oils with Potential Activity in Periodontitis
T2 - Applied Sciences (Switzerland)
TI - Dental Hydrogels with Essential Oils with Potential Activity in Periodontitis
85147993720&doi=10.3390%2fapp13031787&partnerID=40&md5=d9e8ec2b98f67b75172e719fe02d
f1ca
VL - 13
ID - 14834
ER -
TY - JOUR
AB - Periodontitis treatment is usually focused on the reduction or eradication of
periodontal pathogens using antibiotics against anaerobic bacteria, such as
metronidazole (MTR). Moreover, recently the correlation between periodontal
diseases and overexpression of reactive oxygen species (ROS) led to the
introduction of antioxidant biomolecules in therapy. In this work, bioadhesive
buccal tablets, consisting of a hydrophilic matrix loaded with metronidazole and
lipophilic nanoparticles as a vehicle of curcumin, were developed. Curcumin (CUR)-
loaded nanostructured lipid carriers (NLC) were prepared using glycyrrhetic acid,
hexadecanol, isopropyl palmitate and Tween(®)80 as a surfactant. As method,
homogenization followed by high-frequency sonication was used. After dialysis, CUR-
NLC dispersion was evaluated in terms of drug loading (DL, 2.2% w/w) and drug
recovery (DR, 88% w/w). NLC, characterized by dynamic light scattering and scanning
electron microscopy (SEM), exhibited a spherical shape, an average particle size of
121.6 nm and PDI and PZ values considered optimal for a colloidal nanoparticle
dispersion indicating good stability of the system. Subsequently, a hydrophilic
sponge was obtained by lyophilization of a gel based on trehalose, Natrosol and
PVP-K90, loaded with CUR-NLC and MTR. By compression of the sponge, matrix tablets
were obtained and characterized in term of porosity, swelling index, mucoadhesion
and drugs release. The ability of the matrix tablets to release CUR and MTR when
applied on buccal mucosa and the aptitude of actives to penetrate and/or permeate
the tissue were evaluated. The data demonstrate the ability of NLC to promote the
penetration of CUR into the lipophilic domains of the mucosal membrane, while MTR
can penetrate and permeate the mucosal tissue, where it can perform a loco-regional
antibacterial activity. These results strongly support the possibility of using
this novel matrix tablet for delivering MTR together with CUR for topical treatment
of periodontal diseases.
AN - rayyan-563561305
AU - Murgia, D.
AU - Angellotti, G.
AU - D'Agostino, F.
AU - De Caro, V.
DO - 10.3390/polym11111801
IS - 11
LA - eng
N1 - Dipartimento di Discipline Chirurgiche, Oncologiche e Stomatologiche,
Università degli Studi di Palermo, 90127 Palermo, Italy. denise.murgia@unipa.it.;
Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche
(STEBICEF), Università degli Studi di Palermo, 90123 Palermo, Italy.
denise.murgia@unipa.it.; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e
Farmaceutiche (STEBICEF), Università degli Studi di Palermo, 90123 Palermo, Italy.
angellotti.gius@gmail.com.; Istituto per lo Studio degli Impatti Antropici e
Sostenibilità dell'Ambiente Marino, Consiglio Nazionale delle Ricerche (IAS - CNR),
Campobello di Mazara, 91021 Trapani, Italy. fabio.dagostino@cnr.it.; Dipartimento
di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università
degli Studi di Palermo, 90123 Palermo, Italy. viviana.decaro@unipa.it.
PY - 2019
ST - Bioadhesive Matrix Tablets Loaded with Lipophilic Nanoparticles as Vehicles
for Drugs for Periodontitis Treatment: Development and Characterization
T2 - Polymers
TI - Bioadhesive Matrix Tablets Loaded with Lipophilic Nanoparticles as Vehicles
for Drugs for Periodontitis Treatment: Development and Characterization
VL - 11
Y2 - 11 y3 - 2
ID - 14679
ER -
TY - JOUR
AN - rayyan-563560876
AU - Nafar, M.
AU - Ataie, R.
AU - Einollahi, B.
AU - Nematizadeh, F.
AU - Firoozan, A.
AU - Poorrezagholi, F.
DO - 10.1016/j.transproceed.2003.09.067
IS - 7
KW - amoxicillin
azathioprine
azithromycin
cyclosporine
prednisone
adolescent
adult
clinical article
clinical trial
conference paper
controlled study
dental procedure
drug efficacy
female
follow up
gel
gingiva bleeding
gingiva overgrowth
gingivitis
human
kidney function
kidney graft
kidney transplantation
male
patient selection
priority journal
side effect
skin incision
tooth crown
treatment outcome
LA - English
PY - 2003
SN - 0041-1345
SP - 2727-2728
ST - A comparison between the efficacy of systemic and local azithromycin therapy
in treatment of cyclosporine induced gingival overgrowth in kidney transplant
patients
T2 - Transplant. Proc.
TI - A comparison between the efficacy of systemic and local azithromycin therapy
in treatment of cyclosporine induced gingival overgrowth in kidney transplant
patients
VL - 35
ID - 14250
ER -
TY - JOUR
AB - The hypoxia-inducible factor 1α (HIF-1α) is critically involved in tissue
regeneration. Hence, the pharmacological prevention of HIF-1α degradation by prolyl
hydroxylase (PHD) under normoxic conditions is emerging as a promising option in
regenerative medicine. Using a mouse model of ligature-induced periodontitis and
resolution, we tested the ability of an injectable hydrogel-formulated PHD
inhibitor, 1,4-dihydrophenonthrolin-4-one-3-carboxylic acid (1,4-DPCA/hydrogel), to
promote regeneration of alveolar bone lost owing to experimental periodontitis.
Mice injected subcutaneously with 1,4-DPCA/hydrogel at the onset of periodontitis
resolution displayed significantly increased gingival HIF-1α protein levels and
bone regeneration, as compared to mice treated with vehicle control. The
1,4-DPCA/hydrogel-induced increase in bone regeneration was associated with
elevated expression of osteogenic genes, decreased expression of pro-inflammatory
cytokine genes, and increased abundance of FOXP3+ T regulatory (Treg) cells in the
periodontal tissue. The enhancing effect of 1,4-DPCA/hydrogel on Treg cell
accumulation and bone regeneration was reversed by AMD3100, an antagonist of the
chemokine receptor CXCR4 that mediates Treg cell recruitment. In conclusion, the
administration of 1,4-DPCA/hydrogel at the onset of periodontitis resolution
promotes CXCR4-dependent accumulation of Treg cells and alveolar bone regeneration,
suggesting a novel approach for regaining bone lost due to periodontitis.
AN - rayyan-563560088
AU - Nagai, K.
AU - Ideguchi, H.
AU - Kajikawa, T.
AU - Li, X.
AU - Chavakis, T.
AU - Cheng, J.
AU - Messersmith, P. B.
AU - Heber-Katz, E.
AU - Hajishengallis, G.
DO - 10.1096/fj.202001248R
IS - 10
KW - 1,4 dihydrophenonthrolin 4 one 3 carboxylic acid
carboxylic acid derivative
cytotoxic T lymphocyte antigen 4
hydrogel
interleukin 10
interleukin 17
interleukin 6
osteocalcin
oxygenase inhibitor
plerixafor
procollagen proline 2 oxoglutarate 4 dioxygenase
transcription factor FOXP3
unclassified drug
vasculotropin
alveolar bone
alveolar bone loss
animal experiment
animal model
animal tissue
article
bone development
bone regeneration
CD4+ T lymphocyte
controlled study
female
gingival tissue
human
human cell
male
mouse
nonhuman
periodontium
priority journal
LA - English
PY - 2020
SN - ["1530-6860", "0892-6638"]
SP - 13726-13740
ST - An injectable hydrogel-formulated inhibitor of prolyl-4-hydroxylase promotes
T regulatory cell recruitment and enhances alveolar bone regeneration during
resolution of experimental periodontitis
T2 - FASEB J.
TI - An injectable hydrogel-formulated inhibitor of prolyl-4-hydroxylase promotes
T regulatory cell recruitment and enhances alveolar bone regeneration during
resolution of experimental periodontitis
VL - 34
ID - 13462
ER -
TY - JOUR
AB - Previous reports have shown that azithromycin (AZM), a macrolide antibiotic,
affects collagen synthesis and cytokine production in human gingival fibroblasts
(hGFs). However, there are few reports on the effect of AZM on human periodontal
ligament fibroblasts (hPLFs). In the present study, we comparatively examined the
effects of AZM on hGFs and hPLFs. We monitored the reaction of AZM under
lipopolysaccharide (LPS) stimulation or no stimulation in hGFs and hPLFs. Gene
expression analyses of interleukin-6 (IL-6), interleukin-8 (IL-8), matrix
metalloproteinase-1 (MMP-1), matrix metalloproteinase-2 (MMP-2), and Type 1
collagen were performed using reverse transcription-polymerase chain reaction (RT-
PCR). Subsequently, we performed Western blotting for the analysis of the
intracellular signal transduction pathway. In response to LPS stimulation, the gene
expression levels of IL-6 and IL-8 in hGFs increased due to AZM in a concentration-
dependent manner, and phosphorylation of nuclear factor kappa B (NF-κB) was also
promoted. Additionally, AZM caused an increase in MMP-1 expression in hGFs, whereas
it did not affect the expression of any of the analyzed genes in hPLFs. Our
findings indicate that AZM does not affect hPLFs and acts specifically on hGFs.
Thus, AZM may increase the expression of IL-6 and IL-8 under LPS stimulation to
modify the inflammatory response and increase the expression of MMP-1 to promote
connective tissue remodeling.
AN - rayyan-563560030
AU - Nagano, T.
AU - Yamaguchi, T.
AU - Kajiyama, S.
AU - Suzuki, T.
AU - Matsushima, Y.
AU - Yashima, A.
AU - Shirakawa, S.
AU - Gomi, K.
DO - 10.3390/jcm10010099
IS - 1
KW - densitometer
azithromycin
collagen type 1
gelatinase A
interleukin 6
interleukin 8
Taq polymerase
article
cell proliferation
controlled study
cytokine production
densitometry
gingival tissue
human
human cell
signal transduction
LA - English
PY - 2021
SN - 2077-0383
SP - 1-10
ST - Effect of azithromycin on proinflammatory cytokine production in gingival
fibroblasts and the remodeling of periodontal tissue
T2 - J. Clin. Med.
TI - Effect of azithromycin on proinflammatory cytokine production in gingival
fibroblasts and the remodeling of periodontal tissue
VL - 10
ID - 13404
ER -
TY - JOUR
AB - The goal of periodontal therapy is to prevent, arrest, control or eliminate
periodontitis. It has been reported that scaling and root planning, when combined
with local delivery system such as sub gingival medicament reduces microbes and
improves clinical parameters better than scaling and root planning alone. Therefore
the aim of the present study was to compare the clinical efficacy between two
medicaments, delivered in gel form, one containing metronidazole and the other
containing curcumin, as an adjunct to mechanotherapy. Fifteen subjects were
selected, based on the inclusion and exclusion criteria of both sexes, in a split
mouth design. Selected sites were randomly divided into two groups (group A -
metronidazole whereas group B - curcumin) and the following clinical parameters
such as gingival index (GI), modified sulcular bleeding index (mSBI), probing
pocket depth (PPD) were recorded and assessed on day 0 and 30th days. When compared
with metronidazole, a significant decrease in all clinical parameters was seen
using curcumin. This study revealed that the experimental local drug i.e. curcumin
used along with scaling and root planning is effective in reducing gingival
inflammation and reducing pocket depth.
AN - rayyan-563560454
AU - Nagarathna, D. V.
AU - Scariya, L.
DO - 10.7897/2277-4343.056138
IS - 6
KW - curcumin
metronidazole
article
clinical article
controlled study
diagnostic procedure
drug efficacy
female
gingival index
gingivitis
human
male
modified sulcular bleeding index
periodontics
periodontitis
scale up
LA - English
PY - 2014
SN - ["2229-3566", "2277-4343"]
SP - 680-684
ST - Curcumin and metronidazole in periodontal therapy
T2 - Int. J. Res. Ayurveda Pharm.
TI - Curcumin and metronidazole in periodontal therapy
VL - 5
ID - 13828
ER -
TY - JOUR
AB - BACKGROUND: The formation of new connective periodontal attachment is
contingent upon the elimination or marked reduction of pathogens at the treated
periodontal site. An anti-microbial agent, i.e. moxifloxacin has been incorporated
into the bone graft to control infection and facilitate healing during and after
periodontal therapy. MATERIALS AND METHODS: By purposive sampling, 15 patients with
at least two contralateral vertical defect sites were selected. The selected sites
in each individual were divided randomly into test and control sites according to
split-mouth design. Test site received moxifloxacin-hydroxyapatite composite graft
and control site received hydroxyapatite-placebo gel composite graft. Probing depth
(PD) and Clinical attachment level (CAL) were assessed at baseline, 3, 6, 9, and 12
months. Bone probing depth (BPD) and hard tissue parameters such as amount of
defect fill, percentage of defect fill, and changes in alveolar crest were assessed
at baseline, 6, and 12 months. Changes in subgingival microflora were also assessed
by culturing the subgingival plaque samples at baseline and at 3-month follow-up.
The clinical, radiographic, and microbiological data obtained were subjected to
statistical analysis using descriptive statistics, paired sample t-test,
independent t-test, and contingency test. RESULTS: On intragroup comparison at test
and control sites, there was a significant improvement in all clinical and
radiographic parameters. However, on intergroup comparison of the same, there was
no statistically significant difference between test and control sites at any
interval. Although test sites showed slightly higher amount of bone fill, it was
not statistically significant. There was a significant reduction in the counts of
Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis at both sites
from baseline to 3 months. In addition, there was a significant reduction at test
sites as compared to control sites at 3-month follow-up (P = 0.003 and P = 0.013).
CONCLUSION: The reduction in microbial counts found in test sites at 3-month
follow-up could not bring similar significant improvements in the clinical and
radiographic parameters though the test sites showed slightly higher bone fill.
AN - rayyan-563561386
AU - Nagarjuna Reddy, Y. V.
AU - Deepika, P. C.
AU - Venkatesh, M. P.
AU - Rajeshwari, K. G.
DO - 10.4103/0976-237X.188564
IS - 3
LA - eng
N1 - Department of Periodontology, JSS Dental College and Hospital, JSS
University, Mysuru, Karnataka, India.; Department of Periodontology, JSS Dental
College and Hospital, JSS University, Mysuru, Karnataka, India.; Department of
Pharmaceutics, JSS College of Pharmacy, JSS University, Mysuru, Karnataka, India.;
Department of Microbiology, JSS Medical College, JSS University, Mysuru, Karnataka,
India.
PY - 2016
SN - 0976-237X (Print)
SP - 357-65
ST - Evaluation of moxifloxacin-hydroxyapatite composite graft in the regeneration
of intrabony defects: A clinical, radiographic, and microbiological study
TI - Evaluation of moxifloxacin-hydroxyapatite composite graft in the regeneration
of intrabony defects: A clinical, radiographic, and microbiological study
VL - 7
Y2 - 7
ID - 14760
ER -
TY - JOUR
AB - Background/aims: Macrocarpals, which are phloroglucinol derivatives contained
in eucalyptus leaves, exhibit antimicrobial activity against a variety of bacteria
including oral bacteria. This study examined effects of macrocarpals A, B, and C on
periodontopathic bacteria, especially Porphyromonas gingivalis. Methods:
Macrocarpals A, B, and C were purified from a 60% ethanol-extract of Eucalyptus
globules leaves. To investigate antibacterial activity, representative
periodontopathic bacteria were cultured in media with or without various amounts of
macrocarpals; subsequently, the optical density at 660 nm was measured. Macrocarpal
inhibition of P. gingivalis Arg- and Lys-specific proteinases was assessed by
spectrofluorophotometric assay and sodium dodecyl sulfate-polyacrylamide gel
electrophoresis analysis. The effect of macrocarpals on P. gingivalis binding to
saliva-coated hydroxyapatite beads was examined with 3H-labeled P. gingivalis.
Results: Growth of P. gingivalis was inhibited more strongly than growth of
Prevotella intermedia or Prevotella nigrescens and Treponema denticola by
macrocarpals, however, Actinobacillus actinomycetemcomitans and Fusobacterium
nucleatum were much more resistant. Macrocarpals inhibited P. gingivalis Arg- and
Lys-specific proteinases in a dose-dependent manner. The enzyme-inhibitory effect
of macrocarpals was confirmed by sodium dodecyl sulfate-polyacrylamide gel
electrophoresis analysis in which hemoglobin degradation by P. gingivalis
proteinase was inhibited by macrocarpals. P. gingivalis binding to saliva-coated
hydroxyapatite beads was also strongly attenuated by macrocarpals. Conclusions:
Macrocarpals A, B and C demonstrated antibacterial activity against
periodontopathic bacteria. Among tested bacteria, P. gingivalis displayed the
greatest sensitivity to macrocarpals; additionally, its trypsin-like proteinase
activity and binding to saliva-coated hydroxyapatite beads were inhibited by
macrocarpals. These results indicate that eucalyptus leaf extracts may be useful as
a potent preventative of periodontal disease. © Blackwell Munksgaard, 2006.
AN - rayyan-563560769
AU - Nagata, H.
AU - Inagaki, Y.
AU - Yamamoto, Y.
AU - Maeda, K.
AU - Kataoka, K.
AU - Osawa, K.
AU - Shizukuishi, S.
DO - 10.1111/j.1399-302X.2006.00269.x
IS - 3
KW - alcohol
arginine
Eucalyptus extract
hemoglobin
hydroxyapatite
lysine
macrocarpal a
macrocarpal b
macrocarpal c
phloroglucinol derivative
proteinase
tritium
unclassified drug
article
bacterial growth
bacterium adherence
biological activity
controlled study
culture medium
drug effect
drug purification
drug sensitivity
drug tolerance
enzyme inhibition
enzyme specificity
Eucalyptus
Eucalyptus globulus
fluorophotometry
growth inhibition
inhibition kinetics
isotope labeling
measurement
nonhuman
optical density
pathogenesis
periodontal disease
protein degradation
saliva
species comparison
spectrofluorometry
Treponema denticola
LA - English
PY - 2006
SN - ["0902-0055", "1399-302X"]
SP - 159-163
ST - Inhibitory effects of macrocarpals on the biological activity of
Porphyromonas gingivalis and other periodontopathic bacteria
TI - Inhibitory effects of macrocarpals on the biological activity of
Porphyromonas gingivalis and other periodontopathic bacteria
VL - 21
ID - 14143
ER -
TY - JOUR
AB - Purpose: To evaluate the efficacy of pluronic F-127 gel containing green tea
catechin extract as a local drug delivery system in the treatment of chronic
periodontitis. Methods: A total of 20 chronic periodontitis patients participated
as per the set inclusion and exclusion criteria. Complete scaling and root planing
(SRP) was done for all subjects and pluronic F-127 gel containing green tea
catechin was applied on one site. The contralateral site received SRP alone. The
plaque index (PI), gingival index (GI), and probing pocket depth (PPD) were
recorded at baseline and on the 28th day. Results: At the 28th-day follow-up, green
tea catechin tooth sites showed significantly lower mean scores (GI = 0.55, p =
0.30 and PPD = 3.35 mm) than the corresponding SRP tooth sites (GI = 1.25, PI =
1.15, and PPD = 4.40 mm) (p < 0.05). Conclusion: When compared to scaling and root
planing alone, the local drug delivery gel containing green tea catechin as an
adjuvant was more effective in reducing the clinical parameters of periodontitis.
AN - rayyan-563560149
AU - Nagate, R. R.
AU - Yuvaraja, M.
AU - AlQahtani, S. M.
AU - AlQahtani, N. A.
AU - Tikare, S.
AU - Gokhale, S. T.
AU - Ravi, K. S.
AU - Elagib, M. F. A.
DO - 10.4314/tjpr.v19i2.27
IS - 2
KW - Coe-Pak
gel
pf 127
poloxamer
sinecatechins
adult
article
clinical article
controlled study
dental scaling
drug efficacy
female
follow up
gingival index
human
male
periodontal pocket
plaque index
root planing
tea
LA - English
PY - 2020
SN - ["1596-9827", "1596-5996"]
SP - 427-432
ST - Efficacy of Pluronic F-127 gel containing green tea catechin extract on
chronic periodontitis - A clinical study
TI - Efficacy of Pluronic F-127 gel containing green tea catechin extract on
chronic periodontitis - A clinical study
VL - 19
ID - 13523
ER -
TY - JOUR
AB - Various modalities of treatment are available for different dental diseases,
but the major drawback of these conventional drug therapies is the numerous side
effects associated with their use. This has led to renewed interest in the
discovery of novel anti-infective natural compounds derived from plants. Plants
have been the major source of medicine since the time immemorial. Turmeric has been
attributed a number of medicinal properties in the traditional system of medicine.
The objective of this article is to review the efficacy of turmeric herb in
maintenance of oral health, in particular, and overall health, in general.
Turmeric, a rhizome of Curcuma longa, is a herb known for its medicinal properties
and is a more acceptable and viable option for a common man. It has proven
properties like anti-inflammatory, antioxidant, antimicrobial, hepatoprotective,
immunostimulant, antiseptic, and antimutagenic. Due to these properties, it is
quite useful in dentistry as well. It has a role in the treatment of periodontal
diseases and oral cancers. Turmeric can also be used as a pit and fissure sealant,
mouth wash, and subgingival irrigant in different preparations. It can also be used
as a component in local drug delivery system in gel form.
AN - rayyan-563561316
AU - Nagpal, M.
AU - Sood, S.
DO - 10.4103/0976-9668.107253
IS - 1
J2 - J Nat Sci Biol Med
LA - eng
N1 - Department of Oral Pathology, Dr. H.S. Judge Institute of Dental Sciences and
Hospital, Punjab University, Chandigarh, India.
PY - 2013
SN - 0976-9668 (Print)
SP - 3-7
ST - Role of curcumin in systemic and oral health: An overview
T2 - Journal of natural science, biology, and medicine
TI - Role of curcumin in systemic and oral health: An overview
VL - 4
Y2 - 1
ID - 14690
ER -
TY - JOUR
AB - Background Halitosis or bad breath is a symptom in which a noticeably
unpleasant breath odour is present due to an underlying oral or systemic disease.
50% to 60% of the world population has experienced this problem which can lead to
social stigma and loss of self-confidence. Multiple interventions have been tried
to control halitosis ranging from mouthwashes and toothpastes to lasers. This new
Cochrane Review incorporates Cochrane Reviews previously published on tongue
scraping and mouthrinses for halitosis. Objectives The objectives of this review
were to assess the effects of various interventions used to control halitosis due
to oral diseases only. We excluded studies including patients with halitosis
secondary to systemic disease and halitosis-masking interventions. Search methods
Cochrane Oral Health's Information Specialist searched the following databases:
Cochrane Oral Health's Trials Register (to 8 April 2019), the Cochrane Central
Register of Controlled Trials (CENTRAL; 2019, Issue 3) in the Cochrane Library
(searched 8 April 2019), MEDLINE Ovid (1946 to 8 April 2019), and Embase Ovid (1980
to 8 April 2019). We also searched LILACS BIREME (1982 to 19 April 2019), the
National Database of Indian Medical Journals (1985 to 19 April 2019), OpenGrey
(1992 to 19 April 2019), and CINAHL EBSCO (1937 to 19 April 2019). The US National
Institutes of Health Ongoing Trials Register ClinicalTrials.gov (8 April 2019), the
World Health Organization International Clinical Trials Registry Platform (8 April
2019), the ISRCTN Registry (19 April 2019), the Clinical Trials Registry - India
(19 April 2019), were searched for ongoing trials. We also searched the cross-
references of included studies and systematic reviews published on the topic. No
restrictions were placed on the language or date of publication when searching the
electronic databases. Selection criteria We included randomised controlled trials
(RCTs) which involved adults over the age of 16, and any intervention for managing
halitosis compared to another or placebo, or no intervention. The active
interventions or controls were administered over a minimum of one week and with no
upper time limit. We excluded quasi-randomised trials, trials comparing the results
for less than one week follow-up, and studies including advanced periodontitis.
Data collection and analysis Two pairs of review authors independently selected
trials, extracted data, and assessed risk of bias. We estimated mean differences
(MDs) for continuous data, with 95% confidence intervals (CIs). We assessed the
certainty of the evidence using the GRADE approach. Main results We included 44
trials in the review with 1809 participants comparing an intervention with a
placebo or a control. The age of participants ranged from 17 to 77 years. Most of
the trials reported on short-term follow-up (ranging from one week to four weeks).
Only one trial reported long-term follow-up (three months). Three studies were at
low overall risk of bias, 16 at high overall risk of bias, and the remaining 25 at
unclear overall risk of bias. We compared different types of interventions which
were categorised as mechanical debridement, chewing gums, systemic deodorising
agents, topical agents, toothpastes, mouthrinse/mouthwash, tablets, and combination
methods. Mechanical debridement: for mechanical tongue cleaning versus no tongue
cleaning, the evidence was very uncertain for the outcome dentist-reported
organoleptic test (OLT) scores (MD -0.20, 95% CI -0.34 to -0.07; 2 trials, 46
reported OLT score or adverse events. Chewing gums: for 0.6% eucalyptus chewing gum
versus placebo chewing gum, the evidence was very uncertain for the outcome
dentist-reported OLT scores (MD -0.10, 950/0 CI -0.31 to 0.11; 1 trial, 65
reported OLT score or adverse events. Systemic deodori ing agents: for 1000 mg
champignon versus placebo, the evidence was very uncertain for the outcome patient-
reported visual analogue scale (VAS) scores (MD -1.07, 95% CI -14.51 to 12.37; 1
trial, 40 participants; very low-certainty evidence). No data were reported for
dentist-reported OLT score or adverse events. Topical agents: for hinokitiol gel
versus placebo gel, the evidence was very uncertain for the outcome dentist-
reported OLT scores (MD -0.27, 95% CI -1.26 to 0.72; 1 trial, 18 participants; very
adverse events. Toothpastes: for 0.3% triclosan toothpaste versus control
toothpaste, the evidence was very uncertain for the outcome dentist-reported OLT
scores (MD -3.48, 95% CI -3.77 to -3.19; 1 trial, 81 participants; very low-
certainty evidence). No data were reported for patient-reported OLT score or
adverse events. Mouthrinse/mouthwash: for mouthwash containing chlorhexidine and
zinc acetate versus placebo mouthwash, the evidence was very uncertain for the
outcome dentist-reported OLT scores (MD -0.20,95% CI -0.58 to 0.18; 1 trial, 44
reported OLT score or adverse events. Tablets: no data were reported on key
outcomes for this comparison. Combination methods: for brushing plus cetylpyridium
mouthwash versus brushing, the evidence was uncertain for the outcome dentist-
reported OLT scores (MD -0.48, 95% CI -0.72 to -0.24; 1 trial, 70 participants;
adverse events. Authors' conclusions We found low- to very low-certainty evidence
to support the effectiveness of interventions for managing halitosis compared to
placebo or control for the OLT and patient-reported outcomes tested. We were unable
to draw any conclusions regarding the superiority of any intervention or
concentration. Well-planned RCTs need to be conducted by standardising the
interventions and concentrations. PLAIN LANGUAGE SUMMARY Interventions for managing
bad breath Review question With this Cochrane Review we tried to find out the best
way to control bad breath, also called halitosis, due to a disease within the mouth
in adults. Background Bad breath or halitosis is caused by too much bacteria or
small food parts left inside the mouth, most commonly at the back of the tongue. It
can be a sign of a disease within the mouth or other body diseases. People with bad
breath can have low self-esteem and feel embarrassed. It can affect their personal
relationships and work. In this review, we looked at treatments for bad breath due
to a disease within the mouth and at treatments that aim to control not just mask
bad breath. Study characteristics This review is up-to-date as of 8 April 2019. The
review includes 44 studies involving 1809 people who were 17 to 77 years old. The
review compared an intervention with another intervention, a placebo or a control.
It looked at eight different ways to control bad breath: mechanical cleaning (e.g.
tongue cleaners and toothbrushes), chewing gums, systemic deodorising agents (e.g.
mushroom extract that you eat), topical agents (e.g. gel that you apply),
toothpastes, mouthrinse/mouthwash, tablets, and combination of different
treatments. Key results The evidence was very uncertain for mechanical tongue
cleaning versus no tongue cleaning, 0.6% eucalyptus chewing gum versus placebo
chewing gum, 1000 mg mushroom extract versus placebo, hinokitiol gel versus placebo
gel, 0.3% triclosan toothpaste versus control toothpaste, mouthwash containing
chlorhexidine and zinc acetate versus placebo mouthwash, and brushing plus
cetylpyridium mouthwash versus brushing. Harmful effects of the different
interventions were not reported or were not important. Certainty of the evidence
The level of certainty we have in these findings is Low to very low. This was due
mainly to risk of bias and the small number of people studied in the included
trials. Conclusion We do not have enough evidence to say which intervention works
better to control bad breath.
AN - rayyan-563562635
AU - Nagraj, S. K.
AU - Eachempati, P.
AU - Uma, E.
AU - Singh, V. P.
AU - Ismail, N. M.
AU - Varghese, E.
DO - 10.1002/14651858.CD012213.pub2
IS - 12
PY - 2019
SN - ["1469-493X", "1361-6137"]
ST - Interventions for managing halitosis (Review)
T2 - COCHRANE DATABASE OF SYSTEMATIC REVIEWS
TI - Interventions for managing halitosis (Review)
ID - 16009
ER -
TY - JOUR
AB - This paper introduces a novel type of injectable temperature-sensitive
chitosan polymer based in situ gel for the local delivery of Satranidazole into the
infected periodontal pocket. The thermo gelling polymer, chitosan with different
concentrations has been used for formulation of in situ gel of Satranidazole with
10 % propylene glycol as plasticizer and was allowed to cross linked with 1 %
solution of glutaraldehyde for extended release. The FTIR studies and the XRD
studies confirmed the absence of chemical interaction between the drug and the
polymer. The developed formulations were evaluated for various parameters like
surface pH, gelation temperature, drug content, spreadability, viscosity, in vitro
drug release and in vitro antibacterial activity, SEM and stability studies. The
optimized formulation G6 in terms of cumulative percent drug release along with
zero order kinetic mechanism with 98.6 % drug release for 5 days and fulfilled many
requirements of once a week delivery system. Throughout the permeation study, the
average permeation rate for in situ gel was found to be above the minimum
inhibitory concentration of Satranidazole indicating the suitability of formulating
Satranidazole as a controlled release local delivery in situ gel for longer periods
of time. Histopathological and microscopic study of the periodontal mucosa after
permeation study suggested that the gel formulations were safe for local anti
microbial treatment in to the infected periodontal pocket. The in vitro
antibacterial activity demonstrated a significant antibacterial profile of the in
situ gel G6 formulation against Porphyromonas gingivalis. The SEM of in situ gel
suggesting that the drug(s) were dispersed rather than dissolved in the polymer
matrix. The stability studies confirmed that the in situ gel formulation of
Satranidazole remained stable at room temperature (30 ± 2°C) and refrigerator
temperature (4 ± 2°C).
AN - rayyan-563560442
AU - Nair, R. V.
AU - Nair, S. C.
DO - 10.7897/2230-8407.050580
IS - 5
KW - chitosan
satranidazole
animal tissue
article
basement membrane
bovine
comparative study
controlled study
cross linking
drug formulation
drug mixture
drug release
drug solubility
gelation
histopathology
hydrogen bond
in vitro study
kinetics
mucosa
nonhuman
periodontal pocket
pH
temperature
viscosity
X ray diffraction
LA - English
PY - 2014
SN - 2230-8407
SP - 384-391
ST - Cross linked chitosan in situ gel of Satranidazole for intra periodontal drug
delivery
TI - Cross linked chitosan in situ gel of Satranidazole for intra periodontal drug
delivery
VL - 5
ID - 13816
ER -
TY - JOUR
AB - Abstract: The development of natural biomaterials applied for hard tissue
repair and regeneration is of great importance, especially in societies with a
large elderly population. Self-assembled peptide hydrogels are a new generation of
biomaterials that provide excellent biocompatibility, tunable mechanical stability,
injectability, trigger capability, lack of immunogenic reactions, and the ability
to load cells and active pharmaceutical agents for tissue regeneration. Peptide-
based hydrogels are ideal templates for the deposition of hydroxyapatite crystals,
which can mimic the extracellular matrix. Thus, peptide-based hydrogels enhance
hard tissue repair and regeneration compared to conventional methods. This review
presents three major self-assembled peptide hydrogels with potential application
for bone and dental tissue regeneration, including ionic self-complementary
peptides, amphiphilic (surfactant-like) peptides, and triple-helix (collagen-like)
peptides. Special attention is given to the main bioactive peptides, the role and
importance of self-assembled peptide hydrogels, and a brief overview on molecular
simulation of self-assembled peptide hydrogels applied for bone and dental tissue
engineering and regeneration. Graphic abstract: [Figure not available: see
fulltext.]
AN - rayyan-563559930
AU - Najafi, H.
AU - Jafari, M.
AU - Farahavar, G.
AU - Abolmaali, S. S.
AU - Azarpira, N.
AU - Borandeh, S.
AU - Ravanfar, R.
DO - 10.1007/s42242-021-00149-0
IS - 4
blood clotting factor 13a
calcitonin gene related peptide
calcium phosphate
cell penetrating peptide
collagen
collagen type 1
elastin
endoglin
hydrogel
surfactant
testosterone
vasculotropin
zinc chloride
amino acid sequence
attention
biocompatibility
biomechanics
bone conduction
bone development
bone maturation
bone regeneration
bone remodeling
bone tissue
cell proliferation
fracture healing
gene expression
human
MAPK signaling
microenvironment
molecular dynamics
nonhuman
odontoblast
osseointegration
osteoblast
osteoprogenitor cell
peptide synthesis
periodontal disease
protein secondary structure
review
signal transduction
tissue engineering
tissue regeneration
tissue repair
tooth injury
triple helix
upregulation
LA - English
PY - 2021
SN - ["2522-8552", "2096-5524"]
SP - 735-756
ST - Recent advances in design and applications of biomimetic self-assembled
peptide hydrogels for hard tissue regeneration
T2 - Bio-Des. Manufact.
TI - Recent advances in design and applications of biomimetic self-assembled
peptide hydrogels for hard tissue regeneration
VL - 4
ID - 13304
ER -
TY - JOUR
AB - Objectives: Complete elimination of the pathogenic microorganisms from the
gingival sulcus area is the ultimate goal of any periodontal therapy. Certain
factors such as anatomical variation of teeth, deep periodontal pocket, and tissue-
invading ability of some bacteria decrease the effectiveness of conventional
nonsurgical periodontal therapy, i.e., scaling and root planing (SRP). Hence,
antimicrobial agents could be used as an adjunct to SRP, in order to increase the
efficacy of it. Although Chlorhexidine (CHX) is the gold standard as an antiplaque
agent, it has several drawbacks. Recently, ozone therapy is being tried for the
treatment of several diseases in the field of dentistry. Therefore, the purpose of
this study was to evaluate and compare the efficacy of local application of CHX and
ozonated olive oil as adjunctive to SRP for the treatment of chronic periodontitis.
Materials and Methods: Thirty individuals who fulfilled the eligibility criteria
were selected for this split-mouth randomized controlled trial. The treatment sites
from each individual were randomly allocated into two groups. Along with SRP, the
local application of CHX and ozonated olive oil was done for the control and test
sites, respectively. Pocket probing depth, relative attachment loss, and sulcus
bleeding index were measured before and 3 months after the treatment. Intragroup
and intergroup differences in the clinical parameters were analyzed by Wilcoxon
signed-rank test and Mann-Whitney U test, respectively. Results: Three months'
posttreatment, all the parameters showed significant improvement in both the
groups. However, the intergroup comparison failed to be significant statistically.
Conclusion: Ozonated olive oil could enhance the outcomes of SRP for the treatment
AN - rayyan-563559829
AU - Nambiar, S.
AU - Malothu, S.
AU - Karmakar, S.
AU - Varkey, A.
AU - Chandra, D.
AU - Chava, V. K.
DO - 10.4103/jpbs.jpbs-565-21
IS - 5
KW - dental ultrasound system
EMS Piezon ultrasonic system
periodontal probe
Supragingival
antiinfective agent
chlorhexidine
gel
hexigel
olive oil
puro 3llc
adult
article
clinical article
clinical protocol
comparative study
controlled study
dental parameters
dental scaling
human
ozone therapy
root planing
scaling and root planing
LA - English
PY - 2022
SN - 0975-7406
SP - S94-S98
ST - Comparison of ozonated olive oil and chlorhexidine gel as an adjunct to
nonsurgical periodontal therapy for the treatment of chronic periodontitis: A
TI - Comparison of ozonated olive oil and chlorhexidine gel as an adjunct to
nonsurgical periodontal therapy for the treatment of chronic periodontitis: A
VL - 14
ID - 13203
ER -
TY - JOUR
AB - Background: Periodontitis is an inflammatory disease caused by gramnegative
periodontopathic bacteria which can lead to loss of tooth-supporting structures and
alveolar bone resorption.Wnt signalingmolecules play important roles in bone
biology, apoptosis and chronic inflammation. Recent studies have suggested an
association of these molecules with various disorders including cardiovascular
diseases, rheumatoid arthritis, and osteoarthritis. We previously demonstrated that
Wnt5a mRNA expression was up-regulated in chronic periodontitis tissue when
compared to non-periodontitis tissue. In this study, we investigated the modulation
of Wnt5a mRNA expression by periodontopathic bacteria. Methods: Human monocytic
cell line THP-1 were stimulated with Porphyromonas gingivalis (P. gingivalis) LPS,
Escherichia coli (E. coli) LPS, IL-6, IFN-β, or IFN-γ. To investigate the
involvement of NF-κB and JAK/STAT pathways in the modulation of Wnt5a expression,
techniques were used including inhibition assay, transfection, western blotting,
luciferase assay and EMSA. The levels of Wnt5a mRNA were determined by real-time
RT-PCR. Results: In THP-1 cells, Wnt5a expression was significantly up-regulated by
P. gingivalis LPS than E. coli LPS. P. gingivalis LPS induced Wnt5a mRNA expression
and NF-κB activity. P. gingivalis LPS markedly reduced the cytosolic level of IκBα
than E. coli LPS. The induction of Wnt5a mRNA expression was augmented by co-
stimulation with IFN-γ and overexpression of STAT1, but it was suppressed by STAT1
siRNA. Conclusion: IFN-γ synergistically enhanced the P. gingivalis LPS induced
Wnt5a expression through STAT1 in parallel with the activation of NF-κB. These
findings will help reveal the mechanism of molecular pathogenesis of periodontal
disease.
AN - rayyan-563560593
AU - Nanbara, H.
AU - Wara-aswapati, N.
AU - Yoshida, Y.
AU - Nagasawa, T.
AU - Yashiro, R.
AU - Bando, Y.
AU - Kobayashi, H.
AU - Boch, J. A.
AU - Izumi, Y.
DO - 10.1007/s00011-011-0341-6
KW - STAT1 protein
lipopolysaccharide
messenger RNA
interleukin 6
luciferase
inflammation
Escherichia coli
tissues
periodontitis
modulation
bacterium
assay
periodontal disease
tooth
alveolar bone
bone
apoptosis
diseases
osteoarthritis
human
cell line
Western blotting
stimulation
molecular pathology
LA - English
PY - 2011
SN - 1023-3830
SP - S161-S162
ST - Wnt5a expression by porphyromonas gingivalis lps via NF-κb and stat1
T2 - Inflamm. Res.
TI - Wnt5a expression by porphyromonas gingivalis lps via NF-κb and stat1
VL - 60
ID - 13967
ER -
TY - JOUR
AB - Background: Local drug delivery to gingival sulcus avoids adverse effects
seen with systemic therapy and there is very little information to substantiate the
additive effect of the drugs, the current study makes an attempt in same regard.
Aim: The objective of this study was to compare the local application of ornidazole
and chlorhexidine gel (Clorni™ gel) as an adjunct to scaling and polishing, with
scaling and polishing alone. Materials and methods: 33 patients meeting inclusion
criteria were randomly allocated to treatment groups by computerized randomly
selection method. Indices were recorded at baseline at their first visit.
Supragingival and subgingival scaling and polishing was performed using hand and
ultrasonic instruments. The patients were evaluated clinically by using the
gingival index, plaque index and modified sulcus bleeding index. On test side,
Clorni™ gel was applied subgingivally after nonsurgical periodontal therapy. On the
control side, no intervention was done following subgingival scaling and polishing.
Patients were recalled at 7th day for subsequent administration of gel on the same
site and followed up at 21st day and 3 months to compare the gingival condition by
using the indices. Results: All subjects showed significant improvement over 3
months recall period, irrespective of test or controls. Statistical significance (p
0.05) was observed at 7 days and 21 days for test group for the gingival index and
at 21 days for the plaque index and modified sulcus bleeding index. Conclusion: The
topical gel when used as an adjunct to scaling and polishing had significant
results.
AN - rayyan-563560086
AU - Narayanan, R.
AU - Prabhuji, M. L. V.
AU - Bhavikatti, S. K.
AU - Saquib, S. A.
AU - Paramashivaiah, R.
AU - Karobari, M. I.
AU - Ustad, F.
DO - 10.37506/ijfmt.v14i4.12322
IS - 4
KW - chlorhexidine
clorni
ornidazole
adult
article
clinical article
clinical evaluation
controlled study
dental scaling
female
gingival index
gingival tissue
gingivitis
human
male
parallel design
plaque index
root planing
LA - English
PY - 2020
SN - ["0973-9130", "0973-9122"]
SP - 4346-4353
ST - Clinical evaluation of local drug delivery of chlorhexidine and ornidazole in
the treatment of gingivitis as an adjunct to scaling and root planing
TI - Clinical evaluation of local drug delivery of chlorhexidine and ornidazole in
the treatment of gingivitis as an adjunct to scaling and root planing
VL - 14
ID - 13460
ER -
TY - JOUR
AB - AIM: The aim of the present study was to evaluate the effects of a
chlorhexidine brush-on gel application on plaque-induced gingivitis. MATERIALS &
METHODS: Consecutive patients diagnosed with gingivitis were enrolled. For each
patient, full mouth plaque score and gingival index were recorded during the first
visit (t0) and after 1 week (t1), 2 weeks (t2) and 3 weeks (t3). Patients were
randomly divided into a study group, who received instruction to brush their teeth
daily with a chlorhexidine-based gel, and a control group, treated with a placebo
gel. The chi-square test was used to compare the groups baseline, while the t-
Student and the Mann-Whitney tests were performed to evaluate the significance of
groups indexes improvement, individually and compared. RESULTS: Thirty participants
were enrolled: 15 referred to the study group and 15 to the control group. The
study group showed a reduction of plaque score and gingival index of 87% and 84%
respectively (p<0.05), while the control group plaque score and gingival index
decreased of 75% and 80% (p<0.05). The study group plaque score reduction resulted
to be statistically more significant than the control group one. CONCLUSIONS: The
topical application of a chlorhexidine-based brush-on gel can be a useful
adjunctive domiciliary treatment for gingivitis therapy, combined with the
mechanical debridement, that still remains the gold standard.
AN - rayyan-563560169
AU - Nardi, G. M.
AU - Grassi, R.
AU - Campus, G.
AU - Pareti, M. L.
AU - Di Stasio, D.
AU - Della Vella, F.
DO - 10.2174/1568026619666191114120218
KW - adult
article
clinical article
controlled study
drug therapy
female
gingival index
gingivitis
gold standard
human
male
mouth hygiene
mouth plaque
rank sum test
adjuvant
chlorhexidine
placebo
LA - English
PY - 2019
SN - 1873-4294
ST - A chlorhexidine-containing brush-on gel as adjuvant treatment for plaque
induced gingivitis
T2 - Curr Top Med Chem
TI - A chlorhexidine-containing brush-on gel as adjuvant treatment for plaque
induced gingivitis
ID - 13543
ER -
TY - JOUR
AB - The novel solvent-free process to formulate long-acting microparticles of
tetracycline hydrochloride (TH) using hot melt extrusion granulation process
coupled with size reduction using comil for the treatment of periodontitis was
investigated using hydrogenated castor oil (HCO) as hydrophobic matrix former. The
microparticles were characterized for micromeritics, drug diffusion, SEM studies,
and stability analysis by DSC, FTIR, and proton NMR. Xanthan gum gel was used as
delivery vehicles to administer microparticles inside periodontal pockets. The
microparticles were sterilized using gamma radiation; delivery vehicle was
sterilized using gamma radiation and autoclave process. Microparticles were
evaluated for microbial load as per compendial guidelines. Optimized composition
was evaluated for clinical parameters such as plaque index, gingival index, probing
pocket depth, and clinical attachment level. Based on the statistical analysis of
the data, the micromeritic properties and drug diffusion profiles vary based on the
concentration of HCO in the formulation. SEM images reflect the surface properties
prior and post drug diffusion studies, which indicates that release takes place
predominantly by diffusion of TH through HCO matrix. DSC studies indicate no change
in the respective spectra of initial and stability samples. FTIR studies indicate
possibility of hydrogen bonding. Proton NMR data suggests characteristic peaks of
TH being retained in the stability samples, indicating stable composition. Gamma
radiation has led to significant reduction in viscosity of xanthan gum solution
over autoclave. Clinical studies indicated statistical improvements in the
formulation compared to baseline results, indicating the efficacy of the
formulation in the treatment of periodontitis.
AN - rayyan-563559977
AU - Narkhede, R.
AU - Athawale, R.
AU - Patil, N.
AU - Baburaj, M. D.
DO - 10.1208/s12249-021-02037-3
IS - 5
KW - hydrogenated castor oil
tetracycline
xanthan
article
clinical assessment
controlled study
drug diffusion
drug formulation
drug granulation
gamma radiation
gingival index
hot melt extrusion
human
hydrogen bond
nonhuman
periodontitis
plaque index
surface property
LA - English
PY - 2021
SN - 1530-9932
ST - Formulation, Evaluation, and Clinical Assessment of Novel Solid Lipid
Microparticles of Tetracycline Hydrochloride for the Treatment of Periodontitis
TI - Formulation, Evaluation, and Clinical Assessment of Novel Solid Lipid
Microparticles of Tetracycline Hydrochloride for the Treatment of Periodontitis
VL - 22
ID - 13351
ER -
TY - JOUR
AB - Interleukin-6 (IL-6) binds to human gingival fibroblasts (HGF) in the
presence of a soluble form of IL-6 receptor (sIL-6R). We investigated the effects
of IL-6 on the functions of HGF in the presence of sIL-6R. HGF changed their
morphology from spindle-shaped to round, and detached from the culture dish by
stimulation with IL-6/sIL-6R. In this condition, a signal transducer gp130 and a
transcription factor Stat3 were phosphorylated, resulting in activation of
transcription factors Stat3 and C/EBPβ. Cytoskeletal β-actin and adhesion molecule
integrin-α5, a subunit of α5β1 integrin (VLA-5), were found to possess potential
binding domains for these transcription factors in their promoters. Accumulation of
β-actin and integrin-α5 mRNA decreased, contrary to the expectation of the
induction of gene transcription. Furthermore, the decrease in their mRNAs was
associated with reduced expression of both actin and VLA-5 proteins. These results
suggest that the expression of VLA-5 and actin was down-regulated in HGF through an
IL-6 signaling pathway, resulting in impairment of HGF adherence.
AN - rayyan-563560921
AU - Naruishi, K.
AU - Takashiba, S.
AU - Nishimura, F.
AU - Chou, H. H.
AU - Arai, H.
AU - Yamada, H.
AU - Murayama, Y.
DO - 10.1177/00220345010800050701
IS - 5
KW - actin
cell adhesion molecule F11
DNA binding protein
fibronectin receptor
fusion protein
interleukin 6
interleukin 6 interleukin 6 receptor fusion protein, recombinant
interleukin 6-interleukin 6 receptor fusion protein, recombinant
interleukin receptor
nerve cell adhesion molecule
recombinant protein
STAT3 protein
STAT3 protein, human
transactivator protein
amino acid sequence
article
biosynthesis
cell adhesion
cell culture
cytology
down regulation
drug effect
fibroblast
gingiva
gingivitis
human
metabolism
molecular genetics
phosphorylation
physiology
protein binding
signal transduction
Western blotting
LA - English
PY - 2001
SN - 0022-0345
SP - 1421-1424
ST - Impairment of gingival fibroblast adherence by IL-6/sIL-6R
T2 - J. Dent. Res.
TI - Impairment of gingival fibroblast adherence by IL-6/sIL-6R
VL - 80
ID - 14295
ER -
TY - JOUR
AB - This study aimed to develop syringeable in-situ curcumin (cur) gel for the
treatment of periodontal pockets as well as to evaluate the clinical efficacy of
Cur in-situ gel formulation. Different in-situ gel formulations of Cur were
prepared using 30% of pluronic F127, and 1% of carbopol P934. The formulations were
evaluated regarding gelation temperature, pH, viscosity, syringeability study, in-
vitro release and chemical stability of cur. The effect of aging of gel
formulations for 3months in refrigerator was investigated. The selected formulation
was clinically evaluated through the determination of probing depth, plaque index,
and bleeding index at baseline and 1 month after application. The formulations
showed accepted gelation temperature ranging from 28 to 34 ˚C and all had pH value
of 4. The viscosity of the formulations at 4 ˚C ranged from 19 000 to 37 000 cP.
All formulations were easily syringeable through 21 gauge needle at cold
temperature. Curcumin stability during the release study was maintained. Aging
showed no significant effect on release profile, drug content, or the pH after 3
months, while it showed a slight increase in viscosity with concomitant decrease in
gelation temperature. Selected formulations delivered into periodontal pocket
evaluated clinically showed to be effective. The treated group revealed that the
adjunctive use of intracrevicular 2% curcumin in-situ gel adjunct to mechanical
treatment in patients with adult periodontitis could aid in significant clinical
reduction of probing depth, bleeding index, and to less extent of plaque. This
indicates that curcumin in this novel drug delivery system is an excellent
candidate for periodontal disease treatment.
AN - rayyan-563560309
AU - Nasra, M. M. A.
AU - Khiri, H. M.
AU - Hazzah, H. A.
AU - Abdallah, O. Y.
DO - 10.1080/10717544.2016.1233591
IS - 1
KW - alcohol
carbomer
curcumin
curcumin in situ gel
distilled water
poloxamer
unclassified drug
adult
article
bleeding
body temperature
clinical article
cold
controlled study
drug efficacy
drug formulation
drug screening
drug solubility
drug stability
female
gelation
gingivitis
human
in vitro study
male
mouth hygiene
patient compliance
periodontal pocket
pH
physical parameters
plaque index
precipitation
priority journal
probing depth
room temperature
solubilization
syringeability
viscosity
LA - English
PY - 2017
SN - ["1521-0464", "1071-7544"]
SP - 133-142
ST - Formulation, in-vitro characterization and clinical evaluation of curcumin
in-situ gel for treatment of periodontitis
T2 - Drug Deliv.
TI - Formulation, in-vitro characterization and clinical evaluation of curcumin
in-situ gel for treatment of periodontitis
VL - 24
ID - 13683
ER -
TY - JOUR
AB - BACKGROUND: Several locally administered antimicrobials have been studied in
the literature as adjunctive or primary treatments for periodontitis and peri-
implantitis with conflicting results. OBJECTIVE: The aim of this study was twofold:
(1) the formulation of a controlled-release material containing metronidazole and
doxycycline; (2) an in vitro evaluation of its antibacterial properties against
planktonic and biofilm species involved in periodontal and peri-implant diseases.
METHODS: Doxycycline (10 mg/ml) and metronidazole (20 mg/ml) were incorporated into
a hydroxyethylcellulose-polyvinylpyrrolidone-calcium polycarbophil gel. Three
milliliters of gel were dialyzed against Dulbecco's phosphate-buffered saline for
13 days. Antibiotics release at 3, 7, 10, and 13 days was determined
spectroscopically. The inhibitory activity of the experimental gel was tested
against A. actinomycetemcomitans, S. sanguinis, P. micra, and E. corrodens with an
agar diffusion test, an inactivation biofilm test, and a confocal laser scanning
microscope study (CLSMS) for S. sanguinis up to 20 days. RESULTS: After 13 days, the
released doxycycline was 9.7% (at 3 days = 1.2 mg; 7 days = 0.67 mg; 10 days = 0.76 mg; 13
days = 0.29 mg), while metronidazole was 67% (30 mg, 6.8 mg, 2.5 mg, and 0.9 mg at the
same intervals). The agar diffusion test highlights that the formulated gel was
active against tested microorganisms up to 312 h. Quantitative analysis of biofilm
formation for all strains and CLSMS for S. sanguinis showed a high growth reduction
up to 13 days. CONCLUSIONS: The in vitro efficacy of the newly formulated gel was
confirmed both on planktonic species and on bacterial biofilm over a period of 13
days. The controlled-release gel containing metronidazole and doxycycline had an
optimal final viscosity and mucoadhesive properties. It can be argued that its
employment could be useful for the treatment of periodontal and peri-implant
diseases, where conventional therapy seems not successful.
AN - rayyan-563561091
AU - Nastri, L.
AU - De Rosa, A.
AU - De Gregorio, V.
AU - Grassia, V.
AU - Donnarumma, G.
DO - 10.1155/2019/9374607
J2 - Int J Dent
LA - eng
N1 - Multidisciplinary Department of Medical-Surgical and Odontostomatological
Specialties, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.;
Multidisciplinary Department of Medical-Surgical and Odontostomatological
Specialties, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.;
Center for Advanced Biomaterials for HealthCare@CRIB, Istituto Italiano di
Tecnologia, Largo Barsanti e Matteucci 53, 80125 Naples, Italy.; Multidisciplinary
Department of Medical-Surgical and Odontostomatological Specialties, University of
Campania "Luigi Vanvitelli", 80100 Naples, Italy.; Department of Experimental
Medicine, Section of Microbiology and Clinical Microbiology, University of Campania
"Luigi Vanvitelli", 80100 Naples, Italy.
PY - 2019
SN - 1687-8728 (Print)
SP - 9374607
ST - A New Controlled-Release Material Containing Metronidazole and Doxycycline
for the Treatment of Periodontal and Peri-Implant Diseases: Formulation and In
Vitro Testing
T2 - International journal of dentistry
TI - A New Controlled-Release Material Containing Metronidazole and Doxycycline
for the Treatment of Periodontal and Peri-Implant Diseases: Formulation and In
Vitro Testing
VL - 2019
ID - 14465
ER -
TY - JOUR
AB - Controlled drug release formulations are rapidly gaining importance in drug
therapy as replacements for conventional systemic dosages. Examples include skin
patches for treatment of angina pectoris and motion sickness, eye inserts for
glaucoma and implants for prolonged release of contraceptives. This paper will
review the current status of periodontal controlled release devices and look at
their potential role in periodontal treatment.
AN - rayyan-563561161
AU - Needleman, I. G.
IS - 11
chlorhexidine
tetracycline
gel
human
periodontal disease
review
LA - English
PY - 1991
SN - 0007-0610
SP - 405-408
ST - Controlled drug release in periodontics: a review of new therapies
T2 - Br Dent J
TI - Controlled drug release in periodontics: a review of new therapies
VL - 170
ID - 14535
ER -
TY - JOUR
AB - Objectives: The aim of this 12-month, randomised controlled, single-blind,
parallel-arm study, was to test whether local application of a slow-release
antimicrobial might exert an adjunctive effect on healing following periodontal
surgery. Materials and Methods: Following non-surgical therapy, 43 patients with
moderate to advanced periodontitis, had at least 1 pocket greater than or equal to
6 mm with bleeding on probing (BOP). Treatment consisted of modified Widman surgery
with no osseous resection. The test group (T) received gel application over the
exposed root surface and the control group (C) received no gel, followed by flap
closure. Results: 38 patients completed the study: 5 patients did not attend at 12
months and could not be traced. Surgery was very successful in both groups in
improving probing depths (mean baseline: T=7.4 mm, C=7.1 mm; 12 months T=3.7 mm,
C=3.5 mm) and relative attachment levels (baseline: T=10.3 mm, C=10.1 mm; 12 months
T=8.2 mm, C=8.8 mm). Differences between groups were not significant at 12 months,
although the improvements within groups between baseline and 12 months were highly
statistically significant (p<0.01). Plaque and BOP levels were low in both groups
after treatment. Conclusion: MWF surgery was effective in establishing the
periodontal health of sites with advanced disease and this study was unable to
detect an additional benefit to using a 25% metronidazole gel.
AN - rayyan-563562050
AU - Collins, A. M.
AU - Moles, D. R.
DO - 10.1034/j.1600-051x.2000.027003187.x
IS - 3
PY - 2000
SN - 0303-6979
SP - 187-192
ST - Periodontal flap surgery with 25% metronidazole gel (1). Clinical outcomes
TI - Periodontal flap surgery with 25% metronidazole gel (1). Clinical outcomes
VL - 27
Y2 - 3
ID - 15424
ER -
TY - JOUR
AB - OBJECTIVES: The aim of this 12-month, randomised controlled, single-blind,
parallel-arm study, was to test whether local application of a slow-release
antimicrobial might exert an adjunctive effect on healing following periodontal
surgery. MATERIALS AND METHODS: Following non-surgical therapy, 43 patients with
moderate to advanced periodontitis, had at least 1 pocket > or =6 mm with bleeding
on probing (BOP). Treatment consisted of modified Widman surgery with no osseous
resection. The test group (T) received gel application over the exposed root
surface and the control group (C) received no gel, followed by flap closure.
RESULTS: 38 patients completed the study: 5 patients did not attend at 12 months
and could not be traced. Surgery was very successful in both groups in improving
probing depths (mean baseline: T=7.4 mm, C=7.1 mm; 12 months T=3.7 mm, C=3.5 mm)
and relative attachment levels (baseline: T=10.3 mm, C=10.1 mm; 12 months T=8.2 mm,
C=8.8 mm). Differences between groups were not significant at 12 months, although
the improvements within groups between baseline and 12 months were highly
statistically significant (p<0.01). Plaque and BOP levels were low in both groups
after treatment. CONCLUSION: MWF surgery was effective in establishing the
periodontal health of sites with advanced disease and this study was unable to
detect an additional benefit to using a 25% metronidazole gel.
AN - rayyan-563560991
AU - Collins, A. M.
AU - Moles, D. R.
IS - 3
metronidazole
adult
aged
article
clinical trial
comparative study
confidence interval
controlled study
drug effect
follow up
gel
gingiva bleeding
human
middle aged
periodontal disease
periodontitis
plastic surgery
reproducibility
tooth plaque
tooth root
treatment outcome
wound healing
LA - English
PY - 2000
SN - 0303-6979
SP - 187-192
ST - Periodontal flap surgery with 25% metronidazole gel. (1). Clinical outcomes
TI - Periodontal flap surgery with 25% metronidazole gel. (1). Clinical outcomes
VL - 27
ID - 14365
ER -
TY - JOUR
AN - rayyan-563562211
AU - Collins, A. M.
AU - Moles, D. R.
DO - 10.1034/j.1600-051x.2000.027003187.x
IS - 3
PY - 2000
SP - 187-192
ST - Periodontal flap surgery with 25% metronidazole gel: (1). Clinical outcomes
TI - Periodontal flap surgery with 25% metronidazole gel: (1). Clinical outcomes
0034146156&doi=10.1034%2fj.1600-
051x.2000.027003187.x&partnerID=40&md5=8e34ac474667938373d850902d4499c0
VL - 27
ID - 15585
ER -
TY - JOUR
AB - This randomized, examiner masked, split mouth study evaluated a new model to
test periodontal therapy involving a novel bioerodible copolymer gel containing
tetracycline hydrochloride. Responses to the tetracycline gel and untreated control
were compared for product tolerance and 3 different measures of effectiveness (drug
retention, changes in microbial levels, and clinical status). The test gel was
administered by syringe into the periodontal pockets of 18 systemically healthy
adult volunteers, each of whom presented with 3 or more sites with 6 mm probing
depths. Gingival crevicular fluid samples were used to monitor daily drug levels
over 7 days, while clinical responses were assessed at day 30. Overall, the test
gel was well-tolerated by all patients. For the 3 effectiveness measures,
tetracycline was released throughout the observation period and mean levels
exceeded 100 microg/mL over 6 days, statistically significant reductions in
selected periodontal pathogens were evident at day 7 but not at day 30, and mean
probing depth reductions at test sites were 1.12 mm at 30 days versus 0.36 mm at
untreated control sites (P=0.012). The safety profile, longer-term drug retention,
antimicrobial activity, and clinical response in this Phase I study suggest that
this tetracycline-containing copolymer gel platform may represent a safe and
effective bioerodible therapy for periodontitis. The experimental model also shows
merit for early phase clinical testing of novel therapeutic agents.
AN - rayyan-563560965
AU - Gerlach, R. W.
AU - Baker, R. A.
AU - Damani, N. C.
AU - Smith, S. R.
AU - Smales, F. C.
DO - 10.1902/jop.1998.69.5.578
IS - 5
J2 - J Periodontol
Adult
Aged
Anti-Bacterial Agents/*administration & dosage/analysis
Drug Carriers
Female
Gels
Gingival Crevicular Fluid/chemistry
Humans
Linear Models
Male
Middle Aged
Single-Blind Method
Tetracycline/*administration & dosage/analysis
LA - eng
N1 - Department of Periodontology, Eastman Dental Institute, London, UK.
PY - 1998
SN - 0022-3492 (Print)
SP - 578-83
ST - Retention, antimicrobial activity, and clinical outcomes following use of a
bioerodible tetracycline gel in moderate-to-deep periodontal pockets
TI - Retention, antimicrobial activity, and clinical outcomes following use of a
bioerodible tetracycline gel in moderate-to-deep periodontal pockets
VL - 69
Y2 - 5
ID - 14339
ER -
TY - JOUR
AB - AIM: The aim of this study was to investigate a rapid spectrophotometric
assay for its potential to measure tetracycline levels in gingival crevicular fluid
(GCF). MATERIALS AND METHODS: The technique involves complexation of tetracycline
with molybdenum in order to shift the absorbance spectrum away from that region
where interference with plasma proteins is a problem. The sensitivity of the assay
and reproducibility of elution were examined together with an assessment of the
effect of plasma proteins. The assay was also tested in a small pilot clinical
project, measuring tetracycline levels in GCF following placement of a test gel
formulation in 25 periodontal pockets in 5 patients. RESULTS: The in vitro results
showed good sensitivity of the assay over the concentration range tested (0.5-200
microg tetracycline) and with little effect of plasma proteins. Elution from the
paper strips was reproducible with a good linear correlation between direct and
filter absorbed assays (r=0.9989, p<0.01). The pilot clinical study indicated a
mean half-time of tetracycline in GCF of 28 min with confidence intervals of 21 to
34 min, although wide variation between the drug levels of individual periodontal
pockets was seen. CONCLUSIONS: The results indicate good sensitivity for this assay
to measure tetracycline hydrochloride in vivo. The potential for rapidly processing
large numbers of samples contrasts with the assay time and limited sample
throughput of other methods such as high pressure liquid chromatography (HPLC) and
suggests that the technique may be a useful addition to current techniques for
measuring tetracycline hydrochloride in vivo.
AN - rayyan-563560928
AU - Grahn, M. F.
AU - Pandya, N. V.
IS - 1
molybdenum
plasma protein
tetracycline
article
calibration
chemistry
gingivitis
human
methodology
reproducibility
spectrophotometry
statistical model
validation study
LA - English
PY - 2001
SN - 0303-6979
SP - 52-56
ST - A rapid spectrophotometric assay for tetracycline in gingival crevicular
fluid
TI - A rapid spectrophotometric assay for tetracycline in gingival crevicular
fluid
VL - 28
ID - 14302
ER -
TY - JOUR
AB - OBJECTIVES: The aim of this study was to examine the effect of periodontal
surgery on PGE2 levels in patients treated for advanced adult periodontitis, with
and without application of a 25% metronidazole gel over 12 months follow-up.
MATERIAL AND METHODS: The trial employed a randomised controlled, single-blind,
parallel arm design on 43 patients with at least 1 pocket probing > or =6 mm with
bleeding on probing (BOP). RESULTS: The results showed that GCF PGE2 levels showed
no significant change following surgical therapy despite marked improvements in
clinical periodontal health (p=0.653). No significant differences in the reaction
of sites to treatment were detected between test and control groups throughout the
study (p=0.709). However, PGE2 levels in GCF were significantly higher in
experimental sites compared with healthy untreated sites (negative controls) in
both surgery only (p= 0.001) and surgery+gel (p=0.023) groups throughout the study.
CONCLUSION: Whilst clear differences were observed between healthy control sites
and sites with periodontal breakdown, no effect of treatment on PGE2 levels was
discernible in this study.
AN - rayyan-563560992
AU - Moles, D. R.
AU - Collins, A. M.
IS - 3
metronidazole
prostaglandin E2
adult
article
chemistry
clinical trial
comparative study
confidence interval
controlled study
follow up
gel
gingiva bleeding
gingivitis
human
periodontal disease
periodontitis
plastic surgery
LA - English
PY - 2000
SN - 0303-6979
SP - 193-197
ST - Periodontal flap surgery with 25% metronidazole gel. (2). Effect on gingival
crevicular fluid PGE2
TI - Periodontal flap surgery with 25% metronidazole gel. (2). Effect on gingival
crevicular fluid PGE2
VL - 27
ID - 14366
ER -
TY - JOUR
AB - Since last reviewing the field, controlled release products have made the
jump from research to clinical practice. The potential to extend the efficacy of
periodontal therapy with such products is exciting, but also needs careful
evaluation. This review will look at recent developments and also will examine the
eventual place for these products in periodontics.
AN - rayyan-563561071
AU - Pandya, N. V.
AU - Smith, S. R.
AU - Foyle, D. M.
IS - 3
ethylenevinylacetate copolymer
metronidazole
minocycline
tetracycline
gel
human
patient care planning
patient selection
periodontitis
review
LA - English
PY - 1995
SN - 0965-7452
SP - 111-117
ST - The role of antibiotics in the treatment of periodontitis (Part 2--Controlled
drug delivery)
T2 - Eur J Prosthodont Restor Dent
TI - The role of antibiotics in the treatment of periodontitis (Part 2--Controlled
drug delivery)
VL - 3
ID - 14445
ER -
TY - JOUR
AN - rayyan-563561171
AU - Watts, T. L. P.
DO - 10.1902/jop.1989.60.12.699
IS - 12
KW - metronidazole
article
clinical article
human
microorganism
mouth flora
periodontitis
LA - English
PY - 1989
SN - 0022-3492
SP - 699-703
ST - The effect of 1% metronidazole gel in routine maintenance of persistent
furcation involvement in human beings
TI - The effect of 1% metronidazole gel in routine maintenance of persistent
furcation involvement in human beings
VL - 60
ID - 14545
ER -
TY - JOUR
AB - BACKGROUND: With the interest in the delivery of drugs to the periodontal
pocket has come an increased need to determine the loss of formulations from the
site of application. In this respect, gamma scintigraphy has been used to measure
formulation clearance in mucosal sites such as the oesophagus, nose and eyes by
assessing the persistence of an incorporated radiolabel. However, the technique has
not been used to follow clearance from the periodontal pocket. AIMS: The aim of
this study was therefore to assess the potential of gamma scintigraphy to follow
the loss of 2 contrasting formulations. 10% chitosan gel and normal saline. METHOD:
Technitium-99m was used as the radionuclide and was incorporated into the
formulations on the day of use. 9 subjects contributed up to 2 pockets for each
formulation with probing depths > or = 5 mm. RESULTS: The results demonstrated that
gamma scintigraphy was able to follow the loss of the radiolabel despite the small
volumes of formulation placed in situ. The mean (SD) times (min) for the original
counts to decline to 10%, 50% and 90% of the original values were: T10: chitosan
74.5 (59.0), saline 40.3 (21.1), T50: chitosan 41.5 (34.1) saline 20.8 (11.7) and
T90: chitosan 8.5 (10.8), saline 1.4 (3.7) respectively. Clearance times of the 2
formulations were significantly different from each other (p<0.05). CONCLUSION: In
conclusion, gamma scintigraphy is a sensitive method for assessing clearance from
the periodontal pocket, and further studies are merited to optimise the use of the
technique.
AN - rayyan-563560930
AU - Needleman, I.
AU - Mather, S. J.
AU - Martin, G. P.
AU - Sobnack, R.
IS - 12
KW - chitin
chitosan
drug derivative
pentetate technetium tc 99m
radiopharmaceutical agent
sodium chloride
adult
aged
article
evaluation study
human
metabolic clearance rate
metabolism
middle aged
nonparametric test
periodontitis
regression analysis
scintiscanning
LA - English
PY - 2000
SN - 0303-6979
SP - 904-909
ST - Periodontal pocket clearance by gamma scintigraphy in human volunteers
TI - Periodontal pocket clearance by gamma scintigraphy in human volunteers
VL - 27
ID - 14304
ER -
TY - JOUR
AN - rayyan-563562120
AU - Newbrun, E.
DO - 10.1111/j.1741-2358.1986.tb00381.x
IS - 1
PY - 1986
SP - 33-41
ST - Prevention of Root Caries
T2 - Gerodontology
TI - Prevention of Root Caries
0022672234&doi=10.1111%2fj.1741-
2358.1986.tb00381.x&partnerID=40&md5=daf147f68dfa1854b4119b39fb0d2ed1
VL - 5
ID - 15494
ER -
TY - JOUR
AB - Prevention of dental caries in patients with hyposalivation due to Sjögren's
syndrome requires increasing host resistance and decreasing cariogenic organisms
and their substrate. Although plaque control by scrupulous oral hygiene is
important, particularly from a periodontal perspective, and restriction of dietary
sucrose intake can limit caries, the most successful therapeutic and preventive
measure has been the topical application of fluoride to the tooth surface, by the
dentist, dental hygienist, dental auxiliary, and the patient. Studies on
schoolchildren with normal salivary function who used fluoride dentifrices have
shown that efficacy in caries prevention depends on (1) the concentration of
fluoride used, (2) the frequency with which it is applied, and, to a certain
extent, (3) the specific fluoride compound used. Controlled clinical studies are
lacking, however, on patients with hyposalivation due to Sjögren's syndrome, and
only limited data are available from patients with radiation-induced
hyposalivation. Obviously it is not possible to run placebo control groups;
nevertheless, there have been no head-to-head comparisons of fluoride rinses, or of
stannous fluoride, acidulated phosphate fluoride, or sodium fluoride gels, and thus
no single protocol can be recommended. Accordingly, different centers have used
these products interchangeably--for example, selecting a rinse regimen if patients
complain of gagging when using a gel applied in a tray, or if the cost of the tray
is prohibitive. Recent innovations that show promise for treatment of high-caries-
risk patients with hyposalivation are the use of fluoride rinses in combination
with chlorhexidine rinses or gels and the professional application of high-
concentration chlorhexidine varnishes to the teeth.
AN - rayyan-563561065
AU - Newbrun, E.
DO - 10.1177/08959374960100010401
IS - 1
chlorhexidine
fluoride varnish
dental procedure
dental caries
human
review
Sjoegren syndrome
xerostomia
LA - English
PY - 1996
SN - 0895-9374
SP - 29-34
ST - Current treatment modalities of oral problems of patients with Sjögren's
syndrome: caries prevention
T2 - Adv. Dent. Res.
TI - Current treatment modalities of oral problems of patients with Sjögren's
syndrome: caries prevention
VL - 10
ID - 14439
ER -
TY - JOUR
AN - rayyan-563562111
AU - Newman, H. N.
DO - 10.1111/j.1600-051X.1986.tb01435.x
IS - 10
PY - 1986
SP - 965-974
ST - Modes of application of anti‐plaque chemicals
TI - Modes of application of anti‐plaque chemicals
0022927711&doi=10.1111%2fj.1600-
051X.1986.tb01435.x&partnerID=40&md5=1735c197a5f153e509a00f8890c60802
VL - 13
ID - 15485
ER -
TY - JOUR
AB - Severe periodontitis is a highly prevalent dental disease. With the advent of
implant dentistry, teeth are often extracted and replaced. Periodontal surgery,
where indicated, could also result in increased trauma to the patient. This
literature review discusses different treatment modalities for periodontitis and
proposes a treatment approach emphasizing maximum preservation of teeth while
minimizing morbidity to the patient. Scientific articles were retrieved from the
MEDLINE/PubMed database up to January 2021 to identify appropriate articles that
addressed the objectives of this review. This was supplemented with hand searching
using reference lists from relevant articles. As tooth prognostication does not
have a high predictive value, a more conservative approach in extracting teeth
should be abided by. This may involve repeated rounds of nonsurgical periodontal
therapy, and adjuncts such as locally delivered statin gels and subantimicrobial-
dose doxycycline appear to be effective. Periodontal surgery should not be carried
out at an early phase in therapy as improvements in nonsurgical therapy may be
observed up to 12 months from initial treatment. Periodontal surgery, where
indicated, should also be minimally invasive, with periodontal regeneration being
shown to be effective over 20 years of follow-up. Biomarkers provide an opportunity
for early detection of disease activity and personalised treatment. Quality of life
is proposed as an alternative end point to the traditional biomedical paradigm
focused on the disease state and clinical outcomes. In summary, minimally invasive
therapy aims to preserve health and function of the natural dentition, thus
improving the quality of life for patients with periodontitis.
AN - rayyan-563560043
AU - Ng, E.
AU - Tay, J. R. H.
AU - Ong, M. M. A.
DO - 10.1155/2021/2810264
biological marker
biomaterial
doxycycline
gel
probiotic agent
adult
antibiotic therapy
clinical outcome
disease activity
drug efficacy
follow up
human
long term care
Medline
meta analysis
minimally invasive procedure
minimally invasive surgery
morbidity
organ preservation
outcome assessment
patient compliance
periodontal disease
periodontics
periodontitis
periodontium
philosophy
predictive value
prognosis
quality of life
relapse
review
risk reduction
systematic review
tissue flap
tooth
LA - English
PY - 2021
SN - ["1687-8736", "1687-8728"]
ST - Minimally Invasive Periodontology: A Treatment Philosophy and Suggested
Approach
T2 - Int. J. Dent.
TI - Minimally Invasive Periodontology: A Treatment Philosophy and Suggested
Approach
VL - 2021
ID - 13417
ER -
TY - JOUR
AB - Gingival crevicular fluid (GCF) is a pathophysiological fluid that flows into
the oral cavity. Human GCF was collected using sterile glass microcapillary tubes
from inflamed periodontal sites in patients who had a history of periodontal
disease and were in the maintenance phase of treatment. Samples from individual
sites were analyzed using MS techniques both before and following HPLC. GCF samples
were also pooled and subjected to SDS-PAGE, in-gel digestion and MS analyses using
both MALDI-TOF/TOF MS and nanoLC-ESI-MS/MS. MS spectra were used to search human
protein sequence databases for protein identification. With these approaches, 33
peptides and 66 proteins were positively identified in human GCF. All of the
peptides discovered in this study are reported in GCF here for the first time.
Forty-three of the identified proteins, such as actin and the actin binding
proteins profilin, cofilin and gelsolin, have not been reported in GCF before.
AN - rayyan-563562546
AU - Ngo, L. H.
AU - Veith, P. D.
AU - Chen, Y. Y.
AU - Chen, D.
AU - Darby, I. B.
DO - 10.1021/pr900775s
IS - 4
PY - 2010
SN - ["1535-3893", "1535-3907"]
SP - 1683-1693
ST - Mass Spectrometric Analyses of Peptides and Proteins in Human Gingival
Crevicular Fluid
T2 - JOURNAL OF PROTEOME RESEARCH
TI - Mass Spectrometric Analyses of Peptides and Proteins in Human Gingival
Crevicular Fluid
VL - 9
Y2 - 4
ID - 15920
ER -
TY - JOUR
AB - Background: In order to prove the idea that topical application of drugs can
improve the clinical parameters affecting periodontal disease, a sound comparison
should be made between topical therapeutic models. The aim of the present study was
to assess the clinical efficacy of photodynamic therapy (PDT) and Salvadora persica
(SP) gel as adjuncts to scaling and root planning (SRP) in the treatment of chronic
periodontitis. Methods: The selected patients were divided into three groups, Group
I (PDT + SRP), Group II (SP + SRP) and group III (SRP alone). Clinical inflammatory
periodontal parameters including plaque index (PI), bleeding on probing (BOP),
probing depth (PD) and clinical attachment level (CAL) gain were assessed.
Assessment of crevicular fluid interleukin (IL)-6 and tumor necrosis factor alpha
(TNF-α) was performed using enzyme-linked immunosorbent assay technique. All
measurements were recorded at baseline, 3 months and 6 months follow-up periods,
respectively. Results: A total of 73 patients completed the study. A significant
improvement in the BOP was seen in Group II at both follow up visits when compared
with other groups (p < 0.05). Only in Group-I that showed statistically significant
reduction in moderate periodontal pockets at 3 months (p = 0.021), and significant
reductions in deep pockets at 3-months (p = 0.003) and 6-months (p = 0.002),
respectively. CAL gain also was reported to be seen in group-I at both visits (p <
0.05). Group- I and II significantly reduced the levels of IL-6 at 3-month period
compared to Group-III. This reduction was further maintained by group-II and group-
III at 6 months, respectively. TNF-α showed statistically significant decrease in
Group II as compared to Group I and Group-III and this reduction was maintained by
the end of 6-month visit (p = 0.045). Conclusion: Both the treatment modalities PDT
and SP helped in reducing periodontal inflammation. PDT reported significant gain
in clinical attachment level, whereas the SP significantly reduced the bleeding
levels.
AN - rayyan-563560133
AU - Niazi, F. H.
AU - Noushad, M.
AU - Tanvir, S. B.
AU - Ali, S.
AU - Al-Khalifa, K. S.
AU - Qamar, Z.
AU - Al-Sheikh, R.
DO - 10.1016/j.pdpdt.2020.101665
KW - indocyanine green
interleukin 6
plant extract
Salvadora persica extract
unclassified drug
adult
article
bleeding
controlled study
dental scaling
female
follow up
gel
human
male
plaque index
priority journal
Salvadora persica
topical treatment
LA - English
PY - 2020
SN - ["1873-1597", "1572-1000"]
ST - Antimicrobial efficacy of indocyanine green-mediated photodynamic therapy
compared with Salvadora persica gel application in the treatment of moderate and
deep pockets in periodontitis
TI - Antimicrobial efficacy of indocyanine green-mediated photodynamic therapy
compared with Salvadora persica gel application in the treatment of moderate and
deep pockets in periodontitis
VL - 29
ID - 13507
ER -
TY - JOUR
AN - rayyan-563560929
AU - Nicolatou-Galitis, O.
IS - 4
KW - metronidazole
miconazole
adult
article
blood cell count
case report
continuing education
disease duration
gel
gingivitis
helper cell
human
immune deficiency
lymphocyte count
male
mouth ulcer
pain
suppressor cell
LA - English
PY - 2000
SN - 1105-3992
SP - 419
ST - Oral pathology quiz (case OPQ15)
T2 - Arch. Hell. Med.
TI - Oral pathology quiz (case OPQ15)
VL - 17
ID - 14303
ER -
TY - JOUR
AB - Oral squamous cell carcinoma (OSCC), one of the most common malignant tumors
of the head and neck, is closely associated with the presence of oral microbes.
However, the microbiomes of different oral niches in OSCC patients and their
association with OSCC have not been adequately characterized. In this study, 305
samples were collected from 65 OSCC patients, including tumor tissue, adjacent
normal tissue (paracancerous tissue), cancer surface tissue, anatomically matched
contralateral normal mucosa, saliva, and tongue coat. 16S ribosomal DNA (16S rDNA)
sequencing was used to compare the microbial composition, distribution, and co-
occurrence network of different oral niches. The association between the microbiome
and the clinical features of OSCC was also characterized. The oral microbiome of
OSCC patients showed a regular ecological distribution. Tumor and paracancerous
tissues were more microbially diverse than other oral niches. Cancer surface,
contralateral normal mucosa, saliva, and tongue coat showed similar microbial
compositions, especially the contralateral normal mucosa and saliva. Periodontitis-
associated bacteria of the genera Fusobacterium, Prevotella, Porphyromonas,
Campylobacter, and Aggregatibacter, and anaerobic bacteria were enriched in tumor
samples. The microbiome was highly correlated with tumor clinicopathological
features, with several genera (Lautropia, Asteroleplasma, Parvimonas,
Peptostreptococcus, Pyramidobacter, Roseburia, and Propionibacterium) demonstrating
a relatively high diagnostic power for OSCC metastasis, potentially providing an
indicator for the development of OSCC.
AN - rayyan-563559811
AU - Nie, F.
AU - Wang, L.
AU - Huang, Y.
AU - Yang, P.
AU - Gong, P.
AU - Feng, Q.
AU - Yang, C.
DO - 10.3389/fcimb.2022.905653
laboratory device
DNA 16S
Actinobacteria
Actinomyces
adult
Aggregatibacter
article
bacterial microbiome
Bacteroidetes
Betaproteobacteria
bioinformatics
Campylobacter
controlled study
DNA extraction
DNA sequence
Escherichia coli
Eubacterium
Faecalibacterium
female
Firmicutes
Fusobacterium
gene sequence
human
human tissue
KEGG
Lactobacillus
leave one out cross validation
male
microbial community
microbial diversity
middle aged
mouth flora
nonhuman
nucleotide metabolism
Parvimonas
Parvimonas micra
Peptococcus
Peptostreptococcus
periodontitis
phylogeny
Porphyromonas
Prevotella
principal coordinate analysis
Propionibacterium
Roseburia
Rothia mucilaginosa
Stenotrophomonas maltophilia
Hiseq 2500
LA - English
PY - 2022
SN - 2235-2988
ST - Characteristics of Microbial Distribution in Different Oral Niches of Oral
Squamous Cell Carcinoma
TI - Characteristics of Microbial Distribution in Different Oral Niches of Oral
Squamous Cell Carcinoma
VL - 12
ID - 13185
ER -
TY - JOUR
AB - Antimicrobial agents, systemic and/or local, are thought by some to be
effective agents for treating periodontal infections. Here the authors determine
the costs and benefits of local delivery agents for treating periodontal disease.
Applying this cost-benefit analysis to patient care, however, will depend upon a
clinician's expertise and a patient's value system.
AN - rayyan-563560898
AU - Niederman, R.
AU - Abdelshehid, G.
AU - Goodson, J. M.
DO - 10.1016/S0011-8532(02)00030-7
IS - 4
KW - acylglycerol
antiinfective agent
cellulose
chlorhexidine
doxycycline
doxycycline hyclate
drug derivative
Elyzol Dentalgel
metronidazole
microsphere
minocycline
sesame seed oil
tetracycline
article
clinical trial
cost benefit analysis
drug approval
drug cost
economics
gel
human
meta analysis
methodology
microbiology
periodontal disease
risk assessment
treatment outcome
LA - English
PY - 2002
SN - 0011-8532
SP - 665-677, viii
ST - Periodontal therapy using local delivery of antimicrobial agents
TI - Periodontal therapy using local delivery of antimicrobial agents
VL - 46
ID - 14272
ER -
TY - JOUR
AB - Background: The etiological relationship between the plaque and the gingival
inflammation has been long established. The long-term use of chemical antiplaque
agents may lead to side effects such as teeth staining and alteration of taste.
Therefore, natural plant extracts with potential antibacterial and anti-
inflammatory activity have been explored, which are equally effective and safe for
long-term use. Objective: The aim of this study was to compare and evaluate effect
of neem gel and chlorhexidine (CHX) gel on dental plaque, gingivitis, and bacterial
count of Streptococcus mutans and Lactobacilli among 20-30-year-old school teachers
in a city of western Maharashtra, over 90 days' usage. Materials and Methods: A
double-blind, parallel armed, controlled, randomized clinical study was conducted
among 60 school teachers of 20-30 years' age group for 90 days. The two study
groups were as follows: Group A-2.5% neem gel (n = 30) and Group B-0.2% CHX gel (n
= 30). The plaque scores were recorded by Plaque Index (Löe H. The gingival index,
the plaque index and the retention index systems. J Periodontol 1967;38:610-6) and
gingival scores by Gingival Index (Löe H, Silness J. Periodontal disease in
pregnancy. Acta Odontol Scand 1963;21:533-51). Streptococcus mutans and
Lactobacilli species count by conventional culture method was carried out at
baseline, 30th day and 90thday. Considering P value 0.05 as statistically
significant, intergroup comparison was performed using unpaired t test. One-way
analysis of variance (ANOVA) test was used followed by Tukey's post hoc test for
intragroup comparison. Results: The mean plaque, gingival scores, and microbial
count of S. mutans and Lactobacilli showed significant reduction at 30th and 90th
day in neem gel group as well as CHX gel group (P 0.05). None of the parameter
showed any significant change at 30th and 90th day (P > 0.05) on intergroup
comparison. Conclusion: The neem gel showed significant decrease in dental plaque,
gingival inflammation, and microbial counts, which was comparable to CHX gel
proving to be a good herbal alternative. No side effects were reported for use of
neem gel over considered period of time.
AN - rayyan-563560110
AU - Nimbulkar, G.
AU - Garacha, V.
AU - Shetty, V.
AU - Bhor, K.
AU - Srivastava, K. C.
AU - Shrivastava, D.
AU - Sghaireen, M. G.
DO - 10.4103/jpbs.JPBS_101_20
IS - 5
KW - Azadirachta indica extract
chlorhexidine
gel
adult
article
bacterial count
clinical article
controlled study
female
gingival index
gingivitis
human
India
Lactobacillus
Maharashtra
male
periodontal disease
plaque index
post hoc analysis
pregnancy
priority journal
school teacher
tooth plaque
LA - English
PY - 2020
SN - 0975-7406
SP - S345-S351
ST - Microbiological and Clinical evaluation of Neem gel and Chlorhexidine gel on
dental plaque and gingivitis in 20-30 years old adults: A Randomized Parallel-
Armed, Double-blinded Controlled Trial
TI - Microbiological and Clinical evaluation of Neem gel and Chlorhexidine gel on
dental plaque and gingivitis in 20-30 years old adults: A Randomized Parallel-
Armed, Double-blinded Controlled Trial
VL - 12
ID - 13484
ER -
TY - JOUR
AB - Accumulating evidence indicates that TNFalpha plays an important role in the
pathogenesis of periodontitis, but the effect of TNFalpha on the degradation of the
periodontal ligament is not well understood. This study used reverse transcriptase-
PCR to investigate the effects of TNFalpha on matrix metalloproteinase (MMP) mRNA
expression in human periodontal ligament fibroblasts. TNFalpha increased MMP-1,
MMP-3 and MMP-13 mRNA levels in both a time-dependent (0-24 h) and a dose-dependent
(0.1-10 ng/ml) manner. TNFalpha also increased COX-2 mRNA levels. Because elevation
of COX-2 mRNA levels enhances the production of prostaglandins, we therefore
investigated whether endogenous prostaglandins are involved in the MMP mRNA
expression that is enhanced by TNFalpha. Pretreatment with the selective COX-2
inhibitor, NS-398, increased MMP-13 mRNA levels, while prostaglandin E2 and
dibutyryl cyclic AMP decreased MMP-13 mRNA levels. Neither MMP-1 nor MMP-3 mRNA
levels were affected by these chemicals. These findings indicate that prostaglandin
E2 has a lowering effect on TNFalpha-enhanced MMP-13 mRNA levels, and that this
effect is dependent on cAMP. Our results suggest that TNFalpha participates in
periodontal ligament destruction by stimulating the production of MMPs (MMP-1, MMP-
3 and MMP-13), while endogenous prostaglandin E2 has a negative feedback role in
TNFalpha-enhanced MMP-13 production.
AN - rayyan-563560904
AU - Nishikawa, M.
AU - Yamaguchi, Y.
AU - Yoshitake, K.
AU - Saeki, Y.
IS - 3
KW - bucladesine
cyclooxygenase 2
isoenzyme
membrane protein
messenger RNA
n (2 cyclohexyloxy 4 nitrophenyl)methanesulfonamide
nitrobenzene derivative
prostaglandin E2
prostaglandin synthase
prostaglandin synthase inhibitor
PTGS2 protein, human
sulfonamide
article
biosynthesis
cell culture
cytology
dose response
drug antagonism
drug effect
enzyme immunoassay
enzymology
fibroblast
gene expression
human
metabolism
Western blotting
LA - English
PY - 2002
SN - 0022-3484
SP - 167-176
ST - Effects of TNFalpha and prostaglandin E2 on the expression of MMPs in human
periodontal ligament fibroblasts
TI - Effects of TNFalpha and prostaglandin E2 on the expression of MMPs in human
periodontal ligament fibroblasts
VL - 37
ID - 14278
ER -
TY - JOUR
AB - The results of the effect of complex treatment on periodontal
microcirculation in patients with chronic periodontitis occurring with an iron
deficiency state. Purpose of the study: to study periodontal microcirculation in
patients with chronic periodontitis occurring against the background of iron
deficiency states. Materials and methods: As the research sources, 100 patients who
applied to the Samarkand regional dental clinic suffering from chronic
periodontitis and iron deficiency were selected. The patients were divided into 2
groups, of which 1 main group consisted of 50 patients who received glycodent gel
and an iron preparation (combined iron (II) sulfate - sorbifer durules / ascorbic
acid). The second group received the generally accepted standard therapy for
chronic periodontitis. The diagnosis of iron deficiency states was established by
determining the parameters of iron and ferritin in the blood. Microcirculation was
studied using the "Lazma" apparatus (Russia). Results and discussion: A positive
effect on microcirculation of the complex of treatment with glycodent gel and an
antianemic drug for chronic periodontitis with an iron deficiency state was
revealed.
AN - rayyan-563560099
AU - Norbutaev, A.
AU - Rizaev, J.
AU - Abduvakilov, J.
AU - Ortikova, N.
IS - 2
KW - laser
analgesic agent
ascorbic acid
ferritin
ferrous sulfate
gel
iron
adult
anemia
arthritis
article
blood flow
controlled study
female
follow up
human
iron deficiency
iron deficiency anemia
male
microcirculation
LA - English
PY - 2020
SN - 2515-8260
SP - 1680-1687
ST - Results of the effect of complex treatments on perodonot microcirculation in
child periodontitis with iron deficiency
TI - Results of the effect of complex treatments on perodonot microcirculation in
child periodontitis with iron deficiency
VL - 7
ID - 13473
ER -
TY - JOUR
AB - Gingival diseases are the most widely dispersed diseases in the United
States. In some patients, periodontal disease appears in a generalized form, but
more often it appears in localized areas. Furthermore, after treatment with scaling
and root planing in generalized cases, the disease is often reduced to a few local
areas in the patient's mouth. Because periodontitis is a bacterial infection with
known pathogenic microorganisms, the local delivery of antimicrobial agents has
been considered to be a possible solution for treating and controlling localized
forms of periodontal disease. Three local chemotherapeutic agents are reviewed in
this paper: tetracycline fiber, doxycycline gel, and chlorhexidine chip. With the
advancement of local drug delivery systems, restorative dentists, periodontists,
and their patients have new alternatives for the treatment of periodontal disease.
Local chemotherapeutic agents offer an additional mode of therapy and should be
used on a case-by-case basis, not necessarily as an initial treatment.
AN - rayyan-563560927
AU - Norkiewicz, D. S.
AU - Breault, L. G.
AU - Wonderlich, S. T.
AU - Malone, K. H.
DO - 10.1093/milmed/166.11.940
IS - 11
KW - actiste
antibiotic agent
doxycycline hyclate
chlorhexidine
doxycycline
metronidazole
minocycline
periocline
scopolamine
tetracycline
article
bacterial infection
clinical trial
gingiva disease
human
periodontal disease
periodontitis
United States
atridox
elyzol
LA - English
PY - 2001
SN - 0026-4075
SP - 940-946
ST - The use of chemotherapeutic agents in localized periodontal pockets
T2 - Mil. Med.
TI - The use of chemotherapeutic agents in localized periodontal pockets
VL - 166
ID - 14301
ER -
TY - JOUR
AB - Dental implants have 89% plus survival rates at 10-15 years, but peri-
implantitis or dental implant infections may be as high as 14%. Peri-implantitis
can limit clinical success and impose health and financial burdens to patients and
health providers. The pathogenic species associated with periodontitis (e.g.,
Fusobacterium ssp, A. actinomycetemcomitans, P. gingivalis) are also associated
with peri-implantitis. Incidence of peri-implantitis is highest within the first 12
months after implantation, and is higher in patients who smoke or have poor oral
health as well as with calcium-phosphate-coated or surface-roughened implants.
Biomaterial therapies using fibers, gels, and beads to deliver antibiotics have
been used in the treatment of Peri-implantitis though clinical efficacy is not well
documented. Guided tissue regeneration membranes (e.g., collagen,
poly-lactic/glycolic acid, chitosan, ePTFE) loaded with antimicrobials have shown
success in reosseointegrating infected implants in animal models but have not been
proven in humans. Experimental approaches include the development of anti-
bioadhesion coatings, coating surfaces with antimicrobial agents (e.g., vancomycin,
Ag, Zn) or antimicrobial releasing coatings (e.g., calcium phosphate, polylactic
acid, chitosan). Future strategies include the development of surfaces that become
antibacterial in response to infection, and improvements in the permucosal seal.
Research is still needed to identify strategies to prevent bacterial attachment and
enhance normal cell/tissue attachment to implant surfaces. © 2008 Wiley
Periodicals, Inc.
AN - rayyan-563560684
AU - Norowski Jr, P. A.
AU - Bumgardner, J. D.
DO - 10.1002/jbm.b.31152
IS - 2
biomaterial
calcium phosphate
carbenicillin
cefalotin
chitosan
chlorhexidine
collagen
doxycycline
fusidic acid
gentamicin
hydroxyapatite
metronidazole
minocycline
octenidine
polyglactin
polylactic acid
polylactide
povidone
rifampicin
silver
tetracycline
titanium dioxide
tobramycin
triclosan
unindexed drug
vancomycin
zinc
zinc oxide
antibiotic therapy
device infection
diagnostic procedure
drug efficacy
Fusobacterium
gel
high risk patient
human
incidence
coating (procedure)
mouth hygiene
nonhuman
periimplantitis
periodontitis
review
smoking
survival rate
tooth implantation
Acticite
Arestin
Atridox
LaserLok
perioChip
Politerefate
LA - English
PY - 2009
SN - ["1552-4973", "1552-4981"]
SP - 530-543
ST - Biomaterial and antibiotic strategies for peri-implantitis
TI - Biomaterial and antibiotic strategies for peri-implantitis
VL - 88
ID - 14058
ER -
TY - JOUR
AB - Dental implants have 89% plus survival rates at 10-15 years, but peri-
implantitis or dental implant infections may be as high as 14%. Peri-implantitis
can limit clinical success and impose health and financial burdens to patients and
health providers. The pathogenic species associated with periodontitis (e.g.,
Fusobacterium ssp, A. actinomycetemcomitans, P. gingivalis) are also associated
with peri-implantitis. Incidence of peri-implantitis is highest within the first 12
months after implantation, and is higher in patients who smoke or have poor oral
health as well as with calcium-phosphate-coated or surface-roughened implants.
Biomaterial therapies using fibers, gels, and beads to deliver antibiotics have
been used in the treatment of Peri-implantitis though clinical efficacy is not well
documented. Guided tissue regeneration membranes (e.g., collagen,
poly-lactic/glycolic acid, chitosan, ePTFE) loaded with antimicrobials have shown
success in reosseointegrating infected implants in animal models but have not been
proven in humans. Experimental approaches include the development of anti-
bioadhesion coatings, coating surfaces with antimicrobial agents (e.g., vancomycin,
Ag, Zn) or antimicrobial releasing coatings (e.g., calcium phosphate, polylactic
acid, chitosan). Future strategies include the development of surfaces that become
antibacterial in response to infection, and improvements in the permucosal seal.
Research is still needed to identify strategies to prevent bacterial attachment and
enhance normal cell/tissue attachment to implant surfaces. (C) 2008 Wiley
Periodicals. Inc. J Biomed Mater Res Part B: Appl Biomater 88B: 530-543, 2009
AN - rayyan-563562542
AU - Norowski, P. A.
AU - Bumgardner, J. D.
DO - 10.1002/jbm.b.31152
IS - 2
PY - 2009
SN - ["1552-4973", "1552-4981"]
SP - 530-543
ST - Biomaterial and Antibiotic Strategies for Peri-implantitis
TI - Biomaterial and Antibiotic Strategies for Peri-implantitis
VL - 88
Y2 - 2
ID - 15916
ER -
TY - JOUR
AN - rayyan-563562117
AU - Norris, J. M.
AU - Love, D. N.
DO - 10.1006/anae.1999.0261
IS - 3
PY - 1999
SP - 337-341
ST - In vivo and in vitro antimicrobial susceptibility studies of three feline
Porphyromonas species
T2 - Anaerobe
TI - In vivo and in vitro antimicrobial susceptibility studies of three feline
Porphyromonas species
0033141306&doi=10.1006%2fanae.1999.0261&partnerID=40&md5=1b71740ea7b8aadb3b628a3af4
7b118b
VL - 5
ID - 15491
ER -
TY - JOUR
AB - BACKGROUND: Previous studies showed that host modulation therapy (HMT) or
TAT in the treatment of moderate to severe CP. METHODS: A 6-month, randomized,
hyclate gel (TAT; 10%, in pockets > or =5 mm) in combination with SRP versus SRP
plus placebo. Clinical outcomes included mean changes in probing depth (PD),
clinical attachment level (CAL), bleeding on probing (BOP), and gingival index (GI)
at baseline and at 3 and 6 months. RESULTS: In 171 subjects, combination therapy
therapy provided significant benefits over control for PD (3 and 6 months: P
<0.01), CAL (3 months: P <0.01; 6 months: P <0.03), BOP (3 months: P <0.02; 6
months: P <0.05), and GI (3 months: P <0.01; 6 months: P <0.03). In severe CP (PD >
or =7 mm), combination therapy provided significant benefits over control for PD (3
and 6 months: P <0.01), CAL (3 months: P <0.01; 6 months: P <0.02), BOP (3 months:
P <0.01; 6 months: P >0.05), and GI (3 months: P <0.01; 6 months: P <0.01).
CONCLUSION: Combination therapy, including SRP, HMT, and TAT, provided
significantly greater clinical benefits than SRP alone in the treatment of moderate
to severe CP.
AN - rayyan-563561257
AU - Novak, M. J.
AU - Dawson, D. R., 3rd
AU - Magnusson, I.
AU - Karpinia, K.
AU - Polson, A.
AU - Ryan, M. E.
AU - Ciancio, S.
AU - Drisko, C. H.
AU - Kinane, D.
AU - Powala, C.
AU - Bradshaw, M.
DO - 10.1902/jop.2008.070237
IS - 1
J2 - J Periodontol
KW - Administration, Oral
Adolescent
Adult
Aged
Chronic Disease
*Dental Scaling
Doxycycline/*administration & dosage
Female
Follow-Up Studies
Humans
Male
Middle Aged
Periodontal Attachment Loss/drug therapy/therapy
Periodontal Index
Periodontitis/drug therapy/*therapy
Placebos
*Root Planing
Single-Blind Method
Treatment Outcome
LA - eng
N1 - Center for Oral Health Research, University of Kentucky, Lexington, KY 40536-
0305, USA. mjnova2@uky.edu
PY - 2008
SN - 0022-3492 (Print)
SP - 33-41
of moderate to severe periodontitis: a randomized multicenter trial
of moderate to severe periodontitis: a randomized multicenter trial
VL - 79
Y2 - 1
ID - 14631
ER -
TY - JOUR
AB - Background: Previous studies showed that host modulation therapy (HMT) or
TAT in the treatment of moderate to severe CP. Methods: A 6-month, randomized,
hyclate gel (TAT; 10%, in pockets 5 mm) in combination with SRP versus SRP plus
placebo. Clinical outcomes included mean changes in probing depth (PD), clinical
attachment level (CAL), bleeding on probing (BOP), and gingival index (GI) at
baseline and at 3 and 6 months. Results: In 171 subjects, combination therapy
therapy provided significant benefits over control for PD (3 and 6 months: P
<0.01), CAL (3 months: P <0.01; 6 months: P <0.03), BOP (3 months: P <0.02; 6
months: P <0.05), and GI (3 months: P <0.01; 6 months: P<0.03). In severe CP (PD >=
7 mm), combination therapy provided significant benefits over control for PD (3 and
6 months: P<0.01), CAL (3 months: P<0.01; 6 months: P<0.02), BOP (3 months: P<0.01;
6 months: P>0.05), and GI (3 months: P<0.01; 6 months: P<0.01). Conclusion:
Combination therapy, including SRP, HMT, and TAT, provided significantly greater
clinical benefits than SRP alone in the treatment of moderate to severe CP.
AN - rayyan-563562324
AU - Novak, M. J.
AU - Dawson, D. R.
AU - Maonusson, I.
AU - Karpinia, K.
AU - Polson, A.
AU - Ryan, M. E.
AU - Ciancio, S.
AU - Drisko, C. N. H.
AU - Kinane, D.
AU - Powala, C.
AU - Bradshaw, M.
DO - 10.1902/jop.2008.070237
IS - 1
PY - 2008
SN - ["0022-3492", "1943-3670"]
SP - 33-41
VL - 79
Y2 - 1
ID - 15698
ER -
TY - JOUR
AB - The present study describes results on selected clinical and microbiological
parameters obtained by treatment with local (Elyzol) and systemic (Flagyl) use of
metronidazole alone and/or mechanical subgingival debridement in adult
periodontitis. Patients were randomly divided into local and systemic treatment
groups each comprising 5 individuals in each of whom 4 sites (one site/ quadrant)
with a probing depth of > or = 5 mm were selected and treated with separate
treatment modalities. The overall treatment design provided 6 different test
groups. Groups of quadrants received: (1) scaling and root planing; (2) local
metronidazole treatment; (3) systemic metronidazole treatment; (4) local
metronidazole combined with scaling and root planing; (5) systemic metronidazole
combined with scaling and root planing; (6) no treatment. The microbiological and
clinical effects of treatment modalities were monitored over a period of 42 days.
All treatments resulted in clinical improvements (gingivitis, probing pocket depth,
attachment level) except for the untreated group. Parallel to the clinical changes,
all treatments reduced the number of total bacteria and proportions of obligately
anaerobic microorganisms. Although both of the combined treatment groups responded
to therapy with better resolution of infection that the pure mechanical and pure
metronidazole treatments, local metronidazole in combination with scaling and root
planing seems to be more effective in terms of producing both clinical and
microbial improvements.
AN - rayyan-563561048
AU - Noyan, U.
AU - Yilmaz, S.
AU - Kuru, B.
AU - Kadir, T.
AU - Acar, O.
AU - Büget, E.
IS - 3
KW - acylglycerol
drug derivative
Elyzol Dentalgel
metronidazole
sesame seed oil
adult
article
bacterial count
clinical trial
controlled study
drug effect
female
follow up
Fusobacterium
gel
gingivitis
human
male
microbiology
middle aged
periodontal disease
periodontitis
LA - English
PY - 1997
SN - 0303-6979
SP - 158-165
ST - A clinical and microbiological evaluation of systemic and local metronidazole
delivery in adult periodontitis patients
TI - A clinical and microbiological evaluation of systemic and local metronidazole
delivery in adult periodontitis patients
VL - 24
ID - 14422
ER -
TY - JOUR
AB - Treponema denticola is considered an important oral pathogen in the
development and progression of periodontal diseases. In the present study, the
mechanisms of recognition and activation of murine macrophages by T. denticola and
its major outer sheath protein (MSP) and lipooligosaccharide (LOS or glycolipid)
were investigated. T. denticola cells and the MSP induced innate immune responses
through TLR2-MyD88, whereas LOS induced a macrophage response through TLR4-MyD88.
The presence of gamma interferon (IFN-γ), or of high numbers of T. denticola,
circumvented the requirement for TLR2 for the macrophage response to T. denticola,
although the response was still dependent on MyD88. In contrast, synergy with IFN-γ
did not alter the TLR dependence of the response to the T. denticola surface
components LOS and MSP, despite enhanced sensitivity. These data suggest that
although there is flexibility in the requirements for recognition of T. denticola
cells (TLR2 dependent or independent), MyD88 is a requirement for the downstream
signaling events that lead to inflammation. We also demonstrate that both outer
sheath molecules LOS and MSP induce macrophage tolerance to further stimulation
with enterobacterial lipopolysaccharide. Tolerance induced by T. denticola
components during mixed infections may represent a general mechanism through which
bacteria evade clearance. Copyright © 2009, American Society for Microbiology. All
Rights Reserved.
AN - rayyan-563560667
AU - Nussbaum, G.
AU - Ben-Adi, S.
AU - Genzler, T.
AU - Sela, M.
AU - Rosen, G.
DO - 10.1128/IAI.00488-09
IS - 9
KW - gamma interferon
lipooligosaccharide
lipopolysaccharide
membrane protein
membrane protein msp
unclassified drug
animal cell
antigen recognition
article
bacterial cell
controlled study
immunoblotting
immunological tolerance
innate immunity
macrophage
mouse
nonhuman
priority journal
protein analysis
protein gel blot analysis
protein interaction
Treponema denticola
LA - English
PY - 2009
SN - ["0019-9567", "1098-5522"]
SP - 3939-3947
ST - Involvement of toll-like receptors 2 and 4 in the innate immune response to
Treponema denticola and its outer sheath components
T2 - Infect. Immun.
TI - Involvement of toll-like receptors 2 and 4 in the innate immune response to
Treponema denticola and its outer sheath components
VL - 77
ID - 14041
ER -
TY - JOUR
AB - This study aimed to develop thermosensitive in-situ microgels loaded with the
antimicrobial agent metronidazole (MTN) and the nonsteroidal anti-inflammatory drug
ibuprofen (IBU) as adjunctive therapy for periodontitis. The MTN-IBU microgels were
prepared by combining IBU-Microemulsions with MTN solution prepared with Pluronic®
F127 (F127) hydrogel. The effect of various cosolvents and Pluronic F68 (F68) on
the thermo-rheological properties (sol-gel transition temperature (Tsol→gel),
viscosity, and viscoelastic properties) of MTN-IBU microgels was studied. The
physicochemical properties of microgels were characterized by Fourier transform
infrared (FTIR) and differential scanning calorimetry (DSC). The in vitro release
and stability studies of microgels were investigated. An HPLC method was developed
for the simultaneous quantification of MTN and IBU. Results showed that microgels
were thermosensitive exhibiting Tsol→gel of 25–37 °C, pseudoplastic flow, and
viscoelastic properties. The thermo-rheological properties of microgels were
dependent on the concentration of F127, IBU-Microemulsion, cosolvents, and F68.
Stability studies demonstrated that the thermo-rheological properties of microgels
decreased after six months, except microgels containing F68 that were able to
maintain their strength and undergo the phase transition. Microgels provided a
complete MTN release after 8 h and a sustained IBU release for 24–48 h. This study
highlighted the significance of in-situ microgels for delivering a combined therapy
of MTN and IBU using two drug delivery systems (IBU-microemulsion and F127 sol) and
the ability to modulate the thermo-rheological properties of microgels via the
addition of various cosolvents and F68 to F127-based microgels as potential
platforms for periodontitis.
AN - rayyan-563559860
AU - Obaidat, R.
AU - Abu Kwiak, A. D.
AU - Hamed, R.
DO - 10.1016/j.jddst.2022.103314
KW - hydrogel
ibuprofen
metronidazole
microgel (material)
poloxamer
water oil cream
article
drug release
drug solubility
drug stability
flow kinetics
heat sensitivity
in vitro study
mathematical model
microemulsion
periodontitis
phase transition
physical chemistry
shear flow
shear rate
sol-gel
strength
synthesis
viscoelasticity
viscosity
viscous modulus
Young modulus
LA - English
PY - 2022
SN - 1773-2247
ST - Development of combined therapy of metronidazole and ibuprofen using in situ
microgels for the treatment of periodontitis
TI - Development of combined therapy of metronidazole and ibuprofen using in situ
microgels for the treatment of periodontitis
VL - 71
ID - 13234
ER -
TY - JOUR
AB - Transforming growth factor-β (TGF-β) increases steady-state mRNA levels of
several extracellular matrix proteins in mineralized connective tissues. Bone
sialoprotein (BSP) is a major constituent of the bone matrix, thought to initiate
and regulate the formation of mineral crystals. To determine the molecular pathways
of TGF-β1 regulation of bone proteins, we have analyzed the effects of the TGF-β on
the expression of the BSP in the rat osteosarcoma cell line (ROS 17/2.8). TGF-β1 at
1 ng/ml, increased BSP mRNA levels in ROS 17/2.8 cells ~8-fold; the stimulation was
first evident at 3 hr, reached maximal levels at 12 hr and slowly declined
thereafter. Since the stability of the BSP mRNA was not significantly affected by
TGF- β1, and nuclear 'run-on' transcription analyses revealed only a ~2-fold
increase in the transcription of the BSP gene, most of the increase in BSP mRNA
appeared to involve a nuclear post-transcriptional mechanism. Moreover, the effects
of TGF-β1 were indirect, since the increase in BSP mRNA was abrogated by
cycloheximide (28 μg/ml). To identify the site of transcriptional regulation by
TGF-β1, transient transfection analyses were performed using BSP gene promoter
constructs linked to a luciferase reporter gene. Constructs that included nt -801
to -426 of the promoter sequence were found to enhance transcriptional activity
~1.8-fold in cells treated with TGF-β1. Within this sequence, ~500 nt upstream of
the transcription start site, a putative TGF-β activation element (TAE) was
identified that contained the 5'-portion of the nuclearfactor-1 (NF-1) canonical
sequence (TTGGC) overlapping a consensus sequence for activator protein-2 (AP-2).
The functionality of the TAE was shown by an increased binding of a nuclear protein
from TGF-β1 stimulated cells in gel mobility shift assays and from the attenuation
of TGF-β1 induced luciferase activity when cells were co- transfected with a double
stranded TAE oligonucleotide. Competition gel mobility shift analyses revealed that
the nuclear protein that binds to the TAE has similar properties to, but is
distinct from, NF-1 nuclear protein. These studies have therefore identified a TGF-
β activation element (TAE) in the rat BSP gene promoter that mediates the
stimulatory effects of TGF-β1 on BSP gene transcription.
AN - rayyan-563561042
AU - Ogata, Y.
AU - Niisato, N.
AU - Furuyama, S.
AU - Cheifetz, S.
AU - Kim, R. H.
AU - Sugiya, H.
AU - Sodek, J.
DO - 10.1002/(SICI)1097-4644(19970615)65:4<501::AID-JCB6>3.0.CO;2-S
IS - 4
KW - cycloheximide
luciferase
nuclear factor I
nuclear protein
sialoprotein
animal cell
animal tissue
article
bone development
bone matrix
controlled study
gene activation
immunoregulation
nonhuman
priority journal
promoter region
protein binding
rat
LA - English
PY - 1997
SN - 0730-2312
SP - 501-512
ST - Transforming growth factor-β1 regulation of bone sialoprotein gene
transcription: Identification of a TGF-β activation element in the rat BSP gene
promoter
T2 - J. CELL. BIOCHEM.
TI - Transforming growth factor-β1 regulation of bone sialoprotein gene
transcription: Identification of a TGF-β activation element in the rat BSP gene
promoter
VL - 65
ID - 14416
ER -
TY - JOUR
AB - We found that the culture supernatant of the periodontopathic bacterium
Actinobacillus actinomycetemcomitans had a cytotoxic effect on several cell lines.
In this study, we purified the toxin from the culture supernatant of A.
actinomycetemcomitans Y4 by a four-step procedure: ammonium sulfate precipitation,
POROS HQ/M column chromatography, polymyxin B matrix column chromatography, and
Mono-Q column chromatography. The purified toxin gave two major bands of protein
with molecular masses of 80 and 85 kDa upon sodium dodecyl sulfate-polyacrylamide
gel electrophoresis. The mechanism of cell death of the B-cell hybridoma cell line
HS-72 was examined by observing changes in nuclear morphology, an increase in the
proportion of fragmented DNA, and the typical ladder pattern of degraded
chromosomal DNA, indicating the induction of apoptosis. Overexpression of human
Bcl-2 suppressed apoptosis in HS-72 cells, indicating that the toxin from A.
actinomycetemcomitans induces apoptosis by a Bcl-2-inhibitable mechanism. Flow
cytometric analysis revealed that the toxin caused cell cycle arrest in the G2/M
phase and apoptosis in HS-72 cells. In addition, aurintricarboxylic acid, a DNA
endonuclease inhibitor, markedly decreased the percentage of apoptotic cells but
had no effect on cell cycle arrest in the G2/M phase. Taken together, these
findings suggest that the toxin from A. actinomycetemcomitans could mediate the
development of periodontal diseases through cell cycle arrest in the G2/M phase and
apoptosis in B lymphocytes of periodontal tissue.
AN - rayyan-563561034
AU - Ohguchi, M.
AU - Ishisaki, A.
AU - Okahashi, N.
AU - Koide, M.
AU - Koseki, T.
AU - Yamato, K.
AU - Noguchi, T.
AU - Nishihara, T.
DO - 10.1128/iai.66.12.5980-5987.1998
IS - 12
KW - ammonium sulfate
bacterial toxin
DNA fragment
polymyxin B
animal cell
apoptosis
article
B lymphocyte
cell cycle G2 phase
cell cycle phase
cytotoxicity
DNA degradation
flow cytometry
molecular weight
mouse
nonhuman
periodontal disease
priority journal
LA - English
PY - 1998
SN - 0019-9567
SP - 5980-5987
ST - Actinobacillus actinomycetemcomitans toxin induces both cell cycle arrest in
the G2/M phase and apoptosis
T2 - Infect. Immun.
TI - Actinobacillus actinomycetemcomitans toxin induces both cell cycle arrest in
the G2/M phase and apoptosis
VL - 66
ID - 14408
ER -
TY - JOUR
AB - We have developed a new assay method for collagenase activity, in the
presence of two different types of collagenase inhibitors, in culture medium of
periodontal ligament (PDL) cells. Human PDL cells were cultured with serum-free
alpha-MEM for 5 days after reaching confluency, and the culture medium was then
harvested. Collagenase and collagenase inhibitors in the medium were concentrated
by ammonium sulfate precipitation. The precipitate was dissolved, and the
suspension was applied to an Ultrogel AcA 54 column for partial purification.
Collagenase inhibitor activity was detected as two peaks; a small inhibitor
molecule of about 32 kDa sensitive only to dithiothreitol (DTT), and a large one of
about 70 kDa considerably more sensitive to 4-aminophenylmercuric acetate (APMA)
than to DTT. Therefore, pretreatment of the sample preparation with both DTT and
APMA was necessary in order to inactivate the inhibitors prior to assay of latent
collagenase. This observation indicates that PDL cells secrete collagenase and two
collagenase inhibitors without any stimulation in vitro.
AN - rayyan-563561140
AU - Ohshima, M.
AU - Kuwata, F.
AU - Sasai, Y.
AU - Otsuka, K.
AU - Suzuki, K.
DO - 10.2334/josnusd1959.35.109
IS - 2
KW - collagenase
dithiothreitol
glycoprotein
metalloproteinase
article
cell culture
drug antagonism
enzyme activation
enzymology
human
metabolism
secretion (process)
LA - English
PY - 1993
SN - 0029-0432
SP - 109-117
ST - Collagenase and collagenase inhibitors secreted by cultured human periodontal
ligament cells
T2 - J Nihon Univ Sch Dent
TI - Collagenase and collagenase inhibitors secreted by cultured human periodontal
ligament cells
VL - 35
ID - 14514
ER -
TY - JOUR
AB - Burst release of carbamide peroxide (CP) from traditional hydrogels causes
severe inflammation to periodontal tissues. The present study explores the
development of a novel CP nanoemulgel (CP-NG), an oil-in-water nanoemulsion-based
gel in which CP was loaded with a view to controlling CP release. CP solid
dispersions were prepared, using white soft paraffin or polyvinylpyrrolidone-white
soft paraffin mixture as a carrier, prior to formulating nanoemulsions. It was
found that carrier type and the ratio of CP to carrier affected drug crystallinity.
Nanoemulsions formulated from the optimized CP solid dispersions were used to
prepare CP-NG. It was found that the ratio of drug to carrier in CP solid
dispersions affected the particle size and zeta potential of the nanoemulsions as
well as drug release behavior and tooth bleaching efficacy of CP-NG. Drug release
from CP-NG followed a first-order kinetic reaction and the release mechanism was an
anomalous transport. Drug release rate decreased with an increase in solid
dispersion carriers. CP-NG obtained from the solid dispersion with a 1:1 ratio of
CP to the polymer mixture is suitable for sustaining drug release with high tooth
bleaching efficacy and without reduction of enamel microhardness. The developed CP-
NG is a promising potential tooth bleaching formulation.
AN - rayyan-563560022
AU - Okonogi, S.
AU - Kaewpinta, A.
AU - Khongkhunthian, S.
AU - Chaijareenont, P.
DO - 10.3390/ph14020132
IS - 2
KW - carbamide peroxide
nanoemulgel
nanogel
oil
paraffin
povidone
unclassified drug
water
article
controlled study
crystal
dental procedure
dispersion
drug formulation
enamel
ex vivo study
human
in vitro study
nanoemulsion
particle size
solid
zeta potential
LA - English
PY - 2021
SN - 1424-8247
SP - 1-21
ST - Development of controlled-release carbamide peroxide loaded nanoemulgel for
tooth bleaching: In vitro and ex vivo studies
TI - Development of controlled-release carbamide peroxide loaded nanoemulgel for
tooth bleaching: In vitro and ex vivo studies
VL - 14
ID - 13396
ER -
TY - JOUR
AB - The current research study is based on the design and development of a sol-
gel biodegradable controlled-release formulation for use in the treatment of
periodontal diseases. Glycerylmonooleate (GMO) was used as a main composition in
the gel base. The influence of various additives, e.g., glycerylmonostearate (GMS),
methylcellulose (MC), surfactants, and triglycerides, in GMO formulations on
rheologic and swelling properties and release characteristics was described. It was
demonstrated that the surfactants and triglycerides affected rheologic behavior,
whereas GMS and MC influenced both rheologic and swelling properties of the bases.
The release study revealed that drug released from the gel bases depended on the
square root of time. The kinetics can be explained by the Higuchi's diffusion
theory. Some polyols could enhance drug release from the gel. The stability results
suggested that the dental gels obtained should be kept in the low temperature
range.
AN - rayyan-563560859
AU - Okonogi, S.
AU - Khongkhunthain, S.
AU - Bunyaratavej, P.
AU - Thusaphorn, T.
AU - Umpriwan, R.
DO - 10.1081/DDC-120030929
IS - 4
KW - glycerol oleate
glycerol stearate
methylcellulose
polyol
surfactant
tetracycline
triacylglycerol
antibiotic therapy
article
bacterial flora
biodegradation
drug formulation
drug release
drug stability
flow kinetics
gel
periodontal disease
tooth implantation
LA - English
PY - 2004
SN - 0363-9045
SP - 347-357
ST - Development of local injectable dental gel: The influence of certain
additives on physicochemical properties of glycerylmonooleate-based formulations
TI - Development of local injectable dental gel: The influence of certain
additives on physicochemical properties of glycerylmonooleate-based formulations
VL - 30
ID - 14233
ER -
TY - JOUR
AB - Twenty-three patients with generalized periodontitis were examined.
Microbiologic examination of the periodontal pouch contents, making use of
anaerobic cultivation, resulted in isolation and identification of 103 strains, 76
(72.8%) of which were referred to obligate anaerobes. Facultative anaerobes made up
27.2% of the total number of the isolates. Therapy with water-soluble nitasole
resulted in reduction of the number of microorganisms, decrease or arrest of pus
discharge from the pouch, resolution of the edema and gingival ridge hyperemia,
etc. Diffusion of nitasole (water-soluble) and cliostom from various dressings used
in periodontitis was studied and the efficacy of combining these dressings
revealed.
AN - rayyan-563561157
AU - Oleinik, I. I.
AU - Maksimovskii, I. M.
AU - Ushakova, T. V.
AU - Tsarev, V. N.
AU - Chekhova, N. O.
AU - Rudneva, E. V.
IS - 6
KW - aminitrozole
antiinfective agent
thiazole derivative
adult
article
comparative study
drug screening
gel
human
microbiology
middle aged
periodontic device
periodontitis
solubility
LA - Russian
PY - 1991
SN - 0039-1735
SP - 8-10
ST - The effect of nitazole preparations on the microflora in periodontitis
T2 - Vliianie preparatov nitazola na mikrofloru pri parodontite.
TI - The effect of nitazole preparations on the microflora in periodontitis
ID - 14531
ER -
TY - JOUR
AB - Background: Periodontal disease affects a large proportion of dogs, causing
both local and systemic symptoms. Several studies to identify alternative
approaches for plaque reduction and removal have been conducted. Recently,
Tropiclean Fresh Breath Clean Teeth Gel was introduced as an adjuvant to aid in
plaque and calculus removal. This product is formulated using Aloe vera, green tea,
and mint; however, studies on the toxic potential of this product have not been
performed yet. The aim of this study was to evaluate the influence of Tropiclean
Fresh Breath Clean Teeth Gel product on hematological and biochemical profiles in
dogs undergoing 90-day treatment with the product. Materials, Methods & Results:
Per manufacturers’ recommendation, the product should be used daily for 30
consecutive days, and subsequently, as maintenance at two to three times a week. In
this study, 48 dogs with periodontal disease who received prolonged daily treatment
for 90 consecutive days underwent hematological and biochemical evaluation. During
the 90 days’ treatment duration, the animals were examined daily to identify the
presence of adverse effects; and changes in halitosis were reported. At pre-
treatment time-point, 5 mL of blood was collected via cephalic or jugular vein
puncture in EDTA tubes for determining the complete blood count (CBC), and in tubes
without EDTA for the urea, creatinine, and ALT levels; in addition, for comparison,
blood was collected after 90 days’ treatment. At post-treatment time-point, the
hematological and biochemical analyses showed significantly lower total leukocyte
count as compared to that at pretreatment (P < 0.01); comprising lower neutrophil
count as the cell type involved (P < 0.05). The other parameters showed no
statistically significant differences, demonstrating an absence of the products’
effect in terms of alteration of these profiles. All the dogs showed absence of
apathy, vomiting, diarrhea, reduced appetite, or abnormalities in the mucosal
color; in addition, all showed improvement in halitosis; of which, 39 showed
improvement at 1 weeks’ treatment duration. Discussion: In the present study, the
analyzed parameters were used to determine the hemolysis, leukocytes or platelet
abnormalities, renal function, and liver injury. The kidneys and liver are organs
that are closely linked to the metabolism and excretion of drugs; hence, their
functions are often altered by the toxic effects of some substances. Despite the
reported toxicity of Aloe vera, in the present study, there were no changes in the
hematological and biochemical parameters in the dogs undergoing treatment for 90
days, except for the reduced total leukocyte count with differential reduction of
the neutrophil population, indicating the products’ safety at 90-days’ treatment
duration. The hematological and biochemical results were corroborated by the result
of the absence of abnormal clinical signs at daily evaluation. In the dogs included
in this study, the reduction of halitosis was associated with the reduction of the
leukocyte count related to the bactericidal and bacteriostatic properties of the
active ingredients of Aloe vera such as opirocatechol, cinnamic acid, ascorbic
acid, and p-coumaric acid which were reported in the field of dentistry; and with
regard to green tea, catechin galatoepigallocatechin (EgCG) may be responsible for
the bactericidal and bacteriostatic effects. Thus, the product at 90 days’
treatment duration showed safety, without changes in the hematological and
biochemical profiles in the participating dogs.
AN - rayyan-563560226
AU - Oliveira Andrade, L. P.
AU - Gualberto Oliveira, N. G. S.
AU - Magalhães, F. A.
AU - Munhoz, A. D.
AU - Wenceslau, A. A.
AU - Alberto Carlos, R. S.
DO - 10.22456/1679-9216.94861
IS - 1
KW - ABC Vet
autoanalyzer
BIO-2000 IL
blood cell counter
ascorbic acid
catechin galatoepigallocatechin
cinnamic acid
coumaric acid
creatinine
gel
opirocatechol
unclassified drug
urea
Aloe vera
article
blood cell count
clinical feature
dog
gingivitis
halitosis
hematocrit
hematological parameters
hemolysis
leukocyte count
neutrophil count
nonhuman
periodontal disease
tea
tooth calculus
tooth plaque
LA - English
PY - 2019
SN - ["1679-9216", "1678-0345"]
ST - Hematological and biochemical evaluation of dogs undergoing treatment with
veterinary dental gel for the reduction of plaque and dental calculus
T2 - Acta Sci. Vet.
TI - Hematological and biochemical evaluation of dogs undergoing treatment with
veterinary dental gel for the reduction of plaque and dental calculus
VL - 47
ID - 13600
ER -
TY - JOUR
AB - Dental caries are among pathologies that attack more frequently the oral
cavity and it is considered a public health's problem. The aim of the present work
was to analyze the essential oils obtained from Cymbopogon citratus, Eugenia
caryophyllata and Cinnamomum zeylanicum, to be incorporated in formulation of tooth
gel as well as to evaluate their antimicrobial activity against cariogenic
microorganisms Streptococcus mutans and Lactobacillus casei using agar diffusion
methods. The results showed that the essential oils and tooth gel formulation
caused inhibition on bacterial growth and so they could be used in the periodontal
diseases and dental plaque prevention.
AN - rayyan-563560720
AU - Oliveira, S. M. M.
AU - Lorscheider, J. A.
AU - Nogueira, M. A.
IS - 2
KW - cinnamomum zeylanicum extract
Cymbopogon citratus extract
essential oil
Eugenia caryophyllata extract
plant extract
agar diffusion
article
dental procedure
drug formulation
gel
in vitro study
Lactobacillus casei
LA - Portuguese
PY - 2008
SN - 0326-2383
SP - 266-269
ST - In vitro evaluation of a tooth gel containing esential oils on cariogenic
bacterias
T2 - Avaliação da ação in vitro de gel dentifrício contendo óleos essenciais sobre
bactérias cariogênicas
TI - In vitro evaluation of a tooth gel containing esential oils on cariogenic
bacterias
VL - 27
ID - 14094
ER -
TY - JOUR
AB - The rapid rise in the health burden associated with chronic wounds is of
great concern to policymakers, academia, and industry. This could be attributed to
the devastating implications of this condition, and specifically, chronic wounds
which have been linked to invasive microbial infections affecting patients’ quality
of life. Unfortunately, antibiotics are not always helpful due to their poor
penetration of bacterial biofilms and the emergence of antimicrobial resistance.
Hence, there is an urgent need to explore antibiotics-free compounds/formulations
with proven or potential antimicrobial, anti-inflammatory, antioxidant, and wound
healing efficacy. The mechanism of antibiotics-free compounds is thought to include
the disruption of the bacteria cell structure, preventing cell division, membrane
porins, motility, and the formation of a biofilm. Furthermore, some of these
compounds foster tissue regeneration by modulating growth factor expression. In
this review article, the focus is placed on a number of non-antibiotic compounds
possessing some of the aforementioned pharmacological and physiological activities.
Specific interest is given to Aloe vera, curcumin, cinnamaldehyde, polyhexanide,
retinoids, ascorbate, tocochromanols, and chitosan. These compounds (when alone or
in formulation with other biologically active molecules) could be a dependable
alternative in the management or prevention of chronic wounds.
AN - rayyan-563559856
AU - Oluwole, D. O.
AU - Coleman, L.
AU - Buchanan, W.
AU - Chen, T.
AU - La Ragione, R. M.
AU - Liu, L. X.
IS - 5
KW - hydrogel dressing
adapalene
alkanol
ascorbic acid
bexarotene
biocide
chitosan
chloramphenicol
chlortetracycline
cinnamaldehyde
cisplatin
collagen
curcumin
doxycycline
elastin
folic acid
gelling agent
growth factor
hydrogel
isotretinoin
linezolid
liposome
nitric oxide
procollagen
resveratrol
retinoid
tazarotene
terpene
acne vulgaris
Aloe vera
apoptosis
Aspergillus niger
Bacillus subtilis
bacterial growth
bacterial load
biocompatibility
biodegradability
biofilm
biological activity
cell division
cell migration
cell proliferation
cholestasis
chronic wound
contact dermatitis
cytotoxicity
debridement
DNA damage
DNA replication
dry skin
electrospinning
enzyme activity
erythema
Escherichia coli
fever
folate metabolism
gene expression
gingivitis
granulation tissue
lipid peroxidation
prevalence
protein expression
Proteus mirabilis
psoriasis
quality of life
radiation exposure
review
RNA metabolism
scurvy
Serratia marcescens
skin irritation
upregulation
wound healing
LA - English
PY - 2022
SN - 1999-4923
ST - Antibiotics-Free Compounds for Chronic Wound Healing
T2 - Pharmaceutics
TI - Antibiotics-Free Compounds for Chronic Wound Healing
VL - 14
ID - 13230
ER -
TY - JOUR
AB - Curcumin, a potent active compound found in turmeric and Curcuma xanthorrhiza
oil, possesses a wide range of therapeutic properties, including antibacterial,
anti-inflammatory, antioxidant, and wound healing activities. However, its clinical
effectiveness is hindered by its low bioavailability and rapid elimination from the
body. To overcome these limitations, researchers have explored innovative delivery
systems for curcumin. Some promising approaches include solid lipid nanoparticles,
nanomicelle gels, and transdermal formulations for topical drug delivery. In the
field of dentistry, curcumin gels have shown effectiveness against oral disorders
and periodontal diseases. Moreover, Pickering emulsions and floating in situ
gelling systems have been developed to target gastrointestinal health. Furthermore,
curcumin-based systems have demonstrated potential in wound healing and ocular
medicine. In addition to its therapeutic applications, curcumin also finds use as a
food dye, contraception aid, corrosion-resistant coating, and environmentally
friendly stain. This paper primarily focuses on the development of gel compositions
of curcumin to address the challenges associated with its clinical use.
AN - rayyan-563560962
AU - Omidian, H.
AU - Wilson, R. L.
AU - Chowdhury, S. D.
DO - 10.3390/gels9080596
IS - 8
J2 - Gels
LA - eng
N1 - Barry and Judy Silverman College of Pharmacy, Nova Southeastern University,
Fort Lauderdale, FL 33328, USA.; Barry and Judy Silverman College of Pharmacy, Nova
Southeastern University, Fort Lauderdale, FL 33328, USA.; Barry and Judy Silverman
College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
PY - 2023
ST - Enhancing Therapeutic Efficacy of Curcumin: Advances in Delivery Systems and
Clinical Applications
TI - Enhancing Therapeutic Efficacy of Curcumin: Advances in Delivery Systems and
Clinical Applications
VL - 9
Y2 - 7 y3 - 25
ID - 14336
ER -
TY - JOUR
AN - rayyan-563561162
AU - Oosterwaal, P. J. M.
AU - Mikx, F. H. M.
AU - Van 't Hof, M. A.
AU - Renggli, H. H.
IS - 4
KW - chlorhexidine
elmex
fluoride
stannous fluoride
adult
article
bacterial count
clinical article
controlled study
female
human
male
periodontitis
tooth flora
LA - English
PY - 1991
SN - 0303-6979
SP - 245-251
ST - Comparison of the antimicrobial effect of the application of chlorhexidine
gel, amine fluoride gel and stannous fluoride gel in debrided periodontal pockets
TI - Comparison of the antimicrobial effect of the application of chlorhexidine
VL - 18
ID - 14536
ER -
TY - JOUR
AN - rayyan-563561164
AU - Mikx, F. H. M.
AU - Van 't Hof, M. A.
AU - Renggli, H. H.
DO - 10.1111/j.1600-051X.1991.tb01696.x
IS - 2
KW - chlorhexidine
elmex
fluoride
placebo
stannous fluoride
adult
article
Bacteroides
clinical article
female
gel
human
male
nonhuman
tooth plaque
LA - English
PY - 1991
SN - 0303-6979
SP - 97-100
ST - Short-term bactericidal activity of chlorhexidine gel, stannous fluoride gel
and amine fluoride gel tested in periodontal pockets
TI - Short-term bactericidal activity of chlorhexidine gel, stannous fluoride gel
VL - 18
ID - 14538
ER -
TY - JOUR
AN - rayyan-563561176
AU - Mikx, F. H. M.
AU - Van Den Brink, M. E.
AU - Renggli, H. H.
DO - 10.1111/j.1600-0765.1989.tb00871.x
IS - 2
KW - amoxicillin
elmex
metronidazole
stannous fluoride
article
Capnocytophaga sputigena
cell culture
drug efficacy
drug sensitivity
Porphyromonas
serum
flemoxin
floran
LA - English
PY - 1989
SN - 0022-3484
SP - 155-160
ST - Bactericidal concentrations of chlorhexidine-digluconate, amine fluoride gel
and stannous fluoride gel for subgingival bacteria tested in serum at short contact
times
TI - Bactericidal concentrations of chlorhexidine-digluconate, amine fluoride gel
times
VL - 24
ID - 14550
ER -
TY - JOUR
AN - rayyan-563562138
AU - Mikx, F. H. M.
AU - van't Hof, M. A.
AU - Renggli, H. H.
DO - 10.1111/j.1600-051X.1991.tb00422.x
IS - 4
PY - 1991
SP - 245-251
0026093476&doi=10.1111%2fj.1600-
051X.1991.tb00422.x&partnerID=40&md5=9d9c224b152b09e23d85c9eac5db4ad9
VL - 18
ID - 15512
ER -
TY - JOUR
AN - rayyan-563562112
AU - Mikx, F. H. M.
AU - van't Hof, M. A.
AU - Renggli, H. H.
DO - 10.1111/j.1600-051X.1991.tb01696.x
IS - 2
PY - 1991
SP - 97-100
ST - Short‐term bactericidal activity of chlorhexidine gel, stannous fluoride gel
TI - Short‐term bactericidal activity of chlorhexidine gel, stannous fluoride gel
0026030595&doi=10.1111%2fj.1600-
051X.1991.tb01696.x&partnerID=40&md5=2ee246bed5d9b0b4ee485abc2e6f9d8f
VL - 18
ID - 15486
ER -
TY - JOUR
AB - The clinical and microbiological effect of locally-applied chlorhexidine gel
2%, amine fluoride gel 1.25%, stannous fluoride gel 4% or placebo gel in 40
periodontal pockets of 10 patients were studied. The gels were applied 3 x within
10 min. after mechanical debridement of the pockets. The treatment effect on the
subgingival microflora was evaluated by microscopic and culture studies of the
subgingival plaque samples. In addition, supragingival plaque, bleeding after
probing and probing pocket depth were scored. Examination were carried out before
and during a period of 36 weeks after treatment. At the start, the cultured
microflora consisted mainly of anaerobic Gram-positive bacteria. Following
treatment, the clinical parameters were significantly reduced. Concomitantly, the
%s of spirochetes, motile rods and non-motile rods decreased significantly. A
significant decrease was also found in the total anaerobic count, whereas the
facultative counts remained at the same level found before treatment. This
suggested that the treatment resulted in a mainly facultative subgingival
microflora. The % Gram-negative rods showed a significant reduction after
treatment, but returned to base line at week 12. Statistical analysis of the
bacteriological and clinical examinations failed to demonstrate any significant
differences between the 4 treatment groups. Thus, in comparison to the placebo gel,
subgingival application of chlorhexidine gel 2%, amine fluoride gel 1.25% or
stannous fluoride gel 4% did not augment the effect of mechanical debridement on
bacteriological and clinical parameters during the experimental period of 36 weeks.
However the indicated treatments resulted in a facultative subgingival microflora
which is compatible with the host.
AN - rayyan-563562175
AU - Mikx, F. H. M.
AU - Vanthof, M. A.
AU - Renggli, H. H.
DO - 10.1111/j.1600-051X.1991.tb00422.x
IS - 4
PY - 1991
SN - ["0303-6979", "1600-051X"]
SP - 245-251
ST - COMPARISON OF THE ANTIMICROBIAL EFFECT OF THE APPLICATION OF CHLORHEXIDINE
GEL, AMINE FLUORIDE GEL AND STANNOUS FLUORIDE GEL IN DEBRIDED PERIODONTAL POCKETS
TI - COMPARISON OF THE ANTIMICROBIAL EFFECT OF THE APPLICATION OF CHLORHEXIDINE
GEL, AMINE FLUORIDE GEL AND STANNOUS FLUORIDE GEL IN DEBRIDED PERIODONTAL POCKETS
VL - 18
Y2 - 4
ID - 15549
ER -
TY - JOUR
AB - The short-term bactericidal effect of 2% chlorhexidine gel, 4% stannous
fluoride gel or amine fluoride gel containing 1.25% fluoride on the subgingival
microflora was determined in 40 periodontal pockets of 10 patients. The
antimicrobial gels or placebo gel were applied in 5-9 mm deep periodontal pockets 3
times within 10 min. Before and 30 min after the applications, samples were taken
of the subgingival microflora for determination of the total number of bacteria as
well as the number of black pigmented Bacteroides. Reductions of the total number
of bacteria were found in all test groups. The reductions found in the pockets
treated with chlorhexidine gel or stannous fluoride gel were significantly greater
than the reduction found in the pockets treated with a placebo gel. A significant
reduction of black-pigmented Bacteroides was found after treatment with
chlorhexidine gel or amine fluoride gel. It is concluded that 2% chlorhexidine gel
or 4% stannous fluoride gel has a more than 99% reduction effect on the microflora
of periodontal pockets within 30 min after application.
AN - rayyan-563562042
AU - Mikx, F. H. M.
AU - Vanthof, M. A.
AU - Renggli, H. H.
DO - 10.1111/j.1600-051X.1991.tb01696.x
IS - 2
PY - 1991
SN - 0303-6979
SP - 97-100
ST - SHORT-TERM BACTERICIDAL ACTIVITY OF CHLORHEXIDINE GEL, STANNOUS FLUORIDE GEL
AND AMINE FLUORIDE GEL TESTED IN PERIODONTAL POCKETS
TI - SHORT-TERM BACTERICIDAL ACTIVITY OF CHLORHEXIDINE GEL, STANNOUS FLUORIDE GEL
AND AMINE FLUORIDE GEL TESTED IN PERIODONTAL POCKETS
VL - 18
Y2 - 2
ID - 15416
ER -
TY - JOUR
AB - The clinical and microbiological effect of locally-applied chlorhexidine gel
2%, amine fluoride gel 1.25%, stannous fluoride gel 4% or placebo gel in 40
periodontal pockets of 10 patients were studied. The gels were applied 3 x within
10 min. after mechanical debridement of the pockets. The treatment effect on the
subgingival microflora was evaluated by microscopic and culture studies of the
subgingival plaque samples. In addition, supragingival plaque, bleeding after
probing and probing pocket depth were scored. Examination were carried out before
and during a period of 36 weeks after treatment. At the start, the cultured
microflora consisted mainly of anaerobic Gram-positive bacteria. Following
treatment, the clinical parameters were significantly reduced. Concomitantly, the
%s of spirochetes, motile rods and non-motile rods decreased significantly. A
significant decrease was also found in the total anaerobic count, whereas the
facultative counts remained at the same level found before treatment. This
suggested that the treatment resulted in a mainly facultative subgingival
microflora. The % Gram-negative rods showed a significant reduction after
treatment, but returned to base line at week 12. Statistical analysis of the
bacteriological and clinical examinations failed to demonstrate any significant
differences between the 4 treatment groups. Thus, in comparison to the placebo gel,
subgingival application of chlorhexidine gel 2%, amine fluoride gel 1.25% or
stannous fluoride gel 4% did not augment the effect of mechanical debridement on
bacteriological and clinical parameters during the experimental period of 36 weeks.
However the indicated treatments resulted in a facultative subgingival microflora
which is compatible with the host.
AN - rayyan-563561090
AU - Oosterwaal, P. J.
AU - Mikx, F. H.
AU - van 't Hof, M. A.
AU - Renggli, H. H.
DO - 10.1111/j.1600-051x.1991.tb00422.x
IS - 4
KW - Adult
Amines/administration & dosage/*therapeutic use
Bacteria/*drug effects/isolation & purification
Chlorhexidine/administration & dosage/*therapeutic use
Dental Plaque/microbiology/prevention & control
Diamines
Double-Blind Method
Female
Fluorides/administration & dosage/*therapeutic use
Gels
Gingival Hemorrhage/prevention & control
Humans
Male
Middle Aged
Periodontal Pocket/*drug therapy/microbiology
Periodontitis/drug therapy/microbiology
Placebos
Subgingival Curettage
Tin Fluorides/administration & dosage/*therapeutic use
Ultrasonic Therapy
LA - eng
N1 - Department of Periodontology and Preventive Dentistry, University of
Nijmegen, The Netherlands.
PY - 1991
SN - 0303-6979 (Print)
SP - 245-51
VL - 18
Y2 - 4
ID - 14464
ER -
TY - JOUR
AB - The short-term bactericidal effect of 2% chlorhexidine gel, 4% stannous
fluoride gel or amine fluoride gel containing 1.25% fluoride on the subgingival
microflora was determined in 40 periodontal pockets of 10 patients. The
antimicrobial gels or placebo gel were applied in 5-9 mm deep periodontal pockets 3
times within 10 min. Before and 30 min after the applications, samples were taken
of the subgingival microflora for determination of the total number of bacteria as
well as the number of black pigmented Bacteroides. Reductions of the total number
of bacteria were found in all test groups. The reductions found in the pockets
treated with chlorhexidine gel or stannous fluoride gel were significantly greater
than the reduction found in the pockets treated with a placebo gel. A significant
reduction of black-pigmented Bacteroides was found after treatment with
chlorhexidine gel or amine fluoride gel. It is concluded that 2% chlorhexidine gel
or 4% stannous fluoride gel has a more than 99% reduction effect on the microflora
of periodontal pockets within 30 min after application.
AN - rayyan-563561135
AU - Mikx, F. H.
AU - van 't Hof, M. A.
AU - Renggli, H. H.
DO - 10.1111/j.1600-051x.1991.tb01696.x
IS - 2
KW - Adult
Amines/administration & dosage/*therapeutic use
Bacteria/*drug effects/isolation & purification
Chlorhexidine/administration & dosage/*therapeutic use
Dental Plaque/microbiology
Diamines
Double-Blind Method
Female
Fluorides/administration & dosage/*therapeutic use
Gels
Humans
Male
Methylcellulose
Middle Aged
Periodontal Pocket/drug therapy/*microbiology
Placebos
Tin Fluorides/administration & dosage/*therapeutic use
LA - eng
N1 - Department of Periodontology and Preventive Dentistry, University of
Nijmegen, The Netherlands.
PY - 1991
SN - 0303-6979 (Print)
SP - 97-100
ST - Short-term bactericidal activity of chlorhexidine gel, stannous fluoride gel
TI - Short-term bactericidal activity of chlorhexidine gel, stannous fluoride gel
VL - 18
Y2 - 2
ID - 14509
ER -
TY - JOUR
AB - In vitro inhibitory and bactericidal concentrations in serum of
chlorhexidine-digluconate, amine fluoride gel, stannous fluoride gel, stannous
fluoride, metronidazole and amoxicillin were determined against Bacteroides
gingivalis, Bacteroides intermedius, Fusobacterium nucleatum, Actinobacillus
actinomycetemcomitans and Capnocytophaga sputigena. The minimal inhibitory
concentration was assessed by the agar dilution technique. The killing curves and
minimal bactericidal concentration of the antimicrobial agents in inactivated
bovine serum were determined after 5, 10, 20 and 60 minutes contact time. The
minimal inhibitory concentration varied amongst the tested bacteria. A
concentration of 128 micrograms/ml chlorhexidine digluconate, 20 mg/ml amine
fluoride gel, 1 mg/ml stannous fluoride, 128 micrograms/ml metronidazole and 4
micrograms/ml amoxicillin inhibited the growth of the tested species. The minimal
bactericidal concentration in serum for B. gingivalis, B. intermedius, F.
nucleatum, A. actinomycetemcomitans and C. sputigena after 10 min contact time was
5 mg/ml for chlorhexidine digluconate and 100 mg/ml for amine fluoride gel. A
concentration of 200 mg/ml stannous fluoride gel in serum was bactericidal for the
tested species after 10 min contact time, with exception of F. nucleatum.
AN - rayyan-563561307
AU - Mikx, F. H.
AU - van den Brink, M. E.
AU - Renggli, H. H.
DO - 10.1111/j.1600-0765.1989.tb00871.x
IS - 2
KW - Actinobacillus/drug effects
Actinomyces/drug effects
Amines/*administration & dosage
Amoxicillin/administration & dosage
Capnocytophaga/drug effects
Chlorhexidine/administration & dosage/*analogs & derivatives
Diamines
Fluorides/*administration & dosage
Fusobacterium/drug effects
Gels
Metronidazole/administration & dosage
Time Factors
Tin Fluorides/*administration & dosage
LA - eng
PY - 1989
SN - 0022-3484 (Print)
SP - 155-60
ST - Bactericidal concentrations of chlorhexidine-digluconate, amine fluoride gel
times
TI - Bactericidal concentrations of chlorhexidine-digluconate, amine fluoride gel
times
VL - 24
Y2 - 3
ID - 14681
ER -
TY - JOUR
AB - Introduction: The purpose of this study was to evaluate the antimicrobial
activity of calcium hydroxide, 2% chlorhexidine gel, and triantibiotic paste (ie,
metronidazole, minocycline, and ciprofloxacin) by using an intraorally infected
dentin biofilm model. Methods: Forty bovine dentin specimens were infected
intraorally using a removable orthodontic device in. order to induce the biofilm
colonization of the dentin. Then, the samples were treated with the medications for
7 days. Saline solution was used as the control. Two evaluations were performed:
immediately after the elimination of the medication and after incubation in brain-
heart infusion medium for 24 hours. The Live/Dead technique (Invitrogen, Eugene,
OR) and a confocal microscope were used to obtain the percentage of live cells.
Nonparametric statistical tests were performed to show differences in the
percentage of live cells among the groups (P < .05). Results: Calcium hydroxide and
2% chlorhexidine gel did not show statistical differences in the immediate
evaluation. However, after application of the brain-heart infusion medium for 24
hours, 2% gel chlorhexidine showed a statistically lesser percentage of live cells
in comparison with calcium hydroxide. The triantibiotic paste significantly showed
a lower percentage of live cells in comparison with the 2% chlorhexidine gel and
calcium hydroxide groups in the immediate and secondary (after 24 hours)
evaluations. Conclusions: The triantibiotic paste was most effective at killing the
bacteria in the biofilms on the intraorally infected dentin model in comparison
with 2% chlorhexidine gel and calcium hydroxide. (J Endod 2013;39:115-118)
AN - rayyan-563562451
AU - Ordinola-Zapata, R.
AU - Bramante, C. M.
AU - Minotti, P. G.
AU - Cavenago, B. C.
AU - Garcia, R. B.
AU - Bernardineli, N.
AU - Jaramillo, D. E.
AU - Duarte, M. A. H.
DO - 10.1016/j.joen.2012.10.004
IS - 1
PY - 2013
SN - ["0099-2399", "1878-3554"]
SP - 115-118
ST - Antimicrobial Activity of Triantibiotic Paste, 2% Chlorhexidine Gel, and
Calcium Hydroxide on an Intraoral-infected Dentin Biofilm Model
TI - Antimicrobial Activity of Triantibiotic Paste, 2% Chlorhexidine Gel, and
Calcium Hydroxide on an Intraoral-infected Dentin Biofilm Model
VL - 39
Y2 - 1
ID - 15825
ER -
TY - JOUR
AB - Background: Tooth whitening is one of the most requested dental treatments,
but it still presents some side effects. Indeed, the bleaching agent can generate
patients’ discomfort and dental hard tissue damages, not achieving an efficient and
long-lasting treatment with optimum whitening effect. To overcome these
limitations, the bleaching agents containing nano-hydroxyapatite can represent a
reliable solution to avoid these detrimental effects. Methods: In this study, human
third molars were treated with commercial bleaching agents, containing nano-
hydroxyapatite (nHA) and 6% (at-home treatment), 12% and 18% (in-office treatments)
of hydrogen peroxide (HP), named respectively G1, G2 and G3. The results were
evaluated descriptively and analytically using Attenuated Total Reflectance-Fourier
Transform Infrared Spectroscopy (ATR-FTIR), Scanning Electron Microscopy (SEM) and
Energy Dispersive X-ray spectroscopy (EDS), comparing the treated groups with a
commercial gel containing 10% carbamide peroxide (CONV) and with a non-treated
control group (CTRL). Results: ATR-FTIR analysis revealed a similar composition in
carbonates and phosphates for CTRL, G1 and G2 groups, which showed no significant
differences in their spectral profiles; an increased amount of organic matter was
found in G3, while CONV displayed an intermediate behavior. SEM analysis did not
highlight significant changes in the enamel microstructure of G1 and CONV when
compared to CTRL; the pattern observed in G2 presented a slight increase of enamel
irregularities, while G3 displayed a partial removal of the aprismatic layer and
microporosities. No evident effects due to nHA were observed in the structure of
the hydroxyapatite component of G1, G2 and CONV, if compared to CTRL, while G3
showed a slight loss of crystallinity. In all groups, EDS identified slight changes
in the concentration of chemical elements O and Ca, while the Ca/P ratio was
similar when compared to CTRL. Conclusion: The obtained results suggest that the
application of the tested commercial bleaching agents, with a concentration of HP
up to 12%, does not alter the morphological and chemical composition of the enamel
surface and maintains its crystallinity.
AN - rayyan-563560026
AU - Orilisi, G.
AU - Tosco, V.
AU - Monterubbianesi, R.
AU - Notarstefano, V.
AU - Özcan, M.
AU - Putignano, A.
AU - Orsini, G.
DO - 10.7717/peerj.10606
KW - Isomet
orthodontic device
ATR protein
biowhiten
bleaching agent
calcium
carbamide peroxide
carbonic acid derivative
chlorine
endogenous compound
fluorine
hydrogen peroxide
hydroxyapatite
nanohydroxyapatite
novon
organic matter
oxygen
phosphate
phosphorous acid
sodium
tosylchloramide sodium
article
bone turnover
craniofacial malformation
crystal structure
dentin
drug stability
enamel
micromorphology
periodontal disease
plaque index
third molar
tooth root canal
X ray diffraction
LA - English
PY - 2021
SN - 2167-8359
ST - ATR-FTIR, EDS and SEM evaluations of enamel structure after treatment with
hydrogen peroxide bleaching agents loaded with nano-hydroxyapatite particles
T2 - PeerJ
TI - ATR-FTIR, EDS and SEM evaluations of enamel structure after treatment with
hydrogen peroxide bleaching agents loaded with nano-hydroxyapatite particles
VL - 9
ID - 13400
ER -
TY - JOUR
AN - rayyan-563561156
AU - Oscaby, F.
IS - 596
KW - chlorhexidine
formaldehyde
plant extract
adolescent
adult
aged
article
drug combination
gel
gingivitis
human
medicinal plant
middle aged
rhubarb
tooth plaque
LA - French
PY - 1992
SN - 0009-4838
SP - 23-25
ST - A chlorhexidine-rhubarb extract mixture for gingival inflammation
T2 - Intérêt de l'association chlorhexidine-extrait de rhubarbe sur l'inflammation
gingivale.
TI - A chlorhexidine-rhubarb extract mixture for gingival inflammation
VL - 62
ID - 14530
ER -
TY - JOUR
AB - PURPOSE: Antiseptic mouth rinses are widely recommended and marketed to
improve oral health. This article summarizes current studies on the comparative
effectiveness of selected antiseptic mouth rinses in controlling plaque and
gingivitis, as well as risks associated with daily exposure, including salivary
flow rate, oral cancer and wear of composite restorations. METHODS: Electronic
database searches were conducted using Google Scholar and PubMed to identify
articles comparing the effectiveness of 4 commercially marketed antiseptic mouth
rinses differing in active ingredients (0.12% chlorhexidine gluconate, essential
oils (menthol, thymol and eucalyptol) and methyl salicylate, 0.7% cetylpyridinium
chloride and 20% aloe vera gel) for controlling plaque and gingivitis. Criteria for
inclusion included controlled clinical trials and systematic reviews appearing in
English language publications evaluating the comparative effectiveness of the mouth
rinses in controlling plaque and gingivitis, as well as risks associated with daily
usage. RESULTS: The majority of studies have shown mouth rinses containing
chlorhexidine gluconate or essential oils and methyl salicylate provide clinically
significant anti-gingivitis and anti-plaque benefits. Cetylpyridinium chloride has
been found to provide only limited clinical benefits compared to inactive control
mouth rinse. Inadequate evidence is available to evaluate the clinical
effectiveness of aloe vera gel. Chlorhexidine, essential oils and cetylpyridinium
have been found to be safe. However, limited data are available on the effects of
the mouth rinse on wear patterns of dental restorations. Studies reviewed reported
no significant difference in salivary flow rate related to alcohol based mouth
rinse. CONCLUSION: Research supports the effectiveness of antiseptic mouth rinses
in reducing plaque and gingivitis as an adjunct to home care. Insufficient evidence
is available to support the claim that oral antiseptics can reduce the risk of
developing periodontitis or the rate of progression of periodontitis.
AN - rayyan-563560502
AU - Osso, D.
AU - Kanani, N.
IS - 1
KW - mouthwash
comparative study
tooth plaque
dental restoration wear
drug effect
gingivitis
health
human
mouth tumor
risk factor
saliva
LA - English
PY - 2013
SN - 1553-0205
SP - 10-18
ST - Antiseptic mouth rinses: an update on comparative effectiveness, risks and
recommendations
T2 - J Dent Hyg
TI - Antiseptic mouth rinses: an update on comparative effectiveness, risks and
recommendations
VL - 87
ID - 13876
ER -
TY - JOUR
AN - rayyan-563562150
AU - Otsuka, M.
AU - Endo, J.
AU - Hinode, D.
AU - Nagata, A.
AU - Maehara, R.
AU - Sato, M.
AU - Nakamura, R.
DO - 10.1111/j.1600-0765.1987.tb02060.x
IS - 6
PY - 1987
SP - 491-498
ST - Isolation and characterization of protease from culture supernatant of
Bacteroides gingivalis
TI - Isolation and characterization of protease from culture supernatant of
Bacteroides gingivalis
0023600976&doi=10.1111%2fj.1600-
0765.1987.tb02060.x&partnerID=40&md5=6afce6a61fec6748f4db34eab37e1eb2
VL - 22
ID - 15524
ER -
TY - JOUR
AB - After a biomaterial is implanted in a bone defect area, the immune response
and bacterial infection affect the success of bone regeneration. In this study, we
describe the development of a promising therapeutic approach to accelerate bone
regeneration via combining osteoimmunomodulatory and antibacterial activities.
Herein, we fabricated a nanosilver/halloysite nanotubes/gelatin methacrylate
(nAg/HNTs/GelMA) hybrid hydrogel and evaluated its osteoimmunomodulatory and
antibacterial properties in vitro and in vivo. The nAg/HNTs/GelMA hybrid hydrogel
had good biocompatibility with human periodontal ligament stem cells (hPDLSCs) and
macrophages. Moreover, the nAg/HNTs/GelMA hybrid hydrogel modulated inflammatory
cytokines secreted by macrophages and enhanced the osteogenic differentiation of
hPDLSCs in an inflammatory environment. In addition, nAg/HNTs/GelMA hybrid hydrogel
inhibited the growth of Gram-positive and Gram-negative bacteria in vitro and in
vivo. Compared with HNTs/GelMA hydrogel, the nAg/HNTs/GelMA hybrid hydrogel better
modulated the osteoimmune microenvironment and eliminated bacterial infection.
Thus, this hybrid hydrogel combining osteoimmunomodulatory with antibacterial
activities is a promising biomaterial for bone regeneration in defect areas.
AN - rayyan-563562174
AU - Ou, Q. M.
AU - Huang, K. Q.
AU - Fu, C. Q.
AU - Huang, C. L.
AU - Fang, Y. F.
AU - Gu, Z. P.
AU - Wu, J.
AU - Wang, Y.
DO - 10.1016/j.cej.2019.123019
PY - 2020
SN - ["1385-8947", "1873-3212"]
ST - Nanosilver-incorporated halloysite nanotubes/gelatin methacrylate hybrid
hydrogel with osteoimmunomodulatory and antibacterial activity for bone
regeneration
T2 - CHEMICAL ENGINEERING JOURNAL
TI - Nanosilver-incorporated halloysite nanotubes/gelatin methacrylate hybrid
regeneration
VL - 382
Y2 - 2 y3 - 15
ID - 15548
ER -
TY - JOUR
AN - rayyan-563561687
AU - Ou, Q.
AU - Huang, K.
AU - Fu, C.
AU - Huang, C.
AU - Fang, Y.
AU - Gu, Z.
AU - Wu, J.
AU - Wang, Y.
DO - 10.1016/j.cej.2019.123019
PY - 2020
ST - Nanosilver-incorporated halloysite nanotubes/gelatin methacrylate hybrid
regeneration
T2 - Chemical Engineering Journal
TI - Nanosilver-incorporated halloysite nanotubes/gelatin methacrylate hybrid
regeneration
85072793117&doi=10.1016%2fj.cej.2019.123019&partnerID=40&md5=ca61f03ea636a13e00f5cc
51b4849b08
VL - 382
ID - 15061
ER -
TY - JOUR
AB - The conservative technique of professionally dispensed and supervised, home-
administered vital bleaching is now a routine treatment in the dental profession.
This double-blind study evaluated the Rembrandt Lightening Gel and Whitening
Toothpaste for shade change, colorimeter shade change. As well, it evaluated soft
tissue health by periodontal probing, plaque index, and bleeding index. A patient
questionnaire evaluated perception of whitening, perception of oral hygiene,
average hours per day, and average days per week. Bleaching trays were worn over a
4-week period. The bleaching system showed definitive whitening effects as
evaluated with the Vita shade guide and the colorimeter. The bleaching system had
no deleterious effects on the soft tissue. The Rembrandt toothpaste alone
demonstrated two-shade lightening. This vital bleaching system shows definitive
whitening of the teeth in short periods of time with no adverse effects.
AN - rayyan-563561154
AU - Ouellet, D.
AU - Los, S.
AU - Case, H.
AU - Healy, R.
IS - 3
peroxide
toothpaste
urea
carbamide peroxide
article
clinical trial
color
controlled study
dental procedure
dental device
drug combination
gel
human
standard
tooth discoloration
tooth plaque
LA - English
PY - 1992
SN - 1040-1466
SP - 79-83
ST - Double-blind whitening Night-Guard study using ten percent carbamide peroxide
T2 - J Esthet Dent
TI - Double-blind whitening Night-Guard study using ten percent carbamide peroxide
VL - 4
ID - 14528
ER -
TY - JOUR
AB - PURPOSE: To explore the feasibility of adhesive thiomer calcium alginate
composite hydrogel (ZIF-8@CHA-SH) containing metal-organic framework for the
treatment of periodontitis in rats. METHODS: Preparation and characterization of
ZIF-8@CHA-SH were performed, and the morphology and chemical composition were
observed. The antibacterial properties were detected by plate coating method and
scanning electron microscope. CCK-8 and live/dead cell fluorescence staining were
used to evaluate the toxicity of ZIF-8@CHA-SH on gingival fibroblasts. The anti-
inflammatory and tissue repair promoting effects of ZIF-8@CHA-SH were verified by
animal experiments. GraphPad Prism 7.0 software was used for statistical analysis.
RESULTS: The successful synthesis of ZIF-8@CHA-SH was proved by scanning electron
microscopy, energy spectrum analysis, Fourier transform infrared spectroscopy and
X-ray diffraction. ZIF-8@CHA-SH had excellent antibacterial ability, and the
antibacterial rates against Escherichia coli, Staphylococcus aureus and
Streptococcus mutans were (99.88±0.12)%, (99.81±0.32)% and (95.53±3.08)%,
respectively（P<0.001）. The cell viability rate of ZIF-8@CHA-SH was (91.64±3.66)%
after 5 days of co-culture with human gingival fibroblasts (P=0.6). In vivo
experiments showed that ZIF-8@CHA-SH could reduce the infiltration of inflammatory
cells and the expression of pro-inflammatory factor IL-6 in rats with
periodontitis. CONCLUSIONS: ZIF-8@CHA-SH has excellent biological performance,
which can effectively treat periodontitis caused by bacteria, and provids a new
strategy for the treatment of periodontal diseases in the future.
AN - rayyan-563559821
AU - Ouyang, M.
AU - Wang, G. H.
IS - 4
KW - alginic acid
antiinfective agent
zeolite
zinc
animal
chemistry
human
hydrogel
periodontitis
rat
LA - Chinese
PY - 2022
SN - 1006-7248
SP - 379-383
ST - Application of sulfylated calcium alginate composite hydrogel loaded with
zinc-based zeolite imidazole for the treatment of periodontitis
TI - Application of sulfylated calcium alginate composite hydrogel loaded with
zinc-based zeolite imidazole for the treatment of periodontitis
VL - 31
ID - 13195
ER -
TY - JOUR
AB - PURPOSE: To explore the feasibility of adhesive thiomer calcium alginate
composite hydrogel (ZIF-8@CHA-SH) containing metal-organic framework for the
treatment of periodontitis in rats. METHODS: Preparation and characterization of
ZIF-8@CHA-SH were performed, and the morphology and chemical composition were
observed. The antibacterial properties were detected by plate coating method and
scanning electron microscope. CCK-8 and live/dead cell fluorescence staining were
used to evaluate the toxicity of ZIF-8@CHA-SH on gingival fibroblasts. The anti-
inflammatory and tissue repair promoting effects of ZIF-8@CHA-SH were verified by
animal experiments. GraphPad Prism 7.0 software was used for statistical analysis.
RESULTS: The successful synthesis of ZIF-8@CHA-SH was proved by scanning electron
microscopy, energy spectrum analysis, Fourier transform infrared spectroscopy and
X-ray diffraction. ZIF-8@CHA-SH had excellent antibacterial ability, and the
antibacterial rates against Escherichia coli, Staphylococcus aureus and
Streptococcus mutans were (99.88±0.12)%, (99.81±0.32)% and (95.53±3.08)%,
respectively（P<0.001）. The cell viability rate of ZIF-8@CHA-SH was (91.64±3.66)%
after 5 days of co-culture with human gingival fibroblasts (P=0.6). In vivo
experiments showed that ZIF-8@CHA-SH could reduce the infiltration of inflammatory
cells and the expression of pro-inflammatory factor IL-6 in rats with
periodontitis. CONCLUSIONS: ZIF-8@CHA-SH has excellent biological performance,
which can effectively treat periodontitis caused by bacteria, and provids a new
strategy for the treatment of periodontal diseases in the future.
AN - rayyan-563561407
AU - Ouyang, M.
AU - Wang, G. H.
IS - 4
J2 - Shanghai Kou Qiang Yi Xue
KW - Rats
Animals
Humans
Zinc
*Zeolites/chemistry
Hydrogels/chemistry
Alginates
Imidazoles/chemistry
LA - chi
N1 - Department of Stomatology, Putuo Affiliated Hospital of Shanghai University
of Traditional Chinese Medicine. Shanghai 200062, China. E-mail:
kouqiangke6401@163.com.
PY - 2022
SN - 1006-7248 (Print)
SP - 379-383
ST - [Application of sulfylated calcium alginate composite hydrogel loaded with
zinc-based zeolite imidazole for the treatment of periodontitis]
T2 - Shanghai kou qiang yi xue = Shanghai journal of stomatology
TI - [Application of sulfylated calcium alginate composite hydrogel loaded with
zinc-based zeolite imidazole for the treatment of periodontitis]
VL - 31
Y2 - 8
ID - 14781
ER -
TY - JOUR
AB - Background: Aberrant angiogenesis is associated with lesion formation in
chronic periodontitis. However, little is known about the mediators that contribute
to angiogenesis or about therapeutic agents that control the production of the
mediators. Roxithromycin (RXM), which is a new 14-member macrolide antibiotic, has
a wide antibacterial spectrum against oral pathogens and an immunomodulatory
effect. In the present study, we examined the effects of RXM on tumor necrosis
factor (TNF)-α-induced vascular endothelial growth factor (VEGF) in human
periodontal ligament (HPDL) cells. In addition, the effect of RXM on VEGF
expression in HPDL cells was examined. Methods: HPDL cells were plated at 5 x 105
cells/ml in 150 cm2 cell culture dishes. The confluent-stage cells were pretreated
with or without 10 μg/ml of RXM or other antibiotics in 1% FBS-containing α-MEM for
24 hours, followed by simultaneous treatment with 10 ng/ml of TNF-α and 10 μg/ml of
these antibiotics. After incubation for various periods, the culture supernatants
and sediments were collected and analyzed by ELISA, Northern blot, and gel shift
assays. Results: VEGF mRNA and its protein were constitutively expressed in HPDL
cells, and the level of expression was markedly enhanced by stimulation with TNF-α.
RXM strongly inhibited the expression of VEGF mRNA and the production of VEGF.
Furthermore, RXM suppressed activation of transcription factors AP-1 and SP-1,
which were critical factors in VEGF transcription, in TNF-α-stimulated HPDL cells.
Conclusion: These results indicate that TNF-α, one of the proinflammatory cytokines
implicated in the pathogenesis of periodontitis, induces excess induction of VEGF
in HPDL, which may account for increased angiogenesis in periodontitis lesions.
Interestingly, the antibiotic roxithromycin inhibits TNF-mediated VEGF induction,
suggesting its possible therapeutic utility in periodontitis and other chronic
inflammatory conditions involving VEGF induction.
AN - rayyan-563560932
AU - Oyama, T.
AU - Sakuta, T.
AU - Matsushita, K.
AU - Maruyama, I.
AU - Nagaoka, S.
AU - Torii, M.
DO - 10.1902/jop.2000.71.10.1546
IS - 10
KW - macrolide
messenger RNA
roxithromycin
transcription factor Sp1
vasculotropin
adult
article
case report
cell culture
chronic disease
controlled study
human
human cell
human tissue
immunomodulation
inflammation
male
Northern blotting
periodontitis
protein expression
supernatant
LA - English
PY - 2000
SN - 0022-3492
SP - 1546-1553
ST - Effects of roxithromycin on tumor necrosis factor-alpha- induced vascular
endothelial growth factor expression in human periodontal ligament cells in culture
TI - Effects of roxithromycin on tumor necrosis factor-alpha- induced vascular
VL - 71
ID - 14306
ER -
TY - JOUR
AB - BACKGROUND: Aberrant angiogenesis is associated with lesion formation in
chronic periodontitis. However, little is known about the mediators that contribute
to angiogenesis or about therapeutic agents that control the production of the
mediators. Roxithromycin (RXM), which is a new 14-member macrolide antibiotic, has
a wide antibacterial spectrum against oral pathogens and an immunomodulatory
effect. In the present study, we examined the effects of RXM on tumor necrosis
factor (TNF)-alpha-induced vascular endothelial growth factor (VEGF) in human
periodontal ligament (HPDL) cells. In addition, the effect of RXM on VEGF
expression in HPDL cells was examined. METHODS: HPDL cells were plated at 5 x 10(5)
cells/ml in 150 cm2 cell culture dishes. The confluent-stage cells were pretreated
with or without 10 microg/ml of RXM or other antibiotics in 1% FBS-containing
alpha-MEM for 24 hours, followed by simultaneous treatment with 10 ng/ml of TNF-
alpha and 10 microg/ml of these antibiotics. After incubation for various periods,
the culture supernatants and sediments were collected and analyzed by ELISA,
Northern blot, and gel shift assays. RESULTS: VEGF mRNA and its protein were
constitutively expressed in HPDL cells, and the level of expression was markedly
enhanced by stimulation with TNF-alpha. RXM strongly inhibited the expression of
VEGF mRNA and the production of VEGF. Furthermore, RXM suppressed activation of
transcription factors AP-1 and SP-1, which were critical factors in VEGF
transcription, in TNF-alpha-stimulated HPDL cells. CONCLUSION: These results
indicate that TNF-alpha, one of the proinflammatory cytokines implicated in the
pathogenesis of periodontitis, induces excess induction of VEGF in HPDL, which may
account for increased angiogenesis in periodontitis lesions. Interestingly, the
antibiotic roxithromycin inhibits TNF-mediated VEGF induction, suggesting its
possible therapeutic utility in periodontitis and other chronic inflammatory
conditions involving VEGF induction.
AN - rayyan-563561421
AU - Oyama, T.
AU - Sakuta, T.
AU - Matsushita, K.
AU - Maruyama, I.
AU - Nagaoka, S.
AU - Torii, M.
DO - 10.1902/jop.2000.71.10.1546
IS - 10
J2 - J Periodontol
KW - Adult
Blotting, Northern/methods
Cells, Cultured
Drug Interactions
Endothelial Growth Factors/analysis/*pharmacology
Enzyme-Linked Immunosorbent Assay/methods
Gene Expression Regulation/*drug effects
Humans
Lymphokines/analysis/*drug effects/*pharmacology
Male
Periodontal Ligament/cytology/*drug effects
Protein Isoforms/analysis/drug effects
RNA/isolation & purification
RNA, Messenger/analysis/drug effects
Roxithromycin/*pharmacology
Tumor Necrosis Factor-alpha/analysis/*drug effects
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
LA - eng
N1 - Department of Operative Dentistry and Endodontology, Kagoshima University
Dental School, Japan. macken@dentb.hal.kagoshima-u.ac.jp
PY - 2000
SN - 0022-3492 (Print)
SP - 1546-53
ST - Effects of roxithromycin on tumor necrosis factor-alpha-induced vascular
TI - Effects of roxithromycin on tumor necrosis factor-alpha-induced vascular
VL - 71
Y2 - 10
ID - 14795
ER -
TY - JOUR
AB - Periodontitis is an inflammatory disease associated with anaerobic bacteria
leading to the destruction of tooth-supporting tissues. Porphyromonas gingivalis is
a keystone anaerobic pathogen involved in the development of severe lesions.
Periodontal treatment aims to suppress subgingival biofilms and to restore tissue
homeostasis. However, hypoxia impairs wound healing and promotes bacterial growth
within periodontal pocket. This study aimed to evaluate the potential of local
oxygen delivery through the local application of a hydrogel containing Arenicola
marina's hemoglobin (M101). To this end, a hydrogel (xanthan (2%), hyaluronic acid
(1%)) containing M101 (1–2 g/L) (Xn(2%)-HA(1%)-M101) was prepared and
characterized. Rheological tests revealed the occurrence of high deformation
without the loss of elastic properties. Dialysis experiment revealed that
incorporation of M101 within the gel did not modify its oxygen transportation
properties. Samples of release media of the gels (1 g/L (10%) and 2 g/L (10%) M101)
decreased significantly the growth of P. gingivalis after 24 h validating its
antibacterial effect. Metabolic activity measurement confirmed the
cytocompatibility of Xn(2%)-HA(1%)-M101. This study suggests the therapeutic
interest of Xn(2%)-HA(1%)-M101 gel to optimize treatment of periodontitis with a
non-invasive approach.
AN - rayyan-563559974
AU - Özçelik, H.
AU - Batool, F.
AU - Corre, M.
AU - Garlaschelli, A.
AU - Conzatti, G.
AU - Stutz, C.
AU - Petit, C.
AU - Delpy, E.
AU - Zal, F.
AU - Leize-Zal, E.
AU - Huck, O.
DO - 10.1016/j.ijpharm.2021.120810
hemoglobin S
hyaluronic acid
hydrogel
m 101
unclassified drug
xanthan
Arenicola marina
article
controlled study
degradation
drug formulation
elasticity
flow kinetics
human
human cell
in vitro study
oxygen diffusion
oxygen transport
periodontitis
water content
LA - English
PY - 2021
SN - ["1873-3476", "0378-5173"]
ST - Characterization of a hyaluronic acid-based hydrogel containing an
extracellular oxygen carrier (M101) for periodontitis treatment: An in vitro study
T2 - Int. J. Pharm.
TI - Characterization of a hyaluronic acid-based hydrogel containing an
VL - 605
ID - 13348
ER -
TY - JOUR
AB - Periodontitis is an inflammatory disease associated with anaerobic bacteria
leading to the destruction of tooth supporting tissues. Porphyromonas gingivalis is
a keystone anaerobic pathogen involved in the development of severe lesions.
Periodontal treatment aims to suppress subgingival biofilms and to restore tissue
homeostasis. However, hypoxia impairs wound healing and promotes bacterial growth
within periodontal pocket. This study aimed to evaluate the potential of local
oxygen delivery through the local application of a hydrogel containing Arenicola
marina's hemoglobin (M101). To this end, a hydrogel (xanthan (2%), hyaluronic acid
(1%)) containing M101 (1-2 g/L) (Xn(2%)-HA(1%)-M101) was prepared and
characterized. Rheological tests revealed the occurrence of high deformation
without the loss of elastic properties. Dialysis experiment revealed that
incorporation of M101 within the gel did not modify its oxygen transportation
properties. Samples of release media of the gels (1 g/L (10%) and 2 g/L (10%) M101)
decreased significantly the growth of P. gingivalis after 24 h validating its
antibacterial effect. Metabolic activity measurement confirmed the
cytocompatibility of Xn(2%)HA(1%)-M101. This study suggests the therapeutic
interest of Xn(2%)-HA(1%)-M101 gel to optimize treatment of periodontitis with a
non-invasive approach.
AN - rayyan-563562028
AU - Ozcelik, H.
AU - Batool, F.
AU - Corre, M.
AU - Garlaschelli, A.
AU - Conzatti, G.
AU - Stutz, C.
AU - Petit, C.
AU - Delpy, E.
AU - Zal, F.
AU - Leize-Zal, E.
AU - Huck, O.
DO - 10.1016/j.ijpharm.2021.120810
PY - 2021
SN - ["0378-5173", "1873-3476"]
ST - Characterization of a hyaluronic acid-based hydrogel containing an
TI - Characterization of a hyaluronic acid-based hydrogel containing an
VL - 605
Y2 - 8 y3 - 10
ID - 15402
ER -
TY - JOUR
AB - Atorvastatin is a statin group HMG-CoA reductase inhibitor drug that is
commonly used to adverse cardiovascular events and to lower blood total cholesterol
and LDL-cholesterol. In recent years, atorvastatin has been reported to exert anti-
inflammatory activity and also inhibit degeneration of periodontal collagen fibers
in periodontal diseases. However, the solubility of atorvastatin in water is very
low (0.1 mg mL−1), which results in reduced bioavailability. In order to enhance
its solubility, we have prepared solid dispersions (SDs) of atorvastatin at
different drug: polymer ratios (1:9 and 1:12), using different polymers
(polyethylene glycol 6000 (PEG 6000), Pluronic F-68 (PL F-68), chitosan and
preparation methods (co-evaporation, melting, co-grinding and kneading). The
characterization of the SDs was performed using scanning electron microscopy (SEM),
differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy
(FTIR) and X-ray powder diffraction (XRD). Further, the atorvastatin SDs were
incorporated into chitosan gel at 2% concentration, intended for local application
in treatment of periodontal disease. The viscosity and bioadhesive property of the
gels were measured, and in vitro drug release studies were performed. Additionally,
the anti-inflammatory activity of the formulations was performed using tumor
necrosis factor (TNF)-alfa induced human gingival fibroblast (hGF) cells.
Proinflammatory cytokine (IL-1β, IL-6, IL-8) and anti-inflammatory cytokine (IL-10,
TGF-β1, TGF-β2, TGF-β3) levels were measured following application of the
formulations. A significant increase in solubility was achieved with the SDs. The
highest solubility was obtained with Pluronic F-68 using co-evaporation method at
1:12 ratio (5,55 mg/mL). Chitosan gels incorporated with SDs of atorvastatin
exhibited suitable viscosity and bioadhesive property for high retention time of
the drug at the application site. The drug release from the gels incorporated with
SDs of atorvastatin was found to be higher than that of crystalline atorvastatin in
chitosan gels. Decrease in cytokine levels was observed to be enhanced with the
with SDs incorporated into chitosan gel, indicating higher anti-inflammatory
activity. The preparation method used for SDs was found to have no significant
effect on cytokine levels.
AN - rayyan-563560023
AU - Özdoğan, A. I.
AU - Akca, G.
AU - Şenel, S.
DO - 10.1016/j.jddst.2020.102199
KW - atorvastatin
chitosan
distilled water
gel
interleukin 10
interleukin 1beta
interleukin 6
interleukin 8
low density lipoprotein cholesterol
macrogol 6000
poloxamer
water
article
controlled study
dispersion
drug formulation
drug release
drug solubility
fibroblast
gingiva
human
human cell
in vitro study
melting point
pH
tissue engineering
viscosity
water solubility
X ray diffraction
LA - English
PY - 2021
SN - 1773-2247
ST - Development and in vitro evaluation of gel formulation of atorvastatin solid
dispersions
TI - Development and in vitro evaluation of gel formulation of atorvastatin solid
dispersions
VL - 61
ID - 13397
ER -
TY - JOUR
AB - Revascularization of immature teeth with necrotic pulps traditionally
involves the use of triple antibiotic paste, which may sometimes lead to
undesirable complications. The objective of this study was to assess tissue repair
in immature dog teeth with apical periodontitis subjected to revascularization,
comparing two different pastes used for root canal disinfection. Apical
periodontitis was induced in 30 dog premolars. Teeth were randomly divided into
three experimental groups: root canals filled with triple antibiotic paste (n =
10); root canals filled with 1% propolis paste (n = 10); and no medication (n =
10). An additional group (n = 10, no intervention) was used as control. After 7
months, the jaws were histologically evaluated for the following variables: newly
formed mineralized tissue (present/absent); vital tissue in the canal space
(absent/periodontal ligament-like/pulp-like); apical extension of root
(present/absent); and severity of inflammatory process
(absent/mild/moderate/severe). There were no statistically significant differences
among the experimental groups in new mineralized tissue formation and apical root
development. The formation of vital tissue in the canal space, in turn, was
statistically different between the triple paste and propolis groups: vital tissues
were present in all revascularized teeth disinfected with propolis paste (100%),
compared to 71% of those disinfected with the triple paste. Severity of
inflammatory process was different between the triple paste and no medication
groups. The new tissues formed onto canal walls and in the root canal space showed
characteristics of cementum and periodontal ligament, respectively. Propolis may
have some advantages over the triple paste for the revascularization of immature
teeth.
AN - rayyan-563562499
AU - Pagliarin, C. M. L.
AU - Londero, C. D. D.
AU - Felippe, M. C. S.
AU - Felippe, W. T.
AU - Danesi, C. C.
AU - Barletta, F. B.
DO - 10.1590/1807-3107BOR-2016.vol30.0074
IS - 1
PY - 2016
SN - 1807-3107
ST - Tissue characterization following revascularization of immature dog teeth
using different disinfection pastes
T2 - BRAZILIAN ORAL RESEARCH
TI - Tissue characterization following revascularization of immature dog teeth
using different disinfection pastes
VL - 30
ID - 15873
ER -
TY - JOUR
AB - Introduction: This in vivo study used molecular microbiology methods to
evaluate the effects of passive ultrasonic irrigation (PUI) as a supplementary
disinfecting step after root canal preparation. Methods: Samples were taken from 10
necrotic root canals of teeth with apical periodontitis before (S1) and after
rotary nickel-titanium instrumentation using 2.5% NaOCl as the irrigant (S2) and
then after PUI for NaOCl activation (S3). The parameters examined included the
incidence of positive broad-range polymerase chain reaction (PCR) results for
bacterial presence, the impact on bacterial diversity evaluated by PCR-denaturing
gradient gel electrophoresis (DGGE), the quantitative bacterial reduction
determined by real-time PCR, and the identification of persistent species by clone
library analysis. Results: All S1 samples were positive for bacteria in all tests.
Treatment procedures were significantly effective in reducing the incidence of
positive results for bacteria, the number of bacterial cells (infectious
bioburden), and the bacterial diversity (number of species and abundance). However,
the supplementary PUI approach did not succeed in significantly enhancing
disinfection beyond that achieved by chemomechanical preparation. Several bacterial
species/phylotypes were identified in post-treatment samples that were positive for
bacteria. Conclusions: Findings from this clinical study including a small sample
size suggest that PUI can be ineffective in significantly improving disinfection of
the main root canal after chemomechanical procedures. Copyright © 2013 American
Association of Endodontists.
AN - rayyan-563560499
AU - Paiva, S. S. M.
AU - Rôças, I. N.
AU - Carmo, F. L.
AU - Leite, D. C. A.
AU - Ferreira, D. C.
AU - Rachid, C. T. C.
AU - Rosado, A. S.
DO - 10.1016/j.joen.2012.09.014
IS - 2
KW - bacterial RNA
dental alloy
hypochlorite sodium
nickel
RNA 16S
titanium
titanium nickelide
Actinobacteria
article
bacterial load
bacterium
Campylobacter
chemistry
dental surgery
drug effect
electrophoresis
endodontics
devices
human
lavage
methodology
microbiology
tooth pulp
tooth pulp disease
ultrasound
LA - English
PY - 2013
SN - 0099-2399
SP - 190-194
ST - Molecular microbiological evaluation of passive ultrasonic activation as a
supplementary disinfecting step: A clinical study
T2 - J. Endod.
TI - Molecular microbiological evaluation of passive ultrasonic activation as a
supplementary disinfecting step: A clinical study
VL - 39
ID - 13873
ER -
TY - JOUR
AB - Aim: To evaluate clinically the antibacterial effects of root canal treatment
procedures using molecular microbiology analyses. Methodology: Samples were taken
from 14 necrotic root canals of teeth with apical periodontitis before (S1) and
after instrumentation with NaOCl irrigation (S2), a final rinse with chlorhexidine
(CHX) (S3) and then one-week interappointment medication with calcium hydroxide/CHX
paste (S4). The parameters examined included the following: incidence of positive
broad-range PCR results for bacterial presence; impact on bacterial community
structures evaluated by PCR-Denaturing Gradient Gel Electrophoresis (DGGE);
quantitative bacterial reduction determined by real-time PCR; and identification of
bacterial persisters by cloning and sequencing. Data from the different tests were
subjected to statistical analyses and diversity indicator calculations. Results:
All S1 samples were positive for bacteria in all tests. Treatment procedures
promoted a decrease in microbial diversity and significantly reduced the incidence
of positive results and the bacterial counts (P<0.05). In general, each subsequent
treatment step improved disinfection. No specific taxon or community pattern was
associated with post-treatment samples. Conclusion: Supplementary steps consisting
of a final rinse with CHX followed by calcium hydroxide interappointment medication
promoted further decrease in the bacterial bioburden to levels significantly below
those achieved by the chemomechanical procedures alone. Because the long-term
outcome of root canal treatment is dependent upon maximal bacterial reduction, the
present results are of clinical relevance. © 2012 International Endodontic Journal.
AN - rayyan-563560493
AU - Rôças, I. N.
AU - Carmo, F. L.
AU - Rosado, A. S.
DO - 10.1111/j.1365-2591.2012.02111.x
IS - 3
KW - bacterial RNA
calcium hydroxide
chlorhexidine
dental alloy
drug derivative
edetic acid
hypochlorite sodium
nickel
RNA 16S
titanium
titanium nickelide
article
bacterial load
biodiversity
chemistry
classification
dental surgery
disinfection
drug effect
endodontics
devices
genetics
human
methodology
microbial consortium
microbiology
molecular biology
sequence analysis
tooth pulp
tooth pulp disease
LA - English
PY - 2013
SN - ["0143-2885", "1365-2591"]
SP - 225-233
ST - Clinical antimicrobial efficacy of NiTi rotary instrumentation with NaOCl
irrigation, final rinse with chlorhexidine and interappointment medication: A
molecular study
T2 - Int. Endod. J.
TI - Clinical antimicrobial efficacy of NiTi rotary instrumentation with NaOCl
irrigation, final rinse with chlorhexidine and interappointment medication: A
molecular study
VL - 46
ID - 13867
ER -
TY - JOUR
AB - Paiva SSM, Siqueira JF Jr, Rocas IN, Carmo FL, Leite DCA, Ferreira DC, Rachid
CTC, Rosado AS. Clinical antimicrobial efficacy of NiTi rotary instrumentation with
NaOCl irrigation, final rinse with chlorhexidine and interappointment medication: a
molecular study. International Endodontic Journal, 46, 225-233, 2013. Aim To
evaluate clinically the antibacterial effects of root canal treatment procedures
using molecular microbiology analyses. Methodology Samples were taken from 14
necrotic root canals of teeth with apical periodontitis before (S1) and after
instrumentation with NaOCl irrigation (S2), a final rinse with chlorhexidine (CHX)
(S3) and then one-week interappointment medication with calcium hydroxide/CHX paste
(S4). The parameters examined included the following: incidence of positive broad-
range PCR results for bacterial presence; impact on bacterial community structures
evaluated by PCR-Denaturing Gradient Gel Electrophoresis (DGGE); quantitative
bacterial reduction determined by real-time PCR; and identification of bacterial
persisters by cloning and sequencing. Data from the different tests were subjected
to statistical analyses and diversity indicator calculations. Results All S1
samples were positive for bacteria in all tests. Treatment procedures promoted a
decrease in microbial diversity and significantly reduced the incidence of positive
results and the bacterial counts (P<0.05). In general, each subsequent treatment
step improved disinfection. No specific taxon or community pattern was associated
with post-treatment samples. Conclusion Supplementary steps consisting of a final
rinse with CHX followed by calcium hydroxide interappointment medication promoted
further decrease in the bacterial bioburden to levels significantly below those
achieved by the chemomechanical procedures alone. Because the long-term outcome of
root canal treatment is dependent upon maximal bacterial reduction, the present
results are of clinical relevance.
AN - rayyan-563562438
AU - Rocas, I. N.
AU - Carmo, F. L.
AU - Rosado, A. S.
DO - 10.1111/j.1365-2591.2012.02111.x
IS - 3
PY - 2013
SN - ["0143-2885", "1365-2591"]
SP - 225-233
irrigation, final rinse with chlorhexidine and interappointment medication: a
molecular study
molecular study
VL - 46
Y2 - 3
ID - 15812
ER -
TY - JOUR
AB - AIM: To evaluate clinically the antibacterial effects of root canal treatment
procedures using molecular microbiology analyses. METHODOLOGY: Samples were taken
from 14 necrotic root canals of teeth with apical periodontitis before (S1) and
after instrumentation with NaOCl irrigation (S2), a final rinse with chlorhexidine
(CHX) (S3) and then one-week interappointment medication with calcium hydroxide/CHX
paste (S4). The parameters examined included the following: incidence of positive
broad-range PCR results for bacterial presence; impact on bacterial community
structures evaluated by PCR-Denaturing Gradient Gel Electrophoresis (DGGE);
quantitative bacterial reduction determined by real-time PCR; and identification of
bacterial persisters by cloning and sequencing. Data from the different tests were
subjected to statistical analyses and diversity indicator calculations. RESULTS:
All S1 samples were positive for bacteria in all tests. Treatment procedures
promoted a decrease in microbial diversity and significantly reduced the incidence
of positive results and the bacterial counts (P < 0.05). In general, each
subsequent treatment step improved disinfection. No specific taxon or community
pattern was associated with post-treatment samples. CONCLUSION: Supplementary steps
consisting of a final rinse with CHX followed by calcium hydroxide interappointment
medication promoted further decrease in the bacterial bioburden to levels
significantly below those achieved by the chemomechanical procedures alone. Because
the long-term outcome of root canal treatment is dependent upon maximal bacterial
reduction, the present results are of clinical relevance.
AN - rayyan-563561426
AU - Paiva, S. S.
AU - Rôças, I. N.
AU - Carmo, F. L.
AU - Leite, D. C.
AU - Rachid, C. T.
AU - Rosado, A. S.
DO - 10.1111/j.1365-2591.2012.02111.x
IS - 3
J2 - Int Endod J
KW - Anti-Infective Agents, Local/*therapeutic use
Biodiversity
Calcium Hydroxide/*therapeutic use
Chlorhexidine/*analogs & derivatives/therapeutic use
Denaturing Gradient Gel Electrophoresis
*Dental Alloys/chemistry
Dental Pulp/microbiology
Dental Pulp Necrosis/microbiology/therapy
Disinfection/*methods
Edetic Acid/therapeutic use
Gram-Negative Bacteria/classification/genetics
Gram-Positive Bacteria/classification/genetics
Humans
Microbial Consortia/drug effects
Molecular Biology
*Nickel/chemistry
Periapical Periodontitis/microbiology/therapy
RNA, Bacterial/analysis
RNA, Ribosomal, 16S/analysis
Real-Time Polymerase Chain Reaction
Root Canal Preparation/*instrumentation/methods
Sequence Analysis, RNA
Smear Layer
Sodium Hypochlorite/*therapeutic use
*Titanium/chemistry
LA - eng
N1 - Institute of Microbiology Prof. Paulo de Góes, Federal University of Rio de
Janeiro, Brazil.
PY - 2013
SP - 225-33
molecular study
T2 - International endodontic journal
molecular study
VL - 46
Y2 - 3
ID - 14800
ER -
TY - JOUR
AB - Hyptis pectinata (L.) Poit., Lamiaceae, is an aromatic, abundant and broadly
used plant species in Sergipeto treat oral and gastrointestinal pain and
inflammation. The aim of the present study was to analyze therelation between
periodontitis and changes in the corporal mass and alveolar bone structure after
induc-tion of experimental periodontal disease in rat treated or not treated with
H. pectinata gel at 5% (GS5%)and 10% (GS10%), comparing their effects with
doxycycline gel at 10% (D10%, positive control), vehiclegel (negative control) and
a group with experimental periodontal disease, but non-treated. The gels
werelocally applied in the gingival region immediately after the experimental
periodontal disease inductionby ligature (3×/day, 11 days). Bone destruction was
determined through clinical exam, histopathologicalanalysis and cone beam computed
tomography of the experimental animals (n = 36). After 11 days of peri-odontitis
induction, all groups that received ligature presented a decrease in the corporal
mass, exceptto the naïve group (without experimental periodontal disease) (p <
0.05). Computed tomography resultshave shown healthy bone structure in the group I
and bone resorption for the test groups. Histopathologi-cal analysis confirmed the
healthy bone structure for naïve group animals, while the test groups exhibitedbone
loss in several degrees. In particular, the non-treated group animals had an
intense inflammatoryprocess. When the periodontium of the animals treated with
GS10% was histopathologically analyzed,insertion periodontium was preserved. The
results for these groups were significantly different of thevehicle group (p <
0.05). According to the results, the gel based in the aqueous extract of H.
pectinata at10% can prevent bone loss in experimental periodontal disease similarly
to doxycycline 10%.
AN - rayyan-563560398
AU - Paixão, M. S.
AU - Melo, M. S.
AU - Damascena, N. P.
AU - Araújo, A. A. S.
AU - Soares, A. F.
AU - Oliveira, D. V. A.
AU - Oliveira, J. S.
AU - Almeida, F. T. C.
AU - Amaral, F. S.
AU - Araújo, B. S.
AU - Estevam, C. S.
AU - Botelho, M. A.
AU - Quintans-Júnior, L. J.
DO - 10.1016/j.bjp.2014.12.002
IS - 1
KW - doxycycline
Hyptis pectinata extract
plant extract
unclassified drug
animal experiment
animal model
animal tissue
article
bone structure
controlled study
gel
histopathology
Lamiaceae
nonhuman
osteolysis
periodontitis
rat
LA - English
PY - 2015
SN - 1981-528X
SP - 35-41
ST - Hyptis pectinata gel prevents alveolar bone resorption in experimental
periodontitis in rats
T2 - Rev. Brasileira Farmacognosia
TI - Hyptis pectinata gel prevents alveolar bone resorption in experimental
periodontitis in rats
VL - 25
ID - 13772
ER -
TY - JOUR
AB - Injectable thermosensitive chitosan hydrogel is an attractive temperature-
induced sol-gel solution that is widely used in drug delivery and biomedical
applications. In this study, an injectable antimicrobial delivery system for
periodontal treatment based on chitosan/gelatin/β-glycerolphosphate solution has
been developed. The result of thermal and mechanical evaluations of
chitosan/gelatin/β-glycerolphosphate hydrogel showed that adding gelatin to
chitosan/β-glycerolphosphate solution significantly decreased gelling time and
increased gel strength at 37°. The antimicrobial agents chosen for release studies
were metronidazole with a low molecular weight and vancomycin hydrochloride with a
high molecular weight. The initial burst and total in vitro drug release for
metronidazole was 13% and 67%, respectively. The initial burst and total drug
release for vancomycin hydrochloride was relatively low at 3% and 23%,
respectively. The momentary and total percentage of metronidazole accumulated in
the phosphate buffer revealed that chitosan/gelatin/β-glycerolphosphate can develop
and maintain sustained release of metronidazole in concentrations that are
effective for eliminating pathogenic bacteria over time. Cytotoxicity evaluations
show that chitosan/gelatin/β-glycerolphosphate thermosensitive hydrogel is a drug
carrier with no cytotoxic effects.
AN - rayyan-563560355
AU - Pakzad, Y.
AU - Ganji, F.
DO - 10.1177/0885328215614191
IS - 7
KW - chitosan
gelatin
glycerophosphate
metronidazole
vancomycin
acidity
article
biocompatibility
cell growth
cell survival
cell viability
drug cytotoxicity
drug formulation
drug release
gelation
heat sensitivity
human
human cell
hydrogel
hydrogen bond
hydrophobicity
in vitro study
ionic strength
molecular weight
pH
priority journal
slow release formulation
temperature
viscosity
body weight loss
LA - English
PY - 2016
SN - ["1530-8022", "0885-3282"]
SP - 919-929
ST - Thermosensitive hydrogel for periodontal application: In vitro drug release,
antibacterial activity and toxicity evaluation
T2 - J. Biomater. Appl.
TI - Thermosensitive hydrogel for periodontal application: In vitro drug release,
VL - 30
ID - 13729
ER -
TY - JOUR
periodontal treatment based on chitosan/gelatin/beta-glycerolphosphate solution has
chitosan/gelatin/beta-glycerolphosphate hydrogel showed that adding gelatin to
chitosan/beta-glycerolphosphate solution significantly decreased gelling time and
increased gel strength at 37 degrees C. The antimicrobial agents chosen for release
studies were metronidazole with a low molecular weight and vancomycin hydrochloride
with a high molecular weight. The initial burst and total invitro drug release for
the phosphate buffer revealed that chitosan/gelatin/beta-glycerolphosphate can
develop and maintain sustained release of metronidazole in concentrations that are
show that chitosan/gelatin/-glycerolphosphate thermosensitive hydrogel is a drug
AN - rayyan-563562026
AU - Pakzad, Y.
AU - Ganji, F.
DO - 10.1177/0885328215614191
IS - 7
PY - 2016
SN - ["0885-3282", "1530-8022"]
SP - 919-929
ST - Thermosensitive hydrogel for periodontal application: invitro drug release,
T2 - JOURNAL OF BIOMATERIALS APPLICATIONS
TI - Thermosensitive hydrogel for periodontal application: invitro drug release,
VL - 30
Y2 - 2
ID - 15400
ER -
TY - JOUR
periodontal treatment based on chitosan/gelatin/β-glycerolphosphate solution has
chitosan/gelatin/β-glycerolphosphate hydrogel showed that adding gelatin to
chitosan/β-glycerolphosphate solution significantly decreased gelling time and
increased gel strength at 37℃. The antimicrobial agents chosen for release studies
were metronidazole with a low molecular weight and vancomycin hydrochloride with a
high molecular weight. The initial burst and total in vitro drug release for
the phosphate buffer revealed that chitosan/gelatin/β-glycerolphosphate can develop
and maintain sustained release of metronidazole in concentrations that are
show that chitosan/gelatin/β-glycerolphosphate thermosensitive hydrogel is a drug
AN - rayyan-563560803
AU - Pakzad, Y.
AU - Ganji, F.
DO - 10.1177/0885328215614191
IS - 7
J2 - J Biomater Appl
KW - Anti-Bacterial Agents/*administration & dosage/*chemistry
Chitosan/*chemistry
Drug Carriers/chemistry
Gelatin/chemistry
Glycerophosphates/chemistry
HEK293 Cells
Humans
Hydrogels/*chemistry
Metronidazole/*administration & dosage/*chemistry
Molecular Weight
Periodontics/*methods
Phosphates/chemistry
Rheology
Solutions
Temperature
Vancomycin/chemistry
LA - eng
N1 - Biomedical Engineering Group, Chemical Engineering Faculty, Tarbiat Modares
University, Tehran, Iran.; Biomedical Engineering Group, Chemical Engineering
Faculty, Tarbiat Modares University, Tehran, Iran fganji@modares.ac.ir.
PY - 2016
SP - 919-29
ST - Thermosensitive hydrogel for periodontal application: in vitro drug release,
T2 - Journal of biomaterials applications
TI - Thermosensitive hydrogel for periodontal application: in vitro drug release,
VL - 30
Y2 - 2
ID - 14177
ER -
TY - JOUR
AB - BACKGROUND: Chlorhexidine has shown anti-plaque and antimicrobial effects
when used as a mouthwash and appears to be effective when used as a topical
antiseptic agent. AIM: The present study aimed to compare the efficacy of
chlorhexidine gel coated dental floss with that of uncoated dental floss. METHODS:
This parallel, single-blinded, randomized controlled clinical trial Included 30
patients with moderate to severe gingivitis. The total population was randomly
divided into three groups, with ten patients in each group. Group A received dental
floss with 1% chlorhexidine gel, and Group B received only dental floss, while in
Group C no dental floss was provided. All thirty volunteers were provided with
standard toothpaste and toothbrush. Clinical parameters such as gingival index,
plaque index, and bleeding index were recorded along with supragingival plaque
sample collection for microbiological culture. Subjects were recalled after 15 days
and clinical and microbiological analysis was performed. All parameters were re-
assessed at the follow up visit after two weeks. RESULTS: All the groups showed a
significant reduction in values of plaque index, gingival index, and bleeding
index, as well as the microbial counts post-enrollment in the study. A significant
reduction in the bleeding indices was noticed in Group A in comparison to C (p <
0.05). CONCLUSIONS: The use of dental floss coated with 1% chlorhexidine gluconate
gel was effective as an interproximal aid for patients with moderate to severe
gingivitis.
AN - rayyan-563560147
AU - Pal, M.
AU - Kumar, S.
AU - Shenoy, P. A.
AU - Chaitanya, T. A. K.
AU - Pratibha, G.
AU - Bhat, G. S.
DO - 10.3889/oamjms.2020.4141
KW - dental floss
chlorhexidine
colgate
mouthwash
toothpaste
adult
article
biofilm
bleeding
clinical article
controlled study
drug efficacy
follow up
gingiva bleeding
gingival index
gingivitis
human
plaque index
tooth brushing
tooth plaque
LA - English
PY - 2020
SN - 1857-9655
SP - 118-123
ST - Evaluation of plaque removal efficacy of dental floss with/without
chlorhexidine gel coating in patients with gingivitis-a clinical and microbological
study
TI - Evaluation of plaque removal efficacy of dental floss with/without
chlorhexidine gel coating in patients with gingivitis-a clinical and microbological
study
VL - 8
ID - 13521
ER -
TY - CONF
AN - rayyan-563561815
AU - Pal, P.
AU - Nguyen, Q.
AU - Janorkar, A. V.
DA - 2019
SP - 205
ST - Drug-loaded elastin-like polypeptide-collagen composites for bone tissue
engineering
T2 - Transactions of the Annual Meeting of the Society for Biomaterials and the
Annual International Biomaterials Symposium
TI - Drug-loaded elastin-like polypeptide-collagen composites for bone tissue
engineering
85065389499&partnerID=40&md5=470405e5a83663f1629b8e506be4cbe1
VL - 40
ID - 15189
ER -
TY - JOUR
AB - RESULTS: The lumens of the root canals were completely filled with mineral
trioxide aggregate with evidence of a mineralized apical bridge between the root
canal walls in 83% of the samples in the apexification group. Vital vascularized
tissue was found in the REP groups; apical closure happened in 66.7% of these
treatments, and root growth was detected more often as an increase in thickness
(85.6%) than in length (45.6%). The greatest amount of mineralized tissue inside
the canal was observed in the BC group, with statistical significance compared with
the HA:CS and P:CS groups (P < .05). Further histologic evaluation revealed the
presence of apical papilla. CONCLUSIONS: The addition of chitosan scaffolds to
blood in regenerative procedures in dogs did not improve the formation of new
mineralized tissues along the root canal walls or the histologic evidence of the
regeneration of a pulp-dentin complex. INTRODUCTION: The aim of this study was to
evaluate histologically the newly formed tissues after regenerative endodontic
procedures (REPs) in dogs using either a blood clot (BC) or 2 different
formulations of a chitosan hydrogel as scaffolds. METHODS: Apical periodontitis was
induced by inoculating immature teeth with oral plaque in 4 beagle dogs. Teeth (n =
96) were divided into 2 control (n = 20) and 4 test groups (n = 76) according to
the treatment: apexification and REPs with BC, sodium hyaluronate:chitosan (HA:CS)
scaffolds, or pectin:chitosan (P:CS) scaffolds. All root canals were disinfected
with 2.5% sodium hypochlorite and a triple antibiotic paste intracanal medicament
before evoked bleeding, clot formation, or scaffold placement. Thirteen weeks after
treatment, the animals were sacrificed and the jaw blocks harvested for histologic
processing, histomorphometric analysis, and statistical analysis.
AN - rayyan-563560294
AU - Palma, P. J.
AU - Ramos, J. C.
AU - Martins, J. B.
AU - Diogenes, A.
AU - Figueiredo, M. H.
AU - Ferreira, P.
AU - Viegas, C.
AU - Santos, J. M.
DO - 10.1016/j.joen.2017.03.005
IS - 8
KW - aluminum derivative
calcium derivative
chitosan
hyaluronic acid
hypochlorite sodium
oxide
silicate
animal
apexification
blood clotting
dog
drug combination
hydrogel
pharmacology
physiology
procedures
regeneration
tissue scaffold
tooth pulp disease
LA - English
PY - 2017
SN - 1878-3554
SP - 1279-1287
ST - Histologic Evaluation of Regenerative Endodontic Procedures with the Use of
Chitosan Scaffolds in Immature Dog Teeth with Apical Periodontitis
T2 - J Endod
TI - Histologic Evaluation of Regenerative Endodontic Procedures with the Use of
Chitosan Scaffolds in Immature Dog Teeth with Apical Periodontitis
VL - 43
ID - 13668
ER -
TY - JOUR
AB - OBJECTIVE: To compare clinical and microbiological responses following non-
surgical treatment of moderate to advanced adult periodontitis using subgingival
scaling with and without adjunctive topical or systemic metronidazole. DESIGN: A
single blind randomised clinical trial of 90 subjects, stratified for periodontitis
disease severity and smoking status, divided into three treatment groups: 1.
Subgingival scaling using ultrasonic scalers and local anaesthesia; 2. Subgingival
scaling using ultrasonic scalers and local anaesthesia plus seven days of systemic
metronidazole (200 mg tds); 3. Subgingival scaling using ultrasonic scalers and
local anaesthesia plus two applications of 25% metronidazole gel one week apart in
all sites with probing depths more than 4 mm. Evaluations were made before
treatment, and 8 weeks and 24 weeks post treatment. MAIN OUTCOME MEASURES: Probing
depths, probing attachment levels and bleeding on probing were measured using a
Florida probe. Bacterial morphotypes were evaluated with darkfield microscopy.
Results were analysed for all sites with baseline probing depths equal to or
greater than Florida probe recordings of 4.6 mm using analysis of variance.
RESULTS: 84 subjects completed the trial and the three treatment groups did not
differ at baseline for any clinical parameter. Mean probing depths were reduced
following treatment by greater than 1.6 mm (Group 1 = 1.68 mm, Group 2 = 1.62 mm,
Group 3 = 1.74 mm at six months post treatment) but no significant differences were
detected between treatment groups at any time point. Similarly, no significant
differences were detectable between treatments for changes in mean probing
attachment levels, bleeding on probing, plaque scores or proportions of bacterial
morphotypes. CONCLUSIONS: This study does not support the routine use of adjunctive
metronidazole in the non-surgical treatment of periodontitis.
AN - rayyan-563561027
AU - Palmer, R. M.
AU - Matthews, J. P.
AU - Wilson, R. F.
IS - 11
KW - acylglycerol
drug derivative
Elyzol Dentalgel
metronidazole
sesame seed oil
adult
aged
article
clinical trial
controlled study
female
human
male
microbiology
middle aged
outcome assessment
periodontics
periodontitis
tooth plaque
LA - English
PY - 1998
SN - 0007-0610
SP - 548-552
ST - Adjunctive systemic and locally delivered metronidazole in the treatment of
periodontitis: a controlled clinical study
T2 - Br Dent J
TI - Adjunctive systemic and locally delivered metronidazole in the treatment of
periodontitis: a controlled clinical study
VL - 184
ID - 14401
ER -
TY - JOUR
AB - AIM: To determine whether adjunctive metronidazole therapy would compensate
for the poorer treatment response to scaling and root planing reported in smokers.
METHOD: A single-blind, randomised clinical trial of 28 smokers and 56 non-smokers,
stratified for periodontitis disease severity and randomly allocated to 3 treatment
groups: (1) Scaling and root planing using an ultrasonic scaler with local
anaesthesia (SRP), (2) SRP+ metronidazole tabs 200 mg tds for 7 days, (3) SRP + 2
subgingival applications of 25% metronidazole gel. Probing depths (PD) and
attachment levels (AL) were recorded with a Florida probe at baseline, 2 months and
6 months post treatment by a single examiner who was unaware of the treatment
modality. Results were analysed for all sites with baseline probing depths equal to
or greater than Florida probe recordings of 4.6 mm using analysis of variance.
RESULTS: Reductions in probing depth at 6 months were significantly less (p <
0.001) in the smokers (mean 1.23 mm, 95% confidence intervals = 1.05 to 1.40 mm)
than in the non-smokers (1.92, 1.75 to 2.09 mm). Attachment level gains were
approximately 0.55 mm and there was no statistically significant difference between
smokers and non-smokers. There were no differences in any clinical measure in
response to the three treatment regimens at 2 or 6 months for either smokers or
non-smokers. A reduction in the proportion of spirochaetes was observed at 6 months
which was less in smokers than in non-smokers (p = 0.034). Multiple linear
regression analysis on probing depth at 6 months demonstrated that smoking was a
significant explanatory factor (p < 0.001) for poor treatment outcome, whilst the
presence or absence of adjunctive metronidazole was not (p = 0.620). CONCLUSION:
This study confirms that smokers have a poorer treatment response to SRP,
regardless of the application of either systemic or locally applied adjunctive
metronidazole.
AN - rayyan-563561011
AU - Palmer, R. M.
AU - Matthews, J. P.
AU - Wilson, R. F.
IS - 3
metronidazole
adult
aged
article
clinical trial
confidence interval
controlled study
drug effect
female
follow up
gel
human
male
microbiology
middle aged
pathophysiology
periodontal disease
periodontitis
smoking
spirochete
statistical model
tablet
ultrasound therapy
LA - English
PY - 1999
SN - 0303-6979
SP - 158-163
ST - Non-surgical periodontal treatment with and without adjunctive metronidazole
in smokers and non-smokers
TI - Non-surgical periodontal treatment with and without adjunctive metronidazole
in smokers and non-smokers
VL - 26
ID - 14385
ER -
TY - JOUR
AB - OBJECTIVES: Despite the excellent properties of both pure bioglasses (BG) and
BG doped with therapeutic ions (such as Li) in hard tissue applications, there is
not enough information about their role in the remineralization and bacterial-
growth in oral diseases. The aim of this contribution is to evaluate the effect of
both pure BG and BG doped with 5-wt% of Li (BGLi) on both the remineralization of
in vitro demineralized human-teeth and the antimicrobial behavior against strains
from caries and periodontitis. METHODS: Bioglass® 45S5 (BG) and BGLi were
synthesized by the sol-gel method. The remineralization tests were carried out
using in vitro demineralized enamel teeth and evaluated by Electron Microscopy
(SEM) and Vickers micro-hardness (HV). The antimicrobial behavior of the particles
was evaluated against S. mutans, A. actinomycetemcomitans, and P. gingivalis,
representing pathogens from caries and periodontitis. RESULTS: Enamel lesion was
partially remineralized when both bioglasses (BG and BGLi) were applied on its
surface with micro-hardness recoveries around 45 %. They further inhibited the
growth of S. mutans and P. gingivalis, at 50 and 200 mg/mL, respectively. BGLi
presented a higher toxicity against A. actinomycetemcomitans than BG, with
inhibition concentrations of 20 mg/mL and 100 mg/mL, respectively. CONCLUSIONS:
Bioglasses could be used in the treatment of two of the most prevalent oral
diseases: caries and periodontitis, promoting the remineralization of the teeth and
killing the main pathogens. The presence of Li did not affect the bioactivity of
the bioglass and improved the antibacterial effect over A. actinomycetemcomitans
strain.
AN - rayyan-563560025
AU - Palza Cordero, H.
AU - Castro Cid, R.
AU - Diaz Dosque, M.
AU - Cabello Ibacache, R.
AU - Palma Fluxá, P.
DO - 10.1016/j.jdent.2020.103575
KW - Bioglass
ion
ceramics
dental procedure
hardness
human
LA - English
PY - 2021
SN - 1879-176X
SP - 103575
ST - Li-doped bioglass® 45S5 for potential treatment of prevalent oral diseases
T2 - J Dent
TI - Li-doped bioglass® 45S5 for potential treatment of prevalent oral diseases
VL - 105
ID - 13399
ER -
TY - JOUR
AB - INTRODUCTION: Triclosan is a broad-spectrum antibacterial agent, marketed for
use in oral products. It is effective against both gram-positive and gram-negative
bacteria. PVM/MA is the non-proprietary designation for a polyvinylmethyl ether
maleic acid copolymer. It has been demonstrated that there is a greater uptake of
triclosan to enamel and buccal epithelial cells from the use of a fluoride
dentifrice containing triclosan and the PVM/MA copolymer than from a dentifrice
containing triclosan alone. This Supplement details the results of antibacterial,
anti-inflammatory, and short- and long-term plaque and gingivitis studies with a
triclosan/copolymer/ fluoride dentifrice. Additionally, the Supplement reviews
studies on the effect of a triclosan/copolymer/fluoride dentifrice on
periodontitis, calculus, caries, whitening and stain removal, oral malodor, and on
the microflora. CONCLUSION: Clinical studies indicate that the use of a
triclosan/copolymer/fluoride dentifrice (Colgate Total Toothpaste) may provide oral
health benefits beyond those associated with "traditional" toothpaste use, in a
manner that is safe and effective. Studies presented in this Supplement demonstrate
that Colgate Total Toothpaste provides superior protection against plaque and
gingivitis, caries, oral malodor, exhibits superior stain removal, and provides
protection against the progression of periodontal disease.
AN - rayyan-563561317
AU - Volpe, A. R.
AU - Petrone, M. E.
AU - DeVizio, W.
AU - Davies, R. M.
AU - Proskin, H. M.
J2 - J Clin Dent
KW - Anti-Infective Agents, Local/pharmacology/*therapeutic use
Anti-Inflammatory Agents, Non-Steroidal/pharmacology/*therapeutic use
Clinical Trials as Topic
Complex Mixtures/chemistry/pharmacology/therapeutic use
Dental Calculus/prevention & control
Dental Caries/prevention & control
Drug Combinations
Fluorides/chemistry/pharmacology/therapeutic use
Gingivitis/prevention & control
Halitosis/prevention & control
Humans
Maleates/pharmacology/*therapeutic use
Periodontitis/prevention & control
Polyethylenes/pharmacology/*therapeutic use
Silicic Acid
Tooth Discoloration/prevention & control
Toothpastes/chemistry/pharmacology/*therapeutic use
Triclosan/chemistry/pharmacology/therapeutic use
LA - eng
N1 - Colgate-Palmolive Technology Center Piscataway, NJ, USA.
PY - 2005
SN - 0895-8831 (Print)
SP - S1-19
ST - Advanced oral antibacterial/anti-inflammatory technology: A comprehensive
review of the clinical benefits of a triclosan/copolymer/fluoride dentifrice
TI - Advanced oral antibacterial/anti-inflammatory technology: A comprehensive
review of the clinical benefits of a triclosan/copolymer/fluoride dentifrice
VL - 16
ID - 14691
ER -
TY - JOUR
AB - Background: The present study formulates and evaluates a polyberry gel
comprising extracts of cranberry (Vaccinium macrocarpon) and brindle berry
(Garcinia cambogia) in patients suffering from chronic periodontitis. Materials and
Methods: The polyberry gel was evaluated for various physicochemical parameters, in
vitro permeability and stability, and the active phytoconstituents were quantified
by High-performance thin layer chromatography (HPTLC). Total phenolic content,
total antioxidants, and ascorbic acid were estimated in the two extracts by in
vitro assays. Patients suffering from chronic periodontitis with probing pocket
depth (PPD) up to 5 mm were divided into 3 groups of 21 patients each and treated
with scaling and root planing (SRP) or SRP followed by subgingival placement of
polyberry gel or tetracycline fibers (standard). Plaque Index (PI), Gingival Index
(GI), PPD, Clinical Attachment Level (CAL), and the salivary aspartate
aminotransferase (AST) and C-reactive protein (CRP) levels were recorded at
baseline and after 1 month. Results: A significant (P < 0.01) reduction in the
periodontic disease parameters was observed in the standard and gel-treated groups
between their baseline and 1-month time-interval readings. The polyberry gel
treatment significantly (P < 0.05 for AST and P < 0.01 for the rest) attenuated the
periodontitis-elevated PI, GI PPD, CAL, AST and CRP levels when compared with SRP
at the end of the study and was comparable with tetracycline. Conclusion: The
amelioration of periodontitis and gingival inflammation may be attributed to the
potent antioxidant activity of the polyphenolic phytoconstituents of the gel. The
polyberry gel may thus be used as a safe adjunct to SRP/tetracycline in chronic
periodontitis.
AN - rayyan-563559780
AU - Panda, V.
AU - Patidar, P.
AU - Gaikwad, R.
AU - Borade, S.
AU - Fernandes, L.
DO - 10.4103/jisp.jisp_393_22
IS - 4
KW - chemical analyzer
dental curette
dental needle
dental syringe
high performance liquid chromatograph
latex agglutination test kit
periodontal probe
tissue forceps
2,4 dinitrophenol
antioxidant
ascorbic acid
C reactive protein
cranberry extract
epinephrine
Garcinia cambogia extract
lidocaine
periodontal plus ab
phenol
quercetin
tetracycline
adult
article
berry
case control study
clinical evaluation
clinical outcome
comparative study
controlled study
cranberry
dental scaling
drug formulation
drug penetration
drug saliva level
drug stability
Garcinia cambogia
gingival index
high performance thin layer chromatography
human
in vitro study
physical chemistry
plaque index
prospective study
root planing
texture analysis
LA - English
PY - 2023
SN - ["0975-1580", "0972-124X"]
SP - 399-406
ST - Comparative clinical evaluation of a local drug delivery of cranberry and
garcinia fruit gel with tetracycline fibers for amelioration of periodontitis: A
split mouth study
TI - Comparative clinical evaluation of a local drug delivery of cranberry and
garcinia fruit gel with tetracycline fibers for amelioration of periodontitis: A
split mouth study
VL - 27
ID - 13154
ER -
TY - JOUR
AB - Periodontal disease comprises a group of inflammatory conditions of
periodontal tissues with common etiologic agent (bacteria) in the form of dental
plaque. The objective of this research was to prepare a water-in-oil type
microemulsion comprising metronidazole and equate its potency towards the effective
treatment of periodontitis. A pseudo ternary phase diagram for microemulsion
investigated using quaternary system containing water/captex 500/ tween 80/acconon
CC6. The microemulsion was preferred from the microemulsion area on the phase
diagram. Stable water-in-oil type metronidazole microemulsion was prepared
successfully using the quaternary system of water/captex 500/ tween 80/acconon CC6
at 4:1 ratio having droplet size in the range of 81 ± 12.91 to 196 ± 10.73 nm,
conductivity 50.6 ± 0.8 to 330.7 ± 1.1 μs/cm. In-vitro drug release, in vitro and
ex vivo antimicrobial activities by agar well diffusion were investigated.
Metronidazole Microemulsion loaded hydrogel formulations (F9 and F10) were found to
be optimized for maximum release and antimicrobial activity in terms of zone of
inhibition. The in vitro release evidenced that metronidazole microemulsion loaded
hydrogel release rate was maximum as compared to other plain metronidazole gels.
Stability study proved that microemulsion persisted stable for at least 6 months;
with no changes in clarity, characteristic properties, and no sign of
crystallization of metronidazole. In ex vivo evaluation, microemulsion based
hydrogels were effective against the microbial flora of the human oral cavity
suffering from periodontitis. The system was found to be appropriate for
application and more effective in reducing the clinical symptoms of periodontitis.
© 2014 The Korean Society of Pharmaceutical Sciences and Technology.
AN - rayyan-563560444
AU - Pandey, S.
AU - Das, U.
AU - Patil, A.
DO - 10.1007/s40005-014-0119-2
IS - 4
KW - cosurfactant
metronidazole
agar diffusion
article
color
conductance
controlled study
drug formulation
drug release
drug solubility
drug stability
flow kinetics
growth inhibition
human
hydrogel
microemulsion
nonhuman
periodontitis
pH
physical chemistry
priority journal
viscosity
LA - English
PY - 2014
SN - ["2093-6214", "2093-5552"]
SP - 225-236
ST - Formulation and ex-vivo evaluation of metronidazole microemulsion loaded
hydrogel for prevention of periodontitis
TI - Formulation and ex-vivo evaluation of metronidazole microemulsion loaded
hydrogel for prevention of periodontitis
VL - 44
ID - 13818
ER -
TY - JOUR
AB - Aims: Purification, identification and partial characterization of
bacteriocin produced by Lactobacillus paracasei HL32. It has been shown to have
activity against Porphyromonas sp. Methods and Results: The purification of
bacteriocin consisting of gel exclusion followed by anion exchange chromatography
produced a single band upon an electrophoresis gel with a molecular weight
corresponding to 56 kDa. The isolated protein contained 171 amino acids and the
first 151 were sequenced. The bacteriocin contained a high percentage of cationic
amino acids near the N-terminus, hydrophobic amino acids in the central region
(Leu, Ile, Val, Phe, Trp and Gly) and hydrophilic residues (Ser, Asn and Gln) at
the C-terminus. This structure did not match with that of previously reported
bacteriocins. The antimicrobial activity of the bacteriocin was determined against
some pathogens and normal microbiota (P. gingivalis, P. intermedia, T.
forsythensis, S. salivarius and S. sanguinis) found in saliva and crevicular fluid.
The bacteriocin was found to inhibit P. gingivalis at the minimum bactericidal
concentration (MBC) of 014 mmol l-1, but was found not to inhibit the other oral
micro-organisms. The bacteriocin was found from transmission electron microscopy
studies to cause pore formation in the cytoplasmic membranes of P. gingivalis at
the pole and induce potassium efflux. Bacteriocin concentrations of two to four
times of MBC were shown to induce haemolysis. The bacteriocin was heat-stable,
surviving at 110°C under pressure and possessed activity over a pH range of 68-85.
Only a small reduction of activity was found to occur after incubation in
biological fluids (saliva and crevicular fluid). Conclusions: A novel bacteriocin
has been identified that has selective activity against Porphyromonas sp.
associated with periodontal disease. Significance and Impact of the Study: The
findings of this work gained the knowledge of specific antibacterial activity of
bacteriocin against Porphyromonas gingivalis. © 2009 The Society for Applied
Microbiology.
AN - rayyan-563560685
AU - Pangsomboon, K.
AU - Bansal, S.
AU - Martin, G. P.
AU - Suntinanalert, P.
AU - Kaewnopparat, S.
AU - Srichana, T.
DO - 10.1111/j.1365-2672.2009.04146.x
IS - 6
KW - amino acid
asparagine
bacteriocin
cation
glutamine
glycine
isoleucine
leucine
metronidazole
phenylalanine
serine
tryptophan
valine
amino acid sequence
anion exchange chromatography
article
bacterial membrane
bacterial strain
carboxy terminal sequence
controlled study
drug activity
drug mechanism
drug purification
drug selectivity
gel electrophoresis
gingivitis
hemolysis
hydrophilicity
Lactobacillus paracasei
membrane channel
molecular weight
nonhuman
pathogenesis
periodontal disease
pH
Porphyromonas
potassium transport
protein isolation
saliva
thermostability
LA - English
PY - 2009
SN - ["1365-2672", "1364-5072"]
SP - 1928-1940
ST - Further characterization of a bacteriocin produced by Lactobacillus paracasei
HL32
TI - Further characterization of a bacteriocin produced by Lactobacillus paracasei
HL32
VL - 106
ID - 14059
ER -
TY - JOUR
AB - Porphyromonas gingivalis infections cause problems in periodontal diseases
and in certain systemic diseases. There is evidence that Lactobacillus spp. can
control populations of P. gingivalis, but there are few data on the effects of
purified bacteriocins from Lactobacillus paracasei HL32 on P. gingivalis. The
objective of this study was to examine the antibacterial activity of a bacteriocin
from L. paracasei HL32 and to relate this activity to its composition. A
bacteriocin was purified from culture supernatants of Lactobacillus spp. using a
dialysis technique followed by gel-permeation chromatography. Composition of the
bacteriocin was characterised by ninhydrin tests, ultraviolet spectrophotometry,
thin-layer chromatography, sodium-dodecyl sulphate-polyacrylamide gel
electrophoresis, electrospray ionisation mass spectrometry and amino acid analysis.
The amino acid sequence from the N-terminal of the bacteriocin was determined.
Antibacterial activity was examined by the cylinder plate method, microtitre assay
and scanning electron microscopy as compared with standard antibiotics. The
bacteriocin had a molecular weight of approximately 56 kDa, was comprised of 68%
carbohydrate and 32% protein, and showed maximum peak absorbance at 214 and 254 nm.
The bacteriocin was found to be effective against P. gingivalis; it caused swelling
and pore formation on the cell envelope at a minimum bactericidal concentration of
0.14 mM, and caused death within 2 h. Metronidazole killed P. gingivalis but did
not affect the envelope, whereas tetracycline affected P. gingivalis with cell
deformation. In conclusion, the bacteriocin from L. paracasei HL32 had the ability
to kill P. gingivalis, suggesting that it could be a promising alternative
chemotherapeutic agent for P. gingivalis infections. © 2006 Elsevier Ltd. All
rights reserved.
AN - rayyan-563560761
AU - Pangsomboon, K.
AU - Kaewnopparat, S.
AU - Pitakpornpreecha, T.
AU - Srichana, T.
DO - 10.1016/j.archoralbio.2006.03.008
IS - 9
bacteriocin
amino acid sequence
article
bacterial infection
Bacteroidaceae infection
cell wall
drug effect
genetics
Lactobacillus
metabolism
molecular genetics
molecular weight
periodontitis
ultrastructure
LA - English
PY - 2006
SN - 0003-9969
SP - 784-793
ST - Antibacterial activity of a bacteriocin from Lactobacillus paracasei HL32
against Porphyromonas gingivalis
TI - Antibacterial activity of a bacteriocin from Lactobacillus paracasei HL32
against Porphyromonas gingivalis
VL - 51
ID - 14135
ER -
TY - JOUR
AB - Purpose: To evaluate the effectiveness of Metronidazole (MTZ) and
Chlorhexidine (CHX) gels if used alone or in combination in the treatment of
periodontal inflammation Materials and Methods: A Randomized clinical trial, was
conducted at the Department of Periodontology, Liaquat University of Medical and
Health Sciences, in which patient having moderate to severe periodontitis, assessed
by using CPTIN community periodontal index, and bleeding index. Participants were
randomly allocated to one of the three groups, Group A -CHX gel Group B – MTZ gel
Group C - MTZ gel, and CHX gel both (MTZ –CHX). Furthermore, these indexes were
assessed at the 4th, 8th and 12th weeks, and questions were recorded for any
adverse effects. Data was analyzed using (SPSS) ANOVA– test used for comparison
within groups and finally Repeated measure ANOVA-test was used for intergroup
evaluation. Results: A significant improvement in the periodontal status and
bleeding index was observed in all treatment groups from the treatment groups when
compare baseline scores to all follow-up weeks, mean periodontal status of CHX
(baseline:2.7776, 4th week:1.2463, 8th week:2.230, 12th week 0.848) MTZ (baseline:
2.548, 4th week:1.7120, 8th week:1.988, 12th week:1.109) CHX+MTZ (baseline: 2.333,
4th week 1.2432, 8th week 1.482, 12th week:0.524 with p-value 0.0001, However
bleeding index showed significant results at the 12th week (CHX:0.825, MTZ:0.125,
CHX+MTZ:0.124) with the p-value 0.005 Conclusion: Adjunctive use of topical gels
showed significant improvements in clinical and numerical parameters in
periodontitis.
AN - rayyan-563559818
AU - Panhwar, M.
AU - Manzar, N.
AU - Bibi, B.
AU - Baloch, M. M.
AU - Ayub, T.
AU - Rehman, A.
DO - 10.53350/pjmhs22168504
IS - 8
chlorhexidine
metronidazole
adult
article
controlled study
disease severity
drug efficacy
female
follow up
human
male
monotherapy
periodontal index
periodontitis
SPSS
LA - English
PY - 2022
SN - 1996-7195
SP - 504-507
ST - Efficacy of Isolated and Combined Application of Topical Metronidazole and
Chlorhexidine in the Treatment of Periodontal Inflammation a Randomized Controlled
Trial
T2 - Pak. J. Med. Health Sci.
TI - Efficacy of Isolated and Combined Application of Topical Metronidazole and
Chlorhexidine in the Treatment of Periodontal Inflammation a Randomized Controlled
Trial
VL - 16
ID - 13192
ER -
TY - JOUR
AB - Objectives: The purpose of the present study was to compare the topical
application of chlorohexidine (CHX) and Metronidazole (MTZ) gels, individually and
in combination in patients with gingivitis for up to 12 weeks follow-up. Methods:
The clinical trial was conducted at Liaquat University of Medical Health Sciences
(LUMHS) Jamshoro and Hyderabad, Institute of Dentistry from 1st March 2019 to 1st
March 2020. Patients were selected based on inclusion criteria. Out of 125 screened
patients, ninety-nine patients agreed to participate in the study. At the beginning
of study all patients were assessed for gingival inflammation by using gingival
index (GI) (Loe and silness, 1963). Scaling root planning (SRP) was performed in
all patients. Subjects were randomly selected in three groups (n=33 each). In
Group-A CHX gel was applied, Group-B Metronidazole gel was applied and the
combination of two was applied to patients of Group-C. Patient follow up was done
and gingival parameters were assessed at baseline, fourth week and twelve weeks.
Apart from the clinical evaluation, a subjective evaluation was also undertaken.
Significance level of 0.05 and a desired study power of at least 80% was estimated.
Analysis of Variance (ANOVA) test for comparison was used within groups. Results: A
significant improvement in gingival scores was noted in all groups from baseline.
At 4 weeks CHX (1.25±0.21) MTZ (1.81±0.38) CHX+MTZ (1.29±0.34) compared to baseline
CHX (2.77±0.24) MTZ (2.84±0.54) CHX+MTZ (2.74±0.31) demonstrated substantial
improvement (p<0.001). However, gingival scores showed inclination at 12 weeks CHX
(1.18±0.41) MTZ (1.21±0.48) CHX+MTZ (1.11±0.14) with no significant difference to
week 4 (p>0.001). Conclusion: Local MTZ gel and MTZ+CHX gel showed effectiveness
similar to CHX gel application adjunct to scaling and root planning in the
treatment of gingivitis.
AN - rayyan-563559964
AU - Panhwar, M.
AU - Rajpar, S. P.
AU - Abrar, E.
AU - Alqutub, M.
AU - Abduljabbar, T.
DO - 10.12669/pjms.37.5.4236
IS - 5
KW - chlorhexidine
metronidazole
adult
article
clinical evaluation
clinical trial
dental scaling
drug efficacy
female
follow up
gingival index
gingivitis
human
male
questionnaire
root planing
tooth brushing
LA - English
PY - 2021
SN - 1682-024X
SP - 1425-1429
ST - Effectiveness of chlorhexidine and metronidazole gels in the management of
gingivitis. A clinical trial
T2 - Pak. J. Med. Sci.
TI - Effectiveness of chlorhexidine and metronidazole gels in the management of
gingivitis. A clinical trial
VL - 37
ID - 13338
ER -
TY - JOUR
AB - OBJECTIVE: To evaluate the effectiveness of a 0.5% chlorhexidine gel on the
reduction of interdental gingival bleeding. MATERIAL AND METHODS: Forty-three
mentally handicapped subjects, living in an institution (Casas André Luiz, Brazil),
were enrolled in a double-blind randomised clinical trial. The subjects were
randomly divided into two groups: test (chlorhexidine gel) and control (placebo
gel). The gel was applied with trays, twice a day, over a period of 8 weeks. The
interdental bleeding index (IBI) was recorded before and after the period in which
the gel was used. RESULTS: Statistical analysis showed that baseline IBI scores
were similar (p=0.82) for test and control groups (55.6% and 54.5%, respectively).
After 8 weeks, a statistically significant (p<0.001) decrease in IBI means took
place in the test group (33.2%). The control group presented a small increase
(60.6%) in IBI scores. The difference between groups was significant at the end of
the study (p<0.001). CONCLUSION: The results indicated that the use of a 0.5%
chlorhexidine gel was effective in reducing interdental gingival bleeding in
special patients.
AN - rayyan-563560883
AU - Pannuti, C. M.
AU - Saraiva, M. C.
AU - Ferraro, A.
AU - Falsi, D.
AU - Cai, S.
AU - Lotufo, R. F.
IS - 6
KW - chlorhexidine
adolescent
adult
article
Brazil
clinical trial
controlled study
dental procedure
female
gel
gingivitis
human
male
mental deficiency
periodontics
LA - English
PY - 2003
SN - 0303-6979
SP - 573-576
ST - Efficacy of a 0.5% chlorhexidine gel on the control of gingivitis in
Brazilian mentally handicapped patients
TI - Efficacy of a 0.5% chlorhexidine gel on the control of gingivitis in
Brazilian mentally handicapped patients
VL - 30
ID - 14257
ER -
TY - JOUR
AN - rayyan-563561986
AU - D'Ercole, S.
AU - Pilloni, A.
AU - D'Archivio, D.
AU - Lisanti, L.
AU - Graziani, F.
AU - Femminella, B.
AU - Sammartino, G.
AU - Perillo, L.
AU - Tete, S.
AU - Perfetti, G.
AU - Spoto, G.
AU - Piccolomini, R.
AU - Perinetti, G.
DO - 10.1902/jop.2009.090050
IS - 9
PY - 2009
SP - 1479-1492
ST - Clinical, Microbiologic, and biochemical effects of subgingival
administration of a xanthan-based chlorhexidine gel in the treatment of
periodontitis: A randomized multicenter trial
T2 - Journal of Periodontology
TI - Clinical, Microbiologic, and biochemical effects of subgingival
69949187998&doi=10.1902%2fjop.2009.090050&partnerID=40&md5=a0930a404aa2499aafdf7749
7ef715ed
VL - 80
ID - 15360
ER -
TY - JOUR
AB - Background: The use of locally delivered antibacterials containing
chlorhexidine (CHX) was proposed to improve the effectiveness of non-surgical
periodontal treatment. The present multicenter randomized study investigated the
effects of a xanthan-based chlorhexidine (Xan-CHX) gel used as an adjunct to
scaling and root planing (SRP) in the treatment of chronic periodontitis. Methods:
Ninety-eight systemically healthy subjects with moderate to advanced periodontitis
were recruited in four centers (59 females and 39 males; aged 24 to 58 years). For
each subject, two experimental sites located in two symmetric quadrants were chosen
with probing depths (PD) ≥5 mm and positive for bleeding on probing (BOP). These
two sites were randomized at the split-mouth level with one receiving a single SRP
treatment and the other receiving a single SRP + Xan-CHX gel treatment.
Supragingival plaque, modified gingival index, PD, clinical attachment level (CAL),
and BOP were evaluated at baseline (prior to any treatment) and after 3 and 6
months. At the same times, subgingival microbiologic samples and gingival
crevicular fluid (GCF) were collected for the analysis of total bacterial counts
(TBCs), including the identification of eight putative periodontopathogens, and
alkaline phosphatase (ALP) activity, respectively. Results: The Xan-CHX treatment
group showed greater improvements compared to the SRP group for PD andCAL at 3and
6months(P<0.001). The differences in PD reduction between the treatments were 0.87
and 0.83 mm at 3 and 6 months, respectively (P<0.001); for CAL, these were 0.94 and
0.90 mm, respectively (P <0.001). Similar behavior was seen when the subgroup of
pockets ≥7 mm was considered. The percentage of sites positive for BOP was similar
between the treatments at each time point. For the comparisons between the
treatment groups, no differences were seen in the TBCs and GCF ALP activity at
baseline and 6 months; in contrast, slightly, but significantly, lower scores were
recorded for the Xan-CHX treatment group at 3 months (P= 0.018 and P = 0.045,
respectively). Moreover, greater reductions in the percentages of sites positive
for the eight putative periodontopathic bacteria were generally seen for the Xan-
CHX treatment group compared to SRP alone. Conclusions: The adjunctive use of Xan-
CHX gel promoted greater PD reductions and CAL gains compared to SRP alone. These
results were concomitant with better microbiologic and biochemical outcomes when
Xan- CHX gel use was added to SRP, particularly up to 3 months after treatment.
AN - rayyan-563560668
AU - D'Ercolev, S.
AU - Pilloni, A.
AU - D'Archivio, D.
AU - Lisanti, L.
AU - Graziani, F.
AU - Femminella, B.
AU - Sammartino, G.
AU - Perillo, L.
AU - Tete, S.
AU - Perfetti, G.
AU - Spoto, G.
AU - Perinetti, G.
DO - 10.1902/jop.2009.090050
IS - 9
chlorhexidine
drug carrier
xanthan
adult
article
bacterial count
bacterium
chemistry
classification
clinical trial
comparative study
controlled study
female
follow up
gel
gingiva bleeding
gingivitis
human
male
microbiology
middle aged
multicenter study
periodontal disease
periodontal pocket
periodontics
tooth plaque
LA - English
PY - 2009
SN - 0022-3492
SP - 1479-1492
ST - Clinical, Microbiologic, and biochemical effects of subgingival
TI - Clinical, Microbiologic, and biochemical effects of subgingival
VL - 80
ID - 14042
ER -
TY - JOUR
AN - rayyan-563562063
AU - Perinetti, G.
AU - D'Ercole, S.
AU - Graziani, F.
AU - Catamo, G.
AU - Sammartino, G.
DO - 10.1902/jop.2008.070660
IS - 8
PY - 2008
SP - 1419-1425
ST - Internal decontamination of dental implants: An in vivo randomized
microbiologic 6-month trial on the effects of a chlorhexidine gel
TI - Internal decontamination of dental implants: An in vivo randomized
microbiologic 6-month trial on the effects of a chlorhexidine gel
49149092599&doi=10.1902%2fjop.2008.070660&partnerID=40&md5=6002063db68522261da67eb4
1c7fd49b
VL - 79
ID - 15437
ER -
TY - JOUR
AB - Nowadays, with the development of new and highly sensitive, blood is not the
only medium of choice for the diagnosis of several diseases and pathological
conditions. Saliva is now considered a safe and non-invasive sample to study oral
and systemic diseases, showing great diagnostic potential. According to several
recent studies, saliva has emerged as an emerging biofluid for the early diagnosis
of several diseases, indicated as a mirror of oral and systemic health and a
valuable source of clinically relevant information. Indeed, several studies have
observed that saliva is useful for detecting and diagnosing malignant tumours,
human immunodeficiency virus, heart disease, and autoimmune diseases. The growing
realisation that saliva is an inexhaustible source of information has led to the
coining of the term ‘Salivaomics’, which includes five “omics” in connection with
the main constituents of saliva: genome and epigenome, transcriptomics,
metabolomics, lipidomics, proteomics and microbiota. All those may be changed by
disease state, so they offer significant advantages in the early diagnosis and
prognosis of oral diseases. The aim of the present review isto update and highlight
the new frontiers of salivaomics in diagnosing and managing oral disorders, such as
periodontitis, premalignant disorders, and oral squamous cell carcinoma (OSCC).
AN - rayyan-563559827
AU - Papale, F.
AU - Santonocito, S.
AU - Polizzi, A.
AU - Giudice, A. L.
AU - Capodiferro, S.
AU - Favia, G.
AU - Isola, G.
DO - 10.3390/metabo12070638
IS - 7
KW - gamma interferon
glucocorticoid
interleukin 1
interleukin 17
interleukin 18
interleukin 6
interleukin 8
microRNA
microRNA 210
nitric oxide
RNA 16S
Actinomyces
autoimmune disease
cancer prognosis
Candida
capillary zone electrophoresis
Capnocytophaga gingivalis
confocal microscopy
dentist
dentistry
early diagnosis
electric field
epigenome
Fusobacteria
gene sequence
Haemophilus
heart disease
human
Human immunodeficiency virus
immune system
immunoregulation
intestine flora
leukoplakia
lipidomics
metabolome
metabolomics
microbiome
mouth cancer
mouth disease
Neisseria
nonhuman
omics
oral lichen planus
periodontal disease
periodontitis
prevalence
Prevotella
Prevotella melaninogenica
proteomics
radiography
review
saliva
Streptococcus mitis
systemic disease
transcriptomics
Veillonella
Western blotting
LA - English
PY - 2022
SN - 2218-1989
ST - The New Era of Salivaomics in Dentistry: Frontiers and Facts in the Early
Diagnosis and Prevention of Oral Diseases and Cancer
T2 - Metabolites
TI - The New Era of Salivaomics in Dentistry: Frontiers and Facts in the Early
Diagnosis and Prevention of Oral Diseases and Cancer
VL - 12
ID - 13201
ER -
TY - JOUR
AB - BACKGROUND: Currently, information available on the exact prevalence and
standard therapeutic protocol of peri-implant diseases is insufficient. The aim of
this survey was to investigate the perceived prevalence, etiology, and management
of peri-implant mucositis and peri-implantitis by periodontists in the United
States. METHODS: A twenty-question survey was developed. Periodontists currently
practicing in the United States were contacted by an e-mail that contained a link
to access the survey. RESULTS: Two hundred eighty periodontists (79.3% males; 62.9%
with >10 years in practice, 75.7% in private practice) completed the survey. Most
(96.1%) of the participants were placing implants (58.3% for >10 years and 32.4%
>150 implants/year). The majority reported that the prevalence of peri-implant
mucositis and peri-implantitis in their practices is up to 25% but is higher in the
general US population and that up to 10% of implants must be removed due to peri-
implantitis. There was agreement among contributing etiologic factors such as: 1)
plaque; 2) smoking; 3) adverse loading; 4) oral hygiene; 5) use of antimicrobial
gel/mouthrinse; 6) non-surgical debridement; 7) use of systemic antibiotics; and 8)
3-month supportive care for treatment of peri-implantitis. Significant
heterogeneity was recorded in relation to the instruments used for debridement, use
and type of surgical treatment, and materials used for regeneration. Only 5.1%
believed that treatment is very effective. CONCLUSIONS: This survey indicates that
peri-implant diseases are a frequently encountered problem in periodontal practices
and that the absence of a standard therapeutic protocol results in significant
empirical use of therapeutic modalities and a moderately effective treatment
outcome.
AN - rayyan-563560345
AU - Papathanasiou, E.
AU - Finkelman, M.
AU - Hanley, J.
AU - Parashis, A. O.
DO - 10.1902/jop.2015.150476
IS - 5
KW - clinical practice
dentist
female
human
male
mucosa inflammation
periimplantitis
prevalence
questionnaire
stomatitis
tooth implant
United States
LA - English
PY - 2016
SN - 1943-3670
SP - 493-501
ST - Prevalence, Etiology and Treatment of Peri-Implant Mucositis and Peri-
Implantitis: A Survey of Periodontists in the United States
TI - Prevalence, Etiology and Treatment of Peri-Implant Mucositis and Peri-
Implantitis: A Survey of Periodontists in the United States
VL - 87
ID - 13719
ER -
TY - JOUR
AB - AIM: The aim of this study was to evaluate the clinical and microbiologic
results of local delivery of adjunctive antimicrobials in the treatment and
management of patients with periodontitis. METHODS: The study population included
33 patients (age range, 37-49 years), with chronic adult periodontitis. Eleven of
33 received local treatment with 10% doxycycline injected directly into the
periodontal pocket; 11 received local treatment with a chlorhexidine-based gel
(1.5%) in situ; 11 received mechanical treatment with scaling and root planing. The
crevicular fluid of the doxycycline-treated group was analyzed using high
performance liquid chromatography over a period of 1 month. RESULTS: In the 11
patients treated with an antibiotic we observed a reduction in attachment loss and
a reduction in probing depth of 1.4 mm; in the 11 chlorhexidine-treated patients we
observed a reduction in attachment loss and a reduction in probing depth of 0.9 mm;
in the remaining 11 patients the reduction in attachment loss and probing depth was
less than those measured in the other two treatment groups. CONCLUSIONS: Our
results suggest that direct delivery of antimicrobial agents to the infection site
may be a useful adjunctive to conventional periodontal treatment.
AN - rayyan-563560757
AU - Pappalardo, S.
AU - Baglio, O. A.
AU - Cappello, C.
AU - Guarrera, S.
AU - De Benedittis, M.
AU - Petruzzi, M.
AU - Grassi, R. F.
IS - 11
chlorhexidine
doxycycline
adult
article
chronic disease
human
middle aged
periodontitis
LA - ["English", "Italian"]
PY - 2006
SN - 0026-4970
SP - 655-661
ST - Local delivery of antimicrobial drugs in the treatment of chronic adult
periodontitis
TI - Local delivery of antimicrobial drugs in the treatment of chronic adult
periodontitis
VL - 55
ID - 14131
ER -
TY - JOUR
AN - rayyan-563562126
AU - Paquette, D. W.
DO - 10.1111/j.1600-051X.1997.tb01834.x
IS - 4
PY - 1997
SP - 216-222
ST - Inhibition of experimental gingivitis in beagle dogs with topical salivary
histatins
TI - Inhibition of experimental gingivitis in beagle dogs with topical salivary
histatins
0031111737&doi=10.1111%2fj.1600-
051X.1997.tb01834.x&partnerID=40&md5=daa4d97661642833afe745b3285438cf
VL - 24
ID - 15500
ER -
TY - JOUR
AB - Locally delivered antimicrobials represent an expanding class of therapeutics
that may complement conventional mechanical treatments for chronic periodontitis.
Currently available locally delivered antimicrobials include a tetracycline fiber,
chlorhexidine chip, doxycycline gel, and newly approved minocycline microspheres.
This last therapeutic is formulated to contain 3 mg polyglycolide-co-dl lactide
(PGLA) copolymer and 1 mg of minocycline per unit (pocket) dose. As the polymer
microspheres resorb, minocycline is released locally within the periodontal pocket
at effective concentrations for at least 14 days. Recently, three phase 3 human
clinical trials were conducted to assess the efficacy and safety of minocycline
microspheres in patients with moderate-to-advanced chronic periodontitis. Data from
an open-label trial involving 173 subjects indicated that minocycline microspheres
plus scaling and root planing (SRP) at baseline produced significant improvements
in pocket depth (PD) (> or = 1.5 mm) at 1 and 3 months. Retreatment with
minocycline microspheres at 3 and 6 months maintained these improvements for 12
months. Two concurrent, blinded studies cumulatively recruited 748 periodontitis
subjects who were randomized to SRP plus minocycline microspheres, SRP plus vehicle
(placebo), or SRP alone at baseline. Minocycline microspheres or the vehicle were
readministered per the randomization at 3 and 6 months. Patients receiving
minocycline microspheres plus SRP exhibited significantly greater PD reduction at
1, 3, 6, and 9 months compared to patients receiving SRP plus vehicle or SRP alone.
Overall, mean PD reduction with adjunctive minocycline-microsphere treatment
increased when patients with more advanced periodontitis (mean PD > or = 6 mm or 7
mm) were considered. Similarly, significant improvements in clinical attachment
level and percent bleeding on probing were observed among advanced periodontitis
patients treated with SRP plus minocycline microspheres relative to controls.
Patients treated with minocycline microspheres plus SRP were 50% more likely to
shift to an overall mean PD < 5 mm or to a more maintainable case definition. No
increased incidence of adverse events or tetracycline resistance were observed with
minocycline-microsphere treatment. The data from these clinical trials indicate
that minocycline microspheres plus SRP are safe in patients and more effective than
SRP alone in reducting the signs of chronic periodontitis.
AN - rayyan-563560908
IS - 5
drug carrier
lactic acid
microsphere
minocycline
placebo
polyglycolic acid
polyglactin
polymer
article
chronic disease
clinical trial
comparative study
controlled study
female
follow up
gingiva bleeding
human
male
middle aged
periodontal disease
periodontitis
safety
treatment outcome
LA - English
PY - 2002
SN - 1548-8578
SP - 15-21
ST - Minocycline microspheres: a complementary medical-mechanical model for the
TI - Minocycline microspheres: a complementary medical-mechanical model for the
VL - 23
ID - 14282
ER -
TY - JOUR
AN - rayyan-563561940
AU - Levine, W. Z.
IS - 6
PY - 2015
SP - e12-e14
ST - Adjunctive Treatment of Periodontal Disease with Self-Adhesive Hydrogel Wound
Dressing: Case Series
T2 - Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
TI - Adjunctive Treatment of Periodontal Disease with Self-Adhesive Hydrogel Wound
Dressing: Case Series
85015140119&partnerID=40&md5=4e0b7b29df038eb6a1d61f9350d27f7e
VL - 36
ID - 15314
ER -
TY - JOUR
AB - BACKGROUND: Our research group has recently reported that exogenously applied
histatins can inhibit plaque accumulation and gingival inflammation in a
preclinical canine model (Paquette et al. 1997). OBJECTIVES: The aims of the
present double-blinded, randomized, controlled clinical trial were to evaluate the
safety and toxicity of three histatin (P-113) concentrations in gel formulations,
and to assess potential clinical benefit on the development of gingivitis (partial
mouth design). MATERIAL AND METHODS: One hundred and six healthy subjects were
recruited and brought to optimal gingival health (GI < 0.5) prior to treatment
initiation. At baseline, eligible subjects were randomized for one of the following
treatments: (1) placebo; (2) 0.0625% P-113; (3) 0.125% P-113; and (4) 0.375% P-113.
Patients self-applied gels twice daily for 29 days to the maxillary right quadrant
with the use of customized stents. In addition, patients deferred all oral hygiene
procedures within this quadrant for the duration of the treatment period. Safety
was assessed in terms of physical and oral examinations, clinical laboratory
testing and recording of adverse events. Clinical indices were measured weekly and
included gingival index (GI), plaque index (PI) and %BOP. RESULTS: All study
formulations were well tolerated by patients, and no differences in adverse event
occurrences were noted among treatment groups, including taste alteration or
staining. For the intent-to-treat population, significantly smaller %BOP changes
were noted in subjects treated with 0.0625, 0.125 and 0.375% P-113 gels (17.4,
18.18 and 17.9%, respectively) versus placebo (28.0%) (p < 0.05) at day 29. When
groups were compared in terms of per cent responders (change in %BOP < 15 or <
20%), P-113 treatment groups exhibited a higher frequency of response, especially
for the 0.0625 and 0.125% P-113 formulations (p < 0.05). Although no statistically
significant intergroup differences were noted for changes in GI or PI among all
subjects (intent-to-treat population), significantly smaller changes in PI at day
22 were observed among compliant individuals (defined as subjects using > 60% of
the target gel mass) administering P-113 gels as compared with compliant placebo
subjects (p < 0.05). CONCLUSIONS: These data indicate safety and tolerance of P-113
gels for topical oral use in human subjects. These data also suggest that P-113
gels administered twice daily may reduce experimental gingivitis as measured with
bleeding on probing in humans.
AN - rayyan-563560893
AU - Simpson, D. M.
AU - Friden, P.
AU - Braman, V.
IS - 12
histidine rich proteins
protein
saliva protein
adult
article
clinical trial
controlled study
drug tolerance
female
gel
gingivitis
human
male
nonparametric test
periodontics
safety
tooth plaque
treatment outcome
LA - English
PY - 2002
SN - 0303-6979
SP - 1051-1058
ST - Safety and clinical effects of topical histatin gels in humans with
experimental gingivitis
TI - Safety and clinical effects of topical histatin gels in humans with
experimental gingivitis
VL - 29
ID - 14267
ER -
TY - JOUR
AB - Histatins, histidine-rich proteins found within parotid and submandibular
secretions, are a novel class of endogenous peptides with antimicrobial properties.
This masked, randomized, placebo-controlled preclinical investigation examined the
effect of 3 topical histatins on the development of plaque and gingivitis in beagle
dogs. 16, female, 1-year-old beagles were brought to optimal gingival health by
mechanical scaling and polishing followed by rigorous daily tooth brushing. At the
conclusion of this pretreatment period, dogs were randomly divided into 4 groups
for the application of test formulations, and were placed on a plaque-promoting
diet. Test agents included 3 synthetic salivary histatins (histatin 5, P-113 and P-
113D) which were incorporated in hydroxypropyl methylcellulose gel at a
concentration of 0.125%, and a placebo, or negative control, which was the gel
vehicle alone. Throughout the 10-week treatment period, test formulations (2.0 ml)
were applied 2 x daily to all premolar teeth using a Monojet syringe. Plaque
formation and gingival inflammation were assessed using the plaque (PI) and
gingival (GI) indices on days 0, 7, 14, 21, 28, 42, 56 and 70. Furthermore,
bleeding to probing was recorded as a percent of sites (%BOP) and according to the
modified sulcus bleeding index (mSBI). Comparisons among groups and between group
pairs (active versus placebo) were made with Kruskal-Wallis tests with the average
of data over the interval, days 14-42, being the primary focus of the analysis.
From baseline to day 7, all groups expressed similar indices. Thereafter, overall
significant differences among the groups were noted at day 42 for PI, at days 21,
28, 42 and 70 for GI, and at days 14 and 28 for %BOP (p < 0.05). In particular,
beagles treated with P-113 demonstrated significantly lower PI scores at day 42 (p
< 0.05), significantly lower GI scores from days 21 through 42 (p < 0.05), and
significantly lower %BOP scores at days 14 and 28 (p < 0.05) compared to beagles
treated with placebo. Beagles treated with P-113D exhibited significantly lower GI
at day 42 compared to the placebo (p < 0.05). For the primary analysis conducted
over the midtreatment interval (days 14-42), significant differences were detected
for all parameters except mSBI (p < 0.05). Accordingly, significantly lower PI
scores were found for P-113, lower GI scores for P-113 and P-113D, and lower %BOP
for P-113 and P-113D compared to placebo (p < 0.05). These data indicate that in
the beagle model, salivary histatins, P-113 and P-113D, topically applied, can
significantly reduce clinical signs of plaque formation and gingival inflammation.
AN - rayyan-563561046
AU - Waters, G. S.
AU - Stefanidou, V. L.
AU - Lawrence, H. P.
AU - Friden, P. M.
AU - O'Connor, S. M.
AU - Sperati, J. D.
AU - Hutchens, L. H.
IS - 4
KW - histidine rich proteins
protein
saliva protein
animal
article
dog
drug screening
female
gingivitis
nonparametric test
periodontics
randomization
tooth plaque
LA - English
PY - 1997
SN - 0303-6979
SP - 216-222
ST - Inhibition of experimental gingivitis in beagle dogs with topical salivary
histatins
TI - Inhibition of experimental gingivitis in beagle dogs with topical salivary
histatins
VL - 24
ID - 14420
ER -
TY - JOUR
AB - beta-Glucan can provide excellent environment to apply to drug carrier due to
its immunological and anti-inflammatory effect. Minocycline hydrochloride (MH) has
excellent oral bioavailability pharmacological properties. Specifically, MH is
effectively absorbed into the gingiva for periodontal disease treatment. In this
study, we attempt to develop MH loaded beta-glucan hydrogel for periodontal disease
treatment through radiation-crosslinking technique. In addition, MH loaded beta-
glucan hydrogels were tested for their cytotoxicity and antibacterial activity.
Finally, we conducted an in vivo study to demonstrate the potential to prevent the
invasion of bacteria to treat periodontal disease. The gel content and compressive
strength of the beta-glucan hydrogels increased as the beta-glucan content and the
absorbed dose (up to 7 kGy) increased. For a radiation dose of 7 kGy, the gelation
and the compressive strength of a 6 wt% beta-glucan hydrogel were approximately 92%
and 270 kPa, respectively. As a drug, MH was consistently released from beta-glucan
hydrogels, reaching 80% at approximately 90 min. Furthermore, the MH loaded beta-
glucan hydrogels showed no cytotoxicity. The MH loaded beta-glucan hydrogels
exhibited good antibacterial activity against Porphyromonas gingivalis. In
addition, MH loaded beta-glucan hydrogel demonstrated the potential of a good
capability to prevent the invasion of bacteria and to treat wounds. (C) 2018
Published by Elsevier B.V.
AN - rayyan-563562304
AU - Park, J. S.
AU - Lim, Y. M.
AU - Baik, J.
AU - Jeong, J. O.
AU - An, S. J.
AU - Jeong, S. I.
AU - Gwon, H. J.
AU - Khil, M. S.
DO - 10.1016/j.ijbiomac.2018.06.068
PY - 2018
SN - ["0141-8130", "1879-0003"]
SP - 333-339
ST - Preparation and evaluation of beta-glucan hydrogel prepared by the radiation
technique for drug carrier applications
TI - Preparation and evaluation of beta-glucan hydrogel prepared by the radiation
VL - 118
Y2 - 10 y3 - 15
ID - 15678
ER -
TY - JOUR
AB - β-Glucan can provide excellent environment to apply to drug carrier due to
its immunological and anti-inflammatory effect. Minocycline hydrochloride (MH) has
excellent oral bioavailability pharmacological properties. Specifically, MH is
effectively absorbed into the gingiva for periodontal disease treatment. In this
study, we attempt to develop MH loaded β-glucan hydrogel for periodontal disease
treatment through radiation-crosslinking technique. In addition, MH loaded β-glucan
hydrogels were tested for their cytotoxicity and antibacterial activity. Finally,
we conducted an in vivo study to demonstrate the potential to prevent the invasion
of bacteria to treat periodontal disease. The gel content and compressive strength
of the β-glucan hydrogels increased as the β-glucan content and the absorbed dose
(up to 7 kGy) increased. For a radiation dose of 7 kGy, the gelation and the
compressive strength of a 6 wt% β-glucan hydrogel were approximately 92% and 270
kPa, respectively. As a drug, MH was consistently released from β-glucan hydrogels,
reaching 80% at approximately 90 min. Furthermore, the MH loaded β-glucan hydrogels
showed no cytotoxicity. The MH loaded β-glucan hydrogels exhibited good
antibacterial activity against Porphyromonas gingivalis. In addition, MH loaded β-
glucan hydrogel demonstrated the potential of a good capability to prevent the
invasion of bacteria and to treat wounds.
AN - rayyan-563560234
AU - Park, J. S.
AU - Lim, Y. M.
AU - Baik, J.
AU - Jeong, J. O.
AU - An, S. J.
AU - Jeong, S. I.
AU - Gwon, H. J.
AU - Khil, M. S.
DO - 10.1016/j.ijbiomac.2018.06.068
KW - beta glucan
drug carrier
minocycline
adult
animal cell
animal experiment
animal model
article
cell viability
cross linking
drug cytotoxicity
drug release
drug synthesis
hydrogel
in vivo study
male
mouse
nonhuman
periodontal disease
radiation dose
rat
species invasion
LA - English
PY - 2018
SN - ["1879-0003", "0141-8130"]
SP - 333-339
ST - Preparation and evaluation of β-glucan hydrogel prepared by the radiation
TI - Preparation and evaluation of β-glucan hydrogel prepared by the radiation
VL - 118
ID - 13608
ER -
TY - JOUR
AB - Ginger (Zingiber officinale Roscoe) has been used widely as a food spice and
an herbal medicine. In particular, its gingerol-related components have been
reported to possess antimicrobial and antifungal properties, as well as several
pharmaceutical properties. However, the effective ginger constituents that inhibit
the growth of oral bacteria associated with periodontitis in the human oral cavity
have not been elucidated. This study revealed that the ethanol and n-hexane
extracts of ginger exhibited antibacterial activities against three anaerobic Gram-
negative bacteria, Porphyromonas gingivalis ATCC 53978, Porphyromonas endodontalis
ATCC 35406 and Prevotella intermedia ATCC 25611, causing periodontal diseases.
Thereafter, five ginger constituents were isolated by a preparative high-
performance liquid chromatographic method from the active silica-gel column
chromatography fractions, elucidated their structures by nuclear magnetic resonance
spectroscopy and electrospray ionization mass spectrometry and their antibacterial
activity evaluated. In conclusion, two highly alkylated gingerols, [10]-gingerol
and [12]-gingerol effectively inhibited the growth of these oral pathogens at a
minimum inhibitory concentration (MIC) range of 6-30 μg/mL. These ginger compounds
also killed the oral pathogens at a minimum bactericidal concentration (MBC) range
of 4-20 μg/mL, but not the other ginger compounds 5-acetoxy-[6]-gingerol, 3, 5-
diacetoxy-[6]-gingerdiol and galanolactone. Copyright © 2008 John Wiley & Sons,
Ltd.
AN - rayyan-563560695
AU - Park, M.
AU - Bae, J.
AU - Lee, D. S.
DO - 10.1002/ptr.2473
IS - 11
KW - (10) gingerol
12 gingerol
gingerol
unclassified drug
anaerobic bacterium
article
drug isolation
drug structure
ginger
mouth flora
nonhuman
periodontitis
rhizome
LA - English
PY - 2008
SN - ["0951-418X", "1099-1573"]
SP - 1446-1449
ST - Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from
ginger rhizome against periodontal bacteria
TI - Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from
ginger rhizome against periodontal bacteria
VL - 22
ID - 14069
ER -
TY - JOUR
AB - BACKGROUND: We found that the edible green seaweed Enteromorpha linza
displayed potent antimicrobial activity against Prevotella intermedia and
Porphyromonas gingivalis. To elucidate the active component of E. linza, isolation
procedures were performed. RESULTS: The main active compound was isolated by
polarity fractionation, Sephadex LH-20 gel chromatography, and reverse-phase high-
performance liquid chromatography (RP-HPLC). The active compounds were eluted at
isocratic 95% acetonitrile by RP-HPLC and identified as unsaturated fatty acids,
stearidonic acid (SA, C18:4 n-3) and gamma-linolenic acid (GLA, C18:3 n-6) by gas
chromatography-mass spectrometry, (1)H nuclear magnetic resonance (NMR)
spectroscopy, and (13)C NMR spectroscopy. The yields of SA and GLA from dried
seaweed tissue were 6.33 × 10(-3)% and 6.47 × 10(-3)%, respectively. The minimal
inhibitory concentration values of SA and GLA were 39.06 μg/mL against P.
intermedia and 9.76 μg/mL against P. gingivalis, respectively. SA and GLA were also
active against several other oral pathogens, including Aggregatibacter
actinomycetemcomitans, Candida albicans, Fusobacterium nucleatum subsp. vincenti,
and Streptococcus mutans, at micromolar concentrations. CONCLUSIONS: These data
suggest that the E. linza extracts SA and GLA are useful antimicrobial agents for
the prevention and/or treatment of periodontitis.
AN - rayyan-563561252
AU - Park, N. H.
AU - Choi, J. S.
AU - Hwang, S. Y.
AU - Kim, Y. C.
AU - Hong, Y. K.
AU - Cho, K. K.
AU - Choi, I. S.
DO - 10.1186/1999-3110-54-39
IS - 1
J2 - Bot Stud
LA - eng
N1 - Gijang Local Products Co. Ltd, Ilgwang-myeon, Gijang-gun, Busan, 619-911,
Republic of Korea.; RIS Center, IACF, Silla University, Sasang-gu, Busan, 617-736,
Republic of Korea.; Gijang Local Products Co. Ltd, Ilgwang-myeon, Gijang-gun,
Busan, 619-911, Republic of Korea.; Gijang Local Products Co. Ltd, Ilgwang-myeon,
Gijang-gun, Busan, 619-911, Republic of Korea.; Department of Biotechnology,
Pukyong National University, Nam-gu, Busan, 608-737, Republic of Korea.; Department
of Animal Resources Technology, Gyeongnam National University of Science and
Technology, Jinju, Gyeongnam, 660-758, Republic of Korea.; RIS Center, IACF, Silla
University, Sasang-gu, Busan, 617-736, Republic of Korea. ischoi@silla.ac.kr.;
Depertment of Biological Science, Silla University, Sasang-gu, Busan, 617-736,
Republic of Korea. ischoi@silla.ac.kr.
PY - 2013
SN - 1817-406X (Print)
SP - 39
ST - Antimicrobial activities of stearidonic and gamma-linolenic acids from the
green seaweed Enteromorpha linza against several oral pathogenic bacteria
T2 - Botanical studies
TI - Antimicrobial activities of stearidonic and gamma-linolenic acids from the
green seaweed Enteromorpha linza against several oral pathogenic bacteria
VL - 54
Y2 - 12
ID - 14626
ER -
TY - JOUR
AB - Saliva is a complex multifunctional fluid that bathes the oral cavity to
assist in soft and hard tissue maintenance, lubrication, buffering, defense against
microbes, and initiating digestion of foods. It has been extensively characterized
in humans but its protein composition in dogs remains poorly characterized, yet
saliva composition could explain (patho) physiological differences between
individuals, breeds and with humans. This pilot discovery study aimed to
characterize canine saliva from two breeds, Labrador retrievers and Beagles, and to
compare this with human saliva using quantitative mass spectrometry. The analysis
demonstrated considerable inter-individual variation and difference between breeds;
however these were small in comparison to the differences between species.
Functional mapping suggested roles of detected proteins similar to those found in
human saliva with the exception of the initiation of digestion as salivary amylase
was lacking or at very low abundance in canine saliva samples. Many potential anti-
microbial proteins were detected agreeing with the notion that the oral cavity is
under continuous microbial challenge.
AN - rayyan-563560266
AU - Pasha, S.
AU - Inui, T.
AU - Chapple, I.
AU - Harris, S.
AU - Holcombe, L.
AU - Grant, M. M.
DO - 10.1002/pmic.201700293
IS - 3
KW - alpha amylase saliva isoenzyme
mucin 7
proteome
saliva protein
adult
article
beagle
female
gel electrophoresis
human
Labrador retriever
male
nonhuman
priority journal
protein analysis
saliva
LA - English
PY - 2018
SN - ["1615-9861", "1615-9853"]
ST - The Saliva Proteome of Dogs: Variations Within and Between Breeds and Between
Species
T2 - Proteomics
TI - The Saliva Proteome of Dogs: Variations Within and Between Breeds and Between
Species
VL - 18
ID - 13640
ER -
TY - JOUR
AB - This work evaluates whether isolation and toxicity of subgingival
Staphylococcus aureus strains correlate with progression of periodontal lesions and
whether isolates are characterized by a specific genomic background. The study
involved 165 subjects affected by generalized aggressive periodontitis. Three sets
of samples of supragingival and subgingival plaque were obtained at 45-day
intervals from active and non-active sites, to detect S. aureus. Susceptibility to
antibiotics, the presence of 17 genes, genomic restriction profiles and multilocus
sequence typing (MLST) were performed to characterize all isolates. S. aureus was
detected in 37.6% of the subjects. Subgingival colonization rates were 66.1% and
12.9% for active and non-active sites, respectively (P<0.01). Supragingival and
subgingival isolates were shown to be distinct by molecular genotyping and DNA
fingerprint analysis. MLST showed that isolates were not genetically related and no
sequence type was predominant in any of the two locations. These data demonstrate
that S. aureus is associated with the progression of aggressive periodontitis and
that a specific set of characters is necessary for the bacterium to colonize
subgingival sites. Comparative analysis of genomic structure and genetic-related
data suggest that the periodontal environment could promote genetic evolution of
strains. Copyright © by BIOLIFE, s.a.s.
AN - rayyan-563560566
AU - Passariello, C.
AU - Lucchese, A.
AU - Virga, A.
AU - Pera, F.
AU - Gigola, P.
DO - 10.1177/1721727X1201000326
IS - 3
KW - bacterial DNA
ciprofloxacin
clindamycin
erythromycin
fosfomycin
genomic DNA
gentamicin
levofloxacin
nitrofurantoin
norfloxacin
oxacillin
mupirocin
rifamycin
tetracycline
tobramycin
adult
article
bacterial genome
bacterial strain
bacterial virulence
bacterium isolation
comparative genomic hybridization
controlled study
disease course
DNA fingerprinting
female
genetic variability
genotype
gingiva
human
male
molecular evolution
multilocus sequence typing
nonhuman
periodontitis
periodontium
LA - English
PY - 2012
SN - 1721-727X
SP - 501-513
ST - Isolation of Staphylococcus aureus and progression of periodontal lesions in
T2 - Eur. J. Inflamm.
TI - Isolation of Staphylococcus aureus and progression of periodontal lesions in
VL - 10
ID - 13940
ER -
TY - JOUR
AB - Periodontitis is a locally limited disease caused by bacteria. The local
application presents itself useful for the indicated medicamentous therapy of
periodontitis by means of metronidazole. In preliminary tests the metronidazole
liberation from hollow fibres, in gel and from polyvinyl alcohol platelets has been
tested by ultraviolet absorption measurement. The hollow fibres have been evaluated
no more because of too small agent absorption in the clinical test. In polyvinyl
alcohol metronidazole acts definitely over 3 days. However, the prolonged action in
the gel form is not definitely (45 min to 24 h). A single one or repeated twice
metronidazole/polyvinyl alcohol platelet application results in a sufficient long
and high metronidazole concentration in the gingival pocket.
AN - rayyan-563561174
AU - Pässler, R.
AU - Nossek, H.
IS - 1
KW - metronidazole
polyvinyl alcohol
article
comparative study
drug screening
gel
gingiva
gingivitis
human
in vitro study
metabolism
time
LA - German
PY - 1989
SN - 0303-6464
SP - 12-16
ST - The concentration and duration of the action of metronidazole in the gingival
pocket following local application
T2 - Untersuchungen zur Konzentration und Wirkungsdauer von Metronidazol in der
Zahnfleischtasche nach lokaler Applikation.
TI - The concentration and duration of the action of metronidazole in the gingival
pocket following local application
VL - 77
ID - 14548
ER -
TY - JOUR
AB - Hydrogels are cross-linked hydrophilic polymer structures that imbibe large
quantities of water or biological fluids. Hydrogels are an upcoming class of
polymer-based controlled release drug delivery systems, embracing numerous
biomedical and pharmaceutical applications. Hydrogels are swellable polymeric
materials, and are being widely investigated as a carrier for drug delivery
systems. Besides exhibiting swelling-controlled drug release, hydrogels also show
stimuli responsive changes in their structural network and hence leading to the
drug release. The present manuscript is concerned with the classification, method
of preparation; application in drug deliveryand FDA approved market products of
hydrogels with the patent review on hydrogel composition and its manufacturing
process. It also highlights recent advances in hydrogel drug delivery especially
stimuli-responsive hydrogel and its patents. This patent review is useful in the
synthesis methods of hydrogel drug delivery and its application. © 2013 Bentham
Science Publishers.
AN - rayyan-563560461
AU - Patel, G. C.
AU - Dalwadi, C. A.
IS - 3
KW - agarose
alginic acid
biomaterial
bupivacaine
carrageenan
cellulose
chitosan
chondroitin sulfate
collagen
dextran
doxycycline
doxycycline hyclate
fibrin
hyaluronic acid
leuprorelin
macrogol
octreotide
paclitaxel
pectin
poly(n isopropylacrylamide)
polyacrylic acid
polycaprolactone
polylactic acid
polylysine
polymer
polyvinyl alcohol
prostaglandin E2
pullulan
risperidone
timolol
timolol maleate
unclassified drug
unindexed drug
acromegaly
bipolar disorder
classification
coacervation
cross linking
freeze thawing
glaucoma
human
hydrogel
hydrogen bond
patent
periodontal disease
pH
physical chemistry
polymer production
polymerization
postoperative pain
priority journal
prostate cancer
radiation cross linking
review
schizophrenia
temperature
ultrasound
viscoelasticity
atridox
cervidil
eligard
lupron depot
oncogel
POSIDUR
Relday
sandostatin
timoptic xe
LA - English
PY - 2013
SN - 1872-2113
SP - 206-215
ST - Recent patents on stimuli responsive hydrogel drug delivery system
TI - Recent patents on stimuli responsive hydrogel drug delivery system
VL - 7
ID - 13835
ER -
TY - JOUR
AB - Tinidazole is well reported for the treatment of periodontal disease, they
have better penetration into periodontal tissues, minimal bacterial resistance as
compared to many of the other drugs used for the treatment. In situ gel-forming
systems are viscous liquids that shift to a gel phase upon exposure to
physiological conditions. Tinidazole periodontal gel was prepared by different
concentrations of gellan gum, poloxamer 407. 32full factorial design was applied
for optimization. Selected dependent variables were concentration of gellan gum
(X1) and poloxamer 407 (X2). Selected independent variables were viscosity (Y1)
release at 1 hour (Y2), release at 8 hour (Y3). All the prepared formulations were
evaluated for appearance, pH, viscosity, % drug content, syringeability, % drug
release and effect of sterilization. By compatibility study drug was found to be
compatible with formulation excipients. Gelation temperature and pH of all
formulation found to be in the range of 29-40ºC and 5.34-6.83 respectively.
Viscosity of all prepared formulations was found in the range of 310- 692
centipoise. Both the independent variable had the significant effect on the entire
three response variable (P& 0.05). All the formulations were developed using
combination of gellan gum and poloxamer 407. The developed formulations showed
satisfactory results for in-vitro gelling capacity, rheology and other physical
properties. Based on maximum desirability and cost effectiveness formulation
containing 0.5%w/v of gellan gum and 15 %w/v of poloxamer 407 was consider as an
optimized batch.
AN - rayyan-563560455
AU - Patel, K. S.
AU - Vadalia, K. R.
AU - Patel, J. K.
IS - 7
KW - citrate sodium
gellan
methyl paraben
poloxamer
propyl paraben
tinidazole
article
bioavailability
drug formulation
drug interaction
drug release
drug sterility
factorial design
flow kinetics
gel
gelation
melting point
periodontitis
pH
preformulation
viscosity
LA - English
PY - 2014
SN - ["0974-4304", "0974-4304"]
SP - 2102-2112
ST - Development and evaluation of in situ gelling system for treatment of
periodontitis
TI - Development and evaluation of in situ gelling system for treatment of
periodontitis
VL - 6
ID - 13829
ER -
TY - JOUR
AB - Peroral administration of drugs, although most preferred by both clinicians
and patients has several disadvantages such as hepatic first pass metabolism and
enzymatic degradation within the GI tract, that prohibit oral administration of
certain classes of drugs especially peptides and proteins. Consequently, other
absorptive mucosae are considered as potential sites for administration of these
drugs. Among the various transmucosal routes studied the buccal mucosa offers
several advantages for controlled drug delivery for extended period of time. The
mucosa is well supplied with both vascular and lymphatic drainage and first-pass
metabolism in the liver and pre-systemic elimination in the gastrointestinal tract
is avoided. The area is well suited for a retentive device and appears to be
acceptable to the patient. With the right dosage form, design and formulation, the
permeability and the local environment of the mucosa can be controlled and
manipulated in order to accommodate drug permeation. Buccal drug delivery is thus a
promising area for continued research with the aim of systemic and local delivery
of orally inefficient drugs as well as feasible and attractive alternative for non-
invasive delivery of potent protein and peptide drug molecules. Extensive review
pertaining specifically to the patents relating to buccal drug delivery is
currently available. However, many patents e.g. US patents 6, 585,997;
US20030059376A1 etc. have been mentioned in few articles. It is the objective of
this article to extensively review buccal drug delivery by discussing the recent
patents available. Buccal dosage forms will also be reviewed with an emphasis on
bioadhesive polymeric based delivery systems. © 2008 Bentham Science Publishers
Ltd.
AN - rayyan-563560704
AU - Pathan, S. A.
AU - Iqbal, Z.
AU - Sahani, J. K.
AU - Talegaonkar, S.
AU - Khar, R. K.
AU - Ahmad, F. J.
DO - 10.2174/187221108784534135
IS - 2
KW - acrylic acid
buprenorphine
carbomer
carrageenan
copolymer
cyclodextrin derivative
drug carrier
estradiol
glyceryl trinitrate
gonadorelin
hydralazine
isosorbide dinitrate
karaya gum
lidocaine
macrogol
miconazole
nanoparticle
nimesulide
polyacrylic acid
polylactic acid
polymer
propranolol
retinol
surfactant
unindexed drug
verapamil
xanthan
acidity
aphthous stomatitis
aqueous solution
biodegradability
buccal mucosa
colloid
drug absorption
drug blood level
drug degradation
drug design
drug effect
drug efficacy
drug formulation
drug metabolism
drug potency
drug release
drug safety
drug solubility
drug stability
first pass effect
gingivitis
human
hydrogel
hydrophobicity
lozenge
mouth hygiene
mouth injury
mouth ulcer
mouthwash
nonhuman
osteoporosis
patent
patient compliance
priority journal
review
systemic disease
tablet formulation
treatment duration
LA - English
PY - 2008
SN - 1872-2113
SP - 177-188
ST - Buccoadhensive drug delivery systems - Extensive review on recent patents
TI - Buccoadhensive drug delivery systems - Extensive review on recent patents
VL - 2
ID - 14078
ER -
TY - JOUR
AB - Background: Peri-implant infections are associated with the establishment and
maturation of a bacterial biofilm characterized by a predominance of Gram-negative
fusiform anaerobic species. The decontamination of implant surfaces is then crucial
for a successful peri-implant therapy. Methods: Twenty-one smooth and 21 rough
implants, divided into four groups according to surface and treatment modality,
were contaminated with Streptococcus sanguinis and then placed in an incubator with
the atmosphere of 5% CO2 at 37 degrees C for 24 hours to allow the bacteria to
grow. After 24 hours, the test groups were treated with controlled release 14%
doxycycline gel injecting the gel circumferentially over the surface of the implant
for 3 minutes, while the control groups were irrigated with sterile saline for 1
minute. The implants were then vortexed into triptych soy broth to allow the
bacteria to detach from the surface, diluted 1:100 and plated. Colony forming units
(CFU) were counted 48hours after incubation. Results: The use of a 14% doxycycline
gel minimized CFU counts compared to control groups, with the difference being
statistically significant (P < 0.05). The reduction of CFUs in the smooth test
group is more marked than in the rough test group, but the difference doesn't reach
statistically significance (P = 0.215). Conclusions: The use of 14% doxycycline gel
in implant surface decontamination was efficacious in this in-vitro study.
Adjunctive use of locally delivered 14% doxycycline gel might be a viable option in
the management of peri-implantitis and peri-implant mucositis considering its
efficacy in reducing bacterial colonization.
AN - rayyan-563562509
AU - Patianna, G.
AU - Valente, N. A.
AU - D'Addona, A.
AU - Andreana, S.
DO - 10.1002/JPER.17-0325
IS - 3
PY - 2018
SN - ["0022-3492", "1943-3670"]
SP - 325-330
ST - In vitro evaluation of controlled-release 14% doxycycline gel for
decontamination of machined and sandblasted acid-etched implants
TI - In vitro evaluation of controlled-release 14% doxycycline gel for
decontamination of machined and sandblasted acid-etched implants
VL - 89
Y2 - 3
ID - 15883
ER -
TY - JOUR
AN - rayyan-563561953
AU - Patil, A. G.
AU - Jobanputra, A. H.
DO - 10.1166/jbns.2015.1324
IS - 5
PY - 2015
SP - 401-408
ST - Formulation, characterization and evaluation of a thermoresponsive in situ
gel containing gallic acid-loaded chitosan nanoparticles for the treatment of
periodontal disease
T2 - Journal of Bionanoscience
TI - Formulation, characterization and evaluation of a thermoresponsive in situ
gel containing gallic acid-loaded chitosan nanoparticles for the treatment of
periodontal disease
84960410226&doi=10.1166%2fjbns.2015.1324&partnerID=40&md5=10ddaa48ed992693462a10f68
7d6865a
VL - 9
ID - 15327
ER -
TY - JOUR
AB - Objective: Periodontitis is an oral disease categorized by disturbance of
periodontal tissue and the creation of periodontal pockets. Thymol (TH) loaded
microsponge in situ gelling systems was formulated for local action in the
periodontal cavity for the management of periodontitis. Methods: Solvent
evaporation technique was utilized for the preparation of microsponges. A
Fractional Factorial Design (FFD) was used to screen the high risk variables
impacting the characteristics of the (TH) microsponges and further optimized using
Box-Behnken design. The optimized microsponges were then characterized by DSC, SEM,
antimicrobial activity, in-vitro release, and then incorporated in the in situ
gelling system. A ligature model was used to induce periodontitis in Sprague Dawley
rats. Results: The microsponges showed good characteristics, such as particle size,
entrapment efficiency, and mucoadhesiveness of 45 µm, 92.99 ± 0.2%, 96 ± 0.26%,
respectively. SEM revealed the spherical morphology of the microsponges with
sustained release of TH for 10h and antimicrobial activity against S. mutans and C.
albicans. Treatment with Thymol Loaded in situ Gel (THLMG) showed a decrease in
gingival inflammation and tooth mobility as well as in serum biochemical parameters
like serum C-reactive proteins, leucocyte count, alkaline phosphatase, and
tartrate-resistant acid phosphatase, when compared to disease group. The
histopathological study of the periodontium confirmed a significant reduction of
inflammation and alveolar bone destruction (p<0.05) in rats. Conclusion: THLMG
decreased the infiltration of inflammatory cells and prevented osteoclastogenesis
and osteoblast apoptosis, which further favored a decrease in inflammation and
alveolar bone loss in periodontitis. Thus, THLMG could be a better alternative to
synthetic antimicrobials and antibiotics to treat periodontitis.
AN - rayyan-563560032
AU - Patole, V. C.
AU - Chaudhari, S. P.
DO - 10.2174/1567201817666200804111614
IS - 1
KW - microscope
C reactive protein
eudragit
interleukin 1beta
thymol
animal cell
animal experiment
animal model
article
body temperature
Candida albicans
controlled study
factorial design
fractional factorial design
gingivitis
histopathology
leukocyte count
morphology
mucoadhesion
nonhuman
osteoclastogenesis
particle size
periodontal disease
periodontitis
periodontium
polymerization
protein blood level
rat
room temperature
viscosity
LA - English
PY - 2021
SN - ["1875-5704", "1567-2018"]
SP - 71-87
ST - Development of thymol microsponges loaded in situ gel for the treatment of
periodontitis
TI - Development of thymol microsponges loaded in situ gel for the treatment of
periodontitis
VL - 18
ID - 13406
ER -
TY - JOUR
AB - Purpose: The study was aimed to formulate eugenol-loaded polymeric
microsponges using eugenyl methacrylate (Eg-MA) incorporated in situ gelling system
for the treatment of periodontitis. Method: Eg-MA monomer was first synthesized by
reacting eugenol with methacryloyl chloride, which acted as a monomer and cross-
linking agent for preparing microsponges of Eg-MA using suspension polymerization
method. The formation of Eg-MA monomer was confirmed by FTIR. A 32 Box–Behnken
design was applied to optimize Eg-MA polymeric microsponges which were
characterized by SEM and antimicrobial activity. An optimized batch of polymeric
microsponges was incorporated into in situ gelling system which was evaluated on
the basis of pH, viscosity, gelling temperature, and mucoadhesion on the goat
buccal mucosa. Ligature-induced experimental periodontitis (EPD) was induced in
rats to assess the efficacy of the formulation. Results: SEM revealed the spherical
shape of Eg-MA microsponges with antibacterial activity against Streptococcus
mutans and potential to load eugenol with a drug content of 96.38 ± 0.09%. The
study of the eugenol-loaded microsponges in situ gel showed sustained release of
the drug up to 24 h with a mucoadhesive strength of 31 ± 0.13 N. Treatment with
eugenol-loaded Eg-MA polymeric microsponges decreased tooth mobility and gingival
inflammation in rats. The histological studies of the periodontium also confirmed
decrease in the infiltration of inflammatory cells and alveolar bone destruction (p
< 0.05) in EPD rats. Conclusion: Thus, a novel formulation using Eg-MA with
intrinsic antibacterial property was used to formulate eugenol-loaded polymeric
microsponges in situ gel for the management of periodontitis.
AN - rayyan-563559962
AU - Patole, V. C.
AU - Chaudhari, S. P.
DO - 10.1007/s12247-020-09456-y
IS - 3
KW - agar medium
chemical analyzer
syringe
carbomer
chlorhexidene gluconate
chloride
eugenol
gel
gluconic acid
hydrogel
methacrylic acid
methacrylic acid methyl ester
microsponge
monomer
poloxamer
unclassified drug
alveolar bone
animal cell
animal experiment
animal model
animal tissue
article
buccal mucosa
clinical assessment
clinical evaluation
controlled study
cross linking
drug efficacy
drug formulation
female
gelation
gingival index
gingivitis
inflammatory cell
mucoadhesion
nonhuman
particle size
periodontal disease
periodontium
pH
polymerization
rat
temperature
viscosity
LA - English
PY - 2021
SN - ["1939-8042", "1872-5120"]
SP - 408-418
ST - Eugenyl Methacrylate Microsponges Loaded with Eugenol Incorporated In Situ
Gel for Treatment of Periodontitis
T2 - J. Pharm. Innov.
TI - Eugenyl Methacrylate Microsponges Loaded with Eugenol Incorporated In Situ
Gel for Treatment of Periodontitis
VL - 16
ID - 13336
ER -
TY - JOUR
AB - Extensive efforts have recently been focused on targeting a drug or delivery
system in a particular region of the body for extended period of time, not only for
local targeting of drugs but also for the better control of systemic drug delivery.
The concept of periodontal drug delivery systems has fascinated many investigators
to the possible use of various polymers, which can overcome various physiological
barriers in long-term drug delivery, there by rendering the treatment more
effective and safe for local disorders and systemic problems. Presence of a smooth
and relatively immobile surface for placement of a bio-adhesive dosage form has
made periodontal route more suitable for sustained delivery of therapeutic agents
using bio-adhesive systems. Antibiotics, antiseptics and other poorly absorbable
drugs can be successfully delivered via periodontium for the treatment of
infectious periodontal diseases. The dosage forms include microparticles,
microspheres, adhesive gels, adhesive films, adhesive creams and ointments. Bio-
adhesive periodontal drug delivery system can also exert positive influence on drug
effectiveness by keeping the drug in the region proximal to its absorption window
and allow the targeting and localization of the drug at the specific site. © 2007
Bentham Science Publishers Ltd.
AN - rayyan-563560736
AU - Pattnaik, S.
AU - Panigrahi, L.
AU - Murthy, R. S. R.
DO - 10.2174/156720107782151214
IS - 4
KW - adhesive agent
amlexanox
minocycline
doxycycline hyclate
cetalkonium halide
choline salicylate
lidocaine
metronidazole
microsphere
lidocaine plus prilocaine
placebo
polymer
tetracycline
triamcinolone acetate
unclassified drug
clinical trial
cream
dental device
drug efficacy
drug formulation
drug release
drug safety
drug targeting
film coating
gel
human
microcapsule
ointment
periodontal disease
periodontium
priority journal
review
actisite
aphthasol
Arestin
atridox
bonjela
corsodyl
elyzol
oracort
oraqix
periochip
LA - English
PY - 2007
SN - 1567-2018
SP - 306-323
ST - Periodontal muco-adhesive formulations for the treatment of infectious
TI - Periodontal muco-adhesive formulations for the treatment of infectious
VL - 4
ID - 14110
ER -
TY - JOUR
AB - Fusobacterium nucleatum is a strict anaerobe and is indigenous of the human
oral cavity. This organism is commonly recovered from different monomicrobial and
mixed infections in humans and animals. In this study, the plasmid profile, the
plasmid stability and the penicillin-resistance association in oral F. nucleatum
isolated from periodontal patients, healthy subjects and Cebus apella monkeys were
evaluated. Forty-five F. nucleatum strains from patients, 38 from healthy subjects
and seven from C. apella were identified and analyzed. Plasmid extraction was
performed in all the isolated strains. These elements were found in 26.7% strains
from patients and one strain from C. apella. Strains from healthy subjects did not
show any plasmid. Most of strains showed two plasmid bands ranging from 4 to 16 Kb,
but digestions with endonucleases showed that they belonged to a single plasmid.
The plasmid profile was similar and stable in human and monkey strains. Also,
plasmids were classified into three groups according to size. Two strains were
positive to β-lactamase production and no plasmid DNA-hybridization with a β-
lactamase gene probe was observed, suggesting a chromosomal resistance.
AN - rayyan-563560890
AU - Paula, M. O.
AU - Gaetti-Jardim Jr, E.
AU - Avila-Campos, M. J.
DO - 10.1590/s0036-46652003000100002
IS - 1
KW - beta lactamase
endonuclease
plasmid DNA
adult
article
bacterial strain
bacterium isolation
Cebidae
controlled study
DNA hybridization
DNA restriction
human
mouth cavity
nonhuman
penicillin resistance
periodontitis
plasmid
Southern blotting
tooth plaque
LA - English
PY - 2003
SN - 0036-4665
SP - 5-9
ST - Plasmid profile in oral Fusobacterium nucleatum from humans and Cebus apella
monkeys
T2 - Rev. Inst. Med. Trop. Sao Paulo
TI - Plasmid profile in oral Fusobacterium nucleatum from humans and Cebus apella
monkeys
VL - 45
ID - 14264
ER -
TY - JOUR
AN - rayyan-563561522
AU - Păun, A.
AU - Monica Rusu, L.
AU - Moldovan, M.
AU - Sava, S.
AU - Dreanca, A.
AU - Bacali, C.
AU - Eugenia Badea, M.
AU - Borzan, C.
AU - Bâldea, I.
DO - 10.24193/subbchem.2023.2.06
IS - 2
PY - 2023
SP - 85-97
ST - THE ANTIOXIDANT EFFECT AND CHEMICAL COMPOSITION OF TWO EXPERIMENTAL
PHOTOSENSITIZERS IN INDUCED PERIODONTITIS
T2 - Studia Universitatis Babes-Bolyai Chemia
TI - THE ANTIOXIDANT EFFECT AND CHEMICAL COMPOSITION OF TWO EXPERIMENTAL
85166294672&doi=10.24193%2fsubbchem.2023.2.06&partnerID=40&md5=cd758fc30d940c68f284
7f1f2d66802d
VL - 2023
ID - 14896
ER -
TY - JOUR
AB - The aim of this study is to identify and test new natural photosensitizers
used in antibacterial photodynamic therapy due to the antimicrobial and antioxidant
effect they present. The experimental study was conducted on rats in which
periodontal disease was induced. As treatment, photodynamic therapy was used in the
presence of new developed natural photosensitizers based on oregano essential oil
and curcumin extract. Malondialdehyde as well as low and oxidized glutathione
levels were measured by spectrophotometry to assess oxidative stress in treated
groups of rats. New photosensitizers were characterized by modern testing methods,
using FTIR infrared spectroscopy, gas chromatography-mass spectrometry and UV-Vis
analysis. The results obtained suggest that the prooxidant effect is mainly due to
exposure to photodynamic therapy (irradiation) and leads to the antibacterial
therapeutic effect that is maintained even when applying gels with antioxidant
agents.
AN - rayyan-563562398
AU - Paun, A.
AU - Rusu, L. M.
AU - Moldovan, M.
AU - Sava, S.
AU - Dreanca, A.
AU - Bacali, C.
AU - Badea, M. E.
AU - Borzan, C.
AU - Baldea, I.
DO - 10.24193/subbchem.2023.2.06
IS - 2
PY - 2023
SN - 1224-7154
SP - 85-97
ST - THE ANTIOXIDANT EFFECT AND CHEMICAL COMPOSITION OF TWO EXPERIMENTAL
T2 - STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA
TI - THE ANTIOXIDANT EFFECT AND CHEMICAL COMPOSITION OF TWO EXPERIMENTAL
VL - 68
ID - 15772
ER -
TY - JOUR
AB - The objective of this study was to investigate the antimicrobial potency of
essential oil of Coriander against clinical samples isolated from the oral cavity
of various patients and to formulate a suitable topical preparation containing
Coriander oil. A total of 41 swabs were obtained from patients (age between 20 - 50
years) which were diagnosed with oral infections like periodontal abscess,
periapical abscess, chronic periodontities, periapical granuloma, dental caries,
root caries and plaque samples. These samples were inoculated on Blood agar, Mac-
conkeys agar and MRS Lactobacilli MRS agar, Mutans Sanguis agar, KF Streptococcal
agar at 37°C for 24-48 h aerobically except for KF Streptococcal agar and Mutans
Sanguis agar, which was incubated anaerobically at 37°C for 24-48 h. The isolates
were identified by standard microbiological procedures. The samples had positive
cultures of Streptococcus faecalis, Streptococcus sanguis, Streptococcus oralis,
Streptococcus mutans, Streptococcus salivarius, Lactobacilli, CONS. The
susceptibility of these isolates was determined using agar disc diffusion method
for zone of inhibition. The evaluation of antimicrobial potency was studied prior
to gel formulation to compare the changes in activity after incorporation in
polymer gel. The topical formulations were developed using different concentrations
of polymers and evaluated for various physicochemical parameters like pH, color,
clarity, viscosity, consistency, homogeneity, spread ability. The activity of oil
was not much affected by incorporation in gel. The gel showed promising
antimicrobial activity against the strains used for the study. © 2013 IRJP.
AN - rayyan-563560469
AU - Pawar Vinita, A.
AU - Bhagat Trupti, B.
AU - Toshniwal Mitesh, R.
AU - Mokashi Nitin, D.
AU - Khandelwal, K. R.
DO - 10.7897/2230-8407.041012
IS - 10
KW - agar
essential oil
adult
article
bacterium isolate
clinical article
coriander
dental caries
drug formulation
drug potency
drug screening
drug solubility
gel
human
Lactobacillus
middle aged
mouth cavity
mouth plaque
periodontal abscess
pH
physical chemistry
Streptococcus salivarius
viscosity
young adult
LA - English
PY - 2013
SN - 2230-8407
SP - 48-54
ST - Formulation and evaluation of dental gel containing essential oil of
coriander against oral pathogens
TI - Formulation and evaluation of dental gel containing essential oil of
coriander against oral pathogens
VL - 4
ID - 13843
ER -
TY - JOUR
AB - Aims: The main objective of this systematic review is to carry out a
qualitative synthesis of the available bibliography on the use of scaffolds used in
dentistry for the revitalisation treatment of immature teeth with open apex.
Material and methods: The search was carried out in the MEDLINE, Scopus and
Cochrane databases. The search included the terms ‘Pulp regeneration’ OR ‘Pulp
revitalisation’ AND ‘scaffold’. The inclusion criteria were articles published in
English, which carry out revitalisation treatments, with analysis of the results
obtained and comparison of them, carried out in humans, in immature permanent teeth
with open apex, and randomised clinical trials. The risk of bias assessment was
performed with the RoB2 guideline. Results: Of 769 studies, 10 met the inclusion
criteria. The scaffolds used were blood clot, platelet-rich plasma, platelet-rich
fibrin, and blood clots combined with different membranes such as collagen
membrane, collagen membrane and placentrex, chitosan membrane and hydrogel with
basic growth factor for fibroblasts. The clinical success rate is excellent for all
scaffolds used. The best scaffold for root development is platelet-rich plasma and
it is the scaffold with the highest percentage of response to vitality test.
Conclusion: Our results suggested that platelet-rich plasma is the preferred
scaffold of choice, although all the scaffolds analysed have acceptable results.
AN - rayyan-563559814
AU - Pecci-Lloret, M. P.
AU - Nandin-Muttoni, G.
AU - Pecci-Lloret, M. R.
AU - Guerrero-Gironés, J.
AU - Rodríguez-Lozano, F. J.
DO - 10.1016/j.aanat.2022.151936
calcium hydroxide
ciprofloxacin
fibrin
fissure sealant
glass ionomer
hydrogel
metronidazole
minocycline
unclassified drug
artificial membrane
blood clot
chitosan membrane
collagen membrane
deciduous tooth
dental pulp revitalization
human
meta analysis
periodontitis
review
systematic review
therapy effect
tooth abscess
tooth root
LA - English
PY - 2022
SN - ["1618-0402", "0940-9602"]
ST - Scaffolds for pulp revitalisation: A systematic review of randomized clinical
trials
T2 - Ann. Anat.
TI - Scaffolds for pulp revitalisation: A systematic review of randomized clinical
trials
VL - 243
ID - 13188
ER -
TY - JOUR
AB - The aim of the study was to compare the clinical and microbiological effects
of topical application of a metronidazole gel and a single session of subgingival
scaling in the treatment of adult periodontitis. An open, randomized controlled
clinical study design was employed. Each of 24 subjects received the 2 treatments
simultaneously each in 2 randomly selected quadrants of the dentition. The
metronidazole, 25% gel was applied subgingivally on days 0 and 7. Scaling was
carried out in one quadrant on day 0 and in one quadrant on day 7. Clinical and
microbiological examinations were carried out before treatment and on days 21, 49,
91, 133, and 175 of the experimental period. The microbiological analyses included
determination of total anaerobically cultivable bacteria, and relative proportions
of anaerobes, aerobes, black-pigmented anaerobic Gram negative rods, Actinobacillus
actinomycetemcomitans, streptococci, and spirochetes. Both treatments were
effective in reducing probing pocket depth and bleeding on probing. Metronidazole
tended to be a little better than scaling during the study period and the clinical
effects of both treatments persisted during the whole 6 months observation period.
Local metronidazole treatment induced a significant and long-lasting shift in the
subgingival flora towards a composition more compatible with health and comparable
to that obtained by mechanical debridement. Proportions of black pigmented
anaerobes including Prevotella intermedia, and the number of spirochetes were
significantly reduced after both treatments with a concomitant increase in the
proportions of streptococci. While scaling resulted in a statistically significant
increase in the proportion of A. actinomycetemcomitans, this was avoided after
metronidazole treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
AN - rayyan-563561150
AU - Pedrazzoli, V.
AU - Kilian, M.
AU - Karring, T.
IS - 9
KW - metronidazole
adult
aged
article
bacterium
Bacteroides
clinical trial
comparative study
drug effect
drug implant
female
follow up
gel
gingiva bleeding
human
male
microbiology
middle aged
periodontitis
Streptococcus
tooth plaque
LA - English
PY - 1992
SN - 0303-6979
SP - 715-722
ST - Comparative clinical and microbiological effects of topical subgingival
application of metronidazole 25% dental gel and scaling in the treatment of adult
periodontitis
TI - Comparative clinical and microbiological effects of topical subgingival
periodontitis
VL - 19
ID - 14524
ER -
TY - JOUR
AN - rayyan-563561147
AU - Pedrazzoli, V.
AU - Kilian, M.
AU - Karring, T.
IS - 9
KW - metronidazole
clinical article
conference paper
dentistry
human
periodontitis
LA - English
PY - 1992
SN - 0303-6979
SP - 715-722
ST - Comparative clinical and mirobiological effects of topical subgingival
periodontitis
TI - Comparative clinical and mirobiological effects of topical subgingival
periodontitis
VL - 19
ID - 14521
ER -
TY - JOUR
AB - Clindamycin, a lincosamide antibiotic, has been under-recognized as an
antimicrobial agent for use in dentistry. The aim of the present work was to
evaluate clinical efficacy of 2% clindamycin gel in addition to the basic
mechanical periodontal therapy. At baseline, scaling and root planing (SRP) was
performed at all 50 subjects (control group and test group). Clindamycin gel was
applied after SRP only in the test group. Clinical measurements including
periodontal pocket depth (PPD), clinical attachment level (CAL), bleeding on
probing (BOP) and plaque index (PI) were done at baseline, and at 3 and 6 months
after treatment. Compared to baseline, the PPD and CAL values significantly
decreased in the test group (p<0.05) and were statistically lower (p<0.05) compared
to control group. PPD reduction of 2.42 mm was obtained in the test group and could
be generally considered as clinically significant. A PPD reduction greater than 2
mm indicated that clindamycin gel could be used efficiently as an adjunct to SRP.
Also, between-group difference in BOP and PI scores was statistically significant 6
months after treatment. In conclusion, the application of clindamycin gel in
combination with SRP enhanced the efficacy of non surgical periodontal therapy in
reducing pocket depth and improving attachment levels in chronic periodontitis
subjects and had additional benefits over mechanical therapy alone.
AN - rayyan-563560399
AU - Pejčić, A.
AU - Kojović, D.
AU - Minić, I.
AU - Mirković, D.
AU - Denić, M.
AU - Stojanović, M.
IS - 1
KW - clindamycin
adult
article
bleeding on probing
clinical article
clinical evaluation
controlled study
dental procedure
drug efficacy
female
gel
gingiva bleeding
human
male
middle aged
periodontal disease
periodontal pocket
plaque index
scoring system
tooth plaque
treatment duration
LA - English
PY - 2015
SN - ["1333-9451", "0353-9466"]
SP - 46-51
ST - Therapeutic efficacy of clindamycin gel as an adjunct to scaling and root
planing therapy in chronic periodontal disease
T2 - Acta Clin. Croat.
TI - Therapeutic efficacy of clindamycin gel as an adjunct to scaling and root
planing therapy in chronic periodontal disease
VL - 54
ID - 13773
ER -
TY - JOUR
AB - Clindamycin, a lincosamide antibiotic, has been under-recognized as an
antimicrobial agent for use in dentistry. The aim of the present work was to
evaluate clinical efficacy of 2% clindamycin gel in addition to the basic
mechanical periodontal therapy. At baseline, scaling and root planing (SRP) was
performed at all 50 subjects (control group and test group). Clindamycin gel was
applied after SRP only in the test group. Clinical measurements including
periodontal pocket depth (PPD), clinical attachment level (CAL), bleeding on
probing (BOP) and plaque index (PI) were done at baseline, and at 3 and 6 months
after treatment. Compared to baseline, the PPD and CAL values significantly
decreased in the test group (p<0.05) and were statistically lower (p<0.05) compared
to control group. PPD reduction of 2.42 mm was obtained in the test group and could
be generally considered as clinically significant. A PPD reduction greater than 2
mm indicated that clindamycin gel could be used efficiently as an adjunct to SRP.
Also, between-group difference in BOP and PI scores was statistically significant 6
months after treatment. In conclusion, the application of clindamycin gel in
combination with SRP enhanced the efficacy of non surgical periodontal therapy in
reducing pocket depth and improving attachment levels in chronic periodontitis
subjects and had additional benefits over mechanical therapy alone.
AN - rayyan-563562229
AU - Pejcic, A.
AU - Kojovic, D.
AU - Minic, I.
AU - Mirkovic, D.
AU - Denic, M.
AU - Stojanovic, M.
IS - 1
PY - 2015
SN - ["0353-9466", "1333-9451"]
SP - 46-51
ST - THERAPEUTIC EFFICACY OF CLINDAMYCIN GEL AS AN ADJUNCT TO SCALING AND ROOT
PLANING THERAPY IN CHRONIC PERIODONTAL DISEASE
T2 - ACTA CLINICA CROATICA
TI - THERAPEUTIC EFFICACY OF CLINDAMYCIN GEL AS AN ADJUNCT TO SCALING AND ROOT
PLANING THERAPY IN CHRONIC PERIODONTAL DISEASE
VL - 54
Y2 - 3
ID - 15603
ER -
TY - JOUR
AB - OBJECTIVE: The aim of this study was to evaluate surface changes on dental
implant systems and ions release after immersion in fluoride and hydrogen peroxide.
METHODS: Ten implant-abutment assemblies were embedded in acrylic resin and cross-
sectioned along the implant vertical axis. Samples were wet ground and polished.
Delimited areas of groups of samples were immersed in 1.23% sodium fluoride gel (F)
or in 35% hydrogen peroxide (HP) for 16 min. Gels (n = 3) were collected from the
implant surfaces and analyzed by inductively coupled plasma mass spectrometry (ICP-
MS), to detect the concentration of metallic ions released from the implant
systems. Selected areas of the abutment and implant (n = 15) were analyzed by
atomic force microscopy (AFM) and scanning electron microscopy (SEM). RESULTS: SEM
images revealed surface topographic changes on implant-abutment joints after
immersion in fluoride. Implants showed excessive oxidation within loss of material,
while abutment surfaces revealed intergranular corrosion after immersion in
fluoride. ICP-MS results revealed a high concentration of Ti, Al, V ions in
fluoride after contact with the implant systems. Localized corrosion of implant
systems could not be detected by SEM after immersion in hydrogen peroxide although
the profilometry showed increase in roughness. ICP-MS showed the release of
metallic ions in hydrogen peroxide medium after contact with dental implants.
CONCLUSION: Therapeutical substances such as fluorides and hydrogen peroxide can
promote the degradation of titanium-based dental implant and abutments leading to
the release of toxic ions.
AN - rayyan-563560204
AU - Peñarrieta-Juanito, G.
AU - Sordi, M. B.
AU - Henriques, B.
AU - Dotto, M. E. R.
AU - Teughels, W.
AU - Silva, F. S.
AU - Magini, R. S.
AU - Souza, J. C. M.
DO - 10.1111/jre.12603
IS - 1
ion
sodium fluoride
titanium
corrosion
dental abutment
gel
immersion
mass spectrometry
surface property
time factor
tooth implant
LA - English
PY - 2019
SN - 1600-0765
SP - 46-52
ST - Surface damage of dental implant systems and ions release after exposure to
fluoride and hydrogen peroxide
TI - Surface damage of dental implant systems and ions release after exposure to
fluoride and hydrogen peroxide
VL - 54
ID - 13578
ER -
TY - JOUR
AB - Periodontitis is a common disease involving supportive structures of the
teeth in all groups, ethnicities, racesand both genders. Targeting to periodontal
pocket has made an important contribution to treat periodontitis, but has yetto
fully achieve its potential for better treating the periodontal diseases. This
review highlights the stages of diseases,etiology and different forms of
periodontal diseases for better understanding. This article then proceeds to cover
theperiodontal probes, systemic medications and local therapy. Additionally, we
focus on the recent advancements of localdrug delivery for treating periodontal
diseases. © 2011 Bentham Science Publishers Ltd.
AN - rayyan-563560582
AU - Pendekal, M. S.
AU - Tegginamat, P. K.
DO - 10.2174/157488511795304949
IS - 2
KW - Acacia catechu extract
Acanthopanacis cortex extract
Aloe vera extract
amoxicillin
cervitec
chlorhexidine
chlortetracycline
chlorzoin
ciprofloxacin
clindamycin
colocynth extract
Cucumis sativus extract
dentomycine
diclofenac
doxycycline
doxycycline hyclate
Echinacea pupurea extract
gatifloxacin
herbaceous agent
levofloxacin
lidocaine
metronidazole
minocycline
oxytetracycline
Panax notoginseng extract
penicillin G
periodontal plus ab
Pleurotus eryngii extract
silver nitrate
tetracycline
unclassified drug
unindexed drug
vinca rosea extract
antibiotic therapy
article
catarrhal gingivitis
debridement
diabetes mellitus
diarrhea
disease course
disease severity
dizziness
somnolence
drug efficacy
drug eruption
drug formulation
drug induced headache
drug megadose
drug potentiation
drug release
drug safety
drug saliva level
fiber
film coating
gel
gingivitis
Herxheimer reaction
human
hyperpigmentation
insomnia
liver toxicity
low birth weight
mouth flora
mouth plaque
nausea
necrotizing ulcerative periodontitis
nephrotoxicity
nonhuman
osteoporosis
periodontal disease
periodontal pocket
periodontitis
peripheral neuropathy
photosensitivity
pneumonia
prematurity
priority journal
respiratory tract disease
risk factor
taste disorder
thrush
tooth discoloration
ulcerative colitis
unspecified side effect
varnish
vertigo
vincent gingivitis
vomiting
actisite
arestin
atridox
elyzol
periochip
LA - English
PY - 2011
SN - ["1574-8855", "1065-7630"]
SP - 100-112
ST - Periodontitis and periodontal drug delivery systems: A review
T2 - Curr. Crug Ther.
TI - Periodontitis and periodontal drug delivery systems: A review
VL - 6
ID - 13956
ER -
TY - JOUR
AB - BACKGROUND: Scaling and root planing [SRP] being the mainstay of treatment of
periodontitis encompasses unambiguous impediments. antiseptics represent an aid to
nonsurgical periodontal therapy. OBJECTIVE: This randomized controlled, split mouth
study design with an observation period of three months aims to clinically evaluate
the efficacy of ozonised oil and chlorhexidine as an adjunct to SRP. METHODS:
Twenty-five patients of both sexes with an age range of 30-65 years diagnosed with
chronic periodontitis and having a periodontal probe depth (PD)≥5 mm and CAL≥3 mm
on at least 1 site in each quadrant were included in this randomised split mouth
design study. Patients were allocated in 2 experimental treatment groups as SRP +
chlorhexidine gel (control sites) and with SRP + ozone oil (test sites). The plaque
index (PI), gingival index (GI), and periodontal pocket depth (PPD), clinical
attachment level (CAL) were recorded at baseline data and after 30 days post-
baseline. RESULTS: The present study showed significant results in both the groups
with regards to the improvement in the clinical parameters. When comparison was
made between the two groups, it has been assessed that the use of the ozonized oil
in addition to SRP did not show significant differences when compared to
conventional SRP + chlorhexidine. CONCLUSION: For bye to SRP, ozonized oil can be
considered as a viable alternative to chlorhexidine in the treatment of
periodontitis, especially considering its low toxicity compared to chlorhexidine.
AN - rayyan-563559810
AU - Pendyala, G.
AU - Joshi, S.
AU - Mani, A.
AU - Dhole, S.
AU - Kale, P.
DO - 10.3233/JCB-220073
IS - 2
chlorhexidine
corticosteroid
olive oil
ozone
adult
article
clinical article
comparative study
controlled study
demographics
female
gingival index
human
local anesthesia
male
observational study
ozone therapy
plaque index
root planing
study design
LA - English
PY - 2022
SN - ["2352-3697", "2352-3689"]
SP - 105-112
ST - The denouement of ozone therapy vying to chlorhexidine in non surgical
periodontal therapy
T2 - J. Cell. Biotechnol.
TI - The denouement of ozone therapy vying to chlorhexidine in non surgical
periodontal therapy
VL - 8
ID - 13184
ER -
TY - JOUR
AB - The choice of one-visit versus two-visit root canal therapy for necrotic
teeth with apical periodontitis is a source of current debate. The primary
objective of this randomized controlled clinical trial was to compare radiographic
evidence of periapical healing after root canal therapy completed in one visit or
two visits with an interim calcium hydroxide/chlorhexidine paste dressing. Ninety-
seven patients met the inclusion criteria and consented to participate in this
study. Patients were randomly assigned to either the one-visit or two-visit group,
and root canal therapy was performed with a standardized protocol. Patients in the
two-visit group received an intracanal dressing of calcium hydroxide/chlorhexidine
paste. Sixty-three patients, 33 in the one-visit group and 30 in the two-visit
group, were evaluated at 12 months. The primary outcome measure was change in
apical bone density by using the periapical index (PAI). Secondary outcome measures
were proportion of teeth healed or improved in each group. Both groups exhibited
equally favorable periapical healing at 12 months, with no statistically
significant differences between groups.
AN - rayyan-563562492
AU - Penesis, V. A.
AU - Fitzgerald, P. I.
AU - Tayad, M. I.
AU - Wenckus, C. S.
AU - BeGole, E. A.
AU - Hnson, B. R.
DO - 10.1016/j.joen.2007.12.015
IS - 3
PY - 2008
SN - ["0099-2399", "1878-3554"]
SP - 251-257
ST - Outcome of one-visit and two-visit endodontic treatment of necrotic teeth
with apical periodontitis: A randomized controlled trial with one-year evaluation
TI - Outcome of one-visit and two-visit endodontic treatment of necrotic teeth
with apical periodontitis: A randomized controlled trial with one-year evaluation
VL - 34
Y2 - 3
ID - 15866
ER -
TY - JOUR
AB - Chitosan hydrogels containing hydroxypropyl methylcellulose (HPMC) and
toluidine blue O were prepared and assessed for their mucoadhesive property and
antimicrobial efficacy of photodynamic inactivation (PDI). Increased HPMC content
in the hydrogels resulted in increased mucoadhesiveness. Furthermore, we developed
a simple In Vitro 3D gingival model resembling the oral periodontal pocket to
culture the biofilms of Staphylococcus aureus (S. aureus), Aggregatibacter
actinomycetemcomitans (A. actinomycetemcomitans), and Porphyromonas gingivalis (P.
gingivalis). The PDI efficacy of chitosan hydrogel was examined against periodontal
biofilms cultured in this 3D gingival model. We found that the PDI effectiveness
was limited due to leaving some of the innermost bacteria alive at the non-
illuminated site. Using this 3D gingival model, we further optimized PDI procedures
with various adjustments of light energy and irradiation sites. The PDI efficacy of
the chitosan hydrogel against periodontal biofilms can significantly improve via
four sides of irradiation. In conclusion, this study not only showed the clinical
applicability of this chitosan hydrogel but also the importance of the light
irradiation pattern in performing PDI for periodontal disease.
AN - rayyan-563560327
AU - Peng, P. C.
AU - Hsieh, C. M.
AU - Chen, C. P.
AU - Tsai, T.
AU - Chen, C. T.
DO - 10.3390/ijms17111821
IS - 11
KW - chitosan
tolonium chloride
adhesion
article
biofilm
cell survival
controlled study
gingiva
hydrogel
illumination
irradiation
light
nonhuman
periodontal pocket
photodynamics
polymerization
Correct vps
SYPRO
LA - English
PY - 2016
SN - ["1422-0067", "1661-6596"]
ST - Assessment of photodynamic inactivation against periodontal bacteria mediated
by a chitosan hydrogel in a 3D gingival model
TI - Assessment of photodynamic inactivation against periodontal bacteria mediated
by a chitosan hydrogel in a 3D gingival model
VL - 17
ID - 13701
ER -
TY - JOUR
AB - Honey produced by bees has been used as medicine since ages and in more
recent times has been "rediscovered" indicating its potential in the treatment of
inflammatory diseases like gingivitis. This study was intended to compare the
effect of multiflower honey, jamun honey and chlorhexidine gluconate gel (0.2%) on
clinical levels of dental plaque in patients with gingivitis. Ninety healthy
patients aged between 18 to 50 years participated in the study and were randomly
divided into three groups, i.e. the multiflower honey group, the jamun honey group
and the chlorhexidine gluconate gel group. Once the Plaque index (PI), gingival
index (GI) and bleeding index (BI) were recorded at baseline & 7th day, Statistical
analysis was carried out using Paired t-test and one way ANOVA test. All the three
groups showed statistically significant reduction in all the parameters except for
plaque scores in jamun honey group, wherein significant reduction was not seen. The
mean plaque scores for groups I, II, III on baseline and day7 were 4.08, 4.32, 4.50
and 3.60, 4.18, 4.22 respectively. There was a statistically significant difference
with respect to reduction in BI scores amongst the three groups on day 7, while no
statistically significant difference of PI, GI scores were evident. On the other
hand both the honeys showed significant reduction of plaque and gingival indices
similar to chlorhexidine gluconate gel. Hence the findings of this study elicit
that honey can be used as a plaque control agent in patients with gingivitis.
AN - rayyan-563560286
AU - Penmetsa, G. S.
AU - Kalyani Kondepudi, L.
DO - 10.22376/ijpbs.2017.8.4.p55-60
IS - 4
adult
article
controlled study
female
flower
gel
gingival index
gingivitis
honey
human
male
plaque index
scoring system
Syzygium cumini
tooth plaque
treatment outcome
treatment response
LA - English
PY - 2017
SN - 0975-6299
SP - P55-P60
ST - Comparative evaluation of multiflower honey, jamun honey and chlorhexidine
gluconate gel (0.2%) on clinical levels of dental plaque: One week randomized
T2 - Int. J. Pharma Bio Sci.
TI - Comparative evaluation of multiflower honey, jamun honey and chlorhexidine
gluconate gel (0.2%) on clinical levels of dental plaque: One week randomized
VL - 8
ID - 13660
ER -
TY - JOUR
AN - rayyan-563561710
AU - Pereira, A. C.
AU - de Oliveira, M. L.
AU - C. L. Cerqueira-Neto, A. C.
AU - P. F. A. Gomes, B.
AU - De-Jesus-soares, A.
DO - 10.1590/1678-7757-2020-0217
PY - 2020
ST - Treatment outcomes of pulp revascularization in traumatized immature teeth
using calcium hydroxide and 2% chlorhexidine gel as intracanal medication
T2 - Journal of Applied Oral Science
TI - Treatment outcomes of pulp revascularization in traumatized immature teeth
85092528635&doi=10.1590%2f1678-7757-2020-
0217&partnerID=40&md5=b6a7147b85c59ba73462b9f109bfdf15
VL - 28
ID - 15084
ER -
TY - JOUR
AB - Objective: Pulp revascularization is an effective treatment for immature
necrotic teeth. Calcium hydroxide has been used in pulp revascularization as an
intracanal medication due to its antimicrobial action and the non exhibition of
crown discoloration and cytotoxicity for stem cells from the apical papilla. Our
study aimed to investigate the clinical success and quantitative radiographic
changes of root development in immature traumatized teeth using calcium hydroxide
plus 2% chlorhexidine gel as intracanal medication. Methodology: In this
retrospective study, 16 patients were treated with a standardized pulp
revascularization protocol. Calcium hydroxide and 2% chlorhexidine gel were
manipulated in a 1:1 (v/v) ratio and inserted into root canals with Lentulo spirals
(Dentsply Maillefer, Baillaigues, Switzerland). Patients were followed up for a
period from 9 to 36 months for the evaluation of clinical and radiological data.
Radiographic measurements of root length, root width, apical diameter, and MTA
placement from the apex were quantified using software Image]. Wilcoxon test and t-
test were used, according to nonparametric or parametric data, respectively, for
changes over time in root length, root width, and apical diameter. Results: Fifteen
teeth survived during the follow-up period (93.75%) and met the criteria for
clinical success. Although the changes seem to be very small in many cases,
significant increases in the average root length (14.28%, p<0.0001), root width
(8.12%, p=0.0196), and decrease in apical diameter (48.37%, p=0.0007) were
observed. MTA placement from the apex and age at the time of treatment was not
significantly associated with the quantitative radiographic outcomes. Conclusions:
Pulp revascularization in traumatized immature teeth treated with calcium hydroxide
plus 2% chlorhexidine gel as intracanal medication had high success and survival
rates, showing periodontal healing and resolution of signs and symptoms. However,
concerning the continued root development, the outcomes can still be considered
unpredictable.
AN - rayyan-563562520
AU - Pereira, A. C.
AU - de Oliveira, M. L.
AU - Cerqueira-Neto, Accl
AU - Gomes, Bpfa
DO - 10.1590/1678-7757-2020-0217
PY - 2020
SN - ["1678-7757", "1678-7765"]
T2 - JOURNAL OF APPLIED ORAL SCIENCE
VL - 28
ID - 15894
ER -
TY - JOUR
AB - OBJECTIVE: Pulp revascularization is an effective treatment for immature
intracanal medication due to its antimicrobial action and the non-exhibition of
plus 2% chlorhexidine gel as intracanal medication. METHODOLOGY: In this
placement from the apex were quantified using software ImageJ. Wilcoxon test and t-
changes over time in root length, root width, and apical diameter. RESULTS: Fifteen
significantly associated with the quantitative radiographic outcomes. CONCLUSIONS:
unpredictable.
AN - rayyan-563560161
AU - Pereira, A. C.
AU - Oliveira, M. L.
AU - Cerqueira-Neto, A. C. C. L.
DO - 10.1590/1678-7757-2020-0217
calcium hydroxide
chlorhexidine
adolescent
child
female
human
male
retrospective study
tooth apex
tooth pulp
tooth pulp disease
treatment outcome
vascularization
LA - English
PY - 2020
SN - 1678-7765
SP - e20200217
T2 - J Appl Oral Sci
VL - 28
ID - 13535
ER -
TY - JOUR
AB - OBJECTIVE: Pulp revascularization is an effective treatment for immature
plus 2% chlorhexidine gel as intracanal medication. METHODOLOGY: In this
changes over time in root length, root width, and apical diameter. RESULTS: Fifteen
significantly associated with the quantitative radiographic outcomes. CONCLUSIONS:
unpredictable.
AN - rayyan-563561338
AU - Pereira, A. C.
AU - Oliveira, M. L.
AU - Cerqueira-Neto, Accl
AU - Gomes, Bpfa
AU - A, D. E-Jesus-Soares
DO - 10.1590/1678-7757-2020-0217
J2 - J Appl Oral Sci
KW - Adolescent
*Calcium Hydroxide/therapeutic use
Child
*Chlorhexidine/therapeutic use
Dental Pulp/*blood supply
Dental Pulp Necrosis/drug therapy
Female
Humans
Male
Retrospective Studies
Tooth Apex
Treatment Outcome
LA - eng
N1 - Universidade Estadual Campinas - UNICAMP. Faculdade de Odontologia de
Piracicaba. Departamento de Odontologia Restauradora, área de Endodontia.
Piracicaba, SP, Brasil.; Universidade Estadual Campinas - UNICAMP. Faculdade de
Odontologia de Piracicaba. Departamento de Diagnóstico Oral, área de Radiologia
Oral, Piracicaba, SP, Brasil.; Universidade Estadual Campinas - UNICAMP. Faculdade
de Odontologia de Piracicaba. Departamento de Odontologia Restauradora, área de
Endodontia. Piracicaba, SP, Brasil.; Universidade Estadual Campinas - UNICAMP.
Faculdade de Odontologia de Piracicaba. Departamento de Odontologia Restauradora,
área de Endodontia. Piracicaba, SP, Brasil.; Universidade Estadual Campinas -
UNICAMP. Faculdade de Odontologia de Piracicaba. Departamento de Odontologia
Restauradora, área de Endodontia. Piracicaba, SP, Brasil.; Universidade Estadual
Campinas - UNICAMP. Faculdade de Odontologia de Piracicaba. Departamento de
Odontologia Restauradora, área de Endodontia. Piracicaba, SP, Brasil.; Universidade
Estadual Campinas - UNICAMP. Faculdade de Odontologia de Piracicaba. Departamento
de Odontologia Restauradora, área de Endodontia. Piracicaba, SP, Brasil.;
Universidade Estadual Campinas - UNICAMP. Faculdade de Odontologia de Piracicaba.
Departamento de Odontologia Restauradora, área de Endodontia. Piracicaba, SP,
Brasil.
PY - 2020
SP - e20200217
T2 - Journal of applied oral science : revista FOB
VL - 28
ID - 14712
ER -
TY - JOUR
AB - Objective Pulp revascularization is an effective treatment for immature
plus 2% chlorhexidine gel as intracanal medication. Methodology In this
changes over time in root length, root width, and apical diameter. Results Fifteen
significantly associated with the quantitative radiographic outcomes. Conclusions
unpredictable.
AN - rayyan-563559879
AU - Pereira, Andrea Cardoso
AU - Oliveira, Matheus Lima de
AU - Cerqueira-Neto, Ana Carolina C. L.
AU - Gomes, Brenda P. F. A.
AU - Ferraz, Caio Cezar Randi
AU - Almeida, José Flávio Affonso de
AU - Marciano, Marina Angélica
AU - De-Jesus-Soares, Adriana
DO - 10.1590/1678-7757-2020-0217
KW - Calcium hydroxide
Chlorhexidine
Endodontics
Regenerative endodontics
Tooth injuries
LA - en
PY - 2020
SN - 1678-7757
SP - e20200217-e20200217
T2 - J. appl. oral sci
77572020000100470
VL - 28
ID - 13253
ER -
TY - JOUR
AB - OBJECTIVES: The present controlled, single-blind study was performed to
assess and compare the clinical healing and the microbiological findings following
repeated intrasulcular applications of 1% metronidazole or 1% chlorhexidine gels in
persistent periodontal pockets previously treated by scaling and root planing
(SRP). MATERIAL AND METHODS: Sixty-three systemically healthy subjects, 25 males
and 38 females (mean age 48.4+/-7.2 years), diagnosed for chronic periodontitis
were enrolled in this study. They underwent SRP and received oral hygiene
instructions (OHI). Three months later, at baseline, a single persistent pocket
with a probing depth (PD) of 5-9 mm was chosen as the experimental site in each
patient; the subjects were stratified into three matched experimental groups on the
basis of the treatment to be performed, which consisted of the subgingival
administration of 1% metronidazole gel (MG, n=19), 1% chlorhexidine gel (CG, n=20)
or placebo gel (PG, n=24). The treatments consisted of four repeated
administrations of subgingival gels, each separated by 7 days, starting at the
baseline. Clinical assessment was performed at the baseline and at the 180-day
follow-up, after the end of treatment. For microbiological evaluations, subgingival
plaque was sampled from the experimental sites at baseline, prior to the first
subgingival gel administration, and at 7, 15, 30 and 90 days after the end of the
treatment (days 28, 36, 51 and 111 from baseline). RESULTS: Plaque accumulation did
not change significantly in all three groups. Bleeding on probing and clinical
attachment levels reduced in the MGs and CGs only. PD was significantly reduced by
the same amount in all experimental groups. In the MGs and CGs a remarkable
reduction in the frequencies of detection of several periodontopathic micoorganisms
was recorded after the treatment. The same was not seen for the PGs. CONCLUSIONS:
Subgingival administration of MG or CG, both at 1%, may have a role in the
management of persistent pockets during chronic periodontitis.
AN - rayyan-563560866
AU - Perinetti, G.
AU - Cordella, C.
AU - D'Ercole, S.
AU - Serra, E.
IS - 4
KW - chlorhexidine
metronidazole
placebo
adult
article
bacterial count
case control study
chronic disease
clinical trial
comparative study
controlled study
female
follow up
gel
gingiva bleeding
human
male
microbiology
middle aged
periodontal disease
periodontitis
tooth plaque
wound healing
LA - English
PY - 2004
SN - 0303-6979
SP - 273-281
ST - Clinical and microbiological effects of subgingival administration of two
active gels on persistent pockets of chronic periodontitis patients
TI - Clinical and microbiological effects of subgingival administration of two
active gels on persistent pockets of chronic periodontitis patients
VL - 31
ID - 14240
ER -
TY - JOUR
AB - The term "Phytotherapy" refers to the direct or indirect treatment of disease
through the use of plants and plant-derived products. Since the dawn of time,
people have employed herbs as a type of traditional medicine. Natural remedies
obtained from therapeutic plants have shown an abundant supply of biologically
active ingredients, several of which have served as the inspiration for creation of
novel molecules for different medications. A single herb exhibits multiple
benefits, such as anti-inflammatory, antibacterial, and antifungal activity, and
its use in dental treatment proves to be an effective adjuvant. The applications of
medicinal plants in endodontics are varied ranging from intracanal medicaments to
irrigants and retreatment agents. Various synthetic chemicals play a significant
role in disinfection in endodontics but also have undesirable properties such as
allergic potential, increased microbial resistance, toxicity, safety concerns and
bitter taste. Due to their widespread availability, low toxicity, and cost-
effectiveness, herbal remedies are now being used more frequently as part of dental
treatment and have experienced an exceptional surge in popularity in recent years.
Therefore, this article aims to provide a comprehensive review of various
phytochemicals and its endodontic applications, standardisation, possible side-
effects and its benefits as an adjunctive therapy.
AN - rayyan-563559771
AU - Periwal, A.
AU - Gaikwad, A.
AU - Pandit, V.
AU - Handa, A.
AU - Shinde, M.
DO - 10.7860/JCDR/2023/60166.17514
IS - 2
KW - adjuvant
alkaloid
antiinfective agent
camphor
dental material
emodin
flavonoid
hydrogel
inulin
lignin
phytochemical
plant extract
polyphenol
tea tree oil
terpene
thymol
warfarin
agar diffusion
Aloe vera
Alpinia
antifungal activity
Arctium lappa
biofilm
bitter taste
cell viability
conjunctivitis
contact dermatitis
coriander
dental practice
dental procedure
dentistry
disinfection
dizziness
endodontics
garlic
gingivitis
headache
herb
herbal medicine
human
medicinal plant
Myrtaceae
periodontal disease
phytochemistry
phytotherapy
quality control
review
tooth extraction
wound healing
zone of inhibition
LA - English
PY - 2023
SN - ["0973-709X", "2249-782X"]
SP - ZE14-ZE19
ST - Phytotherapy-A Drive towards Green and Clean Dentistry!
TI - Phytotherapy-A Drive towards Green and Clean Dentistry!
VL - 17
ID - 13145
ER -
TY - JOUR
AB - Objectives: To assess the microbiological outcome of local administration of
minocycline hydrochloride microspheres 1 mg (Arestin((R))) in cases with peri-
implantitis and with a follow-up period of 12 months. Material and methods: After
debridement, and local administration of chlorhexidine gel, peri-implantitis cases
were treated with local administration of minocycline microspheres (Arestin((R))).
The DNA-DNA checkerboard hybridization method was used to detect bacterial presence
during the first 360 days of therapy. Results: At Day 10, lower bacterial loads for
6/40 individual bacteria including Actinomyces gerensceriae (P < 0.1), Actinomyces
israelii (P < 0.01), Actinomyces naeslundi type 1 (P < 0.01) and type 2 (P < 0.03),
Actinomyces odontolyticus (P < 0.01), Porphyromonas gingivalis (P < 0.01) and
Treponema socranskii (P < 0.01) were found. At Day 360 only the levels of
Actinobacillus actinomycetemcomitans were lower than at baseline (mean difference:
1 x 10(5); SE difference: 0.34 x 10(5), 95% CI: 0.2 x 10(5) to 1.2 x 10(5); P <
0.03). Six implants were lost between Days 90 and 270. The microbiota was
successfully controlled in 48%, and with definitive failures (implant loss and
major increase in bacterial levels) in 32% of subjects. Conclusions: At study
endpoint, the impact of Arestin((R)) on A. actinomycetemcomitans was greater than
the impact on other pathogens. Up to Day 180 reductions in levels of Tannerella
forsythia, P. gingivalis, and Treponema denticola were also found. Failures in
treatment could not be associated with the presence of specific pathogens or by the
total bacterial load at baseline. Statistical power analysis suggested that a case
control study would require approximately 200 subjects.
AN - rayyan-563562596
AU - Persson, G. R.
AU - Salvi, G. E.
AU - Lang, N. P.
DO - 10.1111/j.1600-0501.2006.01269.x
IS - 4
PY - 2006
SN - 0905-7161
SP - 386-393
ST - Antimicrobial therapy using a local drug delivery system (Arestin (R)) in the
treatment of peri-implantitis. I: microbiological outcomes
T2 - CLINICAL ORAL IMPLANTS RESEARCH
TI - Antimicrobial therapy using a local drug delivery system (Arestin (R)) in the
treatment of peri-implantitis. I: microbiological outcomes
VL - 17
Y2 - 8
ID - 15970
ER -
TY - JOUR
AB - Objectives: To assess the microbiological outcome of local administration of
minocycline hydrochloride microspheres 1 mg (Arestin®) in cases with peri-
implantitis and with a follow-up period of 12 months. Material and methods: After
were treated with local administration of minocycline microspheres (Arestin®). The
DNA-DNA checkerboard hybridization method was used to detect bacterial presence
during the first 360 days of therapy. Results: At Day 10, lower bacterial loads for
6/40 individual bacteria including Actinomyces gerensceriae (P<0.1), Actinomyces
israelii (P<0.01), Actinomyces naeslundi type 1 (P<0.01) and type 2 (P<0.03),
Actinomyces odontolyticus (P<0.01), Porphyromonas gingivalis (P<0.01) and Treponema
socranskii (P<0.01) were found. At Day 360 only the levels of Actinobacillus
actinomycetemcomitans were lower than at baseline (mean difference: 1 × 105; SE
difference: 0.34 × 105, 95% CI: 0.2 × 105 to 1.2 × 105; P<0.03). Six implants were
lost between Days 90 and 270. The microbiota was successfully controlled in 48%,
and with definitive failures (implant loss and major increase in bacterial levels)
in 32% of subjects. Conclusions: At study endpoint, the impact of Arestin® on A.
actinomycetemcomitans was greater than the impact on other pathogens. Up to Day 180
reductions in levels of Tannerella forsythia, P. gingivalis, and Treponema
denticola were also found. Failures in treatment could not be associated with the
presence of specific pathogens or by the total bacterial load at baseline.
Statistical power analysis suggested that a case control study would require
approximately 200 subjects. Copyright © Blackwell Munksgaard 2006.
AN - rayyan-563560765
AU - Persson, G. R.
AU - Salvi, G. E.
AU - Lang, N. P.
DO - 10.1111/j.1600-0501.2006.01269.x
IS - 4
bacterial DNA
minocycline
adult
aged
article
chemistry
dental surgery
DNA probe
drug effect
epidemiology
female
human
male
methodology
microbiology
middle aged
periodontitis
tooth implantation
treatment outcome
LA - English
PY - 2006
SN - ["0905-7161", "1600-0501"]
SP - 386-393
ST - Antimicrobial therapy using a local drug delivery system (Arestin®) in the
treatment of peri-implantitis. I: Microbiological outcomes
TI - Antimicrobial therapy using a local drug delivery system (Arestin®) in the
VL - 17
ID - 14139
ER -
TY - JOUR
AB - OBJECTIVES: To assess the microbiological outcome of local administration of
minocycline hydrochloride microspheres 1 mg (Arestin) in cases with peri-
implantitis and with a follow-up period of 12 months. MATERIAL AND METHODS: After
were treated with local administration of minocycline microspheres (Arestin). The
DNA-DNA checkerboard hybridization method was used to detect bacterial presence
during the first 360 days of therapy. RESULTS: At Day 10, lower bacterial loads for
6/40 individual bacteria including Actinomyces gerensceriae (P<0.1), Actinomyces
israelii (P<0.01), Actinomyces naeslundi type 1 (P<0.01) and type 2 (P<0.03),
Actinomyces odontolyticus (P<0.01), Porphyromonas gingivalis (P<0.01) and Treponema
socranskii (P<0.01) were found. At Day 360 only the levels of Actinobacillus
actinomycetemcomitans were lower than at baseline (mean difference: 1x10(5); SE
difference: 0.34x10(5), 95% CI: 0.2x10(5) to 1.2x10(5); P<0.03). Six implants were
lost between Days 90 and 270. The microbiota was successfully controlled in 48%,
and with definitive failures (implant loss and major increase in bacterial levels)
in 32% of subjects. CONCLUSIONS: At study endpoint, the impact of Arestin on A.
actinomycetemcomitans was greater than the impact on other pathogens. Up to Day 180
reductions in levels of Tannerella forsythia, P. gingivalis, and Treponema
denticola were also found. Failures in treatment could not be associated with the
presence of specific pathogens or by the total bacterial load at baseline.
Statistical power analysis suggested that a case control study would require
approximately 200 subjects.
AN - rayyan-563561443
AU - Persson, G. R.
AU - Salvi, G. E.
AU - Heitz-Mayfield, L. J.
AU - Lang, N. P.
DO - 10.1111/j.1600-0501.2006.01269.x
IS - 4
J2 - Clin Oral Implants Res
KW - Adult
Aged
Anti-Bacterial Agents/*chemistry
DNA Probes/analysis
DNA, Bacterial/analysis/drug effects
*Dental Implants
*Dental Restoration Failure
Drug Delivery Systems/methods
Epidemiologic Methods
Female
Humans
Male
Middle Aged
Minocycline/*chemistry
Periodontitis/*drug therapy/microbiology
Treatment Outcome
LA - eng
N1 - University of Berne, Berne, Switzerland. rutger.persson@zmk.unibe.ch
PY - 2006
SN - 0905-7161 (Print)
SP - 386-93
ST - Antimicrobial therapy using a local drug delivery system (Arestin) in the
T2 - Clinical oral implants research
TI - Antimicrobial therapy using a local drug delivery system (Arestin) in the
VL - 17
Y2 - 8
ID - 14817
ER -
TY - JOUR
AB - Microorganisms coexist in a complex milieu of bacteria, fungi, archaea, and
viruses on or within the human body, often as multifaceted polymicrobial biofilm
communities at mucosal sites and on abiotic surfaces. Only recently have we begun
to appreciate the complicated biofilm phenotype during infection; moreover, even
less is known about the interactions that occur between microorganisms during
polymicrobial growth and their implications in human disease. Therefore, this
review focuses on polymicrobial biofilm-mediated infections and examines the
contribution of bacterial-bacterial, bacterial-fungal, and bacterial-viral
interactions during human infection and potential strategies for protection against
such diseases. © 2012, American Society for Microbiology. All Rights Reserved.
AN - rayyan-563560561
AU - Peters, B. M.
AU - Jabra-Rizk, M. A.
AU - O'May, G. A.
AU - William Costerton, J.
AU - Shirtliff, M. E.
DO - 10.1128/CMR.00013-11
IS - 1
DNA vaccine
pertussis toxin
Pneumococcus vaccine
polymicrobial vaccine
RNA 16S
synbiotic agent
cystic fibrosis transmembrane conductance regulator
unclassified drug
vaccine
virulence factor
antibiotic therapy
bacterial infection
bacterial overgrowth
bacterial strain
bacterial superinfection
bacteriophage
bacterium culture
biofilm
Burkholderia cepacia infection
Candida albicans
clinical feature
coaggregation
cystic fibrosis
debridement
dental caries
device infection
diabetic foot
Fusobacteria
human
hyperbaric oxygen therapy
immunocompromised patient
intestine flora
lung infection
maggot therapy
microbial adhesion
microbial growth
microbial identification
microbial population dynamics
microbiological phenomena and functions
mouth cavity
mycosis
nonhuman
organismal interaction
otitis media
parenteral nutrition
pathogenesis
periodontitis
phage therapy
phenotypic variation
review
sequence analysis
stomach pH
stomatitis
therapy
tooth disease
upper respiratory tract infection
vaccination
vacuum assisted closure
virus infection
wound infection
LA - English
PY - 2012
SN - ["0893-8512", "1098-6618"]
SP - 193-213
ST - Polymicrobial interactions: Impact on pathogenesis and human disease
T2 - Clin. Microbiol. Rev.
TI - Polymicrobial interactions: Impact on pathogenesis and human disease
VL - 25
ID - 13935
ER -
TY - JOUR
AB - The effects of a polymer based antimicrobial releasing varnish Cervitec were
investigated against different gram-positive and gram-negative bacterial strains as
well as a yeast using the agar diffusion inhibitory test (ADT-test in vitro). As
positive controls a 1% chlorhexidine gel and 1% aqueous solution of thymol and a
placebo polymer varnish without active agents were employed. The test experimental
varnish containing 1% chlorhexidine and 1% thymol showed antimicrobial activity
against all gram-positive and gram-negative microorganisms tested including one
Candida strain. The positive controls were similar in effect compared to the test
varnish. No antimicrobial effect was observed with the placebo varnish without
active ingredients. Toothpicks and dental floss treated with the test varnish
showed an antimicrobial effect against S. mutans even after storing in room
temperature up to 12 months. The results from this study support earlier laboratory
studies that chlorhexidine and thymol diffuse out of the experimental varnish and
that the varnish is active against various of oral pathogens. The possibility to
use toothpicks or dental floss impregnated with the varnish with the aim to become
chemotherapeutically active against periodontal diseases as well as against dental
caries, is promising and should be tested in vivo.
AN - rayyan-563561142
AU - Petersson, L. G.
AU - Edwardsson, S.
AU - Arends, J.
IS - 5
KW - Cervitec
chlorhexidine
placebo
thymol
article
Bacteroides
Candida albicans
dental device
drug combination
drug effect
gel
Lactobacillus casei
Streptococcus
surface property
time
LA - English
PY - 1992
SN - 0347-9994
SP - 183-189
ST - Antimicrobial effect of a dental varnish, in vitro
T2 - Swed Dent J
TI - Antimicrobial effect of a dental varnish, in vitro
VL - 16
ID - 14516
ER -
TY - JOUR
AB - The effects of a polymer based antimicrobial releasing varnish Cervitec(R)
were investigated against different grampositive and gramnegative bacterial strains
as well as a yeast using the agar diffusion inhibitory test (ADT-test in vitro). As
positive controls a 1 % chlorhexidine gel and 1 % aqueous solution of thymol and a
placebo polymer varnish without active agents were employed. The test experimental
varnish containing 1 % chlorhexidine and 1 % thymol showed antimicrobial activity
against all grampositive and gramnegative microorganisms tested including one
Candida strain. The positive controls were similar in effect compared to the test
varnish. No antimicrobial effect was observed with the placebo varnish without
active ingredients. Toothpicks and dental floss treated with the test varnish
showed an antimicrobial effect against S. mutans even after storing in room
temperature up to 12 months. The results from this study support earlier laboratory
studies that chlorhexidine and thymol diffuse out of the experimental varnish and
that the varnish is active against various of oral pathogenes. The possibility to
use toothpicks or dental floss impregnated with the varnish with the aim to become
chemotherapeutically active against periodontal diseases as well as against dental
caries, is promising and should be tested in vivo.
AN - rayyan-563562391
AU - Petersson, L. G.
AU - Edwardsson, S.
AU - Arends, J.
IS - 5
PY - 1992
SN - 0347-9994
SP - 183-189
ST - ANTIMICROBIAL EFFECT OF A DENTAL VARNISH, INVITRO
T2 - SWEDISH DENTAL JOURNAL
TI - ANTIMICROBIAL EFFECT OF A DENTAL VARNISH, INVITRO
VL - 16
ID - 15765
ER -
TY - JOUR
AB - This study aims to test a photodynamic protocol based on a gel containing
aminolevulinic acid followed by red-LED (ALAD-PDT) irradiation on human gingival
fibroblasts (hGFs) and osteoblasts (hOBs) cultured on a porcine acellular dermal
matrix membrane (PADMM). In the previous literature, ALAD-PDT showed solid
antibacterial activity and proliferative induction on HGFs cultured on plates and
HOBs cultured on a cortical lamina. PADMMs are used in dentistry and periodontology
to treat gingival recessions and to increase the tissue thickness in the case of a
thin biotype without the risks or postoperative discomfort associated with
connective tissue grafts. However, one of the possible complications in this type
of surgery is represented by bacterial invasion and membrane exposition during the
healing period. We hypothesized that the addition of ALAD-PDT to PADMMs could
enhance more rapid healing and decrease the risks connected with bacterial
invasion. In periodontal surgery, PADMMs are inserted after a full-thickness flap
elevation between the bone and the flap. Consequently, all procedures were
performed in parallel on hOBs and hGFs obtained by dental patients. The group
control (CTRL) was represented by the unexposed cells cultured on the membranes,
group LED (PDT) were the cells subjected to 7 min of red LED irradiation, and ALAD-
PDT were the cells subjected to 45 min of ALAD incubation and then to 7 min of red
LED irradiation. After treatments, all groups were analyzed for MTT assay and
subjected to histological examination at 3 and 7 days and to the SEM observations
at 3, 7, and 14 days. Different bone mineralization assays were performed to
quantify the effects of ALAD-PDT on hOBs: ALP activity, ALP gene expression,
osteocalcin, and alizarin red. The effects of ALAD-PDT on hGFs were evaluated by
quantifying collagen 1, fibronectin, and MMP-8. Results showed that ALAD-PDT
promoted cellular induction, forming a dense cellular network on hOBs and hGFs, and
the assays performed showed statistically significantly higher values for ALAD-PDT
with respect to LED alone and CTRLs. In conclusion, ALAD-PDT could represent a
promising aid for enhancing the healing of gingival tissues after PADMM
applications.
AN - rayyan-563561447
AU - Petrini, M.
AU - D'Amico, E.
AU - Aceto, G. M.
AU - Karaban, M.
AU - Felice, P.
AU - Piattelli, A.
AU - Barone, A.
AU - Iezzi, G.
DO - 10.3390/gels9070584
IS - 7
J2 - Gels
LA - eng
N1 - Department of Medical, Oral and Biotechnological Sciences, University G.
d'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.; Department of Medical, Oral and
Biotechnological Sciences, University G. d'Annunzio of Chieti-Pescara, 66100
Chieti, Italy.; Department of Medical, Oral and Biotechnological Sciences,
University G. d'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.; Department of
Medical, Oral and Biotechnological Sciences, University G. d'Annunzio of Chieti-
Pescara, 66100 Chieti, Italy.; Department of Biomedical and Neuromotor Sciences,
University of Bologna, 40126 Bologna, Italy.; Department of Biomedical and
Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy.; School of
Dentistry, Saint Camillus International University of Health and Medical Sciences,
00131 Rome, Italy.; Department of Surgical, Medical, Molecular Pathologies and of
the Critical Needs, School of Dentistry, University of Pisa, 56126 Pisa, Italy.;
Complex Unit of Stomatology and Oral Surgery, University Hospital of Pisa, 56126
Pisa, Italy.; Department of Medical, Oral and Biotechnological Sciences, University
G. d'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.
PY - 2023
ST - Photodynamic Therapy with Aminolevulinic Acid Enhances the Cellular Activity
of Cells Cultured on Porcine Acellular Dermal Matrix Membranes Used in
Periodontology
TI - Photodynamic Therapy with Aminolevulinic Acid Enhances the Cellular Activity
Periodontology
VL - 9
Y2 - 7 y3 - 20
ID - 14821
ER -
TY - JOUR
AN - rayyan-563561479
AU - Petrini, M.
AU - D’Amico, E.
AU - Aceto, G. M.
AU - Karaban, M.
AU - Felice, P.
AU - Piattelli, A.
AU - Barone, A.
AU - Iezzi, G.
DO - 10.3390/gels9070584
IS - 7
PY - 2023
ST - Photodynamic Therapy with Aminolevulinic Acid Enhances the Cellular Activity
Periodontology
T2 - Gels
TI - Photodynamic Therapy with Aminolevulinic Acid Enhances the Cellular Activity
Periodontology
85166325981&doi=10.3390%2fgels9070584&partnerID=40&md5=5e310bbbebb2a74d3aa8ba02a88b
0d48
VL - 9
ID - 14853
ER -
TY - JOUR
AB - OBJECTIVES Peri-implant disease includes both a reversible inflammatory
process, called peri-mucositis and peri-implantitis, in which progressive
reabsorption of the supporting bone causes irreversible effects. The etiological
factors of peri-implant disease follow, in part, those of periodontal pathology.
The high presence of biofilm around the implants turns out to be the predisposing
factor, but from a microbiological point of view, it is a more heterogeneous and
complex infection, consisting mainly of gram-negative bacteria, compared to
periodontitis. Currently, the decontamination and disinfection of the implant
surface represent the first treatment step, however, this process is made very
difficult, both for the difficulty of accessing the operating field, and for the
surface roughness of the implants, and for the resistance by the bacterial biofilm
upon penetration by antibiotics. Due to these factors, the treatment of peri-
implant disease still represents a great challenge for the dentist and the study of
new technologies is still ongoing in order to find increasingly effective tools.
Among these, the use of light-based devices, such as LEDs or lasers, with or
without the additional use of photosensitizers, has shown results that are still
controversial, but albeit encouraging. In particular, previous literature has shown
that the association between 5-aminolevulinic acid and red LED light has a high
antibacterial effect against gram-positive bacteria. However, the efficacy against
gram-negative bacteria, the main actors in the etiology of peri-implant disease, is
controversial. The aim of this study is to evaluate the effect of a new gel
containing 5-aminolevulinic acid, tested at different concentrations and exposed to
different irradiation times of red LED, on Pseudomonas aeruginosa, a gram-negative
bacterium, particularly important for its resistance to antibiotics and, in
dentistry, for its frequent association with peri-implantitis. MATERIALS AND
METHODS Pseudomonas aeruginosa was cultivated in vitro and subjected to different
protocols which included: incubation with Aladent gel (Alpha-strumenti, Melzo,
Milan) at different concentrations and/or irradiation with red LED light (630 nm).
The count of colony-forming bacterial units (CFU/mL) was measured and comparisons
were made between the different groups. RESULTS AND CONCLUSIONS One hour of
incubation with new gel followed by 7 minutes of irradiation with red LED light
allowed the total elimination of bacteria. The red LED light irradiation, without
adding gel, significantly reduced the bacterial count, compared to the controls.
Even the use of new gel alone, without irradiation, was able to promote a
significant reduction in the bacterial count, proportional to the gel
concentration. In conclusion, it is possible deduce that the new gel is effective
in significantly reducing in vitro gram-negative bacteria such as Pseudomonas
aeruginosa. The association of 7 minutes of irradiation with red LED light with the
gel allows for the total inactivation of the bacteria. CLINICAL SIGNIFICANCE The
combination of new gel and irradiation with red LED light is an additional tool for
bacterial inactivation in the treatment of dental implants contaminated and/or
affected by mucositis and peri-implantitis
AN - rayyan-563562569
AU - Petrini, M.
AU - Mancini, M.
AU - Iezzi, G.
AU - Piattelli, A.
AU - Di Campli, E.
AU - D'Ercole, S.
DO - 10.19256/d.cadmos.05.2021.06
IS - 5
PY - 2021
SN - 0011-8524
SP - 358-365
ST - 5-aminolevulinic acid and LED against peri-implant disease
T2 - DENTAL CADMOS
TI - 5-aminolevulinic acid and LED against peri-implant disease
VL - 89
Y2 - 5
ID - 15943
ER -
TY - JOUR
AB - OBJECTIVES Peri-implant disease includes both a reversible inflammatory
process, called peri-mucositis and peri-im plantitis, in which progressive reab-
sorption of the supporting bone causes irreversible effects. The etiological
factors of peri-implant disease follow, in part, those of periodontal pathology.
The high presence of biofilm around the implants turns out to be the predisposing
factor, but from a microbiological point of view, it is a more heterogeneous and
complex infection, consisting mainly of gram-negative bacteria, compared to
periodontitis. Currently, the decontamination and disinfection of the implant
surface represent the first treatment step, however, this process is made very
difficult, both for the difficulty of ac cessing the operating field, and for the
surface roughness of the im plants, and for the resistance by the bacterial biofilm
upon penetra tion by antibiotics. Due to these factors, the treatment of peri-
implant disease still rep resents a great challenge for the dentist and the study
of new tech nologies is still ongoing in order to find increasingly effective
tools. Among these, the use of light-based devices, such as LEDs or lasers, with or
without the additional use of photosensitizers, has shown results that are still
controversial, but albeit encouraging. In particular, previous literature has shown
that the association between 5-aminolevulinic acid and red LED light has a high
antibacterial effect against gram-positive bacteria. However, the efficacy against
gram-negative bacteria, the main actors in the etiology of peri-implant disease, is
controversial. The aim of this study is to evaluate the effect of a new gel
containing 5-aminolevulinic acid, tested at dif ferent concentrations and exposed
to different irradiation times of red LED, on Pseudomonas aeruginosa, a gram-
negative bacterium, partic ularly important for its resistance to antibiotics and,
in dentistry, for its frequent association with peri-im plantitis. MATERIALS AND
METHODS Pseudomonas aeruginosa was cultivated in vitro and subjected to different
protocols which included: incubation with Aladent gel (Alpha-strumenti, Melzo,
Milan) at different concentrations and/or irradiation with red LED light (630 nm).
The count of colony-forming bacterial units (CFU/mL) was measured and comparisons
were made between the different groups. RESULTS AND CONCLUSIONS One hour of
incubation with new gel followed by 7 minutes of irradi ation with red LED light
allowed the total elimination of bacteria. The red LED light irradiation, without
adding gel, significantly reduced the bacterial count, compared to the controls.
Even the use of new gel alone, without irradiation, was able to pro-mote a
significant reduction in the bacterial count, proportional to the gel
concentration. In conclusion, it is possible deduce that the new gel is effective
in significantly reducing in vitro gram-negative bacteria such as Pseudomonas
aeruginosa. The association of 7 minutes of irradiation with red LED light with the
gel allows for the total inactivation of the bacteria. CLINICAL SIGNIFICANCE The
combination of new gel and irradiation with red LED light is an additional tool for
bacterial inactivation in the treatment of dental implants contaminated and/or
affected by mucositis and peri-implantitis.
AN - rayyan-563560035
AU - Petrini, M.
AU - Mancini, M.
AU - Iezzi, G.
AU - Piattelli, A.
AU - Di Campli, E.
AU - D’ercole, S.
DO - 10.19256/d.cadmos.05.2021.06
IS - 5
KW - dental light
aminolevulinic acid
article
bacterial clearance
bacterial count
controlled study
in vitro study
nonhuman
periimplantitis
LA - Italian
PY - 2021
SN - 0011-8524
SP - 358-365
ST - 5-aminolevulinic acid and led against peri-implant disease
T2 - Acido 5-aminolevulinico e led contro la malattia peri-implantare
TI - 5-aminolevulinic acid and led against peri-implant disease
VL - 89
ID - 13409
ER -
TY - JOUR
AB - Eudragit RS (ERS), a quaternary polyacrylate positively charged polymer,
exhibits a very low permeability and swells in aqueous media independently of pH
without dissolving. Owing to its high solubility in N-methyl pyrrolidone (NMP), it
was interesting to apply as polymer matrix for solvent-exchanged in situ forming
gel. The aim of this research was to prepare in situ forming gels from ERS to
deliver the antimicrobial agents (doxycycline hyclate, metronidazole, and benzoyl
peroxide) for periodontitis treatment. They were evaluated for viscosity and
rheology, gel formation, syringeability, drug release, and antimicrobial
activities. The solvent exchange between NMP and an external aqueous simulated
gingival crevicular fluid stimulated the dissolved ERS transforming into the opaque
rigid gel. Antimicrobial agent loaded ERS systems exhibited Newtonian flow with
acceptable syringeability. The higher-loaded ERS promoted the more prolongation of
drug release because of the retardation of water diffusion into the precipitated
matrix. Antimicrobial activities against Staphylococcus aureus, Escherichia coli,
Candida albicans, Streptococcus mutans, and Porphyromonas gingivalis depended on
type of drugs and test microorganisms. Doxycycline hyclate loaded ERS systems
showed these activities greater than the others; however, all of them could inhibit
all test microorganisms. Thus, the solvent exchange-induced in situ forming gels
comprising ERS-antimicrobial drugs exhibited potential use as localized delivery
systems for periodontitis treatment.
AN - rayyan-563560311
AU - Phaechamud, T.
AU - Jantadee, T.
AU - Mahadlek, J.
AU - Charoensuksai, P.
AU - Pichayakorn, W.
DO - 10.1208/s12249-016-0534-y
IS - 2
ampicillin
benzoyl peroxide
clotrimazole
doxycycline hyclate
eudragit rs
metronidazole
solvent
analyzer
article
Candida albicans
controlled study
dialysis membrane
diffusion
drug degradation
drug formulation
drug release
drug screening
Escherichia coli
flow kinetics
gelation
gingivitis
nonhuman
periodontitis
pH
priority journal
procedures
shear stress
software
solvent exchange
surface property
syringeability test
viscosity
Scientist
TA.XT plus
LA - English
PY - 2017
SN - 1530-9932
SP - 494-508
ST - Characterization of Antimicrobial Agent Loaded Eudragit RS Solvent Exchange-
Induced In Situ Forming Gels for Periodontitis Treatment
TI - Characterization of Antimicrobial Agent Loaded Eudragit RS Solvent Exchange-
Induced In Situ Forming Gels for Periodontitis Treatment
VL - 18
ID - 13685
ER -
TY - JOUR
AB - Solvent-exchanged in situ forming gel is a drug delivery system which is in
sol form before administration. When it contacts with the body fluid, then the
water miscible organic solvent dissipates and water penetrates into the system,
leading the polymer precipitation as in situ gel at the site of injection. The aim
of this research was to study the parameters affecting the gel properties, drug
release and antimicrobial activities of the in situ forming gels prepared from
ethyl cellulose (EC) dissolved in N-methyl pyrrolidone (NMP) to deliver the
antimicrobial agents (doxycycline hyclate, metronidazole and benzyl peroxide) for
periodontitis treatment. The gel appearance, pH, viscosity, rheology,
syringeability, gel formation, rate of water diffusion into the gels, in vitro
degradation, drug release behavior and antimicrobial activities against
Staphylococcus aureus, Escherichia coli, Candida albicans, Streptococcus mutans and
Porphyrommonas gingivalis were determined. Increasing the amount of EC increased
the viscosity of system while still exhibiting Newtonian flow and increased the
work of syringeability whereas decreased the releasing of drug. The system
transformed into the rigid gel formation after being injected into the simulated
gingival crevicular fluid. The developed systems containing 5% w/w antimicrobial
agent showed the antimicrobial activities against all test bacteria. Thus the
developed solvent exchange-induced in situ forming gels comprising EC-antimicrobial
drugs exhibited potential use for periodontitis treatment.
AN - rayyan-563560372
AU - Phaechamud, T.
AU - Mahadlek, J.
DO - 10.1016/j.ijpharm.2015.08.047
IS - 1
benzoyl peroxide
doxycycline hyclate
ethyl cellulose
metronidazole
solvent
water
article
Candida albicans
diffusion
dissolution
drug degradation
drug release
Escherichia coli
flow kinetics
gel
in vitro study
periodontitis
pH
pH measurement
priority journal
viscosity
LA - English
PY - 2015
SN - ["1873-3476", "0378-5173"]
SP - 381-392
ST - Solvent exchange-induced in situ forming gel comprising ethyl cellulose-
antimicrobial drugs
T2 - Int. J. Pharm.
TI - Solvent exchange-induced in situ forming gel comprising ethyl cellulose-
antimicrobial drugs
VL - 494
ID - 13746
ER -
TY - JOUR
AN - rayyan-563561902
AU - Phaechamud, T.
AU - Mahadlek, J.
AU - Aroonrerk, N.
AU - Choopun, S.
DO - 10.2306/scienceasia1513-1874.2012.38.064
IS - 1
PY - 2012
SP - 64-74
ST - Antimicrobial activity of ZnO-doxycycline hyclate thermosensitive gel
T2 - ScienceAsia
TI - Antimicrobial activity of ZnO-doxycycline hyclate thermosensitive gel
84860636047&doi=10.2306%2fscienceasia1513-
1874.2012.38.064&partnerID=40&md5=527a235778975057925558e37d364901
VL - 38
ID - 15276
ER -
TY - JOUR
AB - To characterize the thermal behavior and texture analysis of doxycycline
hyclate thermosensitive gels developed for periodontitis treatment containing zinc
oxide prepared by using poloxamer (Lutrol ® F127) as polymeric material and N-
methyl pyrrolidone was used as cosolvent. The thermosensitive gel comprising
doxycycline hyclate, Lutrol® F127, and N-methyl pyrrolidone were characterized for
the thermal behavior and texture analysis. The topography of the system after the
dissolution test was characterized with scanning electron microscope. Differential
scanning calorimetric thermogram exhibited the endothermic peaks in the systems
containing high amount of N-methyl pyrrolidone in solvent. The sol-gel transition
temperature of the systems decreased as the zinc oxide amount was increased. The
addition of doxycycline hyclate, zinc oxide, and N-methyl pyrrolidone affected the
syringeability of systems. The addition of zinc oxide into the doxycycline hyclate-
Lutrol ® F127 systems decreased the diameter of inhibition zone against
Staphylococcus aureus, Escherichia coli, and Candida albicans since zinc oxide
decreased the diffusion and prolonged release of doxycycline hyclate. From scanning
electron microscope analysis, the porous surface of 20% w/w Lutrol® F127 system was
notably different from that of gel comprising doxycycline hyclate which had
interconnected pores and smooth surfaces. The number of pores was decreased with
increasing zinc oxide and the porous structure was smaller and more compact.
Therefore, the addition of zinc oxide could increase the syringeability of
doxycycline hyclate-Lutrol® F127 system with the temperature dependence. Zinc oxide
decreased inhibition zone against test microbes because of prolongation of
doxycycline hyclate release and reduced size of continuous cells. Furthermore, zinc
oxide also increased the compactness of wall surfaces of Lutrol® F127.
AN - rayyan-563560479
AU - Phaechamud, T.
AU - Mahadlek, J.
DO - 10.4103/0250-474X.119807
IS - 4
doxycycline hyclate
poloxamer
zinc oxide
antifungal activity
article
bacterial growth
Candida albicans
cell size
controlled study
drug diffusion
drug release
drug solubility
drug structure
Escherichia coli
fungus growth
gel
growth inhibition
heat sensitivity
nonhuman
periodontitis
porosity
surface property
thermography
topography
LA - English
PY - 2013
SN - ["0250-474X", "1998-3743"]
SP - 385-392
ST - Texture and topography analysis of doxycycline hyclate thermosensitive
systems comprising zinc oxide
T2 - Indian J. Pharm. Sci.
TI - Texture and topography analysis of doxycycline hyclate thermosensitive
systems comprising zinc oxide
VL - 75
ID - 13853
ER -
TY - JOUR
AN - rayyan-563561855
AU - Phaechamud, T.
AU - Mahadlek, J.
AU - Chuenbarn, T.
DO - 10.1016/j.matdes.2015.09.138
PY - 2016
SP - 294-303
ST - In situ forming gel comprising bleached shellac loaded with antimicrobial
drugs for periodontitis treatment
T2 - Materials and Design
TI - In situ forming gel comprising bleached shellac loaded with antimicrobial
drugs for periodontitis treatment
84947710373&doi=10.1016%2fj.matdes.2015.09.138&partnerID=40&md5=1804574b0cb9888e0fb
978ebb76dd1ef
VL - 89
ID - 15229
ER -
TY - JOUR
AB - Abstract: Antibiotic-loaded in situ forming gels are particularly attractive
for periodontitis treatment. They are in a sol form and gradually alter to a solid-
like depot after administration into a periodontal pocket to deliver and maintain
the effective high level of drug in the gingival crevicular fluid. Solvent-inducing
in situ forming gel mostly exhibits the burst drug release owing to rapid diffusion
of solvent. This study incorporated peppermint oil to modulate the drug release and
the gel characteristics of doxycycline hyclate-loaded Eudragit RS in situ forming
gel systems. Peppermint oil increased the viscosity and syringeability of the
Eudragit RS solution comprising NMP as solvent and retarded the water penetration.
Therefore the diminishment of burst liberation and the prolongation of drug release
with an addition of peppermint oil were attained with concentration dependence
mainly following Fickian diffusion mechanism. The drug release from the membrane-
less diffusion method was apparently slower than that from the dialysis method
because the rapid phase separation into solid-like matrix through a direct contact
with dissolution medium generated a hard surrounding shell. These solvent exchange-
inducing in situ forming gels comprising peppermint oil effectively inhibited
Staphylococcus aureus, Escherichia coli, Streptococcus mutans and Porphyrommonas
gingivalis; therefore, they exhibited the potential use as localized delivery
systems for periodontitis treatment.
AN - rayyan-563560248
AU - Phaechamud, T.
AU - Mahadlek, J.
DO - 10.1007/s40005-017-0340-x
IS - 4
eudragit
peppermint oil
article
drug release
Escherichia coli
human
nonhuman
periodontitis
priority journal
viscosity
water transport
LA - English
PY - 2018
SN - ["2093-6214", "2093-5552"]
SP - 451-464
ST - Peppermint oil/doxycycline hyclate-loaded Eudragit RS in situ forming gel for
TI - Peppermint oil/doxycycline hyclate-loaded Eudragit RS in situ forming gel for
VL - 48
ID - 13622
ER -
TY - JOUR
AB - Cholesterol has been widely used in drug delivery systems including implant.
Doxycycline hyclate (DH)-loaded cholesterol in situ forming gels using N-methyl
pyrrolidone as a solvent were prepared and investigated for their properties
including viscosity, rheology, syringeability, gel formation, drug release,
degradation and antimicrobial activities. The burst drug release of a DH-loaded in
situ forming gel using cholesterol as the gelling agent was minimized when the
amount of benzyl benzoate was increased. The viscosity of the system was increased
as the amount of benzyl benzoate was increased with Newtonian flow. The systems
were easy to inject into the target site because of their minimal force of
syringeability. They could transform from solution into matrix-like structures, but
formulations with higher concentrations of benzyl benzoate took a longer time.
However, the degradability was decreased when the amount of benzyl benzoate was
increased. These systems inhibited P. gingivalis, S. mutans and S. aureus
effectively. DH-loaded cholesterol in situ forming gel system comprising 10% benzyl
benzoate was the most suitable owing to its sustainable release manner for 10 days
and therefore was the proper formulation for periodontitis treatment.
AN - rayyan-563560307
AU - Phaechamud, T.
AU - Setthajindalert, O.
DO - 10.1016/j.ejps.2016.12.023
KW - benzyl benzoate
cholesterol
doxycycline hyclate
article
drug degradation
drug formulation
drug release
flow kinetics
force
gel
in vitro study
morphology
nonhuman
periodontitis
priority journal
shear stress
surface property
tooth implant
viscosity
LA - English
PY - 2017
SN - ["1879-0720", "0928-0987"]
SP - 258-265
ST - Cholesterol in situ forming gel loaded with doxycycline hyclate for intra-
periodontal pocket delivery
TI - Cholesterol in situ forming gel loaded with doxycycline hyclate for intra-
periodontal pocket delivery
VL - 99
ID - 13681
ER -
TY - JOUR
AB - N-methyl pyrrolidone (NMP), dimethyl sulfoxide (DMSO), 2-pyrrolidone (PYR)
and eutectic (1:1 menthol:camphor) were used as solvents for bleached shellac in
doxycycline hyclate (DH)-loaded in situ forming gel. The apparent viscosity,
rheology, syringeability, gel formation, degradability, drug release, and
antimicrobial activity against Staphylococcus aureus, Streptococcus mutans and
Porphyromonas gingivalis were investigated. DH loaded in-situ forming gels
exhibited Newtonian or pseudoplastic flow and were able to be injected, and formed
a gel after contact with simulated crevicular fluid. They inhibited S. aureus, S.
mutans and P. gingivalis effectively. Fast diffusion of DMSO and NMP promoted the
formation of a bleached shellac scaffold with an apparent burst DH release which
initially occurred. DH-loaded in-situ forming gel containing bleached shellac using
PYR as the solvent presented itself as the most appropriate preparation for
periodontitis treatment because it sustained drug release and exhibited suitable
degradation.
AN - rayyan-563560244
AU - Phaechamud, T.
AU - Setthajindalert, O.
DO - 10.1016/j.jddst.2018.05.035
2 pyrrolidinone
dimethyl sulfoxide
doxycycline hyclate
eutectic (1:1 menthol:camphor)
shellac
solvent
unclassified drug
article
bleaching
drug degradation
drug release
drug synthesis
flow kinetics
gel
nonhuman
periodontitis
solvent effect
viscosity
LA - English
PY - 2018
SN - 1773-2247
SP - 285-293
ST - Antimicrobial in-situ forming gels based on bleached shellac and different
solvents
TI - Antimicrobial in-situ forming gels based on bleached shellac and different
solvents
VL - 46
ID - 13618
ER -
TY - JOUR
AB - Solvent exchange induced in situ forming gel (ISG) is the promising drug
delivery system for periodontitis treatment owing to the prospect of maintaining an
effective high drug level in the gingival crevicular fluid. In the present study,
the influence of clove oil (CO) on the characteristics of doxycycline hyclate (DH)-
loaded ISG comprising Eudragit RS (ERS) was investigated including
viscosity/rheology, syringeability, in vitro gel formation/drug release, matrix
formation/solvent diffusion and antimicrobial activities. CO could dissolve ERS and
increase the viscosity of ISG and its hydrophobicity could also retard the
diffusion of solvent and hinder the drug diffusion; thus, the minimization of burst
effect and sustained drug release were achieved effectively. All the prepared ISGs
comprising CO could expel through the 27-gauge needle for administration by
injection and transform into matrix depot after exposure to the simulated gingival
crevicular fluid. The antimicrobial activities against Staphylococcus aureus,
Escherichia coli, Streptococcus mutans and Porphyromonas gingivalis were increased
when the ratio of CO and N-methyl pyrrolidone (NMP) was decreased from 1:1 to 1:10
owing to higher diffusion of DH except that for C. albicans was increased as CO
amount was higher. Therefore, CO could minimize the burst while prolonging the drug
release of DH-loaded ERS ISG for use as a local drug delivery system for
AN - rayyan-563560261
AU - Phaechamud, T.
AU - Thurein, S. M.
AU - Chantadee, T.
DO - 10.1016/j.ajps.2017.09.004
IS - 2
clove oil
doxycycline hyclate
eudragit rs
article
comparative study
controlled study
drug diffusion
drug solubility
Escherichia coli
flow kinetics
human
hydrogel
hydrophobicity
in vitro study
periodontitis
phase separation
shear stress
solvent extraction
surface property
viscosity
LA - English
PY - 2018
SN - ["2221-285X", "1818-0876"]
SP - 131-142
ST - Role of clove oil in solvent exchange-induced doxycycline hyclate-loaded
Eudragit RS in situ forming gel
T2 - Asian J. Pharm. Sci.
TI - Role of clove oil in solvent exchange-induced doxycycline hyclate-loaded
Eudragit RS in situ forming gel
VL - 13
ID - 13635
ER -
TY - JOUR
AB - Objectives: Periodontal treatment focuses on the thorough removal of specific
periodontal pathogens, mainly anaerobic Gram-negative bacteria, by mechanical
scaling and root planning. In case the periodontal abscess is detected after
treatment, a high dose of antimicrobial agents is commonly applied via oral
administration. However, this approach increases the risk of antibiotic resistance
and systemic side effects and decreases efficacy. To overcome the aforementioned
issues, this study focused on the development of thermosensitive hydrogel to
deliver the antibiotic drug metronidazole (MTZ) directly and locally to the oral
infection site. Materials and Methods: The thermosensitive hydrogels were prepared
by blending 28% w/v Pluronic F127 with various concentrations of methylcellulose
(MC) and silk fibroin (SF). The gel properties, such as sol-gel transition time,
viscosity, and gel strength, were investigated. The drug dissolution profiles,
together with their theoretical models and gel dissolution characteristics, were
also determined. Results: All hydrogel formulations exhibited sol-gel transitions
at 37°C within 1 min. An increase in MC content proportionally increased the
viscosity but decreased the gel strength of the hydrogel. By contrast, the SF
content did not significantly affect the viscosity but increased the gel strength
of the hydrogel. The thermosensitive hydrogels also showed prolonged MTZ release
characteristics for 10 days in phosphate-buffered saline (PBS) at pH 6.6, which
followed the Higuchi diffusion model. Moreover, MTZ-thermosensitive hydrogel
exhibited delayed dissolution in PBS at 37°C for more than 9 days. Conclusion: MTZ-
thermosensitive hydrogels could be considered a prospective local oral drug
delivery system to achieve efficient sustained release and improve the drug
pharmacological properties in periodontitis treatment.
AN - rayyan-563560045
AU - Pham, D. T.
AU - Phewchan, P.
AU - Navesit, K.
AU - Chokamonsirikun, A.
AU - Khemwong, T.
AU - Tiyaboonchai, W.
DO - 10.4274/tjps.galenos.2020.09623
IS - 4
hydrogel
methylcellulose
metronidazole
silk fibroin
article
cocoon
controlled study
critical micelle concentration
drug release
drug solubility
heat sensitivity
mouth infection
nonhuman
periodontitis
sol-gel
storage temperature
tablet property
LA - English
PY - 2021
SN - 1304-530X
SP - 510-516
ST - Development of metronidazole-loaded in situ thermosensitive hydrogel for
T2 - Periodontit tedavisi için metronidazol yüklü yerinde termosensitif hidrojel
geliştirilmesi
TI - Development of metronidazole-loaded in situ thermosensitive hydrogel for
VL - 18
ID - 13419
ER -
TY - JOUR
AB - BACKGROUND: Local drug delivery agents can effectively deliver the
antimicrobial drugs in bactericidal concentration, and have shown improved clinical
outcomes when used as an adjunct to mechanical therapy. The aim of this study was
to evaluate the efficacy of a xanthan-based chlorhexidine gel versus herbal
extracts' gel as an adjunct to periodontal therapy in the treatment of chronic
periodontitis. MATERIALS AND METHODS: A total of 150 sites, age group of 30-50
years, periodontal pockets measuring 5-8 mm and diagnosed with chronic
periodontitis were selected for the study. The selected sites were randomized in
five groups: Scaling and root planing (SRP) alone (Group A), SRP + Chlosite gel
(Group B), SRP + Herbal gel (Group C), Chlosite gel alone (Group D) and Herbal gel
alone (Group E). Clinical parameters such as Plaque Index, Gingival Index, probing
pocket depth and clinical attachment level were recorded at baseline and 1- and 3-
month intervals. RESULTS: After 3 months, there were statistically significant
reductions in all the clinical parameters for Groups B and C compared with Group A.
There was no significant reduction in all clinical parameters between Group D and E
where no mechanical therapy was performed. CONCLUSION: The results indicate that
the local application of herbal gel can be comparably used as chlorhexidine gel in
the treatment of chronic periodontitis as an adjunct to mechanical periodontal
therapy.
AN - rayyan-563560973
AU - Phogat, M.
AU - Rana, T.
AU - Prasad, N.
AU - Baiju, C. S.
DO - 10.4103/0972-124X.131319
IS - 2
LA - eng
N1 - Department of Periodontics, Seema Dental College and Hospital, Rishikesh,
Haryana, India.; Department of Orthodontics, Seema Dental College and Hospital,
Rishikesh, Haryana, India.; Department of Orthodontics, Seema Dental College and
Hospital, Rishikesh, Haryana, India.; Department of Periodontics, Sudha Rustogi
College of Dental Sciences, Faridabad, Haryana, India.
PY - 2014
SN - 0972-124X (Print)
SP - 172-7
ST - Comparative evaluation of subgingivally delivered xanthan-based chlorhexidine
gel and herbal extract gel in the treatment of chronic periodontitis
TI - Comparative evaluation of subgingivally delivered xanthan-based chlorhexidine
gel and herbal extract gel in the treatment of chronic periodontitis
VL - 18
Y2 - 3
ID - 14347
ER -
TY - JOUR
AB - The aim of this study was to evaluate the clinical and bacteriological
effects of the intrasulcular application of a 1% metronidazole-gel (repeated
administrations outdistanced of 7 days weeks long) currently employed in
dermatological practice, to observe if a lower concentration of the chemotherapic
agent could be equally effective as the 25% formulation in improving the
periodontal condition of nine patients with adult periodontitis. The results showed
that this regimen can modify, at a statistically significant level, the clinical
(Pocket Probing Depth, Gingival Bleeding Index and Plaque Index) and
bacteriological (Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis,
Prevotella intermedia and Veillonella parvula) parameters associated with adult
periodontitis. The results are similar to those obtainable with a 25%
Metronidazole-gel administered two times outdistanced by 7 days.
AN - rayyan-563561005
AU - Catamo, G.
AU - Di Placido, G.
AU - D'Ercole, S.
AU - Tumini, V.
AU - Picciani, C.
IS - 3
KW - metronidazole
adult
article
clinical trial
female
follow up
gel
gingiva bleeding
human
male
microbiology
middle aged
periodontics
periodontitis
tooth plaque
LA - English
PY - 1999
SN - 1121-7138
SP - 219-225
ST - Bacteriological and clinical follow-up of periodontal pockets during a
topically applied 1% metronidazole-gel therapy in patients with adult periodontitis
T2 - New Microbiol.
TI - Bacteriological and clinical follow-up of periodontal pockets during a
topically applied 1% metronidazole-gel therapy in patients with adult periodontitis
VL - 22
ID - 14379
ER -
TY - JOUR
AB - The aim of this study was to report the microbiological and clinical effects
of repeated subgingival administration of a 1% Chlorhexidine-gel in periodontal
pockets from 10 patients with adult periodontitis. Results showed that the
experimental treatment significantly improved clinical parameters (Plaque Index,
Gingival Bleeding Index, and Pocket Probing Depth). Direct subgingival
administration of Chlorhexidine-gel also produced a remarkable modification in the
proportions of putative periodontopathic microorganisms, such as Actinobacillus
actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Veillonella
parvula, Fusobacterium nucleatum, and Peptostreptococcus micros, in subgingival
bacterial plaque from periodontitis patients.
AN - rayyan-563561009
AU - Di Bonaventura, G.
AU - Catamo, G.
AU - Tumini, V.
AU - Di Placido, G.
AU - D'Ercole, S.
AU - Perfetti, G.
IS - 2
KW - chlorhexidine
Actinobacillus
adult
article
bacterium
classification
clinical trial
female
gingiva
Gram negative anaerobic bacteria
human
male
microbiology
middle aged
Peptostreptococcus
periodontitis
tooth plaque
LA - English
PY - 1999
SN - 1121-7138
SP - 111-116
ST - Microbiological and clinical effects of a 1% chlorhexidine-gel in untreated
periodontal pockets from adult periodontitis patients
T2 - New Microbiol.
TI - Microbiological and clinical effects of a 1% chlorhexidine-gel in untreated
periodontal pockets from adult periodontitis patients
VL - 22
ID - 14383
ER -
TY - JOUR
AB - The aims of this study were to find the optimal formulation for the
preparation of metronidazole-loaded chitosan microparticles (MTZ-MPs) via an
emulsion cross-linking process, and to compare the in vitro release of MTZ from
hydrogels and films containing the drug in forms of MTZ-MPs and raw powders. The
effects of emulsifier type and concentration, amount of cross-linking agent, cross-
linking time, drug:chitosan ratio, form of drug adding and washing method on the
properties of the MTZ-MPs were investigated. The results indicated that the optimal
conditions for round and free-flowing MTZ-MPs with a high percentage of entrapped
drug and preferable release profile were 1% of Span80 in soybean oil, 5% of
glutaraldehyde based on chitosan solution, 30 min of cross-linking time, 1:1
drug:chitosan ratio, drug adding in form of ethanol solution and washing with
hexane only. MTZ-MPs prepared from the optimal formulation were incorporated in
mucoadhesive hydrogel and film. The release profiles of the drug from hydrogel and
film containing MTZ-MPs were in prolong pattern compared with those containing drug
powders. However, the hydrogels exhibited higher preferable pattern of release
profile than the films. Therefore, the hydrogel containing MTZ-MPs was possible to
be further clinically investigated for peridontitis treatment. Copyright © 2012
Elsevier B.V. All rights reserved.
AN - rayyan-563560488
AU - Boonme, P.
IS - 3
KW - chitosan
glutaraldehyde
metronidazole
microsphere
article
chemistry
emulsion
Films
hydrogel
Microparticles
periodontitis
LA - English
PY - 2013
SN - 1873-0191
SP - 1197-1202
ST - Evaluation of cross-linked chitosan microparticles containing metronidazole
TI - Evaluation of cross-linked chitosan microparticles containing metronidazole
VL - 33
ID - 13862
ER -
TY - JOUR
AB - This study aimed to evaluate the effects of a new photodynamic protocol
(ALAD-PDT) on primary human osteoblasts (hOBs). The ALAD-PDT protocol consists of a
heat-sensitive gel with 5% 5-delta aminolevulinic acid commercialized as Aladent
(ALAD), combined with 630 nm LED. For this purpose, the hOBs, explanted from human
mandible bone fragments, were used and treated with different ALAD concentrations
(10%, 50%, 100% v/v) incubated for 45 min and immediately afterwards irradiated
with a 630 nm LED device for 7 min. The untreated and unirradiated cells were
considered control (CTRL). The cellular accumulation of the photosensitizer
protoporphyrin IX (PpIX), the proliferation, the alkaline phosphatase (ALP)
activity, and the calcium deposition were assessed. All concentrations (10, 50,
100%) determined a significant increment of PpIX immediately after 45 min of
incubation (0 h) with the highest peak by ALAD (100%). The consequent 7 min of
light irradiation caused a slight decrease in PpIX. At 48 h and 72 h, any increment
of PpIX was observed. The concentration 100% associated with LED significantly
increased hOB proliferation at 48 h (+46.83%) and 72 h (+127.75%). The 50% and 100%
concentrations in combination to the red light also stimulated the ALP activity,
+12.910% and +14.014% respectively. The concentration 100% with and without LED was
selected for the assessment of calcium deposition. After LED irradiation, a
significant increase in calcium deposition was observed and quantified (+72.33%).
In conclusion, the ALAD-PDT enhanced proliferation, the ALP activity, and
mineralized deposition of human oral osteoblasts, highlighting a promising
potential for bone tissue regeneration.
AN - rayyan-563562545
AU - D'Amico, E.
AU - Iezzi, G.
AU - Petrini, M.
AU - Schiavone, V.
AU - Santalucia, M.
AU - Pandolfi, A.
AU - D'Arcangelo, C.
AU - Piattelli, A.
AU - Di Pietro, N.
DO - 10.1007/s10103-022-03651-8
IS - 9
PY - 2022
SN - ["0268-8921", "1435-604X"]
SP - 3671-3679
ST - Effect of a 5-aminolevulinic acid gel and 660 nm red LED light on human oral
osteoblasts: a preliminary in vitro study
T2 - LASERS IN MEDICAL SCIENCE
TI - Effect of a 5-aminolevulinic acid gel and 660 nm red LED light on human oral
osteoblasts: a preliminary in vitro study
VL - 37
Y2 - 12
ID - 15919
ER -
TY - JOUR
AB - This study aimed to evaluate the effects of a new photodynamic protocol
(ALAD-PDT), consisting of 5% 5-aminolevulinic acid-gel and 630 nm-LED, already used
for antibacterial effects in the treatment of periodontitis, on human gingival
fibroblasts (HGF) and primary human osteoblasts (HOB). HGF and HOB were incubated
with different ALAD concentrations for 45 min, and subsequently irradiated with 630
nm-LED for 7 min. Firstly, the cytotoxicity at 24 h and proliferation at 48 and 72
h were assessed. Then the intracellular content of the protoporphyrin IX (PpIX) of
the ROS and the superoxide dismutase (SOD) activity were investigated at different
times. Each result was compared with untreated and unirradiated cells as the
control. Viable and metabolic active cells were revealed at any concentrations of
ALAD-PDT, but only 100-ALAD-PDT significantly enhanced the proliferation rate. The
PpIX fluorescence significantly increased after the addition of 100-ALAD, and
decreased after the irradiation. Higher ROS generation was detected at 10 min in
HGF, and at 30 min in HOB. The activity of the SOD enzyme augmented at 30 min in
both cell types. In conclusion, ALAD-PDT not only showed no cytotoxic effects, but
had pro-proliferative effects on HGF and HOB, probably via ROS generation.
AN - rayyan-563560964
AU - D'Amico, E.
AU - Petrini, M.
AU - Pandolfi, A.
AU - D'Arcangelo, C.
AU - Di Pietro, N.
AU - Piattelli, A.
AU - Iezzi, G.
DO - 10.3390/gels8080491
IS - 8
J2 - Gels
LA - eng
N1 - Department of Medical, Oral and Biotechnological Sciences, University G.
d'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.; Department of Medical, Oral and
Biotechnological Sciences, University G. d'Annunzio of Chieti-Pescara, 66100
Chieti, Italy.; Department of Medical, Oral and Biotechnological Sciences,
Pescara, 66100 Chieti, Italy.; Center for Advanced Studies and Technology-CAST,
Pescara, 66100 Chieti, Italy.; Department of Medical, Oral and Biotechnological
Sciences, University G. d'Annunzio of Chieti-Pescara, 66100 Chieti, Italy.; Center
for Advanced Studies and Technology-CAST, University G. d'Annunzio of Chieti-
Pescara, 66100 Chieti, Italy.; School of Dentistry, Saint Camillus International
University of Health and Medical Sciences, Via di Sant'Alessandro 8, 00131 Rome,
Italy.; Dental School, University of Belgrade, 11000 Belgrade, Serbia.; Fondazione
Villa Serena per la Ricerca, 65013 Città Sant'Angelo, Italy.; Casa di Cura Villa
Serena del Dott. L. Petruzzi, 65013 Città Sant'Angelo, Italy.; Department of
Pescara, 66100 Chieti, Italy.
PY - 2022
ST - The Effects of 5% 5-Aminolevulinic Acid Gel and Red Light (ALAD-PDT) on Human
Fibroblasts and Osteoblasts
TI - The Effects of 5% 5-Aminolevulinic Acid Gel and Red Light (ALAD-PDT) on Human
VL - 8
Y2 - 8 y3 - 8
ID - 14338
ER -
TY - JOUR
AN - rayyan-563561649
AU - D’Amico, E.
AU - Petrini, M.
AU - Pandolfi, A.
AU - D’Arcangelo, C.
AU - Di Pietro, N.
AU - Piattelli, A.
AU - Iezzi, G.
DO - 10.3390/gels8080491
IS - 8
PY - 2022
ST - The Effects of 5% 5-Aminolevulinic Acid Gel and Red Light (ALAD-PDT) on Human
T2 - Gels
TI - The Effects of 5% 5-Aminolevulinic Acid Gel and Red Light (ALAD-PDT) on Human
85137397636&doi=10.3390%2fgels8080491&partnerID=40&md5=4640604ca7d75a0ae65833e9c428
2605
VL - 8
ID - 15023
ER -
TY - JOUR
AB - The copaiba oil (Copaifera officinalis) potential was evaluated in preventing
periodontal disease and reducing its etiology. For that 18 mongrel dogs were
homogeneously distributed in three groups: test (copaiba oil), positive control
(chlorexidine) and negative control. The treatments were carried out three times a
day, during eight days. On the 9(th) day, the animals were tested with a 0.5% basic
solution of fuchsin for the detection of biofilm. Changes in halitosis and
gingivitis were daily observed. In addition, the following laboratory tests were
done: inhibition of the adherence of Streptococcus mutans, and plaque forming
bacteria antimicrobial assays by the agar diffusion method. The results of the
fuchsin test showed that dental plaque reached areas of 53.4 +/- 8.8%, 28.5 +/-
5.4%, and 22.3 +/- 5.3% in the negative control, positive control, and test groups,
respectively, showing differences between dogs from the negative control group and
dogs from the other two groups (P<0.05). Furthermore, halitosis and gingivitis
decreased in the copaiba group animals when compared with the negative group
(P<0.05). The results of the attachment inhibition and agar diffusion tests showed
that copaiba induced better effects against the microorganisms as compared to the
results of the other groups (P<0.05). These findings suggest that copaiba oil may
effectively replace chlorexidine for oral antimicrobial therapy and prevention of
AN - rayyan-563562578
AU - Pieri, F. A.
AU - Mussi, M. C.
AU - Fiorini, J. E.
AU - Schneedorf, J. M.
DO - 10.1590/S0102-09352010000300012
IS - 3
PY - 2010
SN - 0102-0935
SP - 578-585
ST - Clinical and microbiological effects of copaiba oil (Copaifera officinalis)
on dental plaque forming bacteria in dogs
T2 - ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA
TI - Clinical and microbiological effects of copaiba oil (Copaifera officinalis)
on dental plaque forming bacteria in dogs
VL - 62
Y2 - 6
ID - 15952
ER -
TY - JOUR
AB - BACKGROUND: In the present study, the antimicrobial properties of a new
ozonized olive oil (O-zone gel) against oral and periodontal pathogens will be
evaluated and compared with that of common CHX-based agents. MATERIAL AND METHODS:
O-zone gel was compared with two agents based on chlorhexidine digluconate (CHX):
Corsodyl Dental Gel and Plak Gel. A. actinomycetemcomitans, P. intermedia and S.
mutans, were selected and the antibacterial capability of the compounds was tested
by using direct contact agar diffusion test (DCT) and minimum inhibitory
concentration (MIC) and minimum bactericidal concentration (MBC) evaluations.
Differences between specific means were analyzed by a one-way analysis of variance
(ANOVA). Group means were compared using a one-way ANOVA and Tukey's test (P<0.05).
RESULTS: O-zone gel reported inhibition zones which correspond to 33% and 43% of
that achieved by the CHX agents. No inhibition of bacterial growth (MIC) on the
Gram-positive strain by using O-zone gel was found and no antimicrobial effect
(MBC) was observed by using O-zone gel on both Gram-negative and -positive strains.
CONCLUSIONS: The new ozonated oil was a relatively moderate antiseptic. Gram-
negative bacteria proved to be more sensitive to ozonized olive oil than Gram-
positive ones. The ozonized olive oil demonstrated a lower antibacterial activity
if compared to the CHX-based agents tested. Key words:Agar diffusion test,
antibacterial activity, direct contact test, ozone, ozonized olive oil.
AN - rayyan-563560946
AU - Pietrocola, G.
AU - Ceci, M.
AU - Preda, F.
AU - Poggio, C.
AU - Colombo, M.
DO - 10.4317/jced.54929
IS - 11
J2 - J Clin Exp Dent
LA - eng
N1 - Department of Molecular Medicine, Unit of Biochemistry, University of Pavia,
Pavia, Italy.; Department of Clinical-Surgical, Diagnostic and Pediatric Sciences -
Section of Dentistry, University of Pavia, Pavia, Italy.; Department of Clinical-
Surgical, Diagnostic and Pediatric Sciences - Section of Dentistry, University of
Pavia, Pavia, Italy.; Department of Clinical-Surgical, Diagnostic and Pediatric
Sciences - Section of Dentistry, University of Pavia, Pavia, Italy.; Department of
Clinical-Surgical, Diagnostic and Pediatric Sciences - Section of Dentistry,
University of Pavia, Pavia, Italy.
PY - 2018
SN - 1989-5488 (Print)
SP - e1103-e1108
ST - Evaluation of the antibacterial activity of a new ozonized olive oil against
oral and periodontal pathogens
T2 - Journal of clinical and experimental dentistry
TI - Evaluation of the antibacterial activity of a new ozonized olive oil against
oral and periodontal pathogens
VL - 10
Y2 - 11
ID - 14320
ER -
TY - JOUR
AB - PURPOSE: Chlorhexidine gluconate is a relatively commonly used
chemotherapeutic in the treatment of periodontitis (P), exhibiting antimicrobial
capabilities against Gram-negative and Gram-positive bacteria, and fungi. This
compound is a component of various preparations for topical use in the form of
solutions for mouthrinsing or peri-irrigation, gels, varnishes, chips and even
chewing gums. The aim of the study was the clinical evaluation of periodontium
after treatment with one of the drugs containing chlorhexidine gluconate (Corsodyl)
as compared to professional tooth cleaning in patients with chronic periodontitis.
MATERAL AND METHODS: Forty subjects enrolled in the study were divided into four
groups, 10 in each group, according to the mode of treatment (Corsodyl rinse,
Corsodyl gel, Corsodyl gel + surgical dressing, scaling). RESULTS: The greatest
differences between baseline and follow-up examinations were observed in the group
where surgical dressing was applied in addition to Corsodyl gel and in the group
treated with scaling. CONCLUSIONS: Chlorhexidine gluconate should be more
frequently used as a drug adjunct to classic periodontal therapy, especially in the
forms allowing its direct application to the periodontal pockets.
AN - rayyan-563560755
AU - Pietruska, M.
AU - Paniczko, A.
AU - Waszkiel, D.
AU - Pietruski, J.
AU - Bernaczyk, A.
KW - chlorhexidine
drug derivative
adult
aged
article
chronic disease
clinical trial
controlled study
drug effect
female
human
male
middle aged
mouth hygiene
periodontitis
periodontium
treatment outcome
LA - English
PY - 2006
SN - 1896-1126
SP - 162-165
ST - Efficacy of local treatment with chlorhexidine gluconate drugs on the
clinical status of periodontium in chronic periodontitis patients
T2 - Adv Med Sci
TI - Efficacy of local treatment with chlorhexidine gluconate drugs on the
clinical status of periodontium in chronic periodontitis patients
VL - 51
ID - 14129
ER -
TY - JOUR
AB - Blood derivates, such as platelet-rich plasma (PRP) and platelet-rich fibrin
(PRF), are autogenous sources of many growth factors that are involved in the
healing and regeneration of tissues, and for this reason, are used in dentistry
treatments. This fact also contributes to the growing interest in these
biomaterials in regenerative personalized medicine. The multitude of platelet-rich
forms creates many possibilities for their use. This semi-systematic review
describes and compares the methods of obtaining properties and potential uses of
these materials in personalized treatments.
AN - rayyan-563562620
AU - Pietruszka, P.
AU - Chruscicka, I.
AU - Dus-Ilnicka, I.
AU - Paradowska-Stolarz, A.
DO - 10.3390/jpm11100944
IS - 10
PY - 2021
SN - 2075-4426
ST - PRP and PRF-Subgroups and Divisions When Used in Dentistry
T2 - JOURNAL OF PERSONALIZED MEDICINE
TI - PRP and PRF-Subgroups and Divisions When Used in Dentistry
VL - 11
Y2 - 10
ID - 15994
ER -
TY - JOUR
AB - Background: The aim of this study was to evaluate the microhardness and
quantify the presence of minerals (Calcium and Phosphorous) of tooth enamel
submitted to bleaching with violet LED light, either associated with 35% hydrogen
peroxide gel, or not. Methods: Bovine incisors were selected and divided into 4
Groups according to the bleaching technique used: C- Without bleaching (Control);
VL- violet LED; HP- 35% Hydrogen Peroxide; HP+VL- 35% Hydrogen Peroxide + violet
LED. The response variables were surface microhardness (n = 12), Energy Dispersive
Spectroscopy (EDS) (n = 6) and scanning electron microscopy (SEM) (n = 3). Results:
The 2-way ANOVA test with repeated measures showed that there was difference in the
microhardness values of enamel in the specimens in all of the Groups when the
values measured in the initial and final time intervals were compared, however,
without significant differences between the values of the different treatments in
both time intervals. The results with reference to EDS were analyzed with the 1-way
ANOVA test. There was difference among the Groups only in the Ca%, with Group HP
obtaining the lowest values, with significant difference from those of the C Group.
SEM images showed a smooth, homogeneous enamel surface and similarity among the
Groups, irrespective of the treatment performed. Conclusions: Therefore, it was
concluded that the changes caused in enamel by the use of violet LED Light, either
associated with 35% hydrogen peroxide, or not, did not differ from those of non-
bleached tooth enamel, showing absence of harm to the mineral content of tooth
enamel resulting from the use of violet LED.
AN - rayyan-563559833
AU - Pin, W. F.
AU - Benati, M. R. D. L.
AU - Souza, A. G. C. D.
AU - Ferraz, L. N.
AU - Vitti, R. P.
AU - Scatolin, R. S.
DO - 10.1016/j.pdpdt.2022.102852
KW - dental light
periodontal curette
protective equipment
calcium
hydrogen peroxide
phosphorus
animal tissue
article
controlled study
dental procedure
enamel
incisor
microhardness
nonhuman
LA - English
PY - 2022
SN - ["1873-1597", "1572-1000"]
ST - Evaluation of mineral content of tooth enamel after application violet led
associated with 35% hydrogen peroxide
TI - Evaluation of mineral content of tooth enamel after application violet led
associated with 35% hydrogen peroxide
VL - 38
ID - 13207
ER -
TY - JOUR
AB - In recent years, nanogels have emerged as promising drug delivery vehicles;
their ability in holding active molecules, macromolecules and drugs, together with
the capability to respond to external stimuli, makes them a suitable tool for a
wide range of applications. These features allow nanogels to be exploited against
many challenges of nanomedicine associated with different kinds of pathologies
which require the use of specific drug delivery systems. In this review our aim is
to give the reader an overview of the diseases that can be treated with nanogels as
drug delivery systems, such as cancer, CNS disorders, cardiovascular diseases,
wound healing and other diseases of human body. For all of these pathologies,
biological in vivo assays can be found in the literature and in this work. We focus
on the peculiarities of these nanogels, highlighting their features and their
advantages in respect to conventional treatments.
AN - rayyan-563560077
AU - Pinelli, F.
AU - Ortolà, Ó F.
AU - Makvandi, P.
AU - Perale, G.
AU - Rossi, F.
DO - 10.2217/nnm-2020-0274
IS - 27
KW - baicalin
bosentan
bupivacaine
chlorhexidine acetate
clobetasol
curcumin
cyclosporine
deferoxamine
doxorubicin
flurbiprofen
interferon regulatory factor 5
interleukin 12
isoniazid
methotrexate
minocycline
nanogel
naproxen
paclitaxel
plerixafor
prednisolone
prostaglandin E2
retinoid
rifampicin
rolipram
sulfadiazine silver
tannin
triclosan
urokinase
bioassay
bone regeneration
brain ischemia
breast cancer
central nervous system disease
edema
hemochromatosis
human
hypertension
in vivo study
malignant neoplasm
nanofabrication
nonhuman
osteosarcoma
periodontitis
peritonitis
priority journal
psoriasis
review
spinal cord injury
tuberculosis
ulcerative colitis
wound healing
amd 3100
LA - English
PY - 2020
SN - ["1748-6963", "1743-5889"]
SP - 2707-2727
ST - In vivo drug delivery applications of nanogels: A review
T2 - Nanomedicine
TI - In vivo drug delivery applications of nanogels: A review
VL - 15
ID - 13451
ER -
TY - JOUR
AB - OBJECTIVES: The purpose of this study is to evaluate the activity of two
different taurolidine (TAU) gels in comparison with a 0.2% chlorhexidine (CHX) gel
on an ex vivo subgingival biofilm. MATERIAL AND METHODS: Subgingival including
supragingival biofilm samples from periodontitis patients were cultured for 10
days, before TAU 1% and TAU 3% gels and CHX gel were applied for 10 min and
thereafter diluted with nutrient media to 10% for 50 min. One third of the samples
were analyzed for bacterial counts, biofilm quantity, and biofilm metabolic
activity. In the two other thirds, 90% of the nutrient media were replaced and
biofilms were incubated for 23 h. The second third was analyzed in the same way as
before. In the third part, patients' microorganisms were added again and incubated
for additional 24 h to allow reformation of biofilm before proceeding to analysis.
RESULTS: Decrease of bacterial counts in biofilms was highest following application
of TAU 3% after 60 min (0.87 log10 cfu, corresponding 86.5%), 24 and 48 h
(reformation of biofilms), respectively. All antimicrobials reduced biofilm
quantity after 24 h (each p < 0.05) and following reformation of biofilms (each p <
0.01). Metabolic activity in biofilms was decreased at 60 min (each p < 0.05) and
at 24 h (each p < 0.01) after application of TAU gels, while the activity of the
reformed biofilm was lower after application of all evaluated antimicrobials (each
p < 0.01) than in the control group (e.g., without exposure to antimicrobials).
CONCLUSION: The antimicrobial activity of taurolidine gels clearly depends on its
taurolidine concentration. A high concentrated taurolidine gel is equally active or
even superior to 0.2% chlorhexidine gel. However, the activity of antimicrobials is
limited in a complex established biofilm and underlines the pivotal role of
mechanical biofilm disruption. CLINICAL RELEVANCE: Within their limits, the data
suggest that TAU 3% gel might represent a potential alternative to 0.2%
chlorhexidine gel.
AN - rayyan-563560256
AU - Pirracchio, L.
AU - Joos, A.
AU - Luder, N.
AU - Sculean, A.
AU - Eick, S.
DO - 10.1007/s00784-017-2297-6
IS - 5
KW - chlorhexidine
taurine
taurolidine
thiadiazine derivative
bacterial load
biofilm
drug effect
gel
human
in vitro study
microbiology
periodontitis
treatment outcome
LA - English
PY - 2018
SN - 1436-3771
SP - 2031-2037
ST - Activity of taurolidine gels on ex vivo periodontal biofilm
TI - Activity of taurolidine gels on ex vivo periodontal biofilm
VL - 22
ID - 13630
ER -
TY - JOUR
AB - Background: Various types of oral tumors, either benign or malignant, are
commonly found in dogs. Since saliva directly contacts the tumors and saliva
collection is non-invasive, easily accessible and cost effective, salivary
biomarkers are practical to be used for the diagnosis and/or prognosis of these
diseases. However, there is limited knowledge of protein expression in saliva for
canine oral tumors. The present study aimed to investigate novel biomarkers from
the salivary proteome of dogs with early- and late-stage oral melanoma (EOM and
LOM, respectively), oral squamous cell carcinoma (OSCC), benign oral tumors (BN),
and periodontitis and healthy controls (CP), using an in-gel digestion coupled with
mass spectrometry (GeLC-MS/MS). The relationships between protein candidates and
chemotherapy drugs were explored and the expression of potential biomarkers in
saliva and tissues was verified by western blot analysis. Results: For saliva
samples, increased expression of protein tyrosine phosphatase non-receptor type 5
(PTPN5) was shown in all tumor groups compared with the CP group. Marked expression
of PTPN5 was also observed in LOM and OSCC compared with that in BN and EOM. In
addition, tumor protein p53 (p53), which appeared in the PTPN5-drug interactions,
was exhibited to be expressed in all tumor groups compared with that in the CP
group. For tissue samples, increased expression of p53 was shown in LOM compared
with the control group. Conclusion: PTPN5 and p53 were proposed to be potential
salivary biomarkers of canine oral tumors.
AN - rayyan-563560092
AU - Ploypetch, S.
AU - Roytrakul, S.
AU - Phaonakrop, N.
AU - Kittisenachai, S.
AU - Leetanasaksakul, K.
AU - Pisamai, S.
AU - Kalpravidh, C.
AU - Rungsipipat, A.
AU - Suriyaphol, G.
DO - 10.1186/s12917-020-02550-w
IS - 1
cisplatin
cyclin A
cyclin dependent kinase inhibitor 1A
cyclophosphamide
doxorubicin
histone acetyltransferase
protein kinase
protein p53
protein tyrosine phosphatase
saliva protein
article
ataxia telangiectasia
cancer growth
comparative study
controlled study
dog disease
drug interaction
gene overexpression
in gel digestion coupled with mass spectrometry
mass spectrometry
mouth tumor
nonhuman
periodontitis
protein degradation
protein expression
protein fingerprinting
Western blotting
LA - English
PY - 2020
SN - 1746-6148
ST - In-gel digestion coupled with mass spectrometry (GeLC-MS/MS)-based salivary
proteomic profiling of canine oral tumors
T2 - BMC Vet. Res.
TI - In-gel digestion coupled with mass spectrometry (GeLC-MS/MS)-based salivary
proteomic profiling of canine oral tumors
VL - 16
ID - 13466
ER -
TY - JOUR
AB - The properties of polyvinyl alcohol (PVA), such as the ability to form
membranes, good relative bioadhesiveness, the ability to mix with other polymers,
biodegradability, swelling in water, lead to an assumption that the polymer may be
used effectively as a carrier of the active substance onto the mucous membranes,
what has led us to undertake present studies [1-4]. They revealed that depending on
the degree of polyalcohol hydrolysis, the dressings made on the basis of PVA and
methylcellulose (MC) with the addition of hydrophilic substances were characterised
by distinct rheological properties and released the active substance in various
ways. The studies on the kinetics of the release of a locally applied antiseptic,
chlorhexidine digluconate, in biopharmaceutical model provided evidence of close to
rectilinear relationship between the amount of released substance and the time of
release for selected formulations.
AN - rayyan-563560895
AU - Pluta, J.
AU - Karolewicz, B.
IS - 3
KW - adhesive agent
chlorhexidine
drug carrier
drug derivative
article
bandage
bioremediation
chemistry
flow kinetics
human
hydrogel
materials testing
ointment
periodontitis
LA - ["English", "Polish"]
PY - 2002
SN - 0370-0747
SP - 20-29
ST - Physicochemical properties of stomatological dressings on the basis of
biodegradable nonionic polymers
T2 - Polim Med
TI - Physicochemical properties of stomatological dressings on the basis of
biodegradable nonionic polymers
VL - 32
ID - 14269
ER -
TY - JOUR
AN - rayyan-563561767
AU - Pogan, A. A.
AU - Buzatu, R.
AU - Onisei, D.
DO - 10.37358/rc.17.3.5513
IS - 3
PY - 2017
SP - 612-614
ST - Does adjunctive use of hyaluronic acid improve clinical outcome of mechanical
therapy for cases of mild aggressive periodontitis?
T2 - Revista de Chimie
TI - Does adjunctive use of hyaluronic acid improve clinical outcome of mechanical
therapy for cases of mild aggressive periodontitis?
85020749614&doi=10.37358%2frc.17.3.5513&partnerID=40&md5=b69a5270bf2b486bcda433b925
b08320
VL - 68
ID - 15141
ER -
TY - JOUR
AB - In the present prospective clinical trial, the effect of various regenerative
procedures performed at sites with angular bone defects were evaluated. The main
outcome variable was probing attachment alteration. MATERIAL AND METHODS: 40
subjects, aged 32-61 years participated. They met the following inclusion criteria:
(i) presence of generalized, advanced periodontal tissue destruction; (ii) presence
of 2 similar, contralateral, angular bone defects (experimental sites) located in
either the maxilla or the mandible; (iii) the defect site must exhibit a probing
pocket depth (PPD) of > or = 6 mm, a probing attachment level (PAL) of > or = 7 mm,
and a depth of the intrabony component of > or = 3 mm. All subjects had a good oral
hygiene standard, were in good general health and did not use any medication. Prior
to the start of the study, all subjects received non-surgical treatment for
periodontal disease. Baseline clinical measurements (plaque, gingivitis, PPD, PAL
and soft tissue recession) of the selected experimental sites were obtained 6
months after the completion of basic therapy. The 40 subjects were randomly divided
into 4 treatment groups including 10 subjects each: 3 membrane groups and one
Emdogain group. 1 h before surgery, the patients were given 3 g of Amoxicillin. No
other antibiotics were prescribed. The test and control sites were treated during
the same surgical session. Full thickness flaps were elevated and the exposed root
surfaces were planed. Membrane placement: The root surface was rinsed with saline.
A barrier membrane (Guidor or Resolut or Periodontal (e-PTFE) material) was
positioned to cover the defect and the adjacent 2-3 mm of bone tissue. The control
treatment was identical to the test treatment with the exception of barrier
placement. Emdogain placement: The exposed root surfaces at both the test and
control sites were, during a 2-min period, conditioned with a 24% EDTA gel.
Emdogain was applied to the exposed root surface of the test site. In the control
site, the vehicle, the PGA gel, was used as placebo control. The flaps were closed
and sutured to obtain a complete coverage of the intrabony defect. RESULTS: Re-
examinations, which were performed 12 months after surgery, disclosed that
regenerative therapy, including either the use of barrier membranes or application
of enamel matrix proteins to an instrumented root surface in an angular, intrabony
defect, enhanced outcome variables such as probing pocket depth and probing
attachment gain. It was furthermore demonstrated that clinical improvements were
better at sites with deep, than at sites with shallow, intrabony defects.
CONCLUSION: The 4 regenerative modalities tested appeared to be equally effective
in terms of PPD reduction and PAL gain, and superior to open flap curettage alone.
AN - rayyan-563561000
AU - Pontoriero, R.
AU - Wennström, J.
AU - Lindhe, J.
IS - 12
KW - chlorhexidine
drug derivative
enamel matrix proteins
enamel protein
adult
article
artificial membrane
clinical trial
comparative study
controlled study
female
human
male
methodology
middle aged
mouth hygiene
periodontal disease
periodontics
postoperative care
prospective study
statistics
time
LA - English
PY - 1999
SN - 0303-6979
SP - 833-840
ST - The use of barrier membranes and enamel matrix proteins in the treatment of
angular bone defects. A prospective controlled clinical study
TI - The use of barrier membranes and enamel matrix proteins in the treatment of
angular bone defects. A prospective controlled clinical study
VL - 26
ID - 14374
ER -
TY - JOUR
AB - This study proposed a drug delivery system based on a series of formulations
with chitosan gels, designed for local, intra-pocket treatment of periodontal
disease, containing two drugs (an antibiotic and a chimiotherapeutic-antimicrobian
agent: tetracycline hydrochloride (T) and metronidazole benzoate (M), respectively.
The formulations varied from the chitosan concentration (3-4%), and the drug
loading (1,2 and 3%) point of view. The objectives of the study were to outline the
rheological profiles of these formulations and also to evaluate the drug release.
All formulations exhibited pseudoplastic and thixotropic behaviour. The drug
kinetic profiles and the release mechanisms according to Peppas equation were set.
Based on the experimental data, an optimum concentration of chitosan in gel (3%)
for useful modulation of drug loading, as a success factor in local therapy of
periodontitis, was proposed.
AN - rayyan-563560486
AU - Popa, L.
AU - Ghica, M. V.
AU - Dinu-Pîrvu, C.
IS - 2
KW - chitosan gel
dental material
tetracycline
unclassified drug
article
drug design
drug formulation
drug release
flow kinetics
periodontitis
spectrophotometry
viscometry
LA - English
PY - 2013
SN - 0014-8237
SP - 240-250
ST - Periodontal Chitosan-gels designed for improved local intra-pocket drug
delivery
T2 - Farmacia
TI - Periodontal Chitosan-gels designed for improved local intra-pocket drug
delivery
VL - 61
ID - 13860
ER -
TY - JOUR
AB - This study proposed a drug delivery system based on a series of formulations
with chitosan gels, designed for local, intra-pocket treatment of periodontal
disease, containing two drugs (an antibiotic and a chimiotherapeutic-antimicrobian
agent: tetracycline hydrochloride (T) and metronidazole benzoate (M), respectively.
The formulations varied from the chitosan concentration (3-4%), and the drug
loading (1,2 and 3%) point of view. The objectives of the study were to outline the
rheological profiles of these formulations and also to evaluate the drug release.
All formulations exhibited pseudoplastic and thixotropic behaviour. The drug
kinetic profiles and the release mechanisms according to Peppas equation were set.
Based on the experimental data, an optimum concentration of chitosan in gel (3%)
for useful modulation of drug loading, as a success factor in local therapy of
periodontitis, was proposed.
AN - rayyan-563562164
AU - Popa, L.
AU - Ghica, M. V.
AU - Dinu-Pirvu, C. E.
IS - 2
PY - 2013
SN - ["0014-8237", "2065-0019"]
SP - 240-250
ST - PERIODONTAL CHITOSAN-GELS DESIGNED FOR IMPROVED LOCAL INTRA-POCKET DRUG
DELIVERY
T2 - FARMACIA
TI - PERIODONTAL CHITOSAN-GELS DESIGNED FOR IMPROVED LOCAL INTRA-POCKET DRUG
DELIVERY
VL - 61
Y2 - 3
ID - 15538
ER -
TY - JOUR
AB - Due to their antimicrobial, immunomodulatory, antioxidant, and regenerative
activities, culinary herbs have multiple medicinal uses, among which to prevent and
treat oral diseases. The whole essential oils (EOs) have multiple advantages over
purified components, such as a low probability to select for antimicrobial
resistance, synergic effects of different components, and multi-pharmacological
activities. In this study, we aimed to evaluate essential oils from Salvia
officinalis (sage), Satureja hortensis (summer savory), and Anethum graveolens
(dill) using an in vitro analysis of their antimicrobial activity against Gram-
positive and Gram-negative bacterial strains isolated from the oral cavity of
patients with periodontitis; the assays addressed both the planktonic and biofilm
growth states and used culture-based approaches. Some of the tested EOs exhibited
excellent bactericidal and antibiofilm activity, being active at concentrations as
low as 0.08–1.36 mg/mL. Flow cytometry was used to investigate the potential
mechanisms of their antibacterial activity and confirmed that the tested EOs act by
permeabilizing the bacterial membrane and by inhibiting the activity of the efflux
pumps. The immunomodulatory effect of the three EOs was determined by analyzing the
gene expression profiles for pro-and anti-inflammatory cytokines of the THP-1
cells. The summer savory EO induced a clear proinflammatory effect, while the
others did not significantly influence the cytokines profile of the tested cells.
Taken together, our results indicate that summer savory EO and, to a lesser extent,
sage and dill EOs could be used to inhibit bacteria involved in oral plaque
formation and to reduce the expression of genes known to contribute to the
inflammatory response using cell culture assessment.
AN - rayyan-563560113
AU - Popa, M.
AU - Măruțescu, L.
AU - Oprea, E.
AU - Bleotu, C.
AU - Kamerzan, C.
AU - Chifiriuc, M. C.
AU - Pircalabioru, G. G.
IS - 7
KW - 7300
flow cytometer
gas chromatograph
mass spectrometer
spectrophotometer
absinthol
anethum graveolens extract
antioxidant
camphor
carvacrol
chlorhexidine
essential oil
interleukin 10
interleukin 12
interleukin 1beta
interleukin 6
limonene
lipopolysaccharide
myristicin
perioceutic agent
pinene
plant extract
Salvia officinalis extract
satureja hortensis extract
terpene
terpenoid
thymol
unclassified drug
antigen presenting cell
article
bacterial growth
biofilm
cell permeabilization
controlled study
culinary herb
cytotoxicity
dill
flow cytometry
gel electrophoresis
gene expression
hydrodistillation
hydrophobicity
immunomodulation
Lactobacillus
mouth cavity
nonhuman
periodontal disease
priority journal
quorum sensing
spectrophotometry
tooth plaque
FACS Calibur
Nanodrop
LA - English
PY - 2020
SN - 2079-6382
SP - 1-14
ST - In vitro evaluation of the antimicrobial and immunomodulatory activity of
culinary herb essential oils as potential perioceutics
T2 - Antibiotics
TI - In vitro evaluation of the antimicrobial and immunomodulatory activity of
culinary herb essential oils as potential perioceutics
VL - 9
ID - 13487
ER -
TY - JOUR
AB - PVA/chitosan (PVA/CS) composite hydrogels incorporating silver nanoparticles
(AgNPs) were prepared by double-cross-linked procedures: freeze−thawing and
electrostatic interactions. Oxalic acid (OA) was used both for solubilization and
ionic cross-linking of CS. AgNPs covered by CS (CS-AgNPs) with an average diameter
of 9 nm and 18% silver were obtained in the presence of CS, acting as reducing
agent and particle stabilizer. The increase of the number of freeze−thaw cycles, as
well as of the PVA:CS and OA:CS ratios, resulted in an increase of the gel fraction
and elastic modulus. Practically, the elastic modulus of the hydrogels increased
from 3.5 kPa in the absence of OA to 11.6 kPa at a 1:1 OA:CS weight ratio, proving
that OA was involved in physical cross-linking. The physicochemical properties were
not altered by the addition of CS-AgNPs in low concentration; however,
concentrations higher than 3% resulted in low gel fraction and elastic modulus. The
amount of silver released from the composite hydrogels is very low (<0.4%), showing
that AgNPs were well trapped within the polymeric matrix. The composite hydrogels
displayed antimicrobial activity against S. aureus, K. pneumoniae or P. gingivalis.
The low cytotoxicity and the antibacterial efficacy of hydrogels recommend them for
wound and periodontitis treatment.
AN - rayyan-563561222
AU - Popescu, I.
AU - Constantin, M.
AU - Pelin, I. M.
AU - Suflet, D. M.
AU - Ichim, D. L.
AU - Daraba, O. M.
AU - Fundueanu, G.
DO - 10.3390/gels8050268
IS - 5
J2 - Gels
LA - eng
N1 - "Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley
41A, 700487 Iasi, Romania.; "Petru Poni" Institute of Macromolecular Chemistry,
Grigore Ghica Voda Alley 41A, 700487 Iasi, Romania.; "Petru Poni" Institute of
Macromolecular Chemistry, Grigore Ghica Voda Alley 41A, 700487 Iasi, Romania.;
"Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley 41A,
700487 Iasi, Romania.; Faculty of Medical Dentistry, Apollonia University of Iasi,
700511 Iasi, Romania.; Faculty of Medical Dentistry, Apollonia University of Iasi,
700511 Iasi, Romania.; "Petru Poni" Institute of Macromolecular Chemistry, Grigore
Ghica Voda Alley 41A, 700487 Iasi, Romania.
PY - 2022
ST - Eco-Friendly Synthesized PVA/Chitosan/Oxalic Acid Nanocomposite Hydrogels
Embedding Silver Nanoparticles as Antibacterial Materials
TI - Eco-Friendly Synthesized PVA/Chitosan/Oxalic Acid Nanocomposite Hydrogels
Embedding Silver Nanoparticles as Antibacterial Materials
VL - 8
Y2 - 4 y3 - 25
ID - 14596
ER -
TY - JOUR
AB - OBJECTIVES: The aim of this work was to review the current uses of
chlorhexidine (CHX) in dentistry based on its mechanism of action, whilst
highlighting the most effective protocols that render the highest clinical efficacy
whilst limiting adverse drug reactions. METHODS: A literature search was conducted
using the key words chlorhexidine, mechanism of action, adverse effects, and
dentistry using databases in the University of Toronto library system. The titles
and abstracts were read, and relevant articles were selected. RESULTS: A total of
1100 publications were identified, 100 were investigated, and 67 of them were used.
Out of the 67 selected articles, 12 were reviews on CHX; 5 articles focussed on CHX
gels; 13 focussed on CHX mouthwashes; 8 focussed on CHX products; 13 discussed
adverse effects associated with CHX; 13 focussed on periodontal pathology and
treatment; 6 focussed on implant periodontal and dental surgeries; 7 evaluated
effects on caries; 6 looked at the mechanisms of action; and 12 focussed on the
antibacterial and antimicrobial impact on the oral biome. There were multiple areas
of overlap amongst the articles, and results showed that CHX provides different
uses, but mainly as an adjunct to various treatments. Mouthwash was the most
superior medium when used in short time spans when mechanical prophylaxis was not
possible for the prevention of gingivitis and maintenance of oral hygiene. CHX
products are often used in periodontics, post-oral surgical procedures, and as a
prophylaxis for multiple invasive procedures with minimal adverse effects. Tooth
staining was the most negative adverse effect reported by patients. CONCLUSIONS:
CHX's antimicrobial properties make it an ideal prophylactic when mechanical
debridement is not possible. CHX mouthwash appears to be more effective compared to
gels. Concentrations of 0.12% to 0.2% are recommended; any mouthwash with
concentrations above 0.2% will unnecessarily increase the unwanted side effects.
CHX is useful amongst various areas of dentistry including oral surgery,
periodontics, and even general dentistry. For long-term treatments, especially in
periodontitis patients (stage I-III) undergoing nonsurgical treatments, CHX chips
are recommended. CHX chips are also recommended as an adjunct to implant
debridement in patients with peri-implant mucositis and peri-implantitis over CHX
mouthwash and gels.
AN - rayyan-563559834
AU - Poppolo Deus, F.
AU - Ouanounou, A.
DO - 10.1016/j.identj.2022.01.005
IS - 3
KW - chlorhexidine
mouth hygiene
gel
human
LA - English
PY - 2022
SN - 1875-595X
SP - 269-277
ST - Chlorhexidine in Dentistry: Pharmacology, Uses, and Adverse Effects
T2 - Int Dent J
TI - Chlorhexidine in Dentistry: Pharmacology, Uses, and Adverse Effects
VL - 72
ID - 13208
ER -
TY - JOUR
AB - Cofactor-independent glutamate racemases (GRs) that supply the d-glutamate
required for biosynthesis of the peptidoglycan that encapsulates bacterial cells
are attractive targets for the development of antibacterial drugs. Recombinant GR
from Fusobacterium nucleatum (FnGR), a Gram-negative anaerobe involved in
periodontal disease, was overproduced, purified, and characterized. Unlike most
other GRs, FnGR is a pseudosymmetric enzyme, catalyzing the racemization of
glutamate enantiomers with similar kinetic parameters (kcatl → d = 17.4 ± 0.8 s- 1,
Kml → d = 1.04 ± 0.07 mM, kcatd → l = 26 ± 1 s- 1, and Kmd → l = 17.0 ± 0.1 mM; pH
optimum ∼8.5). Mutational analysis of residue 151 (A151V) located at the entryway
to the active site revealed that FnGR is very sensitive to increased steric bulk at
this position. Blue native-polyacrylamide gel electrophoresis, Ferguson plot
analyses, and cross-linking studies, indicated that FnGR existed predominately as
dimers. Unlike Bacillus subtilis GR, the presence of glutamate did not
significantly alter the position of the monomer-dimer equilibrium of FnGR. © 2009
Elsevier Inc. All rights reserved.
AN - rayyan-563560688
AU - Potrykus, J.
AU - Flemming, J.
AU - Bearne, S. L.
DO - 10.1016/j.abb.2009.09.009
IS - 1
KW - alanine
dimer
glutamate racemase
racemase
unclassified drug
valine
amino acid sequence
article
Bacillus subtilis
catalysis
controlled study
enantiomer
enzyme active site
enzyme activity
enzyme localization
enzyme purification
enzyme specificity
enzyme structure
enzyme synthesis
mouth flora
mutational analysis
nonhuman
open reading frame
periodontal disease
pH
priority journal
protein quaternary structure
racemization
species comparison
LA - English
PY - 2009
SN - ["1096-0384", "0003-9861"]
SP - 16-24
ST - Kinetic characterization and quaternary structure of glutamate racemase from
the periodontal anaerobe Fusobacterium nucleatum
T2 - Arch. Biochem. Biophys.
TI - Kinetic characterization and quaternary structure of glutamate racemase from
the periodontal anaerobe Fusobacterium nucleatum
VL - 491
ID - 14062
ER -
TY - JOUR
AB - Mesoporous silica-based nanoparticles (MSNs) are considered promising drug
carriers because of their ordered pore structure, which permits high drug loading
and release capacity. The dissolution of Si and Ca from MSNs can trigger osteogenic
differentiation of stem cells towards extracellular matrix calcification, while Mg
and Sr constitute key elements of bone biology and metabolism. The aim of this
study was the synthesis and characterization of sol–gel-derived MSNs codoped with
Ca, Mg and Sr. Their physico-chemical properties were investigated by X-ray
diffraction (XRD), scanning electron microscopy with energy dispersive X-ray
analysis (SEM/EDX), transmission electron microscopy (TEM), Fourier transform
infrared spectroscopy (FTIR), X-ray fluorescence spectroscopy (XRF), Brunauer
Emmett Teller and Brunauer Joyner Halenda (BET/BJH), dynamic light scattering (DLS)
and ζ-potential measurements. Moxifloxacin loading and release profiles were
assessed with high performance liquid chromatography (HPLC) cell viability on human
periodontal ligament fibroblasts and their hemolytic activity in contact with human
red blood cells (RBCs) at various concentrations were also investigated. Doped MSNs
generally retained their textural characteristics, while different compositions
affected particle size, hemolytic activity and moxifloxacin loading/release
profiles. All co-doped MSNs revealed the formation of hydroxycarbonate apatite on
their surface after immersion in simulated body fluid (SBF) and promoted
mitochondrial activity and cell proliferation.
AN - rayyan-563560028
AU - Liverani, L.
AU - Tsamesidis, I.
AU - Lazaridou, M.
AU - Christodoulou, E.
AU - Beketova, A.
AU - Pappa, C.
AU - Triantafyllidis, K. S.
AU - Anastasiou, A. D.
AU - Papadopoulou, L.
AU - Bikiaris, D. N.
AU - Boccaccini, A. R.
DO - 10.3390/ijms22020577
IS - 2
KW - calcium
magnesium
moxifloxacin
strontium
article
biocompatibility
body fluid
cell proliferation
cell viability
controlled study
drug release
drug structure
erythrocyte
fibroblast
hemolysis
human
human cell
mitochondrion
particle size
sol-gel
synthesis
tissue engineering
X ray diffraction
X ray fluorescence spectrometry
zeta potential
LA - English
PY - 2021
SN - ["1422-0067", "1661-6596"]
SP - 1-25
ST - Article synthesis and characterization of mesoporous mg-and sr-doped
nanoparticles for moxifloxacin drug delivery in promising tissue engineering
applications
TI - Article synthesis and characterization of mesoporous mg-and sr-doped
nanoparticles for moxifloxacin drug delivery in promising tissue engineering
applications
VL - 22
ID - 13402
ER -
TY - JOUR
AB - Recent investigations imply that a key mechanism in the pathogenesis of
periodontal disease may be the ability of oral microorganisms to induce production
and/or activation of matrix metalloproteinases (MMPs) in the host tissues. It has
been suggested that the pharmacologic inhibition of MMP activity could play an
important role in achieving a desirable outcome in periodontal therapy. The
efficacy of locally delivered antibiotics on the level of gingival crevicular fluid
(GCF) stromelysin (SL) and tissue inhibitor of metalloproteinases (TIMP) on sites
with a history of a poor response to mechanical treatment was studied. Fifty-two
patients with 4 periodontal pockets ≤5 mm and bleeding on probing were randomized
into four groups of 13 patients. One group received scaling and root planing alone
and the other three groups received scaling and root planing plus a locally
delivered antimicrobial system. These included 25% tetracycline fiber, 2%
minocycline gel, and 25% metronidazole gel. The GCF samples taken at baseline and 6
weeks after treatments were analyzed using an enzyme linked immunosorbent assay
(ELISA). GCF SL levels significantly decreased after adjunctive tetracycline fiber
(paired t-test, P=0.020) and minocycline gel (paired t-test, P=0.023) treatments
whereas it remained almost unchanged in the other two groups. While the GCF TIMP
level did not change significantly in the scaling and root planing alone group, it
significantly increased for all three adjunctive antimicrobial treatments (for
tetracycline fiber P<0.001, minocycline gel P=0.005), metronidazole gel P<0.001).
The use of adjunctive locally delivered antimicrobial systems, particularly the
tetracycline family, may offer an advantage in changing the metalloproteinase
profile of the GCF to one more compatible with periodontal health.
AN - rayyan-563561059
AU - Pourtaghi, N.
AU - Radvar, M.
AU - Mooney, J.
AU - Kinane, D. F.
DO - 10.1902/jop.1996.67.9.866
IS - 9
metronidazole
minocycline
stromelysin
tetracycline
adult
aged
article
clinical trial
controlled study
female
gingivitis
human
male
periodontal disease
LA - English
PY - 1996
SN - 0022-3492
SP - 866-870
ST - The effect of subgingival antimicrobial therapy on the levels of stromelysin
and tissue inhibitor of metalloproteinases in gingival crevicular fluid
TI - The effect of subgingival antimicrobial therapy on the levels of stromelysin
and tissue inhibitor of metalloproteinases in gingival crevicular fluid
VL - 67
ID - 14433
ER -
TY - JOUR
AB - OBJECTIVES The aim of this report is to present the diagnostic path and
treatment of oral manifestations related to IgG4 disease. This disease has an
autoimmune nature and it has been identified as a diagnostic entity only recently.
IgG4 disease can affect different organs, mostly pancreas, biliary tree, salivary
glands, peri-orbital tissues, kidneys, lungs, lymph nodes, meninges, aorta,
breasts, prostate, thyroid, pericardium and skin. The oral manifestations are
heterogeneous and the disease can be difficult to diagnose, as they may overlap
with symptom-atological and clinical conditions of other oral conditions, such as
inflammation caused by bullous diseases (e.g. pemphigus and pem-phigoid),
autoimmune disease (e.g. oral lichen planus), related plaque gingivitis and oral
cancer. Currently in the literature only a few epidemiological data of diagnostic
procedure are reported. Biopsy represents the gold standard for diagnosis, as it
highlights the histopathological peculiarities that characterize this condition.
MATERIALS AND METHODS This case report describes a 73-years old female patient,
presenting to the Dental Emergency Department of the San Paolo hospital in Milan,
with pain to the right gum and to the right buccal mucosa for two weeks. The
patient felt no benefit following treatment with chlorhexidine digluconate-based
mouthwash. She had a diagnosis of IgG4 disease confirmed by the biopsy of lacrimal
glands. After intraoral physical examination the presence of slight plaque and
calcoulus accumulations was shown, as well as a picture of erosion of the gingival
epithelium at the level of all the quadrants, which was compatible with
desquamative gingivitis. It was also shown an ulcerated lesion at the level of the
right buccal mucosa. Actually, clinical data were not sufficient to make a
diagnosis. For this reason the patient underwent multiple incisional biopsy in
order to obtain a histopathological diagnosis. RESULTS The histological findings
showed a diffusely ulcerated oral mucosa and a dense lymphoplasmacytic inflammatory
cell infiltrate in the sample, obscuring its architecture. Lymphoid follicles with
germinal centres were present. All the plasmacells expressed IgG in their cytoplasm
and the IgG4 fraction was greater than 0.4 or anyway greater than 50 per high-power
field. The histological findings, supported by a remote pathological history
positive for IgG4 disease and physical examination, was compatible with salivary
changes related to IgG4 disease. CONCLUSIONS After obtaining histological diagnosis
the patient was treated with topical steroids, namely clo-betasol gel 0.05% for a
total of 10 weeks with decreasing applications. It was not necessary to send the
patient to other specialist because of the absence of systematic symptoms related
to IgG4 disease. After 3 months from the prescription of therapy with clo-betasol
gel, a control was per-formed and a complete resolu-tion of the signs and symptoms
of the disease at the level of oral cavity was observed. Subse-quently the patient
was scheduled for a six-months follow-up in order to monitor the progression of
oral manifestation of IgG4 disease. CLINICAL SIGNIFICANCE IgG4 disease is a rare
condition that in a few cases involves the cervical-facial district. It has only
recently been recognized as a well defined disease characterized by pathognomonic
histological and immunohistochemical findings that allow a correct diagnosis and an
adequate therapeutic treatment. In oral manifestation of IgG4 disease there are no
pathognomonic clinical signs and this can lead to a diagnostic delay causing an
accentuation of the symptoms and grater discomfort for the patient.
AN - rayyan-563560130
AU - Pradal, G.
AU - Sorrentino, D.
AU - Lombardi, N.
AU - Franchini, R.
AU - Moneghini, L.
AU - Varoni, E.
DO - 10.19256/d.cadmos.03.2020.06
IS - 3
clobetasol
immunoglobulin G4
aged
article
biopsy
buccal mucosa
case report
cell infiltration
clinical article
cytoplasm
female
follow up
gingiva
gingivitis
human
human tissue
immunoglobulin G4 related disease
inflammatory cell
lacrimal gland
mouth disease
physical examination
LA - Italian
PY - 2020
SN - 0011-8524
SP - 176-180
ST - Desquamative gingivitis in patient affected by IgG4 disease
T2 - Gengivite desquamativa in paziente con malattia da IgG4
TI - Desquamative gingivitis in patient affected by IgG4 disease
VL - 88
ID - 13504
ER -
TY - JOUR
AB - Background: There is a need for an anti-plaque agent that can be used on a
daily basis without the side effects of antibacterial chemicals such as
chlorhexidine. The present study was designed to evaluate the clinical and
microbiologic effects of commercially available gel and powder containing Acacia
arabica in subjects with gingivitis. Methods: One hundred and twenty subjects with
chronic generalized gingivitis were selected and randomly divided into four groups:
Group 1 - placebo group; Group 2 -Acacia arabica gel group; Group 3 -Acacia arabica
powder group; and Group 4 - 1% chlorhexidine gel group. Microbial counts of plaque
samples, the gingival index of Loe and Silness and the plaque index were evaluated
at baseline, 6 weeks, 12 weeks and 24 weeks. Microbial counts of plaque samples
were evaluated at all visits. Results: Acacia arabica gel and powder showed
significant clinical improvement in gingival and plaque index scores as compared to
a placebo. This improvement was comparable to 1% chlorhexidine gel. The difference
between gel and powder with regard to clinical and microbiological parameters was
not found to be significant at any time interval. Conclusions: Both Acacia arabica
gel and powder may be useful herbal formulations for chemical plaque control in
subjects with gingivitis. © 2012 Australian Dental Association.
AN - rayyan-563560528
AU - Pradeep, A. R.
AU - Agarwal, E.
AU - Bajaj, P.
AU - Naik, S. B.
AU - Shanbhag, N.
AU - Uma, S. R.
DO - 10.1111/j.1834-7819.2012.01714.x
IS - 3
KW - chlorhexidine
gum arabic
adult
article
bacterial count
comparative study
gingivitis
human
male
microbiology
periodontics
phytotherapy
tooth plaque
LA - English
PY - 2012
SN - ["0045-0421", "1834-7819"]
SP - 312-318
ST - Clinical and microbiologic effects of commercially available gel and powder
containing Acacia arabica on gingivitis
T2 - Aust. Dent. J.
TI - Clinical and microbiologic effects of commercially available gel and powder
VL - 57
ID - 13902
ER -
TY - COMP
AB - BACKGROUND: There is a need for an anti-plaque agent that can be used on a
daily basis without the side effects of antibacterial chemicals such as
chlorhexidine. The present study was designed to evaluate the clinical and
microbiologic effects of commercially available gel and powder containing Acacia
arabica in subjects with gingivitis. METHODS: One hundred and twenty subjects with
chronic generalized gingivitis were selected and randomly divided into four groups:
Group 1 - placebo group; Group 2 -Acacia arabica gel group; Group 3 -Acacia arabica
powder group; and Group 4 - 1% chlorhexidine gel group. Microbial counts of plaque
samples, the gingival index of Loe and Silness and the plaque index were evaluated
at baseline, 6 weeks, 12 weeks and 24 weeks. Microbial counts of plaque samples
were evaluated at all visits. RESULTS: Acacia arabica gel and powder showed
significant clinical improvement in gingival and plaque index scores as compared to
a placebo. This improvement was comparable to 1% chlorhexidine gel. The difference
between gel and powder with regard to clinical and microbiological parameters was
not found to be significant at any time interval. CONCLUSIONS: Both Acacia arabica
gel and powder may be useful herbal formulations for chemical plaque control in
subjects with gingivitis.
AN - rayyan-563560960
AU - Pradeep, A. R.
AU - Agarwal, E.
AU - Bajaj, P.
AU - Naik, S. B.
AU - Shanbhag, N.
AU - Uma, S. R.
CY - Australia
DO - 10.1111/j.1834-7819.2012.01714.x
ET - 3
J2 - Aust Dent J
KW - Adult
Chlorhexidine/therapeutic use
Dental Plaque/*drug therapy/microbiology
Dental Plaque Index
Gingivitis/*drug therapy/microbiology
Gum Arabic/*therapeutic use
Humans
Male
Periodontal Index
*Phytotherapy
Plant Preparations/therapeutic use
LA - eng
N1 - Department of Periodontics, Government Dental College and Research Institute,
Bangalore, Karnataka, India. periodontics_gdc@rediffmail.com
PY - 2012
SP - 312-8
ST - Clinical and microbiologic effects of commercially available gel and powder
T2 - Australian dental journal
TI - Clinical and microbiologic effects of commercially available gel and powder
VL - 57
Y2 - 9
ID - 14334
ER -
TY - JOUR
AB - Background: Certain plants used in folk medicine serve as a source of
therapeutic agents that have antimicrobial and other multipotential effects. This
prospective, randomized, placebo, and positively controlled clinical trial was
designed to evaluate the clinical and microbiologic effects of a commercially
available dentifrice containing aloe vera on the reduction of plaque and gingival
inflammation in patients with gingivitis. Methods: Ninety patients diagnosed with
chronic generalized gingivitis were selected and randomly divided into three
groups: group 1, placebo toothpaste; group 2, toothpaste containing aloe vera; and
group 3, toothpaste with polymer and fluoride containing triclosan. Clinical
evaluation was undertaken using a gingival index, plaque was assessed using a
modification of the Quigley-Hein index, and microbiologic counts were assessed at
baseline, 6 weeks, 12 weeks, and 24 weeks. A subjective evaluation was also
undertaken by questionnaire. Results: Toothpaste containing aloe vera showed
significant improvement in gingival and plaque index scores as well as
microbiologic counts compared with placebo dentifrice. These improvements were
comparable to those achieved with toothpaste containing triclosan. Conclusion:
Toothpaste containing aloe vera may be a useful herbal formulation for chemical
plaque control agents and improvement in plaque and gingival status. J Periodontol
2012;83:797-804.
AN - rayyan-563562628
AU - Pradeep, A. R.
AU - Agarwal, E.
AU - Naik, S. B.
DO - 10.1902/jop.2011.110371
IS - 6
PY - 2012
SN - 0022-3492
SP - 797-804
ST - Clinical and Microbiologic Effects of Commercially Available Dentifrice
Containing Aloe Vera: A Randomized Controlled Clinical Trial
TI - Clinical and Microbiologic Effects of Commercially Available Dentifrice
Containing Aloe Vera: A Randomized Controlled Clinical Trial
VL - 83
Y2 - 6
ID - 16002
ER -
TY - JOUR
AB - Background: Along with conventional periodontal surgical therapy, local
delivery of antibiotics may provide more effective treatment in smokers by
targeting tissue-invasive bacteria. The aim of this randomized, placebo-controlled,
doublemasked clinical trial was to evaluate the adjunctive effects of subgingivally
delivered 0.5% azithromycin (AZM) as an adjunct to scaling and root planing (SRP)
in the treatment of chronic periodontitis in smokers. Methods: Fifty-four patients
were randomized and categorized into two treatment groups: Group 1 - 26 subjects
who received (SRP) plus placebo gel and Group 2 - 28 subjects who received (SRP)
plus 0.5% azithromycin. Clinical parameters were recorded at baseline, 3, 6 and 9
months. They included Plaque Index (PI), modified Sulcus Bleeding Index (mSBI),
probing depth (PD) and clinical attachment level (CAL). Results: Azithromycin
resulted in significant improvements. A single application of AZM resulted in
attachment gain at 9 months of 2.44 ± 0.64 mm as compared to 0.18 ± 0.68 mm for the
placebo. Similarly, pocket depth and PI were significantly reduced but no change in
the mSBI was noted. Conclusions: When compared to the placebo, the adjunctive use
of 0.5% AZM resulted in significant improvement in clinical outcome in the
treatment of chronic periodontitis among smokers. © 2013 Australian Dental
Association.
AN - rayyan-563560492
AU - Pradeep, A. R.
AU - Bajaj, P.
AU - Agarwal, E.
AU - Rao, N. S.
AU - Naik, S. B.
AU - Kalra, N.
AU - Priyanaka, N.
DO - 10.1111/adj.12019
IS - 1
azithromycin
article
controlled study
female
follow up
gel
human
male
methodology
periodontics
smoking
treatment outcome
LA - English
PY - 2013
SN - ["0045-0421", "1834-7819"]
SP - 34-40
ST - Local drug delivery of 0.5% azithromycin in the treatment of chronic
periodontitis among smokers
T2 - Aust. Dent. J.
TI - Local drug delivery of 0.5% azithromycin in the treatment of chronic
periodontitis among smokers
VL - 58
ID - 13866
ER -
TY - JOUR
AB - BACKGROUND: Herbal agents such as Aloe vera (AV) have been used in medical
and dental therapy for thousands of years. AV has anti-inflammatory, antioxidant,
antimicrobial, hypoglycemic, healing-promoting, and immune-boosting properties.
This study aims to investigate the clinical effectiveness of locally delivered AV
gel used as an adjunct to scaling and root planing (SRP) in the treatment of
patients with type 2 diabetes mellitus (T2DM) and chronic periodontitis (CP).
METHODS: Sixty patients with probing depth (PD) ≥ 5 mm and clinical attachment
level (CAL) ≥ 3 mm were randomly divided into two groups. All patients underwent
SRP. Placebo gel was locally delivered to group 1 and AV gel to group 2. Full-mouth
plaque index (PI), modified sulcus bleeding index (mSBI), PD, and CAL were recorded
at baseline and 3 and 6 months. RESULTS: Patients in group 2 showed significantly
greater mean reductions in PI, mSBI, and PD and mean gain in CAL compared with
those in group 1 from baseline to 3 months. Gain in CAL was significantly greater
in group 2 at all time intervals versus group 1. CONCLUSION: Adjunctive use of
locally delivered AV gel, in comparison to locally delivered placebo gel, is
associated with greater reduction in PI, mSBI, and PD as well as more gain in CAL
in patients with T2DM and CP.
AN - rayyan-563560351
AU - Pradeep, A. R.
AU - Garg, V.
AU - Raju, A.
AU - Singh, P.
DO - 10.1902/jop.2015.150161
IS - 3
KW - chronic periodontitis
controlled study
dental scaling
follow up
human
periodontal disease
periodontal index
periodontitis
root planing
treatment outcome
LA - English
PY - 2016
SN - 1943-3670
SP - 268-274
ST - Adjunctive Local Delivery of Aloe Vera Gel in Patients With Type 2 Diabetes
and Chronic Periodontitis: A Randomized, Controlled Clinical Trial
TI - Adjunctive Local Delivery of Aloe Vera Gel in Patients With Type 2 Diabetes
and Chronic Periodontitis: A Randomized, Controlled Clinical Trial
VL - 87
ID - 13725
ER -
TY - JOUR
AB - Background: Certain plants used in folk medicine serve as a source of
therapeutic agent by having antimicrobial and other multi-potential effects. This
prospective, randomized, placebo and positively controlled clinical trial was
designed to evaluate the short-term clinical effects of a commercially available
gel containing Acacia arabica in the reduction of plaque and gingival inflammation
in subjects with gingivitis. Methods: Ninety subjects diagnosed with chronic
generalized gingivitis were selected and randomly divided into three groups: Group
I - placebo gel, Group II - gumtone gel and Group III - 1% chlorhexidine gel.
Clinical evaluation was undertaken using the gingival index of Loe and Silness and
the plaque index at baseline, 2 weeks, 4 weeks and 6 weeks. A subjective evaluation
was undertaken by questionnaire. Results: Gumtone gel showed significant clinical
improvement in gingival and plaque index scores as compared to a placebo gel. This
improvement was comparable to 1% chlorhexidine gel. Unlike chlorhexidine gel,
gumtone gel was not associated with any discolouration of teeth or unpleasant
taste. Conclusions: Gumtone gel may be a useful herbal formulation for chemical
plaque control agent and improvement in plaque and gingival status. © 2010
Australian Dental Association.
AN - rayyan-563560649
AU - Pradeep, A. R.
AU - Happy, D.
AU - Garg, G.
DO - 10.1111/j.1834-7819.2009.01180.x
IS - 1
KW - arabic acid
chlorhexidine
gum arabic
placebo
plant extract
Acacia
adult
article
chronic disease
clinical trial
comparative study
controlled study
female
follow up
gel
gingivitis
human
male
periodontics
prospective study
taste disorder
tooth discoloration
tooth plaque
treatment outcome
LA - English
PY - 2010
SN - ["0045-0421", "1834-7819"]
SP - 65-69
ST - Short-term clinical effects of commercially available gel containing Acacia
arabica: A randomized controlled clinical trial
T2 - Aust. Dent. J.
TI - Short-term clinical effects of commercially available gel containing Acacia
arabica: A randomized controlled clinical trial
VL - 55
ID - 14023
ER -
TY - COMP
AB - BACKGROUND: Certain plants used in folk medicine serve as a source of
therapeutic agent by having antimicrobial and other multi-potential effects. This
prospective, randomized, placebo and positively controlled clinical trial was
designed to evaluate the short-term clinical effects of a commercially available
gel containing Acacia arabica in the reduction of plaque and gingival inflammation
in subjects with gingivitis. METHODS: Ninety subjects diagnosed with chronic
generalized gingivitis were selected and randomly divided into three groups: Group
I - placebo gel, Group II - gumtone gel and Group III - 1% chlorhexidine gel.
Clinical evaluation was undertaken using the gingival index of Loe and Silness and
the plaque index at baseline, 2 weeks, 4 weeks and 6 weeks. A subjective evaluation
was undertaken by questionnaire. RESULTS: Gumtone gel showed significant clinical
improvement in gingival and plaque index scores as compared to a placebo gel. This
improvement was comparable to 1% chlorhexidine gel. Unlike chlorhexidine gel,
gumtone gel was not associated with any discolouration of teeth or unpleasant
taste. CONCLUSIONS: Gumtone gel may be a useful herbal formulation for chemical
plaque control agent and improvement in plaque and gingival status.
AN - rayyan-563561293
AU - Pradeep, A. R.
AU - Happy, D.
AU - Garg, G.
CY - Australia
DO - 10.1111/j.1834-7819.2009.01180.x
ET - 1
J2 - Aust Dent J
KW - *Acacia
Adult
Anti-Infective Agents, Local/adverse effects/*therapeutic use
Chlorhexidine/adverse effects/therapeutic use
Chronic Disease
Dental Plaque/*prevention & control
Dental Plaque Index
Female
Follow-Up Studies
Gels
Gingival Pocket/prevention & control
Gum Arabic/therapeutic use
Humans
Male
Periodontal Index
Placebos
Plant Extracts/*therapeutic use
Prospective Studies
Single-Blind Method
Taste Disorders/chemically induced
Tooth Discoloration/chemically induced
Treatment Outcome
LA - eng
N1 - Department of Periodontics, Government Dental College and Research Institute,
Fort, Bangalore, Karnataka, India.
PY - 2010
SP - 65-9
ST - Short-term clinical effects of commercially available gel containing Acacia
arabica: a randomized controlled clinical trial
T2 - Australian dental journal
TI - Short-term clinical effects of commercially available gel containing Acacia
arabica: a randomized controlled clinical trial
VL - 55
Y2 - 3
ID - 14667
ER -
TY - JOUR
AB - Effective plaque control is essential for prevention of gingivitis and
periodontitis. The aim of this 24-week follow-up parallel study was to evaluate the
efficacy of three topical gels in the treatment of gingivitis as compared to
placebo gel. One hundred twenty subjects diagnosed with chronic generalized
gingivitis were selected and randomly divided into four groups: Group 1--placebo
gel, Group 2--chlorhexidine (CHX) gel, Group 3--metronidazole (MTZ) gel and Group
4--chlorhexidine-metronidazole (CHX-MTZ) gel. Clinical evaluation was undertaken
using the gingival index (GI) of Löe and Silness and the plaque index (PI) at
baseline, 6 weeks, 12 weeks and 24 weeks. Microbiological analysis was also done at
the same time intervals. A subjective evaluation was also undertaken by
questionnaire. Groups treated with all three gels (CHX, MTZ and CHX-MTZ) showed
significant clinical and microbiological improvement as compared to the group
treated with a placebo gel. The reduction in PI, GI and microbiological count in
the group treated with the CHX-MTZ combination gel was significant when compared to
those treated with CHX and MTZ gels. Topical application of CHX or MTZ alone or in
combination may have a role in the management of gingivitis.
AN - rayyan-563560524
AU - Pradeep, A. R.
AU - Kumari, M.
AU - Priyanka, N.
AU - Naik, S. B.
IS - 4
KW - chlorhexidine
metronidazole
Actinomyces
adult
article
bacterial count
chronic disease
clinical trial
comparative study
controlled study
drug combination
drug effect
female
follow up
gel
gingivitis
human
male
microbiology
periodontics
questionnaire
Streptococcus
tooth plaque
LA - English
PY - 2012
SN - 1466-2094
SP - 91-96
ST - Efficacy of chlorhexidine, metronidazole and combination gel in the treatment
of gingivitis--a randomized clinical trial
TI - Efficacy of chlorhexidine, metronidazole and combination gel in the treatment
of gingivitis--a randomized clinical trial
VL - 14
ID - 13898
ER -
TY - JOUR
AB - Background: Recent developments suggest that the local delivery of
antimicrobials into periodontal pockets can improve periodontal health. The present
study was undertaken to investigate the clinical and microbiologic effectiveness of
azithromycin (AZM) at 0.5% concentration in an indigenously prepared bioabsorbable
controlledrelease gel as an adjunct to non-surgical mechanical therapy in the
treatment of chronic periodontitis. Methods: Eighty patients were categorized into
two treatment groups: scaling and root planing (SRP) only (group 1) and SRP plus
0.5% AZM (group 2). Clinical parameters were recorded at baseline and 1, 2, and 3
months; they included modified gingival index, modified sulcus bleeding index,
probing depth (PD), and clinical attachment level (CAL). At baseline and 6 and 12
weeks, microbiologic assessment was done of the percentage of morphologically
different microorganisms (coccoid cells, others [straight rods, filaments, and
fusiforms], motile rods, and spirochetes) using darkfield microscopy. The mean
concentration of 0.5% AZM in gingival crevicular fluid was estimated by reverse
phase high performance liquid chromatography. Results: Both therapies resulted in
significant improvements. Mean PD reduction from baseline to 3 months was 2.13 ±
0.35 mm and 2.53 ± 0.52 in groups 1 and 2, respectively. Mean CAL gain from
baseline to 3 months was 0.60 ± 0.63 mm and 1.07 ± 0.70 mm in groups 1 and 2,
respectively. All microbiologic categories showed significant improvement in both
groups, with greater improvement in the test group. The mean concentration of AZM
at all observed periods (baseline to 28 days) provided sufficient antimicrobial
activity (>2 μg/ml) and fulfilled the conditions for a controlled-release device.
Conclusion: Although both treatment strategies seemed to benefit the patients, the
adjunctive use of 0.5% AZM as a controlled drug-delivery system enhanced the
clinical and microbiologic results as shown by the intergroup comparison.
AN - rayyan-563560694
AU - Pradeep, A. R.
AU - Sagar, S. V.
AU - Daisy, H.
DO - 10.1902/jop.2008.070589
IS - 11
azithromycin
adult
article
bacterial count
clinical trial
controlled study
drug effect
follow up
gel
gingivitis
human
methodology
microbiology
middle aged
periodontics
periodontitis
treatment outcome
LA - English
PY - 2008
SN - 0022-3492
SP - 2125-2135
ST - Clinical and microbiologic effects of subgingivally delivered 0.5%
azithromycin in the treatment of chronic periodontitis
TI - Clinical and microbiologic effects of subgingivally delivered 0.5%
azithromycin in the treatment of chronic periodontitis
VL - 79
ID - 14068
ER -
TY - JOUR
AB - The bacterial colonization of absorbable membranes used for guided tissue
regeneration (GTR), as well as their rapid degradation that can cause their
rupture, are considered the major reasons for clinical failure. To address this,
composite membranes of polycaprolactone (PCL) and gelatin (Gel) loaded with zinc
oxide nanoparticles (ZnO-NPs; 1, 3 and 6 wt% relative to PCL content) were
fabricated by electrospinning. To fabricate homogeneous fibrillar membranes, acetic
acid was used as a sole common solvent to enhance the miscibility of PCL and Gel in
the electrospinning solutions. The effects of ZnO-NPs in the physico-chemical,
mechanical and in vitro biological properties of composite membranes were studied.
The composite membranes showed adequate mechanical properties to offer a
satisfactory clinical manipulation and an excellent conformability to the defect
site while their degradation rate seemed to be appropriate to allow successful
regeneration of periodontal defects. The presence of ZnO-NPs in the composite
membranes significantly decreased the planktonic and the biofilm growth of the
Staphylococcus aureus over time. Finally, the viability of human osteoblasts and
human gingival fibroblasts exposed to the composite membranes with 1 and 3 wt% of
ZnO-NPs indicated that those membranes are not expected to negatively influence the
ability of periodontal cells to repopulate the defect site during GTR treatments.
The results here obtained suggest that composite membranes of PCL and Gel loaded
with ZnO-NPs have the potential to be used as structurally stable GTR membranes
with local antibacterial properties intended for enhancing clinical treatments.
AN - rayyan-563560151
AU - Prado-Prone, G.
AU - Silva-Bermudez, P.
AU - Bazzar, M.
AU - Focarete, M. L.
AU - Rodil, S. E.
AU - Vidal-Gutiérrez, X.
AU - García-Macedo, J. A.
AU - García-Pérez, V. I.
AU - Velasquillo, C.
AU - Almaguer-Flores, A.
DO - 10.1088/1748-605X/ab70ef
IS - 3
KW - acetic acid
gelatin
polycaprolactone
article
bacterial growth
biocompatibility
biofilm
cell viability
comparative study
controlled study
electrospinning
fibroblast
gingiva
human
in vitro study
melting temperature
miscibility
nanofabrication
osteoblast
plankton
tensile strength
thermogravimetry
tissue regeneration
Young modulus
LA - English
PY - 2020
SN - ["1748-605X", "1748-6041"]
ST - Antibacterial composite membranes of polycaprolactone/gelatin loaded with
zinc oxide nanoparticles for guided tissue regeneration
T2 - Biomed. Mater.
TI - Antibacterial composite membranes of polycaprolactone/gelatin loaded with
VL - 15
ID - 13525
ER -
TY - JOUR
AB - The bacterial colonization of absorbable membranes used for guided tissue
regeneration (GTR), as well as their rapid degradation that can cause their
rupture, are considered the major reasons for clinical failure. To address this,
composite membranes of polycaprolactone (PCL) and gelatin (Gel) loaded with zinc
oxide nanoparticles (ZnO-NPs; 1, 3 and 6 wt% relative to PCL content) were
fabricated by electrospinning. To fabricate homogeneous fibrillar membranes, acetic
acid was used as a sole common solvent to enhance the miscibility of PCL and Gel in
the electrospinning solutions. The effects of ZnO-NPs in the physico-chemical,
mechanical and in vitro biological properties of composite membranes were studied.
The composite membranes showed adequate mechanical properties to offer a
satisfactory clinical manipulation and an excellent conformability to the defect
site while their degradation rate seemed to be appropriate to allow successful
regeneration of periodontal defects. The presence of ZnO-NPs in the composite
membranes significantly decreased the planktonic and the biofilm growth of the
Staphylococcus aureus over time. Finally, the viability of human osteoblasts and
human gingival fibroblasts exposed to the composite membranes with 1 and 3 wt% of
ZnO-NPs indicated that those membranes are not expected to negatively influence the
ability of periodontal cells to repopulate the defect site during GTR treatments.
The results here obtained suggest that composite membranes of PCL and Gel loaded
with ZnO-NPs have the potential to be used as structurally stable GTR membranes
with local antibacterial properties intended for enhancing clinical treatments.
AN - rayyan-563562345
AU - Bazzar, M.
AU - Focarete, M. L.
AU - Rodil, S. E.
AU - Vidal-Gutierrez, X.
AU - Garcia-Macedo, J. A.
AU - Garcia-Perez, V. I.
DO - 10.1088/1748-605X/ab70ef
IS - 3
PY - 2020
SN - ["1748-6041", "1748-605X"]
ST - Antibacterial composite membranes of polycaprolactone/gelatin loaded with
TI - Antibacterial composite membranes of polycaprolactone/gelatin loaded with
VL - 15
Y2 - 2
ID - 15719
ER -
TY - JOUR
AB - Periodontitis, a disease involving supportive structures of the teeth
prevails in all groups, ethnicities, races and both genders. The relationship
between bacterial plaque and the development of periodontal disease and caries is
well established. Antibacterial agents have been used effectively in the management
of periodontal infection. The effectiveness of mechanical debridement of plaque and
repeated topical and systemic administration of antibacterial agents are limited
due to the lack of accessibility to periodontopathic organisms in the periodontal
pocket. Systemic administration of drugs leads to therapeutic concentrations at the
site of infection, but for short periods of time, forcing repeated dosing for
longer periods. Local delivery of antimicrobials has been investigated for the
possibility of overcoming the limitations of conventional therapy. The use of
sustained release formulations to deliver antibacterials to the site of infection
(periodontal pocket) has recently gained interest. These products provide a long-
term,effective treatment at the site of infection at much smaller doses.
Biodegradable polymers are extensively employed in periodontal drug delivery
devices because of their abundant source, lack of toxicity, and high tissue
compatibility. A major advantage of natural polymers is that they do not affect
periodontal tissue regeneration. Amongst various natural polymers, chitosan, a
deacetylated product of chitin is widelyused in drug delivery devices. Since it
exhibits favourable biological properties such as non-toxicity, bioco patibility,
biodegradability and wound healing traits, it has attracted great attention in the
pharmaceutical and biomedical fields. The conventional treatment consists of tooth
surface mechanical cleaning and root planning, associated or not to the systemic
use of high concentrations of antibiotics, but with reduced effectiveness, and
adverse effects. The patient compliance to the therapeutic is committed too. In the
last decades, the treatment has been optimized for the use of drug delivery systems
to the periodontal pocket, with the advantage of delivering the drug in the
specific site, sustaining and/or controlling the drug concentration. Recently, the
use of new drug delivery systems has been receiving great interest. This review
approaches the main delivery systems for the administration of drugs to the
periodontal pocket, their usefulness, as well as the advancement of these systems
effectiveness in the periodontal therapy. © arjournals.org.
AN - rayyan-563560607
AU - Pragati, S.
AU - Ashok, S.
AU - Kuldeep, S.
DO - 10.5138/ijdd.2009.0975.0215.01001
IS - 1
KW - actinide
amoxicillin
antibiotic agent
antisense oligonucleotide
atrigel
chitosan
chlorhexidine
ciprofloxacin
dentamycin e
doxycycline
doxycycline hyclate
drug carrier
gluconic acid
harungana madagascariensis extract
immunoliposome
ipriflavone
lidocaine
macrogol
metronidazole
microparticle
minocycline
nanoparticle
ornidazole
penicillin G
plant extract
polyvinyl alcohol
propolis
tetracycline
triclosan
unclassified drug
unindexed drug
acrylic strip
antibiotic therapy
biocompatibility
biodegradability
dental procedure
dental surgery
drug approval
drug choice
drug dosage form
drug efficacy
drug formulation
drug implant
drug safety
drug saliva level
drug solubility
film
Food and Drug Administration
gel
gingiva bleeding
gingivitis
hollow fiber
human
injectable gel
injection
lavage
liposomal delivery
low drug dose
mouth hygiene
mucoadhesion
periodontal disease
periodontal pocket
periodontics
periodontitis
review
surgical approach
tissue graft
tooth infection
tooth plaque
treatment planning
arestin
atridox
elyzol
gluconate
periochip
periostat
LA - English
PY - 2011
SN - 0975-0215
SP - 1-14
ST - Recent advances in periodontal drug delivery systems
T2 - Intl. J. Drug Deliv.
TI - Recent advances in periodontal drug delivery systems
VL - 1
ID - 13981
ER -
TY - JOUR
AB - Objective: The present study describes the use of in situ gel in periodontal
drug delivery systems which contain gellan gum (0.4-0.6% w/v), pluronic F127 (14,
15, and 16% w/v), and drug ciprofloxacin HCl (0.1% w/v). Number of peoples around
the world suffered from dental problem and ultimate fear is tooth loss hence in
situ gelling system was designed for the treatment of periodontal diseases. The
therapeutic efficacy of drug can be greatly improved by prolonging its contact
time. Methods: Formulations were developed by simple solution method. Each
formulation was characterized in terms of in gelling strength, viscosity, rheology,
content uniformity, in vitro drug release, and syringeability. Results: In vitro
gelation time and the nature of the gel formed in simulated saliva for prepared
formulations showed polymeric concentration dependency. Drug release data from all
formulations were fitted to different kinetic models, and the Korsmeyer-Peppas
model was the best fit model. Drug release was significantly decreased as the
concentration of each polymer component was increased. Increasing the concentration
of each polymeric component significantly increased viscosity, syringeability, and
time for 50%, 70%, and 90% drug release. In conclusion, the formulations described
offer a wide range of physical and drug release characteristics. The formulation
containing 0.6% w/v of gellan gum and 14% w/v of pluronic F127 exhibited superior
physical characteristics. The formulation stored at 4°C before application, which
is syringeable through 21 gauge needle. Conclusion: This formulation was made to
inject directly into periodontal pocket where it immediately converts into gel form
at body temperature.
AN - rayyan-563560319
AU - Prakash Ashish, G.
AU - Rahul, Y.
AU - Mukesh, R.
AU - Prakash, M.
DO - 10.22159/ajpcr.2017.v10i6.17558
IS - 6
KW - ciprofloxacin
gellan
poloxamer
article
drug efficacy
drug formulation
drug release
flow kinetics
gel
periodontitis
saliva
simulation
viscosity
LA - English
PY - 2017
SN - ["2455-3891", "0974-2441"]
SP - 154-159
ST - Formulation and evaluation of in situ gel containing ciprofloxacin
hydrochloride in the treatment of periodontitis
TI - Formulation and evaluation of in situ gel containing ciprofloxacin
hydrochloride in the treatment of periodontitis
VL - 10
ID - 13693
ER -
TY - JOUR
AB - Introduction: Pomegranate (Punica granatum) fruit extract has anti-
inflammatory, anti-bacterial, anti-oxidant and immune-modulatory features. Due to
increased bacterial resistance to synthetic agents Pomegranate Extract Gel (PEG)
could become a natural remedy for the treatment of periodontal disease. Aim: To
compare topically applied PEG, chlorhexidine (CHX) gel, ornidazole-chlorhexidine
(ORN-CHX) gel and Placebo Gel (PG) on clinical parameters and on gingival
crevicular fluid (GCF) levels of interleukin-1β (IL-1β) and IL-8 and chemokine (C-C
motif) ligand 28 (CCL28) levels in a two week human experimental gingivitis model.
Materials and Methods: Eighty systemically healthy subjects were randomly assigned
to one of the four groups; Group I: PEG, Group II: CHX gel, Group III: ORN-CHX gel,
and Group IV: PG. On the selected quadrant the subjects refrained from routine
hygiene procedure and solely used the topical gel. The primary outcome measured
were IL-1β, IL-8 and CCL28 levels from GCF at baseline and 14 days. Gingival Index
(GI), Plaque Index (PI), Bleeding On Probing (BOP) and Probing Depth (PD) were
secondarily assessed at baseline, 14 and 60 days. Paired t-test and one-way ANOVA
followed by post-hoc Tukey’s test was used for intra and intergroup comparisons
with p-value of 0.05 as significant. Results: The PEG had an inhibitory effect on
pro-inflammatory cytokines and chemokine. PEG showed significantly less increase in
IL-1β, IL-8 (p=0.003, 0.002) while CCL28 levels showed no difference from baseline
(p=0.15) when compared to other three groups (p<0.001). The BOP and GI among
subjects using PEG showed less increase (p=0.01, 0.05) compared to other three gels
(p<0.001) after 14 days. PEG and CHX-ORD gel were similar (p=0.96) in exhibiting
lowered PI. Conclusion: Pomegranate extract gel was effective in reducing the
inflammatory markers and can be used as an adjunct to mechanical therapy for the
treatment of gingivitis.
AN - rayyan-563560284
AU - Prakash, J.
AU - Bhatnagar, V.
AU - Nath, S.
AU - Pulikkotil, S.
AU - Prajapati, V. K.
DO - 10.7860/JCDR/2017/31035.10845
IS - 11
KW - CTRI/2017/08/009559
Raybio
antiinfective agent
biological marker
chemokine
Chemokine ligand 28
chlorhexidine
cytokine
interleukin 1beta
interleukin 8
ornidazole
Ornigreat gel
pomegranate extract
unclassified drug
adult
article
controlled study
female
gingivitis
human
hypersensitivity
male
nonhuman
young adult
LA - English
PY - 2017
SN - ["0973-709X", "2249-782X"]
SP - ZC12-ZC17
ST - Effect of punica granatum extract gel on gingival crevicular fluid levels of
interleukin-1β, interleukin-8 and CCL28 levels: Randomised controlled clinical
trial
TI - Effect of punica granatum extract gel on gingival crevicular fluid levels of
interleukin-1β, interleukin-8 and CCL28 levels: Randomised controlled clinical
trial
VL - 11
ID - 13658
ER -
TY - JOUR
AB - The biosynthesis of silver nanoparticles using plant extracts is a safe and
efficient method. Human periodontal stem cells (hPDLSCs) can promote periodontal
tissue formation for regenerative therapy. The current study aimed to biosynthesize
silver nanoparticles (AgNPs) using stem bark extracts from Oroxylum indicum (L)
Kurz (OI) as a reducing agent (OI/AgNPs) and investigate the biological properties
of OI/AgNPs on human periodontal ligament stem cells (hPDLSCs). The OI/AgNPs were
biosynthesized and characterized using UV–vis spectrophotometry (UV‒vis), Fourier
transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission
electron microscopy (TEM) and zeta potential analyses. The hPDLSCs were stimulated
with hydrogen peroxide (H2O2, H2O2-hPDLSCs) and bacterial lipopolysaccharide (LPS,
LPS-hPDLSCs) and encapsulated in the hydrogel. After that, the levels of cell
viability, interleukin-1beta (IL-1b), alkaline phosphatase (ALP) activity, and
calcium content were measured and compared with quercetin (QT) as a reference
flavonoid. The OI/AgNPs were stable spherical nanoparticles with a size range of
21.49 ± 0.32 nm, and biosynthesis enhanced the antioxidant and biological effects
of the OI/AgNPs. The accumulation of OI/AgNPs in the cytoplasm of hPDLSCs with high
levels of cell viability was demonstrated. OI/AgNPs increased the cell growth of
H2O2-hPDLSCs and decreased the levels of IL-1b secretion from LPS-hPDLSCs. The
OI/AgNPs increased the ALP activity and calcium content of the hPDLSCs. In
conclusion, the biosynthesized OI/AgNPs were noncytotoxic and could protect hPDLSCs
against oxidative stress and inflammatory stimuli and promote osteoblastic
differentiation; thus, they are applicable for the regenerative treatment of
peri-implantitis.
AN - rayyan-563559764
AU - Prapaipittayakhun, J.
AU - Boonyuen, S.
AU - Zheng, A. L. T.
AU - Apinyauppatham, K.
AU - Arpornmaeklong, P.
DO - 10.1016/j.onano.2022.100117
biological product
calcium
flavonoid
hydrogen peroxide
interleukin 1beta
Oroxylum indicum extract
plant extract
quercetin
silver nanoparticle
unclassified drug
article
bioassay
biological activity
bone characteristics and functions
cell encapsulation
cell growth
cell isolation
cell viability
controlled study
cytotoxicity
DPPH radical scavenging assay
encapsulation
flow cytometry
human
human cell
IC50
Oroxylum
osteogenic differentiation
oxidative stress
particle size
physical chemistry
protein expression
stem cell expansion
total flavonoid content assay
ultraviolet visible spectrophotometry
X ray diffraction
zeta potential
LA - English
PY - 2023
SN - 2352-9520
ST - Biologic effects of biosynthesized Oroxylum indicum/silver nanoparticles on
human periodontal ligament stem cells
T2 - OpenNano
TI - Biologic effects of biosynthesized Oroxylum indicum/silver nanoparticles on
human periodontal ligament stem cells
VL - 9
ID - 13138
ER -
TY - JOUR
AB - AIMS: Investigate the effect of toothbrushing with 0.2% chlorhexidine gel on
oral health and pneumonia amongst patients with a neurodisability who are fed via
percutaneous endoscopic gastrostomy. METHOD: Forty-nine patients at the Royal
Hospital for Neuro-disability were recruited to an observational study. Daily
toothbrushing with 0.2% chlorhexidine gel was undertaken for 12 months by trained
nursing staff. Plaque and gingival health were assessed every six weeks using the
Simplified Debris Index and the Basic Periodontal Examination. The annual incidence
and prevalence of episodes of pneumonia experienced by patients whilst using the
chlorhexidine gel were compared to rates from the previous year. RESULTS: Plaque
levels and the proportion of patients with periodontal pocketing > 3.5 mm
significantly reduced, P < .001, with chlorhexidine toothbrushing. Total number of
pneumonia episodes (75-67), antibiotics administered (73-64), and radiographs taken
(19 to 16) were lower in the year wherein chlorhexidine was employed, and
hospitalisations dropped by 31% (16-11), but these reductions were not
statistically significant. No adverse events were reported. CONCLUSION: Daily
toothbrushing with 0.2% chlorhexidine undertaken by a trained and supported nursing
staff was effective in improving oral health but did not significantly affect
annual rates of pneumonia amongst patients.
AN - rayyan-563560178
AU - Prasad, R.
AU - Daly, B.
AU - Manley, G.
DO - 10.1111/scd.12414
IS - 5
KW - chlorhexidine
adult
health
human
incidence
pneumonia
tooth brushing
LA - English
PY - 2019
SN - 1754-4505
SP - 524-532
ST - The impact of 0.2% chlorhexidine gel on oral health and the incidence of
pneumonia amongst adults with profound complex neurodisability
T2 - Spec Care Dentist
TI - The impact of 0.2% chlorhexidine gel on oral health and the incidence of
pneumonia amongst adults with profound complex neurodisability
VL - 39
ID - 13552
ER -
TY - CPAPER
AB - The applications of lasers in medicine, both in the field of diagnosis and
treatment are gaining momentum. In dentistry in particular, numerous types of
lasers with a wide range of characteristics are being utilized in all fields. In
consequence, a lot of experience and knowledge has been gained in the last two
decades in this domain; this resulted in the development of novel technologies and
devices. A brief overview is made in the first part of this article on these
topics. The treatment of periodontal disease with laser therapy is pointed out, as
well as the photodynamic therapy which is using LLLT for the activation of the
sensitizing gel that is introduced in the periodontal pockets. This paper reviews
also the application of photodynamic therapy in clinical trials which have
different results; a standardization of the protocol utilized for this procedure is
concluded to be necessary.
AN - rayyan-563562416
AU - Pribac, V.
AU - Todea, C.
AU - Duma, V. F.
DO - 10.1117/12.2192010
PY - 2016
T2 - HIGH-END MEDICINE BASED ON LASER AND BIOTECHNOLOGIES
TI - Low-Level Laser Therapy (LLLT) for periodontal pockets. A review
VL - 9670
ID - 15790
ER -
TY - JOUR
AN - rayyan-563560696
AU - Prikuls, V. F.
AU - Gerasimenko, M. I.
IS - 6
KW - actihaemyl
actovegin
antioxidant
drug derivative
heme
adult
article
chronic disease
gel
human
middle aged
periodontitis
phototherapy
LA - Russian
PY - 2008
SN - 0042-8787
SP - 42-43
ST - Effectiveness of photo- and mesophotophoresis in the combined treatment of
patients with chronic generalized parodontitis
T2 - Vopr Kurortol Fizioter Lech Fiz Kult
TI - Effectiveness of photo- and mesophotophoresis in the combined treatment of
patients with chronic generalized parodontitis
ID - 14070
ER -
TY - JOUR
AB - 115 patients with chronic generalized parodontitis of middle or severe degree
were examined and for them special treatment was developed with laser therapy and
photophoresis use. The application of mentioned above physical and pharmacological
methods in comprehensive treatment let to shorten the course of treatment and
prolong the remission time.
AN - rayyan-563560692
AU - Prikuls, V. F.
AU - Gerasimenko, M. I.
AU - Moskovets, O. N.
AU - Skovorod'ko, S. N.
IS - 4
KW - chlorhexidine
metrogil denta
metronidazole
unclassified drug
adult
article
chronic disease
dental procedure
drug combination
gel
human
infection control
methodology
middle aged
pathology
periodontal disease
PUVA
LA - Russian
PY - 2008
SN - 0039-1735
SP - 18-23
ST - Gel Metrogil Denta photopheresis use in comprehensive treatment of patients
with chronic generalized parodontitis
TI - Gel Metrogil Denta photopheresis use in comprehensive treatment of patients
with chronic generalized parodontitis
VL - 87
ID - 14066
ER -
TY - JOUR
AB - Background: Acinetobacter baumannii, a potential nosocomial pathogen has
stealthily gained entry into the oral cavity. Their association with other
pathogens like Pseudomonas aeruginosa in chronic and aggressive periodontitis cases
is well documented. The magnitude of problem caused by A. baumannii could be
attributed to resistance genes acquired by the organism. Since the microbiome of
oral cavity is heterogeneous and complex, the transfer of genes from multidrug
resistant A. baumannii may be a serious threat in infection control and management.
In view of this fact, the present study aims to categorize and characterize drug
resistant genes present in each of the 19 genomes of Acinetobacter Sp. selected for
the study. Methods: About 19 genome sequences of Acinetobacter spp. with the
predominance of different strains of A. baumannii was genotyped using in silico
restriction digestion and pulse field gel electrophoresis (PFGE). Further, the
prevalence of common drug resistant genes in the genome of various Acinetobacter
spp. was recorded using in silico PCR analysis. Results: Based on the PFGE pattern,
phylogenetic tree was constructed and the genomes were clustered into 6 genotypes.
Genotype 4 (n = 8; 42.10%) and 5 (n = 6; 31.57%) were predominant, followed by
genotypes 2 (n = 2; 10.52%), 1, 3 and 6 (n = 1; 5.26%). Three species were excluded
from the list since they were negative for most of the drug resistant genes tested.
Prevalence of drug resistant genes in each of the 16 genomes analysed found oxa-51,
ISAba 1 and ADC 1 to be the major genes found in A. baumannii. Acinetobacter spp.
belonging to genotypes 4 and 5 were found to harbour 6-10 and 2-8 potential drug
resistant genes respectively. Conclusion: The present study showed cluster of
multi-drug resistant genes in genomes analysed, thus, warranting the need for
antibiotic surveillance, alternate therapeutic measures and development of novel
antimicrobials. An extensive study on the genes conferring drug resistance in this
pathogen will open new avenues for battling the entry and spread of this pathogen
in vulnerable patient groups.
AN - rayyan-563562625
AU - Priyadharsini, J. V.
AU - Girija, A. S. S.
AU - Paramasivam, A.
DO - 10.1016/j.heliyon.2018.e01051
IS - 12
PY - 2018
SN - 2405-8440
ST - An insight into the emergence of Acinetobacter baumannii as an oro-dental
pathogen and its drug resistance gene profile - An in silico approach
T2 - HELIYON
TI - An insight into the emergence of Acinetobacter baumannii as an oro-dental
pathogen and its drug resistance gene profile - An in silico approach
VL - 4
Y2 - 12
ID - 15999
ER -
TY - JOUR
AB - The main goal of this study was to develop a controlled release periodontal
formulation of Secnidazole Serratiopeptidase that can be used in the treatment of
periodontitis by direct intrapocket administration, thus ensuring a high effective
concentration of antimicrobial agent at the site of infection. This minimizes the
occurrence of systemic side effects and bacterial resistance. Serratiopeptidase, a
proteolytic enzyme with anti-inflammatory activity, is widely used in dental
treatment. The topical use of enzymes is also associated with a significant
increase in the concentration of antibiotic at the wound and decrease in the rate
of infection. Therefore, localized delivery of the enzyme along with antibiotic may
provide better relief than antibiotic alone. The pH sensitive and mucoadhesive
formulations consist of non-toxic polymer, Sodium alginate (1%), HPMC E50Lv (1-
8%w/w). To modulate the gel strength and the bioadhesive force of gel HPMC E50Lv
was used as viscosity enhancer. Viscosity studies indicated pseudo plastic (shear
thinning) behavior of gel. Increase in polymer concentration showed increase in the
viscosity thereby affecting the drug release. Dissolution studies demonstrate
diffusion release of drug and enzyme from the gel thus alginate/HPMC gels can be
used as an in-situ gelling vehicle to enhance periodontal drug delivery.
AN - rayyan-563560583
AU - Priyanka, M.
AU - Meenakshi, B.
IS - 3
KW - alginic acid
secnidazole
serratiopeptidase
article
drug solubility
gel
periodontal pocket
viscosity
LA - English
PY - 2011
SN - 0974-4304
SP - 1488-1494
ST - Study of secnidazole-serratiopeptidase alginate/HPMC gels for periodontal
delivery
TI - Study of secnidazole-serratiopeptidase alginate/HPMC gels for periodontal
delivery
VL - 3
ID - 13957
ER -
TY - JOUR
AB - BACKGROUND: The present clinical trial was designed to investigate the
effectiveness of subgingivally delivered satranidazole (SZ) gel as an adjunct to
scaling and root planing (SRP) in the treatment of chronic periodontitis. METHODS:
Sixty-four subjects with probing depth (PD) ≥ 5 mm and who were diagnosed with type
2 diabetes were selected. Thirty-two subjects each were randomly assigned to SRP +
placebo (Group 1) and SRP + SZ (Group 2). The clinical outcomes evaluated were
plaque index (PI), gingival index (GI), clinical attachment level (CAL) and PD at
baseline, 1 month, 3-months and 6 months. RESULTS: At 6 months, Group 2 had greater
mean reduction (4.73 mm) in PD as compared to Group 1 (2.09 mm; p < 0.05) and also
a greater mean CAL gain (3.92 mm versus 1.64 mm; p < 0.05). CONCLUSION: The use of
3% SZ gel, when used as an adjunct to non-surgical periodontal therapy in subjects
with periodontitis, achieves significantly better clinical results than initial
periodontal treatment alone.
AN - rayyan-563560387
AU - Priyanka, N.
AU - Kalra, N.
AU - Saquib, S.
AU - Malgaonkar, N.
AU - Nikhil, M.
AU - Tarakji, B.
AU - Varsha, J.
AU - Umashree, D.
AU - Pradeep, A. R.
IS - 2
gel
nitroimidazole derivative
placebo
satranidazole
adult
chemistry
comparative study
complication
controlled study
female
follow up
gingivitis
human
male
middle aged
periodontal disease
periodontal pocket
periodontics
procedures
tooth plaque
treatment outcome
LA - English
PY - 2015
SN - 1466-2094
SP - 42-48
ST - Efficacy of Subgingivally Delivered Satranidazole in the Treatment of Type 2
Diabetes Subjects with Chronic Periodontitis: A Randomized Controlled Clinical
Trial
TI - Efficacy of Subgingivally Delivered Satranidazole in the Treatment of Type 2
Diabetes Subjects with Chronic Periodontitis: A Randomized Controlled Clinical
Trial
VL - 17
ID - 13761
ER -
TY - JOUR
AB - Reactive oxygen species (ROS) scavengers have not been widely used for
treatment of local inflammatory reactions such as arthritis and periodontal disease
because they are rapidly eliminated from the inflamed site, which results in a low
therapeutic effect. Therefore, to enhance the local retention time of ROS
scavengers, we developed a redox-active injectable gel (RIG) system by using
poly[4-(2,2,6,6-tetramethylpiperidine-N-oxyl)aminomethylstyrene]-b- poly(ethylene
glycol)-b-poly[4-(2,2,6,6-tetramethylpiperidine-N-oxyl) aminomethylstyrene] (PMNT-
PEG-PMNT) triblock copolymer, which possesses ROS scavenging nitroxide radicals as
side chains of the PMNT segment. Cationic PMNT segment in PMNT-PEG-PMNT forms
polyion complexes with anionic poly(acrylic acid) (PAAc) to form a flower-like
micelle (ca. 79 nm), which exhibits in situ thermo-irreversible gelation under
physiological conditions. We confirmed the prolonged site-specific retention time
of RIG by performing in vivo noninvasive electron spin resonance imaging and
quantitative evaluation. In contrast to low-molecular-weight nitroxide radical
compounds that disappeared from injection sites in less than 1 h after subcutaneous
injection, 40% of the RIG remained even at 3 days. We also found that RIG inhibits
neutrophil infiltration and cytokine production, which leads to suppression of
hyperalgesia. These findings indicate the potential of RIG as an innovative
approach for treatment of local inflammation. © 2013 Elsevier B.V.
AN - rayyan-563560466
AU - Pua, M. L.
AU - Yoshitomi, T.
AU - Chonpathompikunlert, P.
AU - Hirayama, A.
AU - Nagasaki, Y.
DO - 10.1016/j.jconrel.2013.10.009
IS - 3
antioxidant
carrageenan
copolymer
poly[4 (2,2,6,6 tetramethylpiperidin n oxyl)aminomethylstyrene] b poly(ethylene
glycol) b poly[4 (2,2,6,6 tetramethylpiperidin n oxyl)aminomethylstyrene]
polyacrylic acid
unclassified drug
animal experiment
animal model
article
biocompatibility
controlled study
cytokine production
drug retention
gel
gelation
heat sensitivity
hydrogel
hyperalgesia
in vitro study
inflammation
injection site
male
micelle
mouse
non invasive procedure
nonhuman
priority journal
redox active injectable gel
zeta potential
LA - English
PY - 2013
SN - ["0168-3659", "1873-4995"]
SP - 914-920
ST - Redox-active injectable gel using thermo-responsive nanoscale polyion complex
flower micelle for noninvasive treatment of local inflammation
TI - Redox-active injectable gel using thermo-responsive nanoscale polyion complex
flower micelle for noninvasive treatment of local inflammation
VL - 172
ID - 13840
ER -
TY - JOUR
AB - The drug chlorhexidine has been widely utilized as a wound antiseptic and
oral antimicrobial rinse. There have been numerous reports on its safety as an oral
rinse, but its effects on wound healing have been contradictory. The present study
utilized human fibroblasts derived from skin and oral tissues to test the effects
of chlorhexidine on viability, growth, collagen gel contractions, and total protein
synthesis. Cells were exposed for an hour to 0.005% and 0.002% chlorhexidine and
for 30 seconds to 0.12% chlorhexidine. Our results indicate that a 0.002%
concentration of the drug shows minimal cytotoxicity, but is able to suppress cell
division almost completely. Collagen gel contraction, as a model of wound
contraction, was also severely affected by all of the concentrations of
chlorhexidine used. Total protein synthesis was suppressed by chlorhexidine in
collagen gel culture. The data support the hypothesis that chlorhexidine is highly
cytotoxic to cells in vitro, but various cell functions such as proliferation,
collagen gel contraction, and protein synthesis are affected to different degrees
by the drug.
AN - rayyan-563561354
AU - Pucher, J. J.
AU - Daniel, J. C.
DO - 10.1902/jop.1992.63.6.526
IS - 6
J2 - J Periodontol
KW - Cell Survival/drug effects
Cells, Cultured/drug effects/metabolism
Chlorhexidine/*analogs & derivatives/pharmacology
Collagen/biosynthesis/drug effects
Fibroblasts/*drug effects/metabolism
Gels
Gingiva/cytology/drug effects/metabolism
Humans
Periodontal Ligament/cytology/drug effects/metabolism
Skin/cytology/drug effects/metabolism
LA - eng
N1 - College of Dentistry, Department of Histology, University of Illinois,
Chicago.
PY - 1992
SN - 0022-3492 (Print)
SP - 526-32
ST - The effects of chlorhexidine digluconate on human fibroblasts in vitro
TI - The effects of chlorhexidine digluconate on human fibroblasts in vitro
VL - 63
Y2 - 6
ID - 14728
ER -
TY - JOUR
AB - BACKGROUND: Curcumin has anti-inflammatory properties. The aim of this study
was to compare interleukin-1β (IL-1β) and chemokine (C-C motif) ligand 28 (CCL28)
levels following a topical application of curcumin (CRM), chlorhexidine (CHX) and
chlorhexidine-metronidazole (CHX-MTZ) in an experimental gingivitis human model.
METHODS: Sixty systemically healthy selected subjects were randomly assigned to one
of three topical antigingivitis gels. Each gel was applied twice daily for 10
minutes as the sole method of oral hygiene for 29 days on the test quadrant only.
Modified gingival index (MGI), plaque index (PI), bleeding on probing (BOP) and
probing depth (PD) were assessed at baseline, 29 days and 60 days. Estimation of
IL-1β and CCL28 levels in gingival crevicular fluid was done at baseline and at 29
days. RESULTS: The increase of IL-1β in the CRM (14.52 ± 16.6 pg/ml) and CHX-MTZ
(31.63 ± 15.96) groups was significantly less than that of the CHX group (70.55 ±
38.81). Similar results were also observed for CCL28 (CRM: 8.12 ± 8.78 pg/ml; CHX-
MTZ: 12.81 ± 18.68; CHX: 41.15 ± 22.82). All groups had a significant increase in
MGI, PI and BOP at 29 days. CONCLUSIONS: The anti-inflammatory potential of topical
curcumin was similar to CHX-MTZ but superior to CHX in affecting IL-1β and CCL28
levels.
AN - rayyan-563560375
AU - Pulikkotil, S. J.
AU - Nath, S.
DO - 10.1111/adj.12340
IS - 3
beta chemokine
CCL28 protein, human
chlorhexidine
curcumin
drug combination
interleukin 1beta
metronidazole
adolescent
adult
chemistry
comparative study
controlled study
drug effect
female
follow up
gingivitis
human
male
periodontal index
periodontal pocket
plaque index
treatment outcome
young adult
LA - English
PY - 2015
SN - 1834-7819
SP - 317-327
ST - Effects of curcumin on crevicular levels of IL-1β and CCL28 in experimental
gingivitis
T2 - Aust Dent J
TI - Effects of curcumin on crevicular levels of IL-1β and CCL28 in experimental
gingivitis
VL - 60
ID - 13749
ER -
TY - JOUR
AN - rayyan-563561821
AU - Puppi, D.
AU - Migone, C.
AU - Grassi, L.
AU - Pirosa, A.
AU - Maisetta, G.
AU - Batoni, G.
AU - Chiellini, F.
DO - 10.1002/pi.5101
IS - 6
PY - 2016
SP - 631-640
ST - Integrated three-dimensional fiber/hydrogel biphasic scaffolds for
periodontal bone tissue engineering
T2 - Polymer International
TI - Integrated three-dimensional fiber/hydrogel biphasic scaffolds for
periodontal bone tissue engineering
84979468717&doi=10.1002%2fpi.5101&partnerID=40&md5=8a08d2ee78671414ed19a1da0a3aaede
VL - 65
ID - 15195
ER -
TY - JOUR
AB - Introduction: Ginger and honey have shown to be effective against pathogens
routinely encountered in periodontal infection. However, none of literature has
shown antibacterial effect of ginger and honey on the levels of dental plaque when
used as a gel. Aim: To compare the effect of honey with ginger extract on the
dental plaque levels and gingival health. Methodology: Fifteen systemically healthy
patients were randomly allocated to either the test group [G1(ginger and honey gel
= 15 sites)] or the control group [G2 (Chlorhexidine gel = 15 sites]. Full mouth
Gingival Index (GI) Full mouth Plaque Index (PI) were evaluated at baseline and on
7th day. Results: The mean PI at baseline was 0.23 +/- 0.02 (G1) and 0.29 +/- 0.01
(G2) which was increased to 0.36 +/- 0.01 (G1) and 0.37 +/- 0.01 (G2) on 7th day.
However, mean GI at baseline was 0.30 +/- 0.04 (G1) and 0.34 +/- 0.02 (G2) which
was increased to 0.38 +/- 0.03 (G1) and 0.43 +/- 0.03 (G2) on 7th day. Conclusion:
The results of this study suggest that the chlorhexidine gel and Natural gel
containing Honey and Zingibar officinale both are effective in controlling plaque
during the periodontal maintenance period.
AN - rayyan-563562360
AU - Puri, S.
AU - Bele, R.
AU - Shewale, A.
AU - Malik, R.
DO - 10.9734/JPRI/2021/v33i32A31725
IS - 32
PY - 2021
SN - 2456-9119
SP - 134-139
ST - The effect of Topical Application of Honey Based Gel Containing Zingibar
Officinale for Non Surgical Periodontal Maintenance
T2 - JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
TI - The effect of Topical Application of Honey Based Gel Containing Zingibar
Officinale for Non Surgical Periodontal Maintenance
VL - 33
ID - 15734
ER -
TY - JOUR
AB - Introduction: Herbal antiseptic or antibiotic agents are introduced very
widely that are effective against plaque microorganisms for the healing of gingival
and periodontal tissue. However, none of literature has shown antibacterial effect
of coriandrum sativum, clove and mint on the levels of dental plaque when used as a
mouthwash. Aim: To assess the efficacy of a newly formulated mouthwash containing
Coriandrum sativum, mint and clove to reduce plaque and inflammation to maintain
the oral hygiene. Methodology: Twenty systemically healthy patients were randomly
allocated to either the test group [G1(coriandrm sativum, mint,clove = 10
patients)] or the control group [G2 (Placebo gel = 10 patients]. Full mouth
Gingival Index (GI); Full mouth Plaque Index ( PI) was evaluated at baseline and on
14 and 21st day. Result: The mean reduction in PI from 2.28 to 0.85 and 2.13 to
1.21 was noted in the experimental and control groups, respectively. The
experimental group (2.21- 0.76) comparatively showed better reduction in mean PBI
than the control group (2.17-1.29). The results obtained were statistically
significant at baseline and 14th and 21st day in all the groups. Remarkable
improvement was noted from baseline to 14th and 21st day in all the groups.
Conclusion: The encouraging results of our study suggest that the newly formulated
mouthwash containing coriandrum Sativum, mint and clove demonstrates anti-
inflammatory properties, which may be useful as an adjunctive to mechanical therapy
in the prevention and treatment of gingivitis.
AN - rayyan-563562605
AU - Puri, S.
AU - Fatema, M.
AU - Shewale, A.
AU - Bele, R.
DO - 10.9734/JPRI/2021/v33i39B32180
IS - 39
PY - 2021
SN - 2456-9119
SP - 59-63
ST - Efficacy of Herbal Mouthwash with Extracts of Coriandrum Sativum, Mint and
Clove in the Treatment of Chronic Gingivitis- A Randomized Controlled Clinical
Trial
T2 - JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
TI - Efficacy of Herbal Mouthwash with Extracts of Coriandrum Sativum, Mint and
Clove in the Treatment of Chronic Gingivitis- A Randomized Controlled Clinical
Trial
VL - 33
ID - 15979
ER -
TY - JOUR
AB - Bacterial biofilms have emerged as potential critical triggers in the
pathogenesis of bisphosphonate (BP)-related osteonecrosis of the jaw (ONJ) or
BRONJ. BRONJ lesions have shown to be heavily colonized by oral bacteria, most of
these difficult to cultivate and presents many clinical challenges. The purpose of
this study was to characterize the bacterial diversity in BRONJ lesions and to
determine host immune response. We examined tissue specimens from three cohorts
(n=30); patients with periodontal disease without a history of BP therapy (Control,
n=10), patients with periodontal disease having history of BP therapy but without
ONJ (BP, n=5) and patients with BRONJ (BRONJ, n=15). Denaturing gradient gel
electrophoresis of polymerase chain reaction (PCR)-amplified 16S rRNA gene
fragments revealed less bacterial diversity in BRONJ than BP and Control cohorts.
Sequence analysis detected six phyla with predominant affiliation to Firmicutes in
BRONJ (71.6%), BP (70.3%) and Control (59.1%). Significant differences (P<0.05) in
genera were observed, between Control/BP, Control/BRONJ and BP/BRONJ cohorts.
Enzyme-linked immunosorbent assay (ELISA) results indicated that the levels of
myeloperoxidase were significantly lower, whereas interleukin-6 and tumor necrosis
factor-alpha levels were moderately elevated in BRONJ patients as compared to
Controls. PCR array showed significant changes in BRONJ patients with
downregulation of host genes, such as nucleotide-binding oligomerization domain
containing protein 2, and cathepsin G, the key modulators for antibacterial
response and upregulation of secretory leukocyte protease inhibitor, proteinase 3
and conserved helix-loop-helix ubiquitous kinase. The results suggest that
colonization of unique bacterial communities coupled with deficient innate immune
response is likely to impact the pathogenesis of ONJ.
AN - rayyan-563560412
AU - Pushalkar, S.
AU - Li, X.
AU - Kurago, Z.
AU - Ramanathapuram, L. V.
AU - Matsumura, S.
AU - Fleisher, K. E.
AU - Glickman, R.
AU - Yan, W.
AU - Li, Y.
AU - Saxena, D.
DO - 10.1038/ijos.2014.46
IS - 4
KW - bone density conservation agent
cathepsin G
CHUK protein, human
CTSG protein, human
I kappa B kinase
IL6 protein, human
interleukin 6
myeloblastin
NOD2 protein, human
peroxidase
Actinobacteria
bacterium
Bacteroidetes
biofilm
classification
cohort analysis
down regulation
female
Fusobacteria
human
immunology
innate immunity
jaw osteonecrosis
male
microbiology
middle aged
mouth
periodontal disease
Proteobacteria
LA - English
PY - 2014
SN - 1674-2818
SP - 219-226
ST - Oral microbiota and host innate immune response in bisphosphonate-related
osteonecrosis of the jaw
T2 - Int J Oral Sci
TI - Oral microbiota and host innate immune response in bisphosphonate-related
VL - 6
ID - 13786
ER -
TY - JOUR
AB - Bacterial biofilms have emerged as potential critical triggers in the
pathogenesis of bisphosphonate (BP)-related osteonecrosis of the jaw (ONJ) or
BRONJ. BRONJ lesions have shown to be heavily colonized by oral bacteria, most of
these difficult to cultivate and presents many clinical challenges. The purpose of
this study was to characterize the bacterial diversity in BRONJ lesions and to
determine host immune response. We examined tissue specimens from three cohorts
(n=30); patients with periodontal disease without a history of BP therapy (Control,
n=10), patients with periodontal disease having history of BP therapy but without
ONJ (BP, n=5) and patients with BRONJ (BRONJ, n=15). Denaturing gradient gel
electrophoresis of polymerase chain reaction (PCR)-amplified 16S rRNA gene
fragments revealed less bacterial diversity in BRONJ than BP and Control cohorts.
Sequence analysis detected six phyla with predominant affiliation to Firmicutes in
BRONJ (71.6%), BP (70.3%) and Control (59.1%). Significant differences (P<0.05) in
genera were observed, between Control/BP, Control/BRONJ and BP/BRONJ cohorts.
Enzyme-linked immunosorbent assay (ELISA) results indicated that the levels of
myeloperoxidase were significantly lower, whereas interleukin-6 and tumor necrosis
factor-alpha levels were moderately elevated in BRONJ patients as compared to
Controls. PCR array showed significant changes in BRONJ patients with
downregulation of host genes, such as nucleotide-binding oligomerization domain
containing protein 2, and cathepsin G, the key modulators for antibacterial
response and upregulation of secretory leukocyte protease inhibitor, proteinase 3
and conserved helix-loop-helix ubiquitous kinase. The results suggest that
colonization of unique bacterial communities coupled with deficient innate immune
response is likely to impact the pathogenesis of ONJ.
AN - rayyan-563562555
AU - Pushalkar, S.
AU - Li, X.
AU - Kurago, Z.
AU - Rarnanathapuram, L. V.
AU - Matsumura, S.
AU - Fleisher, K. E.
AU - Glickman, R.
AU - Yan, W. B.
AU - Li, Y. H.
AU - Saxena, D.
DO - 10.1038/ijos.2014.46
IS - 4
PY - 2014
SN - ["1674-2818", "2049-3169"]
SP - 219-226
ST - Oral microbiota and host innate immune response in bisphosphonate-related
T2 - INTERNATIONAL JOURNAL OF ORAL SCIENCE
TI - Oral microbiota and host innate immune response in bisphosphonate-related
VL - 6
Y2 - 12
ID - 15929
ER -
TY - JOUR
AB - Background: Gingival-enlargement (GE) is enlargement of gingiva which reaches
to the tooth cervical due to inflammation or fibrotic enlargement. Gingivectomy, an
excision and incision procedure of gingival tissue for fibrotic GE patients to
eliminate pockets and restore normal gingival contour. Periodontal-dressing is a
post-gingivectomy wound-dressing to promote healing in plasticine-like form which
may cause discomfort because it stands-out on patient's gums. In addition, some
periodontal-dressing contains eugenol, causing necrosis and allergies. Therefore, a
material is needed periodontal-dressing which potentially accelerates post-
gingivectomy wound healing. Combination of Epigallocatechin-3-Gallate (EGCG) and
hyaluronic-acid (HA) is biomaterial which can be obtained easily and potentially as
antibacterial, antioxidant and anti-inflammatory in post-gingivectomy wounds and
may accelerate wound healing. Hydrogel is a crosslinking polymer in colloidal-gel
form which easily absorbs by gingiva. Purpose: to review the potential of core-
shell nanoparticles EGCG and HA as absorbable-dressings based hydrogel to
accelerate post-gingivectomy wound healing. Discussion: Gingivectomy is a lateral
wall pocket elimination procedure at GE to restore normal gingival contours. HA is
a natural polymer which is non-toxic, biodegradable, and biocompatible which may
stimulate cell migration, angiogenesis, reduce inflammation, and enhance fibroblast
proliferation. EGCG is 80% catechin in green tea which has antioxidant, anti-
inflammatory, and antibacterial effects. EGGC may induce fibroblast proliferation
in gingiva, inhibit free-radicals, also induce VEGF and FGF2. Periodontal-dressing
in hydrogel form is able to comfort patient because it is absorbable and may
maintains moist environment. Conclusion: Core-shell nanoparticle EGCG and HA
potentially to be absorbable-dressing based hydrogel to accelerate post-
gingivectomy wound healing.
AN - rayyan-563560031
AU - Puspitaningrum, M. S.
AU - Maksum, M. A.
AU - Kusumawardhani, D. P.
AU - Nugraha, A. P.
DO - 10.31838/ijpr/2021.13.01.549
IS - 1
KW - biosensor
biomaterial
core shell nanoparticle
hyaluronic acid
hydrogel
interferon
interleukin 1
interleukin 10
vasculotropin
angiogenesis
arthralgia
biocompatibility
bleeding
cell migration
cell proliferation
endothelium
fibroblast
gene targeting
gingivectomy
granulation tissue
hemostasis
homeostasis
human
hypersensitivity
inflammation
injury
macrophage
molecular interaction
myofibroblast
periodontitis
review
synovial fluid
vascular remodeling
vasoconstriction
viscoelasticity
wound healing
LA - English
PY - 2021
SN - 0975-2366
SP - 4185-4189
ST - Core-shell nanoparticle epigallocatechin-3-gallate and hyaluronic acid as
absorbable dressing based hydrogel post-gingivectomy: A review
TI - Core-shell nanoparticle epigallocatechin-3-gallate and hyaluronic acid as
absorbable dressing based hydrogel post-gingivectomy: A review
VL - 13
ID - 13405
ER -
TY - JOUR
AB - PURPOSE: To evaluate the 6-month clinical effects of one scaling and root
planing (SRP) procedure alone or combined with local administration of hydrogen
peroxide gel (with or without inclusion of doxycycline for 2 weeks) using
periodontal medicament carriers in the form of customized prescription trays for
treatment of subjects with chronic periodontitis. METHODS: Using a randomized
controlled design, 61 subjects with moderate to advanced periodontitis were
assigned to three parallel treatment groups: 1) SRP combined with prescription-tray
(Perio Tray) application of 1.7% hydrogen peroxide gel (Perio Gel) and, for the
first 2 weeks, doxycycline, 2) SRP combined with prescription-tray application of
peroxide gel, and 3) SRP alone. All subjects brushed twice daily with standard
dentifrice and toothbrush for a 4-week acclimation phase, and continued this
regimen throughout the 6-month treatment phase. Pocket probing depth (PPD) and
bleeding index (BI) were assessed on natural and restored sites at baseline and
after 2, 5, 13, and 26 weeks. SRP was performed 3 weeks after baseline. Clinical
variables were compared by ANCOVA and paired t-tests after each treatment interval,
analyzing natural and restored sites separately. RESULTS: 57 subjects completed the
trial. Analysis of pockets > 5 mm at baseline showed that mean PPD for both test
groups significantly decreased from baseline approximately 0.50 mm prior to SRP.
Two weeks following SRP, mean PPD significantly decreased from baseline by > 0.90
mm for both test groups and 0.29 mm for the control. By 26 weeks, mean PPD
decreased > 1.10 mm for both test groups compared to 0.38 mm for the SRP-only
control (P < 0.001 for test versus control at all post-SRP comparisons). Analysis
of pockets ≤ 5 mm at baseline showed the same relationship between groups (P <
0.001 for test versus control). Mean BI dropped significantly only for test groups
before SRP, and the tray/peroxide-doxycycline group was significantly different
from the control (P = 0.033). Two weeks post-SRP, mean BI reductions for test
groups were significantly greater than the control, and remained so for most
comparisons. For restored sites, mean PPDs of both test groups were significantly
better (P < 0.05) than the control for all post-baseline comparisons.
AN - rayyan-563560418
AU - Putt, M. S.
AU - Mallatt, M. E.
AU - Messmann, L. L.
AU - Proskin, H. M.
IS - 5
doxycycline
gel
hydrogen peroxide
controlled study
devices
human
periodontitis
LA - English
PY - 2014
SN - 0894-8275
SP - 273-284
ST - A 6-month clinical investigation of custom tray application of peroxide gel
with or without doxycycline as adjuncts to scaling and root planing for treatment
of periodontitis
T2 - Am J Dent
TI - A 6-month clinical investigation of custom tray application of peroxide gel
with or without doxycycline as adjuncts to scaling and root planing for treatment
of periodontitis
VL - 27
ID - 13792
ER -
TY - JOUR
AB - Periodontitis is an inflammatory condition of the supporting dental tissues
that is normally treated by mechanical removal of the subgingival biofilm. This
mechanical treatment, generally known as scaling and root planing (SRP), is not
entirely effective, and various adjunctive therapies have been investigated to
improve the clinical outcome. This study evaluated the clinical effects of SRP
alone or combined with local administration of hydrogen peroxide gel using
customized trays in the treatment of subjects with chronic periodontitis. An
examiner-blind clinical trial was conducted among 30 subjects with moderate to
advanced periodontitis, who were randomized to SRP alone or SRP combined with a
prescription custom-tray application (Perio Tray) of 1.7% hydrogen peroxide gel
(Perio Gel) for a period of three months. Following impressions for the test group,
all subjects brushed twice daily with a regular dentifrice and toothbrush for a
four-week acclimation phase to standardize oral conditions (while trays were
fabricated) prior to initiating the treatment phase. Clinical assessments, i.e.,
pocket probing depth (PPD) and bleeding index (BI), were conducted at baseline and
after two, five, and 13 weeks of peroxide applications; SRP was performed three
weeks after baseline. Clinical variables were compared by ANOVA and paired t-tests
after each treatment interval. A total of 13 test and 15 control subjects completed
the study. After two weeks of peroxide gel use prior to SRP, mean whole-mouth PPD
was unchanged for the control group, but significantly decreased 0.21 mm in the
test group. Two weeks following SRP, mean PPD decreased from baseline by 0.17 mm
for the control group and 0.65 mm for the test group. Ten weeks following SRP, mean
PPD decreases were 0.13 mm for the control group and 0.77 mm for the test group.
After two weeks of peroxide use prior to SRP, mean whole-mouth BI decreased 0.03
(from 15% to 12%) for the control and 0.14 (from 23% to 9%) for the test group. Two
weeks after SRP, the mean whole-mouth BI score decreased 0.05 from baseline (15% to
10%) for the control and 0.17 (23% to 6%) for the test group. Ten weeks after SRP,
there was no change from baseline for the control group, but BI was 0.14 lower (23%
to 9%) for the test group. Further analysis showed the same statistical
relationship between groups for PPD assessments of deeper pockets. For pockets > or
=6 mm at baseline, mean PPD decreased by 0.04 mm for the control compared to 0.48
mm for the test group after two weeks of peroxide gel use and prior to SRP. Two
weeks after SRP, mean PPD decreased from baseline by 0.60 mm for the control and
1.40 mm for the test group, and 10 weeks after SRP by 0.58 mm for the control and
1.57 mm for the test group. All reductions cited above for the test group were
statistically significantly different from the control group for both PPD and BI.
The adjunctive use over three months of 1.7% hydrogen peroxide gel, locally
administered using prescription customized trays in the treatment of subjects with
moderate to advanced periodontitis, demonstrated statistically significant clinical
improvements in pocket depths and bleeding when compared with SRP alone.
AN - rayyan-563560538
AU - Putt, M. S.
AU - Proskin, H. M.
IS - 2
adult
aged
article
clinical trial
controlled study
female
gel
human
male
middle aged
periodontal pocket
periodontics
treatment outcome
LA - English
PY - 2012
SN - 0895-8831
SP - 48-56
ST - Custom tray application of peroxide gel as an adjunct to scaling and root
planing in the treatment of periodontitis: a randomized, controlled three-month
clinical trial
T2 - J Clin Dent
TI - Custom tray application of peroxide gel as an adjunct to scaling and root
planing in the treatment of periodontitis: a randomized, controlled three-month
clinical trial
VL - 23
ID - 13912
ER -
TY - GEN
AB - Objective: Scaling and root planing (SRP) is the primary non-surgical
treatment for periodontitis, but its effectiveness is limited. Consequently,
various adjunctive therapies have been investigated to improve clinical outcome.
This study evaluated the clinical effects of one SRP procedure alone or combined
with local administration of hydrogen peroxide gel using customized trays for the
treatment of subjects with chronic periodontitis over a period of six months. •
Methods: An examiner-blind clinical trial was conducted among 30 subjects with
moderate to advanced periodontitis who were randomized to SRP alone or SRP combined
with prescription custom-tray application (Perio Tray®) of 1.7% hydrogen peroxide
gel (Perio Gel®) for a period of three months, then extended to six months.
Following impressions for the test group, all subjects brushed twice daily with a
regular dentifrice and toothbrush for a four-week acclimation phase to standardize
oral conditions (while trays were fabricated) prior to initiating the treatment
phase. SRP was performed three weeks after baseline, and clinical assessments,
i.e., pocket probing depth (PPD) and bleeding index (BI), were conducted at
baseline and after two, five, 13, and 26 weeks of peroxide gel applications.
Clinical variables were compared by ANCOVA and paired t-tests after each treatment
interval. • Results: A total of 13 test and 15 control subjects completed the
original three-month trial, of whom 10 test and 13 control subjects finished the
three-month extension. After two weeks of peroxide gel use prior to SRP, mean PPD
for the test group significantly decreased from baseline by 0.21 mm and mean BI
significantly dropped by 0.14; clinical parameters for the control group were
unchanged. Two weeks following SRP, mean PPD significantly decreased from baseline
by 0.65 mm for the test group and 0.17 mm for the control; mean BI significantly
dropped by 0.17 for the test group and 0.05 for the control. Ten weeks following
SRP, mean PPD decreases were 0.77 mm for the test group and 0.13 mm for the
control, and mean BI reductions were 0.14 for the test group and 0.00 for the
control. For subjects who completed the three-month extension (i.e., 23 weeks post-
SRP), mean PPD decreases were 0.72 mm for the test group and 0.13 mm for the
control, and mean BI reductions were 0.05 for the test group and 0.01 for the
control. Analysis of deeper pockets (i.e., > 5 mm at baseline) showed the same
relationship for PPD, but with larger differences between groups. For example,
after two weeks of peroxide gel use prior to SRP, mean PPD decreased by 0.48 mm for
the test group compared to 0.04 mm for the control. Two weeks after SRP, mean PPD
decreased from baseline by 1.40 mm for the test group and 0.60 mm for the control,
and 10 weeks after SRP by 1.57 mm for the test group and 0.58 mm for the control.
After the extension (i.e., 23 weeks post-SRP), mean PPD changed from baseline by
1.50 mm for the test group and 0.55 mm for the control. With the exception of BI at
23 weeks post-SRP, all reductions cited above for the test group were statistically
significantly different from the control group for both PPD and BI for all
comparisons. • Conclusion: When compared with SRP alone, clinical improvements in
PPD (eg., ̃1.0 mm for pockets > 5 mm at baseline) were maintained for up to six
months after SRP with adjunctive use of 1.7% hydrogen peroxide gel, locally
administered using prescription customized trays in the treatment of subjects with
moderate to advanced periodontitis.
AN - rayyan-563560507
AU - Putt, M. S.
AU - Proskin, H. M.
CY - M.S. Putt
adult
aged
article
controlled study
devices
female
human
male
middle aged
patient compliance
periodontics
LA - English
PY - 2013
SN - 0895-8831
SP - 100-107
ST - Custom tray application of peroxide gel as an adjunct to scaling and root
planing in the treatment of periodontitis: Results of a randomized controlled trial
after six months
T2 - J. Clin. Dent.
TI - Custom tray application of peroxide gel as an adjunct to scaling and root
planing in the treatment of periodontitis: Results of a randomized controlled trial
after six months
VL - 24
ID - 13881
ER -
TY - JOUR
AB - Solvent exchange-induced in situ forming gel (ISG) has emerged as a versatile
drug delivery system, particularly for periodontal pocket applications. In this
study, we developed lincomycin HCl-loaded ISGs using a 40% borneol-based matrix and
N-methyl pyrrolidone (NMP) as a solvent. The physicochemical properties and
antimicrobial activities of the ISGs were evaluated. The prepared ISGs exhibited
low viscosity and reduced surface tension, allowing for easy injection and
spreadability. Gel formation increased the contact angle on agarose gel, while
higher lincomycin HCl content decreased water tolerance and facilitated phase
separation. The drug-loading influenced solvent exchange and matrix formation,
resulting in thinner and inhomogeneous borneol matrices with slower gel formation
and lower gel hardness. The lincomycin HCl-loaded borneol-based ISGs demonstrated
sustained drug release above the minimum inhibitory concentration (MIC) for 8 days,
following Fickian diffusion and fitting well with Higuchi's equation. These
formulations exhibited dose-dependent inhibition of Staphylococcus aureus ATCC
25923, Escherichia coli ATCC 8739, and Prophyromonas gingivalis ATCC 33277, and the
release of NMP effectively inhibited Candida albicans ATCC 10231. Overall, the 7.5%
lincomycin HCl-loaded 40% borneol-based ISGs hold promise as localized drug
delivery systems for periodontitis treatment.
AN - rayyan-563560969
AU - Puyathorn, N.
AU - Chantadee, T.
AU - Phaechamud, T.
DO - 10.3390/gels9060495
IS - 6
J2 - Gels
LA - eng
N1 - Programme of Pharmaceutical Engineering, Department of Industrial Pharmacy,
Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.; Program
of Pharmaceutical Technology, Department of Industrial Pharmacy, Faculty of
Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai
Pathom 73000, Thailand.; Department of Pharmaceutical Technology, Faculty of
Pharmaceutical Sciences, Prince of Songkla University, Songkhla 90110, Thailand.;
Programme of Pharmaceutical Engineering, Department of Industrial Pharmacy, Faculty
of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.; Program of
Pharmaceutical Technology, Department of Industrial Pharmacy, Faculty of Pharmacy,
Silpakorn University, Nakhon Pathom 73000, Thailand.; Natural Bioactive and
73000, Thailand.
PY - 2023
ST - Lincomycin HCl-Loaded Borneol-Based In Situ Gel for Periodontitis Treatment
TI - Lincomycin HCl-Loaded Borneol-Based In Situ Gel for Periodontitis Treatment
VL - 9
Y2 - 6 y3 - 19
ID - 14343
ER -
TY - JOUR
AB - Modulation with the suppression of infection and inflammation is essential to
the successful treatment of periodontitis. An aqueous insoluble hydrophobic anti-
inflammatory compound, i.e., ibuprofen (IBU), was investigated in this study as the
matrix-forming agent of a doxycycline hyclate (DH)-loaded solvent removal-induced
in situ forming gel (ISG) using dimethyl sulfoxide (DMSO) and N-methyl pyrrolidone
(NMP) as the solvents. Their physicochemical properties, including pH, density,
viscosity, surface tension, contact angle, water tolerance, injectability,
mechanical properties, gel formation, and drug release, were determined. Their
antimicrobial activities were tested using agar cup diffusion, and their anti-
inflammatory activity was assessed using thermal inhibition of protein denaturation
of egg albumin. Increasing the IBU content decreased the density, pH, surface
tension, and contact angle but increased the viscosity, force and work of
injection, and gel formation of IBU-based ISG solution. Although their water
tolerance values decreased with the increase in IBU content, the addition of DH and
the use of NMP led to high water tolerance. The characterization of the dried gel
remnants of ISGs presented no change in IBU crystallinity and thermal properties
and confirmed no chemical interaction among the components of ISGs. The obtained
transformed IBU matrix prolonged the release of DH and IBU from ISGs over 7 days
from its tortuously packed IBU matrix with small pores, and conformed well with
Fickian diffusion mechanism. The developed DH-loaded solvent removal-induced IBU-
based ISGs exhibited efficient antimicrobial activities against Staphylococcus
aureus, methicillin-resistant S. aureus, Escherichia coli, Candida albicans,
Porphyromonas gingivalis, and Aggregatibacter actinomycetemcomitans. IBU in
formulation promoted the antimicrobial activity of ISGs, whereas DH and NMP
promoted the anti-inflammatory activity of ISGs. Consequently, the DH-loaded
solvent removal-induced IBU-based ISGs proposed in this study show great potential
as an effective bioactive drug delivery system for periodontitis treatment by
localized periodontal pocket injection.
AN - rayyan-563561246
AU - Puyathorn, N.
AU - Senarat, S.
AU - Phaechamud, T.
DO - 10.3390/gels9020128
IS - 2
J2 - Gels
LA - eng
University, Nakhon Pathom 73000, Thailand.; Programme of Pharmaceutical
Engineering, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000,
Thailand.; Program of Pharmaceutical Technology, Department of Pharmaceutical
Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000,
Thailand.; Programme of Pharmaceutical Engineering, Faculty of Pharmacy, Silpakorn
University, Nakhon Pathom 73000, Thailand.; Department of Industrial Pharmacy,
Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.; Natural
Bioactive and Material for Health Promotion and Drug Delivery System Group (NBM),
Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.
PY - 2023
ST - Physicochemical and Bioactivity Characteristics of Doxycycline Hyclate-Loaded
Solvent Removal-Induced Ibuprofen-Based In Situ Forming Gel
TI - Physicochemical and Bioactivity Characteristics of Doxycycline Hyclate-Loaded
Solvent Removal-Induced Ibuprofen-Based In Situ Forming Gel
VL - 9
Y2 - 2 y3 - 3
ID - 14620
ER -
TY - JOUR
AB - Purpose: To clinically evaluate and compare the efficacy of indocyanine green
mediated photodynamic therapy (PDT) and aloe vera (AV) gel when used as adjunct
therapy to scaling and root planing (SRP) for treatment of chronic periodontitis.
Materials and Methods: One hundred fifty patients were randomly assigned to three
treatment groups: group 1 (SRP), group 2 (SRP+PDT) and group 3 (SRP+AV). Four
clinical parameters - plaque index (PI), bleeding on probing (BoP), periodontal
(PD) pocket depth and clinical attachment level (CAL) - were evaluated at baseline
and 3 and 6 months post treatment. Additionally, the amount of three inflammatory -
cytokines IL-6, IL-8 and TNF-a - in gingival crevicular fluid (GCF) was identified
using an enzyme-linked immune-sorbent assay (ELISA). Result: Statistically
significant improvement was observed for all clinical parameters in group 3 at
follow-up in comparison to groups 1 and 2. Individuals treated with adjunct PDT
showed statistically significant reduction in moderate (4-5 mm) and deep (>_6 mm)
PD pockets at the 3-month follow-up. Group-2 and -3 patients displayed
statistically significant reductions in cytokines IL-6, IL-8 and TNF-a at the 3-
month follow-up in comparison to group 1 patients. This reduction in cytokines was
maintained at the 6-month follow-up. Conclusion: Adjunct treatment regimens PDT and
AV gel statistically significantly contributed to decreasing inflammation in
periodontal tissue. AV /gel showed potential to decrease BoF whereas PDT can
facilitate increasing the
AN - rayyan-563562318
AU - Qamara, Z.
AU - Almohanab, S. A.
AU - Alanazib, A. K.
AU - Almohanab, A. A.
AU - Zeeshand, T.
DO - 10.3290/j.ohpd.b2082037
IS - 1
PY - 2021
SN - ["1602-1622", "1757-9996"]
SP - 489-494
ST - Clinical Evaluation of the Effects of Topical Indocyanine-green Mediated
Photosensitiser vs Aloe Vera Gel as Adjunct Therapy to Scaling and Root Planing in
T2 - ORAL HEALTH & PREVENTIVE DENTISTRY
TI - Clinical Evaluation of the Effects of Topical Indocyanine-green Mediated
Photosensitiser vs Aloe Vera Gel as Adjunct Therapy to Scaling and Root Planing in
VL - 19
ID - 15692
ER -
TY - JOUR
AB - Periodontitis is one of the most prevalent chronic inflammatory diseases and
Polyphenols isolated from Turkish gall play a major role in the treatment of
inflammatory diseases for their antibacterial, anti-inflammatory and antioxidant
activities. In this work, Turkish Galls effective constituent (TGEC, T) was
prepared into nanoparticles (T-NPs) by principle of oxidative self-polymerization.
The pH-sensitive T-NPs was encapsulated into thermosensitive type in-situ hydrogel,
and 42.29 +/- 1.12% of effective constituent from T-NPs were continuously released
within 96 h under the periodontitis environment. In addition, the weakly alkaline
oral micro-environment of patients with periodontitis is more conducive to the
sustained release of effective constituent, which is 10.83% more than that of
healthy periodontal environment. The bacteriostatic test showed that T-NPs had
stronger antibacterial activity on oral pathogens than that of TGEC. Compared with
TGEC, the minimum inhibitory concentration (MIC) of T-NPs against P. gingivalis and
A. viscosus was reduced by 50% and 25%, respectively. Interestingly, T-NPs induced
bacteria lysis by promoting the excessive production of ROS without periodontal
tissue damage caused by excessive oxidation reaction. In conclusion, a simple
method of preparing microspheres with natural polyphenols was developed, which
provides beneficial reference for one-step prepared drug carriers from effective
components of natural product, likewise the method offers a green and effective
solution to synthesis a new adjuvant therapy drugs for treatment of gingivitis
associated with periodontal pockets.
AN - rayyan-563562314
AU - Qi, Y. Y.
AU - Yang, J. X.
AU - Chi, Y. P.
AU - Wen, P.
AU - Wang, Z. Y.
AU - Yu, S. Y.
AU - Xue, R.
AU - Fan, J. M.
AU - Li, H.
AU - Chen, W.
AU - Wang, X. J.
AU - Zhang, Y.
AU - Guo, G.
AU - Han, B.
DO - 10.1186/s43556-022-00082-3
IS - 1
PY - 2022
SN - 2662-8651
ST - Natural polyphenol self-assembled pH-responsive nanoparticles loaded into
reversible hydrogel to inhibit oral bacterial activity
T2 - MOLECULAR BIOMEDICINE
TI - Natural polyphenol self-assembled pH-responsive nanoparticles loaded into
VL - 3
Y2 - 9 y3 - 16
ID - 15688
ER -
TY - JOUR
AN - rayyan-563560095
AU - Qi, Y.
AU - Dai, R.
DO - 10.1111/odi.13448
IS - 6
bronchoalveolar lavage fluid
disease association
health
human
letter
lung
metagenomics
periodontitis
pneumonia
priority journal
tooth plaque
LA - English
PY - 2020
SN - ["1601-0825", "1354-523X"]
SP - 1349-1350
ST - Another evidence of the Oral–Lung Axis: Oral health as a determinant of lung
health
T2 - Oral Dis.
TI - Another evidence of the Oral–Lung Axis: Oral health as a determinant of lung
health
VL - 26
ID - 13469
ER -
TY - JOUR
AB - Periodontitis is one of the most prevalent chronic inflammatory diseases and
Polyphenols isolated from Turkish gall play a major role in the treatment of
inflammatory diseases for their antibacterial, anti-inflammatory and antioxidant
activities. In this work, Turkish Galls effective constituent (TGEC, T) was
prepared into nanoparticles (T-NPs) by principle of oxidative self-polymerization.
The pH-sensitive T-NPs was encapsulated into thermosensitive type in-situ hydrogel,
and 42.29 ± 1.12% of effective constituent from T-NPs were continuously released
within 96 h under the periodontitis environment. In addition, the weakly alkaline
oral micro-environment of patients with periodontitis is more conducive to the
sustained release of effective constituent, which is 10.83% more than that of
healthy periodontal environment. The bacteriostatic test showed that T-NPs had
stronger antibacterial activity on oral pathogens than that of TGEC. Compared with
TGEC, the minimum inhibitory concentration (MIC) of T-NPs against P. gingivalis and
A. viscosus was reduced by 50% and 25%, respectively. Interestingly, T-NPs induced
bacteria lysis by promoting the excessive production of ROS without periodontal
tissue damage caused by excessive oxidation reaction. In conclusion, a simple
method of preparing microspheres with natural polyphenols was developed, which
provides beneficial reference for one-step prepared drug carriers from effective
components of natural product, likewise the method offers a green and effective
solution to synthesis a new adjuvant therapy drugs for treatment of gingivitis
associated with periodontal pockets.
AN - rayyan-563561292
AU - Qi, Y.
AU - Yang, J.
AU - Chi, Y.
AU - Wen, P.
AU - Wang, Z.
AU - Yu, S.
AU - Xue, R.
AU - Fan, J.
AU - Li, H.
AU - Chen, W.
AU - Wang, X.
AU - Zhang, Y.
AU - Guo, G.
AU - Han, B.
DO - 10.1186/s43556-022-00082-3
IS - 1
J2 - Mol Biomed
LA - eng
N1 - School of Pharmacy/School of Food science/Key Laboratory of Xinjiang
Phytomedicine Resource and Utilization, Ministry of Education, Shihezi University,
Xinjiang, Shihezi, 832002, PR China.; Department of Pharmacy, Karamay Central
Hospital, Karamay, 834000, PR China.; School of Pharmacy/School of Food science/Key
Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of
Education, Shihezi University, Xinjiang, Shihezi, 832002, PR China.; School of
Pharmacy/School of Food science/Key Laboratory of Xinjiang Phytomedicine Resource
and Utilization, Ministry of Education, Shihezi University, Xinjiang, Shihezi,
832002, PR China.; School of Pharmacy/School of Food science/Key Laboratory of
Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Shihezi
University, Xinjiang, Shihezi, 832002, PR China.; School of Pharmacy/School of Food
science/Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry
of Education, Shihezi University, Xinjiang, Shihezi, 832002, PR China.; School of
University, Xinjiang, Shihezi, 832002, PR China.; School of Pharmacy/School of Food
science/Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry
of Education, Shihezi University, Xinjiang, Shihezi, 832002, PR China.; School of
University, Xinjiang, Shihezi, 832002, PR China.; State Key Laboratory of
Biotherapy and Cancer Center, and Department of Otorhinolaryngology, Head and Neck
Surgery, West China Hospital, Sichuan University, and Collaborative Innovation
Center for Biotherapy, Chengdu, 610041, PR China.; School of Pharmacy/School of
Food science/Key Laboratory of Xinjiang Phytomedicine Resource and Utilization,
Ministry of Education, Shihezi University, Xinjiang, Shihezi, 832002, PR China.
zhangyanzqgh@163.com.; State Key Laboratory of Biotherapy and Cancer Center, and
Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital,
Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu,
610041, PR China. aipingtong@scu.edu.cn.; Sinopharm Xinjiang Pharmaceutical Co.,
Ltd, Urumqi, 830000, PR China. aipingtong@scu.edu.cn.; School of Pharmacy/School of
Food science/Key Laboratory of Xinjiang Phytomedicine Resource and Utilization,
Ministry of Education, Shihezi University, Xinjiang, Shihezi, 832002, PR China.
524683221@qq.com.; State Key Laboratory of Biotherapy and Cancer Center, and
Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital,
Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu,
610041, PR China. 524683221@qq.com.
PY - 2022
SP - 28
ST - Natural polyphenol self-assembled pH-responsive nanoparticles loaded into
T2 - Molecular biomedicine
TI - Natural polyphenol self-assembled pH-responsive nanoparticles loaded into
VL - 3
Y2 - 9 y3 - 16
ID - 14666
ER -
TY - JOUR
AB - Periodontitis is caused by periodontopathic bacteria and antibacterial agents
are placed in a periodontal pocket with the intention of enhancing the local
effect. To maximize the therapeutic effects while reducing the adverse effects,
tinidazole was delivered by in situ forming system. One approach for reducing burst
release rate was to testify in situ forming effect. The effect of 0%10% (w/w)
polyethylene glycol 400 and 3% (w/w) glycerol on the tinidazole release from a
poly(DL-lactide) (PLA) injectable implant was evaluated. The results showed that
the in vitro initial burst release rate was decreased in the presence of
poly(ethyleneglycol) PEG 400 and glycerol. A formulation containing 30% (w/w) PLA
(Mw 7300) dissolved in 62% (w/w) N-methyl-2-pyrrolidone, 5% (w/w) PEG 400, and 3%
(w/w) glycerol with 5% (w/w) tinidazole was shown to be optimum. Twelve adult
beagle dogs were used in the periodontitis model. The treatment group I, II, and
positive control group was administrated with gel containing 5%(w/w) tinidazole,
2.5%(w/w) tinidazole, and periocline, respectively. Dog studies revealed that
periocline and the developed formulation could significantly decrease symptoms of
periodontitis, and they were better than gel containing 2.5% (w/w) tinidazole. The
developed formulation could sustain the release of tinidazole for local delivery
over 7 days. These findings suggested that the developed formulation was a viable
alternative to conventional drug to cure periodontitis. (c) 2012 Wiley Periodicals,
Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
AN - rayyan-563562319
AU - Qin, Y. Y.
AU - Yuan, M. L.
AU - Li, L.
AU - Li, W.
AU - Xue, J.
DO - 10.1002/jbm.b.32788
IS - 8
PY - 2012
SN - ["1552-4973", "1552-4981"]
SP - 2197-2202
ST - Formulation and evaluation of in situ forming PLA implant containing
tinidazole for the treatment of periodontitis
TI - Formulation and evaluation of in situ forming PLA implant containing
VL - 100
Y2 - 11
ID - 15693
ER -
TY - JOUR
AB - Periodontitis is caused by periodontopathic bacteria and antibacterial agents
are placed in a periodontal pocket with the intention of enhancing the local
effect. To maximize the therapeutic effects while reducing the adverse effects,
tinidazole was delivered by in situ forming system. One approach for reducing burst
release rate was to testify in situ forming effect. The effect of 0%-10% (w/w)
polyethylene glycol 400 and 3% (w/w) glycerol on the tinidazole release from a
poly(DL-lactide) (PLA) injectable implant was evaluated. The results showed that
the in vitro initial burst release rate was decreased in the presence of
poly(ethyleneglycol) PEG 400 and glycerol. A formulation containing 30% (w/w) PLA
(M(w) 7300) dissolved in 62% (w/w) N-methyl-2-pyrrolidone, 5% (w/w) PEG 400, and 3%
(w/w) glycerol with 5% (w/w) tinidazole was shown to be optimum. Twelve adult
beagle dogs were used in the periodontitis model. The treatment group I, II, and
positive control group was administrated with gel containing 5%(w/w) tinidazole,
2.5%(w/w) tinidazole, and periocline, respectively. Dog studies revealed that
periocline and the developed formulation could significantly decrease symptoms of
periodontitis, and they were better than gel containing 2.5% (w/w) tinidazole. The
developed formulation could sustain the release of tinidazole for local delivery
over 7 days. These findings suggested that the developed formulation was a viable
alternative to conventional drug to cure periodontitis. Copyright © 2012 Wiley
Periodicals, Inc.
AN - rayyan-563560521
AU - Qin, Y.
AU - Yuan, M.
AU - Li, L.
AU - Li, W.
AU - Xue, J.
IS - 8
KW - antitrichomonal agent
polyester
polylactide
tinidazole
animal
article
chemistry
dog
human
periodontitis
tooth implant
LA - English
PY - 2012
SN - 1552-4981
SP - 2197-2202
ST - Formulation and evaluation of in situ forming PLA implant containing
TI - Formulation and evaluation of in situ forming PLA implant containing
VL - 100
ID - 13895
ER -
TY - JOUR
AB - Infectious bone defects remain a significant challenge in orthopedics and
dentistry. Calcium phosphate cement (CPC) have attracted significant interest in
use as local drug delivery system, which with great potential to control release of
antibiotics for the treatment of infectious bone defects. Within the current study,
a novel antibacterial scaffold of chitosan-reinforced calcium phosphate cement
delivering doxycycline hyclate (CPCC + DOX) was developed. Furthermore, the
capacity of CPCC + DOX scaffolds for bone regeneration was enhanced by the human
periodontal ligament stem cells (hPDLSCs) encapsulated in alginate beads. CPCC +
DOX scaffolds were fabricated to contain different concentrations of DOX. Flexural
strength of CPCC + DOX ranged from 5.56 +/- 0.70 to 6.2 +/- 0.72 MPa, which
exceeded the reported strength of cancellous bone. Scaffolds exhibited continual
DOX release, reaching 80% at 21 days. Scaffold with 5 mg/ml DOX (CPCC + DOX5mg) had
a strong antibacterial effect, with a 4-log colony forming unit reduction against
S. aureus and P. gingivalis. The proliferation and osteogenic differentiation of
hPDLSCs encapsulated in alginate hydrogel microbeads were investigated in culture
with CPCC + DOX scaffolds. CPCC + DOX5mg had no negative effect on proliferation of
hPDLSCs. Alkaline phosphatase activity, mineral synthesis, and osteogenic gene
expressions for CPCC + DOX5mg group were much higher than control group. DOX did
not compromise the osteogenic induction. In summary, the novel CPCC + DOX scaffold
exhibited excellent mechanical properties and strong antibacterial activity, while
supporting the proliferation and osteogenic differentiation of hPDLSCs. The CPCC +
DOX + hPDLSCs construct is promising to enhance bone regeneration and combat bone
infections in dental, craniofacial, and orthopedic applications.
AN - rayyan-563562263
AU - Qiu, G. T.
AU - Huang, M. G.
AU - Liu, J.
AU - Wang, P.
AU - Schneider, A.
AU - Ren, K.
AU - Oates, T. W.
AU - Weir, M. D.
AU - Xu, H. H. K.
AU - Zhao, L.
DO - 10.1002/term.3169
IS - 3
PY - 2021
SN - ["1932-6254", "1932-7005"]
SP - 232-243
ST - Antibacterial calcium phosphate cement with human periodontal ligament stem
cell-microbeads to enhance bone regeneration and combat infection
T2 - JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
TI - Antibacterial calcium phosphate cement with human periodontal ligament stem
VL - 15
Y2 - 3
ID - 15637
ER -
TY - JOUR
AB - Infectious bone defects remain a significant challenge in orthopedics and
dentistry. Calcium phosphate cement (CPC) have attracted significant interest in
use as local drug delivery system, which with great potential to control release of
antibiotics for the treatment of infectious bone defects. Within the current study,
a novel antibacterial scaffold of chitosan-reinforced calcium phosphate cement
delivering doxycycline hyclate (CPCC + DOX) was developed. Furthermore, the
capacity of CPCC + DOX scaffolds for bone regeneration was enhanced by the human
periodontal ligament stem cells (hPDLSCs) encapsulated in alginate beads. CPCC +
DOX scaffolds were fabricated to contain different concentrations of DOX. Flexural
strength of CPCC + DOX ranged from 5.56 ± 0.70 to 6.2 ± 0.72 MPa, which exceeded
the reported strength of cancellous bone. Scaffolds exhibited continual DOX
release, reaching 80% at 21 days. Scaffold with 5 mg/ml DOX (CPCC + DOX5mg) had a
strong antibacterial effect, with a 4-log colony forming unit reduction against S.
aureus and P. gingivalis. The proliferation and osteogenic differentiation of
hPDLSCs encapsulated in alginate hydrogel microbeads were investigated in culture
with CPCC + DOX scaffolds. CPCC + DOX5mg had no negative effect on proliferation of
hPDLSCs. Alkaline phosphatase activity, mineral synthesis, and osteogenic gene
expressions for CPCC + DOX5mg group were much higher than control group. DOX did
not compromise the osteogenic induction. In summary, the novel CPCC + DOX scaffold
exhibited excellent mechanical properties and strong antibacterial activity, while
supporting the proliferation and osteogenic differentiation of hPDLSCs. The CPCC +
DOX + hPDLSCs construct is promising to enhance bone regeneration and combat bone
infections in dental, craniofacial, and orthopedic applications.
AN - rayyan-563560016
AU - Qiu, G.
AU - Huang, M.
AU - Liu, J.
AU - Wang, P.
AU - Schneider, A.
AU - Ren, K.
AU - Oates, T. W.
AU - Weir, M. D.
AU - Xu, H. H. K.
AU - Zhao, L.
DO - 10.1002/term.3169
IS - 3
KW - alginate hydrogel microbead
alginic acid
calcium phosphate
calcium phosphate cement
cement
chitosan
doxycycline hyclate
drug carrier
hydrogel
unclassified drug
adult
article
bone development
bone infection
bone mineral
bone regeneration
cell encapsulation
cell viability
colony forming unit
controlled study
drug formulation
drug release
enzyme activity
flexural strength
gene expression
human
human cell
human periodontal ligament stem cell
human tissue
ligament
nonhuman
periodontium
stem cell
stem cell culture
stem cell transplantation
synthesis
tooth infection
trabecular bone
LA - English
PY - 2021
SN - ["1932-7005", "1932-6254"]
SP - 232-243
ST - Antibacterial calcium phosphate cement with human periodontal ligament stem
T2 - J. Tissue Eng. Regen. Med.
TI - Antibacterial calcium phosphate cement with human periodontal ligament stem
VL - 15
ID - 13390
ER -
TY - JOUR
AB - "Medicine food homology" (MFH) is a term with a lengthy history. It refers to
the fact that a lot of traditional natural products have both culinary and
therapeutic benefits. The antibacterial, anti-inflammatory and anticancer effects
of MFH plants and their secondary metabolites have been confirmed by numerous
research. A bacterially generated inflammatory illness with a complicated
pathophysiology, periodontitis causes the loss of the teeth's supporting tissues.
Several MFH plants have recently been shown to have the ability to prevent and
treat periodontitis, which is exhibited by blocking the disease's pathogens and the
virulence factors that go along with them, lowering the host's inflammatory
reactions and halting the loss of alveolar bone. To give a theoretical foundation
for the creation of functional foods, oral care products and adjuvant therapies,
this review has especially explored the potential medicinal benefit of MFH plants
and their secondary metabolites in the prevention and treatment of periodontitis.
AN - rayyan-563562295
AU - Qu, S. L.
AU - Yu, S.
AU - Ma, X. L.
AU - Wang, R.
DO - 10.3389/fnut.2023.1193289
PY - 2023
SN - 2296-861X
ST - "Medicine food homology" plants promote periodontal health: antimicrobial,
anti-inflammatory, and inhibition of bone resorption
T2 - FRONTIERS IN NUTRITION
TI - "Medicine food homology" plants promote periodontal health: antimicrobial,
anti-inflammatory, and inhibition of bone resorption
VL - 10
Y2 - 6 y3 - 15
ID - 15669
ER -
TY - JOUR
AB - In a standard periodontal treatment strategy with consecutive root planings
(per quadrant at a one- to two-week interval), re-infection of a disinfected area
might occur before completion of the treatment. This study examines, both
clinically and microbiologically, whether a full-mouth disinfection within 24 hours
significantly improves the outcome of periodontal treatment. Ten patients with
advanced chronic periodontitis were randomly allocated to a test and a control
group. The patients from the control group received scalings and root planings as
well as oral hygiene instructions per quadrant at two-week intervals. Full-mouth
disinfection in the test group was sought by the removal of all plaque and calculus
(in two visits within 24 hours). In addition, at each of these visits, the tongue
was brushed with a 1% chlorhexidine gel for one min and the mouth rinsed with a
0.2% chlorhexidine solution for two min. Furthermore, subgingival chlorhexidine
(1%) irrigation was performed in all pockets. The recolonization of the pockets was
retarded by oral hygiene and 0.2% chlorhexidine rinses during two weeks. The
clinical parameters were recorded, and plaque samples were taken from the right
upper quadrant at baseline and after one and two months. The test group patients
showed a significantly higher reduction in probing depth for deep pockets at both
follow-up visits (p < 0.05). At the one-month visit, differential phase-contrast
microscopy revealed significantly lower proportions of spirochetes and motile rods
in the test group (p = 0.01). Culturing showed that the test group harbored
significantly fewer pathogenic organisms at one month (p = 0.005). At two months,
the same sites harbored significantly more ''beneficial'' bacteria (p = 0.02).
Moreover, all sites of the test group initially harboring P. gingivalis (6/10)
became negative after treatment. These findings suggest that it is possible to
achieve a significant improvement of the treatment outcome (both microbiologically
and clinically) with a one-stage full-mouth disinfection.
AN - rayyan-563562386
AU - Quirynen, M.
AU - Dekeyser, C.
AU - Eyssen, H.
DO - 10.1177/00220345950740080501
IS - 8
PY - 1995
SN - ["0022-0345", "1544-0591"]
SP - 1459-1467
ST - FULL-VS PARTIAL-MOUTH DISINFECTION IN THE TREATMENT OF PERIODONTAL INFECTIONS
- SHORT-TERM CLINICAL AND MICROBIOLOGICAL OBSERVATIONS
TI - FULL-VS PARTIAL-MOUTH DISINFECTION IN THE TREATMENT OF PERIODONTAL INFECTIONS
- SHORT-TERM CLINICAL AND MICROBIOLOGICAL OBSERVATIONS
VL - 74
Y2 - 8
ID - 15760
ER -
TY - JOUR
AB - In a standard periodontal treatment strategy with consecutive root planings
(per quadrant at a one- to two-week interval), re-infection of a disinfected area
might occur before completion of the treatment. This study examines, both
clinically and microbiologically, whether a full-mouth disinfection within 24 hours
significantly improves the outcome of periodontal treatment. Ten patients with
advanced chronic periodontitis were randomly allocated to a test and a control
group. The patients from the control group received scalings and root planings as
well as oral hygiene instructions per quadrant at two-week intervals. Full-mouth
disinfection in the test group was sought by the removal of all plaque and calculus
(in two visits within 24 hours). In addition, at each of these visits, the tongue
was brushed with a 1% chlorhexidine gel for one min and the mouth rinsed with a
0.2% chlorhexidine solution for two min. Furthermore, subgingival chlorhexidine
(1%) irrigation was performed in all pockets. The recolonization of the pockets was
retarded by oral hygiene and 0.2% chlorhexidine rinses during two weeks. The
clinical parameters were recorded, and plaque samples were taken from the right
upper quadrant at baseline and after one and two months. The test group patients
showed a significantly higher reduction in probing depth for deep pockets at both
follow-up visits (p < 0.05). At the one-month visit, differential phase-contrast
microscopy revealed significantly lower proportions of spirochetes and motile rods
in the test group (p = 0.01). Culturing showed that the test group harbored
significantly fewer pathogenic organisms at one month (p = 0.005).(ABSTRACT
TRUNCATED AT 250 WORDS)
AN - rayyan-563561069
AU - Quirynen, M.
AU - Bollen, C. M.
AU - Vandekerckhove, B. N.
AU - Dekeyser, C.
AU - Eyssen, H.
IS - 8
KW - chlorhexidine
disinfectant agent
adult
article
bacterial infection
chronic disease
clinical trial
controlled study
female
follow up
gel
human
lavage
male
microbiology
middle aged
mouth hygiene
periodontitis
spirochete infection
tongue
tooth calculus
tooth plaque
LA - English
PY - 1995
SN - 0022-0345
SP - 1459-1467
ST - Full- vs. partial-mouth disinfection in the treatment of periodontal
infections: short-term clinical and microbiological observations
T2 - J. Dent. Res.
TI - Full- vs. partial-mouth disinfection in the treatment of periodontal
infections: short-term clinical and microbiological observations
VL - 74
ID - 14443
ER -
TY - JOUR
AB - OBJECTIVES: The aim of this study is to assess the clinical and
microbiological effects of a single subgingival administration of sodium
hypochlorite gel (NaOCl) and compare it with 1% chlorhexidine (CHX) gel and a
placebo gel following mechanical re-instrumentation during supportive periodontal
therapy (SPT). MATERIALS AND METHODS: Sixty-two patients who had been treated for
stage III-IV periodontitis and enrolled in SPT were included in the study based on
following criteria: (1) active periodontal therapy completed at least 6 months
before enrollment in the study, (2) presence of at least 4 non-adjacent sites with
probing pocket depths (PPDs) ≥ 4 mm with bleeding on probing (BOP), or presence of
5-8 mm PPDs with or without BOP. All sites presenting PPD ≥ 4 mm and BOP at
baseline and 3-, 6-, and 9-month follow-up timepoints were subgingivally re-
instrumented with ultrasounds. Selected patients were randomly assigned into three
groups and treated additionally with a single subgingival administration of NaOCl
gel (group A); 1% CHX gel (group B); and placebo gel (group C). Main outcome
variable was pocket closure at 12 months. Secondary outcome variables were changes
in mean PPD, BOP, and clinical attachment level (CAL) along with changes in the
numbers of the following five keystone bacterial pathogens: Aggregatibacter
actinomycetemcomitans (A.a.), Porphyromonas gingivalis (P.g.), Prevotella
intermedia (P.i.), Tannerella forsythia (T.f.), and Treponema denticola (T.d.).
RESULTS: At 12 months, pocket closure was obtained in 77.5% in the NaOCl treated
sites. The reduction in PPD was higher with CHX than with NaOCl, although a
statistically significant adjunctive effect for NaOCl (P = 0.028) was only observed
in comparison with placebo only. Mean CAL improved in all groups and at all
timepoints, compared to the baseline (P < 0.05). However, after 6 months, CAL gain
was statistically significantly higher in the NaOCl treated group than following
application of CHX (P = 0.0026). CONCLUSION: In SPT patients, a single adjunctive
use of a NaOCl gel may provide benefits in controlling inflammation and residual
pockets. TRIAL REGISTRATION: ISRCTN Registry of Clinical Trials (ISRCTN11387188).
CLINICAL RELEVANCE: A baseline single application of NaOCl gel in conjunction with
mechanical debridement may achieve substantial pocket closure in patients enrolled
in SPT; treatment time, cost, and applicability considerations should be taken into
account when selecting this therapy.
AN - rayyan-563559798
AU - Radulescu, V.
AU - Boariu, M. I.
AU - Rusu, D.
AU - Roman, A.
AU - Surlin, P.
AU - Voicu, A.
AU - Didilescu, A. C.
AU - Jentsch, H.
AU - Siciliano, V. I.
AU - Ramaglia, L.
AU - Vela, O.
AU - Kardaras, G.
AU - Sculean, A.
AU - Stratul, S. I.
DO - 10.1007/s00784-022-04618-3
IS - 11
KW - chlorhexidine
hypochlorite sodium
controlled study
dental scaling
human
microbiology
periodontal pocket
periodontitis
LA - English
PY - 2022
SN - 1436-3771
SP - 6639-6652
ST - Clinical and microbiological effects of a single application of sodium
hypochlorite gel during subgingival re-instrumentation: a triple-blind randomized
placebo-controlled clinical trial
TI - Clinical and microbiological effects of a single application of sodium
hypochlorite gel during subgingival re-instrumentation: a triple-blind randomized
placebo-controlled clinical trial
VL - 26
ID - 13172
ER -
TY - JOUR
AB - Background and Aim: Adjunctive topical antimicrobials exert an antimicrobial
effect in sites inaccessible to mechanical therapy and possibly suppress pathogens
and interrupt further periodontal disease progression (Eickholz et al., 2002;
Dannewitz et al., 2009; Tonetti et al 2012). Sodium hypochlorite (SH) is a valuable
alternative, for its broad antimicrobial activity, fast bactericidal action, and
for its non-toxicity (Jurczyk, 2016; Slots, 2002). To assess the clinical effects
of the adjunctive subgingival administration of a SH gel (Perisolv, Regedent,
Zurich, Switzerland) in comparison to a chlorhexidine and a placebo gel in
conjunction with ultrasonic subgingival instrumentation (USI) and air-polishing,
during the first year of supportive periodontal therapy (SPT) and to assess the
stability of the effect. Methods: In this triple-blind randomized placebo-
controlled clinical study, 62 SPT subjects with recurrent or persistent pockets
were randomly assigned to USI with (test) or without (control) administration of
Perisolv in four residual pockets with PD ≥4 mm and positive BOP. Intergroup
differences in PD, BOP reductions, CAL were evaluated at 3, 6, 9 and 12 months.
Primary outcome was “pocket closure” (transition to PD ≤4 mm without BOP). Results:
For “pocket closure” a significant adjunctive effect for Perisolv was observed at
12 months compared with placebo group (p < 0.05). Mean PPD (12 months) was reduced
by 0.81 ± 0.38 mm in the test group, by 0.61 ± 0.52 mm in Chlorhexidine group, and
by 0.75 ± 0.58 mm in placebo group, respectively, without reaching statistical
significance. BOP sites in Perisolv group were significantly reduced compared to
Chlorhexidine and placebo groups from baseline to 12 months (p < 0.05): 12.50%
versus 28.95% and 31.94%, respectively. Statistically significant CAL gain was
achieved in all three groups, compared to baseline (p < 0.005). No adverse events
were recorded. Conclusions: Subgingivally administered SH gel may provide longterm
benefits in controlling inflammation and deep pockets in SPT patients with a
satisfactory level of oral hygiene.
AN - rayyan-563559841
AU - Radulescu, V.
AU - Stratul, S. I.
AU - Rusu, D.
AU - Roman, A.
AU - Surlin, P.
AU - Calniceanu, H.
AU - Vela, O. C.
AU - Boldeanu, C.
AU - Belova, A.
AU - Boariu, M.
DO - 10.1111/jcpe.13636
KW - chlorhexidine
hypochlorite sodium
placebo
adult
clinical trial
conference abstract
controlled study
drug therapy
female
human
inflammation
male
mouth hygiene
outcome assessment
periodontitis
periodontium
ultrasound
LA - English
PY - 2022
SN - 1600-051X
SP - 179-180
ST - Clinical and microbiological effects of single application of a NaOCl gel in
maintenance patients treated for periodontitis stages III-IV. A triple-blind
randomized placebo-controlled clinical trial
TI - Clinical and microbiological effects of single application of a NaOCl gel in
maintenance patients treated for periodontitis stages III-IV. A triple-blind
randomized placebo-controlled clinical trial
VL - 49
ID - 13215
ER -
TY - JOUR
AB - The aim of this study was to evaluate the efficacy of 3 commercially
available periodontal systems for local delivery of antibiotics as adjuncts to
scaling and root planing in treatment of sites with persistent periodontal lesions
following a course of scaling and root planing. Fifty-four patients with 4 pockets
≤5 mm and bleeding on probing and/or suppuration were randomized in 4 treatment
groups including: scaling and root planing plus application of 25% tetracycline
fiber (S+Tet) (13 patients), scaling and root planing plus application of 2%
minocycline gel (S+Min) (14 patients), scaling and root planing plus application of
25% metronidazole gel (S+Met) (14 patients), and scaling and root planing alone (S)
(13 patients). Clinical measurements were taken at baseline and 6 weeks after the
end of treatment periods. All treatments were applied using the distributors'
recommended protocols and resulted in significant improvement in probing depth,
attachment level, bleeding on probing and the modified gingival index (MGI) scores.
The improvements in clinical parameters were greater in all three adjunctive
treatment groups than scaling and root planing alone. The mean probing depth
reductions were: S+Tet=1.35 mm, S+Met=0.95 mm, S+Min=0.87 mm and S=0.60 mm. The
probing depth reduction was significantly greater in the scaling plus tetracycline
fiber group than the scaling and root planing alone group (P=0.002). The difference
between groups in improvement of attachment level or bleeding on probing was not
significant. Scaling plus tetracycline fiber treatment resulted in the greatest
reduction in the MGI scores which was significantly greater than all other groups.
While the frequency of sites with suppuration was markedly reduced following all
treatments, it reached zero in the scaling plus tetracycline fiber group. No
serious adverse effects were observed or reported for any treatment. While all
three locally applied antimicrobial systems seem to offer some benefit over scaling
and root planing alone, a treatment regimen of scaling and root planing plus
tetracycline fiber replacement gave the greatest advantage in the treatment of
persistent periodontal lesions at least during the 6-week period following
treatment.
AN - rayyan-563561058
AU - Radvar, M.
AU - Pourtaghi, N.
AU - Kinane, D. F.
DO - 10.1902/jop.1996.67.9.860
IS - 9
metronidazole
minocycline
tetracycline
article
clinical trial
controlled study
human
periodontal disease
periodontitis
LA - English
PY - 1996
SN - 0022-3492
SP - 860-865
ST - Comparison of 3 periodontal local antibiotic therapies in persistent
periodontal pockets
TI - Comparison of 3 periodontal local antibiotic therapies in persistent
periodontal pockets
VL - 67
ID - 14432
ER -
TY - JOUR
AB - Incorporation of an emulsion onto a gel base develops a drug delivery system
with improved characteristics, known as emulgel, that can envelop both hydrophilic
and lipophilic molecules, and therefore increase stability and penetration of
topical formulations. Such a drug delivery system provides controlled drug release
that has more patient compliance and higher therapeutic efficacy. Emulgel is
prepared in three main stages, preparation of water-in-oil or oil-in-water
emulsion, providing the gel base, and incorporation of prepared emulsion onto gel
base with continuous stirring. Various materials such as different oils (e.g.
sesame oil, balsam oil, and mineral oil), emulsifiers (e.g. Tween® and Span® as the
non-ionic surfactant, polyvinyl alcohol), and gelling agents including cellulose
derivatives such as hydroxypropyl methylcellulose (HPMC), hydroxyethylcellulose
(HEC) and carboxymethyl cellulose (CMC) in different concentrations are used in
emulgel preparation. The physical properties, particle size distribution,
spreadability, permeation, and drug release rate are evaluated in their development
and characterization. They are used in skin disorders and other diseases such as
chronic anal fisher. Also, anti-acne, analgesic, and anti-inflammatory drugs have
been formulated as emulgel delivery system and their effects have been studied. In
this article, the subject is to review the characteristics, preparation methods,
and therapeutic efficacy as well as the potential clinical use of emulgels.
AN - rayyan-563559701
AU - Raeisi Estabragh, M. A.
AU - Sajadi Bami, M.
AU - Dehghannoudeh, G.
AU - Noudeh, Y. D.
AU - Moghimipour, E.
DO - 10.1016/j.ijbiomac.2023.124538
KW - analgesic agent
anti acne agent
balsam oil
capsaicin
dexibuprofen
emulgel
emulsifying agent
gel
gelling agent
metronidazole
mineral oil
natural gum
nicotinamide
nonionic surfactant
oil
polyvinyl alcohol
resveratrol
sesame seed oil
unclassified drug
water oil cream
anus disease
chronic disease
dispersity
drug dosage form
drug efficacy
drug formulation
drug penetration
drug release
drug solubility
drug stability
emulsion
gingivitis
human
hydrophilicity
inflammation
lipophilicity
nanopharmaceutics
nonhuman
particle size
patient compliance
pharmacological procedures
physical chemistry
physical parameters
review
rosacea
skin disease
skin irritation
synthesis
viscosity
LA - English
PY - 2023
SN - ["1879-0003", "0141-8130"]
ST - Cellulose derivatives and natural gums as gelling agents for preparation of
emulgel-based dosage forms: A brief review
TI - Cellulose derivatives and natural gums as gelling agents for preparation of
emulgel-based dosage forms: A brief review
VL - 241
ID - 13075
ER -
TY - JOUR
AB - The pervasiveness of oral bacterial infections in diabetic patients is a
serious health concern that may produce severe complications. We investigated 26
Ayurvedic medicinal plants traditionally used for treatment of the oral bacterial
infections with the aim to look for new promising drug leads that can be further
employed for herbal formulation design. The plants were grouped into three
categories based on traditional usage. All plant extracts were examined for
antibacterial, antibiofilm and antiquorum-sensing properties. The plants with
significant activities including Juglans regia, Syzygium aromaticum, Eruca sativa,
Myristica fragrans, Punica granatum and Azadirachta indica were further analyzed
using HPLC-DAD-QToF and GC-MS. In silico and in vitro activity was evaluated for
selected constituents. Finally, it could be concluded that eugenol and 2-
phenylethylisothiocyanate are major contributors towards inhibition of bacterial
biofilms and quorum sensing.
AN - rayyan-563559933
AU - Rafey, A.
AU - Amin, A.
AU - Kamran, M.
AU - Haroon, U.
AU - Farooq, K.
AU - Foubert, K.
AU - Pieters, L.
IS - 12
KW - Agilent 1200
amoxicillin
antibiotic agent
apigenin
ayurvedic drug
azithromycin
caryophyllene
ceftazidime
ceftriaxone
ciprofloxacin
Eruca sativa extract
eugenol
gallic acid
gentamicin
humulene
imipenem
Juglans regia extract
juglone
meropenem
metronidazole
Myristica fragrans extract
ofloxacin
phenethyl isothiocyanate
plant extract
pomegranate extract
quercetin
quercitrin
Syzygium aromaticum extract
tetracycline
unclassified drug
article
Azadirachta indica
bacterial growth
bacterial strain
Chromobacterium violaceum
clove
computer model
controlled study
diabetes mellitus
drug determination
Eruca vesicaria subsp. sativa
flame ionization detection
gene sequence
hydrodistillation
in vitro study
Juglans regia
medicinal plant
molecular docking
mouth hygiene
nonhuman
nutmeg
periodontitis
phytochemistry
pomegranate
quorum quenching
tooth plaque
X ray crystallography
zone of inhibition
LA - English
PY - 2021
SN - 2079-6382
ST - Analysis of plant origin antibiotics against oral bacterial infections using
in vitro and in silico techniques and characterization of active constituents
T2 - Antibiotics
TI - Analysis of plant origin antibiotics against oral bacterial infections using
in vitro and in silico techniques and characterization of active constituents
VL - 10
ID - 13307
ER -
TY - JOUR
AB - AIM: The aim of the present study is to evaluate the efficacy of curcumin gel
as local drug delivery post-scaling and root planing and its effect on clinical
parameters like plaque, gingival scores, pocket depth, and clinical attachment
level (CAL). MATERIALS AND METHODS: Ten patients with two sites in the
contralateral quadrants having probing pocket depths (PPDs) of ≥5 mm were selected.
Full-mouth scaling and root planing (SRP) was performed followed by the application
of curcumin gel on a single side. Assessment of plaque index (PI), gingival index
(GI), PPD, and CALs were done at the baseline and at the 4th week. RESULTS: The
results revealed that there was a statistically significant reduction in PI and
probing depth in the test group when compared with the control group. CAL was
improved but the results were not statically significant. CONCLUSION: The local
application of curcumin gel when used in conjunction with SRP showed a significant
improvement in periodontal parameters and has a beneficial effect in patients with
chronic periodontitis. CLINICAL SIGNIFICANCE: Curcumin gel as an adjunct to SRP
showed a marked improvement in restoring gingival health by an improvement in
clinical parameters. It has proven properties like anti-inflammatory, antioxidant,
antimicrobial, hepatoprotective, immunostimulant, antiseptic, antimutagenic, and it
also accelerates wound healing. It may be a more acceptable and viable option for
the common man. Curcumin can be used as an effective alternative local drug
delivery agent.
AN - rayyan-563560186
AU - Raghava, K. V.
AU - Sistla, K. P.
AU - Narayan, S. J.
AU - Yadalam, U.
AU - Bose, A.
AU - Mitra, K.
DO - 10.5005/jp-journals-10024-2608
IS - 7
KW - curcumin
controlled study
dental scaling
human
male
root planing
treatment outcome
LA - English
PY - 2019
SN - 1526-3711
SP - 842-846
ST - Efficacy of Curcumin as an Adjunct to Scaling and Root Planing in Chronic
Periodontitis Patients: A Randomized Controlled Clinical Trial
TI - Efficacy of Curcumin as an Adjunct to Scaling and Root Planing in Chronic
Periodontitis Patients: A Randomized Controlled Clinical Trial
VL - 20
ID - 13560
ER -
TY - JOUR
AB - For the effective treatment of periodontitis, ciprofloxacin hydrochloride
(HCl) medicated dental gels are prepared with different hydrophilic polymers (MC,
HPMC, HPC, and HEC) in different concentrations of propylene glycol. The
formulations are subjected to various physicochemical studies like pH,
spreadability, extrudability, viscosity, drug content, in vitro drug release, and
rheological and stability studies. During the rheological studies plots of shear
rate versus viscosity showed that all the gels were non-Newtonian and exhibited
pseudoplastic behavior. in vitro drug release studies were carried out in the
diffusion cell using a pH 7.2 phosphate buffer as a receptor medium. Formulations
exhibited an extended release of the drug for over a period of 6 hours and the
release depended on the type of polymer and concentrations of propylene glycol
used. Stability studies showed no significant variations ( P > 0.05) in pH,
spreadability, viscosity, extrudability, and drug content. An in vitro release
study concluded that hydrocolloid based ciprofloxacin hydrochloride medicated
dental gels appear to be probably extend the release of ciprofloxacin
hydrochloride. Optimal formulations were selected for in vivo or clinical studies.
The clinical evaluation of ciprofloxacin hydrochloride gels was carried out to
determine the efficacy in the treatment of periodontitis. Six groups, each
containing five patients, were used in the study. All the patients were evaluated
for plaque index (PI) and gingival index (GI), probing depth (PD), and bleeding on
probing (BOP). In all these studies, two groups were treated with formulations
alone and another two groups were treated with formulations along with scaling and
root planning. One group was treated with scaling and root planning only, whereas,
the last group was treated as control (No treatment). All the groups showed a
similar baseline PI. However, the PI values decreased remarkably in the groups
treated with formulation along with scaling and root planning when compared to the
other groups. Similarly, the results of GI, BOP, and PD also showed a significant
reduction ( P < 0.05) in the groups treated with formulation along with scaling and
root planning compared to other groups. The above studies revealed that the
adjunctive use of ciprofloxacin hydrochloride gels along with scaling and root
planning results in significant benefits, in the treatment of periodontitis.
AN - rayyan-563560681
AU - Raghavendra Rao, N. G.
AU - Rao, K. P.
AU - Muthalik, S.
AU - Shivanand, A.
DO - 10.4103/0973-8398.55050
IS - 2
KW - aspartame
ciprofloxacin
glycerol
methyl paraben
methylcellulose
propyl paraben
propylene glycol
article
controlled study
drug efficacy
drug formulation
drug release
flow kinetics
gel
gingiva
human
hydrocolloid
hydrophilicity
oral bleeding
periodontitis
pH
physical chemistry
shear rate
tooth plaque
tooth root
viscosity
LA - English
PY - 2009
SN - ["0973-8398", "1998-409X"]
SP - 125-134
ST - Clinical studies and antimicrobial activity of ciprofloxacin hydrochloride
medicated dental gels for periodontal infection
TI - Clinical studies and antimicrobial activity of ciprofloxacin hydrochloride
medicated dental gels for periodontal infection
VL - 3
ID - 14055
ER -
TY - JOUR
AB - Analyze the potency of proanthocyanidins extract of cacao peel extract to
inhibit TNF-α and COX-2 expression in rat gingival sulcus fluid induced by
Porphyromonas gingivalis. 3 groups in this study, namely negative control, positive
control, and treatment. In all groups, on the 0th day, gingival sulcus fluid was
taken, then the rats were induced by Porphyromonas gingivalis once every 3 days for
2 weeks; then in the negative control group a placebo gel was applied and the
treatment group was applied proanthocyanidin gel of cacao peel extract every day
for 7, 14, and 28 days and serial gingival crevicular fluid collection was carried
out on days 7, 14, and 28. The expression of TNF-α and COX-2 in the gingival
crevicular fluid was observed using the ELISA method. The statistical test used was
Anova. There were a significant difference in TNF-α and COX-2 expressions (p
<0.05). There was a decrease in the expression of COX-2 in rat gingival sulcus
fluid induced by Porphyromonas gingivalis and given 10% cacao peel extract.
Proanthocyanidin in the cacao peel extract has the potential to reduce TNF-α and
COX-2 expression in periodontitis rats.
AN - rayyan-563560089
AU - Rahayu, Y. C.
AU - Dharmayanti, A. W. S.
AU - Putri, Y. E.
AU - Irmawati, A.
DO - 10.31838/IJPR/2020.12.04.594
IS - 4
KW - acetic acid
acetone
antiinfective agent
antioxidant
cyclooxygenase 2
gingipain cysteine endopeptidase
interleukin 1
interleukin 1beta
interleukin 6
interleukin 8
lipopolysaccharide
metronidazole
plant extract
proanthocyanidin
prostaglandin E2
RANTES
thromboxane A2
animal experiment
animal model
article
bacterium culture
Bacteroidetes
cacao
controlled study
drug isolation
fimbria
gingivitis
ion monitoring
nonhuman
periodontitis
protein expression
rat
spectrophotometry
LA - English
PY - 2020
SN - 0975-2366
SP - 4337-4343
ST - The analysis of proanthocyanidins cacao peel extract (Theobroma cacao L.)
potential on the expression of TNF-α and COX-2 on periodontitis rat
TI - The analysis of proanthocyanidins cacao peel extract (Theobroma cacao L.)
potential on the expression of TNF-α and COX-2 on periodontitis rat
VL - 12
ID - 13463
ER -
TY - JOUR
AN - rayyan-563561520
AU - Rahayu, Y. C.
AU - Setiawatie, E. M.
AU - Rahayu, R. P.
AU - Sakinah, N. N.
AU - Kusumawardani, B.
AU - Gunadi, A.
AU - Ryandhana, P. H.
DO - 10.48048/tis.2023.6535
IS - 6
PY - 2023
ST - Effects of Cocoa Pod Husk Extract (Theobroma Cacao L.) on Alveolar Bone in
Experimental Periodontitis Rats
T2 - Trends in Sciences
TI - Effects of Cocoa Pod Husk Extract (Theobroma Cacao L.) on Alveolar Bone in
Experimental Periodontitis Rats
85152654481&doi=10.48048%2ftis.2023.6535&partnerID=40&md5=42b7abdeafb0b137208f141fa
4344a14
VL - 20
ID - 14894
ER -
TY - JOUR
AB - This study aims to develop a thermosensitive mucoadhesive periodontal in situ
gel of secnidazole for local release of drug for treatment of periodontitis, in
order to increase the drug residence time and to increase patient compliance while
lowering the side effects of the drug. Cold method was used to prepare 30 formulas
of secnidazole periodontal in situ gel, using different concentrations of
thermosensitive polymers (poloxamer407 alone or in combination with poloxamer 188)
and methyl cellulose (MC) or hydroxypropyl methylcellulose (HPMC K4M)in different
concentrations used as mucoadhesive polymer and the resultant formulations were
subjected to several tests such as gelation temperature GT, appearance and pH
value. The formulas with the most appropriate GT were subjected to in-vitro drug
release. Three formulas were chosen with appropriate release, F6 (15% P407, 1% MC),
F29 (18%P407,3% P188, 0.8% HPMC) and F30 (18%P407,3% P188, 1% HPMC). These formulas
were subjected to mucoadhesive force, viscosity, drug content, spreadability,
gelation time and Fourier Transform Infrared (FTIR) compatibility studies. The
results indicates that formula F29 and F30 have best gelation temperatures (33°C,
32°C) gel strength (1.5h,2h) mucoadhesive force of (17.1, 23.4 dyne/cm2 ) and in-
vitro drug release (98.2%, 100%) respectively during 3.5h and gelation, time about
10 seconds for both formulas and FTIR spectrum study show absence of important
interaction between secnidazole and the polymers used.
AN - rayyan-563559925
AU - Raheema, D. A.
AU - Kassab, H. J.
DO - 10.31351/vol31iss2pp50-61
IS - 2
KW - gel
methylcellulose
poloxamer
polymer
secnidazole
article
cold stress
controlled study
drug formulation
drug release
drug screening
drug synthesis
gelation
heat sensitivity
human
periodontitis
pH measurement
phase separation
retention time
temperature
viscosity
LA - English
PY - 2022
SN - ["2521-3512", "1683-3597"]
SP - 50-61
ST - Preparation and in-vitro Evaluation of Secnidazole as Periodontal In-situ Gel
for Treatment of Periodontal Disease
T2 - Iraqi J. Pharm. Sci.
TI - Preparation and in-vitro Evaluation of Secnidazole as Periodontal In-situ Gel
for Treatment of Periodontal Disease
VL - 31
ID - 13299
ER -
TY - JOUR
AB - Background: To evaluate and compare the efficacy of antimicrobial
Photodynamic therapy (aPDT), Local Drug Delivery (LDD) of 1.2 % Simvastatin gel as
an adjunct to scaling and root planning (SRP) and SRP alone in the treatment of
Periodontitis using clinical, microbiological and biochemical parameters. Materials
and methods: A total of 33 test sites in 11 Grade A Stage II periodontitis patients
were randomly divided into three groups: GROUP I: Treated by SRP alone (SRP group);
GROUP II: Treated by SRP followed by aPDT (aPDT group); GROUP III: Treated by SRP
followed by single subgingival application of 1.2 % simvastatin gel (SMV group).
Clinical parameters including API, PBI, PPD and RAL were assessed. Quantification
of Porphyromonas gingivalis was evaluated by RT-PCR technique and estimation of
RANKL levels was checked by ELISA. All assessments were done at baseline and 3
months Results: All three groups showed significant reduction in the scores of
clinical parameters, P. gingivalis DNA copy numbers and GCF RANKL levels at 3
months post therapy compared to baseline (p < 0.05). On comparison between the
three groups, the results were non significant for all parameters both at baseline
and at 3 months post therapy (p > 0.05). However slightly greater reduction was
seen in the mean scores of PPD and RAL in the SMV Group and in P. gingivalis DNA
copy numbers and GCF RANKL levels in aPDT group compared to the other groups
although statistically non significant. A significant positive correlation(p <
0.05) was observed between P. gingivalis DNA copy numbers and PPD scores in SMV
group and a significant negative correlation(p < 0.05) was observed between P.
gingivalis DNA copy numbers and API & PBI scores in SRP group at 3 months follow
up. Conclusions: aPDT, 1.2 % SMV local drug delivery as adjunct to SRP and SRP
alone are effective in improving clinical parameters, reducing P. gingivalis DNA
copy numbers and GCF RANKL levels. The superiority of one over another modality of
treatment could not be established in this short term study.
AN - rayyan-563562372
AU - Rahman, S.
AU - Gayathri, G. V.
AU - Mehta, D. S.
DO - 10.1016/j.pdpdt.2020.102017
PY - 2020
SN - ["1572-1000", "1873-1597"]
ST - A clinico-microbiological and biochemical study evaluating the adjunctive use
of antimicrobial photodynamic therapy and local drug delivery of 1.2 % simvastatin
gel compared to scaling and root planing alone
TI - A clinico-microbiological and biochemical study evaluating the adjunctive use
VL - 32
Y2 - 12
ID - 15746
ER -
TY - JOUR
AB - Background: To evaluate and compare the efficacy of antimicrobial
Photodynamic therapy (aPDT), Local Drug Delivery (LDD) of 1.2 % Simvastatin gel as
an adjunct to scaling and root planning (SRP) and SRP alone in the treatment of
Periodontitis using clinical, microbiological and biochemical parameters. Materials
and methods: A total of 33 test sites in 11 Grade A Stage II periodontitis patients
were randomly divided into three groups: GROUP I: Treated by SRP alone (SRP group);
GROUP II: Treated by SRP followed by aPDT (aPDT group); GROUP III: Treated by SRP
followed by single subgingival application of 1.2 % simvastatin gel (SMV group).
Clinical parameters including API, PBI, PPD and RAL were assessed. Quantification
of Porphyromonas gingivalis was evaluated by RT –PCR technique and estimation of
RANKL levels was checked by ELISA. All assessments were done at baseline and 3
months Results: All three groups showed significant reduction in the scores of
clinical parameters, P. gingivalis DNA copy numbers and GCF RANKL levels at 3
months post therapy compared to baseline (p < 0.05). On comparison between the
three groups, the results were non significant for all parameters both at baseline
and at 3 months post therapy (p > 0.05). However slightly greater reduction was
seen in the mean scores of PPD and RAL in the SMV Group and in P. gingivalis DNA
copy numbers and GCF RANKL levels in aPDT group compared to the other groups
although statistically non significant. A significant positive correlation(p <
0.05) was observed between P. gingivalis DNA copy numbers and PPD scores in SMV
group and a significant negative correlation(p < 0.05) was observed between P.
gingivalis DNA copy numbers and API & PBI scores in SRP group at 3 months follow
up. Conclusions: aPDT, 1.2 % SMV local drug delivery as adjunct to SRP and SRP
alone are effective in improving clinical parameters, reducing P. gingivalis DNA
copy numbers and GCF RANKL levels. The superiority of one over another modality of
treatment could not be established in this short term study.
AN - rayyan-563560071
AU - Rahman, S.
AU - Gv, G.
AU - Mehta, D. S.
DO - 10.1016/j.pdpdt.2020.102017
KW - dental laser
antiinfective agent
aurogreen
bacterial DNA
gel
indocyanine green
simvastatin
adult
approximal plaque index
article
clinical article
controlled study
dental scaling
female
follow up
gene dosage
human
intragingival drug administration
local therapy
male
periodontitis
plaque index
priority journal
prospective study
relative attachment level
root planing
single drug dose
LA - English
PY - 2020
SN - ["1873-1597", "1572-1000"]
ST - A clinico-microbiological and biochemical study evaluating the adjunctive use
TI - A clinico-microbiological and biochemical study evaluating the adjunctive use
VL - 32
ID - 13445
ER -
TY - JOUR
AB - Antimicrobial therapies for oral diseases have been in use for centuries, but
have undergone rapid changes in the last decade. In the coming years, antimicrobial
strategies will become more sophisticated and efficacy will be greatly improved as
new therapeutic technologies emerge. New delivery systems for common antimicrobials
and novel agents to modulate the immune system, as well as biofilm formation and
maturation, may be on the horizon. This review describes the development and the
application of intraoral antimicrobial drug delivery in the oral environment.
Current clinical uses of antimicrobials as well as future approaches to the
treatment and prevention of oral infectious diseases are discussed. © 2005 Prous
Science. All rights reserved.
AN - rayyan-563560839
AU - Raj, P. A.
AU - Dentino, A. R.
DO - 10.1358/dnp.2005.18.6.927928
IS - 6
KW - adhesive agent
alginic acid
amoxicillin
amphotericin B
amphotericin B deoxycholate
antibiotic agent
antiinfective agent
minocycline
doxycycline hyclate
chitosan
chlorhexidine
ciprofloxacin
clindamycin
clotrimazole
copolymer
defensin
doxycycline
fluconazole
fluoride
heparin
histatin
hydroxyapatite
listerine
metronidazole
nystatin
saliva protein
tetracycline
total
triclosan
unindexed drug
vasculotropin
zinc
biofilm
gingivitis
human
hydrogel
immune system
immunomodulation
mouth disease
mouth infection
nonhuman
periodontitis
review
stomatitis
tooth plaque
achromycin
actisite
amoxil
arestin
atridox
augmentin
cipro
cleocin
diflucan
doryx
flagyl
fungizone
minocin
mycelex
mycostatin
periochip
periogard
LA - English
PY - 2005
SN - 0214-0934
SP - 362-374
ST - Intraoral delivery of antimicrobials
T2 - Drug News Perspect.
TI - Intraoral delivery of antimicrobials
VL - 18
ID - 14213
ER -
TY - JOUR
AB - Objective: To determine the effect of a semi-synthetic-glycosaminoglycan
Ether (SAGE) as a universal therapeutic benefit to reduce periodontal inflammation
and alveolar bone loss in naturally occurring-beagle-dog model of periodontal
disease as a surrogate for human non-risk associated natural periodontitis.
Methods: Six adult female dogs with generalized periodontitis were distributed into
two groups: control and SAGE treatment (n=3/group). After a 1-hour full-mouth
scaling and root planning (SRP) at baseline, control or SAGE treatment (50mg/mL)
bioadhesive gel formulation was locally applied for 12 weeks. Various clinical
periodontal measurements (probing depth, CAL) were measured at different time
periods (baseline, 4, 8 and 12 weeks), and gingival crevicular fluid (GCF), blood
samples and gingival tissue biopsies (12 week) were analyzed for inflammatory
mediators, collagenases and cell-signaling molecules. Standardized radiographs were
taken at baseline and 12week period. Results: SAGE treatment significantly reduced
gingival inflammation (GCF flow), pocket depth (PD), and clinical attachment loss
(CAL) compared to control. SAGE also considerably reduced alveolar bone loss and
reduced MMP-9, IL-6, CRP levels in gingival tissue, GCF and plasma. Cell-signaling
molecules in the inflammatory cascade system TLR-2, TLR-4, p38 MAPK, ERK1/2 and NF-
kB responded to SAGE in a pattern consistent with reductions at the active phase of
the inflammatory process and collagenolysis. Conclusion: In the beagle dog model of
periodontitis, local SAGE administration significantly attenuated clinical measures
of periodontitis, pro-inflammatory cytokines, MMPs, and signal transduction
molecules. All our studies, using in vitro and in vivo models, support the
therapeutic potential of SAGE as an innovative adjunct to SRP in the treatment of
chronic periodontal disease.
AN - rayyan-563559912
AU - Raja, V.
AU - Gu, Y.
AU - Lee, H. M.
AU - Deng, J.
AU - Prestwich, G.
AU - Ryan, M.
DO - 10.2147/JEP.S353757
C reactive protein
collagenase
gelatinase B
gm 1111
interleukin 6
semi synthetic glycosaminoglycan ether
unclassified drug
adult
alveolar bone loss
animal experiment
animal model
animal tissue
article
biopsy technique
blood sampling
controlled study
disease association
dog breed
drug effect
female
gingival tissue
gingivitis
human
in vitro study
in vivo study
inflammation
jaw radiography
nonhuman
periodontal disease
periodontitis
pilot study
risk factor
signal transduction
treatment duration
treatment outcome
treatment response
Western blotting
zymography
LA - English
PY - 2022
SN - 1179-1454
SP - 117-129
ST - SAGE: Novel Therapy to Reduce Inflammation in a Naturally Occurring-Dog Model
of Periodontal Disease
T2 - J. Exp. Pharmacol
TI - SAGE: Novel Therapy to Reduce Inflammation in a Naturally Occurring-Dog Model
of Periodontal Disease
VL - 14
ID - 13286
ER -
TY - JOUR
AB - Periodontal diseases are the conditions that affect the supporting structure
of teeth leading to the formation of pocket due to which tooth loss occurs, for
which site specific injectable drug delivery systems are gaining importance. In the
present study six batches of Ornidazole gels were prepared using natural
biodegradable polymers. Chitosan, Xanthum gum and Locust bean gum were taken in
variable concentrations. The formulated gels were characterized for surface pH,
viscosity, syringeability, bioadhesion strength, in vitro drug release studies and
antimicrobial susceptibility test. The results revealed that the surface pH was
within the range of neutral pH. The bioadhesion strength was maximum for F3
formulation (3% chitosan); viscosity values were ranging from 1400 to 1975
dyne/cm2. Best formulation in terms of cumulative percent drug release along with
bioadhesion was formulation F3 with 79.23% drug release for 7 days and fulfilled
many requirements of once a week delivery system, easy to fabricate, cost
effective, patient compliance is also very high. Zone of inhibition was also
satisfactory for all the formulations.
AN - rayyan-563560687
AU - Rajashree, M. S.
AU - Shukla, V.
AU - Vashudha, M.
AU - Bolmal, U. B.
AU - Manvi, F. V.
IS - 6
KW - algaroba
chitosan
lactic acid
ornidazole
polymer
xanthan
article
drug formulation
drug release
gel
nonhuman
patient compliance
periodontitis
pH
viscosity
LA - English
PY - 2009
SN - 0019-462X
SP - 25-31
ST - Development and characterization of ornidazole gels using natural polymers
for local treatment of periodontitis
T2 - Indian Drugs
TI - Development and characterization of ornidazole gels using natural polymers
for local treatment of periodontitis
VL - 46
ID - 14061
ER -
TY - CHAP
AN - rayyan-563561751
AU - Rajendran, A. K.
AU - Jayakumar, R.
DO - 10.1007/12_2021_92
PY - 2021
SP - 163-189
ST - Chitosan Based Biomaterials for Periodontal Therapy
T2 - Advances in Polymer Science
TI - Chitosan Based Biomaterials for Periodontal Therapy
85114299311&doi=10.1007%2f12_2021_92&partnerID=40&md5=4e70137ca4119d81189018562863a
ff5
VL - 288
ID - 15125
ER -
TY - JOUR
AN - rayyan-563561736
AU - Rajeshwaran, N.
AU - Ramamurthy, J.
AU - Rajeshkumar, S.
IS - 33
PY - 2020
SP - 32-42
ST - Green synthesis of grape seed oil mediated silver nanoparticle and
preparation of gel-for periodontal diseases
T2 - Plant Cell Biotechnology and Molecular Biology
TI - Green synthesis of grape seed oil mediated silver nanoparticle and
preparation of gel-for periodontal diseases
85092893541&partnerID=40&md5=a298d04c3d7a669b5e46639b217380c7
VL - 21
ID - 15110
ER -
TY - JOUR
AN - rayyan-563561842
AU - Dhamecha, D.
AU - Jagwani, S.
AU - Patil, D.
AU - Hegde, S.
AU - Potdar, R.
AU - Metgud, R.
AU - Jalalpure, S.
AU - Roy, S.
AU - Jadhav, K.
AU - Tiwari, N. K.
AU - Koduru, S.
AU - Hugar, S.
AU - Dodamani, S.
DO - 10.1016/j.msec.2017.03.054
PY - 2017
SP - 1506-1514
T2 - Materials Science and Engineering C
85015398467&doi=10.1016%2fj.msec.2017.03.054&partnerID=40&md5=d9899abdc765d8594dcf0
5fd4bedf614
VL - 75
ID - 15216
ER -
TY - JOUR
AB - Periodontitis (PD) is a microbial disease of tooth supporting tissues that
results in progressive destruction of surrounding soft and hard tissues with
eventual tooth mobility and exfoliation. Perioceutics, which includes the delivery
of therapeutic agents via systemic and local means as an adjunct to mechanical
therapy has revolutionized the arena of periodontal therapy. Selection of a right
antimicrobial agent with appropriate route of drug administration is the key to
successful periodontal therapy. Irrigating systems, fibers, gels, strips, films,
microparticles, nanoparticles and low dose antimicrobial agents are some of the
local drug delivery systems (LDDS) available in the field, which aims to deliver
antimicrobial agents to sub-gingival diseased sites with minimal or no side-effects
on other body sites. The present review aim to summarize the current state-of-the-
art technology on LDDS in periodontal therapy ensuring the the practitioners are
able to choose LDD agents which are custom made for a specific clinical condition.
AN - rayyan-563562187
AU - Dhamecha, D.
AU - Jagwani, S.
AU - Rao, M.
AU - Jadhav, K.
AU - Shaikh, S.
AU - Puzhankara, L.
AU - Jalalpure, S.
DO - 10.1016/j.jconrel.2019.06.038
PY - 2019
SN - ["0168-3659", "1873-4995"]
SP - 393-409
ST - Local drug delivery systems in the management of periodontitis: A scientific
review
T2 - JOURNAL OF CONTROLLED RELEASE
TI - Local drug delivery systems in the management of periodontitis: A scientific
review
VL - 307
Y2 - 8 y3 - 10
ID - 15561
ER -
TY - JOUR
AN - rayyan-563561776
AU - Rajini Kanth, M.
AU - Ravi Prakash, A.
AU - Sreenath, G.
AU - Reddy, V. S.
AU - Huldah, S.
DO - 10.7860/JCDR/2016/19772.9025
IS - 12
PY - 2016
SP - ZM01-ZM03
ST - Efficacy of specific plant products on dental caries causing microorganisms
T2 - Journal of Clinical and Diagnostic Research
TI - Efficacy of specific plant products on dental caries causing microorganisms
85000461302&doi=10.7860%2fJCDR
%2f2016%2f19772.9025&partnerID=40&md5=d249be2ecda5e3ae1e8b1378ca1a85a0
VL - 10
ID - 15150
ER -
TY - JOUR
AB - Purpose: Local drug delivery systems (LLD) are preferred over systemic
antibiotic therapy in indicated cases to avoid unnecessary large doses of drug,
development of antibiotic resistance etc. The search for the more suitable novel
vehicle for the local drug delivery that can render controlled release of drug at
periodontally infected sites are widely researched. i-PRF being autologous and
injectable could be a suitable vehicle for local delivery of drugs. This study aims
to evaluate the possibility of using i-PRF as a controlled release drug vehicle in
periodontal therapy. Methods: i-PRF obtained from centrifugation of 10 ml of blood
collected from volunteers are mixed with known concentration of doxycycline drug
and allowed to become a gel. The drug loaded gel is dispensed in artificial saliva
and allowed to degrade. At specific time intervals (1 hr, 3 hr, 5 hr, 7 hr, 3d, 5d,
7d, 9d, 14d) aliquot of the 200 microliter were collected from each sample and
subjected for spectrophotometric analysis. Results: The spectrophotometric results
show that the drug was detected in all the samples obtained from the 1 hr to the
14th day. Final concentration in the eluted samples seem to be gradually reducing
from the 1 hr to the 7 th hour and a steep downward pattern in the concentration
was absorbed from the 3 rd day until 14th day. Conclusions: The controlled drug
release profile of the i-PRF shows its a potential and suitable vehicle for LDD
system in periodontal therapy. Additionally, properties like the syringeability,
in-situ gel formation, and autologous fibrin nature may facilitate its direct
delivery into the periodontal pocket, getting moulded to the pocket shape with
attachment to the soft and hard tissue thereby ensuring the retention of the drug
loaded i-PRF in the confined pocket environment.
AN - rayyan-563559776
AU - Ram, A. J.
AU - Murugan, T.
AU - Ganapathy, D.
DO - 10.47750/jptcp.2023.30.12.023
IS - 12
KW - Jasco V-730
ciprofloxacin
doxycycline
drug vehicle
adult
article
controlled study
human
human experiment
in vitro study
periodontal therapy
periodontium
LA - English
PY - 2023
SN - ["2561-8741", "1710-6222"]
SP - e201-e209
ST - Use of injectable platelet rich fibrin (IPRF) as LDD vehicle containing
doxycycline in periodontal Therapy – In vitro study
TI - Use of injectable platelet rich fibrin (IPRF) as LDD vehicle containing
doxycycline in periodontal Therapy – In vitro study
VL - 30
ID - 13150
ER -
TY - JOUR
AB - Metronidazole (Mz) (an anaerobic antibacterial agent) was incorporated into
different bioadhesive matrices including gels and films using carbopol 934p (4%),
chitosan (3%) and hydroxypropyl methyl cellulose (HPMC) (3%). Penetration enhancers
including menthol (1%) or oleic acid (OA) (5%, 10%) were incorporated in such
formulations. The bioadhesive forces of the prepared matrices were determined and
expressed as detachment stresses (Dyne/cm(2)). Permeability of Mz across ear rabbit
skin and enhancement ratios (ER) were studied. The effects of selected Mz
formulations on the healing rate of experimentally induced periodontitis in guinea
pigs were estimated and histologically compared between treated and control groups.
The obtained results showed that the gel formulations containing carbopol 934p
exhibited maximum bioadhesive force with detachment stress equals to 66.98x10(2)
dyne/cm(2) followed by those containing chitosan (42.45x10(2) dyne/cm(2)) and HPMC
(26.41x10(2) dyne/cm(2)). There was a statistically significant difference (P<0.05)
between the detachment stresses of gel formulations containing penetration
enhancers and the corresponding ones without penetration enhancer. HPMC based films
had bioadhesive force (19.33, 16 and 13.67x10(2) dyne/cm(2)) higher than those
based on chitosan (5.33 and 7.33x10(2) dyne/cm(2)). Also, it was noticed that the
chitosan gel containing 1% menthol had the highest ER (5.13) among other gel
formulations. On the other hand, chitosan based film containing 5% OA has the
highest ER (1.73) among films. The effects of the selected formulations on the
healing periodontal wound showed that bioadhesive chitosan gel containing menthol
had accelerated the periodontal wound healing more than chitosan based film
containing oleic acid.
AN - rayyan-563562381
AU - Ramadan, E.
AU - Borg, T.
AU - El Hawary, Y. M.
AU - Saleh, N. M.
PY - 2010
SN - 1110-0052
SP - 79-94
ST - FORMULATION AND EVALUATION OF METRONIDAZOLE BIOADHESIVE MATRICES FOR
TREATMENT OF PERIODONTITIS
T2 - BULLETIN OF PHARMACEUTICAL SCIENCES
TI - FORMULATION AND EVALUATION OF METRONIDAZOLE BIOADHESIVE MATRICES FOR
TREATMENT OF PERIODONTITIS
VL - 33
Y2 - 6
ID - 15755
ER -
TY - JOUR
AB - Metronidazole (Mz) (an anaerobic antibacterial agent) was incorporated into
different bioadhesive matrices including gels and films using carbopol 934p (4%),
chitosan (3%) and hydroxypropyl methyl cellulose (HPMC) (3%). Penetration enhancers
including menthol (1%) or oleic acid (OA) (5%, 10%) were incorporated in such
formulations. The bioadhesive forces of the prepared matrices were determined and
expressed as detachment stresses (Dyne/cm2). Permeability of Mz across ear rabbit
skin and enhancement ratios (ER) were studied. The effects of selected Mz
formulations on the healing rate of experimentally induced periodontitis in guinea
pigs were estimated and histologically compared between treated and control groups.
The obtained results showed that the gel formulations containing carbopol 934p
exhibited maximum bioadhesive force with detachment stress equals to 66.98x102
dyne/cm2 followed by those containing chitosan (42.45x102 dyne/cm2) and HPMC
(26.41x102 dyne/cm2). There was a statistically significant difference (P< 0.05)
between the detachment stresses of gel formulations containing penetration
enhancers and the corresponding ones without penetration enhancer. HPMC based films
had bioadhesive force (19.33, 16 and 13.67×102 dyne/cm2) higher than those based on
chitosan (5.33 and 7.33x102 dyne/cm2).
AN - rayyan-563560642
AU - Ramadan, E.
AU - Borg, Th
AU - El Hawary, Y. M.
AU - Saleh, N. M.
KW - adhesive agent
bioadhesive matrix
carbomer
chitosan
menthol
methanol
metronidazole
oleic acid
unclassified drug
animal cell
animal experiment
animal model
animal tissue
article
cell membrane permeability
controlled study
detachment stress
drug formulation
drug penetration
drug screening
film coating
gel
guinea pig
histopathology
nonhuman
periodontitis
Leporidae
shear stress
skin permeability
wound healing
LA - English
PY - 2010
SN - 1110-0052
SP - 79-95
ST - Formulation and evaluation of metronidazole bioadhesive matrices for
T2 - Bull. Pharm. Sci.
TI - Formulation and evaluation of metronidazole bioadhesive matrices for
VL - 33
ID - 14016
ER -
TY - JOUR
AB - The surgical removal of third molar is the commonly performed procedure in
oral and maxillofacial surgery. It takes several days to recover from the
complications following removal of the third molar. The common postoperative
complications are pain, swelling, trismus, alveolar osteitis after third molar
removal . The aim of this systematic review was to thoroughly anal-yse the existing
literature to evaluate the effect of intra socket versus extra socket application
of hyaluronic acid gel in management of postoperative complications after third
molar removal. The objective of this systematic review is to assess the efficacy of
intra socket versus extra socket application of hyaluronic acid gel compared to
placebo or no treatment in management of post-operative complications after removal
of third molar.The data bases of PubMed, Cochrane and google scholar were searched
for the related topics along with a complimentary manual search of all oral surgery
journals till October 2018.The data collection form was based on analysis of
included studies for their quality assessment and publication bias.The primary
outcome measure was post-operative pain and the secondary outcome measures were
post-operative swelling & post-operative mouth opening. Three articles were
selected based on the inclusion criteria. The included studies were randomized
controlled trials. The clinical evidence from this review shows hyaluronic acid gel
application is found to be beneficial in reducing pain, swelling & tris-mus after
surgical removal of third molar. After contemplating its pivotal role in various
anti-inflammatory diseases, it is prudent to consider as an alterna-tive in
managing postoperative sequelae of third molar removal.
AN - rayyan-563560081
AU - Ramakrishnan, D. S.
AU - Gouthaman, S. S.
AU - Kandamani, J.
AU - Periasamy, S.
DO - 10.26452/ijrps.v11i4.3289
IS - 4
chlorhexidine
fibrin
gel
hyaluronic acid
hydroxyapatite
minocycline
steroid
tetracycline
bleeding
bone defect
cell migration
drug efficacy
fibroblast
fracture healing
gingivitis
granulation tissue
human
inflammation
lymphocyte
macrophage
mandible
molar tooth
nerve injury
neutrophil
osteitis
osteolysis
outcome assessment
pain
periodontitis
postoperative complication
practice guideline
quality of life
review
surgical flaps
swelling
systematic review
tooth extraction
tooth socket
trismus
visual analog scale
LA - English
PY - 2020
SN - 0975-7538
SP - 6155-6163
ST - Efficacy of hyaluronic acid gel in management of post-operative complications
after removal of third molar-a systematic review
TI - Efficacy of hyaluronic acid gel in management of post-operative complications
after removal of third molar-a systematic review
VL - 11
ID - 13455
ER -
TY - COMP
AB - BACKGROUND: Chemically modified tetracyclines (CMTs), devoid of antimicrobial
activity, inhibit pathologically elevated collagenase activity both in vivo and in
vitro. In the current study, doxycycline and 5 different CMTs were tested to
prevent matrix metalloproteinase (MMP)-dependent periodontal tissue breakdown in an
animal model of periodontitis. METHODS: Adult male rats received intragingival
injections with either 10 microl of physiologic saline or Escherichia coli
endotoxin (1 mg/ml) every other day for 6 days and were distributed into 8
treatment groups (12 rats/group): saline (S), endotoxin alone (E), E + CMT-1, E +
CMT-3, E + CMT-4, E + CMT-7, E + CMT-8, and doxycycline. All animals were treated
daily with 1 ml of 2% carboxymethyl cellulose (CMC) alone or containing one of the
above-mentioned CMTs (2 mg/day) orally. The gingival tissues were removed,
extracted, and assayed for gelatinase (GLSE). Some rat maxillary jaws from each
treatment group were fixed in buffered formalin and processed for histology and
immunohistochemistry for the cytokines tumor necrosis factor (TNF), interleukin
(IL)-1, and IL-6, and MMP-2 and MMP-9. RESULTS: Endotoxin injection induced
elevated GLSE activity (functional assay and osteoclast-mediated bone resorption),
the former identified as predominantly MMP-9 (92 kDa GLSE) by gelatin zymography.
All 6 tetracyclines (2 mg/day) inhibited periodontal breakdown in the following
order of efficacy: CMT-8 > CMT- 1 > CMT-3 > doxycycline > CMT-4 > CMT-7.
Immunohistochemistry was positive for TNF, IL-1, and IL-6 in the inflammatory cells
from untreated endotoxin rat tissues, whereas treatment with CMTs decreased the
number of immuno-positive stained cells for cytokines and MMPs. The in vivo
efficacy of these drugs varied with CMT structure and was significantly correlated
with bone resorption: r2 = -0.77, P<0.01; gelatinase inhibitory activity: r2 = -
0.84, P <0.01; and serum drug concentrations. CONCLUSION: Since both conventional
(antimicrobial) and non-antimicrobial tetracyclines inhibited periodontal bone
resorption induced by endotoxin injection, MMP-mediated bone loss in this model can
be prevented by inhibition of MMPs.
AN - rayyan-563561381
AU - Rifkin, B. R.
AU - Greenwald, R. A.
AU - Xu, J. W.
AU - Liu, Y.
AU - Turner, G.
AU - Golub, L. M.
AU - Vernillo, A. T.
CY - United States
DO - 10.1902/jop.2002.73.7.726
ET - 7
J2 - J Periodontol
KW - Alveolar Bone Loss/chemically induced/*drug therapy/*enzymology
Animals
Anti-Bacterial Agents/pharmacology/therapeutic use
Disease Models, Animal
Doxycycline/pharmacology/therapeutic use
Endotoxins
Gelatinases/*antagonists & inhibitors
Immunoenzyme Techniques
Interleukins/analysis
Male
Periodontitis/chemically induced/*drug therapy/*enzymology
Protease Inhibitors/*pharmacology
Rats
Tetracyclines/*pharmacology/therapeutic use
Tumor Necrosis Factor-alpha/analysis
LA - eng
N1 - State University of New York at Stony Brook, Department of Oral Biology and
Pathology, School of Dental Medicine, 11794-8702, USA. nramamur@epo.hsc.sunysb.edu
PY - 2002
SN - 0022-3492 (Print)
SP - 726-34
ST - Inhibition of matrix metalloproteinase-mediated periodontal bone loss in
rats: a comparison of 6 chemically modified tetracyclines
TI - Inhibition of matrix metalloproteinase-mediated periodontal bone loss in
rats: a comparison of 6 chemically modified tetracyclines
VL - 73
Y2 - 7
ID - 14755
ER -
TY - JOUR
AN - rayyan-563562108
AU - Rifkin, B. R.
AU - Xu, J. W.
AU - Liu, Y.
AU - Turner, G.
AU - Golub, L. M.
DO - 10.1902/jop.2002.73.7.726
IS - 7
PY - 2002
SP - 726-734
ST - Inhibition of matrix metalloproteinase-mediated periodontal bone loss in
rats: A comparison of 6 chemically modified tetracyclines
TI - Inhibition of matrix metalloproteinase-mediated periodontal bone loss in
rats: A comparison of 6 chemically modified tetracyclines
0036045743&doi=10.1902%2fjop.2002.73.7.726&partnerID=40&md5=7b8e1740d83f303374dcbb2
a7ce08912
VL - 73
ID - 15482
ER -
TY - JOUR
AB - Recent studies have demonstrated that tetracyclines (TCs) scavenge reactive
oxygen species (ROS). Hypochlorous acid (HOCl), an ROS produced by neutrophils, has
been shown to activate neutrophil procollagenase. The objective of the present
study was to determine whether (1) HOCl also activated osteoblast procollagenase
and (2) TCs inhibited this enzyme in the presence of HOCl. HOCl (5 μM) activated
the proenzyme approximately sixfold (P < 0.01) from the medium of PTH-treated UMR-
106-01 osteoblastic osteosarcoma cells as determined by functional collagenase
assay (3H- methyl-labeled collagen substrate). Doxycycline (50-400 μM) and
chemically modified tetracycline, CMT-1 (100-400 μM), significantly inhibited
collagenase activity 50-90% and 40-80%, respectively, in the presence of 5 μM HOCl.
Concentrations of 6-25 μM doxycycline and 10-50 μM CMT-1 had no significant effect.
Furthermore, an excess concentration of cation (50 mM CaCl2 or 50 μM ZnCl2) added
to the incubation mixtures containing either doxycycline or CMT-1 did not restore
collagenase activity, as demonstrated by SDS-PAGE-fluorography. These data
suggested that TCs reduced available HOCl and thus prevented the hypochlorous acid
conversion of the osteoblast proenzyme to active collagenase. TCs may have
therapeutic potential in the treatment of periodontitis and other diseases by
several mechanisms that inhibit pathologic collagen breakdown.
AN - rayyan-563561085
AU - Lee, H. M.
AU - Sorsa, T.
AU - Golub, L. M.
AU - Rifkin, B. R.
IS - 10
KW - 4 dedimethylaminotetracycline
calcium chloride
cmt 1
collagen
collagenase
doxycycline
hypochlorous acid
oxygen
parathyroid hormone
procollagenase
scavenger
unclassified drug
zinc chloride
animal cell
article
controlled study
enzyme activation
enzyme inhibition
fluorography
nonhuman
osteoblast
osteosarcoma
periodontitis
rat
LA - English
PY - 1993
SN - 0884-0431
SP - 1247-1253
ST - Reactive oxygen species activate and tetracyclines inhibit rat osteoblast
collagenase
T2 - J. BONE MINER. RES.
TI - Reactive oxygen species activate and tetracyclines inhibit rat osteoblast
collagenase
VL - 8
ID - 14459
ER -
TY - JOUR
AB - Introduction: Periodontal disease is an outcome of a plethora of molecular
mechanisms associated with oxidative stress, inflammation and oral microorganisms
is managed by surgical or non surgical therapies with systemic antibiotics.
However, local drug delivery system is known to augment the currently available
therapies and improves prognosis. Although, there are several local drug delivery
systems available, the search for an ideal agent with antioxidant, antimicrobial
and anti-inflammatory properties continues. Moringa oleifera Lam extracts is one
such wonder plant with all the above mentioned effects. Aim: To formulate an in-
situ thermoreversible gel with Moringa oleifera Lam extract that could be used as a
local drug delivery system as an adjunct to periodontal treatment. Materials and
Methods: This in-vitro study was conducted in Nanotechnology Laboratory, Department
of Pharmacology at Saveetha Dental College, from May 2022 to June 2022. For
preparation of thermoreversible gel the 19% of thermogelling polymer poloxamer 407
(15% to 30%w/v) which the least concentration that demonstrates
thermoreverisibility at 36 degrees C and 0.2% which is the least concentration of
mucoadhesive polymer carbapol 934 (0.2% to 0.5% w/v) which forms sol-gel transition
and 5% aqueous extract of Moringa oleifera and cold deionised water were used.
Surface pH, gelation temperature, syringeability, in-vitro drug release, stability,
gelation time and Fourier Transform Infrared Spectroscopy (FTIR) analysis was done.
Results: The surface pH of the gel was 6.94 +/- 0.091 with a gelation temperature
of 34 degrees C +/- 0.5. The gel was flowable with good stability and fast release
of eight hours. The chemical components compatability study of Moringa oleifera Lam
powder, thermoreversible gel without extract and thermoreversible gel with extract
were subjected to FITR analysis. The spectral analysis showed no significant
chemical interaction between the Moringa oleifera and thermoreversible gel.
Conclusion: The study concluded that the thermoreversible gel with Moringa oleifera
Lam extracts could be used as an adjunct for the management of periodontal disease
with good bioavailability. However, future clinical studies have to be conducted to
validate the results of the present study.
AN - rayyan-563562321
AU - Ramamurthy, S. P.
AU - Sekar, P.
AU - Than, A. U.
AU - Varghese, S.
AU - Kadhiresan
DO - 10.7860/JCDR/2022/58589.17206
IS - 12
PY - 2022
SN - ["2249-782X", "0973-709X"]
SP - ZC1-ZC6
ST - Formulation of In-situ Thermoreversible Gel with Moringa oleifera Lam Extract
as a Local Drug Delivery System for Adjunct Periodontal Treatment
T2 - JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
TI - Formulation of In-situ Thermoreversible Gel with Moringa oleifera Lam Extract
VL - 16
Y2 - 12
ID - 15695
ER -
TY - JOUR
AB - Introduction: Periodontal disease is an outcome of a plethora of molecular
mechanisms associated with oxidative stress, inflammation and oral microorganisms
is managed by surgical or non surgical therapies with systemic antibiotics.
However, local drug delivery system is known to augment the currently available
therapies and improves prognosis. Although, there are several local drug delivery
systems available, the search for an ideal agent with antioxidant, antimicrobial
and anti-inflammatory properties continues. Moringa oleifera Lam extracts is one
such wonder plant with all the above mentioned effects. Aim: To formulate an in-
situ thermoreversible gel with Moringa oleifera Lam extract that could be used as a
local drug delivery system as an adjunct to periodontal treatment. Materials and
Methods: This in-vitro study was conducted in Nanotechnology Laboratory, Department
of Pharmacology at Saveetha Dental College, from May 2022 to June 2022. For
preparation of thermoreversible gel the 19% of thermogelling polymer poloxamer 407
(15% to 30%w/v) which the least concentration that demonstrates
thermoreverisibility at 36°C and 0.2% which is the least concentration of
mucoadhesive polymer carbapol 934 (0.2% to 0.5% w/v) which forms sol-gel transition
and 5% aqueous extract of Moringa oleifera and cold deionised water were used.
Surface pH, gelation temperature, syringeability, in-vitro drug release, stability,
gelation time and Fourier Transform Infrared Spectroscopy (FTIR) analysis was done
Results: The surface pH of the gel was 6.94±0.091 with a gelation temperature of
34°C±0.5. The gel was flowable with good stability and fast release of eight hours.
The chemical components compatability study of Moringa oleifera Lam powder,
thermoreversible gel without extract and thermoreversible gel with extract were
subjected to FITR analysis. The spectral analysis showed no significant chemical
interaction between the Moringa oleifera and thermoreversible gel. Conclusion: The
study concluded that the thermoreversible gel with Moringa oleifera Lam extracts
could be used as an adjunct for the management of periodontal disease with good
bioavailability. However, future clinical studies have to be conducted to validate
the results of the present study.
AN - rayyan-563559790
AU - Ramamurthy, S. P.
AU - Sekar, P.
AU - Ulaganathan, A.
AU - Varghese, S.
AU - Kadhiresan
DO - 10.7860/JCDR/2022/58589.17206
IS - 12
KW - spectrometer
carbomer
deionized water
poloxamer
polymer
aqueous solution
article
bioavailability
chemical interaction
cold stress
drug formulation
drug release
drug stability
gelation
in vitro study
Moringa oleifera
nanotechnology
periodontal disease
pH
powder
sol-gel
visual analog scale
LA - English
PY - 2022
SN - ["0973-709X", "2249-782X"]
SP - ZC01-ZC06
ST - Formulation of In-situ Thermoreversible Gel with Moringa oleifera Lam Extract
TI - Formulation of In-situ Thermoreversible Gel with Moringa oleifera Lam Extract
VL - 16
ID - 13164
ER -
TY - JOUR
AN - rayyan-563561733
AU - Ramanauskaite, E.
AU - MacHiulskiene, V.
DO - 10.1186/s12903-020-01127-1
IS - 1
PY - 2020
ST - Antiseptics as adjuncts to scaling and root planing in the treatment of
periodontitis: A systematic literature review
T2 - BMC Oral Health
TI - Antiseptics as adjuncts to scaling and root planing in the treatment of
periodontitis: A systematic literature review
85084787871&doi=10.1186%2fs12903-020-01127-
1&partnerID=40&md5=64264a24da154e575e9dc488610206d6
VL - 20
ID - 15107
ER -
TY - JOUR
AB - Background: The subgingival application of sodium hypochlorite and
crosslinked hyaluronic acid gels has been recently proposed as a novel modality to
additionally enhance the outcomes of non-surgical periodontal therapy. The aim of
this prospective case series was to evaluate the clinical outcomes obtained with
subgingival application of sodium hypochlorite and crosslinked hyaluronic acid gels
in conjunction with non-surgical periodontal therapy. Description of the procedure:
Twenty systemically healthy, nonsmoking patients (14 females and 6 males; 47.2 ±
12.4 years of age) diagnosed with stage II-III periodontitis underwent full-mouth
scaling and root planing (SRP) performed with ultrasonic and hand instruments. All
teeth with probing depths (PD) ≥ 5 mm were treated with sodium hypochlorite gel
(Perisolv, Regedent AG, Zürich, Switzerland) instilled in the periodontal pockets
prior to and during SRP (2-3 times). Following mechanical debridement, crossliked
hyaluronic acid gel (Hyadent BG, Regedent AG Zürich, Switzerland) was applied in
the pockets.The outcomes were assessed at baseline and at 3 months after therapy.
The primary outcome variable was PD reduction while the secondary outcome variables
were changes in clinical attachment level (CAL), bleeding on probing (BOP) and
plaque index (PI). Outcomes: At 3 months the PD reduction measured 2.37 ± 0.6 mm,
while mean CAL gain amounted to 2.21 ± 0.54 mm (p < 0.001). Mean BOP decreased from
76.9% ± 15.3% at baseline to 26.7% ± 9.6% (p < 0.001) at 3 months and mean PI
decreased from 52.2% ± 14.0% at baseline to 15.3% ± 9.3% at 3 months (p < 0.001).
Conclusions: The combination of sodium hypochlorite and crosslinked hyaluronic acid
adjunctive to subgingival mechanical debridement may represent a valuable approach
to improve the outcomes of nonsurgical periodontal treatment.
AN - rayyan-563559836
AU - Ramanauskaite, E.
AU - Sakalauskaite, U.
AU - Ramanauskaite, A.
AU - Machiulskiene, V.
AU - Sculean, A.
DO - 10.1111/jcpe.13637
hypochlorite sodium
adult
bleeding on probing
case study
child
clinical article
clinical evaluation
clinical outcome
conference abstract
cross linking
drug combination
female
human
male
middle aged
mouth
outcome assessment
outcome variable
periodontal pocket
periodontitis
periodontium
preschool child
prospective study
root planing
Switzerland
ultrasound
LA - English
PY - 2022
SN - 1600-051X
SP - 295
ST - Clinical evaluation of a novel combination of sodium hypochlorite and
crosslinked hyaluronic acid adjunctive to non-surgical periodontal treatment: A
case series
TI - Clinical evaluation of a novel combination of sodium hypochlorite and
crosslinked hyaluronic acid adjunctive to non-surgical periodontal treatment: A
case series
VL - 49
ID - 13210
ER -
TY - JOUR
AB - Objective The objective of the present clinical study was to assess the
effect of the use of a dentifrice containing triclosan on periimplant mucositis in
subjects that had been restored with dental implants. Methods: The trial was
designed as a double-blind, randomized, two-treatment, parallel-group clinical
study. Sixty male and female subjects, aged 30-70 years, were recruited. All
subjects had lost teeth due to periodontal disease, and had been restored with a
minimum of two implants at least one year prior to the start of the trial. Subjects
were randomly assigned to two treatment groups. The subjects in the test group
(Test) brushed their teeth and implant-supported restorations with a dentifrice
containing triclosan, while the control subjects brushed with a sodium fluoride
dentifrice. Only subjects with a minimum of one implant site showing clinical signs
of peri-implant mucositis, i.e., bleeding after probing, were enrolled in the
study. Clinical examinations were performed at' baseline, and after three and six
months. The following parameters were scored: Probing pocket depth (PPD), bleeding
on probing (BoP), and plaque. The change from baseline within each treatment group
at three months and six months was evaluated for all parameters using ANOVA and
ANCOVA. Results: Subjects with peri-implant mucositis who used a dentifrice
containing 0.3% triclosan, as an adjunct to mechanical tooth brushing, exhibited
significantly fewer clinical signs of inflammation than subjects who used a regular
fluoride dentifrice at six months. The BoP scores were reduced from 53.8% to 29.1%
in the Test group, whereas in the same interval there was an increase from 52.3% to
58.8% in the Control group. Furthermore, the individual mean PPD, as well as the
frequency of sites with 5 mm and > 6 mm deep pockets, were reduced significantly
more in the Test than in the Control group. Conclusion: The regular use of a
dentifrice containing triclosan may reduce the clinical signs of inflammation in
the mucosa adjacent to dental implants.
AN - rayyan-563560655
AU - Ramberg, P.
AU - Lindhe, J.
AU - Botticelli, D.
AU - Botticelli, A.
IS - 3
KW - fluoride
silicic acid
toothpaste
triclosan
adult
aged
article
clinical trial
controlled study
drug mixture
female
human
male
middle aged
mucosa inflammation
periodontics
tooth implantation
tooth plaque
treatment outcome
LA - English
PY - 2009
SN - 0895-8831
SP - 103-107
ST - The effect of a triclosan dentifrice on mucositis in subjects with dental
implants: A six-month clinical study
T2 - J. Clin. Dent.
TI - The effect of a triclosan dentifrice on mucositis in subjects with dental
implants: A six-month clinical study
VL - 20
ID - 14029
ER -
TY - JOUR
AN - rayyan-563562455
AU - Rams, T. E.
AU - Slots, J.
DO - 10.1111/j.1600-0757.1996.tb00072.x
PY - 1996
SN - 0906-6713
SP - 139-159
ST - Local delivery of antimicrobial agents in the periodontal pocket
TI - Local delivery of antimicrobial agents in the periodontal pocket
VL - 10
ID - 15829
ER -
TY - JOUR
AB - Currently, periodontitis is treated by oral dosage forms (antibiotics) which
shows systemic side effects and failed to reach the therapeutic concentration
(above minimum inhibitory concentration, MIC) in the periodontal pocket. The
present study aimed to overcome the above issues, by designing tailored doxycycline
hyclate laden in situ gel by Poloxamer 407, chitosan, and polyethylene glycol 600.
The in situ gel-forming system has attracted attention owing to its ability of
sustained drug release above MIC, easy administration (syringeability), and high
drug retention (localization) in the periodontal cavity. The Box-Behnken design
(BBD) was used to tailor and optimize the concentration of Poloxamer 407 (X1 =
14.3%), chitosan (X2 = 0.58%), and polyethylene glycol 600 (X3 = 1.14%) to achieve
sufficient syringeability (149 N), t90% (1105 min), and viscosity at non-
physiological condition (512 cps) and physiological condition (5415 cps). The
optimized in situ gel was clear and isotonic (RBCs test). The gelation temperature
of the optimized in situ was 34 ± 1°C with sufficient mucoadhesive strength (26 ± 2
dyn/cm2), gel strength (29 ± 2 sec), and texture profile for periodontal
application. The in vitro drug release studies showed sustain release from
optimized in situ gel (24h) in comparison to marketed gel (7h). The antimicrobial
activity (cup plate technique) of the in situ gel was equivalent to the marketed
doxycycline gel, which suggests that the doxycycline hyclate retained its
antimicrobial efficacy when formulated as in situ gelling system. In conclusion,
BBD was effectively utilized to optimize in situ gel with minimum level of polymers
to achieve the required characteristics of the in situ gel for sustaining drug
delivery to treat periodontitis.
AN - rayyan-563560003
AU - Ranch, K. M.
AU - Maulvi, F. A.
AU - Koli, A. R.
AU - Desai, D. T.
AU - Parikh, R. K.
AU - Shah, D. O.
DO - 10.1208/s12249-021-01950-x
IS - 3
KW - viscometer
chitosan
doxycycline
doxycycline hyclate
gel
macrogol
macrogol 6000
poloxamer
article
controlled study
data analysis
drug release
drug retention
gelation
in vitro study
nonhuman
periodontitis
pH
priority journal
statistical model
temperature
viscosity
doxirobe
LA - English
PY - 2021
SN - 1530-9932
ST - Tailored Doxycycline Hyclate Loaded In Situ Gel for the Treatment of
Periodontitis: Optimization, In Vitro Characterization, and Antimicrobial Studies
TI - Tailored Doxycycline Hyclate Loaded In Situ Gel for the Treatment of
Periodontitis: Optimization, In Vitro Characterization, and Antimicrobial Studies
VL - 22
ID - 13377
ER -
TY - JOUR
AN - rayyan-563561788
AU - Rangabhatla, A. S. L.
AU - Boonrat, O.
AU - Hirun, N.
AU - Ouiyangkul, P.
DO - 10.1007/s13726-017-0569-2
IS - 11
PY - 2017
SP - 851-859
ST - Novel in situ mucoadhesive gels based on Pluronic F127 and xyloglucan
containing metronidazole for treatment of periodontal disease
T2 - Iranian Polymer Journal (English Edition)
TI - Novel in situ mucoadhesive gels based on Pluronic F127 and xyloglucan
containing metronidazole for treatment of periodontal disease
85034217491&doi=10.1007%2fs13726-017-0569-
2&partnerID=40&md5=96d1aa839f451fdc795ae4f2c0a90760
VL - 26
ID - 15162
ER -
TY - JOUR
AB - Simvastatin (SMV) are specific competitive inhibitors which are widely used
to lower cholesterol for the treatment of hyperlipidemia and arteriosclerosis. They
have shown to modulate bone formation by increasing the expression of bone
morphogenetic protein-2, inflammation, and angiogenesis,3 thus providing a new
direction in the field of periodontal therapy. The aim of this randomized trial was
to assess the clinical and radiographic effects of 1.2% Simvastatin gel as an
adjunct to scaling and root planing in the treatment of chronic periodontitis. The
IL-6 level in the sulcular epithelium was also evaluated before and after treatment
with 1.2% simvastatin. 60 sites were selected with minimum one intrabony defect and
probing pocket depth of >5mm and were divided into 2 groups; 30 sites were treated
with SRP and placebo (Group A) and 30 sites were treated with SRP along with
Simvastatin (SMV) (group B). Clinical parameters recorded at baseline before SRP
and at 60th, 90th and 180th day; included plaque index (PI), modified sulcus
bleeding index (mSBI), probing depth (PD), and clinical attachment level (CAL).
Radiologic assessment of intrabony defect (IBD) fill was done at baseline and after
6 months using computer-aided software. Interleukin-6- mRNA (IL-6-mRNA) levels in
sulcular epithelium was analysed for Group B at baseline and 3 months after the
drug application. Both therapies resulted in significant improvements in the
parameters however SRP along with simvastatin showed statistically significant
decrease in PI, mSBI and PD and gain in CAL at 6 months. In Group B, there was
greater decrease in mean IBD as compared to Group A. At the molecular level the
simvastatin group showed a significant decrease in IL-6-mRNA levels. The
statistically significant improvement in clinical and hard tissue parameters at
sites treated with SRP plus locally delivered SMV as well as its potency in
reducing IL-6-mRNA levels proved the efficacy of the drug as a local drug delivery
system in the treatment of chronic periodontitis not only in clinical but as well
as in molecular level.
AN - rayyan-563560513
AU - Rath, A.
AU - Mahenra, J.
AU - Thomas, L.
AU - Sandhu, M.
AU - Namasi, A.
AU - Ramakrishna, T.
IS - 1
KW - genomic DNA
interleukin 6
messenger RNA
placebo
simvastatin
adult
article
bone defect
clinical feature
controlled study
drug potency
drug tolerability
female
gene
gingiva bleeding
human
IL6 gene
male
medical parameters
mouth hygiene
scoring system
tooth radiography
treatment outcome
LA - English
PY - 2012
SN - 0975-4415
SP - 70-81
ST - A clinical, radiological and IL-6 evaluation of subgingivally delivered
simvastatin in the treatment of chronic periodontitis
T2 - Intl. J. Drug Deliv.
TI - A clinical, radiological and IL-6 evaluation of subgingivally delivered
simvastatin in the treatment of chronic periodontitis
VL - 4
ID - 13887
ER -
TY - JOUR
AB - Introduction: The idea of Full-Mouth Disinfection (FMD) was presented in the
early 1990s, the traditional method of treating periodontal disease, quadrant by
quadrant over several visits. The FMD method has been recommended with a number of
changes over time. Triphala, Ayurvedic medicinal herbal formulations is also useful
in dentistry as antiplaque, antimicrobial, antioxidant, analgesic, antipyretic and
anti-inflammatory agent. As Chlorhexidine (CHX) is used from past years for full
mouth disinfection, there is need to evaluate the efficacy of CHX as well as
Triphala in diabetic mellitus patients.Need of the study: As CHX has been used for
years to disinfect the entire mouth, a study comparing the effectiveness of CHX and
Triphala in individuals with Diabetes Mellitus (DM) for full mouth disinfection
will be done.Aim: To evaluate and compare the efficacy of triphala and CHX in the
treatment of Stage-II and III periodontitis with one stage complete mouth
disinfection in Type-IIDM patients.Materials and Methods: This experimental study
will be done in Sharad Pawar dental College, department of Periodontics after
obtaining the ethical clearance during September 2021 to September 2022. About 24
type 2 diabetic subjects with Stage -II and Stage-III periodontitis, will be
randomly divided into test Group-And control group with 12 in each group. In Group-
A, Full mouth disinfection will be done using CHX and in Group-B full mouth
disinfection will be done using Triphala. After full mouth subgingival scaling and
root planning, patient will brush the dorsum of the tongue for one minute with gel,
the mouth will be rinsed two times with mouthwash for one minute, the pharynx will
be cleaned with a spray, and all periodontal pockets will be irrigated (thrice
within 10 minutes) with a gel. Clinical parameters will be evaluated at baseline
and six months. The clinical parameters are Probing Pocket Depth (PPD), Plaque
Index (PI), Clinical Attachment Level (CAL), Papillary Bleeding Index (PBI). Paired
t-test will be used to compare data within group for before and after treatment and
unpaired t-test will be used to compare between the groups.
AN - rayyan-563562459
AU - Rathod, A.
AU - Jaiswal, P.
AU - Bajaj, P.
AU - Masurkar, D.
AU - Chitlange, P.
DO - 10.7860/JCDR/2023/57991.17701
IS - 4
PY - 2023
SN - ["2249-782X", "0973-709X"]
SP - ZK9-ZK11
ST - Comparative Evaluation of Effectiveness of Triphala and Chlorhexidine in One
Stage Full Mouth Disinfection Treatment of Stage-II and III Periodontitis in Type-
II Diabetes Mellitus Patients- A Research Protocol
T2 - JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
TI - Comparative Evaluation of Effectiveness of Triphala and Chlorhexidine in One
Stage Full Mouth Disinfection Treatment of Stage-II and III Periodontitis in Type-
II Diabetes Mellitus Patients- A Research Protocol
VL - 17
Y2 - 4
ID - 15833
ER -
TY - JOUR
AB - Background: Topical application of active substances offers an additional
option in periodontal therapy. The aim of this study was to examine the influence
of the administration of a novel, biodegradable 14% doxycycline gel on
microbiological findings, in connection with scaling and root planing. Methods: One
hundred ten patients in three centers (Frankfurt and Heidelberg, Germany; Nijmegen,
The Netherlands) with moderate to advanced periodontitis were evaluated in this
randomized, double-masked, split-mouth clinical trial. In each patient, three test
teeth were randomly assigned to one of three treatment modalities: 1) scaling and
root planing (SRP) alone; 2) SRP with subgingival placebo gel (VEH); or 3) SRP and
14% doxycycline gel (DOX). Subgingival plaque samples were analyzed at baseline and
3 and 6 months after therapy for Actinobacillus actinomycetemcomitans (A.a.),
Tannerella forsythensis (T.f.), Porphyromonas gingivalis (P.g.), and Treponema
denticola (T.d.) using a RNA probe. Samples from 10 patients were tested for
resistance against doxycycline, amoxicillin/clavulanic acid, cefoxitin,
clindamycin, and metronidazole using agar diffusion testing. Results: The largest
decrease in pathogens was found after 3 months, with the most pronounced
differences between DOX and SRP (P<0.05). At 6 months, pathogens were still reduced
markedly in all groups. Treatment results were consolidated for VEH and DOX, with a
slight deterioration for SRP (DOX versus SRP: P<0.001). Resistance was observed to
amoxycillin/clavulanic acid, cefoxitin, clindamycin, and metronidazole (four
isolates) but not to doxycycline. Conclusion: The addition of subgingival
instillation of a 14% doxycycline gel resulted in pronounced reduction of
periodontal pathogens after 3 months and stabilizing results up to 6 months after
therapy. Resistance to doxycycline was not induced.
AN - rayyan-563560851
AU - Schacher, B.
AU - Bürklin, T.
AU - Böddinghaus, B.
AU - Holle, R.
AU - Renggli, H. H.
AU - Eickholz, P.
AU - Kim, T. S.
DO - 10.1902/jop.2005.76.1.66
IS - 1
KW - amoxicillin
cefoxitin
clavulanic acid
clindamycin
doxycycline
metronidazole
placebo
adult
agar diffusion
aged
article
biodegradability
clinical trial
controlled study
disease severity
drug formulation
drug response
female
human
male
microbiology
multicenter study
periodontal disease
periodontitis
RNA probe
sample
tooth plaque
treatment outcome
Treponema denticola
LA - English
PY - 2005
SN - 0022-3492
SP - 66-74
ST - Non-surgical periodontal therapy with adjunctive topical doxycycline: A
double-masked, randomized, controlled multicenter study. II. Microbiological
results
TI - Non-surgical periodontal therapy with adjunctive topical doxycycline: A
double-masked, randomized, controlled multicenter study. II. Microbiological
results
VL - 76
ID - 14225
ER -
TY - JOUR
AB - UNLABELLED: Green tea catechins had an in vitro antibacterial effect against
periodontopathic bacteria and were able to inhibit destruction of the periodontal
tissue. In this study, we aimed to evaluate the effect of locally delivered gel
containing green tea extract as an adjunct to non-surgical periodontal treatment.
Forty-eight subjects who had teeth with probing pocket depth of 5-10 mm were
randomly allocated into the test or control group. Probing pocket depth, clinical
attachment level, gingival index (GI), bleeding on probing (BOP) and full mouth
plaque score were measured at baseline. Subjects received oral hygiene instruction,
single episode of scaling and root planing and subgingival application of the green
tea gel (test group) or the placebo gel (control group). The gel was repeatedly
applied at 1 and 2 weeks later. The parameters were recorded again at the 1st, 3rd
and 6th month after the last gel application. The results showed that all
parameters were improved in both groups compared to baseline. The test group
exhibited significantly higher reduction in BOP at the 3rd month (p = 0.003) and
significantly lower GI at the 1st month (p < 0.001) and 3rd month (p < 0.001) when
compared with the control group. Thus, green tea gel could provide a superior
benefit in reducing bleeding on probing and gingival inflammation when used as an
adjunct to non-surgical periodontal treatment. ( TRIAL REGISTRATION: MU-IRB
2008/153.0511, ClinicalTrials.gov NCT00918060).
AN - rayyan-563560370
AU - Rattanasuwan, K.
AU - Rassameemasmaung, S.
AU - Sangalungkarn, V.
AU - Komoltri, C.
DO - 10.1007/s10266-014-0190-1
IS - 1
KW - NCT00918060
catechin
gel
plant extract
tea
clinical trial
dental scaling
female
human
male
middle aged
periodontal index
root planing
treatment outcome
LA - English
PY - 2016
SN - 1618-1255
SP - 89-97
ST - Clinical effect of locally delivered gel containing green tea extract as an
adjunct to non-surgical periodontal treatment
T2 - Odontology
TI - Clinical effect of locally delivered gel containing green tea extract as an
adjunct to non-surgical periodontal treatment
VL - 104
ID - 13744
ER -
TY - JOUR
AB - Purpose: This study aims to formulate and evaluate the temperature-sensitive
in situ gel of 0.5% (w/v) azithromycin (AZM) containing cyclodextrin inclusion
complex by the cold method. Method: To increase its aqueous solubility, it was
incorporated as an inclusion complex in a 1:1 M ratio with hydroxypropyl β-
cyclodextrin (HPβ-CD). The central composite design was used to optimize the effect
of poloxamer 407 and Carbopol 934P (independent factors) on dependent factors such
as percentage drug release at first hour (t50% and t90%), gelation temperature, and
viscosity. Both the independent factors had a significant effect on the entire five
response factors (p < 0.05). Each formulation was evaluated for clarity, pH,
spreadability, syringeability, gelation strength, mucoadhesive property, in vitro
drug release, gelation temperature, viscosity, and rheology. Result: Based on
maximum desirability, formulation containing 18.91% (w/v) of poloxamer 407 and
0.353% (w/v) of Carbopol 934P was considered an optimized batch. The value of
percentage relative error exhibited a close agreement between observed and
predicted values calculated using regression equations. Further, the optimized
formulation showed a good drug release for a period of 54 h, which was more
effective in the treatment of periodontal disease. Conclusion: Thus, azithromycin
(AZM) can be successfully formulated as a thermosensitive in situ mucoadhesive gel
containing HPβ-CD for periodontal drug delivery.
AN - rayyan-563560010
AU - Raval, M.
AU - Bagada, H.
DO - 10.1007/s12247-019-09422-3
IS - 1
KW - 2 hydroxypropyl beta cyclodextrin
azithromycin
cyclodextrin
poloxamer
article
cold stress
drug formulation
drug release
flow kinetics
gelation
in vitro study
pH
priority journal
temperature
viscosity
LA - English
PY - 2021
SN - ["1939-8042", "1872-5120"]
SP - 67-84
ST - Formulation and Evaluation of Cyclodextrin-Based Thermosensitive In Situ Gel
of Azithromycin for Periodontal Delivery
T2 - J. Pharm. Innov.
TI - Formulation and Evaluation of Cyclodextrin-Based Thermosensitive In Situ Gel
of Azithromycin for Periodontal Delivery
VL - 16
ID - 13384
ER -
TY - JOUR
AB - Objective: The objective of this study is to evaluate the comparative effect
of curcumin and ornidazole in treating chronic periodontitis. Materials and
Methods: Twenty individuals of both sexes aged between 27 and 53 years diagnosed
with chronic periodontitis and having pocket depths >5 mm bilaterally were selected
for this study, in a split-mouth design. Examination of plaque index, probing
pocket depth, and clinical attachment level was measured for each patient. The
patients received a complete prophylaxis including scaling and root planing after
which, both test gels were injected into the two experimental sites chosen, that
had probing depth (PD) >5 mm and were located in symmetric quadrants. Pocket PD,
clinical attachment loss, and plaque index were recorded at days 0 and 30. Results:
At 1-month evaluation, curcumin group showed a significant decrease in pocket PD,
plaque index, and clinical attachment loss when compared to the ornidazole group.
Conclusion: The results show a more favorable outcome with curcumin than ornidazole
gel, thus curcumin can be used as an adjunct to nonsurgical periodontal therapy.
AN - rayyan-563560287
AU - Ravishankar, P.
AU - Kumar, Y.
AU - Anila, E.
AU - Chakraborty, P.
AU - Malakar, M.
AU - Mahalakshmi, R.
DO - 10.4103/jphi.JPHI_82_17
IS - 4
KW - curcumin
curenext
ornidazole
ornigreat
adult
article
clinical article
controlled study
dental prophylaxis
dental scaling
drug efficacy
female
gel
human
local therapy
male
periodontal pocket
plaque index
root planing
treatment outcome
LA - English
PY - 2017
SN - ["2230-9713", "2230-973X"]
SP - 188-192
ST - Effect of local application of curcumin and ornidazole gel in chronic
periodontitis patients
TI - Effect of local application of curcumin and ornidazole gel in chronic
periodontitis patients
VL - 7
ID - 13661
ER -
TY - JOUR
AB - Alendronate sodium is formulated into gels and evaluated for the treatment of
bone resorptive lesions in periodontitis. Carbopol 934P was used for the
preparation of gels in three different concentrations. The prepared gel was
evaluated for various properties such as preformulation, content uniformity,
viscosity, compatibility, sterility, in vitro diffusion, and in vivo studies. The
drug and the polymer were found to be compatible and confirmed by Fourier transform
infrared spectroscopy. Viscosity of the gels increased with the increase in the
polymer concentration. The formulations were found to be sterile. In vitro release
study revealed that drug released from the gel follows non-Fickian diffusion
followed by first-order release. In vivo studies were carried out for 6 months in
patients. The results revealed a significant improvement in the clinical parameters
such as gingival index, probing pocket depth, clinical attachment level, and potent
inhibitory effect on bone resorption by inhibition of osteoclasts. In addition,
there was increase in the new bone formation. Copyright © Taylor & Francis Inc.
AN - rayyan-563560787
AU - Reddy, G. T.
AU - Kumar, T. M. P.
AU - Veena
DO - 10.1080/10717540590952663
IS - 4
carbomer
methyl paraben
propyl paraben
triethanolamine
water
adult
article
clinical article
controlled study
drug diffusion
drug formulation
drug sterility
gel
gingiva
human
in vitro study
in vivo study
ossification
osteoclast
osteolysis
parameters
periodontitis
priority journal
treatment outcome
viscosity
LA - English
PY - 2005
SN - ["1071-7544", "1521-0464"]
SP - 217-222
ST - Formulation and evaluation of alendronate sodium gel for the treatment of
bone resorptive lesions in periodontitis
T2 - Drug Deliv. J. Deliv. Targeting Ther. Agents
TI - Formulation and evaluation of alendronate sodium gel for the treatment of
bone resorptive lesions in periodontitis
VL - 12
ID - 14161
ER -
TY - JOUR
AB - BACKGROUND: Plantago commonly called as Isabgol (Plantago ovata Forssk.) is a
perennial herb that belongs to the family Plantaginaceae. A range of biological
activities has been found from plant extracts, including wound healing activity,
anti-inflammatory, analgesic, antioxidant, weak antibiotic, immunomodulating and
anti-ulcerogenic activity. Periodontal disease is a complex condition as a result
of interaction between microorganisms and host inflammatory mediators. Hence, the
extract of Isabgol is tested for its antibacterial and anti-inflammatory properties
against periodontal disease. AIM: The aim of this in vitro study is to evaluate the
antibacterial property of Isabgol leaves and seeds against periodontal pathogens,
namely Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella
intermedia, and Fusobacterium nucleatum and anti-inflammatory property against
matrix metalloproteinase-2 (MMP-2) and MMP-9. MATERIALS AND METHODS: In this in
vitro study, aqueous extract of Isabgol is tested for its antibacterial property
against the stock cultures of specified periodontal pathogens using the tube
dilution method and anti-inflammatory property against MMP-2 and MMP-9 using
zymogen gel electrography. RESULTS: Minimum concentration at which the sensitivity
of A. actinomycetemcomitans, P. gingivalis, P. intermedia, and F. nucleatum for the
extract observed was 50 μl/ml, 0.8 μl/ml, 0.4 μl/ml and 12.5 μl/ml, respectively,
concentrations below these showed no effect on the microorganisms. Zymogen
electrographic test for anti-inflammatory activity showed percentage inhibition of
30% and 40% against MMP-2 and MMP-9, respectively. CONCLUSION: Isabgol is effective
against the periodontal pathogens and inflammatory mediators which are responsible
for periodontal disease.
AN - rayyan-563560812
AU - Reddy, P. R. T.
AU - Vandana, K. V.
AU - Prakash, S.
DO - 10.4103/ayu.AYU_176_16
IS - 4
J2 - Ayu
LA - eng
N1 - Department of Periodontics, College of Dental Sciences, Davangere, Karnataka,
India.; Department of Periodontics, College of Dental Sciences, Davangere,
Karnataka, India.; Department of Periodontics, College of Dental Sciences,
Davangere, Karnataka, India.
PY - 2018
SN - 0974-8520 (Print)
SP - 226-229
ST - Antibacterial and anti-inflammatory properties of Plantago ovata Forssk.
leaves and seeds against periodontal pathogens: An in vitro study
T2 - Ayu
TI - Antibacterial and anti-inflammatory properties of Plantago ovata Forssk.
leaves and seeds against periodontal pathogens: An in vitro study
VL - 39
Y2 - 10
ID - 14186
ER -
TY - CONF
AN - rayyan-563561732
AU - Regina, J.
AU - Astridtasya, A. P.
AU - Ningtyas, M. R. A.
AU - Alhasyimi, A. A.
AU - Rosyida, N. F.
DA - 2020
SP - 203-210
ST - Efficacy of papain-arginine gel on gingivitis treatment caused by orthodontic
appliances
TI - Efficacy of papain-arginine gel on gingivitis treatment caused by orthodontic
appliances
%2fKEM.829.203&partnerID=40&md5=4bdb75eeb4d91d6d8f3e14fad5625ab8
VL - 829
ID - 15106
ER -
TY - JOUR
AB - BACKGROUND AND OBJECTIVES: The purpose of this article was to summarize what
is known about the function of melatonin in the oral cavity. MATERIAL AND METHODS:
Databases were searched for the relevant published literature to 30 November, 2013.
The following search items were used in various combinations: melatonin, gingiva,
periodontium, inflammation, herpes, alveolar bone, periodontal ligament, dental
implants, xerostomia, methacrylate, chlorhexidine, cancer. The literature uncovered
is summarized herein. RESULTS: Salivary melatonin levels exhibit a circadian rhythm
with highest values at night. Melatonin has both receptor-mediated and receptor-
independent actions in cells of the oral cavity. Melatonin is released into the
saliva by the acinar cells of the major salivary glands and via the gingival fluid.
Functions of melatonin in the oral cavity are likely to relate primarily to its
anti-inflammatory and antioxidant activities. These actions may suppress
inflammation of the gingiva and periodontium, reduce alveolar bone loss, abrogate
herpes lesions, enhance osteointegration of dental implants, limit oral cancer, and
suppress disorders that have a free radical component. Sublingual melatonin tablets
or oral melatonin sprays and topical melatonin-containing gel, if used on a regular
basis, may improve overall oral health and reduce mucosal lesions. CONCLUSION:
Collectively, the results indicate that endogenously-produced and exogenously-
applied melatonin are beneficial to the oral cavity.
AN - rayyan-563560389
AU - Reiter, R. J.
AU - Rosales-Corral, S. A.
AU - Liu, X. Y.
AU - Acuna-Castroviejo, D.
AU - Escames, G.
AU - Tan, D. X.
DO - 10.1111/jre.12176
IS - 1
antioxidant
melatonin
scavenger
chemistry
circadian rhythm
human
mouth
mouth disease
pathophysiology
periodontium
physiology
saliva
LA - English
PY - 2015
SN - 1600-0765
SP - 9-17
ST - Melatonin in the oral cavity: physiological and pathological implications
TI - Melatonin in the oral cavity: physiological and pathological implications
VL - 50
ID - 13763
ER -
TY - JOUR
AB - Bone regeneration is a crucial part in the treatment of periodontal tissue
regeneration, in which new attempts come out along with the development of
nanomaterials. Herein, the effect of cerium oxide nanoparticles (CeO2 NPs) on the
cell behavior and function of human periodontal ligament stem cells (hPDLSCs) was
investigated. Results of CCK-8 and cell cycle tests demonstrated that CeO2 NPs not
only had good biocompatibility, but also promoted cell proliferation. Furthermore,
the levels of alkaline phosphatase activity, mineralized nodule formation and
expressions of osteogenic genes and proteins demonstrated CeO2 NPs could promote
osteogenesis differentiation of hPDLSCs. Then we chose electrospinning to fabricate
fibrous membranes containing CeO2 NPs. We showed that the composite membranes
improved mechanical properties as well as realized release of CeO2 NPs. We then
applied the composite membranes to in vivo study in rat cranial defect models.
Micro-CT and histopathological evaluations revealed that nanofibrous membranes with
CeO2 NPs further accelerated new bone formation. Those exciting results
demonstrated that CeO2 NPs and porous membrane contributed to osteogenic ability,
and CeO2 NPs contained electrospun membrane may be a promising candidate material
for periodontal bone regeneration.
AN - rayyan-563559905
AU - Ren, S.
AU - Zhou, Y.
AU - Zheng, K.
AU - Xu, X.
AU - Yang, J.
AU - Wang, X.
AU - Miao, L.
AU - Wei, H.
AU - Xu, Y.
DO - 10.1016/j.bioactmat.2021.05.037
KW - 3365
aluminum foil
caliper
culture medium
X-ray diffractometer
electron microscope
electrophoresis analyzer
flow cytometer
incubator
micro-CT scanner
microplate reader
microwell plate
Nano-ZS
OPTIMA530DV
PHI 5000
SpectraMax M3
spectrometer
S–3400 N II
Tecnai G2 Spirit Biotwin
trephine
tube
VivaCT 80
acetic acid
alcohol
alizarin red s
ascorbic acid
buffer
cerium nitrate
cerium oxide nanoparticle
complementary DNA
dexamethasone
dissolved oxygen
edetic acid
eosin
epoxy resin
formaldehyde
gelatin
glutaraldehyde
hematoxylin
hexafluoro 2 propanol
nitroblue tetrazolium
osmium tetraoxide
osteocalcin
osteopontin
pentobarbital
platinum
polycaprolactone
propidium iodide
riboflavin
ribonuclease
streptomycin
water
anesthesia
animal cell
animal experiment
animal model
animal tissue
article
biocompatibility
bone development
bone regeneration
bone volume
cell cycle
cell function
cell proliferation
cell viability
data analysis
electrospinning
flow cytometry
histology
histopathology
hydrophilicity
incubation time
male
membrane
nonhuman
optical density
protein expression
rat
room temperature
staining
thermostability
tissue engineering
ultraviolet irradiation
Western blotting
D8-ADVANCE
LA - English
PY - 2022
SN - 2452-199X
SP - 242-253
ST - Cerium oxide nanoparticles loaded nanofibrous membranes promote bone
regeneration for periodontal tissue engineering
T2 - Bioact. Mater.
TI - Cerium oxide nanoparticles loaded nanofibrous membranes promote bone
regeneration for periodontal tissue engineering
VL - 7
ID - 13279
ER -
TY - JOUR
AB - THE PURPOSE OF THE PRESENT STUDY was to compare an enzyme immunoassay with
culture samples from untreated and non-surgically treated periodontal pockets and
to assess the clinical and microbiological effects of citric acid irrigation as a
supplement to scaling and root planing. The enzyme immunoassay used in this study
is a chairside diagnostic tool aimed at identifying the presence of P. gingivalis,
P. intermedia, and A. actinomycetemcomitans. Six sites with pocket depths greater
than or equal to 6 mm In each of 16 patients were monitored for 24 weeks using
clinical and microbiological parameters. In two out of the six sites, scaling and
root planing was supplemented with subgingival citric acid irrigation of the pocket
after completion of the mechanical treatment. The sensitivity of the immunoassay in
relation to culture was calculated to 85.5% and the specificity to 90.2%. The
immunoassay corresponded to a detection level of 10(4) as estimated by culture.
Sites treated with a combination of scaling and irrigation with citric acid
demonstrated a similar healing pattern as sites treated with scaling and root
planing alone. The profile of the marker bacteria was almost parallel for the two
groups. The results of this investigation thus indicated that the immunoassay can
be used as a screening tool for selected periodontal pathogens and that adjunctive
irrigation with citric acid has no measurable clinical or microbiological effects.
AN - rayyan-563562552
AU - Renvert, S.
AU - Dahlen, G.
AU - Snyder, B.
DO - 10.1902/jop.1997.68.4.346
IS - 4
PY - 1997
SN - ["0022-3492", "1943-3670"]
SP - 346-352
ST - Clinical and microbiological effects of subgingival antimicrobial irrigation
with citric acid as evaluated by an enzyme immunoassay and culture analysis
TI - Clinical and microbiological effects of subgingival antimicrobial irrigation
with citric acid as evaluated by an enzyme immunoassay and culture analysis
VL - 68
Y2 - 4
ID - 15926
ER -
TY - JOUR
AB - Aim: This randomized clinical trial presents a 12-month follow-up of the
clinical and microbiological results after application of minocycline microspheres
as an adjunct to mechanical treatment of incipient peri-implant infections compared
with an adjunctive treatment using 1% chlorhexidine gel application. Material and
Methods: Thirty-two subjects with probing depth ≥4 mm, combined with bleeding
and/or exudate on probing and presence of putative pathogenic bacteria were given
oral hygiene instructions and mechanical treatment of infected areas adjacent to
implants. The subjects were then randomly assigned adjunctive subgingival
antimicrobial treatment using either chlorhexidine gel or minocycline microspheres.
Sixteen patients in the minocycline group and 14 in the chlorhexidine group
completed the study. Follow-up examinations were carried out after 10 days, 1, 2,
3, 6, 9 and 12 months. Results: The adjunctive use of minocycline microspheres
resulted in improvements of probing depths and bleeding scores, whereas the
adjunctive use of chlorhexidine only resulted in limited reduction of bleeding
scores. For the deepest sites of the treated implants in the minocycline group, the
mean probing depth was reduced from 5.0 to 4.4 mm at 12 months. This study could
not show any significant difference in the levels of bacterial species or groups at
any time point between the two antimicrobial agents tested. The present findings
encourage further studies on adjunctive use of minocycline microspheres in the
treatment of peri-implant lesions. Conclusions: The use of a local antibiotic as an
adjunct to mechanical treatment of incipient peri-implantitis lesions demonstrated
improvements in probing depths that were sustained over 12 months. © 2006 Blackwell
Munksgaard.
AN - rayyan-563560772
AU - Renvert, S.
AU - Lessem, J.
AU - Dahlén, G.
AU - Lindahl, C.
AU - Svensson, M.
DO - 10.1111/j.1600-051X.2006.00919.x
IS - 5
KW - bacterial DNA
chlorhexidine
drug derivative
microsphere
minocycline
adult
aged
anaerobic bacterium
article
bacterial count
clinical trial
controlled study
drug effect
gel
human
infection
microbiology
middle aged
periodontics
periodontitis
tooth implantation
tooth plaque
LA - English
PY - 2006
SN - ["0303-6979", "1600-051X"]
SP - 362-369
ST - Topical minocycline microspheres versus topical chlorhexidine gel as an
adjunct to mechanical debridement of incipient peri-implant infections: A
TI - Topical minocycline microspheres versus topical chlorhexidine gel as an
adjunct to mechanical debridement of incipient peri-implant infections: A
VL - 33
ID - 14146
ER -
TY - JOUR
AB - Aim: This randomized clinical trial presents a 12-month follow-up of the
clinical and microbiological results after application of minocycline microspheres
as an adjunct to mechanical treatment of incipient peri-implant infections compared
with an adjunctive treatment using 1% chlorhexidine gel application. Material and
Methods: Thirty-two subjects with probing depth >= 4 mm, combined with bleeding
and/or exudate on probing and presence of putative pathogenic bacteria were given
oral hygiene instructions and mechanical treatment of infected areas adjacent to
implants. The subjects were then randomly assigned adjunctive subgingival
antimicrobial treatment using either chlorhexidine gel or minocycline microspheres.
Sixteen patients in the minocycline group and 14 in the chlorhexidine group
completed the study. Follow-up examinations were carried out after 10 days, 1, 2,
3, 6, 9 and 12 months. Results: The adjunctive use of minocycline microspheres
resulted in improvements of probing depths and bleeding scores, whereas the
adjunctive use of chlorhexidine only resulted in limited reduction of bleeding
scores. For the deepest sites of the treated implants in the minocycline group, the
mean probing depth was reduced from 5.0 to 4.4 mm at 12 months. This study could
not show any significant difference in the levels of bacterial species or groups at
any time point between the two antimicrobial agents tested. The present findings
encourage further studies on adjunctive use of minocycline microspheres in the
treatment of peri-implant lesions. Conclusions: The use of a local antibiotic as an
adjunct to mechanical treatment of incipient peri-implantitis lesions demonstrated
improvements in probing depths that were sustained over 12 months.
AN - rayyan-563562540
AU - Renvert, S.
AU - Lessem, J.
AU - Dahlen, G.
AU - Lindahl, C.
AU - Svensson, M.
DO - 10.1111/j.1600-051X.2006.00919.x
IS - 5
PY - 2006
SN - ["0303-6979", "1600-051X"]
SP - 362-369
ST - Topical minocycline microspheres versus topical chlorhexidine gel as an
adjunct to mechanical debridement of incipient peri-implant infections: a
TI - Topical minocycline microspheres versus topical chlorhexidine gel as an
adjunct to mechanical debridement of incipient peri-implant infections: a
VL - 33
Y2 - 5
ID - 15914
ER -
TY - JOUR
AB - Background: Peri-implantitis is an inflammatory process caused by
microorganisms affecting the tissues around an osseointegrated implant in function,
resulting in a loss of supporting bone. Limited data exist regarding the treatment
of peri-implantitis. The aim of this study was to assess the clinical and
microbiologic outcome of repeated local administration of minocycline microspheres,
1 mg, in cases of peri-implantitis. Methods: Thirty-two subjects with at least one
implant with a probing depth ≥4 mm combined with bleeding and/or exudate on probing
and the presence of putative pathogenic bacteria were included in the study. At
baseline, subjects were randomly assigned to receive local minocycline microspheres
(17 subjects and 57 implants) or Chlorhexidine gel (15 subjects and 38 implants)
following debridement. Treatments were performed on three occasions: baseline and
days 30 and 90. Follow-up examinations were conducted at 10 days and at 1, 3, 6, 9,
and 12 months. Results: The use of minocycline resulted in significant improvements
in probing depths compared to Chlorhexidine at days 30, 90, and 180 (P= 0.5, P=
0.01, and P= 0.04, respectively). For the deepest sites of the minocycline-treated
implants, the mean probing depth reduction was 0.6 mm at 12 months. Regarding
bleeding on probing, significant differences between groups, based on all four
sites at the implants, were found at days 30, 90, 180, 270, and 360. Both
treatments resulted in a marked reduction in the indicator bacteria. Conclusions:
The use of a repeated local antibiotic as an adjunct to the mechanical treatment of
peri-implantitis lesions demonstrated improvements in probing depths that were
significantly different from controls and were sustained for 6 months. The
adjunctive use of minocycline microspheres is beneficial in the treatment of peri-
implant lesions, but the treatment may have to be repeated.
AN - rayyan-563560710
AU - Renvert, S.
AU - Lessem, J.
AU - Dahlén, G.
AU - Renvert, H.
AU - Lindahl, C.
DO - 10.1902/jop.2008.070347
IS - 5
KW - chlorhexidine
drug derivative
microsphere
minocycline
adult
aged
article
bacterial count
bacterium
classification
clinical trial
comparative study
controlled study
drug effect
female
follow up
gel
human
infection
male
microbiology
middle aged
nonparametric test
periodontics
periodontitis
retreatment
tooth implantation
LA - English
PY - 2008
SN - 0022-3492
SP - 836-844
ST - Mechanical and repeated antimicrobial therapy using a local drug delivery
system in the treatment of peri-implantitis: A randomized clinical trial
TI - Mechanical and repeated antimicrobial therapy using a local drug delivery
VL - 79
ID - 14084
ER -
TY - COMP
AB - BACKGROUND: Peri-implantitis is an inflammatory process caused by
1 mg, in cases of peri-implantitis. METHODS: Thirty-two subjects with at least one
implant with a probing depth > or =4 mm combined with bleeding and/or exudate on
probing and the presence of putative pathogenic bacteria were included in the
study. At baseline, subjects were randomly assigned to receive local minocycline
microspheres (17 subjects and 57 implants) or chlorhexidine gel (15 subjects and 38
implants) following debridement. Treatments were performed on three occasions:
baseline and days 30 and 90. Follow-up examinations were conducted at 10 days and
at 1, 3, 6, 9, and 12 months. RESULTS: The use of minocycline resulted in
significant improvements in probing depths compared to chlorhexidine at days 30,
90, and 180 (P = 0.5, P = 0.01, and P = 0.04, respectively). For the deepest sites
of the minocycline-treated implants, the mean probing depth reduction was 0.6 mm at
12 months. Regarding bleeding on probing, significant differences between groups,
based on all four sites at the implants, were found at days 30, 90, 180, 270, and
360. Both treatments resulted in a marked reduction in the indicator bacteria.
CONCLUSIONS: The use of a repeated local antibiotic as an adjunct to the mechanical
treatment of peri-implantitis lesions demonstrated improvements in probing depths
that were significantly different from controls and were sustained for 6 months.
The adjunctive use of minocycline microspheres is beneficial in the treatment of
peri-implant lesions, but the treatment may have to be repeated.
AN - rayyan-563561322
AU - Renvert, S.
AU - Lessem, J.
AU - Dahlén, G.
AU - Renvert, H.
AU - Lindahl, C.
CY - United States
DO - 10.1902/jop.2008.070347
ET - 5
J2 - J Periodontol
KW - Adult
Aged
Bacteria/classification/drug effects
Chi-Square Distribution
Chlorhexidine/administration & dosage/*analogs & derivatives
Dental Implantation, Endosseous/adverse effects
Dental Implants/*adverse effects/microbiology
Dental Scaling
Female
Follow-Up Studies
Gels
Humans
Male
Microspheres
Middle Aged
Minocycline/*administration & dosage
Periodontal Index
Periodontitis/*drug therapy/etiology/microbiology
Prosthesis-Related Infections/*drug therapy/microbiology
Retreatment
Single-Blind Method
LA - eng
N1 - Department of Health Sciences, Kristianstad University, Kristianstad, Sweden.
stefan.renvert@hv.hkr.se
PY - 2008
SN - 0022-3492 (Print)
SP - 836-44
system in the treatment of peri-implantitis: a randomized clinical trial
system in the treatment of peri-implantitis: a randomized clinical trial
VL - 79
Y2 - 5
ID - 14696
ER -
TY - JOUR
AB - Background: Peri-implantitis is an inflammatory process caused by
1 mg, in cases of peri-implantitis. Methods: Thirty-two subjects with at least one
implant with a probing depth A mm combined with bleeding and/or exudate on probing
and the presence of putative pathogenic bacteria were included in the study. At
baseline, subjects were randomly assigned to receive local minocycline microspheres
(17 subjects and 57 implants) or chlorhexidine gel (15 subjects and 38 implants)
following debridement. Treatments were performed on three occasions: baseline and
days 30 and 90. Follow-up examinations were conducted at 10 days and at 1, 3, 6, 9,
and 12 months. Results: The use of minocycline resulted in significant improvements
in probing depths compared to chlorhexidine at days 30, 90, and 180 (P = 0.5, P =
0.01, and P = 0.04, respectively). For the deepest sites of the minocycline-treated
implants, the mean probing depth reduction was 0.6 mm at 12 months. Regarding
bleeding on probing, significant differences between groups, based on all four
sites at the implants, were found at days 30, 90, 180, 270, and 360. Both
treatments resulted in a marked reduction in the indicator bacteria. Conclusions:
The use of a repeated local antibiotic as an adjunct to the mechanical treatment of
peri-implantitis lesions demonstrated improvements in probing depths that were
significantly different from controls and were sustained for 6 months. The
adjunctive use of minocycline microspheres is beneficial in the treatment of peri-
implant
AN - rayyan-563562593
AU - Renvert, S.
AU - Lessem, J.
AU - Dahlen, G.
AU - Renvert, H.
AU - Lindahl, C.
DO - 10.1902/jop.2008.070347
IS - 5
PY - 2008
SN - ["0022-3492", "1943-3670"]
SP - 836-844
VL - 79
Y2 - 5
ID - 15967
ER -
TY - JOUR
AB - This report presents the clinical results three months after application of
minocycline microspheres as an adjunct to mechanical treatment of incipient peri-
implant infections compared to adjunctive treatment employing 1% chlorhexidine gel
application. Sixteen patients in the minocycline group and 14 in the chlorhexidine
group completed the study. Each patient had one or more implants with probing depth
> or = 4 mm combined with bleeding and/or exudate on probing and presence of
putative pathogenic bacteria. At baseline, patients were randomly assigned to
minocycline or chlorhexidine treatment. Follow-up examinations were carried out
after 10, 30, 60 and 90 days. The combined mechanical/antimicrobial treatment for
the chlorhexidine group did not result in any reduction in probing depth and only
limited reduction of bleeding scores. The adjunctive use of minocycline
microspheres, on the other hand, resulted in improvements in both probing depths
and bleeding scores. For the deepest sites of the treated implants, mean probing
depth was reduced from 5.0 mm to 4.1 mm. The reductions in bleeding scores,
although greater than for the chlorhexidine group, were modest. Thus, the question
as to what extent the combined mechanical/minocycline treatment could be considered
adequate for the treated lesions remains to be answered. The present short-term
findings, however, encourage further studies with longer observation intervals on
adjunctive use of minocycline microspheres in the treatment of periimplant lesions.
AN - rayyan-563560856
AU - Renvert, S.
AU - Lessem, J.
AU - Lindahl, C.
AU - Svensson, M.
IS - 4
chlorhexidine
microsphere
minocycline
adult
aged
article
clinical trial
comparative study
controlled study
debridement
female
human
male
middle aged
periodontitis
tooth implantation
LA - English
PY - 2004
SN - 1466-2094
SP - 154-159
ST - Treatment of incipient peri-implant infections using topical minocycline
microspheres versus topical chlorhexidine gel as an adjunct to mechanical
debridement
TI - Treatment of incipient peri-implant infections using topical minocycline
microspheres versus topical chlorhexidine gel as an adjunct to mechanical
debridement
VL - 6
ID - 14230
ER -
TY - JOUR
AB - Background/aims: Enterococcus faecalis strains with multiple antibiotic
resistances can cause infections that are difficult to treat. The microbial flora
in treatment-resistant apical periodontitis is dominated by E. faecalis, and is a
potential source of infections at other sites. Material and methods: Sensitivities
to a range of antibiotics were determined for 59 endodontic E. faecalis isolates
from Finland and Lithuania. The DNA sequence of the gene responsible for the
species' intrinsic quinupristin-dalfopristin resistance, lsa, was determined from
two isolates with diminished resistance. Four pairs of isolates from the same root
canal were typed by pulsed-field gel electrophoresis. Results: A high prevalence of
resistance to rifampicin was found, whereas all isolates were susceptible or showed
intermediate susceptibility to penicillin and ampicillin and four isolates were
unusually susceptible to cefotaxime. No vancomycin or high-level gentamicin
resistance was detected. Nine of 59 isolates were susceptible to quinupristin-
dalfopristin. A fully quinupristin-dalfopristin-susceptible isolate also
susceptible to clindamycin produced a truncated Lsa polypeptide, and an isolate
with borderline quinupristin-dalfopristin-susceptibility had mutations proximal to
the predicted ribosomal binding site. Pulsed-field gel electrophoresis showed that
the same root canal could harbor two different strains of E. faecalis during the
course of the same infection. Conclusion: Despite the differing antibiotic usage in
Finland and Lithuania, E. faecalis from endodontic infections in these countries
showed similar susceptibility patterns with levels of resistance considered typical
for the species, and decreased resistance to clindamycin and quinupristin-
dalfopristin as well as lesions in the lsa gene which were similar to those
described in other clinical isolates. © Blackwell Munksgaard, 2006.
AN - rayyan-563560770
AU - Reynaud Af Geijersstam, A. H.
AU - Ellington, M. J.
AU - Warner, M.
AU - Woodford, N.
AU - Haapasalo, M.
DO - 10.1111/j.1399-302X.2006.00271.x
IS - 3
KW - ampicillin
bacterial protein
cefotaxime
chloramphenicol
ciprofloxacin
clindamycin
dalfopristin
dalfopristin plus quinupristin
erythromycin
gentamicin
glycopeptide
lincosamide
linezolid
penicillin G
polypeptide
protein lsa
rifampicin
streptomycin
teicoplanin
tetracycline
unclassified drug
vancomycin
article
bacterial gene
bacterial strain
bacterium isolate
binding site
controlled study
DNA sequence
drug use
endodontics
Finland
genetic susceptibility
Lithuania
microflora
molecular dynamics
nonhuman
nucleotide sequence
periodontitis
ribosome
tooth root canal
treatment failure
LA - English
PY - 2006
SN - ["0902-0055", "1399-302X"]
SP - 164-168
ST - Antimicrobial susceptibility and molecular analysis of Enterococcus faecalis
TI - Antimicrobial susceptibility and molecular analysis of Enterococcus faecalis
VL - 21
ID - 14144
ER -
TY - JOUR
AB - Objective: Chlorhexidine digluconate is widely used in dental practice for
decreasing plaque control, controlling gingivitis and disinfecting root canals.
However, the undesirable effects of chlorhexidine digluconate regarding its gen
otoxicity are conflicting in the literature. Thus, the aim of this study was to
investigate the genotoxicity of chlorhexidine digluconate in rat peripheral blood
and oral mucosal cells by the single cell gel (comet) assay and micronucleus assay.
Methods: Thirty male Wistar rats were distributed into three groups: negative
control; experimental group orally treated with 0.5 ml of 0.12% chlorhexidine
digluconate, twice daily, during 8 days; and positive control, which received 4-
nitroquinoline 1-oxide at 0.5 g/l by drinking water. Results: A statistically
significant increase of DNA damage was observed in leukocytes and oral mucosal
cells of the chlorhexidine digluconate treated group, as assessed by the comet
assay. However, no increase of micronucleated cells was detected in reticulocytes
from peripheral blood cells. Conclusions: Taken together, the data indicate that
chlorhexidine digluconate is able to induce primary DNA damage in leukocytes and in
oral mucosal cells, but no chromosome breakage or loss in erythrocytes. © Blackwell
Munksgaard 2004.
AN - rayyan-563560855
AU - Ribeiro, D. A.
AU - Bazo, A. P.
AU - Da Silva Franchi, C. A.
AU - Esther, M.
AU - Marques, A.
AU - Favero Salvadori, D. M.
DO - 10.1111/j.1600-0765.2004.00759.x
IS - 5
KW - chlorhexidine
drinking water
animal cell
animal tissue
article
blood cell
comet assay
controlled study
data analysis
DNA damage
leukocyte
male
mouth mucosa
multinuclear cell
nonhuman
rat
reticulocyte
LA - English
PY - 2004
SN - 0022-3484
SP - 358-361
ST - Chlorhexidine induces DNA damage in rat peripheral leukocytes and oral
mucosal cells
TI - Chlorhexidine induces DNA damage in rat peripheral leukocytes and oral
mucosal cells
VL - 39
ID - 14229
ER -
TY - JOUR
AB - Oral bacterial infection represents the leading cause of the gradual
destruction of tooth and periodontal structures anchoring the teeth. Lately,
injectable hydrogels have gained increased attention as a promising minimally
invasive platform for localized delivery of personalized therapeutics. Here, an
injectable and photocrosslinkable gelatin methacryloyl (GelMA) hydrogel is
successfully engineered with ciprofloxacin (CIP)-eluting short nanofibers for oral
infection ablation. For this purpose, CIP or its β-cyclodextrin (β-CD)-inclusion
complex (CIP/β-CD-IC) has been incorporated into polymeric electrospun fibers,
which were subsequently cut into short nanofibers, and then embedded in GelMA to
obtain an injectable hybrid antimicrobial hydrogel. Thanks to the solubility
enhancement of CIP by β-CD-IC and the tunable degradation profile of GelMA, the
hydrogels promote localized, sustained, and yet effective cell-friendly antibiotic
doses, as measured by a series of bacterial assays that demonstrated efficacy in
attenuating the growth of Gram-positive Enterococcus faecalis. Altogether, we
foresee significant potential in translating this innovative hybrid hydrogel as an
injectable platform technology that may have broad applications in oral infection
ablation, such as periodontal disease and pulpal pathology.
AN - rayyan-563560091
AU - Ribeiro, J. S.
AU - Daghrery, A.
AU - Dubey, N.
AU - Li, C.
AU - Mei, L.
AU - Fenno, J. C.
AU - Schwendeman, A.
AU - Aytac, Z.
AU - Bottino, M. C.
DO - 10.1021/acs.biomac.0c01131
IS - 9
beta cyclodextrin
ciprofloxacin
gelatin
hydrogel
nanofiber
article
bacterial growth
bacterial infection
controlled study
degradation
drug solubility
electrospinning
human
human cell
mouth infection
nonhuman
polymerization
priority journal
LA - English
PY - 2020
SN - ["1526-4602", "1525-7797"]
SP - 3945-3956
ST - Hybrid Antimicrobial Hydrogel as Injectable Therapeutics for Oral Infection
Ablation
T2 - Biomacromolecules
TI - Hybrid Antimicrobial Hydrogel as Injectable Therapeutics for Oral Infection
Ablation
VL - 21
ID - 13465
ER -
TY - JOUR
AB - DATA SOURCES: Medline, Embase and the Cochrane Central Register of Controlled
Trials (CENTRAL). STUDY SELECTION: Randomized controlled trials (RCTs) or
controlled clinical trials (CCTs) in adults 18 years of age comparing CHX DF/gel
with CHX MW written in English or Dutch were considered. DATA EXTRACTION AND
SYNTHESIS: Two reviewers independently selected studies, abstracted data and
assessed risk of bias. Where possible, a meta-analysis was performed. Difference in
means values between test and control at both baseline and end was calculated using
a fixed-effects model. RESULTS: Five RCTs were included, four had a parallel design
and one was a cross-over trial. Three studies showed a positive score in favour of
the mouthwash. Three studies contributed to a meta-analysis of the effect on 'de
novo' plaque formation. There was a difference in means of 0.27 [95% CI: 0.14;
0.39] (P < 0.0001) in favour of CHX MW. One study assessed tooth staining finding
more staining with the use of CHX MW compared to the CHX DF/gel. CONCLUSIONS:
Chlorhexidine gel can be successfully formulated and will inhibit plaque growth to
some degree, but not to the same extent, as a CHX MW. When CHX DF/gel is used in a
non-brushing model, it is significantly less effective in plaque inhibition
compared to CHX MW. Based on one study when CHX gel was applied with a finger after
brushing, it is significantly more effective on plaque scores and the gingival
index. The only brushing study also with a long follow-up showed that there is no
significant difference between CHX DF and CHX MW. However, as a corollary,
significantly more tooth discoloration was observed with the CHX MW. Altogether,
the data show that when daily oral hygiene cannot be performed, CHX MW is the first
product of choice.
AN - rayyan-563560382
AU - Richards, D.
DO - 10.1038/sj.ebd.6401102
IS - 2
KW - chlorhexidine
mouthwash
toothpaste
chemically induced
tooth plaque
gingiva bleeding
gingivitis
human
tooth discoloration
LA - English
PY - 2015
SN - 1476-5446
SP - 59
ST - Chlorhexidine mouthwash more effective than dentifrice or gel
T2 - Evid Based Dent
TI - Chlorhexidine mouthwash more effective than dentifrice or gel
VL - 16
ID - 13756
ER -
TY - JOUR
AB - Objective: The treatment of periodontitis with scaling and root planing has a
good prognosis. However, periodontitis may also exacerbate. The mucoadhesive patch
is one of the distribution systems of topical drugs, which is not irritable to the
mucosa and eventually increases permeability. Based on phytochemical screening,
mangosteen peel extract has an active ingredient with high anti-inflammatory and
antibacterial properties. This study aims to understand the potential of a
mucoadhesive patch loaded with mangosteen peel extract to inhibit alveolar bone
damage in periodontitis. Methods: This experimental laboratory research was
conducted using 27 Wistar rats divided into three groups: the positive control
group (0.7% tetracycline gel application), negative control group (mucoadhesive
patch application), and experimental group (mucoadhesive patch loaded with
mangosteen peel extract application). Rats were administered 1 × 109 colony-forming
unit as much as 200 μL of Actinobacillus actinomycetemcomitans bacteria three times
at 2-day intervals. Tetracycline gel and mucoadhesive patch application were
administered for 1 h/day for 3 days. Three rats from each group were sacrificed on
days 3, 5, and 7 after the application. The lower jaw was dissected for
histopathological examination using haematoxylin and eosin staining to determine
the number of osteoclasts and osteoblasts. Results: The mucoadhesive patches loaded
with mangosteen peel extract significantly reduced the number of osteoclasts and
increased the number of osteoblasts in all groups (p < 0.05). Conclusion: The
mucoadhesive patches loaded with mangosteen peel extract can prevent alveolar bone
damage in periodontitis by inhibiting the number of osteoclasts and increasing the
number of osteoblasts.
AN - rayyan-563559932
AU - Ridwan, R. D.
AU - Yuliati, Y.
AU - Sidarningsih, S.
AU - Sholihah, F. M.
AU - Aljunaid, M.
AU - Lashari, D. M.
DO - 10.1016/j.jtumed.2021.06.011
IS - 6
eosin
gel
hematoxylin
ketamine
mangosteen peel extract
plant extract
tetracycline
unclassified drug
alveolar bone loss
animal cell
animal experiment
animal model
article
bone injury
colony forming unit
controlled study
experimental study
fruit
fruit peel
histopathology
male
mandible
mangosteen
nonhuman
osteoblast
osteoclast
periodontitis
rat
staining
Wistar rat
LA - English
PY - 2021
SN - 1658-3612
SP - 864-869
ST - A study of the mucoadhesive patches loaded with mangosteen peel extract in
periodontitis
T2 - J. Taibah. Univ. Med. Sci.
TI - A study of the mucoadhesive patches loaded with mangosteen peel extract in
periodontitis
VL - 16
ID - 13306
ER -
TY - JOUR
AB - The purpose of this investigation was to evaluate the effect of local
antibiotic therapy with metronidazole adjunctively to scaling and root planing
(SRP) versus mechanical treatment alone. 30 maintenance-patients were included in
this single-blind study. The subjects had to comply with the following criteria: 2
non-adjacent sites with a probing depth > or =6 mm with bleeding on probing in
separate quadrants, no periodontal therapy within the last 3 months, and no
antibiotic therapy within the last 6 months. After randomization, the study sites
were assigned to one of the following 2 treatments: SRP plus subgingival
application of metronidazole 25% dental gel (Elyzol) 5x during 10 days (test site)
or SRP alone (control site). Subgingival microbiological samples were taken prior
to, and 21 days and 3 months after scaling. The samples were analyzed with a
commercial chair-side ELISA (Evalusite) for Porphyromonas gingivalis, Prevotella
intermedia and Actinobacillus actinomycetemcomitans. Probing pocket depth (PPD),
attachment level (AL) and bleeding on probing (BOP) were recorded at baseline and 3
months later. PPD reduction and AL-gain were statistically significant (p<0.001)
after both treatments. However, there were no statistically significant differences
between them. The same observation was made for BOP. P. gingivalis was reduced
significantly after both treatments without statistically significant differences.
P. intermedia was reduced significantly only after SRP. A. actinomycetemcomitans
was not reduced significantly after either treatment. In conclusion, the repeated
local application of metronidazole as an adjunct to SRP and the mechanical
treatment alone showed similar clinical and microbiological effects without
statistically significant differences with the exception of P. intermedia.
AN - rayyan-563561002
AU - Riep, B.
AU - Purucker, P.
AU - Bernimoulin, J. P.
IS - 11
metronidazole
article
bacterial count
clinical trial
comparative study
controlled study
drug effect
female
follow up
gel
gingiva bleeding
human
male
microbiology
middle aged
periodontal disease
periodontitis
recurrent disease
LA - English
PY - 1999
SN - 0303-6979
SP - 710-715
ST - Repeated local metronidazole-therapy as adjunct to scaling and root planing
in maintenance patients
TI - Repeated local metronidazole-therapy as adjunct to scaling and root planing
in maintenance patients
VL - 26
ID - 14376
ER -
TY - JOUR
AB - Objective: Periodontitis and diabetes are related and high blood glucose
level plays an important part in this correlation. Corn silk has the property of
anti-hyperglycemic and anti-inflammation. The aim of this study was to determine
the capability of corn silk based Ethosomal gel to reduce blood glucose level and
degree of inflammation in alloxan induced rats. Material and Method: 15 wistar male
rats with initial weight of 150gram were included in this study. Alloxan was used
to induce diabetes and 5-0 silk ligatures to induce periodontitis. Blood glucose
level was analyzed before and after induction, 3 days after administration, and 7
days after. Degree of inflammation was examined with histopathology test. Results:
Blood glucose level in F1 is unstable (p=0.0583>p=0.05), whilst F2 and F3 both
showed stable blood glucose decrease (F2: p=0.0086<p=0.05; F3: p=0.035<p=0.05).
Anti-inflammation effects best shown in F3, which has mild inflammation
(p=0.001<p=0.05).Whereas both F1 and F2 have moderate inflammation (F1:
p=0.225>p=0.05; F2: p=0.423>p=0.05). Conclusion: Corn silk based Ethosomal gel
treatment manage to reduce blood glucose level and periodontitis in alloxan induced
diabetic rats.
AN - rayyan-563560177
AU - Riewpassa, I. E.
AU - Kim, Y. R.
AU - Tenrilili, A. N. A.
AU - Untung, J. S.
AU - Djamaludin, N. S.
AU - Achmad, H.
DO - 10.5958/0976-5506.2019.02554.3
IS - 9
KW - alloxan
carbomer
Carbomer 940
corn silk extract
glycerol
methyl paraben
phosphatidylcholine
plant extract
propylene glycol
silk
triethanolamine
unclassified drug
animal experiment
animal tissue
article
controlled study
diabetes mellitus
ethosomal gel
glucose blood level
histopathology
hyperglycemia
inflammation
male
nonhuman
periodontitis
phospholipid vesicle
rat
LA - English
PY - 2019
SN - ["0976-5506", "0976-0245"]
SP - 907-913
ST - Corn silk based ethosomal gel: A new treatment for periodontitis in diabetic
albino rats a prelimenary study
TI - Corn silk based ethosomal gel: A new treatment for periodontitis in diabetic
albino rats a prelimenary study
VL - 10
ID - 13551
ER -
TY - JOUR
AB - Objective. Chronic T cell activation is central to the etiology of rheumatoid
arthritis (RA), an inflammatory autoimmune disease that leads to severe focal bone
erosions and generalized systemic osteoporosis. Previous studies have shown novel
cytokine-like activities in medium containing activated T cells, characterized by
potent induction of the osteoblastic production of interleukin-6 (IL-6), an
inflammatory cytokine and stimulator of osteoclastogenesis, as well as induction of
an activity that directly stimulates osteoclast formation in a manner independent
of the key osteoclastogenic cytokine RANKL. This study was undertaken to identify
the factors secreted by T cells that are responsible for these activities. Methods.
Human T cells were activated using anti-human CD3 and anti-human CD28 antibodies
for 72 hours in AIM V serum-free medium to obtain T cell-conditioned medium,
followed by concentration and fractionation of the medium by fast-protein liquid
chromatography. Biologically active fractions were resolved using sodium dodecyl
sulfate-polyacrylamide gel electrophoresis. Major bands were analyzed by mass
spectrometry, and a major candidate protein was identified. This novel cytokine was
cloned, and its expression was analyzed using recombinant DNA technologies.
Results. A single novel cytokine that could induce both osteoblastic IL-6
production and functional osteoclast formation in the absence of osteoblasts or
RANKL and that was insensitive to the effects of the RANKL inhibitor
osteoprotegerin was identified in the activated T cell-conditioned medium; this
cytokine was designated secreted osteoclastogenic factor of activated T cells
(SOFAT). Further analysis of SOFAT revealed that it was derived from an unusual
messenger RNA splice variant coded by the threonine synthase-like 2 gene homolog,
which is a conserved gene remnant coding for threonine synthase, an enzyme that
functions only in microorganisms and plants. Conclusion. SOFAT may act to
exacerbate inflammation and/or bone turnover under inflammatory conditions such as
RA or periodontitis and in conditions of estrogen deficiency. © 2009, American
College of Rheumatology.
AN - rayyan-563560659
AU - Rifas, L.
AU - Weitzmann, M. N.
DO - 10.1002/art.24877
IS - 11
KW - CD3 antibody
cytokine
interleukin 6
messenger RNA
monoclonal antibody CD28
protein sofat
recombinant DNA
synthetase
thnsl2 enzyme
threonine
unclassified drug
article
controlled study
gene expression
gene structure
genetic conservation
genetic variability
human
human cell
mass spectrometry
molecular cloning
osteoblast
osteoclast
priority journal
protein analysis
RNA splicing
sequence homology
LA - English
PY - 2009
SN - ["0004-3591", "1529-0131"]
SP - 3324-3335
ST - A novel T cell cytokine, secreted osteoclastogenic factor of activated T
cells, induces osteoclast formation in a RANKL-independent manner
T2 - Arthritis Rheum.
TI - A novel T cell cytokine, secreted osteoclastogenic factor of activated T
cells, induces osteoclast formation in a RANKL-independent manner
VL - 60
ID - 14033
ER -
TY - JOUR
AB - The antimicrobial activity of lingonberry (Vaccinium vitis-idaea L.) was
evaluated against two oral pathogens, Streptococcus mutans and Fusobacterium
nucleatum. Long-bed gel permeation chromatography (GPC; Sephadex LH-20) yielded
purified flavonoids, with the most efficient minimum inhibitory concentrations
(MICs) against planktonic cells in the anthocyanin and procyanidin primary
fractions against F. nucleatum (63-125 μg/ml) and in the procyanidin rich fraction
against S. mutans (16-31 μg/ml). The purified flavonol glycosides and procyanidins
inhibited biofilm formation of S. mutans (MICs 16-31 μg/ml), while the
corresponding reference compounds showed no activity. Secondary GPC purification
yielded flavonol glycosides devoid of antibiofilm activity in the 50% MeOH
fraction, while elution with 70% acetone recovered a brownish material with
activity against S. mutans biofilm (MIC 8 μg/ml). Even after HPLC-PDA, NMR, and
MALDI-TOF analyses, the structural identity of this material remained unknown,
while its color and analytical characteristics appear to be consistent with
flavonoid oxidation products. © 2014 Elsevier B.V.
AN - rayyan-563560440
AU - Riihinen, K. R.
AU - Ou, Z. M.
AU - Gödecke, T.
AU - Lankin, D. C.
AU - Pauli, G. F.
AU - Wu, C. D.
DO - 10.1016/j.fitote.2014.05.012
KW - anthocyanin
glycoside
procyanidin
article
biofilm
dental caries
drug purification
lingonberry
periodontal disease
priority journal
LA - English
PY - 2014
SN - ["1873-6971", "0367-326X"]
SP - 78-86
ST - The antibiofilm activity of lingonberry flavonoids against oral pathogens is
a case connected to residual complexity
T2 - Fitoterapia
TI - The antibiofilm activity of lingonberry flavonoids against oral pathogens is
a case connected to residual complexity
VL - 97
ID - 13814
ER -
TY - JOUR
AB - Periodontitis is a multifactorial polymicrobial infection characterized by a
destructive inflammatory process affecting tooth-supporting tissues and resulting
in periodontal pocket formation, alveolar bone resorption and, eventually, tooth
loss. The continuous challenge of host immune and resident cells by
periodontopathogens and their virulence factors, such as lipopolysaccharide (LPS),
results in enhanced and uncontrolled secretion of cytokines. The latter directly or
indirectly participate in tissue destruction and bone resorption. Metronidazole
(MTZ) is a widely used antimicrobial agent. The immunomodulatory effects of
antibiotics might influence the degree of the local response to infection on the
human periodontal ligament cell (HPLC). HPLCs play a role in the immune response of
the oral cavity. In addition, HPLC can produce cytokines that increase the
inflammatory response and that supply for normal communication. MTZ has also been
proposed in the field of periodontal therapy either with a systemic administration
or with local biodegradable sustained-release agents. The local administration of
MTZ in the form of gel significantly reduces the systemic side effects. The aim of
the present study, was to simulate the in vivo conditions occurring in diseased
periodontal sites, and to evaluate the effects of MTZ on the viability of isolated
HPLCs. The ability of MTZ to modulate the release of interleukin (IL)-1β, IL-6, IL-
8, IL-12 and tumor necrosis factor alpha (TNF-α) in HPLC, treated or not with LPS
of Porphyromonas gingivalis was also evaluated. The results obtained showed that
MTZ had no cytotoxic effect on HPLC and was able to inhibit the production of pro-
inflammatory cytokines analyzed. The ability of MTZ to determine immunomodulatory
effects could provide possible therapeutic applications in the field of periodontal
research. © 2010 Elsevier B.V. All rights reserved.
AN - rayyan-563560637
AU - Rizzo, A.
AU - Paolillo, R.
AU - Guida, L.
AU - Annunziata, M.
AU - Bevilacqua, N.
AU - Tufano, M. A.
DO - 10.1016/j.intimp.2010.04.004
IS - 7
KW - bacterium lipopolysaccharide
interleukin 12
interleukin 1beta
interleukin 6
interleukin 8
messenger RNA
metronidazole
metronidazolo
unclassified drug
article
cell viability
controlled study
cytokine production
cytotoxicity test
drug effect
gene expression
human
human cell
immunomodulation
priority journal
LA - English
PY - 2010
SN - 1567-5769
SP - 744-750
ST - Effect of metronidazole and modulation of cytokine production on human
periodontal ligament cells
T2 - Int. Immunopharmacol.
TI - Effect of metronidazole and modulation of cytokine production on human
periodontal ligament cells
VL - 10
ID - 14011
ER -
TY - JOUR
AB - The ability for DNA mismatch repair, after oxidative stress-induced DNA
damage, is critical for the persistence of Porphyromonas gingivalis in the
inflammatory environment of the periodontal pocket. Our previous report
demonstrated that, in contrast to other organisms, the repair of oxidative stress-
induced DNA damage involving 8-oxo-7,8-dihydroguanine (8-oxoG) may occur by a yet-
to-be described mechanism in P. gingivalis. 8-oxoG does not block DNA replication;
rather, it mispairs with adenine, which can be repaired by the MutY glycosylase. To
determine the function of the P. gingivalis MutY homologue in DNA repair, it was
insertionally inactivated using the ermF-ermAM antibiotic cassette and used to
create a mutY-deficient mutant (FLL147) by allelic exchange mutagenesis. FLL147 had
an increased rate of spontaneous mutation and was more sensitive to hydrogen
peroxide compared with the wild-type W83 strain. DNA oligomers containing a site-
specific 8-oxoG:A mispair was repaired similarly in both the P. gingivalis mutY-
defective mutant and wild-type strains. The P. gingivalis mutY homologue was shown
to complement the mutY mutation in Escherichia coli. In a gel mobility shift assay,
the purified recombinant MutY is able to bind an oligo containing an 8-oxoG:A
mispair. Taken together, MutY may play the expected role in oxidative stress
resistance in P. gingivalis. However, there may exist other redundant mechanism(s)
for the removal of 8-oxoG:A mismatch in this organism. © 2011 John Wiley & Sons
A/S.
AN - rayyan-563560588
AU - Robles, A. G.
AU - Reid, K.
AU - Roy, F.
AU - Fletcher, H. M.
DO - 10.1111/j.2041-1014.2011.00605.x
IS - 3
KW - 8 hydroxyguanine
adenine
cell extract
DNA glycosylase MutY
oligomer
oligonucleotide
rifampicin
amino acid sequence
article
bacterial strain
bacterium
bacterium culture
base mispairing
bioinformatics
controlled study
DNA damage
DNA determination
DNA isolation
DNA purification
DNA repair
DNA replication
DNA sequence
Escherichia coli
gel electrophoresis
gene inactivation
gene insertion
gene mutation
gene sequence
mutagenesis
mutagenicity
nonhuman
oxidative stress
plasmid
protein DNA interaction
LA - English
PY - 2011
SN - ["2041-1006", "2041-1014"]
SP - 175-186
ST - Porphyromonas gingivalis mutY is involved in the repair of oxidative stress-
induced DNA mispairing
TI - Porphyromonas gingivalis mutY is involved in the repair of oxidative stress-
induced DNA mispairing
VL - 26
ID - 13962
ER -
TY - JOUR
AB - Angiogenesis is generally a quiescent process which, however, may be modified
by different physiological and pathological conditions. The "angiogenic paradox"
has been described in diabetes because this disease impairs the angiogenic response
in a manner that differs depending on the organs involved and disease evolution.
Aging is also associated with pro- and antiangiogenic processes. Glycation, the
post-translational modification of proteins, increases with aging and the
progression of diabetes. The effect of glycation on angiogenesis depends on the
type of glycated proteins and cells involved. This complex link could be
responsible for the "angiogenic paradox" in aging and age-related disorders and
diseases. Using diabetes as a model, the present work has attempted to review the
age-related angiogenic paradox, in particular the effects of glycation on
angiogenesis during aging. © 2014 Elsevier B.V.
AN - rayyan-563560437
AU - Roca, F.
AU - Grossin, N.
AU - Chassagne, P.
AU - Puisieux, F.
AU - Boulanger, E.
DO - 10.1016/j.arr.2014.03.009
IS - 1
KW - advanced glycation end product
aldehyde reductase
cancer growth factor
collagen gel
glucose
glycosylated protein
iditol dehydrogenase
interleukin 1beta
interleukin 2
interleukin 6
neurotoxin
nicotinamide adenine dinucleotide phosphate
pattern recognition receptor
scavenger receptor
somatomedin
tumor growth factor beta
tyrosine kinase receptor
unclassified drug
vasculotropin
vasculotropin 121
vasculotropin 165
vasculotropin receptor 2
aerobic metabolism
aging
Alzheimer disease
angiogenesis
aortic valve disease
apoptosis
arterial stiffness
arterial wall thickness
astrocyte
atherosclerosis
basement membrane
blood brain barrier
blood clotting
blood vessel permeability
brain cortex
capillary density
cell damage
cell proliferation
chorioallantois
collateral circulation
cutaneous parameters
diabetes mellitus
diabetic nephropathy
diabetic retinopathy
disease course
encephalitis
endothelial dysfunction
endothelium cell
environmental exposure
epithelization
gene expression
geriatric disorder
glomerulosclerosis
glycation
heart infarction
hippocampus
human
hypoxia
inflammation
ischemia
kidney
laboratory
limb ischemia
lymphocyte
macrophage
mesenchyme cell
mesothelium cell
microglia
mitral valve disease
monocyte
neovascularization (pathology)
neurologic disease
nonhuman
oxidative stress
Parkinson disease
pericyte
phenotype
photoaging
photoreceptor
podocyte
protein processing
age related macular degeneration
retina neovascularization
review
shear stress
signal transduction
smooth muscle cell
substantia nigra pars compacta
tight junction
upregulation
vascular ring
vascular smooth muscle
white matter
wound healing
wound healing impairment
LA - English
PY - 2014
SN - ["1872-9649", "1568-1637"]
SP - 146-160
ST - Glycation: The angiogenic paradox in aging and age-related disorders and
diseases
T2 - Ageing Res. Rev.
TI - Glycation: The angiogenic paradox in aging and age-related disorders and
diseases
VL - 15
ID - 13811
ER -
TY - JOUR
AB - Objectives: The aim of this prospective study was to evaluate a regenerative
surgical treatment modality for peri-implantitis lesions on two different implant
surfaces. Materials and Methods: Twenty-six patients with one crater-like defect,
around either TPS (Control) or SLA (Test) dental implants, with a probing depth
(PD) 6 mm and no implant mobility, were included. The implant surface was
mechanically debrided and treated using a 24% EDTA gel and a 1% chlorhexidine gel.
The bone defect was filled with a bovine-derived xenograft (BDX) and the flap was
sutured around the non-submerged implant. Results: One-year follow-up demonstrated
clinical and radiographic improvements. PDs were significantly reduced by 2.1±1.2
mm in the Control implants and by 3.4±1.7 mm in the Test implants. Complete defect
fill was never found around Controls, while it occurred in three out of 12 Test
implants. Bleeding on probing decreased from 91.1±12.4% (Control) and 75.0±30.2%
(Test) to 57.1±38.5% (p=0.004) and 14.6±16.7% (p=0.003), respectively. Several deep
pockets (≥6 mm) were still present after surgical therapy around Controls.
Conclusions: Surface characteristics may have an impact on the clinical outcome
following surgical debridement, disinfection of the contaminated surfaces and
grafting with BDX. Complete fill of the bony defect seems not to be a predictable
result. © 2011 John Wiley & Sons A/S.
AN - rayyan-563560580
AU - Roccuzzo, M.
AU - Bonino, F.
AU - Bonino, L.
AU - Dalmasso, P.
DO - 10.1111/j.1600-051X.2011.01742.x
IS - 8
KW - Bio Oss
Bio-Oss
biomaterial
chlorhexidine
edetic acid
mineral
titanium
aged
animal
bone matrix
bovine
chemistry
classification
comparative study
dental acid etching
dental etching
female
follow up
gingiva bleeding
human
male
methodology
middle aged
periimplantitis
periodontal pocket
periodontics
plasma gas
prospective study
review
surface property
tooth implantation
tooth prosthesis
transplantation
treatment outcome
xenograft
LA - English
PY - 2011
SN - ["0303-6979", "1600-051X"]
SP - 738-745
ST - Surgical therapy of peri-implantitis lesions by means of a bovine-derived
xenograft: Comparative results of a prospective study on two different implant
surfaces
TI - Surgical therapy of peri-implantitis lesions by means of a bovine-derived
xenograft: Comparative results of a prospective study on two different implant
surfaces
VL - 38
ID - 13954
ER -
TY - JOUR
AB - Sphingolipids (SLs) are essential structural components of mammalian cell
membranes. Our group recently determined that the oral anaerobe Porphyromonas
gingivalis delivers its SLs to host cells and that the ability of P. gingivalis to
synthesize SLs limits the elicited host inflammatory response during cellular
infection. As P. gingivalis robustly produces outer membrane vesicles (OMVs), we
hypothesized that OMVs serve as a delivery vehicle for SLs, that the SL status of
the OMVs may impact cargo loading to OMVs, and that SL-containing OMVs limit
elicited host inflammation similar to that observed by direct bacterial challenge.
Transwell cell culture experiments determined that in comparison to the parent
strain W83, the SL-null mutant elicited a hyper-inflammatory immune response from
THP-1 macrophage-like cells with elevated tumor necrosis factor alpha (TNF-a),
interleukin 1b (IL-1b), and IL-6. Targeted assessment of Toll-like receptors (TLRs)
identified elevated expression of TLR2, unchanged TLR4, and elevated expression of
the adaptor molecules MyD88 and TRIF (Toll/IL-1 receptor domain-containing adaptor-
inducing beta interferon) by SL-null P. gingivalis. No significant differences in
gingipain activity were observed in our infection models, and both strains produced
OMVs of similar sizes. Using comparative two-dimensional gel electrophoresis, we
identified differences in the protein cargo of the OMVs between parent and SL-null
strain. Importantly, use of purified OMVs recapitulated the cellular inflammatory
response observed in the transwell system with whole bacteria. These findings
provide new insights into the role of SLs in P. gingivalis OMV cargo assembly and
expand our understanding of SL-OMVs as bacterial structures that modulate the host
inflammatory response.
AN - rayyan-563560004
AU - Rocha, F. G.
AU - Ottenberg, G.
AU - Eure, Z. G.
AU - Davey, M. E.
AU - Gibson, F. C.
DO - 10.1128/IAI.00614-20
IS - 4
KW - gingipain cysteine endopeptidase
interleukin 1beta
interleukin 6
sphingolipid
toll like receptor
toll like receptor adaptor molecule 1
article
bacterial structures
cell culture
controlled study
host cell
human
human cell
immune response
macrophage
nonhuman
outer membrane
priority journal
protein content
synthesis
LA - English
PY - 2021
SN - ["1098-5522", "0019-9567"]
ST - Sphingolipid-containing outer membrane vesicles serve as a delivery vehicle
to limit macrophage immune response to Porphyromonas gingivalis
T2 - Infect. Immun.
TI - Sphingolipid-containing outer membrane vesicles serve as a delivery vehicle
to limit macrophage immune response to Porphyromonas gingivalis
VL - 89
ID - 13378
ER -
TY - JOUR
AN - rayyan-563561927
AU - Rodanant, P.
AU - Surarit, R.
AU - Laphookhieo, S.
AU - Kuvatanasuchati, J.
IS - 1
PY - 2015
SP - 43-48
ST - In vitro evaluation of the antibacterial and Anti-Inflammation activities of
clausena lansium (Lour.) skeels
T2 - Songklanakarin Journal of Science and Technology
TI - In vitro evaluation of the antibacterial and Anti-Inflammation activities of
clausena lansium (Lour.) skeels
84923672971&partnerID=40&md5=eed49b90c1c4df65d812eebf6ef12efa
VL - 37
ID - 15301
ER -
TY - JOUR
AB - In the course of examination and treatment of 250 patients studied the effect
of medical sorbent, sylard-gel, and aethony immobilized on it upon inflammatory
periodontal diseases. The results of the microbiological examination shaved good
sorption and inhibitory characteristics of immobilized aethony. The best clinical
results were achieved in the treatment chronic generalized gingivitis and chronic
generalized periodontitis.
AN - rayyan-563560917
AU - Rogovaia, E. P.
AU - Garazha, N. N.
IS - 6
KW - etonium
adult
article
chronic disease
drug dosage form
gingivitis
human
microbiology
middle aged
pathology
periodontitis
treatment outcome
LA - Russian
PY - 2001
SN - 0039-1735
SP - 18-21
ST - Clinical and microbiological efficiency of silard gel-immobilized ethonium in
the treatment of periodontal inflammations
T2 - Kliniko-mikrobiologicheskaia éffektivnost' immobilizovannogo na silard-gele
étoniia v lechenii vospalitel'nykh zabolevanii parodonta.
TI - Clinical and microbiological efficiency of silard gel-immobilized ethonium in
the treatment of periodontal inflammations
VL - 80
ID - 14291
ER -
TY - JOUR
AB - Periodontal disease is a multifactorial, bacterially induced inflammatory
condition characterized by the progressive destruction of periodontal tissues. The
successful nonsurgical treatment of periodontitis requires multifunctional
technologies offering antibacterial therapies and promotion of bone regeneration
simultaneously. For the first time, in this study, an injectable piezoelectric
hydrogel (PiezoGEL) was developed after combining gelatin methacryloyl (GelMA) with
biocompatible piezoelectric fillers of barium titanate (BTO) that produce
electrical charges when stimulated by biomechanical vibrations (e.g., mastication,
movements). We harnessed the benefits of hydrogels (injectable, light curable,
conforms to pocket spaces, biocompatible) with the bioactive effects of
piezoelectric charges. A thorough biomaterial characterization confirmed
piezoelectric fillers' successful integration with the hydrogel,
photopolymerizability, injectability for clinical use, and electrical charge
generation to enable bioactive effects (antibacterial and bone tissue
regeneration). PiezoGEL showed significant reductions in pathogenic biofilm biomass
(∼41%), metabolic activity (∼75%), and the number of viable cells (∼2-3 log)
compared to hydrogels without BTO fillers in vitro. Molecular analysis related the
antibacterial effects to be associated with reduced cell adhesion (downregulation
of porP and fimA) and increased oxidative stress (upregulation of oxyR) genes.
Moreover, PiezoGEL significantly enhanced bone marrow stem cell (BMSC) viability
and osteogenic differentiation by upregulating RUNX2, COL1A1, and ALP. In vivo,
PiezoGEL effectively reduced periodontal inflammation and increased bone tissue
regeneration compared to control groups in a mice model. Findings from this study
suggest PiezoGEL to be a promising and novel therapeutic candidate for the
treatment of periodontal disease nonsurgically.
AN - rayyan-563561391
AU - Roldan, L.
AU - Montoya, C.
AU - Solanki, V.
AU - Cai, K. Q.
AU - Yang, M.
AU - Correa, S.
AU - Orrego, S.
DO - 10.1021/acsami.3c08336
J2 - ACS Appl Mater Interfaces
LA - eng
N1 - Department of Oral Health Sciences, Kornberg School of Dentistry, Temple
University, Philadelphia, Pennsylvania 19140, United States.; Bioengineering
Research Group (GIB), Universidad EAFIT, Medellín 050037, Colombia.; Department of
Oral Health Sciences, Kornberg School of Dentistry, Temple University,
Philadelphia, Pennsylvania 19140, United States.; Department of Oral Health
Sciences, Kornberg School of Dentistry, Temple University, Philadelphia,
Pennsylvania 19140, United States.; Histopathology Facility, Fox Chase Cancer,
Temple University, Philadelphia, Pennsylvania 19140, United States.; Department of
Oral Health Sciences, Kornberg School of Dentistry, Temple University,
Philadelphia, Pennsylvania 19140, United States.; Department of Endodontology,
Kornberg School of Dentistry, Temple University, Philadelphia, Pennsylvania 19140,
United States.; Bioengineering Research Group (GIB), Universidad EAFIT, Medellín
050037, Colombia.; Department of Oral Health Sciences, Kornberg School of
Dentistry, Temple University, Philadelphia, Pennsylvania 19140, United States.;
Bioengineering Department, College of Engineering, Temple University. Philadelphia,
Pennsylvania 19122, United States.
PY - 2023
ST - A Novel Injectable Piezoelectric Hydrogel for Periodontal Disease Treatment
T2 - ACS applied materials & interfaces
TI - A Novel Injectable Piezoelectric Hydrogel for Periodontal Disease Treatment
Y2 - 9 y3 - 6
ID - 14765
ER -
TY - JOUR
AB - AIM: The aim of this study was to assess if the probing pocket depth is a
reliable clinical parameter in the evaluation of the depth of the peri-implant
sulci. In case of chronic inflamed peri-implant tissues, this evaluation is useful
for understanding the level of bone resorption. METHODS: The study enrolled 22
patients. All of them were diagnosed for a peri-implantitis and were scheduled for
a resective surgery with implantoplasty. During the surgery, a full thickness flap
was raised and resective surgery was performed as well as an implantoplasty
procedure. Peri-implant probing values before the surgery (PAL) were recorded, as
were values of bone resorption after flap elevation (DIB), at all four sites around
each implant (88 sites). RESULTS: The mean value of PAL calculated for all 88 sites
was 5.67 mm (+/-1.46); the correspondent value of DIB was 6.37 mm (+/-1.81). In 52
sites out of 88 (59.1%) the values of PAL and DIB were exactly the same (maximum
difference 0.5 mm). In only 10 cases (11.3%) the difference between PAL and DIB was
>2 mm. The mean values for PAL and DIB were not statistically different.
CONCLUSIONS: Authors have concluded that in case of chronic inflammation of peri-
implant tissues, the probe reaches the bone pick, allowing the clinician to have
reliable information on the actual bone resorption.
AN - rayyan-563560683
AU - Romeo, E.
AU - Lops, D.
AU - Storelli, S.
AU - Ghisolfi, M.
IS - 3
metronidazole
tetracycline
article
debridement
device removal
evaluation study
gel
gingiva bleeding
human
devices
methodology
osteolysis
periodontics
periodontitis
tooth implantation
validation study
LA - ["English", "Italian"]
PY - 2009
SN - 0026-4970
SP - 81-91
ST - Clinical peri-implant sounding accuracy in the presence of chronic
inflammation of peri-implant tissues. Clinical observation study
TI - Clinical peri-implant sounding accuracy in the presence of chronic
inflammation of peri-implant tissues. Clinical observation study
VL - 58
ID - 14057
ER -
TY - JOUR
AB - As the American Academy of Periodontology indicates, the treatment of chronic
periodontitis should be achieved in the least invasive manner through non-surgical
periodontal therapy. However, complete removal of subgingival plaque and calculus
is hindered with increasing probing depth (PD) and furcation involvement using
hand, sonic or ultrasonic instruments. Many authors have suggested that the use of
laser as an adjunct to scaling and root planing (SRP) might improve the
effectiveness of conventional periodontal treatment. The aim of this study was to
evaluate potassium-titanyl-phosphate (KTP) laser in non-surgical periodontal
therapy. Seven hundred and thirty sites with probing depths of 4-6 mm were involved
in the study. The sites were divided into four groups: control (SRP, chlorhexidine
gel 0.5%), group A (SRP, chlorhexidine gel 0.5%, three sessions of KTP laser
irradiation); group B (SRP, three sessions of KTP laser irradiation) and group C
(SRP, irrigation with povidone-iodine 10%, three sessions of KTP laser
irradiation). KTP laser was used with the following parameters: output power 0.6 W,
time on 10 ms, time off 50 ms, 30 s per irradiation, fluence 19 J/cm2. All the
sites showed improvement in all clinical parameters. Clinical attachment loss
(CAL), pocket probing depths (PPDs) and bleeding on probing (BOP), especially in
the lased groups, showed significant results (P < 0.001). Our experience showed KTP
laser to be a significant help in SRP; nevertheless, more studies are necessary to
confirm our results. © 2009 Springer-Verlag London Ltd.
AN - rayyan-563560625
AU - Romeo, U.
AU - Palaia, G.
AU - Botti, R.
AU - Leone, V.
AU - Rocca, J. P.
AU - Polimeni, A.
DO - 10.1007/s10103-009-0738-4
IS - 6
KW - chlorhexidine
povidone iodine
adult
aged
article
clinical article
clinical trial
controlled study
female
gingiva bleeding
human
laser
lavage
male
periodontal disease
periodontal pocket
periodontics
pilot study
potassium titanylphosphate laser
priority journal
therapy effect
LA - English
PY - 2010
SN - 0268-8921
SP - 891-899
ST - Non-surgical periodontal therapy assisted by potassium-titanyl-phosphate
laser: A pilot study
T2 - Lasers Med. Sci.
TI - Non-surgical periodontal therapy assisted by potassium-titanyl-phosphate
laser: A pilot study
VL - 25
ID - 13999
ER -
TY - JOUR
AB - Background: The use of antimicrobial chemotherapeutic agent has been proposed
as a means of reducing the levels of oral bacteria. Many chemotherapeutic agents
claim to have antimicrobial properties. Hence this in vitro study had been
undertaken. Methods: This in vitro study comprised of seven toothpastes which have
been tested for their antimicrobial activity against three oral pathogens namely,
Streptococcus mutans, Escherichia coli and Candida albicans by well agar diffusion
assay at the dilution of 1:1, 1:2, 1:4, 1:8 and 1:16. Results: Study results showed
that toothpaste 'five' with sodium fluoride and sylodent as main ingredients showed
maximum zone of inhibition against Streptococcus mutans where as against Candida
albicans, toothpaste 'six' with xylitol and sodium fluoride as main ingredients
showed maximum zone of inhibition. And against E. coli, toothpaste 'one' with
Triclosan and Zinc sulphate as main ingredients showed maximum zone of inhibition
among all toothpastes. It was observed that tooth paste 'six' with sodium fluoride
and Neem, Meswak as main ingredient showed minimum zone of inhibition against
Streptococcus mutans at 1:1 dilution among seven toothpastes used in the present
study. Conclusion: In the present study, it has been demonstrated that triclosan
containing toothpastes formulations are more effective in control of oral micro
flora.
AN - rayyan-563560402
AU - Roopavathi, K. M.
AU - Gopal, S. V.
AU - Pushpalatha, G.
AU - Bennadi, D.
AU - Renushri, B. V.
AU - Madhura, A. S.
DO - 10.5530/jyp.2015.3.8
IS - 3
KW - silica gel
sodium fluoride
toothpaste
triclosan
xylitol
zinc sulfate
agar diffusion
article
Azadirachta indica
Candida albicans
Escherichia coli
in vitro study
nonhuman
priority journal
Salvadora persica
LA - English
PY - 2015
SN - ["0975-1505", "0975-1483"]
SP - 187-193
ST - Antimicrobial efficacy of commercially available toothpastes - An in vitro
study
T2 - J. Young Pharm.
TI - Antimicrobial efficacy of commercially available toothpastes - An in vitro
study
VL - 7
ID - 13776
ER -
TY - JOUR
AB - Background: Horizontal bone loss is the most common periodontal problem
confronting the clinician but has received little attention. Platelet rich fibrin
(PRF) is a second generation platelet concentrate. The platelets, leucocytes,
growth factors and cytokines contained within PRF make it a healing biomaterial
with tremendous potential for bone and soft tissue regeneration. Aim: This
interventional clinical trial evaluates the clinical effectiveness of Autologous
Platelet Rich Fibrin (PRF) in the management of horizontal bony defects.Settings
and Design: Department of Periodontics. Design was Non Randomized Clinical Trial
with split mouth design. Materials and Methods: A total of 45 sites with horizontal
bone loss in 15 patients were studied, 15 sites were treated with PRF gel
(experimental group I) and 15 sites were treated with PRF gel and PRF membrane
(experimental group II). Control group (15 sites) were treated with open flap
debridement. Analysis: All the parameters were assessed at baseline and after nine
months which included Pocket Depth (PD), Clinical Attachment level (CAL), Gingival
Recession (REC) and Relative Crest Height (RCH). The mean changes at baseline and
after 9 months within each group were compared using Wilcoxon Signed Ranks Test.
The mean changes for each parameter between groups were compared using Kruskal
Wallis Test. Results: Re-evaluation at nine months revealed that all groups showed
a significant reduction in probing depth (1.1±0.38 mm in control, 1.73±0.53 mm in
group I, 1.7±0.45 mm in group II)(p<0.05) and clinical attachment gain (0.86±0.58
mm in control, 1.56±0.62 mm in group I, 1.7±0.52 in group II)(p<0.05) as compared
to baseline. Intergroup comparisons of reduction in probing depth and clinical
attachment gain showed significant differences in the experimental groups as
compared to control (p<0.05), but there was no significant difference between the
experimental groups (p>0.05). There was no significant difference in gingival
recession and radiographic bone levels at 9 months post surgery (p>0.05) in all the
three groups. Conclusions: Within the limitations of this study, it can be
concluded that, clinically the use of PRF in both gel and membrane form is more
effective than open flap debridement alone in the management of horizontal
periodontal defects at nine months post surgery.
AN - rayyan-563560415
AU - Rosamma Joseph, V.
AU - Sam, G.
AU - Vijay Amol, N.
DO - 10.7860/JCDR/2014/9948.5129
IS - 11
KW - amoxicillin
fibrin
paracetamol
unclassified drug
adult
alveolar bone loss
article
clinical article
controlled study
female
gingiva disease
human
male
mouth hygiene
musculoskeletal system parameters
postoperative care
relative bone crest height
LA - English
PY - 2014
SN - ["0973-709X", "2249-782X"]
SP - ZC43-ZC47
ST - Clinical evaluation of autologous platelet rich fibrin in horizontal alveolar
bony defects
TI - Clinical evaluation of autologous platelet rich fibrin in horizontal alveolar
bony defects
VL - 8
ID - 13789
ER -
TY - JOUR
AB - OBJECTIVES Periodontology is the branch of modern dentistry allows today to
save dental elements that in the past would have been considered hopeless.
Prevention, and therefore the lengthening of the life of each restored dental
element, starts with conservative therapy. Respect for the periodontium is in fact
a fundamental aspect of dental treatments and is a point that must be taken into
consideration at every stage of therapy. The purpose of this work is to highlight
the stages of performing a prosthetic treatment for the rehabilitation of a single
edentulous area in the presence of a previous failure. MATERIALS AND METHODS The
patient came to the attention of the authors complaining of masticatory discomfort
which arose suddenly while chewing a soft bolus. The intra-oral examination detects
the fracture of a previous prosthetic bridge on natural abutments 4.5 and 4.7.
Phosphor radiographs were then taken with bite-wing and periapical techniques to
assess the abutments recoverability. After the removal of the previous
restorations, the cleaning of the carious lesions and the preparation of the new
prosthetic abutments were carried out using rotating instruments mounted on contra-
angle handpieces with blue ring and red ring respectively mounted on micromotor.
For endodontic therapy, reciprocating instruments mounted on a speed reduction
handpiece on a dedicated endodontic motor and nickel-titanium manual instruments
were used for the canal instrumentation, sodium hypochlorite and EDTA gel for the
chemical disinfection, zinc-oxide and eugenol based cement and gutta-percha heated
through a hot vertical condensation technique for obturation. The reconstruction of
the abutments took place under isolation with a rubber dam, using a nanofilled mass
composites and a fiberglass post adhesively cemented with dual, chemical and
luminous activation, composite cement. The surgical phase for the lengthening of
the clinical crown involved the use of diamond burs mounted on a speed multiplier
handpiece, diamond ultrasonic inserts mounted on a piezosurgery handpiece and
manual chisels for ostectomy. The implant phase required the use of a grade 5
titanium implant treated using the SLA technique. For the final prosthetic phase,
lithium disilicate for the prosthetic crowns and composite for the onlay
restoration and the layered substrate on the implant abutment were used. For the
finishing and polishing phase, of minimal entity, discs with variable granulometry,
rotating rubbers, goat hair brushes and brightening pastes (aluminum oxide) were
used. The contact points were tested using dental floss and super floss. RESULTS
AND CONCLUSIONS The result obtained in this work is comparable to those already
widely reported in the literature. The respect of key concepts such as the
tightness of the contact points, the precise management of the finishing lines, the
extra- gingival localization of the tooth-restoration areas, guarantee the long-
term maintenance of periodontal health and therefore allow to obtain a long-term
success of the prosthetic treatment. CLINICAL SIGNIFICANCE This clinical case
demonstrates how the good state of health both of the apical periodontium and,
above all, of the marginal periodontium, are fundamental for the long-term success
of any dental treatment. Each phase of the multidisciplinary restorative-surgical-
prosthetic therapy must be guided by this assumption.
AN - rayyan-563559773
AU - Roselli, G.
AU - Carretta, G.
AU - Carbonara, F.
AU - Bruno, L.
AU - Mezzapesa, P. P.
DO - 10.19256/d.cadmos.05.2023.08
IS - 5
KW - cofferdam
dental floss
gutta percha
hypochlorite sodium
zinc oxide
article
bone resection
edentulism
human
mouth examination
piezosurgery
prosthetic procedure
radiography
LA - Italian
PY - 2023
SN - 0011-8524
SP - 408-416
ST - Surgical-conservative-prosthetic treatment in a case of single edentulism
T2 - Trattamento protesicoconservativo-chirurgico di un caso di edentulia singola
TI - Surgical-conservative-prosthetic treatment in a case of single edentulism
VL - 91
ID - 13147
ER -
TY - JOUR
AB - The safety and efficacy of a home-use carbamide peroxide tooth-whitening
procedure were evaluated in a double-blind experimental design. Fifty-two adults
were randomly assigned to experimental and control (placebo gel) groups. The
products were applied in a custom-fitted tray and used for 5 consecutive nights in
accordance with the manufacturer's recommendations. Tooth color changes from
baseline were measured with a small-area colorimeter. Concurrently, electric pulp
test and periodontal indices were measured. At the end of 6 months, the teeth in
the active group had a statistically significant greater mean color change that did
the placebo controls. The mean color change differed significantly by tooth type.
No statistically significant changes in vitality, sulcus depth, or Gingival Index
were found in the treatment group.
AN - rayyan-563561062
AU - Rosenstiel, S. F.
AU - Gegauff, A. G.
AU - Johnston, W. M.
IS - 6
peroxide
tooth bleaching agent, Opalescence
tooth-bleaching agent, Opalescence
urea
carbamide peroxide
adult
article
clinical trial
colorimetry
controlled study
dental procedure
dental device
drug combination
female
human
incisor
male
middle aged
multivariate analysis
periodontics
tooth pulp disease
LA - English
PY - 1996
SN - 0033-6572
SP - 413-424
ST - Randomized clinical trial of the efficacy and safety of a home bleaching
procedure
TI - Randomized clinical trial of the efficacy and safety of a home bleaching
procedure
VL - 27
ID - 14436
ER -
TY - JOUR
AB - OBJECTIVES: A 10-week, double-blind, placebo-controlled clinical study on 140
male subjects was conducted to determine the effect on plaque and gingivitis of 5
dentifrices containing various thiocyanate (SCN-)/hydrogen peroxide (H2O2)
combinations. MATERIALS AND METHODS: The dentifrices consisted of a gel base
without any detergents or abrasives (placebo, group A) to which SCN- and/or H2O2
were added as follows: 0.1% SCN- (group B), 0.5% SCN- (group C), 0.1% SCN-/0.1%
H2O2 (group D), 0.5% SCN-/0.1% H2O2 (group E) and 0.1% H2O2 (group F). A baseline
examination was performed in which the Silness and Löe Plaque Index (PI), the
Mühlemann and Son Sulcus Bleeding Index (SBI), and the amount of gingival
crevicular fluid (GCF) were recorded using the Periotron 6,000 on teeth 16, 12, 24,
36, 32, and 44. The subjects were randomly assigned to either the placebo group (n
= 40) or one of the test groups (n = 20) and used their respective dentifrices over
a period of 8 weeks. Finally, each group used the placebo for another 2 weeks
(wash-out). Re-examinations were performed after 1, 4, and 8 weeks and the 2-week
wash-out period employing the clinical parameters used at baseline. Intragroup
changes were analyzed with the Wilcoxon signed-ranks test, using the baseline and
wash-out points as references. The Mann-Whitney U test was used for comparisons
between the treatment groups and the placebo group. RESULTS: At the 8-week
examination, the plaque index in group E (p = 0.017) and group F (p = 0.032) was
lower than in the placebo group. The Sulcus Bleeding Index in group F after 1 week
was increased (p = 0.023) and the SBI in group E after 8 weeks was reduced (p =
0.047) as compared to the placebo group. CONCLUSION: The results demonstrated that
a dentifrice containing 0.5% SCN- and 0.1% H2O2 but no detergents or abrasives
inhibited plaque and decreased gingivitis.
AN - rayyan-563560925
AU - Rosin, M.
AU - Kocher, T.
AU - Kramer, A.
IS - 3
placebo
thiocyanate
thiocyanic acid derivative
toothpaste
adolescent
adult
article
clinical trial
comparative study
controlled study
drug combination
drug effect
follow up
gel
gingiva bleeding
gingivitis
human
male
nonparametric test
observer variation
periodontics
reproducibility
tooth plaque
LA - English
PY - 2001
SN - 0303-6979
SP - 270-276
ST - Effects of SCN-/H2O2 combinations in dentifrices on plaque and gingivitis
TI - Effects of SCN-/H2O2 combinations in dentifrices on plaque and gingivitis
VL - 28
ID - 14299
ER -
TY - JOUR
AB - Histatins are a family of histidine-rich, cationic peptides composed of up to
38 amino acids. They are secreted by the salivary glands of humans and some
subhuman primates and are thought to be part of the host defence system in the oral
cavity. Histatins exhibit in vitro activity against both bacteria and yeast, common
to other antimicrobial peptides. Because of these activities, histatin-based
peptides could play an important role in the treatment and prevention of infectious
diseases. A 12 amino acid amidated fragment of histatin 5, designated P-113, has
been identified as the smallest fragment that retains antimicrobial activity
comparable to the parent compound. Animal studies and human clinical trials showed
that P-113 has potential in preventing the development of gingivitis, with no
adverse side effects. Histatin peptides also could be used for other therapeutic
applications in which the infection is localised and accessible via topical
delivery, such as treatment of candidiasis (thrush) and mucositis in the oral
cavity, skin infections and treatment of lung infections afflicting cystic fibrosis
patients.
AN - rayyan-563560900
AU - Rothstein, D. M.
AU - Helmerhorst, E. J.
AU - Spacciapoli, P.
AU - Friden, P.
DO - 10.1517/14728214.7.1.47
IS - 1
histatin
histatin 1
histatin 3
histatin 5
peptide
placebo
saralasin
unclassified drug
Candida albicans
clinical trial
cystic fibrosis
dog
drug efficacy
drug mechanism
drug safety
gel
gingivitis
human
infection
lung infection
mouthwash
mucosa inflammation
periodontal disease
review
side effect
skin infection
structure activity relation
thrush
p 113
LA - English
PY - 2002
SN - 1472-8214
SP - 47-59
ST - Histatin-derived peptides: Potential agents to treat localised infections
T2 - Expert Opin. Emerg. Drugs
TI - Histatin-derived peptides: Potential agents to treat localised infections
VL - 7
ID - 14274
ER -
TY - JOUR
AB - To assess the anti-plaque and anti-gingivitis effects of a dentifrice
containing 0.3% triclosan, 2% copolymer and 0.243% (1,100 ppm) sodium fluoride in
subjects with moderate plaque-induced gingivitis. This was a single center, monadic
study. Subjects had at least 20 teeth remaining in the functional dentition,
excluding third molars. Following a baseline examination for plaque, gingival
inflammation and bleeding, 75 qualified healthy adult males and females, ages 18-70
were selected to participate in the study. Dental prophylaxis was performed and
subjects were provided with two tubes of toothpaste (Colgate Total) and a soft-
bristle toothbrush (Colgate Wave Toothbrush). The subjects were instructed to brush
twice daily using a modified Bass brushing technique. At the end of the 6- to 8-
week period subjects returned for collection of clinical and subjective data. 75
subjects completed the study. Both clinical and subjective reductions were
significant. The results showed statistically significant reductions in plaque
index, gingival inflammation and bleeding on probing. The overall conclusion was
that Colgate Total was a comprehensive dentifrice that produced a significant
reduction in gingivitis, plaque, and bleeding.
AN - rayyan-563560448
AU - Rover, J. A.
AU - Leu-Wai-See, P.
IS - 3
silicic acid
sodium fluoride
toothpaste
triclosan
adolescent
adult
aged
article
comparative study
controlled study
devices
female
follow up
gingiva bleeding
gingivitis
human
male
methodology
middle aged
periodontics
prospective study
tooth brushing
tooth plaque
treatment outcome
young adult
LA - English
PY - 2014
SN - 0894-8275
SP - 167-170
ST - Role of Colgate Total toothpaste in helping control plaque and gingivitis
T2 - Am J Dent
TI - Role of Colgate Total toothpaste in helping control plaque and gingivitis
VL - 27
ID - 13822
ER -
TY - JOUR
AB - In this study, a thermoresponsive gel for minocycline (MCL) with chitosan/β-
glycerophosphate (C/β-GP) was formulated and its characterization, in vitro
release, stability, toxicity and pharmacodynamics were investigated. The
formulation containing MCL was prepared by pouring the chitosan solution directly
onto the sterilized drug powder and stirring before mixing with the β-
glycerophosphate (β-GP) solution. The final preparations contained 0.5% (w/v)
chitosan, 1.8% (w/v) β-GP and 2% (w/v) MCL. The drug content of prepared gels was
in the range of 92-99%, and the pH value of the optimized formulation was found to
be 5.6-6.2. The gelation temperature of the prepared C/β-GP thermogelling solutions
was 37 °C. Color, consistency, pH, viscosity and drug content of the in situ gels
were found to be consistent, and no signs of separation and deterioration were
observed over a period of 90 d. In vivo studies showed that rats' liver and kidney
tissue sections were normal, with no structural damage. The constituents of the in
situ gels formulation had a well-sustained release efficacy on the animal model of
periodontitis.
AN - rayyan-563560353
AU - Ruan, H.
AU - Yu, Y.
AU - Liu, Y.
AU - Ding, X.
AU - Guo, X.
AU - Jiang, Q.
DO - 10.3109/10717544.2014.929195
IS - 2
KW - chitosan
minocycline
animal experiment
animal model
article
controlled study
drug efficacy
drug release
female
gelation
histocompatibility
hydrogel
in vitro study
in vivo study
kidney parenchyma
male
molecular weight
nonhuman
pH
priority journal
rat
viscometry
viscosity
LA - English
PY - 2016
SN - ["1521-0464", "1071-7544"]
SP - 525-531
ST - Preparation and characteristics of thermoresponsive gel of minocycline
hydrochloride and evaluation of its effect on experimental periodontitis models
T2 - Drug Deliv.
TI - Preparation and characteristics of thermoresponsive gel of minocycline
hydrochloride and evaluation of its effect on experimental periodontitis models
VL - 23
ID - 13727
ER -
TY - JOUR
AB - The purpose of this investigation was to evaluate the clinical and
microbiological effect of local antibiotic therapy in comparison with subgingival
scaling and root planing in a randomized semi-masked study. Forty-six recall
patients who completed systematic periodontal therapy 6 to 24 months prior to the
study were enrolled. The inclusion requirements were at least one site with probing
depth ≥ 5 mm in each quadrant, no scaling, and no antibiotic therapy during the
last 6 months. After randomization each patient received 2 different treatments: in
2 quadrants metronidazole 25% dental gel was applied subgingivally to the pockets
at day 0 and day 7; scaling and root planing was carried out in the 2 other
quadrants, one at day 0 and in the remaining quadrant at day 7. Subgingival
microbiological samples were taken from each patient before treatment and on days
21, 91, and 175 after the treatment. The analyses were carried out by indirect
immunofluorescence assay. At all treated sites probing depth (PD), clinical
attachment level (CAL), and bleeding on probing (BOP) were recorded on days 0, 21,
91, and 175. Both treatments resulted in PD reduction and CAL gain. PD reduction
was statistically significant (P < 0.01) for both treatment modalities after 6
months. The CAL gain was not significant for either treatment. There was no
statistical significance between scaling and antibiotic therapy. Treponema
denticola, Prophyromonas gingivalis, and Prevotella intermedia were significantly
reduced after therapy; however, there were no statistically significant differences
between treatments. If Actinobacillus actinomycetemcomitans was present before
therapy, it was also present after treatment in both groups. The conclusion is
that, in recall patients, local application of metronidazole and scaling and root
planing showed similar clinical and microbiological effects without statistically
significant differences.
AN - rayyan-563561021
AU - Rudhart, A.
AU - Purucker, P.
AU - Kage, A.
AU - Hopfenmüller, W.
DO - 10.1902/jop.1998.69.10.1148
IS - 10
KW - metronidazole
adult
antibiotic therapy
article
bacterium detection
clinical article
clinical trial
controlled study
female
gingiva disease
human
male
LA - English
PY - 1998
SN - 0022-3492
SP - 1148-1154
ST - Local metronidazole application in maintenance patients. Clinical and
TI - Local metronidazole application in maintenance patients. Clinical and
VL - 69
ID - 14395
ER -
TY - JOUR
AB - The opportunity of use stimulated by sucrose solutions and urea test pH
changes of the mixed saliva were investigated with the purpose of an estimation of
efficiency of antiseptic and hygienic means action. Research is carried out on 37
students who have been specially picked up in 3 groups: "A" -- with low activity of
caries without periodontitis, "B" -- caries-susceptible and "C" -- with gingivitis
and periodontitis. It appeared possible with the help of pH-measuring of saliva to
compare antiseptic action in an oral cavity of 4 popular antiseptics: the combined
gel with chlorhexidine and metronidazole, and also anticarious toothpaste in the
form of application and in combination with cleaning teeth by a brush. The offered
tests allow to reveal primary action of antiseptic means for the microflora causing
either caries or inflammatory periodontal disease.
AN - rayyan-563560782
AU - Rumiantsev, V. A.
AU - Iusufov, M. V.
AU - Khiutti, N. V.
AU - Moskaleva, I. V.
AU - Slobodina, E. V.
IS - 4
KW - chlorhexidine
metronidazole
toothpaste
adult
article
bacterium
chemistry
comparative study
dental caries
drug effect
evaluation study
female
human
male
microbiology
mouth
mouth hygiene
periodontitis
pH
saliva
tooth brushing
LA - Russian
PY - 2005
SN - 0039-1735
SP - 4-7
ST - Comparative study by pH-tests of the efficacy of antimicrobial agents in oral
cavity
TI - Comparative study by pH-tests of the efficacy of antimicrobial agents in oral
cavity
VL - 84
ID - 14156
ER -
TY - COMP
AB - The opportunity of use stimulated by sucrose solutions and urea test pH
changes of the mixed saliva were investigated with the purpose of an estimation of
efficiency of antiseptic and hygienic means action. Research is carried out on 37
students who have been specially picked up in 3 groups: "A" -- with low activity of
caries without periodontitis, "B" -- caries-susceptible and "C" -- with gingivitis
and periodontitis. It appeared possible with the help of pH-measuring of saliva to
compare antiseptic action in an oral cavity of 4 popular antiseptics: the combined
gel with chlorhexidine and metronidazole, and also anticarious toothpaste in the
form of application and in combination with cleaning teeth by a brush. The offered
tests allow to reveal primary action of antiseptic means for the microflora causing
either caries or inflammatory periodontal disease.
AN - rayyan-563561453
AU - Rumiantsev, V. A.
AU - Iusufov, M. V.
AU - Khiutti, N. V.
AU - Moskaleva, I. V.
AU - Slobodina, E. V.
CY - Russia (Federation)
ET - 4
J2 - Stomatologiia (Mosk)
KW - Adult
Anti-Infective Agents, Local/*pharmacology
Dental Caries/microbiology
Female
Humans
Male
Metronidazole/pharmacology
*Microbial Sensitivity Tests
Mouth/*microbiology
Oral Hygiene
Periodontitis/microbiology
Saliva/*chemistry/microbiology
Toothbrushing
Toothpastes/pharmacology
LA - rus
PY - 2005
SN - 0039-1735 (Print)
SP - 4-7
ST - [Comparative study by pH-tests of the efficacy of antimicrobial agents in
oral cavity]
T2 - Stomatologiia
TI - [Comparative study by pH-tests of the efficacy of antimicrobial agents in
oral cavity]
VL - 84
ID - 14827
ER -
TY - CONF
AN - rayyan-563561703
AU - Rusminah, N.
AU - Rusyanti, Y.
AU - Susanto, A.
AU - Rini, T. C.
DA - 2020
SP - 220-225
ST - The effect of green betle leaf gel (Piper betle leaf) to total antioxidant
capacity (tac) level after scaling and root planing (srp) treatment
TI - The effect of green betle leaf gel (Piper betle leaf) to total antioxidant
capacity (tac) level after scaling and root planing (srp) treatment
%2fKEM.829.220&partnerID=40&md5=5586803b604ac04388ae32aaf2f63a82
VL - 829
ID - 15077
ER -
TY - JOUR
AB - OBJECTIVES: To evaluate the clinical, microbiological and enzymatic activity
of a hydrophobic chlorhexidine-based gingiva-adhering gel containing herbal
ingredients, compared with a commercially available 1% chlorhexidine water-soluble
gel, during non-surgical therapy of moderate chronic periodontitis. METHODS: A
total of 34 subjects participated in this 6-month blinded randomized parallel
controlled trial (ISRCTN35210084). After scaling and root planing (SRP), test group
received the gel, by rubbing on the gingiva, once every second day, for 14 days.
The control group received the control gel twice daily. Clinical parameters
considered were the approximal plaque index, simplified oral hygiene index,
modified gingival index, bleeding on probing, probing depth and clinical attachment
level (primary outcome), assessed at baseline, 3 and 6 months, together with the
frequency of detection of Aggregatibacter actinomycetemcomitans, Porphyromonas
gingivalis (P.g.), Prevotella intermedia, Treponema denticola (T.d.), Tannerella
forsythia (T.f.), and activity of neutrophil elastase and myeloperoxidase
(secondary outcomes). RESULTS: At 3 and 6 months, all clinical parameters improved
significantly, without significant intergroup differences, except OHI-S, which
improved at 3 months (P < 0.05). Microbiological data resulted in no significant
intergroup differences at baseline and 6 months. At 3 months, significant
differences for P.g., T.f. and T.d. were noted. A significant reduction of
neutrophil elastase after 3 and 6 months was observed (P < 0.005), without
significant intergroup differences. For myeloperoxidase, significant reductions
were noted in both groups (P < 0.005 and P < 0.05), but no significant intergroup
differences. The tested product seemed to have an increased efficacy, due to longer
persistence on the gingiva, with reduced application frequency. CONCLUSIONS: Both
products had a relatively similar influence on the clinical, microbiological and
enzymatic outcomes at 3 and 6 months after SRP.
AN - rayyan-563560313
AU - Rusu, D.
AU - Stratul, S. I.
AU - Sarbu, C.
AU - Roman, A.
AU - Anghel, A.
AU - Didilescu, A.
AU - Jentsch, H.
DO - 10.1111/idh.12155
IS - 1
KW - chlorhexidine
leukocyte elastase
peroxidase
adult
aged
chemical phenomena
comparative study
controlled study
dental scaling
drug effect
female
gel
gingiva
human
male
metabolism
microbiology
middle aged
procedures
root planing
therapeutic use
LA - English
PY - 2017
SN - 1601-5037
SP - 53-64
ST - Evaluation of a hydrophobic gel adhering to the gingiva in comparison with a
standard water-soluble 1% chlorhexidine gel after scaling and root planing in
patients with moderate chronic periodontitis. A randomized clinical trial
T2 - Int J Dent Hyg
TI - Evaluation of a hydrophobic gel adhering to the gingiva in comparison with a
standard water-soluble 1% chlorhexidine gel after scaling and root planing in
patients with moderate chronic periodontitis. A randomized clinical trial
VL - 15
ID - 13687
ER -
TY - JOUR
AB - This paper examines the effects of smoking on the treatment outcomes of two
nonsurgical therapies: (1) scaling and root planing alone (SRP) or (2) controlled-
release of subgingivally delivered doxycycline hyclate in a polylactic acid based
polymer gel. Subjects from 2 9-month multicenter studies were classified as
nonsmokers (never smoked: 100 subjects), former smokers (137 subjects), and current
smokers (> or = 10 cigarettes/day: 121 subjects). Clinical parameters were analyzed
for treated sites with baseline probing depths > or = 5 mm and for a subset of
treated sites with baseline probing depths of > or = 7 mm. Clinical parameters
(plaque levels, clinical attachment levels, pocket depths, and bleeding on probing)
were analyzed at baseline, 4, 6, and 9 months. In the doxycycline treated group in
general, there were neither marked significant differences in clinical attachment
gain nor differences in probing depth reduction among the 3 smoking groups. On the
other hand, in the scaling and root planing treated group in general, there were
significant differences in clinical attachment gain and pocket depth reduction,
with non-smokers responding better than former smokers and current smokers at 6 and
9 months. These differences in clinical response between scaling and root planing
alone versus controlled-release of locally-delivered doxycycline hyclate among
these 3 smoking groups are discussed in relation to treatment implications for
smokers.
AN - rayyan-563561004
AU - Ryder, M. I.
AU - Pons, B.
AU - Adams, D.
AU - Beiswanger, B.
AU - Blanco, V.
AU - Bogle, G.
AU - Donly, K.
AU - Hallmon, W.
AU - Hancock, E. B.
AU - Hanes, P.
AU - Hawley, C.
AU - Johnson, L.
AU - Wang, H. L.
AU - Wolinsky, L.
AU - Yukna, R.
AU - Polson, A.
AU - Carron, G.
AU - Garrett, S.
IS - 10
doxycycline
doxycycline hyclate
drug derivative
lactic acid
polylactic acid
polymer
article
clinical trial
comparative study
controlled study
follow up
gingiva bleeding
human
middle aged
multicenter study
pathophysiology
periodontal disease
periodontitis
smoking
tooth plaque
treatment outcome
LA - English
PY - 1999
SN - 0303-6979
SP - 683-691
ST - Effects of smoking on local delivery of controlled-release doxycycline as
compared to scaling and root planing
TI - Effects of smoking on local delivery of controlled-release doxycycline as
compared to scaling and root planing
VL - 26
ID - 14378
ER -
TY - JOUR
AB - A total of 89 specimens have included 34 swabs of periodontitis( 13male,21
female),28 swabs of Otitis Media & 27 swabs of Tonsillitis. These samples were
brought from patients consulted to Alhashmia Hospital, primary care centers &
private clinic of Babylon province during the period from 5 October 2017 to
11December 2017. They were appeared (72.17)% positive cases for Streptococcus
pyogenes which have gotten from patients within age ranged, which suffered from Ear
infection ( 3 to 39 years), Tonsillitis(1 to 60 years) & periodontitis
inflammation(from less than 3years to 60 years). Biochemical examinations have
included oxidase, catalase & Antibiotics sensitivity test. Results of bacterial
genetics detection of sic as responsible for virulence agents of isolates bacteria,
which is responsible for damage host cell components. 50 patterns (55.3%) of S.
pyogenes cases of otitis media, tonsillitis & gingivitis have positive exclude
39(44.7) isolates were negative on 3% agarose gel. The volume of sic gene was 150
bp of the DNA, ladder (100 – 1000 )bp. This gene of S. pyogenes specimens has
amplified by PCR utilizing specific forward & reverse primers have appeared that 50
Streptococcus isolates detection of Otitis Media., Tonsillitis & periodontitis
infections have negative 27 (90%) except 2 ( 10%) isolates were positive.
AN - rayyan-563560205
AU - Saad, A. M.
AU - Aljarah, A. K.
AU - Alkhafaji, N. M. S.
AU - Kadhim, W. A.
DO - 10.5958/0976-5506.2019.00164.5
IS - 1
ampicillin
azithromycin
bacterial protein
ceftazidime
chloramphenicol
doxycycline
erythromycin
ethylhydrocupreine
meticillin
metronidazole
rifampicin
streptococcal inhibitor of complement mediated lysis protein
tetracycline
tobramycin
trimethoprim
unclassified drug
acute otitis media
article
bacterial virulence
clinical article
controlled study
female
human
Lactobacillus
male
nonhuman
periodontitis
sequence homology
tonsillitis
zone of inhibition
LA - English
PY - 2019
SN - ["0976-5506", "0976-0245"]
SP - 840-845
ST - Molecular & antibiotic sensitivity pattern study of acute otitis media,
tonsillitis & periodontitis among different ages of patients of al-hashmia general
hospital, primary care centers & private clinic in babylon province
TI - Molecular & antibiotic sensitivity pattern study of acute otitis media,
tonsillitis & periodontitis among different ages of patients of al-hashmia general
hospital, primary care centers & private clinic in babylon province
VL - 10
ID - 13579
ER -
TY - JOUR
AB - Objectives: Productive Herpesviridae infections are implicated in the etio-
pathogenesis of aggressive periodontitis. However, virtually nothing is known about
a possible role of herpesviruses in pulpal and periapical pathosis. This study
employed a cDNA analysis to determine transcription of human cytomegalovirus
(HCMV), Epstein-Barr virus (EBV) and herpes simplex virus (HSV) in 14 recalcitrant
periapical lesions and in 2 periapical healthy control sites. Methods: Periapical
samples were collected in conjunction with periapical surgery and kept frozen until
virologic examination. RNA was isolated from periapical tissue by using a
guanidinium isothiocyanate-acid phenol procedure (TRIZOL LS Reagent, GIBCO BRL,
Rockville, MD). cDNAs were amplified by means of oligonucleotides targeting highly
conserved regions of the test viruses and the RT-PCR-100 amplification kit (Sigma-
Aldrich, St Louis, MO). Standardization of PCR primer sensitivity and validation
was carried out according to established methods. Amplification products were
identified by agarose gel electrophoresis. Results: HCMV transcript was detected in
12 of 13 symptomatic and in 1 asymptomatic periapical lesion. EBV transcript was
demonstrated in 8 of the 13 symptomatic lesions but not in the asymptomatic
periapical lesion. HCMV and EBV dual transcription occurred at higher frequency in
periapical lesions showing radiographic bone destruction of 5 mm × 7 mm or larger
than in smaller size lesions (P = 0.03; Chi-squared test). No HCMV or EBV
transcription was identified in the 2 healthy control sites. HSV transcript was not
detected in any study site. Conclusion: The present data suggest that HCMV or EBV
infections participate in the pathogenesis of periapical symptomatic lesions.
Herpesviruses may produce periapical pathosis as a direct result of viral infection
and replication, or as a consequence of virally induced impairment of the host
defense and subsequent increased virulence of resident bacterial pathogens.
AN - rayyan-563560887
AU - Sabeti, M.
AU - Valles, Y.
AU - Nowzari, H.
AU - Simon, J. H.
AU - Kermani-Arab, V.
AU - Slots, J.
DO - 10.1034/j.1399-302X.2003.00055.x
IS - 2
KW - complementary DNA
guanidine
isothiocyanic acid
phenol
RNA
virus DNA
article
bone destruction
clinical article
Epstein Barr virus
human
Human cytomegalovirus
human tissue
nonhuman
virus detection
virus pathogenesis
virus transcription
virus virulence
LA - English
PY - 2003
SN - 0902-0055
SP - 104-108
ST - Cytomegalovirus and Epstein-Barr virus DNA transcription in endodontic
symptomatic lesions
TI - Cytomegalovirus and Epstein-Barr virus DNA transcription in endodontic
symptomatic lesions
VL - 18
ID - 14261
ER -
TY - JOUR
AB - BACKGROUND: The prevalence of denture stomatitis has been shown to vary from
15 to 65% in complete denture wearers. Satureja hortensis L. has been considered to
have antinociceptive, anti-inflammatory, antifungal and antimicrobial activities in
vitro and exhibits strong inhibitory effect on the growth of periodontal bacteria.
The aim of this study was to evaluate the efficacy of a 1% gel formulation of S.
hortensis essential oil for the treatment of denture stomatitis. MATERIALS AND
METHODS: A randomized, controlled clinical trial study was conducted on 80 patients
(mean age 62.91±7.34) in two parallel groups treated either with S. hortensis
essential oil 1% gel or placebo applied two times daily for two weeks. Denture
stomatitis was diagnosed by clinical examination and paraclinical confirmation with
sampling the palatal mucosa for Candida albicans. Data were analyzed using Chi-
squared or Student's t tests. RESULTS: The erythematous lesions of palatal area
were significantly reduced (P<0.0001) in the treatment group who applied 1% topical
gel of S. hortensis essential oil and Candida colonies count were reduced
significantly (P=0.001). CONCLUSION: Topical application of the essential oil of S.
hortensis could be considered as an effective agent for the treatment of denture
stomatitis.
AN - rayyan-563561314
AU - Sabzghabaee, A. M.
AU - Davoodi, N.
AU - Ebadian, B.
AU - Aslani, A.
AU - Ghannadi, A.
DO - 10.4103/1735-3327.95236
IS - 2
J2 - Dent Res J (Isfahan)
LA - eng
N1 - Isfahan Clinical Toxicology Research Center, Isfahan University of Medical
Sciences, Isfahan, Iran.
PY - 2012
SP - 198-202
ST - Clinical evaluation of the essential oil of "Satureja Hortensis" for the
treatment of denture stomatitis
T2 - Dental research journal
TI - Clinical evaluation of the essential oil of "Satureja Hortensis" for the
treatment of denture stomatitis
VL - 9
Y2 - 3
ID - 14688
ER -
TY - JOUR
AN - rayyan-563561593
AU - Șachir, E. E.
AU - Pușcașu, C. G.
AU - Caraiane, A.
AU - Raftu, G.
AU - Badea, V.
AU - Bartok-Nicolae, C.
AU - Grierosu, C.
AU - Feier, R.
DO - 10.3390/app12030998
IS - 3
PY - 2022
ST - Radioimaging in the Evaluation of the Therapeutic Effect of the Vegetable
Extract Obtained from Epilobium Parviflorum Schreb
TI - Radioimaging in the Evaluation of the Therapeutic Effect of the Vegetable
85123078832&doi=10.3390%2fapp12030998&partnerID=40&md5=47a8877a8f3cffe401b5ecff8e58
609a
VL - 12
ID - 14967
ER -
TY - JOUR
AB - For years, apical microleakage has been considered the main factor in
endodontic failure therapy. Sealing abilities and antibacterial properties of root
canal sealers and intracanal medicaments between appointments have been recognized
as important factors for the success of endodontic treatment. Background: Apical
periodontitis (AP) is an inflammatory disease around the apex of a tooth root. The
microorganisms reach the pulp by dentinal tubules especially when there is an open
cavity after a coronal fracture and the pulp is in contact with the septic oral
environment. The aim of the study was to evaluate the dynamics of healing by
recording periapical index (PAI), after two appointment endodontic procedure with
commercial or experimental intracanal medicament. Methods: A total of 40 patients
with primary chronic apical periodontitis requiring root canal treatment were
assigned randomly into four groups according to the teeth medicated with dehydrated
plant extract, calcium hydroxide, calcium hydroxide mixed with chlorhexidine (CHX)
gel 2%, Walkhoff paste and obturated on a second visit, 7 days later. Patients were
recalled at intervals of 3, 6, and 12 months to evaluate the treated teeth both
clinically and radiographically for periapical healing. A 5-score scale PAI was
used to evaluate stages of the periapical healing on a periapical radiography using
a Kodak Dental imaging software provided by the radio-imagistic center. Results:
Radiological evaluation revealed that the experimental intracanal medicament had a
cumulative positive healing capacity by reducing the PAI as well as all resorbable
pastes used in endodontic conventional therapy. Conclusions: The results suggest
that the vegetable dry extract obtained from Epilobium parviflorum Schreb can be
used as an inter-appointment medication among with the root canal filling for the
positive effect on apical healing quantified by reducing the PAI.
AN - rayyan-563562571
AU - Sachir, E. E.
AU - Puscasu, C. G.
AU - Caraiane, A.
AU - Raftu, G.
AU - Badea, V.
AU - Bartok-Nicolae, C.
AU - Grierosu, C.
AU - Feier, R.
DO - 10.3390/app12030998
IS - 3
PY - 2022
SN - 2076-3417
ST - Radioimaging in the Evaluation of the Therapeutic Effect of the Vegetable
TI - Radioimaging in the Evaluation of the Therapeutic Effect of the Vegetable
VL - 12
Y2 - 2
ID - 15945
ER -
TY - JOUR
AB - Background: The use of absorbable gelatin sponges (AGSs) as a hemostatic
surgical material resulted in a reduction of dry sockets occurrence. The systemic
use of antibiotics and antimicrobial agents can also reduce the infection of
extracted teeth, and therefore, it may show pain-relieving effects on the dry
socket as well. Objective: Given the high prevalence of dry sockets in the
extracted teeth, the main objective of this review was a brief overview of AGSs,
including antimicrobial agents to prevent dry sockets. Methods: The electronic
search of the literature was done on the Pubmed and Google Scholar databases with
the MESH keywords of Antimicrobials, Gelatin sponge, Gelfoam, Dry socket,
Antibiotics, Alveolar osteitis. Only papers published in English were investigated.
No limitations were put on the publication date. Results: Of the 279 electronic
papers, 79 articles were found relevant to the study. All abstracts were reviewed,
and only desired articles were selected. The final electronic and manual search led
to 15 articles for use in this study. Among these studies, 5 studies were related
to AGSs, including antimicrobial agents to prevent dry sockets. Conclusion: The
reviewed literature showed that the systemic/topical use of antibiotics and
antimicrobial agents can reduce infection and, therefore, may show pain-relieving
effects on the dry socket. Besides, antimicrobial-loaded AGSs can be helpful in
curing or preventing dry sockets. There were a limited number of clinical trials
that used antimicrobial loaded AGSs for dry socket. More clinical studies are
needed, especially in subgroups of patients with a high risk of infectious
conditions, to validate the effectiveness of antimicrobial-loaded AGSs for dry
socket.
AN - rayyan-563562518
AU - Sadeghi, S. H.
AU - Sharifi, S.
AU - Dizaj, S. M.
AU - Ghavimi, M. A.
AU - Shahi, S.
AU - Ghoreishizadeh, A.
AU - Negahdari, R.
DO - 10.2174/18742106-v16-e2208111
PY - 2022
SN - 1874-2106
ST - Antimicrobial agent containing absorbable gelatin sponge to prevent dry
socket: A systematic review
T2 - OPEN DENTISTRY JOURNAL
TI - Antimicrobial agent containing absorbable gelatin sponge to prevent dry
socket: A systematic review
VL - 16
ID - 15892
ER -
TY - JOUR
AB - Aim: To evaluate the antibacterial efficacy of double antibiotic paste (DAP),
silver nanoparticle (AgNP) gel, and tailored amorphous multiporous bioactive glass
(TAMP-BG) in concentrations suitable for regenerative endodontics (RE) against 3-
week-old Enterococcus faecalis biofilms after 24 hours and 7 days. Results:
Radicular human dentin specimens were prepared and inoculated with E. faecalis to
form 3-week-old biofilms. DAP (1 mg/mL), AgNPs 0.02%, and TAMP-BG 100 mg/mL, in
methylcellulose gel formulations, were used as antimicrobials. The biofilm
disruption assay was done followed by quantification of bacterial colony-forming
units and scanning electron microscopic analysis. Results showed that 1 mg/mL of
DAP or AgNPs 0.02% provided significant antibiofilm effects at both time intervals.
Both DAP and AgNPs significantly reduced bacterial counts and biofilms after 7 days
compared with 24 hours. Furthermore, 100 mg/mL of TAMP-BG had a comparable
antibiofilm effect, but it was less potent than DAP and AgNPs at both time
intervals. Conclusions: DAP (1 mg/mL), 0.02% AgNPs, and TAMP-BG (100 mg/mL) can
significantly reduce E. faecalis biofilms. However, complete elimination was only
possible with DAP and AgNPs.
AN - rayyan-563562529
AU - Sadek, R. W.
AU - Moussa, S. M.
AU - El Backly, R. M.
AU - Hammouda, A. F.
DO - 10.1089/mdr.2018.0228
IS - 5
PY - 2019
SN - ["1076-6294", "1931-8448"]
SP - 761-771
ST - Evaluation of the Efficacy of Three Antimicrobial Agents Used for
Regenerative Endodontics: An In Vitro Study
T2 - MICROBIAL DRUG RESISTANCE
TI - Evaluation of the Efficacy of Three Antimicrobial Agents Used for
Regenerative Endodontics: An In Vitro Study
VL - 25
Y2 - 6 y3 - 1
ID - 15903
ER -
TY - JOUR
AB - Objective(s): Periodontal diseases are among prevalent oral health problems
which may ultimately lead to severe complications in oral cavity. Herbal products
can be designed as single or multicomponent preparations for better oral health.
This study aims to review current clinical trials on the effectiveness of herbal
products in gingivitis. Materials and Methods: Electronic databases, including Pub
Med, Scopus, Science Direct and Cochrane library were searched with the keywords
“gingivitis” in the title/abstract and “plant/ extract/ herb” in the whole text for
clinical trials on herbal treatments for gingivitis. Data were collected from 2000
until January 2018. Only papers with English full-texts were included in our study.
Results: Herbal medicines in the form of dentifrice, mouth rinse, gel, and gum were
assessed in gingivitis via specific indices including plaque index, bleeding index,
microbial count, and biomarkers of inflammation. Pomegranate, aloe, green tea, and
miswak have a large body of evidence supporting their effectiveness in gingivitis.
They could act via several mechanisms such as decrease in gingival inflammation and
bleeding, inhibition of dental plaque formation, and improvement in different
indices of oral hygiene. Some polyherbal formulations such as triphala were also
significantly effective in managing gingivitis complications. Conclusion: Our study
supports the efficacy and safety of several medicinal plants for gingivitis;
however, some plants do not have enough evidence due to the few number of clinical
trials. Thus, future studies are mandatory for further confirmation of the efficacy
of these medicinal plants.
AN - rayyan-563560238
AU - Safiaghdam, H.
AU - Oveissi, V.
AU - Bahramsoltani, R.
AU - Farzaei, M. H.
AU - Rahimi, R.
DO - 10.22038/ijbms.2018.31997.7690
IS - 10
KW - camphor
carotenoid
caryophyllene
chlorhexidine
coumarin
essential oil
flavonoid
gamma interferon
interleukin 1beta
interleukin 2
linalool
menthol
methylxanthine
mouthwash
para cymene
phytochemical
quinone derivative
terpenoid
thymol
toothpaste
Aloe
Azadirachta indica
Calendula officinalis
Camellia sinensis
Curcuma longa
dental scaling
gel
gingivitis
health
human
mouth cavity
Ocimum
periodontal disease
plaque index
pomegranate
review
tea
LA - English
PY - 2018
SN - ["2008-3874", "2008-3866"]
SP - 978-991
ST - Medicinal plants for gingivitis: A review of clinical trials
T2 - Iran. J. Basic Med. Sci.
TI - Medicinal plants for gingivitis: A review of clinical trials
VL - 21
ID - 13612
ER -
TY - JOUR
AN - rayyan-563561748
AU - Sah, A. K.
AU - Dewangan, M.
AU - Suresh, P. K.
DO - 10.1016/j.colsurfb.2019.02.044
PY - 2019
SP - 185-198
ST - Potential of chitosan-based carrier for periodontal drug delivery
T2 - Colloids and Surfaces B: Biointerfaces
TI - Potential of chitosan-based carrier for periodontal drug delivery
85062554442&doi=10.1016%2fj.colsurfb.2019.02.044&partnerID=40&md5=6b21d0bba8879fa9e
4fd9af322f400f1
VL - 178
ID - 15122
ER -
TY - JOUR
AN - rayyan-563562002
AU - Şahin, S.
AU - Saygun, I.
AU - Kurt, B.
AU - Çanakçi, F. C.
AU - Akyol, M.
AU - Altuǧ, H. A.
AU - Kurtiş, B.
AU - Şençimen, M.
IS - 1
PY - 2009
SP - 27-33
ST - The histomorphometrical evaluation of the effects of local antimicrobial
agents in the healing of the tissue defect in the graft area obtained from the
palatinal region
T2 - Gulhane Medical Journal
TI - The histomorphometrical evaluation of the effects of local antimicrobial
agents in the healing of the tissue defect in the graft area obtained from the
palatinal region
69249201253&partnerID=40&md5=722fbb6bad888d4918b73c6d9c78343a
VL - 51
ID - 15376
ER -
TY - JOUR
AB - OBJECTIVES: Polyvinylpyrrolidone-iodine (PVP-iodine or povidone- iodine)
enhances the treatment outcomes of initial periodontal treatment but the degree of
benefit varies in the literature. A main reason might be the concentration of the
dosage form and its contact time with the periodontal tissues. In this randomized
pilot study the effect of repeated subgingival application of PVP-iodine during
scaling and root planing (SRP) was assessed. Changes of clinical parameters and
microbiotic taxa after 3 months were analyzed. METHOD AND MATERIALS: In a split-
mouth design 12 patients with generalized, severe periodontitis were treated with
SRP combined with subgingival application of either PVP-iodine or water. Test and
control sides were isolated with a special rubber dam technique. Irrigations were
reapplied during SRP. Periodontal probing depth (PD) and recessions were documented
before treatment and after 3 months. Samples of subgingival bacteria before SRP and
after 1 week, 1 month, and 3 months were analyzed. RESULTS: Three months after SRP,
changes for PD and recession in deep pockets were significantly higher in the PVP-
iodine group (P = .012 and .044 respectively). The number of these pockets was
reduced from 73 at baseline to 8 in the test and 19 in the control group. In both
groups, bacterial taxa were reduced after 1 week. One month after SRP only taxa of
Porphyromonas gingivalis in the PVP-iodine group were lower than at baseline. After
3 months, all taxa regained baseline values. CONCLUSION: PVP-iodine reapplied
frequently during SRP might enhance pocket depth reduction in initially deep
pockets.
AN - rayyan-563560429
AU - Sahrmann, P.
AU - Imfeld, T.
AU - Ronay, V.
AU - Attin, T.
DO - 10.3290/j.qi.a31341
IS - 4
KW - povidone iodine
adult
controlled study
debridement
female
human
male
middle aged
periodontitis
pilot study
ultrasound
LA - English
PY - 2014
SN - 1936-7163
SP - 281-290
ST - Povidone-iodine gel and solution as adjunct to ultrasonic debridement in
nonsurgical periodontitis treatment: an RCT pilot study
TI - Povidone-iodine gel and solution as adjunct to ultrasonic debridement in
nonsurgical periodontitis treatment: an RCT pilot study
VL - 45
ID - 13803
ER -
TY - JOUR
AB - The aim of the study was to investigate the clearance of PVP-iodine applied
as a gel or solution in periodontal pockets. Teeth of 12 subjects with at least
eight periodontal pockets of ≥5 mm probing depth were isolated with a rubber dam to
allow contamination-free access to the pockets. In each subject, three pockets were
filled with PVP-iodine gel (10%) and three with PVP-iodine solution (10%). One
pocket of each subject without iodine application served as a negative control. The
treatment allocation was assigned randomly. Any excess material was removed
subsequently. After 1, 5 and 15 min, a paper point was used to collect the sulcus
liquid and the concentration of PVP-iodine was chemically determined. In addition,
PVP-iodine gel was administered into 12 periodontal pockets immediately after sub-
gingival ultrasound debridement and the concentration of PVP-iodine was determined
after 1 min. Descending concentrations of PVP-iodine were determined at 1, 5 and 15
min after the application. No PVP-iodine was found in the pockets serving as
negative controls. The mean concentrations of the gel and solution were 6.14 μg/ml
and 4.44 μg/ml (1 min; p ≥ 0.028), 3.20 μg/ml and 1.44 μg/ml (5 min; p ≥ 0.126),
0.69 μg/ml and 0.23 μg/ml (15 min; p ≤ 0.019), respectively. In the pockets with
previous debridement the mean concentration was 1.68 ± 1.97 μg/ml. The application
of PVP-iodine gel in periodontal pockets allows a prolonged remnant effect as
compared to that of the solution formula.
AN - rayyan-563560516
AU - Sahrmann, P.
AU - Sener, B.
AU - Ronay, V.
AU - Attin, T.
IS - 6
KW - povidone iodine
article
female
gel
human
male
periodontitis
LA - English
PY - 2012
SN - 1502-3850
SP - 497-503
ST - Clearance of topically-applied PVP-iodine as a solution or gel in periodontal
pockets in men
TI - Clearance of topically-applied PVP-iodine as a solution or gel in periodontal
pockets in men
VL - 70
ID - 13890
ER -
TY - JOUR
AB - Dental caries is the microbial infectious disease. In recent years it is the
most comment health problem in the world. Toothpaste is a paste or gel dentifrices
used with a tooth brush to promote oral hygiene. Tooth paste cleans the teeth
protects them against tooth decay and keeps them looking healthy and attractive to
look at also ensuring fresh breath. Brushing the teeth is only effective if using
toothpaste as well.
AN - rayyan-563560171
AU - Sahu, B.
AU - Mohanty, R.
DO - 10.5958/0976-5506.2019.03700.8
IS - 11
KW - ascorbic acid
calcium
dental material
desensitizing agent
fluoride
humectant
peppermint
retinol
toothpaste
turmeric
zinc
Aloe vera
article
Artocarpus heterophyllus
banana
cardamom
clove
dental caries
fruit peel
gingivitis
halitosis
herbal medicine
human
Lamiaceae
lemon
mango
mouth cavity
mouth hygiene
orange (fruit)
papaya
squash
tooth brushing
tooth disease
tooth plaque
LA - English
PY - 2019
SN - ["0976-5506", "0976-0245"]
SP - 1283-1286
ST - Herbal toothpaste: A comprehensive overview
TI - Herbal toothpaste: A comprehensive overview
VL - 10
ID - 13545
ER -
TY - JOUR
AB - Periodontal regenerative treatment is useful for intrabony defects and
furcation involvement, but is difficult when there is insufficient keratinized
mucosa to cover and maintain the regenerative material, particularly in the
mandibular molar region. We report the case of a 27-year-old woman who underwent a
two-stage surgical approach for a class II furcation defect with gingival recession
and insufficient keratinized mucosal width (KMW) and vestibular depth at the
mandibular left first molar. We first improved the KMW and keratinized mucosal
thickness using an epithelial embossed connective tissue graft with enamel matrix
derivative, and then focused on periodontal regeneration at the furcation defect
using an enamel matrix derivative and a bovine-derived xenograft. Probing depth
reduction, clinical attachment gain, horizontal probing depth reduction, KMW gain,
and gingival recession reduction were observed 3 years postoperatively. This case
report suggests that this novel staged approach may be effective for treating
furcation defects with insufficient keratinized mucosa, thus providing useful
insights into periodontal regeneration therapy.
AN - rayyan-563560046
AU - Saida, H.
AU - Fukuba, S.
AU - Shiba, T.
AU - Komatsu, K.
AU - Iwata, T.
AU - Nitta, H.
DO - 10.1177/03000605211044595
IS - 9
KW - cardiotocograph
amoxicillin
synthetic bone graft
chlorhexidine
edetic acid
emdogain
enamel protein
gel
polyglactin
prefgel
resin
article
bleeding on probing
bone radiography
cardiotocography
extract digital cardiotocography
follow up
gingiva disease
granulation tissue
jaw malformation
keratinized tissue width
osteolysis
patient compliance
periodontal disease
periodontitis
postoperative care
tissue graft
tooth filling
tooth pain
xenograft
biooss
LA - English
PY - 2021
SN - ["1473-2300", "0300-0605"]
ST - Two-stage approach for class II mandibular furcation defect with insufficient
keratinized mucosa: a case report with 3 years’ follow-up
T2 - J. Int. Med. Res.
TI - Two-stage approach for class II mandibular furcation defect with insufficient
keratinized mucosa: a case report with 3 years’ follow-up
VL - 49
ID - 13420
ER -
TY - JOUR
AB - Among dental diseases, periodontal diseases dominate in their intensity,
prevalence and devastating consequences for the dentition of the person. In this
regard, the search for effective methods for the diagnosis, treatment and
prevention of inflammatory periodontal diseases remains urgent. Recent studies have
allowed to expand and complement the modern view in the regulation of many
physiological processes of the body. Periodontal diseases are no exception. It is
well known that in the complex treatment of periodontal diseases, dentists use a
wide arsenal of medications that affect both the microflora of periodontal pockets
and various mechanisms of the pathogenesis of the inflammatory process. However,
modern methods and tools do not fully justify their clinical effectiveness. In this
regard, an integrated approach to the treatment of gingivitis is gaining increasing
recognition in dental practice. Aim:To study the causes of hypertrophic gingivitis
in adolescence, find optimal treatment options, introduce new methods in the
treatment algorithm. Material and research methods. The study used material (oral
fluid, gingival blood) obtained from 50 patients aged 12-18 years with a diagnosis
of moderate hypertrophic gingivitis and 20 healthy individuals. Depending on the
treatment and preventive measures taken, all patients were divided into 2 groups of
25 people each. In the 1st control group for treatment, traditional antiseptic
treatment of the oral cavity was used using a 0.05% solution of
chlorhexidinebigluconate and periodontal pockets were injected with a metrogel dent
gel under a bandage in the amount of 10 g for 5-7 days. In the 2nd group (n = 25),
patients underwent anti-microbial, topically anti-inflammatory and decongestant
therapy. Traumeel C 301.5 mg in the form of a paste was injected into the
interdental space under a dressing in the amount of 10 g for 5-7 days. The 2nd
group was taken as the main one. The clinical condition of periodontal tissues was
evaluated using the following indices: Hygienic (Green-Wermillion), PI (Russel).
The state of immune resistance of the oral cavity was evaluated using cytological
methods (determination of the content of cellular elements in the liquid of the
periodontal pocket); assessment of the absorption activity of neutrophilic
leukocytes by calculating the phagocytic number during the induction of
phagocytosis by latex particles, as well as the test of spontaneous reduction of
nitro blue tetrazolium (HCT test). Statistical data processing was performed on a
PVEM using MS Excel 10.0 tools. Results.When examining patients, hyperemia of the
gingival mucosa, swelling, loose consistency, bleeding, a small amount of supra and
subgingival tartar, profuse soft plaque, false pockets up to 5 mm with serous
exudate, papillae enlarged and deformed, hypertrophy up to 1/2 were determined the
length of the crown of the teeth, the average value of the clinical indices was IG
- 2.58 ± 0.5 and PI - 5.5 ± 0.4. After completion of the course of therapy,
improvement was noted in patients of all groups: Tightening of the gingival margin,
decreased bleeding, disappearance of false pockets. The positive dynamics of
changes in the index indicators of the periodontal condition was noted. The highest
results were achieved in the 2nd group, where the value of the PI indicator from
2.58 ± 0.5 points to 0.14 ± 0.1, PI from 5.5 ± 0.4 to 2.56 ± 0.8 (p <0.05).
Conclusion. Thus, the effectiveness of the local use of the drug "Traumeel C" is
confirmed by the results of clinical and laboratory studies.
AN - rayyan-563560101
AU - Saidova, N. A.
IS - 3
cytokine
decongestive agent
latex
metronidazole
adolescent
adult
article
bleeding
child
controlled study
gingivitis
human
hyperemia
hypertrophy
immunity
mouth cavity
neutrophil
periodontal pocket
phagocytosis
swelling
LA - English
PY - 2020
SN - 2515-8260
SP - 3749-3756
ST - Results ofintegrated treatment of hypertrophic gingivitis in adolescents
TI - Results ofintegrated treatment of hypertrophic gingivitis in adolescents
VL - 7
ID - 13475
ER -
TY - JOUR
AB - The excessive production of reactive oxygen species (ROS) has been implicated
in a variety of disorders, but to date, ROS scavengers have not been widely used
for local treatment of inflammation, because they are rapidly eliminated from the
inflamed site. We have designed a novel redox injectable gel (RIG) that is formed
at 37 °C after disintegration of nano-assembled flower micelles allowing nitroxide
radicals to act locally as specific ROS scavengers for the treatment of
periodontitis. In the present study, we have confirmed retention of the RIG in the
periodontal region, along with its antioxidant-related anti-inflammatory effects,
and we have subsequently evaluated the inhibitory effect of the RIG against
Porphyromonas gingivalis (P. gingivalis)-induced alveolar bone loss attributed to
ROS. Alveolar bone loss was estimated by morphometry, gingival blood flow was
measured using laser Doppler flowmetry, and osteoclast differentiation was
evaluated by tartrate-resistant acid phosphatase staining. The results show that
the RIG can inhibit P. gingivalis-induced bone loss by antioxidant-related anti-
inflammatory actions, and this suggests that the RIG is a promising novel
therapeutic agent for the treatment of P. gingivalis-induced periodontitis.
AN - rayyan-563560362
AU - Saita, M.
AU - Kaneko, J.
AU - Sato, T.
AU - Takahashi, S. S.
AU - Wada-Takahashi, S.
AU - Kawamata, R.
AU - Sakurai, T.
AU - Lee, M. C. I.
AU - Hamada, N.
AU - Kimoto, K.
AU - Nagasaki, Y.
DO - 10.1016/j.biomaterials.2015.10.077
KW - acid phosphatase tartrate resistant isoenzyme
antioxidant
interleukin 1beta
interleukin 6
malonaldehyde
nitroxide
redox injectable gel
unclassified drug
alveolar bone
alveolar bone loss
animal cell
animal experiment
animal model
animal tissue
article
blood flow
controlled study
laser Doppler flowmetry
male
micelle
morphometry
nonhuman
osteoclast
osteoclastogenesis
osteolysis
priority journal
rat
LA - English
PY - 2016
SN - ["1878-5905", "0142-9612"]
SP - 292-301
ST - Novel antioxidative nanotherapeutics in a rat periodontitis model: Reactive
oxygen species scavenging by redox injectable gel suppresses alveolar bone
resorption
T2 - Biomaterials
TI - Novel antioxidative nanotherapeutics in a rat periodontitis model: Reactive
oxygen species scavenging by redox injectable gel suppresses alveolar bone
resorption
VL - 76
ID - 13736
ER -
TY - JOUR
AB - Controlled-release metronidazole, mucoadhesive gel proposed as a drug-
delivery system for periodontal application was developed and characterized. The
system was based on a mixture of glycerylmonooleate (GMO) and ethylcellulose (EC).
The mechanism of release depends: firstly, on the ability of GMO to form a viscous
liquid crystalline mesophases and secondly on the solubilized EC to form a
hydrophobic network when the mixture comes into contact with water resulting in
sustaining the release of the drug. Ethylcellulose dissolved in GMO had a profound
influence on the rate of drug release, reduced the initial drug release and
prolonged the sustained release of metronidazole. Propylene glycol (PG) was added
to increase the solubility of the drug and water was added with PG to control the
viscosity. A controlled release formulation containing w/w, 20% metronidazole, 10%
PG, 5% water and 65% GMO that contains 7% EC was found to be mucoadhesive, easily
injectable at room temperature, and to follow Fickian diffusion release mechanism.
When the drug loading was increased the drug release was accelerated, and the
mechanism followed anomalous controlled-release mechanism. Stability studies
indicated that the formulation should be stored at 4°C in a dark place.
AN - rayyan-563560394
AU - Sallam, A. S.
AU - Hamudi, F. F.
AU - Khalil, E. A.
DO - 10.3109/10837450.2013.852573
IS - 2
KW - ethyl cellulose
glycerol oleate
metronidazole
propylene glycol
article
drug diffusion
drug solubility
gel
priority journal
room temperature
viscosity
LA - English
PY - 2015
SN - ["1097-9867", "1083-7450"]
SP - 159-168
ST - Effect of ethylcellulose and propylene glycol on the controlled-release
performance of glyceryl monooleate-mertronidazole periodontal gel
TI - Effect of ethylcellulose and propylene glycol on the controlled-release
performance of glyceryl monooleate-mertronidazole periodontal gel
VL - 20
ID - 13768
ER -
TY - JOUR
AB - Purpose: To evaluate the influence of tetracycline gel, brushed on tooth
surfaces, on penodontal clinical parameters following root debridement. Methods: 20
subjects diagnosed with chronic periodontitis and presenting a minimum of two
proximal sites on anterior teeth (maxillary or mandibular) with probing depth ± 5
mm, were selected. Following oral hygiene instructions and ultrasonic supragingival
instrumentation, subjects were assigned to one of the following groups: RDS - root
debridement with Gracey curettes and root brushing with saline solution; and RDT -
root debridement with Gracey curettes and root brushing with 40% tetracycline gel.
Full-thickness flaps were reflected and instrumentation was performed using a
clinical microscope to optimize calculus detection. Probing depth (PD), relative
gingival margin level (RGML) and relative attachment level (RAL) measures were
registered at five visits: baseline and days 30, 60, 90 and 120 postoperative.
Results: Both approaches were able to markedly reduce the PD values from baseline
in all periods (P< 0.0001). No differences were found for RAL values in any of the
groups. No differences were found between groups. In conclusion, the application of
tetracycline gel does not seem to provide any additional improvement on clinical
periodontal parameters after root debridement.
AN - rayyan-563560701
AU - Sallum, A. W.
AU - Alves, R. V.
AU - Damis, L. F. T.
AU - Bertolini, P. F. R.
AU - Nociti Jr, F. H.
AU - Sallum, E. A.
IS - 3
tetracycline
adult
article
clinical trial
comparative study
controlled study
drug effect
female
follow up
gel
gingiva disease
human
male
middle aged
mouth hygiene
pathology
periodontal disease
periodontal pocket
periodontics
periodontitis
plastic surgery
tooth root
ultrasound therapy
LA - English
PY - 2008
SN - 0894-8275
SP - 168-170
ST - Tetracycline gel as an adjunct to surgical root debridement
T2 - Am. J. Dent.
TI - Tetracycline gel as an adjunct to surgical root debridement
VL - 21
ID - 14075
ER -
TY - JOUR
AB - The objective was to review the literature on the effects of selective and
non-selective non-steroidal anti-inflammatory drugs (NSAIDs) on the treatment of
periodontal diseases. A search of MEDLINE was conducted and articles published in
English until December 2003 were included. The results from in vitro and animal
experiments as well as from human clinical trials are presented. Non-selective
cyclooxygenase-1 (COX-1) inhibitors used in periodontal research include compounds
such as aspirin, flurbiprofen, ibuprofen, naproxen and piroxicam. Selective
cyclooxygenase-2 (COX-2) inhibitors represent a new group of pharmaceutical
products termed "coxibs" that include meloxicam, nimesulide, etodolac and
celecoxib. Evidence from animal experiments and clinical trials documents that
selective and non-selective NSAIDs are mainly responsible for the stabilization of
periodontal conditions by reducing the rate of alveolar bone resorption. This is
achieved through local inhibition of both enzymes (e.g. COX-1 and COX-2)
responsible for the synthesis of arachidonic acid metabolites. Evidence shows that
the effects of NSAIDs drop off rapidly after drugwithdrawal. One of the major
advantages of selective COX-2 inhibition is the reduction of adverse systemic
effects. Although some studies present promising results, no data from long-term,
multicenter prospective clinical trials are yet available for determining whether
these therapeutic effects can be retained on a long-term basis. Many of these
compounds, such as flurbiprofen, are readily absorbed through the gingival tissues.
Therefore, the development of topical NSAIDs formulations (e.g. gels, toothpastes,
rinses) with a daily application seems to be of particular interest. This may help
to further reduce adverse systemic effects of non-selective NSAIDs in the long-term
host modulation of periodontitis-susceptible patients. © 2005 Bentham Science
Publishers Ltd.
AN - rayyan-563560843
AU - Salvi, G. E.
AU - Lang, N. P.
DO - 10.2174/1381612053764878
IS - 14
KW - acetylsalicylic acid
arachidonic acid
calcitonin
celecoxib
cyclooxygenase 1
cyclooxygenase 2
etodolac
flurbiprofen
ibuprofen
indometacin
ketoprofen
ketorolac trometamol
meclofenamate sodium
meclofenamic acid
meloxicam
naproxen
nimesulide
piroxicam
placebo
prostaglandin E2
prostaglandin F2
pyridine derivative
sulindac
tetracycline
toothpaste
alveolar bone
arachidonic acid metabolism
clinical trial
dog
drug absorption
drug blood level
drug effect
drug selectivity
drug withdrawal
enzyme inhibition
enzyme synthesis
evidence based medicine
gel
gingiva
gingiva bleeding
gingivitis
hamster
human
in vitro study
inhibition kinetics
kidney disease
lavage
medical literature
medical research
Medline
meta analysis
mouth hygiene
nonhuman
oral surgery
osteolysis
pathogenesis
periodontal disease
periodontics
periodontitis
priority journal
review
rhesus monkey
squirrel monkey
stomach ulcer
systematic review
treatment outcome
aspirin
LA - English
PY - 2005
SN - 1381-6128
SP - 1757-1769
ST - The effects of non-steroidal anti-inflammatory drugs (selective and non-
selective) on the treatment of periodontal diseases
T2 - Curr. Pharm. Des.
TI - The effects of non-steroidal anti-inflammatory drugs (selective and non-
selective) on the treatment of periodontal diseases
VL - 11
ID - 14217
ER -
TY - JOUR
AB - AIM: The aim of this single-blind, randomized, parallel-designed clinical
trial (RCT) was to evaluate the clinical and microbiological effects of three
sustained-release biodegradable polymers delivered into periodontal pockets
following initial periodontal therapy. METHODS: Forty-seven patients (28 females
and 19 males) with a mean age of 51 years (range 29-71) underwent a periodontal
examination at baseline (i.e. Week 0) and after 18 weeks. This included the
assessment of the Plaque Index (PlI), Bleeding on Probing (BOP), Pocket Probing
Depths (PPD) and Probing Attachment Levels (PAL) at six sites per tooth. Two to 4
months prior to baseline, all subjects had received initial periodontal therapy
including motivation, instruction in oral hygiene practices and full-mouth scaling
and root planing. At the treatment appointment (i.e. Week 2), the patients were
randomly assigned to receive either Atridox trade mark, Elyzol Dental Gel or
PerioChip at all residual periodontal pockets with a probing depth >/= 5 mm and
concomitant BOP. In accordance with the manufacturer's recommendations, Elyzol
Dental Gel was applied for a second time 7 days later. In addition to the clinical
evaluation, subgingival microbiological samples were collected prior to treatment
(i.e. Week 2) and at Weeks 4 and 18. Analysis of variance/covariance was used to
evaluate changes from baseline to Week 18 for the clinical parameters. RESULTS:
Between the baseline and 18-week examinations, subjects treated with Atridox showed
a significantly greater gain in mean PAL of 0.33 mm +/- 0.09 (SD) than subjects
treated with Elyzol Dental Gel [0.03 mm +/- 0.09 (SD)](p = 0.03). However, the gain
in PAL of 0.16 mm +/- 0.10 (SD) found after PerioChip application did not differ
significantly from that obtained following the application of Atridox(p = 0.27). Of
the sites treated with Atridox, 42% gained >/= 1 mm PAL and 9% >/= 2 mm PAL as
opposed to the sites treated with Elyzol Dental Gel, in which 34% gained >/= 1 mm
PAL and 8% gained >/= 2 mm PAL. Of the sites treated with PerioChip, 36% gained >/=
1 mm and 6% gained >/= 2 mm PAL following a completed initial periodontal therapy.
CONCLUSIONS: The application of the three biodegradable sustained release devices
tested following initial periodontal therapy resulted in a statistically
significant gain in mean PAL for AtridoxTM and a significant reduction in PPD for
all three devices during the study period. Furthermore, when sites treated with
Atridox were compared with sites treated with Elyzol, a significant difference in
mean PAL gain (0.3 mm) was observed.
AN - rayyan-563560903
AU - Salvi, G. E.
AU - Mombelli, A.
AU - Mayfield, L.
AU - Rutar, A.
AU - Suvan, J.
AU - Garrett, S.
AU - Lang, N. P.
IS - 6
KW - acylglycerol
antiinfective agent
chlorhexidine
doxycycline
doxycycline hyclate
drug derivative
Elyzol Dentalgel
metronidazole
sesame seed oil
adult
aged
article
bacterial count
bioremediation
clinical trial
comparative study
controlled study
female
follow up
Fusobacterium
gingiva bleeding
human
male
microbiology
middle aged
periodontal disease
periodontitis
Porphyromonas
Prevotella
tooth plaque
treatment outcome
LA - English
PY - 2002
SN - 0303-6979
SP - 540-550
ST - Local antimicrobial therapy after initial periodontal treatment
TI - Local antimicrobial therapy after initial periodontal treatment
VL - 29
ID - 14277
ER -
TY - JOUR
AB - Aim: The aim of this single-blind, randomized, parallel-designed clinical
trial (RCT) was to evaluate the clinical and microbiological effects of three
sustained-release biodegradable polymers delivered into periodontal pockets
following initial periodontal therapy. Methods: Forty-seven patients (28 females
and 19 males) with a mean age of 51 years (range 29-71) underwent a periodontal
examination at baseline (i.e. Week 0) and after 18 weeks. This included the
assessment of the Plaque Index (PlI), Bleeding on Probing (BOP), Pocket Probing
Depths (PPD) and Probing Attachment Levels (PAL) at six sites per tooth. Two to 4
months prior to baseline, all subjects had received initial periodontal therapy
including motivation, instruction in oral hygiene practices and full-mouth scaling
and root planing. At the treatment appointment (i.e. Week 2), the patients were
randomly assigned to receive either Atridox(TM), Elyzol(R) Dental Gel or
PerioChip(R) at all residual periodontal pockets with a probing depth greater than
or equal to 5 mm and concomitant BOP. In accordance with the manufacturer's
recommendations, Elyzol(R) Dental Gel was applied for a second time 7 days later.
In addition to the clinical evaluation, subgingival microbiological samples were
collected prior to treatment (i.e. Week 2) and at Weeks 4 and 18. Analysis of
variance/covariance was used to evaluate changes from baseline to Week 18 for the
clinical parameters. Results: Between the baseline and 18-week examinations,
subjects treated with Atridox showed a significantly greater gain in mean PAL of
0.33 mm +/- 0.09 (SD) than subjects treated with Elyzol(R) Dental Gel [0.03 mm +/-
0.09 (SD)](p=0.03). However, the gain in PAL of 0.16 mm +/- 0.10 (SD) found after
PerioChip(R) application did not differ significantly from that obtained following
the application of Atridox(TM) (p=0.27). Of the sites treated with Atridox(TM) ,
42% gained greater than or equal to 1 mm PAL and 9% greater than or equal to 2 mm
PAL as opposed to the sites treated with Elyzol(R) Dental Gel, in which 34% gained
greater than or equal to 1 mm PAL and 8% gained greater than or equal to 2 mm PAL.
Of the sites treated with PerioChip(R), 36% gained greater than or equal to 1 mm
and 6% gained greater than or equal to 2 mm PAL following a completed initial
periodontal therapy. Conclusions: The application of the three biodegradable
sustained release devices tested following initial periodontal therapy resulted in
a statistically significant gain in mean PAL for Atridox(TM) and a significant
reduction in PPD for all three devices during the study period. Furthermore, when
sites treated with Atridox(TM) were compared with sites treated with Elyzol(R) , a
significant difference in mean PAL gain (0.3 mm) was observed.
AN - rayyan-563562288
AU - Salvi, G. E.
AU - Mombelli, A.
AU - Mayfield, L.
AU - Rutar, A.
AU - Suvan, J.
AU - Garrett, S.
AU - Lang, N. P.
DO - 10.1034/j.1600-051X.2002.290611.x
IS - 6
PY - 2002
SN - ["0303-6979", "1600-051X"]
SP - 540-550
ST - Local antimicrobial therapy after initial periodontal treatment - A
randomized clinical trial comparing three biodegradable sustained release polymers
TI - Local antimicrobial therapy after initial periodontal treatment - A
randomized clinical trial comparing three biodegradable sustained release polymers
VL - 29
Y2 - 6
ID - 15662
ER -
TY - JOUR
AN - rayyan-563561969
AU - Salvi, G. E.
AU - Mombelli, A.
AU - Mayfield, L.
AU - Rutar, A.
AU - Suvan, J.
AU - Garrett, S.
AU - Lang, N. P.
DO - 10.1034/j.1600-051X.2002.290611.x
IS - 6
PY - 2002
SP - 540-550
ST - Local antimicrobial therapy after initial periodontal treatment: A randomized
clinical trial comparing three biodegradable sustained release polymers
TI - Local antimicrobial therapy after initial periodontal treatment: A randomized
clinical trial comparing three biodegradable sustained release polymers
0036598367&doi=10.1034%2fj.1600-
051X.2002.290611.x&partnerID=40&md5=25cc6f0344761e5ecce8acf545c13396
VL - 29
ID - 15343
ER -
TY - JOUR
AB - Aim: To monitor over 12 months clinical and radiographic changes occurring
after adjunctive local delivery of minocycline microspheres for the treatment of
peri-implantitis. Material and methods: In 25 partially edentulous subjects, 31
implants diagnosed with peri-implantitis were treated. Three weeks after oral
hygiene instruction, mechanical debridement and local antiseptic cleansing using
0.2% chlorhexidine gel, baseline (Day 0) parameters were recorded. Minocycline
microspheres (Arestin (R)) were locally delivered to each implant site with bone
loss and a probing pocket depth (PPD) >= 5 mm. Rescue therapy with Arestin (R) was
allowed at Days 180 and 270 at any site exhibiting an increase in PPD >= 2 mm from
the previous visit. The following clinical parameters were recorded at four
sites/implant at Day 0, 10, 30, 60, 90, 180, 270 and 360: PPD, clinical attachment
level (CAL), bleeding on probing (BOP) and plaque index (PII). Results: Six
implants in six subjects were either rescued or exited because of persisting active
peri-implantitis. Successful implants showed a statistically significant reduction
in both PPD and percentage of sites with BOP between baseline and Day 360 (P <
0.05). At mesial implant sites, the mean PPD reduction amounted to 1.6 mm (95% CI:
0.9-2.2 mm, P < 0.001) and was accompanied by a statistically significant reduction
of the BOP value (P < 0.001). Binary regression analysis showed that the clinical
parameters and smoking history could not discriminate between successfully treated
and rescued or exited implants at any observation time point. Conclusion: Non-
surgical mechanical treatment of peri-implantitis lesions with adjunctive local
delivery of microencapsulated minocycline led to positive effects on clinical
parameters up to 12 months.
AN - rayyan-563562640
AU - Salvi, G. E.
AU - Persson, G. R.
AU - Frei, M.
AU - Lang, N. P.
DO - 10.1111/j.1600-0501.2007.01377.x
IS - 3
PY - 2007
SN - ["0905-7161", "1600-0501"]
SP - 281-285
ST - Adjunctive local antibiotic therapy in the treatment of peri-implantitis -
II: clinical and radiographic outcomes
T2 - CLINICAL ORAL IMPLANTS RESEARCH
TI - Adjunctive local antibiotic therapy in the treatment of peri-implantitis -
II: clinical and radiographic outcomes
VL - 18
Y2 - 6
ID - 16014
ER -
TY - JOUR
AB - Periodontitis is one of the most widespread oral inflammatory infectious
diseases affecting the oral cavity. This study aims to develop and characterize a
more effective syringeable curcumin in situ gel for the treatment of periodontitis
and evaluate its clinical effectiveness. Curcumin in situ gel was formulated by the
cold method using temperature-sensitive (Poloxamer 188, 407), pH-sensitive
(Carbopol 934P), and ion-sensitive (Gellan gum) polymers. Gel formulations
including Poloxamer 407 and Carbopol 934P as independent factors for the selected
response like viscosity and gelation temperature were optimized using central
composite design (CCD). All the formulation evaluations were made to ascertain drug
content, gelation temperature, viscosity, stability, and in vitro drug release.
Appropriate physical characteristics for most formulations and their suitability
for periodontitis were observed. Appropriate gelation temperature was found to
range from 30.2 to 36.5 oC, with a pH of 6.14 to 7.25. The viscosity of the gel at
4 oC ranged from 12540 to 32400 centipoise. In all cases, the designed formulations
were found to be successfully syringeable with a 21-gauge needle at cold
temperature. Most of the formulations showed a greater correlation with the Higuchi
equation, supporting the assumption that diffusion was the primary mechanism of
drug release. Clinical study of the optimized gel formulation revealed a
substantial reduction in the clinical markers of periodontitis. The study shows
that curcumin in situ gel may be considered as a promising delivery mode for the
safe and efficient treatment of periodontitis which substantially overcomes the
drawbacks of conventional therapy.
AN - rayyan-563559797
AU - Samal, H. B.
AU - Boyeena, L.
AU - Patra, N. Ch
AU - Sriram, S.
AU - Das, I. J.
DO - 10.53879/id.59.11.13253
IS - 11
KW - dental needle
carbomer
curcumin
gel
gellan
macrogol
methyl paraben
poloxamer
polymer
adult
article
clinical article
clinical assessment
clinical evaluation
cold
controlled study
dental scaling
drug formulation
drug stability
experimental design
gelation
human
in vitro study
nonhuman
pH
root planing
study
surface analysis
viscometry
viscosity
LA - English
PY - 2022
SN - 0019-462X
SP - 21-36
ST - CURCUMIN IN SITU GEL FOR LOCAL TREATMENT OF PERIODONTITIS: PREPARATION, IN
VITRO EVALUATION AND CLINICAL ASSESSMENT
T2 - Indian Drugs
TI - CURCUMIN IN SITU GEL FOR LOCAL TREATMENT OF PERIODONTITIS: PREPARATION, IN
VITRO EVALUATION AND CLINICAL ASSESSMENT
VL - 59
ID - 13171
ER -
TY - JOUR
AB - Periodontitis describes a group of related inflammatory diseases resulting in
the destruction of the tissues that support the tooth. This disease results from
the growth of diverse microflora (especially anaerobes) in the periodontal pockets
and releases various bacterial enzymes, toxins, and stimulation of the body’s
immune response. Scaling and Root planning is the basic treatment modality for
periodontitis. Mechanical treatment is limited by physical impediments and
biochemical considerations. Antimicrobial agents may be used as an adjunct to
overcome the limitations of mechanical therapy. Nonsurgical controlled intrapocket
delivery of antimicrobials in the treatment of periodontitis has been investigated
for the possibility of overcoming the limitations of conventional therapy.
Nonsurgical controlled release formulations to deliver antibacterial to the site of
periodontal pocket are designed to be of low cost, nontoxic, biocompatible,
biodegradable, greater stability, non-immunogenicity, and effective long-term
treatment at the site of infection with reduced systemic dosing. A number of
polymer based delivery systems like fibers, strips, films, chips, microparticles,
nanoparticles, and nanofiber made from a variety of natural and synthetic materials
have been successfully tested to deliver a variety of drugs. Periodontal pockets as
a drug delivery platform for designing a suitable dental localized dosage form
along with its potential advantage and limitations is reviewed here.
AN - rayyan-563560020
AU - Samal, H. B.
AU - Niranjan Patra, C.
AU - Boyeena, L.
AU - Das, I. J.
IS - 3
KW - film
antiinfective agent
gel
liposome
microsphere
nanofiber
nanoparticle
chewing gum
human
nonhuman
periodontal pocket
periodontitis
review
tooth disease
treatment contraindication
LA - English
PY - 2021
SN - 0019-462X
SP - 7-21
ST - Novel periodontal pocket drug delivery systems for the treatment of
periodontitis
T2 - Indian Drugs
TI - Novel periodontal pocket drug delivery systems for the treatment of
periodontitis
VL - 58
ID - 13394
ER -
TY - JOUR
AB - INTRODUCTION: The aim of this study was to compare the antibacterial effects
of two gels containing zinc oxide and zinc oxide/silver nanoparticles and a mixture
of calcium hydroxide and 0.12% chlorhexidine as intracanal medicaments in root
canals contaminated with Enterococcus faecalis (E. faecalis) at different time
intervals. METHODS AND MATERIALS: After preparation and culturing of E. faecalis in
132 single root teeth, the initial count of bacteria was performed. Then, different
materials as intracanal medicaments were used in periods of 3, 7 and 14 days (group
1: calcium hydroxide with 0.12% CHX paste; group 2 zinc oxide nanoparticles gel;
group 3: zinc oxide/silver nanoparticles gel; group 4: normal saline as the control
group). After the specified time, intracanal medicament was removed and the final
count of bacteria was performed. Antibacterial effect of materials was counted by
measuring the percentage reduction in the colony counts (RCC). Data were analyzed
using the descriptive statistics (Mean±SD) and multi-factorial analysis of variance
(by taking into account the effect of the time factor on the dependent variable).
RESULTS: There were no statistically significant differences among mean RCC of
different time intervals in each group (P=0.09). However, the differences in mean
RCC of different dressing materials were significant (P<0.001). The effect of
interaction between time and materials was significant (P=0.015). Comparison of the
antibacterial effects of experimental agents at different time intervals showed
that the mean RCC in group 1 was higher than other groups (P<0.001). The difference
in antibacterial effect between groups 2 and 3 was not significant (P>0.05). The
minimum antibacterial effect was observed in group 4 (P<0.0001). CONCLUSIONS: The
mixture of calcium hydroxide/chlorhexidine as an intracanal medicament was more
effective than zinc oxide and zinc oxide/silver nanoparticles gels.
AN - rayyan-563560970
AU - Samiei, M.
AU - Torab, A.
AU - Hosseini, O.
AU - Abbasi, T.
AU - Abdollahi, A. A.
AU - Divband, B.
DO - 10.22037/iej.v13i3.19866
IS - 3
J2 - Iran Endod J
LA - eng
N1 - Department of Endodontics, Dental School, Tabriz University of Medical
Sciences, Tabriz, Iran.; Department of Prosthodontics, Dental and Periodontal
Research Center, Dental School, Tabriz University of Medical Sciences, Tabriz,
Iran.; Dental and Periodontal Research Center, Dental School, Tabriz University of
Medical Sciences, Tabriz, Iran.; Dental School Hospital, Tabriz University of
Medical Sciences, Tabriz, Iran.; Department of Endodontics, Dental School, Urmia
University of Medical Sciences, Urmia, Iran.; Drug Applied Research Center, Tabriz
University of Medical Sciences, Tabriz, Iran.
PY - 2018
SN - 1735-7497 (Print)
SP - 305-311
ST - Antibacterial Effect of Two Nano Zinc Oxide Gel Preparations Compared to
Calcium Hydroxide and Chlorhexidine Mixture
TI - Antibacterial Effect of Two Nano Zinc Oxide Gel Preparations Compared to
Calcium Hydroxide and Chlorhexidine Mixture
VL - 13
ID - 14344
ER -
TY - JOUR
AB - There is increasing attention to the potential benefit from the use of
antioxidants in the field of dental medicine. In general, antioxidants may be
available through oral ingestion, diet or vitamin supplements, and in
nutraceuticals. In addition, treatment of oral and dental health problems may
include drug-free, natural antioxidant remedies that are available in topical oral
applications such as mouth rinse, gel, paste, gum, or lozenge compositions. These
topical antioxidant remedies help reduce free-radical or reactive-oxygen species,
which are causative inflammatory factors in the progression of gingival and
periodontal maladies. This review focuses on relationships between antioxidants and
free-radical/reactive-oxygen species in the oral environment.
AN - rayyan-563560611
AU - San Miguel, S. M.
AU - Opperman, L. A.
AU - Allen, E. P.
AU - Svoboda, K. K.
IS - 2
KW - antioxidant
dental procedure
health
human
review
LA - English
PY - 2011
SN - 1548-8578
SP - e25-28
ST - Use of antioxidants in oral healthcare
TI - Use of antioxidants in oral healthcare
VL - 32
ID - 13985
ER -
TY - JOUR
AB - The effect on periodontal healing after guided tissue regeneration (GTR)in
association with local application of metronidazole gel was evaluated in this
study. Twelve patients with one pair of vertical periodontal bone defects of
comparable size and configuration participated in the study. In a matched paired
design, the test defects were treated by GTR using expanded polytetrafluoroethylene
(ePTFE) membranes in combination with local application of metronidazole gel. The
controls were treated in the same way except for application of metronidazole.
During the first month of membrane implantation, no statistically significant
differences between test and control surfaces were noted with respect to
inflammation of the marginal gingiva. Six weeks following insertion, the membranes
were removed. Six months after removal of the membrane, the median gain in probing
attachment level as a percentage of the initial defect depth was 92% for test
defects and 50% for control defects (P = .001). No statistically significant
differences were found between test and control sites regarding plaque, bleeding on
probing, reduction in pocket depth, gain in bone height, or recession of the
gingival margin. In conclusion, the results of the present study indicate that
local application of metronidazole gel has a beneficial effect on healing of
periodontal vertical defects treated by guided tissue regeneration.
AN - rayyan-563561074
AU - Sander, L.
AU - Frandsen, E. V. G.
AU - Arnbjerg, D.
AU - Warrer, K.
AU - Karring, T.
DO - 10.1902/jop.1994.65.10.914
IS - 10
KW - metronidazole
adult
article
clinical article
female
gingiva
human
male
periodontal disease
tissue regeneration
tooth plaque
wound healing
LA - English
PY - 1994
SN - 0022-3492
SP - 914-920
ST - Effect of local metronidazole application on periodontal healing following
guided tissue regeneration. Clinical findings
TI - Effect of local metronidazole application on periodontal healing following
guided tissue regeneration. Clinical findings
VL - 65
ID - 14448
ER -
TY - JOUR
AB - Propolis collected from a cerrado area in Minas Gerais State, Brazil, was
subjected to chromatography on silica gel column and to partition between
immiscible solvents. Propolis aqueous-ethanolic extract and fractions obtained were
tested for inhibitory activity against periodontitis-causing bacteria. All of the
assayed bacterium species were susceptible to propolis extract. The two
fractionation methodologies yielded fractions which were active against bacteria,
with minimum inhibitory concentrations (MIC) ranging from 64 to 1024 μg/ml. TLC and
HPLC analyses of the extract and of active fractions showed the presence of
phenolic compounds of varied polarity. None of the assayed fractions was more
active than the extract, suggesting that the antibacterial activity is probably due
to the synergistic effect of several compounds. © 2002 Elsevier Science Ireland
Ltd. All rights reserved.
AN - rayyan-563560909
AU - Santos, F. A.
AU - Bastos, E. M. A.
AU - Uzeda, M.
AU - Carvalho, M. A. R.
AU - Farias, L. M.
AU - Moreira, E. S. A.
AU - Braga, F. C.
DO - 10.1016/S0378-8741(02)00003-X
IS - 1
KW - phenol derivative
propolis
anaerobic bacterium
bacterial strain
bee extract
Brazil
drug determination
drug potentiation
fractionation
human
mouth flora
nonhuman
periodontitis
review
LA - English
PY - 2002
SN - 0378-8741
SP - 1-7
ST - Antibacterial activity of Brazilian propolis and fractions against oral
anaerobic bacteria
TI - Antibacterial activity of Brazilian propolis and fractions against oral
anaerobic bacteria
VL - 80
ID - 14283
ER -
TY - JOUR
AB - Propolis collected from a cerrado area in Minas Gerais State, Brazil, was
subjected to chromatography on silica gel column and to partition between
immiscible solvents. Propolis aqueous-ethanolic extract and fractions obtained were
tested for inhibitory activity against periodontitis-causing bacteria. All of the
assayed bacterium species were susceptible to propolis extract. The two
fractionation methodologies yielded fractions which were active against bacteria,
with minimum inhibitory concentrations (MIC) ranging from 64 to 1024 microg/ml. TLC
and HPLC analyses of the extract and of active fractions showed the presence of
phenolic compounds of varied polarity. None of the assayed fractions was more
active than the extract, suggesting that the antibacterial activity is probably due
to the synergistic effect of several compounds.
AN - rayyan-563561377
AU - Santos, F. A.
AU - Bastos, E. M.
AU - Uzeda, M.
AU - Carvalho, M. A.
AU - Farias, L. M.
AU - Moreira, E. S.
AU - Braga, F. C.
DO - 10.1016/s0378-8741(02)00003-x
IS - 1
J2 - J Ethnopharmacol
KW - Anti-Bacterial Agents/chemistry/*pharmacology
Brazil
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Gram-Negative Anaerobic Bacteria/*drug effects
Gram-Negative Bacterial Infections/*microbiology
Periodontitis/*microbiology
Propolis/chemistry/*pharmacology
Solvents/chemistry
LA - eng
N1 - Departamento de Microbiologia, Laboratório de Biologia de Microrganismos,
Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Caixa
Postal 486, Avenida Antônio Carlos 6627, CEP 31270 901, MG, Belo Horizonte, Brazil.
PY - 2002
SN - 0378-8741 (Print)
SP - 1-7
ST - Antibacterial activity of Brazilian propolis and fractions against oral
anaerobic bacteria
T2 - Journal of ethnopharmacology
TI - Antibacterial activity of Brazilian propolis and fractions against oral
anaerobic bacteria
VL - 80
Y2 - 4
ID - 14751
ER -
TY - JOUR
AB - Introduction: Tooth bleaching is a common procedure in aesthetic dentistry
[1]. Following tooth bleaching, many adhesive procedures are also commonly
performed in order to improve the overall aesthetics, such as anterior direct or
indirect restorations, anatomical recontouring or diastema closure. The bleaching
agents are known to induce alterations on the microhardness, chemical composition
and surface roughness of the tooth structure [2]. Consequently, this has a
detrimental effect on the adhesion of subsequent restorations [3]. Considering
this, it is necessary to research their overall effect on the microtensile bond
strength to enamel. Materials and methods: 13 molars extracted for periodontal or
orthodontic reasons, were longitudinally sectioned into 25 fragments total. The
fragments were randomly distributed into 5 groups (n=5), depending on the
application of the bleaching gel: Group 1 - placebo gel (control); Group 2 - 35%
hydrogen peroxide gel Perfect Bleach Office + (Voco); Group 3 - 37.5% hydrogen
peroxide gel Norblanc Office Automix (Normon); Group 4 - 16% carbamide peroxide gel
Norblanc Home (Normon); Group 5 - 16% carbamide peroxide gel Perfect Bleach (Voco).
The bleaching gels were applied three times within a week between each application.
After the third application, the fragments were restored with composite resin.
After 24 h, the fragments were cut with a diamond saw with slow rotation speed in X
and Y directions in order to obtain sticks with 1 ± 0.2mm2 section. The sticks were
stressed to failure in tension using a universal testing machine at a crosshead
speed of 0.5mm/min. For the statistical analysis, ANOVA one-way and Tukey's HSD
post-hoc tests (α=0.05) (SPSS 20.0) were used. Results: The microtensile bond
strength of the control samples (Group 1) is significantly higher than the samples
treated with gels 2 (p=.006) and 3 (p=.047) and differs significantly from the
samples treated with the gels 4 (p=.087) and 5 (p=.385). The samples treated with
gels 2, 3, 4 and 5 do not differ significantly from each other with regard to
microtensile bond strength (p>.05) in either comparison. Discussion and
conclusions: This in vitro study suggests that there is a reduction in the enamel's
bond strength after bleaching treatment with hydrogen peroxide and carbamide
peroxide gels that can be explained by the presence of residual oxygen in the
enamel after tooth bleaching which may inhibit the adhesive and composite resin
complete polymerization.
AN - rayyan-563560272
AU - Santos, I. C.
AU - Delgado, A. H. S.
AU - Silva, N.
AU - Brito, J.
AU - Polido, M.
AU - Mendes, J. J.
DO - 10.1080/07853890.2018.1427445
KW - adhesive agent
diamond
hydrogen peroxide
oxygen
placebo
ranitidine
resin
unclassified drug
adhesion
conference abstract
controlled study
dental procedure
drug therapy
human
in vitro study
machine
molar tooth
orthodontics
polymerization
post hoc analysis
rotation
tension
LA - English
PY - 2018
SN - 1365-2060
SP - S63-S64
ST - Effect of different gel bleaching agents on microtensile bond strength to
enamel
T2 - Ann. Med.
TI - Effect of different gel bleaching agents on microtensile bond strength to
enamel
VL - 50
ID - 13646
ER -
TY - JOUR
AB - INTRODUCTION: Therapeutic methods that inhibit microbial ingress into filled
root canals are desirable. This in vivo study assessed the inhibition of periapical
inflammation subsequent to coronal inoculation in canals medicated with 2%
chlorhexidine gel and filled with Resilon/Epiphany (Pentron Clinical Technologies,
Wallingford, CT). METHODS: Six Beagle dogs each had 10 two-rooted premolars
treated. In group 1 (n = 36 roots), 1 root/tooth had the canal conditioned with
Primer Epiphany, filled with Epiphany sealer and Resilon core in 1 session, and
coronally sealed with PhotacFil. In group 2 (n = 36 roots), the second root/tooth
had the canal medicated with 2% chlorhexidine gel for 1 week and then filled and
coronally sealed as in group 1. After 3 weeks, canals were exposed to the oral
environment for 7 days, inoculated with isologous plaque, and coronally sealed.
Negative controls treated as groups 1 and 2 remained sealed. Positive controls had
canals unfilled and exposed. Seven months after inoculation, dogs were euthanized;
jaw blocks processed for histologic examination; and periapical inflammation (PI)
recorded as none, mild, or severe. RESULTS: In groups 1 and 2, severe PI occurred
in 5 of 65 roots (8%) and mild PI in 18 of 65 roots (28%) with a significantly
higher (P = .031) PI incidence in group 2 than in group 1. Negative controls had
only mild PI in 9 of 29 roots (31%). Roots medicated with 2% chlorhexidine gel had
mild PI significantly more (P = .009) than roots filled in 1 session (more than 2-
fold). CONCLUSIONS: Intracanal medication with 2% chlorhexidine gel and root
filling with Resilon/Epiphany did not effectively inhibit apical periodontitis
subsequent to coronal inoculation.
AN - rayyan-563560424
AU - Santos, J. M.
AU - Palma, P. J.
AU - Ramos, J. C.
AU - Cabrita, A. S.
AU - Friedman, S.
DO - 10.1016/j.joen.2013.10.023
IS - 6
chlorhexidine
epiphany sealer
glass ionomer
Photac-Fil
resilon sealer
resin
animal
chemistry
classification
dental pulp cavity
dental surgery
devices
dog
drug effect
endodontics
female
microbiology
premolar tooth
procedures
tooth crown
tooth plaque
tooth radiography
tooth pulp disease
LA - English
PY - 2014
SN - 1878-3554
SP - 837-841
ST - Periapical inflammation subsequent to coronal inoculation of dog teeth root
filled with resilon/epiphany in 1 or 2 treatment sessions with chlorhexidine
medication
T2 - J Endod
TI - Periapical inflammation subsequent to coronal inoculation of dog teeth root
filled with resilon/epiphany in 1 or 2 treatment sessions with chlorhexidine
medication
VL - 40
ID - 13798
ER -
TY - JOUR
AB - Propolis has been shown to exibit in vitro antimicrobial activity against
periodontal pathogens. The aim of this study was to evaluate the efficacy of
Brazilian Green Propolis Mucoadherent Gel (BGPMG) for the treatment of patients
diagnosed with gingivitis and Chronic Periodontitis (CP). Six patients, 2 males
(36/42 years old) and 4 females (42, 46, 49,51 years old) with dental calculus,
gingivitis, oedema, bleeding, gingival recession, pocket depths, attachment loss,
suppuration, tooth mobility and alveolar bone loss were submitted at BGPG 10%
treatment. Dental archs were divided in the following quadrants. Superior Right
(SR) - BGPG irrigation; Superior Left (SL) - scraping/smoothing dental root (RAR)
and BGP irrigation inside the periodontal pocket; Inferior Right (IR) - RAR;
Inferior Left (IL)-control. Dental brushing with BGPG and washing mouth with
propolis solution daily was carried through during the treatment. BGPMG was applied
in each periodontal pocket once a week, during 4 weeks, having used barren
dismissable syringe. The results shown a regression of 95% gingivitis and
suppuration in all the teeth irrigated with BGPMG, as well as a pocket depths
reduction in all unsubmitted and submitted teeth previously to the RAR. It was not
observed alveolar bone reorganization. Increase of gingival contraction and dental
mobility reduction was noted. In this clinical study, the patient treated with the
BGPMG showed periodontitis/gingivitis regression. The results suggest that 10% BGPG
could be used as an adjuvant therapeutic method assigned for the treatment of CP.
Other studies need to be conducted with more significant number of patients in
order to stablish this treatment as an alternative approach for peridontal diseases
conditions.
AN - rayyan-563560675
AU - Santos, V. R.
AU - Gomes, R. T.
AU - Rocha, W. M. S.
AU - Polleto, L. T. A.
AU - Segura, M. E. C.
DO - 10.1055/s-0029-1235000
IS - 9
KW - propolis
natural product
adjuvant
periodontal pocket
medicinal plant
society
patient
gingivitis
periodontal disease
suppuration
tooth
male
female
tooth calculus
edema
bleeding
alveolar bone loss
tooth root
tooth brushing
syringe
alveolar bone
clinical study
in vitro study
pathogenesis
gingiva disease
LA - English
PY - 2009
SN - 0006-3223
ST - Periodontal pockets control with Brazilian green propolis mucoadherent gel
T2 - Planta Med.
TI - Periodontal pockets control with Brazilian green propolis mucoadherent gel
VL - 75
ID - 14049
ER -
TY - JOUR
AB - Aim The aim of this randomized controlled clinical trial was to evaluate the
clinical effects of chlorhexidine (CHX) application in a full-mouth disinfection
(FMD) protocol in poorly controlled type-2 diabetic subjects with generalized
chronic periodontitis. Material and Methods Thirty-eight subjects were randomly
assigned into FMD group (n=19): full-mouth scaling and root planing (FMSRP) within
24 h + local application of CHX gel + CHX rinses for 60 days or Control group (n =
19): FMSRP within 24 h + local application of placebo gel + placebo rinses for 60
days. Clinical parameters, glycated haemoglobin and fasting plasma glucose were
assessed at baseline, 3, 6 and 12 months post-therapies. Results All clinical
parameters improved significantly at 3, 6 and 12 months post-therapies for both
groups (p < 0.05). There were no significant differences between groups for any
clinical parameters, and glycemic condition at any time-point (p > 0.05).
Conclusions The treatments did not differ with respect to clinical parameters,
including the primary outcome variable (i.e. changes in clinical attachment level
in deep pockets), for up to 12 months post-treatments. © 2012 John Wiley & Sons
A/S.
AN - rayyan-563560496
AU - Santos, V. R.
AU - Lima, J. A.
AU - Miranda, T. S.
AU - Gonçalves, T. E. D.
AU - Faveri, M.
AU - Duarte, P. M.
DO - 10.1111/jcpe.12040
IS - 2
KW - chlorhexidine
glycated hemoglobin
adult
aged
article
blood
controlled study
female
gel
human
male
metabolism
middle aged
nonparametric test
pathology
periodontal disease
prospective study
treatment outcome
LA - English
PY - 2013
SN - ["0303-6979", "1600-051X"]
SP - 155-162
ST - Full-mouth disinfection as a therapeutic protocol for type-2 diabetic
subjects with chronic periodontitis: Twelve-month clinical outcomes. A randomized
TI - Full-mouth disinfection as a therapeutic protocol for type-2 diabetic
subjects with chronic periodontitis: Twelve-month clinical outcomes. A randomized
VL - 40
ID - 13870
ER -
TY - JOUR
AB - Periodontal disease is oral health problem which attacks 20-50% of the global
population. In Indonesia, 60% population suffers periodontal disease and become the
second most common disease in the oral cavity. Aggressive periodontitis (AP) is one
of periodontal disease, mainly attacks individual under 30 years-old, with rapid
alveolar bone destruction. Bone graft implantation surgery is the current treatment
for AP, but it is invasive and high risk infection. Nanohydroxyapatite-chitosan
(nHPA-CS) hydrogel injectable scaffold is non-invasive treatment that contains bone
mineral hydroxyapatite that derived from bovine bone and chitosan (CS) biopolymer
with low immunogenicity. Platelet-Rich-Fibrin (PRF) contains huge amount growth
factor which is biodegradable to human body. Buccal-Fat-Pad Stem-Cell (BFPSC) was
chosen because it is easy to harvest and able to differentiate into mesenchymal
lineage tissue. The aim of this narrative review is to describe the potential
combination of nanohydroxyapatite-chitosan hydrogel scaffold, platelet-rich-fibrin,
and buccal-fat-pad stem-cells for regenerating alveolar bone in aggressive-
periodontitis patients. Data was obtained by literature study scientific research
articles. In patients with AP, BFPSC can differentiate into osteoblast to improve
osteogenesis, nHPA-CS scaffold creates host like tissue microenvironment to
stimulate osteoinduction and osteoconduction activity of BFPSC, while PRF
stimulates osteogenic differentiation and proliferation of BFPSC with insulin
growth-factor, platelets derived growth-factor, transforming growth-factor,
fibroblast growth-factor, vascular endothelial growth-factor. this combination
increasing runt-related transcription-factor2, osterix, bone alkaline phosphatase,
and controls pro-inflammatory cytokines such as interleukin-1beta (IL-1b) and tumor
necrosis factor-alpha (TNF-a) so it can enhance bone regeneration and avoid bone
destruction. The combination of nHPA-CS, PRF, BFPSC has the potential for alveolar
bone regeneration in Aggressive-Periodontitis patients.
AN - rayyan-563559788
AU - Saputra, G.
AU - Nugraha, A. P.
AU - Budhy, T. I.
AU - Rosari, F. S.
AU - Lestari, N. A. I.
AU - Sari, A. A.
AU - Gheasani, A.
AU - Valensia, T.
AU - Ramadhani, N. F.
AU - Noor, T. N. E. B. T. A.
AU - Sosiawan, A.
DO - 10.52711/0974-360X.2022.00995
IS - 12
KW - alkaline phosphatase bone isoenzyme
CD146 antigen
chitosan derivative
collagen type 1
collagen type 2
collagenase 3
elastin
fibrin
growth factor
insulin
interleukin 1beta
interleukin 4
interleukin 6
nanohydroxyapatite
sialoprotein
transcription factor osterix
vasculotropin
von Willebrand factor
adult
alveolar bone
angiogenesis
biocompatibility
biodegradability
bone conduction
bone density
bone development
bone graft
bone mineral
bone regeneration
cell isolation
cell proliferation
clinical outcome
communicable disease
controlled study
cytokine release
fat pad
female
gene expression
human
male
ossification
osteoblast
osteoclast
osteoclastogenesis
osteocyte
osteolysis
review
signal transduction
thrombocyte
tissue engineering
tissue regeneration
LA - English
PY - 2022
SN - ["0974-360X", "0974-3618"]
SP - 5903-5908
ST - Nanohydroxyapatite-Chitosan Hydrogel Scaffold with Platelet Rich Fibrin and
Buccal Fat Pad derived Stem Cell for Aggressive Periodontitis Treatment: A
Narrative Review
TI - Nanohydroxyapatite-Chitosan Hydrogel Scaffold with Platelet Rich Fibrin and
Buccal Fat Pad derived Stem Cell for Aggressive Periodontitis Treatment: A
Narrative Review
VL - 15
ID - 13162
ER -
TY - JOUR
AB - Background: Robusta coffee beans contain very high chlorogenic acid. In the
last decade, chlorogenic acid was developed as an adjunct in stem cells to enhance
the anti-inflammatory and antioxidant properties of stem cells when used as a
therapeutic agent. Chlorogenic acid can increase proliferation and migration and
inhibit the production of pro-inflammatory cytokines in stem cells thereby
increasing the ability of stem cells to regenerate tissue. Purpose: To analyze the
levels of chlorogenic acid in robusta coffee bean extract which can be used as a
combination agent for Dental Pulp Stem Cells (DPSC) in periodontal tissue
engineering therapy. Materials and Methods: Robusta coffee bean extract was
obtained from the Coffee and Cocoa Research Center, Jember Regency which was
processed and processed using the fractionation method. This study used DPSC with
the extraction of premolar teeth of orthodontic patients. The toxicity test was
performed on the coffee extract 0.0625%; 0.125%; 0.25%; 0.5% to determine the
biocompatible concentration of DPSC. Results: The highest fractionation and
measurement of chlorogenic acid content obtained was 30.49%. Robusta coffee bean
extract with a chlorogenic acid content of 30.49% at concentrations of 0.125% and
0.0625% did not cause toxicity to DPSC. Conclusion: Chlorogenic acid in robusta
coffee bean extract concentrations of 0.125% and 0.0625% are relatively
biocompatible as a combination agent for DPSC in periodontal tissue engineering
therapy.
AN - rayyan-563559793
AU - Sari, D. S.
AU - Sakinah, N.
AU - Nuri
AU - Suswati, E.
AU - Widyowati, R.
AU - Maduratna, E.
DO - 10.52711/0974-360X.2022.00841
IS - 11
KW - antioxidant
CD34 antigen
chlorogenic acid
endoglin
Phaseolus vulgaris extract
receptor type tyrosine protein phosphatase C
silica gel
adult
article
bone remodeling
cementogenesis
coffee
controlled study
cytotoxicity
extraction
flow cytometry
fractionation
human
human cell
human tissue
MTT assay
orthodontics
osteoblast
periodontitis
periodontium
phytochemistry
solvent extraction
tissue engineering
toxicity testing
LA - English
PY - 2022
SN - ["0974-360X", "0974-3618"]
SP - 5005-5010
ST - Chlorogenic Acid Fractionation in Robusta Green Bean Extract as a Combination
Agent of Dental Pulp Stem Cells in Periodontal Tissue Engineering
TI - Chlorogenic Acid Fractionation in Robusta Green Bean Extract as a Combination
Agent of Dental Pulp Stem Cells in Periodontal Tissue Engineering
VL - 15
ID - 13167
ER -
TY - JOUR
AB - Fusobacterium nucleatum is a gram-negative and obligative anaerobic bacteria
species of fusobacteria phylum. This bacterium is invasive, proinflammatory and
related with bowel disease, periodontitis and pericarditis. It is also known that
F. nucleatum could be associated with colorectal cancer that is responsible for 610
000 deaths per year worldwide, according to the World Health Organisation.
Fusobacterium nucleatum metabolism needs to be further studied with the ultimate
aim of blocking bacterial infection. Lactate dehydrogenase enzyme (FnLDH) has a key
role in anaerobic glycolysis and producing intracellular biomolecules in the
bacterium. The gene encoding FnLDH has been successfully cloned into the pGEM-T
easy vector system in our previous study. Production of the active and soluble
protein following expression of the gene in an appropriate system is essential for
the structure based drug design studies. In this present study, FnLDH gene was
first cloned into expression vector pKK223-3 and protein was purified by affinity
chromatography. Thirty-four kDa protein was observed on SDS PAGE following the
protein purification. But satisfying production of FnLDH protein was not observed
by using this system. Therefore, FnLDH has been cloned into the pLATE 31 vector in
order to use advantages of aLICator LIC expression system. This study will be
providing further information to understand FnLDH metabolism beside optimization of
expression and purification of the enzyme.
AN - rayyan-563560480
AU - Sariyer, E.
AU - Erdemir, A.
AU - Milward, M. R.
AU - Cooper, P. R.
AU - Ozkan, E.
AU - Turgut-Balik, D.
DO - 10.1111/febs.12340
KW - lactate dehydrogenase
protein
oxidoreductase
enzyme
amoxicillin
gene
metabolism
anaerobic bacterium
intestine
phylum
colorectal cancer
periodontitis
Fusobacteria
health
anaerobic glycolysis
gene expression system
pericarditis
death
bacterial infection
species
drug design
expression vector
purification
LA - English
PY - 2013
SN - 1742-464X
SP - 617
ST - Expression of lactate dehydrogenase gene from Fusobacterium nucleatum
T2 - FEBS J.
TI - Expression of lactate dehydrogenase gene from Fusobacterium nucleatum
VL - 280
ID - 13854
ER -
TY - JOUR
AN - rayyan-563561666
AU - Chumakov, N. S.
AU - Drozdova, L. I.
AU - Yuffa, E. P.
DO - 10.46235/1028-7221-1010-CAO
IS - 2
PY - 2021
SP - 317-322
ST - COMPARATIVE ANALYSIS OF TREATMENT EFFICIENCY IN CHRONIC PERIODONTITIS USING
EXPERIMENTAL THERAPIES WITH PEPTIDE-CONTAINING PREPARATION AND POLYOXIDONIUM
T2 - Russian Journal of Immunology
TI - COMPARATIVE ANALYSIS OF TREATMENT EFFICIENCY IN CHRONIC PERIODONTITIS USING
EXPERIMENTAL THERAPIES WITH PEPTIDE-CONTAINING PREPARATION AND POLYOXIDONIUM
85165706520&doi=10.46235%2f1028-7221-1010-
CAO&partnerID=40&md5=fc210463fd5007a2423a0c49d9adad32
VL - 24
ID - 15040
ER -
TY - JOUR
AN - rayyan-563561662
AU - Drozdova, L. I.
AU - Umarova, D. S.
AU - Solovyova, D. A.
DO - 10.46235/1028-7221-010-AEO
IS - 1
PY - 2020
SP - 91-96
ST - ASSESSED EFFICACY OF POLYOXIDONIUM IN MEDICATED TREATMENT OF MODELLED CHRONIC
PERIODONTITIS (EXPERIMENTAL STUDY)
T2 - Russian Journal of Immunology
TI - ASSESSED EFFICACY OF POLYOXIDONIUM IN MEDICATED TREATMENT OF MODELLED CHRONIC
PERIODONTITIS (EXPERIMENTAL STUDY)
85165653586&doi=10.46235%2f1028-7221-010-
AEO&partnerID=40&md5=ba29d996805cdf0a2362f2dec97e92c2
VL - 23
ID - 15036
ER -
TY - JOUR
AB - Summary: Knowledge about security and the potential damage originated by the
gingival displacement techniques has not been described through randomised clinical
studies. This crossover, double-blind, randomised clinical trial evaluated clinical
and immunological factors related to conventional and cordless gingival
displacement (GD) techniques, and patients' perceptions in 12 subjects with the
employment of 2 GD techniques: conventional (gingival cord + 25% AlCl3 astringent
gel) and cordless (15% AlCl3 astringent-based paste). In each subject, two anterior
teeth were treated and a 10-day wash-out period separated the two treatments.
Periodontal indices were evaluated before (baseline) and 1 and 10 days after GD.
Interleukin 1β, interleukin 6 and tumour necrosis factor α concentrations in
gingival crevicular fluid were measured before and 1 day after GD. Subjective
parameters (pain, unpleasant taste and stress) were also evaluated. Data were
analysed by one-way repeated-measures analysis of variance and Tukey's test
(immunological factors), the Friedman test (periodontal parameters) and Fisher's
exact or chi-squared test (subjective parameters), with a significance level of
95%. Gingival bleeding index, probing depth and plaque index values did not differ
significantly between groups at any timepoint. Neither technique resulted in worse
periodontal indices. Both techniques yielded similar results for pain and
unpleasant taste, but conventional GD was significantly more stressful than
cordless GD for volunteers. Both treatments significantly increased mean
concentrations of the three cytokines, with the conventional technique producing
the highest cytokine levels. Cordless GD is less stressful for patients and results
in lower post-treatment levels of inflammatory cytokines compared with conventional
GD. © 2014 John Wiley & Sons Ltd.
AN - rayyan-563560432
AU - Sarmento, H. R.
AU - Leite, F. R. M.
AU - Dantas, R. V. F.
AU - Ogliari, F. A.
AU - Demarco, F. F.
AU - Faot, F.
DO - 10.1111/joor.12142
IS - 4
KW - astringent agent
cytokine
interleukin 1beta
interleukin 6
adult
article
chemistry
controlled study
dental impression
female
gingiva
gingival retraction technique
gingivitis
human
immunology
male
middle aged
periodontics
tooth prosthesis
treatment outcome
LA - English
PY - 2014
SN - ["1365-2842", "0305-182X"]
SP - 306-313
ST - A double-blind randomised clinical trial of two techniques for gingival
displacement
T2 - J. Oral Rehabil.
TI - A double-blind randomised clinical trial of two techniques for gingival
displacement
VL - 41
ID - 13806
ER -
TY - JOUR
AB - Background: Porphyromonas gingivalis is a major pathogen and has a high
detection rate in periodontal disease. Fimbriae and hemagglutinin are expressed by
P. gingivalis, and these play an important role in the adherence of the bacteria to
periodontal tissue and biofilm formation. The aim of this study was to investigate
the effects of sub-minimal inhibitory concentrations (sub-MICs) of azithromycin on
the adherence of P. gingivalis, focusing on the inhibition of fimbriae expression
and hemagglutinin activity. Methods: P. gingivalis ATCC 33277 were incubated
anaerobically with sub-MICs of azithromycin at 37◦ C by gentle shaking for 18
hours. The bacterial cells were harvested, washed twice with phosphate-buffered
saline (PBS), and the proteins analyzed by 12% sodium dodecyl sulfate-
polyacrylamide gel electrophoresis (SDS-PAGE) and western blotting. Adherence assay
and hemagglutinin activity tests were done with the same culture. Results: The
results of SDS-PAGE indicated that the sub-MICs of azithromycin inhibited 41-kDa
fimbrial protein expression and hemagglutinin activities. The disappearance of 41-
kDa fimbrial protein expression and long fimbriae in 0.4 μg/mL, 0.2 μg/mL, and 0.1
μg/mL of azithromycin was confirmed by western blotting and transmission electron
microscopy. The adherence of P. gingivalis to human gingival epithelial cells was
reduced by sub-MICs of azithromycin compared with the adherence levels without
antibiotic. Conclusions: These results suggest that sub-MICs of azithromycin may
reduce the adherence of P. gingivalis to host cells, by inhibiting production of
fimbriae and hemagglutinin activities. Therefore, azithromycin can be used as a
biofilm treatment of periodontal disease caused by P. gingivalis.
AN - rayyan-563560218
AU - Sasaki, H.
AU - Inaba, K.
AU - Watanabe, K.
AU - Hamada, N.
AU - Kan, P.
AU - Minabe, M.
DO - 10.1002/JPER.18-0559
IS - 8
KW - article
bacterial cell
bacterium culture
biofilm
controlled study
epithelium cell
fimbria
gingivitis
host cell
human
microbiology
nonhuman
periodontal disease
periodontitis
protein expression
protein function
stomatology
Western blotting
antibiotic agent
antiinfective agent
azithromycin
hemagglutinin
LA - English
PY - 2019
SN - 0022-3492
SP - 903-910
ST - Inhibitory effects of azithromycin on the adherence ability of Porphyromonas
gingivalis
TI - Inhibitory effects of azithromycin on the adherence ability of Porphyromonas
gingivalis
VL - 90
ID - 13592
ER -
TY - JOUR
AB - Porphyromonas gingivalis is the most common microorganism associated with
adult periodontal disease, causing inflammation around the subgingival lesion. In
this study, we investigated tryptophanyl tRNA synthase (WRS) production by THP-1
cells infected with P. gingivalis. Cytokine production, leukocyte adhesion
molecules, and low-density lipoprotein receptor (LDLR) expressions in cultured
cells were examined. WRS was detected in THP-1 cell culture supernatants stimulated
with P. gingivalis from 1 to 24 h, and apparent production was observed after 4 h.
No change in WRS mRNA expression was observed from 1 to 6 h in THP-1 cells, whereas
its expression was significantly increased 12 h after stimulation with P.
gingivalis. Lactate dehydrogenase (LDH) activity was observed from 4 to 24 h. The
TNF-α, IL-6, IL-8, and CXCL2 levels of THP-1 cells were upregulated after treatment
with recombinant WRS (rWRS) and were significantly reduced when THP-1 cells were
treated with C29. The MCP-1, ICAM-1, and VCAM-1 levels in human umbilical vein
endothelial cells were upregulated following treatment with rWRS, and TAK242
suppressed these effects. Additionally, unmodified LDLR, macrophage scavenger
receptor A, and lectin-like oxidized LDLRs were upregulated in THP-1 cells treated
with rWRS. These results suggest that WRS from macrophages infected with P.
gingivalis is associated with atherosclerosis.
AN - rayyan-563559938
AU - Sasaki, M.
AU - Shimoyama, Y.
AU - Kodama, Y.
AU - Ishikawa, T.
DO - 10.3390/pathogens10121648
IS - 12
KW - cDNA microarray kit
ELISA kit
imaging software
lactate dehydrogenase test kit
MyBioSource
amino acid transfer RNA ligase
beta actin
CD36 antigen
chemokine
complementary DNA
CXCL2 chemokine
interleukin 6
interleukin 8
lectin
low density lipoprotein receptor
oxidized low density lipoprotein receptor 1
polymyxin derivative
resatorvid
scavenger receptor A
tryptophan transfer RNA ligase
article
atherosclerosis
cell component
cell lysate
cytokine production
DNA sequencing
fetal bovine serum
gene expression
human
human cell
HUVEC cell line
immunofluorescence
inflammation
macrophage
multiplicity of infection
periodontal disease
protein expression
THP-1 cell line
TLR signaling
upregulation
Western blotting
RNeasy
LA - English
PY - 2021
SN - 2076-0817
ST - Tryptophanyl tRNA Synthetase from Human Macrophages Infected by Porphyromonas
gingivalis Induces a Proinflammatory Response Associated with Atherosclerosis
T2 - Pathogens
TI - Tryptophanyl tRNA Synthetase from Human Macrophages Infected by Porphyromonas
gingivalis Induces a Proinflammatory Response Associated with Atherosclerosis
VL - 10
ID - 13312
ER -
TY - JOUR
AB - The aim of this investigation was to monitor metronidazole concentrations in
the gingival crevicular fluid (GCF) collected from periodontal pockets of dogs
after treatment with an experimental 15% metronidazole gel. Five dogs had
periodontitis induced by cotton ligatures placed subgingivally and maintained for a
30-day period. After the induction period, only pockets with 4 mm or deeper
received the gel. Each pocket was filled up to the gingival margin by means of a
syringe with a blunt-end needle. GCF was collected in paper strips and quantified
in an electronic device before and after 15 minutes, 1 h, 6 h, 24 h and 48 h of gel
administration. The GCF samples were assayed for metronidazole content by means of
a high performance liquid chromatography method. Concentrations of metronidazole in
the GCF of the 5 dogs (mean ± SD, in μg/mL) were 0 ± 0 before gel application and
47,185.75 ± 24,874.35 after 15 minutes, 26,457.34 ± 25,516.91 after 1 h, 24.18 ±
23.11 after 6 h, 3.78 ± 3.45 after 24 h and 3.34 ± 5.54 after 48 h. A single
administration of the 15% metronidazole gel released the drug in the GCF of dogs in
levels several-fold higher than the minimum inhibitory concentration for some
periodontopathogens grown in subgingival biofilms for up to one hour, but
metronidazole could be detected in the GCF at least 48 hours after the get
application.
AN - rayyan-563560689
AU - Sato, S.
AU - Fonseca, M. J. V.
AU - Del Ciampo, J. O.
AU - Jabor, J. R.
AU - Pedrazzi, V.
DO - 10.1590/S1806-83242008000200009
IS - 2
metronidazole
animal
article
chemistry
dog
drug screening
female
gel
gingivitis
male
periodontitis
LA - English
PY - 2008
SN - ["1806-8324", "1807-3107"]
SP - 145-150
ST - Metronidazole-containing gel for the treatment of periodontitis: An in vivo
evalution
T2 - Braz. Oral Res.
TI - Metronidazole-containing gel for the treatment of periodontitis: An in vivo
evalution
VL - 22
ID - 14063
ER -
TY - JOUR
AB - The aim of this investigation was to monitor metronidazole concentrations in
the gingival crevicular fluid (GCF) collected from periodontal pockets of dogs
after treatment with an experimental 15 percent metronidazole gel. Five dogs had
periodontitis induced by cotton ligatures placed subgingivally and maintained for a
30-day period. After the induction period, only pockets with 4 mm or deeper
received the gel. Each pocket was filled up to the gingival margin by means of a
syringe with a blunt-end needle. GCF was collected in paper strips and quantified
in an electronic device before and after 15 minutes, 1 h, 6 h, 24 h and 48 h of gel
administration. The GCF samples were assayed for metronidazole content by means of
a high performance liquid chromatography method. Concentrations of metronidazole in
the GCF of the 5 dogs (mean ± SD, in µg/mL) were 0 ± 0 before gel application and
47,185.75 ± 24,874.35 after 15 minutes, 26,457.34 ± 25,516.91 after 1 h, 24.18 ±
23.11 after 6 h, 3.78 ± 3.45 after 24 h and 3.34 ± 5.54 after 48 h. A single
administration of the 15 percent metronidazole gel released the drug in the GCF of
dogs in levels several-fold higher than the minimum inhibitory concentration for
some periodontopathogens grown in subgingival biofilms for up to one hour, but
metronidazole could be detected in the GCF at least 48 hours after the gel
application.
AN - rayyan-563559884
AU - Sato, Sandra
AU - Fonseca, Maria José Vieira
AU - Ciampo, José Orestes Del
AU - Jabor, José Roberto
AU - Pedrazzi, Vinícius
IS - 2
KW - Drug delivery systems
Metronidazole
Periodontitis
LA - en
PY - 2008
SN - 1806-8324
SP - 145-150
ST - Metronidazole-containing gel for the treatment of periodontitis: an in vivo
evaluation
T2 - Braz. oral res
TI - Metronidazole-containing gel for the treatment of periodontitis: an in vivo
evaluation
83242008000200009
VL - 22
ID - 13258
ER -
TY - JOUR
AB - OBJECTIVE: The purpose of this study was to isolate the active antibacterial
compounds from Bilberry (Vaccinium myrtillus L.) against periodontopathic bacteria.
METHODS: The acetone soluble fraction of Bilberry was extracted from the oil layer
by oil/water separation. The extract was then purified by a silica gel open column
chromatography. The minimum inhibitory concentration (MIC) of the total extract or
purified fractions against bacteria was measured at each step. RESULTS: The MIC of
the total extract against Porphyromonas gingivalis was 500 μg/mL. The fraction
exhibiting antibacterial activity against P. gingivalis was called NU4-TDC, and its
MICs against P. gingivalis, Fusobacterium nucleatum, and Prevotella intermedia were
26.0 ± 7.8 μg/mL, 59.0 ± 10.4 μg/mL, and 45.1 ± 16.5 μg/mL, respectively. The MIC
against Streptococcus mutans was >62.5 μg/mL. CONCLUSION: Bilberry contains
antibacterial components against periodontopathic bacteria, such as P. gingivalis,
F. nucleatum, and P. intermedia.
AN - rayyan-563560121
AU - Satoh, Y.
AU - Ishihara, K.
DO - 10.1016/j.job.2020.01.009
IS - 2
KW - plant extract
bilberry
LA - English
PY - 2020
SN - 1880-3865
SP - 169-174
ST - Investigation of the antimicrobial activity of Bilberry (Vaccinium myrtillus
L.) extract against periodontopathic bacteria
T2 - J Oral Biosci
TI - Investigation of the antimicrobial activity of Bilberry (Vaccinium myrtillus
L.) extract against periodontopathic bacteria
VL - 62
ID - 13495
ER -
TY - JOUR
AB - Dental caries is one of the most significant health problems facing older
adults. More than half of the elderly who are dentate are affected with either
coronal or root caries, and caries is the primary cause of tooth loss in this
population. New materials and techniques are emerging to help with geriatric
preventive and restorative. needs, but ongoing vigilance for caries will be
required in this population, which is experiencing increased longevity and tooth
retention.
AN - rayyan-563560846
AU - Saunders Jr, R. H.
AU - Meyerowitz, C.
DO - 10.1016/j.cden.2004.10.004
IS - 2
KW - antiasthmatic agent
beta adrenergic receptor blocking agent
chlorhexidine
fluoride
sodium fluoride
toothpaste
xylitol
age distribution
aging
clinical trial
dental procedure
dental caries
disease association
drug efficacy
drug formulation
endodontics
epidemiological data
ethnic difference
gel
geographic distribution
health care cost
health survey
human
incidence
medical fee
nursing home
pathogenesis
patient education
periodontal disease
prevalence
prophylaxis
quality of life
review
risk assessment
risk factor
tooth crown
tooth extraction
tooth root
treatment planning
varnish
LA - English
PY - 2005
SN - 0011-8532
SP - 293-308
ST - Dental caries in older adults
TI - Dental caries in older adults
VL - 49
ID - 14220
ER -
TY - JOUR
AB - This study is aimed at the evaluation of a 1% clindamycin hydrochloride
containing gel on the microbial flora of periodontal pockets deeper than 5 mm. In
order to achieve that purpose. 20 patients with pocketing in the premolar-molar
regions were selected. Active and placebo gel were inserted once during the first 2
weeks of this experimental study. Microbial samplings were performed 1, 2, 4 and 12
weeks after the experiment started. The samples were submitted to microscopic
examination and also to culture. Changes in the microbial content of the
periodontal pockets treated by subgingival scaling and clindamycin 1% gel were
significant, compared with those obtained with subgingival scaling and placebo gel,
particularly with respect to anaerobic black-pigmented bacteria and the motile
gram-negative flora. However, after 3 months, most of the treated cases were
recolonized by the same initial species, though never at pre-clindamycin levels. In
the light of this study, it will be concluded that the use of a small amount of
clindamycin hydrochlolide inserted into a periodontal pocket, once a week for 2
weeks as a complement to periodontal subgingival scaling, is beneficial in the
treatment of adult periodontitis, by eliminating more effectively the microbial
pocket colonization.
AN - rayyan-563561087
AU - Sauvetre, E.
AU - Glupczynsky, Y.
AU - Labbe, M.
AU - Yourassowsky, E.
AU - Pourtois, M.
IS - 4
KW - aminoglycoside antibiotic agent
clindamycin
adult
article
bacterium culture
clinical article
clinical trial
controlled study
female
human
male
microscopy
molar tooth
mouth flora
periodontitis
premolar tooth
priority journal
LA - English
PY - 1993
SN - 0300-8126
SP - 245-247
ST - The effect of clindamycin gel insert in periodontal pockets, as observed on
smears and cultures
T2 - INFECTION
TI - The effect of clindamycin gel insert in periodontal pockets, as observed on
smears and cultures
VL - 21
ID - 14461
ER -
TY - JOUR
AB - Oral spirochetes have been shown to be associated with periodontal diseases
and are present in increased numbers in lesions of greater severity. In this study,
the interaction of Treponema denticola with human complement, a major antibacterial
defense system, was examined. For each of two strains of T. denticola, it was found
that both the classical and alternative pathways of human complement were activated
in human serum upon incubation at 37 degrees C. C3 fragments were deposited on the
surface of this organism following complement activation; the fragments bound
included both of the major C3-derived opsonic fragments C3b and iC3b. Under
incubation conditions identical to those carried out for complement activation in
serum, T. denticola failed to degrade purified, hemolytically-active C3, although
it readily degraded inactivated C3. Thus, despite the documented proteolytic
activity of this organism, complement activation and deposition of complement-
derived opsonins may be important defense mechanisms in the control of infections
with T. denticola.
AN - rayyan-563561165
AU - Schenkein, H. A.
AU - Berry, C. R.
IS - 2
KW - complement component C3
complement component C3b
complement component C4
opsonin
article
complement alternative pathway
complement classical pathway
complement hemolysis test
human
immunology
microbiology
pathogenicity
tooth plaque
Treponema
LA - English
PY - 1991
SN - 0022-0345
SP - 107-110
ST - Activation of complement by Treponema denticola
T2 - J. Dent. Res.
TI - Activation of complement by Treponema denticola
VL - 70
ID - 14539
ER -
TY - JOUR
AB - This study evaluated the effects of an at-home vital bleaching system on
gingival responses over a 6-week period. Objective measures were utilized to
measure and monitor gingival inflammation over this period of time. Vital bleaching
was performed as follows: (1) bleaching gel in a prefabricated mouthguard and (2)
an ad-mix technique--bleaching gel and toothpaste in a 1:1 ratio. In addition a
control group used a placebo in a prefabricated mouthguard. The at-home vital
bleaching system produced no adverse gingival tissue responses. Furthermore, the
at-home vital bleaching system helped produce a therapeutic effect on inflamed
gingival tissues over the course of the study.
AN - rayyan-563561155
AU - Scherer, W.
AU - Palat, M.
AU - Hittelman, E.
AU - Putter, H.
AU - Cooper, H.
IS - 3
peroxide
toothpaste
urea
carbamide peroxide
adult
article
dental procedure
dental device
drug combination
drug effect
female
gel
gingiva
gingivitis
human
male
middle aged
periodontics
LA - English
PY - 1992
SN - 1040-1466
SP - 86-89
ST - At-home bleaching system: effect on gingival tissue
T2 - J Esthet Dent
TI - At-home bleaching system: effect on gingival tissue
VL - 4
ID - 14529
ER -
TY - JOUR
AB - PURPOSE: To determine whether mechanical cleaning with interdental brushes
combined with the use of cetylpyridinium chloride (0.3% CPC) gel was more effective
at plaque control than mechanical cleaning with interdental brushes alone.
MATERIALS AND METHODS: Forty individuals (30-70 years old) with at least 20 teeth
and moderate chronic periodontitis who had no experience with interdental cleaning
aids were randomly assigned to a treatment group (brush + gel, n = 20) or a control
group (brush, n = 20). Both groups were examined by a dentist at baseline and at 3
and 6 months for changes in interdental plaque (interproximal plaque index [API])
levels, gingival inflammation (sulcus bleeding index [SBI]), probing depth (PD) and
bleeding on probing (BOP). RESULTS: No baseline differences in age, gender or
number of teeth were observed between the two groups. During the study period,
improvements in API and BOP were comparable between groups. However, improvements
in SBI and PD were significantly greater in the test group than in the control
group (p = 0.046 and p = 0.029, respectively). CONCLUSION: Mechanical interdental
plaque control using interdental brushes combined with the use of CPC gel
significantly improved 6-month gingival and periodontal outcomes (SBI and PD)
compared with mechanical cleaning with interdental brushes alone.
AN - rayyan-563560401
AU - Schmidt, B.
AU - Jentsch, H.
DO - 10.3290/j.ohpd.a32680
IS - 3
adult
aged
comparative study
controlled study
dental device
tooth plaque
devices
female
follow up
gingivitis
human
male
middle aged
mouth hygiene
periodontics
prospective study
treatment outcome
LA - English
PY - 2015
SN - 1602-1622
SP - 205-211
ST - Comparison Between Two Interproximal Cleaning Procedures in Periodontitis
Patients: A Six-month, Single-blind, Randomised Controlled Clinical Trial
TI - Comparison Between Two Interproximal Cleaning Procedures in Periodontitis
Patients: A Six-month, Single-blind, Randomised Controlled Clinical Trial
VL - 13
ID - 13775
ER -
TY - JOUR
AB - The effects of compressive strain during orthodontic treatment on gene
expression profiles of periodontal ligament fibroblasts (PDLFs) have mostly been
studied in 2D cell culture. However, cells behave differently in many aspects in 3D
culture. Therefore, the effect of pressure application on PDLFs in different 3D
structures was investigated. PDLFs were either conventionally seeded or embedded
into different 3D structures (spheroids, Mebiol® gel, 3D scaffolds) and exposed to
compressive force or incubated without pressure. For one 3D scaffold (POR), we also
tested the effect of different compressive forces and application times. Expression
of an angiogenic gene (VEGF), a gene involved in extracellular matrix synthesis
(COL1A2), inflammatory genes (IL6, PTGS2), and genes involved in bone remodelling
(OPG, RANKL) were investigated by RT–qPCR. Depending on the used 3D cell culture
model, we detected different effects of compressive strain on expression profiles
of PDLFs. COL1A2 was downregulated in all investigated 3D culture models.
Angiogenetic and proinflammatory genes were regulated differentially between
models. In 3D scaffolds, regulation of bone-remodelling genes upon compressive
force was contrary to that observed in 3D gels. 3D cell culture models provide
better approximations to in vivo physiology, compared with conventional 2D models.
However, it is crucial which 3D structures are used, as these showed diverse
effects on the expression profiles of PDLFs during mechanical strain.
AN - rayyan-563559902
AU - Schröder, A.
AU - Schöniger, R.
AU - Oeldemann, J.
AU - Spanier, G.
AU - Proff, P.
AU - Jantsch, J.
AU - Kirschneck, C.
AU - Ullrich, N.
DO - 10.3390/ijms23042029
IS - 4
KW - 96G-Biometra
cell culture plate
agarose
antibiotic agent
antifungal agent
ascorbic acid
collagen binding protein
Collagen Type I Alpha 2 Chain
complementary DNA
cyclooxygenase 2
cyclophilin A
glutamine
hydrogel
interleukin 6
mebiol
nanofiber
osteoprotegerin
polycaprolactone
Prostaglandin endoperoxide synthase 2
Receptor activator of NFk-B ligand
Ribosomal protein L22
ribosome protein
unclassified drug
vasculotropin
zirconium oxide
article
Compressive Strain
DNA synthesis
enzyme assay
fibroblast
human cell
normal human
RNA isolation
three dimensional cell culture
tumor spheroid
two dimensional cell culture
LA - English
PY - 2022
SN - ["1422-0067", "1661-6596"]
ST - An Evaluation of Different 3D Cultivation Models on Expression Profiles of
Human Periodontal Ligament Fibroblasts with Compressive Strain
TI - An Evaluation of Different 3D Cultivation Models on Expression Profiles of
Human Periodontal Ligament Fibroblasts with Compressive Strain
VL - 23
ID - 13276
ER -
TY - JOUR
AB - Culture supernatants from Treponema maltophilum associated with periodontitis
in humans and Treponema brennaborense found in a bovine cattle disease accompanied
with cachexia caused a dose-dependent TNF-alpha synthesis in human monocytes
increasing with culture time. This activity could be reduced significantly by
blocking the CD14-part of the LPS receptor using the My 4 mAb and by polymyxin B.
In the murine macrophage cell line RAW 264.7, Treponema culture supernatants
induced TNF-alpha secretion in a LPS binding protein (LBP)-dependent fashion. To
enrich for active compounds, supernatants were extracted with butanol, while whole
cells were extracted using a phenol/water method resulting in recovery of material
exhibiting a similar activity profile. An LPS-LBP binding competition assay
revealed an interaction of the treponeme phenol/water extracts with LBP, while
precipitation studies implied an affinity to polymyxin B and endotoxin neutralizing
protein. Macrophages obtained from C3H/HeJ mice carrying a Toll-like receptor
(TLR)-4 mutation were stimulated with treponeme extracts for NO release to assess
the role of TLRs in cell activation. Furthermore, NF-kappaB translocation in TLR-2-
negative Chinese hamster ovary (CHO) cells was studied. We found that phenol/water-
extracts of the two strains use TLRs differently with T. brennaborense-stimulating
cells in a TLR-4-dependent fashion, while T. maltophilum-mediated activation
apparently involved TLR-2. These results indicate the presence of a novel class of
glycolipids in Treponema initiating inflammatory responses involving LBP, CD14, and
TLRs.
AN - rayyan-563561454
AU - Schröder, N. W.
AU - Opitz, B.
AU - Lamping, N.
AU - Michelsen, K. S.
AU - Zähringer, U.
AU - Göbel, U. B.
AU - Schumann, R. R.
DO - 10.4049/jimmunol.165.5.2683
IS - 5
J2 - J Immunol
KW - *Acute-Phase Proteins
Animals
Antibodies, Monoclonal/pharmacology
Antimicrobial Cationic Peptides
Arthropod Proteins
Binding Sites/immunology
Biological Transport/genetics
Blood/microbiology
Butanols
CHO Cells
Carrier Proteins/genetics/metabolism/*physiology
Cell Line
Cell Wall/chemistry
Cells, Cultured
Cricetinae
Cytokines/biosynthesis
*Drosophila Proteins
Female
Glycolipids/*immunology
Humans
Immunity, Innate
Invertebrate Hormones/metabolism
Lipopolysaccharide Receptors/*physiology
Lipopolysaccharides/*metabolism
Macrophages, Peritoneal/immunology/metabolism/microbiology
Membrane Glycoproteins/*physiology
Mice
Mice, Inbred C3H
Monocytes/immunology/metabolism
NF-kappa B/metabolism
Nitric Oxide/biosynthesis
Phenol
Polymyxin B/metabolism/pharmacology
Receptors, Cell Surface/*physiology
Recombinant Proteins/pharmacology
Silver
Staining and Labeling
Toll-Like Receptor 2
Toll-Like Receptor 4
Toll-Like Receptors
Treponema/chemistry/growth & development/*immunology
Tumor Necrosis Factor-alpha/biosynthesis
Water
LA - eng
N1 - Institut für Mikrobiologie und Hygiene, Universitätsklinikum Charité
Medizinische Fakultät der Humboldt-Universität zu Berlin, Berlin, Germany.
PY - 2000
SN - 0022-1767 (Print)
SP - 2683-93
ST - Involvement of lipopolysaccharide binding protein, CD14, and Toll-like
receptors in the initiation of innate immune responses by Treponema glycolipids
T2 - Journal of immunology (Baltimore, Md. : 1950)
TI - Involvement of lipopolysaccharide binding protein, CD14, and Toll-like
receptors in the initiation of innate immune responses by Treponema glycolipids
VL - 165
Y2 - 9 y3 - 1
ID - 14828
ER -
TY - JOUR
AB - An investigative study was performed to evaluate changes in gingival health
with the application of a 10% carbamide peroxide bleaching gel using exposure times
of 2 and 7 hours (overnight). The presence or absence of gingival inflammation was
recorded using the Loe and Silness Gingival Index at intervals over a 28-day
period. The results showed no statistical significance between the preoperative
gingival index scores and those recorded at any point during the study, regardless
of exposure time.
AN - rayyan-563561086
AU - Schulte, J. R.
AU - Morrissette, D. B.
AU - Gasior, E. J.
AU - Czajewski, M. V.
IS - 11
peroxide
urea
carbamide peroxide
adult
article
clinical trial
controlled study
dental procedure
dental device
drug combination
female
gel
gingivitis
human
devices
male
methodology
periodontics
self care
time
LA - English
PY - 1993
SN - 0894-1009
SP - 1362, 1364-1366, passim; quiz 1372
ST - Clinical changes in the gingiva as a result of at-home bleaching
T2 - Compendium
TI - Clinical changes in the gingiva as a result of at-home bleaching
VL - 14
ID - 14460
ER -
TY - JOUR
AN - rayyan-563560997
AU - Schwach-Abdellaoui, K.
AU - Heller, J.
AU - Gurny, R.
IS - 26
KW - poly(ortho ester)
tetracycline
biodegradation
conference paper
drug synthesis
gamma irradiation
hydrophobicity
molecular weight
periodontitis
LA - English
PY - 1999
SN - 1022-0178
SP - 697-698
ST - Bioerodible devices based on poly(ortho esters) for controlled delivery of
tetracycline to periodontal pocket
T2 - Proc. Control. Release Soc.
TI - Bioerodible devices based on poly(ortho esters) for controlled delivery of
tetracycline to periodontal pocket
ID - 14371
ER -
TY - JOUR
AB - Periodontitis is an inflammatory disease of the supporting tissues of the
teeth caused by groups of specific microorganisms. Aggressive forms of
periodontitis can be localized or generalized. The concept that localized problem
sites may be treated by local drug delivery appears attractive as the antimicrobial
agent is delivered within periodontal pockets and the therapy is targeted on
specific pathogenic microorganisms. Local delivery of antimicrobial agents using
controlled release systems should be considered as adjunctive to mechanical
debridement for the treatment of localized forms of periodontal destruction. This
article reviews various types of delivery systems evaluated in practical
periodontal therapy. Despite the large number of studies showing an enhanced
effectiveness of local antibiotherapy, there are insufficient comparative data to
support any of the local delivery system. (C) 2000 Elsevier Science B.V. All rights
reserved.
AN - rayyan-563562055
AU - Schwach-Abdellaoui, K.
AU - Vivien-Castioni, N.
AU - Gurny, R.
DO - 10.1016/S0939-6411(00)00086-2
IS - 1
PY - 2000
SN - ["0939-6411", "1873-3441"]
SP - 83-99
ST - Local delivery of antimicrobial agents for the treatment of periodontal
diseases
T2 - EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
TI - Local delivery of antimicrobial agents for the treatment of periodontal
diseases
VL - 50
Y2 - 7
ID - 15429
ER -
TY - JOUR
AB - Objective: The aim of the present study was to evaluate non-submerged and
submerged healing of ligature induced peri-implantitis in dogs. Material and
Methods: Peri-implantitis was induced by ligature placement in five beagle dogs (n
= 30 implants). The defects were randomly and equally allocated in a split-mouth
design to either closed treatment+non-submerged healing (CNS), or open
treatment+submerged healing (OS) using an Er:YAG laser (ERL), an ultrasonic device
(VUS), or plastic curettes+local application of metronidazole gel (PCM),
respectively. The animals were sacrificed after 3 months. Clinical, radiological
and histological (e.g. new bone-to-implant contact (BIC)) parameters were assessed.
Results: All treatment procedures resulted in statistically significant
improvements of all clinical parameters at both CNS and OS implants. Radiological
improvements were merely observed at OS implants. Histomorphometrical analysis
revealed that all CNS implants exhibited comparable low amounts of new BIC (1.0-
1.2%), while mean BIC was statistically significant higher in the respective OS
groups [ERL (44.8%), PCM (14.8%), VUS (8.7%)]. Conclusion: Within the limits of the
present study, it was concluded that (i) OS improved the outcome of treatment in
comparison with CNS and (ii) ERL seemed to be more suitable to promote re-
osseointegration than PCM and VUS. © 2006 The Authors.
AN - rayyan-563560764
AU - Schwarz, F.
AU - Jepsen, S.
AU - Herten, M.
AU - Sager, M.
AU - Rothamel, D.
AU - Becker, J.
DO - 10.1111/j.1600-051X.2006.00956.x
IS - 8
KW - aluminum silicate
antiinfective agent
erbium
metronidazole
plastic
yttrium
animal
article
bone regeneration
disease model
dog
female
devices
laser surgery
ligation
methodology
pathology
periodontics
periodontitis
physiology
radiography
randomization
tooth implantation
treatment outcome
ultrasound therapy
wound healing
LA - English
PY - 2006
SN - ["0303-6979", "1600-051X"]
SP - 584-595
ST - Influence of different treatment approaches on non-submerged and submerged
healing of ligature induced peri-implantitis lesions: An experimental study in dogs
TI - Influence of different treatment approaches on non-submerged and submerged
healing of ligature induced peri-implantitis lesions: An experimental study in dogs
VL - 33
ID - 14138
ER -
TY - JOUR
AB - Aim: The aim of the present experiment was to study the effect of different
chlorhexidine regimens on the number of bacteria in saliva, and on de novo plaque
formation. Material and Methods: Ten subjects with gingivitis, but no signs of
destructive periodontitis, were recruited. Following a screening examination, the
volunteers were given oral hygiene instruction, meticulous scaling and professional
mechanical tooth cleaning (PTC). The PTC was repeated once every 3 days during a 2-
week period to establish healthy gingival conditions. The study was designed as a
double-blind crossover clinical trial including three phases. Each experimental
phase comprised one preparatory period of 7 days and one plaque accumulation period
(no oral hygiene measures) of 4 days. During all preparatory periods, the
volunteers (i) performed mechanical tooth cleaning using a toothbrush and
dentifrice and (ii) were, in addition, given two sessions of PTC. The final PTC was
delivered after bacterial sampling had been made on Day 0. Preparatory period A:
the participants continued the self-performed plaque control regimen that employed
only mechanical means. Preparatory period B: the participants were in addition
instructed to rinse and gargle, twice daily, with a 0.2% chlorhexidine mouthrinse.
Preparatory period C: in addition to the above, the participants were instructed to
brush the dorsum of the tongue for 60 s, twice daily, with a 1.0% chlorhexidine
gel. Following each plaque accumulation period, there was a 10-day washout
interval. The presence and amount of dental plaque (QHI) was scored after 1, 2 and
4 days of no oral hygiene. Samples of saliva were obtained on Day 0 and after 1 and
2 days. The samples were placed on Brucella agar plates and incubated
(anaerobically) for 5 days. The total number of colony-forming units was determined
and used to estimate the density of bacteria in saliva. Results: In period A, the
mean QHI increased from 1.0 (Day 1) to 1.4 (Day 2) and 2.1 (Day 4). The
corresponding scores for periods B and C were 0.5, 0.8, 1.6 and 0.3, 0.8, 1.2,
respectively. At all re-examination intervals more plaque formed during period A
than during periods B and C. Further, during period C, less plaque formed than that
during period B. Saliva samples from Day 0 in period A contained a larger number of
TVC than the baseline samples in periods B and C. There was no significant
difference in TVC among the groups on Day 2. Conclusion: The daily use of
chlorhexidine as an adjunct to mechanical tooth cleaning markedly reduced the
number of microorganisms that could be detected in saliva. The number of salivary
bacteria may have influenced the amount of plaque that formed during an early phase
of no oral hygiene.
AN - rayyan-563560877
AU - Sekino, S.
AU - Ramberg, P.
AU - Uzel, N. G.
AU - Socransky, S.
AU - Lindhe, J.
DO - 10.1034/j.1600-051X.2003.00420.x
IS - 10
KW - chlorhexidine
toothpaste
adult
article
bacterium colony
clinical article
colony forming unit
controlled study
dental procedure
evaluation study
gingivitis
human
mouth flora
mouth hygiene
periodontitis
rating scale
saliva
saliva analysis
tongue
tooth brushing
tooth plaque
LA - English
PY - 2003
SN - 0303-6979
SP - 919-925
ST - Effect of various chlorhexidine regimens on salivary bacteria and de novo
plaque formation
TI - Effect of various chlorhexidine regimens on salivary bacteria and de novo
plaque formation
VL - 30
ID - 14251
ER -
TY - JOUR
AB - Objective: To evaluate the effect of a pretreatment regimen that combined
meticulous mechanical tooth cleaning with the daily use of chlorhexidine (rinse,
gargle and tongue application) on de novo plaque formation and on the
recolonization of various microbiological species in plaque and saliva during a 4-
day period of no oral hygiene. Material and Methods: Ten subjects aged 24-36 years
with gingivitis were recruited. The study was designed as a double blind cross-over
clinical trial including two phases. Each experimental phase comprised one
preparatory period of 7 days and one plaque accumulation period of 4 days. During
the preparatory period, the volunteers (i) performed meticulous mechanical tooth
cleaning using toothbrush and dentifrice and (ii) were, in addition, given two
sessions of professional tooth cleaning (PTC) The final PTC was delivered after
bacterial sampling had been made on Day 0. In the Control group, no additional
plaque control measures were included. In the Test group, the participants in
addition to the mechanical measures (i) rinsed twice daily, for 60 s each time with
a 0.2% chlorhexidine solution, (ii) gargled twice daily for 10 s with the
chlorhexidine preparation, and finally (iii) brushed the dorsum of the tongue for
60 s, twice daily, with a 1.0% chlorhexidine gel. During the 4-day plaque
accumulation period, the participants abstained from all mechanical and chemical
plaque control measures. On Days 0, 1, 2 and 4 the quantity and quality of plaque
formed was assessed by clinical means and by DNA probe techniques. The microbiota
of the saliva was studied in samples obtained on Days 0 and 4. Results: It was
demonstrated that chlorhexidine used as a mouthrinse combined with gargling and
tongue application during the preparatory period significantly retarded the amount
of plaque that formed on tooth surfaces during the following 4 days of no oral
hygiene. Further, the number of microorganisms present in the biofilm representing
Days 0, 1 and 2 of the "plaque accumulation period" was apparently affected by the
use of the antiseptic. Among the microorganisms influenced by the chlorhexidine
regimen, a substantial number belonged to the genus Actinomyces. It was also
observed that the adjunctive use of chlorhexidine reduced the number of bacteria
present in saliva at the end of the preparatory period (i.e. on Day 0). After 4
days of no oral hygiene, the microbiota of the newly formed plaque in the Test and
Control groups had many features in common. Conclusion: Habitat is critical in
controlling the bacterial composition of the dental biofilm. The microbiota will
tend to go back to the one that is characteristic of a given subject, once chemical
antimicrobial means are withdrawn. © Blackwell Munksgaard, 2004.
AN - rayyan-563560861
AU - Sekino, S.
AU - Ramberg, P.
AU - Uzel, N. G.
AU - Socransky, S.
AU - Lindhe, J.
DO - 10.1111/j.1600-051X.2004.00526.x
IS - 8
chlorhexidine
DNA
Actinomyces
adult
article
biofilm
clinical article
clinical trial
controlled study
crossover procedure
dental procedure
drug effect
drug formulation
evaluation study
gargle
gel
gingivitis
human
microorganism
mouth hygiene
saliva
sampling
tongue
tooth brushing
tooth plaque
volunteer
LA - English
PY - 2004
SN - 0303-6979
SP - 609-614
ST - The effect of a chlorhexidine regimen on de novo plaque formation
TI - The effect of a chlorhexidine regimen on de novo plaque formation
VL - 31
ID - 14235
ER -
TY - JOUR
AB - In humans, one of the major factors associated with infective endocarditis
(IE) is the concurrent presence of periodontal disease (PD). However, in veterinary
medicine, the relevance of PD in the evolution of dogs' endocarditis remains poorly
understood. In order to try to establish a correlation between mouth-associated
Enterococcus spp. and infective endocarditis in dogs, the present study evaluated
the presence and diversity of enterococci in the gum and heart of dogs with PD.
Samples were collected during necropsy of 32 dogs with PD and visually diagnosed
with IE, which died of natural causes or euthanasia. Enterococci were isolated,
identified and further characterized by Pulsed-Field Gel Electrophoresis (PFGE);
susceptibility to antimicrobial agents and pathogenicity potential was also
evaluated. In seven sampled animals, PFGE-patterns, resistance and virulence
profiles were found to be identical between mouth and heart enterococci obtained
from the same dog, allowing the establishment of an association between
enterococcal periodontal disease and endocarditis in dogs. These findings represent
a crucial step towards understanding the pathogenesis of PD-driven IE, and
constitute a major progress in veterinary medicine.
AN - rayyan-563560358
AU - Semedo-Lemsaddek, T.
AU - Tavares, M.
AU - Braz, B. S.
AU - Tavares, L.
AU - Oliveira, M.
DO - 10.1371/journal.pone.0146860
IS - 1
animal tissue
article
autopsy
bacterial endocarditis
bacterium isolation
cardiovascular system examination
controlled study
disease association
dog
Enterococcus
euthanasia
female
male
mouth examination
nonhuman
periodontal disease
species diversity
LA - English
PY - 2016
SN - 1932-6203
ST - Enterococcal infective endocarditis following periodontal disease in dogs
T2 - PLoS ONE
TI - Enterococcal infective endocarditis following periodontal disease in dogs
VL - 11
ID - 13732
ER -
TY - JOUR
AN - rayyan-563561267
AU - Tavares, M.
AU - São Braz, B.
AU - Tavares, L.
AU - Oliveira, M.
DO - 10.1371/journal.pone.0146860
IS - 1
J2 - PLoS One
KW - Animals
Anti-Bacterial Agents/chemistry
Dogs
Drug Resistance, Bacterial
Electrophoresis, Gel, Pulsed-Field
Endocarditis, Bacterial/complications/*veterinary
*Enterococcus
Female
Gingiva/microbiology
Gram-Positive Bacterial Infections/*veterinary
Male
Mitral Valve/microbiology
Periodontal Diseases/complications/microbiology/*veterinary
Tricuspid Valve/microbiology
Virulence
LA - eng
N1 - Interdisciplinary Centre of Research in Animal Health (CIISA), Faculty of
Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-
477 Lisboa, Portugal.; Interdisciplinary Centre of Research in Animal Health
(CIISA), Faculty of Veterinary Medicine, University of Lisbon, Avenida da
Universidade Técnica, 1300-477 Lisboa, Portugal.; Interdisciplinary Centre of
Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of
Lisbon, Avenida da Universidade Técnica, 1300-477 Lisboa, Portugal.;
Interdisciplinary Centre of Research in Animal Health (CIISA), Faculty of
Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-
477 Lisboa, Portugal.; Interdisciplinary Centre of Research in Animal Health
(CIISA), Faculty of Veterinary Medicine, University of Lisbon, Avenida da
Universidade Técnica, 1300-477 Lisboa, Portugal.
PY - 2016
SP - e0146860
ST - Enterococcal Infective Endocarditis following Periodontal Disease in Dogs
T2 - PloS one
TI - Enterococcal Infective Endocarditis following Periodontal Disease in Dogs
VL - 11
ID - 14641
ER -
TY - JOUR
AN - rayyan-563562440
AU - Tavares, M.
AU - Sao Braz, B.
AU - Tavares, L.
AU - Oliveira, M.
DO - 10.1371/journal.pone.0146860
IS - 1
PY - 2016
SN - 1932-6203
ST - Enterococcal Infective Endocarditis following Periodontal Disease in Dogs
T2 - PLOS ONE
TI - Enterococcal Infective Endocarditis following Periodontal Disease in Dogs
VL - 11
Y2 - 1 y3 - 11
ID - 15814
ER -
TY - JOUR
AB - Aim To investigate the antimicrobial activity of 2.5% and 5.25% sodium
hypochlorite and 2.0% chlorhexidine gel and liquid as endodontic-irrigating
substances against selected single-species biofilms. Methods Single-species
biofilms of Enterococcus faecalis, Staphylococcus aureus, Candida albicans,
Prevotella intermedia, Porphyromonas gingivalis, Porphyromonas endodontalis and
Fusobacterium nucleatum were generated on a cellulose nitrate membrane placed on
agar medium. The biofilms were then immersed in the endodontic-irrigating
substances for 30 s and also for 5, 10, 15, 30 and 60 min, with and without
mechanical agitation. Sterile saline was used as control. After each time period,
the membrane filters were then transferred to tubes containing 2 mL of fresh broth
medium plus neutralizers (in order to prevent the residual action of the tested
substances). The micro-organisms were suspended using a vortex, and the inoculum
was serially diluted 10-fold. Aliquots of the dilutions were plated on 5% sheep
blood agar medium, and incubated under adequate gaseous conditions. Colony-forming
units were calculated. The samples were compared using the Friedman and Tukey test,
when necessary, at a significance level of P < 0.05. Results Mechanical agitation
promoted the effectiveness of the antimicrobial agents, resulting in less time to
eliminate the same micro-organisms, except for S. aureus with 2.5% NaOCl.
Antimicrobial agents in liquid presentation, especially 5.25% NaOCl and 2%
chlorhexidine, killed the tested micro-organisms more rapidly. Saline did not
inhibit the growth of any of the tested micro-organisms, with or without agitation,
being statistically different (P < 0.05) from NaOCl and chlorhexidine. P.
intermedia, P. gingivalis, P. endodontalis and F. nucleatum were eliminated in 30 s
by all antimicrobial agents, with our without agitation, in contrast with the
facultative and aerobe strains. Conclusions Mechanical agitation improved the
antimicrobial properties of the chemical substances tested using a biofilm model,
favouring the agents in liquid presentation, especially 5.25% NaOCl and 2%
chlorhexidine.
AN - rayyan-563562525
AU - Sena, N. T.
AU - Gomes, Bpfa
AU - Vianna, M. E.
AU - Berber, V. B.
AU - Zaia, A. A.
AU - Souza, F. J.
DO - 10.1111/j.1365-2591.2006.01161.x
IS - 11
PY - 2006
SN - ["0143-2885", "1365-2591"]
SP - 878-885
ST - In vitro antimicrobial activity of sodium hypochlorite and chlorhexidine
against selected single-species biofilms
TI - In vitro antimicrobial activity of sodium hypochlorite and chlorhexidine
against selected single-species biofilms
VL - 39
Y2 - 11
ID - 15899
ER -
TY - JOUR
AB - Polymeric material plays an important role as a matrix former in the
modulation of drug release of antimicrobial-loaded in situ forming gel (ISG) for
efficient periodontitis treatment. This study was conducted to compare three
polymers, namely bleached shellac (BS), Ethocel (EC) and Eudragit RS (ERS), as
matrix formers of doxycycline hyclate (DH)-loaded solvent exchange-induced ISG. All
prepared ISGs, except 25% EC ISG, exhibited the Newtonian flow behaviour.
Transformation from solution into matrix-like was achieved rapidly within 5 min.
Increasing the amount of these polymers extended the release of DH. DH-loaded EC
and ERS ISG systems exhibited high antimicrobial activity, and all ISGs were
effective in inhibiting the growth of Staphylococcus aureus, Escherichia coli,
Streptococcus mutans, Porphyromonas gingivalis and Candida albicans. By comparison,
the DH-loaded ERS ISG, through the solvent exchange mechanism, was found to be ease
in injection with low viscosity and sustained the release with higher
concentration, meanwhile, it also exhibited interesting in vitro degradability and
antimicrobial activities. Therefore, the DH-loaded ERS ISG exhibited a potential
use for localized periodontal drug delivery system for the treatment periodontitis.
(C) 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud
University. This is an open access article under the CC BY-NC-ND license
AN - rayyan-563562212
AU - Senarat, S.
AU - Lwin, W. W.
AU - Mahadlek, J.
AU - Phaechamud, T.
DO - 10.1016/j.jsps.2021.01.009
IS - 3
PY - 2021
SN - ["1319-0164", "2213-7475"]
SP - 252-263
ST - Doxycycline hyclate-loaded in situ forming gels composed from bleached
shellac, Ethocel, and Eudragit RS for periodontal pocket delivery
T2 - SAUDI PHARMACEUTICAL JOURNAL
TI - Doxycycline hyclate-loaded in situ forming gels composed from bleached
VL - 29
Y2 - 3
ID - 15586
ER -
TY - JOUR
AB - In situ forming gel (ISG) is relevant for periodontal pocket drug delivery
because of its local administration with sustained drug release. Various types of
25% w/w Eudragit®-based ISG in different solvents were prepared for 5% w/w
doxycycline hyclate (DH) loading. All Eudragit® types could be dissolved by N-
methyl-2-pyrrolidone (NMP), and Eudragit® RL and RS are mostly dissolved in various
types of solvent. Except for Eudragit® E, the 5% w/w DH-loaded Eudragit® solutions
using NMP as the solvent transformed into gel state or matrix-like after exposure
to phosphate buffer pH 6.8 and efficiently sustained a drug release. Eudragit® L
ISG in NMP achieved a sustained drug release for longer than 7 days. Viscosity and
injectability were increased as the concentration of Eudragit® L increased. The
15%, 20% and 25% w/w Eudragit® L exhibited up to 52%, 48% and 42% drug released at
7 days. The drug release kinetic of DH-loaded in Eudragit® L mostly conformed with
Higuchi's kinetics with Fickian diffusion. Their degradation rate was decreased as
Eudragit® L concentration increased meanwhile denser scaffolds structure was
evident. In addition, Staphylococcus aureus, Escherichia coli, and the major
pathogen of periodontitis, i.e., Porphyromonas gingivalis, were efficiently
inhibited. Thus, DH-loaded Eudragit® L ISG using NMP as a solvent showed potential
as the periodontal pocket delivery of DH for periodontitis treatment.
AN - rayyan-563559734
AU - Senarat, S.
AU - Phaechamud, T.
DO - 10.1016/j.jddst.2023.104361
syringe filter
doxycycline hyclate
eudragit
gel
aqueous solution
article
Candida albicans
controlled study
drug solubility
Escherichia coli
gingival tissue
hydrophilicity
nonhuman
periodontal pocket
phase separation
physical appearance
viscosity
water permeability
LA - English
PY - 2023
SN - 1773-2247
ST - Antisolvent Eudragit® polymers based in situ forming gel for periodontal
controlled drug delivery
TI - Antisolvent Eudragit® polymers based in situ forming gel for periodontal
controlled drug delivery
VL - 82
ID - 13108
ER -
TY - JOUR
AB - Zein is composed of nonpolar amino acids and is a water-insoluble protein
used as the matrix-forming agent of localized in situ forming gel (ISG). Therefore,
this study prepared solvent removal phase inversion zein-based ISG formulations to
load levofloxacin HCl (Lv) for periodontitis treatment using dimethyl sulfoxide
(DMSO) and glycerol formal (GF) as the solvents. Their physicochemical properties
were determined, including viscosity, injectability, gel formation, and drug
release. The topography of dried remnants after drug release was revealed using a
scanning electron microscope and X-ray computed microtomography (μCT) to
investigate their 3D structure and % porosity. The antimicrobial activities were
tested against Staphylococcus aureus (ATCC 6538), Escherichia coli ATCC 8739,
Candida albicans ATCC 10231, and Porphyromonas gingivalis ATCC 33277 with agar cup
diffusion. Increasing zein concentration or using GF as the solvent notably
enhanced the apparent viscosity and injection force of the zein ISG. However, its
gel formation slowed due to the dense zein matrix barrier’s solvent exchange: the
higher loaded zein or utilization of GF as an ISG solvent prolonged Lv release. The
SEM and μCT images revealed the scaffold of dried ISG in that their % porosity
corresponded with their phase transformation and drug release behavior. In
addition, the sustainability of drug diffusion promoted a smaller antimicrobial
inhibition clear zone. Drug release from all formulations was attained with minimum
inhibitory concentrations against pathogen microbes and exhibited a controlled
release over 7 days. Lv-loaded 20% zein ISG using GF as a solvent exhibited
appropriate viscosity, Newtonian flow, acceptable gel formation and injectability,
and prolonged Lv release over 7 days with efficient antimicrobial activities
against various test microbes; thus, it is the potential ISG formulation for
periodontitis treatment. Consequently, the Lv-loaded solvent removal zein-based
ISGs proposed in this investigation offer promising potential as an efficacious
drug delivery system for periodontitis treatment by local injection.
AN - rayyan-563559732
AU - Senarat, S.
AU - Rojviriya, C.
AU - Puyathorn, N.
AU - Phaechamud, T.
IS - 4
KW - Cary 60
electronic spreadsheet
dimethyl sulfoxide
DNA topoisomerase (ATP hydrolysing)
doxycycline hyclate
glycerol formal
levofloxacin
myristic acid isopropyl ester
polycaprolactone
vancomycin
agar diffusion
article
Candida albicans
drug diffusion
drug formulation
drug release
Escherichia coli
human
hydrophilicity
periodontitis
physical chemistry
shear stress
solvent extraction
viscosity
atridox
Excel (software)
SPSS
LA - English
PY - 2023
SN - 1999-4923
ST - Levofloxacin HCl-Incorporated Zein-Based Solvent Removal Phase Inversion In
Situ Forming Gel for Periodontitis Treatment
T2 - Pharmaceutics
TI - Levofloxacin HCl-Incorporated Zein-Based Solvent Removal Phase Inversion In
Situ Forming Gel for Periodontitis Treatment
VL - 15
ID - 13106
ER -
TY - JOUR
AB - A drug delivery system based on an aqueous-induced in situ forming gel (ISG)
consists of solubilizing the drug within an organic solution of a polymer using a
biocompatible organic solvent. Upon contact with an aqueous medium, the solvent
diffuses out and the polymer, designed to be insoluble in water, solidifies and
transforms into gel. Nitrocellulose (Nc), an aqueous insoluble nitrated ester of
cellulose, should be a promising polymer for an ISG using water induction of its
solution to gel state via phase inversion. The aim of this investigation was to
develop and evaluate a moxifloxacin HCl (Mx)-incorporated aqueous-induced Nc-based
ISG for periodontitis treatment. The effects of different solvents (N-methyl
pyrrolidone (NMP), DMSO, 2-pyrrolidone (Py), and glycerol formal (Gf)) on the
physicochemical and bioactivity properties of the ISGs were investigated. The
viscosity and injection force of the ISGs varied depending on the solvent used,
with Gf resulting in higher values of 4631.41 ± 52.81 cPs and 4.34 ± 0.42 N,
respectively. All ISGs exhibited Newtonian flow and transformed into a gel state
upon exposure to the aqueous phase. The Nc formulations in DMSO showed lower water
tolerance (12.50 ± 0.72%). The developed ISGs were easily injectable and
demonstrated water sensitivity of less than 15.44 ± 0.89%, forming a gel upon
contact with aqueous phase. The transformed Nc gel effectively prolonged Mx release
over two weeks via Fickian diffusion, with reduced initial burst release. Different
solvent types influenced the sponge-like 3D structure of the dried Nc ISGs and
affected mass loss during drug release. Incorporating Nc reduced both solvent and
drug diffusion, resulting in a significantly narrower zone of bacterial growth
inhibition (p < 0.05). The Mx-incorporated Nc-based ISGs exhibited efficient
antibacterial activity against four strains of Staphylococcus aureu and against
periodontitis pathogens including Aggregatibacter actinomycetemcomitans and
Porphyromonas gingivalis. This study suggests that the developed Mx-incorporated
Nc-based ISGs using DMSO and NMP as the solvents are the most promising
formulations. They exhibited a low viscosity, ease of injection, and rapid
transformation into a gel upon aqueous induction, and they enabled localized and
prolonged drug release with effective antibacterial properties. Additionally, this
study represents the first reported instance of utilizing Nc as the polymer for
ISG. Further clinical experiments are necessary to evaluate the safety of this ISG
formulation.
AN - rayyan-563561240
AU - Senarat, S.
AU - Rojviriya, C.
AU - Sarunyakasitrin, K.
AU - Charoentreeraboon, J.
AU - Phaechamud, T.
DO - 10.3390/gels9070572
IS - 7
J2 - Gels
LA - eng
University, Nakhon Pathom 73000, Thailand.; Synchrotron Light Research Institute,
Mueang District, Nakhon Ratchasima 30000, Thailand.; Secretary Office of Faculty,
Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.;
Pharmaceutical Intellectual Center "Prachote Plengwittaya", Faculty of Pharmacy,
Silpakorn University, Nakhon Pathom 73000, Thailand.; Department of Industrial
Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000,
Thailand.; Natural Bioactive and Material for Health Promotion and Drug Delivery
System Group (NBM), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000,
Thailand.; Department of Pharmaceutical Technology, Faculty of Pharmaceutical
Sciences, Prince of Songkla University, Songkhla 90110, Thailand.; Programme of
Pharmaceutical Engineering, Faculty of Pharmacy, Silpakorn University, Nakhon
Pathom 73000, Thailand.; Department of Industrial Pharmacy, Faculty of Pharmacy,
Silpakorn University, Nakhon Pathom 73000, Thailand.
PY - 2023
ST - Moxifloxacin HCl-Incorporated Aqueous-Induced Nitrocellulose-Based In Situ
Gel for Periodontal Pocket Delivery
TI - Moxifloxacin HCl-Incorporated Aqueous-Induced Nitrocellulose-Based In Situ
Gel for Periodontal Pocket Delivery
VL - 9
Y2 - 7 y3 - 13
ID - 14614
ER -
TY - JOUR
AB - Solvent exchange-induced in situ forming gel (ISG) is currently an appealing
dosage form for periodontitis treatment via localized injection into the
periodontal pocket. This study aims to apply Eudragit L and Eudragit S as matrix
components of ISG by using monopropylene glycol as a solvent for loading
levofloxacin HCl for periodontitis treatment. The influence of Eudragit
concentration was investigated in terms of apparent viscosity, rheological
behavior, injectability, gel-forming behavior, and mechanical properties. Eudragit
L-based formulation presented less viscosity, was easier to inject, and could form
more gel than Eudragit S-based ISG. Levofloxacin HCl-loading diminished the
viscosity of Eudragit L-based formulation but did not significantly change the gel
formation ability. Higher polymer loading increased viscosity, force-work of
injectability, and hardness. SEM photographs and µCT images revealed their scaffold
formation, which had a denser topographic structure and less porosity attained
owing to higher polymer loading and less in vitro degradation. By tracking with
fluorescence dyes, the interface interaction study revealed crucial information
such as solvent movement ability and matrix formation of ISG. They prolonged the
drug release for 14 days with fickian drug diffusion kinetics and increased the
release amount above the MIC against test microbes. The 1% levofloxacin HCl and 15%
Eudragit L dissolved in monopropylene glycol (LLM15) was a promising ISG because of
its appropriate viscosity (3674.54 ± 188.03 cP) with Newtonian flow, acceptable gel
formation and injectability (21.08 ± 1.38 N), hardness (33.81 ± 2.3 N) and
prolonged drug release with efficient antimicrobial activities against S. aureus
(ATCC 6538, 6532, and 25923), methicillin-resistant S. aureus (MRSA) (S. aureus
ATCC 4430), E. coli ATCC 8739, C. albicans ATCC 10231, P. gingivalis ATCC 33277,
and A. actinomycetemcomitans ATCC 29522; thus, it is the potential ISG formulation
for periodontitis treatment by localized periodontal pocket injection.
AN - rayyan-563561344
AU - Senarat, S.
AU - Rojviriya, C.
AU - Phaechamud, T.
AU - Chantadee, T.
DO - 10.3390/gels9070583
IS - 7
J2 - Gels
LA - eng
University, Nakhon Pathom 73000, Thailand.; Pharmaceutical Intellectual Center
"Prachote Plengwittaya", Faculty of Pharmacy, Silpakorn University, Nakhon Pathom
73000, Thailand.; Program of Pharmaceutical Technology, Department of
Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom
73000, Thailand.; Synchrotron Light Research Institute, Mueang District, Nakhon
Ratchasima 30000, Thailand.; Programme of Pharmaceutical Engineering, Faculty of
Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.; Program of
Pharmaceutical Technology, Department of Pharmaceutical Technology, Faculty of
Pathom 73000, Thailand.; Department of Pharmaceutical Sciences, Faculty of
Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.; Center of Excellent
in Pharmaceutical Nanotechnology, Chiang Mai University, Chiang Mai 50200,
Thailand.
PY - 2023
ST - Levofloxacin HCl-Loaded Eudragit L-Based Solvent Exchange-Induced In Situ
Forming Gel Using Monopropylene Glycol as a Solvent for Periodontitis Treatment
TI - Levofloxacin HCl-Loaded Eudragit L-Based Solvent Exchange-Induced In Situ
Forming Gel Using Monopropylene Glycol as a Solvent for Periodontitis Treatment
VL - 9
Y2 - 7 y3 - 18
ID - 14718
ER -
TY - JOUR
AB - Polymeric material plays an important role as a matrix former in the
modulation of drug release of antimicrobial-loaded in situ forming gel (ISG) for
efficient periodontitis treatment. This study was conducted to compare three
polymers, namely bleached shellac (BS), Ethocel (EC) and Eudragit RS (ERS), as
matrix formers of doxycycline hyclate (DH)-loaded solvent exchange-induced ISG. All
prepared ISGs, except 25% EC ISG, exhibited the Newtonian flow behaviour.
Transformation from solution into matrix-like was achieved rapidly within 5 min.
Increasing the amount of these polymers extended the release of DH. DH-loaded EC
and ERS ISG systems exhibited high antimicrobial activity, and all ISGs were
effective in inhibiting the growth of Staphylococcus aureus, Escherichia coli,
Streptococcus mutans, Porphyromonas gingivalis and Candida albicans. By comparison,
the DH-loaded ERS ISG, through the solvent exchange mechanism, was found to be ease
in injection with low viscosity and sustained the release with higher
concentration, meanwhile, it also exhibited interesting in vitro degradability and
antimicrobial activities. Therefore, the DH-loaded ERS ISG exhibited a potential
use for localized periodontal drug delivery system for the treatment periodontitis.
AN - rayyan-563560018
AU - Senarat, S.
AU - Wai Lwin, W.
AU - Mahadlek, J.
AU - Phaechamud, T.
DO - 10.1016/j.jsps.2021.01.009
IS - 3
doxycycline hyclate
ethyl cellulose
eudragit rs
gel
shellac
absorption lag time
article
Candida albicans
controlled study
drug degradation
drug release
Escherichia coli
freeze drying
human
in vitro study
nonhuman
patient compliance
periodontal pocket
pH
pore size
shear rate
shear stress
viscoelasticity
viscosity
LA - English
PY - 2021
SN - 1319-0164
SP - 252-263
ST - Doxycycline hyclate-loaded in situ forming gels composed from bleached
T2 - Saudi Pharm. J.
TI - Doxycycline hyclate-loaded in situ forming gels composed from bleached
VL - 29
ID - 13392
ER -
TY - JOUR
AB - The accessibility of the oral cavity makes application of drugs easy and
acceptable to the patient, while permitting easy removal in the event of adverse
reactions. Drugs penetrating the oral mucosa can be delivered systemically via
direct entry into the systemic circulation thus avoiding the hepatic first-pass
effect and degradation in the gastrointestinal tract. Due to the low permeability
of the oral mucosa, new strategies are needed to improve the delivery of drugs
across the mucosa. In order to improve the availability of drugs across the oral
mucosa, mucoadhesive systems are applied to prolong the retention time of the
delivery system on the mucosa. Furthermore, availability can be improved by using
permeation enhancers. Chitosan with its favorable properties such as bioadhesivity,
biodegradability, biocompatibility and permeation enhancing activity, offers great
advantages over other polymers that are used for oral mucosal delivery. A wide
choice of chitosan delivery systems such as solutions, gels, sponges, films,
fibers, tablets and micro-Inanoparticles have been shown to be capable of
delivering drugs into the oral cavity as well as across the oral mucosa. In this
review, applications of chitosan for oral mucosal delivery will be reviewed and the
possibilities and limitations discussed.
AN - rayyan-563560652
AU - Şenel, S.
DO - 10.1016/S1773-2247(10)50003-0
IS - 1
KW - bromocriptine mesilate
bupivacaine
chitin
chitosan
chitosan chloride
chitosan derivative
chlorhexidine acetate
denbufylline
flavonoid
gelatin sponge
ginsenoside
glucosamine
hydrocortisone
lysozyme
macrogol
miconazole
nanoparticle
nicotine
nystatin
ornidazole
polymer
polyvinyl alcohol
povidone
recombinant protein
taurine
unclassified drug
unindexed drug
antiviral activity
aphthous stomatitis
biocompatibility
biodegradability
bone matrix
buccal mucosa
drug activity
drug penetration
drug retention
drug transport
fiber
first pass effect
gel
human
immunogenicity
intestine mucosa
molecular weight
mouth cavity
mouth mucosa
mucoadhesion
mucosa inflammation
nonhuman
nose mucosa
periodontal disease
review
tablet
tissue regeneration
tobacco dependence
vagina mucosa
wound healing
LA - English
PY - 2010
SN - 1773-2247
SP - 23-32
ST - Potential applications of chitosan in oral mucosal delivery
TI - Potential applications of chitosan in oral mucosal delivery
VL - 20
ID - 14026
ER -
TY - JOUR
AB - BACKGROUND: Dental biofilm harboring oral bacteria is highly correlated with
the progression of dental diseases. The existence of micro organisms as polyspecies
in an oral biofilm and dental plaque has profound implications for the etiology of
periodontal disease. The adhesion of streptococci to the tooth surface is the first
step in the formation of dental plaque. Antiadhesive agents which can disrupt the
biofilm formation can be an effective alternative to antibacterial therapy.
MATERIALS AND METHODS: A total of 10 patients both male and female between the age
group of 20-40 years were included in the study. Plaque samples were taken and
subjected to culturing on rabbit's blood agar plate for the growth of streptococci
colonies for 24-48 h. The streptococci colonies were identified and was further
subjected to subculturing for 24-48 h with disc containing ethyl alcohol+cranberry
extract (Group A) and water+cranberry extract (Group B). Both these groups A and B
were further divided into subgroups I, II, III, IV, and V according to
concentration 1:2, 1:4, 1:40, 1:100 and 1:600 respectively. RESULTS: Zone of
inhibition of Group A with subgroup I disc was 2 mm. while with subgroups II, III,
IV, V disc was 4mm. Whereas the zone of inhibition seen of Group B was same (2mm)
in subgroups I, II, III, IV discs however a significant zone of inhibition (10mm)
was observed in subgroup V disc. CONCLUSION: CRANBERRY JUICE (ACTIVE INGREDIENT:
Non dialyzable material) inhibits the adhesion and reverses the coaggregation of
various oral micro organisms. The present study revealed that cranberry gel in
highly concentrated (1:600) form has an inhibitory effect on the colonization of
the streptococci species, and thus can be beneficial in the inhibition of dental
plaque formation.
AN - rayyan-563561392
AU - Sethi, R.
AU - Govila, V.
DO - 10.4103/0972-124X.82271
IS - 1
LA - eng
N1 - Department of Periodontics, U.P. Dental College and Research Centre, Lucknow,
Uttar Pradesh, India.
PY - 2011
SP - 46-50
ST - Inhibitory effect of cranberry juice on the colonization of Streptococci
species: An in vitro study
TI - Inhibitory effect of cranberry juice on the colonization of Streptococci
species: An in vitro study
VL - 15
Y2 - 1
ID - 14766
ER -
TY - JOUR
AN - rayyan-563561632
AU - Sethiya, K. R.
AU - Dhadse, P.
AU - Bajaj, P.
AU - Chimote, M.
AU - Subhadarsanee, C.
AU - Hassan, S.
DO - 10.4103/jdmimsu.jdmimsu_385_21
IS - 4
PY - 2021
SP - 728-733
ST - Comparative evaluation of the effectiveness of sodium hypochlorite and
chlorhexidine in one-stage full-mouth disinfection treatment of patients with
generalized aggressive periodontitis: A randomized controlled clinical trial
T2 - Journal of Datta Meghe Institute of Medical Sciences University
TI - Comparative evaluation of the effectiveness of sodium hypochlorite and
chlorhexidine in one-stage full-mouth disinfection treatment of patients with
generalized aggressive periodontitis: A randomized controlled clinical trial
85133697987&doi=10.4103%2fjdmimsu.jdmimsu_385_21&partnerID=40&md5=b4247cdae67a40e36
67ab1da5ab716ce
VL - 16
ID - 15006
ER -
TY - JOUR
AB - The periodontal pathogen Tannerella forsythia has the unique ability to
produce methylglyoxal (MGO), an electrophilic compound which can covalently modify
amino acid side chains and generate inflammatory adducts known as advanced
glycation endproducts (AGEs). In periodontitis, concentrations of MGO in gingival-
crevicular fluid are increased and are correlated with the T. forsythia load.
However, the source of MGO and the extent to which MGO may contribute to
periodontal inflammation has not been fully explored. In this study we identified a
functional homolog of the enzyme methylglyoxal synthase (MgsA) involved in the
production of MGO in T. forsythia. While wild-type T.forsythia produced a
significant amount of MGO in the medium, a mutant lacking this homolog produced
little to no MGO. Furthermore, compared with the spent medium of the T. forsythia
parental strain, the spent medium of the T. forsythia mgsA-deletion strain induced
significantly lower nuclear factor-kappa B activity as well as proinflammogenic and
pro-osteoclastogenic cytokines from THP-1 monocytes. The ability of T. forsythia to
induce protein glycation endproducts via MGO was confirmed by an electrophoresis-
based collagen chain mobility shift assay. Together these data demonstrated that T.
forsythia produces MGO, which may contribute to inflammation via the generation of
AGEs and thus act as a potential virulence factor of the bacterium.
AN - rayyan-563560245
AU - Settem, R. P.
AU - Honma, K.
AU - Shankar, M.
AU - Li, M.
AU - LaMonte, M.
AU - Xu, D.
AU - Genco, R. J.
AU - Browne, R. W.
AU - Sharma, A.
DO - 10.1111/omi.12224
IS - 4
KW - advanced glycation end product
advanced glycation end product receptor
bacterial enzyme
high mobility group B1 protein
interleukin 10
interleukin 1beta
interleukin 6
methylglyoxal
methylglyoxal synthase
phosphatase
secreted embryonic alkaline phosphatase
synthetase
unclassified drug
article
bacterial load
bacterial strain
bacterial virulence
controlled study
cytokine release
deletion mutant
human
human cell
immunogenicity
inflammation
MAPK signaling
monocyte
mutant
nonhuman
osteoclastogenesis
protein degradation
protein function
protein glycosylation
THP-1 cell line
wild type
LA - English
PY - 2018
SN - ["2041-1014", "2041-1006"]
SP - 292-299
ST - Tannerella forsythia-produced methylglyoxal causes accumulation of advanced
glycation endproducts to trigger cytokine secretion in human monocytes
TI - Tannerella forsythia-produced methylglyoxal causes accumulation of advanced
glycation endproducts to trigger cytokine secretion in human monocytes
VL - 33
ID - 13619
ER -
TY - GEN
AN - rayyan-563559782
AU - Seymour, G. J.
AU - Cullinan, M. P.
AU - Heng, N. C. K.
AU - Cooper, P. R.
KW - antioxidant
biological marker
dental material
gelatin
proteome
RNA
trace element
bacterium adherence
biofilm
bioinformatics
bone regeneration
cancer patient
cell culture
circulating tumor cell
colorectal cancer
CRISPR-CAS9 system
data analysis
deacetylation
dental health
dentistry
editorial
exosome
gene editing
histone acetylation
human
immunofluorescence
in vitro study
keratinocyte
machine learning
mass spectrometry
microbial community
microbial genome
molecular biology
mouth flora
neutrophil extracellular trap
omics
osteoblast
oxidative stress
pathogenesis
periodontal disease
RNA analysis
RNA sequencing
saliva
Streptococcus
tissue engineering
tooth pulp
LA - English
PY - 2023
SN - ["1940-6029", "1064-3745"]
SP - v
ST - Preface
T2 - Methods Mol. Biol.
TI - Preface
VL - 2588
ID - 13156
ER -
TY - JOUR
AB - Background: Postoperative complications occur after periodontal plastic
surgeries, but an ideal treatment to overcome them has not been found yet. Aims: To
evaluate the effects of topically applied Oral-norm gel on the healing of
excisional wounds. Study Design: Animal experiment. Methods: Excisional wounds with
a diameter of 3 mm were made in the center of the palatal mucosa of 63 Sprague
Dawley rats. Seven animals were sacrificed at time 0. The remaining rats were
divided into two groups: a test group in which the topical Oral-norm gel was
applied three times a day and a control group in which nothing was applied. Seven
animals in each group were sacrificed at 3, 7, 14, and 21 days. Mean wound surface
area was measured photographically, while wound healing and width were evaluated
microscopically. Results: The mean wound surface area decreased significantly after
3 days in both groups (p<0.001). Between days 3 and 7, the mean wound surface area
decreased from 6.62 (2.85) to 0.83 (1.62) mm2 in the control group and 5.07 (0.88)
to 1.42 (1.67) mm2 in the test group. The wound width decreased significantly on
day 7 in both groups (p<0.001), with no further changes by day 14. Both groups had
a significant increase in inflammation and vascularization on day 3 (p<0.001), with
a reduction thereafter. No significant differences in macroscopic and microscopic
measurements were observed between the groups at any time point (p>0.05).
Conclusion: The Oral-norm gel has no positive healing effects in the palatal mucosa
of rats.
AN - rayyan-563560206
AU - Sezgin, Y.
AU - Çetin, M. B.
AU - Bulut, Ş
AU - Alptekin, N. Ö
AU - Börçek, P.
DO - 10.4274/balkanmedj.galenos.2018.2018.0167
IS - 2
KW - 10 undecenoic acid
dexpanthenol
lidocaine
natural product
oral norm gel
silbiol
unclassified drug
animal experiment
animal model
animal tissue
article
buccal mucosa
controlled study
drug effect
excision
female
histology
inflammation
microscopy
morphometry
nonhuman
rat
rat model
Sprague Dawley rat
surface area
vascularization
wound healing
LA - English
PY - 2019
SN - ["2146-3131", "2146-3123"]
SP - 88-95
ST - Evaluating the effects of a topical preparation with dexpanthenol, silbiol,
undecylenic acid, and lidocaine on palatal mucosa wound healing in a rat model
T2 - Balkan Med. J.
TI - Evaluating the effects of a topical preparation with dexpanthenol, silbiol,
undecylenic acid, and lidocaine on palatal mucosa wound healing in a rat model
VL - 36
ID - 13580
ER -
TY - JOUR
AB - Propolis is a resinous material collected by bees from bud and exudates of
the plants, mixed with bee enzymes, pollen and wax. In this review, the biological
properties of propolis and some therapeutic applications are discussed. The same
biological activities have been investigated until today, using samples from
different geographic regions. Thus, the study of the biological properties of a
given sample should always be associated with its chemical composition and
botanical source, representing a particular sample of a given geographic area,
exploring its biological potential and the role of its constituents. Efforts have
been carried out to explain propolis' mechanisms of action in vivo and in vitro,
but the majority of propolis' targets and actions are still unclear. The number of
formulations containing propolis and patents have increased, although propolis
extracts have been used deliberately with different recommendations, not always
mentioning the chemical composition, vegetal source and the methods of extraction.
Clinical studies will help to obtain criterious recommendations in view of the
expected outcomes. Further investigation should explore the effects of common
compounds found in the samples from all over the world in an attempt to standardize
the research on propolis and to obtain new drugs.
AN - rayyan-563560343
AU - Sforcin, J. M.
DO - 10.1002/ptr.5605
IS - 6
KW - chlorhexidine
mouthwash
nanoparticle
propolis
dental caries
depression
drug activity
drug formulation
drug mechanism
drug research
gel
geography
gingivitis
human
immunomodulation
in vitro study
in vivo study
mental disease
nonhuman
patent
review
standardization
vagina candidiasis
wound healing
LA - English
PY - 2016
SN - ["1099-1573", "0951-418X"]
SP - 894-905
ST - Biological Properties and Therapeutic Applications of Propolis
TI - Biological Properties and Therapeutic Applications of Propolis
VL - 30
ID - 13717
ER -
TY - JOUR
AB - The aim of this study was to find the antibacterial potential of curcumin
against Porphyromonas gingivalis and connective tissue responses to curcumin gel in
the subcutaneous tissue of rats. The sample consisted of subgingival plaque
collected from patients with chronic periodontitis. The P. gingivalis clinically
isolated strain was confirmed by anaerobic culture, morphology, biochemical tests
(Vitek ANC Kit), and PCR (16S rDNA). Minimum inhibitory concentration (MIC) and
minimum bactericidal concentration (MBC) were determined by incubation of twofold
serial dilution of broth media containing curcumin (from 100 to 0.05 μg/ml) for 48
h at 37°C. Fifteen adult Wistar rats (3-4 months old) were used and randomly
divided into three groups (negative control, positive control, and experimental
groups). Tubes were implanted on the back skin (45 tubes). Rats were euthanized at
7, 30, and 60 days after surgical processes, and then the samples were taken and
processed to achieve conventional hematoxylin and eosin-stained slides. The MIC and
MBC of curcumin against clinically isolated P. gingivalis were 12 μg/ml. Curcumin
gel caused moderate inflammatory reactions at 7 and 30 days, while at 60 days, it
caused dramatic decline and resulted in a nonsignificant response. Besides,
curcumin gel stimulated quick reepithelialization, fibroblast proliferation, and
scarring through the formation of thick bundles of well-organized collagen fibers.
Curcumin has an effective antibacterial action against clinically isolated P.
gingivalis at low concentration (12 μg/ml), and it was regarded as the
biocompatible material in the subcutaneous tissues.
AN - rayyan-563560215
AU - Sha, A. M.
AU - Garib, B. T.
DO - 10.1155/2019/6810936
KW - curcumin
tetracycline
adult
animal cell
animal experiment
animal model
animal tissue
article
bacterium colony
cell proliferation
collagen fiber
connective tissue
controlled study
epithelization
fibroblast
gel
histopathology
inflammatory cell
male
nonhuman
periodontal pocket
rat
scar formation
subcutaneous tissue
LA - English
PY - 2019
SN - ["2314-6141", "2314-6133"]
ST - Antibacterial Effect of Curcumin against Clinically Isolated Porphyromonas
gingivalis and Connective Tissue Reactions to Curcumin Gel in the Subcutaneous
Tissue of Rats
TI - Antibacterial Effect of Curcumin against Clinically Isolated Porphyromonas
gingivalis and Connective Tissue Reactions to Curcumin Gel in the Subcutaneous
Tissue of Rats
VL - 2019
ID - 13589
ER -
TY - JOUR
AB - BackgroundTo assess the antibacterial activity of multi-strain probiotics
supernatants (MSP); Lactobacillus plantarum, Lactobacillus rhamnosus, and
Lactobacillus acidophilus as an intracanal medication on Enterococcus faecalis (E.
faecalis) biofilm in a tooth model.MethodsSixty extracted human single-rooted teeth
with single canals were instrumented, sterilized, and inoculated with E. faecalis.
After 21 days of incubation, four specimens were randomly selected to validate the
biofilm formation by scanning electron microscope (SEM). The remaining specimens
were randomly divided (n = 14), according to the intracanal medication (ICM)
received into: Ca(OH)(2): calcium hydroxide paste (35% Ultra Cal XS Ca(OH)(2)),
Probiotics supernatants: MSP in poloxamer gel vehicle Poloxamer: poloxamer gel
vehicle and, Control: E. faecalis biofilm only. The tested groups were further
subdivided into two equal subgroups (n = 7) according to the incubation period (24
h and 7 days). Shaved dentin chips were obtained and collected by H-files and paper
points, respectively for bacterial culture. The antibacterial activity was assessed
after each incubation period quantitatively and qualitatively using bacterial
colony-forming units per milliliter (CFUs/ml) and SEM, respectively.ResultsThe
lowest CFUs/ml was found in Ca (OH)(2) with a significant difference compared to
other groups after 24 h. After 7 days, a similar outcome was found with a further
significant reduction of CFUs/ml in all groups with no statistical difference
between Ca(OH)(2) and probiotics supernatants groups. Ca (OH)(2) and Probiotics
supernatants groups showed a significant (p < 0.05) percentage of overall bacterial
reduction (100.00 +/- 0.00% and 70.30 +/- 12.95%, respectively) compared to
poloxamer and control groups (27.80 +/- 14.45 and 28.29 +/- 19.79). SEM images
showed a bacteria-free state in the Ca(OH)(2) group after 7 days while few bacteria
were found in the probiotics supernatants group. An extensive invasion of bacteria
was found in poloxamer and controls groups.ConclusionMSP has a potential
antibacterial effect on E. faecalis growth closely similar to the routinely used Ca
(OH)(2).
AN - rayyan-563562507
AU - Shaaban, S.
AU - Genena, S.
AU - Elraggal, A.
AU - Hamad, G. M.
AU - Meheissen, M. A.
AU - Moussa, S.
DO - 10.1186/s12903-023-02914-2
IS - 1
PY - 2023
SN - 1472-6831
ST - Antibacterial effectiveness of multi-strain probiotics supernatants
intracanal medication on Enterococcus faecalis biofilm in a tooth model
TI - Antibacterial effectiveness of multi-strain probiotics supernatants
intracanal medication on Enterococcus faecalis biofilm in a tooth model
VL - 23
Y2 - 4 y3 - 20
ID - 15881
ER -
TY - JOUR
AN - rayyan-563560647
AU - Shabahang, S.
DO - 10.1016/j.joen.2010.01.019
IS - 4
chlorhexidine
citric acid
doxycycline
MTAD (intracanal irrigant)
polysorbate
bacterium
drug effect
human
letter
LA - English
PY - 2010
SN - 0099-2399
SP - 596
Medication in Teeth with Apical Periodontitis
T2 - J. Endod.
Medication in Teeth with Apical Periodontitis
VL - 36
ID - 14021
ER -
TY - JOUR
AB - Chlorhexidine gluconate mucoadhesive films and gels of chitosan, carbopol
934P and hydroxy propyl methylcellulose were formulated in different concentrations
for treatment of periodontal diseases. They were evaluated for compatibility, drug
content, antibacterial activity against Escherichia coli, and Staphylococci aureus
and in vitro release studies. In vitro release studies for films showed a higher
rate of drug release for HPMC films compared to chitosan films. The in vitro
diffusion studies were carried out for gels using dialysis membrane in phosphate
buffer pH 6.8 for 7 h. chlorhexidine gluconate carbopol-934P gels showed higher
rate of drug release (81.91% and 71.03%) compared to chitosan gels (57.79% and
47.97%). Bacteriological studies revealed that all formulations showed
antibacterial activity. It may be concluded, that chlorhexidine gluconate
mucoadhesive gel and film can be formulated as potential prolonged release
formulation for treatment of periodontal diseases which is more site specific and
can avoid large oral dose.
AN - rayyan-563560777
AU - Shafiullah, D.
AU - Kumar, P. T. M.
AU - Shivakumar, H. G.
IS - 2
KW - carbomer
chitosan
chlorhexidine
methylcellulose
phosphate
propane
dialysis membrane
diffusion
drug release
Escherichia coli
in vitro study
mucoadhesion
periodontal disease
pH
Staphylococcus
LA - English
PY - 2006
SN - 0019-462X
SP - 122-125
ST - Formulation and evaluation of Chlorhexidine Mucoadhesive drug delivery
systems
T2 - Indian Drugs
TI - Formulation and evaluation of Chlorhexidine Mucoadhesive drug delivery
systems
VL - 43
ID - 14151
ER -
TY - JOUR
AB - Objectives: Endoplasmic reticulum (ER) stress is one of the key mechanisms
contributing to Parkinson’s disease (PD) pathology. Pathways triggered by ER stress
are protective at early stages and initiate apoptosis when the damage is extensive.
Methods: We have previously reported that oxyresveratrol rescues cells from
oxidative stress and apoptosis in a cell culture model of PD. The aim of this study
was to investigate whether the neuroprotective mechanism of oxyresveratrol extends
to PD-associated ER stress. For this purpose, we employed two cellular models; to
induce severe ER stress, Mes23.5 cells were treated with 6-hydroxydopamine (6-OHDA)
and for ER stress driven by chaperones, human neuroblastoma cells were stably
transfected to overexpress familial mutants of α-synuclein (α-syn). Results: Our
results indicate that oxyresveratrol exhibits distinct modes of protection in both
models. In the 6-OHDA model, it inhibited the transcription of activating
transcription factor 4 (ATF4), which controls the fate of pro-apoptotic proteins.
On the other hand, in the α-syn model, oxyresveratrol suppressed mutant A30P
oligomer formation, thereby facilitating a reduction of the ER-chaperone, 78-kDa
glucose-regulated protein (Grp78). Discussion: In summary, oxyresveratrol is
protective against ER stress induced by two different triggers of PD. Owing to its
wide range of defense mechanisms, oxyresveratrol is an ideal candidate for a
multifactorial disease like PD.
AN - rayyan-563560058
AU - Shah, A.
AU - Chao, J.
AU - Legido-Quigley, C.
AU - Chang, R. C. C.
DO - 10.1080/1028415X.2019.1613764
IS - 3
KW - culture medium
guiding catheter
incubator
lactate dehydrogenase test kit
microwell plate
spectrophotometer
X ray film
alpha synuclein
carbon dioxide
chaperone
dimethyl sulfoxide
endoplasmic reticulum chaperone BiP
hygromycin B
initiation factor 2
lipofectamine
oxidopamine
oxyresveratrol
polyvinylidene fluoride
resveratrol
streptomycin
transcription factor 4
trometamol
tunicamycin
unclassified drug
animal cell
apoptosis
article
cancer model
cell culture
controlled study
cytotoxicity
defense mechanism
endoplasmic reticulum stress
enzyme assay
experimental parkinsonism
fetal bovine serum
gene expression
glioma cell
glycosylation
human
human cell
IC50
MES23.5 cell line
mesencephalic tissue
metabolomics
MTT assay
N18TG2 cell line
nerve degeneration
neuroblastoma cell
neuroprotection
nonhuman
oxidative stress
Parkinson disease
periodontitis
plasmid
protein expression
protein homeostasis
SH-SY5Y cell line
Western blotting
LA - English
PY - 2021
SN - ["1476-8305", "1028-415X"]
SP - 181-196
ST - Oxyresveratrol exerts ATF4- and Grp78-mediated neuroprotection against
endoplasmic reticulum stress in experimental Parkinson’s disease
T2 - Nutr. Neurosci.
TI - Oxyresveratrol exerts ATF4- and Grp78-mediated neuroprotection against
endoplasmic reticulum stress in experimental Parkinson’s disease
VL - 24
ID - 13432
ER -
TY - JOUR
AB - Lipids have been used extensively for drug delivery in various forms such as
liposomes, and solid-matrices. The focus of this review is evaluation of liquid
crystalline cubic phases, spontaneously formed when amphiphilic lipids are placed
in aqueous environment, for drug delivery. Cubic phases have an interesting
thermodynamically stable structure consisting of curved bicontinuous lipid bilayer
in three dimensions, separating two congruent networks of water channels. The
unique structure of cubic phase has been extensively studied using various
spectroscopic techniques and their resemblance to biomembranes has prompted many
scientists to study behavior of proteins in cubic phases. The ability of cubic
phase to incorporate and control release of drugs of varying size and polar
characteristics, and biodegradability of lipids make it an interesting drug
delivery system for various routes of administration. Cubic phases have been shown
to deliver small molecule drugs and large proteins by oral and parenteral routes in
addition to local delivery in vaginal and periodontal cavity. A number of different
proteins in cubic phase appear to retain their native conformation and bioactivity,
and are protected from chemical and physical inactivation perhaps due to the
reduced activity of water and biomembrane-like structure of cubic phase. Release of
drugs from cubic phase typically show diffusion controlled release from a matrix as
indicated by Higuchi's square root of time release kinetics. Incorporation of drug
in cubic phase can cause phase transformation to lamellar or reversed hexagonal
phase depending on the polarity and concentration of the drug, which may affect the
release profile. Biodegradability, phase behavior, ability to deliver drugs of
varying sizes and polarity and the ability to enhance the chemical and/or physical
stability of incorporated drugs and proteins make the cubic phase gel an excellent
candidate for use as a drug delivery matrix. However, shorter release duration and
the extremely high viscosity may limit its use to specific applications such as
periodontal, mucosal, vaginal and short acting oral and parenteral drug delivery. ©
2001 Elsevier Science B.V.
AN - rayyan-563560922
AU - Shah, J. C.
AU - Sadhale, Y.
AU - Chilukuri, D. M.
DO - 10.1016/S0169-409X(01)00108-9
IS - 2
KW - amphiphilic lipid
amphophile
cefazolin
cefuroxime
human insulin
pig insulin
insulin
unclassified drug
aqueous solution
drug degradation
glucose blood level
lipid bilayer
membrane
physical chemistry
priority journal
protein conformation
protein interaction
protein stability
review
humulin
iletin i
iletin ii
LA - English
PY - 2001
SN - 0169-409X
SP - 229-250
ST - Cubic phase gels as drug delivery systems
TI - Cubic phase gels as drug delivery systems
VL - 47
ID - 14296
ER -
TY - JOUR
AB - BACKGROUND: Hyaluronan is a critical component of the extracellular matrix
and contributes significantly to tissue hydrodynamics and cell migration and
proliferation. Studies have demonstrated its anti-inflammatory, antibacterial, and
regenerative effects. The present study aimed to assess the clinical effects of the
subgingival application of 0.8% hyaluronic acid gel as an adjunct to scaling and
root planing (SRP) in the treatment of generalized chronic periodontitis. MATERIALS
AND METHODS: Patients with chronic periodontitis were recruited to participate in a
study with a split-mouth design and provided informed consent. One hundred sites
were included in the study and divided into fifty test sites and fifty control
sites. These were assessed for plaque index (PI), gingival index (GI), pocket
probing depths, and relative attachment level (RAL) at-pretreatment (baseline), 4,
and 12 weeks posttreatment. The patients received full-mouth SRP. A 0.8% hyaluronan
gel was administered subgingivally in the test sites at baseline and after 1 week.
Significant differences between test and control were evaluated using the t-test,
analysis of variance (test) followed by Bonferroni post hoc test. RESULTS: A
significant reduction in PI and GI was observed in both groups at 12 weeks (P <
0.05). Significant reduction in the pocket probing depths and gain RAL was observed
in both the groups as compared to baseline (P < 0.05). The hyaluronan group
compared to control at 12 weeks showed statistically significant reduction in the
probing pocket depth and gain in RAL (P < 0.05). CONCLUSION: The subgingival
application of 0.8% hyaluronan gel in conjunction with SRP may have a beneficial
effect on periodontal health in patients with chronic periodontitis.
AN - rayyan-563560976
AU - Shah, S. A.
AU - Vijayakar, H. N.
AU - Rodrigues, S. V.
AU - Mehta, C. J.
AU - Mitra, D. K.
AU - Shah, R. A.
DO - 10.4103/0972-124X.201695
IS - 5
LA - eng
N1 - Department of Periodontology, TPCT's Terna Dental College, Navi Mumbai,
Maharashtra, India.; Department of Periodontology, TPCT's Terna Dental College,
Navi Mumbai, Maharashtra, India.; Department of Periodontology, TPCT's Terna Dental
College, Navi Mumbai, Maharashtra, India.; Department of Periodontology, TPCT's
Terna Dental College, Navi Mumbai, Maharashtra, India.; Department of
Periodontology, TPCT's Terna Dental College, Navi Mumbai, Maharashtra, India.;
Department of Periodontology, TPCT's Terna Dental College, Navi Mumbai,
Maharashtra, India.
PY - 2016
SN - 0972-124X (Print)
SP - 549-556
ST - To compare the effect of the local delivery of hyaluronan as an adjunct to
scaling and root planing versus scaling and root planing alone in the treatment of
TI - To compare the effect of the local delivery of hyaluronan as an adjunct to
scaling and root planing versus scaling and root planing alone in the treatment of
VL - 20
Y2 - 9
ID - 14350
ER -
TY - JOUR
AB - The purpose of this investigation was to determine the ability of
tetracycline-containing fibers to inhibit biofilm formation of peri-implantitis-
associated pathogens [i.e., Porphyromonas gingivalis (Pg), Fusobacterium nucleatum
(Fn), Prevotella intermedia (Pi), and Aggregatibacter actinomycetemcomitans (Aa)].
Tetracycline hydrochloride (TCH) was added to a poly(DL-lactide) [PLA],
poly(epsilon-caprolactone) [PCL], and gelatin [GEL] polymer blend solution at
distinct concentrations to obtain the following fibers: PLA:PCL/GEL (TCH-free,
control), PLA:PCL/GEL + 5 % TCH, PLA:PCL/GEL + 10 % TCH, and PLA:PCL/GEL + 25 %
TCH. The inhibitory effect of TCH-containing fibers on biofilm formation was
assessed by colony-forming units (CFU/mL). Qualitative analysis of biofilm
inhibition was done via scanning electron microscopy (SEM). Statistical
significance was reported at p < 0.05. Complete inhibition of biofilm formation on
the fibers was observed in groups containing TCH at 10 and 25 wt%. Fibers
containing TCH at 5 wt% demonstrated complete inhibition of Aa biofilm. Even though
a marked reduction in CFU/mL was observed with an increase in TCH concentration, Pi
proved to be the most resilient microorganism. SEM images revealed the absence of
or a notable decrease in bacterial biofilm on the TCH-containing nanofibers.
Collectively, our data suggest that tetracycline-containing fibers hold great
potential as an antibacterial dental implant coating.
AN - rayyan-563562512
AU - Shahi, R. G.
AU - Munchow, E. A.
AU - Blanchard, S. B.
AU - Gregory, R. L.
AU - Bottino, M. C.
DO - 10.1007/s10266-016-0268-z
IS - 3
PY - 2017
SN - ["1618-1247", "1618-1255"]
SP - 354-363
ST - Novel bioactive tetracycline-containing electrospun polymer fibers as a
potential antibacterial dental implant coating
T2 - ODONTOLOGY
TI - Novel bioactive tetracycline-containing electrospun polymer fibers as a
potential antibacterial dental implant coating
VL - 105
Y2 - 7
ID - 15886
ER -
TY - JOUR
AB - Since the oral mucosa is continuously exposed to abundant microbes, one of
its most important defense features is a highly proliferative, thick, stratified
epithelium. The cellular mechanisms responsible for this are still unknown. The aim
of this study was to determine whether multi-species oral biofilm contribute to the
extensive stratification and primed antimicrobial defense in epithelium. Two in
vitro models were used: 3D reconstructed human gingiva (RHG) and oral bacteria
representative of multi-species commensal biofilm. The organotypic RHG consists of
a reconstructed stratified gingiva epithelium on a gingiva fibroblast populated
hydrogel (lamina propria). Biofilm was cultured from healthy human saliva, and
consists of typical commensal genera Granulicatella and major oral microbiota
genera Veillonella and Streptococcus. Biofilm was applied topically to RHG and
host-microbiome interactions were studied over 7 days. Compared to unexposed RHG,
biofilm exposed RHG showed increased epithelial thickness, more organized
stratification and increased keratinocyte proliferation. Furthermore biofilm
exposure increased production of RHG anti-microbial proteins Elafin, HBD2 and HBD3
but not HBD1, adrenomedullin or cathelicidin LL-37. Inflammatory and antimicrobial
cytokine secretion (IL-6, CXCL8, CXCL1, CCL20) showed an immediate and sustained
increase. In conclusion, exposure of RHG to commensal oral biofilm actively
contributes to RHG epithelial barrier function.
AN - rayyan-563562600
AU - Shang, L.
AU - Deng, D. M.
AU - Janus, M. M.
AU - Krom, B. P.
AU - Roffel, S.
AU - Waaijman, T.
AU - van Loveren, C.
AU - Crielaard, W.
AU - Gibbs, S.
DO - 10.1038/s41598-018-34390-y
PY - 2018
SN - 2045-2322
ST - Multi-species oral biofilm promotes reconstructed human gingiva epithelial
barrier function
TI - Multi-species oral biofilm promotes reconstructed human gingiva epithelial
barrier function
VL - 8
Y2 - 10 y3 - 30
ID - 15974
ER -
TY - JOUR
AB - Dental caries and periodontal diseases are chronic infectious diseases caused
by oral bacteria. Local sustained release delivery systems extend the time in which
the drug is present in the oral cavity, thus enhancing its therapeutic potential
while reducing ifs side effects. Amine-fluorides (AmF) ape known anticaries agents
and have recently been found to have an antibacterial effect against periodontal
pathogens and caries-associated bacteria. The purpose Of this in vitro study was to
assess the antimicrobial activity of a local sustained release device (LSRD)
containing AmF on Streptococcus sobrinus 6715. LSRD was prepared from an
ethylcellulose matrix containing AmF. Release kinetics of AmF from the LSRD was
measured simultaneously with its antimicrobial activity. The organic amine and the
fluoride were released in different kinetics profiles: The fluoride was released
faster than the organic amine. The antimicrobial activity of AmF was measured on
planktonic bacteria in solution and on bacteria as part of experimental dental
plaque. During a 10-day period, the concentration of the released AmF was above its
MIC and no bacterial growth was observed. Bacterial counts in the dental plaque
were reduced by 1 to 2 log units. Hence, the LSRD containing AmF has the potential
to serve as a medicament in prevention and treatment of dental caries and
periodontal diseases. (C) 1998 Elsevier Science Inc.
AN - rayyan-563562460
AU - Shani, S.
AU - Friedman, M.
AU - Steinberg, D.
DO - 10.1016/S0732-8893(97)00208-3
IS - 2
PY - 1998
SN - 0732-8893
SP - 93-97
ST - In vitro assessment of the antimicrobial activity of a local sustained
release device containing amine fluoride for the treatment of oral infectious
diseases
T2 - DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
TI - In vitro assessment of the antimicrobial activity of a local sustained
release device containing amine fluoride for the treatment of oral infectious
diseases
VL - 30
Y2 - 2
ID - 15834
ER -
TY - JOUR
AB - Every living organism comprises of lipids as basic building blocks in
addition to other components. Utilizing these lipids for pharmaceutical and
biomedical applications can overcome biocompatibility and biodegradability issues.
A well known example is liposomes (lipids arranged in lamellar structures), but
other than that there are additional unique mesophasic structures of lipids formed
as a result of lipid polymorphisms, which include cubic-, hexagonal- or sponge-
phase structures. These structures provide the advantages of stability and
production feasibility compared with liposomes. Cubosomes, which exist in a cubic
structure, have improved stability, bioadhesivity and biocompatibility. Hexagonal
phases or hexosomes exhibit hexagonal arrangements and can encapsulate different
drugs with high stability. Lipids also forms tube-like structures known as tubules
and ribbons that are also utilized in different biomedical applications, especially
in tissue engineering. Immune stimulating complexes are nanocage-like structures
formed as a result of interactions of lipid, antigen and Quillaja saponin. These
lipidic mesophasic structures have been utilized for gene, vaccine and drug
delivery. This article addresses lipid self-assembled supramolecular
nanostructures, including cubosomes, hexosomes, tubules, ribbons, cochleates,
lipoplexes and immune stimulating complexes and their biomedical applications. ©
2011 Future Science Ltd.
AN - rayyan-563560609
AU - Shanmugam, T.
AU - Banerjee, R.
DO - 10.4155/tde.11.105
IS - 11
KW - aciclovir
amphotericin B
amphotericin B lipid complex
calcium chloride
carboplatin
cinnarizine
cyclosporine
desmopressin
enkephalin
ephrin receptor A2
furosemide
hydrocarbon
indometacin
insulin
irinotecan
itraconazole
lipid
liposome
naltrexone
nanomaterial
nanoribbon
paclitaxel
progesterone
recombinant blood clotting factor 8
self assembled monolayer
simvastatin
tetracycline
unindexed drug
vaccine
aerosol
biosensor
cell organelle
chemical structure
colorectal cancer
dialysis
drug administration route
drug efficacy
drug formulation
drug potency
drug solubility
drug stability
edema
glioma
heart failure
human
hydrogel
hypertension
lamellar body
lipid composition
lipid vesicle
microtubule
mycosis
nanoencapsulation
nanopharmaceutics
nonhuman
ovary tumor
periodontitis
phase transition
priority journal
review
skin infection
supramolecular chemistry
systemic therapy
tissue engineering
ultracentrifugation
abelcet
zovirax
LA - English
PY - 2011
SN - ["2041-6008", "2041-5990"]
SP - 1485-1516
ST - Nanostructured self assembled lipid materials for drug delivery and tissue
engineering
T2 - Ther. Deliv.
TI - Nanostructured self assembled lipid materials for drug delivery and tissue
engineering
VL - 2
ID - 13983
ER -
TY - JOUR
AB - Curcumin has been used in numerous anti-microbial research because of its low
side effects and extensive traditional applications. Despite having a wide range of
effects, the intrinsic physicochemical characteristics such as low bioavailability,
poor water solubility, photodegradation, chemical instability, short half-life and
fast metabolism of curcumin derivatives limit their pharmaceutical importance. To
overcome these drawbacks and improve the therapeutic ability of curcuminoids, novel
approaches have been attempted recently. Nanoparticulate drug delivery systems can
increase the efficiency of curcumin in several diseases, especially infectious
diseases. These innovative strategies include polymeric nanoparticles, hydrogels,
nanoemulsion, nanocomposite, nanofibers, liposome, nanostructured lipid carriers
(NLCs), polymeric micelles, quantum dots, polymeric blend films and nanomaterial-
based combination of curcumin with other anti-bacterial agents. Integration of
curcumin in these delivery systems has displayed to improve their solubility,
bioavailability, transmembrane permeability, prolong plasma half-life, long-term
stability, target-specific delivery and upgraded the therapeutic effects. In this
review paper, a range of in vitro and in vivo studies have been critically
discussed to explore the therapeutic viability and pharmaceutical significance of
the nano-formulated delivery systems to elevate the anti-bacterial activities of
curcumin and its derivatives.
AN - rayyan-563560109
AU - Sharifi, S.
AU - Fathi, N.
AU - Memar, M. Y.
AU - Hosseiniyan Khatibi, S. M.
AU - Khalilov, R.
AU - Negahdari, R.
AU - Zununi Vahed, S.
DO - 10.1002/ptr.6658
IS - 8
KW - carbon nanotube
chitosan
curcumin
FtsZ protein
graphene oxide
guanosine triphosphatase
hydrogel
liposome
macrogol
nanofiber
polyglactin
polyvinyl alcohol
quantum dot
silk fibroin
vancomycin
antifungal activity
bacterial clearance
biocompatibility
controlled study
cytotoxicity
drug efficacy
drug elimination
drug formulation
drug penetration
drug potency
drug solubility
drug stability
hydrogen bond
hydrophilicity
hydrophobicity
lipophilicity
micelle
nanoemulsion
nonhuman
particle size
periprosthetic joint infection
physical chemistry
prevalence
protein synthesis
review
tensile strength
LA - English
PY - 2020
SN - ["1099-1573", "0951-418X"]
SP - 1926-1946
ST - Anti-microbial activity of curcumin nanoformulations: New trends and future
perspectives
TI - Anti-microbial activity of curcumin nanoformulations: New trends and future
perspectives
VL - 34
ID - 13483
ER -
TY - JOUR
AB - Aloe Vera is attracting the attention of scientists, researchers, and people
around the world once again. Because of the multiple uses of Aloe Vera, and the
easy growth and maintenance of the plant, many researchers of public and private
sector have gained interest in this plant. Many novel and effective uses of Aloe
Vera have come in light due to the researches on Aloe Vera in the field of biology,
biochemistry and clinical studies. The beneficial effectiveness of Aloe in wound
healing and being an anti-inflammatory is due to some constituents of Aloe that are
involved in the healing process. According to the recent studies, the presence of
mannose-6-phosphate, the important sugar in the Aloe gel, is mainly responsible for
the wound healing properties of Aloe Vera, and thus considered its possibility of
being an active growth substance. Scientist found an innovative and interesting
usage of Aloe Vera gel as an edible coating on fruits and vegetables that act as
the healthy preservative coating and thus will preserve the quality and safety of
fruits during cold storage. This study was done on papaya that resulted in its
subsequent increase in shelf life. The gel also offers protection from some of the
dangerous pathogens by inhibiting their growth, and it also provides numerous
health benefits. It is because of this reasons, Aloe products are so popular in the
market and are widely used in skin care, cosmetics, medical, health care and food
industry.
AN - rayyan-563560470
AU - Sharma, A.
AU - Gautam, S.
IS - 3
amino acid
anthraquinone derivative
antiinfective agent
chitosan
curcumin
enzyme
herbaceous agent
hormone
lignin
mineral
salicylic acid
saponin derivative
sterol derivative
sugar
vitamin
antifungal activity
article
candidiasis
contact dermatitis
dental caries
diabetes mellitus
drug efficacy
drug mechanism
drug response
drug safety
gastrointestinal tract function
gel
human
immunomodulation
infection control
coating (procedure)
medicinal plant
mouth infection
nonhuman
periodontal disease
phytochemistry
sunburn
textile industry
ulcer
wound healing
wound infection
LA - English
PY - 2013
SN - 0975-6299
SP - P694-P705
ST - An overview on medicinal properties of aloe vera: Antibacterial & antifungal
aspects
T2 - Intl. J. Pharma Bio Sci.
TI - An overview on medicinal properties of aloe vera: Antibacterial & antifungal
aspects
VL - 4
ID - 13844
ER -
TY - JOUR
AN - rayyan-563561683
AU - Sharma, H. M.
AU - Deepika, P. C.
AU - Chandan, S.
AU - Shashikumar, P.
DO - 10.4103/jioh.jioh_249_20
IS - 1
PY - 2021
SP - 17-23
ST - Efficacy of 3% Psidium guajava local drug delivery in the treatment of
T2 - Journal of International Oral Health
TI - Efficacy of 3% Psidium guajava local drug delivery in the treatment of
85100516263&doi=10.4103%2fjioh.jioh_249_20&partnerID=40&md5=63851d6c38f16180a1bdd7b
86328cc4e
VL - 13
ID - 15057
ER -
TY - JOUR
AB - Background: Achievement and maintenance of osseointegration is the prime
requisite for the long term success of dental implant in the oral cavity. Various
measures have been described in literature to coat the dental implant with a bio-
stimulant for achieving adequate and rapid osseointegration. The purpose of present
case series was to clinically and radiographically assess the osseointegration
around dental implants coated with 1% Metformin gel, in terms of bone mineral
density and radiofrequency analysis. Methods: A total of 22 subjects with missing
tooth in the mandibular posterior region were selected and divided into two groups
for the study; test group (implants coated with 1% metformin gel prior to their
placement) and control group (non-coated dental implants). Along with bone mineral
density (BMD) in hounsfield units (HU) and radiofrequency analysis (RFA); clinical
parameters including oral hygiene index-simplified (OHI-S), gingival bleeding index
(GBI), modified plaque index (mPI), modified gingival index(mGI), modified sulcular
bleeding index(mSBI), width of keratinized mucosa (WKM), probing depth(PD) were
recorded at baseline 4 months and all the implants were revaluated at 24 months.
Results: There was a statistically significant increase in the mean bone mineral
densities at the test area at 4 months (1330.1±21.6HU) when compared to control
group. Also, the mean ISQ value for both the groups increased significantly during
the course of 4 months. Conclusions: The coating of Metformin on implants has a
positive bio-stimulatory effect on osseointegration achieved by them. In the
present study this effect was found to be significant for shorter interval (4
months).
AN - rayyan-563560029
AU - Sharma, H.
AU - Sharma, A.
AU - Gupta, S.
AU - Mowar, A.
AU - Kusum, C.
DO - 10.31838/ijpr/2021.13.01.055
IS - 1
KW - autoclave
dental prosthesis and implant
screw retained crown
tooth implant
amoxicillin
ibuprofen
metformin
poloxamer
adult
article
bone density
depth perception
digital imaging and communications in medicine
female
human
human experiment
implant stability quotient
intelligence quotient
male
mandible
modified gingival index
modified sulcular bleeding index
mouth cavity
mouth hygiene
mouth mucosa
normal human
oral hygiene index
oral hygiene index simplified scale
osseointegration
osteotomy
periodontal disease
plaque index
probing depth
radiofrequency
radiofrequency analysis
tooth radiography
LA - English
PY - 2021
SN - 0975-2366
SP - 393-399
ST - Evaluation of the effect of 1% metformin gel coating on the osseointegration
achieved around dental implants using bone mineral density and radiofrequency
analysis-a clinical and three-dimensional radiographic study
TI - Evaluation of the effect of 1% metformin gel coating on the osseointegration
achieved around dental implants using bone mineral density and radiofrequency
analysis-a clinical and three-dimensional radiographic study
VL - 13
ID - 13403
ER -
TY - JOUR
AB - BACKGROUND Periodontitis is an immune-inflammatory disease of the tissues
surrounding the teeth. Various treatment modalities like mechanical debridement and
use of antimicrobials have been followed in such conditions. Introduction of local
drug delivery system in the periodontal pocket is a promising therapeutic modality
for achieving better clinical outcomes when used as an adjunct to conventional non-
surgical periodontal therapy. It was in the year 1979, Dr. Max Goodson et al first
proposed the concept of controlled delivery in the treatment of periodontitis. So,
the present study was designed to evaluate the clinical effects of topical
application of Xanthan gel (chlorhexidine coadjuvant) in the treatment of
aggressive periodontitis. The present study was designed to evaluate the clinical
effects of topical application of Xanthan gel (chlorhexidine coadjuvant) in the
treatment of aggressive periodontitis. MATERIALS AND METHODS This study was carried
out on 5 patients (Aged 25-40) with aggressive periodontitis. They received root
planning and curettage alone on one side and Xanthan gel (Chlorhexidine coadjuvant)
on the other side. Each individual was subjected to the following measurements: (1)
Evaluation of the clinical parameters pre- and post-treatment to detect the outcome
of the treatment modality or at 1, 3 and 6 months were obtained for microbiological
evaluation. RESULTS 1. Xanthan gel delivered locally into periodontal disease sites
reduced all subgingival bacteria, and 2. Both treatments and modalities led to
statistically significant reduction in microbiological counts as well as clinical
parameters applied. CONCLUSION The results showed that syringe of Xanthan gel with
root planning and curettage and levelling of the root surface resulted in a greater
improvement in periodontal clinical indices than root planning alone.
AN - rayyan-563562047
AU - Sharma, K.
AU - Krishna, M. K.
AU - Jain, R.
AU - Kumar, M.
DO - 10.14260/jemds/2018/683
IS - 26
PY - 2018
SN - ["2278-4748", "2278-4802"]
SP - 3045-3048
ST - ROLE OF CHLOSITE GEL DELIVERY IN THE MANAGEMENT OF AGGRESSIVE PERIODONTITIS
ATTENDING THE OUTPATIENT DEPARTMENT OF DENTISTRY, VARUN ARJUN MEDICAL HOSPITAL,
BANTHRA, SHAHJAHANPUR (U. P.)- A PILOT STUDY
T2 - JOURNAL OF EVOLUTION OF MEDICAL AND DENTAL SCIENCES-JEMDS
TI - ROLE OF CHLOSITE GEL DELIVERY IN THE MANAGEMENT OF AGGRESSIVE PERIODONTITIS
ATTENDING THE OUTPATIENT DEPARTMENT OF DENTISTRY, VARUN ARJUN MEDICAL HOSPITAL,
BANTHRA, SHAHJAHANPUR (U. P.)- A PILOT STUDY
VL - 7
Y2 - 6 y3 - 25
ID - 15421
ER -
TY - JOUR
AB - Dental ailments are frequently encountered health problems in human being
throughout the world. There are various dental diseases such as pyorrhoea, dental
caries and oral candidiasis which generally occur due to improper cleaning of
teeth. Natural remedies are more acceptable in the belief that they are safer with
fewer side effects than synthetic ones. Herbal drugs cannot be directly used as in
its crude form, rather needs to be formulated in a specific dosage form,e. g.,
tooth powder, mouthwash, gel etc. The present research work aims to formulate and
evaluate the herbal dental gel containing clove oil and eucalyptus oil
havingbactericidal activity in mouth, reducing plaque, and preventing gum diseases.
The herbal dental gelwas formulated using carbopol 934 and gumtragacanthasgelling
agents, NaOH asneutralizing agent, menthol and camphoras analgesic and counter
irritant. The formulated dental gel was evaluated for physical and anti-microbial
activity. The appearance was found to be transparent, homogeneous withgood
spreadability and no grittiness. In antimicrobial test, number of microbial
colonies observed in Plate-A (Blank), Plate- B (Test) and Plate-C (Reference) were
9, 5 and 4 respectively, which confirms that the antimicrobial activity of
developed formulation is comparable to marketed product. .
AN - rayyan-563560232
AU - Sharma, M.
AU - Soni, R.
IS - 11
KW - analgesic agent
antiinfective agent
carbopol 934
clove oil
eucalyptus oil
herbaceous agent
irritant agent
menthol
mouthwash
sodium hydroxide
conference abstract
controlled study
drug formulation
gingiva disease
human
mouth
powder
prevention
LA - English
PY - 2018
SN - 2455-3891
SP - 180
ST - Development of essential oils based herbal dental gel for treatment of
TI - Development of essential oils based herbal dental gel for treatment of
VL - 11
ID - 13606
ER -
TY - JOUR
AB - BACKGROUND: Pro-inflammatory cytokine gene polymorphisms are potential
candidates for susceptibility for both type 2 diabetes mellitus (DM) and chronic
periodontitis (CHP). This study explored the association of interleukin-1 beta (IL-
1 β) +3954, interleukin-6 (IL-6) -597/-174 and tumor necrosis factor-alpha (TNF-α)
-308 single nucleotide polymorphisms in CHP with and without type 2 DM in Malayalam
speaking subjects of Dravidian ethnicity. MATERIALS AND METHODS: This case control
study consisted of 51 chronic periodontitis with type 2 diabetes mellitus (CHPDM)
and 51 CHP patients as cases and 51 healthy subjects as controls. Polymorphisms
were identified by polymerase chain reaction amplification followed by restriction
enzyme digestion and gel electrophoresis. RESULTS: IL-1 β (+3954) TT genotype and T
allele were significantly associated with CHPDM group when compared with CHP (P =
0.001), whereas CC genotype and allele C was higher in CHP subjects (P = 0.001).
For IL-6 (-597) frequency of genotype GA/AA (P = 0.04) and allele A (P = 0.01) was
lower in CHPDM group, and for TNF-α -308 the frequency of genotype GA (P = 0.01)
and allele A (P = 0.01) was higher in CHP subjects when compared with controls.
CONCLUSIONS: In Malayalam speaking Dravidian population, IL-6 (-597) genotype GA/AA
and allele A appears to be protective for CHP with type 2 DM. Allele C of IL-1 β
+3954 and allele A of TNF-α -308 appears to be risk factors for CHP individuals.
AN - rayyan-563560425
AU - Sharma, N.
AU - Joseph, R.
AU - Arun, R.
AU - Chandni, R.
AU - Srinivas, K. L.
AU - Banerjee, M.
DO - 10.4103/0970-9290.138343
IS - 3
KW - interleukin 1beta
interleukin 6
case control study
chronic disease
complication
genetics
human
periodontitis
LA - English
PY - 2014
SN - 1998-3603
SP - 375-380
ST - Cytokine gene polymorphism (interleukin-1β +3954, Interleukin-6 [-597/-174]
and tumor necrosis factor-α -308) in chronic periodontitis with and without type 2
diabetes mellitus
TI - Cytokine gene polymorphism (interleukin-1β +3954, Interleukin-6 [-597/-174]
and tumor necrosis factor-α -308) in chronic periodontitis with and without type 2
diabetes mellitus
VL - 25
ID - 13799
ER -
TY - JOUR
AB - There is evidence that the lipid A-associated proteins (LAPs) of enteric
bacteria can induce the synthesis of interleukin 1 (IL-1) and therefore may be
important virulence factors. Porphyromonas gingivalis is now recognized as a major
pathogen in the chronic inflammatory periodontal diseases and it has previously
been reported that a crude LAP fraction from this organism could induce IL-1 and
interleukin 6 (IL-6) synthesis. In the present study the chemical and biological
properties of the LAPs of this bacterium have been further characterized. Analysis
by SDS-PAGE has shown that the LAPs comprise nine proteins of molecular masses 81,
68, 48, 47, 28, 25, 20, 17 and 16 kDa. These LAPs, at concentrations as low as 100
ng ml-1, were shown to stimulate human gingival fibroblasts, human peripheral blood
mononuclear cells and whole human blood to produce the pro-inflammatory cytokine
IL-6. The cytokine-inducing activity of the LAPs was reduced after heat-
inactivation and trypsinization, suggesting that the activity was not due to
contaminating LPS. To establish which proteins in this mixture were the active
cytokine inducers, the LAPs were separated by electrophoresis on polyacrylamide
gels. The majority of the activity was associated with the 17 kDa LAP. N-terminal
sequence analysis demonstrated that this protein was homologous to an internal
region of a conserved adhesin domain contained within a family of P. gingivalis
extracellular proteins including the RI protease, Lys-gingipain, porphypain and
haemagglutinin A. In addition to a role in adherence, the adhesin domain(s) of
these proteins may also have cytokine-inducing properties. Furthermore, it has also
been shown that the previously observed degradation of cytokines by P. gingivalis
may be attributable to the catalytic domain of the RI protease. Thus, different
domains within the same molecule appear to have opposing actions on pro-
inflammatory cytokine levels and the balance between these two activities may
influence the cytokine status of the periodontium in patients with the common
chronic inflammatory conditions known as the periodontal diseases.
AN - rayyan-563561019
AU - Sharp, L.
AU - Poole, S.
AU - Reddi, K.
AU - Fletcher, J.
AU - Nair, S.
AU - Wilson, M.
AU - Curtis, M.
AU - Henderson, B.
AU - Tabona, P.
DO - 10.1099/00221287-144-11-3019
IS - 11
interleukin 6
proteinase
amino acid sequence
article
fibroblast
heat treatment
human
human cell
molecular weight
mononuclear cell
multigene family
nonhuman
priority journal
protein analysis
LA - English
PY - 1998
SN - 1350-0872
SP - 3019-3026
ST - A lipid A-associated protein of Porphyromonas gingivalis, derived from the
haemagglutinating domain of the RI protease gene family, is a potent stimulator of
interleukin 6 synthesis
T2 - Microbiology
TI - A lipid A-associated protein of Porphyromonas gingivalis, derived from the
haemagglutinating domain of the RI protease gene family, is a potent stimulator of
interleukin 6 synthesis
VL - 144
ID - 14393
ER -
TY - JOUR
AB - Objectives: Porphyromonas gingivalis, an asaccharolytic, Gram-negative
anaerobic bacterium is recognized as an important pathogen of periodontitis. The
bacterium secretes large amounts of cysteine proteases, gingipains, which are
essential virulence factors. The mechanism of gingipain secretion is a subject of
intense investigation and up to date several proteins have been identified as
components of the outer membrane (OM) translocation machinery. Apart from
functioning in thegingipain secretion some proteins of the secretion apparatus may
work as independent virulence factors. To verify this assumption we have compared
ability of mutants deficient in individual proteins involved in secretion to form
biofilm and adhere to professional phagocytes in the context of the outer membrane
proteome. Materials and Methods: Wild-type P. gingivalis W83 and isogenic mutants
deficient of sov, porT, PG0022, PG0266, PG0543, and PG1403 genes essential for
gingipains secretion were grown to an early stationary phase. Bacterial biofilm
formation and adherence to the RAW 264.7 macrophages were estimated by crystal
violet staining and FACS analysis, respectively. Gingipain activity was assayed in
full culture and bacterial cell homogenates. The outer membrane fraction was
separated, resolved by SDS-PAGE and subjected to peptide fingerprinting to identify
proteins in the OM. Results: In contrast to the parental strain, secretion system
mutants show no gingipain activity in full cultures and in cell homogenates. All
mutants adhered to the plastic surface far more efficiently than the wild type
strain W83. Most interestingly, however, only the sov mutant vividly adhered to
macrophages. To explain the mechanism of adherence, the proteome of the OM derived
from wild-type, delta-sov and delta-PG0266 strains was compared. The proteome of
both strains was found identical but different than that of the parental strain.
Conclusion: The lack of gingipain secretion strongly enhances the P. gingivalis
binding to plastic surface. Conversely, gingipains are apparently dispensable for
protecting the bacterium from adherence to macrophages. From the comparative
analysis of mutant strains phenotype and the OM proteome, the Sov protein was
identified as the virulence factor which prevents the direct contact between P.
gingivalis and phagocytes. This may protect the bacterium from phagocytosis and
destruction. In this way Sov may significantly contribute to the P. gingivalis
pathogenicity.
AN - rayyan-563560598
AU - Shashkova, S.
AU - Koziel, J.
AU - Maresz, K.
AU - Thogersen, I.
AU - Enghild, J.
AU - Guo, Y.
AU - Potempa, J.
DO - 10.1111/j.1469-0691.2011.03558.x
KW - protein
virulence factor
proteome
plastic
peptide
cysteine proteinase
crystal violet
secretion (process)
mutant
macrophage
outer membrane
wild type
phagocyte
cell free system
biofilm
type strain
phenotype
phagocytosis
pathogenicity
anaerobic bacterium
pathogenesis
periodontitis
machine
essential gene
staining
bacterial cell
LA - English
PY - 2011
SN - 1198-743X
SP - S515-S516
ST - The Sov protein of the Porphyromonas gingivalis secretion system functions as
an independent virulence factor
T2 - Clin. Microbiol. Infect.
TI - The Sov protein of the Porphyromonas gingivalis secretion system functions as
an independent virulence factor
VL - 17
ID - 13972
ER -
TY - JOUR
AB - Objective - to study the effectiveness of topical application of standardized
fermented papaya gel (SFPG) in the complex therapy of moderate chronic
periodontitis developed as an orthodontic treatment complication. Material and
Methods - Our study involved 50 patients with periodontitis of a moderate severity
developed against the background of a treatment with a fixed orthodontic appliance.
Periodontitis has developed as a long-term consequence of the fixed orthodontic
appliance. Orthodontic treatment of patients was carried out with metal ligature
braces. The patients were divided into two groups: Group 1 with conventional
periodontitis treatment supplemented by SFPG applications on the gums for 15
minutes daily during 14 days; Group 2 with conventional treatment alone. The
concentration of proinflammatory and anti-inflammatory cytokines in periodontal
pockets was determined using solid-phase type of enzyme immunoassay (Vector-Best
test system, Russia). The nitrite/nitrate content in the periodontal pocket fluid
was determined spectrophotometrically using the Griess reagent kit, following the
manufacturer's instructions (Sigma-Aldrich, USA). Results - Patients receiving SFGP
exhibited a reduction in inflammation, manifested in decreased gum bleeding,
swelling, hyperemia, and exudate from periodontal pockets. We observed the
restoration of the balance of proinflammatory cytokines (IL-1 beta, IL-6) and
antiinflammatory interleukin (IL-10), and reduction in the nitrite/nitrate content.
Conclusion - Clinical effectiveness of the therapy with natural fermented herbal
preparations may be associated with its antioxidant and antimicrobial properties.
AN - rayyan-563562289
AU - Sheregov, A. K.
AU - Mustafaev, M. S.
AU - Korkina, L. G.
AU - Batyrbekova, F. R.
AU - Agnokova, T. K.
DO - 10.15275/rusomj.2021.0425
IS - 4
PY - 2021
SN - 2304-3415
ST - Effectiveness of using fermented herbal preparation in complex therapy of
periodontitis developed as an orthodontic treatment complication
T2 - RUSSIAN OPEN MEDICAL JOURNAL
TI - Effectiveness of using fermented herbal preparation in complex therapy of
VL - 10
Y2 - 12
ID - 15663
ER -
TY - JOUR
AB - Objective — to study the effectiveness of topical application of standardized
fermented papaya gel (SFPG) in the complex therapy of moderate chronic
periodontitis developed as an orthodontic treatment complication. Material and
Methods — Our study involved 50 patients with periodontitis of a moderate severity
developed against the background of a treatment with a fixed orthodontic appliance.
Periodontitis has developed as a long-term consequence of the fixed orthodontic
appliance. Orthodontic treatment of patients was carried out with metal ligature
braces. The patients were divided into two groups: Group 1 with conventional
periodontitis treatment supplemented by SFPG applications on the gums for 15
minutes daily during 14 days; Group 2 with conventional treatment alone. The
concentration of proinflammatory and anti-inflammatory cytokines in periodontal
pockets was determined using solid-phase type of enzyme immunoassay (Vector-Best
test system, Russia). The nitrite/nitrate content in the periodontal pocket fluid
was determined spectrophotometrically using the Griess reagent kit, following the
manufacturer’s instructions (Sigma-Aldrich, USA). Results — Patients receiving SFGP
exhibited a reduction in inflammation, manifested in decreased gum bleeding,
swelling, hyperemia, and exudate from periodontal pockets. We observed the
restoration of the balance of proinflammatory cytokines (IL-1β, IL-6) and anti-
inflammatory interleukin (IL-10), and reduction in the nitrite/nitrate content.
Conclusion — Clinical effectiveness of the therapy with natural fermented herbal
preparations may be associated with its antioxidant and antimicrobial properties.
AN - rayyan-563559939
AU - Sheregov, A. Kh
AU - Mustafaev, M. Sh
AU - Korkina, L. G.
AU - Batyrbekova, F. R.
AU - Agnokova, T. Kh
DO - 10.15275/rusomj.2021.0425
IS - 4
KW - brace
CT scanner
dental floss
fixed orthodontic appliance
orthodontic device
antioxidant
cytokine
gamma interferon
gel
herbaceous agent
interleukin 10
interleukin 1beta
interleukin 4
interleukin 6
standardized fermented papaya gel
unclassified drug
adult
article
bleeding
controlled study
DNA extraction
enzyme immunoassay
female
fermentation
fermented product
gingiva bleeding
gingivitis
herbal medicine
human
hyperemia
inflammation
malaise
male
mouth hygiene
orthodontic procedure
orthodontics
papaya
periodontal disease
periodontal index
periodontal pocket
periodontitis
plaque index
swelling
tooth papilla
tooth plaque
young adult
LA - English
PY - 2021
SN - 2304-3415
ST - Effectiveness of using fermented herbal preparation in complex therapy of
T2 - Russ. Open Med. J.
TI - Effectiveness of using fermented herbal preparation in complex therapy of
VL - 10
ID - 13313
ER -
TY - JOUR
AB - The objectives of present research were to develop and characterize
thermosensitive and mucoadhesive polymer-based sustained release moxifloxacin in
situ gels for the treatment of periodontal diseases. Poloxamer- and chitosan-based
in situ gels are in liquid form at room temperature and transform into gel once
administered into periodontal pocket due to raise in temperature to 37 °C. Besides
solution-to-gel characteristic of polymers, their mucoadhesive nature aids the gel
to adhere to mucosa in periodontal pocket for prolonged time and releases the drug
in sustained manner. These formulations were prepared using cold method and
evaluated for pH, solution-gel temperature, syringeability and viscosity. In vitro
drug release studies were conducted using dialysis membrane at 37 °C and 50 rpm.
Antimicrobial studies carried out against Aggregatibacter actinomycetemcomitans
(A.A.) and Streptococcus mutans (S. Mutans) using agar cup-plate method. The
prepared formulations were clear and pH was at 7.01–7.40. The viscosity of
formulations was found to be satisfactory. Among the all, formulations comprising
of 21% poloxamer 407 and 2% poloxamer 188 (P5) and in combination with 0.5% HPMC
(P6) as well as 2% chitosan and 70% β-glycerophosphate (C6) demonstrated an ideal
gelation temperature (33–37 °C) and sustained the drug release for 8 h.
Formulations P6 and C6 showed promising antimicrobial efficacy with zone of
inhibition of 27 mm for A.A. and 55 mm for S. Mutans. The developed sustained
release in situ gel formulations could enhance patient’s compliance by reducing the
dosing frequency and also act as an alternative treatment to curb periodontitis.
AN - rayyan-563560194
AU - Sheshala, R.
AU - Quah, S. Y.
AU - Tan, G. C.
AU - Meka, V. S.
AU - Jnanendrappa, N.
AU - Sahu, P. S.
DO - 10.1007/s13346-018-0488-6
IS - 2
biopolymer
chitosan
moxifloxacin
poloxamer
article
controlled study
gelation
heat sensitivity
hydrogel
in vitro study
liquid
mucoadhesion
nonhuman
periodontal pocket
periodontitis
priority journal
viscosity
zone of inhibition
LA - English
PY - 2019
SN - ["2190-3948", "2190-393X"]
SP - 434-443
ST - Investigation on solution-to-gel characteristic of thermosensitive and
mucoadhesive biopolymers for the development of moxifloxacin-loaded sustained
release periodontal in situ gels
T2 - Drug Deliv. Transl. Res.
TI - Investigation on solution-to-gel characteristic of thermosensitive and
mucoadhesive biopolymers for the development of moxifloxacin-loaded sustained
release periodontal in situ gels
VL - 9
ID - 13568
ER -
TY - JOUR
AB - WHILE THE EFFICACY OF ORAL IRRIGATIONS with antimicrobial agents on the
clinical and microbial parameters of gingivitis is well established, the study of
the efficacy of intrapocket irrigants on periodontitis has yielded conflicting and
inconclusive results regarding both clinical and microbiological parameters. The
overall goal of this review paper is to summarize the available information on the
efficacy of intrapocket irrigation in the treatment of patients with periodontitis.
The following topics are addressed: 1) the penetrability of the irrigant; 2) pocket
irrigation without scaling and root planing; 3) professional pocket irrigation
following scaling and root planing; 4) irrigations between recalls; and 5) safety
of intrapocket irrigation. Single irrigation of periodontal pockets for short
periods of time before or after scaling and root planing has limited effects on
periodontal healing. However, continuous irrigation of the periodontal lesion with
agents such as povidone iodine during thorough scaling and root planing, such as
that carried out under local anesthesia, has promise as an antimicrobial adjunct in
periodontal therapy.
AN - rayyan-563562232
AU - Shiloah, J.
AU - Hovious, L. A.
DO - 10.1902/jop.1993.64.9.835
IS - 9
PY - 1993
SN - 0022-3492
SP - 835-843
ST - THE ROLE OF SUBGINGIVAL IRRIGATIONS IN THE TREATMENT OF PERIODONTITIS
TI - THE ROLE OF SUBGINGIVAL IRRIGATIONS IN THE TREATMENT OF PERIODONTITIS
VL - 64
Y2 - 9
ID - 15606
ER -
TY - JOUR
AB - Objectives: In-vitro data have shown that cross-linked hyal uronic acid (HA)
enhances the proliferative and migratory properties of cells involved in
periodontal wound healing/re generation, stabilizes the blood clot, reduces the
inflammatory response, and facilitates angiogenesis. The aim of this study was to
histologically evaluate the effects of cross-linked HA alone or combined with a
collagen matrix (CM) on the peri odontal wound healing/regeneration in intrabony
defects. Method and materials: Two-wall intrabony defects (5 mm wide, 5 mm deep)
were surgically created at the distal and mesial aspects of mandibular premolars in
six beagle dogs. The 24 defects were randomly treated as follows: open flap de
bridement (OFD) + HA, OFD + CM, OFD + HA + CM (HA/CM), and OFD alone (control). At
2 months, the animals were eutha nized for histologic evaluation. Results:The HA
(2.43 ± 1.25 mm) and HA/CM (2.60 ± 0.99 mm) groups yielded statistically sig
nificantly (P <.05) greater formation of new attachment (ie, lin ear length of new
cementum adjacent to newly formed bone, with inserting collagen fibers) compared
with the OFD (0.55 ± 0.99 mm) group. Among the four treatment groups, the HA/CM
group demonstrated the highest amount of regenerated tis sues, although no
statistically significant differences in any of the histometric parameters were
observed between the HA and HA/CM groups. Conclusion: Within their limits, it can
be concluded that cross-linked HA alone or combined with CM promotes periodontal
wound healing/regeneration in two-wall intrabony defects in dogs.
AN - rayyan-563560008
AU - Shirakata, Y.
AU - Imafuji, T.
AU - Nakamura, T.
AU - Kawakami, Y.
AU - Shinohara, Y.
AU - Noguchi, K.
AU - Pilloni, A.
AU - Sculean, A.
DO - 10.3290/j.qi.b937003
IS - 4
KW - buprenorphine
chlorphenesin
collagen
dihydrostreptomycin
epinephrine
hyaluronic acid
ketoprofen
leptan
lidocaine
medetomidine
mycillin sol meiji
penicillin G
pentobarbital
analgesia
animal tissue
article
bone length
cementogenesis
clinical observation
collagen fiber
comparative study
connective tissue
controlled study
cross linking
descriptive research
histometry
histopathology
male
morphometry
nonhuman
ossification
osteoblast
osteolysis
periodontics
premolar tooth
reconstructive surgery
tooth cementum
trabecular bone
wound healing
capisten
domitor
somnopentyl
xylocaine
LA - English
PY - 2021
SN - ["1936-7163", "0033-6572"]
SP - 308-316
ST - Periodontal wound healing/regeneration of two-wall intrabony defects
following reconstructive surgery with cross-linked hyaluronic acid-gel with or
without a collagen matrix: A preclinical study in dogs
TI - Periodontal wound healing/regeneration of two-wall intrabony defects
following reconstructive surgery with cross-linked hyaluronic acid-gel with or
without a collagen matrix: A preclinical study in dogs
VL - 52
ID - 13382
ER -
TY - JOUR
AB - Aim: To clinically and histologically evaluate in dogs the healing of
gingival recessions treated with coronally advanced flap (CAF) with or without
cross-linked hyaluronic acid (HA). Materials and methods: Gingival recession
defects were surgically created on the vestibular side of both maxillary canines in
8 dogs. After 8 weeks of plaque accumulation, the 16 chronic defects were randomly
treated with either CAF alone or CAF and HA-gel (CAF/HA). Clinical and histological
outcomes were evaluated at 10 weeks post-surgically. Results: Compared to baseline,
the clinical measurements at 10 weeks revealed a statistically significant decrease
in gingival recession for both CAF (p < 0.01) and CAF/HA (p < 0.001) groups.
Statistically significant differences were found in clinical attachment level (p <
0.05) and width of gingival recession (p < 0.01) favouring the CAF/HA group. Bone
formation was statistically significantly greater in the CAF/HA group than in the
CAF group (1.84 ± 1.16 mm vs., 0.72 ± 0.62 mm, respectively, p < 0.05). Formation
of cementum and connective tissue attachment were statistically significantly
higher in the CAF/HA group compared with the CAF group (i.e. 4.31 ± 1.78 mm versus
2.40 ± 1.35 mm and 1.69 ± 0.98 mm versus 0.74 ± 0.68 mm, respectively (p < 0.05)).
Conclusions: The present data have for the first time provided histologic evidence
for periodontal regeneration of gingival recession defects following treatment with
CAF and HA. Clinical relevance: The use of HA in conjunction with CAF may represent
a novel modality for treating gingival recession defects.
AN - rayyan-563560002
AU - Shirakata, Y.
AU - Nakamura, T.
AU - Kawakami, Y.
AU - Imafuji, T.
AU - Shinohara, Y.
AU - Noguchi, K.
AU - Sculean, A.
DO - 10.1111/jcpe.13433
IS - 4
KW - PCP-UNC 15 periodontal probe
buprenorphine
epinephrine
hyaluronic acid
ketoprofen
lidocaine
medetomidine
pentobarbital
animal experiment
animal tissue
article
connective tissue
controlled study
coronally advanced flap
dog
general anesthesia
gingiva disease
histology
male
nonhuman
ossification
surgical flaps
capisten
domitor
hibitane
xylocaine
LA - English
PY - 2021
SN - ["1600-051X", "0303-6979"]
SP - 570-580
ST - Healing of buccal gingival recessions following treatment with coronally
advanced flap alone or combined with a cross-linked hyaluronic acid gel. An
experimental study in dogs
TI - Healing of buccal gingival recessions following treatment with coronally
advanced flap alone or combined with a cross-linked hyaluronic acid gel. An
experimental study in dogs
VL - 48
ID - 13376
ER -
TY - JOUR
AB - Anastasia Black (Russian sweet pepper) of Capsicum annuum L. var. angulosum
Mill. (Solanaceae) was successively extracted with hexane, acetone, methanol and
70% methanol, and the extracts were further separated into a total of twenty-three
fractions by silica gel or octadecylsilane (ODS; C18) column chromatography. These
extracts and fractions were investigated for their cytotoxicity, anti-human
immunodeficiency virus (HIV), anti-Helicobacter pylori (H. pylori), urease
inhibition and multidrug resistance (MDR) reversal activity. Some fractions of
hexane and acetone extracts showed higher cytotoxic activity against three human
oral tumor cell lines (squamous cell carcinoma HSC-2, HSC-3, submandibular gland
carcinoma HSG) than against three normal human oral cells (gingival fibroblast HGF,
pulp cell HPC, periodontal ligament fibroblast HPLF), suggesting a tumor-specific
cytotoxic activity. No fractions displayed anti-HIV activity, but some hydrophobic
fractions showed higher anti-H. pylori activity, urease inhibition activity and MDR
reversal activity. The higher MDR activity of these fractions against MDR gene-
transfected L5178 mouse lymphoma T cells may possibly be due to their higher
content of carotene or polyphenol. These data suggest that Anastasia Black should
be further investigated as a potent supplement for cancer chemotherapy.
AN - rayyan-563560845
AU - Shirataki, Y.
AU - Kawase, M.
AU - Sakagami, H.
AU - Nakashima, H.
AU - Tani, S.
AU - Tanaka, T.
AU - Sohara, Y.
AU - Schelz, Z.
AU - Molnar, J.
AU - Motohashi, N.
IS - 3
KW - acetone
Anastasia black extract
carotene
hexane
methanol
plant extract
polyphenol
silica gel
unclassified drug
urease
Anastasia black
animal cell
antiviral activity
article
cancer chemotherapy
controlled study
cytotoxicity
drug activity
drug isolation
enzyme inhibition
fibroblast
Helicobacter pylori
Human immunodeficiency virus
lymphoma
mouse
nonhuman
priority journal
salivary gland tumor
separation technique
sweet pepper
LA - English
PY - 2005
SN - 0250-7005
SP - 1991-1999
ST - Bioactivities of Anastasia Black (Russian sweet pepper)
TI - Bioactivities of Anastasia Black (Russian sweet pepper)
VL - 25
ID - 14219
ER -
TY - JOUR
AN - rayyan-563561669
AU - Shirzaei Sani, E.
AU - Portillo Lara, R.
AU - Aldawood, Z.
AU - Bassir, S. H.
AU - Nguyen, D.
AU - Kantarci, A.
AU - Intini, G.
AU - Annabi, N.
DO - 10.1016/j.matt.2019.07.019
IS - 4
PY - 2019
SP - 926-944
ST - An Antimicrobial Dental Light Curable Bioadhesive Hydrogel for Treatment of
Peri-Implant Diseases
T2 - Matter
TI - An Antimicrobial Dental Light Curable Bioadhesive Hydrogel for Treatment of
Peri-Implant Diseases
85076793437&doi=10.1016%2fj.matt.2019.07.019&partnerID=40&md5=5f2260e8225c7a39536de
58f8ebb7ecf
VL - 1
ID - 15043
ER -
TY - JOUR
AB - Objectives: Implant surgery is widely present in the practice of dentists.
The absence of recommendations regarding peri- and, in particular, post-operative
antiseptic management in implantology has led to variations in practice. The
purpose of this study is to describe the actual perioperative usage of orodental
antiseptics and more specifically that of pharma gel. Methods: An observational,
prospective, longitudinal study was conducted in implant surgery in Bulgaria.
Patients having benefited from the placement of one or several implants were
included in the study. Data collected at inclusion consisted in periodontal disease
history and context, description of the surgery, prescription of treatments. During
the follow-up visit, operative wound was assessed as well as treatments, plaque and
gingival index and satisfaction of the dentist. Results: A total of 275 patients
were included. The sex ratio was 1:1 and the mean age was 47 ±13.2 years. Two-stage
surgery was performed on 61.1% patients, and 56.4% had a single implant. Before
surgery, antibiotics and antiseptics mouthwash were the most prescribed. During the
preparation of the operative site, 83.5% of patients were treated by mouthwash
antiseptic. In post-operative, apart from antibiotics largely prescribed (84.1%),
antiseptics gel was prescribed associated or not to mouthwash, for 99% of patients.
At the follow up visit (between 7 and 21 days after surgery), the mean plaque index
was 0.79±0.66 and the mean of gingival index was 0.61±0.59. Dentists were very
satisfied with the oral antiseptic gel utilisation (9.3±1.4). Conclusions: Results
show a very wide use of the oral antiseptic gel in Bulgaria during post-operative
treatment period. This practice leads to an excellent clinical outcomes with very
low scores of plaque index and gingival index. Therefore, we need further
investigations and analysis to summarize the recommendations of the use of the oral
antiseptic gel like a good practice reference.
AN - rayyan-563560329
AU - Shuleva, S.
AU - Zkik, A.
AU - Chalem, Y.
IS - 7
mouthwash
adult
Bulgaria
clinical outcome
controlled study
dentist
drug therapy
follow up
gingival index
human
implant
longitudinal study
middle aged
periodontal disease
postoperative care
prescription
satisfaction
sex ratio
surgery
wound
LA - English
PY - 2016
SN - 1524-4733
SP - A562
ST - Current perioperative use of orodental antiseptics in implant surgery in
Bulgaria
T2 - Value Health
TI - Current perioperative use of orodental antiseptics in implant surgery in
Bulgaria
VL - 19
ID - 13703
ER -
TY - JOUR
AB - AIM: This study aimed to compare the effects of subgingival delivery of 2%
curcumin gel and 0.2% chlorhexidine gel as an adjunct to scaling and root planing
(SRP) on clinical and microbiological parameters in the management of patients with
chronic periodontitis. MATERIALS AND METHODS: In total, 25 systemically healthy
individuals with age group ≥30 years diagnosed with chronic periodontitis were
included in the study. The study was a double-blind split-mouth randomized control
clinical trial. Two sites were selected in each patient and were randomly allocated
to experimental and control sites. At baseline, measurements of site-specific
periodontal parameters and collection of subgingival plaque sample were done. After
full-mouth SRP, subgingival delivery of 2% curcumin gel in experimental sites and
0.2% chlorhexidine gel in control sites was done. At 1 and 3 months, subgingival
plaque samples were collected again and site-specific periodontal parameters were
measured. RESULTS: The experimental group (2% curcumin gel) showed statistically
significant improvements in periodontal [i.e., sulcus bleeding index (SBI), probing
pocket depth (PPD), and relative attachment level (RAL)] and microbiologic
parameters in the form of colony-forming units (CFUs) in comparison with control
group (0.2% chlorhexidine gel). CONCLUSION: Subgingival delivery of curcumin has
shown effective anti-inflammatory and antibacterial properties. Since it is
biologically accepted by the patients and its delivery in periodontal pockets can
be recommended as an adjunct to SRP therapy for the treatment of patients with
localized, moderate chronic periodontitis and in patients under the periodontal
maintenance phase. CLINICAL SIGNIFICANCE: Curcumin being a herbal agent may be
excellent alternative to chlorhexidine. It is biologically accepted by the patients
and can be recommended as an adjunct to SRP in the treatment of localized moderate
chronic periodontitis and periodontal maintenance patients.
AN - rayyan-563560125
AU - Siddharth, M.
AU - Singh, P.
AU - Gupta, R.
AU - Sinha, A.
AU - Shree, S.
AU - Sharma, K.
DO - 10.5005/jp-journals-10024-2828
IS - 5
KW - chlorhexidine
curcumin
dental scaling
human
root planing
LA - English
PY - 2020
SN - 1526-3711
SP - 494-499
ST - A Comparative Evaluation of Subgingivally Delivered 2% Curcumin and 0.2%
Chlorhexidine Gel Adjunctive to Scaling and Root Planing in Chronic Periodontitis
TI - A Comparative Evaluation of Subgingivally Delivered 2% Curcumin and 0.2%
VL - 21
ID - 13499
ER -
TY - JOUR
AN - rayyan-563561689
AU - Siddharth, M.
AU - Singh, P.
AU - Gupta, R.
AU - Sinha, A.
AU - Shree, S.
AU - Sharma, K.
DO - 10.5005/JP-JOURNALS-10024-2828
IS - 5
PY - 2020
SP - 494-499
ST - Comparative Evaluation of Subgingivally Delivered 2% Curcumin and 0.2%
T2 - Journal of Contemporary Dental Practice
TI - Comparative Evaluation of Subgingivally Delivered 2% Curcumin and 0.2%
85088351244&doi=10.5005%2fJP-JOURNALS-10024-
2828&partnerID=40&md5=83a6e3b70009312ccb3d37321ccf0fb3
VL - 21
ID - 15063
ER -
TY - JOUR
AB - O objetivo do presente trabalho foi verificar, in vitro, o efeito
antimicrobiano dessas soluções sobre duas espécies bacterianas causadoras de doença
periodontal. Método: As tinturas e as soluções de clorexidina a 0,12 por cento como
grupo controle positivo, e álcool de cereais, utilizado no preparo das tinturas,
como controle negativo, foram diluídas em solução salina de 1:2 até 1:128.
Utilizando o método da difusão em agar,as cepas de referência Porphyromonas
gingivales ATCC 49417 e Prevotella melaninogenica ATCC 25845, foram semeadas em
meio BHI agar enriquecido com extrato de levedura (0,5 por cento) e incubadas em
anaerobiose, à 37º C durante 3 dias.Resultados: Os resultados demonstraram que a
Tanchagem e a Sálvia possuem ação antibacteriana sobre as duas cepas em teste,
assim como a clorexidina. Porém a tintura de Ipê-roxonão interferiu no crescimento
de P. gingivales, sendo P.melaninogenica única sensível a esta tintura. As cepas
apresentaram-se resistentes ao álcool de cereais. Conclusão:Conclui-se que as
tinturas de tanchagem e sálvia apresentam maior espectro de atuação antibacteriana,
quando comparadas à tintura de Ipê-roxo, sendo seu efeito não influenciado pelo
álcool utilizado na sua fabricação
AN - rayyan-563559886
AU - Silva, Naiana Braga da
AU - Claudino, Lígia Vieira
AU - Neves, Alyne Santos
AU - Costa, Adalberto Coelho da
AU - Valença, Ana Maria Gondim
IS - 2
LA - pt
PY - 2006
SN - 1519-0501
SP - 167-171
ST - Avaliação da atividade antimicrobiana de tinturas fitoterápicas sobre
porphyromonas gingivales e prevotella melaninogênica
T2 - Pesqui. bras. odontopediatria clín. integr
TI - Avaliação da atividade antimicrobiana de tinturas fitoterápicas sobre
porphyromonas gingivales e prevotella melaninogênica
UR - https://pesquisa.bvsalud.org/portal/resource/pt/biblio-853709
VL - 6
Y2 - 10 y3 - 1
ID - 13260
ER -
TY - JOUR
AB - The oral cavity is colonized by several species of microorganisms that can
cause dental caries, periodontal diseases, candidiasis, endodontic infections, and,
among other diseases related to the dental field. Conventional treatment consists
of mechanical removal associated with systemic administration of antimicrobials,
which can cause various side effects and microbial resistance. In this context,
alternative therapies have been developed, including Antimicrobial Photodynamic
Therapy (aPDT). For the improvement of therapy, the implementation of
nanotechnology is very important to optimize the delivery system of the dyes or
photosensitizers on biological targets. Besides, this combination provides a non-
invasive treatment, better solubility and bioavailability, delivery to the target
site, controlled release and protection against external and physical–chemical
factors, low side effects, and, unlikely resistant species. Although, there are
numerous researches on aPDT and nanotechnology, few review articles based on the
combination of these three aspects: nanosystems, aPDT and oral infections are
available. For this reason, this article aims to discuss the advances and
advantages of this combination. Therefore, this article was divided into different
types of nanosystems (organic and inorganic nanoparticles) associated with aPDT
bringing a description of it is definitions, properties, and, applications in oral
infections.
AN - rayyan-563560027
AU - Silvestre, A. L. P.
AU - Di Filippo, L. D.
AU - Besegato, J. F.
AU - de Annunzio, S. R.
AU - Almeida Furquim de Camargo, B.
AU - de Melo, P. B. G.
AU - Rastelli, A. N. D. S.
AU - Fontana, C. R.
AU - Chorilli, M.
DO - 10.1016/j.ijpharm.2020.120078
cyclodextrin derivative
hydrogel
liposome
metal nanoparticle
nanoparticle
polymer
quantum dot
human
mouth infection
nanoemulsion
nanopharmaceutics
nonhuman
polymerization
priority journal
review
LA - English
PY - 2021
SN - ["1873-3476", "0378-5173"]
ST - Current applications of drug delivery nanosystems associated with
antimicrobial photodynamic therapy for oral infections
T2 - Int. J. Pharm.
TI - Current applications of drug delivery nanosystems associated with
antimicrobial photodynamic therapy for oral infections
VL - 592
ID - 13401
ER -
TY - JOUR
AN - rayyan-563560934
AU - Sinclair, G.
doxycycline
article
gel
human
periodontitis
LA - English
PY - 2000
SN - 0158-1570
SP - 157-158
ST - The A-X of Atridox
T2 - Ann R Australas Coll Dent Surg
TI - The A-X of Atridox
VL - 15
ID - 14308
ER -
TY - JOUR
AB - Conventional treatments for common disorders of the oral mucous membranes
have great challenges, and this has motivated the development of local therapeutics
with an advanced delivery platform. The present study aimed to develop a hydrogel
containing clotrimazole‒rosehip oil nanoethosomes (CZ-RO-NE) and to evaluate its
antibacterial and antifungal efficacy and ulcer index. Optimization of CZ-RO-NE was
performed by the Box‒Behnken statistical design using L-α-phosphatidylcholine, CZ,
and RO as independent variables. The optimized formulations were characterized for
their rheological properties, in vitro release characteristics, and ex vivo
permeability. An optimized formulation was fabricated using the thin-layer
evaporation technique where the rheological property indicated non-Newtonian flow.
The in vitro release profile of the formulations showed a significantly higher
release (80 ± 6.723%) from the CZ-RO-NE‒embedded hydrogel compared with the
marketed formulation and drug suspension (p <.05). Concurrently, the ex vivo
permeation of the drug through a sheep buccal membrane was highest for the CZ-RO-NE
(950 ± 43 μg/cm2), with a steady-state flux of 4.544 μg/cm2.min. Finally, the
antifungal effect against Candida albicans and antibacterial effect against
streptococci revealed a significantly higher zone of inhibition (23 ± 2 mm and 15 ±
1 mm, respectively) when compared with the marketed formulation of CZ (13 ± 2 mm
and 5 ± 2 mm, respectively). The antimicrobial efficacy of the optimized
formulation was further reflected by a significant reduction in oral ulcers in
experimental animals (0.5 ± 0.39 mm) when compared with the marketed formulation of
CZ (2.5 ± 0.45). These interesting results are evidence of the effective treatment
of oro-mucosal ulcers by this CZ-RO-NE hydrogel and the superior compliance of
patients using the treatment.
AN - rayyan-563559987
AU - Sindi, A. M.
AU - Alharbi, W. S.
AU - Alkhalidi, H. M.
AU - Alghaith, A. F.
AU - Hosny, K. M.
DO - 10.1016/j.jddst.2021.102482
KW - antifungal agent
antiinfective agent
clotrimazole
dexamethasone
hydrogel
nanoethosomal gel
phosphatidylcholine
rosehip oil
tetracycline
unclassified drug
vegetable oil
animal experiment
animal model
animal tissue
antifungal activity
article
Candida albicans
controlled study
drug efficacy
drug formulation
drug release
ex vivo study
gingivitis
in vitro study
independent variable
male
nonhuman
rat
steady state
Streptococcus
suspension cell culture
thrush
ulcer index
zone of inhibition
LA - English
PY - 2021
SN - 1773-2247
ST - Development and optimization of Clotrimazole‒Rosehip oil nanoethosomal-gel
for oral thrush and gingivitis
TI - Development and optimization of Clotrimazole‒Rosehip oil nanoethosomal-gel
for oral thrush and gingivitis
VL - 63
ID - 13361
ER -
TY - JOUR
AB - Numerous problems affect oral health, and intensive research is focused on
essential oil–based nanoemulsions that might treat prevent or these problems.
Nanoemulsions are delivery systems that enhance the distribution and solubility of
lipid medications to targeted locations. Turmeric (Tur)- and curry leaf oil (CrO)–
based nanoemulsions (CrO-Tur-self-nanoemulsifying drug delivery systems [SNEDDS])
were developed with the goal of improving oral health and preventing or treating
gingivitis. They could be valuable because of their antibacterial and anti-
inflammatory capabilities. CrO-Tur-SNEDDS formulations were produced using the
response surface Box-Behnken design with different concentrations of CrO (120, 180,
and 250 mg), Tur (20, 35, and 50 mg), and Smix 2:1 (400, 500, and 600 mg). The
optimized formulation had a bacterial growth inhibition zone of up to 20 mm,
droplet size of less than 140 nm, drug-loading efficiency of 93%, and IL-6 serum
levels of between 950 ± 10 and 3000 ± 25 U/ml. The optimal formulation, which
contained 240 mg of CrO, 42.5 mg of Tur, and 600 mg of Smix 2:1, was created using
the acceptable design. Additionally, the best CrO-Tur-SNEDDS formulation was
incorporated into a hyaluronic acid gel, and thereafter it had improved ex-vivo
transbuccal permeability, sustained in-vitro release of Tur, and large bacterial
growth suppression zones. The optimal formulation loaded into an emulgel had lower
levels of IL-6 in the serum than the other formulations evaluated in rats.
Therefore, this investigation showed that a CrO-Tur-SNEDDS could provide strong
protection against gingivitis caused by microbial infections.
AN - rayyan-563559766
AU - Sindi, A. M.
AU - Hosny, K. M.
AU - Rizg, W. Y.
AU - Sabei, F. Y.
AU - Madkhali, O. A.
AU - Bakkari, M. A.
AU - Alfayez, E.
AU - Alkharobi, H.
AU - Alghamdi, S. A.
AU - Banjar, A. A.
AU - Majrashi, M.
AU - Alissa, M.
DO - 10.1080/10717544.2023.2184311
IS - 1
KW - orthodontic wire
chloral hydrate
curry oil
essential oil
hyaluronic acid
interleukin 6
nanoemulgel
nanogel
turmeric
unclassified drug
adult
animal experiment
animal model
animal tissue
article
bacterial growth
Box Behnken design
controlled study
drug formulation
drug solubility
drug stability
ex vivo study
experimental design
gingivitis
growth inhibition
in vitro study
male
nanoemulsion
nonhuman
particle size
protein blood level
rat
self nanoemulsifying drug delivery system
wound healing
zone of inhibition
LA - English
PY - 2023
SN - ["1521-0464", "1071-7544"]
ST - Utilization of experimental design in the formulation and optimization of
hyaluronic acid–based nanoemulgel loaded with a turmeric–curry leaf oil
nanoemulsion for gingivitis
T2 - Drug Deliv.
TI - Utilization of experimental design in the formulation and optimization of
hyaluronic acid–based nanoemulgel loaded with a turmeric–curry leaf oil
nanoemulsion for gingivitis
VL - 30
ID - 13140
ER -
TY - JOUR
AB - Mucoadhesion is the most vital concept that is widely utilized in most of the
novel drug delivery systems via mucosal membrane of buccal, nasal, digestive tract,
etc when administered through oral, nasal or any other route. This review deals
with the basic concept of sustained release mucoadhesive microspheres, their
preparation methods, recent patents on sustained release microspheres and finally
the various marketed formulations of microspheres. The mucoadhesive microspheres
prepared by different techniques are widely used in sustained delivery of drugs
with improved bioavailability and targeting efficacy. The listed patents contain
the methods developed for microsphere preparation along with the encapsulated
material that needs to be delivered. In short the patents listed here also gave the
information of the polymers utilized for the microsphere preparation along with
their therapeutic efficacy. © 2011 Bentham Science Publishers.
AN - rayyan-563560533
AU - Singh, A.
AU - Sharma, P. K.
AU - Malviya, R.
DO - 10.2174/1877913111202010062
IS - 1
KW - angiopeptin
bromocriptine
bromocriptine mesilate
buserelin
buserelin acetate
goserelin
leuprorelin
microsphere
minocycline
naltrexone
octreotide
posilac
recombinant somatomedin B
risperidone
triptorelin
unclassified drug
acromegaly
alcoholism
article
bipolar I disorder
coacervation
cross linking
diffusion
drug absorption
drug efficacy
drug formulation
drug marketing
drug synthesis
drug targeting
emulsion
endometriosis
evaporation
growth retardation
human
hydrogel
hydrophilicity
microencapsulation
mucoadhesion
parkinsonism
patent
periodontitis
polymerization
priority journal
prostate cancer
schizophrenia
solvent effect
spray drying
suspension
arestin
consta
decapeptyl
enantone depot
lupron depot
nutropin depot
parlodel lar
risperdal
somatuline
suprecur
trelstar depot
trenantone
vivitrol
zoladex
LA - English
PY - 2012
SN - ["1877-9123", "1877-9131"]
SP - 62-77
ST - Sustained drug delivery using mucoadhesive microspheres: The basic concept,
preparation methods and recent patents
T2 - Recent Pat. Nanomedicine
TI - Sustained drug delivery using mucoadhesive microspheres: The basic concept,
preparation methods and recent patents
VL - 2
ID - 13907
ER -
TY - JOUR
AB - Periodontal diseases are complex bacterial infections which needs a combined
antimicrobial approach to get rid of it. Lately various newer treatment modalities
have come for the management of periodontal diseases, Antimicrobial therapy is one
of them, but due to several adverse effects with systemic antibiotics-locally
delivered agents were introduced. Local administration of drugs directly into the
pocket provides greater concentration of drugs directly and reduces the side
effects; Local application of antimicrobial agents reaches to a level of about 32-
64 micrograms/ml. which is not achievable through systemic route. In the presence
of locally confined target organisms, local therapy may be particularly successful,
whereas systemic administration may reach widely distributed microorganisms. This
paper is aimed at reviewing the role & effectiveness of local drug delivery systems
in periodontal diseases.
AN - rayyan-563560363
AU - Singh, D. K.
IS - 2
KW - acrylic cellulose
antibiotic agent
cellulose
drug vehicle
ethyl cellulose
unclassified drug
article
biodegradability
drug contraindication
drug indication
drug release
gel
local drug delivery system
periodontal disease
periodontics
LA - English
PY - 2016
SN - 0975-8585
SP - 813-820
ST - Local drug delivery systems in periodontics: Aiming the target
TI - Local drug delivery systems in periodontics: Aiming the target
VL - 7
ID - 13737
ER -
TY - JOUR
AB - Purpose: To assess the clinical and biological effect of locally-administered
controlled-release 10 % doxycycline hyclate gel in smokers and non-smokers for the
management of periodontitis. Methods: Forty periodontitis patients were enrolled in
this study from December 2012 to February 2013 at the Department of Periodontology
and Implantology of the Institute of Dental Sciences and Dental Unit of Rohilkhand
Medical College, Bareilly, Uttar Pradesh (UP), India. For each patient, probing
pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), gingival
index (GI), and sulcular bleeding index (SBI) were recorded. Changes in microbial
counts were assessed by measuring colony-forming units (CFU) of three major
periodontal pathogens. Clinical and microbial parameters were recorded at baseline
and one month after scaling and root planing plus controlled local drug delivery of
10 % doxycycline hyclate gel in smokers and non-smokers. Results: A statistically
significant change (p < 0.01) in PPD was observed among smokers between baseline
(4.26 ± 0.12mm) and re-evaluation at one month (3.20 ± 0.11) with a change of 24.88
%. A statistically significant difference was found between smokers and non-smokers
in PPD at the end of a 1-month re-evaluation (p < 0.05). None of the other
parameters showed improvement in smokers following treatment. Conclusion: These
results indicate that 10 % doxycycline hyclate gel, when administered locally into
the periodontal pocket, shows clinical and microbial improvement, among smokers and
non-smokers, in the management of periodontitis. Therefore, 10 % doxycycline gel is
potentially an effective therapeutic strategy in the management of periodontitis.
AN - rayyan-563560050
AU - Singh, G.
AU - Gokhale, S. T.
AU - Manjunath, S.
AU - Nagate, R. R.
AU - Venkataram, V.
AU - Joseph, B.
DO - 10.4314/tjpr.v20i8.27
IS - 8
erythromycin
gel
tetracycline
adult
article
biological activity
bleeding
clinical article
colony forming unit
controlled study
debridement
dental caries
dental parameters
dental scaling
drug formulation
erythema
female
gingival index
human
male
middle aged
non-smoker
periodontal pocket
periodontitis
pilot study
plaque index
root planing
smoking
sulcular bleeding index
tooth plaque
LA - English
PY - 2021
SN - ["1596-9827", "1596-5996"]
SP - 1739-1747
ST - Evaluation of locally-administered controlled-release doxycycline hyclate gel
in smokers and non-smokers in the management of periodontitis: An Indian study
TI - Evaluation of locally-administered controlled-release doxycycline hyclate gel
in smokers and non-smokers in the management of periodontitis: An Indian study
VL - 20
ID - 13424
ER -
TY - JOUR
AB - Background: Mycobacterium species, specifically M. abscessus and M. chelonae
(MABs), are known to contaminate water systems and are uncommon causes of health
care-Associated infection, but morbidity can be significant and treatment complex.
Methods: Odontogenic MAB infections occurred in patients following pulpotomy
procedures at dental clinic A from 1 January to 6 September 2016. We identified
confirmed and probable cases using culture data, imaging, pathology results, and
surgical findings. Epidemiologic and clinical data including demographics,
symptoms, laboratory findings, treatment regimens, and outcomes were extracted.
Results: Of 1082 at-risk patients, 71 case patients (22 confirmed; 49 probable)
were identified. Median age was 6 years. Median symptom onset was 85 days
postpulpotomy. Pain and/or swelling on admission occurred in 79%. On imaging, 49 of
70 had abnormalities of the mandible or maxilla, 13 of 70 had lymphadenopathy, and
19 of 68 had pulmonary nodules. Seventy were hospitalized (average of 8.5 days).
Intravenous antibiotics were administered to 32 cases for a median length of 137
days. Clofazimine was administered to 29 patients as part of their multidrug
regimen. Antibiotic treatment was associated with many adverse effects. Treated
children showed evidence of jaw healing with resolved/improving pulmonary nodules
at 1-year follow-up. Conclusions: This is the largest outbreak of invasive MAB
infections associated with a pediatric dental practice. While infections were
indolent, patients suffered medical and surgical consequences of treatment,
including permanent tooth loss. Identification of this outbreak led to a change in
water standards for pediatric dental procedures in California. Enhanced national
dental water quality standards are needed to prevent future outbreaks.
AN - rayyan-563559990
AU - Singh, J.
AU - O'Donnell, K.
AU - Nieves, D. J.
AU - Adler-Shohet, F. C.
AU - Arrieta, A. C.
AU - Ashouri, N.
AU - Ahuja, G.
AU - Cheung, M.
AU - Holmes, W. N.
AU - Huoh, K.
AU - Tran, L.
AU - Tran, M. T.
AU - Pham, N.
AU - Zahn, M.
DO - 10.1093/ofid/ofab165
IS - 6
KW - peripherally inserted central venous catheter
amikacin
amoxicillin
antibiotic agent
azithromycin
cefoxitin
clavulanic acid
clindamycin
clofazimine
gelatin
imipenem
liver enzyme
tigecycline
abdominal pain
acid fast bacterium
antibiotic therapy
article
atypical Mycobacterium
child
chronic osteomyelitis
controlled study
creatinine blood level
debridement
demography
dental clinic
dental practice
dental surgeon
diarrhea
drug combination
drug dose reduction
drug monitoring
extraction
female
fever
fine needle aspiration biopsy
follow up
granulomatosis
granulomatous inflammation
healing
hearing impairment
hospitalization
hospitalized child
human
human experiment
hyperpigmentation
imaging
jaw
lung nodule
lymph node dissection
lymphadenopathy
male
mandible
maxilla
medical record review
Mycobacterium abscessus
nausea and vomiting
neck dissection
neutropenia
osteomyelitis
pain
patient safety
pediatric hospital
periodontal disease
permanent tooth
preschool child
pulpotomy
radiography
skin manifestation
social status
swelling
symptom
thorax radiography
tooth extraction
tooth infection
water quality
water standard
LA - English
PY - 2021
SN - 2328-8957
ST - Invasive mycobacterium abscessus outbreak at a pediatric dental clinic
T2 - Open Forum Infect. Dis.
TI - Invasive mycobacterium abscessus outbreak at a pediatric dental clinic
VL - 8
ID - 13364
ER -
TY - JOUR
AB - Aim: The aim of the present work was to explore the development of a dual-
controlled release periodontal system of a potent broad spectrum first-generation
fluoroquinolone, ciprofloxacin, and the anti-inflammatory enzyme serratiopeptidase
(STP). Materials and Methods: Based on 3 2 full factorial design, thermoreversible
periodontal sols capable of controlled dual delivery of ciprofloxacin hydrochloride
and STP were designed using pluronic F127 and carbopol 934P as thermosensitive
gelling polymers. Sol gel transition characteristics, %cumulative drug release at
48 th h and exvivo mucoadhesive strength were designated as dependent responses.
The sols were mucoadhesive, syringeable, and inverted into gels at simulated
periodontal cavity temperature. Results: F9 with optimal drug release was
identified as the best formulation. Extra design check point generated using Design
Expert software 8.02 (Stat-Ease, USA) validated the experimental design. Textural
analysis revealed that the developed sols were syringeable and spreadable enough
for periodontal treatment so it can be expected that hardness and compressibility
of sols would pose no problem during clinical application. The in vitro release
behavior exhibited controlled release of both cipro HCl and STP (>90% release).
Conclusion: A dual-controlled release thermoreversible periodontal sol of
ciproflaxin and STP was successfully developed. Incorporation of STP as anti-
inflammatory agent has the potential of developing a therapeutically efficacious
system of cipro HCl for treatment of periodontal inflammatory anaerobic infections.
AN - rayyan-563560434
AU - Singh, K.
AU - Chhabra, G.
AU - Sharma, V.
AU - Pathak, K.
DO - 10.4103/2230-973X.127734
IS - 1
KW - carbomer
ciprofloxacin
poloxamer
serratiopeptidase
article
compression
controlled study
drug analysis
drug design
drug stability
ex vivo study
gel
hardness
mouth temperature
nonhuman
priority journal
thermoreversible periodontal sol
LA - English
PY - 2014
SN - ["2230-973X", "2230-9713"]
SP - 5-14
ST - Thermosensitive periodontal sol of ciprofloxacin hydrochloride and
serratiopeptidase: Pharmaceutical and mechanical analysis
TI - Thermosensitive periodontal sol of ciprofloxacin hydrochloride and
serratiopeptidase: Pharmaceutical and mechanical analysis
VL - 4
ID - 13808
ER -
TY - JOUR
AB - Periodontitis is an inflammatory condition of teeth's supporting tissues due
to specific pathogens. Antibiotic delivery has already been studied in a bid to
overcome the drawbacks of standard treatments. The purpose of this research is to
prepare niosomes, which are then constructed into niosomal gels. Coacervation phase
separation was used to create the preparation. Entrapment efficiency, vesicle size,
surface morphology, and in in vitro drug release were all measured in prepared
formulation. Carbopol 934P and neem gum were used as gelling agents in the
preparation of the niosomal gel formulation.
AN - rayyan-563559919
AU - Singh, M.
DO - 10.14704/nq.2022.20.10.NQ55776
IS - 10
gelling agent
article
coacervation
controlled study
drug formulation
drug release
human
in vitro study
periodontitis
phase separation
surface property
LA - English
PY - 2022
SN - 1303-5150
SP - 7873-7882
ST - FORMULATION AND EVALUATION OF NEEM GUM NIOSOMAL GEL FOR THE TREATMENT OF
PERIODONTITIS
T2 - NeuroQuantology
TI - FORMULATION AND EVALUATION OF NEEM GUM NIOSOMAL GEL FOR THE TREATMENT OF
PERIODONTITIS
VL - 20
ID - 13293
ER -
TY - JOUR
AB - Chitosan is a cationic natural polysaccharide which is derived from the
chitin of crustaceans, with crabs and shrimp-shell wastes as its principal source.
Its properties includes extent of deacetylation and the average molecular weight of
polymer as well as low toxicity and good bioavailability make it a novel excipient
in pharmaceutical formulation as a relatively new development. Together with
chitin, chitosan is well thought-out the second most abundant polysaccharide
subsequent to cellulose. But in contrast to cellulose, the application of Chitosan
in pharmaceutical field is a pretty new development. Recently there are so many
formulation were prepared and evaluated within different dosage forms such as
ophthalmic, nasal sublingual, buccal, periodontal, gastrointestinal, colon
specific, vaginal, transdermal as well as gene carrier which is based on the
application of chitosan and its derivatives. Chitosan is biocompatible and show the
activities such as antimicrobial and antifungal activities, which makes it a
favourable option for biomedical applications. It has been proven to be useful in
tissue growth, in tissue repair and accelerating wound-healing and bone
regeneration. Microcrystalline chitosan (MCCh) is a highly crystalline grade of
chitosan base may be particularly valuable as an excipient. Mucoadhesive tendency
of chitosan might also depend on its crystallinity. Efficient gel formation by MCCh
could result in substantial mucoadhesion, at least as far as "adhesion by
hydration" is concerned. The objective of this review is to summarized the
application and formulation based on the chitosan and its derivatives and also to
elaborate the importance of chitosan in pharmaceutical field.
AN - rayyan-563560578
AU - Singh, M. K.
AU - Prajapati, S. K.
AU - Mahor, A.
AU - Rajput, N.
AU - Singh, R.
IS - 9
KW - acriflavine
antibiotic agent
bleomycin
buserelin
calcitonin
chitosan
chitosan derivative
colestyramine
cosmetic
diclofenac
estradiol
furosemide
ibuprofen
insulin
interferon
metronidazole
nanoparticle
naproxen
ofloxacin
paclitaxel
recombinant interleukin 2
tobramycin
tramadol
triclosan
complex formation
cross linking
crystallization
drug absorption
drug efficacy
drug formulation
drug release
drug solubility
drug stability
human
hydrogen bond
micelle
mucoadhesion
nonhuman
particle size
pH
physical chemistry
polymerization
review
structure analysis
zeta potential
floxal
tobrex
LA - English
PY - 2011
SN - ["2320-5148", "0975-8232"]
SP - 2266-2277
ST - Chitosan: A novel excipient in pharmaceutical formulation: A review
TI - Chitosan: A novel excipient in pharmaceutical formulation: A review
VL - 2
ID - 13952
ER -
TY - JOUR
AB - Pullulan, an α-glucan polysaccharide, is colorless, odorless, non-toxic, non-
carcinogenic, highly biocompatible, edible and biodegradable in nature. The long
chains of glucopyranose rings in pullulan structure are linked together by α-(1 →
4) and α-(1 → 6) glycosidic linkages. The occurrence of both glycosidic linkages in
the pullulan structure contributes to its distinctive properties. The unique
structure of pullulan makes it a potent candidate for both pharmaceutical and
cosmeceutical applications. In pharmaceuticals, it can be used as a drug carrier
and in various dosage formulations. It has been widely used in drug targeting,
implants, ocular dosage forms, topical formulations, oral dosage forms, and oral
liquid formulations, etc. Pullulan can be used as a potential carrier of active
ingredients and their site-specific delivery to skin layers for cosmeceutical
applications. It has been extensively used in cosmeceutical formulations like
creams, shampoo, lotions, sunscreen, facial packs, etc. The current review
highlights applications of pullulan in pharmaceutical and cosmeceutical
applications.
AN - rayyan-563559738
AU - Singh, R. S.
AU - Kaur, N.
AU - Singh, D.
AU - Purewal, S. S.
AU - Kennedy, J. F.
DO - 10.1016/j.ijbiomac.2023.123353
KW - alginic acid
amlodipine besylate
arabinogalactan
asialofetuin
captopril
chitosan
cosmeceutical
diclofenac
doxorubicin
gellan
glucopyranose
hydrogel
isomaltose
liposome
maltotriose
nanocarrier
nanofiber
polymer
polysaccharide
pullulan
shampoo
sunscreen
unclassified drug
atopic dermatitis
Aureobasidium pullulans
breast cancer
carbon nuclear magnetic resonance
cardiotoxicity
colorectal cancer
cytotoxicity
drug industry
fenugreek
gingivitis
human
hyperpigmentation
keratomycosis
lotion
microscopy
mouth hygiene
onychomycosis
review
skin protection
LA - English
PY - 2023
SN - ["1879-0003", "0141-8130"]
ST - Pullulan in pharmaceutical and cosmeceutical formulations: A review
TI - Pullulan in pharmaceutical and cosmeceutical formulations: A review
VL - 231
ID - 13112
ER -
TY - JOUR
AB - Objective: To assess the efficacy of a dentifrice containing 0.3%
triclosan/2.0% PVM/MA copolymer/0.243% sodium fluoride for controlling established
gingivitis and supragingival plaque relative to that of a dentifrice containing
0.454% stannous fluoride, sodium hexametaphosphate, and zinc lactate, and a
dentifrice containing 0.243% sodium fluoride as a negative control. Methods:
Following a baseline examination for gingivitis and supragingival plaque,
qualifying adult male and female subjects from the Piscataway, NJ, USA area were
randomized into three dentifrice groups. Subjects were instructed to brush their
teeth twice daily (morning and evening) for one minute with their assigned
dentifrice and a soft-bristled toothbrush. Examinations for gingivitis and
supragingival plaque were repeated after six weeks of product use. Results: One-
hundred and seventy-one (171) subjects complied with the protocol and completed the
study. Relative to the group using the dentifrice with 0.243% sodium fluoride
alone, the 0.3% triclosan/2.0% PVM/MA copolymer/0.243% sodium fluoride group
exhibited statistically significant reductions in gingival index and supragingival
plaque index scores of 25.3% and 33.0%, respectively, after six weeks of product
use. Similarly, relative to the group using the 0.243% sodium fluoride dentifrice,
the 0.454% stannous fluoride, sodium hexametaphosphate, and zinc lactate dentifrice
group exhibited statistically significant reductions in gingival index and plaque
index scores of 8.1% and 14.1% after six weeks of product use. Further, relative to
the 0.454% stannous fluoride, sodium hexametaphosphate, and zinc lactate dentifrice
group, the 0.3% triclosan/2.0% PVM/MA copolymer/0.243% sodium fluoride dentifrice
group exhibited statistically significant reductions in gingival index and plaque
index scores of 18.7% and 22%, respectively Conclusion: The overall results of this
double-blind clinical study support the conclusion that a dentifrice containing
0.3% triclosan/2.0% PVM/MA copolymer/0.243% sodium fluoride is efficacious for the
control of established gingivitis and supragingival plaque as compared to a regular
fluoride dentifrice, and that it provides a greater level of efficacy for the
control of gingivitis and supragingival plaque than does a dentifrice containing
0.454% stannous fluoride, sodium hexametaphosphate, and zinc lactate.
AN - rayyan-563560619
AU - Singh, S.
AU - Chaknis, P.
AU - DeVizio, W.
AU - Proskin, H. M.
IS - 4
sodium fluoride
phosphate
silicic acid
tin fluoride
toothpaste
triclosan
zinc derivative
adolescent
adult
aged
article
chemistry
drug combination
female
gingivitis
human
male
middle aged
nonparametric test
periodontics
tooth plaque
LA - English
PY - 2010
SN - 0895-8831
SP - 105-110
ST - A clinical investigation of the efficacy of three commercially available
dentifrices for controlling established gingivitis and supragingival plaque
T2 - J. Clin. Dent.
TI - A clinical investigation of the efficacy of three commercially available
dentifrices for controlling established gingivitis and supragingival plaque
VL - 21
ID - 13993
ER -
TY - JOUR
AB - Background: Dental plaque is a complex ecosystem which consists of densely
packed microbial colonies, microbial by-products, salivary glycoproteins and
desquamated epithelial cells. Clinical studies have proved the relationship between
plaque and periodontal disease. Aim: This study compares the anti-plaque efficacy
and anti-inflammatory potential of turmeric gel with 0.2% chlorhexidine gel along
with scaling and root planing (SRP). Materials and Methods: One hundred and fifty
individuals were selected and divided into three groups for the study. Group A was
instructed to use 0.2% chlorhexidine gel, whereas Group B used turmeric gel along
with SRP. Participants were assessed for plaque and gingivitis on the 14thand
21stdays. Subjective and objective criteria were assessed. The clinical data were
recorded and used for statistical analysis to obtain results. Results: The
percentage reduction of plaque index (PI) between the chlorhexidine and turmeric
gel on 21stday were 74.85 and 65.91 respectively. similarly, the percentage
reduction of gingival index (GI) between the chlorhexidine and turmeric gel on
21stday were 58.49 and 62.46 respectively. Conclusion: Turmeric gel shows a
slightly lower anti-plaque property in comparison to chlorhexidine gel. Their
effect on a reduction of gingival inflammation was equal. It was also noted that
turmeric gel showed better acceptability and biocompatibility by the participants.
AN - rayyan-563559991
AU - Singh, S.
AU - Kumar, B.
AU - Verma, S.
AU - Kumari, P.
AU - Singh, N.
DO - 10.4103/jpbs.JPBS_713_20
IS - 5
KW - chlorhexidine
mouthwash
turmeric
adult
article
controlled study
dental scaling
drug efficacy
evening dosage
female
gingival index
gingivitis
human
male
morning dosage
mouth hygiene
plaque index
root planing
tooth plaque
LA - English
PY - 2021
SN - 0975-7406
SP - S679-S683
ST - Comparative evaluation of anti-inflammatory efficacy of turmeric and
chlorhexidine gel as an adjunct to scaling and root planing in the treatment of
gingivitis
TI - Comparative evaluation of anti-inflammatory efficacy of turmeric and
chlorhexidine gel as an adjunct to scaling and root planing in the treatment of
gingivitis
VL - 13
ID - 13365
ER -
TY - JOUR
AN - rayyan-563561921
AU - Singh, Y.
AU - Vuddanda, P. R.
AU - Jain, A.
AU - Parihar, S.
AU - Chaturvedi, T. P.
AU - Singh, S.
DO - 10.1039/c5ra02350e
IS - 59
PY - 2015
SP - 47659-47670
ST - Mucoadhesive gel containing immunotherapeutic nanoparticulate satranidazole
for treatment of periodontitis: Development and its clinical implications
T2 - RSC Advances
TI - Mucoadhesive gel containing immunotherapeutic nanoparticulate satranidazole
for treatment of periodontitis: Development and its clinical implications
84930633107&doi=10.1039%2fc5ra02350e&partnerID=40&md5=86e06627365e205fbc6b8aa25dc43
892
VL - 5
ID - 15295
ER -
TY - JOUR
AB - AIM: Boric acid (BA) exhibits antibacterial, anti-inflammatory, as well as
osteoblastic, activity. The aim of the present study was to explore the efficacy of
0.75% BA gel as a local drug-delivery system in adjunct to scaling and root planing
(SRP) for the treatment of class II furcation defects in comparison with placebo
gel. METHODS: A total of 48 mandibular class II furcation defects were randomized
and treated with either 0.75% BA gel or placebo gel. Clinical parameters were
recorded at baseline, 3 months, and 6 months, while radiographic parameters were
recorded at baseline and 6 months. RESULTS: Greater mean probing depth reduction
and mean relative vertical and horizontal clinical attachment level gain were shown
to be greater in group 1 than in group 2 at 3 and 6 months. Furthermore, a
significantly greater mean percentage of bone fill was found in group 1 (16.98%
±1.03%) than in the placebo (2.86%±0.92%) at 6 months. CONCLUSION: The .75% BA
group showed significant improvement in clinical parameters compared to placebo gel
as an adjunct to SRP. This implies an alternative for treatment of class II
furcation.
AN - rayyan-563560268
AU - Singhal, S.
AU - Pradeep, A. R.
AU - Kanoriya, D.
AU - Garg, S.
AU - Garg, V.
DO - 10.1111/jicd.12279
IS - 1
KW - boric acid
adult
bone regeneration
controlled study
dental scaling
diagnostic imaging
drug effect
female
gel
human
male
mandible
middle aged
osteoblast
periodontal disease
periodontal index
periodontal pocket
plaque index
procedures
root planing
treatment outcome
LA - English
PY - 2018
SN - 2041-1626
ST - Boric acid gel as local drug delivery in the treatment of class II furcation
defects in chronic periodontitis: a randomized, controlled clinical trial
TI - Boric acid gel as local drug delivery in the treatment of class II furcation
defects in chronic periodontitis: a randomized, controlled clinical trial
VL - 9
ID - 13642
ER -
TY - JOUR
AN - rayyan-563561863
AU - Sinurat, D.
AU - Ervina, I.
AU - Hakim Bangun, D.
IS - 1
PY - 2014
SP - 223-227
ST - Formulation and in vitro evaluation of alginate based metronidazole
periodontal gel
T2 - Asian Journal of Pharmaceutical and Clinical Research
TI - Formulation and in vitro evaluation of alginate based metronidazole
periodontal gel
84891684774&partnerID=40&md5=7f06f3f46ad417fc02a0ff34a16fabb4
VL - 7
ID - 15237
ER -
TY - JOUR
AB - Objectives: The purpose of this split-mouth study was to evaluate the
clinical response of enamel matrix proteins (EMPs, Emdogain Gel®) in intra-osseous
defects with or without a combined application of a tetracycline-coated expanded
polytetrafluoroethylene barrier membrane (e-PTFE, Gore-Tex®). Methods: Twelve pairs
of intra-osseous periodontal defects in 11 patients received the application of
EMPs on the exposed root surface (EMP). One of the two defects received randomly,
as an adjunct to EMP treatment, a tetracycline-coated e-PTFE membrane (MEMP). At
baseline, 6- and 12-month probing pocket depth (PPD), clinical attachment level
(CAL) and probing bone level (PBL) were measured. Results: After 12 months, the EMP
defects showed a significant mean PPD reduction of 2.86 ± 0.75 mm, a mean gain in
CAL of 1.28 ± 2.04 mm, a mean PBL gain of 1.63 ± 1.21 mm and a mean increase of
recession (REC) of 1.56 ± 2.30 mm. The MEMP defects showed a significant mean PPD
reduction of 3.02 ± 1.55 mm, a mean gain in CAL of 1.65 ± 1.29 mm, a mean PBL gain
of 1.58 ± 1.92 mm and a mean increase of REC of 1.38 ± 1.63 mm. Except for
significantly more post-operative discomfort at the MEMP sites, no significant
differences were found between EMP and MEMP defects. Conclusion: Within the limits
of this study, it is concluded that in the treatment of intra-osseous defects with
EMP, the adjunctive use of a tetracycline-coated e-PTFE membrane failed to show
more gain of CAL and PBL. Copyright © Blackwell Munksgaard 2005.
AN - rayyan-563560786
AU - Sipos, P. M.
AU - Loos, B. G.
AU - Abbas, F.
AU - Timmerman, M. F.
AU - Van Der Velden, U.
DO - 10.1111/j.1600-051X.2005.00754.x
IS - 7
KW - enamel protein
matrix protein
adult
article
clinical article
controlled study
dental procedure
female
follow up
human
male
membrane
mouth hygiene
periodontal disease
periodontitis
statistical concepts
surgical technique
tooth root
LA - English
PY - 2005
SN - 0303-6979
SP - 765-772
ST - The combined use of enamel matrix proteins and a tetracycline-coated expanded
polytetrafluoroethylene barrier membrane in the treatment of intra-osseous defects
TI - The combined use of enamel matrix proteins and a tetracycline-coated expanded
polytetrafluoroethylene barrier membrane in the treatment of intra-osseous defects
VL - 32
ID - 14160
ER -
TY - JOUR
AB - The present clinical study was conducted to assess the bacterial reduction
after chemomechanical preparation using 0.12% chlorhexidine digluconate solution as
an irrigant and the additive antibacterial effect of intracanal dressing with
calcium hydroxide (Ca(OH)2) associated with 0.12% chlorhexidine digluconate gel.
According to stringent inclusion/exclusion criteria, 13 teeth with primary
intraradicular infections and chronic apical periodontitis were selected and
followed in the study. Bacterial samples were taken at the baseline (before
treatment) (S1), after chemomechanical preparation using chlorhexidine (CHX) as an
irrigant (S2), and after a 7-day dressing with Ca(OH)2/CHX paste (S3). Cultivable
bacteria recovered from infected root canals at the three stages were counted and
identified by means of 16S ribosomal RNA gene sequencing analysis. At S1, all
canals were positive for bacteria, with the mean number of 3.5 taxa per canal
(range, 2-9). At S2, 7 cases (53.8%) still harbored cultivable bacteria, with a
mean number of 1.7 taxon per canal (range, 1-4). At S3, only one case (7.7%) was
positive for the presence of bacteria. The great majority of taxa found in
posttreatment samples were gram-positive bacteria. A significantly high reduction
in bacterial counts was observed between S1 and S2 and S1 and S3 (p < 0.001). Also,
significant differences were observed for comparisons involving S2 and S3 samples
with regard to both quantitative bacterial reduction (p = 0.014) and number of
cases yielding negative cultures (p = 0.01). It was concluded that chemomechanical
preparation with 0.12% CHX solution as an irrigant significantly reduced the number
of intracanal bacteria but failed to render the canal free of cultivable bacteria
in about one half of the cases. Application of a 7-day intracanal dressing with
Ca(OH)2/CHX paste further increased significantly the number of cases yielding
negative cultures. © 2007 American Association of Endodontists.
AN - rayyan-563560746
AU - Rôças, I. N.
DO - 10.1016/j.joen.2007.01.008
IS - 5
KW - bacterial RNA
calcium hydroxide
chlorhexidine
adult
aged
article
drug effect
endodontics
female
human
male
methodology
microbiology
middle aged
nonparametric test
tooth pulp
tooth pulp disease
LA - English
PY - 2007
SN - 0099-2399
SP - 541-547
ST - Reduction in the Cultivable Bacterial Populations in Infected Root Canals by
a Chlorhexidine-based Antimicrobial Protocol
T2 - J. Endod.
TI - Reduction in the Cultivable Bacterial Populations in Infected Root Canals by
a Chlorhexidine-based Antimicrobial Protocol
VL - 33
ID - 14120
ER -
TY - JOUR
calcium hydroxide (Ca(OH)(2)) associated with 0.12% chlorhexidine digluconate gel.
According to stringent inclusion/exclusion criteria, 13 teeth with primary
irrigant (S2), and after a 7-day dressing with Ca(OH)(2)/CHX paste (S3). Cultivable
in bacterial counts was observed between S1 and S2 and S1 and S3 (p<0.001). Also,
with regard to both quantitative bacterial reduction (p=0.014) and number of cases
yielding negative cultures (p=0.01). It was concluded that chemomechanical
Ca(OH)(2)/CHX paste further increased significantly the number of cases yielding
negative cultures.
AN - rayyan-563561428
AU - Paiva, S. S.
AU - Rôças, I. N.
DO - 10.1016/j.joen.2007.01.008
IS - 5
J2 - J Endod
KW - Adult
Aged
Calcium Hydroxide/therapeutic use
Dental Pulp Cavity/drug effects/*microbiology
Enterococcus faecalis/drug effects/*isolation & purification
Female
Humans
Male
Middle Aged
RNA, Bacterial/drug effects/*isolation & purification
Root Canal Therapy/methods
Tooth, Nonvital/drug therapy/microbiology
LA - eng
N1 - Department of Endodontics, Faculty of Dentistry, Estácio de Sá University,
Rio de Janeiro, RJ, Brazil. jf_siqueira@yahoo.com
PY - 2007
SN - 0099-2399 (Print)
SP - 541-7
ST - Reduction in the cultivable bacterial populations in infected root canals by
a chlorhexidine-based antimicrobial protocol
T2 - Journal of endodontics
TI - Reduction in the cultivable bacterial populations in infected root canals by
VL - 33
Y2 - 5
ID - 14802
ER -
TY - JOUR
calcium hydroxide (Ca(OH)(2)) associated with 0.12% chlorhexidine digluconate gel.
According to stringent inclusion/ exclusion criteria, 13 teeth with primary
irrigant (S2), and after a 7-day dressing with Ca(OH)(2)/CHX paste (S3). Cultivable
in bacterial counts was observed between S1 and S2 and S1 and S3 (p < 0.001). Also,
with regard to both quantitative bacterial reduction (p = 0.014) and number of
cases yielding negative cultures (p = 0.01). It was concluded that chemomechanical
Ca(OH)(2)/CHX paste further increased significantly the number of cases yielding
negative cultures.
AN - rayyan-563562407
AU - Rocas, I. N.
DO - 10.1016/j.joen.2007.01.008
IS - 5
PY - 2007
SN - 0099-2399
SP - 541-547
ST - Reduction in the cultivable bacterial populations in infected root canals by
TI - Reduction in the cultivable bacterial populations in infected root canals by
VL - 33
Y2 - 5
ID - 15781
ER -
TY - JOUR
AB - Aim To compare five calcium hydroxide (CH) products, CH-gutta-percha Plus
points (R) (CHGP) and conventional CH paste, for their ability to maintain
alkalinity and to assess the clinical antimicrobial effect of CHGP. Methodology
Calcium hydroxide products were tested in the presence of standardized dentine
powder or by titrating them with 1 mol HCl, expressed in mL (+/- SD). In a clinical
trial, 21 single-rooted teeth with primary apical periodontitis were medicated with
CHGP or with conventional CH paste. Bacterial samples were taken before and after
chemo-mechanical preparation, after dressing and after leaving canals empty but
sealed. To compare groups, ANOVA with Tukey's test was used in the laboratory study
and Fisher's exact test in the clinical study. Significance level was set at 5%.
Results Pure CH with water (8.5 +/- 0.1) and Calasept (9.3 +/- 0.1) maintained the
highest alkalinity, followed by the gel-like products DS CaOH gel (7.3 +/- 0.3) and
Ultracal XS (6.8 +/- 0.2) and then Biokalkki (6.3 +/- 0.3) and Calxyl blue (5.1 +/-
0.2). All CH paste products had higher values compared with CHGP (1.6 +/- 0.1) (P <
0.05). Saturated solutions of the products were all neutralized to pH 8.6 within 24
h by dentine powder addition. Clinically, culture-negative results were obtained in
5/10 canals in the CHGP group and 7/11 with conventional CH (P > 0.05). Conclusions
Aqueous CH mixtures kept high pH better than viscous gel products or CHGP. Dentine
powder had equal buffering effect on each product tested. CHGP and traditional CH
paste both had an antimicrobial effect in the clinical setting, but there was no
significant difference between the groups.
AN - rayyan-563562559
AU - Siren, E. K.
AU - Kerosuo, E.
AU - Lavonius, E.
AU - Meurman, J. H.
AU - Haapasalo, M.
DO - 10.1111/iej.12199
IS - 7
PY - 2014
SN - ["0143-2885", "1365-2591"]
SP - 628-638
ST - Ca(OH)(2) application modes: in vitro alkalinity and clinical effect on
bacteria
TI - Ca(OH)(2) application modes: in vitro alkalinity and clinical effect on
bacteria
VL - 47
Y2 - 7
ID - 15933
ER -
TY - JOUR
AB - AIM: To compare five calcium hydroxide (CH) products, CH-gutta-percha Plus
points(®) (CHGP) and conventional CH paste, for their ability to maintain
alkalinity and to assess the clinical antimicrobial effect of CHGP. METHODOLOGY:
Calcium hydroxide products were tested in the presence of standardized dentine
powder or by titrating them with 1 mol HCl, expressed in mL (±SD). In a clinical
trial, 21 single-rooted teeth with primary apical periodontitis were medicated with
CHGP or with conventional CH paste. Bacterial samples were taken before and after
chemo-mechanical preparation, after dressing and after leaving canals empty but
sealed. To compare groups, anova with Tukey's test was used in the laboratory study
and Fisher's exact test in the clinical study. Significance level was set at 5%.
RESULTS: Pure CH with water (8.5 ± 0.1) and Calasept (9.3 ± 0.1) maintained the
highest alkalinity, followed by the gel-like products DS CaOH gel (7.3 ± 0.3) and
Ultracal XS (6.8 ± 0.2) and then Biokalkki (6.3 ± 0.3) and Calxyl blue (5.1 ± 0.2).
All CH paste products had higher values compared with CHGP (1.6 ± 0.1) (P < 0.05).
Saturated solutions of the products were all neutralized to pH 8.6 within 24 h by
dentine powder addition. Clinically, culture-negative results were obtained in 5/10
canals in the CHGP group and 7/11 with conventional CH (P > 0.05). CONCLUSIONS:
Aqueous CH mixtures kept high pH better than viscous gel products or CHGP. Dentine
powder had equal buffering effect on each product tested. CHGP and traditional CH
paste both had an antimicrobial effect in the clinical setting, but there was no
significant difference between the groups.
AN - rayyan-563560422
AU - Sirén, E. K.
AU - Kerosuo, E.
AU - Lavonius, E.
AU - Meurman, J. H.
AU - Haapasalo, M.
DO - 10.1111/iej.12199
IS - 7
KW - alkali
calcium hydroxide
bacterium
chemistry
drug effect
human
in vitro study
pH
LA - English
PY - 2014
SN - 1365-2591
SP - 628-638
ST - Ca(OH)2 application modes: in vitro alkalinity and clinical effect on
bacteria
T2 - Int Endod J
TI - Ca(OH)2 application modes: in vitro alkalinity and clinical effect on
bacteria
VL - 47
ID - 13796
ER -
TY - JOUR
AB - Background and Aim: The aim of our study was to investigate whether full
mouth disinfection decreases the size of periodontal wound and periodontal
inflammatory burden and also whether it lowers the serum levels of C-reactive
protein. Methods: We included 20 subjects (11 women and 9 men) 30- 68 years
(average 48-years) old with generalised periodontitis (stage 3, grade C) in our
study. The size of the periodontal wound and periodontal inflammatory burden was
measured with the application Periodontal wound on the basis of measurements of
average teeth neck circumferences, and probing depths and bleeding on probing
assesed at six sites around each tooth in the oral cavity. The levels of CRP were
measured with an immunochemical method. All three parameters were measured before
treatment and 3 months after therapy. The full mouth disinfection included removal
of plaque and calculus with ultrasonic and hand instruments in one session.
Furthermore, the tongue was brushed with a 1% chlorhexidine gel for 1 min and the
mouth was rinsed with a 0.2% chlorhexidine solution for 2 min. All pockets were
rinsed with 0.2% chlorhexidine. After periodontal therapy, patients were advised to
rinse with 0.2% chlorhexidine twice a day for 2 weeks. Results: The results showed
a decrease in periodontal wound size (for 8.74 cm2) and periodontal inflammatory
burden (for 7.41 cm2) and lower CRP levels (for 0.5 mg/ml) 3 months after therapy.
Conclusions: Full mouth disinfection leads to a smaller periodontal wound and
periodontal inflammatory burden and also to a decrease in the levels of serum CRP.
AN - rayyan-563559840
AU - Skaleric, E.
AU - Hropot Pleško, N.
AU - Skalerič, U.
DO - 10.1111/jcpe.13636
KW - C reactive protein
chlorhexidine
endogenous compound
adult
aged
bleeding on probing
clinical article
conference abstract
controlled study
disinfection
female
gene expression
human
human tissue
immunochemistry
male
mouth cavity
neck circumference
periodontitis
periodontium
protein blood level
protein expression
stone formation
tongue
ultrasound
wound
LA - English
PY - 2022
SN - 1600-051X
SP - 218
ST - The effect of full mouth disinfection on periodontal wound, periodontal
inflammatory burden and serum C-reactive protein level
TI - The effect of full mouth disinfection on periodontal wound, periodontal
inflammatory burden and serum C-reactive protein level
VL - 49
ID - 13214
ER -
TY - JOUR
AB - The effect of a triclosan-containing (0.3%) dental gel on inflammatory
mediators in gingival crevicular fluid (GCF) was evaluated in 14 healthy
adolescents undergoing orthodontic treatment with fixed appliances. A double-blind
randomized split-mouth study design was used with color-coded experimental and
placebo gels. The gel was self-applied for 5 min twice daily for 14 days in custom-
made soft plastic trays. Clinical data (visible plaque index (VPI) and gingival
bleeding index (GBI) and samples of GCF were collected at baseline and after 1, 2,
4, and 6 Weeks. The concentrations of prostaglandin I2 (PGI2 and interleukin-1β
(IL-1β) were determined by radioimmuno- and enzyme-linked immunosorbent assays,
respectively. No clinical effects of the gel applications regarding amount of
plaque or gingival bleeding were unveiled. Neither the experimental nor the placebo
gel applications caused any statistically significant alterations in the
inflammatory mediators, PGI2 and IL-1β, compared to baseline. In conclusion, the
present study did not reveal any beneficial effects of the triclosan-containing gel
regimen on mild gingivitis in adolescents with fixed orthodontic appliances.
AN - rayyan-563560879
AU - Sköld-Larsson, K.
AU - Yucel-Lindberg, T.
AU - Twetman, S.
AU - Modéer, T.
DO - 10.1080/00016350310003242
IS - 4
KW - interleukin 1beta
placebo
prostacyclin
triclosan
adolescent
adult
article
clinical article
clinical trial
controlled study
disease association
disease severity
dose response
female
gel
gingiva
gingiva bleeding
gingivitis
human
inflammation
male
mediator release
orthodontic device
radioimmunoassay
LA - English
PY - 2003
SN - 0001-6357
SP - 193-196
ST - Effect of a triclosan-containing dental gel on the levels of prostaglandin I2
and interleukin-1β in gingival crevicular fluid from adolescents with fixed
orthodontic appliances
TI - Effect of a triclosan-containing dental gel on the levels of prostaglandin I2
and interleukin-1β in gingival crevicular fluid from adolescents with fixed
orthodontic appliances
VL - 61
ID - 14253
ER -
TY - JOUR
AB - AIM: Based on the existing scientific literature, the effect of chlorhexidine
(CHX) dentifrice/gel as compared to a regular or placebo dentifrice/gel is
established in healthy adults on the primary outcome parameters of plaque and
gingivitis scores. As secondary parameter, tooth surface discoloration was
evaluated as a side effect. RESULTS: Independent screening of 389 unique titles and
abstracts resulted in 16 comparisons. Of these, nine evaluated CHX dentifrice (0.4-
1.0%) and 7 CHX gel (0.2-2.0%). It was not possible to perform a meta-analysis;
therefore, a descriptive analysis was carried out. Regarding plaque score
reduction, the majority of the experiments using a CHX dentifrice provided a
significant positive effect. All studies assessing gingival bleeding as parameter
for gingivitis observed a significant reduction in favour of CHX dentifrice over
placebo dentifrice. Tooth surface discoloration was more pronounced with CHX
dentifrice. The combined data concerning parameters of interest for CHX gel
compared with a placebo did not show a trend towards a beneficial effect on plaque
and bleeding scores. CONCLUSIONS: Within the limitations of this analysis, it may
be concluded that toothbrushing with a CHX gel does not provide conclusive
evidence. Brushing with a CHX dentifrice can be effective with regard to the
control of plaque and gingivitis. Tooth surface discoloration was observed as side
effect, which potentially can have a negative impact on patients' compliance.
MATERIALS AND METHODS: MEDLINE, EMBASE and Cochrane Central Register of Controlled
Trials were searched up to July 2013 to identify eligible studies. Included were
(randomized) controlled clinical trials, regarding self-performed brushing by
adults without periodontitis with a minimum duration of 4 weeks.
AN - rayyan-563560431
AU - Slot, D. E.
AU - Berchier, C. E.
AU - Addy, M.
AU - Van der Velden, U.
AU - Van der Weijden, G. A.
DO - 10.1111/idh.12050
IS - 1
KW - chlorhexidine
gel
toothpaste
chemically induced
classification
tooth plaque
gingivitis
human
meta analysis
periodontics
tooth discoloration
LA - English
PY - 2014
SN - 1601-5037
SP - 25-35
ST - The efficacy of chlorhexidine dentifrice or gel on plaque, clinical
parameters of gingival inflammation and tooth discoloration: a systematic review
T2 - Int J Dent Hyg
TI - The efficacy of chlorhexidine dentifrice or gel on plaque, clinical
parameters of gingival inflammation and tooth discoloration: a systematic review
VL - 12
ID - 13805
ER -
TY - CHAP
AN - rayyan-563562092
AU - Smart, G.
AU - Miraftab, M.
AU - Kennedy, J. F.
AU - Groocock, M. R.
DO - 10.1533/9781845694104.1.67
PY - 2005
SP - 67-72
ST - Chitosan: Crawling from crab shells to wound dressings
T2 - Medical Textiles and Biomaterials for Healthcare: Incorporating Proceedings
of MEDTEX03 International Conference and Exhibition on Healthcare and Medical
Textiles
TI - Chitosan: Crawling from crab shells to wound dressings
84902219099&doi=10.1533%2f9781845694104.1.67&partnerID=40&md5=ad3cbff8c8c9219f4bcfd
9242069c558
ID - 15466
ER -
TY - CPAPER
AB - Chitin is a naturally occurring polymeric material with a structure similar
to cellulose and was originally found to be present in fungi and later in the
skeletons of insects and shellfish. Chitin is insoluble in water but when modified
with boiling potassium hydroxide solution produces the derivative chitosan, which
is soluble in weak acids. Chitosan is biocompatible, biodegradable and non-toxic
with excellent antibacterial properties. These qualities make it suitable for use
in many medical applications. It is a versatile material, able to be used as
fibres, films, beads, gels and support matrices or blended with other materials.
Fibres and films are suitable for use in wound care whereas beads or microcapsules
are used as vehicles for drug delivery. Chitosan incorporated into a support matrix
for tissue engineering or bone repair increases the rate of cell regeneration. The
ability to form a hydrogel plus the biocompatibility and antibacterial properties
have been used to good effect in the area of periodontal surgery. Chitosan has
demonstrated hypocholesteric effects when used as a food supplement with an
improvement in the HDL-cholesterol/total cholesterol ratio. Chitosan products have
wide ranging uses throughout the pharmaceutical, dietary and water treatment
industries. This poster illustrates the processing route from chitin to chitosan
plus the varied application areas for chitosan products that can be found within
the medical field.
AN - rayyan-563562544
AU - Smart, G.
AU - Miraftab, M.
AU - Kennedy, J. F.
AU - Groocock, M. R.
PY - 2006
SP - 67-72
T2 - MEDICAL TEXTILES AND BIOMATERIALS FOR HEALTHCARE
TI - Chitosan: Crawling from crab shells to wound dressings
ID - 15918
ER -
TY - JOUR
AB - The delivery of therapeutic agents to, or via, the oral cavity is limited by
the efficient removal mechanisms that exist in this area. Lectins are proteins or
glycoproteins that bind to specific sugar residues, and can, therefore, interact
with the glycoconjugates present on cell surfaces or salivary mucins. Endogenous
lectins could also be used as points of attachment for carbohydrate-containing
delivery systems. This review considers the possibility of using lectins as
targeting agents within the oral cavity and reports on some of the limited number
of studies completed to date. As lectins are multifunctional molecules, the
possibility of using them as both targeting and therapeutic agents is considered.
Lectin-containing delivery systems are a potential innovation for targeted and
prolonged therapy within the oral cavity, but considerations such as toxicity and
cost will need to be addressed before their routine use becomes a reality. © 2003
Elsevier B.V. All rights reserved.
AN - rayyan-563560869
AU - Smart, J. D.
DO - 10.1016/j.addr.2003.10.016
IS - 4
endothelial leukocyte adhesion molecule 1
glycoconjugate
lectin
mucin
PADGEM protein
aphthous stomatitis
candidiasis
Corynebacterium
cost benefit analysis
cytotoxicity
drug cost
drug formulation
drug retention
drug specificity
drug targeting
epithelium cell
first pass effect
functional anatomy
gel
gingivitis
human
lamina propria
lectin binding
lectin binding site
lozenge
mouth carcinoma
mouth cavity
mouth flora
mouth mucosa
mouthwash
nonhuman
paste
periodontal disease
physiology
priority journal
protein analysis
protein binding
protein expression
protein structure
review
saliva
salivary gland
structure analysis
tablet
taste bud
tongue
tonsil
tooth
tooth disease
xerostomia
LA - English
PY - 2004
SN - 0169-409X
SP - 481-489
ST - Lectin-mediated drug delivery in the oral cavity
TI - Lectin-mediated drug delivery in the oral cavity
VL - 56
ID - 14243
ER -
TY - JOUR
AN - rayyan-563561958
AU - Smiley, C. J.
AU - Tracy, S. L.
AU - Abt, E.
AU - Michalowicz, B. S.
AU - John, M. T.
AU - Gunsolley, J.
AU - Cobb, C. M.
AU - Rossmann, J.
AU - Harrel, S. K.
AU - Forrest, J. L.
AU - Hujoel, P. P.
AU - Noraian, K. W.
AU - Greenwell, H.
AU - Frantsve-Hawley, J.
AU - Estrich, C.
AU - Hanson, N.
DO - 10.1016/j.adaj.2015.01.026
IS - 7
PY - 2015
SP - 525-535
ST - Evidence-based clinical practice guideline on the nonsurgical treatment of
chronic periodontitis by means of scaling and root planing with or without adjuncts
T2 - Journal of the American Dental Association
TI - Evidence-based clinical practice guideline on the nonsurgical treatment of
chronic periodontitis by means of scaling and root planing with or without adjuncts
84937469224&doi=10.1016%2fj.adaj.2015.01.026&partnerID=40&md5=d17f41f0cea7b133978c6
fdfc32b3eca
VL - 146
ID - 15332
ER -
TY - JOUR
AN - rayyan-563561916
AU - Smiley, C. J.
AU - Tracy, S. L.
AU - Abt, E.
AU - Michalowicz, B. S.
AU - John, M. T.
AU - Gunsolley, J.
AU - Cobb, C. M.
AU - Rossmann, J.
AU - Harrel, S. K.
AU - Forrest, J. L.
AU - Hujoel, P. P.
AU - Noraian, K. W.
AU - Greenwell, H.
AU - Frantsve-Hawley, J.
AU - Estrich, C.
AU - Hanson, N.
DO - 10.1016/j.adaj.2015.01.028
IS - 7
PY - 2015
SP - 508-524.e5
ST - Systematic review and meta-analysis on the nonsurgical treatment of chronic
periodontitis by means of scaling and root planing with or without adjuncts
T2 - Journal of the American Dental Association
TI - Systematic review and meta-analysis on the nonsurgical treatment of chronic
periodontitis by means of scaling and root planing with or without adjuncts
84937421671&doi=10.1016%2fj.adaj.2015.01.028&partnerID=40&md5=1c1deb8c57dcc725c78af
f62b69d7eec
VL - 146
ID - 15290
ER -
TY - JOUR
AB - BACKGROUND: Interleukin-6 (IL-6) concentrations vary substantially among
individuals. This study aimed to identify novel genetic markers to explain these
differences. METHODS: We sequenced a region 6-kb upstream of the IL6 [interleukin 6
(interferon, beta 2)] transcription start site in a search for functional variants
and detected 3 common variants: -6331T>C, -6101A>T, and -5617/-5616C/A>T/G. IL6-
6331T>C (C allele frequency, 0.20; 95% confidence interval, 0.16-0.24) showed
strong negative linkage disequilibrium with -174G>C (D′ = -0.97) and was studied
further in 309 individuals who underwent coronary artery bypass grafting. RESULTS:
Patients with the TT genotype had higher IL-6 concentrations 6 h after surgery than
those with the CC genotype (mean, 199.4 ng/L vs 114.9 ng/L; P = 0.02). A similar
association was seen in a cohort of 173 patients who underwent intensive
periodontal therapy: Individuals with the CC genotype had significantly lower IL-6
concentrations 24 h after therapy than TT patients (mean, 0.78 ng/L vs 5.00 ng/L; P
< 0.0001). A similar trend was observed in 203 healthy individuals from northern
Europe (1.29 ng/L for the TT genotype vs 0.89 ng/L for the CC genotype; P = 0.07).
Reporter assays that used a sequence flanking the -6331 single-nucleotide
polymorphism spliced upstream to the IL-6 minimal promoter driving luciferase gene
expression demonstrated a 1.3-fold increase in promoter activity (P<0.01) for
constructs containing -6331T. Electrophoretic mobility shift assays revealed
enhanced binding of transcription factor Oct-1 to the T allele. CONCLUSIONS: IL6 -
6331T is associated with increased IL-6 concentrations in an acute inflammatory
state via a mechanism involving binding of the Oct-1 transcription factor. This
finding may help resolve conflicting studies based on the IL6 -174G>C variant. ©
2008 American Association for Clinical Chemistry.
AN - rayyan-563560709
AU - Smith, A. J. P.
AU - D'Aiuto, F.
AU - Palmen, J.
AU - Cooper, J. A.
AU - Samuel, J.
AU - Thompson, S.
AU - Sanders, J.
AU - Donos, N.
AU - Nibali, L.
AU - Brull, D.
AU - Woo, P.
AU - Humphries, S. E.
DO - 10.1373/clinchem.2007.098608
IS - 5
KW - interleukin 6
luciferase
article
controlled study
coronary artery bypass graft
enzyme assay
gene frequency
gene identification
gene sequence
genetic analysis
genetic association
genetic linkage
genetic variability
genotype
human
LA - English
PY - 2008
SN - 0009-9147
SP - 841-850
ST - Association of serum interleukin-6 concentration with a functional IL6 -
6331T>C polymorphism
T2 - Clin. Chem.
TI - Association of serum interleukin-6 concentration with a functional IL6 -
6331T>C polymorphism
VL - 54
ID - 14083
ER -
TY - JOUR
AB - Introduction: Pulp revascularization may be considered a promising
alternative for necrotic immature teeth. Many studies have accomplished passive
decontamination associated with an antibiotic paste. To date, there is no report
evaluating calcium hydroxide associated with 2% chlorhexidine gel for
revascularization therapy. The aim of this case report was to describe a new
proposal for pulp revascularization with mechanical decontamination and intracanal
medication composed of calcium hydroxide and 2% chlorhexidine gel. Methods: The
patient, a 9-year-old girl, suffered an intrusion associated with pulp exposure
caused by an enamel-dentin fracture in her maxillary left central incisor. After
diagnosis, treatment consisted of revascularization therapy with gentle manual
instrumentation of the cervical and medium thirds of the root in addition to
intracanal medication with calcium hydroxide and 2% chlorftexidine gel for 21 days.
In the second session, a blood clot was stimulated up to the cervical third of the
root canal. Mineral trioxide aggregate (MTA; Angelus, Londrina, Parana, Brazil) was
used for cervical sealing of the canal. Coronal sealing was performed with
temporary filling material and composite resin. Results: During the follow-up
period, the root canal space showed a progressive decrease in width, mineralized
tissue deposition on root canal walls, and apical closure. A cone-beam computed
tomography scan taken at the 2-year follow-up confirmed these findings and did not
show complete root canal calcification. Conclusions: This new proposal for
revascularization therapy with 2% chlorhexidine gel may be used for the treatment
of necrotic immature root canals. (J Endod 2013;39:417-420)
AN - rayyan-563562548
AU - Soares, A. D.
AU - Lins, F. F.
AU - Nagata, J. Y.
AU - Gomes, Bpfd
AU - Zaia, A. A.
AU - de Souza-Filho, F. J.
DO - 10.1016/j.joen.2012.10.005
IS - 3
PY - 2013
SN - ["0099-2399", "1878-3554"]
SP - 417-420
ST - Pulp Revascularization after Root Canal Decontamination with Calcium
Hydroxide and 2% Chlorhexidine Gel
TI - Pulp Revascularization after Root Canal Decontamination with Calcium
Hydroxide and 2% Chlorhexidine Gel
VL - 39
Y2 - 3
ID - 15922
ER -
TY - JOUR
AB - Asiaticoside (AS), an active herbal compound isolated from Centella asiatica,
has the potential benefit in promoting type I collagen (COL I) synthesis and
osteogenic differentiation in human periodontal ligament cells (HPDLCs). However,
it has low aqueous solubility which may hamper the bioavailability. Thus, the aim
of this study was to develop thermoresponsive in situ gel containing
AS/cyclodextrin (CD) complexes. The non-encapsulated formulations consisted of
AS/hydroxypropyl beta-CD (HP beta CD) complexes and encapsulated formulations
containing AS loaded sulfobutylether beta-CD/chitosan nanoparticles (SBE beta CD/CS
NPs) were prepared. The appearance, pH and viscosity of all formulations were
within the acceptable range. All formulations formed relatively rapid sol-to-gel
transition when contacted with simulated salivary fluid at body temperature.
Compared to non-encapsulated formulations, in vitro gelation and rheological
studies of encapsulated formulations displayed gel formation that remained longer
with high mechanical strength. In vitro mucoadhesion and in vitro release studies
revealed that nanoencapsulated in situ gel had excellent mucoadhesive property and
could release AS in a sustained manner. These formulations exhibited no cytotoxic
effects to HPDCLs. The SBE beta CD/CS NPs containing low AS content could express
the COL I synthesis. Thus, nanoencapsulated platform could serve as a promising
carrier to deliver AS for periodontal tissue regeneration.
AN - rayyan-563562264
AU - Soe, Hmsh
AU - Luckanagul, J. A.
AU - Pavasant, P.
AU - Jansook, P.
DO - 10.1016/j.ijpharm.2020.119589
PY - 2020
SN - ["0378-5173", "1873-3476"]
ST - Development of in situ gel containing asiaticoside/cyclodextrin complexes.
Evaluation in culture human periodontal ligament cells (HPLDCs)
TI - Development of in situ gel containing asiaticoside/cyclodextrin complexes.
Evaluation in culture human periodontal ligament cells (HPLDCs)
VL - 586
Y2 - 8 y3 - 30
ID - 15638
ER -
TY - JOUR
AB - Background: The aim of this study was to evaluate the clinical and
microbiological effects of local application minocycline HCl 2% gel, used as an
adjunct to scaling and root planing (SRP) for treatment of chronic periodontitis
(CP). CP is an inflammation of periodontal tissue that is caused mainly by
bacterial infection, where periodontal destruction such as loss of attachment and
bone destruction occurred. Methods: A total of 81 subjects with moderate to severe
periodontitis whose baseline clinical attachment loss (CAL) was ≥4 mm were randomly
assigned to receive SRP alone (control group, N=39) or SRP followed by four times
of local application of minocycline HCl gel (Periocline) once a week (test group,
N=42). Pocket depth, CAL, and papilla bleeding index were examined at baseline, 21
days, 2, 3, and 6 months. Subgingival plaque samples were collected with sterile
curettes and were analyzed by real-time polymerase chain reaction for the presence
of three periodontal pathogens (Porphyromonas gingivalis [P.g.], Tannerella
forsythia [T.f.], and Treponema denticola [T.d.]) at baseline, 2, 3, and 6 months.
Results: The number of bacteria was reduced in both groups at 2 months after
baseline (SRP treatment). The changes (2–6 months) in T.d. and T.f. counts in the
test group were significantly lower than those in the control group. In the control
group, a significant regrowth of P.g., T.f., and T.d. was observed from 2 to 6
months and of P.g. and T.f. from 3 to 6 months. On the other hand, in the test
group, the number of the three bacteria did not significantly increase during the
6-month period. Conclusion: The results showed that local application of
minocycline, used as an adjunct to SRP, was effective for suppressing regrowth of
periodontal pathogens, suggesting its risk reduction of recurrent periodontal
pathogens in CP.
AN - rayyan-563560306
AU - Soeroso, Y.
AU - Akase, T.
AU - Sunarto, H.
AU - Kemal, Y.
AU - Salim, R.
AU - Octavia, M.
AU - Viandita, A.
AU - Setiawan, J.
AU - Bachtiar, B. M.
DO - 10.2147/TCRM.S130257
KW - minocycline
adjuvant therapy
adult
article
bacterial growth
bacterial load
controlled study
dental scaling
female
human
male
nonhuman
periodontium
risk reduction
root planing
Treponema denticola
periocline
LA - English
PY - 2017
SN - ["1178-203X", "1176-6336"]
SP - 307-314
ST - The risk reduction of recurrent periodontal pathogens of local application
minocycline HCL 2% gel, used as an adjunct to scaling and root planing for chronic
T2 - Ther. Clin. Risk Manage.
TI - The risk reduction of recurrent periodontal pathogens of local application
minocycline HCL 2% gel, used as an adjunct to scaling and root planing for chronic
VL - 13
ID - 13680
ER -
TY - JOUR
AB - Background Bacteria release outer membrane vesicles (OMV) which do contain
proteins, DNA and enzymes like peptidylarginine deiminase (PPAD) from gingivalis to
interact with bacteria and the host immune system. PPAD has been implicated in the
pathogenesis of rheumatoid arthritis (RA). The authors have examined were PPAD its
modified in the immune response which patients and controls do respond to
Porphyromonas gingivalis OMV (POMV) and PPAD. Methods PPAD was analysed in POMVs,
recombinantly expressed and separated by 2-dimensional sodium dodecyl sulfate
polyacrylamide gel electrophoresis (2D SDS-PAGE). PPAD was analysed my mass
spectrometry (MS). Modifications and the immune reactivity was tested with sera in
ELISA and immunobloting. Results The authors have analysed the POMV reactivity and
found significant reactions of RA patients and controls to the PPAD and other
proteins of the POMV. The authors could show that PPAD in OMVs is cleaved rendering
it into an active enzyme. POMVs can interact with histones to protect bacteria from
antibacterial response of histones. Moreover the anti H1 histone antibody response
of systemic lupus erythematosus (SLE) sera can be blocked by POMVs. H1 histone
citrullinated with rabbit PAD was positive with anticitrullinated peptide
antibodies (ACPA) positive and negative RA and SLE sera. Interestingly PPAD
incubated with H1 histone gave no additional reactivity with RA sera and controls.
Out of 69 early RA sera, and 23 periodontitis sera (PD), 10 SLE and 10 healthy
controls 100% of the early RA and PD sera, 70% of the SLE and 90% of the healthy
control sera were reactive with the recombinant PPAD. This immune reactivity
correlated with the positivity to P gingivalis lipopolysaccharides ELISA. Specific
response to the citrullinated form of PPAD could be detected with affinity purified
ACPA antibodies from different citrullinated peptides only with RA sera. The human
affintity purified patient ACPA antibodies reacted specifically with the 2D SDS-
PAGE separated autocitrullinated form of PPAD. Autocitrullination of PPAD was
detected by MS, with human anti cit-fibrinogen antibodies and the antimodified
citrulline kit. PPAD citrullination activity was tested with different peptide
sequences containing arginine. Sequence and pH dependent cit-reactions could be
detected. Conclusion PPAD autocitrullination and sequence and pH dependent
intramolecular citrullination can be detected using different methods. Anti OMV and
PPAD antibody reaction is commonly found in RA, SLE and healthy controls. ACPA
specific binding with the autocitrullinated form of PPAD can be only detected in RA
sera.
AN - rayyan-563560558
AU - Sohn, M.
AU - Marklein, B.
AU - Burmester, G. R.
AU - Skriner, K.
DO - 10.1136/annrheumdis-2011-201232.5
KW - protein arginine deiminase
histone H1
antibody
enzyme
protein
histone
arginine
citrulline
fibrinogen
peptide
lipopolysaccharide
peptide antibody
histone antibody
antiinfective agent
DNA
membrane vesicle
infection
model
workshop
rheumatology
outer membrane
serum
human
bacterium
patient
immunoreactivity
pH
amino acid sequence
pathogenesis
periodontitis
mass spectrometry
immune system
Leporidae
immune response
antibody response
antigen antibody reaction
LA - English
PY - 2012
SN - 0003-4967
SP - A27-A28
ST - Outer membrane vesicles containing autocitrullinated peptidylarginine
deiminase from porphyromonas gingivalis part of an infection model in RA?
T2 - Ann. Rheum. Dis.
TI - Outer membrane vesicles containing autocitrullinated peptidylarginine
deiminase from porphyromonas gingivalis part of an infection model in RA?
VL - 71
ID - 13932
ER -
TY - JOUR
AB - Background Bacteria release outer membrane vesicles (OMV) which do contain
proteins, DNA and enzymes like Peptidylarginine Deiminase from Porphyromonas
gingivalis (PPAD) to interact with bacteria and the host immune system. PPAD has
been implicated in the pathogenesis of rheumatoid arthritis (RA). Objectives We
have examined were PPAD its modified in the immune response which patients and
controls do respond to Porphyromonas gingivalis outer membrane vesicles (POMV) and
PPAD. Methods PPAD was analysed in POMVs, recombinantly expressed and separated by
2D SDS-PAGE. PPad was analysed my mass spectrometry (MS). Modifications and the
immune reactivity was tested with sera in ELISA and immunobloting. Results We have
analysed the POMV reactivity and found significant reactions of RA patients and
controls to the PPAD and other proteins of the POMV. We could show that PPAD in
OMVs is cleaved rendering it into an active enzyme. POMVs can interact with
histones to protect bacteria from antibacterial response of histones. Moreover the
anti H1 histone antibody response of SLE sera can be blocked by POMVs. H1 histone
citrullinated with rabbit PAD was positive with ACPA positive and negative RA and
SLE sera. Out of 69 early RA sera, and 23 periodontitis sera (PD), 10 SLE and 10
healthy controls 100% of the early RA and PD sera, 70% of the SLE and 90% of the
healthy control sera were reactive with the recombinant PPAD. This immune
reactivity correlated with the positivity to P.g LPS ELISA. Specific response to
the citrullinated form of PPAD could be detected with affinity purified ACPA
antibodies from different citrullinated peptides only with RA sera. The human
affintity purified patient ACPA (anti-citrullinated protein antibody) antibodies
reacted specifically with the 2D SDS-PAGE separated autocitrullinated form of PPAD.
Autocitrullination of PPAD was detected by MS, with human anti Cit-Fibrinogen
antibodies and the anti-modified citrulline kit. PPAD citrullination activity was
tested with different peptide sequences containing arginine. Sequence and pH
dependent cit-reactions could be detected. Conclusions PPAD autocitrullination and
sequence and pH dependent intramolecular citrullination can be detected using
different methods. Anti OMV and PPAD antibody reaction is commonly found in RA, SLE
and healthy controls. ACPA specific binding with the autocitrullinated form of PPAD
can be only detected in RA sera. The autocitrullinated bacterial protein PPAD might
be part of an infection model for the generation of RA specific ACPAs.
AN - rayyan-563560482
AU - Sohn, M.
AU - Marklein, B.
AU - Burmester, G. R.
AU - Skriner, K.
DO - 10.1136/annrheumdis-2012-eular.167
KW - protein arginine deiminase
antibody
protein
enzyme
histone
histone H1
antiinfective agent
arginine
citrulline
fibrinogen
protein antibody
peptide
bacterial protein
histone antibody
DNA
infection
model
rheumatology
rheumatic disease
serum
human
patient
bacterium
membrane vesicle
outer membrane
immunoreactivity
pH
antigen antibody reaction
amino acid sequence
mass spectrometry
pathogenesis
immune response
periodontitis
Leporidae
antibody response
immune system
LA - English
PY - 2013
SN - 0003-4967
ST - Autocitrullinated peptidylarginine deiminase from porphyromonas gingivalis
part of an infection model in RA?
T2 - Ann. Rheum. Dis.
TI - Autocitrullinated peptidylarginine deiminase from porphyromonas gingivalis
part of an infection model in RA?
VL - 71
ID - 13856
ER -
TY - JOUR
AB - Scaling and root planing represent the gold standard in the treatment of
periodontal dis-ease, but these therapeutic methods cannot eliminate the remaining
periodontopathogenic bacteria in cement, tubules, and periodontal soft tissue.
Thus, a number of additional therapeutic means have been adopted, including local
and systemic antibiotic therapy, as well as the use of photody-namic therapy
techniques. Recently, special attention has been paid to potential phytotherapeutic
means in the treatment of periodontal disease. In this review, we aim to present
the effects generated by the extract of Curcuma longa, the various forms of
application of turmeric as an additional therapeutic means, as well as the aspects
related to its biotolerance.
AN - rayyan-563559855
AU - Solomon, S. M.
AU - Stafie, C. S.
AU - Sufaru, I. G.
AU - Teslaru, S.
AU - Ghiciuc, C. M.
AU - Petrariu, F. D.
AU - Tanculescu, O.
IS - 5
KW - aryldialkylphosphatase 1
catalase
curcumin
cyclooxygenase 2
enzyme
gel
glutamate cysteine ligase
heme oxygenase 1
interleukin 10
interleukin 1beta
interleukin 6
lipoxygenase 2
macrophage inflammatory protein 1
macrophage inflammatory protein 1 alpha
quinone oxidoreductase 1
reduced nicotinamide adenine dinucleotide phosphate
turmeric
unclassified drug
allergy
biotolerance
Curcuma longa
dental procedure
drug therapy
drug tolerance
human
immunology
local periodontal therapy
nonhuman
oral irrigation
oral rinsing
periodontal adjunctive treatment
periodontics
review
LA - English
PY - 2022
SN - 1999-4923
ST - Curcumin as a Natural Approach of Periodontal Adjunctive Treatment and Its
Immunological Implications: A Narrative Review
T2 - Pharmaceutics
TI - Curcumin as a Natural Approach of Periodontal Adjunctive Treatment and Its
Immunological Implications: A Narrative Review
VL - 14
ID - 13229
ER -
TY - JOUR
AB - Development of novel and effective drug delivery systems for controlled
release of bioactive molecules is of critical importance in the field of
regenerative medicine. Here, oppositely charged gelatin nanospheres are
incorporated into silk fibroin nanofibers through a colloidal electrospinning
technique. A novel fibrous nano-in-nano drug delivery system is fabricated without
the use of any organic solvent. The distribution of fluorescently labeled gelatin A
and B nanospheres inside the nanofibers can be fine-tuned by simple adjustment of
the weight ratio between the nanospheres and the relative feeding rate of core and
shell solutions containing nanospheres by using single and coaxial nozzle
electrospinning, respectively. Incorporation of vancomycin-loaded gelatin B
nanospheres into the silk fibroin nanofibrous membranes results in a more sustained
release of vancomycin, compared to the gelatin nanospheres free membranes. In
addition, these membranes exhibit excellent and prolonged antibacterial effects
against Staphylococcus aureus. Moreover, these membranes support the attachment,
spreading, and proliferation of periodontal ligament cells. These results suggest
that the beneficial properties of gelatin nanospheres can be exploited to improve
the biological functionality of electrospun nanofibrous silk fibroin membranes.
AN - rayyan-563562594
AU - Song, J. K.
AU - Klymov, A.
AU - Shao, J. L.
AU - Zhang, Y.
AU - Ji, W.
AU - Kolwijck, E.
AU - Jansen, J. A.
AU - Leeuwenburgh, S. C. G.
AU - Yang, F.
DO - 10.1002/adhm.201700014
IS - 14
PY - 2017
SN - ["2192-2640", "2192-2659"]
ST - Electrospun Nanofibrous Silk Fibroin Membranes Containing Gelatin Nanospheres
for Controlled Delivery of Biomolecules
T2 - ADVANCED HEALTHCARE MATERIALS
TI - Electrospun Nanofibrous Silk Fibroin Membranes Containing Gelatin Nanospheres
for Controlled Delivery of Biomolecules
VL - 6
Y2 - 7 y3 - 19
ID - 15968
ER -
TY - JOUR
AN - rayyan-563561531
AU - Sonkusle, S.
AU - Pattanashetti, J. I.
AU - Kalburgi, N. B.
AU - Singh, V.
AU - Patil, K. A.
DO - 10.5005/jp-journals-10015-2125
IS - 6
PY - 2022
SP - 600-605
ST - Formulation and Evaluation of Antimicrobial Activity of Boswellia serrata
Roxb. Gel against Periodontal Pathogens: An In Vitro Study
TI - Formulation and Evaluation of Antimicrobial Activity of Boswellia serrata
Roxb. Gel against Periodontal Pathogens: An In Vitro Study
85137046941&doi=10.5005%2fjp-journals-10015-
2125&partnerID=40&md5=ecf64d636e99c3fa7d7f71efec6fb2d1
VL - 13
ID - 14905
ER -
TY - JOUR
AB - INTRODUCTION: Periodontitis is an inflammatory disease of microbial origin.
Local drug delivery agents help reduce subgingival microflora. Achyranthes aspera
is a medicinal herb with antimicrobial, antioxidant, anti-inflammatory, and wound-
healing properties. MATERIALS AND METHODS: A split-mouth study was conducted, in
which 60 sites were included. Clinical parameters included measurements of probing
depth (PD), gingival index, and clinical attachment level (CAL). Gingival
crevicular fluid (GCF) samples were collected, followed by microbiological analysis
of Porphyromonas Gingivalis. Clinical and microbiological parameters were recorded
at baseline and after 3 months. Statistical analysis was done using the Statistical
Package of Social Science (SPSS Version 22; Chicago Inc., USA). RESULT: At 3
months, Group A resulted in greater mean reductions in clinical parameters: PD
(3.77) as compared to Group B (5.23), and also greater mean CAL gain (3.18) in
group A as compared to Group B (5.16). Group A also showed a significant reduction
in the number of sites harboring periodontopathogens as compared to Group B.
CONCLUSION: A. aspera gel can be used as a nonsurgical local drug delivery agent in
patients with chronic periodontitis as an effective adjunct to SRP.
AN - rayyan-563561339
AU - Soorgani, N. R.
AU - Khashu, H.
AU - Agrawal, R.
AU - Ninan, R. K.
AU - Peter, S.
AU - Mukka, N.
DO - 10.4103/jpbs.jpbs_656_22
J2 - J Pharm Bioallied Sci
LA - eng
N1 - Department of Periodontics, Mansarovar Dental College, Bhopal, Madhya
Pradesh, India.; Department of Periodontics, Mansarovar Dental College, Bhopal,
Madhya Pradesh, India.; Department of Periodontics, Mansarovar Dental College,
Bhopal, Madhya Pradesh, India.; Department of Periodontics, Mansarovar Dental
College, Bhopal, Madhya Pradesh, India.; Department of Periodontics, Mansarovar
Dental College, Bhopal, Madhya Pradesh, India.; Department of Periodontics,
Mansarovar Dental College, Bhopal, Madhya Pradesh, India.
PY - 2023
SN - 0976-4879 (Print)
SP - S693-S697
ST - Clinical Effects of Subgingivally Delivered Achyranthes Aspera Gel in Chronic
Periodontitis: A Clinical and Microbiological Study
T2 - Journal of pharmacy & bioallied sciences
TI - Clinical Effects of Subgingivally Delivered Achyranthes Aspera Gel in Chronic
Periodontitis: A Clinical and Microbiological Study
VL - 15
Y2 - 7
ID - 14713
ER -
TY - JOUR
AB - Introduction: Periodontitis is an inflammatory disease of microbial origin.
Local drug delivery agents help reduce subgingival microflora. Achyranthes aspera
is a medicinal herb with antimicrobial, antioxidant, anti-inflammatory, and wound-
healing properties. Materials and Methods: A split-mouth study was conducted, in
which 60 sites were included. Clinical parameters included measurements of probing
depth (PD), gingival index, and clinical attachment level (CAL). Gingival
crevicular fluid (GCF) samples were collected, followed by microbiological analysis
of Porphyromonas Gingivalis. Clinical and microbiological parameters were recorded
at baseline and after 3 months. Statistical analysis was done using the Statistical
Package of Social Science (SPSS Version 22; Chicago Inc., USA). Result: At 3
months, Group A resulted in greater mean reductions in clinical parameters: PD
(3.77) as compared to Group B (5.23), and also greater mean CAL gain (3.18) in
group A as compared to Group B (5.16). Group A also showed a significant reduction
in the number of sites harboring periodontopathogens as compared to Group B.
Conclusion: A. aspera gel can be used as a nonsurgical local drug delivery agent in
patients with chronic periodontitis as an effective adjunct to SRP.
AN - rayyan-563559698
AU - Soorgani, N.
AU - Khashu, H.
AU - Agrawal, R.
AU - Ninan, R.
AU - Peter, S.
AU - Mukka, N.
DO - 10.4103/jpbs.jpbs_656_22
IS - 5
Achyranthes aspera
adult
article
controlled study
drug efficacy
gingival index
gingivitis
human
Illinois
informed consent
nonhuman
plaque index
LA - English
PY - 2023
SN - 0975-7406
SP - S693-S697
ST - Clinical effects of subgingivally delivered achyranthes aspera gel in chronic
periodontitis: A clinical and microbiological study
TI - Clinical effects of subgingivally delivered achyranthes aspera gel in chronic
periodontitis: A clinical and microbiological study
VL - 15
ID - 13072
ER -
TY - JOUR
AB - Substances that aid periodontal regeneration rely on accurate dissemination
of active agents to their targets comprising connective tissue and bone. Healing is
enhanced by incorporating a carrier agent and a time-release microshape containing
the active agent for sustained release and improved uptake at the site of delivery.
Chemotherapeutic agents range from antimicrobial, anti-inflamatory and tissue
regenerative agents such as platelet rich plasma, enamel matrix proteins, bioactive
glass, soy bean based bone fillers, calcium phosphate and brushite cements. Cell
recognition of tissue regenerative agents within a vehicular microcapsule for local
delivery aid capture of relevant cells at the required site, enhancing its actions
and sustenance. Gene based therapies for tissue regeneration promote expression of
specific proteins which lead to a steady supply of targeted stimulatory agents over
stipulated periods. Techniques of tissue engineering and gene therapy are combined
to enhance selective protein, expression and expansion of specific cell populations
on biodegradable scaffolds acting as carriers for dispensing the required agents.
These concepts demonstrate the relevance of optimal targeting and host response
which can enhance or detract from the outcome. Future work would aim to provide
more consistent results with greater accuracy in targeting and optimal dosing of
tissue-active agents. This review also addresses recent patents related to the
field. © 2008 Bentham Science Publishers Ltd.
AN - rayyan-563560728
AU - Soory, M.
DO - 10.2174/187221408783421318
IS - 1
KW - adenovirus vector
antiinfective agent
biomaterial
calcium phosphate
calcium phosphate dibasic
cellulose
cephalosporin
collagen
cortisone
flurbiprofen
glass
glycosaminoglycan
hyaluronic acid
indometacin
matrix protein
microsphere
penicillin G
polycaprolactone
polycarbonate
polyglactin
polylactide
polystyrene
polysulfone
polyurethan
tetracycline
unindexed drug
biodegradability
bone regeneration
cell population
dentistry
enamel
gene therapy
genetic engineering
genetic manipulation
human
hydrogel
immune response
medical research
microcapsule
periodontal disease
periodontic device
periodontics
priority journal
protein expression
review
soybean
stem cell transplantation
tissue regeneration
treatment outcome
tumor xenograft
viral gene delivery system
wound healing
LA - English
PY - 2008
SN - 1872-2148
SP - 35-44
ST - Periodontal regenerative materials and their applications: Goodness of fit?
T2 - Recent Pat. Endocr. Metab. Immune Drug Discov.
TI - Periodontal regenerative materials and their applications: Goodness of fit?
VL - 2
ID - 14102
ER -
TY - JOUR
AB - This review addresses the relevance of the consequences of dyslipidaemia
amongst patients with diabetes mellitus, cardiovascular and periodontal diseases.
Significant presentation of periodontal disease amongst poorly controlled diabetics
with cardiovascular complications is an important area for a coordinated
therapeutic approach. The pro-inflammatory cycle of events initiated by plaque
biofilm generates a similar sequence of events that leads to destruction of the
supporting structures of the periodontium. The features of metabolic syndrome and
type 2 diabetes mellitus in periodontal patients constitute risk factors for
cardiovascular disease with common risk markers such as IL-6, TNF-α, C-reactive
protein and low density lipoprotein; the inflammatory burden imposed by periodontal
disease contributes to endothelial dysfunction common to both diabetes mellitus and
cardiovascular disease. It is relevant that management of periodontal disease leads
to significant reduction in pro-inflammatory cytokines and acute phase proteins
associated with endothelial dysfunction and cardiovascular pathology. In addition
to reducing the inflammatory burden simultaneous control of metabolic factors
affecting lipid metabolism appears to be significant for optimal therapeutic
benefit. The potential contribution of periodontal disease to mortality and
morbidity arising from systemic diseases warrants a stringent approach to its
management. This article includes an appraisal of patents and patent applications
that explores therapeutic strategy for dyslipidaemia, cardiovascular disease and
diabetes mellitus in periodontal patients. © 2009 Bentham Science Publishers Ltd.
AN - rayyan-563560658
AU - Soory, M.
DO - 10.2174/187221409789104700
IS - 3
KW - 3 hydroxy 3 methylglutaryl coenzyme A
aminothiol
antioxidant
atorvastatin
doxycycline
flavonoid
interleukin 1beta
lactoferrin
lipopolysaccharide
meloxicam
metformin
methylcellulose
metronidazole
minocycline
nicotinic acid
pycnogenol
pyruvic acid
simvastatin
tocopherol
toll like receptor
ubidecarenone
antibody titer
atheroma
atherosclerosis
bacterial infection
bacterial strain
bone defect
cardiovascular risk
comorbidity
dental patient
diabetes mellitus
drug formulation
drug potentiation
drug targeting
dyslipidemia
endotoxemia
gel
human
hyperlipidemia
immunomodulation
inflammation
innate immunity
insulin resistance
low drug dose
macrophage
metabolic regulation
metabolic syndrome X
neuroprotection
ossification
osteolysis
oxidative stress
pathogenesis
periodontitis
primary prevention
priority journal
review
risk reduction
secondary prevention
LA - English
PY - 2009
SN - 1872-2148
SP - 214-224
ST - Relevance of dyslipidaemia and its consequences in periodontal patients with
co-existing cardiovascular disease and diabetes mellitus: Therapeutic targets
T2 - Recent Pat. Endocr. Metab. Immune Drug Discov.
TI - Relevance of dyslipidaemia and its consequences in periodontal patients with
co-existing cardiovascular disease and diabetes mellitus: Therapeutic targets
VL - 3
ID - 14032
ER -
TY - JOUR
AB - Background: The aim of our study was to evaluate the effects of a hyaluronic
acid (HA) gel at 45 days on the microbiome of implants with peri-implantitis with
at least 1 year of loading. Methods: A randomized controlled trial was conducted in
peri-implantitis patients. Swabs containing the samples were collected both at
baseline and after 45 days of treatment. 16S rRNA sequencing techniques were used
to investigate the effect of HA gel on the subgingival microbiome. Results: One
hundred and eight samples of 54 patients were analyzed at baseline and after
follow-up at 45 days. Three strata with different microbial composition were
obtained in the samples at baseline, representing three main microbial consortia
associated with peri-implantitis. Stratum 1 did not show any difference for any
variable after treatment with HA, whereas in stratum 2, Streptococcus, Veillonella,
Rothia, and Granulicatella did decrease (P < 0.05). Similarly, Prevotella and
Campylobacter (P < 0.05) decreased in stratum 3 after treatment with HA. Microbial
diversity was found to be decreased in stratum 3 (P < 0.05) after treatment with HA
compared with the control group, in which an increase was found (P < 0.05).
Conclusions: HA reduced the relative abundance of peri-implantitis-related
microorganisms, especially the early colonizing bacteria, suggesting a specific
action during the first stages in the development of the disease. HA did not alter
relative abundances of non-oral genera. The use of HA in advanced stages of peri-
implantitis resulted in a decrease in microbial alpha diversity, suggesting a
protective action of the peri-implant site against bacteria colonization.
AN - rayyan-563560119
AU - Soriano-Lerma, A.
AU - Magán-Fernández, A.
AU - Gijón, J.
AU - Sánchez-Fernández, E.
AU - Soriano, M.
AU - García-Salcedo, J. A.
AU - Mesa, F.
DO - 10.1002/JPER.19-0184
IS - 6
KW - tooth implant
hyaluronic acid
RNA 16S
adult
aged
antifungal activity
article
bacterial count
bioinformatics
controlled study
DNA extraction
DNA isolation
female
gene amplification
gene expression
human
immune response
intestine flora
male
metagenomics
microbial community
microbial consortium
microbial diversity
microbiome
microflora
mouth hygiene
osteolysis
periimplantitis
plaque index
RNA sequencing
short course therapy
Streptococcus
tooth brushing
LA - English
PY - 2020
SN - 0022-3492
SP - 734-745
ST - Short-term effects of hyaluronic acid on the subgingival microbiome in peri-
implantitis: A randomized controlled clinical trial
TI - Short-term effects of hyaluronic acid on the subgingival microbiome in peri-
implantitis: A randomized controlled clinical trial
VL - 91
ID - 13493
ER -
TY - JOUR
AB - This article reviews the current status of controlled local delivery of
antibacterial agents in the treatment of periodontitis. The principle of local
intrapocket delivery of antibacterial agents and their delivery are discussed. The
dosage forms include fibers, film/slabs, and injectable systems, some of which are
degradable, while others are not and need to be removed at the termination of the
treatment. The antibacterial agents used cover a range of antibiotics as well as
antiseptics, and the composition of the delivery systems, their reported use, and
the clinical results are summarized. The use of these systems in clinical practice
is relatively recent, and therefore their application and integration into the
dental office are not yet clearly defined. Clinical applications that have been
tested are critically reviewed, and clinical situations in which controlled
delivery of antibacterial agents may prove to be clinically useful are suggested
for scientific evaluation.
AN - rayyan-563562301
AU - Soskolne, W. A.
DO - 10.1177/10454411970080020501
IS - 2
PY - 1997
SN - 1045-4411
SP - 164-174
ST - Subgingival delivery of therapeutic agents in the treatment of periodontal
diseases
T2 - CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE
TI - Subgingival delivery of therapeutic agents in the treatment of periodontal
diseases
VL - 8
Y2 - 5
ID - 15675
ER -
TY - JOUR
AB - Background: This clinical study assessed the effects of topically applied tea
tree oil (TTO)-containing gel on dental plaque and chronic gingivitis. Methods:
This was a double-blind, longitudinal, non-crossover study in 49 medically fit non-
smokers (24 males and 25 females) aged 18-60 years with severe chronic gingivitis.
Subjects were randomly assigned to three groups and given either TTO-gel (2.5 per
cent), chlorhexidine (CHX) gel (0.2 per cent), or a placebo gel to apply with a
toothbrush twice daily. Treatment effects were assessed using the Gingival Index
(GI), Papillary Bleeding Index (PBI) and plaque staining score (PSS) at four and
eight weeks. Results: No adverse reactions to any of the gels were reported. The
data were separated into subsets by tooth (anterior and posterior) and tooth
surface (buccal and lingual). The TTO group had significant reduction in PBI and GI
scores. However, TTO did not reduce plaque scores, which tended to increase over
the latter weeks of the study period. Conclusion: Although further studies are
required, the anti-inflammatory properties of TTO-containing gel applied topically
to inflamed gingival tissues may prove to be a useful non-toxic adjunct to
chemotherapeutic periodontal therapy.
AN - rayyan-563560864
AU - Soukoulis, S.
AU - Hirsch, R.
DO - 10.1111/j.1834-7819.2004.tb00054.x
IS - 2
KW - chlorhexidine
placebo
tea tree oil
adult
article
clinical article
controlled study
dental procedure
drug effect
drug safety
female
gel
gingivitis
human
male
scoring system
staining
tooth brushing
tooth plaque
LA - English
PY - 2004
SN - 0045-0421
SP - 78-83
ST - The effects of a tea tree oil-containing gel on plaque and chronic gingivitis
T2 - Aust. Dent. J.
TI - The effects of a tea tree oil-containing gel on plaque and chronic gingivitis
VL - 49
ID - 14238
ER -
TY - JOUR
AB - Local drug delivery of antimicrobics by sustained release delivery systems
can be used to treat periodontal disease. Advantages of these systems may include
biodegradation of the system, maintaining high levels of antibiotic in the gingival
crevicular fluid (GCF for a sustained period of time and ease of use with high
patient acceptance. This review will identify human in vivo clinical and
microbiological studies. Sustained release formulations, application methods,
clinical results and microbiological effects are discussed. (C) 1998 Elsevier
Science B.V. All rights reserved.
AN - rayyan-563562312
AU - Southard, G. L.
AU - Godowski, K. C.
DO - 10.1016/S0924-8579(98)00004-1
IS - 4
PY - 1998
SN - ["0924-8579", "1872-7913"]
SP - 239-253
ST - Subgingival controlled release of antimicrobial agents in the treatment of
periodontal disease
T2 - INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
TI - Subgingival controlled release of antimicrobial agents in the treatment of
periodontal disease
VL - 9
Y2 - 2
ID - 15686
ER -
TY - JOUR
AB - Aim: Curcumin (CUR) has been used clinically in several studies as a
subgingival irrigant or as a photoantimicrobial in combination with a blue light-
emitting diode (LED) in antimicrobial photodynamic therapy (aPDT) adjuvant to
scaling and root planing (SRP). The aim of this study was to assess the
effectiveness of CUR as an irrigant or as a photoantimicrobial in conjunction with
the blue LED in aPDT adjuvant to SRP, compared to SRP as conventional mechanical
treatment. Materials and methods: Fifteen randomized controlled trials (RCT) were
included in a qualitative analysis after researching the databases: PubMed /
MEDLINE, SCOPUS, EMBASE, Cochrane Central, Web of Science and Scielo. Manual
searches were also performed. Five studies were submitted to quantitative analysis,
evaluating periodontal clinical parameters such as probing depth (PD) and clinical
attachment level (CAL). Results: The obtained results have shown clinical benefits
in PD reduction and CAL gains at 3 months with the use of CUR as adjuvant therapy
to SRP, both as an irrigant or photoantimicrobial, in comparison with SRP
monotherapy. Conclusion: Currently, there is evidence that treatment with CUR
applied as irrigant or in conjunction with the blue LED as aPDT presents superior
clinical results in the short term, for clinical periodontics parameters like as PD
reduction and CAL gain, when compared to SRP monotherapy in the non-surgical
treatment of periodontitis. However, these results cannot be proven in the long
term.
AN - rayyan-563562340
AU - Souza, E. Q. M.
AU - da Rocha, T. E.
AU - Toro, L. F.
AU - Guiati, I. Z.
AU - Freire, J. D. A.
AU - Ervolino, E.
AU - Brandini, D. A.
AU - Garcia, V. G.
AU - Theodoro, L. H.
DO - 10.1016/j.pdpdt.2021.102265
PY - 2021
SN - ["1572-1000", "1873-1597"]
ST - Adjuvant effects of curcumin as a photoantimicrobial or irrigant in the non-
surgical treatment of periodontitis: Systematic review and meta-analysis
TI - Adjuvant effects of curcumin as a photoantimicrobial or irrigant in the non-
VL - 34
Y2 - 6
ID - 15714
ER -
TY - JOUR
AB - Aim: Curcumin (CUR) has been used clinically in several studies as a
subgingival irrigant or as a photoantimicrobial in combination with a blue light-
emitting diode (LED) in antimicrobial photodynamic therapy (aPDT) adjuvant to
scaling and root planing (SRP). The aim of this study was to assess the
effectiveness of CUR as an irrigant or as a photoantimicrobial in conjunction with
the blue LED in aPDT adjuvant to SRP, compared to SRP as conventional mechanical
treatment. Materials and methods: Fifteen randomized controlled trials (RCT) were
included in a qualitative analysis after researching the databases: PubMed /
MEDLINE, SCOPUS, EMBASE, Cochrane Central, Web of Science and Scielo. Manual
searches were also performed. Five studies were submitted to quantitative analysis,
evaluating periodontal clinical parameters such as probing depth (PD) and clinical
attachment level (CAL). Results: The obtained results have shown clinical benefits
in PD reduction and CAL gains at 3 months with the use of CUR as adjuvant therapy
to SRP, both as an irrigant or photoantimicrobial, in comparison with SRP
monotherapy. Conclusion: Currently, there is evidence that treatment with CUR
applied as irrigant or in conjunction with the blue LED as aPDT presents superior
clinical results in the short term, for clinical periodontics parameters like as PD
reduction and CAL gain, when compared to SRP monotherapy in the non-surgical
treatment of periodontitis. However, these results cannot be proven in the long
term.
AN - rayyan-563559988
AU - Souza, E. Q. M.
AU - da Rocha, T. E.
AU - Toro, L. F.
AU - Guiati, I. Z.
AU - Freire, J. D. O. A.
AU - Ervolino, E.
AU - Brandini, D. A.
AU - Garcia, V. G.
DO - 10.1016/j.pdpdt.2021.102265
KW - curette
Satelec P5
ultrasonic scaler
cervitec
chlorhexidine
Curcuma longa extract
curcumin
gel
poloxamer
adjuvant therapy
adult
aged
clinical assessment
dental scaling
drug efficacy
Forsythia
gingival index
gingivitis
human
irradiation
meta analysis
monotherapy
periodontal pocket
periodontitis
plaque index
priority journal
review
root planing
systematic review
LA - English
PY - 2021
SN - ["1873-1597", "1572-1000"]
ST - Adjuvant effects of curcumin as a photoantimicrobial or irrigant in the non-
TI - Adjuvant effects of curcumin as a photoantimicrobial or irrigant in the non-
VL - 34
ID - 13362
ER -
TY - JOUR
AB - Objective: To update and evaluate the existing scientific evidence in the
efficacy of metronidazole as an adjunct as well as an alternative to subgingival
debridement/instrumentation. Methods: Electronic data bases such as Pubmed,
Cochrane Central Register of Controlled Trials and Embase were searched for
randomized clinical trials (RCTs) that compared the scaling and root planing (SRP)
with adjunctive and alternative metronidazole. Results: This review included
twenty-six papers which evaluated the clinical indices such as probing pocket depth
(PPD), clinical attachment level (CAL), bleeding on probing (BOP) and/or plaque
index (PlI). A pair of papers reported the same data at two different papers. Four
papers had two test groups. Seven adjunctive studies which used metronidazole in
the gel formulation showed statistical significance in reduction of PPD whereas
only two studies were able to show a statistical significant gain in CAL. Only one
study revealed a significant reduction in BOP. Metronidazole monotherapy has shown
a similar reduction in PPD and improvement in CAL to the same extent of SRP.
Conclusions: Taken together it can be delineated that metronidazole may be
indicated in patients who have localized persistent and recurrent lesions as an
adjunct. However, more RCTs with strict methodological criteria are necessary to
come to a firm conclusion.
AN - rayyan-563559937
AU - Soysa, N. S.
AU - Waidyarathne, H.
AU - Ranaweera, M.
AU - Alles, C. N. R. A.
DO - 10.1016/j.dentre.2021.100006
IS - 1
KW - metronidazole
adult
bleeding on probing
Cochrane Library
debridement
Embase
female
human
male
Medline
monotherapy
periodontal disease
plaque index
priority journal
review
root planing
systematic review
LA - English
PY - 2021
SN - 2772-5596
ST - Clinical efficacy of local application of sustained-release metronidazole in
periodontal therapy
T2 - Dent. Rev.
TI - Clinical efficacy of local application of sustained-release metronidazole in
periodontal therapy
VL - 1
ID - 13311
ER -
TY - JOUR
AB - An in situ forming gel is a dosage form which is promised for site-specific
therapy such as periodontal pocket of periodontitis treatment. Ethylcellulose,
bleached shellac, and Eudragit RS were applied in this study as a polymeric matrix
for in situ forming gel employing N-methyl pyrrolidone (NMP) as solvent. Solutions
comprising ethylcellulose, bleached shellac, and Eudragit RS in NMP were evaluated
for viscosity, rheology, and rate of water penetration. Ease of administration by
injection was determined as the force required to expel polymeric solutions through
a needle using texture analyzer. In vitro gel formation and in vitro gel
degradation were conducted after injection into phosphate buffer solution pH 6.8.
Ethylcellulose, bleached shellac, and Eudragit RS could form the in situ gel, in
vitro. Gel viscosity and pH value depended on percentage amount of the polymer,
whereas the water diffusion at early period likely relied on types of polymer.
Furthermore, the solutions containing higher polymer concentration exhibited the
lower degree of degradation. All the preparations were acceptable as injectable
dosage forms because the applied force was lower than 50 N. All of them inhibited
Staphylococcus aureus, Escherichia coli, Candida albicans, Streptococcus mutans,
and Porphyrommonas gingivalis growth owing to antimicrobial activity of NMP which
exhibited a potential use for periodontitis treatment. Moreover, the developed
systems presented as the solvent exchange induced in situ forming gel and showed
capability to be incorporated with the suitable antimicrobial active compounds for
periodontitis treatment which should be further studied.
AN - rayyan-563560310
AU - Srichan, T.
AU - Phaechamud, T.
DO - 10.1208/s12249-016-0507-1
IS - 1
ampicillin
buffer
clotrimazole
doxycycline hyclate
ethyl cellulose
eudragit rs
phosphate
shellac
antifungal activity
aqueous solution
article
bacterial growth
Candida albicans
clinical evaluation
controlled study
diffusion
drug dosage form
drug penetration
drug solution
Escherichia coli
flow kinetics
force
gel
in vitro study
nonhuman
periodontitis
pH
priority journal
viscosity
LA - English
PY - 2017
SN - 1530-9932
SP - 194-201
ST - Designing Solvent Exchange-Induced In Situ Forming Gel from Aqueous Insoluble
Polymers as Matrix Base for Periodontitis Treatment
TI - Designing Solvent Exchange-Induced In Situ Forming Gel from Aqueous Insoluble
Polymers as Matrix Base for Periodontitis Treatment
VL - 18
ID - 13684
ER -
TY - JOUR
AB - To manage periodontal disease with the use of doxycycline drug. An update to
the present findings of doxycycline in managing periodontal disease. Periodontal
disease is one of the most common microbial infections in adults. It is an
inflammatory disease of bacterial origin that affects the tooth-supporting tissues.
There are two major types of periodontal disease: gingivitis and periodontitis.
Periodontitis is characterized by general inflammation of the periodontal tissues.
Antibiotics given orally and at standard doses have some limited applications for
periodontal disease. They are typically given for an acute infection. Specific
antibiotics used in periodontal disease include: Tetracycline antibiotics includes
tetracycline hydrochloride, doxycycline, and minocycline are the primary drugs
used. They not only have anti-bacterial actions but also reduce inflammation.
Short-term use of standard-dose doxycycline is used for treating acute periodontal
infections and for eliminating inflammation. Metronidazole in combination with
tetracycline or amoxicillin may be used for severe and chronic periodontal disease.
Atridox is a doxycycline gel that conforms to the gum surface and then
solidifies.PerioChip is a chip that is placed into the gum pocket after scaling.
Periodontal disease when left untreated may cause cardiac diseases in systemic
disorders. Hence this review helps in proper management of periodontal health.
AN - rayyan-563560400
AU - Srinath, S.
IS - 4
KW - doxycycline
diarrhea
drug absorption
drug capsule
drug distribution
drug eruption
drug excretion
drug formulation
drug half life
drug tolerability
gel
gingivitis
human
injection site pain
low drug dose
nausea
nonhuman
outcome assessment
periodontal disease
periodontitis
phlebitis
photosensitivity
review
treatment response
atridox
LA - English
PY - 2015
SN - 0975-1556
SP - 252-255
ST - Management of periodontal disease with doxycycline: An update
T2 - Intl. J. Pharm. Clin. Res.
TI - Management of periodontal disease with doxycycline: An update
VL - 7
ID - 13774
ER -
TY - JOUR
AB - The aim of the current research was to formulate and evaluate herbal extracts
tooth gel of of Emblica officinalis, Terminalia bellirica, Terminalia chebula,
Trachycpermum ammi, Embelia ribes and Syzygium aromaticum, which are used for oral
hygiene, plaque control, gingivitis, anti-bacterial, astringent and prevent tooth
decay. Powders were extracted separately and further evaluated for phytochemical
screening which showed presence of phytoconstituents like alkaloids, tannins,
flavonoids and carbohydrates. A 23 factorial design was used to optimize tooth gel
using independent variables: concentration of sodium carboxymethyl cellulose (X1)
(2 and 3 %); concentration of Gantrex (X2) (0 and 1%) and concentration of sodium
lauryl sulphate (X3) (1.5 and 2.5 %) and dependent variables foaming capacity (Y1)
and zone of inhibition (Y2). Tooth gel was evaluated for color, odor, taste and pH.
Gel exhibited good viscosity, extrudability, spreadability and antimicrobial
activity. Formulation F5 showed highest foamability (48.2±0.4ml) and zone of
inhibition (4.4±0.2cm) with the desirability value 1 (most desirable response) at
design space X1 = 2%, X2 = 0%, X3 = 2.5 % and was therefore considered optimize
formulation. Formulation was found stable after 3 months of stability studies.
Thus, formulated toothgel had better results when compared with marketed
formulation. In conclusion, formulated toothgel was considered as helpful to take
care of oral hygiene of human being.
AN - rayyan-563559745
AU - Srinivasan, M.
AU - Apurva, D.
AU - Manish, W.
AU - Satish, P.
AU - Varun, P.
AU - Maitreyee, D.
AU - Ashlesha, P.
AU - Amol, T.
AU - Akshay, B.
DO - 10.52711/0974-360X.2023.00211
IS - 3
KW - liquid culture
Mueller-Hinton agar
viscometer
alkaloid
astringent agent
carbohydrate
Emblica officinalis extract
flavonoid
gel
glycoside
herbaceous agent
herbal extract
phytochemical
plant extract
saponin
sorbitol
tannin
tannin derivative
Terminalia chebula extract
tooth gel
unclassified drug
article
clove
dental caries
disk diffusion
drug formulation
Embelia ribes
factorial design
foaming
gingivitis
human
medicinal plant
moisture
mouth hygiene
odor
pH
Phyllanthus emblica
powder
Terminalia bellirica
Terminalia chebula
Trachycpermum ammi
viscosity
zone of inhibition
LA - English
PY - 2023
SN - ["0974-360X", "0974-3618"]
SP - 1283-1288
ST - Development and In-vitro Effectiveness of Tooth-gel containing Herbal
Extracts
TI - Development and In-vitro Effectiveness of Tooth-gel containing Herbal
Extracts
VL - 16
ID - 13119
ER -
TY - JOUR
AB - Alveolar bone loss and bone defects are the commonly encountered periodontal
problems. Large defects do not heal spontaneously and thus require surgical
interventions with bone substitutes. Bone grafts have the disadvantages of
eliciting an immunologic response with subsequent graft rejection. The success rate
of Guided Tissue Regeneration (GTR) is variable because of high susceptibility to
infection. Thus emerged the important role of synthetic biomaterials and hence for
this purpose we developed a nanocomposite scaffold, using alpha- and,beta-chitin
hydrogel with bioactive glass ceramic nanoparticles (nBGC) and silver nanoparticles
(nAg) by lyophilization technique (alpha- and beta-chitin hydrogel/nBGC/nAg
nanocomposite scaffold). The prepared nanoparticles and nanocomposite scaffolds
were characterized. In addition, the porosity, swelling, mechanical properties,
antibacterial activity, in vitro degradation and biomineralization, cell viability,
cell attachment and cell proliferation ability of the prepared composite scaffolds
were also evaluated. The results showed that alpha- and beta-chitin/nBGC/nAg
composite scaffolds were porous and have the capacity to absorb fluids and swell.
The composite scaffolds also showed enhanced antibacterial activity, bioactivity
and controlled degradation in comparison to the control scaffolds. Cell viability
studies proved the non-toxic nature of the nanocomposite scaffolds. Cell attachment
and cell proliferation studies revealed the attachment and spreading nature of
cells. All these studies revealed that, these antibacterial nanocomposite scaffolds
could be a promising approach for the management of periodontal defects.
AN - rayyan-563562031
AU - Srinivasan, S.
AU - Kumar, P. T. S.
AU - Nair, S. V.
AU - Chennazhi, K. P.
AU - Jayakumar, R.
DO - 10.1166/jbn.2013.1658
IS - 11
PY - 2013
SN - ["1550-7033", "1550-7041"]
SP - 1803-1816
ST - Antibacterial and Bioactive alpha- and beta-Chitin Hydrogel/Nanobioactive
Glass Ceramic/Nano Silver Composite Scaffolds for Periodontal Regeneration
T2 - JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
TI - Antibacterial and Bioactive alpha- and beta-Chitin Hydrogel/Nanobioactive
Glass Ceramic/Nano Silver Composite Scaffolds for Periodontal Regeneration
VL - 9
Y2 - 11
ID - 15405
ER -
TY - JOUR
this purpose we developed a nanocomposite scaffold, using alpha- and beta-chitin
hydrogel with bioactive glass ceramic nanoparticles (nBGC) and silver nanoparticles
(nAg) by lyophilization technique (aalpha and beta-chitin hydrogel/nBGC/nAg
nanocomposite scaffold). The prepared nanoparticles and nanocomposite scaffolds
were characterized. In addition, the porosity, swelling, mechanical properties,
were also evaluated. The results showed that alpha- and beta-chitin/nBGC/nAg
composite scaffolds were porous and have the capacity to absorb fluids and swell.
The composite scaffolds also showed enhanced antibacterial activity, bioactivity
and controlled degradation in comparison to the control scaffolds. Cell viability
could be a promising approach for the management of periodontal defects.
AN - rayyan-563560801
AU - Srinivasan, S.
AU - Kumar, P. T.
AU - Nair, S. V.
AU - Jayakumar, R.
DO - 10.1166/jbn.2013.1658
IS - 11
J2 - J Biomed Nanotechnol
KW - Anti-Bacterial Agents/chemistry/pharmacology
Bacterial Physiological Phenomena/*drug effects
Cells, Cultured
Chitin/*chemistry
Drug Implants/pharmacology
Equipment Design
Equipment Failure Analysis
Fibroblasts/*cytology/drug effects/physiology
Glass/chemistry
Guided Tissue Regeneration, Periodontal/*instrumentation
Humans
Hydrogels/chemistry
Materials Testing
Metal Nanoparticles/*administration & dosage/chemistry
Silver/chemistry/*pharmacology
*Tissue Scaffolds
LA - eng
N1 - Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of
Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi
682041, India.
PY - 2013
SN - 1550-7033 (Print)
SP - 1803-16
ST - Antibacterial and bioactive alpha- and beta-chitin hydrogel/nanobioactive
glass ceramic/nano silver composite scaffolds for periodontal regeneration
T2 - Journal of biomedical nanotechnology
TI - Antibacterial and bioactive alpha- and beta-chitin hydrogel/nanobioactive
glass ceramic/nano silver composite scaffolds for periodontal regeneration
VL - 9
Y2 - 11
ID - 14175
ER -
TY - JOUR
this purpose we developed a nanocomposite scaffold, using α- and β-chitin hydrogel
with bioactive glass ceramic nanoparticles (nBGC) and silver nanoparticles (nAg) by
lyophilization technique (α- and β-chitin hydrogel/nBGC/nAg nanocomposite
scaffold). The prepared nanoparticles and nanocomposite scaffolds were
characterized. In addition, the porosity, swelling, mechanical properties,
were also evaluated. The results showed that α- and β-chitin/nBGC/nAg composite
scaffolds were porous and have the capacity to absorb fluids and swell. The
composite scaffolds also showed enhanced antibacterial activity, bioactivity and
controlled degradation in comparison to the control scaffolds. Cell viability
could be a promising approach for the management of periodontal defects. Copyright
© 2013 American Scientific Publishers All rights reserved.
AN - rayyan-563560471
AU - Srinivasan, S.
AU - Sudheesh Kumar, P. T.
AU - Nair, S. V.
AU - Jayakumar, R.
DO - 10.1166/jbn.2013.1658
IS - 11
KW - alpha chitin hydrogel
beta chitin hydrogel
bioactive glass ceramic nanoparticle
chitin derivative
nanoparticle
silver nanoparticle
unclassified drug
absorption
article
biodegradation
biomineralization
cell adhesion
cell proliferation
cell viability
controlled study
in vitro study
lipophilicity
mechanics
periodontics
porosity
LA - English
PY - 2013
SN - ["1550-7033", "1550-7041"]
SP - 1803-1816
ST - Antibacterial and bioactive α- And β-chitin hydrogel/ nanobioactive glass
ceramic/nano silver composite scaffolds for periodontal regeneration
T2 - J. Biomed. Nanotechnol.
TI - Antibacterial and bioactive α- And β-chitin hydrogel/ nanobioactive glass
ceramic/nano silver composite scaffolds for periodontal regeneration
VL - 9
ID - 13845
ER -
TY - JOUR
AB - Background: The aim of this randomized, split-mouth, single-masked study is
to compare the efficacy of a gel and microspheres as drug-delivery systems in the
treatment of periodontal disease. Methods: Microspheres were prepared, the release
patterns of the microspheres and gel formulations were analyzed using an
ultraviolet spectrophotometer, and particle shapes were studied under a scanning
electron microscope. A split-mouth design was followed in which 30 potential sites
were identified and divided into three groups: one control group and two groups in
which microspheres or a gel was placed. Patients were recalled at 1, 3, 6, and 9
months. Clinical recordings included plaque index (PI), gingival index (GI),
probing depth (PD), and relative attachment level (RAL) measurements; subgingival
plaque was also obtained formicrobiologic examination prior to and after therapy.
Results: Microspheres had a more sustained release and a high initial drug
concentration. There was a significant improvement in the PI and GI in the initial
3 months. The results were statistically significant at P = 0.01. The mean PD
scores among scores for the three groups at baseline and follow-up visits showed a
reduction of 0.4 to 1 mm. The microbiologic parameters were also statistically
significant. Conclusion: These data suggest that the type of delivery system could
significantly influence the outcome of therapy.
AN - rayyan-563560606
AU - Srirangarajan, S.
AU - Mundargi, R. C.
AU - Ravindra, S.
AU - Setty, S. B.
AU - Aminabhavi, T. M.
AU - Thakur, S.
DO - 10.1902/jop.2010.100324
IS - 1
biomaterial
doxycycline
drug carrier
lactic acid
microsphere
polycaprolactone
polyester
polyglycolic acid
polyglactin
adult
article
bacterium
chemistry
clinical trial
comparative study
controlled study
drug effect
female
follow up
gel
human
male
microbiology
middle aged
particle size
periodontal disease
periodontal pocket
periodontics
tooth plaque
treatment outcome
LA - English
PY - 2011
SN - 0022-3492
SP - 114-121
ST - Randomized, controlled, single-masked, clinical study to compare and evaluate
the efficacy of microspheres and gel in periodontal pocket therapy
TI - Randomized, controlled, single-masked, clinical study to compare and evaluate
the efficacy of microspheres and gel in periodontal pocket therapy
VL - 82
ID - 13980
ER -
TY - JOUR
AB - Aim: The aim of the novel study was to check the efficacy of a locally
applied 2%w/w nanoemulgel (NEG) of Ketoprofen (KP) in preventing the periodontitis,
and was also checked NEG without KP to ensure the effect of eugenol in NEG as an
oil phase. Design: For experimentally induced periodontitis, sterile silk ligatures
(3/0) were placed around the crevices of the first left lower molar teeth of the
male Wistar rats. During 8 weeks, all rats were fed with 10%w/v sucrose solution.
The experimental assessment was carried out at 11 d after treatment of experimental
periodontal disease (EPD) rats by various clinical parameters like gingival index
(GI), tooth mobility (TM), alveolar bone loss (ABL), histological analysis,
detection of TNF-α, and IL-1β in gingival tissue by ELISA and the roughness were
measured by atomic force microscopy (AFM) in tapping modes. Results: After
treatment, comparison studies with EPD were performed. NEG loaded with KP prevents
significantly (p < 0.05) various parameters (GI, TM, and ABL), which were
responsible for periodontitis. The histopathology of the periodontium showed that
Group 3 (NEG loaded with KP) had a more significant reduction in inflammatory cell
infiltration, alveolar bones resorption, and cementum (p < 0.05). In the
topographical images, significant reduction in roughness of NEG loaded with KP was
observed in comparison with EPD without treatment. Conclusion: The study revealed
the great synergistic potential of the combined NEG of an anti-inflammatory drug KP
along with eugenol as the oil phase, which have potential antibacterial, analgesic,
and anesthetic properties to combat periodontal disease.
AN - rayyan-563560336
AU - Srivastava, M.
AU - Neupane, Y. R.
AU - Kumar, P.
AU - Kohli, K.
DO - 10.3109/10717544.2014.958625
IS - 7
KW - eugenol
interleukin 1beta
ketoprofen
alveolar bone
alveolar bone loss
animal experiment
animal model
animal tissue
article
cell infiltration
tooth cementum
controlled study
drug efficacy
drug potentiation
Escherichia coli
gel
gingiva
gingival index
histopathology
male
nanoemulgel
nonhuman
osteolysis
priority journal
rat
Wistar rat
LA - English
PY - 2016
SN - ["1521-0464", "1071-7544"]
SP - 2228-2234
ST - Nanoemulgel (NEG) of Ketoprofen with eugenol as oil phase for the treatment
of ligature-induced experimental periodontitis in Wistar rats
T2 - Drug Deliv.
TI - Nanoemulgel (NEG) of Ketoprofen with eugenol as oil phase for the treatment
of ligature-induced experimental periodontitis in Wistar rats
VL - 23
ID - 13710
ER -
TY - JOUR
AB - The anaerobic, Gram-negative bacillus Fusobacterium nucleatum plays a vital
role in oral biofilm formation and the development of periodontal disease. The
organism plays a central bridging role between early and late colonizers within
dental plaque and plays a protective role against reactive oxygen species. Using a
two-dimensional gel electrophoresis and mass spectrometry approach, we have
annotated 78 proteins within the proteome of F. nucleatum subsp. nucleatum and
identified those proteins whose apparent intracellular concentrations change in
response to either O2- or H2O2-induced oxidative stress. Three major protein
systems were altered in response to oxidative stress: (i) proteins of the alkyl
hydroperoxide reductase/thioredoxin reductase system were increased in
intracellular concentration; (ii) glycolytic enzymes were modified by oxidation
(i.e. D-glyceraldehyde 3-phosphate dehydrogenase, and fructose 6-phosphate
aldolase) or increased in intracellular concentration, with an accompanying
decrease in ATP production; and (iii) the intracellular concentrations of molecular
chaperone proteins and related proteins (i.e. ClpB, DnaK, HtpG, and HrcA) were
increased. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
AN - rayyan-563560597
AU - Steeves, C. H.
AU - Potrykus, J.
AU - Barnett, D. A.
AU - Bearne, S. L.
DO - 10.1002/pmic.201000631
IS - 10
KW - adenosine triphosphate
alkyl hydroperoxide reductase
chaperone
fructose bisphosphate aldolase
glycolytic enzyme
hydrogen peroxide
protein ClpB
protein DnaK
protein HrcA
protein HtpG
proteome
thioredoxin reductase
unclassified drug
article
bacterium colony
biofilm
dental caries
mass spectrometry
nonhuman
oxidation
oxidative stress
periodontal disease
priority journal
LA - English
PY - 2011
SN - ["1615-9853", "1615-9861"]
SP - 2027-2037
ST - Oxidative stress response in the opportunistic oral pathogen Fusobacterium
nucleatum
T2 - Proteomics
TI - Oxidative stress response in the opportunistic oral pathogen Fusobacterium
nucleatum
VL - 11
ID - 13971
ER -
TY - JOUR
AB - Dental diseases are among the most prevalent illnesses in humans. Many
pharmaceutical dosage forms are used to prevent and treat these diseases.
Toothpastes and mouthwashes are two of the most popular dental medicaments. A local
delivery application that prolongs the release of the drug in the mouth offers
great advantages in preventing and treating caries and periodontal diseases.
Sustained-release devices are a relatively new concept in dentistry. This paper
describes several types of sustained-release devices that are available
commercially or are in the premarketing stage.
AN - rayyan-563561018
AU - Steinberg, D.
AU - Friedman, M.
DO - 10.1615/critrevtherdrugcarriersyst.v16.i5.10
IS - 5
KW - 4 hydroxybenzoic acid ester
antiinfective agent
chlorhexidine
doxycycline
erythromycin
ethyl cellulose
fluoride
glass ionomer
metronidazole
minocycline
penicillin G
polymer
tetracycline
tooth cement
toothpaste
clinical trial
dental caries
drug dosage form
drug efficacy
drug pellet
drug release
fiber
fluoridation
gel
human
mouth hygiene
nonhuman
periodontal disease
review
tablet
tooth infection
tooth root canal
varnish
Actisite
Atridox
Elyzol
Perio Chip
LA - English
PY - 1999
SN - 0743-4863
SP - 425-459
ST - Dental drug-delivery devices: Local and sustained-release applications
TI - Dental drug-delivery devices: Local and sustained-release applications
VL - 16
ID - 14392
ER -
TY - JOUR
AB - Dental diseases are among the most prevalent human illnesses. Dental biofilm
plaque harboring cariogenic bacteria (caries-associated bacteria) is the major
pathogenic factor leading to dental caries. Subgingival plaque harboring
periopathogenic bacteria is an additional etiological factor associated with
periodontal diseases. Many pharmaceutical dosage forms are used in the prevention
and treatment of these oral diseases. Toothpastes and mouthwashes are among the
most popular dental medicaments. The main disadvantage of these delivery systems is
their low substantivity in the target site, resulting in a low penetration
coefficiency into the biofilm. A local delivery application that prolongs the
release of the active agent in the mouth offers great advantages in the prevention
and treatment of caries and periodontal diseases. Sustained-release varnishes,
containing fluorides or antibacterial agents, have been applied to hard surfaces in
the oral cavity for prevention and treatment of dental caries. Sustained-release
dosage forms such as films/chips, gels, or fibers containing antibacterial agents
or antiinflammatory agents have been inserted into the periodontal pocket to treat
periodontal diseases. These dosage forms have been shown to reduce periopathogenic
bacteria along with clinical improvements in the periodontium. An additional
advantage of sustained-release devices is high patient compliance, which is an
important factor in dental treatment. Sustained-release devices are a relatively
new concept in the dental field. It is predicted that the use of these devices at
home and in the dental clinic will increase sharply in the next decade. (C) 2000
Wiley-Liss, Inc.
AN - rayyan-563560933
AU - Steinberg, D.
AU - Friedman, M.
DO - 10.1002/1098-2299(200007/08)50:3/4<555::AID-DDR39>3.0.CO;2-P
IS - 3
chlorhexidine
doxycycline
fluoride
metronidazole
tetracycline
biodegradation
biofilm
dental caries
devices
drug dosage form
fiber
gel
mouth infection
patient compliance
periodontium
review
tooth plaque
actisite
Atridox
elyzol
Perio Chip
LA - English
PY - 2000
SN - 0272-4391
SP - 555-565
ST - Development of sustained-release devices for modulation of dental plaque
biofilm and treatment of oral infectious diseases
T2 - Drug Dev. Res.
TI - Development of sustained-release devices for modulation of dental plaque
biofilm and treatment of oral infectious diseases
VL - 50
ID - 14307
ER -
TY - JOUR
AN - rayyan-563561660
AU - Steinberg, D.
AU - Friedman, M.
DO - 10.1111/prd.12341
IS - 1
PY - 2020
SP - 176-187
ST - Sustained-release delivery of antimicrobial drugs for the treatment of
periodontal diseases: Fantasy or already reality?
T2 - Periodontology 2000
TI - Sustained-release delivery of antimicrobial drugs for the treatment of
periodontal diseases: Fantasy or already reality?
85089770434&doi=10.1111%2fprd.12341&partnerID=40&md5=32e06eb497101377a54c8aac070f92
d3
VL - 84
ID - 15034
ER -
TY - JOUR
AB - Oral diseases such as gingivitis, periodontitis, and oral cancer affect
millions of people worldwide. Much research has been conducted to understand the
pathogenetic mechanisms of these diseases and translate this knowledge into
therapeutics. This review aims to take the reader on a journey from the initial
molecular discoveries to complex regenerative issues in oral medicine. For this, a
semi‐systematic literature search was carried out in Medline and Web of Science
databases to retrieve the primary literature describing oral cell models and
biomaterial applications in oral regenerative medicine. First, an in vitro cell
model of gingival keratinocytes is discussed, which illustrates patho‐ and
physiologic principles in the context of oral epithelial homeostasis and
carcinogenesis and represents a cellular tool to understand biomaterial‐based
approaches for periodontal tissue regeneration. Consequently, a layered gradient
nonwoven (LGN) is described, which demonstrates that the key features of
biomaterials serve as candidates for oral tissue regeneration. LGN supports proper
tissue formation and obeys the important principles for molecular
mechanotransduction. Furthermore, current biomaterial‐based tissue regeneration
trends, including polymer modifications, cell‐based treatments, antimicrobial
peptides and optogenetics, are introduced to represent the full spectrum of current
approaches to oral disease mitigation and prevention. Altogether, this review is a
foray through established and new concepts in oral regenerative medicine and
illustrates the process of knowledge translation from basic molecular and cell
biological research to future clinical applications.
AN - rayyan-563559852
AU - Steinberg, T.
AU - Dieterle, M. P.
AU - Tomakidi, P.
DO - 10.3390/ijms23095288
IS - 9
KW - biomaterial
hydrogel
polymer
carcinogenesis
gingiva
homeostasis
human
in vitro study
keratinocyte
mechanotransduction
Medline
mouth disease
optogenetics
review
Web of Science
LA - English
PY - 2022
SN - ["1422-0067", "1661-6596"]
ST - Molecular Research on Oral Diseases and Related Biomaterials: A Journey from
Oral Cell Models to Advanced Regenerative Perspectives
TI - Molecular Research on Oral Diseases and Related Biomaterials: A Journey from
Oral Cell Models to Advanced Regenerative Perspectives
VL - 23
ID - 13226
ER -
TY - JOUR
AB - BACKGROUND: Aim of this research is to verify the efficacy of metronidazole
dental gel 25%, used as a topical antibiotic for the treatment of peri-implantitis.
The efficacy of the medicine in the starting phase of the disease (mucositis), as
well as during peri-implantitis involving bone-bearing loss has been evaluated.
METHODS: Twenty patients were chosen as a sample for the study. After careful
evaluation of the several protocols concerning peri-implantitis treatment, some
diagnostic clinical parameters have been recorded for each patient and
metronidazole dental gel 25% (Elyzol Cabon) has been administered in two
applications at perimplants pocket (one after a week). For each patient 3
microbiological drawings were made for the evaluation of the bacterial population
around the implant site. RESULTS: From the microbiological examination a decrease
of Gram- and an increase of Gram+ which returned in almost all the patients to
normal levels have been observed; moreover, in all the patients a gradual decrease
of PMN, resolution index of the inflammatory process was obtained, confirmed also
by a remarkable improvement of all the observed diagnostic parameters, except for
the peri-implants bone radiotransparency which was unchanged. CONCLUSIONS: The
research showed that the peri-implant diseases can be positively resolved by using
the metronidazole dental gel 25% topical antibiotic. This drug led to a 60-70%
decrease of Gram-, and 40-50% increase for Gram+, bringing these back to normal
values in almost all the patients. Moreover, a good recovery of the peri-implants
soft tissues has been observed.
AN - rayyan-563560996
AU - Stellini, E.
AU - Migliorato, A.
AU - Mazzoleni, S.
AU - Mottola, A.
AU - Lombardi, L.
AU - Favero, G. A.
IS - 1
metronidazole
adult
aged
article
bacterium
comparative study
evaluation study
female
gel
human
infection
male
microbiology
middle aged
mouth
periodontitis
time
tooth implantation
LA - Italian
PY - 2000
SN - 0026-4970
SP - 59-67
ST - Topical treatment of peri-implantitis with metronidazole dental gel 25%.
Clinical analysis and microbiological control
T2 - Trattamento topico delle perimplantiti con metronidazolo gel dentale 25%.
Analisi clinica e controllo microbiologico.
TI - Topical treatment of peri-implantitis with metronidazole dental gel 25%.
Clinical analysis and microbiological control
VL - 49
ID - 14370
ER -
TY - JOUR
AB - The aim of this study was to compare the topical application of a
metronidazole 25% dental gel with subgingival scaling. 30 patients from the recall
program participated in this open randomised study with split-mouth design. Pocket
probing depths (PPD) and bleeding on probing (BOP) were measured before and 2, 12
and 24 weeks after the end of the treatment period. In addition, subgingival plaque
samples were taken from all mesial sites and analysed with dark-field microscopy.
All patients had at least 1 tooth in each quadrant with a PPD of 5 mm or more that
should bleeding on probing, when entering the study. The treatment consisted of 2
applications of the dental gel in 2 randomly selected quadrants (on days 0 and 7)
as well as simultaneous subgingival scaling of the remaining quadrants. Oral
hygiene instruction was given on day 21. The average PPD and the average frequency
of BOP were calculated for all sites with an initial PPD of 5 mm or more and
continued at each examination, using the same sites. The statistical analyses
showed that both treatments were effective in reducing PPD and BOP over the 6-month
period. At the end of the follow-up period, the mean reduction in PPD was 1.3 mm
after gel treatment and 1.5 mm after subgingival scaling. BOP was reduced by 35%
and 42%, respectively. No significant differences between the 2 treatments were
detected. Dark-field microscopy showed a shift toward a more healthy microflora for
both treatment modalities; this persisted throughout the 6-month period.
Application of a 25% metronidazole dental gel on recall patients seems to be as
effective on the investigated clinical and microbiological parameters as
subgingival scaling.
AN - rayyan-563561067
AU - Stelzel, M.
AU - Florès-de-Jacoby, L.
IS - 1
KW - metronidazole
adult
aged
article
bacterial count
bacterium
classification
clinical trial
comparative study
controlled study
female
follow up
gel
gingiva bleeding
human
male
microbiology
middle aged
mouth hygiene
pathology
periodontics
periodontitis
tooth plaque
LA - English
PY - 1996
SN - 0303-6979
SP - 24-29
ST - Topical metronidazole application compared with subgingival scaling. A
clinical and microbiological study on recall patients
TI - Topical metronidazole application compared with subgingival scaling. A
clinical and microbiological study on recall patients
VL - 23
ID - 14441
ER -
TY - JOUR
AB - The aim of this randomised study in split-mouth design, in which 24 patients
from the recall programme of Marburg University Department of Periodontology were
enrolled, was to compare topical application of a metronidazole 25% dental gel with
subgingival scaling. The clinical parameters used were pocket probing depth (PPD)
and bleeding on probing (BOP); these were recorded at baseline and 1, 3, 6, 14, 18
and 24 months after completion of treatment. In addition, plaque samples were taken
from all mesial pockets for evaluation by dark-field microscopy. All patients had
at least one tooth in each quadrant with a PPD of 5 mm or more showing BOP when
they entered the study. The treatment consisted of 2 applications of dental gel in
2 randomly selected quadrants (on days 0 and 7) as well as subgingival scaling of
the remaining quadrants. Statistical evaluation of all sites with a baseline PPD of
5 mm or more showed that both methods led to a significant reduction in PPD and BOP
in the first 6 months. The average reduction in PPD was 1.3 mm in the gel group and
1.5 mm in the scaling group, with the tendency to bleeding being reduced by ca. 50%
in both groups. After 24 months, improvements of 0.6 mm and 0.5 mm respectively
were observed in PPD. The tendency to bleeding had undergone a slight increase but
was still below baseline values. No statistically significant differences were
observed between the two methods, although the results recorded with subgingival
scaling were slightly better. Dark-field microscopy revealed a shift in the
composition of the bacterial flora, suggesting a more physiological situation,
which was maintained for 6 months before reverting consistently after 18 months to
the baseline values of the plaque composition. Overall, application of a
metronidazole 25% dental gel led in recall patients to an improvement in the
investigated clinical and microbiological parameters comparable with subgingival
scaling. After 24 months, the clinical parameters still displayed a very slight
improvement over baseline values; after 18 months the microflora had reverted to
its baseline composition.
AN - rayyan-563561035
AU - Stelzel, M.
AU - Flores-de-Jacoby, L.
IS - 12
metronidazole
adult
aged
article
bacterium
classification
clinical trial
comparative study
controlled study
female
follow up
gel
gingiva bleeding
human
longitudinal study
male
microbiology
middle aged
periodontics
periodontitis
spirochete
tooth plaque
LA - English
PY - 1997
SN - 0303-6979
SP - 914-919
ST - Topical metronidazole application in recall patients. Long-term results
TI - Topical metronidazole application in recall patients. Long-term results
VL - 24
ID - 14409
ER -
TY - JOUR
AB - AIM: This study was carried out to investigate the effect of 2 applications
of a metronidazole 25% dental gel as adjunctive therapy to subgingival scaling with
root planing. METHOD: 59 of the original collective of 64 patients with adult
periodontitis were observed for a 9-month period. This randomised single-blind
study was carried out in split-mouth design. Each patient had to have at least 2
pockets with a probing depth of > or =5 mm in each quadrant. The clinical
parameters, pocket probing depth (PPD), attachment level (AL) and bleeding on
probing (BOP), were recorded at all teeth on days 0, 91, 175 and 259; in addition,
subgingival plaque samples taken from 45 patients were analysed by means of dark-
field microscopy. Therapy comprised subgingival scaling and root planing (SRP) of
all quadrants and additional application of metronidazole 25%, dental gel in 2
randomly selected quadrants (SRP+Metro). Treatment was confined to teeth with a
baseline PPD of > or =5 mm. Average PPD and AL and the incidence of BOP were
computed for all pockets with a baseline PPD of > or =5 mm, and the 2 methods
compared. The main efficacy variable for evaluation of the 2 treatments was the
difference in PPD on day 259. RESULTS: Comparison of the 2 treatments revealed a
statistically significant improvement in the clinical parameters for both treatment
methods over the study period. Between baseline and day 259, significant
differences in PPD (SRP+Metro: from 6.00 to 4.63 mm, SRP: from 6.02 to 4.83 mm) and
BOP (SRP+Metro: from 67 to 31%, SRP: from 64 to 36%) were observed between the 2
treatment groups. Evaluation according to different patient groups demonstrated
significant advantages of the combined therapy in previously-untreated patients,
especially in female probands. Dark-field microscopy revealed a shift in the
bacterial flora towards "healthy conditions". CONCLUSIONS: The results show that
only minor advantages are to be gained from the application of a metronidazole 25%
dental gel as adjunctive therapy to subgingival scaling. The distinctly better
results of combined therapy in previously-untreated patients calls for more
thorough investigation.
AN - rayyan-563560937
AU - Stelzel, M.
AU - Florès-de-Jacoby, L.
IS - 6
metronidazole
adult
aged
article
clinical trial
comparative study
controlled study
female
human
male
middle aged
periodontitis
LA - English
PY - 2000
SN - 0303-6979
SP - 447-452
ST - Topical metronidazole application as an adjunct to scaling and root planing
TI - Topical metronidazole application as an adjunct to scaling and root planing
VL - 27
ID - 14311
ER -
TY - JOUR
AB - Introduction/Objective The aim of this study was to determine clinical and
radiographic periapical healing of teeth with apical periodontitis treated with
different formulations of calcium hydroxide (CH) - paste (CH-paste) and gutta-
percha points (CH-GP) - as well as those of chlorhexidine (CHX) -gel (CHX-gel) and
gutta-percha points (CHX-GP) -12 months after therapy. Methods Eighty patients with
chronic apical periodontitis were randomly allocated to four treatment groups
according to the intracanal medicament used: CH-paste, CH-GP, CHX-gel, and CHX-GP
group. Seventy-eight patients were analyzed clinically and radiographically 12
months postoperatively. The periapical index (PAI) was used for the radiographic
evaluation of treatment. Results Overall outcome was classified according to
radiographic evaluation only, since clinical success was observed in all the
patients. In all the groups, significant reduction in PAI scores was observed (p <
0.001). The proportions of healed teeth (PAI <= 2) were 73.7%, 60%, 68.4%, and 65%
in CH-paste, CH-GP, CHX-gel and CHX-GP group, respectively, with no significant
differences between the groups. Conclusion The results suggest that there are no
differences between investigated CH- and CHX-delivery systems regarding treatment
outcome of teeth with apical periodontitis.
AN - rayyan-563562481
AU - Stojanovic, N.
AU - Krunic, J.
AU - Mladenovic, I.
AU - Stojanovic, Z.
AU - Apostolska, S.
AU - Zivkovic, S.
DO - 10.2298/SARH170221139S
IS - 3
PY - 2018
SN - 0370-8179
SP - 143-148
ST - Influence of different forms of calcium hydroxide and chlorhexidine
intracanal medicaments on the outcome of endodontic treatment of teeth with chronic
apical periodontitis
T2 - SRPSKI ARHIV ZA CELOKUPNO LEKARSTVO
TI - Influence of different forms of calcium hydroxide and chlorhexidine
intracanal medicaments on the outcome of endodontic treatment of teeth with chronic
apical periodontitis
VL - 146
Y2 - 3
ID - 15855
ER -
TY - JOUR
AN - rayyan-563561146
AU - Stoltze, K.
IS - 9
KW - metronidazole
anaerobic bacterium
clinical article
conference paper
drug tissue level
human
periodontal disease
LA - English
PY - 1992
SN - 0303-6979
SP - 698-701
ST - Concentration of metronidazole in periodontal pockets after application of a
metronidazole 25% dental gel
TI - Concentration of metronidazole in periodontal pockets after application of a
metronidazole 25% dental gel
VL - 19
ID - 14520
ER -
TY - JOUR
AB - Elyzo 25% Dentalgel (EDG) which is developed for use in the treatment of
periodontitis is a suspension of metronidazole benzoate (40%) in a mixture of
glyceryl mono-oleate (GMO) and triglyceride (sesame oil). Metronidazole can be
detected in the periodontal pockets 24-36 h after application. The aim of the
present study was to estimate the period of time that the gel matrix persists on
periodontal pockets after 1 application of EDG. 12 patients were included in the
study. From each patient, 1 sample was taken before and immediately after, and 1,
2, 3, 4, 5, 6, 8, 12 and 24 h after application. Subgingival scaling followed by
absorption of gingival crevicular fluid with filter paper was used for sampling.
The sampling unit was 1 tooth. Each sample was assayed for the amount of GMO and
oleic acid (a degradation product of GMO) by means of high-performance liquid
chromatography (HPLC) with UV detection. To allow determination of the GMO dose
applied into the pockets and to estimate the recovery rate of the sampling method,
1 tooth in each patient was selected for sampling as soon as the gel had set, i.e.,
about 10 min after application. Only in 1 patient was a detectable amount of GMO
within the pocket revealed 24 h after application. This amount was approximately
0.5% of the mean GMO dose applied around 1 tooth. GMO was found no longer than 12 h
in the remaining patients.
AN - rayyan-563561070
AU - Stoltze, K.
IS - 3
KW - acylglycerol
drug derivative
Elyzol Dentalgel
glycerol oleate
metronidazole
oleic acid
sesame seed oil
absorption
adult
article
chemistry
female
gel
gingivitis
human
male
metabolism
middle aged
periodontitis
time
LA - English
PY - 1995
SN - 0303-6979
SP - 185-187
ST - Elimination of Elyzol 25% Dentalgel matrix from periodontal pockets
TI - Elimination of Elyzol 25% Dentalgel matrix from periodontal pockets
VL - 22
ID - 14444
ER -
TY - JOUR
AN - rayyan-563561145
AU - Stoltze, K.
AU - Stellfeld, M.
IS - 9
KW - metronidazole
clinical article
conference paper
dentistry
drug absorption
drug blood level
female
human
male
periodontitis
LA - English
PY - 1992
SN - 0303-6979
SP - 693-697
ST - Systemic absorption of metronidazole after application of a metronidazole 25%
dental gel
TI - Systemic absorption of metronidazole after application of a metronidazole 25%
dental gel
VL - 19
ID - 14519
ER -
TY - JOUR
AB - Aim: To analyze and compare the effectiveness of two antibacterial gels in
the treatment of mucositis. Methods: After signing the informed consent, in
accordance with the Helsinki Declaration of 1975, revised in 2000, 21 patients were
included in the study and divided by randomization into two groups. At the
baseline, the modified bleeding index (mBI) and plaque index (PI) values were
measured, and an oral hygiene and implant disinfection session was carried out. The
session was repeated at 7, 15, and 30 days and after 2 and 3 months from the
baseline. Two products were used-a bioadhesive gel in the test group and a 1%
chlorhexidine gel in the control group. Results: Due to three dropouts, the final
sample was composed of 18 patients. An improvement in periodontal indices was
observed, similar to mBI and PI values, in both groups. There were no complications
except for the appearance of pigmentations in the control group. Conclusions: The
antibacterial power and effectiveness of the two gels are comparable. Considering
the small sample size of the study cohort, further studies are needed to validate
the results obtained from this pilot study.
AN - rayyan-563562495
AU - Storelli, S.
AU - Palandrani, G.
AU - Manfredi, B.
AU - Romeo, E.
AU - De Martis, D.
AU - Todaro, C.
AU - Baena, R.
AU - Lupi, S. M.
DO - 10.3390/app13031288
IS - 3
PY - 2023
SN - 2076-3417
ST - Difference of Two Antiseptic Gels for the Treatment of Peri-Implant Mucositis
on Plaque Index and Bleeding Score: A Randomized Controlled Clinical Study
TI - Difference of Two Antiseptic Gels for the Treatment of Peri-Implant Mucositis
VL - 13
Y2 - 2
ID - 15869
ER -
TY - JOUR
AN - rayyan-563561496
AU - Storelli, S.
AU - Palandrani, G.
AU - Manfredi, B.
AU - Romeo, E.
AU - De Martis, D.
AU - Todaro, C.
AU - Rodriguez y Baena, R.
AU - Lupi, S. M.
DO - 10.3390/app13031288
IS - 3
PY - 2023
ST - Difference of Two Antiseptic Gels for the Treatment of Peri-Implant Mucositis
TI - Difference of Two Antiseptic Gels for the Treatment of Peri-Implant Mucositis
85147876793&doi=10.3390%2fapp13031288&partnerID=40&md5=7d1e2dafab1920ca50937dbe749d
d92c
VL - 13
ID - 14870
ER -
TY - JOUR
AB - Triclosan is currently one of the most researched antimicrobial agents of the
oral cavity. A consensus meeting organized by Colgate-Palmolive Romania took place
on 15 February 2008 at Athenee Palace Hilton Bucharest to reunite the conclusions
of Romanian opinion leaders regarding the applicability of triclosan in dental
medicine and the triclosan-PVM/MA copolymer technology. The article refects the
data issued by the consensus meeting regarding the value of triclosan as
therapeutic agent of the periodontal disease. With respect to the triclosan -
PVM/MA copolymer combination and periodontitis, the literature contains lots of
evidence confrming the interest to include the triclosan - PVM/MA copolymer
combination in periodontal disease therapy. However, the feld of parallel studies
using toothpastes or gels containing other antimicrobial agents is nowadays
limited. A more extended research is necessary, especially concerning the
correlation of in vitro with the in vivo data.
AN - rayyan-563560614
AU - Stratul, S. I.
AU - Onisei, D.
AU - Rusu, D.
IS - 1
KW - chlorhexidine
enoyl acyl carrier protein reductase (NADH)
gantrez copolymer
placebo
toothpaste
triclosan
article
clinical trial
consensus development
disease severity
drug efficacy
drug formulation
drug mechanism
drug research
follow up
gel
gingivitis
human
in vitro study
in vivo study
mouth hygiene
periodontal disease
periodontitis
tooth plaque
treatment outcome
LA - English
PY - 2010
SN - ["1583-5251", "1583-526X"]
SP - 94-96
ST - The triclosan - PVM/MA copolymer combination and periodontitis. data from A
consensus report - Part II
T2 - Timis. Med. J.
TI - The triclosan - PVM/MA copolymer combination and periodontitis. data from A
consensus report - Part II
VL - 60
ID - 13988
ER -
TY - JOUR
AB - The aim of the study was to evaluate the impact of smoking on a prolongated
chlorhexidine digluconate regimen after scaling and root planing. Forty-two smokers
(test group) and 85 nonsmoking patients (control group) with generalized chronic
periodontitis were examined for clinical attachment level (CAL), probing depth
(PD), bleeding on probing (BoP), and Plaque Index (Pl) at baseline and after 1 and
3 months. During scaling and root planing, a 0.2% chlorhexidine digluconate
solution and a 1% chlorhexidine digluconate gel were used. The subjects used a 0.2%
chlorhexidine digluconate solution twice daily for 3 months. The Mann-Whitney U and
Wilcoxon tests were used for statistical analysis. There were significant
improvements of all studied variables after 1 and 3 months in both groups. After 3
months, the mean improvement in the test group was 1.62 mm for CAL, 2.85 mm for PD,
and 48% for BoP; in the control group, the values were 2.18 mm for CAL, 2.81 mm for
PD, and 47% for BoP. Only the maximum changes of CAL between 1 and 3 months (test
group, 0.32 mm vs 0.69 mm in the control group) and PD (test group, 0.47 mm vs 0.76
mm in the control group) were significantly different between the groups (P < .05
and P = .05, respectively). The present data appear to suggest that the use of
chlorhexidine digluconate twice daily during a period of 3 months following
nonsurgical periodontal therapy may result in significant clinical improvements in
smokers and nonsmokers.
AN - rayyan-563560585
AU - Stratul, S. I.
AU - Sculean, A.
AU - Rusu, D.
AU - Didilescu, A.
AU - Kasaj, A.
AU - Jentsch, H.
IS - 7
KW - chlorhexidine
drug derivative
mouthwash
adult
article
clinical trial
comparative study
controlled study
follow up
gel
gingiva bleeding
human
middle aged
periodontal disease
periodontal pocket
pilot study
prospective study
smoking
taste disorder
tooth discoloration
tooth plaque
LA - English
PY - 2011
SN - 1936-7163
SP - 555-563
ST - Effect of smoking on the results of a chlorhexidine digluconate treatment
extended up to 3 months after scaling and root planing-a pilot study
TI - Effect of smoking on the results of a chlorhexidine digluconate treatment
extended up to 3 months after scaling and root planing-a pilot study
VL - 42
ID - 13959
ER -
TY - JOUR
AB - Phenotypic transformation of macrophages plays important immune response
roles in the occurrence, development and regression of periodontitis. Under
inflammation or other environmental stimulation, mesenchymal stem cells (MSCs)
exert immunomodulatory effects through their secretome. It has been found that
secretome derived from lipopolysaccharide (LPS)-pretreated or three-dimensional
(3D)-cultured MSCs significantly reduced inflammatory responses in inflammatory
diseases, including periodontitis, by inducing M2 macrophage polarization. In this
study, periodontal ligament stem cells (PDLSCs) pretreated with LPS were 3D
cultured in hydrogel (termed SupraGel) for a certain period of time and the
secretome was collected to explore its regulatory effects on macrophages.
Expression changes of immune cytokines in the secretome were also examined to
speculate on the regulatory mechanisms in macrophages. The results indicated that
PDLSCs showed good viability in SupraGel and could be separated from the gel by
adding PBS and centrifuging. The secretome derived from LPS-pretreated and/or 3D-
cultured PDLSCs all inhibited the polarization of M1 macrophages, while the
secretome derived from LPS-pretreated PDLSCs (regardless of 3D culture) had the
ability to promote the polarization of M1 to M2 macrophages and the migration of
macrophages. Cytokines involved in the production, migration and polarization of
macrophages, as well as multiple growth factors, increased in the PDLSC-derived
secretome after LPS pretreatment and/or 3D culture, which suggested that the
secretome had the potential to regulate macrophages and promote tissue
regeneration, and that it could be used in the treatment of inflammation-related
diseases such as periodontitis in the future.
AN - rayyan-563559733
AU - Su, Y.
AU - Ai, S.
AU - Shen, Y.
AU - Cheng, W.
AU - Xu, C.
AU - Sui, L.
AU - Zhao, Y.
DO - 10.3390/ijms24086981
IS - 8
KW - cell culture plate
conditioned medium
alpha2 interferon
arginine
chemokine
complementary DNA
cytokine
growth factor
hydrogel
interleukin 10
interleukin 1beta
interleukin 2 receptor alpha
interleukin 6
interleukin 8
interleukin 9
lipopolysaccharide
messenger RNA
peptide
RANTES
RNA
scatter factor
stem cell growth factor
stromal cell derived factor 1alpha
tumor necrosis factor related apoptosis inducing ligand
unclassified drug
vasculotropin
animal cell
article
cell viability
controlled study
gene expression
human
human cell
immunomodulation
inflammation
M1 macrophage
M2 macrophage
macrophage
macrophage migration
mouse
nonhuman
periodontitis
polarization
protein expression
RAW 264.7 cell line
secretome
three dimensional cell culture
tissue regeneration
wound healing
LA - English
PY - 2023
SN - ["1422-0067", "1661-6596"]
ST - Regulatory Effects of Three-Dimensional Cultured Lipopolysaccharide-
Pretreated Periodontal Ligament Stem Cell-Derived Secretome on Macrophages
TI - Regulatory Effects of Three-Dimensional Cultured Lipopolysaccharide-
Pretreated Periodontal Ligament Stem Cell-Derived Secretome on Macrophages
VL - 24
ID - 13107
ER -
TY - JOUR
AB - Dental caries, plaque. Periodontal diseases and root canal treatment failure
are all associated with oral pathogens. Several plant derivatives have been
evaluated with respect to their antimicrobial effects against such pathogenic
microorganisms. Aloe vera is one such medicinal plant with antiinflammatory,
antimicrobial, antidiabetic and immune-boosting properties. This review has the
compiled data of the antibacterial activity of Aloe vera against cariogenic S.
mutans, periodontopathic A. actinomycetemcomitans, P. gingivalis, and B. fragilis,
Candida albicans and E. faecalis.
AN - rayyan-563560509
AU - Subashree Rathi, S.
AU - Thangavelu, L.
IS - 1
herbaceous agent
Aloe vera
anticariogenic activity
antifungal activity
antiperiodontopathic activity
antiplaque activity
article
Bacteroides fragilis
Candida albicans
dentistry
drug activity
gel
gingivitis
herbal medicine
human
mouth plaque
nonhuman
plant leaf
tooth root canal
LA - English
PY - 2013
SN - 0975-8216
SP - 1-5
ST - Role of Aloe vera in dental practice- a review
T2 - Pharma Res.
TI - Role of Aloe vera in dental practice- a review
VL - 10
ID - 13883
ER -
TY - JOUR
AB - Periodontitis is an inflammatory disease of the supportive tissues
surrounding the teeth which is seen world wide in all groups of people. Various
methods of treatments were used in the management of periodontal
infection(1).Various effective methods including mechanical debridement of plaque,
topical and systemic administration of antibacterial agents in the treatment of
such conditions. There are various options of antimicrobials which can be locally
delivered such as metronidazole, chlorhexidine, doxycycline and tetracycline(2)
AN - rayyan-563560100
AU - Subramaniam, D.
AU - Pavithra, D.
IS - 8
chlo site
chlorhexidine
doxycycline
drug carrier
ethyl cellulose
gel
metronidazole
microsphere
minocycline
periocol cg
tetracycline
unclassified drug
article
drug contraindication
human
ointment
periodontal disease
LA - English
PY - 2020
SN - 2515-8260
SP - 1874-1881
ST - Local drug delivery in periodontics - A review
TI - Local drug delivery in periodontics - A review
VL - 7
ID - 13474
ER -
TY - JOUR
AB - Peptide nucleic acids (PNA) are DNA/RNA analogs in which the sugar-phosphate
backbone is replaced by N-2-aminoethylglycine. PNA are widely used for experimental
antisense therapy due to their strong affinity to mRNA. By targeting specific
genes, protein synthesis and the growth of bacteria or cancer cells can be
inhibited by PNA. Here, we report the design and evaluation of antisense PNA for
selective growth inhibition of Porphyromonas gingivalis and Aggregatibacter
actinomycetemcomitans, potent pathogens associated with periodontitis. Antisense
PNA against groEL and acpP were prepared with carrier peptide (KFFKFFKFFK). Anti-
groEL PNA for P. gingivalis specifically inhibited growth in a dose-dependent
manner, and growth was inhibited for 5 h at a concentration of 3 μM. Anti-groEL PNA
for A. actinomycetemcomitans inhibited growth for 2 h at a concentration of 3 μM
with reduced GroEL protein expression. Anti-acpP PNA did not show a marked growth
inhibitory effect on either species. Although further studies are needed to develop
more effective antisense PNA for both species, anti-groEL PNA may be potentially
useful species-specific antibacterial tools against oral pathogens.
AN - rayyan-563560201
AU - Sugimoto, S.
AU - Maeda, H.
AU - Kitamatsu, M.
AU - Nishikawa, I.
AU - Shida, M.
DO - 10.1016/j.mcp.2018.11.006
chaperonin 60
peptide nucleic acid
antisense therapy
article
bacterial cell
bacterial growth
bacterial microbiome
bacterial strain
bacterium culture
cancer cell
cell growth
Escherichia coli K-12
growth curve
growth inhibition
infectious agent
nonhuman
periodontitis
priority journal
protein expression
protein synthesis
target organism
Western blotting
LA - English
PY - 2019
SN - ["1096-1194", "0890-8508"]
SP - 45-49
ST - Selective growth inhibition of Porphyromonas gingivalis and Aggregatibacter
actinomycetemcomitans by antisense peptide nucleic acids
T2 - Mol. Cell. Probes
TI - Selective growth inhibition of Porphyromonas gingivalis and Aggregatibacter
actinomycetemcomitans by antisense peptide nucleic acids
VL - 43
ID - 13575
ER -
TY - JOUR
AB - Goals The commercially available saliva substitute Oralbalance (R) has been
reported to alleviate symptoms of post-radiotherapy xerostomia in head and neck
cancer patients. Oralbalance (R) may also be effective for xerostomia in patients
undergoing hematopoietic cell transplantation (HCT) with high-dose chemotherapy and
total-body irradiation. However, HCT patients are severely compromised, and saliva
substitute must therefore not promote infection. This study was performed to
determine the effects of Oralbalance (R) on microbial species identified during
HCT. Patients and methods Microbial identification of oral mucosa was performed in
28 patients undergoing HCT. The antimicrobial effects of Oralbalance (R) against
bacteria and fungi detected in the HCT period were examined in vitro. Briefly,
bacteria and fungi were spread on agar plates, and 0.1g of Oralbalance (R) gel was
applied (about phi 1cm). After incubation at 37 degrees C for 24h, the presence of
a transparent zone of inhibition around Oralbalance (R) was observed. Main results
Not only bacterial species constituting normal flora of the oral mucosa but also
those not usually constituting normal flora, e.g., coagulase-negative
Staphylococcus, were detected. A transparent zone was observed around Oralbalance
(R) in all bacterial species examined. No transparent zone was observed for Candida
albicans, but growth was inhibited in the area where Oralbalance (R) was applied.
Conclusions Oralbalance (R) does not facilitate increases in microorganisms in the
HCT period. Oral care with Oralbalance (R) does not promote infection in patients
undergoing HCT.
AN - rayyan-563562503
AU - Sugiura, Y.
AU - Soga, Y.
AU - Tanimoto, I.
AU - Kokeguchi, S.
AU - Nishide, S.
AU - Kono, K.
AU - Takahashi, K.
AU - Fujii, N.
AU - Ishimaru, F.
AU - Tanimoto, M.
AU - Yamabe, K.
AU - Tsutani, S.
AU - Nishimura, F.
AU - Takashiba, S.
DO - 10.1007/s00520-007-0391-z
IS - 4
PY - 2008
SN - ["0941-4355", "1433-7339"]
SP - 421-424
ST - Antimicrobial effects of the saliva substitute, Oralbalance (R), against
microorganisms from oral mucosa in the hematopoietic cell transplantation period
T2 - SUPPORTIVE CARE IN CANCER
TI - Antimicrobial effects of the saliva substitute, Oralbalance (R), against
VL - 16
Y2 - 4
ID - 15877
ER -
TY - JOUR
AB - GOALS: The commercially available saliva substitute Oralbalance has been
cancer patients. Oralbalance may also be effective for xerostomia in patients
determine the effects of Oralbalance on microbial species identified during HCT.
PATIENTS AND METHODS: Microbial identification of oral mucosa was performed in 28
patients undergoing HCT. The antimicrobial effects of Oralbalance against bacteria
and fungi detected in the HCT period were examined in vitro. Briefly, bacteria and
fungi were spread on agar plates, and 0.1g of Oralbalance gel was applied (about
phi1cm). After incubation at 37 degrees C for 24h, the presence of a transparent
zone of inhibition around Oralbalance was observed. MAIN RESULTS: Not only
bacterial species constituting normal flora of the oral mucosa but also those not
usually constituting normal flora, e.g., coagulase-negative Staphylococcus, were
detected. A transparent zone was observed around Oralbalance in all bacterial
species examined. No transparent zone was observed for Candida albicans, but growth
was inhibited in the area where Oralbalance was applied. CONCLUSIONS: Oralbalance
does not facilitate increases in microorganisms in the HCT period. Oral care with
Oralbalance does not promote infection in patients undergoing HCT.
AN - rayyan-563561414
AU - Sugiura, Y.
AU - Soga, Y.
AU - Tanimoto, I.
AU - Kokeguchi, S.
AU - Nishide, S.
AU - Kono, K.
AU - Takahashi, K.
AU - Fujii, N.
AU - Ishimaru, F.
AU - Tanimoto, M.
AU - Yamabe, K.
AU - Tsutani, S.
AU - Nishimura, F.
AU - Takashiba, S.
DO - 10.1007/s00520-007-0391-z
IS - 4
J2 - Support Care Cancer
KW - Adult
Bacteria/drug effects/isolation & purification
Female
Fungi/drug effects/isolation & purification
*Hematopoietic Stem Cell Transplantation/adverse effects
Humans
Male
Middle Aged
Mouth/*microbiology
Mouth Mucosa/drug effects/microbiology
Saliva, Artificial/*pharmacology
LA - eng
N1 - Department of Pathophysiology-Periodontal Science, Okayama University
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-
cho, Okayama, 700-8525, Japan.
PY - 2008
SN - 0941-4355 (Print)
SP - 421-4
ST - Antimicrobial effects of the saliva substitute, Oralbalance, against
T2 - Supportive care in cancer : official journal of the Multinational Association
of Supportive Care in Cancer
TI - Antimicrobial effects of the saliva substitute, Oralbalance, against
VL - 16
Y2 - 4
ID - 14788
ER -
TY - JOUR
AB - Goals: The commercially available saliva substitute Oralbalance® has been
cancer patients. Oralbalance® may also be effective for xerostomia in patients
determine the effects of Oralbalance® on microbial species identified during HCT.
Patients and methods: Microbial identification of oral mucosa was performed in 28
patients undergoing HCT. The antimicrobial effects of Oralbalance® against bacteria
and fungi detected in the HCT period were examined in vitro. Briefly, bacteria and
fungi were spread on agar plates, and 0.1g of Oralbalance® gel was applied (about
φ1cm). After incubation at 37°C for 24h, the presence of a transparent zone of
inhibition around Oralbalance® was observed. Main results: Not only bacterial
species constituting normal flora of the oral mucosa but also those not usually
constituting normal flora, e.g., coagulase-negative Staphylococcus, were detected.
A transparent zone was observed around Oralbalance® in all bacterial species
examined. No transparent zone was observed for Candida albicans, but growth was
inhibited in the area where Oralbalance® was applied. Conclusions: Oralbalance®
does not facilitate increases in microorganisms in the HCT period. Oral care with
Oralbalance® does not promote infection in patients undergoing HCT. © 2007
Springer-Verlag.
AN - rayyan-563560715
AU - Sugiura, Y.
AU - Soga, Y.
AU - Tanimoto, I.
AU - Kokeguchi, S.
AU - Nishide, S.
AU - Kono, K.
AU - Takahashi, K.
AU - Fujii, N.
AU - Ishimaru, F.
AU - Tanimoto, M.
AU - Yamabe, K.
AU - Tsutani, S.
AU - Nishimura, F.
AU - Takashiba, S.
DO - 10.1007/s00520-007-0391-z
IS - 4
KW - oralbalance
saliva substitute
adult
article
bacterial infection
bacterium
Candida albicans
clinical article
coagulase negative Staphylococcus
controlled study
drug effect
drug efficacy
drug sensitivity
female
fungus
fungus growth
hematopoietic stem cell transplantation
human
immunocompromised patient
in vitro study
incubation time
male
microbial identification
mouth flora
mouth infection
mouth mucosa
mycosis
nonhuman
priority journal
xerostomia
LA - English
PY - 2008
SN - 0941-4355
SP - 421-424
ST - Antimicrobial effects of the saliva substitute, Oralbalance®, against
T2 - Supportive Care Cancer
TI - Antimicrobial effects of the saliva substitute, Oralbalance®, against
VL - 16
ID - 14089
ER -
TY - JOUR
AB - The present study aimed to develop a local dental nanoemulgel formulation of
Nigella sativa oil (NSO) for the treatment of periodontal diseases. NSO purchased
from a local market was characterized using a GC-MS technique. A nanoemulsion
containing NSO was prepared and incorporated into a methylcellulose gel base to
develop the nanoemulgel formulation. The developed formulation was optimized using
a Box-Behnken statistical design (quadratic model) with 17 runs. The effects of
independent factors, such as water, oil, and polymer concentrations, were studied
on two dependent responses, pH and viscosity. The optimized formulation was further
evaluated for droplet size, drug release, stability, and antimicrobial efficacy.
The developed formulation had a pH of 7.37, viscosity of 2343 cp, and droplet size
of 342 ± 36.6 nm. Sustained release of the drug from the gel for up to 8 h was
observed, which followed Higuchi release kinetics with non-Fickian diffusion. The
developed nanoemulgel formulation showed improved antimicrobial activity compared
to the plain NSO. Given the increasing emergence of periodontal diseases and
antimicrobial resistance, an effective formulation based on a natural antibacterial
agent is warranted as a dental therapeutic agent.
AN - rayyan-563559889
AU - Sultan, M. H.
AU - Javed, S.
AU - Madkhali, O. A.
AU - Alam, M. I.
AU - Almoshari, Y.
AU - Bakkari, M. A.
AU - Sivadasan, D.
AU - Salawi, A.
AU - Jabeen, A.
AU - Ahsan, W.
DO - 10.3390/molecules27061796
IS - 6
KW - caraway oil
methylcellulose
vegetable oil
chemistry
emulsion
health
LA - English
PY - 2022
SN - 1420-3049
ST - Development and Optimization of Methylcellulose-Based Nanoemulgel Loaded with
Nigella sativa Oil for Oral Health Management: Quadratic Model Approach
T2 - Molecules
TI - Development and Optimization of Methylcellulose-Based Nanoemulgel Loaded with
Nigella sativa Oil for Oral Health Management: Quadratic Model Approach
VL - 27
ID - 13263
ER -
TY - JOUR
AB - Toothpasteis the paste or gel dentifrice used with a tooth-brush to clean and
maintain aesthetics and health of teeth. It is used to maintain or promote oral
hygiene, since last ten years there has been a booming demand for aesthetic
dentistry, consequently the bleaching and whitening products have made effective
augmenting cosmetic,so a routinely used product and its efficiency in whitening
play a major role in aesthetics.Toothpastes are complex mixtures of abrasives,
surfactants, anti-carrier agents such as fluorides, tartar control ingredients, pH
buffers, humectants to prevent drying out and increase the pleasant feeling in the
mouth, binders to provide consistency and shape. Tooth sensitivity is a common
problem that effects many people commonly, it involves experiencing pain or
discomfort to teeth from hot drinks, cold drinks or ice creams,andalso from sweets.
Bleeding gums is a sign that plaque has buildup where the teeth meet the gums, a
condition that can leads to gingivitis and periodontitis.Potassium nitrate in
toothpaste works by calming the nerves in the teeth.They desensitize nerves in
tooth pulp. Formulations containing 5% potassium nitrate (KNO3) is clinically
proven to reduce dentin hypersensitivity. Potassium ions travel into exposed dentin
tubules from the tooth surface to reach internal nerves.
AN - rayyan-563559981
AU - Sultana, A.
AU - Joysuwal, R.
AU - Nikhita, A.
AU - Rajeshwari, R.
AU - Fathima, A.
AU - Kadam, A.
IS - 3
chlorhexidine gluoconate
hydrogen peroxide
mouthwash
potassium nitrate
toothpaste
unclassified drug
aging
article
bruxism
classification
dental caries
drug formulation
enamel
gene
gingiva bleeding
gingivitis
human
laser therapy
malignant neoplasm
pathogenesis
periodontal disease
pregnancy
prophylaxis
smoking
tooth brushing
tooth discoloration
tooth plaque
tooth root
vitamin K deficiency
LA - English
PY - 2021
SN - 2230-7346
SP - 9672-9679
ST - A review on potassium nitrate, chlorhexidine gluoconate and hydrogen peroxide
toothpaste formulation to treatsensitivity, bleeding gums & whitening of teeth
T2 - J. Global Trends Pharm. Sci.
TI - A review on potassium nitrate, chlorhexidine gluoconate and hydrogen peroxide
toothpaste formulation to treatsensitivity, bleeding gums & whitening of teeth
VL - 12
ID - 13355
ER -
TY - JOUR
AB - Objectives: The object of this prospective study was to assess the submucosal
microbiome shifts in diseased peri-implant sites after non-surgical mechanical
debridement therapy. Materials and methods: Submucosal plaques were collected from
14 healthy implants and 42 diseased implants before and eight weeks after treatment
in this prospective study. Mechanical debridement was performed using titanium
curettes, followed by irrigation with 0.2% (w/v) chlorhexidine. Subsequently, 16S
rRNA gene sequencing was used to analyze the changes in the submucosal microbiome
before and after the non-surgical treatment. Results: Clinical parameters and the
submucosal microbiome were statistically comparable before and after mechanical
debridement. The Alpha diversity decreased significantly after mechanical
debridement. However, the microbial richness varied between the post-treatment and
healthy groups. In network analysis, the post-treatment increased the complexity of
the network compared to pre-treatment. The relative abundances of some pathogenic
species, such as Porphyromonas gingivalis, Tannerella forsythia,
Peptostreptococcaceae XIG-6 nodatum, Filifactor alocis, Porphyromonas endodontalis,
TM7 sp., and Desulfobulbus sp. HMT 041, decreased significantly following the non-
surgical treatment. Conclusions: Non-surgical treatment for peri-implant diseases
using mechanical debridement could provide clinical and microbiological benefits.
The microbial community profile tended to shift towards a healthy profile, and
submucosal dysbiosis was relieved following mechanical debridement.
AN - rayyan-563559755
AU - Sun, F.
AU - Wei, Y.
AU - Li, S.
AU - Nie, Y.
AU - Wang, C.
AU - Hu, W.
DO - 10.3389/fcimb.2022.1091938
KW - ChiCTR2000031392
curette
genetic analyzer
Gracey curette
Illumina MiSeq
spectrophotometer
tooth implant
chlorhexidine
RNA 16S
titanium
Actinobacteria
adult
article
Bacteroidetes
biofilm
bioinformatics
clinical article
clinical outcome
controlled study
Desulfobulbus
DNA extraction
dysbiosis
female
Firmicutes
Fusobacteria
gene sequence
human
illumina sequencing
Kolmogorov Smirnov test
lavage
male
microbial community
microbial diversity
microbial interaction
microbiome
middle aged
mouth hygiene
network analysis
Peptostreptococcaceae
periimplant microbiome
periimplantitis
phenotype
plaque index
prevalence
prospective study
radiography
Shannon index
species richness
spirochete
submucosal microbiome
GeneAmp 9700
NanoDrop 2000
QIAamp DNA Mini
LA - English
PY - 2023
SN - 2235-2988
ST - Shift in the submucosal microbiome of diseased peri-implant sites after non-
surgical mechanical debridement treatment
TI - Shift in the submucosal microbiome of diseased peri-implant sites after non-
surgical mechanical debridement treatment
VL - 12
ID - 13129
ER -
TY - JOUR
AB - Hyperlipidemia refers to the abnormal increase in plasma lipid level
exceeding the normal range. At present, a large number of patients require dental
implantation. However, hyperlipidemia affects bone metabolism, promotes bone loss,
and inhibits the osseointegration of dental implants through the mutual regulation
of adipocytes, osteoblasts, and osteoclasts. This review summarized the effects of
hyperlipidemia on dental implants and addressed the potential strategies of dental
implants to promote osseointegration in a hyperlipidemic environment and to improve
the success rate of dental implants in patients with hyperlipidemia. We summarized
topical drug delivery methods to solve the interference of hyperlipidemia in
osseointegration, which were local drug injection, implant surface modification and
bone-grafting material modification. Statins are the most effective drugs in the
treatment of hyperlipidemia, and they also encourage bone formation. Statins have
been used in these three methods and have been found to be positive in promoting
osseointegration. Directly coating simvastatin on the rough surface of the implant
can effectively promote osseointegration of the implant in a hyperlipidemic
environment. However, the delivery method of this drug is not efficient. Recently,
a variety of efficient methods of simvastatin delivery, such as hydrogels and
nanoparticles, have been developed to boost bone formation, but few of them were
applied to dental implants. Applicating these drug delivery systems using the three
aforementioned ways, according to the mechanical and biological properties of
materials, could be promising ways to promote osseointegration under hyperlipidemic
conditions. However, more research is needed to confirm.
AN - rayyan-563559728
AU - Sun, H.
AU - Meng, S.
AU - Chen, J.
AU - Wan, Q.
DO - 10.3390/jfb14040194
IS - 4
KW - tooth implant
hydrogel
interleukin 1
interleukin 6
nanoparticle
osteocalcin
simvastatin
statin (protein)
titanium
triacylglycerol
vasculotropin
bone density
bone graft
bone tissue
canonical Wnt signaling
human
hyperlipidemia
inflammation
microenvironment
osseointegration
ossification
osteoblast
oxidative stress
periodontitis
review
tissue regeneration
tooth implantation
LA - English
PY - 2023
SN - 2079-4983
ST - Effects of Hyperlipidemia on Osseointegration of Dental Implants and Its
Strategies
TI - Effects of Hyperlipidemia on Osseointegration of Dental Implants and Its
Strategies
VL - 14
ID - 13102
ER -
TY - JOUR
AB - Subgingival plaque samples and root canal samples were collected from 2,839
marginal periodontitis (MP) patients and 21 apical periodontitis (AP) patients.
Enterococcus species were identified by a series of phenotypic and genotypic tests.
Antimicrobial susceptibility assays were performed by an agar disk diffusion test.
Multilocus sequence typing (MLST), eBURST, and minimum spanning tree were used for
enterococcal genetic clustering and population analysis. Enterococcus faecalis was
recovered from 3.7% MP patients and 9.5% AP patients, and Enterococcus faecium was
recovered from 0.04% MP patients. Enterococci were detected more often in older
male patients. E. faecalis isolates of MP were found resistant to tetracycline
(49.1%), erythromycin (8.5%), trimethoprim (2.8%), and gentamicin (1.9%), while one
AP isolate was resistant to tetracycline. A total of 40 sequence types (STs) were
resolved in 108 E. faecalis isolates. Comparison with E. faecalis international
MLST database revealed that 27 STs were previously found, 13 STs were novel, and
several major clonal complexes in the database were also found in MP isolates. The
tetracycline-resistant isolates distributed mainly in the major clonal complexes
and singletons, whereas the erythromycin-resistant isolates were more dispersed.
Although the rate of occurrence of enterococci recovered in the MP and AP samples
was low, 50% of these isolates are resistant to at least one antimicrobial agent,
which is most often tetracycline. This implies that subgingival E. faecalis might
represent a reservoir of resistance to tetracycline and erythromycin. The
subgingival E. faecalis isolates show high genetic diversity but are grouped, in
general, with the known isolates from the international database.
AN - rayyan-563562370
AU - Sun, J. L.
AU - Song, X. B.
AU - Kristiansen, B. E.
AU - Kjaereng, A.
AU - Willems, R. J. L.
AU - Eriksen, H. M.
AU - Sundsfjord, A.
AU - Sollid, J. E.
DO - 10.1128/JCM.00388-09
IS - 7
PY - 2009
SN - ["0095-1137", "1098-660X"]
SP - 2218-2225
ST - Occurrence, Population Structure, and Antimicrobial Resistance of Enterococci
in Marginal and Apical Periodontitis
T2 - JOURNAL OF CLINICAL MICROBIOLOGY
TI - Occurrence, Population Structure, and Antimicrobial Resistance of Enterococci
in Marginal and Apical Periodontitis
VL - 47
Y2 - 7
ID - 15744
ER -
TY - JOUR
AB - Matrix metalloproteinases (MMPs) play a key role in periodontal disease.
Although it is known that macrophages and fibroblasts are co-localized and express
MMPs in the diseased periodontal tissue, the effect of interaction between these
two cell types on MMP expression has not been well elucidated. Furthermore although
it is known that diabetes is associated with accelerated periodontal tissue
destruction, it remains unknown whether hyperglycemia, a major metabolic
abnormality in diabetes, regulates MMP expression by affecting the cross-talking
between fibroblasts and macrophages. In this study, human gingival fibroblasts and
U937 macrophages were cocultured in a two-compartment transwell culture system, and
the cells were treated with normal or high glucose.Wefound that coculture of
fibroblasts and U937 macrophages led to an augmentation of MMP-1 expression by U937
macrophages, and high glucose further enhanced this augmentation. Similar
observations were also made in the coculture of fibroblasts and human primary
monocytes. We also found that interleukin 6 (IL-6) released by fibroblasts was
essential for the augmentation of MMP-1 expression by U937 macrophages. Furthermore
our results showed that high glucose, IL-6, and lipopolysaccharide had a
synergistic effect on MMP-1 expression. Finally our study indicated that MAPK
pathways and activator protein-1 transcription factor were involved in the
coculture- and high glucose-augmented MMP-1 expression. In conclusion, this study
demonstrates that IL-6 derived from fibroblasts is essential for MMP-1 up-
regulation by cross-talking between fibroblasts and U937 macrophages exposed to
high glucose, revealing an IL-6-dependent mechanism in MMP-1 up-regulation.
AN - rayyan-563560678
AU - Sundararaj, K. P.
AU - Samuvel, D. J.
AU - Li, Y.
AU - Sanders, J. J.
AU - Lopes-Virella, M. F.
AU - Huang, Y.
DO - 10.1074/jbc.M806573200
IS - 20
KW - collagenase 3
gelatinase A
glucose
interleukin 6
lipopolysaccharide
article
cell culture
cell interaction
U-937 cell line
coculture
controlled study
cytokine release
diabetes mellitus
enzyme release
fibroblast
gingiva
histiocyte
human
human cell
macrophage
monocyte
nucleotide sequence
periodontal disease
priority journal
protein expression
upregulation
LA - English
PY - 2009
SN - ["0021-9258", "1083-351X"]
SP - 13714-13724
ST - Interleukin-6 released from fibroblasts is essential for up-regulation of
matrix metalloproteinase-1 expression by U937 macrophages in coculture: Cross-
talking between fibroblasts and U937 macrophages exposed to high glucose
T2 - J. Biol. Chem.
TI - Interleukin-6 released from fibroblasts is essential for up-regulation of
matrix metalloproteinase-1 expression by U937 macrophages in coculture: Cross-
talking between fibroblasts and U937 macrophages exposed to high glucose
VL - 284
ID - 14052
ER -
TY - JOUR
AB - Periodontal disease is a common disease in the oral field, and many
researchers are studying periodontal disease and try to find some biological
scaffold materials to make periodontal tissue regenerative. In this study, we
attempted to construct a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL)
ternary composite hydrogel and then prepare porous scaffold by 3D printing
technology. Subsequently, characterizing the materials and testing the mechanical
properties of the scaffold. Additionally, its effect on the proliferation of human
periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas
gingivalis were detected. We found that CNT/CS/AL porous composite scaffolds with
uniform pores could be successfully prepared. Moreover, with increasing CNT
concentration, the degradation rate and the swelling degree of scaffold showed a
downward trend. The compressive strength test indicated the elastic modulus of
composite scaffolds ranged from 18 to 80 kPa, and 1% CNT/CS/AL group had the
highest quantitative value. Subsequently, cell experiments showed that the
CNT/CS/AL scaffold had good biocompatibility and could promote the proliferation of
hPDLCs. Among 0.1%-1% CNT/CS/AL groups, the biocompatibility of 0.5% CNT/CS/AL
scaffold performed best. Meanwhile, in vitro antibacterial experiments showed that
the CNT/CS/AL scaffold had a certain bacteriostatic effect on P. gingivalis. When
the concentration of CNT was more than 0.5%, the antimicrobial activity of
composite scaffold was significantly promoted, and about 30% bacteria were
inactivated. In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good
material properties, biocompatibility and bacteriostatic activity, may be used for
periodontal tissue regeneration, providing a new avenue for the treatment of
AN - rayyan-563562409
AU - Suo, L.
AU - Wu, H. S.
AU - Wang, P. Y.
AU - Xue, Z. J.
AU - Gao, J.
AU - Shen, J.
DO - 10.1002/jbm.b.35133
IS - 1
PY - 2023
SN - ["1552-4973", "1552-4981"]
SP - 73-84
ST - The improvement of periodontal tissue regeneration using a 3D-printed carbon
nanotube/chitosan/sodium alginate composite scaffold
TI - The improvement of periodontal tissue regeneration using a 3D-printed carbon
VL - 111
Y2 - 1
ID - 15783
ER -
TY - JOUR
AB - Periodontal disease is a common disease in the oral field, and many
researchers are studying periodontal disease and try to find some biological
scaffold materials to make periodontal tissue regenerative. In this study, we
attempted to construct a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL)
ternary composite hydrogel and then prepare porous scaffold by 3D printing
technology. Subsequently, characterizing the materials and testing the mechanical
properties of the scaffold. Additionally, its effect on the proliferation of human
periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas
gingivalis were detected. We found that CNT/CS/AL porous composite scaffolds with
uniform pores could be successfully prepared. Moreover, with increasing CNT
concentration, the degradation rate and the swelling degree of scaffold showed a
downward trend. The compressive strength test indicated the elastic modulus of
composite scaffolds ranged from 18 to 80 kPa, and 1% CNT/CS/AL group had the
highest quantitative value. Subsequently, cell experiments showed that the
CNT/CS/AL scaffold had good biocompatibility and could promote the proliferation of
hPDLCs. Among 0.1%–1% CNT/CS/AL groups, the biocompatibility of 0.5% CNT/CS/AL
scaffold performed best. Meanwhile, in vitro antibacterial experiments showed that
the CNT/CS/AL scaffold had a certain bacteriostatic effect on P. gingivalis. When
the concentration of CNT was more than 0.5%, the antimicrobial activity of
composite scaffold was significantly promoted, and about 30% bacteria were
inactivated. In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good
material properties, biocompatibility and bacteriostatic activity, may be used for
periodontal tissue regeneration, providing a new avenue for the treatment of
AN - rayyan-563559757
AU - Suo, L.
AU - Wu, H.
AU - Wang, P.
AU - Xue, Z.
AU - Gao, J.
AU - Shen, J.
DO - 10.1002/jbm.b.35133
IS - 1
KW - 3D Drawing Software
imaging software
tissue scaffold
alginic acid
antiinfective agent
carbon nanotube
chitosan
hydrogel
nanocomposite
viscoelastic substance
adolescent
adult
article
biocompatibility
cell culture
cell proliferation
cell structure
cell viability
child
controlled study
degradation
human
human cell
in vitro study
nanofabrication
nonhuman
periodontium
porosity
surface property
tissue regeneration
X ray diffraction
young adult
Young modulus
LA - English
PY - 2023
SN - ["1552-4981", "1552-4973"]
SP - 73-84
ST - The improvement of periodontal tissue regeneration using a 3D-printed carbon
TI - The improvement of periodontal tissue regeneration using a 3D-printed carbon
VL - 111
ID - 13131
ER -
TY - JOUR
AB - Background: The antimicrobial peptide LL-37 is known to have a potent
lipopolysaccharide (LPS)-neutralizing activity in various cell types. Because of
observed heterogeneity within periodontopathogenic LPS, the authors hypothesized
that LL-37 had specificity to neutralize such LPS activity. The present study,
therefore, aims to investigate the LPSneutralizing activity of LL-37 to various
periodontopathogenic LPS in interleukin-8 (IL-8) production after challenging them
in human oral fibroblasts. Methods: Human periodontal ligament fibroblasts (PDLF)
and gingival fibroblasts (GF) were cultured from biopsies of periodontal ligament
and gingival tissues. After cell confluence in 24-well plates, LPS (10 μg/mL) from
Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, and
Aggregatibacter actinomycetemcomitans were added with or without LL-37 (10 μg/mL).
After 18 hours, the supernatant was collected and analyzed in IL-8 production by
enzyme-linked immunosorbent assay. Results: All periodontopathogenic LPS
statistically significantly induced IL-8 production in both PDLF and GF (P <0.01).
After neutralization with LL-37, both PDLF and GF showed a statistically
significant reduction in IL-8 production compared with LPS-treated groups without
LL-37 (P <0.01), and the percentage of reduction in IL-8 production in PDLF
appeared to be higher than in GF. In addition, the percentage of reduction in IL-8
production varied considerably according to each periodontopathogenic LPS.
Conclusions: The antimicrobial peptide LL-37 had an ability to suppress
periodontopathogenic LPS-induced IL-8 production in both PDLF and GF. Its LPS-
neutralizing activity revealed specificity to periodontopathogenic LPS and seemed
to be dependent on the heterogeneity within LPS between different genera. © 2013
American Academy of Periodontology.
AN - rayyan-563560498
AU - Suphasiriroj, W.
AU - Mikami, M.
AU - Shimomura, H.
AU - Sato, S.
DO - 10.1902/jop.2012.110652
IS - 2
CAP18 lipopolysaccharide binding protein
CAP18 lipopolysaccharide-binding protein
interleukin 8
lipopolysaccharide
lipopolysaccharide, Escherichia coli 0111 B4
adult
article
cell culture
comparative study
cytology
drug antagonism
drug effect
Escherichia coli
fibroblast
gingiva
human
Limulus lysate test
microbiology
periodontal disease
physiology
species difference
LA - English
PY - 2013
SN - 0022-3492
SP - 256-264
ST - Specificity of antimicrobial peptide LL-37 to neutralize periodontopathogenic
lipopolysaccharide activity in human oral fibroblasts
TI - Specificity of antimicrobial peptide LL-37 to neutralize periodontopathogenic
VL - 84
ID - 13872
ER -
TY - COMP
AB - BACKGROUND: The antimicrobial peptide LL-37 is known to have a potent
lipopolysaccharide (LPS)-neutralizing activity in various cell types. Because of
observed heterogeneity within periodontopathogenic LPS, the authors hypothesized
that LL-37 had specificity to neutralize such LPS activity. The present study,
therefore, aims to investigate the LPS-neutralizing activity of LL-37 to various
periodontopathogenic LPS in interleukin-8 (IL-8) production after challenging them
in human oral fibroblasts. METHODS: Human periodontal ligament fibroblasts (PDLF)
and gingival fibroblasts (GF) were cultured from biopsies of periodontal ligament
and gingival tissues. After cell confluence in 24-well plates, LPS (10 μg/mL) from
Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, and
Aggregatibacter actinomycetemcomitans were added with or without LL-37 (10 μg/mL).
After 18 hours, the supernatant was collected and analyzed in IL-8 production by
enzyme-linked immunosorbent assay. RESULTS: All periodontopathogenic LPS
statistically significantly induced IL-8 production in both PDLF and GF (P <0.01).
After neutralization with LL-37, both PDLF and GF showed a statistically
significant reduction in IL-8 production compared with LPS-treated groups without
LL-37 (P <0.01), and the percentage of reduction in IL-8 production in PDLF
appeared to be higher than in GF. In addition, the percentage of reduction in IL-8
production varied considerably according to each periodontopathogenic LPS.
CONCLUSIONS: The antimicrobial peptide LL-37 had an ability to suppress
periodontopathogenic LPS-induced IL-8 production in both PDLF and GF. Its LPS-
neutralizing activity revealed specificity to periodontopathogenic LPS and seemed
to be dependent on the heterogeneity within LPS between different genera.
AN - rayyan-563561368
AU - Suphasiriroj, W.
AU - Mikami, M.
AU - Shimomura, H.
AU - Sato, S.
CY - United States
DO - 10.1902/jop.2012.110652
ET - 2
J2 - J Periodontol
KW - Adult
Aggregatibacter actinomycetemcomitans/physiology
Antimicrobial Cationic Peptides/*pharmacology
Cells, Cultured
Escherichia coli/physiology
Fibroblasts/*drug effects
Fusobacterium nucleatum/physiology
Gingiva/cytology/*drug effects
Humans
Interleukin-8/antagonists & inhibitors
Limulus Test
Lipopolysaccharides/analysis/*antagonists & inhibitors
Periodontal Diseases/*microbiology
Periodontal Ligament/cytology/*drug effects
Porphyromonas gingivalis/physiology
Prevotella intermedia/physiology
Species Specificity
Young Adult
Cathelicidins
LA - eng
N1 - Department of Periodontology, The Nippon Dental University, School of Life
Dentistry at Niigata, Chuo-ku, Niigata, Japan. bukung@ngt.ndu.ac.jp
PY - 2013
SP - 256-64
ST - Specificity of antimicrobial peptide LL-37 to neutralize periodontopathogenic
TI - Specificity of antimicrobial peptide LL-37 to neutralize periodontopathogenic
VL - 84
Y2 - 2
ID - 14742
ER -
TY - JOUR
AB - CONCLUSION: Chlorhexidine gel can be successfully formulated and will inhibit
plaque growth to some degree, but not to the same extent, as a CHX MW. When CHX
DF/gel is used in a non-brushing model, it is significantly less effective in
plaque inhibition compared to CHX MW. Based on one study when CHX gel was applied
with a finger after brushing, it is significantly more effective on plaque scores
and the gingival index. The only brushing study also with a long follow-up showed
that there is no significant difference between CHX DF and CHX MW. However, as a
corollary, significantly more tooth discoloration was observed with the CHX MW.
Altogether, the data show that when daily oral hygiene cannot be performed, CHX MW
is the first product of choice. OBJECTIVE: To systematically review and evaluate
the available scientific evidence on the effectiveness of chlorhexidine dentifrice
or gel (CHX DF/gel) compared to chlorhexidine mouthwash (CHX MW) on plaque,
bleeding, gingival inflammation and tooth discoloration scores. MATERIAL AND
METHODS: PubMed-MEDLINE, Cochrane-CENTRAL and EMBASE databases were searched to
identify appropriate studies. RESULTS: Independent screening of the 2256 unique
titles and abstracts resulted in five publications that met the eligibility
criteria. Considerable heterogeneity was found between the studies. Three of the
five studies showed a positive effect on plaque scores in favour of the CHX MW.
With respect to gingival index and bleeding scores, no significant differences were
found. Chlorhexidine mouthwash, however, showed a significantly more tooth
discoloration than the CHX DF/gel. A meta-analysis of the effect on 'de novo'
plaque formation of CHX DF/gel versus CHX MW resulted in a difference in means of
0.27 [95% CI: 0.14; 0.39] (P < 0.0001).
AN - rayyan-563560384
AU - Supranoto, S. C.
AU - Slot, D. E.
AU - Addy, M.
AU - Van der Weijden, G. A.
DO - 10.1111/idh.12078
IS - 2
KW - chlorhexidine
gel
mouthwash
toothpaste
chemically induced
comparative study
tooth plaque
gingiva bleeding
gingivitis
human
periodontics
tooth discoloration
LA - English
PY - 2015
SN - 1601-5037
SP - 83-92
ST - The effect of chlorhexidine dentifrice or gel versus chlorhexidine mouthwash
on plaque, gingivitis, bleeding and tooth discoloration: a systematic review
T2 - Int J Dent Hyg
TI - The effect of chlorhexidine dentifrice or gel versus chlorhexidine mouthwash
on plaque, gingivitis, bleeding and tooth discoloration: a systematic review
VL - 13
ID - 13758
ER -
TY - JOUR
AB - In recent years, the novel mucoadhesive buccal drug delivery system has been
developed over the conventional and systemic dosage forms. To bypass drugs from the
hepatic first-pass metabolism and it enhances the bioavailability of drug at the
site of administration. Absorption of a drug through the buccal mucosa reduces the
degradation. Some of the enzyme activity and pH variation in the gastrointestinal
tract reduces the absorption and active drug loss. To overcome this problem, the
buccal route is preferred. Polymers are used in this formulation to improve the
drug release rate over an extended period, and also, the therapeutic plasma level
of the drug can be rapidly achieved. Overall this narrative review explains
mechanism and theories, method of preparation, factors affecting mucoadhesion,
advantages and limitations, applications, components used in the formulation,
characterization and evaluation methods. Since the cytoplasm and intercellular
spaces are hydrophilic. Lipophilic drugs have a low solubility in this environment.
However, the cell membrane is rather lipophilic; it tends to difficulty permeating
the hydrophilic solute through the cell membrane because of a low partition
coefficient. Therefore, the cytoplasm and intercellular spaces act as a major
barrier to penetration of lipophilic compounds and the cell membrane poses as an
extensive transport barrier for hydrophilic compounds. Since the oral epithelial is
stratified, the permeation of solute may involve these combination routes so that
the route is more predictable.
AN - rayyan-563560062
AU - Suresh Babu, P.
AU - Amarendra, M.
AU - Subha, V. J.
AU - Senthamarai, S.
DO - 10.26452/ijrps.v11iSPL4.3780
KW - nasal drug delivery system
carbomer
castor oil
ciprofloxacin
clotrimazole
gel
metronidazole
polymer
polyvinyl alcohol
adult
article
bioavailability
buccal mucosa
cell membrane
child
controlled study
crystallization
drug dosage form
drug elimination
drug formulation
drug granulation
drug industry
drug release
drug solubility
drug stability
drug synthesis
dry eye
enzyme activity
first pass effect
human
human tissue
hydrogen bond
hydrophilicity
immunization
intercellular space
lipophilicity
liver
melting point
moisture
mucoadhesion
narrative
nausea and vomiting
nose mucosa
partition coefficient
periodontal disease
pH
pharmacokinetics
physical chemistry
solute
tablet hardness
tablet property
tensile strength
vaginal delivery
viscosity
vomiting
X ray diffraction
LA - English
PY - 2020
SN - 0975-7538
SP - 252-258
ST - An analytical assessment on mucoadhesive buccal drug delivery system for
improving patient convenience and compliance
TI - An analytical assessment on mucoadhesive buccal drug delivery system for
improving patient convenience and compliance
VL - 11
ID - 13436
ER -
TY - JOUR
AB - This study compared the anti-inflammatory efficacy of Triclosan and
Flurbiprofen in a gel form on clinical parameters of moderate gingivitis cases. The
study comprised of 100 sites from 16 volunteers and used split mouth technique.
0.3% Triclosan/0.3% Flurbiprofen gels applied intracrevicularly once daily for one
week. Clinical parameters like Plaque index, Gingival index and Bleeding index
scores were recorded at 0 day, 4th day and 8th day. The obtained results showed
significant reductions in clinical parameters from baseline to 8th day. This
indicates local delivery of 0.3% Triclosan/0.3% Flurbiprofen gel can be used as an
anti-inflammatory agents either alone or as an adjunct to scaling in periodontal
therapy.
AN - rayyan-563560923
AU - Suresh, D. K.
AU - Vandana, K. L.
AU - Mehta, D. S.
IS - 2
KW - flurbiprofen
triclosan
adolescent
adult
article
clinical trial
comparative study
controlled study
female
gel
gingiva
gingivitis
human
injection
male
periodontics
tooth plaque
LA - English
PY - 2001
SN - 0970-9290
SP - 105-112
ST - Intracrevicular application of 0.3% Flurbiprofen gel and 0.3% Triclosan gel
as anti inflammatory agent. A comparative clinical study
TI - Intracrevicular application of 0.3% Flurbiprofen gel and 0.3% Triclosan gel
as anti inflammatory agent. A comparative clinical study
VL - 12
ID - 14297
ER -
TY - JOUR
AB - The aim of the present work was to investigate the potential of cubic phase
gel based drug delivery system for periodontal delivery of ciprofloxacin. The
prepared gels were characterized for drug content, drug loading efficiency,
gelation temperature, gel melting temperature, pH, bioadhesive force, viscosity,
gel strength, swelling and drug release profile. The cubic phase gels were prepared
with varying combinations of glyceryl monooleate(GMO), glyceryl monostearate (GMS),
methyl cellulose, Span 80, propylene glycol, polyethylene glycol and glycerol. The
drug content in the formulations was found to be high and in the range of 89.91-
96.44%. All the formulations displayed the gelation temperature within the
appropriate range of 30-36°C. C-2 had the highest gelation temperature, gel melting
temperature, viscosity and mucoadhesive strength. The surface pH of gels was found
in the range of 6.41-6.78 and gel strength from 60-75s. The drug release kinetic
studies divulged the best fit with the Higuchi's equation, representing the release
of ciprofloxacin HCl by diffusion.
AN - rayyan-563560525
AU - Suresh, P. K.
AU - Dewangan, M. K.
IS - 4
KW - ciprofloxacin
glycerol oleate
glycerol stearate
macrogol
methylcellulose
propylene glycol
sorbitan oleate
drug formulation
drug research
drug synthesis
gel
gelation
melting point
review
surface property
viscosity
LA - English
PY - 2012
SN - 0975-8585
SP - 869-877
ST - Ciprofloxacin HCl loaded cubic phase gel for periodontal intrapocket
administration
TI - Ciprofloxacin HCl loaded cubic phase gel for periodontal intrapocket
administration
VL - 3
ID - 13899
ER -
TY - JOUR
AB - Periodontitis is a chronic inflammatory disease of the gums caused by
pathogenic microorganisms damaging and destroying periodontal tissues.
Chlorhexidine digluconate (CHX) is a commonly used antimicrobial agent for the
treatment of periodontitis. However, it has many drawbacks, such as toxicity due to
the high dosage required, low prolonged release, and low adhesion in the
periodontal pocket. The objective of this study was to develop and optimize CHX-
encapsulated polymeric nanoparticles (NPs) loaded into in situ gel-forming (ISGF)
using design of experiment (DoE) to improve the treatment of periodontitis and
overcome these limitations. CHX-NPs were optimized from 0.046%w/v chitosan,
0.05%w/w gelatin, and 0.25%w/w CHX. After that, the optimized of CHX-NPs was loaded
into a thermosensitive ISGF, which was a mixture of 15%w/v Poloxamer 407 and 1%
hydroxypropyl methylcellulose (HPMC). The optimized CHX-NPs, loaded into ISGF, was
evaluated by measuring gelling temperature and time, pH, viscosity, compatibility,
in vitro drug release, antibacterial activity, cytotoxicity, and stability. The
results showed that the size, PDI, and zeta potential of optimized CHX-NPs were
53.07±10.17 nm, 0.36±0.02, and 27.63±4.16 mV, respectively. Moreover, the optimized
ISGF loading CHX-NPs showed a gelling temperature at 34.3±1.2°C within 120.00±17.32
s with a pH value of 4.06. The viscosity of the formulations at 4°C was 54.33±0.99
cP. The DSC and FTIR showed no interaction between ingredients. The optimal
formulations showed a prolonged release of up to 7 days while providing potential
antibacterial activity and were safe for normal gingival fibroblast cells.
Moreover, the formulations had high stability at 4°C and 25°C for 3 months. In
conclusion, the study achieved the successful development of ISGF loading CHX-NPs
formulations for effectiveness use in periodontal treatment. Graphical Abstract:
[Figure not available: see fulltext.].
AN - rayyan-563559687
AU - Suriyaamporn, P.
AU - Sahatsapan, N.
AU - Patrojanasophon, P.
AU - Opanasopit, P.
AU - Kumpugdee-Vollrath, M.
AU - Ngawhirunpat, T.
DO - 10.1208/s12249-023-02600-0
IS - 6
KW - antibacterial activity
article
controlled study
cytotoxicity
drug formulation
drug release
experimental design
fibroblast
gingiva
human
in vitro study
periodontitis
pH
viscosity
zeta potential
chlorhexidine
endogenous compound
gelatin
poloxamer
protein disulfide isomerase
LA - English
PY - 2023
SN - 1530-9932
ST - Optimization of In Situ Gel-Forming Chlorhexidine-Encapsulated Polymeric
Nanoparticles Using Design of Experiment for Periodontitis
TI - Optimization of In Situ Gel-Forming Chlorhexidine-Encapsulated Polymeric
Nanoparticles Using Design of Experiment for Periodontitis
VL - 24
ID - 13061
ER -
TY - JOUR
AB - Bleaching agents containing a high concentration of H2O2 in the dental market
lead to formation of reactive oxygen species, which have genotoxic effects.
However, ozone bleaching, one of the most effective oxidants known, stimulates
blood circulation and immune response and thus it has strong antimicrobial activity
against viruses, bacteria, fungi, and protozoa. For these reasons, one of our
hypothesis was ozone bleaching would reduce local and systemic DNA damage in the
body. Hence, we aimed to determine the oxidative DNA damage biomarker levels in
serum, saliva, and gingival crevicular fluid (GCF) by measuring 8-hydroxy-2′-
deoxyguanosine (8-OHdG) after different bleaching methods. Forty-eight volunteers
who requested dental bleaching were divided into three treatment groups (n = 16).
Group 1: ozone bleaching with the ozone-releasing machine; Group 2: chemical
bleaching with 40% hydrogen peroxide (H2O2) gel; Group 3: 40% H2O2 gel activated
with the diode laser. Initial and post-operative (immediately after bleaching and
two weeks later) color measurements were performed with a spectrophotometer. The
color changes were calculated with the CIEDE2000 (ΔE00) formula. 8-OHdG levels in
serum, saliva, and GCF samples were determined with ELISA. All three treatments
resulted in efficient and statistically similar bleaching. The 8-OHdG levels in the
serum and saliva were not affected by all bleaching methods (p > 0.05), but a
temporary increase was observed in the GCF for chemical and laser-assisted groups
except the ozone group (p > 0.05). According to the findings, chemical and laser-
assisted bleaching can affect DNA damage locally but not systemically. Bleaching
with ozone may eliminate this local DNA damage.
AN - rayyan-563559975
AU - Sürmelioğlu, D.
AU - Gündoğar, H.
AU - Taysi, S.
AU - Bağiş, Y. H.
DO - 10.1177/0960327121996030
IS - 8
KW - diode laser
spectrophotometer
8 hydroxydeoxyguanosine
bleaching agent
adult
article
blood level
clinical article
dental procedure
DNA damage
gingivitis
human
saliva level
LA - English
PY - 2021
SN - ["1477-0903", "0960-3271"]
SP - 1332-1341
ST - Effect of different bleaching techniques on DNA damage biomarkers in serum,
saliva, and GCF
T2 - Hum. Exp. Toxicol.
TI - Effect of different bleaching techniques on DNA damage biomarkers in serum,
saliva, and GCF
VL - 40
ID - 13349
ER -
TY - JOUR
AB - Periodontitis is one of the most widespread oral diseases. Medicated in-situ
gels of Moxifloxacin Hydrochloride for extended period of retention in infected
cavity were prepared for improved local action for the treatment of periodontitis.
Medicated formulations were prepared using temperature sensitive (poloxamer 407),
ion sensitive (gellan gum) and pH sensitive (carbopol 934P) polymers. 32 Full
Factorial Design has been applied and prepared batches were characterized by FTIR,
pH, syringeability, drug content, clarity, gelation temperature, gelling time, in-
vitro gelling capacity, in-vitro diffusion study. Gelation temperature, (in-vitro)
gelling time and the nature of gel formed in simulated saliva showed polymeric
concentration dependency. Diffusion study of in-situ gel had been performed which
showed augmented arrival of medication from 7-12 hours and the discharge was
dependent on polymer utilized. The best fitted model was zero order kinetics which
indicated that the formulation gave controlled delivery. All preparations were non-
Newtonian and display pseudoplastic conduct. Invitro Antimicrobial study was
carried out by utilizing E. coli and S. aureus. Optimized formulation containing
19.072 %w/v poloxamer 407 and 0.245 %w/v gellan gum exhibited desired
characteristics for developing periodontal drug delivery systems.
AN - rayyan-563560957
AU - Swain, G. P.
AU - Patel, S.
AU - Gandhi, J.
AU - Shah, P.
DO - 10.1016/j.jobcr.2019.04.001
IS - 3
LA - eng
N1 - Department of Pharmaceutics, Maliba Pharmacy College, Bardoli Mahuva Road,
Dist. Surat, Gujarat, 394 350, India.; Department of Pharmaceutics, Maliba Pharmacy
College, Bardoli Mahuva Road, Dist. Surat, Gujarat, 394 350, India.; Department of
Pharmaceutics, Maliba Pharmacy College, Bardoli Mahuva Road, Dist. Surat, Gujarat,
394 350, India.; Department of Pharmaceutics, Maliba Pharmacy College, Bardoli
Mahuva Road, Dist. Surat, Gujarat, 394 350, India.
PY - 2019
SN - 2212-4268 (Print)
SP - 190-200
ST - Development of Moxifloxacin Hydrochloride loaded in-situ gel for the
treatment of periodontitis: In-vitro drug release study and antibacterial activity
TI - Development of Moxifloxacin Hydrochloride loaded in-situ gel for the
treatment of periodontitis: In-vitro drug release study and antibacterial activity
VL - 9
Y2 - 7
ID - 14331
ER -
TY - JOUR
AB - Background: Periodontal disease is an infectious, inflammatory disease
associated with overgrowth of certain pathogenic bacteria, release of bacterial
toxins and inflammatory response of the host. The management of human periodontitis
suggests therapies with Nutraceuticals, Surgical therapy and use of Antimicrobial
agents. Odonto-nutraceuticals may play a significant role in the care of dental
patients, with complex and multifactorial disorders, involving deregulated
pathways, like Periodontitis. The present article highlights the role of
nutraceuticals in the prevention of periodontal disease.
AN - rayyan-563560098
AU - Swaminatham, P. G.
AU - Ramesh, J. S.
AU - Viddyasagar, M.
AU - Amit, M.
AU - Priti, K.
AU - Neeta, P.
AU - Meghana, P.
DO - 10.36848/PMR/2020/13100.51330
IS - 3
ascorbic acid
calcium
carbon nanotube
cranberry extract
drug carrier
gel
liposome
magnesium
microsphere
nanocrystal
nanoparticle
nutraceutical
polyglactin
probiotic agent
resveratrol
retinol
vitamin B complex
vitamin D
bone regeneration
dental prevention
human
liposomal delivery
nanorobotics
nonhuman
periodontal disease
review
LA - English
PY - 2020
SN - ["0976-0164", "0975-0533"]
SP - 87-90
ST - Nutraceutical basis for drug delivery in periodontal disease
T2 - Pravara Med. Rev.
TI - Nutraceutical basis for drug delivery in periodontal disease
VL - 12
ID - 13472
ER -
TY - JOUR
AB - Prosthodontics practice involves contact with restorative materials,
auxiliary dental materials which are broadly of different composition. The leakage
and transfer of the potent allergic components from these materials is the cause of
hypersensitive reactions to patients, dental professionals and the lab technicians.
The biological side-effects of the materials that are in dental practice are rare.
All artificial materials release substances in the oral environment which are
potent allergens that might cause side effects and adverse reactions. The current
study gives a statically about the dental professional knowledge and also makes the
aware of toxic biological side effects of these materials, also make them aware of
the reporting of the cases. A cross sectional survey was conducted among 100 dental
professionals about the Toxic Biological effects associated with materials used in
prosthodontics. Questionnaires with 20 close ended questions were circulated among
people. Results obtained analyzed using SPSS software.In this Study, almost 80% of
them were aware that some components of the dental materials might cause a
hypersensitivity reaction. 57% of the participants have not experienced any
allergic resin, latex, gloves etc. The prevalence of allergic reaction among Dental
staff is low and most reported are due to latex, acrylate & formaldehyde. The
present study shows that there is a lack of knowledge on the toxic biological
effects of dental material used in prosthodontics.
AN - rayyan-563560085
AU - Swetha, G.
AU - Kommi, V.
AU - Keerthi Sasanka, L.
AU - Leslie Rani, S.
DO - 10.37506/ijfmt.v14i4.12527
IS - 4
KW - acrylic acid
acrylic acid resin
allergen
cadmium
dental material
formaldehyde
gel
latex
resin
adult
allergy
article
awareness
biocompatibility
biological activity
delayed hypersensitivity
dental practice
dental staff
dental student
dental technician
dentist
drug induced disease
female
gingivitis
health care personnel
human
incidence
male
occupational exposure
occupational hazard
prevalence
professional knowledge
prosthodontics
questionnaire
risk factor
side effect
LA - English
PY - 2020
SN - ["0973-9130", "0973-9122"]
SP - 5888-5898
ST - Toxic biological effects associated with materials used in prosthodontics-a
survey
TI - Toxic biological effects associated with materials used in prosthodontics-a
survey
VL - 14
ID - 13459
ER -
TY - JOUR
AN - rayyan-563561661
AU - Sy, K.
AU - Flamme, J.
AU - Macquet, H.
AU - Chai, F.
AU - Neut, C.
AU - Siepmann, F.
AU - Agossa, K.
IS - 6
PY - 2020
SP - 305-309
ST - Antimicrobial effect and physical properties of an injectable "active oxygen"
gel for the treatment of periodontitis
T2 - American Journal of Dentistry
TI - Antimicrobial effect and physical properties of an injectable "active oxygen"
85099894936&partnerID=40&md5=7a67f7487c9265159850a7503314c0db
VL - 33
ID - 15035
ER -
TY - JOUR
AB - Purpose: To evaluate an injectable gel, recently proposed for the controlled
release of "active oxygen" in periodontal pockets, compared to an antibiotic or an
antiseptic gel, respectively. Methods: The antimicrobial activity, injectability,
texture properties, swelling and water uptake of the gels were studied. Results:
The "active oxygen" gel showed a bactericidal effect comparable to the two
commercially available drug products (containing minocycline or chlorhexidine) on
anaerobic periodontal pathogens and did not seem to affect aerobic strains. The gel
was easy to inject and stable in an aqueous medium for several days. Texture
analysis revealed potential gel fragility.
AN - rayyan-563562214
AU - Sy, K.
AU - Flamme, J.
AU - Macquet, H.
AU - Chai, F.
AU - Nuet, C.
AU - Siepmann, F.
AU - Agossa, K.
IS - 6
PY - 2020
SN - 0894-8275
SP - 305-309
T2 - AMERICAN JOURNAL OF DENTISTRY
VL - 33
Y2 - 12
ID - 15588
ER -
TY - JOUR
AB - PURPOSE: To evaluate an injectable gel, recently proposed for the controlled
antiseptic gel, respectively. METHODS: The antimicrobial activity, injectability,
texture properties, swelling and water uptake of the gels were studied. RESULTS:
analysis revealed potential gel fragility. CLINICAL SIGNIFICANCE: The investigated
gel for local delivery of oxygen can help to selectively eradicate anaerobic
bacteria associated with periodontitis and promote the recovery of a healthy-
compatible oral flora.
AN - rayyan-563560798
AU - Sy, K.
AU - Flamme, J.
AU - Maquet, H.
AU - Chai, F.
AU - Neut, C.
AU - Siepmann, F.
AU - Agossa, K.
IS - 6
J2 - Am J Dent
KW - *Anti-Infective Agents, Local
Gels
Humans
Reactive Oxygen Species
LA - eng
N1 - Controlled Drug Delivery Systems and Biomaterials, University of Lille,
Inserm, Lille, France.; Controlled Drug Delivery Systems and Biomaterials,
University of Lille, Inserm, Lille, France.; Controlled Drug Delivery Systems and
Biomaterials, University of Lille, Inserm, Lille, France.; Controlled Drug Delivery
Systems and Biomaterials, University of Lille, Inserm, Lille, France.; LIRIC -
Lille Inflammation Research International Center, University of Lille, Inserm,
Lille, France.; Controlled Drug Delivery Systems and Biomaterials, University of
Lille, Inserm, Lille, France.; Controlled Drug Delivery Systems and Biomaterials,
University of Lille, Inserm, Lille, France, Kevimy.agossa@univ-lille.fr.
PY - 2020
SN - 0894-8275 (Print)
SP - 305-309
T2 - American journal of dentistry
VL - 33
Y2 - 12
ID - 14172
ER -
TY - JOUR
AB - PURPOSE: To evaluate an injectable gel, recently proposed for the controlled
antiseptic gel, respectively. METHODS: The antimicrobial activity, injectability,
texture properties, swelling and water uptake of the gels were studied. RESULTS:
analysis revealed potential gel fragility. CLINICAL SIGNIFICANCE: The investigated
gel for local delivery of oxygen can help to selectively eradicate anaerobic
bacteria associated with periodontitis and promote the recovery of a healthy-
compatible oral flora.
AN - rayyan-563560074
AU - Sy, K.
AU - Flamme, J.
AU - Maquet, H.
AU - Chai, F.
AU - Nuet, C.
AU - Siepmann, F.
AU - Agossa, K.
IS - 6
KW - chlorhexidine
gel
human
periodontitis
LA - English
PY - 2020
SN - 0894-8275
SP - 305-309
T2 - Am J Dent
VL - 33
ID - 13448
ER -
TY - JOUR
AB - Smoking is notably one of the most serious factors causing various
periodontal problems, including bacteria in plaque build up and yellow teeth. Based
on our study revealed that an activated charcoal from palm shells has been proven
as a teeth whitening with an absorption ability of two times higher than other
commercially active charcoals. This study aims to determine four formulas of
toothpaste which are useful as teeth whitening. The results showed that all of the
four formulas were proven effective as teeth whitening with the VITAPAN level of C1
(greyish shades) - all of which are similar to the positive control. The second
formula was verified as the best physical property compared with the other
formulas, with the quality standard at the concentration of carbomer 940 of 1% and
tween 80 of 1.5%.
AN - rayyan-563560176
AU - Syamsurizal
AU - Lestari, U.
AU - Nurhasanah
IS - 1
KW - activated carbon
benzoic acid
carbomer
glycerol
nicotine
polysorbate 80
toothpaste
triethanolamine
article
Elaeis guineensis
foam
gel
nonhuman
pH
tobacco dependence
viscosity
LA - English
PY - 2019
SN - 0976-044X
SP - 9-12
ST - Formulation of toothpaste activated charcoal from palm shell (elaeis
guineensis JACG) as teeth whitening for nicotine addicts
T2 - Int. J. Pharm. Sci. Rev. Res.
TI - Formulation of toothpaste activated charcoal from palm shell (elaeis
guineensis JACG) as teeth whitening for nicotine addicts
VL - 58
ID - 13550
ER -
TY - JOUR
AB - Traditional methods of non-surgical treatment of periodontitis, including
mechanical scaling/root planing (SRP), do not guarantee remission of the disease.
Local delivery of antimicrobial agents in periodontitis entails antimicrobial
therapy placed directly in periodontal pockets. The advantage of this form of
treatment is that the concentration of the drug after application significantly
exceeds the minimum inhibitory concentration (MIC) and persists for up to several
weeks. Therefore, many systems of locally applied devices, using a variety of
antibiotics or antiseptics have been developed. There is continuous research aimed
at introducing new forms of locally administered drugs, some of which have not
proved to be effective, while others are promising. For almost 30 years such
systems have been used for treatment as an adjuvant to SRP, and their efficacy has
been evaluated. The aim of this article is to systematically review the
contemporary literature regarding the currently available chemotherapeutics locally
administered in the treatment of periodontitis.
AN - rayyan-563562284
AU - Szulc, M.
AU - Zakrzewska, A.
AU - Zborowski, J.
DO - 10.17219/dmp/94890
IS - 3
PY - 2018
SN - ["1644-387X", "2300-9020"]
SP - 333-342
ST - Local drug delivery in periodontitis treatment: A review of contemporary
literature
T2 - DENTAL AND MEDICAL PROBLEMS
TI - Local drug delivery in periodontitis treatment: A review of contemporary
literature
VL - 55
Y2 - 7
ID - 15658
ER -
TY - JOUR
AB - Chitosan - one of the natural multifunctional polymers - due to its unique
and versatile biological properties is regarded as a useful compound in medical and
pharmaceutical technology. Recently, considerable research effort has been made in
order to develop safe and efficient chitosan products. However, the problem of poor
stability of chitosan-based systems restricts its practical applicability; thus, it
has become a great challenge to establish sufficient shelf-life for chitosan
formulations. Improved stability can be assessed by controlling the environmental
factors, manipulating processing conditions (e.g., temperature), introducing a
proper stabilizing compound, developing chitosan blends with another polymer, or
modifying the chitosan structure using chemical or ionic agents. This review covers
the influence of internal, environmental, and processing factors on the long-term
stability of chitosan products. The aim of this paper is also to highlight the
latest developments which enable the physicochemical properties of chitosan-based
applications to be preserved upon storage.
AN - rayyan-563560386
AU - Szymańska, E.
AU - Winnicka, K.
DO - 10.3390/md13041819
IS - 4
KW - bimatoprost
buspirone
chitosan
chloramphenicol
cisplatin
citric acid
clotrimazole
dextran sulfate
fucoidin
insulin
metronidazole
microsphere
nanoconjugate
nanoparticle
ovalbumin
polymer
promethazine
xanthan
anxiety disorder
biodegradability
bone tissue
candidiasis
chondrocyte
chemical structure
complex formation
cross linking
deacetylation
diabetes mellitus
dispersion
dissolution
drug dosage form
drug formulation
dry powder inhaler
freeze drying
gamma irradiation
gel
glaucoma
heating
humidity
hydrogel
hydrolysis
lung cancer
migraine
moisture
molecular weight
mucoadhesion
periodontal disease
pharmaceutical engineering
pharmaceutics
physical chemistry
review
shelf life
spray drying
tissue engineering
viscosity
wound
Celox
Chitodine
ChitoFlex
ChitoPack C
ChitoSeal
Clo-Sur
HemCon
KiOcardio
LipoSan Ultra
Liposorb
PosiSep
Slim Med
Syvek Excel
Tegasorb
TraumaStat
Vulnosorb
LA - English
PY - 2015
SN - 1660-3397
SP - 1819-1846
ST - Stability of chitosan - A challenge for pharmaceutical and biomedical
applications
T2 - Mar. Drugs
TI - Stability of chitosan - A challenge for pharmaceutical and biomedical
applications
VL - 13
ID - 13760
ER -
TY - JOUR
AB - Aloe vera has antimicrobial activity and enhances the osseointegration
process, thus it may have the potential in treating periodontal defects. This study
aimed to evaluate the effect of Aloe vera as an adjunction to Beta-tricalcium
phosphate (beta-TCP) bone graft in Grade II furcation defects. A randomized study
was conducted on six healthy mongrel dogs' premolars. A total of twenty-four Grade
II furcation critical-sized defects were surgically created after reflecting a
full-thickness flap, twelve defects were filled with beta-TCP while the other
twelve defects were filled with Aloe vera mixed with beta-TCP and both covered by
collagen membrane. Animals were euthanized at the end of the fourth and eighth week
and defects were analyzed histologically and histomorphometrically. Histologically,
Aloe vera mixed with beta-TCP resulted in more bone formation and new PDL fibers
compared to beta-TCP alone. After 2 and 4 weeks, the experimental group had
significantly higher newly formed interradicular bone height (p < 0.0001, and p <
0.0001, respectively), bone thickness (p < 0.0001, and p < 0.0001, respectively),
and percentage of the surface area (p = 0.009, and p = 0.023, respectively). Aloe
vera gel adjunctive to beta-TCP is an effective bioactive agent that enhances
periodontal tissue regeneration and bone formation in critically sized defects.
AN - rayyan-563562568
AU - Taalab, M. R.
AU - Abd El Rehim, S. S.
AU - Eldeeb, D. W.
AU - El-Moslemany, R. M.
AU - Abdelrahman, H.
DO - 10.1038/s41598-023-31282-8
IS - 1
PY - 2023
SN - 2045-2322
ST - Histologic and histomorphometric evaluation of Aloe vera adjunctive to beta-
tricalcium phosphate in class II furcation defects in dogs
TI - Histologic and histomorphometric evaluation of Aloe vera adjunctive to beta-
VL - 13
Y2 - 3 y3 - 14
ID - 15942
ER -
TY - JOUR
AB - Background The gold standard in treatment of periodontitis is mechanical
removing of dental biofilm but using local delivery drugs as adjunctive to SRP is
widely used to modulate inflammatory host and eradicate microbes. Tea tree oil
(TTO) has a broad-spectrum antimicrobial, anti-inflammatory, antifungal, antiviral,
antioxidant effect. This study aimed to assess clinically and biochemically the
effect of intrapocket application of TTO (Melaleuca alternifolia) gel adjunctive to
scaling and root planing (SRP) in the treatment of stage 2 (moderate) periodontitis
and to correlate the biochemical levels with clinical response. Methods A
randomized, controlled clinical trial was conducted on thirty patients with stage 2
periodontitis. Patients were equally divided into two groups: Control Group treated
with (SRP) alone and Test Group treated with SRP and locally delivered 5% TTO gel.
Clinical assessment included pocket probing depth (PPD), clinical attachment loss
(CAL), gingival index (GI) and bleeding on probing (BOP) measured at baseline and
after 3 and 6 months. The level of matrix metalloproteinase-8 (MMP-8), in the
gingival crevicular fluid (GCF) was also assessed at baseline and after1, 3 and 6
months by Enzyme-linked immunosorbent assay (ELISA) kit. Chi-square, Student t-
tests, Mann-Whitney U test and Spearman correlation were the statistical tests used
in the study. Results An improvement of all clinical and biochemical parameters was
observed (at p < 0.001) in both groups. A significant difference between the two
groups was found in both clinical and biochemical parameters. Conclusion The local
delivery of TTO gel adjunctive to SRP proved to be effective in the treatment of
stage II periodontitis. Trial registration The study was retrospectively registered
at clinicaltrials.gov NCT04769271, on 24/2/2021.
AN - rayyan-563562181
AU - Taalab, M. R.
AU - Mahmoud, S. A.
AU - El Moslemany, R. M.
AU - Abdelaziz, D. M.
DO - 10.1186/s12903-021-01588-y
IS - 1
PY - 2021
SN - 1472-6831
ST - Intrapocket application of tea tree oil gel in the treatment of stage 2
periodontitis
TI - Intrapocket application of tea tree oil gel in the treatment of stage 2
periodontitis
VL - 21
Y2 - 5 y3 - 5
ID - 15555
ER -
TY - JOUR
AB - BACKGROUND: The gold standard in treatment of periodontitis is mechanical
removing of dental biofilm but using local delivery drugs as adjunctive to SRP is
widely used to modulate inflammatory host and eradicate microbes. Tea tree oil
(TTO) has a broad-spectrum antimicrobial, anti-inflammatory, antifungal, antiviral,
antioxidant effect. This study aimed to assess clinically and biochemically the
effect of intrapocket application of TTO (Melaleuca alternifolia) gel adjunctive to
scaling and root planing (SRP) in the treatment of stage 2 (moderate) periodontitis
and to correlate the biochemical levels with clinical response. METHODS: A
randomized, controlled clinical trial was conducted on thirty patients with stage 2
periodontitis. Patients were equally divided into two groups: Control Group treated
with (SRP) alone and Test Group treated with SRP and locally delivered 5% TTO gel.
Clinical assessment included pocket probing depth (PPD), clinical attachment loss
(CAL), gingival index (GI) and bleeding on probing (BOP) measured at baseline and
after 3 and 6 months. The level of matrix metalloproteinase-8 (MMP-8), in the
gingival crevicular fluid (GCF) was also assessed at baseline and after1, 3 and 6
months by Enzyme-linked immunosorbent assay (ELISA) kit. Chi-square, Student t-
tests, Mann-Whitney U test and Spearman correlation were the statistical tests used
in the study. RESULTS: An improvement of all clinical and biochemical parameters
was observed (at p < 0.001) in both groups. A significant difference between the
two groups was found in both clinical and biochemical parameters. CONCLUSION: The
local delivery of TTO gel adjunctive to SRP proved to be effective in the treatment
of stage II periodontitis. Trial registration The study was retrospectively
registered at clinicaltrials.gov NCT04769271, on 24/2/2021.
AN - rayyan-563559994
AU - Taalab, M. R.
AU - Mahmoud, S. A.
AU - Moslemany, R. M. E.
AU - Abdelaziz, D. M.
DO - 10.1186/s12903-021-01588-y
IS - 1
KW - NCT04769271
tea tree oil
controlled study
dental scaling
gingivitis
human
periodontitis
root planing
LA - English
PY - 2021
SN - 1472-6831
SP - 239
ST - Intrapocket application of tea tree oil gel in the treatment of stage 2
periodontitis
TI - Intrapocket application of tea tree oil gel in the treatment of stage 2
periodontitis
VL - 21
ID - 13368
ER -
TY - JOUR
AB - Aloe vera has antimicrobial activity and enhances the osseointegration
process, thus it may have the potential in treating periodontal defects. This study
aimed to evaluate the effect of Aloe vera as an adjunction to Beta-tricalcium
phosphate (β-TCP) bone graft in Grade II furcation defects. A randomized study was
conducted on six healthy mongrel dogs' premolars. A total of twenty-four Grade II
furcation critical-sized defects were surgically created after reflecting a full-
thickness flap, twelve defects were filled with β-TCP while the other twelve
defects were filled with Aloe vera mixed with β-TCP and both covered by collagen
membrane. Animals were euthanized at the end of the fourth and eighth week and
defects were analyzed histologically and histomorphometrically. Histologically,
Aloe vera mixed with β-TCP resulted in more bone formation and new PDL fibers
compared to β-TCP alone. After 2 and 4 weeks, the experimental group had
significantly higher newly formed interradicular bone height (p < 0.0001, and p <
0.0001, respectively), bone thickness (p < 0.0001, and p < 0.0001, respectively),
and percentage of the surface area (p = 0.009, and p = 0.023, respectively). Aloe
vera gel adjunctive to β-TCP is an effective bioactive agent that enhances
periodontal tissue regeneration and bone formation in critically sized defects.
AN - rayyan-563559739
AU - Taalab, M. R.
AU - Rehim, S. S. A. E.
AU - Eldeeb, D. W.
AU - El-Moslemany, R. M.
AU - Abdelrahman, H.
DO - 10.1038/s41598-023-31282-8
IS - 1
Aloe
animal
bone regeneration
dog
periodontal disease
LA - English
PY - 2023
SN - 2045-2322
SP - 4198
ST - Histologic and histomorphometric evaluation of Aloe vera adjunctive to β-
T2 - Sci Rep
TI - Histologic and histomorphometric evaluation of Aloe vera adjunctive to β-
VL - 13
ID - 13113
ER -
TY - JOUR
AB - Aims of the study:To evaluate the clinical efficacy of PRF with 1%alendronate
gel combination in mandibular degree II furcation defect treatment in comparison
with 1%ALN and access therapy alone. Materials and Methods: Twenty-four mandibular
molar furcation defects were treated with either access therapy alone (group 1),
access therapy with1% ALN gel (group 2), or access therapy with PRF and 1% ALN
(group 3). Plaque index, modified sulcus bleeding index, probing pocket depth
(PPD), relative vertical attachment level (RVAL) and relative horizontal attachment
level (RHAL), and intrabony defect depth were recorded at baseline and 6 months
postoperatively. Radiographically, defect fill, was evaluated at baseline before
surgery, and 6months post-therapy. Results:: Group3 demonstrated significant
reduction in PPD, RVAL and RHAL gain in compare to ALN and control groups
postopratively.Furthermore, group3 showed greater significant reduction in
intrabony defect(1.25±0.49) when compared to group2(0.45±0.17) and group 1(0.16
±0.5). Conclusions:The local delivery of 1% ALN gel combined with autologous PRF in
Furcation defect treatment showed better clinical parameters outcomes with greater
bone defect depth reduction in comparison to 1%ALN and access therapy alone.
AN - rayyan-563560190
AU - Tahir Al-Khaiyat, M. A.
AU - Saliem, S. S.
AU - Abdulbaqi, H. R.
AU - Thumad, M. M.
IS - 5
KW - cannula
scalpel
alendronic acid
amoxicillin
chlorhexidine
gelling agent
ibuprofen
metronidazole
adult
article
comparative study
controlled study
dental debridement
dental scaling
dental surgery
female
human
jaw disease
male
mouth hygiene
periodontal disease
plaque index
relative horizontal attachment level
relative vertical attachment level
root planing
vein puncture
LA - English
PY - 2019
SN - 0975-1459
SP - 1856-1860
ST - Mandibular degree ii furcation defect treatment with 1%alendronate gel alone
or in combination with platelet- Rich fibrin
T2 - J. Pharm. Sci. Res.
TI - Mandibular degree ii furcation defect treatment with 1%alendronate gel alone
or in combination with platelet- Rich fibrin
VL - 11
ID - 13564
ER -
TY - JOUR
AB - A mouth infection can also affect the teeth, the mouth tissues, and any other
areas involved in the mouth. Biofilms formed by bacteria are the primary cause of
mouth infections and other infectious diseases caused by bacteria. The most common
dental problem is an infection or disease within the mouth. The term chronic
infection is sometimes used to describe this type of problem. There is also the
possibility that these discomforts may occur due to the presence of bacteria in
plaque, which is responsible for causing inflammation throughout the body as a
result of bacterial infection in the mouth. In many cases, antibiotics serve as a
first-line treatment for mouth infections, especially those caused by bacteria,
most commonly treated by antibiotics. It is common for antibiotics to be used
orally, and they are absorbed into the body through their metabolism in the liver
and kidneys. Antibiotic resistance, which is primarily caused by misuse and overuse
of antibiotics, is also one of the most significant public health crises of the
21st century. With the help of new drug delivery systems, antibacterial resistance
can be decreased in humans to maintain the effectiveness of antibiotics when they
are used more frequently. By directly delivering antibiotics to damaged tissues and
reducing undesirable side effects when administered systemically, antibiotic
delivery systems enhance the efficiency of antibiotics in specific zones.
Furthermore, several new delivery systems are being explored in an attempt to
improve pharmacokinetics and pharmacodynamics, reduce bacterial resistance, and
decrease dose times. As a result, antibiotics were delivered to tissues and
biological fluids using an innovative delivery system. Research on some of the most
prevalent dental diseases provides updates on antibiotic delivery systems that
reduce antibiotic resistance. This review overviews oral infectious diseases,
antibiotics effects, and the different delivery systems of these therapeutic
approaches.
AN - rayyan-563559927
AU - Tahmasebi, E.
AU - Ardestani, A. K.
AU - Hassani, Z.
AU - Alam, M.
AU - Abbasi, K.
AU - Kahrizi, S.
AU - Madihi, N.
AU - Abbasiparashkouh, Z.
AU - Mohammadi, A.
AU - Shahab, P.
AU - Khayatan, D.
AU - Yazdanian, M.
DO - 10.14715/CMB/2022.68.10.23
IS - 10
KW - tooth implant
antibiotic agent
clindamycin
hydrogel
metronidazole
nanoparticle
pectin
body fluid
dental restoration
gingivitis
human
lung disease
Medline
osteomyelitis
periimplantitis
periodontitis
pharmacodynamic parameters
review
ScienceDirect
search engine
social change
tooth infection
LA - English
PY - 2022
SN - ["1165-158X", "0145-5680"]
SP - 141-160
ST - The current novel drug delivery system (natural and chemical composites) in
dental infections for antibiotics resistance: a narrative review
T2 - Cell. Mol. Biol.
TI - The current novel drug delivery system (natural and chemical composites) in
dental infections for antibiotics resistance: a narrative review
VL - 68
ID - 13301
ER -
TY - JOUR
AB - The purpose of this investigation was to examine by reverse-transcriptase
polymerase chain reaction analysis the osteogenic differentiation of twice-passaged
Sprague-Dawley rat bone marrow stromal cells in type I collagen gel cultured for 3
weeks. Two culture media were used here, namely Dulbecco's modified Eagle (DME)
medium supplemented with vitamin C [Dex (-)] and those with vitamin C,
dexamethasone and β-glycerophosphate [Dex (+)]. Culture with Dex (-) medium in
collagen gel for 3 weeks brought about the well-developed cell network and middle-
stage osteogenic phenotype expression characterized by mRNA for alkaline
phosphatase, osteonectin and osteopontin while those for bone sialo protein and
osteocalcin were not detected. On the contrary, culture with Dex (+) medium in
collagen gel for 3 weeks lead to necrosis of the cells. These results indicate that
culture in collagen gel with Dex (-) DME medium containing vitamin C was useful for
three-dimensional culture and middle-stage osteogenic differentiation of twice-
passaged bone marrow stromal cells. This study might contribute to tissue
engineering therapy to fix bone and periodontal defects in the future.
AN - rayyan-563560880
AU - Taira, M.
AU - Toyosawa, S.
AU - Ijyuin, N.
AU - Takahashi, J.
AU - Araki, Y.
DO - 10.1046/j.1365-2842.2003.01170.x
IS - 8
ascorbic acid
collagen gel
collagen type 1
dexamethasone
messenger RNA
osteocalcin
osteonectin
osteopontin
sialoprotein
animal cell
article
bone development
bone marrow cell
cell culture
cell death
controlled study
culture medium
gene expression
male
nonhuman
phenotype
rat
stroma cell
tissue engineering
LA - English
PY - 2003
SN - 0305-182X
SP - 802-807
ST - Studies on osteogenic differentiation of rat bone marrow stromal cells
cultured in type I collagen gel by RT-PCR analysis
T2 - J. Oral Rehabil.
TI - Studies on osteogenic differentiation of rat bone marrow stromal cells
cultured in type I collagen gel by RT-PCR analysis
VL - 30
ID - 14254
ER -
TY - JOUR
AN - rayyan-563562132
AU - Taiwo, O.
AU - Xu, H. X.
AU - Lee, S. F.
DO - 10.1002/(SICI)1099-1573(199912)13:8<675::AID-PTR513>3.0.CO;2-X
IS - 8
PY - 1999
SP - 675-679
ST - Antibacterial activities of extracts from Nigerian chewing sticks
T2 - Phytotherapy Research
TI - Antibacterial activities of extracts from Nigerian chewing sticks
UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032806310&doi=10.1002%2f
%28SICI%291099-1573%28199912%2913%3a8%3c675%3a%3aAID-PTR513%3e3.0.CO%3b2-
X&partnerID=40&md5=eaf4b1bf418de27a0c3db093b229b12f
VL - 13
ID - 15506
ER -
TY - JOUR
AB - Background: Auto-brewery syndrome (ABS) is often caused by fungi in the
intestinal tract. We describe a rare case of alcohol production by Candida albicans
and periodontal disease bacteria in the oral cavity. Case Presentation: A man aged
in his 60s had a car accident, and alcohol was detected on his breath. At the time,
he exhibited alcohol overdose seizures with no alcohol consumption. We carried out
a gastrointestinal endoscopy, detected esophageal candidiasis, and diagnosed ABS.
His seizures continued despite using miconazole oral gel. Significant tooth decay,
periodontal disease, and high C. albicans levels were observed in his oral cavity.
Alcohol production was confirmed from periodontal bacteria and C. albicans cultures
and alcohol-degrading enzyme functions were poor. Dental treatment and antifungal
drugs reduced seizures, and improved his fatty liver. Conclusion: Alcohol can be
produced by microorganisms in healthy individuals. Therefore, blood alcohol levels
and alcohol-degrading enzyme functions should be examined in patients with
unexplained liver dysfunction.
AN - rayyan-563560052
AU - Takahashi, G.
AU - Hoshikawa, K.
AU - Kan, S.
AU - Akimaru, R.
AU - Kodama, Y.
AU - Sato, T.
AU - Kakisaka, K.
AU - Yamada, Y.
DO - 10.1002/ams2.652
IS - 1
KW - amphotericin B
micafungin
miconazole
povidone iodine
adult
article
auto brewery syndrome
bacterial count
bacterial infection
Candida albicans
case report
clinical article
Corynebacterium
dental procedure
Enterobacter cloacae
esophagus candidiasis
gastrointestinal endoscopy
human
Leuconostoc lactis
male
mycosis
neuropathy
periodontal disease
seizure
Streptococcus mitis
LA - English
PY - 2021
SN - 2052-8817
ST - Auto-brewery syndrome caused by oral fungi and periodontal disease bacteria
T2 - Acute Med. Surg.
TI - Auto-brewery syndrome caused by oral fungi and periodontal disease bacteria
VL - 8
ID - 13426
ER -
TY - JOUR
AB - Fifteen Bacteroides forsythus strains freshly isolated from patients with
periodontitis were used together with three collection strains and one type strain
for characterization of growth on various media; determination of enzymatic
profiles, antibiotic susceptibility profiles, 16S rRNA ribotypes, sodium dodecyl
sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) outer membrane protein
profiles, and pathogenicity; and gas chromatography analysis by using a wound
chamber model in rabbits, All strains were stimulated by N-acetylmuramic acid,
while one strain needed a further supplement such as yeast extract for optimal
growth, All strains showed trypsin-like activity, While 10 different ribotypes were
found, the SDS-PAGE profiles revealed similar patterns for all strains, All strains
were sensitive to penicillin G (MICs, <0.5 mu g/ml), ampicillin (MICs, <1.0 mu
g/ml), amoxicillin (MICs, <0.38 mu g/ml), metronidazole (MICs, <0.005 mu g/ml),
tetracycline (MICs, <0.19 mu g/ml), doxycycline (MICs, 0.05 mu g/ml), erythromycin
(MICs, <0.4 mu g/ml), and clindamycin (MICs, <0.016 mu g/ml), while they were less
sensitive to ciprofloxacin (MICs, <4 mu g/ml). B. forsythus did not cause abscess
formation by monoinoculation. B. forsythus coinoculated with Fusobacterium
nucleatum ATCC 10953 caused abscess formation in 75% of rabbits, while it caused
abscess formation in 100% of rabbits when it was coinoculated with Porphyromonas
gingivalis FDC 381. In the case of the latter combination, four of six rabbits died
of sepsis after 6 to 7 days, and P. gingivalis and B. forsythus were recovered from
the heart blood at a proportion of 10:1, B. forsythus strains were highly virulent
and invasive in combination with P. gingivalis.
AN - rayyan-563562615
AU - Takemoto, T.
AU - Kurihara, H.
AU - Dahlen, G.
DO - 10.1128/JCM.35.6.1378-1381.1997
IS - 6
PY - 1997
SN - 0095-1137
SP - 1378-1381
ST - Characterization of Bacteroides forsythus isolates
T2 - JOURNAL OF CLINICAL MICROBIOLOGY
TI - Characterization of Bacteroides forsythus isolates
VL - 35
Y2 - 6
ID - 15989
ER -
TY - JOUR
AB - We suggest here that Porphyromonas gingivalis DNA may function as a virulence
factor in periodontal disease through expression of inflammatory cytokine. The
bacterial DNA markedly stimulated in a dose-dependent manner interleukin-6 (IL-6)
production by human gingival fibroblasts. The stimulatory action was eliminated by
treatment with DNase but not RNase. The stimulatory effect was not observed in the
fibroblasts treated with eucaryotic DNAs. The bacterial DNA also stimulated in
dose- and treatment time-dependent manners the expression of the IL-6 gene in the
cells. In addition, the stimulatory effect was eliminated when the DNA was
methylated with CpG motif methylase. Interestingly, a 30-base synthetic
oligonucleotide containing the palindromic motif GACGTC could stimulate expression
of the IL- 6 gene and production of its protein in the cells. Furthermore, the
synthetic oligonucleotide-induced expression of this cytokine gene was blocked by
pyrrolidine dithiocarbamate and N-acetyl-L-cystine, potent inhibitors of
transcriptional factor NF-κB. Gel mobility shift assay showed increased binding of
NF-κB to its consensus sequence in the synthetic oligonucleotide- treated cells.
Also, using specific antibody against p50 and p65, which compose NF-κB, we showed
the consensus sequence-binding proteins to be NF- κB. These results are the first
to demonstrate that the internal CpG motifs in P. gingivalis DNA stimulate IL-6
expression in human gingival fibroblasts via stimulation of NF-κB.
AN - rayyan-563561017
AU - Takeshita, A.
AU - Imai, K.
AU - Hanazawa, S.
DO - 10.1128/iai.67.9.4340-4345.1999
IS - 9
KW - bacterial DNA
cytokine
interleukin 6
article
bacterial infection
bacterial virulence
controlled study
fibroblast
gingiva disease
human
human cell
inflammation
nonhuman
pathogenesis
periodontal disease
priority journal
LA - English
PY - 1999
SN - 0019-9567
SP - 4340-4345
ST - CpG motifs in Porphyromonas gingivalis DNA stimulate interleukin-6 expression
in human gingival fibroblasts
T2 - Infect. Immun.
TI - CpG motifs in Porphyromonas gingivalis DNA stimulate interleukin-6 expression
in human gingival fibroblasts
VL - 67
ID - 14391
ER -
TY - JOUR
AB - Arg-gingipain (Rgp) and Lys-gingipain (Kgp) are Porphyromonas gingivalis
cysteine proteinases implicated as major virulence factors in pathologies of
periodontitis. We purified a 660-kDa cell-associated gingipain complex existing as
a homodimer of two catalytically active monomers which comprises their catalytic
and adhesin domains. Electron microscopy revealed that the complex was composed of
a globular particle with a 10-nm external diameter possessing one or two electron-
dense hole-like structures. Two-dimensional gel electrophoresis and immunoblot
analyses revealed the association of lipopolysaccharide (LPS) with the catalytic
domains and a hemagglutinin domain, Hgp44, of Rgp and Kgp in the complex. The
complex significantly degraded human type I collagen and elastin and strongly
disrupted viability of human gingival flbroblasts and umbilical vein endotherial
cells with an efficiency which was higher than that of the monomeric gingipains.
The native complex produced only a small amount of nitrogen dioxide, tumor necrosis
factor alpha, and interleukin-6 by macrophages, whereas the heat-denatured complex
resulted in increased production. Inhibition of the proteolytic activities of the
gingipain complex did not up-regulate the cytokine production, indicating that the
functional domains in LPS are structurally masked by the complex proteins. These
results indicate the importance of the complex in evasion of host defense
mechanisms as well as in host tissue breakdown.
AN - rayyan-563560849
AU - Takii, R.
AU - Kadowaki, T.
AU - Baba, A.
AU - Tsukuba, T.
AU - Yamamoto, K.
DO - 10.1128/IAI.73.2.883-893.2005
IS - 2
KW - adhesin
collagen type 1
cysteine proteinase
dimer
elastin
gingipain R
hemagglutinin
interleukin 6
lipopolysaccharide
lysine gingipain
matrix protein
monomer
nitrogen dioxide
protein Hgp44
unclassified drug
virulence factor
antigen recognition
article
binding affinity
catalysis
complex formation
controlled study
cytokine production
denaturation
electron microscopy
host cell
host resistance
human
human cell
immune system
immunoblotting
macrophage
nonhuman
particle size
periodontitis
priority journal
protein degradation
protein domain
LA - English
PY - 2005
SN - 0019-9567
SP - 883-893
ST - A functional virulence complex composed of gingipains, adhesins, and
lipopolysaccharide shows high affinity to host cells and matrix proteins and
escapes recognition by host immune systems
T2 - Infect. Immun.
TI - A functional virulence complex composed of gingipains, adhesins, and
lipopolysaccharide shows high affinity to host cells and matrix proteins and
escapes recognition by host immune systems
VL - 73
ID - 14223
ER -
TY - JOUR
AB - Microbial biofilms are microcosm attaching irreversibly to abiotic or biotic
surfaces and they are promulgated as congregate of single or multiple populations.
The potential of lipid- and polymer-based drug delivery carriers for eradicating
biofilm consortia on device-related nosocomial infections is explored in this
review. Liposomes-loaded with antimicrobial agents could effectively be applied as
anti-biofilm coating to reduce microbial adhesion/colonisation onto medical devices
and as drug delivery carriers to biofilm interfaces and in intracellular infection.
Many polymer-based carrier systems have also been proposed, including those based
on biodegradable polymers such as poly(lactide co-glycolide) as well as fibrous
scaffolds and thermoreversible hydrogels and surface (properties) modified
polymeric catheter materials such as antimicrobial, antiseptic or metallic
substances-coated polymeric materials. Their contribution to the
prevention/resolution of infection is reviewed. © 2008 Elsevier B.V. All rights
reserved.
AN - rayyan-563560707
AU - Tamilvanan, S.
AU - Venkateshan, N.
AU - Ludwig, A.
DO - 10.1016/j.jconrel.2008.01.006
IS - 1
KW - amoxicillin
antibiotic agent
antiinfective agent
cephalosporin
chlorhexidine
ciprofloxacin
cotrimoxazole
dalfopristin plus quinupristin
ketoconazole
lipid
metronidazole
minocycline
polyglactin
polymer
rifampicin
sulfadiazine silver
tetracycline
vancomycin
biofilm
drug activity
hospital infection
hydrogel
in vitro study
nonhuman
periodontitis
priority journal
review
septicemia
LA - English
PY - 2008
SN - 0168-3659
SP - 2-22
ST - The potential of lipid- and polymer-based drug delivery carriers for
eradicating biofilm consortia on device-related nosocomial infections
TI - The potential of lipid- and polymer-based drug delivery carriers for
eradicating biofilm consortia on device-related nosocomial infections
VL - 128
ID - 14081
ER -
TY - JOUR
AN - rayyan-563561946
AU - Tamura, M.
AU - Ochiai, K.
DO - 10.1016/j.jdsr.2012.02.004
IS - 2
PY - 2012
SP - 126-134
ST - Exploring the possible applications of catechin (gel) for oral care of the
elderly and disabled individuals
T2 - Japanese Dental Science Review
TI - Exploring the possible applications of catechin (gel) for oral care of the
elderly and disabled individuals
84864312078&doi=10.1016%2fj.jdsr.2012.02.004&partnerID=40&md5=be29e0ec28efc27e5f847
986c7001f59
VL - 48
ID - 15320
ER -
TY - JOUR
AB - The oral cavity contains almost half of the commensal bacterial population
present in the human body. An increase in the number of these microorganisms may
result in systemic diseases such as infective endocarditis and aspiration pneumonia
as well as oral infections. It is essential to control the total numbers of these
microorganisms in order to suppress disease onset. Thus, we examined the
antimicrobial activity of a newly developed gel-entrapped catechin (GEC)
preparation against oral microorganisms. The minimum inhibitory concentration (MIC)
of GEC was determined based on the relationship between a modified agar diffusion
method and a broth microdilution method. GEC inhibited the growth of the
Actinomyces, periodontopathic bacteria and Candida strains tested, but did not
inhibit the growth of the oral streptococci that are important in the normal oral
flora. Commercially available moisture gels containing antimicrobial components
showed antimicrobial activity against all of the tested strains. After a series of
washes and after a 24-h incubation, GEC retained the antimicrobial activity of the
catechins. Catalase prevented GEC-induced growth inhibition of Actinomyces
naeslundii and Streptococcus mutans suggesting that hydrogen peroxide may be
involved in the antimicrobial activity of catechins. These results suggest that GEC
may be useful for controlling oral microorganism populations and reducing the
accumulation of dental plaque, thereby helping to prevent periodontal disease and
oral candidiasis. © 2011 Pharmaceutical Society of Japan.
AN - rayyan-563560596
AU - Tamura, M.
AU - Saito, H.
AU - Kikuchi, K.
AU - Ishigami, T.
AU - Toyama, Y.
AU - Takami, M.
AU - Ochiai, K.
DO - 10.1248/bpb.34.638
IS - 5
KW - catalase
catechin
chlorhexidine
epicatechin
epicatechin gallate
epigallocatechin
gallocatechin
hydrogen peroxide
Actinomyces
agar diffusion
article
bacterial growth
broth dilution
Candida
controlled study
drug effect
drug efficacy
drug synthesis
encapsulation
fungal strain
gel
growth inhibition
in vitro study
incubation time
mouth flora
nonhuman
LA - English
PY - 2011
SN - ["0918-6158", "1347-5215"]
SP - 638-643
ST - Antimicrobial activity of gel-entrapped catechins toward oral microorganisms
T2 - Biol. Pharm. Bull.
TI - Antimicrobial activity of gel-entrapped catechins toward oral microorganisms
VL - 34
ID - 13970
ER -
TY - JOUR
AB - Background and Aim: Nonsurgical periodontal treatment with subgingival
instrumentation alone may not be as effective in some clinical situations. Thus,
adjunctive therapy should be considered to enhance periodontal treatment outcomes.
This study aimed to evaluate the effect of a commercially available locally
delivered synthetic antimicrobial peptide (AMP) gel as an adjunct in nonsurgical
periodontal treatment. Methods: Four stage III periodontitis-affected subjects were
recruited in a split-mouth study of 12-week follow-up. After full mouth
professional mechanical plaque removal and subgingival instrumentation, all sites
with probing pocket depth 6-7 mm were randomly assigned to test (AMP) or control
(normal saline) group. Clinical examination and subgingival plaque sampling were
performed at baseline, 6 weeks, and 12 weeks. Clinical data was analysed with SPSS
software. Subgingival plaque samples were analysed by 16S rRNA-gene sequencing,
QIIME pipeline, and R software. Results: Clinical parameters were significantly
improved in both groups at 6 weeks, and 12 weeks follow-up (p < 0.05). There was no
significant difference in PPD between groups, although greater reduction was
observed in the test group. Adjunctive application of AMP demonstrated greater CAL
gain (p < 0.05) at 12 weeks as compared to the control group. Using Shannon index,
alpha diversity decreased after treatments and was significantly lower in the
control group at 6 weeks. Principle coordinate analysis demonstrated a clear
separation between pre-and post-treatment samples in the test group. At the genus
level, a decrease in diseased-associated bacteria and an increase in health-
associated bacteria were observed after both treatments. The genus Tannerellawas
significantly less abundant at 12 weeks compared to baseline in the test group.
Conclusions: Local application of AMP gel in conjunction with subgingival
instrumentation resulted in modest beneficial changes in clinical outcome and
subgingival bacterial composition, supporting its potential as an adjunct to
nonsurgical periodontal therapy.
AN - rayyan-563559837
AU - Tan, H. S.
AU - Hussin, M. Z.
AU - Safii, S. H.
AU - Amin Nordin, S.
DO - 10.1111/jcpe.13636
KW - endogenous compound
RNA 16S
sodium chloride
adult
case report
clinical article
clinical outcome
conference abstract
female
follow up
gene sequence
human
male
metagenomics
mouth
outcome assessment
periodontitis
periodontium
pilot study
pipeline
Shannon index
LA - English
PY - 2022
SN - 1600-051X
SP - 175
ST - Clinical and metagenomic investigation of locally delivered synthetic
antimicrobial peptide in non-surgical periodontal treatment: A pilot study
TI - Clinical and metagenomic investigation of locally delivered synthetic
antimicrobial peptide in non-surgical periodontal treatment: A pilot study
VL - 49
ID - 13211
ER -
TY - JOUR
AB - Natural polysaccharide-based hydrogels have drawn much concern in the
biomedical fields. Among them, alginate, a natural polyanionic polysaccharide, has
become one of the research hotspots, because of its abundant source,
biodegradability, biocompatibility, solubility, modification flexibility, and other
characteristics or physiological functions. Recently, through adopting various
physical or chemical crosslinking strategies, selecting suitable crosslinking or
modification reagents, precisely controlling the reaction conditions, or
introducing organic or inorganic functional materials, a variety of alginate-based
hydrogels with excellent performance have been continuously developed, considerably
expanding the breadth and depth of their applications. Here, various crosslinking
strategies in the preparation of alginate-based hydrogels are comprehensively
introduced. The representative application progress of alginate-based hydrogels in
drug carrier, wound dressing and tissue engineering is also summarized. Meanwhile,
the application prospects, challenges and development trends of alginate-based
hydrogels are discussed. It is expected to provide guidance and reference for the
further development of alginate-based hydrogels.
AN - rayyan-563559704
AU - Tan, J.
AU - Luo, Y.
AU - Guo, Y.
AU - Zhou, Y.
AU - Liao, X.
AU - Li, D.
AU - Lai, X.
AU - Liu, Y.
DO - 10.1016/j.ijbiomac.2023.124275
KW - alginic acid
ampicillin
biomaterial
curcumin
dexamethasone
diclofenac
furazolidone
graphene oxide
hydrogel
hydroxyapatite
iron oxide
microsphere
molybdenum
paclitaxel
polyphenol
polysaccharide
Schiff base
tramadol
angiogenesis
biocompatibility
biodegradability
biological activity
biomedicine
bone regeneration
bone tissue
bone tumor
breast cancer
cell proliferation
cell survival
cell viability
chondrocyte
chondrogenesis
cross linking
cytotoxicity
encapsulation
Escherichia coli
fungicidal activity
Helicobacter pylori
human
hydrogen bond
nerve regeneration
nonhuman
oxidative stress
polymerization
prostate cancer
review
tensile strength
tissue engineering
tissue regeneration
viscoelasticity
wound healing
wound infection
LA - English
PY - 2023
SN - ["1879-0003", "0141-8130"]
ST - Development of alginate-based hydrogels: Crosslinking strategies and
biomedical applications
TI - Development of alginate-based hydrogels: Crosslinking strategies and
biomedical applications
VL - 239
ID - 13078
ER -
TY - JOUR
AB - This review aimed to rank the clinical efficacy of commercially available
single-application local drug delivery and adjunctive agents (LDAs) compared with
subgingival mechanical debridement (SMD) in nonsurgical periodontal therapy (NSPT).
Randomized controlled clinical trials that compared LDAs against SMD alone or with
placebo in adults (aged at least 18 years) diagnosed with periodontitis with a
minimum of 6 months follow-up were included. A frequentist approach to random-
effects network meta-analysis was implemented. The efficacies of the LDAs measured
by probing pocket depth (PPD) reduction and clinical attachment level (CAL) gain
were reported as mean difference (MD) with 95% confidence intervals (CIs). The
treatments were ranked according to their P-score. Four network meta-analyses
suggested that sulfonic/sulfuric acid gel (PPD MD −1.13 mm, 95% CI −1.74 to −0.53,
P-score 0.91; CAL MD −1.09 mm, 95% CI −1.58 to −0.61, P-score 0.95) and doxycycline
hyclate gel (PPD MD −0.90 mm, 95% CI −1.50 to −0.30, P-score 0.93; CAL MD −0.84 mm,
95% CI −1.40 to −0.28, P-score 0.92) were the most effective in reducing PPD and
gaining CAL in split-mouth and parallel studies, respectively (moderate certainty
of evidence). LDAs have differing efficacies, but they present with possible
clinical significance over SMD alone in NSPT.
AN - rayyan-563560076
AU - Tan, O. L.
AU - Safii, S. H.
AU - Razali, M.
IS - 11
KW - chlorhexidine
doxycycline
gel
indocyanine green
methylene blue
metronidazole
minocycline
phenothiazine
povidone iodine
sulfonic acid derivative
sulfuric acid
tetracycline
tolonium chloride
xanthan
confidence interval
data analysis
data extraction
dental debridement
follow up
human
meta analysis
periodontal disease
review
statistical bias
subgingival mechanical debridement
systematic review
LA - English
PY - 2020
SN - 1999-4923
SP - 1-21
ST - Clinical efficacy of single application local drug delivery and adjunctive
agents in nonsurgical periodontal therapy: A systematic review and network meta-
analysis
T2 - Pharmaceutics
TI - Clinical efficacy of single application local drug delivery and adjunctive
agents in nonsurgical periodontal therapy: A systematic review and network meta-
analysis
VL - 12
ID - 13450
ER -
TY - JOUR
AB - The aim of this systematic review is to compare the clinical efficacy of
repeated applications of local drug delivery and adjunctive agents (LDAs) in
nonsurgical periodontal therapy (NSPT) compared to subgingival mechanical
debridement (SMD) alone. The Cochrane Central Register of Controlled Trials,
MEDLINE, PubMed, EMBASE, Web of Science, hand-searched literature and grey
literature databases were searched for randomized controlled clinical trials (RCTs)
with a minimum of 6-month follow-up. The outcomes of interest were changes in
probing pocket depth and clinical attachment level as well as patient-centred
outcomes. Of 1094 studies identified, 16 RCTs were included in the qualitative
analysis. Across 11 different adjuncts analysed, only two studies utilizing
minocycline gel/ointment and antimicrobial photodynamic therapy (aPDT) with
indocyanine green photosensitizer had statistically significant differences in
primary outcomes when compared to their control groups. Only one study on aPDT
methylene blue 0.005% had compared single versus multiple applications against its
control group. A mean range of 0.27–3.82 mm PD reduction and −0.09–2.82 mm CAL gain
were observed with repeated LDA application. Considerable clinical heterogeneity
and methodological flaws in the included studies preclude any definitive
conclusions regarding the clinical efficacy of repeated LDA applications. Future
RCTs with a direct comparison between single and repeated applications should be
conducted to confirm or refute the clinical advantages of repeated LDA application
in the nonsurgical management of periodontitis.
AN - rayyan-563559954
AU - Tan, O. L.
AU - Safii, S. H.
AU - Razali, M.
IS - 10
KW - tooth implant
chlorhexidine
doxycycline
microsphere
minocycline
phenothiazine
povidone iodine
bleeding
clinical outcome
dental debridement
dentistry
disease severity
drug efficacy
human
interrater reliability
meta analysis
outcome assessment
periodontitis
periodontium
plaque index
review
root planing
systematic review
LA - English
PY - 2021
SN - 2079-6382
ST - Clinical efficacy of repeated applications of local drug delivery and
adjunctive agents in nonsurgical periodontal therapy: A systematic review
T2 - Antibiotics
TI - Clinical efficacy of repeated applications of local drug delivery and
adjunctive agents in nonsurgical periodontal therapy: A systematic review
VL - 10
ID - 13328
ER -
TY - JOUR
AB - Aim: The aim of this study was to investigate the presence of antigens with
immunological cross-reactivity in periodontopathogenic bacteria and Helicobacter
pylori, the pathogen associated with gastritis and peptic ulcers in human.
Materials and methods/Results: Among the putative periodontopathogens tested
(Actinobacillus actinomycetemcomitans, Campylobacter rectus, Fusobacterium
nucleatum, Porphyromonas gingivalis, Prevotella intermedia and Treponema
denticola), cross-reactive bands were only detected in C. rectus by
SDS-PAGE/Western immunoblotting analysis using a polyclonal antibody directed to H.
pylori cells. One of these cross-reactive antigens, a 64-kDa band antigen, also
reacted with a monoclonal antibody directed to the human heat shock protein (HSP)
60. The N-terminal amino acid sequence of this C. rectus protein revealed a high
degree of homology with corresponding regions of other HSPs belonging to the HSP60
family, indicating that the 64-kDa antigen was a GroEL protein. The nucleotide
sequence of the C. rectus GroEL protein coded for a 547 amino acid protein with a
predicted size of 57.8 kDa. Comparison of the alignment of the deduced amino acid
sequence of the GroEL protein of C. rectus with that of H. pylori showed a high
degree of similarity throughout its length (76.8%). GroEL protein from C. rectus
possessed the ability to stimulate production of IL-6 by a confluent monolayer of
human gingival epithelial cells and was cytotoxic when used at a high
concentration. Conclusions: This study reveals an immunological relationship
between H. pylori and C. rectus, and clearly indicates that one of the shared
antigens is a GroEL protein possessing a biological activity that might play a role
in the initiation and progression of periodontal disease.
AN - rayyan-563560886
AU - Tanabe, S.
AU - Hinode, D.
AU - Yokoyama, M.
AU - Fukui, M.
AU - Nakamura, R.
AU - Yoshioka, M.
AU - Grenier, D.
AU - Mayrand, D.
DO - 10.1034/j.1399-302X.2003.00049.x
IS - 2
KW - bacterial antigen
chaperonin
chaperonin 60
interleukin 6
polyclonal antibody
amino acid sequence
antigen antibody complex
antigenicity
article
bacterial cell
Campylobacter
controlled study
cross reaction
cytokine production
cytotoxicity
epithelium cell
genetic code
gingiva
Helicobacter pylori
nonhuman
nucleotide sequence
periodontitis
sequence analysis
Treponema denticola
Western blotting
LA - English
PY - 2003
SN - 0902-0055
SP - 79-87
ST - Helicobacter pylori and Campylobacter rectus share a common antigen
TI - Helicobacter pylori and Campylobacter rectus share a common antigen
VL - 18
ID - 14260
ER -
TY - JOUR
AB - Background. One of the most important measures to be undertaken in order to
fight gingivitis and periodontitis is maintenance of proper hygiene of the oral
cavity. The research to improve the content of toothpaste has continued for many
years so that they should become better in terms of therapeutic abilities.
Objectives. The aim of this work was to determine and investigate the influence of
the application of toothpaste and gel with 3% ethanol propolis extract on the state
of the oral cavity. Material and Methods. The research group comprised 80 adult
patients divided into two subgroups: Group I, which comprised 40 patients without
pathological changes within the boundaries of the periodontium, and Group II, also
40 patients endangered with the occurrence of periodontitis caused by dental plaque
and lack of proper hygiene of the oral cavity. Qualification for both groups was
based on an interview and analysis of clinical documentation and assessment of
adequate indices such as API, OHI and SBI. The patients underwent three
examinations: initial, follow-up after 7 days and after 8 weeks since the beginning
of the program. Moreover, the patients were instructed about hygienic procedures of
the oral cavity. Four groups (T, G, CT, CG), 20 patients each, were created from
research groups I and II. They used the following preparations: T - Dental Polis DX
toothpaste with propolis content, G - Dental Polis DX toothpaste without propolis
content, CT - Carepolis gel with propolis content, CG - Carepolis gel without
propolis content. The patients were informed about the type of hygienic preparation
they were given to use (whether it contained propolis or not). Moreover, they were
interviewed for their subjective evaluation of the product received. Results and
Conclusion. Results of the research show the effectiveness of hygienic preparations
with 3% content of ethanol propolis extract in both groups of patients: without
pathological changes within the boundaries of the periodontium and in the case of
patients endangered with the occurrence of gingivitis caused by dental plaque. ©
Copyright by Wroclaw Medical University.
AN - rayyan-563560562
AU - Tanasiewicz, M.
AU - Skucha-Nowak, M.
AU - Dawiec, M.
AU - Król, W.
AU - Skaba, D.
AU - Twardawa, H.
IS - 1
KW - alcohol
propolis
toothpaste
adult
article
controlled study
female
follow up
gingivitis
human
hygiene product
male
mouth cavity
mouth hygiene
periodontitis
tooth plaque
LA - English
PY - 2012
SN - 1899-5276
SP - 81-92
ST - Influence of hygienic preparations with a 3% content of ethanol extract of
brazilian propolis on the state of the oral cavity
T2 - Adv. Clin. Exp. Med.
TI - Influence of hygienic preparations with a 3% content of ethanol extract of
brazilian propolis on the state of the oral cavity
VL - 21
ID - 13936
ER -
TY - JOUR
AB - OBJECTIVE: The present study was conducted to evaluate the presence of
aerobic bacteria, anaerobic bacteria, E. faecalis, F. nucleatum, Propionibacteria
sp., Actinomyces sp., and their reduction at various stages of endodontic
retreatment with the use of conventional protocol (5.25 % Sodium Hypochlorite
(NaOCl) as the irrigant along with Calcium Hydroxide (Ca (OH)2) as intracanal
medicament and advocated protocol (SmearOFF as the irrigant along with 2%
Chlorhexidine (CHX) gel as intracanal medicament). METHODS: Twenty eight patients
fulfilling the eligibility criteria were selected for root canal retreatment and
randomly allocated into two groups. Group 1: Final irrigant as
SmearOFF+Chlorhexidine 2% gelas intracanal medicament (n=14). Group 2: Final
irrigant as 5.25% NaOCl+Ca(OH)2 as intracanal medicament (n=14). With aseptic
environment, access opening was performed followed by Gutta Percha (GP) removal and
sample S1 was collected for bacterial analysis. The biomechanical preparation was
done by using Reciproc system with additional finishing with XP-Endo Finisher R.
Sample S2 was then collected for bacterial analysis after the final irrigation
protocol in the respective groups. Intracanal medicaments were placed for one week
and sample S3 was collected. All the samples were subjected to qualitative analysis
using PCR and quantification was done by Colony Forming Unit (CFU) analysis.
RESULTS: Aerobic [28/28], Anaerobic [28/28], Propionibacterium sp. [20/28] and F.
nucleatum [24/28] were the most frequently isolated in S1 sample followed by
Actinomyces sp. [16/28] and E. faecalis sp. [19/28]. Chemico-mechanical preparation
followed by irrigation (S2 sample) resulted in significant reduction of all types
of bacteria in both groups. Group-1 (SmearOFF as the final irrigant) had
significantly superior efficacy against aerobic bacteria, E. faecalis and F.
nucleatum (P<0.05) as compared to Group-2 (NaOCl). After medicament placement,
significant differences between the groups were noted only for the E. Faecalis
group. For the S3 samples, the mean bacterial reduction was significant in Aerobic
and F. nucleatum in S3 samples for Group 1 and Group 2. CONCLUSION: Chemico-
mechanical preparation followed by irrigation resulted in significant reduction in
bacterial load irrespective of the final irrigant. SmearOFF was significantly
better than NaOCl in minimizing bacterial load of E. faecalis and F. nucleatum. 2%
Chlorhexidine gel has superior antimicrobial efficacy against E. faecalis and may
be recommended in secondary endodontic treatment.
AN - rayyan-563561383
AU - Tandon, J.
AU - Taneja, S.
AU - Bhalla, V. K.
AU - Jain, A.
DO - 10.14744/eej.2022.42713
IS - 3
J2 - Eur Endod J
KW - Actinomyces
Bacteria
Calcium Hydroxide/pharmacology
Dental Pulp Cavity
Disinfection
Gutta-Percha
Humans
*Periapical Periodontitis/therapy
Retreatment
*Root Canal Irrigants/pharmacology
Sodium Hypochlorite/pharmacology
LA - eng
N1 - Department of Conservative Dentistry and Endodontics, ITS Centre for dental
studies and Research, Uttar Pradesh, India.; Department of Conservative Dentistry
and Endodontics, ITS Centre for dental studies and Research, Uttar Pradesh, India.;
Department of Conservative Dentistry and Endodontics, ITS Centre for dental studies
and Research, Uttar Pradesh, India.; Department of Oral Pathology, ITS centre for
dental studies and Research, Uttar Pradesh, India.
PY - 2022
SP - 210-216
ST - Evaluation of Bacterial Reduction at Various Stages of Endodontic Retreatment
After Use of Different Disinfection Regimens: An In Vivo Study
T2 - European endodontic journal
TI - Evaluation of Bacterial Reduction at Various Stages of Endodontic Retreatment
After Use of Different Disinfection Regimens: An In Vivo Study
VL - 7
Y2 - 10
ID - 14757
ER -
TY - JOUR
AB - Chitin is a natural polymeric polysaccharide extracted from marine
crustaceans, and chitosan is obtained by removing part of the acetyl group (usually
more than 60 %) in chitin's structure. Chitosan has attracted wide attention from
researchers worldwide due to its good biodegradability, biocompatibility,
hypoallergenic and biological activities (antibacterial, immune and antitumor
activities). However, research has shown that chitosan does not melt or dissolve in
water, alkaline solutions and general organic solvents, which greatly limits its
application range. Therefore, researchers have carried out extensive and in-depth
chemical modification of chitosan and prepared a variety of chitosan derivatives,
which have expanded the application field of chitosan. Among them, the most
extensive research has been conducted in the pharmaceutical field. This paper
summarizes the application of chitosan and chitosan derivatives in medical
materials over the past five years.
AN - rayyan-563559702
AU - Tang, W.
AU - Wang, J.
AU - Hou, H.
AU - Li, Y.
AU - Fu, J.
AU - Lu, L.
AU - Gao, D.
AU - Liu, Z.
AU - Zhao, F.
AU - Gao, X.
AU - Ling, P.
AU - Wang, F.
AU - Sun, F.
AU - Tan, H.
DO - 10.1016/j.ijbiomac.2023.124398
KW - bone tissue engineering scaffold
cartilage tissue engineering scaffold
corneal tissue engineering scaffold
film
neural tissue engineering scaffold
skin tissue engineering scaffold
suture
tissue scaffold
tracheal tissue engineering scaffold
wound dressing
adsorbent
chitosan
chitosan aerogel
chitosan derivative
chitosan fiber
chitosan hydrogel
chitosan nanofiber
chitosan sponge
drug carrier
hemostatic agent
molecular scaffold
tissue adhesive
unclassified drug
acylation
alkylation
angiogenesis
biocompatibility
biodegradability
biomedicine
bone regeneration
bone remodeling
carboxylation
cell adhesion
cell proliferation
chemical reaction
coating (procedure)
dental caries
dental procedure
dental restoration
encapsulation
hemostasis
human
hydrophobicity
periodontitis
phosphorylation
polymerization
quaternization
review
sulfonation
thiolation
tissue engineering
water solubility
LA - English
PY - 2023
SN - ["1879-0003", "0141-8130"]
ST - Review: Application of chitosan and its derivatives in medical materials
TI - Review: Application of chitosan and its derivatives in medical materials
VL - 240
ID - 13076
ER -
TY - JOUR
AB - OBJECTIVE: To evaluate the effects of local-delivery of 25% metronidazol gel
and mechanical cleaning using ultrasonic carbon fiber tip on dental implants with
peri-implantitis. METHODS: 27 implants with peri-implantitis were randomly assigned
to receiving either 25% metronidazol gel treatment or carbon fiber tip ultrasonic
scaling. All parameters including plaque index (PLI), probing depth (PD) of pocket,
sulcular bleeding index (SBI), and BANA enzyme analysis were measured at baseline,
1, 2, 6 and 12 weeks after treatment. RESULTS: Statistically significant decrease
(P < 0.05) in SBI, BANA test and PLI occurred in both treatment groups at all time
intervals compared to baseline. PD had a decreasing tendency in both groups, but
only metronidazole group reached statistically significant level (P < 0.05) at 2
and 6 week intervals compared to baseline. None of the treatment modalities
produced any side effects on the implant and peri-implant tissues. CONCLUSIONS:
Both 25% metronidazol gel and mechanical cleaning using ultrasonic carbon fiber tip
can be safely and effectively used in the treatment of peri-implant diseases.
AN - rayyan-563560906
AU - Tang, Z.
AU - Cao, C.
AU - Sha, Y.
AU - Lin, Y.
AU - Wang, X.
IS - 3
carbon
metronidazole
adult
article
clinical trial
controlled study
female
human
male
microbiology
middle aged
periodontitis
time
tooth implantation
treatment outcome
ultrasound
LA - English
PY - 2002
SN - 1002-0098
SP - 173-175
ST - Effects of non-surgical treatment modalities on peri-implantitis
TI - Effects of non-surgical treatment modalities on peri-implantitis
VL - 37
ID - 14280
ER -
TY - JOUR
AB - The extracellular antigens of Actinobacillus actinomycetemcomitans Y4
(serotype b) contain a 37-kDa protein which is a major target for IgGs from
patients suffering from severe alveolar bone loss. Since the 37-kDa protein has not
been studied sufficiently, our investigation focused on its characteristics, e.g.,
its localization, specificity, and whether it directly stimulates macrophages to
produce cytokines. The 37-kDa protein was purified from the culture supernatant of
the Y4 strain by means of chromatofocusing and gel filtration. The 37-kDa protein
is a unique glycoprotein which forms immune complexes with monoclonal antibodies
against rhamnose-fucose polysaccharide. Patients with A. actinomycetemcomitans-
associated periodontitis had higher antibody titers to the purified 37-kDa protein
than healthy subjects (p < 0.001). Anti-37-kDa protein antibodies recognized a 37-
kDa band in the cytosolic, ribosomal, and total membrane fractions from Y4 cells.
Extracellular substances from other strains of A. actinomycetemcomitans (serotypes
a and c) also reacted in the Western blots, but Haemophilus spp. or several
periodontopathic bacteria did not. These results suggested that the 37-kDa protein
is a cytosolic protein that is passed through the cell membrane, and its protein
portion is specific for A. actinomycetemcomitans but common to serotypes. This
protein induced Il-1 beta, Il-6, and TNF-alpha release from murine macrophages. The
Il-6-inducing activity of the 37-kDa protein was higher than that of LPS. These
findings suggested that the 37-kDa protein which is released from live cells plays
a role in A. actinomycetemcomitans-associated periodontitis, as antigen inducing
the release of inflammatory cytokines which are associated with alveolar bone loss.
AN - rayyan-563561039
AU - Tani, Y.
AU - Tani, M.
AU - Kato, I.
IS - 9
KW - bacterial antigen
bacterium antibody
epitope
fucose
immunoglobulin G
interleukin 1
interleukin 6
lipopolysaccharide
membrane antigen
membrane protein
monoclonal antibody
polysaccharide
rhamnose
animal
antigen antibody complex
article
Bagg albino mouse
biosynthesis
cell membrane
classification
cytosol
female
Haemophilus
immunology
isoelectric focusing
macrophage
microbiology
molecular weight
mouse
osteolysis
periodontitis
ribosome
serotyping
Western blotting
LA - English
PY - 1997
SN - 0022-0345
SP - 1538-1547
ST - Extracellular 37-kDa antigenic protein from Actinobacillus
actinomycetemcomitans induces TNF-alpha, IL-1 beta, and IL-6 in murine macrophages
T2 - J. Dent. Res.
TI - Extracellular 37-kDa antigenic protein from Actinobacillus
actinomycetemcomitans induces TNF-alpha, IL-1 beta, and IL-6 in murine macrophages
VL - 76
ID - 14413
ER -
TY - JOUR
AB - Periodontitis comprises a chronic inflammation that is initiated by
microbiota biofilm. If left untreated, periodontitis may lead to permanent tooth
loss. Herein, we propose to design and improve a localized form of therapy
comprising a chlorhexidine-impregnated hydrogel. Hydrogel films were prepared by
varying the ratio between cellulose (MCC) and carboxymethylcellulose sodium (CMC)
using the crosslinker epichlorohydrin (ECH). The hydrogel was loaded with
chlorhexidine. Increasing the CMC ratio led to a reduction in the number of pores,
an increase in their size, lower glass transition temperature (Tg), decreased
Young's modulus, and increased film stretching and affected the time of release.
Bacterial and fungal zones of inhibition showed similar activity and were not
affected by the CMC and MCC ratio. Hydrogels loaded with chlorhexidine prevented
the growth of S. oralis and C. albicans microorganisms and may provide a promising
local delivery system for treating periodontitis.
AN - rayyan-563560053
AU - Tarawneh, O.
AU - Hamadneh, I.
AU - Huwaitat, R.
AU - Al-Assi, A. R.
AU - El Madani, A.
DO - 10.1155/2021/9853977
KW - carboxymethylcellulose
cellulose
chlorhexidine
epichlorohydrin
hydrogel
article
Candida albicans
controlled study
cross linking
fungus growth
glass transition temperature
nonhuman
periodontitis
pore size
Young modulus
LA - English
PY - 2021
SN - ["2314-6141", "2314-6133"]
ST - Characterization of Chlorhexidine-Impregnated Cellulose-Based Hydrogel Films
Intended for the Treatment of Periodontitis
TI - Characterization of Chlorhexidine-Impregnated Cellulose-Based Hydrogel Films
Intended for the Treatment of Periodontitis
VL - 2021
ID - 13427
ER -
TY - JOUR
AB - The fibula microvascular free flap technique and placement of dental
endosseous implants seem to be viable options for reconstructing the mandible,
following a resective jaw surgery. The causes of early failures of implants include
bone overheating, latent infection by surgical trauma, the factors related with the
implant, and overcompression. This case report reviews the mechanisms of early
post-implantation bone loss, and suggests the course of treatment for early peri-
implantitis for implants that show no mobility. Radiographs and clinical data
presented have shown that the surgical treatment of early developed peri-
implantitis using GBR methods in free fibula graft sites offers promising and
stabile results.
AN - rayyan-563560019
AU - Tatić, Z.
AU - Bubalo, M.
AU - Petrović, N.
AU - Konstantinović, V.
AU - Milović, R.
DO - 10.15644/asc55/1/8
IS - 1
KW - bone prosthesis
dental laser
nasogastric tube
tooth implant
Water lase Express
amoxicillin
collagen gel
metal ceramic alloy
polymacon
sodium chloride
ubiste forte
unclassified drug
adult
anastomosis
autograft
bone density
bone regeneration
case report
clinical article
clinical feature
clinical protocol
fibula graft
follow up
gingivitis
granulation tissue
human
male
mandibulectomy
middle aged
myxoma
osteolysis
osteotomy
periimplantitis
postoperative hemorrhage
review
surgical debridement
surgical injury
treatment outcome
X ray
LA - ["English", "Croatian"]
PY - 2021
SN - ["1846-0410", "0001-7019"]
SP - 69-75
ST - Treatment of early developed peri-implantitis in fibula graft site
T2 - Liječenje ranoga periimplantitisa u presatku fibule
TI - Treatment of early developed peri-implantitis in fibula graft site
VL - 55
ID - 13393
ER -
TY - BOOK
AN - rayyan-563561840
AU - Tayebi, L.
DO - 10.1007/978-3-030-21583-5
PY - 2019
SP - 1-474
ST - Applications of Biomedical Engineering in Dentistry
T2 - Applications of Biomedical Engineering in Dentistry
TI - Applications of Biomedical Engineering in Dentistry
85149097505&doi=10.1007%2f978-3-030-21583-
5&partnerID=40&md5=4e1b8addc686e90c706d8464e446d197
ID - 15214
ER -
TY - JOUR
AN - rayyan-563561061
AU - Taylor, T.
AU - McVittie, L.
AU - Croteau, D.
IS - 4
KW - metronidazole
clinical trial
human
periodontitis
short survey
LA - English
PY - 1996
SN - 0008-4123
SP - 223-225
ST - Local metronidazole gel treatment for periodontal disease
T2 - CAN. J. HOSP. PHARM.
TI - Local metronidazole gel treatment for periodontal disease
VL - 49
ID - 14435
ER -
TY - JOUR
AB - Objective: To investigate putative salivary biomarkers for screening and
diagnosis of type 2 diabetes mellitus and diabetic nephropathy. Design: Saliva and
serum samples were collected from 29 patients with type 2 diabetes, 20 patients
with diabetic nephropathy, eight patients with non-diabetic induced nephropathy,
and 25 healthy subjects. Initially, pooled unstimulated saliva samples from six
sex- and age-matched healthy subjects and six patients with type 2 diabetes were
subjected to two-dimensional gel electrophoresis, followed by mass spectrometry.
Protein expression of cystatin SA in the saliva of patients with type 2 diabetes
was further examined in saliva and serum using enzyme-linked immunosorbent assay
(ELISA). Results: Two-dimensional gel electrophoresis revealed upregulation of
salivary cystatin SA in patients with type 2 diabetes. ELISA showed a weak trend of
increasing salivary cystatin SA levels in patients with type 2 diabetes, compared
with those levels in healthy subjects. When patients were stratified according to
periodontal status, linear regression analyses revealed that salivary cystatin SA
levels were associated with Periodontal Screening and Recording (PSR) index (beta =
0.297, p < 0.05) when the analysis was adjusted for age, sex, HbA(1C), estimated
glomerular filtration rate (eGFR), and number of teeth. Serum cystatin SA levels
were negatively associated with eGFR (beta = -0.534, p < 0.0001) when the analysis
was adjusted for age, sex, HbA(1C), number of teeth, and PSR index. Conclusions:
Salivary cystatin SA was associated with periodontal disease severity; moreover,
serum cystatin SA levels could reflect kidney function.
AN - rayyan-563562530
AU - Techatanawat, S.
AU - Surarit, R.
AU - Chairatvit, K.
AU - Roytrakul, S.
AU - Khovidhunkit, W.
AU - Thanakun, S.
AU - Izumi, Y.
AU - Khovidhunkit, S. O. P.
DO - 10.1016/j.archoralbio.2019.05.020
PY - 2019
SN - ["0003-9969", "1879-1506"]
SP - 67-75
ST - Salivary and serum cystatin SA levels in patients with type 2 diabetes
mellitus or diabetic nephropathy
TI - Salivary and serum cystatin SA levels in patients with type 2 diabetes
mellitus or diabetic nephropathy
VL - 104
Y2 - 8
ID - 15904
ER -
TY - JOUR
AB - INTRODUCTION: This Consolidated Standards of Reporting Trials randomized
clinical trial investigated T helper (Th1, Th2, Th9, Th17, and Tfh) and regulatory
T (Treg) cell-type cytokines and their networks in apical periodontitis (AP). We
also assessed the effects of calcium hydroxide [Ca(OH)2] intracanal medications
(ICMs) on helper T and Treg cell-type cytokines. METHODS: Twenty teeth with primary
endodontic infection and apical periodontitis were randomly divided into two
groups: Ca(OH)2 + saline solution (n = 10) and Ca (OH)2 + 2% chlorhexidine-gel (n =
10). Samples were collected from the periradicular tissue fluid (PTF) before
(PTFs1) and after 14 days of ICMs (PTFs2). The Human High Sensitivity T Cell Panel
was used to quantify target T-helper (Th)1: interelukin (IL)-2, IL-12, and
interferon-gamma (IFN-γ); Th2: IL-4, IL-5, and IL-13; Th9: IL-9; Th17: IL-17; T
follicular helper cells (Tfh): IL-21; and Treg-cell-type cytokine: IL-10. RESULTS:
Th1-type cytokines were higher than Th2-type ones, at PTFs1. Positive (+)
associations were found among all Th1-type cytokines and all Th2-type cytokines.
There were negative (-) correlations between all Th1- and Th2-type cytokines. Size
of radiolucent lesions and symptoms (tenderness to percussion and/or pain on
palpation) were positively correlated with Th1-type cytokines, IL-17, and IL-21 but
negatively correlated with Th2-type cytokines and IL-10 (all, P < .001). Both ICMs
increased Th2-type cytokines and IL-10 (P < .05) and decreased Th1-type cytokines,
IL-17, and IL-21 (P < .05), with no differences among them (P > .05). CONCLUSIONS:
Complex T-cell cytokine networks are involved in AP. Both Ca(OH)2 ICMs effectively
increased IL-4, IL-5, IL-10, and IL-13 and lowered IL-2, IL-12, IL-17, IL-21, and
IFN-γ.
AN - rayyan-563559819
AU - Teixeira, F. F. C.
AU - Cardoso, F. G. R.
AU - Ferreira, N. S.
AU - Valera, M. M. C.
DO - 10.1016/j.joen.2022.04.010
IS - 8
cytokine
gamma interferon
interleukin 10
interleukin 12
interleukin 13
interleukin 17
interleukin 4
interleukin 5
controlled study
human
Tfh cell
Th1 cell
Th17 cell
Th2 cell
LA - English
PY - 2022
SN - 1878-3554
SP - 975-984
ST - Effects of Calcium Hydroxide Intracanal Medications on T Helper (Th1, Th2,
Th9, Th17, and Tfh) and Regulatory T (Treg) Cell Cytokines in Apical Periodontitis:
A CONSORT RCT
T2 - J Endod
TI - Effects of Calcium Hydroxide Intracanal Medications on T Helper (Th1, Th2,
Th9, Th17, and Tfh) and Regulatory T (Treg) Cell Cytokines in Apical Periodontitis:
A CONSORT RCT
VL - 48
ID - 13193
ER -
TY - JOUR
AN - rayyan-563561942
AU - Teles, A. M.
AU - Conceição Manso, M.
AU - Pina, C.
AU - Cabeda, J.
DO - 10.1016/j.rpemd.2014.02.002
IS - 2
PY - 2014
SP - 89-96
ST - In vivo evaluation of microbial reduction after chemo-mechanical preparation
of necrotic root canals with or without apical periodontitis
T2 - Revista Portuguesa de Estomatologia, Medicina Dentaria e Cirurgia
Maxilofacial
TI - In vivo evaluation of microbial reduction after chemo-mechanical preparation
84904696796&doi=10.1016%2fj.rpemd.2014.02.002&partnerID=40&md5=55ffc3560efca4710a97
f39cdbb36713
VL - 55
ID - 15316
ER -
TY - JOUR
AB - Objectives: Assessment of bacterial reduction after chemo-mechanical
preparation (using 3% sodium hypochlorite) with or without intracanal dressing
(calcium hydroxide paste (Ca(OH)2) or 2% chlorhexidine digluconate gel (CHX)) in
necrotic pulps associated or not with apical lesion. Methods: Prospective clinical
trial, in 69 adult patient's teeth with pulpal necrosis associated or not with
apical periodontitis. Microbiological root-canal-sampling occurred before treatment
(S1), after chemo-mechanical preparation (S2) and after 14 days intracanal dressing
(S3). Colony Forming Units (CFU) were counted after growth in aerobic, anaerobic
and microaerofilic cultures. Comparison of the median CFUs treatments and culture
media was done with the Friedman test. Comparison of the intracanal dressing effect
at S3 was done with the Wilcoxon and the Mann-Whitney tests. Because of the huge
differences in bacterial counts variations were expressed as log. 10 to analyze
differences among intracanal medication groups. S2 and S3 counts were expressed as
percentage of CFU reduction regarding S1 counts. Results: Significant differences
were detected between S1, S2 and S3 (Friedman test; p<0.001), showing a significant
decrease from S1 to S2 (Wilcoxon test; p<0.004), followed by a significant increase
from S2 to S3 (p<0.001) for the CHX group, maintenance for the Ca(OH)2 group in
aerobic/anaerobic (Wilcoxon test; p=0.777/0.227), and increase in the
microaerofilic culture (Wilcoxon test; p=0.047). The two groups only differed
significantly in S3 (Mann-Whitney test; p≤0.001), with a worse performance in the
CHX group. Conclusions: Treatment significantly reduced the number of bacteria but
failed to render all root canals sterile. Ca(OH)2 performed better than CHX gel. ©
2013 Sociedade Portuguesa de Estomatologia e Medicina Dentária.
AN - rayyan-563560450
AU - Teles, A. M.
AU - Conceição Manso, M.
AU - Pina, C.
AU - Cabeda, J.
DO - 10.1016/j.rpemd.2014.02.002
IS - 2
hypochlorite sodium
root canal dressing
adult
article
bacterial count
bacterium detection
controlled study
culture medium
disease association
female
Friedman test
human
male
necrosis
priority journal
tooth pulp
tooth pulp disease
tooth root canal
LA - English
PY - 2014
SN - ["1647-6700", "1646-2890"]
SP - 89-96
T2 - Rev. Port. Estomatol. Med. Dent. Cir. Maxilofac.
VL - 55
ID - 13824
ER -
TY - JOUR
AB - AimTo quantify bacterial equivalents before and after chemomechanical
preparation using 3% sodium hypochlorite (NaOCl) and intracanal dressing with
calcium hydroxide paste (Ca(OH)(2)) or 2% Chlorhexidine digluconate gel (CHX) in
necrotic pulps associated or not with apical periodontitis and to further compare
this quantification with counts of anaerobic microorganisms. MethodologyProspective
clinical trial in 69 single-rooted adult teeth (strict inclusion criteria); CHX
group: 34; Ca(OH)(2) group: 35. Bacteria samples were taken at baseline (S1), after
chemomechanical preparation (S2) and after 14days of intracanal dressing (S3).
Bacterial equivalents were assessed by broad-range real-time polymerase chain
reaction (qPCR), and live viable bacteria measured with conventional anaerobic
culture (CFU/mL). Descriptive/inferential analysis was performed with spss vs. 20.0
(=0.05) using the Kruskal-Wallis, Mann-Whitney and chi-squared tests and Spearman's
correlation coefficients. ResultsBoth groups showed a significant decrease between
S1 and S2 (Mann-Whitney U-test; P<0.001) both in qPCR and in culture. In the Ca(OH)
(2)-group, no variation was observed between S2 and S3 by qPCR and culture. In
contrast, the CHX group showed a significant increase from S2 to S3 by both
techniques. The two groups were only significantly different in S3 (Mann-Whitney U-
test; P0.001), with a worse performance in the CHX group. Again, these results were
congruent by both approaches. Data from both approaches correlate reasonably
(r(S)<0.5). ConclusionsInfected root canals contained a high bacterial load, and
the chemomechanical root canal preparation reduced bacterial equivalents by 99.1%
and anaerobic counts by 98.5%. Intracanal dressings were not efficient at reducing
bacterial load, but the 14-day intracanal dressing with Ca(OH)(2) performed
significantly better than CHX, particularly in cases with apical periodontitis.
AN - rayyan-563562549
AU - Teles, A. M.
AU - Manso, M. C.
AU - Loureiro, S.
AU - Silva, R.
AU - Madeira, I. G. C.
AU - Pina, C.
AU - Cabeda, J. M.
DO - 10.1111/iej.12122
IS - 1
PY - 2014
SN - ["0143-2885", "1365-2591"]
SP - 32-40
ST - Effectiveness of two intracanal dressings in adult Portuguese patients: a
qPCR and anaerobic culture assessment
TI - Effectiveness of two intracanal dressings in adult Portuguese patients: a
qPCR and anaerobic culture assessment
VL - 47
Y2 - 1
ID - 15923
ER -
TY - JOUR
AB - Collagenolytic enzymes released by neutrophils are associated with the
destruction of periodontium in periodontal diseases. Measurement of these enzymes
in gingival crevicular fluid (GCF) could be used to test for periodontal diseases
and thereby simplify diagnosis. To test this hypothesis, gelatinase (MMP-9) was
analyzed in GCF samples with a simple assay system. GCF was collected by a
mouthrinse method from 10 patients with gingivitis (G); 10 well-treated and
maintained periodontitis patients (TP) without detectable loss of attachment; and 9
patients with recurrent loss of periodontal attachment (greater than 2 mm) and/or
abscess formation (RP). Clinical measurements including tooth mobility (MOB) and
gingival attachment level (GAL) were made monthly for a maximum of 10 months.
Active and latent forms of gelatinase were measured by a functional assay using
gelatin substrate-gel enzymography and the activities were quantified by laser
densitometry. Reproducibility analysis demonstrated that the assay (inter-gel,
inter-assay, inter-scan) and diurnal variations were small compared to biological
variation. The presence of active gelatinase was detected in 97.8% of TP samples,
86.4% of RP samples, but in only 11.4% of G samples. In addition, the mean active
gelatinase activity was found to be significantly higher (p less than 0.001) in the
RP (71,006 U) than the TP (43,814 U) groups, both of which were higher (p less than
0.001) than the G group (2824 U). During periods of attachment loss, samples from
the RP group exhibited a 2-fold increase of mean active gelatinase activity
(129,414 U).(ABSTRACT TRUNCATED AT 250 WORDS)
AN - rayyan-563561152
AU - Teng, Y. T.
AU - Sodek, J.
AU - McCulloch, C. A.
DO - 10.1111/j.1600-0765.1992.tb01830.x
IS - 5
collagenase
gelatinase B
metronidazole
adult
aged
article
enzyme assay
enzymology
female
gingivitis
human
male
middle aged
periodontal disease
periodontics
periodontitis
regression analysis
reproducibility
LA - English
PY - 1992
SN - 0022-3484
SP - 544-552
ST - Gingival crevicular fluid gelatinase and its relationship to periodontal
disease in human subjects
TI - Gingival crevicular fluid gelatinase and its relationship to periodontal
disease in human subjects
VL - 27
ID - 14526
ER -
TY - JOUR
AB - Background: A large number of trials has been conducted using curcumin as the
main ingredient in mouth rinses, topical oral gel, subgingival irrigant, locally
delivered gel and locally delivered chips to reduce gingival inflammation and
probing pocket depth. However, the results of these trials vary and are debatable.
Objective: To evaluate the effectiveness of oral curcumin products as compared to
the routinely used ones in reducing gingival inflammation and probing pocket depth
in adults. Methods: Electronic databases such as Pubmed/Medline and Cochrane
Library and hand searching was done for randomised controlled trials (RCTs), which
yielded 148 results, of which 27 RCTs compared curcumin products with routinely
used ones. Meta-analysis was conducted to check for plaque reduction, gingival
inflammation and pocket depth. Results: 963 participants in the 27 RCT studies were
considered for a systematic review. We found that for a long-term evaluation of
probing pocket depth in nine studies each with 400 participants, there was a
statistically significant difference in the reduction when curcumin topical gel was
used as compared with the control [SMD −0.87, 95% CI: −1.31 to −0.43]. However, in
the evaluation of short-term plaque and gingival scores, we found no statistically
significant differences in the reduction when curcumin mouth rinse was used [SMD
−0.76, 95% CI: −2.25 to 0.73] and [MD: −0.09, 95% CI: −0.29 to 0.10]. Conclusion:
Curcumin topical and local delivery gel, mouth rinses and sub-gingival irrigants
were found to be equally effective compared to the routinely used agents for
reduction of plaque and gingival inflammation. Curcumin local delivery gel had
greater reduction in probing pocket depth.
AN - rayyan-563559945
AU - Terby, S.
AU - Shereef, M.
AU - Ramanarayanan, V.
AU - Balakrishnan, B.
DO - 10.1016/j.sdentj.2021.07.008
IS - 7
KW - chlorhexidine
curcumin
gel
glycerol
metronidazole
mouthwash
ornidazole
turmeric
adult
clinical outcome
Cochrane Library
Curcuma longa
dental scaling
gingival index
gingivitis
human
information retrieval
lavage
Medline
meta analysis
outcome assessment
plaque index
review
root planing
subgingival irrigation
systematic review
tooth plaque
topical treatment
LA - English
PY - 2021
SN - 1013-9052
SP - 375-385
ST - The effect of curcumin as an adjunct in the treatment of chronic
periodontitis: A systematic review and meta-analysis
T2 - Saudi Dent. J.
TI - The effect of curcumin as an adjunct in the treatment of chronic
periodontitis: A systematic review and meta-analysis
VL - 33
ID - 13319
ER -
TY - JOUR
AB - During earlier examination of interleukin-1 (IL-1)-induced matrix
metalloproteinase gene expression in human gingival fibroblasts a highly induced
immediate early gene, IκB-α, a NFκB DNA-binding inhibitor, was identified. The aim
now was to investigate whether recombinant (r)IL-1β induces the stimulation of NFκB
and its inhibitor proteins in human gingival fibroblasts and to understand if
inhibition of its activity affects collagenase gene expression. Primary gingival
fibroblasts (human) were treated with rIL-1β to determine the effect on NFκB-like
DNA-binding activity. IL-1 induced the production of steady-state mRNA levels of
IκB-α in the cultured fibroblasts. Nuclear run-on transcription studies
demonstrated that rIL-1 induction of IκB-α may be transcriptionally regulated.
Using electrophoretic mobility gel-shift assays it was shown that rIL-1 activates
NFκB-like DNA-binding activity in these fibroblasts. NFκB- like DNA-binding
activity was rapidly induced and turned over in gingival fibroblasts with peak
activity at 30 min after rIL-1 treatment. Further, treatment with chymotrypsin
protease inhibitor and antioxidant inhibitor prevented IL-1-induced, NFκB-like,
DNA-binding activity and collagenase mRNA production. When coupled with the
existence of NFκB consensus DNA-binding sites on the collagenase gene promoter,
these findings suggest that the stimulation of NFκB in gingival fibroblasts by rIL-
1 could play an important part in the regulation of their collagenase gene
expression. The ability of IL-1 to stimulate this expression may define a pivotal
role for this cytokine in the pathogenesis of periodontitis.
AN - rayyan-563561064
AU - Tewari, M.
AU - Tuncay, O. C.
AU - Milchman, A.
AU - Reddy, P. J.
AU - Reddy, C. D.
AU - Cressman, D. E.
AU - Taub, R.
AU - Newton, R. C.
AU - Tewari, D. S.
DO - 10.1016/0003-9969(96)00148-3
IS - 5
KW - chymotrypsin
collagenase
cycloheximide
cytokine
DNA
DNA binding protein
interleukin 1
messenger RNA
metalloproteinase
oxidizing agent
recombinant interleukin 1beta
recombinant protein
RNA
tosylphenylalanyl chloromethyl ketone
article
cell culture
chromosome map
consensus sequence
controlled study
cytology
DNA binding
fibroblast
fibroblast culture
gene expression
genetics
gingiva
human
human cell
immediate early gene
metabolism
periodontitis
promoter region
LA - English
PY - 1996
SN - 0003-9969
SP - 461-468
ST - Association of interleukin-1-induced, NFκB DNA-binding activity with
collagenase gene expression in human gingival fibroblasts
T2 - ARCH. ORAL BIOL.
TI - Association of interleukin-1-induced, NFκB DNA-binding activity with
collagenase gene expression in human gingival fibroblasts
VL - 41
ID - 14438
ER -
TY - JOUR
AB - Background: Virgin Coconut Oil (VCO) is a vegetable oil extracted from
coconut fleshcontains unsaturated fatty acids in the form of oleic acid and
linoleic acid and flavonoids which function as anti-inflammatory. Periodontitis is
an inflammatory disease of the periodontal tissues with a high prevalence
worldwide. The main etiology of plaque periodontitis is biofilm containing colonies
of pathogenic microorganisms. The occurrence of inflammation in the periodontal
tissue stimulates the release of inflammatory mediators such as Interleukin-1β (IL-
1β) and Interleukin-6 (IL-6). Treatment of periodontitis started from initial
therapy, and usually accompanied by additional therapy such as local drug
administration. VCO can be used as an alternative anti-inflammatory. Objectives is
to determine the effect of VCO as a local drug delivery in periodontal treatment
through analysis of IL-1β and IL-6. Methods: This is an experimental laboratory
with a posttest-only control group design. VCO is made from grated fresh coconut
and then mixed with NaCMC to get the consistency of the gel. The subjects of this
study were 24 male Wistar rats that were induced by periodontitis by injecting
Porphyromonas Gingivalis (P. Gingivalis) into the gingival sulcus. Wistar rats were
then divided into 3 groups. On the 7th and 14th day, the rats were sacrificed and
jaw samples were taken to determine the amount of IL-1β and IL-6 in the
regenerative process of the periodontal tissue. Results: The amount of IL-1β and
IL-6 decreased in all treatment groups, but not as big as the decrease in the VCO
group. Conclusion: VCO can reduce the amount of IL-1β and IL-6 in the treatment of
wistar rats periodontal tissue induced by P. gingivalis.
AN - rayyan-563559768
AU - Thahir, H.
AU - Djais, A. I.
AU - Nasir, M.
AU - Bachtiar, R.
AU - Pasangallo, A.
AU - Hatimurni
AU - Achmad, H.
DO - 10.47750/pnr.2023.14.S01.12
KW - microscope
coconut oil
gel
interleukin 1beta
interleukin 6
metronidazole
animal experiment
animal model
animal tissue
article
controlled study
gingiva
jaw
male
nonhuman
periodontal disease
periodontitis
rat
LA - English
PY - 2023
SN - ["2229-7723", "0976-9234"]
SP - 113-122
ST - EFFECTIVENESS OF VIRGIN COCONUT OIL IN PERIODONTAL TREATMENT VIA ANALYSIS OF
IL-1β AND IL-6
TI - EFFECTIVENESS OF VIRGIN COCONUT OIL IN PERIODONTAL TREATMENT VIA ANALYSIS OF
IL-1β AND IL-6
VL - 14
ID - 13142
ER -
TY - JOUR
AB - Background. Virgin coconut oil is a natural product from coconut that has
many benefits such as antibacterial, anti-inflammatory, and antioxidant.
Inflammatory disease of the periodontal tissues has a high prevalence worldwide.
The main etiology of periodontitis plaque of biofilm contains colonies of
pathogenic microorganisms. The occurrence of inflammation in the periodontal tissue
stimulates the release of inflammatory mediators, such as TNF-alpha and TGF-beta.
Treatment for periodontitis can be performed starting from initial therapy and
usually accompanied by additional therapy such as local drug delivery. VCO can be
used as an alternative to antibiotics. Objective. To determine the effectiveness of
VCO gel on periodontal tissue regeneration materials through the expression of TNF-
alpha and TGF-beta 1. Methods. This is an experimental laboratory with a posttest-
only control group design. VCO was made from grated fresh coconut and then mixed
with NaCMC to obtain gel viscosity. The subjects of this study were 30 male
periodontitis-induced Wistar rats by injecting Porphyromonas gingivalis into the
gingival sulcus. Wistar rats were then divided into 3 groups. On the 7th and 14th
days, the rats were sacrificed and the jaw was sampled to determine the amount of
TNF-alpha and TGF-beta 1 expression in the regenerative process of periodontal
tissue. Result. The amount of TNF-alpha and TGF-beta 1 increased significantly in
the treatment group, but not as much as the increase in the positive control and
negative control groups. Conclusion. VCO gel can affect the expression of TNF-alpha
and TGF-beta 1 in the regeneration process of periodontal tissue in periodontitis-
induced rats.
AN - rayyan-563562364
AU - Thahir, H.
AU - Djais, A. I.
AU - Nasir, M.
AU - Feblina, A. R.
AU - Annisa, A.
AU - Etriyani, N.
AU - Achmad, H.
DO - 10.1155/2022/7562608
PY - 2022
SN - ["1687-8787", "1687-8795"]
ST - Virgin Coconut Oil as a New Concept for Periodontal Tissue Regeneration via
Expressions of TNF-alpha and TGF-beta 1
T2 - INTERNATIONAL JOURNAL OF BIOMATERIALS
TI - Virgin Coconut Oil as a New Concept for Periodontal Tissue Regeneration via
Expressions of TNF-alpha and TGF-beta 1
VL - 2022
Y2 - 2 y3 - 8
ID - 15738
ER -
TY - JOUR
AB - Background. Virgin coconut oil is a natural product from coconut that has
stimulates the release of inflammatory mediators, such as TNF-α and TGF-β.
used as an alternative to antibiotics. Objective. To determine the effectiveness of
α and TGF-β1. Methods. This is an experimental laboratory with a posttest-only
control group design. VCO was made from grated fresh coconut and then mixed with
NaCMC to obtain gel viscosity. The subjects of this study were 30 male
TNF-α and TGF-β1 expression in the regenerative process of periodontal tissue.
Result. The amount of TNF-α and TGF-β1 increased significantly in the treatment
group, but not as much as the increase in the positive control and negative control
groups. Conclusion. VCO gel can affect the expression of TNF-α and TGF-β1 in the
regeneration process of periodontal tissue in periodontitis-induced rats.
AN - rayyan-563559915
AU - Thahir, H.
AU - Irawaty Djais, A.
AU - Nasir, M.
AU - Annisa, A.
AU - Etriyani, N.
AU - Achmad, H.
DO - 10.1155/2022/7562608
KW - caspase 3
coconut oil
animal experiment
animal model
animal tissue
article
biofilm
controlled study
gene expression
gingiva
male
microorganism
nonhuman
periodontitis
prevalence
protein expression
rat
tissue regeneration
viscosity
LA - English
PY - 2022
SN - ["1687-8795", "1687-8787"]
Expressions of TNF- α and TGF- β 1
T2 - Int. J. Biomater.
Expressions of TNF- α and TGF- β 1
VL - 2022
ID - 13289
ER -
TY - JOUR
AB - BACKGROUND: Virgin coconut oil is a natural product from coconut that has
stimulates the release of inflammatory mediators, such as TNF-α and TGF-β.
used as an alternative to antibiotics. OBJECTIVE: To determine the effectiveness of
α and TGF-β1. METHODS: This is an experimental laboratory with a posttest-only
control group design. VCO was made from grated fresh coconut and then mixed with
NaCMC to obtain gel viscosity. The subjects of this study were 30 male
TNF-α and TGF-β1 expression in the regenerative process of periodontal tissue.
RESULT: The amount of TNF-α and TGF-β1 increased significantly in the treatment
group, but not as much as the increase in the positive control and negative control
groups. CONCLUSION: VCO gel can affect the expression of TNF-α and TGF-β1 in the
regeneration process of periodontal tissue in periodontitis-induced rats.
AN - rayyan-563561287
AU - Thahir, H.
AU - Irawaty Djais, A.
AU - Nasir, M.
AU - Annisa, A.
AU - Etriyani, N.
AU - Achmad, H.
DO - 10.1155/2022/7562608
J2 - Int J Biomater
LA - eng
N1 - Department of Periodontics, Faculty of Dentistry, Hasanuddin University,
Makassar, Indonesia.; Department of Periodontics, Faculty of Dentistry, Hasanuddin
University, Makassar, Indonesia.; Department of Orthodontic, Faculty of Dentistry,
Hasanuddin University, Makassar, Indonesia.; Periodontology Specialist Dental
Educational Program, Faculty of Dentistry, Hasanuddin University, Makassar,
Indonesia.; Periodontology Specialist Dental Educational Program, Faculty of
Dentistry, Hasanuddin University, Makassar, Indonesia.; Periodontology Specialist
Dental Educational Program, Faculty of Dentistry, Hasanuddin University, Makassar,
Indonesia.; Department of Pediatric Dentistry, Faculty of Dentistry, Hasanuddin
University, Makassar, Indonesia.
PY - 2022
SN - 1687-8787 (Print)
SP - 7562608
Expressions of TNF-α and TGF-β1
T2 - International journal of biomaterials
Expressions of TNF-α and TGF-β1
VL - 2022
ID - 14661
ER -
TY - JOUR
AB - The purpose of this study was to evaluate the effect of erbium: yttrium-
aluminum-garnet (Er: YAG) laser (2.94 μm) irradiation on the removal of root
surface smear layer of extracted human teeth and to compare its efficacy with that
of citric acid, ethylenediamine tetra-acetic acid (EDTA), or a gel containing a
mixture of tetracycline hydrochloride (HCl) and citric acid, using scanning
electron microscopy (SEM). Thirty human dentin specimens were randomly divided into
six groups: G1 (control group), irrigated with 10 ml of physiologic saline
solution; G2, conditioned with 24% citric acid gel; G3, conditioned with 24% EDTA
gel; G4, conditioned with a 50% citric acid and tetracycline gel; G5, irradiated
with Er: YAG laser (47 mJ/10 Hz/5.8 J/cm 2/pulse); G6, irradiated with Er: YAG
laser (83 mJ/10 Hz/10.3 J/cm 2/pulse). Electron micrographs were obtained and
analyzed according to a rating system. Statistical analysis was conducted with
Kruskal-Wallis and Mann-Whitney tests (P<0.05). G1 was statistically different from
all the other groups; no statistically significant differences were observed
between the Er: YAG laser groups and those undergoing the other treatment
modalities. When the two Er: YAG laser groups were compared, the fluency of G6 was
statistically more effective in smear layer removal than the one used in G5 (Mann-
Whitney test, P<0.01). Root surfaces irradiated by Er: YAG laser had more irregular
contours than those treated by chemical agents. It can be concluded that all
treatment modalities were effective in smear layer removal. The results of our
study suggest that the Er: YAG laser can be safely used to condition diseased root
surfaces effectively. Furthermore, the effect of Er: YAG laser irradiation on root
surfaces should be evaluated in vivo so that its potential to enhance the healing
of periodontal tissues can be assessed. © Springer-Verlag London Limited 2009.
AN - rayyan-563560636
AU - Zezell, D. M.
AU - Garcia, V. G.
AU - Haypek, P.
AU - Nagata, M. J. H.
AU - De Almeida, J. M.
AU - De Paula Eduardo, C.
DO - 10.1007/s10103-009-0665-4
IS - 4
KW - chemical agent
citric acid
edetic acid
tetracycline
article
controlled study
dental laser etching
dentin
erbium YAG laser
human
human tissue
irradiation
outcome assessment
periodontics
priority journal
tooth extraction
tooth root
LA - English
PY - 2010
SN - 0268-8921
SP - 485-491
ST - Comparative analysis of root surface smear layer removal by different etching
modalities or erbium: Yttrium-aluminum-garnet laser irradiation. A scanning
electron microscopy study
T2 - Lasers Med. Sci.
TI - Comparative analysis of root surface smear layer removal by different etching
modalities or erbium: Yttrium-aluminum-garnet laser irradiation. A scanning
electron microscopy study
VL - 25
ID - 14010
ER -
TY - JOUR
AB - Periodontal disease is characterised by proteolytic processes involving
enzymes that are released by host immune cells and periodontal bacteria. These
enzymes, when detectable in whole saliva, may serve as valuable diagnostic markers
for disease states and progression. Because the substrate specificities of salivary
proteases in periodontal health and disease are poorly characterised, we probed
these activities using several relevant substrates: (i) gelatin and collagen type
IV; (ii) the Arg/Lys-rich human salivary substrate histatin-5; and (iii) a
histatin-derived synthetic analog benzyloxycarbonyl-Arg-Gly-Tyr-Arg-methyl cumaryl
amide (Z-RGYR-MCA). Substrate degradation was assessed in gel (zymography) and in
solution. Whole saliva supernatant enzyme activities directed at gelatin,
quantified from the 42 kDa, 92 kDa and 130 kDa bands in the zymograms, were 1.3,
1.4 and 2.0-fold higher, respectively, in the periodontal patient group (P < 0.01),
consistent with enhanced activities observed towards collagen type IV. On the other
hand, histatin 5 degraded equally fast in healthy and periodontal patients' whole
saliva supernatant samples (P > 0.10). Likewise, the hydrolysis rates of the Z-
RGYR-MCA substrate were the same in the healthy and periodontal patient groups (P >
0.10). In conclusion, gelatinolytic/collagenolytic activities but not trypsin-like
activities in human saliva differentiate health from periodontal disease and may
thus provide an adjuvant to diagnosis for monitoring disease activity. © 2013 John
Wiley & Sons A/S.
AN - rayyan-563560512
AU - Thomadaki, K.
AU - Bosch, J. A.
AU - Helmerhorst, E. J.
DO - 10.1111/odi.12069
IS - 8
KW - collagen type 4
gelatin
histatin 5
proteinase
adult
article
clinical article
controlled study
diagnostic value
enzyme activity
enzyme specificity
human
periodontitis
priority journal
protein degradation
protein hydrolysis
saliva
zymography
LA - English
PY - 2013
SN - ["1601-0825", "1354-523X"]
SP - 781-788
ST - The diagnostic potential of salivary protease activities in periodontal
health and disease
T2 - Oral Dis.
TI - The diagnostic potential of salivary protease activities in periodontal
health and disease
VL - 19
ID - 13886
ER -
TY - JOUR
AB - More than 700 bacterial species have been detected in the human oral cavity.
They form highly organized microbial communities and are responsible for many oral
infectious diseases, such as dental caries and periodontal disease. The prevention
and treatment of these diseases require a comprehensive knowledge of oral microbial
communities, which largely relies on culture-dependent methods to provide detailed
phenotypic and physiological analysis of these communities. However, most of the
currently available laboratory media can only selectively support the growth of a
limited number of bacterial species within these communities, and fail to sustain
the original oral microbial diversity. In this study, using denaturing gradient gel
electrophoresis (DGGE) as an index to systematically survey and analyse the
selectivity of commonly used laboratory media, we developed a new medium (SHI
medium) by combining the ingredients of several selected media that can support
different subpopulations within the original oral microbial community derived from
pooled saliva. DGGE and 454 pyrosequencing analysis showed that SHI medium was
capable of supporting a more diversified community with a microbial profile closer
to that of the original oral microbiota. Furthermore, 454 pyrosequencing revealed
that SHI medium supported the growth of many oral species that have not before been
cultured. Crystal violet assay and the confocal laser scanning microscope analysis
indicated that, compared with other media, SHI medium is able to support a more
complex saliva-derived biofilm with higher biomass yield and more diverse species.
This DGGE-guided method could also be used to develop novel media for other complex
microbial communities. © 2010 John Wiley & Sons AS.
AN - rayyan-563560628
AU - Tian, Y.
AU - He, X.
AU - Torralba, M.
AU - Yooseph, S.
AU - Nelson, K. E.
AU - Lux, R.
AU - McLean, J. S.
AU - Yu, G.
AU - Shi, W.
DO - 10.1111/j.2041-1014.2010.00585.x
IS - 5
KW - crystal violet
adult
article
biomass
biomass support
comparative study
culture medium
gene sequence
genetic variability
human
image analysis
microbial community
microbial growth
mouth flora
mouth infection
nonhuman
normal human
nucleotide sequence
saliva
saliva analysis
SHI medium
stereochemistry
LA - English
PY - 2010
SN - ["2041-1006", "2041-1014"]
SP - 357-367
ST - Using DGGE profiling to develop a novel culture medium suitable for oral
microbial communities
TI - Using DGGE profiling to develop a novel culture medium suitable for oral
microbial communities
VL - 25
ID - 14002
ER -
TY - JOUR
AB - The objectives of the present study were to establish in a long-term
investigation the safety as well as the clinical and microbiological efficacy of
scaling and rootplaning combined with local application of 2% minocycline
hydrochloride-gel versus placebo-gel in patients with moderate to severe chronic
adult periodontitis. This was an 18 months, randomized, double-blind, parallel,
comparative study, in which 20 healthy patients with moderate to severe chronic
periodontitis participated. At baseline, all patients received professional oral
hygiene-instruction and supra- and subgingival scaling and root planing. The
minocycline-gel was applied subgingivally baseline, 2 weeks, 1, 3, 6, 9 and 12
months. Microbiological evaluation was carried out using DMDx to identify the
following bacteria: Porphyromonas gingivalis, Prevotella intermedia, Actinobacillus
actinomycetemcomitans, Campylobacter rectus, Fusobacterium nucleatum and Treponema
denticola. In addition standard microbiological techniques were used for the
detection of P. gingivalis, P. intermedia, P. micros, A. actinomycetemcomitans, C.
rectus, F. nucleatum, C. albicans and Enterobacteriaceae. Results showed a
statistically significant improvement for all clinical parameters irrespective of
the treatment modality. No differences were observed between test and control with
regard to probing depth and attachment level. The DMDx data showed a significant
reduction in both the numbers and the prevalence over the 15 months period, but no
significant difference between groups. Culture data showed that at baseline two-
third were positive for P. gingivalis and P. intermedia. Analysis over the 18 month
period showed no significant difference between the two treatment modalities. C.
albicans and Enterobacteriaceae were detected only in small proportions at each
time interval in a limited number of patients. No adverse reactions were observed
during the trial period. The present patient group responded favourably to scaling
and rootplaning, but did not benefit from an effect of local of minocycline.
Subgingival debridement in combination with oral hygiene instruction by itself has
been shown to be effective. It remains to be studied whether local application of
minocycline can be effective as an adjunct to mechanical therapy in sites that
respond poorly to conventional treatment.
AN - rayyan-563561060
AU - Timmerman, M. F.
AU - van der Weijden, G. A.
AU - van Steenbergen, T. J.
AU - Mantel, M. S.
AU - de Graaff, J.
AU - van der Velden, U.
IS - 8
bacterial DNA
minocycline
adult
article
bacterial count
bacterium
clinical trial
controlled study
female
human
male
microbiology
middle aged
nonparametric test
periodontics
periodontitis
tooth plaque
LA - English
PY - 1996
SN - 0303-6979
SP - 707-716
ST - Evaluation of the long-term efficacy and safety of locally-applied
minocycline in adult periodontitis patients
TI - Evaluation of the long-term efficacy and safety of locally-applied
minocycline in adult periodontitis patients
VL - 23
ID - 14434
ER -
TY - JOUR
AN - rayyan-563561681
AU - Tito, M. S.
AU - Hanco, J. A.
IS - 2
PY - 2021
ST - Antibacterial activity of an experimental eucalyptus globulus labill gel
against porphyromonas gingivalis
T2 - Revista Cubana de Investigaciones Biomedicas
TI - Antibacterial activity of an experimental eucalyptus globulus labill gel
against porphyromonas gingivalis
85113794287&partnerID=40&md5=9047eda3676c448420b42e112159ee22
VL - 40
ID - 15055
ER -
TY - JOUR
AB - This study reports on the development of novel biodegradable microspheres
prepared by oil-in-water-oil (O/W/O) double emulsion technique using the blends of
poly (D, L-lactide-co-glycolide) (PLGA) and polycaprolactone (PCL) in different
ratios for the controlled delivery of metronidazole (MTZ). Metronidazole
encapsulation of up to 40% was achieved within the polymeric microspheres. Blend
placebo microspheres, drug-loaded microspheres were analyzed by Fourier transform
infrared spectroscopy (FT-IR), which indicated no interaction between drug and
polymers. Differential scanning calorimetry (DSC) on drug-loaded microspheres
confirmed the polymorphism of MTZ and indicated a molecular level dispersion of MTZ
in the microspheres. Scanning electron microscopy (SEM) confirmed the spherical
nature and smooth surfaces of the microspheres produced. Mean particle size of the
microspheres as measured by dynamic laser light scattering method ranged between
100 and 200 μm. In vitro release studies performed in 7.4 pH media indicated the
release of MTZ from 7 to 11 days, depending upon the blend ratio of the matrix. Up
to 11 days, MTZ concentrations in the gingival crevicular fluid were higher than
the minimum inhibitory concentration of MTZ against most of the periodontal
pathogens. Statistical analyses of the release data were performed using the
analysis of variance (ANOVA) method.
AN - rayyan-563560622
AU - Tiwari, G.
IS - 2
KW - metronidazole
microsphere
polycaprolactone
polyglactin
article
controlled study
drug half life
drug stability
emulsion
encapsulation
gel
in vitro study
light scattering
particle size
periodontal disease
pH
shelf life
LA - English
PY - 2010
SN - 0975-6299
ST - Biodegradable microspheres for controlled delivery of metronidazole in the
treatment of periodontal diseases: Formulation consideration
TI - Biodegradable microspheres for controlled delivery of metronidazole in the
treatment of periodontal diseases: Formulation consideration
VL - 1
ID - 13996
ER -
TY - JOUR
AB - The present study aims at the development and evaluation of dental gel
containing metronidazole non-biodegradable polymers for targeted delivery of drug
and thus prolonging the action. Hot Method was used for the preparation of gel.
Natural polymers like, Guar gum, Sodium alginate, Chitosan, Xanthan gum, Gellan gum
were used in the formulations of gel. Prepared gels were evaluated for pH,
rheological study, spreadability study, gelation, and gel melting study. At last
Field Emission Scanning Electron Microscopy FESEM, Differential Scanning
Calorimetry (DSC), Thermo Gravimetric Analysis (TGA), Texture Profile Analysis
(TPA) have been done on an optimized gel formulation. All gels revealed pH ranged
between 6.16 to 6.47, spreadability between 28.37 to 45.03 g.cm/sec, drug content
between 90.01 to 99.10 % viscosity ranged between 3108.44 cps and 3645.47 cps and
formulations F3 and F10 showed gelation temperature 39±0.12OC and 37±0.13OC
respectively which is similar to the temperature of the body. Surface of the sample
gels showed no drug particles, indicating a homogeneous mixture of polymers of
drugs as well as natural agents. Formulation F10 containing Guar gum showed slower
degradation in all media as compared to gels made of Sodium alginate, Xanthan gum,
Chitosan, Gellan gum. DSC results revealed that the drug has the same state in the
optimized formulation. TGA results showed that the formulation was found to have
high stability in high-temperature settings. TPA results of optimized F10 revealed
the parameters Mucoadhesive strength 92.54 ± 2.65 g, Hardness 25.34 ± 0.01N/mm²,
Compressibility 57.75 ± 0.40N mm, Adhesiveness−4.56 ± 0.26 N mm, Cohesiveness 0.83
± 0.06. Hence, it is concluded that Metronidazole gel with gellan gum showed a
longer degradation time and guar gum showed slower degradation in all over polymers
used in gel formulations.
AN - rayyan-563559792
AU - Tiwari, G.
AU - Singh, G.
AU - Shekhar, R.
AU - Tiwari, R.
DO - 10.52711/0974-360X.2022.00880
IS - 11
SDTQ 600
sonicator
spectrophotometer
alcohol
alginic acid
antiinfective agent
chitosan
curcumin
gel
gellan
gelling agent
glycerol
guar gum
metronidazole
polymer
propylene glycol
xanthan
article
drug formulation
drug release
encapsulation
field emission scanning electron microscopy
gelation
incubation time
kinetics
melting point
mouth cavity
nonhuman
oxidation
periodontal disease
pH
spectrophotometry
thermogravimetry
turbidity
LA - English
PY - 2022
SN - ["0974-360X", "0974-3618"]
SP - 5225-5231
ST - Development and qualitative evaluation of periodontal gel containing an
antibacterial agent for periodontal disease
TI - Development and qualitative evaluation of periodontal gel containing an
antibacterial agent for periodontal disease
VL - 15
ID - 13166
ER -
TY - JOUR
AB - Aim: The aim of this study to develop the controlled delivery of combination
drug(s) to periodontal pocket. Materials and Methods: In the present investigation
mucoadhesive gel formulations were prepared using carboxy methylcellulose (CMC),
methylcellulose (MC), hydroxyethylcellulose (HEC), polyvinylpirrolidone (PVP),
polycarbophil (PC), and poloxamer. Each formulation was characterized in terms of
polarizing light microscopy, gelation, gel melting, hardness, compressibility,
adhesiveness, cohesiveness, syringeability, adhesion to a mucin disk, rheological
studies, drug release, and antibacterial activities. Addition of CMC and PVP to the
gel favored hexagonal phase formation. The gelation temperature was decreased
linearly with an increasing concentration of drug(s), whereas, the melting
temperature increased with the concentration of drug(s). Increasing the
concentrations of each polymeric component significantly increased formulation
hardness, compressibility, adhesiveness, mucoadhesion, and syringeability, yet a
decreased cohesiveness. Increased time of contact between the formulation and mucin
significantly increased the required force of detachment. Drug release from all
formulations was non-diffusion controlled and significantly decreased as the
concentration of the polymer was increased, due to the concomitant increased
viscosity of the formulations and the swelling kinetics of PC, following contact
with the dissolution fluid. Result: Antibacterial studies revealed that a gel with
30% HEC had a growth inhibition zone on agar with all three strains. Conclusion:
Formulations containing HEC exhibited superior physical characteristics for
improved drug delivery to the periodontal pocket and are now the subject of long-
term clinical investigations.
AN - rayyan-563560653
AU - Tiwari, G.
AU - Tiwari, R.
AU - Rai, A. K.
DO - 10.4103/0970-9290.62814
IS - 1
KW - doxycycline
metronidazole
adhesion
article
biomechanics
chemistry
dental procedure
drug combination
drug design
drug effect
Escherichia coli
flow kinetics
gel
hardness
materials testing
periodontal pocket
LA - English
PY - 2010
SN - ["0970-9290", "1998-3603"]
SP - 72-83
ST - Studies on development of controlled delivery of combination drug(s) to
periodontal pocket
T2 - Indian J. Dent. Res.
TI - Studies on development of controlled delivery of combination drug(s) to
periodontal pocket
VL - 21
ID - 14027
ER -
TY - JOUR
AB - Background: The aim of this study was to evaluate if adjunctive, locally
delivered controlled-release doxycycline might improve the outcome of
reinstrumentation of pathologic pockets persisting after initial periodontal
therapy. Methods: Subjects with chronic periodontitis underwent initial treatment
including full-mouth ultrasonic debridement and oral hygiene instructions. At the
3-month reexamination, 32 subjects with remaining pathologic sites were assigned
randomly to one of two retreatment protocols: ultrasonic instrumentation alone
(control) or ultrasonic instrumentation plus application of an 8.8% doxycycline gel
(test). Clinical examinations of plaque, probing depth (PD), relative attachment
level (RAL), and bleeding on probing were performed before retreatment (baseline)
and after 3 and 9 months. Primary efficacy variables were the percentage of closed
pockets, i.e., PD ≤4 mm, and changes in PD and RAL. Results: Baseline examination
revealed no significant difference in mean PD between treatment groups. The mean PD
reduction at 3 months was 0.9 mm (95% confidence interval [CI]: 0.6 to 1.2) in the
control group and 1.0 mm (95% CI: 0.7 to 1.3) in the test group (P>0.05). At 9
months, both treatment groups showed a mean PD reduction of 1.1 mm. The mean RAL
gain was 0.6 mm at 3 months and ∼0.8 at 9 months for both groups. The probability
of pocket closure was not improved by the adjunctive antibiotic therapy. Only
factors at the tooth site level (plaque presence, furcation involvement, and
presence of an intrabony defect) were identified by multilevel analysis as
significant for the treatment outcome. Conclusion: Locally delivered doxycycline
failed to improve the healing outcome of reinstrumentation of periodontal pockets
showing a poor initial response to pocket/root debridement.
AN - rayyan-563560717
AU - Tomasi, C.
AU - Koutouzis, T.
DO - 10.1902/jop.2008.070383
IS - 3
doxycycline
adult
aged
article
chronic disease
clinical trial
controlled study
female
human
devices
male
middle aged
nonparametric test
periodontics
periodontitis
regression analysis
retreatment
tooth plaque
treatment outcome
ultrasound therapy
LA - English
PY - 2008
SN - 0022-3492
SP - 431-439
ST - Locally delivered doxycycline as an adjunct to mechanical debridement at
retreatment of periodontal pockets
TI - Locally delivered doxycycline as an adjunct to mechanical debridement at
retreatment of periodontal pockets
VL - 79
ID - 14091
ER -
TY - JOUR
AB - Objective: The outcome of non-surgical periodontal therapy is known to be
inferior in smokers compared to non-smokers. In the present study, the question was
asked whether such a difference in healing response may be less evident following
adjunctive use of locally delivered controlled-release doxycycline. Methods: One
hundred and three patients (42 smokers, 61 non-smokers), each having at least eight
periodontal sites with PPD (probing pocket depth) ≥ 5 mm, were following
stratification for smoking randomly assigned to two different treatment protocols;
non-surgical scaling/root planing (Control) or ultrasonic
instrumentation+application of a 8.5% w/w doxycycline gel (Atridox™) (Test).
Instructions in oral hygiene were given to all patients. Clinical examinations of
plaque, PPD, clinical attachment level (CAL) and bleeding following pocket probing
were performed at baseline and after 3 months. Primary efficacy endpoints were
changes in PPD and CAL. Patient mean values were calculated as basis for
statistical analysis (multiple regression analyses). Results: The baseline
examination revealed no significant difference in mean PPD between treatment groups
or between smokers and non-smokers (mean PPD 5.7-5.9 mm). The mean PPD reduction in
the control group at 3-month was 1.1 mm (SD = 0.45) for smokers and 1.5 mm (0.67)
for non-smokers. In the test group the PPD reduction was 1.4 mm (0.60) and 1.6 mm
(0.45) for smokers and non-smokers, respectively. The mean CAL gain for smokers and
non-smokers amounted to 0.5 mm (0.56) and 0.8 mm (0.71), respectively, in the
control group, and to 0.8 mm (0.72) and 0.9 mm (0.82), respectively, in the test
group. Multiple regression analysis revealed that smoking and initial PPD
negatively influenced the treatment outcome in terms of PPD reduction and CAL gain,
while the use of doxycycline had a significant positive effect. Conclusion: Locally
applied controlled-release doxycycline gel may partly counteract the negative
effect of smoking on periodontal healing following non-surgical therapy. ©
Blackwell Munksgaard, 2004.
AN - rayyan-563560860
AU - Tomasi, C.
DO - 10.1111/j.1600-051X.2004.00524.x
IS - 8
doxycycline
adult
article
bleeding
calculation
clinical protocol
clinical trial
controlled study
drug effect
drug formulation
female
gel
human
devices
male
mouth hygiene
multicenter study
periodontal disease
smoking
surgical technique
treatment outcome
ultrasound
virus culture
wound healing
atridox
LA - English
PY - 2004
SN - 0303-6979
SP - 589-595
ST - Locally delivered doxycycline improves the healing following non-surgical
periodontal therapy in smokers
TI - Locally delivered doxycycline improves the healing following non-surgical
periodontal therapy in smokers
VL - 31
ID - 14234
ER -
TY - JOUR
AB - Background The goal was to evaluate the clinical outcome of non-surgical
retreatment at molar furcation sites by ultrasonic debridement with or without
adjunctive application of locally delivered doxycycline, and to explore factors
affecting the healing results. Methods: This study involves 32 patients with
chronic periodontitis, who received initial pocket/root debridement by ultrasonic
instrumentation, followed by random assignment to retreatment of remaining
pathologic sites at 3 months by ultrasonic instrumentation with or without
adjunctive local application of an 8.8% doxycycline gel. Clinical examinations of
plaque, probing depth (PD), relative attachment level, furcation involvement, and
bleeding after furcation probing were performed initially, before retreatment at 3
months (baseline), and 3 and 9 months after retreatment. The primary efficacy
variable was reduction in the degree of furcation involvement. A multilevel
logistic model was used to evaluate the impact of patient and tooth site related
factors on the main outcome variable. Results: The retreatment including locally
delivered doxycycline resulted in closure of 50% of degree I furcation sites,
compared to 29% for sites treated with mechanical debridement only (P >0.05). Of
the degree II furcation sites, 17% in the test and 11% in the control group were
reduced in depth (P >0.05). The logistic multilevel model with ''furcation
improvement'' as the dichotomous outcome variable revealed that local application
of doxycycline had no statistically significant effect. The odds ratio for
''furcation improvement'' was 0.80 (95% confidence interval [CI], 0.65 to 0.99) for
1-mm increase of initial vertical PD, 0.36 (95% CI, 0.17 to 0.80) for initial
furcation involvement degree II compared to degree I, and 0.24 (95% CI, 0.08 to
0.72) for smokers compared to non-smokers. Conclusion: Improvement inmolar
furcation involvement after non-surgical periodontal therapy was not enhanced by
adjunctive locally applied doxycycline and negatively affected by increased
vertical PDand tobacco smoking.
AN - rayyan-563560603
AU - Tomasi, C.
DO - 10.1902/jop.2010.100308
IS - 2
KW - doxycycline
adult
aged
article
clinical trial
controlled study
female
follow up
gel
human
devices
male
methodology
middle aged
molar tooth
pathology
periodontal disease
periodontal pocket
retreatment
smoking
statistical model
tooth root
treatment outcome
ultrasound therapy
LA - English
PY - 2011
SN - 0022-3492
SP - 210-218
ST - Locally delivered doxycycline as an adjunct to mechanical debridement at
retreatment of periodontal pockets: Outcome at furcation sites
TI - Locally delivered doxycycline as an adjunct to mechanical debridement at
retreatment of periodontal pockets: Outcome at furcation sites
VL - 82
ID - 13977
ER -
TY - JOUR
AB - According to the European Pharmacopoeia, Tormentillae rhizoma is the dried
rhizome of tormentil (Potentilla erecta (L.)Raeusch, Rosaceae), freed from the
roots. Tormentillae rhizoma is a traditional herbal medicinal product for
symptomatictreatment of unspecified diarrhoea, mild inflammation of the oral and
pharyngeal mucosa [1]. Dental plaque is a highlydiverse biofilm, with an important
function in maintenance of oral and systemic health. In some conditions the
biofilmbecomes a cause of oral diseases (e.g. periodontal disease) [2]. Current
methods of dental plaque control involve the use ofchemical agents against biofilm
pathogens. This is not sufficiently effective [3]. Prevention and control of dental
plaquemight be achieved by using hydrogels containing compounds that hinder
glucosyltransferase activity and extracellularpolysaccharides synthesis. In this
study, we formulated and performed quality evaluation of new hydrogel
formulationscontaining dry extract of tormentil. Components of dry extract were
identified and tracked by LC-TOF-MS method. Thedominant compounds of tormentil
rhizomes are ellagitannins (agrimoniin) and oligomeric proanthocyanidins.
Duringpreliminary studies using different types of polymers, it was shown that
carmellose natrium-based hydrogel did notinteract with tormentil extract and was
provided optimal physico-chemical and rheological properties. Designed
hydrogelscontaining 5 or 10 mg/g of the dry extract possessed significant
mucoadhesive properties evaluated by TA.XT. Plus TextureAnalyzer and three
different models of adhesive layers (porcine buccal mucosa, mucin and gelatine)
[4]. Theirmucoadhesive properties were determined to be better than commercially
available product used as a control. Hydrogels atconcentrations 5 and 10 mg/g,
exhibited no anti-microbial activity, but strongly inhibited extracellular
polysaccharides andartificial biofilm formation. Based on viscosity and thixotropy
measurements using a programmable viscometer with cone-plate device [5]., it can be
concluded that hydrogels were characterized by desirable thixotropic properties
both at 25C and37C. This study reveals that designed hydrogels seem to be promising
vehicles which can be used for drug delivery inperiodontal disease.
AN - rayyan-563560326
AU - Tomczyk, M.
AU - Sosnowska, K.
AU - Wiater, A.
AU - Strawa, J.
AU - Pleszczynska, M.
AU - Polak, P.
AU - Grochowski, D. M.
AU - Winnicka, K.
DO - 10.1055/s-0036-1597018
KW - adhesive agent
ellagitannin
endogenous compound
gelatin
glucosyltransferase
hydrogel
mucin
polysaccharide
proanthocyanidin
unclassified drug
animal experiment
animal model
biofilm
buccal mucosa
conference abstract
controlled study
drug formulation
nonhuman
oligomerization
periodontal disease
pig
Potentilla
rhizome
synthesis
thixotropy
time of flight mass spectrometry
tooth plaque
viscometer
viscosity
LA - English
PY - 2016
SN - 1439-0221
ST - Formulation and evaluation of hydrogel containing dry extract of Tormentillae
rhizoma designed for periodontal disease
T2 - Planta Med.
TI - Formulation and evaluation of hydrogel containing dry extract of Tormentillae
rhizoma designed for periodontal disease
VL - 82
ID - 13700
ER -
TY - JOUR
AB - Objectives To evaluate the efficacy of a slow release doxycycline gel (SRD)
adjunctively administered to non-surgical therapy in subjects with recurrent or
persistent periodontitis but acceptable oral hygiene during supportive periodontal
care. Material & methods In this single blind, parallel group, multicentre study,
202 of 203 recruited periodontal maintenance subjects with recurrent or persistent
periodontitis were randomly assigned to subgingival ultrasonic/sonic
instrumentation (USI) with (test) or without (control) subsequent administration of
SRD in all residual periodontal pockets ≥4 mm. Intergroup differences in probing
depth, BOP reductions, treatment time, probing attachment levels were evaluated at
3, 6 and 12 months. The primary outcome was the inter-group difference in absolute
change of probing pocket depth (PPD) 3, 6 and 12 months after intervention. Results
At baseline, the two groups were comparable. At 3 months, the test group showed a
significantly higher decrease in mean probing depth than the control group at 3
months (mean difference = 0.11 mm, 95% CI 0.03-0.19 mm, p = 0.003). Administration
of SRD resulted in significantly greater odds of transition of bleeding pockets ≥5
mm to a category of non bleeding sites with PPD≥4 mm at 3 and 6 months (O.R. = 1.4,
95% CI 1.2-1.8 at 3 months). At 6 months, SRD benefit was observed only in the
deeper pockets. 7.5% of subjects (no significant difference between test and
control) showed disease progression (attachment loss a 2 mm) and were exited from
the study. No difference in the incidence of adverse events was observed between
groups. Conclusion The trial results show that topically administered SRD may
provide short-term benefit in controlling inflammation and deep pockets in treated
periodontal patients participating in a secondary prevention programme and able to
maintain a satisfactory level of oral hygiene. © 2012 John Wiley & curren; Sons
A/S.
AN - rayyan-563560551
AU - Tonetti, M. S.
AU - Lang, N. P.
AU - Cortellini, P.
AU - Suvan, J. E.
AU - Eickholz, P.
AU - Fourmousis, I.
AU - Topoll, H.
AU - Vangsted, T.
AU - Wallkamm, B.
DO - 10.1111/j.1600-051X.2012.01864.x
IS - 5
doxycycline
adult
article
comparative study
controlled study
disease course
drug effect
female
follow up
gingiva bleeding
human
male
methodology
middle aged
mouth hygiene
multicenter study
periodontal disease
periodontal pocket
periodontics
periodontitis
recurrent disease
safety
secondary prevention
treatment outcome
ultrasound therapy
wound healing
LA - English
PY - 2012
SN - ["0303-6979", "1600-051X"]
SP - 475-482
ST - Effects of a single topical doxycycline administration adjunctive to
mechanical debridement in patients with persistent/recurrent periodontitis but
acceptable oral hygiene during supportive periodontal therapy
TI - Effects of a single topical doxycycline administration adjunctive to
mechanical debridement in patients with persistent/recurrent periodontitis but
acceptable oral hygiene during supportive periodontal therapy
VL - 39
ID - 13925
ER -
TY - JOUR
AB - Curdlan, a bacteria-derived polysaccharide resource, possesses substantial
potential for periodontal anti-microbial delivery. Here, the facile engineering of
a functionalized curdlan/polydopamine (PDA) composite hydrogels was reported. The
physiochemical evaluations of composite hydrogels proved their tunable properties
associated with concentration of PDA including pore size, rheological property and
swelling behavior. We have systematically assessed biocompatibility in vitro and
found these hydrogels toxicity-free. Moreover, photo -thermal performance upon near
infrared light (NIR) exposure was conducted and eventually indicated the best
matches for antibacterial application. The acetate chlorhexidine (CHX) was chosen
as a model antimicrobial and the release profiles demonstrated the entrapped CHX
could be triggered and nicely controlled by NIR. The optimized bacteriostatic rate
reached 99.9 %. Overall, we aimed to provide new curdlan-based hydrogels for
antibacterial treatment effect and antimicrobial
AN - rayyan-563562165
AU - Tong, X. Q.
AU - Qi, X. L.
AU - Mao, R. T.
AU - Pan, W. H.
AU - Zhang, M. Y.
AU - Wu, X.
AU - Chen, G.
AU - Shen, J. L.
AU - Deng, H.
AU - Hu, R. D.
DO - 10.1016/j.carbpol.2020.116585
PY - 2020
SN - ["0144-8617", "1879-1344"]
ST - Construction of functional curdlan hydrogels with bio-inspired polydopamine
for synergistic periodontal antibacterial therapeutics
TI - Construction of functional curdlan hydrogels with bio-inspired polydopamine
VL - 245
Y2 - 10 y3 - 1
ID - 15539
ER -
TY - JOUR
AB - Curdlan, a bacteria-derived polysaccharide resource, possesses substantial
potential for periodontal antimicrobial delivery. Here, the facile engineering of a
functionalized curdlan/polydopamine (PDA) composite hydrogels was reported. The
physiochemical evaluations of composite hydrogels proved their tunable properties
associated with concentration of PDA including pore size, rheological property and
swelling behavior. We have systematically assessed biocompatibility in vitro and
found these hydrogels toxicity-free. Moreover, photothermal performance upon near
infrared light (NIR) exposure was conducted and eventually indicated the best
matches for antibacterial application. The acetate chlorhexidine (CHX) was chosen
as a model antimicrobial and the release profiles demonstrated the entrapped CHX
could be triggered and nicely controlled by NIR. The optimized bacteriostatic rate
reached 99.9 %. Overall, we aimed to provide new curdlan-based hydrogels for
periodontal antibacterial treatment by combining photothermal effect and
antimicrobial simultaneously.
AN - rayyan-563560090
AU - Tong, X.
AU - Qi, X.
AU - Mao, R.
AU - Pan, W.
AU - Zhang, M.
AU - Wu, X.
AU - Chen, G.
AU - Shen, J.
AU - Deng, H.
AU - Hu, R.
DO - 10.1016/j.carbpol.2020.116585
beta glucan
biomaterial
chlorhexidine
curdlan
indole derivative
polydopamine
polymer
cell culture
cell survival
chemistry
cytology
drug effect
drug potentiation
drug release
Escherichia coli
flow kinetics
human
hydrogel
infrared radiation
microbial viability
microbiology
periodontitis
photochemistry
porosity
procedures
LA - English
PY - 2020
SN - 1879-1344
SP - 116585
ST - Construction of functional curdlan hydrogels with bio-inspired polydopamine
TI - Construction of functional curdlan hydrogels with bio-inspired polydopamine
VL - 245
ID - 13464
ER -
TY - JOUR
AB - Enoxacin inhibits binding between the B-subunit of vacuolar H+-ATPase (V-
ATPase) and microfilaments, and also between osteoclast formation and bone
resorption in vitro. We hypothesized that a bisphosphonate derivative of enoxacin,
bis-enoxacin (BE), which was previously studied as a bone-directed antibiotic,
might have similar activities. BE shared a number of characteristics with enoxacin:
It blocked binding between the recombinant B-subunit and microfilaments and
inhibited osteoclastogenesis in cell culture with IC50s of about 10 μM in each
case. BE did not alter the relative expression levels of various osteoclast-
specific proteins. Even though tartrate-resistant acid phosphatase 5b was
expressed, proteolytic activation of the latent pro-enzyme was inhibited. However,
unlike enoxacin, BE stimulated caspase-3 activity. BE bound to bone slices and
inhibited bone resorption by osteoclasts on BE-coated bone slices in cell culture.
BE reduced the amount of orthodontic tooth movement achieved in rats after 28 days.
Analysis of these data suggests that BE is a novel anti-resorptive molecule that is
active both in vitro and in vivo and may have clinical uses. Abbreviations: BE,
bis-enoxacin; V-ATPase, vacuolar H+-ATPase; TRAP, tartrate-resistant acid
phosphatase; αMEM D10, minimal essential media, alpha modification with 10% fetal
bovine serum; SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis;
RANKL, receptor activator of nuclear factor kappa B-ligand; NFATc1, nuclear factor
of activated T-cells; ADAM, a disintegrin and metalloprotease domain; OTM,
orthodontic tooth movement. © International & American Associations for Dental
Research.
AN - rayyan-563560468
AU - Toro, E. J.
AU - Zuo, J.
AU - Guiterrez, A.
AU - La Rosa, R. L.
AU - Gawron, A. J.
AU - Bradaschia-Correa, V.
AU - Arana-Chavez, V.
AU - Dolce, C.
AU - Rivera, M. F.
AU - Kesavalu, L.
AU - Bhattacharyya, I.
AU - Neubert, J. K.
AU - Holliday, L. S.
DO - 10.1177/0022034513501876
IS - 10
caspase 3
enoxacin
nucleic acid synthesis inhibitor
proton transporting adenosine triphosphate synthase
actin filament
alveolar bone loss
animal
anti-resorptive
apoptosis
article
bovine
cell culture
drug antagonism
drug effect
male
metabolism
microfilament
osteoclast
osteoclastogenesis
periodontal disease
protein binding
rat
Sprague Dawley rat
V-ATPase
LA - English
PY - 2013
SN - ["0022-0345", "1544-0591"]
SP - 925-931
ST - Bis-enoxacin inhibits bone resorption and orthodontic tooth movement
T2 - J. Dent. Res.
TI - Bis-enoxacin inhibits bone resorption and orthodontic tooth movement
VL - 92
ID - 13842
ER -
TY - JOUR
AB - Objective To provide an in-depth catalog of the salivary proteome and
endogenous peptidome of healthy dogs, evaluate proteins and peptides with
antimicrobial properties, and compare the most common salivary proteins and
peptides between different breed phylogeny groups. Methods 36 healthy dogs without
evidence of periodontal disease representing four breed phylogeny groups, based
upon single nucleotide polymorphism haplotypes (ancient, herding/sight-hound, and
two miscellaneous groups). Saliva collected from dogs was pooled by phylogeny group
and analyzed using nanoscale liquid chromatography-tandem mass spectrometry.
Resulting tandem mass spectra were compared to databases for identification of
endogenous peptides and inferred proteins. Results 2,491 proteins and endogenous
peptides were found in the saliva of healthy dogs with no periodontal disease. All
dog phylogeny groups' saliva was rich in proteins and peptides with antimicrobial
functions. The ancient breeds group was distinct in that it contained unique
proteins and was missing many proteins and peptides present in the other groups.
Conclusions and clinical relevance Using a sophisticated nanoscale liquid
chromatography-tandem mass spectrometry, we were able to identify 10-fold more
salivary proteins than previously reported in dogs. Seven of the top 10 most
abundant proteins or peptides serve immune functions and many more with various
antimicrobial mechanisms were found. This is the most comprehensive analysis of
healthy canine saliva to date, and will provide the groundwork forfuture studies
analyzing salivary proteins and endogenous peptides in diseasestates.
AN - rayyan-563562576
AU - Torres, S. M. F.
AU - Furrow, E.
AU - Souza, C. P.
AU - Granick, J. L.
AU - de Jong, E. P.
AU - Griffin, T. J.
AU - Wang, X.
DO - 10.1371/journal.pone.0191307
IS - 1
PY - 2018
SN - 1932-6203
ST - Salivary proteomics of healthy dogs: An in depth catalog
T2 - PLOS ONE
TI - Salivary proteomics of healthy dogs: An in depth catalog
VL - 13
Y2 - 1 y3 - 12
ID - 15950
ER -
TY - JOUR
AB - Purpose: Chlorhexidine (CHX) is an antimicrobial agent used in the prevention
of tooth decay, periodontal disease, and postextraction alveolar osteitis (AO).
Recently, a bioadhesive gel to deliver the active substance, CHX, was introduced.
The intra-alveolar placement of the bioadhesive gel allows a more direct and
prolonged therapeutic effect of CHX, which is useful in the prevention of AO after
extraction of impacted third molars. The intra-alveolar application of the
bioadhesive CHX gel in patients with bleeding disorders may increase the risk of
postoperative bleeding complications. Inversely, bleeding disorders might influence
the efficacy of CHX for AO prevention. The purpose of the present study was to
evaluate the effectiveness of the bioadhesive 0.2% CHX gel in reducing the
incidence of impacted third molar postextraction AO in patients with bleeding
disorders. Materials and Methods: We performed a double-blind, randomized,
parallel-group study of 38 patients with bleeding disorders. The experimental group
(n = 14) was treated with bioadhesive 0.2% CHX gel applied intraoperatively once
after surgical removal of the third molar. The control group (n = 24) was treated
in an identical fashion with placebo gel. Results: We observed a 57.15% reduction
in the incidence of AO in the experimental group. The control group had a 17%
incidence of AO and the experimental group had a 7% incidence of AO (P = .402).
Bleeding complications occurred in 21% of the experimental group compared with 29%
of the control group (P = .601). Conclusions: As described in previous studies, the
single intra-alveolar application of the bioadhesive 0.2% CHX gel in an
intraoperative fashion seems to reduce the incidence of AO after removal of
impacted third molars in patients with bleeding disorders. On the basis of the
reported percentage of bleeding complications, the routine use of postoperative
local hemostatic measures is recommended. © 2010 American Association of Oral and
Maxillofacial Surgeons.
AN - rayyan-563560643
AU - Basallote-Garcia, M.
AU - Gonzalez-Martin, M.
DO - 10.1016/j.joms.2009.08.022
IS - 6
KW - chlorhexidine
cocodamol
codefferalgan
placebo
unclassified drug
adult
alveolar osteitis
article
bleeding disorder
clinical article
clinical trial
controlled study
dental surgery
drug efficacy
female
hemophilia A
hemophilia B
hemostasis
hepatitis A
human
incidence
intraoperative period
liver cirrhosis
male
molar tooth
oral bleeding
osteitis
postoperative care
postoperative pain
tooth disease
tooth extraction
treatment outcome
von Willebrand disease
LA - English
PY - 2010
SN - 0278-2391
SP - 1322-1326
ST - Randomized, Double-Blind Study of Effectiveness of Intra-Alveolar Application
of Chlorhexidine Gel in Reducing Incidence of Alveolar Osteitis and Bleeding
Complications in Mandibular Third Molar Surgery in Patients With Bleeding Disorders
T2 - J. Oral Maxillofac. Surg.
TI - Randomized, Double-Blind Study of Effectiveness of Intra-Alveolar Application
of Chlorhexidine Gel in Reducing Incidence of Alveolar Osteitis and Bleeding
Complications in Mandibular Third Molar Surgery in Patients With Bleeding Disorders
VL - 68
ID - 14017
ER -
TY - JOUR
AB - Gingivitis is a common and mild form of periodontal disease and can be
described as a limited inflammation of the gingiva. This study aims to develop and
characterize rapid releasing mucoadhesive fibers containing ornidazole with
electrospinning process for the treatment of gingivitis. Polyvinylpyrrolidone (PVP)
was chosen as a polymer and used at different concentrations of 10%, 12.5%, and
15%. Scanning electron microscopy images showed that fiber diameters increased with
increasing polymer concentrations. Tensile strength and elongation at break values
of fibers increased with increasing PVP amount, whereas the loading of ornidazole
into the fibers decreased these parameters. The contact angle values of all fibers
were found to be 0 degrees due to the hydrophilic nature of PVP. Ornidazole was
released within 5min and diffused from all of the fibers faster than that of gel
and solution formulations. Electrospun ornidazole fibers were found efficient
against Porphyromonas gingivalis in antimicrobial activity studies. The results
demonstrated that ornidazole loaded fibers could be a potential drug delivery
system for the treatment of gingivitis.
AN - rayyan-563562590
AU - Tort, S.
AU - Yildiz, A.
AU - Tugcu-Demiroz, F.
AU - Akca, G.
AU - Kuzukiran, O.
AU - Acarturk, F.
DO - 10.1080/10837450.2019.1615088
IS - 7
PY - 2019
SN - ["1083-7450", "1097-9867"]
SP - 864-873
ST - Development and characterization of rapid dissolving ornidazole loaded PVP
electrospun fibers
T2 - PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
TI - Development and characterization of rapid dissolving ornidazole loaded PVP
electrospun fibers
VL - 24
Y2 - 8 y3 - 9
ID - 15964
ER -
TY - JOUR
AB - Gingivitis is a common and mild form of periodontal disease and can be
described as a limited inflammation of the gingiva. This study aims to develop and
characterize rapid releasing mucoadhesive fibers containing ornidazole with
electrospinning process for the treatment of gingivitis. Polyvinylpyrrolidone (PVP)
was chosen as a polymer and used at different concentrations of 10%, 12.5%, and
15%. Scanning electron microscopy images showed that fiber diameters increased with
increasing polymer concentrations. Tensile strength and elongation at break values
of fibers increased with increasing PVP amount, whereas the loading of ornidazole
into the fibers decreased these parameters. The contact angle values of all fibers
were found to be 0° due to the hydrophilic nature of PVP. Ornidazole was released
within 5 min and diffused from all of the fibers faster than that of gel and
solution formulations. Electrospun ornidazole fibers were found efficient against
Porphyromonas gingivalis in antimicrobial activity studies. The results
demonstrated that ornidazole loaded fibers could be a potential drug delivery
system for the treatment of gingivitis.
AN - rayyan-563560181
AU - Tort, S.
AU - Yıldız, A.
AU - Tuğcu-Demiröz, F.
AU - Akca, G.
AU - Kuzukıran, Ö
AU - Acartürk, F.
DO - 10.1080/10837450.2019.1615088
IS - 7
KW - nanofiber
ornidazole
povidone
article
chemical structure
conductance
contact angle
controlled study
drug formulation
electrospinning
gingivitis
hydrophilicity
molecular weight
mucoadhesion
priority journal
surface property
tensile strength
viscosity
wettability
LA - English
PY - 2019
SN - ["1097-9867", "1083-7450"]
SP - 864-873
ST - Development and characterization of rapid dissolving ornidazole loaded PVP
electrospun fibers
TI - Development and characterization of rapid dissolving ornidazole loaded PVP
electrospun fibers
VL - 24
ID - 13555
ER -
TY - JOUR
AB - INTRODUCTION: Topical metronidazole benzoate preparations, applied directly
into the space between the teeth and, periodontal tissue, are the treatment of
choice for periodontal pockets. Oleogels and hydrogels, as the biomucoadhesive
bases for the manufacturing of these preparations, were developed in our previous
trials. The aim of our latest research was to develop a preparation that would
solve the problem of inhibiting the metronidazole-resistant anaerobic strains,
isolated from the periodontal pockets. METHODS: Metronidazole-resistant strains
were isolated from the periodontal pocket swabs, using the established
susceptibility testing. Further testing of the antimicrobial activity of the
prepared formulations was performed by the membrane-free diffusion method in agar
gel. Oleogels and hydrogels were tested with: tetracycline (2.5%), metronidazole
(25%), and metronidazole benzoate (40%), as well as with oleogels and hydrogels
containing the combination of 2.5% tetracycline and 40% metronidazole benzoate.
RESULTS: Satisfying results were achieved with the preparation containing 2.5%
tetracycline along with metronidazole benzoate. The main fact revealed by this
study was that there was no synergism in tetracycline and metronidazole benzoate
activities, if the strain was susceptible to both active substances. CONCLUSION:
The best results in the inhibition of the growth of metronidazole-resistant
anaerobic strains were obtained by 2.5% tetracycline and metronidazole benzoate
preparations in oleogel base.
AN - rayyan-563560842
AU - Toskić-Radojicić, M.
AU - Nonković, Z.
AU - Loncar, I.
AU - Varjacić, M.
DO - 10.2298/VSP0506453T
IS - 6
metronidazole
oleogels
organic compound
article
drug effect
gel
human
hydrogel
Lactobacillus
microbiology
periodontitis
pharmaceutics
LA - unknown
PY - 2005
SN - 0042-8450
SP - 453-459
ST - Assessment of feasibility of formulation of a preparation for growth
inhibition of metronidazole-resistant strains isolated from periodontal pockets
T2 - Vojnosanit Pregl
TI - Assessment of feasibility of formulation of a preparation for growth
inhibition of metronidazole-resistant strains isolated from periodontal pockets
VL - 62
ID - 14216
ER -
TY - JOUR
AB - INTRODUCTION: Metronidazole is the drug of choice in the treatment of
periodontal pockets up to 5 mm in depth. It is topically applied--directly into the
periodontal pockets. There are no registred trademark preparations for this purpose
in the market of Serbia and Montenegro. The aim of our latest research was to test
the efficacy of newly formulated preparation containing 25% metronidazole suspended
in a lipogel in vitro--in anaerobic cultures isolated from the periodontal pockets,
and in vivo--by the direct application into periodontal pockets. METHODS:
Preparation efficacy was tested in a randomized controlled study involving 25
patients, and was confirmed by the membrane-free agar diffusion method on the
anaerobic strains isolated from the periodontal pockets. The duration of the
testing was 30 days. The preparation was applied twice--immediately after the
taking of the first swab, and on day 15, when the control swab was taken for the
assessment of the effects of the applied preparation. RESULTS: Seven anaerobic
strains were isolated and tested, and each was confirmed as highly susceptible to
metronidazole. Anaerobic strains were not isolated in any of the pockets treated
with metronidazole-containing lipogel. The strains isolated in the control pockets
were the same as were those at the beginning of the study. CONCLUSION:
Metronidazole, in a lipogel-type base applied in the concentration of 25%, provided
an efficient treatment of anaerobic infection in the periodontal pockets.
AN - rayyan-563560838
AU - Nonković, Z.
AU - Loncar, I.
AU - Varjacić, M.
DO - 10.2298/VSP0508565T
IS - 7
metronidazole
adhesion
anaerobic bacterium
article
clinical trial
controlled study
drug effect
gel
human
in vitro study
microbiology
periodontitis
LA - English
PY - 2005
SN - 0042-8450
SP - 565-568
ST - Effects of topical application of metronidazole-containing mucoadhesive
lipogel in periodontal pockets
T2 - Vojnosanit Pregl
TI - Effects of topical application of metronidazole-containing mucoadhesive
lipogel in periodontal pockets
VL - 62
ID - 14212
ER -
TY - JOUR
AB - INTRODUCTION: Topical metronidazole benzoate preparations, applied directly
into the space between the teeth and, periodontal tissue, are the treatment of
choice for periodontal pockets. Oleogels and hydrogels, as the biomucoadhesive
bases for the manufacturing of these preparations, were developed in our previous
trials. The aim of our latest research was to develop a preparation that would
solve the problem of inhibiting the metronidazole-resistant anaerobic strains,
isolated from the periodontal pockets. METHODS: Metronidazole-resistant strains
were isolated from the periodontal pocket swabs, using the established
susceptibility testing. Further testing of the antimicrobial activity of the
prepared formulations was performed by the membrane-free diffusion method in agar
gel. Oleogels and hydrogels were tested with: tetracycline (2.5%), metronidazole
(25%), and metronidazole benzoate (40%), as well as with oleogels and hydrogels
containing the combination of 2.5% tetracycline and 40% metronidazole benzoate.
RESULTS: Satisfying results were achieved with the preparation containing 2.5%
tetracycline along with metronidazole benzoate. The main fact revealed by this
study was that there was no synergism in tetracycline and metronidazole benzoate
activities, if the strain was susceptible to both active substances. CONCLUSION:
The best results in the inhibition of the growth of metronidazole-resistant
anaerobic strains were obtained by 2.5% tetracycline and metronidazole benzoate
preparations in oleogel base.
AN - rayyan-563561451
AU - Nonković, Z.
AU - Loncar, I.
AU - Varjacić, M.
DO - 10.2298/vsp0506453t
IS - 6
J2 - Vojnosanit Pregl
Drug Resistance, Microbial
Gels
Humans
Hydrogels
Lactobacillus/*drug effects/growth & development/isolation & purification
Metronidazole/*pharmacology
Organic Chemicals
Periodontal Pocket/*microbiology
Technology, Pharmaceutical
Tetracyclines/pharmacology
LA - srp
N1 - Vojnomedicinska akademija, Institut za farmaciju, Beograd, Srbija i Crna
Gora.
PY - 2005
SN - 0042-8450 (Print)
SP - 453-9
ST - [Assessment of feasibility of formulation of a preparation for growth
inhibition of metronidazole-resistant strains isolated from periodontal pockets]
T2 - Vojnosanitetski pregled
TI - [Assessment of feasibility of formulation of a preparation for growth
inhibition of metronidazole-resistant strains isolated from periodontal pockets]
VL - 62
Y2 - 6
ID - 14825
ER -
TY - JOUR
AN - rayyan-563561648
AU - Totu, E. E.
AU - Mănuc, D.
AU - Totu, T.
AU - Buga, R. M.
AU - Erci, F.
AU - Cristea, C.
AU - Isildak, I.
DO - 10.3390/membranes12030303
IS - 3
PY - 2022
T2 - Membranes
85126544883&doi=10.3390%2fmembranes12030303&partnerID=40&md5=321141fe1b732d01bcd380
a02219dd29
VL - 12
ID - 15022
ER -
TY - JOUR
AB - (1) Background: The standard treatment for periodontal disease, a chronic
inflammatory state caused by the interaction between biofilms generated by
organized oral bacteria and the local host defense response, consists of calculus
and biofilm removal through mechanical debridement, associated with antimicrobial
therapy that could be delivered either systemically or locally. The present study
aimed to determine the effectiveness of a hyaluronic acid membrane matrix as a
carrier for the controlled release of the active compounds of a formulation
proposed as a topical treatment for periodontal disease, and the influence of pH on
the complex system's stability. (2) Methods: The obtained hyaluronic acid (HA)
hydrogel membrane with dispersed melatonin (MEL), metronidazole (MZ), and
tetracycline (T) was completely characterized through FTIR, XRD, thermal analysis,
UV-Vis and fluorescence spectroscopy, fluorescence microscopy, zeta potential and
dielectric analysis. The MTT viability test was applied to check the cytotoxicity
of the obtained membranes, while the microbiological assessment was performed
against strains of Staphylococcus spp. and Streptococcus spp. The
spectrophotometric investigations allowed to follow up the release profile from the
HA matrix for MEL, MZ, and T present in the topical treatment considered. We
studied the behavior of the active compounds against the pH of the generated
environment, and the release profile of the bioactive formulation based on the
specific comportment towards pH variation. The controlled delivery of the bioactive
compounds using HA as a supportive matrix was modeled applying Korsmeyer-Peppas,
Higuchi, first-order kinetic models, and a newly proposed pseudo-first-order
kinetic model. (3) Results: It was observed that MZ and T were released at higher
active concentrations than MEL when the pH was increased from 6.75, specific for
patients with periodontitis, to a pH of 7.10, characterizing the healthy patients.
Additionally, it was shown that for MZ, there is a burst delivery up to 2.40 x 10(-
5) mol/L followed by a release decrease, while for MEL and T a short release
plateau was recorded up to a concentration of 1.80 x 10(-5) mol/L for MEL and 0.90
x 10(-5) mol/L for T, followed by a continuous release; (4) Conclusions: The
results are encouraging for the usage of the HA membrane matrix as releasing
vehicle for the active components of the proposed topical treatment at a
physiological pH.
AN - rayyan-563562535
AU - Totu, E. E.
AU - Manuc, D.
AU - Totu, T.
AU - Buga, R. M.
AU - Erci, F.
AU - Cristea, C.
AU - Isildak, I.
DO - 10.3390/membranes12030303
IS - 3
PY - 2022
SN - 2077-0375
T2 - MEMBRANES
VL - 12
Y2 - 3
ID - 15909
ER -
TY - JOUR
AB - This clinical trial compared the efficacy of doxycycline (DOX) in β-
cyclodextrin (DOX)/βCD) with DOX- alone in gel on thirty-three subjects with
periodontitis. Patients were randomized to group 1 GI; 10% DOX + scaling and root
planning (SRP); group 2 (GII (10% DOX /β-CD + SRP), and group 3 (GIII; SRP). Gels
were applied in GI and GII at baseline (T0) and 30 days later (T1). Periodontal
Probing Depth (PPD), Clinical Attachment Level (CAL), Bleeding on Probing (BOP) and
Visible Plaque Index (VPI) were evaluated at (T0), 30 days (T1) and 60 days after
T0 (T2). Bone density was analyzed after 18 months (T3). GII showed the most
significant reduction of PPD (2.62 mm; p <0.003), and greatest gain in CAL (2.54 mm
p <0.003) at T2. BOP and the VPI had a strong reduction in all groups at T2 (p
<0.05), both decreased by ≥5 times and 2 times, respectively, in all groups at T1.
Bone density increased in all groups in radiographs (T3). The use of DOX
encapsulated in β-CD gel with SRP resulted in significant improvements in clinical
periodontal parameters; such molecular inclusion of doxycycline into β-CD in gel
for local application is relatively simple and useful in dentistry.
AN - rayyan-563560158
AU - Trajano, V. C. D. C.
AU - Brasileiro, C. B.
AU - Henriques, J. A. S.
AU - Cota, L. M.
AU - Lanza, C. R.
AU - Cortés, M. E.
DO - 10.1590/1807-3107bor-2019.vol33.0112
beta cyclodextrin
beta cyclodextrin derivative
doxycycline
adult
controlled study
dental scaling
drug formulation
female
gel
human
male
middle aged
periodontal disease
periodontal index
periodontitis
plaque index
procedures
root planing
treatment outcome
young adult
LA - English
PY - 2020
SN - 1807-3107
SP - e112
ST - Doxycycline encapsulated in β-cyclodextrin for periodontitis: a clinical
trial
T2 - Braz Oral Res
TI - Doxycycline encapsulated in β-cyclodextrin for periodontitis: a clinical
trial
VL - 33
ID - 13532
ER -
TY - JOUR
AB - Objectives: This experiment was performed to evaluate clinically and
histologically the effect of mechanical therapy with or without antiseptic therapy
on peri-implant mucositis lesions in nine cynomolgus monkeys. Material and methods:
Two ITI titanium implants were inserted into each side of the mandibles. After 90
days of plaque control and soft tissue healing, a baseline clinical examination was
completed. Peri-implant lesions were induced by placing silk ligatures and allowing
plaque to accumulate for 6 weeks. The clinical examination was then repeated, and
the monkeys were randomly assigned to three treatment groups: group A, mechanical
cleansing only; group B, mechanical cleansing and local irrigation with 0.12%
chlorhexidine (CHX) and application of 0.2% CHX gel; and group C, control, no
treatment. The implants in treatment groups A and B were treated and maintained
according to the assigned treatment for two additional months. At the end of the
maintenance period, a final clinical examination was performed and the animals were
sacrificed for biopsies. Results: The mean probing depths (PD) values at mucositis
were: 3.5, 3.7, and 3.4 mm, and clinical attachment level (CAL)=3.8, 4.1, and 3.9
mm for treatment groups A, B and C, respectively. The corresponding values after
treatment were: PD=1.7, 2.1, and 2.5 mm, and CAL=2.6, 2.6, and 3.1 mm. ANOVA of
mean changes (Δ) in PD and CAL after treatment showed no statistical difference
between the treatment groups. Comparison of the mean changes in PD and CAL after
treatment yielded statistical differences between the control and treatment groups
P<0.01. According to the t-test, no statistical difference was found between
treatment groups A and B for the PD reduction but there was a significant
difference for the CAL change, P<0.03. Group A had significantly more recession and
less CAL gain than group B. Non-parametric tests yielded no significant differences
in modified plaque index (mPlI) and gingival index (GI) after treatment between
both treatment groups. Frequencies and percent distributions of the mPlI and GI
scores changed considerably for both treatment groups when compared with the
changes in the control group after treatment. With regard to the histological
evaluation, no statistical differences existed between the treatments for any
linear measurement. The proportion of inflammation found in the mucosal tissues of
the control implants was greater than the one found for both treatment groups,
P<0.01. More importantly, both treatment groups showed a similar low proportion of
inflammation after 2 months of treatment. Conclusions: Within the limitations of
this experiment, and considering the supportive plaque control rendered, it can be
concluded that for pockets of 3-4 mm: (1) mechanical therapy alone or combined with
CHX results in the clinical resolution of peri-implant mucositis lesions, (2)
histologically, both treatments result in minimal inflammation compatible with
health, and (3) the mechanical effect alone is sufficient to achieve clinical and
histologic resolution of mucositis lesions. Copyright © Blackwell Munksgaard 2006.
AN - rayyan-563560771
AU - Trejo, P. M.
AU - Bonaventura, G.
AU - Weng, D.
AU - Caffesse, R. G.
AU - Bragger, U.
AU - Lang, N. P.
DO - 10.1111/j.1600-0501.2005.01226.x
IS - 3
chlorhexidine
titanium
animal
article
chemistry
comparative study
gel
gingiva disease
gingivitis
lavage
Macaca
mandible
pathology
periodontal disease
periodontics
periodontitis
randomization
tooth implantation
tooth plaque
LA - English
PY - 2006
SN - ["0905-7161", "1600-0501"]
SP - 294-304
ST - Effect of mechanical and antiseptic therapy on peri-implant mucositis: An
experimental study in monkeys
TI - Effect of mechanical and antiseptic therapy on peri-implant mucositis: An
experimental study in monkeys
VL - 17
ID - 14145
ER -
TY - JOUR
AB - Context: Chemomechanical caries removal is a non-invasive technique that
eliminates infected dentine via a chemical agent. Papain, owing to its proteolytic
nature causes disruption of degraded collagen fibrils that helps easy removal of
the caries and has both bacteriostatic and bactericidal action. Objective: The
objective of the present work was to formulate and evaluate papain-based in situ
gelling system for chemomechanical caries removal, based on the concept of pH-
triggered in situ gelation and evaluate its pharmaceutical and chemomechanical
characteristics. Material and methodology: A 32 full factorial design was employed
to formulate the in situ gels. Carbopol 934 and HPMC K15M were designated as two
independent variables, each utilized at three different levels and the dependent
variables were gelling capacity, viscosity and % cumulative drug permeated (CDP).
The optimized formulation was assessed for ex vivo clinical efficacy by SEM, micro-
tensile bond strength and antibacterial activity. Results: Formulation F3 with %
CDP of 10.13±0.43% and optimum gelling and viscosity characteristics was optimized.
The efficacy of F3 was confirmed by enhanced micro-tensile bond strength of
38.48±4.14 Mpa compared to 29.42±2.33 Mpa of control group and SEM. Conclusion: An
economically viable papain-based in situ gelling system with clinical potential for
caries removal with enhanced bonding ability was successfully developed.
AN - rayyan-563560407
AU - Tripathi, R. S.
AU - Pathak, K.
DO - 10.3109/10837450.2014.920361
IS - 7
KW - carbopol 934
papain
placebo
adhesion
article
bacteriostasis
controlled study
dental caries
dental procedure
dependent variable
drug efficacy
drug formulation
drug screening
drug solubility
ex vivo study
factorial design
gelation
human
human tissue
in vitro study
pH
priority journal
viscosity
LA - English
PY - 2015
SN - ["1097-9867", "1083-7450"]
SP - 801-811
ST - Optimization studies on development and evaluation of papain-based in situ
gelling system for chemomechanical caries removal
TI - Optimization studies on development and evaluation of papain-based in situ
gelling system for chemomechanical caries removal
VL - 20
ID - 13781
ER -
TY - JOUR
AB - Graphene oxide (GO) was proposed as an efficient carrier of antibiotics. The
model drug, amoxicillin (AMOX), was attached to GO using a peptide linker (Leu-Leu-
Gly). GO-AMOX was dispersed in a hydrogel to which the enzyme responsible for
releasing AMOX from GO was also added. The drug molecules were released by
enzymatic hydrolysis of the peptide bond in the linker. As the selected enzyme,
bromelain, a plant enzyme, was used. The antibacterial nature of the carrier was
determined by its ability to inhibit the growth of the Enterococcus faecalis
strain, which is one of the bacterial species responsible for periodontal and root
canal diseases. The prepared carrier contained only biocompatible substances, and
the confirmation of its lack of cytotoxicity was verified based on the mouse
fibrosarcoma cell line WEHI 164. The proposed type of preparation, as a universal
carrier of many different antibiotic molecules, can be considered as a suitable
solution in the treatment of inflammation in dentistry.
AN - rayyan-563561228
AU - Trusek, A.
AU - Kijak, E.
DO - 10.3390/ma14123182
IS - 12
J2 - Materials (Basel)
LA - eng
N1 - Group of Micro, Nano and Bioprocess Engineering, Department of Chemistry,
Wroclaw University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370
Wroclaw, Poland.; Department of Dental Prosthetics, Wroclaw Medical University,
Krakowska 26, 50-425 Wroclaw, Poland.
PY - 2021
SN - 1996-1944 (Print)
ST - Drug Carriers Based on Graphene Oxide and Hydrogel: Opportunities and
Challenges in Infection Control Tested by Amoxicillin Release
T2 - Materials (Basel, Switzerland)
TI - Drug Carriers Based on Graphene Oxide and Hydrogel: Opportunities and
Challenges in Infection Control Tested by Amoxicillin Release
VL - 14
Y2 - 6 y3 - 9
ID - 14602
ER -
TY - JOUR
AB - A leukotoxin from Actinobacillus actinomycetemcomitans was isolated by a
procedure that includes polymyxin B extraction, ion-exchange chromatography, and
gel filtration chromatography. The procedure resulted in the recovery of 48% of the
toxin with a 99-fold increase in specific activity. The isolated toxin has a
molecular mass of 180,000 daltons by gel filtration and 115,000 daltons by sodium
dodecyl sulfate-polyacrylamide gel electrophoresis. It retains all the major
biological characteristics previously documented for crude leukotoxin preparations,
including susceptibility to heat and proteolytic enzymes and neutralization by sera
from patients with juvenile periodontitis. The isolated leukotoxin destroys human
but not rat or guinea pig polymorphonuclear leukocytes and has no apparent effect
on human erythrocytes. The availability of the A. actinomycetemcomitans leukotoxin
should facilitate studies on its chemistry and mode of action as well as its role
in the pathogenesis of human periodontal disease.
AN - rayyan-563561186
AU - Tsai, C. C.
AU - Shenker, B. J.
AU - Dirienzo, J. M.
AU - Malamud, D.
AU - Taichman, N. S.
DO - 10.1128/iai.43.2.700-705.1984
IS - 2
KW - leukotoxin
polymyxin B
blood and hemopoietic system
etiology
gel filtration
human
human cell
mouth
neutrophil
pathogenesis
periodontal disease
LA - English
PY - 1984
SN - 0019-9567
SP - 700-705
ST - Extraction and isolation of a leukotoxin from Actinobacillus
actinomycetemcomitans with polymyxin B
T2 - INFECT. IMMUN.
TI - Extraction and isolation of a leukotoxin from Actinobacillus
actinomycetemcomitans with polymyxin B
VL - 43
ID - 14560
ER -
TY - JOUR
AB - Mesoporous nanoparticles (MSNs) constitute promising carriers for the
adsorption and local control release of biological active agents that promote bone
regeneration. Doping MSNs with cerium ions could contribute to control over
bacterial contamination and enhance the capability of vascularization, eliminating
the chance of bone loss1. The aim of this study was the evaluation of the
antioxidant agent artemisinin2 loading/release profiles, biocompatibility and
hemolytic activity of different Ce-doped MSNs (1, 2.5 and 5%). MCM-41 mesoporous
nanoparticles were synthesized via sol-gel and had either neat siliceous or metal
(Ca and Ce) substituted walls. CRay Diffraction analysis and N2 porosimetey were
used to determine their structural characteristics. Their drug loading and release
profiles were assessed with Liquid Chromatography-Mass Spectrometry (LC-MS) and
their cell viability with the MTT assay on human periodontal ligament cells
(hPDLCs). Their hemolytic activity was evaluated in contact with human red blood
cells at various concentrations (12.5-500mg/ml). A high loading capacity was
recorded for all Ce-doped MSNs (73-85%) that was higher compared to pure silica
(64%). Artemisinin release was verified after sonication for 40 min, without
significant differences among MSNs. At low concentrations MSNs presented no
hemolytic activity, while at high concentrations the lowest hemolytic activity was
recorded for the MSNs with the highest amount of cerium. The 1 and 2.5% Ce-doped
MSNs significantly promoted mitochondrial activity and proliferation of hPDLCs. In
conclusion, cerium can be incorporated in MSNs to improve their performance in
terms of biocompatibility, hemolytic activity and loading of artemisinin.
AN - rayyan-563559873
AU - Tsamesidis, I.
AU - Gkiliopoulos, D.
AU - Reybier, K.
AU - Perio, P.
AU - Triantafyllidis, K.
KW - antioxidant
artemisinin
calcium
cerium
silicon dioxide
biocompatibility
cell proliferation
cell viability
conference abstract
controlled study
diffraction
erythrocyte
hemolysis
human
human cell
human tissue
mitochondrion
MTT assay
sol-gel
substitution reaction
ultrasound
LA - English
PY - 2022
SN - 1937-335X
SP - S421
ST - CERIUM DOPED MESOPOROUS NANOPARTICLES FOR DRUG DELIVERY OF ARTEMISININ
TI - CERIUM DOPED MESOPOROUS NANOPARTICLES FOR DRUG DELIVERY OF ARTEMISININ
VL - 28
ID - 13247
ER -
TY - JOUR
AB - The article presents the results of a pharmacodynamic study of a new gel
containing an extract of Aloe vera and an extract of oak bark under the condition
of destructive inflammatory periodontal diseases. Pharmacodynamics of the new gel
was studied by the following methods: antimicrobial effect – by diffusion method in
agar gel (compared product – Metrogyl denta® gel); reparative effect – on the model
of linear cut wounds (compared product – Calendula ointment); anti-inflammatory
activity – on the model of acute carrageenan-induced inflammation (compared product
– Diclofenac natrium gel 5%). It has been established that the antimicrobial
activity of the new gel against Staphylococcus aureus ATCC 25923, Escherichia coli
ATCC 25922, Bacillus subtilis ATCC 6633, Pseudomonas aeruginosa ATCC 27853, Candida
albicans NCTC 885-653, Escherichia faecalis ATCC 29212, and Staphylococcus mutans
ATCC 35668 is slightly lower in comparison with Metrogyl denta® gel exhibiting a
powerful antimicrobial activity. According to the reparative effect on the model of
linear cut wounds, the new gel exceeded the effectiveness (by 24%, p < 0.001) of
the compared drug based on the medicinal plant material – Calendula ointment. A
significant anti-inflammatory activity of the new gel has been revealed under the
conditions of acute carrageenan inflammation. It exceeded the Diclofenac natrium
gel in the first hours of the experiment, indicating an anti-lipoxygenase activity
of the new gel. The established antimicrobial, reparative and anti-inflammatory
activity of a new gel containing aloe vera and oak bark extracts confirmed its
potential use in the treatment of destructive inflammatory periodontal diseases.
AN - rayyan-563560148
AU - Tsubanova, N. A.
AU - Zhurenko, D. S.
IS - 3
carrageenan
Aloe vera
animal experiment
animal model
article
Bacillus subtilis
Candida albicans
controlled study
Escherichia coli
Escherichia faecalis
inflammation
nonhuman
oak
periodontal disease
pharmacodynamic parameters
Staphylococcus mutans
LA - English
PY - 2020
SN - ["1805-4439", "1210-7816"]
SP - 143-148
ST - A pharmacodynamic study of a new gel containing an extract of aloe vera and
T2 - Farmakodynamická studie nového gelu obsahujícího extrakt z aloe vera a
extrakt z dubové kůry pro potenciální léčbu onemocnění parodontu
TI - A pharmacodynamic study of a new gel containing an extract of aloe vera and
VL - 69
ID - 13522
ER -
TY - JOUR
AB - Introduction: Today in many countries, there is a clear trend to a growing
number of major diseases of the oral cavity, due to the poor state of the
environment, unbalanced diet, and concomitant chronic diseases of the
gastrointestinal tract. Topical problem of modern medicine and pharmacy is
optimization of pharmacotherapy of inflammatory periodontal diseases. The aim of
the study was to establish optimal combination of new gel for the treatment of
periodontal disease. Materials and Methods: The experimental studies were conducted
on white male rats. Research of membrane protective activity was carried out on the
standard model of spontaneous hemolysis of erythrocytes by Jager. The research of
antimicrobial activity was carried out by method of diffusion in agar. Research of
Parodont-protective effect was carried out on the model protamine periodontitis.
Results and Discussions: Extract of Aloe has powerful membrane protective effect in
different doses. The study in vitro showed the high sensitivity of thick oak bark
extract in the form of a gel to the cultures of Staphylococcus aureus, Pseudomonas
aeruginosa, Bacillus subtilis, and Candida albicans that allows to recommend it for
the treatment of inflammatory diseases of the mouth. Conclusions: According to the
results of screening studies, optimal composition of gel that contains Aloe
arborescens and cortex Quercus were selected for the treatment of parodontal
diseases. Parodont-protective activity of gel is confirmed on the protamine
periodontitis model, the ability to decrease the clinical symptoms, namely,
hyperemia, edema and necrotic erosive changes of the gums and mucous membranes of
the mouth.
AN - rayyan-563560303
AU - Tsubanova, N. A.
AU - Zhurenko, D. S.
AU - Khokhlenkova, N. V.
AU - Artiukh, T. O.
IS - 2
animal experiment
article
Bacillus subtilis
bark
erythrocyte
gel
growth inhibition
hemolysis
human
hyperemia
male
membrane stabilization
nonhuman
oak
optimal drug dose
periodontal disease
periodontitis
rat
LA - English
PY - 2017
SN - ["1998-409X", "0973-8398"]
SP - S353-S357
ST - Screening study for finding the optimal combination gel composition for the
treatment of periodontal disease, which contains extracts of aloe vera and oak bark
TI - Screening study for finding the optimal combination gel composition for the
treatment of periodontal disease, which contains extracts of aloe vera and oak bark
VL - 11
ID - 13677
ER -
TY - JOUR
AB - Home bleaching techniques have been applied as a safe and effective bleaching
procedure. Many manufacturers are now marketing home tooth-bleaching products. The
purpose of this study was to compare a new bleaching product, Polanight (PN) with a
widely used home bleaching product, Opalescence (OP). Fifty-eight healthy Japanese
volunteers of both sexes (18 to 47 years of age) were selected. Using a
simultaneous split-mouth protocol, custom-made trays with PN and OP were applied to
the maxillary right anterior teeth and left anterior teeth, respectively. The
shades of the maxillary canine teeth were measured with a portable chromameter
(Shade Eye Ex) at the first examination and at 4 weeks (after 2-week bleaching and
2-week rest). Tooth shade changes were analyzed usingthe Commission Internationale
d'Eclairage (CIE) Lab units. Means of whiteness-blackness difference (ΔL*),
redness-greenness difference (Δa*), and yellowness-blueness difference (Δb*) were
4.00, -1.28 and -7.53 for PN, and 2.54, -0.99, and -5.56 for OP, respectively.
Means ofcolor difference (ΔE*) were 9.23 and 7.78 for PN and OP, respectively.
Treatment with either agent demonstrated significant bleaching effects produced by
the treatment. The new product, PN, showed significant differences in ΔL* (P <
0.05) and Δb* (P < 0.005), but not in theredness-greenness (a*) value when compared
with OP. Bleaching with PN was considered more effective than that with OP in the
young patient group and in the women. © The Society of The Nippon Dental University
2005.
AN - rayyan-563560783
AU - Tsubura, S.
AU - Yamaguchi, R.
DO - 10.1007/s10266-005-0047-8
IS - 1
oxidizing agent
peroxide
urea
carbamide peroxide
adolescent
adult
age
article
clinical trial
color
colorimetry
comparative study
controlled study
dental procedure
drug combination
female
gel
gingivitis
human
devices
Japan
male
methodology
middle aged
pathology
self care
sex difference
tooth
LA - English
PY - 2005
SN - ["1618-1247", "1618-1255"]
SP - 52-55
ST - Clinical evaluation of a new bleaching product "Polanight" in a Japanese
population
T2 - Odontology
TI - Clinical evaluation of a new bleaching product "Polanight" in a Japanese
population
VL - 93
ID - 14157
ER -
TY - JOUR
AB - Periodontal disease is a bacterial infection that destroys the gingiva and
surrounding tissues of the oral cavity. In recent years, studies have shown a
definite association between periodontal disease and other inflammatory conditions
of the body. High-throughput analysis of proteins has become possible with the
development of MS technology. This breakthrough in proteome technology enables
comparative studies of comprehensive protein expression and identification of
protein. In case of periodontal disease, proteome analysis using 2DE, as well as
gel-free methods, has been reported. As a fluid lying in close proximity to
periodontal tissue, the gingival crevicular fluid (GCF) is the principal target in
the search for biomarkers of periodontal disease, because its protein composition
may reflect the disease pathophysiology. Biochemical marker analysis of GCF is
effective for objective diagnosis in the early and advanced stages of periodontal
disease. Increasing numbers of recent reports have provided evidence that the
proteomic approach is a promising tool for the discovery and identification of
biochemical markers of periodontal disease. This search is of continuing interest
in the field of experimental and clinical periodontal disease research. In this
article, we summarize recent comprehensive proteomic studies aimed at discovering
and identifying biomarkers of periodontal disease in GCF. © 2014 WILEY-VCH Verlag
GmbH & Co. KGaA, Weinheim.
AN - rayyan-563560427
AU - Tsuchida, S.
AU - Satoh, M.
AU - Sogawa, K.
AU - Kawashima, Y.
AU - Kado, S.
AU - Ishige, T.
AU - Beppu, M.
AU - Sawai, S.
AU - Nishimura, M.
AU - Kodera, Y.
AU - Matsushita, K.
AU - Nomura, F.
DO - 10.1002/prca.201300122
IS - 3
KW - actin
alpha amylase 1
angiotensinogen
apolipoprotein A1
azurocidin
biological marker
calgranulin A
ropocamptide
clusterin
cofilin
copper zinc superoxide dismutase
cystantin B
dermcidin
gelatinase B
gelsolin
histone
levo plastin
lipocortin 1
neutrophil gelatinase associated lipocalin
profilin
thymidine phosphorylase
ubiquilin 4
unclassified drug
article
bacterial infection
biochemistry
disease association
gingivitis
human
priority journal
protein analysis
protein expression
proteomics
ultrafiltration
LA - English
PY - 2014
SN - ["1862-8354", "1862-8346"]
SP - 232-240
ST - Application of proteomic technologies to discover and identify biomarkers for
periodontal diseases in gingival crevicular fluid: A review
T2 - Proteomics Clin. Appl.
TI - Application of proteomic technologies to discover and identify biomarkers for
periodontal diseases in gingival crevicular fluid: A review
VL - 8
ID - 13801
ER -
TY - JOUR
AB - The protein composition of gingival crevicular fluid (GCF) may reflect the
pathophysiology of periodontal diseases. A standard GCF proteomic pattern of
healthy individuals would serve as a reference to identify biomarkers of
periodontal diseases by proteome analyses. However, protein profiles of GCF
obtained from apparently healthy individuals have not been well explored. As a step
toward detection of proteomic biomarkers for periodontal diseases, we applied both
gel-based and gel-free methods to analyze GCF obtained from healthy subjects as
compared with supragingival saliva. To ensure optimized protein extraction from
GCF, a novel protocol was developed. The proteins in GCF were extracted with high
yield by urea buffer combined with ultrafiltration and the intensity of spots with
supragingival saliva and GCF was compared using agarose two-dimensional
electrophoresis. Eight protein spots were found to be significantly more intense in
GCF. They included superoxide dismutase 1 (SOD1), apolipoprotein A-I (ApoA-I), and
dermcidin (DCD). Moreover, GCF proteins from healthy subjects were broken down into
small peptide fragments and then analyzed directly by LC-MS/MS analysis. A total of
327 proteins including ApoA-I, SOD1, and DCD were identified in GCF. These results
may serve as reference for future proteomic studies searching for GCF biomarkers of
periodontal diseases. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
AN - rayyan-563560540
AU - Tsuchida, S.
AU - Satoh, M.
AU - Umemura, H.
AU - Sogawa, K.
AU - Kawashima, Y.
AU - Kado, S.
AU - Sawai, S.
AU - Nishimura, M.
AU - Kodera, Y.
AU - Matsushita, K.
AU - Nomura, F.
DO - 10.1002/pmic.201100655
IS - 13
KW - agarose
apolipoprotein A1
dermcidin
urea
adult
article
clinical article
controlled study
disease marker
female
gingiva
gingivitis
human
male
periodontal disease
priority journal
protein analysis
proteomics
saliva analysis
ultrafiltration
LA - English
PY - 2012
SN - ["1615-9853", "1615-9861"]
SP - 2190-2202
ST - Proteomic analysis of gingival crevicular fluid for discovery of novel
periodontal disease markers
T2 - Proteomics
TI - Proteomic analysis of gingival crevicular fluid for discovery of novel
periodontal disease markers
VL - 12
ID - 13914
ER -
TY - JOUR
AB - Objective. The purpose of this in vitro study was to investigate
antimicrobial activity of calcium hydroxide (CH) in combination with glycerin,
chlorhexidine gluconate (CHX), cetrimide, or distilled water against Enterococcus
faecalis and Candida albicans. Study design. Standard holes in the cultivated agar
plates were filled with one of the CH preparations and control agents. The zones of
microbial inhibition were measured after incubation period. Results. The CH
preparations with glycerin and CHX demonstrated more antifungal activity than CH
preparations with cetrimide and distilled water. The CH-glycerin preparations had
no effect against E. faecalis, and CH-CHX preparation was the most effective
medication. Conclusion. Antimicrobial activity of CH may change with the type of
the vehicle and against different microorganisms. Enterococcus faecalis was more
resistant than C. albicans to CH preparations. (Oral Surg Oral Med Oral Pathol Oral
Radiol Endod 2009; 108: 297-301)
AN - rayyan-563562556
AU - Turk, B. T.
AU - Sen, B. H.
AU - Ozturk, T.
DO - 10.1016/j.tripleo.2009.03.029
IS - 2
PY - 2009
SN - ["1079-2104", "1528-395X"]
SP - 297-301
ST - In vitro antimicrobial activity of calcium hydroxide mixed with different
vehicles against Enterococcus faecalis and Candida albicans
TI - In vitro antimicrobial activity of calcium hydroxide mixed with different
vehicles against Enterococcus faecalis and Candida albicans
VL - 108
Y2 - 8
ID - 15930
ER -
TY - JOUR
AB - Background: Recent developments suggest that the local delivery of
antimicrobials into periodontal pockets can improve periodontal health.
Azithromycin (AZM) has a wide antimicrobial spectrum of action toward anaerobic
bacteria as well as Gram-negative bacilli. It is effective against periodontal
pathogens such as Aggregatibacter actinomycetemcomitans and Porphyromonas
gingivalis. Therefore, this study was undertaken to investigate the clinical
effectiveness of AZM at 0.5% concentration in an indigenously prepared
bioabsorbable controlled release gel as an adjunct to non-surgical mechanical
therapy in the treatment of chronic periodontitis. Materials and Methods: Thirty
sites in patients with chronic periodontitis and probing depth (PD) 4-6 mm were
categorized randomly into two treatment groups: Scaling and root planing (SRP) plus
0.5% AZM gel (group 1) and SRP only (group 2). Clinical evaluation was undertaken
using the Gingival Index (GI) of Loe and Silness and plaque was assessed using the
Turesky et al. modification of Quigley Hein Index at baseline and 21 days. Pocket
PD and clinical attachment level (CAL) were also measured. Statistical Analysis:
Results were expressed as mean ± standard deviation and percentages and the data
were analyzed using Statistical Package for Social Sciences (SPSS version 16.0,
SPSS, Chicago, IL) software. Result: Both therapies resulted in significant
improvements. Mean reduction in GI from baseline to 21 days was 1.20 ± 0.41 and
0.73 ± 0.45 in group 1 and group 2, respectively. Plaque Index also improved
through the study period in both groups, i.e., 0.86 ± 0.51 in group 1 and 1.6 ±
0.97 in group 2. Mean PD reduced significantly with SRP plus AZM gel application in
group 1, i.e., 2.1 ± 0.91 mm as compared to 1.0 ± 1.06 mm achieved with SRP alone.
A significant gain in mean CAL gain was observed in the test group (1.8 ± 0.63 mm)
as compared to control group (1.0 ± 1.06 mm). Conclusion: Although both treatment
strategies seem to benefit patients, the adjunctive use of 0.5% of AZM showed
significant results.
AN - rayyan-563560590
AU - Tyagi, P.
AU - Vaish, S.
AU - Dodwad, V.
DO - 10.4103/0019-5359.107017
IS - 6
KW - azithromycin
adult
article
clinical evaluation
controlled study
dental procedure
drug efficacy
human
treatment outcome
LA - English
PY - 2011
SN - ["0019-5359", "1998-3654"]
SP - 223-230
ST - Clinical efficacy of subgingivally delivered 0.5% controlled release
azithromycin gel in the management of chronic periodontitis
T2 - Indian J. Med. Sci.
TI - Clinical efficacy of subgingivally delivered 0.5% controlled release
VL - 65
ID - 13964
ER -
TY - COMP
AB - BACKGROUND: Recent developments suggest that the local delivery of
antimicrobials into periodontal pockets can improve periodontal health.
Azithromycin (AZM) has a wide antimicrobial spectrum of action toward anaerobic
bacteria as well as Gram-negative bacilli. It is effective against periodontal
pathogens such as Aggregatibacter actinomycetemcomitans and Porphyromonas
gingivalis. Therefore, this study was undertaken to investigate the clinical
effectiveness of AZM at 0.5% concentration in an indigenously prepared
bioabsorbable controlled release gel as an adjunct to non-surgical mechanical
therapy in the treatment of chronic periodontitis. MATERIALS AND METHODS: Thirty
sites in patients with chronic periodontitis and probing depth (PD) 4-6 mm were
categorized randomly into two treatment groups: Scaling and root planing (SRP) plus
0.5% AZM gel (group 1) and SRP only (group 2). Clinical evaluation was undertaken
using the Gingival Index (GI) of Loe and Silness and plaque was assessed using the
Turesky et al. modification of Quigley Hein Index at baseline and 21 days. Pocket
PD and clinical attachment level (CAL) were also measured. STATISTICAL ANALYSIS:
Results were expressed as mean±standard deviation and percentages and the data were
analyzed using Statistical Package for Social Sciences (SPSS version 16.0, SPSS,
Chicago, IL) software. RESULT: Both therapies resulted in significant improvements.
Mean reduction in GI from baseline to 21 days was 1.20±0.41 and 0.73±0.45 in group
1 and group 2, respectively. Plaque Index also improved through the study period in
both groups, i.e., 0.86±0.51 in group 1 and 1.6±0.97 in group 2. Mean PD reduced
significantly with SRP plus AZM gel application in group 1, i.e., 2.1±0.91 mm as
compared to 1.0±1.06 mm achieved with SRP alone. A significant gain in mean CAL
gain was observed in the test group (1.8±0.63 mm) as compared to control group
(1.0±1.06 mm). CONCLUSION: Although both treatment strategies seem to benefit
patients, the adjunctive use of 0.5% of AZM showed significant results.
AN - rayyan-563561325
AU - Tyagi, P.
AU - Vaish, S.
AU - Dodwad, V.
CY - India
ET - 6
J2 - Indian J Med Sci
KW - Administration, Sublingual
Adult
Anti-Bacterial Agents/administration & dosage
Azithromycin/*administration & dosage
Female
Follow-Up Studies
Humans
Male
Root Planing/*methods
Treatment Outcome
LA - eng
N1 - Department of Periodontology and Implantology,I.T.S. Centre for Dental
Studies and Research, Muradnagar, Ghaziabad, Uttar Pradesh, India.
PY - 2011
SP - 223-30
ST - Clinical efficacy of subgingivally delivered 0.5% controlled release
T2 - Indian journal of medical sciences
TI - Clinical efficacy of subgingivally delivered 0.5% controlled release
VL - 65
Y2 - 6
ID - 14699
ER -
TY - JOUR
AB - Background/Aim: Although adrenergic agonists have been used in dental
treatments and oral surgery for general anesthesia, their cytotoxicity against
human oral malignant and non-malignant cell has not been well- understood. The
present study was undertaken to investigate the cytotoxicity of five adrenergic
agonists against human oral squamous cell carcinoma (OSCC), glioblastoma,
promyelocytic leukemia, and normal oral mesenchymal cells (gingival fibroblast,
pulp cell, periodontal ligament fibroblast) and normal epidermal keratinocytes.
Materials and Methods: Tumor-specificity (TS) was calculated by the ratio between
the mean 50% cytotoxic concentration against normal cells to that of tumor cells.
Internucleosomal DNA fragmentation was detected using agarose gel electrophoresis.
Caspase-3 activity was measured by substrate cleavage. Results: Both cytotoxicity
and tumor-specificity of adrenergic agonists against OSCC cell lines was in the
order of isoprenaline>dexmedetomidine> adrenaline>clonidine and phenylephrine.
Isoprenaline and dexmedetomidine did not induce apoptosis markers, such as
internucleosomal DNA fragmentation and caspase-3 activation, but induced a smear
pattern of DNA fragmentation in OSCC cell lines. Their cytotoxicity was not reduced
by pretreatment with autophagy inhibitors, or by adrenoceptors antagonists.
Addition of superoxide dismutase and catalase significantly reduced the
cytotoxicity of isoprenaline, but not that of dexmedetomidine. Conclusion:
Isoprenaline and dexmedetomidine induce non-apoptotic cell death by different
mechanisms.
AN - rayyan-563560209
AU - Uchida, S.
AU - Kobayashi, K.
AU - Ohno, S.
AU - Sakagami, H.
AU - Kohase, H.
AU - Nagasaka, H.
DO - 10.21873/anticanres.13498
IS - 7
KW - 3 methyladenine
bafilomycin A1
caspase 3
catalase
clonidine
dexmedetomidine
DNA
epinephrine
isoprenaline
phenylephrine
propranolol
yohimbine
apoptosis
article
CC50 (cytotoxic concentration)
cell death
cells by body anatomy
controlled study
DNA fragmentation
drug cytotoxicity
drug mechanism
drug specificity
enzyme activation
enzyme activity
enzyme substrate
fibroblast
gingiva
gingival fibroblast
hek a cell line
hek n cell line
HL-60 cell line
HSC-2 cell line
HSC-3 cell line
HSC-4 cell line
human
human cell
keratinocyte cell line
normal human
oral squamous cell carcinoma cell line
periodontal ligament fibroblast
priority journal
proapoptotic activity
protein cleavage
pulp cell
T98G cell line
U-87MG ATCC cell line
LA - English
PY - 2019
SN - ["1791-7530", "0250-7005"]
SP - 3519-3529
ST - Induction of non-apoptotic cell death by adrenergic agonists in human oral
squamous cell carcinoma cell lines
TI - Induction of non-apoptotic cell death by adrenergic agonists in human oral
squamous cell carcinoma cell lines
VL - 39
ID - 13583
ER -
TY - JOUR
AB - Periodontitis, similar to other infectious diseases, is known to progress as
chronic inflammation with recurrent acute phases. The purpose of this study was to
clarify the microbiological composition of the acute phase and to compare the
bacterial flora with that of comparable chronic periodontal pockets. We also
evaluated the effect of application of minocycline gel locally on the change in the
microflora in the acute pockets. Microbial flora from the subgingival pockets of 28
patients in the acute phase of periodontitis and of 12 patients in a comparable
chronic phase as the control were investigated by various bacterial culture methods
including TS blood agar and TSBV plates. Minocycline gel was applied to the acute
periodontal pockets. Changes in the microbiological proportion and clinical
parameters at one week after baseline examination were followed by dark-field
analysis, culture method, and indirect immunofluorescence technique. Characteristic
features of bacterial proportions in the acute site were observed as an increase in
Bacteroides forsythus. The number of Porphyromonas gingivalis and black pigmented
anaerobic rods also increased. Application of minocycline gel in the acute pocket
without any debridement produced improvement in clinical symptoms at one week.
Black-pigmented anaerobic rods, P. gingivalis, and B. forsythus decreased
significantly at one week after the application. Results indicate that
periodontopathic bacteria including B. forsythus and P. gingivalis were predominant
in the acute phase of periodontitis and a locally delivered antibiotic may be
effective as an alternative modality of treating the acute inflammation.
AN - rayyan-563561066
AU - Umeda, M.
AU - Tominaga, Y.
AU - He, T.
AU - Yano, K.
AU - Watanabe, H.
AU - Ishikawa, I.
DO - 10.1902/jop.1996.67.4.422
IS - 4
KW - minocycline
adult
article
bacterial flora
Bacteroides
clinical article
controlled study
female
gel
human
male
periodontitis
Porphyromonas
LA - English
PY - 1996
SN - 0022-3492
SP - 422-427
ST - Microbial flora in the acute phase of periodontitis and the effect of local
administration of minocycline
TI - Microbial flora in the acute phase of periodontitis and the effect of local
administration of minocycline
VL - 67
ID - 14440
ER -
TY - JOUR
AB - The clinical effects of subgingivally placed 1% chlorhexidine gel (w/w) and
40% tetracycline (w/w) paste in periodontal pockets of 22 adult periodontitis
patients were studied. The 2 agents were applied following scaling and root planing
in pockets exceeding 4 mm. The patients were randomly divided into 3 groups: (a)
scaling and root planing (SCRP) only, the control group; (b) corsodyl gel+SCRP; (c)
Tetracycline paste+SCRP. Gel or paste were gently applied using a syringe with a
blunt needle until the selected pocket was overfilled. Evaluations were made of
clinical parameters including the plaque index (PI), gingival index (GI), bleeding
index (GI-S), probing pocket depths, probing attachment levels and position of the
gingival margin. The results suggested that all the treatment modalities were
effective in producing statistically significant improvements in clinical
parameters. It was concluded that the conventional treatment modalities were
essential in the treatment of periodontal diseases, but in view of the structure of
the periodontal pocket and adjacent complex root surface, subgingival drug
application in certain cases, might also provide adjunctive improvement.
AN - rayyan-563561080
AU - Unsal, E.
AU - Akkaya, M.
AU - Walsh, T. F.
IS - 5
KW - chlorhexidine
drug derivative
tetracycline
adult
article
clinical trial
comparative study
controlled study
female
human
male
middle aged
periodontics
periodontitis
tooth plaque
LA - English
PY - 1994
SN - 0303-6979
SP - 351-355
ST - Influence of a single application of subgingival chlorhexidine gel or
tetracycline paste on the clinical parameters of adult periodontitis patients
TI - Influence of a single application of subgingival chlorhexidine gel or
tetracycline paste on the clinical parameters of adult periodontitis patients
VL - 21
ID - 14454
ER -
TY - JOUR
AB - Twenty-six (26) patients, 18 female and 7 male, aged 16 to 25 years (mean age
19.03 ± 2.2 years) previously diagnosed as suffering from localized juvenile
periodontitis were randomly assigned to one of the following treatment groups: 9
patients acted as controls; 8 received subgingival chlorexidine gel; and 9 had
subgingival tetracycline paste application. All treatment modalities resulted in a
pronounced improvement in PI, GI, and GI-S by 12 weeks (P < 0.001). The mean
probing depths also decreased, but there were no significant differences found
between the three groups. However, when the interproximal sites of the 3 groups
were examined separately from the buccal and lingual sites, it was found that there
was a significant (P < 0.05) difference between the probing depths, with the
control group showing the greatest reduction of 2.58 mm and the chlorhexidine group
showing the least reduction of 1.37 mm. It was concluded that a single application
of topical subgingival tetracycline did not result in any short-term improvement
over that achieved by standard non-surgical therapy in the clinical parameters of
these localized juvenile periodontitis patients.
AN - rayyan-563561072
AU - Unsal, E.
AU - Walsh, T. F.
AU - Akkaya, M.
DO - 10.1902/jop.1995.66.1.47
IS - 1
chlorhexidine
tetracycline
adolescent
adult
article
clinical article
female
human
male
periodontitis
LA - English
PY - 1995
SN - 0022-3492
SP - 47-51
ST - The effect of a single application of subgingival antimicrobial or mechanical
therapy on the clinical parameters of juvenile periodontitis
TI - The effect of a single application of subgingival antimicrobial or mechanical
therapy on the clinical parameters of juvenile periodontitis
VL - 66
ID - 14446
ER -
TY - JOUR
AB - TWENTY-SIX (26) PATIENTS, 18 FEMALE AND 7 MALE, aged 16 to 25 years (mean age
19.03 +/- 2.2 years) previously diagnosed as suffering from localized juvenile
periodontitis were randomly assigned to one of the following treatment groups: 9
patients acted as controls; 8 received subgingival chlorexidine gel; and 9 had
subgingival tetracycline paste application. All treatment modalities resulted in a
pronounced improvement in PI, GI, and GI-S by 12 weeks (P <0.001). The mean probing
depths also decreased, but there were no significant differences found between the
three groups. However, when the interproximal sites of the 3 groups were examined
separately from the buccal and lingual sites, it was found that there was a
significant (P <0.05) difference between the probing depths, with the control group
showing the greatest reduction of 2.58 mm and the chlorhexidine group showing the
least reduction of 1.37 mm. It was concluded that a single application of topical
subgingival tetracycline did not result in any short-term improvement over that
achieved by standard non-surgical therapy in the clinical parameters of these
localized juvenile periodontitis patients.
AN - rayyan-563562307
AU - Unsal, E.
AU - Walsh, T. F.
AU - Akkaya, M.
IS - 1
PY - 1995
SN - 0022-3492
SP - 47-51
ST - THE EFFECT OF A SINGLE APPLICATION OF SUBGINGIVAL ANTIMICROBIAL OR MECHANICAL
THERAPY ON THE CLINICAL-PARAMETERS OF JUVENILE PERIODONTITIS
TI - THE EFFECT OF A SINGLE APPLICATION OF SUBGINGIVAL ANTIMICROBIAL OR MECHANICAL
THERAPY ON THE CLINICAL-PARAMETERS OF JUVENILE PERIODONTITIS
VL - 66
Y2 - 1
ID - 15681
ER -
TY - JOUR
AB - The periodontal pack is often used to cover the surgical site after surgery,
even when associated with local applications of preparations containing
chlorexidine, in order to obtain an antiseptic protection. However many people
question whether the drug effectively succeeds in penetrating the pack, or if the
presence of the pack itself doesn't obstruct the action of the medication. The aim
of this work is to evaluate the efficiency of the clorexidine in the surgical area
with and without a periodontal pack. In a first stage, a case was chosen and
contemporary operated on in two different but anatomically similar sites at the
same time. One of the two sites was covered with a chlorexidine gel for the
following week, whilst the other was left without medication. After seven days the
stitches removed from the two different sites were placed in culture mediums to
number and classify the bacterial strains present. In the second stage of the
experiment, another eight patients were operated on in the same way, and the two
sites covered with periodontal packs. In one of the two sites a layer of
chlorexidine gel was positioned under the pack, and the chlorexidine above and on
the sides of the pack was continually renewed throughout the week following the
operation. The other site was not treated. The results obtained show that the pack
partially reduces the action of the drug medication, probably because an
insufficient amount reaches the site. The activity and efficiency of chlorexidine
against the strains of bacteria found in vivo were tested in vitro. The
chlorexidine destroyed all of them.(ABSTRACT TRUNCATED AT 250 WORDS)
AN - rayyan-563561151
AU - Urbani, G.
AU - Filippini, P.
AU - Lombardo, G.
AU - Consolo, U.
AU - Cuzzolin, L.
AU - Benoni, G.
IS - 10
KW - chlorhexidine
article
bacterium
comparative study
drug effect
drug screening
gel
human
microbiology
periodontic device
periodontium
surgical infection
suture
tooth plaque
LA - Italian
PY - 1992
SN - 0026-4970
SP - 435-443
ST - In vivo and in vitro experimentation with the effects of chlorhexidine in
patients who have undergone a periodontal intervention
T2 - Sperimentazione in vivo ed in vitro degli effetti della clorexidina in
pazienti sottoposti ad intervento parodontale.
TI - In vivo and in vitro experimentation with the effects of chlorhexidine in
patients who have undergone a periodontal intervention
VL - 41
ID - 14525
ER -
TY - JOUR
AB - Background/purpose: The aim of this study was to characterize the
Staphylococcus aureus strains isolated from periodontal lesions of patients, to
determine the expression of genes involved in cell adhesion upon their infection of
human epithelial cells using an in vitro model, its biofilm formation, and its
resistance to antibiotics. Methods: S. aureus was analysed by PCR, Kirby–Bauer, and
pulsed-field gel electrophoresis (PFGE), measuring gene expression by real-time PCR
after infection of human cells in vitro. Results: S. aureus was identified in 18.6%
(50/268) of the samples. All strains (n = 50) possessed the virulence genes spa
(Staphylococcal protein A), coa (coagulase), and icaAB (intercellular adhesin); 96%
(n = 48) possessed clfB (clumping factor B), and 88% (n = 44) possessed ebps
(elastin-binding protein) and sdrD (serine aspartate repeat protein D). All strains
were resistant to methicillin, ampicillin, dicloxacillin, cefotaxime, and
penicillin, and were multidrug resistant to 6–12 antibiotics. PFGE analysis showed
37 different pulsed-field types and most strains (60.4%) had a unique pulsed-field
type. Twenty-four distinct combinations of virulence genes and antibiotic-resistant
phenotypes were identified. Conclusion: Although S. aureus has been considered a
transient member of the oral microbiota, our results indicate a high-level
expression of virulence genes and multidrug resistance in the strains isolated from
periodontal lesions. These strains might complicate the successful treatment of the
disease.
AN - rayyan-563560000
AU - Uribe-García, A.
AU - Paniagua-Contreras, G. L.
AU - Monroy-Pérez, E.
AU - Bustos-Martínez, J.
AU - Hamdan-Partida, A.
AU - Garzón, J.
AU - Alanís, J.
AU - Quezada, R.
AU - Vaca-Paniagua, F.
AU - Vaca, S.
DO - 10.1016/j.jmii.2019.05.010
IS - 2
KW - CHEF DR II
electrophoresis analyzer
laboratory device
nucleic acid purification robot
QuantiTec
Rotor Gene SYBR Green
spectrophotometer
ampicillin
cefalotin
cefepime
cefotaxime
cefuroxime
coenzyme A
cotrimoxazole
dicloxacillin
erythromycin
gentamicin
levofloxacin
meticillin
pefloxacin
RNA 23S
tetracycline
A-549 cell line
analytic method
article
bacterial gene
bacterial strain
bacterial virulence
bacterium isolate
bbp gene
biofilm
cell adhesion
clfb gene
cna gene
disease severity
ebps gene
female
fnba gene
fnbb gene
gene expression
gingivitis
human
human cell
icaab gene
in vitro study
kirby bauer method
limit of quantitation
male
map eap gene
melting point
Mexico City
pathogenesis
periodontitis
phenotype
restriction fragment
RNA purification
sdrc gene
sdrd gene
sdre gene
spa gene
spectrophotometry
NanoDrop 2000
QIAcube
RNeasy Mini Kit
LA - English
PY - 2021
SN - ["1995-9133", "1684-1182"]
SP - 267-275
ST - Frequency and expression of genes involved in adhesion and biofilm formation
in Staphylococcus aureus strains isolated from periodontal lesions
T2 - J. Microbiol. Immunol. Infect.
TI - Frequency and expression of genes involved in adhesion and biofilm formation
in Staphylococcus aureus strains isolated from periodontal lesions
VL - 54
ID - 13374
ER -
TY - JOUR
AB - In a double blind crossover trial of a chlorhexidine gel on 40 subjects,
ranging from 2 to 19 yr old, 20 received applications of 0.5% chlorhexidine
gluconate once every weekday for 3 wk and a placebo gel was then substituted; the
remaining 20 received the placebo gel for 3 wk followed by the application of the
trial gel for 3 wk. Each subject acted as his own control. The gingival and debris
scores were recorded before the commencement of the study, after the first phase of
applications of chlorhexidine or placebo gels, immediately following the second
phase and 3 wk after cessation of gel applications. The debris scores were reduced
considerably following application of the chlorhexidine gel. The gingival
inflammation was also reduced. As no change in the oral hygiene regimen or scaling
was carried out prior to gel applications the effect of the chlorhexidine was
thought to be less dramatic than if scaling and prophylaxis had been carried out.
AN - rayyan-563561209
AU - Usher, P. J.
IS - 6
KW - chlorhexidine
child
clinical trial
controlled study
human
hygiene
mental deficiency
mouth cavity
mouth hygiene
periodontal disease
therapy
LA - English
PY - 1975
SP - 217-221
ST - Oral hygiene in mentally handicapped children. A pilot study of the use of
chlorhexidine gel
T2 - BRIT.DENT.J.
TI - Oral hygiene in mentally handicapped children. A pilot study of the use of
chlorhexidine gel
VL - 138
ID - 14583
ER -
TY - JOUR
AB - Dental caries and periodontal disease are responsible for the most frequent
set of chronic diseases in humans, for which no perfectly regenerative solutions
are available yet. As a result, materials combining an intrinsic antibacterial
activity with tissue regeneration properties for minimally invasive dental
therapies are in high demand. Here we report on the fabrication and
characterization of a novel nanocomposite material for such dental applications.
The material is composed of narrowly disperse Na2O-CaO-P2O5-SiO2 bioglass-ceramic
nanoparticles, 30-70 nm in diameter, doped with antibacterial and osteogenic zinc
and niobium ions, and hybridized with chitosan. These systems were characterized
for their particle size, morphology, atomic and phase composition, and glass-
ceramic/polymer interface with the use of transmission electron microscopy, energy-
dispersive X-ray analysis, X-ray diffraction and Fourier transform infrared
spectroscopy. After annealing at 680 degrees C, amorphous silica in the bioglass-
ceramic coexisted with silicalite-1 and combeite, the average crystallite size of
which was 20-40 nm. In spite of the significantly better incorporation of zinc than
of niobium inside the glass-ceramic network, zinc did not affect the particle size
and shape distribution, while niobium lowered the average particle size. Chitosan
increased the hydration capacity of the bioglass-ceramic and it formed a continuous
interface around the bioglass-ceramic nanoparticles, devoid of micropores. This
intimacy of the interface was confirmed by the downshift of the critical Si-O(-Si)
vibration modes in the bioglass-ceramic upon hybridization with chitosan. The
addition of zinc ions hampered the partial recrystallization during annealing by
interfering with the Si-O network restructuring, in direct proportion with its
concentration. Niobium ions produced a similar structure-breaking effect, which was
evidenced, as in the case of zinc, by upshifting the antisymmetric Si-O-Si stretch
of the bridging oxygen and increasing the full-width at half maxima for all the
major Si-O(-Si) vibration modes. The effective electrostatic attraction between the
aminated hydrocarbon chains of chitosan and the negatively charged silanol groups
of silica may extend to the interaction with dentin collagen fibrils decalcified
due to caries, making the material of potential interest for adhesive fillers of
cariogenic lesions in teeth. Both the undoped and the doped bioactive glass-
ceramics interacted favorably with odontoblast-like cells, accentuating their
potential for further research for applications in minimally invasive reparative
dentistry.
AN - rayyan-563562606
AU - Uskokovic, V.
AU - Abuna, G.
AU - Ferreira, P.
AU - Wu, V. M.
AU - Gower, L.
AU - Pires-de-Souza, F. C. P.
AU - Murata, R. M.
AU - Sinhoreti, M. A. C.
AU - Geraldeli, S.
DO - 10.1007/s10971-020-05442-5
IS - 2
PY - 2021
SN - ["0928-0707", "1573-4846"]
SP - 245-258
ST - Synthesis and characterization of nanoparticulate niobium- and zinc-doped
bioglass-ceramic/chitosan hybrids for dental applications
T2 - JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
TI - Synthesis and characterization of nanoparticulate niobium- and zinc-doped
bioglass-ceramic/chitosan hybrids for dental applications
VL - 97
Y2 - 2
ID - 15980
ER -
TY - JOUR
AB - BACKGROUND AND OBJECTIVE: Pathogenic bacteria cause degeneration of
periodontal tissues, which is essential for the reduction of gingival bacteria in
order to reduce scaling and leveling. But there is no perfect treatment in pockets
with a depth of more than 4 mm. Therefore, this study was conducted to investigate
the effect of chlorhexidine gel as a topical supplementation after scaling and
leveling the root surface in the treatment of moderate to advanced periodontitis.
METHODS: This tripartite clinical trial was performed on 31 patients with chronic
periodontitis, each with at least four pockets of depth of 4 to 6 mm. 62 areas as
controls and 62 regions of the experimental group were selected randomly. In all
patients, scaling and leveling of the root surface were done. In the experimental
group, in addition to the scaling and leveling, the chlorhexidine gel surface was
injected into the pockets. In four steps, before treatment, 2, 3 and 6 months after
treatment, the clinical parameters of gingival index, bleeding index, plaque index,
adhesion index and probe index depth index were measured and recorded.
(IRCT:1R1N2013081314350). FINDINGS: The plaque index, bleeding index, gingival
index and pocket probe depth in the group receiving the topical gel of
chlorhexidine showed a significant difference in all levels of measurement compared
to the control group (PI: control group was 2. 75±0. 44 and case group was 1. 94±0.
38, p=0. 000, BI: The control group was 1. 0±0. 5, the case group was 0. 05±0. 44,
p=0. 000, PPD: the control group was 4. 62±0. 73, the case group was 3. 88±0. 83,
p=0. 000, GI: The control group was 1. 77±0. 42, case group was 1. 18±0. 18,
p=0.000). CONCLUSION: The results showed that injection of chlorhexidine gel with
scaling and leveling of the root surface resulted in a greater improvement in
periodontal clinical indices than SRP alone.
AN - rayyan-563560300
AU - Vadiati Saberi, B.
AU - Radafshar, G.
AU - Khanjani, N.
AU - Fathi, S.
IS - 5
KW - IR1N2013081314350
chlorhexidine
adhesion index
adult
article
case control study
clinical article
clinical trial
controlled study
dental parameters
dental scaling
depth index
drug efficacy
follow up
gingival index
gingivitis
human
plaque index
pocket probe depth index
probe index
retrospective study
tooth plaque
LA - English
PY - 2017
SN - ["2251-7170", "1561-4107"]
SP - 74-80
ST - Effect of topical gel chlorhexidine 0.2% on non-surgical treatment of chronic
periodontitis
T2 - J. Babol Univ. Med. Sci.
TI - Effect of topical gel chlorhexidine 0.2% on non-surgical treatment of chronic
periodontitis
VL - 19
ID - 13674
ER -
TY - JOUR
AB - Background/Aim: In some parts of the world, revascularization may not be the
most feasible treatment option for necrotic immature teeth. Therefore,
apexification remains the most widely utilized treatment option for these cases.
This study aimed to evaluate the fracture resistance of weakened bovine tooth roots
treated with various irrigant solutions as well as long-term application of calcium
hydroxide intracanal medication (ICM). Material and methods: One hundred seventy
bovine teeth were randomly divided into three experimental groups (n = 50) and two
control groups (n = 10). Group SS was irrigated with physiologic solution; group
CHX was treated with 2% chlorhexidine gel and group NaOCl was irrigated with 1%
sodium hypochlorite. After instrumentation, root canals were dressed with calcium
hydroxide and evaluated at different periods (15, 60, 90, 180, and 360 days). The
specimens were loaded at a 45 degrees angle to measure fracture resistance through
the use of an EMIC test machine. Results: A decrease in fracture resistance was
observed during the time of ICM dressing. The highest values of fracture resistance
were observed in group SS with 15 days of ICM, not differing from the control
group. Irrigation with NaOCl associated with ICM for 15 days presented the lowest
fracture resistance; however, a statistically significant difference was not
observed when compared with SS and CHX in the same time period. In longer periods
of exposure to ICM (180 and 360 days), root canals irrigated with NaOCl and CHX
showed significantly lower fracture resistance than SS (P < 0.05). Conclusion:
Apexification with periodic changes of calcium hydroxide medicament leads to
weakness of the teeth independent of the irrigation solution used.
AN - rayyan-563562638
AU - Valera, M. C.
AU - Yamasaki, M. C.
AU - Vassallo, F. N. S.
AU - da Silva, Daesa
AU - Nagata, J. Y.
DO - 10.1111/edt.12185
IS - 5
PY - 2015
SN - ["1600-4469", "1600-9657"]
SP - 385-389
ST - Fracture resistance of weakened bovine teeth after long-term use of calcium
hydroxide
T2 - DENTAL TRAUMATOLOGY
TI - Fracture resistance of weakened bovine teeth after long-term use of calcium
hydroxide
VL - 31
Y2 - 10
ID - 16012
ER -
TY - BOOK
AN - rayyan-563561911
AU - Vallittu, P. K.
DO - 10.1533/9780857096432
PY - 2012
SP - 1-406
ST - Non-metallic biomaterials for tooth repair and replacement
T2 - Non-Metallic Biomaterials for Tooth Repair and Replacement
TI - Non-metallic biomaterials for tooth repair and replacement
84902432397&doi=10.1533%2f9780857096432&partnerID=40&md5=e17f6678d49f2581de879cf010
cff851
ID - 15285
ER -
TY - JOUR
AB - A CLASSICAL TREATMENT FOR CHRONIC ADULT PERIODONTITIS consists Of four to six
consecutive sessions of scaling and root planing at a 1- to 2-week interval. Such a
so-called "quadrant or sextant therapy" might result in a reinfection of a
previously disinfected area by bacteria from an untreated region. The purpose of
this study was to investigate, over an 8-month period, the clinical benefits of
full-mouth disinfection within a 24-hour period in the control of chronic
periodontitis. Ten adult patients with advanced chronic periodontitis were randomly
assigned to a test and a control group. The control group received the standard
scheme of initial periodontal therapy, consisting of scaling and root planing per
quadrant at 2-week intervals. In the full-mouth disinfection group, scaling and
root planing of the four quadrants was performed within 24 hours and immediately
followed by a thorough supra- and subgingival chlorhexidine application to limit
any transfer of bacteria. The latter involved tongue brushing with a 1%
chlorhexidine gel for 60 seconds, mouthrinsing with a 0.2% chlorhexidine solution
twice for 60 seconds, repeated subgingival irrigation of all pockets with a 1%
chlorhexidine gel (3 times within 10 minutes), and mouthrinsing twice daily with a
0.2% chlorhexidine solution during 2 weeks. In addition, both groups received
thorough oral hygiene instructions. The plaque index, gingival index, probing
depth, gingival recession, and bleeding on probing were recorded prior to
professional cleaning and at 1, 2, 4, and 8 months afterwards. Although the test
group scored higher plaque indices than the control group, especially at months 2
and 4, the gingival index and bleeding tendency showed similar improvements with
time. However, when the gingival/plaque ratio was considered, the latter was lower
in the test group at all follow-up visits. For pockets greater than or equal to 7
mm, full-mouth disinfection showed a significantly (P = 0.01) higher reduction in
probing depth at each follow-up visit with, at month 8, a reduction of 4 mm (from 8
mm to 4 mm), in comparison to 3 mm (from 8 mm to 5 mm) for the classical therapy.
The increase in gingival recession in the full-mouth disinfection group remained
below 0.7 mm, while in the control group it reached 1.9 mm after 8 months. This
resulted in a gain of clinical attachment level of 3.7 mm for the test group versus
1.9 mm for the control group. A radiographical examination also indicated a
superior improvement for the test group. when compared to the control group. This
pilot study suggests that a full-mouth disinfection in one day results in an
improved clinical outcome in chronic periodontitis as compared to scalings per
quadrant at 2-week intervals over several weeks.
AN - rayyan-563562402
AU - Vandekerchkove, B. N. A.
AU - Dekeyser, C.
AU - Darius, P.
AU - Quirynen, M.
DO - 10.1902/jop.1996.67.12.1251
IS - 12
PY - 1996
SN - ["0022-3492", "1943-3670"]
SP - 1251-1259
infections. Long-term clinical observations of a pilot study
VL - 67
Y2 - 12
ID - 15776
ER -
TY - JOUR
AB - A classical treatment for chronic adult periodontitis consists of four to six
consecutive sessions of scaling and root planing at a 1- to 2-week interval. Such a
so-called 'quadrant or sextant therapy' might result in a reinfection of a
previously disinfected area by bacteria from an untreated region. The purpose of
this study was to investigate, over an 8-month period, the clinical benefits of
full-month disinfection within a 24-hour period in the control of chronic
periodontitis. Ten adult patients with advanced chronic periodonitis were randomly
assigned to a test and control group. The control group received the standard
scheme of initial periodontal therapy, consisting of scaling and root planing per
quadrant at 2-week intervals. In the full-mouth disinfection group, scaling and
root planing of the four quadrants was performed within 24 hours and immediately
followed by a thorough supra- and subgingival chlorhexidine application to limit
any transfer of bacteria. The latter involved tongue brushing with a 1%
chlorhexidine gel for 60 seconds, mouthrinsing with a 0.2% chlorhexidine solution
twice for 60 seconds, repeated subgingival irrigation of all pockets with a 1%
chlorhexidine gel (3 times within 10 minutes), and mouthrinsing twice daily with a
0.2% chlorhexidine solution during 2 weeks. In addition, both groups received
thorough oral hygiene instructions. The plaque index, gingival index, probing
depth, gingival recession, and bleeding on probing were recorded prior to
professional cleaning and at 1, 2, 4, and 8 months afterwards. Although the test
group scored higher plaque indices than the control group, especially at months 2
and 4, the gingival index and bleeding tendency showed similar improvements with
time. However, when the gingival/plaque ratio was considered, the latter was lower
in the test group at all follow-up visits. For pockets ≤ 7 mm, full-mouth
disinfection showed a significantly (P = 0.01) higher reduction in probing depth at
each follow-up visit with, at month 8, a reduction of 4 mm (from 8 mm to 4 mm), in
comparison to 3 mm (from 8 mm to 5 mm) for the classical therapy. The increase in
gingival recession in the full-mouth disinfection group remained below 0.7 mm,
while in the control group it reached 1.9 mm after 8 months. This resulted in a
gain of clinical attachment level of 3.7 mm for the test group versus 1.9 mm for
the control group. A radiographical examination also indicated a superior
improvement for the test group when compared to the control group. This pilot study
suggests that a full-mouth disinfection in one day results in an improved clinical
outcome in chronic periodontitis as compared to scalings per quadrant at 2-week
intervals over several weeks.
AN - rayyan-563561053
AU - Dekeyser, C.
AU - Darius, P.
AU - Quirynen, M.
DO - 10.1902/jop.1996.67.12.1251
IS - 12
KW - chlorhexidine
adult
article
clinical article
clinical trial
controlled study
disinfection
female
follow up
human
male
mouth hygiene
pain
periodontitis
reinfection
treatment outcome
corsodyl
LA - English
PY - 1996
SN - 0022-3492
SP - 1251-1259
VL - 67
ID - 14427
ER -
TY - JOUR
AB - Oral health surveys have shown that even in countries with established
patterns of oral hygiene habits, most individuals have relatively poor gingival
health. This is due to a low interest in complying with oral health procedures. A
number of factors are apparent when investigating compliance to oral hygiene
habits, viz only approximately 50% of the population brushes twice a day or more,
brushing time is probably much too short and use of dental floss is not very
prevalent. Studies of the effect of motivation on oral hygiene suggest that
improvements can be achieved, but these are not maintained unless motivation is
continuously reinforced. This suggests that topically applied antiplaque agents
should be used to augment mechanical plaque control. A number of product forms are
available to delivery anti-plaque agents i.e., mouthrinses, dentifrices, aqueous
gels, and additionally floss, chewing gum and lozenges. Any product form should
provide a physically, chemically and microbiologically stable environment for the
agent concerned. It should facilitate optimal bioavailability of the agents at the
site of action and encourage patient compliance. Antiplaque agents for topical
administration should have the following properties: high intrinsic efficacy
against a broad spectrum of oral organisms, toxicological and ecological safety,
oral substantivity, no adverse reactions and good chemical stability. A number of
classes of anti-plaque agents have been identified such as positively charged
organic molecules, metal salts, phenols, enzymes, peroxides, sugar substitues,
fluorides and surface modifying agents. In order to achieve optimal
bioavailability, the agent to be dosed should be compatible with the product form
used. The 2 major product forms are rinses and dentifrices. With respect to rinses
as the product form, the formulation excipients are generally compatible with
positively charged organic agents, phenolic agents and some metal salts. In the
case of dentrifice formulations, interactions of the agent with the product
excipients limit compatibility to some metal salts and non-charged phenolic agents,
triclosan being a well researched example. The combination of metal salts, in
particular zinc, and the phenolic agent triclosan has been shown to represent a
further powerful route to enhance systems for daily plaque control.
AN - rayyan-563562513
AU - Vanderouderaa, F. J. G.
IS - 6
PY - 1991
SN - ["0303-6979", "1600-051X"]
SP - 447-454
ST - ANTI-PLAQUE AGENTS - RATIONALE AND PROSPECTS FOR PREVENTION OF GINGIVITIS AND
PERIODONTAL-DISEASE
TI - ANTI-PLAQUE AGENTS - RATIONALE AND PROSPECTS FOR PREVENTION OF GINGIVITIS AND
PERIODONTAL-DISEASE
VL - 18
Y2 - 7
ID - 15887
ER -
TY - JOUR
AB - Gelatin methacryloyl (GelMA) hydrogels have been widely used for different
biomedical applications due to their tunable physical characteristics and
appropriate biological properties. In addition, GelMA could be modified with the
addition of functional groups providing inherent antibacterial capabilities. Here,
GelMA-based hydrogels were developed through the combination of a GelMA unmodified
and modified polymer with quaternary ammonium groups (GelMAQ). The GelMAQ was
synthesized from GelMA with a low degree of substitution of methacrylamide groups
(DSMA) and grafted with glycidyltrimethylammonium chloride in the free amine groups
of the lysine moieties present in the original gelatin. GelMAs with high DSMA and
GelMAQ were combined 50/50% or 25/75% (w/w), respectively, and compared to controls
GelMA and GelMA with added chlorhexidine (CHX) at 0.2%. The different hydrogels
were characterized using (1)H-NMR spectroscopy and swelling behavior and tested in
(1) Porphyromonas gingivalis to evaluate their antibacterial properties and (2)
human gingival fibroblast to evaluate their cell biocompatibility and regenerative
properties. GelMA/GelMAQ 25/75% showed good antibacterial properties but also
excellent biocompatibility and regenerative properties toward human fibroblasts in
the wound healing assay. Taken together, these results suggest that the
modification of GelMA with quaternary groups could facilitate periodontal tissue
regeneration, with good biocompatibility and added antibacterial properties.
AN - rayyan-563560940
AU - Vargas-Alfredo, N.
AU - Munar-Bestard, M.
AU - Ramis, J. M.
AU - Monjo, M.
DO - 10.3390/gels8100630
IS - 10
J2 - Gels
LA - eng
N1 - Cell Therapy and Tissue Engineering Group, Department of Fundamental Biology
and Health Sciences, Research Institute on Health Sciences (IUNICS), University of
the Balearic Islands, Ctra. Valldemossa Km 7.5, 07122 Palma de Mallorca, Spain.;
Health Research Institute of the Balearic Islands (IdISBa), Ctra. Valldemossa 79,
University Hospital Son Espases, Edificio S, 07120 Palma de Mallorca, Spain.; Cell
Therapy and Tissue Engineering Group, Department of Fundamental Biology and Health
Sciences, Research Institute on Health Sciences (IUNICS), University of the
Balearic Islands, Ctra. Valldemossa Km 7.5, 07122 Palma de Mallorca, Spain.; Health
Research Institute of the Balearic Islands (IdISBa), Ctra. Valldemossa 79,
University Hospital Son Espases, Edificio S, 07120 Palma de Mallorca, Spain.
PY - 2022
ST - Synthesis and Modification of Gelatin Methacryloyl (GelMA) with Antibacterial
Quaternary Groups and Its Potential for Periodontal Applications
TI - Synthesis and Modification of Gelatin Methacryloyl (GelMA) with Antibacterial
Quaternary Groups and Its Potential for Periodontal Applications
VL - 8
Y2 - 10 y3 - 5
ID - 14314
ER -
TY - JOUR
AB - To develop a localized drug delivery system that offers prolonged
administration of metronidazole into the periodontal pocket, muc-coadhesive gel
formulations containing 5% w/w metronidazole were prepared using the bioadhesive
polymers: carboxymethylcellulose, methylcellulose, hydroxyethylcellulose,
polyvinylpirrolidone, and carbopol. Increased concentrations of the polymers
decreased the drug release rate and enhanced syringeability, yield value, and
adhesiveness but decreased the spreadability. The bioadhesive properties of the
gels were affected by pH and Ca2+ concentration. The gel containing 20%
hydroxyethylcellulose, 20% polyvinylpirrolidone, and 1% carbopol exhibited zero-
order drug release kinetics and suitable physical properties for drug delivery to
the periodontal pocket.
AN - rayyan-563560901
AU - Varshosaz, J.
AU - Tavakoli, N.
AU - Saidian, S.
DO - 10.1080/10426500290095601
IS - 2
KW - adhesive agent
calcium ion
carbomer
methylcellulose
metronidazole
polymer
povidone
adhesion
article
drug formulation
drug release
gel
periodontic device
pH
physical parameters
priority journal
spreadability
syringeability
LA - English
PY - 2002
SN - 1071-7544
SP - 127-133
ST - Development and physical characterization of a periodontal bioadhesive gel of
metronidazole
T2 - Drug Deliv. J. Deliv. Targeting Ther. Agents
TI - Development and physical characterization of a periodontal bioadhesive gel of
metronidazole
VL - 9
ID - 14275
ER -
TY - JOUR
AB - Guided tissue regeneration (GTR) is a dentistry technique based on the use of
polymeric biomembranes as physical barriers for selective cell exclusion, directing
the growth of gingival tissue, bone tissue, and periodontal ligaments in a region
previously affected by periodontitis. Postoperative pain and microbial infection
constitute, however, two major challenges to be tackled right after implantation.
To address these challenges, we prepared and characterized eight
chitosan/hyaluronic acid/glycerol (CS/HA/GL) bioresorbable membranes embedded with
lidocaine- and chloramphenicol-loaded polycaprolactone nanoparticles (LDNP and
CHNP, respectively), combining the local anesthetic effects of lidocaine with the
antibacterial effects of chloramphenicol. The formulations were prepared with
varying amounts of CS, HA, GL, LDNP, and CHNP. As a plasticizing agent, GL could
modulate the samples mechanical properties such as thickness, morphology, tensile
strength, elongation at break, as well as swelling and degradation in simulated
saliva. Two samples exhibited greater resistance to biodegradation and were
selected for further studies. Their drug release profiles indicated that LDNP and
CHNP first detach from the membrane matrix, and a zeroth order drug release
kinetics from the detached NPs dominates the overall process thereafter, with
lidocaine being released 3 times faster than chloramphenicol, in a controlled and
sustained rate over time. Drug encapsulation efficiency was such that optimal
samples exhibited bactericidal activity (inhibition halos) against gram-positive S.
aureus and gram-negative A. actinomycetemcomitans strains similar to that observed
for free chloramphenicol. Finally, one of these samples showed no intrinsic
toxicity against healthy mammalian model cells (99% viability for the unloaded
membrane; 80% viability for the fully LDNP- and CHNP-loaded membrane), and may now
be further optimized as a drug-eluting biomembrane with potential for GTR.
AN - rayyan-563562531
AU - Vasconcelos, M. O.
AU - Silva, L. A. D.
AU - Sousa, A. A.
AU - dos Santos, T. R. M.
AU - da Silva, C. A.
AU - Valadares, M. C.
AU - Lima, E. M.
DO - 10.3389/fnano.2022.1049599
PY - 2022
SN - 2673-3013
ST - Lidocaine- and chloramphenicol-loaded nanoparticles embedded in a
chitosan/hyaluronic acid/glycerol matrix: Drug-eluting biomembranes with potential
for guided tissue regeneration
T2 - FRONTIERS IN NANOTECHNOLOGY
TI - Lidocaine- and chloramphenicol-loaded nanoparticles embedded in a
chitosan/hyaluronic acid/glycerol matrix: Drug-eluting biomembranes with potential
for guided tissue regeneration
VL - 4
Y2 - 11 y3 - 11
ID - 15905
ER -
TY - CHAP
AN - rayyan-563561685
AU - Vasques, A. M. V.
AU - Matheus, H. R.
AU - Gusman, D. J. R.
AU - Cury, M. T. S.
AU - dos Reis-Prado, A. H.
AU - Quintino Trizzi, J.
AU - Emerenciano Bueno, C. R.
PY - 2020
SP - 191-226
ST - Phytotherapy in periodontics
T2 - Contemporary Use of Plant Extracts in Dentistry: Scientific Evidence for
Phytotherapy and Ethnopharmacology
TI - Phytotherapy in periodontics
85146317729&partnerID=40&md5=d12fc52f03090f9742a9230b56e2fd10
ID - 15059
ER -
TY - JOUR
AN - rayyan-563561658
AU - Velichko, E. V.
AU - Vasil'Ev, Yu L.
DO - 10.37988/1811-153X_2022_4_64
IS - 4
PY - 2022
SP - 64-72
ST - Peculiarities of selection of modern adhesive medications for treatment of
inflammatory periodontal and oral mucosa diseases
T2 - Clinical Dentistry (Russia)
TI - Peculiarities of selection of modern adhesive medications for treatment of
inflammatory periodontal and oral mucosa diseases
85150042255&doi=10.37988%2f1811-
153X_2022_4_64&partnerID=40&md5=b6eecd9b254e66a1e2903a3f0465e0ac
VL - 25
ID - 15032
ER -
TY - JOUR
AB - Periodontal diseases are chronic inflammatory disease in which microbial
factors, host factors, environmental and genetic factors play a significant role in
causing the disease. In that dental plaque is considered as the primary etiologic
agent and it exists in a state of bio film. Plaque contains microorganisms which
provoke inflammatory reaction from the host leading to connective tissue
destruction, pocket formation and bone loss. Treatment options include surgical and
non-surgical periodontal therapy. For mild to moderate periodontitis non-surgical
methods are preferred. Non-surgical methods include scaling, root planing and anti-
microbial therapy. Since periodontal pathogens reside inside the tissues, use of
antimicrobials as adjunct to scaling and root planing is highly recommended.
Antimicrobials can be delivered locally and systemically. Use of local drug
delivery systems for treating periodontitis offers several advantages. This article
discusses the various anti microbials used in treating periodontitis which are
delivered as local drug delivery agent.
AN - rayyan-563560559
AU - Venkatesh Dr, A.
AU - Ramamurthy Dr, J.
IS - 1
chlorhexidine
doxycycline
metronidazole
microsphere
minocycline
ofloxacin
tetracycline
adjuvant therapy
article
biofilm
bleeding
chronic disease
connective tissue
drug efficacy
drug mechanism
drug safety
fiber
follow up
gel
human
inflammation
molar tooth
mouth hygiene
multicenter study (topic)
osteolysis
periodontal pocket
periodontitis
prognosis
smoking
therapy effect
tissue injury
tooth plaque
treatment duration
treatment outcome
elyzol
LA - English
PY - 2012
SN - 0975-1491
SP - 30-37
ST - Local drug delivery systems in the treatment of periodontitis - an overview
TI - Local drug delivery systems in the treatment of periodontitis - an overview
VL - 4
ID - 13933
ER -
TY - JOUR
AB - Periodontitis is an inflammatory condition affecting teeth resulting in
progressive destruction of periodontal ligaments, resorption of alveolar bone and
loss of teeth. Treatment of periodontitis includes surgical and non surgical
management. Systemic antibiotics are also used for the treatment of periodontitis.
The aim of this research was to formulate smart gel system of azithromycin (AZT)
and to evaluate in vitro and in vivo for non-surgical treatment of chronic
periodontitis. Azithromycin dihydrate, used systemically in the treatment of
periodontitis, was formulated into smart gels using biodegradable, thermosensitive
polymer Pluronic® F-127 (PF-127) and Hydroxy Ethyl Cellulose (HEC) as copolymer.
The prepared smart gels were evaluated for sterility, content uniformity, gelation
temperature and time, syringeability, rheological behavior, in vitro diffusion and
in vivo efficacy in human patients. The prepared smart gels were clear and
transparent, sterile, thermoresponsive and injectable. Viscosity of gels increased
with increase in concentration of polymer/co-polymer and also with temperature.
They gelled in short response time below the body temperature. In vitro release
studies showed controlled drug release which was influenced significantly by the
properties and concentration of PF-127 and HEC. In vivo efficacy studies showed a
significant improvement (p<0.001) in clinical parameters such as gingival index,
probing pocket depth, clinical attachment level, bleeding index and plaque index.
The developed azithromycin smart gel system is a novel approach for the treatment
of chronic periodontitis since it reduces the dose and side effects, bypasses the
usual surgical procedures and improves patient compliance. © 2013 Bentham Science
Publishers.
AN - rayyan-563560483
AU - Pramod Kumar, T. M.
AU - Avinash, B. S.
AU - Sheela Kumar, G.
DO - 10.2174/1567201811310020005
IS - 2
KW - azithromycin
copolymer
adult
article
blood rheology
body temperature
clinical article
controlled study
drug diffusion
drug efficacy
drug formulation
drug response
drug screening
drug sterility
female
gel
gelation
gingiva
heat sensitivity
human
in vitro study
in vivo study
male
mouth plaque
oral bleeding
periodontal pocket
priority journal
viscosity
LA - English
PY - 2013
SN - ["1567-2018", "1875-5704"]
SP - 188-197
ST - Development, in vitro and in vivo evaluation of novel injectable smart gels
of azithromycin for chronic periodontitis
TI - Development, in vitro and in vivo evaluation of novel injectable smart gels
of azithromycin for chronic periodontitis
VL - 10
ID - 13857
ER -
TY - JOUR
AB - AIM: The aim of this research was to assess the binding of fibrin clot to the
teeth affected by periodontal disease following exposure to different root
conditioning agents. MATERIALS AND METHODS: A total of 60 human teeth with a
solitary root that were subjected to extraction following severe periodontal
disease were used as study samples in this research. Two analogous grooves were
prepared on the proximal radicular surface of every sample employing a diamond-
tapered fissure bur using an aerator handpiece beneath abundant irrigation. Every
sample was assigned to one of the following groups: • Group I: Tetracycline
hydrochloride solution • Group II: Ethylenediaminetetraacetic acid (EDTA) gel •
Group III: Biopure MTAD™ Subsequent to conditioning, the samples were rinsed for 3
minutes with phosphate-buffered saline (PBS) and permitted to air-dry for 20
minutes. A drop of fresh human whole blood procured from a hale and hearty
volunteer was coated onto the dentin blocks in all three groups. A scanning
electron microscope under 5000× magnification at 15 kV was used to examine the
samples. Kruskal-Wallis test and Mann-Whitney U test were performed to procure the
inter- and intragroup assessments Results: The greatest fibrin clot union was noted
in the EDTA gel group at 2.86 ± 0.14 in pursuit by Biopure MTAD™ group at 2.39 ±
0.08 as well as tetracycline hydrochloride solution group at 1.82 ± 0.10. A
statistically significant difference was noted between the investigational groups
(p < 0.001). CONCLUSION: This research arrived at a conclusion that the dentinal
surfaces subjected to conditioning with EDTA gel group as well as coated with human
whole blood resulted in appreciably superior fibrin clot bonding to dentin vs
Biopure MTAD™ as well as the tetracycline hydrochloride solution group. CLINICAL
SIGNIFICANCE: Connective tissue attachment subsequent to surgical procedures
causing the adhesion of a fibrin clot to the radicular surface as a result of
initial wound healing processes is directly related to periodontal regeneration. It
depends on biocompatibility for the fibrin clot and the periodontal pathosis-
affected radicular surface to stick together, which can be procured with the aid of
a variety of root conditioning measures in course of periodontal treatment.
AN - rayyan-563559809
AU - Verma, A.
AU - Raj, K.
AU - Satyanarayan, A.
AU - Archana, D.
AU - Anand, K.
AU - Nath, B.
DO - 10.5005/jp-journals-10024-3372
IS - 9
KW - edetic acid
fibrin
tetracycline
cell adhesion
dental surgery
dentin
human
periodontitis
thrombosis
tooth root
LA - English
PY - 2022
SN - 1526-3711
SP - 895-899
ST - A Scanning Electron Microscope Evaluation of the Adhesion of Fibrin Clot to
the Periodontally Compromised Teeth after Exposed to Different Root-conditioning
Agents: An In Vitro Study
TI - A Scanning Electron Microscope Evaluation of the Adhesion of Fibrin Clot to
the Periodontally Compromised Teeth after Exposed to Different Root-conditioning
Agents: An In Vitro Study
VL - 23
ID - 13183
ER -
TY - JOUR
AB - OBJECTIVES: The aim of this study was to evaluate the efficacy of
subgingivally administered xanthan-based chlorhexidine gel when used in the
maintenance phase following scaling and root planing (SRP) in the treatment of
chronic periodontitis. MATERIALS AND METHODS: A randomized, controlled, single-
center study was conducted involving 92 sites in 46 systemically healthy patients
suffering from moderate to advanced chronic periodontitis with isolated pockets.
The selected sites were randomized to two treatment arms: Group A (SRP alone) and
Group B (SRP + insertion of chlorhexidine gel after 1 month). The gingival index,
plaque index, probing pocket depth (PPD) and clinical attachment level (CAL) were
recorded at baseline and subsequently after 1 month and 3 months. RESULTS: Both the
groups showed significant reductions in PPD and CAL at both follow-up visits when
compared with the baseline values (P<0.001). CONCLUSIONS: The results suggest that
the application of xanthan based chlorhexidine gel following SRP in the maintenance
phase might be beneficial in treatment of the chronic periodontitis in comparison
to SRP alone. Greater improvements may be achieved when antimicrobial agents are
used following SRP.
AN - rayyan-563561361
AU - Verma, A.
AU - Sanghi, S.
AU - Grover, D.
AU - Aggarwal, S.
AU - Gupta, R.
AU - Pandit, N.
DO - 10.4103/0972-124X.100916
IS - 3
LA - eng
N1 - Department of Periodontology, Manav Rachna Dental College, Faridabad,
Haryana, India.
PY - 2012
SP - 381-5
ST - Effect of insertion of xanthan-based chlorhexidine gel in the maintenance
phase following the treatment of chronic periodontitis
TI - Effect of insertion of xanthan-based chlorhexidine gel in the maintenance
phase following the treatment of chronic periodontitis
VL - 16
Y2 - 7
ID - 14735
ER -
TY - JOUR
AB - Aim: A randomized controlled clinical trial was conducted to evaluate the
effect of local drug delivery (LDD) of Acmella oleracea (Akarkara) and Acacia
catechu (kattha) gels as an adjunct to scaling and root planing (SRP) in
generalized chronic periodontitis patients. Materials and Methods: Thirty patients
with ninety sites aged 25-65 years with generalized chronic periodontitis having
pocket probing depth (PPD) of more than or equal to 5 mm on the basis of inclusion
and exclusion criteria were selected. They were treated according to split-mouth
design protocol. The placement of gel containing A. oleracea (1%) (Group 1) and A.
catechu (1%) (Group 2) as LDD was placed at the two test sites, respectively, and
only SRP was done in the control group (Group 3). Periodontal dressing was applied
to all the three sites after procedure, and patients were given oral care
guidelines. Evaluation of clinical parameters gingival index (GI), plaque index
(PI), gingival bleeding index (GBI), PPD, clinical attachment level (CAL), and
relative attachment level (RAL) was done at baseline, 1, 3, and 6 months, and
microbiological parameter was assessed at baseline and 6 months. N-benzoyl-DL-
arginine-2-napthylamide (BANA) test was used for the microbiological analysis.
Results: Clinical parameters from baseline to 6 months at different time intervals
demonstrated a significant reduction in mean GI, PI, GBI, and PPD and gain in CAL
and RAL over a period of 6 months, and results were statistically significant in
all the three treatment groups. However, on intergroup comparison, clinically
significant difference was observed, but statistically, results were significant at
few intervals. The microbiological analysis revealed a statistically nonsignificant
reduction at the end of 6 months on intra- and intergroup comparison. Conclusion:
The study concluded that the use of A. catechu gel and A. oleracea gel clinically
showed improvement in clinical parameters when combined with SRP, attributing to
better anti-inflammatory and healing properties.
AN - rayyan-563559861
AU - Verma, K.
AU - Dhruvakumar, D.
AU - Pande, M.
DO - 10.4103/jisp.jisp-264-21
IS - 3
KW - insulin syringe
Acacia catechu extract
Acmella oleracea extract
antiinfective agent
plant extract
unclassified drug
Acmella oleracea
adult
aged
article
Asteraceae
clinical article
controlled study
dental scaling
drug efficacy
drug formulation
drug isolation
follow up
gelation
gingival index
human
mouth flora
mouth hygiene
plaque index
root planing
Senegalia catechu
treatment response time
LA - English
PY - 2022
SN - ["0975-1580", "0972-124X"]
SP - 254-261
ST - A clinical and microbiological study to assess the efficacy of Acmella
oleracea and Acacia catechu herbs as local drug delivery in treatment of chronic
generalized periodontitis patients
TI - A clinical and microbiological study to assess the efficacy of Acmella
oleracea and Acacia catechu herbs as local drug delivery in treatment of chronic
generalized periodontitis patients
VL - 26
ID - 13235
ER -
TY - JOUR
AB - This study evaluated the protective effect of TiF4 varnish, after pre-
treatment with proantocyanidin or chlorhexidine, on the progression of erosive
dentin loss (EDL), under the presence or absence of the demineralized organic
matrix (DOM). Bovine root dentin samples were eroded for 30 min (0.1% citric acid,
pH 2.5) and the loss was measured by profilometry. Half of them were subjected to
the DOM removal using collagenase for 4 days, while the other half remained
immersed in water. The removal of DOM was checked by profilometry. Samples were
divided into 24 groups (n = 15) according to the factors: 1– With or without DOM;
2– Pre-treatment with 0.012% chlorhexidine gel, 10% proanthocyanidin gel or
untreated for 1 min; 3–Final Treatment with TiF4 varnish, NaF varnish, placebo
varnish or untreated for 6 h. The samples were submitted to a pH cycling for 5
days: 0.1% citric acid (4 × 90s/day) and artificial saliva between the challenges.
The final profile was obtained for the calculation of EDL (μm, three-way
ANOVA/Tukey test). When DOM was preserved, the EDL was lower compared to the
condition without DOM (7.08 ± 4.03 μm and 9.80 ± 3.79 μm, p < 0.001, respectively),
regardless of the treatments. The pre-treatment had no influence on the progression
of EDL (p = 0.637), while the final treatment (TiF4 varnish only, 6.77 ± 4.08 μm)
was effective in reducing the progression of EDL (NaF varnish: 9.52 ± 4.02 μm;
Placebo varnish: 8.64 ± 4.06 μm and no treatment: 8.80 ± 3.95 μm). It can be
concluded that DOM has important protective effect on the progression of EDL. TiF4
was the unique treatment capable of reducing EDL progression, regardless of the
pre-treatment of DOM.
AN - rayyan-563560017
AU - Vertuan, M.
AU - Souza, B. M.
AU - Mosquim, V.
AU - Silva, C. V.
AU - Freitas, P. M.
AU - Borges, A. F. S.
AU - Rios, D.
AU - Magalhães, A. C.
AU - Honório, H. M.
DO - 10.1016/j.jmbbm.2020.104287
KW - chlorhexidine
citric acid
collagenase
demineralized organic matrix
dental material
fluoride varnish
gel
proanthocyanidin
saliva substitute
titanium
unclassified drug
article
bovine
controlled study
dentin
enamel
in vitro study
incisor
nonhuman
periodontal disease
pH
priority journal
tooth disease
varnish
LA - English
PY - 2021
SN - ["1878-0180", "1751-6161"]
ST - Effect of TiF4 varnish after pre-treatment with proanthocyanidin or
chlorhexidine on the progression of erosive dentin loss in the presence or absence
of the demineralized organic matrix
T2 - J. Mech. Behav. Biomed. Mater.
TI - Effect of TiF4 varnish after pre-treatment with proanthocyanidin or
chlorhexidine on the progression of erosive dentin loss in the presence or absence
of the demineralized organic matrix
VL - 115
ID - 13391
ER -
TY - JOUR
AB - Background: The name of chitosan comes from greek meaning breastplate.
Chitosan is produced by chitin deacetylation, which is a linear polysaccharide
ramdomly made of de b-(1-4) D-glucosamine and N-acetil-D-glucosamine strains,
naturally present at crustacean exoskeleton (crabs, prawns, lobsters . . .), and
also insects. Amino Group has a pKa value around 6'5, that's why it is soluble in
acid or neutral media, depending on the pH. So it works as bioadhesive, including
the ability to band to negatively charged surfaces, as mucous membranes. Due to
this characteristic, polar active principles are allowed to being transported to
epithelial surface in a biocompatible and biodegradable way. Case report: A 26-
years-old woman, referred sporadic oral and pharyngeal pruritus as well as lips
hypoesthesia, after shrimp, prawn (both fresh and frozen) or selfish paella
ingestion. She tolerates cephalopods as calamari or octopus. Also doing the
housework, she related rhinoconjunctivitis and dyspnoea. Skin prick test (SPT) were
positive to Dermatophagoides pteronyssinus (3 × 3 mm), Dermatophagoides farinae (5
× 5 mm) and cockroach (3 × 2 mm). Prick-to-prick were performed, being positive to
shrimp (4 × 3 mm) and prawn (5 × 4 mm). SPT was negative to Anisakis. Immuno CAPs
(TermoFisher Scientific, Massatchusetts, USA) to prawn was 1.08 KU/L, D.
pteronyssinus 0.45 KU/L, D. farinae 0.50 KU/L and Blatella germanica 0.66 KU/L. So
we started treatment with antihistamine, inhaled Budesonide 200 mcg/12 h, and
crustacean avoidance. Several months later, she came to our department telling
immediately gum angioedema after using a mouthwash. Prick-to-prick was positive to
mouthwash (3 × 3 mm). Looking for its composition, figured 'Chitosan'. Results:
Bexident Post®: (Mouthwash or topic gel). Helps to reduce inflammation and protect
the gums and oral mucosa during periodontal, preimplantation treatments and
maxilofacial surgery. Chitosan regenerates and repairs tissues, accelerating the
healing process. Composition: Chitosan, Chlorhexidine 0.2%, Allantoin and
Bioadhesive excipient. Conclusion: The mouthwash used by the patient, contents
chitosan, a polysaccharide obtained from crustaceans. During the production
process, it may sweep along crustacean traces, so our shellfish allergic patient
reacted against them. Further in vitro studies may be performance to know more
about this new polysaccharide, in order to advice our patients about hidden
sources.
AN - rayyan-563560339
AU - Veza, S.
AU - Rodríguez, B.
AU - Muñoz, E.
AU - Kindelan, C.
AU - Morales, M. L.
AU - González, J. M.
AU - Cachero, M.
DO - 10.1111/all.12979
KW - acid
allantoin
allergen
antihistaminic agent
budesonide
chitin
chitosan
chlorhexidine
excipient
mouthwash
adult
angioneurotic edema
animal experiment
animal model
Anisakis
avoidance behavior
Blattella germanica
crab
deacetylation
dentist
Dermatophagoides farinae
Dermatophagoides pteronyssinus
drug solubility
dyspnea
exoskeleton
exposure
female
housekeeping
human
hypesthesia
in vitro study
ingestion
lip
lobster
mouth mucosa
nonhuman
octopus
oral pruritus
pH
pKa
prick test
rhinoconjunctivitis
shellfish
shrimp
surgery
LA - English
PY - 2016
SN - 1398-9995
SP - 596
ST - Hidden food allergens at the dentist?
T2 - Allergy Eur. J. Allergy Clin. Immunol.
TI - Hidden food allergens at the dentist?
VL - 71
ID - 13713
ER -
TY - COMP
AB - BACKGROUND/AIM: The purpose of this study was to detect bacterial species and
to quantify the total number of bacteria from samples of infected root canals
before (S1) and after chemo-mechanical preparation using 2% chlorhexidine (CHX) gel
as auxiliary chemical substance (S2) and after 7 days of intracanal dressing (S3)
to compare microbial changes. METHOD: Twenty-four teeth were selected for this
study. Chemo-mechanical preparation was performed using 2% CHX gel, then three
different intracanal medicaments [M1: Ca(OH)(2) paste; M2: 2% CHX gel; and M3:
Ca(OH)(2) paste plus 2% CHX gel] were used for 7 days. Checkerboard DNA-DNA
hybridization was performed to detect 40 bacterial species. Aerobic and anaerobic
culture techniques were used to determine the bacterial community by counting the
colony-forming units (CFU). RESULTS: The species most frequently identified by
checkerboard in S1 were: Fusobacterium nucleatum ssp. polymorphum, Treponema
socranskii ssp. socranskii, Parvimonas micra and Enterococcus faecalis. In S2 and
S3 a total of eight different species were identified; and only one of them was
gram-positive (E. faecalis). Microorganisms were not identified after use of M2 for
7 days. The quantification obtained on agar plates ranged from 4 x 10(5) to 2.6 x
10(6) CFU/ml in S1, mean CFU was reduced by 99.96% in S2, and there was no
statistical difference between the CFU in S2 and S3. CONCLUSION: The antibacterial
effect of the mechanical preparation supplemented by the use of an antibacterial
auxiliary substance greatly reduced the microorganisms in the main root canal.
AN - rayyan-563561286
AU - Vianna, M. E.
AU - Horz, H. P.
AU - Conrads, G.
AU - Feres, M.
AU - Gomes, B. P.
CY - Denmark
DO - 10.1111/j.1399-302X.2007.00425.x
ET - 4
J2 - Oral Microbiol Immunol
KW - Adolescent
Adult
Anti-Infective Agents, Local/administration & dosage/therapeutic use
Bacteria/*classification/genetics
Calcium Hydroxide/administration & dosage/therapeutic use
Campylobacter/classification
Capnocytophaga/classification
Chlorhexidine/administration & dosage/therapeutic use
DNA, Bacterial/analysis
Dental Pulp Cavity/*microbiology
Dental Pulp Necrosis/*microbiology/therapy
Drug Combinations
Enterococcus faecalis/classification
Eubacterium/classification
Fusobacterium nucleatum/classification
Humans
Middle Aged
Nucleic Acid Hybridization
Periapical Periodontitis/microbiology/therapy
Root Canal Irrigants/administration & dosage/therapeutic use
Root Canal Preparation/methods
Streptococcus/classification
Treponema/classification
LA - eng
N1 - Department of Restorative Dentistry, Endodontic Division, Piracicaba Dental
School, State University of Campinas - UNICAMP, Piracicaba, SP, Brazil.
PY - 2008
SP - 282-90
ST - Comparative analysis of endodontic pathogens using checkerboard hybridization
in relation to culture
T2 - Oral microbiology and immunology
TI - Comparative analysis of endodontic pathogens using checkerboard hybridization
VL - 23
Y2 - 8
ID - 14660
ER -
TY - JOUR
AN - rayyan-563561959
AU - Vianna, M. E.
AU - Horz, H. P.
AU - Conrads, G.
AU - Feres, M.
DO - 10.1111/j.1399-302X.2007.00425.x
IS - 4
PY - 2008
SP - 282-290
ST - Comparative analysis of endodontic pathogens using checkerboard hybridization
T2 - Oral Microbiology and Immunology
TI - Comparative analysis of endodontic pathogens using checkerboard hybridization
45149107253&doi=10.1111%2fj.1399-
302X.2007.00425.x&partnerID=40&md5=f718699c0d3c0f5d0ef61a5317a69d0b
VL - 23
ID - 15333
ER -
TY - JOUR
AB - Background/aims: The purpose of this study was to determine the amount of
endotoxin (lipopolysaccharide) and cultivable bacteria in human necrotic root
canals before (S 1) and after chemo-mechanical preparation using chlorhexidine
(CHX) gel as auxiliary chemical substance (S2), and after 7 days of intracanal
dressing (S3) in order to evaluate the antiendotoxin and antimicrobial effects of
endodontic procedures. Method: Twenty-four teeth were selected for the present
study. Chemo-mechanical preparation was performed using 2% CHX gel and three
different intracanal medicaments [Ca(OH)(2) paste; 2% CHX gel; and Ca(OH)(2) + 2%
CHX gel]. A quantitative chromogenic Limulus amoebocyte lysate assay was used to
measure the amount of endotoxin. Aerobic and anaerobic techniques were used to
isolate and identify bacteria, and to determine the bacterial reduction by counting
colony-forming units (CFU). Results: Endotoxins and bacteria were present in 100%
of the initial samples, with endotoxin concentration ranging from 62.93 to 214.56
UE/ml and CFU ranging from 4 x 10(5) to 2.6 x 10(6). After chemo-mechanical
preparation a mean endotoxin reduction of 44.4% was found. Fight (33.3%) root
canals were still positive by culture analysis with a mean reduction of bacteria
(CFU) of 99.96%. After 7 days of intracanal dressing, endotoxin concentration
decreased by only 1.4% compared with S2, and residual bacteria were recovered by
culture analysis in 13 cases (54.1%). No significant difference was found among
different intracanal medicaments. Conclusion: Relatively high values of endotoxin
were still present in the root canal after chemo-mechanical preparation although
the majority of bacteria were eliminated. No improvement was achieved by 7 days of
intracanal dressing.
AN - rayyan-563562602
AU - Vianna, M. E.
AU - Horz, H. P.
AU - Conrads, G.
AU - Zaia, A. A.
AU - Souza, F. J.
AU - Gomes, Bpfa
DO - 10.1111/j.1399-302X.2007.00379.x
IS - 6
PY - 2007
SN - 0902-0055
SP - 411-418
ST - Effect of root canal procedures on endotoxins and endodontic pathogens
TI - Effect of root canal procedures on endotoxins and endodontic pathogens
VL - 22
Y2 - 12
ID - 15976
ER -
TY - JOUR
AB - Aim To determine in vivo, the degree of microbial reduction after chemo-
mechanical preparation of human root canals containing necrotic pulp tissue when
using two endodontic irrigating reagents, sodium hypochlorite (NaOCl) or
chlorhexidine gel (CHX). Methodology Thirty-two single rooted teeth with necrotic
pulp were divided into two groups. One group (n=16) was irrigated with 2.5% NaOCl,
whilst the other group (n=16) was irrigated with 2% CHX gel. Assessment of the
bacterial load was accomplished by use of real-time quantitative-polymerase chain
reaction (RTQ-PCR) directed against the small subunit ribosomal DNA using the
SYBRGreen and TaqMan formats. Statistical analysis was performed using the Mann-
Whitney test. For contrast, bacterial load was also determined by traditional
culture techniques. Results The bacterial load was reduced substantially in both
groups (over 96%). However, using RTQ-PCR the bacterial load before and after
chemo-mechanical preparation was greater when compared with evaluation using colony
forming units (CFU). Furthermore, as measured by RTQ-PCR, the bacterial reduction
in the NaOCl-group (SYBRGreen 99.99%; TaqMan: 99.63%) was significantly greater (P
< 0.01) than in the CHX-group (SYBRGreen 96.62%; TaqMan: 96.60%). According to
culture technique 75% of cases were free of bacteria after chemo-mechanical
preparation in the NaOCl-group, whilst 50% of cases were bacteria free in the CHX-
group. Conclusion NaOCl has not only a higher capacity to kill microorganisms but
is also more able to remove cells from the root canal.
AN - rayyan-563562601
AU - Vianna, M. E.
AU - Horz, H. P.
AU - Gomes, Bpfa
AU - Conrads, G.
DO - 10.1111/j.1365-2591.2006.01121.x
IS - 6
PY - 2006
SN - ["0143-2885", "1365-2591"]
SP - 484-492
of human root canals containing necrotic pulp tissue
of human root canals containing necrotic pulp tissue
VL - 39
Y2 - 6
ID - 15975
ER -
TY - JOUR
AB - Periodontitis is a chronic, multifactorial, inflammatory disease
characterized by the progressive destruction of the periodontal tissues. Guided
tissue regeneration (GTR), involving the use of barrier membranes, is one of the
most successful clinical procedures for periodontal therapy. Nevertheless, rapid
degradation of the membranes and membrane-related infections are considered two of
the major reasons for GTR clinical failure. Recently, integration of non-
antibiotic, antimicrobial materials to the membranes has emerged as a novel
strategy to face the bacterial infection challenge, without increasing bacterial
resistance. In this sense, bismuth subsalicylate (BSS) is a non-antibiotic, metal-
based antimicrobial agent effective against different bacterial strains, that has
been long safely used in medical treatments. Thus, the aim of the present work was
to fabricate fibrillar, non-rapidly bioresorbable, antibacterial GTR membranes
composed of polycaprolactone (PCL), gelatin (Gel), and BSS as the antibacterial
agent. PCL-G-BSS membranes with three different BSS concentrations (2 wt./v%, 4
wt./v%, and 6 wt./v%) were developed by electrospinning and their morphology,
composition, water wettability, mechanical properties, Bi release and degradation
rate were characterized. The Cytotoxicity of the membranes was studied in vitro
using human osteoblasts (hFOB) and gingival fibroblasts (HGF-1), and their
antibacterial activity was tested against Aggregatibacter actinomycetemcomitans,
Escherichia coli, Porphyromonas gingivalis and Staphylococcus aureus. The membranes
obtained exhibited adequate mechanical properties for clinical application, and
appropriate degradation rates for allowing periodontal defects regeneration. The
hFOB and HGF-1 cells displayed adequate viability when in contact with the
lixiviated products from the membranes, and, in general, displayed antibacterial
activity against the four bacteria strains tested. Thus, the PCL-G-BSS membranes
showed to be appropriate as potential barrier membranes for periodontal GTR
treatments.
AN - rayyan-563559979
AU - Vidal-Gutiérrez, X.
AU - Rodil, S. E.
AU - Clemente, I.
DO - 10.1088/1748-605X/ac058d
IS - 4
KW - dental tissue regeneration membrane
antiinfective agent
bismuth salicylate
gelatin
polycaprolactone
article
bacterial membrane
bacterium
biodegradation
cell proliferation
cell viability
chemical interaction
contact angle
controlled study
cytotoxicity
degradation
electrospinning
enthalpy
Escherichia coli
hFOB 1.19 cell line
HGF-1 cell line
human
human cell
in vitro study
inductively coupled plasma mass spectrometry
mechanics
melting temperature
nonhuman
pore size
thermogravimetry
thermostability
turbidity
water contact angle
wettability
Young modulus
LA - English
PY - 2021
SN - ["1748-605X", "1748-6041"]
ST - Bismuth subsalicylate incorporated in polycaprolactone-gelatin membranes by
electrospinning to prevent bacterial colonization
T2 - Biomed. Mater.
TI - Bismuth subsalicylate incorporated in polycaprolactone-gelatin membranes by
VL - 16
ID - 13353
ER -
TY - JOUR
AB - Periodontitis is a chronic, multifactorial, inflammatory disease
characterized by the progressive destruction of the periodontal tissues. Guided
tissue regeneration (GTR), involving the use of barrier membranes, is one of the
most successful clinical procedures for periodontal therapy. Nevertheless, rapid
degradation of the membranes and membrane-related infections are considered two of
the major reasons for GTR clinical failure. Recently, integration of non-
antibiotic, antimicrobial materials to the membranes has emerged as a novel
strategy to face the bacterial infection challenge, without increasing bacterial
resistance. In this sense, bismuth subsalicylate (BSS) is a non-antibiotic, metal-
based antimicrobial agent effective against different bacterial strains, that has
been long safely used in medical treatments. Thus, the aim of the present work was
to fabricate fibrillar, non-rapidly bioresorbable, antibacterial GTR membranes
composed of polycaprolactone (PCL), gelatin (Gel), and BSS as the antibacterial
agent. PCL-G-BSS membranes with three different BSS concentrations (2 wt./v%, 4
wt./v%, and 6 wt./v%) were developed by electrospinning and their morphology,
composition, water wettability, mechanical properties, Bi release and degradation
rate were characterized. The Cytotoxicity of the membranes was studied in vitro
using human osteoblasts (hFOB) and gingival fibroblasts (HGF-1), and their
antibacterial activity was tested against Aggregatibacter actinomycetemcomitans,
Escherichia coli, Porphyromonas gingivalis and Staphylococcus aureus. The membranes
obtained exhibited adequate mechanical properties for clinical application, and
appropriate degradation rates for allowing periodontal defects regeneration. The
hFOB and HGF-1 cells displayed adequate viability when in contact with the
lixiviated products from the membranes, and, in general, displayed antibacterial
activity against the four bacteria strains tested. Thus, the PCL-G-BSS membranes
showed to be appropriate as potential barrier membranes for periodontal GTR
treatments.
AN - rayyan-563562399
AU - Vidal-Gutierrez, X.
AU - Rodil, S. E.
AU - Clemente, I.
DO - 10.1088/1748-605X/ac058d
IS - 4
PY - 2021
SN - ["1748-6041", "1748-605X"]
ST - Bismuth subsalicylate incorporated in polycaprolactone-gelatin membranes by
TI - Bismuth subsalicylate incorporated in polycaprolactone-gelatin membranes by
VL - 16
Y2 - 7 y3 - 1
ID - 15773
ER -
TY - JOUR
AB - This work aimed to develop and evaluate pH-dependent systems based on
nanospheres (NSphs) and nanocapsules (NCs) loaded with chlorhexidine (CHX) base as
a novel formulation for the treatment of periodontal disease. Cellulose acetate
phthalate (CAP) was employed as a pH-dependent polymeric material. The NSphs and
NCs were prepared using the emulsion-diffusion technique and then characterized
according to encapsulation efficiency (EE), size, zeta-potential, morphology,
thermal properties, release profiles and a preliminary clinical panel test. The
formulations showed 77% and 61% EE and 57% and 84% process efficiency (PE),
respectively. Both systems were spherical with an average size of 250-300 nm.
Differential scanning calorimetry (DSC) studies showed that the drug has the
potential to be dispersed molecularly in the NSph matrix or dissolved in the oily
center of the NCs. The CHX release test revealed that the release of NSphs-CHX
follows Fickian diffusion involving diffusion-erosion processes. The NCs showed a
slower release than the NSphs, following non-Fickian diffusion, which is indicative
of anomalous transport. These nanosystems may, therefore, be employed as novel
formulations for treating periodontal disease, due to (1) their coverage of a large
surface area, (2) the controlled release of active substances at different pH, and
(3) potential gingival tissue infiltration.
AN - rayyan-563562486
AU - Vidal-Romero, G.
AU - Zambrano-Zaragoza, M. L.
AU - Martinez-Acevedo, L.
AU - Leyva-Gomez, G.
AU - Mendoza-Elvira, S. E.
AU - Quintanar-Guerrero, D.
IS - 11
PY - 2019
SN - 1999-4923
ST - Design and Evaluation of pH-Dependent Nanosystems Based on Cellulose Acetate
Phthalate, Nanoparticles Loaded with Chlorhexidine for Periodontal Treatment
T2 - PHARMACEUTICS
TI - Design and Evaluation of pH-Dependent Nanosystems Based on Cellulose Acetate
Phthalate, Nanoparticles Loaded with Chlorhexidine for Periodontal Treatment
VL - 11
Y2 - 11
ID - 15860
ER -
TY - JOUR
AN - rayyan-563561813
AU - Vijayashree Priyadharsini, J.
AU - Smiline Girija, A. S.
AU - Paramasivam, A.
DO - 10.1016/j.heliyon.2018.e01051
IS - 12
PY - 2018
ST - An insight into the emergence of Acinetobacter baumannii as an oro-dental
pathogen and its drug resistance gene profile – An in silico approach
T2 - Heliyon
TI - An insight into the emergence of Acinetobacter baumannii as an oro-dental
pathogen and its drug resistance gene profile – An in silico approach
85058639052&doi=10.1016%2fj.heliyon.2018.e01051&partnerID=40&md5=d134982e47ed316173
77647ec1506be9
VL - 4
ID - 15187
ER -
TY - JOUR
AB - Enamel matrix derivative is used to promote periodontal regeneration during
the corrective phase of the treatment of periodontal defects. Our main goal was to
analyze the bioactivity of different molecular weight fractions of enamel matrix
derivative. Enamel matrix derivative, a complex mixture of proteins, was separated
into 13 fractions using size-exclusion chromatography and characterized by sodium
dodecyl sulfate–polyacrylamide gel electrophoresis and liquid chromatography–
electrospray ionization–tandem mass spectrometry. Human periodontal ligament
fibroblasts were treated with either enamel matrix derivative or the different
fractions. Proliferation and cytokine secretion to the cell culture medium were
measured and compared to untreated cells. The liquid chromatography–electrospray
ionization–tandem mass spectrometry analyses revealed that the most abundant
peptides were amelogenin and leucine-rich amelogenin peptide related. The fractions
containing proteins above 20 kDa induced an increase in vascular endothelial growth
factor and interleukin-6 secretion, whereas lower molecular weight fractions
enhanced proliferation and secretion of interleukin-8 and monocyte chemoattractant
protein-1 and reduced interleukin-4 release. The various molecular components in
the enamel matrix derivative formulation might contribute to reported effects on
tissue regeneration through their influence on vascularization, the immune
response, and chemotaxis.
AN - rayyan-563560391
AU - Villa, O.
AU - Brookes, S. J.
AU - Thiede, B.
AU - Heijl, L.
AU - Lyngstadaas, S. P.
AU - Reseland, J. E.
DO - 10.1177/2041731415575857
KW - amelogenin
interleukin 4
interleukin 6
interleukin 8
vasculotropin
article
cell proliferation
controlled study
cytokine production
down regulation
enamel matrix
fibroblast
human
human cell
priority journal
tissue scaffold
upregulation
LA - English
PY - 2015
SN - 2041-7314
ST - Subfractions of enamel matrix derivative differentially influence cytokine
secretion from human oral fibroblasts
T2 - J. Tissue Eng.
TI - Subfractions of enamel matrix derivative differentially influence cytokine
secretion from human oral fibroblasts
VL - 6
ID - 13765
ER -
TY - JOUR
AB - Background: Oral lichen planus is a chronic inflammatory skin disease of
autoimmune nature, with infiltration of T lymphocytes that destroy the basal
stratum, which causes white striae, erosions, ulcers and breaks in epithelial
continuity. Case report: 54-year-old woman with multiple reticular and erosive
lesions in the region of the buccal mucosa and lateral borders of the tongue, as
well as desquamative gingivitis. Treatment with mometasone was started thrice daily
for 20 days and intermittently with miconazole gel to prevent iatrogenic mycosis by
the corticosteroid. The patient was examined at 20 days, after which 80 %
improvement of the lesions that had central ulcerations was observed, which allowed
the ingestion of food and fluids without pain and improved the quality of life.
Conclusions: In autoimmune diseases, clinical-histopathological correlation is
important for a definitive diagnosis to be established. Clinical follow-up of these
patients should be carried out in the long term, in order to achieve remission of
the lesions, control of the disease and avoid future complications.
AN - rayyan-563560270
AU - Villanueva-Sánchez, F. G.
AU - Escalante-Macías, L. H.
AU - Zambrano-Galván, G.
AU - Cuevas-González, J. C.
AU - Maya-García, I. A.
DO - 10.29262/ram.v65i4.342
IS - 4
KW - corticosteroid
miconazole
mometasone furoate
nucleotide
aged
case report
clinical article
drug intermittent therapy
female
follow up
gingivitis
histopathology
human
human tissue
lichen planus
mouth lesion
mycosis
quality of life
review
wound healing
LA - Spanish
PY - 2018
SN - ["2448-9190", "0002-5151"]
SP - 424-430
ST - Oral lichen planus. Case report and literature review
T2 - Liquen plano bucal. Reporte de un caso y revisión de la literatura
TI - Oral lichen planus. Case report and literature review
VL - 65
ID - 13644
ER -
TY - JOUR
AB - Aim: To clinically evaluate & compare the efficacy of 4% Mangosteen Gel and
1% chlorhexidine digluconate gel in managing patients with chronic gingivitis.
Materials and Methods: A total of 50 patients with an age group of 20-45 years
diagnosed with generalized plaque-induced gingivitis were selected for this
clinical trial once attaining their informed consent. A thorough case history was
chronicled comprising plaque index (P.I.), gingival index (G.I.) and Sulcus
bleeding index (SBI) at baseline; then full-mouth scaling and polishing (SAP) was
performed by a solitary attuned examiner. Patients were then randomly assigned into
two groups using a computer-generated random numbering sequence system. Patients in
group A received 4% Mangosteen Gel, and group B received 1% chlorhexidine
digluconate gel for home application. The post-treatment follow-up examination for
P.I., G.I. and SBI changes were assessed after 14 days and 21 days and compared
with baseline data. Results: In both the groups, the mean plaque index, gingival
index and sulcus bleeding index scores were significantly decreased after the 14th
and 21st day compared to baseline scores. There was no significant difference
between the groups, but only in group B, there was a substantial difference in SBI
scores observed on day 21. Conclusion: 4% Mangosteen Gel and 1% chlorhexidine
digluconate gel were clinically effective when used as an adjunct to SAP in
managing patients with gingivitis. Hence, 4% Mangosteen Gel can be considered an
alternative to 1% chlorhexidine digluconate gel without any side effects in
managing generalized plaque-induced gingivitis.
AN - rayyan-563559948
AU - Vinayaka, A. M.
AU - Gayathri, G. V.
AU - Triveni, M. G.
DO - 10.7897/2277-4343.1206161
IS - 1
gel
mangosteen gel
unclassified drug
adult
article
clinical article
drug efficacy
follow up
Garcinia mangostana
gingival index
gingivitis
human
plaque index
LA - English
PY - 2021
SN - ["2229-3566", "2277-4343"]
SP - 6-11
ST - COMPARATIVE EVALUATION OF THE EFFICACY OF 4% MANGOSTEEN GEL AND 1%
CHLORHEXIDINE DIGLUCONATE GEL IN MANAGEMENT OF PATIENTS WITH CHRONIC GINGIVITIS: A
RANDOMIZED CLINICAL TRIAL
T2 - Int. J. Res. Ayurveda Pharm.
TI - COMPARATIVE EVALUATION OF THE EFFICACY OF 4% MANGOSTEEN GEL AND 1%
CHLORHEXIDINE DIGLUCONATE GEL IN MANAGEMENT OF PATIENTS WITH CHRONIC GINGIVITIS: A
RANDOMIZED CLINICAL TRIAL
VL - 13
ID - 13322
ER -
TY - JOUR
AB - This study evaluates the effect of subgingival irrigation with a 1%
chlorhexidine collagen gel in periodontal pockets as an adjunct procedure to
scaling and root planing (SRP). Thirty-seven sites with probing depth (PD) of 5-7
mm and BANA positive in 6 patients with chronic periodontal disease were selected.
Sites were assigned to different treatment groups consisting of SRP only (group 1),
SRP + irrigation with collagen gel (group 2), or SRP + irrigation with collagen gel
containing 1% chlorhexidine (group 3). Subgingival irrigation was performed after
initial SRP and at 7, 14 and 21 days. Clinical measurements including PD, plaque
index (PI), gingival index (GI), gingival recession (GI), bleeding on probing (BOP)
and clinical attachment level (CAL) were performed at the selected sites at
baseline, 60 and 90 days and the BANA test was performed on plaque samples from the
same sites at baseline and 90 days. There was an improvement in clinical parameters
in all groups with a significantly greater decrease in GI and bleeding in the
chlorhexidine group. There was a greater reduction of BANA positive sites in groups
2 and 3. The authors concluded that 1% chlorhexidine collagen gel is a promising
adjunct to SRP in the treatment of adult periodontitis.
AN - rayyan-563560919
AU - Vinholis, A. H.
AU - Marcantonio Júnior, E.
AU - Marcantonio, R. A.
AU - Salvador, S. L.
AU - Goissis, G.
IS - 3
KW - chlorhexidine
collagen
n benzoylarginine 2 naphthylamide
adult
article
clinical trial
controlled study
female
gel
gingiva disease
human
lavage
male
middle aged
nonparametric test
periodontics
periodontitis
tooth plaque
treatment outcome
LA - English
PY - 2001
SN - 0103-6440
SP - 209-213
ST - Subgingival utilization of a 1% chlorhexidine collagen gel for the treatment
of periodontal pockets. A clinical and microbiological study
T2 - Braz Dent J
TI - Subgingival utilization of a 1% chlorhexidine collagen gel for the treatment
of periodontal pockets. A clinical and microbiological study
VL - 12
ID - 14293
ER -
TY - GEN
AB - O estudo comparou os efeitos clínicos e microbilógicos da raspagem e
alisamento radicular (RAR) com ou sem aplicação de gel de Metronidazol a 25
percento, em pacientes com doença periodontal crônica. Foram inclusos neste estudo
cego 11 pacientes com no mínimo 4 sítios em dentes unirradiculares com profundidade
de sondagem entre 5-8mm, sangramento à sondagem e BANA positivos. Após RAR, os 70
sítios foram distribuídos aleatoriamente entre os grupos: Grupo 1 - RAR; Grupo 2 -
RAR em associação com 2 irrigações com gel de Metronidazol a 25 percento, (Elyzol)
0 e 7 dias. Os parâmetros clínicos de profundidade de sondagem, sangramento à
sondagem, índice de placa, índice gengival e nível de inserção relativo foram
avaliados antes dos tratamentos, 30, 60 e 90 dias após, e a avaliação
microbiológica foi realizada com o Teste BANA antes e 90 dias após os tratamentos.
Os resultados demonstraram que ambos os tratamentos promoveram reduções
estatisticamente significantes em todos os parâmetros até o final do estudo...
AN - rayyan-563559887
AU - Vinholis, Adriana Helena Chicharo
LA - pt
PY - 2001
SP - 276-276
ST - Avaliação dos efeitos clínicos e microbiológicos da aplicação tópica de
Metronidazol à raspagem e alisamento radicular no tratamento da doença periodontal
crônica
TI - Avaliação dos efeitos clínicos e microbiológicos da aplicação tópica de
Metronidazol à raspagem e alisamento radicular no tratamento da doença periodontal
crônica
UR - https://pesquisa.bvsalud.org/portal/resource/pt/lil-467000
ID - 13261
ER -
TY - JOUR
AB - Plan: The present research has been undertaken with the aim to develop an
oral mucoadhessive gel for gingivitis and periodontitis, evaluation of its
physicochemical characteristics. Preface: Gingivitis and periodontitis require
prolonged medication which is challenging with the nature and anatomy of the oral
cavity. Here a sincere attempt was done to enhance the adhesion and contact time of
a developed oral adhesive medicament by virtue of its protective layer itself
should prevent abrasions, thus aiding in healing. Methodology: In the contemporary
work, effect of propolis, vitamin C and vitamin E on mucoadhessive nature of oral
adhesive dosage form intended for the treatment of gingivitis were investigated.
Oral mucoadhessive preparation was prepared by preparation of emulsion system and
incorporation into gel to form an emulgel. This emulgel was compared for its
physiochemical characterization with gel in the presence and absence of propolis
extract. The work was further enhanced by considering a combination of vitamin C
and E incorporated gel. Outcome: From the study it was concluded that excellent
mucoadhesion resulted by addition of propolis, vitamin C, vitamin E. Results
clearly indicated propolis because of mucoadhesion can augment the contact time of
the medicament with that of the oral cavity. Freeze thaw cycles of stability
Performa indicated the propolis-emulgel combination was stable for 8 cycles and
there was no globule size alteration, means no agglomeration tendency.
AN - rayyan-563560397
AU - Vinod, K. R.
AU - Jasmin, F.
AU - Park, J. W.
AU - Akalin, F. A.
AU - Choi, D. J.
DO - 10.15254/H.J.D.Med.7.2015.140
IS - 1
ascorbic acid
excipient
propolis
animal tissue
article
buccal mucosa
controlled study
dose time effect relation
drug dosage form
drug formulation
emulgel
experimental study
freeze thawing
gel
gingivitis
mucoadhesion
nanoemulsion
nonhuman
periodontitis
physical chemistry
LA - English
PY - 2015
SN - ["0975-6221", "2229-3590"]
SP - 18-27
ST - Role of propolis in augmenting the buccal mucoadhesion-an experiment based
report
T2 - Hygeia
TI - Role of propolis in augmenting the buccal mucoadhesion-an experiment based
report
VL - 7
ID - 13771
ER -
TY - JOUR
AB - Introduction: The etiological factors of periodontal diseases are the
habitation of dysbiotic bacteria, absence of beneficial bacteria, and
susceptibility of the host. Irresolute pattern in the periodontal diseases
pathogenesis leads to the evolution of novel antimicrobial therapy. Objective: The
objective of the study is to assess and compare the competency of locally delivered
probiotic paste with chlorhexidine gel as a supplement to scaling and root planing
(SRP) in chronic periodontitis patients. Materials and Methods: A split-mouth
randomized controlled trial was designed on 10 systemically healthy participants
having chronic periodontitis at three distinct quadrants with 5-6-mm pocket depth.
The sites in each participant were randomly selected for Group A (negative
control), Group B (positive control), and Group C (test). In Group A, only SRP,
Group B - SRP + chlorhexidine local drug delivery (LDD), Group C - SRP + probiotic
LDD were done, respectively. Gingival index (GI) and bleeding index (BI) were
determined at baseline, 3 rd, 6 th, and 9 th weeks, whereas probing pocket depth
(PPD), Russell's periodontal index, and clinical attachment level were checked at
baseline and after 9 weeks. Results: It shows a significant reduction in GI, BI,
PPD, and gain of CAL in probiotic LDD group. Conclusion: Nowadays, since microbes
are rapidly developing resistance to antibiotics, the development of probiotics is
a boon for the treatment of periodontal diseases. Diseases of the periodontium are
not restricted to the oral cavity alone but also have strong systemic effects.
Hence, probiotics give a natural and promising choice of therapy to establish both
good oral and systemic health.
AN - rayyan-563559862
AU - Vishnusripriya, J.
AU - Melath, A.
AU - Feroz, M.
AU - Subair, K.
AU - Chandran, N.
DO - 10.4103/jisp.jisp-704-20
IS - 3
KW - ultraviolet spectrophotometer
viscometer
cellophane
chlorhexidine
glycerol
probiotic agent
sporlac
adult
article
clinical article
clinical trial
controlled study
dental scaling
drug release
female
gingiva bleeding
gingival index
human
in vitro study
index finger
Lactobacillus
Lactobacillus sporogenes
light absorption
male
nonhuman
periodontal index
root planing
thumb
LA - English
PY - 2022
SN - ["0975-1580", "0972-124X"]
SP - 262-268
ST - Comparative evaluation of locally delivered probiotic paste and chlorhexidine
gel as an adjunct to scaling and root planing in treating chronic periodontitis: A
split-mouth randomized clinical trial
TI - Comparative evaluation of locally delivered probiotic paste and chlorhexidine
gel as an adjunct to scaling and root planing in treating chronic periodontitis: A
split-mouth randomized clinical trial
VL - 26
ID - 13236
ER -
TY - JOUR
AB - Aim To assess the presence of Enterococcus faecalis after root canal
treatment in single or multiple visits in an ex vivo model. Methodology Forty-five
premolar teeth were infected ex vivo with E. faecalis for 60 days. The canals were
then prepared using a crowndown technique with System GT and Gates-Glidden burs and
irrigated with 2% chlorhexidine gel. The specimens were divided into five groups
(G1, G2, G3, G4 and G5) according to the time elapsed between chemical-mechanical
preparation and root canal filling, the irrigant solution used and the use or
nonuse of a calcium hydroxide intra-canal medicament. The teeth were then root-
filled and incubated for 60 days at 37 degrees C. Dentine chips were removed from
the canal walls with sequential sterile round burs at low speed. The samples
obtained with each bur were immediately collected in separate test tubes containing
Brain-Heart Infusion broth. These samples were placed onto agar plates and colony
forming units were counted after 24 h at 37 degrees C. Data were ranked and
analysed using the Kruskal-Wallis statistical test. Results Enterococcus faecalis
was recovered from 20% (three of 15 specimens) of G1 (chlorhexidine irrigation and
immediate root filling in a single visit), 25% (four of 15 specimens) of G2
(chlorhexidine irrigation and filling after 14 days use of a calcium hydroxide
dressing in multiple visits), 40% (two of five specimens) of G3 (chlorhexidine
irrigation and filling after 7 days), 60% (three of five specimens) of G4 (saline
irrigation and filling after 7 days) and from 100% (five of five specimens) of G5
(saline irrigation and immediate filling without sealer). Conclusions Neither
single- nor multiple-visit root canal treatment ex vivo, eliminated E. faecalis
completely from dentinal tubules. Up to 60 days after root filling, E. faecalis
remained viable inside dentinal tubules. When no sealer was used, E. faecalis
presented a higher growth rate.
AN - rayyan-563562617
AU - Vivacqua-Gomes, N.
AU - Gurgel, E. D.
AU - Gomes, Bpfa
AU - Zaia, A. A.
AU - Souza, F. J.
DO - 10.1111/j.1365-2591.2005.00992.x
IS - 10
PY - 2005
SN - ["0143-2885", "1365-2591"]
SP - 697-704
ST - Recovery of Enterococcus faecalis after single- or multiple-visit root canal
treatments carried out in infected teeth ex vivo
TI - Recovery of Enterococcus faecalis after single- or multiple-visit root canal
treatments carried out in infected teeth ex vivo
VL - 38
Y2 - 10
ID - 15991
ER -
TY - JOUR
AB - Background: Biological complications around implants are mainly due to
microbial biofilm which induces inflammatory reactions in periimplant soft tissues
and bone. These reactions are defined as “periimplant diseases” and are
specifically termed as peri-implant mucositis and peri-implantitis. As a first
approach for their treatment, non- surgical interventions should be attempted prior
to any surgical procedure. The main goal of non-surgical treatment is to control
infection as early as possible, and maintain stable and healthy clinical conditions
or improve them before surgical intervention. Description of the procedure: In this
report, non-surgical approach for treatment of peri-implant mucositis and peri-
implantitis in 4 clinical cases will be presented. All of the patients were women
above the age of 60 and were in maintenance phase of periodontal treatment. (a)
Sessions of laser irradiation using 980 nm diode laser and/or sessions of
photothermal therapy with 810 nm diode laser and infracyanine green (as
photosensitizer), (b) supragingival and subgingival air-polishing with erythritol,
and (c) local application of minocycline gel and/or oral antiseptic gel were
performed. In cases of severe peri-implantitis, implants were extracted. Two to
four year follow-up results are presented. Outcomes: Regarding implants with
mucositis, non-surgical approach improved clinical signs of inflammation, and even
in some cases resulted in complete resolution of inflammation (absence of
suppuration and bleeding on probing). For implants with early peri-implantitis,
non-surgical intervention resulted in complete resolution of inflammation and
increase in bone level (radiographic finding). With regards to implants with
moderate to severe peri-implantitis, clinical signs and in some cases radiographic
bone level increased; nevertheless surgical intervention is still required.
Conclusions: Non-surgical management of peri-implant mucositis and peri-implantitis
could potentially improve condition of peri-implant tissues and bone and prepare
them for surgical intervention. In cases of peri-implant mucositis and early peri-
implantitis, complete resolution of inflammation and radiographic bone level
improvement can be observed. However, the outcome cannot always be predicted.
AN - rayyan-563559844
AU - Vlachos, M.
AU - Fourmousis, I.
AU - Marinis, K.
DO - 10.1111/jcpe.13637
erythritol
minocycline
adult
adverse device effect
bleeding on probing
bone level
case report
clinical article
conference abstract
diode laser
drug therapy
female
follow up
human
inflammation
periimplantitis
periodontium
suppuration
surgery
LA - English
PY - 2022
SN - 1600-051X
SP - 379-380
ST - Non-surgical management of peri-implant diseases: 4 clinical cases
TI - Non-surgical management of peri-implant diseases: 4 clinical cases
VL - 49
ID - 13218
ER -
TY - JOUR
AB - While periodontal (PD) disease is among principal causes of tooth loss
worldwide, regulation of concomitant soft and mineralized PD tissues, and PD
pathogenesis have not been completely clarified yet. Besides, relevant pre-clinical
models and in vitro platforms have limitations in simulating human physiology.
Here, we have harnessed three-dimensional bioprinting (3DBP) technology for
developing a multi-cellular microtissue model resembling PD ligament-alveolar bone
(PDL-AB) biointerface for the first time. 3DBP parameters were optimized; the
physical, chemical, rheological, mechanical, and thermal properties of the
constructs were assessed. Constructs containing gelatin methacryloyl (Gel-MA) and
hydroxyapatite-magnetic iron oxide nanoparticles showed higher level of compressive
strength when compared with that of Gel-MA constructs. Bioprinted self-supporting
microtissue was cultured under flow in a microfluidic platform for >10 days without
significant loss of shape fidelity. Confocal microscopy analysis indicated that
encapsulated cells were homogenously distributed inside the matrix and preserved
their viability for >7 days under microfluidic conditions. Immunofluorescence
analysis showed the cohesion of stromal cell surface marker-1+ human PDL
fibroblasts containing PDL layer with the osteocalcin+ human osteoblasts containing
mineralized layer in time, demonstrating some permeability of the printed
constructs to cell migration. Preliminary tetracycline interaction study indicated
the uptake of model drug by the cells inside the 3D-microtissue. Also, the non-
toxic levels of tetracycline were determined for the encapsulated cells. Thus, the
effects of tetracyclines on PDL-AB have clinical significance for treating PD
diseases. This 3D-bioprinted multi-cellular periodontal/osteoblastic microtissue
model has potential as an in vitro platform for studying processes of the human
PDL.
AN - rayyan-563559823
AU - Vurat, M. T.
AU - Şeker
AU - Lalegül-Ülker, Ö
AU - Parmaksiz, M.
AU - Elçin, A. E.
AU - Elçin, Y. M.
DO - 10.1016/j.gendis.2020.11.011
IS - 4
KW - lab on a chip
hydroxyapatite
magnetic iron oxide nanoparticle
osteocalcin
tetracycline
alveolar bone
article
cell encapsulation
cell viability
confocal microscopy
controlled study
fibroblast
flow kinetics
histocompatibility
human
human tissue
immunofluorescence
in vitro study
osteoblast
periodontal disease
resazurin assay
stroma cell
synthesis
thermogravimetry
tissue engineering
LA - English
PY - 2022
SN - ["2352-3042", "2352-4820"]
SP - 1008-1023
ST - Development of a multicellular 3D-bioprinted microtissue model of human
periodontal ligament-alveolar bone biointerface: Towards a pre-clinical model of
periodontal diseases and personalized periodontal tissue engineering
T2 - Genes Dis.
TI - Development of a multicellular 3D-bioprinted microtissue model of human
periodontal ligament-alveolar bone biointerface: Towards a pre-clinical model of
periodontal diseases and personalized periodontal tissue engineering
VL - 9
ID - 13197
ER -
TY - JOUR
AB - Advances in the understanding of the aetiology, epidemiology, pathogenesis
and microbiology of periodontal pocket flora have revolutionized the strategies for
the management of intraperiodontal pocket diseases. Intra-pocket, sustained
release, drug delivery devices have been shown to be clinically effective in the
treatment of periodontal infections. Several degradable and non-degradable devices
are under investigation for the delivery of antimicrobial agents into the
periodontal pocket including non-biodegradable fibres, films (biodegradable and
non-biodegradable), bio-absorbable dental materials, biodegradable gels/ointments,
injectables and microcapsules. With the realization that pocket bacteria accumulate
as biofilms, studies are now being directed towards eliminating/killing biofilm
concentrations rather than their planktonic (fluid phase) counterparts.
Intraperiodontal pocket drug delivery has emerged as a novel paradigm for the
future research. Similarly, bioadhesive delivery systems are explored that could
significantly improve oral therapeutics for periodontal disease and mucosal
lesions. A strategy is to target a wide range of molecular mediators of tissue
destruction and hence arrest periodontal disease progression. Research into
regenerating periodontal structures lost as a result of disease has also shown
substantial progress in the last 25 years.
AN - rayyan-563560989
AU - Vyas, S. P.
AU - Sihorkar, V.
AU - Mishra, V.
DO - 10.1046/j.1365-2710.2000.00261.x
IS - 1
KW - adhesive agent
amoxicillin
antibiotic agent
antiinfective agent
antimetabolite
azanidazole
chitosan
chlorhexidine
clavulanic acid
clindamycin
concanavalin A
minocycline
doxycycline
elysol
erythromycin
fluoride
flurbiprofen
imidazole
ketoprofen
metronidazole
naproxen
niridazole
onsite
penicillin G
spiramycin
tetracycline
tinidazole
unclassified drug
bacterial infection
biodegradation
biofilm
clinical trial
gel
gingivitis
human
immune response
microbiology
microcapsule
mouth hygiene
nonhuman
ointment
pathogenesis
periodontal disease
review
tooth plaque
actisite
dentomycin
elyzol
perio chip
LA - English
PY - 2000
SN - 0269-4727
SP - 21-42
ST - Controlled and targeted drug delivery strategies towards intraperiodontal
pocket diseases
T2 - J. Clin. Pharm. Ther.
TI - Controlled and targeted drug delivery strategies towards intraperiodontal
pocket diseases
VL - 25
ID - 14363
ER -
TY - JOUR
AN - rayyan-563561637
AU - Wacharanad, S.
AU - Thatree, P.
AU - Yiemwattana, P.
AU - Paoprajak, P.
AU - Ngamsangiam, P.
AU - Valyanont, M.
AU - Yiemwattana, I.
DO - 10.1055/s-0041-1725574
IS - 3
PY - 2021
SP - 574-578
ST - Antimicrobial Activity of Roselle-capped Silver Nanochip on Aggregatibacter
T2 - European Journal of Dentistry
TI - Antimicrobial Activity of Roselle-capped Silver Nanochip on Aggregatibacter
85107292176&doi=10.1055%2fs-0041-
1725574&partnerID=40&md5=9389a816ea36795656708c1dcbca68cb
VL - 15
ID - 15011
ER -
TY - JOUR
AB - OBJECTIVES: This article aimed to study the effects of the roselle-capped
silver nanochip (SNP-Ro chip) against Aggregatibacter actinomycetemcomitans, and
the toxicity of this film on fibroblast cells to develop this SNP-Ro chip into a
local chemical for the treatment of periodontitis in the future. MATERIALS AND
METHODS: Using a microwave-assisted synthesis method, silver nanoparticles (SNPs)
were prepared from a silver nitrate solution and roselle extract as a reducing and
capping agent. Then, SNP-Ro chips were fabricated by mixing a solution of SNP-Ro
with alginate gel. The antimicrobial effect of the synthesized SNP-Ro chips was
performed by the disc diffusion technique and time kill assay. The cytotoxic effect
was also determined by the MTS assay. STATISTICAL ANALYSIS: One-way analysis of
variance (ANOVA) and Scheffe's method were used to analyze the data for this
experiment. RESULTS: All three ratios of the SNP-Ro chip produced inhibition
zones ranging between 18.75 ± 2.08 and 19.03 ± 2.25 mm. In studying the killing
time, the three groups of the SNP-Ro chips completely eradicated A.
actinomycetemcomitans within 180 minutes. The percentage of the viable SNP-Ro chip-
treated human gingival fibroblasts (HGFs) were significantly increased when
compared with the alginate chip-treated cells (p < 0.05). CONCLUSION: This study
developed a new method for the deposition of SNPs in alginate gel to make a thin
small chip for the sustained release of the SNPs in a periodontal lesion.
Therefore, the SNP-Ro chip has the potential to be developed as an adjunctive
locally delivered antimicrobial agent in periodontal therapy.
AN - rayyan-563561230
AU - Wacharanad, S.
AU - Thatree, P.
AU - Yiemwattana, P.
AU - Paoprajak, P.
AU - Ngamsangiam, P.
AU - Valyanont, M.
AU - Yiemwattana, I.
DO - 10.1055/s-0041-1725574
IS - 3
J2 - Eur J Dent
LA - eng
N1 - Department of Preventive Dentistry, Faculty of Dentistry, Naresuan
University, Phitsanulok, Thailand.; Secondary Demonstration School, Naresuan
University, Phitsanulok, Thailand.; Secondary Demonstration School, Naresuan
University, Phitsanulok, Thailand.; Faculty of Dentistry, Naresuan University,
Phitsanulok, Thailand.; Faculty of Dentistry, Naresuan University, Phitsanulok,
Thailand.; Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand.;
Department of Preventive Dentistry, Faculty of Dentistry, Naresuan University,
Phitsanulok, Thailand.
PY - 2021
SN - 1305-7456 (Print)
SP - 574-578
ST - Antimicrobial Activity of Roselle-capped Silver Nanochip on Aggregatibacter
T2 - European journal of dentistry
TI - Antimicrobial Activity of Roselle-capped Silver Nanochip on Aggregatibacter
VL - 15
Y2 - 7
ID - 14604
ER -
TY - JOUR
AB - Objectives: We sought to investigate the healing efficacy of thermosensitive
in situ gelling formulation containing metronidazole and diclofenac potassium on
ligature-induced periodontitis (LIP) in rats. Methods: We used 30 adult male
Sprague-Dawley rats; 24 rats were subjected to LIP, while the remaining six rats
were used as control. The 24 rats with LIP were subdivided into four groups of six
rats each. Group 1 received 5% metronidazole loaded gel, group 2 received 0.2%
diclofenac potassium loaded gel, group 3 received 5% metronidazole and 0.2%
diclofenac potassium, and group 4 (the control group) did not receive any
treatment. Treatment was administered on day 0, and the rats were monitored over
seven days. Specimens were collected for histological examination to assess the
healing process. Results: We found a statistically significant difference (p <
0.050) in the inflammatory and repair parameters of the healing process between
different treatments. Combining the two drugs significantly accelerated the healing
compared to the drugs given alone. Conclusions: Using a combination of diclofenac
and metronidazole could potentially accelerate the healing process compared to the
use of a single drug of either diclofenac or metronidazole.
AN - rayyan-563559857
AU - Wadi, N. M. A.
AU - Ahuja, A.
AU - Peh, K. K.
DO - 10.5001/omj.2022.66
IS - 3
KW - syringe
ketamine
metronidazole
xylazine
animal experiment
animal model
animal tissue
article
controlled study
drug combination
edema
histology
male
necrosis
nonhuman
periodontitis
rat
LA - English
PY - 2022
SN - ["2070-5204", "1999-768X"]
ST - Healing Enhancement Assessment of Thermosensitive in Situ Gelling Formulation
Containing Metronidazole and Diclofenac Potassium for Ligature-induced
Periodontitis in Rats
T2 - Oman Med. J.
TI - Healing Enhancement Assessment of Thermosensitive in Situ Gelling Formulation
Containing Metronidazole and Diclofenac Potassium for Ligature-induced
Periodontitis in Rats
VL - 37
ID - 13231
ER -
TY - JOUR
AB - The effects of topical copaiba oil extract and topical corticosteroid were
assessed on oral wound healing in an in vivo model using 96 male Wistar rats.
Traumatic ulcers were caused in the dorsum of the tongue using a 3-mm punch tool.
The animals were divided into: Control; Corticosteroid; Placebo and Copaiba oil
Group. The animals received two daily applications of the products. The control
group received only daily handling. Six rats in each group were euthanized at days
3, 5, 10 and 14. The animals were monitored daily to determine wound status. The
weigh was assessed at day 0 and euthanasia day. The percentage of repair was
calculated, and histopathological aspects were analyzed. The Kruskal-Wallis test
was used to compare the results between groups and times of evaluation. Closing
time was assessed through the log-rank test. The corticosteroid group lost more
weight at days 10 and 14 than the control group (p < 0.05). Moreover, the healing
time of corticosteroid group was longer than the control group (p = 0.007). No
differences were observed between the copaiba oil group and the control group. We
concluded that topical copaiba oil, in spite of being safe, did not accelerate the
process of oral wound healing. Copyright (C) 2017 John Wiley & Sons, Ltd.
AN - rayyan-563562642
AU - Wagner, V. P.
AU - Webber, L. P.
AU - Ortiz, L.
AU - Rados, P. V.
AU - Meurer, L.
AU - Lameira, O. A.
AU - Lima, R. R.
AU - Martins, M. D.
DO - 10.1002/ptr.5845
IS - 8
PY - 2017
SN - ["0951-418X", "1099-1573"]
SP - 1283-1288
ST - Effects of Copaiba Oil Topical Administration on Oral Wound Healing
T2 - PHYTOTHERAPY RESEARCH
TI - Effects of Copaiba Oil Topical Administration on Oral Wound Healing
VL - 31
Y2 - 8
ID - 16016
ER -
TY - JOUR
AB - Background: The purpose of this study was to determine the effects of
periodontal treatment with a sustained-release, biodegradable gel containing 8.5%
doxycycline on the anaerobic flora and on antibiotic susceptibility patterns
associated with subgingival plaque and saliva. Methods: Forty-five subjects with
adult periodontitis were entered into a parallel design, single-blind study of 6
months' duration. The subjects were randomized to receive either doxycycline
treatment (n = 23) or oral hygiene instruction/reinforcement (n = 22). Saliva and
subgingival plaque samples were collected prior to and at 7, 21, 91, and 182 days
after initiation of treatment. The proportion of the cultivable flora resistant to
10 μg doxycycline/ml was determined relative to total anaerobic counts, and the 3
most predominant colony types resistant to doxycycline were individually
enumerated. A representative of each was subcultured, identified to genus and
species level, and tested for its susceptibilities to 6 antibiotics. Results: A
significant decrease (P<0.01) in total anaerobic counts following doxycycline
treatment caused a transient increase in the proportion, but not in the actual
counts, of doxycycline-resistant bacteria recovered from both plaque and saliva at
7 and 21 days but not at 91 or 182 days. The same doxycycline-resistant taxa were
recovered at all sample periods including baseline. Regardless of treatment, the
isolates were similarly distributed and belonged to the same bacterial groups.
Conclusions: Doxycycline treatment significantly reduced the anaerobic population
in plaque but did not result in a change in either the number of resistant bacteria
present or the acquisition of antibiotic resistance.
AN - rayyan-563560988
AU - Walker, C. B.
AU - Godowski, K. C.
AU - Borden, L.
AU - Lennon, J.
AU - Nangó, S.
AU - Stone, C.
AU - Garrett, S.
DO - 10.1902/jop.2000.71.5.768
IS - 5
KW - doxycycline
adult
aged
anaerobic bacterium
article
bacterial count
bacterial flora
clinical article
clinical trial
controlled study
female
human
male
periodontitis
saliva
tooth plaque
LA - English
PY - 2000
SN - 0022-3492
SP - 768-774
ST - The effects of sustained release doxycycline on the anaerobic flora and
antibiotic-resistant patterns in subgingival plaque and saliva
TI - The effects of sustained release doxycycline on the anaerobic flora and
antibiotic-resistant patterns in subgingival plaque and saliva
VL - 71
ID - 14362
ER -
TY - JOUR
AB - Objective: The aim of this study was to analyse the antibacterial effects of
Emdogain (R) Get or its constituents on the growth of the suspected
periodontopathogen Porphyromonas gingivatis. Study design: The effects of the
proteins of enamel matrix derivative (EMD), the commercial product Emdogain (R) Gel
or its vehicle propylene glycol alginate (PGA) (Straumann, Switzerland) on P
gingivalis growth were determined by two methods: broth dilution assay (BDA) and
agar diffusion assay (ADA). Results: BDA-Emdogain (R) Gel inhibited moderately the
growth of P gingivalis, whereas EMD showed no effect. The PGA vehicle inhibited the
growth completely. ADA-Emdogain (R) Gel resulted in some inhibition in growth but
was not significantly different from control. EMD revealed no zone of inhibition.
PGA demonstrated statistically significant zones of inhibition. Conclusion:
Emdogain (R) Gel shows moderate antibacterial activities against P gingivalis.
These properties seem to be due to the PGA component of the get preparation. 2005
AN - rayyan-563562429
AU - Walter, C.
AU - Jawor, P.
AU - Hagewald, S.
DO - 10.1016/j.archoralbio.2005.07.005
IS - 3
PY - 2006
SN - ["0003-9969", "1879-1506"]
SP - 171-176
ST - Moderate effect of enamel matrix derivative (Emdogain (R) Gel) on
Porphyromonas gingivalis growth in vitro
TI - Moderate effect of enamel matrix derivative (Emdogain (R) Gel) on
Porphyromonas gingivalis growth in vitro
VL - 51
Y2 - 3
ID - 15803
ER -
TY - JOUR
AB - In periodontal treatment, topical adjunctive therapy with antimicrobials or
anti-inflammatory agents is frequently applied. However, currently available drug
carrier biomaterials often exhibit poor perfusion into small crevices, such as the
deep and irregular periodontal pockets, due to relatively high viscosity. Moreover,
high polymer concentrations of the polymer can potentially be cytotoxic upon
confined local administration. This study aimed to formulate an antimicrobial and
anti-inflammatory treatment option, by incorporating doxycycline (DOX) and/or
lipoxin A(4) (LXA(4)) into 0.5 wt% thermo-reversible polyisocyanopeptide (PIC). PIC
can form hydrogels upon low polymer concentration, and we hypothesized that the
thermo-reversible nature of the material would allow for application into the
periodontal pocket. The formulations were characterized in vitro and finally tested
in dogs with naturally occurring periodontitis, which were not euthanized
afterward. Results showed that PIC/DOX/LXA(4) hydrogel could be easily prepared and
injected into periodontal pockets. The PIC hydrogel facilitated the release of DOX
or LXA(4) for around 4 days in vitro. When applied in dogs, the hydrogel exerted no
local or systemic adverse effects. Gels loaded with LXA(4) and/or DOX reduced the
subgingival bacterial load and pro-inflammatory interleukin-8 level. In addition,
PIC-DOX and PIC-DOX+LXA(4) improved gingival clinical attachment by 0.6 mm compared
with conventional periodontal treatment alone (i.e. mechanical debridement). In
conclusion, the thermo-reversible PIC hydrogel is a safe and effective vehicle for
periodontal drug delivery. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd.
AN - rayyan-563562009
AU - Wang, B.
AU - Booij-Vrieling, H. E.
AU - Bronkhorst, E. M.
AU - Shao, J. L.
AU - Kouwer, P. H. J.
AU - Jansen, J. A.
AU - Walboomers, X. F.
AU - Yang, F.
DO - 10.1016/j.actbio.2020.09.018
PY - 2020
SN - ["1742-7061", "1878-7568"]
SP - 259-267
ST - Antimicrobial and anti-inflammatory thermo-reversible hydrogel for
periodontal delivery
TI - Antimicrobial and anti-inflammatory thermo-reversible hydrogel for
VL - 116
Y2 - 10 y3 - 15
ID - 15383
ER -
TY - JOUR
AB - In periodontal treatment, topical adjunctive therapy with antimicrobials or
anti-inflammatory agents is frequently applied. However, currently available drug
carrier biomaterials often exhibit poor perfusion into small crevices, such as the
deep and irregular periodontal pockets, due to relatively high viscosity. Moreover,
high polymer concentrations of the polymer can potentially be cytotoxic upon
confined local administration. This study aimed to formulate an antimicrobial and
anti-inflammatory treatment option, by incorporating doxycycline (DOX) and/or
lipoxin A4 (LXA4) into 0.5 wt% thermo-reversible polyisocyanopeptide (PIC). PIC can
form hydrogels upon low polymer concentration, and we hypothesized that the thermo-
reversible nature of the material would allow for application into the periodontal
pocket. The formulations were characterized in vitro and finally tested in dogs
with naturally occurring periodontitis, which were not euthanized afterward.
Results showed that PIC/DOX/LXA4 hydrogel could be easily prepared and injected
into periodontal pockets. The PIC hydrogel facilitated the release of DOX or LXA4
for around 4 days in vitro. When applied in dogs, the hydrogel exerted no local or
systemic adverse effects. Gels loaded with LXA4 and/or DOX reduced the subgingival
bacterial load and pro-inflammatory interleukin-8 level. In addition, PIC-DOX and
PIC-DOX+LXA4 improved gingival clinical attachment by 0.6 mm compared with
conventional periodontal treatment alone (i.e. mechanical debridement). In
conclusion, the thermo-reversible PIC hydrogel is a safe and effective vehicle for
periodontal drug delivery.
AN - rayyan-563560080
AU - Wang, B.
AU - Booij-Vrieling, H. E.
AU - Shao, J.
AU - Jansen, J. A.
AU - Yang, F.
DO - 10.1016/j.actbio.2020.09.018
hydrogel
interleukin 10
interleukin 6
interleukin 8
lipoxin A
polymer
animal tissue
article
bacterial load
beagle
controlled study
drug formulation
drug release
in vitro study
incisor
microflora
molar tooth
nonhuman
periodontal pocket
physical chemistry
premolar tooth
priority journal
LA - English
PY - 2020
SN - ["1878-7568", "1742-7061"]
SP - 259-267
ST - Antimicrobial and anti-inflammatory thermo-reversible hydrogel for
T2 - Acta Biomater.
TI - Antimicrobial and anti-inflammatory thermo-reversible hydrogel for
VL - 116
ID - 13454
ER -
TY - JOUR
AB - In periodontal treatment, patient differences in disease phenotype and
treatment responses are well documented. Therefore, therapy duration and dosage
should be tailored to the requirements of individual patients. To facilitate such
personalized medication, a tunable and controllable system is needed to deliver
drugs directly into the diseased periodontal pockets. The current study established
a system to achieve different drug release rates and periods by incorporating
bioactive agents into poly(lactic-co-glycolic acid) (PLGA) microspheres dispersed
into a novel thermo-reversible polyisocyanopeptide (PIC) hydrogel. Specifically,
two drugs, i.e. doxycycline and lipoxin, were separately loaded into acid-
terminated and ester-capped PLGA by electrospraying. Different formulations were
developed by loading the two kinds of PLGA microspheres with different mass ratios
in the PIC gels. The results demonstrated that the PIC-PLGA vehicle exhibited
appropriate injectability, long-term structural stability, and no obvious in vivo
inflammatory response for the desired clinical application. Furthermore, the
release profiles of drugs could be manipulated by adjusting the loaded mass ratio
of acid- and ester- terminated PLGA microspheres in the PIC gels. The more ester-
capped PLGA was used, the slower the release rate and the longer the release
period, and vice versa. Additionally, the released drugs still preserved their bio-
efficacy. This PIC-PLGA system can be further developed and tested in translational
studies to demonstrate the final clinical benefit.
AN - rayyan-563560108
AU - Wang, B.
AU - Wang, J.
AU - Shao, J.
AU - Jansen, J. A.
AU - Yang, F.
DO - 10.1016/j.jconrel.2020.05.004
KW - doxycycline
hydrogel
interleukin 10
interleukin 1alpha
interleukin 1beta
interleukin 6
lipoxin A
polyglactin
polyisocyanopeptide hydrogel
unclassified drug
animal experiment
animal model
animal tissue
article
cell density
comparative study
controlled study
drug degradation
drug efficacy
drug formulation
drug release
electric conductivity
electrospray
in vitro study
male
molecular weight
nonhuman
particle size
periodontal disease
periodontal pocket
personalized medicine
phagocytosis
phenotype
priority journal
rat
RAW 264.7 cell line
treatment duration
treatment response
LA - English
PY - 2020
SN - ["1873-4995", "0168-3659"]
SP - 134-145
ST - A tunable and injectable local drug delivery system for personalized
periodontal application
TI - A tunable and injectable local drug delivery system for personalized
periodontal application
VL - 324
ID - 13482
ER -
TY - JOUR
AB - This study evaluated the clinical efficacy of 2% chlorhexidine (CHX) gel on
intracanal bacteria reduction during root canal instrumentation. The additional
antibacterial effect of an intracanal dressing (Ca[OH]2 mixed with 2% CHX gel) was
also assessed. Forty-three patients with apical periodontitis were recruited. Four
patients with irreversible pulpitis were included as negative controls. Teeth were
instrumented using rotary instruments and 2% CHX gel as the disinfectant. Bacterial
samples were taken upon access (S1), after instrumentation (S2), and after 2 weeks
of intracanal dressing (S3). Anaerobic culture was performed. Four samples showed
no bacteria growth at S1, which were excluded from further analysis. Of the samples
cultured positively at S1, 10.3% (4/39) and 8.3% (4/36) sampled bacteria at S2 and
S3, respectively. A significant difference in the percentage of positive culture
between S1 and S2 (p < 0.001) but not between S2 and S3 (p = 0.692) was found.
These results suggest that 2% CHX gel is an effective root canal disinfectant and
additional intracanal dressing did not significantly improve the bacteria reduction
on the sampled root canals. © 2007 American Association of Endodontists.
AN - rayyan-563560734
AU - Wang, C. S.
AU - Arnold, R. R.
AU - Trope, M.
AU - Teixeira, F. B.
DO - 10.1016/j.joen.2007.07.010
IS - 11
calcium hydroxide
chlorhexidine
anaerobic bacterium
article
bacterial count
drug combination
drug effect
evaluation study
gel
human
microbiology
tooth pulp
LA - English
PY - 2007
SN - 0099-2399
SP - 1283-1289
ST - Clinical Efficiency of 2% Chlorhexidine Gel in Reducing Intracanal Bacteria
T2 - J. Endod.
TI - Clinical Efficiency of 2% Chlorhexidine Gel in Reducing Intracanal Bacteria
VL - 33
ID - 14108
ER -
TY - JOUR
AB - Periodontitis is a long-term inflammatory illness and a leading contributor
to tooth loss in humans. Due to the influence of the anatomic parameters of teeth,
such as root bifurcation lesions and the depth of the periodontal pocket, basic
periodontal treatment on its own often does not completely obliterate flora
microorganisms. As a consequence, topical medication has become a significant
supplement in the treatment of chronic periodontitis. Berberine (BBR) has various
pharmacological effects, such as hypoglycemic, antitumor, antiarrhythmic, anti-
inflammatory, etc. The target of our project is to develop a safe and non-toxic
carrier that can effectively release berberine, which can significantly reduce
periodontal tissue inflammation, and to investigate whether berberine
thermosensitive hydrogel can exert anti-inflammatory and osteogenic effects by
modulating phosphatifylinositol-3-kinase/Protein Kinase B (PI3K/AKT) signaling
pathway. Consequently, firstly berberine temperature-sensitive hydrogel was
prepared, and its characterizations showed that the mixed solution gelated within 3
min under 37 °C with a hole diameter of 10–130 µm, and the accumulation of
berberine release amounted to 89.99% at 21 days. CCK-8 and live-dead cell staining
results indicated that this hydrogel was not biotoxic, and it is also presumed that
the optimum concentration of berberine is 5 µM, which was selected for subsequent
experiments. Real-time polymerase chain reaction (qRT-PCR) and Western blotting
(WB)results demonstrated that inflammatory factors, as well as protein levels, were
significantly reduced in the berberine-loaded hydrogel group, and LY294002 (PI3K
inhibitor) could enhance this effect (p < 0.05). In the berberine-loaded hydrogel
group, osteogenesis-related factor levels and protein profiles were visibly
increased, along with an increase in alkaline phosphatase expression, which was
inhibited by LY294002 (p < 0.05). Therefore, berberine thermosensitive hydrogel may
be an effective treatment for periodontitis, and it may exert anti-inflammatory and
osteogenic effects through the PI3K/AKT signaling pathway.
AN - rayyan-563559726
AU - Wang, C.
AU - Liu, C.
AU - Liang, C.
AU - Qu, X.
AU - Zou, X.
AU - Du, S.
AU - Zhang, Q.
AU - Wang, L.
DO - 10.3390/ijms24076364
IS - 7
berberine
beta actin
hydrogel
interleukin 1beta
interleukin 6
messenger RNA
protein kinase B
animal cell
article
bone development
controlled study
cytotoxicity assay
drug release
heat sensitivity
human
in vitro study
MC3T3-E1 cell line
nonhuman
periodontitis
protein expression
protein fingerprinting
RAW 264.7 cell line
signal transduction
Western blotting
LA - English
PY - 2023
SN - ["1422-0067", "1661-6596"]
ST - Role of Berberine Thermosensitive Hydrogel in Periodontitis via PI3K/AKT
Pathway In Vitro
TI - Role of Berberine Thermosensitive Hydrogel in Periodontitis via PI3K/AKT
Pathway In Vitro
VL - 24
ID - 13100
ER -
TY - JOUR
AB - Tissue engineering (TE) is critical in oral and craniofacial reconstruction.
One of the most popular topics on the biomaterial-based tissue regeneration process
may be the interaction between cells and scaffolds. An increasing number of studies
have identified the variables affecting cell–scaffold interaction. The creation and
investigation of new scaffolds for TE and regenerative medicine based on specific
interactions have become possible owing to these findings. This review discusses
the effects of various types of scaffold materials on cells in TE. Because the
intrinsic properties of scaffolds are essential, the influence of the physical,
chemical, mechanical, and biological characteristics of scaffold materials on cell–
scaffold interaction that has been discovered in recent research is elaborated in
this review. The components carried by scaffolds, the degradation process, and the
role of degraded products in cell–scaffold interactions are examined. Further, the
roles of cells, including cell types, functions, and adhesion mechanisms, and
extracellular matrix are discussed. Finally, the latest research progress on cell–
scaffold interactions among various engineered tissues or organs in the oral and
craniofacial region is summarized. A deeper understanding of cell–scaffold
interactions is anticipated to benefit the development of TE and regenerative
medicine.
AN - rayyan-563559716
AU - Wang, F.
AU - Cai, X.
AU - Shen, Y.
AU - Meng, L.
DO - 10.1016/j.bioactmat.2022.10.029
alginic acid
biomaterial
carbon nanotube
CD56 antigen
chitosan
dextran
elastin
fibrin
fibronectin
gamma interferon
genipin
gold nanoparticle
graphene
graphene oxide
hyaluronic acid
hydrogel
laminin
molecular scaffold
nanocomposite
nanofiller
osteocalcin
polymer
polysaccharide
sialoprotein
vascular endothelial cadherin
vasculotropin
adipogenesis
allotransplantation
angiogenesis
animal model
apoptosis
article
autophagy (cellular)
biocompatibility
biodegradability
biodegradation
biotransformation
bone defect
bone development
bone mineralization
bone tissue
cell adhesion
cell culture
cell migration
cell proliferation
cell viability
craniofacial surgery
electrostimulation
fibroblast
head and neck cancer
human
hydrophobicity
immune response
MAPK signaling
microenvironment
molecular weight
nonhuman
Notch signaling
odontoblast
osseointegration
osteoblast
osteoclastogenesis
oxidative stress
particle size
phagocytosis
phenotype
Pi3K/Akt signaling
plasticity
pluripotent stem cell
porosity
rat
signal transduction
somatic cell
stoichiometry
T lymphocyte
tissue engineering
tooth pulp
wettability
xerostomia
Young modulus
LA - English
PY - 2023
SN - 2452-199X
SP - 16-44
ST - Cell–scaffold interactions in tissue engineering for oral and craniofacial
reconstruction
T2 - Bioact. Mater.
TI - Cell–scaffold interactions in tissue engineering for oral and craniofacial
reconstruction
VL - 23
ID - 13090
ER -
TY - JOUR
AB - Egg yolk immunoglobulin (IgY) and LL37, potent antibacterial substances, can
fight against periodontitis. This work aimed to develop a locally injectable
hydrogel for potential co-delivery of special IgY and LL37-loaded solid lipid
nanoparticles (LL37-SLNs) to synergistically inhibit the proliferation of oral
pathogens, thus relieving periodontal inflammation and redness. The formulation of
thermosensitive hydrogel loaded with IgY and LL37-SLNs was developed by adopting
the Quality by Design approach. Then the formulations were optimized by two-factor
three-level full factorial design by Design-Expert software. Finally, the optimized
formulation was characterized and estimated in vitro and in vivo. In vitro release
and antibacterial activity studies have revealed that the optimized formulation was
homogeneous and can be released slowly, with sustainably antibacterial power. And
the physical and chemical composition analysis and morphological observations
further confirmed the sustained-release capability. On the other hand, in vivo
studies proved that the optimized formulation significantly decreased gingival
redness, bleeding, and plaque formation, avoided excessive resorption of alveolar
bone, and reduced the levels of inflammatory factor in periodontitis rats. In
conclusion, the optimized thermosensitive hydrogel loaded with IgY and LL37-SLNs
may be a promising local sustained-release preparation for the effective treatment
AN - rayyan-563559705
AU - Wang, F.
AU - Li, Z.
AU - Gan, X. Y.
AU - Lu, X. L.
AU - Jiao, B. H.
AU - Shen, M. H.
DO - 10.1016/j.ejps.2023.106444
KW - hydrogel
immunoglobulin Y
interleukin 6
poloxamer
ropocamptide
alveolar bone
animal experiment
animal model
animal tissue
article
comparative study
connective tissue
content uniformity
controlled study
cross linking
effective concentration
experimental design
factorial design
heat sensitivity
hydrogen bond
in vitro study
in vivo study
kinetics
male
nonhuman
product quality
quality by design
radiography
rat
retention time
risk assessment
sol-gel
tissue section
X ray
LA - English
PY - 2023
SN - ["1879-0720", "0928-0987"]
ST - Quality by design driven development and evaluation of thermosensitive
hydrogel loaded with IgY and LL37-SLNs to combat experimental periodontitis
TI - Quality by design driven development and evaluation of thermosensitive
hydrogel loaded with IgY and LL37-SLNs to combat experimental periodontitis
VL - 185
ID - 13079
ER -
TY - JOUR
AB - Purpose: To investigate the protective effect of bisleuconothine A on
periodontal tissue in rats and the mechanism involved. Methods: Adult male Sprague
Dawley rats (n = 32) weighing 180 - 200 g (mean weight, 190 ± 10 g) were randomly
assigned to four groups of eight rats each: control group, periodontitis group,
bisleuconothine A (50 mg/kg) group and bisleuconothine A (100 mg/kg) group. Rats in
the treatment groups received bisleuconothine intraperitoneally for two weeks.
Periodontitis was induced in the rats using standard procedures. Serum and tissue
samples were used for biochemical analysis. Alveolar bone loss was measured in rat
maxillae, while the activity of bone alkaline phosphatase (BALP) was determined in
serum. Tumor necrosis factor α (TNF-α) interleukin-1β and interleukin-6 (IL-1β and
IL-6) were determined in gingival tissue using enzyme-linked immunosorbent assay
(ELISA) kit. Gene and protein expressions of receptor activator of nuclear factor
kappa-Β ligand (RANKL), osteoprotegerin (OPG), and matrix metallopeptidase-9 (MMP-
9) were measured in gingival tissue using real-time quantitative polymerase chain
reaction (qRT-PCR) and Western blotting, respectively. Results: Bisleuconothine A
treatment significantly and dose-dependently reduced alveolar bone loss, as well as
serum levels of TNF-α, IL-1β and IL-6, but increased BALP activity in periodontitis
rats (p < 0.05). It also significantly and dose-dependently reduced mRNA
expressions of RANKL and MMP-9, but significantly increased OPG mRNA expression (p
< 0.05). Similarly, treatment with bisleuconothine A significantly and dose-
dependently down-regulated RANKL, p-NF-kB, p-IkBα and iNOS proteins in gingival
tissue of periodontitis rats (p < 0.05). The results of histopathological
examination indicated that bisleuconothine A treatment significantly reversed
histological changes in periodontal tissues of periodontitis rats. It also
significantly reduced the degree of polymorphonuclear (PMN) cell infiltration in
periodontal tissue. Conclusion: The results obtained show that bisleuconothine A
protects periodontal tissue via the regulation of RANKL expression and infiltration
of inflammatory cells.
AN - rayyan-563560152
AU - Wang, F.
AU - Sun, P.
AU - Sun, Q.
DO - 10.4314/tjpr.v19i3.6
IS - 3
KW - alkaline phosphatase bone isoenzyme
alkaloid
bisleuconothine A
gelatinase B
interleukin 1beta
interleukin 6
osteoprotegerin
unclassified drug
alveolar bone loss
animal experiment
animal model
animal tissue
article
blood sampling
controlled study
gene expression
gingival tissue
histology
histopathology
inflammatory cell
nonhuman
periodontitis
polymorphonuclear cell
protein expression
rat
Western blotting
LA - English
PY - 2020
SN - ["1596-9827", "1596-5996"]
SP - 497-503
ST - Bisleuconothine A protects periodontal tissue via the regulation of RANKL
expression and infiltration of inflammatory cells
TI - Bisleuconothine A protects periodontal tissue via the regulation of RANKL
expression and infiltration of inflammatory cells
VL - 19
ID - 13526
ER -
TY - JOUR
AB - The multi-bacterial environment of the oral cavity makes it hard for
periodontal regeneration. As a class of antimicrobial peptide, beta defensin has
been found to show broad-spectrum antibacterial ability. In addition, connective
tissue growth factor (CTGF) is demonstrated to play a great role in multi-
physiological events such as angiogenesis, wound healing and, more importantly,
fibrogenesis. In this study, human ?? defensin 3 (hBD3) and CTGF were co-
transfected into bone marrow derived mesenchymal stem cells (BMSCs) for preparing
cell sheets. The transfection efficiency was detected through fluorescence of eGFP
and western blot assay. Our results showed that the hBD3 and CTGF proteins were
highly and stably expressed in the BMSCs after transfection. The results of RT-PCR
and induced differentiation indicated that hBD3 promoted osteogenic differentiation
of BMSCs, while CTGF significantly increased fibrogenic differentiation even in the
presence of hBD3. The BMSCs acquired stronger capacity in terms of promoting M2
polarization of RAW 264.7 macrophages fulfilled by the transfection and secretion
of hBD3 and CTGF. To further evaluate the periodontal remodeling performance of
cell sheets, a coralline hydroxyapatite (CHA)-chitosan based hydrogel-human tooth
system was designed to simulate the natural periodontal environment. The results
showed that dense extracellular matrix, oriented fiber arrangement, and abundant
collagen deposition appeared in the area of BMSCs sheets after subcutaneous
transplantation. Altogether, our data showed that the lentivirus transfected BMSCs
sheets had a promising application prospect for periodontal repair.
AN - rayyan-563562331
AU - Wang, L.
AU - Wei, X. B.
AU - Duan, C. M.
AU - Yang, J. J.
AU - Xiao, S. Z.
AU - Liu, H. F.
AU - Sun, J.
DO - 10.1016/j.msec.2022.112657
PY - 2022
SN - 2772-9508
ST - Bone marrow mesenchymal stem cell sheets with high expression of hBD3 and
CTGF promote periodontal regeneration
T2 - BIOMATERIALS ADVANCES
TI - Bone marrow mesenchymal stem cell sheets with high expression of hBD3 and
VL - 133
Y2 - 2
ID - 15705
ER -
TY - JOUR
AB - The multi-bacterial environment of the oral cavity makes it hard for
periodontal regeneration. As a class of antimicrobial peptide, beta defensin has
been found to show broad-spectrum antibacterial ability. In addition, connective
tissue growth factor (CTGF) is demonstrated to play a great role in multi-
physiological events such as angiogenesis, wound healing and, more importantly,
fibrogenesis. In this study, human β defensin 3 (hBD3) and CTGF were co-transfected
into bone marrow derived mesenchymal stem cells (BMSCs) for preparing cell sheets.
The transfection efficiency was detected through fluorescence of eGFP and western
blot assay. Our results showed that the hBD3 and CTGF proteins were highly and
stably expressed in the BMSCs after transfection. The results of RT-PCR and induced
differentiation indicated that hBD3 promoted osteogenic differentiation of BMSCs,
while CTGF significantly increased fibrogenic differentiation even in the presence
of hBD3. The BMSCs acquired stronger capacity in terms of promoting M2 polarization
of RAW 264.7 macrophages fulfilled by the transfection and secretion of hBD3 and
CTGF. To further evaluate the periodontal remodeling performance of cell sheets, a
coralline hydroxyapatite (CHA)-chitosan based hydrogel-human tooth system was
designed to simulate the natural periodontal environment. The results showed that
dense extracellular matrix, oriented fiber arrangement, and abundant collagen
deposition appeared in the area of BMSCs sheets after subcutaneous transplantation.
Altogether, our data showed that the lentivirus transfected BMSCs sheets had a
promising application prospect for periodontal repair.
AN - rayyan-563559904
AU - Wang, L.
AU - Wei, X.
AU - Duan, C.
AU - Yang, J.
AU - Xiao, S.
AU - Liu, H.
AU - Sun, J.
DO - 10.1016/j.msec.2022.112657
KW - article
controlled study
fluorescence
human
human cell
human tissue
Lentivirus
macrophage
nonhuman
periodontium
polarization
RAW 264.7 cell line
regeneration
transplantation
Western blotting
beta defensin 3
collagen
endogenous compound
hydrogel
hydroxyapatite
LA - English
PY - 2022
SN - 1873-0191
SP - 112657
ST - Bone marrow mesenchymal stem cell sheets with high expression of hBD3 and
TI - Bone marrow mesenchymal stem cell sheets with high expression of hBD3 and
ID - 13278
ER -
TY - JOUR
AB - Bone regeneration (osteointegration) is an essential principle to analyze the
accomplishment of implant treatment. This aim of current study was assessment of
the osteoinductive potential and analgesic properties of the gold nanoparticles (Au
NPs), which were fabricated utilizing Anogeissus latifolia (A. latifolia)
phytochemicals. Green fabricated Au NPs showed an exceptional stability in
different blood components like human serum albumin (2%), bovine serum albumin
(2%), cysteine (0.2 M) and histidine (0.2 M). The bio fabricated Au NPs were also
observed to be non-hazardous when tested for their blood compatibility and
cytocompatibility by using erythrocytes and periodontal fibroblasts respectively.
Au NPs showed greater cell viability percentage (138 +/- 27.4) on exposure to MG-63
cell lines in comparison with control group (96 +/- 3.7) confirming their
osteoinductive potential. Further, analgesic activity studies revealed that a
strong antinociperceptive activity was displayed by A. latifolia aqueous leaf
extract and the formed Au NPs. In this study, it was concluded that the
biocompatible, environmental friendly and stable Au NPs were utilized as an
efficient analgesic property for pain management and as bone inducing agent in
dental tissue implantation treatment in nursing care.
AN - rayyan-563562630
AU - Wang, M. Y.
AU - Wang, L. M.
DO - 10.1016/j.jddst.2020.101753
PY - 2020
SN - ["1773-2247", "2588-8943"]
ST - Plant polyphenols mediated synthesis of gold nanoparticles for pain
management in nursing care for dental tissue implantation applications
T2 - JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
TI - Plant polyphenols mediated synthesis of gold nanoparticles for pain
management in nursing care for dental tissue implantation applications
VL - 58
Y2 - 8
ID - 16004
ER -
TY - JOUR
AB - Ozone is currently being considered as a possible oral antiseptic agent
because it is strongly antimicrobial and does not induce microbial resistance.
Here, we examined the effects of ozone exposure on the production of collagen type-
1 and inflammatory cytokines in primary human gingival fibroblasts (HGFs) in vitro
using enzyme-linked immunosorbent assays. In this study, we demonstrated that ozone
ointment increased type 1 collagen production and hindered pro-inflammatory
cytokine secretion from primary HGFs in vitro. HGFs were isolated from a 65-year-
old patient who had undergone surgery due to chronic periodontitis. The cells were
exposed to media with or without 0.05, 0.5 and 5 ppm ozone ointment for 24 hours 2
min. No cytotoxic effect of the ozone ointment was observed up to the concentration
of 0.5 ppm, cell viability was attenuated at the dose of 5 ppm. When ozone ointment
was used at the non-cytotoxic concentration of 0.5 ppm, it significantly enhanced
type 1 collagen production by HGFs within for 24 hours. Secretion of the pro-
inflammatory cytokines interleukin (IL)-6 and IL-8 by HGFs treated with
lipopolysaccharide (LPS) decreased when ozone ointment was present in the medium.
These results suggest that the therapeutic effect of ozone ointment against
periodontal disease is partially due to modulation of the function of HGFs.
AN - rayyan-563562519
AU - Wang, P. L.
AU - Tachi, Y.
AU - Masuno, K.
AU - Okusa, N.
AU - Imamura, Y.
DO - 10.2485/jhtb.27.209
IS - 3
PY - 2018
SN - 1341-7649
SP - 209-212
ST - The Study of Ozone Ointment on Human Gingival Fibroblasts Cell Proliferation
Ability and Anti-Inflammatory
TI - The Study of Ozone Ointment on Human Gingival Fibroblasts Cell Proliferation
Ability and Anti-Inflammatory
VL - 27
ID - 15893
ER -
TY - JOUR
AB - Periodontal disease is the leading cause of tooth loss, which is also a high-
risk factor for other diseases including oral cancer and cardiovascular disease.
Periodontitis is one of the most common type of periodontal diseases. Interleukin-
1β (IL-1β) plays a key role in the pathogenesis of periodontitis. However, the
mechanism how IL-1β is produced during periodontitis is still unclear. In the
present study, we found that human β-defensin 2 (hBD2) enhances IL-1β production
through an LPS-primed human acute monocytic leukemia (THP-1) macrophage model.
Inhibition of P2X purinoceptor 7 (P2X7) reduced hBD2-enhanced IL-1β production.
Incubation of LPS-primed THP-1 macrophages with potassium chloride also suppressed
hBD2-enhanced IL-1β production. Silence of inflammasome adaptor Nod-like receptor
family pyrin domain containing 3 (NLRP3) led to reduced hBD2-enhanced IL-1β
production. Likewise, inhibition of caspase-1 also resulted in the decrease of IL-
1β. Moreover, an ethidium bromide uptake test indicated that hBD2-activated
caspase-1 mediated pyroptotic pore formation. Subsequent lactate dehydrogenase
detection and flow cytometric analysis indicated that hBD2 also induced pyroptosis.
In brief, these findings illustrated not only the mechanism of hBD2 in enhancing
the inflammatory response, but also provided novel therapeutic targets for
periodontitis.
AN - rayyan-563559913
AU - Wang, P.
AU - Li, G.
AU - Gao, L.
AU - Zhao, C.
DO - 10.32604/biocell.2022.016607
IS - 5
KW - beta defensin 2
cryopyrin
interleukin 10
interleukin 17
interleukin 18
interleukin 1beta
interleukin 1beta converting enzyme
interleukin 22
interleukin 6
purinergic P2X7 receptor
transforming growth factor alpha
article
controlled study
cytokine production
flow cytometry
human
human cell
incubation time
lactate dehydrogenase blood level
macrophage
pathogenesis
periodontal disease
protein expression
protein function
pyroptosis
THP-1 cell line
Western blotting
LA - English
PY - 2022
SN - ["1667-5746", "0327-9545"]
SP - 1197-1207
ST - Human β-defensin 2 enhances IL-1β production and pyroptosis through P2X7-
mediated NLRP3 expression in macrophages
T2 - Biocell
TI - Human β-defensin 2 enhances IL-1β production and pyroptosis through P2X7-
mediated NLRP3 expression in macrophages
VL - 46
ID - 13287
ER -
TY - JOUR
AB - Nanozymes are nanomaterials with enzyme-like characteristics, which catalyze
the conversion of enzyme substrates and follow enzymatic kinetics under
physiological conditions. As a new generation of artificial enzymes, nanozymes
provide alternative approaches for those upon enzymatic catalysis. Compared with
natural enzymes, nanozymes have the advantages of simple preparation, good
stability and low cost, which makes nanozymes promising for application in many
fields, such as antimicrobial infection treatment. Many studies have reported that
nanozymes are capable of killing a number of pathogenic bacteria with resistance,
fungi as well as viruses, and have shown great curative effects for diseases caused
by these pathogens. Herein, we summarize the application of nanozymes for
antibacterial, antiviral, and antifungal therapies and outline the issues needing
resolution in the future. This article is categorized under: Therapeutic Approaches
and Drug Discovery > Nanomedicine for Infectious Disease.
AN - rayyan-563559892
AU - Wang, Q.
AU - Jiang, J.
AU - Gao, L.
DO - 10.1002/wnan.1769
IS - 2
antifungal agent
antivirus agent
artificial enzyme
gold nanoparticle
hydrogel
nanomaterial
nanozyme
unclassified drug
antibiotic therapy
antifungal therapy
antiviral therapy
bacterial infection
burn
catalysis
cholecystitis
dental caries
diabetes mellitus
eczema
enteritis
enzyme activity
enzyme kinetics
enzyme substrate
gastritis
human
mouth ulcer
mycosis
myositis
nonhuman
periodontitis
peritonitis
physical chemistry
pneumonia
review
sepsis
skin abscess
skin injury
therapy effect
wound
LA - English
PY - 2022
SN - ["1939-0041", "1939-5116"]
ST - Catalytic antimicrobial therapy using nanozymes
T2 - Wiley Interdiscip. Rev. Nanomedicine Nanobiotechnology
TI - Catalytic antimicrobial therapy using nanozymes
VL - 14
ID - 13266
ER -
TY - JOUR
AB - Human saliva, a multi-constituent oral fluid, has a high potential for early
diagnosis of disease. Proteomic analysis of saliva holds promise as a non-invasive
method that is advantageous over serum. This non-invasive diagnostic method
represents developing trends in analytical and clinical chemistry. Significant
technological advances in the field of proteomics during the last two decades have
greatly facilitated the research toward this direction. However, these technologies
still require integration and standardization of validation against accepted
clinical and pathologic parameters. In this review, a summary of mass spectrometry-
based technologies of saliva biomarker discovery, potential clinical applications,
and challenges of saliva proteomics have been discussed, as well as latest
technologies of validation and quantification of saliva biomarkers. It is likely
that the use of saliva for early diagnostics of diseases will continue to expand
thus providing a new approach of instrumental investigation for physiologic and
physiological states. These novel biomarkers have obvious clinical utility that
will help to diagnose many diseases at early stage.
AN - rayyan-563560419
AU - Wang, Q.
AU - Yu, Q.
AU - Lin, Q.
AU - Duan, Y.
DO - 10.1016/j.cca.2014.08.037
KW - alternative complement pathway C3 C5 convertase
biological marker
CA 125 antigen
calgranulin A
calgranulin B
catalase
CD59 antigen
CD79b antigen
cyclin D1
cystatin S
endothelin 1
gelatinase B
Hermes antigen
immunoglobulin A
immunoglobulin G
immunoglobulin M
interleukin 1beta
interleukin 6
interleukin 8
maspin
microRNA 31
nuclear receptor coactivator
profilin
somatomedin
thioredoxin
tissue polypeptide antigen
transferrin
vasculotropin A
clinical protocol
early diagnosis
human
mass spectrometry
mouth cancer
pancreas cancer
periodontitis
proteomics
review
saliva analysis
Sjoegren syndrome
stomach cancer
validation study
LA - English
PY - 2014
SN - ["1873-3492", "0009-8981"]
SP - 214-221
ST - Emerging salivary biomarkers by mass spectrometry
T2 - Clin. Chim. Acta
TI - Emerging salivary biomarkers by mass spectrometry
VL - 438
ID - 13793
ER -
TY - JOUR
AB - Objective To evaluate the effect of minocycline hydrochloride (MH)-loaded in-
situ hydrogels on periodontitis of rats. Methods Ligation, high sugar diet, local
vaccination of Porphyromonas gingivalis and intramusclar injection of acetic
predniso-lone were combined to establish the periodontitis of rats. Whether
periodontitis was established successfully or not was determined according to
clinical examination and pathology after 4 weeks. 28 periodontitis rats were
divided into the model group, the positive controll (MH ointment), the blank in-
situ hydrogels (ISG) and MH-loaded ISG groups. The detection index included
gingival index, bleeding index, bleeding on probing, and probing depth before
treatment and 4 weeks after treatment, respectively. Results The inflame-matory and
destruction degrees of periodontal tissues in the positive and MH ISG groups were
better than those of the model and the blank groups. Conclusion The curative effect
of MH-loaded ISG on periodontitis is obvious. It is expected to become a novel
formulation to treat periodontitis in future.
AN - rayyan-563560301
AU - Wang, S. S.
AU - Chen, X.
AU - Du, L. N.
AU - Jin, Y. G.
AU - Ge, C.
AU - Sun, H. Y.
AU - Dong, B.
DO - 10.13220/j.cnki.jipr.2017.04.011
IS - 4
KW - minocycline
prednisolone
animal experiment
animal model
animal tissue
article
bleeding
controlled study
gingival index
hydrogel
nonhuman
ointment
periodontitis
rat
sugar intake
LA - Chinese
PY - 2017
SN - 1674-0440
SP - 353-358
ST - Preparation of minocycline hydrochloride-loaded in-situ hydrogels and effect
on the periodontitis of rats
T2 - J. Int. Pharm. Res.
TI - Preparation of minocycline hydrochloride-loaded in-situ hydrogels and effect
on the periodontitis of rats
VL - 44
ID - 13675
ER -
TY - JOUR
AB - Background: Periodontitis is a localized inflammatory disorder. If not
treated timely, the disease can result in loosening and subsequent loss of teeth.
In situ hydrogel prepared with phase separation technique has emerged as an
attractive alternative for periodontal pocket injection. Objective: Minocycline
(MCL)-loaded in situ hydrogel was prepared composed of poly(lactide-co-glycolide)
(PLGA) and N-methylpyrrolidone (NMP) to improve the topical treatment effect of
periodontitis. Method: A series of reasonable and applicable formulations were
optimized by investigating their syringeability, viscosity and in vitro drug
release. The rheological profiles, antimicrobial activities and pharmacodynamics
were further studied to evaluate its effect on periodontitis treatment. Results:
The prepared MCL/PLGA hydrogel exhibited the characteristic of Newton fluid with
acceptable syringeability. Drug release could last for more than 48 hours with an
acceptable "burst release". It also had obvious antimicrobial activities and
pharmacodynamics efficiency similar to the commercial product, Parocline (R).
Conclusion: MCL/PLGA in situ hydrogel may be a promising clinical formulation for
AN - rayyan-563562015
AU - Wang, X. Q.
AU - Ma, J. L.
AU - Zhu, X. M.
AU - Wang, F.
AU - Zhou, L.
DO - 10.2174/1567201814666171120120421
IS - 5
PY - 2018
SN - ["1567-2018", "1875-5704"]
SP - 664-671
ST - Minocycline-loaded In situ Hydrogel for Periodontitis Treatment
T2 - CURRENT DRUG DELIVERY
TI - Minocycline-loaded In situ Hydrogel for Periodontitis Treatment
VL - 15
ID - 15389
ER -
TY - JOUR
AB - BACKGROUND: With in-depth understanding of the etiology and pathogenesis of
periodontal disease, the direct cause of periodontal connective tissue destruction
is the host immune response, rather than the bacteria itself. A large number of
studies have been made regarding host response modulators and local application of
the periodontal pocket. Chitosan exhibits not only excellent biocompatibility and
biodegradability, but also various promising biological activities, such as broad-
spectrum antibacterial activity and a variety of host regulatorary effects.
OBJECTIVE: To evaluate the therapeutic effects of chitosan-ascorbate on promoting
periodontal tissue healing and regeneration in a rat periodontitis model. METHODS:
Fifty-six Wistar rat models of periodontitis were established and randomly divided
into two groups: experimental and control. The experimental group received
chitosan-ascorbate injection into the pocket bottom, while the control group
received physiological saline injection. At different time points after treatment,
clinical examination, morphometric and histopathologic analyses were performed.
RESULTS AND CONCLUSION: Dental plaque index, gingival index, pocket depth,
attachment loss, and tooth mobility were significantly lower in the experimental
group than in the control group. The largest difference value was 1.18 (28 days),
0.92 (2 days), 0.33 mm (4 days), 0.49 mm (28 days), 1.69 (28 days), respectively.
Alveolar bone lose in the experimental group was (1.18±0.08) mm, (1.10±0.12) mm,
and (1.03±0.08) mm after 0, 2, and 4 weeks of treatment, while it was (1.17±0.11)
mm, (1.31±0.09) mm, and (1.42±0.14) mm in the control group at the corresponding
time points. Histopathologic observation showed that no obvious new attachment
formation in the experimental and control groups. Compared to the control group,
the inflammatory infiltration was significantly lower in the experimental groups,
with the phenomena of regeneration and repair. These findings suggest that
chitosan-ascorbate gels can promote periodontal tissue healing and regeneration in
a rat periodontitis model and can be used as an adjunct to the nonsurgical
periodontal therapy in treatment of periodontitis.
AN - rayyan-563560648
AU - Wang, X.
AU - Jia, H. C.
AU - Feng, Y. M.
AU - Hong, L. H.
DO - 10.3969/j.issn.1673-8225.2010.12.045
IS - 12
KW - ascorbic acid
chitosan
sodium chloride
alveolar bone loss
animal experiment
animal model
animal tissue
article
controlled study
female
gel
gingiva
healing
histopathology
male
morphometry
nonhuman
periodontal disease
periodontitis
rat
therapy effect
tissue regeneration
tooth plaque
LA - English
PY - 2010
SN - 1673-8225
SP - 2268-2272
ST - Chitosan-ascorbate for periodontal tissue healing and regeneration in a rat
periodontitis model: An effectiveness validation
T2 - J. Clin. Rehab. Tissue Eng. Res.
TI - Chitosan-ascorbate for periodontal tissue healing and regeneration in a rat
periodontitis model: An effectiveness validation
VL - 14
ID - 14022
ER -
TY - JOUR
AB - Background: Periodontitis is a localized inflammatory disorder. If not
treated timely, the disease can result in loosening and subsequent loss of teeth.
In situ hydrogel prepared with phase separation technique has emerged as an
attractive alternative for periodontal pocket injection. Objective: Minocycline
(MCL)-loaded in situ hydrogel was prepared composed of poly(lactide-coglycolide)
(PLGA) and N-methylpyrrolidone (NMP) to improve the topical treatment effect of
periodontitis. Method: A series of reasonable and applicable formulations were
optimized by investigating their syringeability, viscosity and in vitro drug
release. The rheological profiles, antimicrobial activities and pharmacodynamics
were further studied to evaluate its effect on periodontitis treatment. Results:
The prepared MCL/PLGA hydrogel exhibited the characteristic of Newton fluid with
acceptable syringeability. Drug release could last for more than 48 hours with an
acceptable “burst release”. It also had obvious antimicrobial activities and
pharmacodynamics efficiency similar to the commercial product, Parocline®.
Conclusion: MCL/PLGA in situ hydrogel may be a promising clinical formulation for
AN - rayyan-563560273
AU - Wang, X.
AU - Ma, J.
AU - Zhu, X.
AU - Wang, F.
AU - Zhou, L.
DO - 10.2174/1567201814666171120120421
IS - 5
minocycline
periocline
polyglactin
prostaglandin E2
alveolar bone loss
animal cell
animal experiment
animal model
animal tissue
article
controlled study
drug effect
drug formulation
gingival index
histopathology
hydrogel
in vitro study
in vivo study
inflammatory cell
male
molecular weight
nonhuman
priority journal
protein expression
rat
room temperature
shear stress
tissue level
tooth cementum
viscosity
zone of inhibition
LA - English
PY - 2018
SN - ["1875-5704", "1567-2018"]
SP - 664-671
ST - Minocycline-loaded in situ hydrogel for periodontitis treatment
TI - Minocycline-loaded in situ hydrogel for periodontitis treatment
VL - 15
ID - 13647
ER -
TY - JOUR
AB - Local drug delivery systems have been proposed for the treatment of
periodontitis, and Hylotelephium purpureum may be a suitable agent for use in such
a system. The present study aimed to formulate a Hylotelephium purpureum gel (HPG)
and evaluate the anti-inflammatory activity and antinociceptive effects of
Hylotelephium purpureum and to assess the duration of action and efficacy of HPG in
the treatment of experimental periodontitis in a KM mouse model. First, an acute
toxicity study was performed, and secondly, xylene-induced mouse-ear edema, acetic
acid-induced mouse peritoneal capillary permeability and carrageenan-induced hind-
paw edema tests were used to investigate the anti-inflammatory activity of the gel.
The acetic acid-induced writhing response and hot-plate tests were used to evaluate
the antinociceptive activity. The therapeutic effects of HPG in experimental
periodontitis were evaluated and minimum inhibitory concentration of the gel was
determined. The results showed that intragastrically administration of 80 ml/kg of
HPG produced no toxic effects. There were statistically significant changes in
gingival indexes and sulcus bleeding indexes in the high-dose HPG-treated group.
The serum levels of superoxide dismutase and glutathione peroxidase were
significantly heightened, while the level of malondialdehyde was decreased. HPG
exhibited 32.7% inhibition of edema, and altered the peritoneal capillary
permeability in mice. The gel had relatively good bacteriostatic and bactericidal
effects. It also exhibited antinociceptive activity, as demonstrated by the acetic
acid-induced writhing response test and hot-plate test. In summary, the present
study demonstrates that HPG is effective in the treatment of experimental
periodontitis.
AN - rayyan-563560260
AU - Wang, X.
AU - Wang, W.
AU - Li, W.
AU - Niu, Z.
AU - Wang, Q.
AU - Zhang, D.
AU - Li, H.
AU - Wang, J.
DO - 10.3892/br.2018.1065
IS - 4
KW - acetic acid
carrageenan
Chinese drug
Hylotelephium purpureum extract
malonaldehyde
plant extract
su xiao ya tong ning ding
tinidazole
unclassified drug
xylene
abdominal cavity
animal experiment
animal model
animal tissue
antinociception
article
capillary permeability
cell infiltration
drug efficacy
drug megadose
ear edema
female
histology
histopathology
hot plate test
male
mouse
nonhuman
osteolysis
pain
paw edema
pH
Prevotella melaninogenica
rat
writhing test
LA - English
PY - 2018
SN - ["2049-9442", "2049-9434"]
SP - 378-384
ST - Evaluation of the efficacy of hylotelephium purpureum gel in the treatment of
T2 - Biomed. Rep.
TI - Evaluation of the efficacy of hylotelephium purpureum gel in the treatment of
VL - 8
ID - 13634
ER -
TY - JOUR
AB - Background(-)-Epigallocatechin Gallate (EGCG) as green tea catechins
possessed antibacterial and anti-inflammatory effects on periodontal disease. This
study was designed to evaluate the clinical and microbiological efficacy of scaling
and root planing (SRP) using EGCG aqueous solution as coolants through a new-type
ultrasonic scaler tip on chronic periodontitis.MethodsThis split-mouth, randomized
clinical trial included 20 patients (2 drop-outs) with chronic periodontitis and
the maxillary contra-lateral sides were allocated into test and control groups
randomly. Through the new-type scaler tip, 762 sites with probing depth (PD)>= 4 mm
were treated by SRP using EGCG solution or distilled water as coolants
respectively. Clinical parameters and red complex pathogens in subgingival
microbiome were evaluated at baseline, 3 and 6 months after
treatments.ResultsDuring 6 months, the SRP plus EGCG medication contributed to
additional PD reduction as 0.33 mm and gain of clinical attachment level as 0.3 mm
compared with SRP alone, and approximate 8% more sites obtained PD reduction >= 2
mm (p<0.05). Meanwhile, the mean relative abundance of Tannerella forsythia was
significantly lower in the combined treatment group (p<0.05).ConclusionThe purified
EGCG showed the potential to improve the outcome of periodontal non-surgical
treatment and the new-type scaler tip provided an alternative vehicle for
subgingival medication.Trial registration The trial was registered in Chinese
Clinical Trial Registry on 15 February 2020 (No.: ChiCTR2000029831, retrospectively
registered). http://www.chictr.org.cn/showprojen.aspx?proj=49441.
AN - rayyan-563562382
AU - Wang, Y. F.
AU - Zeng, J. J.
AU - Yuan, Q.
AU - Luan, Q. X.
DO - 10.1186/s12903-021-01418-1
IS - 1
PY - 2021
SN - 1472-6831
ST - Efficacy of (-)-epigallocatechin gallate delivered by a new-type scaler tip
during scaling and root planing on chronic periodontitis: a split-mouth, randomized
clinical trial
TI - Efficacy of (-)-epigallocatechin gallate delivered by a new-type scaler tip
during scaling and root planing on chronic periodontitis: a split-mouth, randomized
clinical trial
VL - 21
Y2 - 2 y3 - 18
ID - 15756
ER -
TY - JOUR
AB - Periodontitis is a chronic inflammatory disease initiated by pathogenic
biofilms and host immunity that damages tooth-supporting tissues, including the
gingiva, periodontal ligament and alveolar bone. The physiological functions of the
oral cavity, such as saliva secretion and chewing, greatly reduce the residence of
therapeutic drugs in the area of a periodontal lesion. In addition, complex and
diverse pathogenic mechanisms make effectively treating periodontitis difficult.
Therefore, designing advanced local drug delivery systems and rational therapeutic
strategies are the basis for successful periodontitis treatment. Hydrogels have
attracted considerable interest in the field of periodontitis treatment due to
their biocompatibility, biodegradability and convenient administration to the
periodontal pocket. In recent years, the focus of hydrogel research has shifted to
smart stimuli-responsive hydrogels, which can undergo flexible sol-gel transitions
in situ and control drug release in response to stimulation by temperature, light,
pH, ROS, glucose, or enzymes. In this review, we systematically introduce the
development and rational design of emerging smart stimuli-responsive hydrogels for
periodontitis treatment. We also discuss the state-of-the-art therapeutic
strategies of smart hydrogels based on the pathogenesis of periodontitis.
Additionally, the challenges and future research directions of smart hydrogels for
periodontitis treatment are discussed from the perspective of developing efficient
hydrogel delivery systems and potential clinical applications.
AN - rayyan-563559706
AU - Wang, Y.
AU - Li, J.
AU - Tang, M.
AU - Peng, C.
AU - Wang, G.
AU - Wang, J.
AU - Wang, X.
AU - Chang, X.
AU - Guo, J.
AU - Gui, S.
DO - 10.1016/j.biopha.2023.114688
KW - cellulose
chitosan
copolymer
curdlan
enzyme
ether derivative
glucose
hydrogel
poloxamer
smart material
bacterial infection
biomechanics
cytokine production
drug release
freeze drying
gelation
human
in vitro study
inflammation
inflammatory cell
light exposure
mouth flora
mouth infection
mucoadhesion
periodontal pocket
periodontitis
pH
physical chemistry
review
sol-gel
tissue regeneration
LA - English
PY - 2023
SN - ["1950-6007", "0753-3322"]
ST - Smart stimuli-responsive hydrogels for drug delivery in periodontitis
treatment
T2 - Biomed. Pharmacother.
TI - Smart stimuli-responsive hydrogels for drug delivery in periodontitis
treatment
VL - 162
ID - 13080
ER -
TY - JOUR
AB - Pulpitis, periodontitis, jaw bone defect, and temporomandibular joint damage
are common oral and maxillofacial diseases in clinic, but traditional treatments
are unable to restore the structure and function of the injured tissues. Due to
their good biocompatibility, biodegradability, antioxidant effect, anti-
inflammatory activity, and broad-spectrum antimicrobial property, chitosan-based
hydrogels have shown broad applicable prospects in the field of oral tissue
engineering. Quaternization, carboxymethylation, and sulfonation are common
chemical modification strategies to improve the physicochemical properties and
biological functions of chitosan-based hydrogels, while the construction of
hydrogel composite systems via carrying porous microspheres or nanoparticles can
achieve local sequential delivery of diverse drugs or bioactive factors, laying a
solid foundation for the well-organized regeneration of defective tissues. Chemical
cross-linking is commonly employed to fabricate irreversible permanent chitosan
gels, and physical cross-linking enables the formation of reversible gel networks.
Representing suitable scaffold biomaterials, several chitosan-based hydrogels
transplanted with stem cells, growth factors or exosomes have been used in an
attempt to regenerate oral soft and hard tissues. Currently, remarkable advances
have been made in promoting the regeneration of pulp-dentin complex, cementum-
periodontium-alveolar bone complex, jaw bone, and cartilage. However, the clinical
translation of chitosan-based hydrogels still encounters multiple challenges. In
future, more in vivo clinical exploration under the conditions of oral complex
microenvironments should be performed, and the combined application of chitosan-
based hydrogels and a variety of bioactive factors, biomaterials, and state-of-the-
art biotechnologies can be pursued in order to realize multifaceted complete
regeneration of oral tissue.
AN - rayyan-563561088
AU - Wang, Y.
AU - Zou, J.
AU - Cai, M.
AU - Mao, J.
AU - Shi, X.
DO - 10.11817/j.issn.1672-7347.2023.220370
IS - 1
J2 - Zhong Nan Da Xue Xue Bao Yi Xue Ban
KW - *Chitosan/chemistry
Tissue Engineering
Hydrogels/chemistry
Biocompatible Materials/chemistry
Cartilage
Tissue Scaffolds/chemistry
LA - ["eng", "chi"]
N1 - Department of Orthodontics, Center of Stomatology, Tongji Hospital of Tongji
Medical College, Huazhong University of Science and Technology, Wuhan 430030.
wyj_mio@163.com.; School of Stomatology, Tongji Medical College, Huazhong
University of Science and Technology, Wuhan 430030. wyj_mio@163.com.; Hubei
Province Key Laboratory of Oral and Maxillofacial Development and Regeneration,
Wuhan 430022, China. wyj_mio@163.com.; Department of Orthodontics, Center of
Stomatology, Tongji Hospital of Tongji Medical College, Huazhong University of
Science and Technology, Wuhan 430030.; School of Stomatology, Tongji Medical
College, Huazhong University of Science and Technology, Wuhan 430030.; Hubei
Wuhan 430022, China.; Department of Orthodontics, Center of Stomatology, Tongji
Hospital of Tongji Medical College, Huazhong University of Science and Technology,
Wuhan 430030.; School of Stomatology, Tongji Medical College, Huazhong University
of Science and Technology, Wuhan 430030.; Hubei Province Key Laboratory of Oral and
Maxillofacial Development and Regeneration, Wuhan 430022, China.; Department of
Orthodontics, Center of Stomatology, Tongji Hospital of Tongji Medical College,
Huazhong University of Science and Technology, Wuhan 430030.; School of
Stomatology, Tongji Medical College, Huazhong University of Science and Technology,
Wuhan 430030.; Hubei Province Key Laboratory of Oral and Maxillofacial Development
and Regeneration, Wuhan 430022, China.; Department of Orthodontics, Center of
Stomatology, Tongji Hospital of Tongji Medical College, Huazhong University of
Science and Technology, Wuhan 430030.; School of Stomatology, Tongji Medical
College, Huazhong University of Science and Technology, Wuhan 430030.; Hubei
Wuhan 430022, China.; Department of Orthodontics, Center of Stomatology, Tongji
Hospital of Tongji Medical College, Huazhong University of Science and Technology,
Wuhan 430030. dentxin@163.com.; School of Stomatology, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan 430030. dentxin@163.com.;
Hubei Province Key Laboratory of Oral and Maxillofacial Development and
Regeneration, Wuhan 430022, China. dentxin@163.com.
PY - 2023
SN - 1672-7347 (Print)
SP - 138-147
ST - Applicatoin of chitosan-based hydrogel in oral tissue engineering
T2 - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University.
Medical sciences
TI - Applicatoin of chitosan-based hydrogel in oral tissue engineering
VL - 48
Y2 - 1 y3 - 28
ID - 14462
ER -
TY - JOUR
AB - Fermencin SD11, a bacteriocin produced by human orally Lactobacillus
fermentum SD11, was purified, characterized, and optimized in conditions for
bacterial growth and bacteriocin production. Fermencin SD11 was purified using
three steps of ammonium sulfate precipitation, gel filtration chromatography, and
reverse-phase high-performance liquid chromatography. The molecular weight was
found to be 33,000 Da using SDS-PAGE and confirmed as 33,593.4 Da by liquid
chromatography-mass spectrometry. Fermencin SD11 exhibited activity against a wide
range of oral pathogens including cariogenic and periodontogenic pathogens and
Candida. The active activity was stable between 60 - 80 °C in a pH range of 3.0 to
7.0. It was sensitive to proteolytic enzymes (proteinase K and trypsin), but it was
not affected by α-amylase, catalase, lysozyme, and saliva. The optimum conditions
for growth and bacteriocin production of L. fermentum SD11 were cultured at acidic
with pH of 5.0–6.0 at 37 or 40 °C under aerobic or anaerobic conditions for 12 h.
It is promising that L. fermentum SD11 and its bacteriocin may be an alternative
approach for promoting oral health or prevention of oral diseases, e.g., dental
caries and periodontitis, which would require further clinical trials.
AN - rayyan-563560341
AU - Wannun, P.
AU - Piwat, S.
AU - Teanpaisan, R.
DO - 10.1007/s12010-016-2014-y
IS - 4
KW - bacteriocin
fermencin SD11
probiotic agent
unclassified drug
article
bacterial growth
bacterial strain
biomass production
cell density
controlled study
dental caries
drug screening
growth rate
lactic acid bacterium
Lactobacillus fermentum
Lactobacillus gasseri
mouth cavity
mouth disease
nonhuman
periodontitis
pH
protein analysis
saliva
LA - English
PY - 2016
SN - ["1559-0291", "0273-2289"]
SP - 572-582
ST - Purification, Characterization, and Optimum Conditions of Fermencin SD11, a
Bacteriocin Produced by Human Orally Lactobacillus fermentum SD11
T2 - Appl. Biochem. Biotechnol.
TI - Purification, Characterization, and Optimum Conditions of Fermencin SD11, a
Bacteriocin Produced by Human Orally Lactobacillus fermentum SD11
VL - 179
ID - 13715
ER -
TY - JOUR
AB - BACKGROUND: It has been long recognized that periodontal diseases are
infections of the periodontium, comprising the bacterial etiology, an immune
response, and tissue destruction. Treatment strategies aiming primarily at
suppressing or eliminating specific periodontal pathogens include adjunct use of
local and systemic antibiotics as part of nonsurgical periodontal therapy. Unwanted
side effects and resistance of microorganisms toward antibiotics due to their
widespread use have modified the general perception about their efficacy. Research
in phytosciences has revealed various medicinal plants offering a new choice of
optional antimicrobial therapy. Cymbopogon citratus, Stapf. (lemongrass) is a
popular medicinal plant. At a concentration ≤2%, lemongrass essential oil inhibits
the growth of several kinds of microorganisms including periodontal pathogens,
especially the reference strains Actinomyces naeslundii and Porphyromonas
gingivalis, which were resistant to tetracycline hydrochloride. AIMS: To evaluate
the efficacy of locally delivered 2% lemongrass essential oil in gel form as an
adjunct to scaling and root planing, as compared to scaling and root planing alone
for the treatment of chronic periodontitis. MATERIALS AND METHODS: 2% Lemongrass
essential oil gel was prepared and placed in moderate to deep periodontal pockets
after scaling and root planing. RESULTS: Statistically significant reduction in
probing depth and gingival index and gain in relative attachment level were noted
in the experimental group as compared to the control group at 1 and 3 months.
CONCLUSION: Locally delivered 2% lemongrass essential oil gel offers a new choice
of safe and effective adjunct to scaling and root planing in periodontal therapy.
AN - rayyan-563561272
AU - Warad, S. B.
AU - Kolar, S. S.
AU - Kalburgi, V.
AU - Kalburgi, N. B.
DO - 10.4103/0257-7941.131973
IS - 4
J2 - Anc Sci Life
LA - eng
N1 - Department of Periodontics, P. M. N. M. Dental College and Hospital,
Bagalkot, Karnataka, India.; Department of Periodontics, P. M. N. M. Dental College
and Hospital, Bagalkot, Karnataka, India.; Department of Periodontics, P. M. N. M.
Dental College and Hospital, Bagalkot, Karnataka, India.; Department of
Periodontics, P. M. N. M. Dental College and Hospital, Bagalkot, Karnataka, India.
PY - 2013
SN - 0257-7941 (Print)
SP - 205-11
ST - Lemongrass essential oil gel as a local drug delivery agent for the treatment
of periodontitis
T2 - Ancient science of life
TI - Lemongrass essential oil gel as a local drug delivery agent for the treatment
of periodontitis
VL - 32
Y2 - 4
ID - 14646
ER -
TY - JOUR
AB - The purpose of this study was to assess the efficacy of two different
BriteSmile hydrogen peroxide (H2O2) gels in a split-arch protocol for whitening
teeth in a clinical setting when used in conjunction with a BriteSmile BS4000 lamp.
Fifteen subjects were enrolled into a single-center clinical trial. The efficacy of
the BriteSmile BS4000 lamp using both 15% H2O2 and 25% H2O2 gel formulations was
tested. Study subjects were concurrently exposed to the whitening lamp with the 15%
H2O2 gel placed on half of their anterior teeth and the 25% H2O2 gel on the other
half for a total light and gel exposure of 60 minutes. The clinical data collected
were shade score, gingival health, and dentinal hypersensitivity self-assessment.
Changes in tooth shade were better for subjects exposed to the 25% gel and the
dental whitening lamp (average 8.0 shade changes) compared to subjects exposed to
the 15% gel and dental whitening lamp (average 7.6 shade changes) immediately after
treatment. The same held true at the 7-day follow-up (25% gel average 7.4 shade
changes versus 15% gel average 7.3 shade changes). However, these differences were
not statistically significant. No reports of irritation of gingival soft tissues
were documented. The relative changes in mean sensitivity scores were similar for
both groups with no significant differences in mean sensitivity scores between the
groups. Both concentrations of H2O2 gel and the whitening lamp combined gave study
subjects an average of 8.0 (25% gel) and 7.6 (15% gel) shade changes immediately
after treatment. The 7-day follow-up examination resulted in a regression of
lightest to an average of 7.4 (25% gel) and 7.3 (15% gel). It was concluded that
the use of the chairside whitening light and either 15% or 25% hydrogen peroxide
gel is safe and effective for whitening teeth in 1 hour.
AN - rayyan-563560554
AU - Ward, M.
AU - Felix, H.
IS - 4
adult
aged
article
canine tooth
clinical trial
color
comparative study
dental procedure
drug effect
female
follow up
gel
gingiva
gingivitis
human
incisor
devices
male
methodology
middle aged
mouth mucosa
pathology
photochemotherapy
safety
time
treatment outcome
LA - English
PY - 2012
SN - 1548-8578
SP - 286-291
ST - A clinical evaluation comparing two H2O2 concentrations used with a light-
assisted chairside tooth whitening system
TI - A clinical evaluation comparing two H2O2 concentrations used with a light-
assisted chairside tooth whitening system
VL - 33
ID - 13928
ER -
TY - JOUR
AB - Periodontitis is a chronic destructive inflammatory disease associated with
periodontopathic bacteria. In addition, autoantigens such as collagen and heat
shock proteins (hsp) have been suggested to play a role. Established periodontal
lesions are characterized by dense infiltrations of immune cells such as cytokine-
producing CD4+ and CD8+ T cells. CD4+ T cells specific for Prevotella intermedia
can be isolated from lesional gingiva, suggesting an active role for CD4+ T cells
in the response to this bacterium. We therefore investigated the characteristics of
a panel of 13 P. intermedia- specific CD4+ T cells generated from the peripheral
blood of a patient with chronic adult periodontitis. All 13 P. intermedia-specific
CD4+ T cells recognized the antigens in the context of HLA-DR. The T cell clones
were mainly classified as Th0, producing comparable amounts of interferon-gamma
(IFN-γ) and IL-4, and Th2, producing high amounts of IL-4 and almost no IFN- γ.
None of the P. intermedia-specific T cell clones recognized antigens of the
periodontopathic bacteria Actinobacillus actinomycetemcomitans and Porphyromonas
gingivalis and of the autoantigens collagen and hsp. The reactivity profile of the
T cell clones to size-fractionated cell envelope antigens of P. intermedia
indicated that P. intermedia-specific CD4+ T cell clones recognize probably five
different antigen specificities in the context of the MHC class II molecules, DR7
or DR15. These results suggest that a broad panel of cell-associated protein
antigens play a role in the induction of P. intermedia-specific CD4+ T cell
response.
AN - rayyan-563561023
AU - Wassenaar, A.
AU - Reinhardus, C.
AU - Abraham-Inpijn, L.
AU - Snijders, A.
AU - Kievits, F.
DO - 10.1046/j.1365-2249.1998.00630.x
IS - 1
KW - autoantigen
bacterial antigen
collagen
envelope protein
gamma interferon
heat shock protein
HLA antigen class 1
HLA DR antigen
interleukin 4
antigen specificity
article
bacterial membrane
chronic disease
controlled study
helper cell
human
human cell
periodontitis
priority journal
LA - English
PY - 1998
SN - 0009-9104
SP - 105-110
ST - Characteristics of Prevotella intermedia-specific CD4+ T cell clones from
peripheral blood of a chronic adult periodontitis patient
T2 - Clin. Exp. Immunol.
TI - Characteristics of Prevotella intermedia-specific CD4+ T cell clones from
peripheral blood of a chronic adult periodontitis patient
VL - 113
ID - 14397
ER -
TY - JOUR
AB - The susceptibility of guided bone regeneration (GBR) material to infection by
pathogens at wound sites during bone healing has often been overlooked. The
objective of this study was the synthesis and characterization of a potential
material for antibacterial GBR application. In the current study, the mechanical
strength and biocompatibility of a composite restoration material-made of oxidized
hyaluronic acid (HA)/type I collagen hydrogel integrated with tricalcium phosphate
(beta-TCP) using a natural crosslinking agent, oligomeric proanthocyanidins (OPCs)-
were evaluated. The suitability of the material as a carrier matrix for
antibacterial applications was evaluated by following the drug-release profile of
tetracycline loaded within the composite. Results indicated that this composite
material had a high swelling ratio of 420% and mechanical strength of 25 kPa while
remaining at more than 60% of the weight after 30 days of an in vitro degradation
test with good biocompatibility in promoting the proliferation of MG-63 cells. Drug
release studies further showed that 93% of the tetracycline was released after 5
days, which supports this GBR material's capability to release antibacterial drugs
while keeping other required GBR material design functions.
AN - rayyan-563562428
AU - Wei, Y.
AU - Chang, Y. H.
AU - Liu, C. J.
AU - Chung, R. J.
IS - 2
PY - 2018
SN - 1999-4923
ST - Integrated Oxidized-Hyaluronic Acid/Collagen Hydrogel with beta-TCP Using
Proanthocyanidins as a Crosslinker for Drug Delivery
T2 - PHARMACEUTICS
TI - Integrated Oxidized-Hyaluronic Acid/Collagen Hydrogel with beta-TCP Using
Proanthocyanidins as a Crosslinker for Drug Delivery
VL - 10
Y2 - 6
ID - 15802
ER -
TY - JOUR
AB - The susceptibility of guided bone regeneration (GBR) material to infection by
pathogens at wound sites during bone healing has often been overlooked. The
objective of this study was the synthesis and characterization of a potential
material for antibacterial GBR application. In the current study, the mechanical
strength and biocompatibility of a composite restoration material—made of oxidized
hyaluronic acid (HA)/type I collagen hydrogel integrated with tricalcium phosphate
(β-TCP) using a natural crosslinking agent, oligomeric proanthocyanidins (OPCs)—
were evaluated. The suitability of the material as a carrier matrix for
antibacterial applications was evaluated by following the drug-release profile of
tetracycline loaded within the composite. Results indicated that this composite
material had a high swelling ratio of 420% and mechanical strength of 25 kPa while
remaining at more than 60% of the weight after 30 days of an in vitro degradation
test with good biocompatibility in promoting the proliferation of MG-63 cells. Drug
release studies further showed that 93% of the tetracycline was released after 5
days, which supports this GBR material’s capability to release antibacterial drugs
while keeping other required GBR material design functions.
AN - rayyan-563560255
AU - Wei, Y.
AU - Chang, Y. H.
AU - Liu, C. J.
AU - Chung, R. J.
IS - 2
collagen
hyaluronic acid
proanthocyanidin derivative
article
biocompatibility
biodegradation
bone regeneration
cell proliferation
clinical protocol
controlled study
degradation
drug release
guided bone regeneration
human
human cell
hydrogel
oligomerization
osteoblast
oxidation
tissue engineering
LA - English
PY - 2018
SN - 1999-4923
ST - Integrated oxidized-hyaluronic acid/collagen hydrogel with β-TCP using
proanthocyanidins as a crosslinker for drug delivery
T2 - Pharmaceutics
TI - Integrated oxidized-hyaluronic acid/collagen hydrogel with β-TCP using
proanthocyanidins as a crosslinker for drug delivery
VL - 10
ID - 13629
ER -
TY - JOUR
AB - Periodontitis is a chronic inflammation of the soft tissue surrounding and
supporting the teeth, which causes periodontal structural damage, alveolar bone
resorption, and even tooth loss. Its prevalence is very high, with nearly 60% of
the global population affected. Hence, periodontitis is an important public health
concern, and the development of effective healing treatments for oral diseases is a
major target of the health sciences. Currently, the application of local drug
delivery systems (LDDS) as an adjunctive therapy to scaling and root planning (SRP)
in periodontitis is a promising strategy, giving higher efficacy and fewer side
effects by controlling drug release. The cornerstone of successful periodontitis
therapy is to select an appropriate bioactive agent and route of administration. In
this context, this review highlights applications of LDDS with different properties
in the treatment of periodontitis with or without systemic diseases, in order to
reveal existing challenges and future research directions.
AN - rayyan-563559992
AU - Wei, Y.
AU - Deng, Y.
AU - Ma, S.
AU - Ran, M.
AU - Jia, Y.
AU - Meng, J.
AU - Han, F.
AU - Gou, J.
AU - Yin, T.
AU - He, H.
AU - Wang, Y.
AU - Zhang, Y.
AU - Tang, X.
DO - 10.1016/j.jconrel.2021.03.041
KW - matrix band
antibiotic agent
gel
microsphere
molecular scaffold
nanofiber
nanofilm
nanoparticle
alveolar bone
bacterial infection
disease association
disease model
high-sucrose diet
human
inflammation
ligation
local drug delivery system
local thread ligation
nonhuman
pathogenesis
periodontitis
pharmacodynamics
priority journal
review
systemic disease
tissue repair
LA - English
PY - 2021
SN - ["1873-4995", "0168-3659"]
SP - 269-282
ST - Local drug delivery systems as therapeutic strategies against periodontitis:
A systematic review
TI - Local drug delivery systems as therapeutic strategies against periodontitis:
A systematic review
VL - 333
ID - 13366
ER -
TY - JOUR
AB - Nanosilver-loaded PMMA bone cement (BC-AgNp) is a novel cement developed as a
replacement for conventional cements. Despite its favorable properties and
antibacterial activity, BC-AgNp still lacks biodegradability and bioactivity.
Hence, we investigated doping with bioactive glasses (BGs) to create a new
bioactive BC characterized by time-varying porosity and gradual release of AgNp.
The BC Cemex was used as the base material and modified simultaneously with the
AgNp and BGs: melted 45S5 and 13-93B3 glasses with various particle sizes and sol-
gel derived SiO2/CaO microparticles. The effect of BG addition was examined by
microscopic analysis, an assessment of setting parameters, wettability, FTIR and
UV-VIS spectroscopy, mechanical testing, and hemo- and cytocompatibility and
antibacterial efficiency studies. The results show that it is possible to
incorporate various BGs into BC-AgNp, which leads to different properties depending
on the type and size of BGs. The smaller particles of melted BGs showed higher
porosity and better antibacterial properties with the moderate deterioration of
mechanical properties. The sol-gel derived BGs, however, displayed a tendency for
agglomeration and random distribution in BC-AgNp. The BGs with greater solubility
more efficiently improve the antibacterial properties of BC-AgNp. Besides, the
unreacted MMA monomer release could negatively influence the cellular response.
Despite that, cements doped with different BGs are suitable for medical
applications.
AN - rayyan-563559997
AU - Wekwejt, M.
AU - Chen, S.
AU - Kaczmarek-Szczepańska, B.
AU - Nadolska, M.
AU - Łukowicz, K.
AU - Pałubicka, A.
AU - Michno, A.
AU - Osyczka, A. M.
AU - Michálek, M.
AU - Zieliński, A.
DO - 10.1039/d1bm00079a
IS - 8
spectrometer
antibiotic agent
barium sulfate
benzoyl peroxide
bone cement
silver nanoparticle
article
biocompatibility
controlled study
environmental temperature
erythrocyte
hemolysis
human
human cell
methicillin resistance
microscopy
nonhuman
particle size
polymerization
porosity
priority journal
thrombocyte
ultraviolet visible spectroscopy
viscoelasticity
wettability
LA - English
PY - 2021
SN - ["2047-4849", "2047-4830"]
SP - 3112-3126
ST - Nanosilver-loaded PMMA bone cement doped with different bioactive glasses-
evaluation of cytocompatibility, antibacterial activity, and mechanical properties
T2 - Biomater. Sci.
TI - Nanosilver-loaded PMMA bone cement doped with different bioactive glasses-
evaluation of cytocompatibility, antibacterial activity, and mechanical properties
VL - 9
ID - 13371
ER -
TY - JOUR
AB - Objective: This prospective clinical study aim was to analyze the effect of
the probiotic Lactobacillus reuteri Prodentis lozenges on salivary microbiome of
subjects wearing fixed orthodontic appliances. Methods: Saliva samples were
collected prior to consumption and 14th-day post probiotic lozenges consumption
(n=40, age 18–23). Oral hygiene index-score (OHI-S) and papilla bleeding index
(PBI) were recorded. The salivary microbiome was profiled by next-generation
sequencing using the V3-V4 region of 16S-rRNA. Microbial composition, diversity and
taxonomic biomarkers were analysed in comparison to probiotic intervention and the
clinical characteristics of the cohort using standard bioinformatics tools.
Results: The diversity and bacterial community structures did not change
significantly in salivary microbiome of periodontally healthy subjects during
short-term probiotic intervention. Probiotic consumption correlated with reduction
of OHI and PBI scores (50% reduction of scores, P<0.001). The reduction of clinical
indices was evident in conjunction with significantly reduced abundance of oral
pathogens, such as Porphyromonas pasteri, Treponema sp., Fretibacterium
fastidiosum, Kingella oralis and Propionibacterium acnes. Conclusion: Short-term
probiotic intervention helped maintaining good oral health in patients undergoing
fixed orthodontic therapy. Although overall oral microbiome structure remained
largely unchanged, a significant alteration in the abundance of health and disease-
associated species highlighted the beneficial effect of probiotic.
AN - rayyan-563559910
AU - Widyarman, A. S.
AU - Udawatte, N. S.
AU - Roeslan, M. O.
AU - Rizal, M. I.
AU - Richi, M.
AU - Kusnoto, J.
AU - Seneviratne, C. J.
DO - 10.1080/20002297.2022.2067103
IS - 1
KW - DNA purification kit
fixed orthodontic appliance
fluorometer
genetic analyzer
protective equipment
spectrophotometer
toothbrush
antibiotic agent
probiotic agent
RNA 16S
toothpaste
Actinobacteria
Actinomyces
adult
Anoxybacillus
article
Bacteroidetes
bioinformatics
bleeding
clinical article
cohort analysis
controlled study
dietary supplement
DNA extraction
female
Firmicutes
Fusobacterium
gingival index
Haemophilus
Haemophilus parainfluenzae
human
Kingella
Lactobacillus reuteri
Leptotrichia
lower lip
lozenge
male
Microbacterium
microbial community
microbiome
mouth hygiene
Neisseria
Neisseria elongata
oral hygiene index
pandemic
periodontal index
phenotype
Porphyromonas
Prevotella
principal coordinate analysis
Proteobacteria
quality control
receiver operating characteristic
Rothia
Rothia dentocariosa
saliva
Selenomonas
Severe acute respiratory syndrome coronavirus 2
Streptococcus
tooth papilla
Treponema
Veillonella
iSeq 100
Nanodrop 2000
LA - English
PY - 2022
SN - 2000-2297
ST - Short- term effect of probiotic Lactobacillus reuteri consumption on the
salivary microbiome profile of subjects undergoing orthodontic treatment with fixed
appliances
T2 - J. Oral Microbiol.
TI - Short- term effect of probiotic Lactobacillus reuteri consumption on the
salivary microbiome profile of subjects undergoing orthodontic treatment with fixed
appliances
VL - 14
ID - 13284
ER -
TY - JOUR
AN - rayyan-563562477
AU - Wilson, M.
DO - 10.3109/08910609309141320
IS - 3
PY - 1993
SN - 0891-060X
SP - 143-145
ST - LABORATORY ASSESSMENT OF ANTIMICROBIAL AGENTS FOR THE TREATMENT OF CHRONIC
PERIODONTITIS
T2 - MICROBIAL ECOLOGY IN HEALTH AND DISEASE
TI - LABORATORY ASSESSMENT OF ANTIMICROBIAL AGENTS FOR THE TREATMENT OF CHRONIC
PERIODONTITIS
VL - 6
Y2 - 5
ID - 15851
ER -
TY - JOUR
AB - The basic design for human clinical trials which examine prevention of
gingivitis recurrence is well known. However, the anti-gingivitis efficacy of
triclosan-containing dentifrices has not been routinely demonstrated using this
design, regardless of formulation. In an effort to better understand the subtleties
of design which show triclosan efficacy, a study was undertaken to prospectively
test how subjects with a range of baseline disease levels (which encompassed the
range of gingivitis severity documented in the triclosan literature) benefit from a
triclosan dentifrice. This trial was a randomized, double-blind, parallel group,
six-month study where subjects brushed twice daily with either
triclosan/pyrophosphate, triclosan/copolymer, triclosan placebo or sodium fluoride
control (NaF) dentifrice following a prophylaxis. Both gingivitis and bleeding were
measured using the Löe-Silness Gingival Index (GI) and plaque was measured using
the Turesky Plaque Index. Comparisons between treatments were performed using an
analysis of covariance. At month 3, the triclosan/pyrophosphate group had a
relative mean plaque benefit of 14.4% versus the triclosan placebo group (with an
associated p-value of 0.004), and subjects using triclosan/copolymer had a mean
reduction in GI bleeding sites of 16.2% relative to those brushing with the NaF
control (with an associated p-value of 0.031). The overall results did not
demonstrate a treatment effect for gingivitis or plaque for either triclosan-
containing dentifrice at month 6. There was evidence of modest anti-gingivitis
efficacy in the triclosan placebo. In an effort to better understand how baseline
disease severity may have impacted the trial outcome, additional analyses were
performed to investigate whether the magnitude of a triclosan effect was related to
baseline gingivitis levels. An analysis of covariance model incorporating a
baseline group interaction effect indicated that the magnitude of the treatment
differences depended on the baseline scores The effect was most pronounced for GI
bleeding sites. Further analysis showed that differences between triclosan
dentifrices and the NaF control dentifrice were only present for subjects with more
than 33 to 63 bleeding sites, depending on the specific comparison. These findings
were illustrated through a series of subset analyses on subjects with > or = 20
(entire study population), > or = 31, > or = 40 and > or = 45 baseline GI bleeding
sites. The magnitude of the treatment effect for both GI and GI bleeding sites
increased with each succeeding subset. Unlike that required for other antimicrobial
agents used in oral care products, these findings suggest that a study design which
includes subjects with more severe gingivitis at baseline has the required
sensitivity to demonstrate treatment benefits for triclosan dentifrices.
AN - rayyan-563561446
AU - Winston, J. L.
AU - Bartizek, R. D.
AU - McClanahan, S. F.
AU - Mau, M. S.
AU - Beiswanger, B. B.
IS - 6
J2 - J Clin Dent
KW - Adult
Cariostatic Agents/therapeutic use
Complex Mixtures
Dental Plaque Index
Dentifrices/*therapeutic use
Diphosphates/therapeutic use
Double-Blind Method
Female
Fluorides
Gingival Hemorrhage/prevention & control
Gingivitis/classification/*prevention & control
Humans
Male
Maleates/therapeutic use
Periodontal Index
Placebos
Polyvinyls/therapeutic use
Prospective Studies
Research Design
Sensitivity and Specificity
Silicic Acid
Silicon Dioxide/therapeutic use
Sodium Fluoride/therapeutic use
Toothpastes
Treatment Outcome
Triclosan/*therapeutic use
LA - eng
N1 - Health Care Research Center, The Procter & Gamble Company, Mason, OH, USA.
PY - 2002
SN - 0895-8831 (Print)
SP - 240-8
ST - A clinical methods study of the effects of triclosan dentifrices on
gingivitis over six months
TI - A clinical methods study of the effects of triclosan dentifrices on
gingivitis over six months
VL - 13
ID - 14820
ER -
TY - JOUR
AB - AIM: The aim of this study was to determine the antioxidant activity of
Indonesian propolis gel 5% in Wistar rats alveolar bone, toward malondialdehyde
serum levels and osteoblast cells number caused by orthodontic tooth movement
(OTM). METHODS: This was an experimental study using the post-test only group
design. The samples were 28 male Wistar rats, divided into four groups: G1 (control
group) – group without OTM and without propolis, G2 – group without OTM and with
propolis, G3 – group with OTM and without propolis, and G4 – group with OTM and
with propolis. Propolis available in the form of 5% gel and 30 gf helical spring
force of OTM applied. Spring was applied in rat maxilla incisors. OTM treatment was
given 17 days, and on day 18, blood samples were taken for the measurement of
malondialdehyde levels, then tested using the ELISA test. Variable of osteoblast
was calculated histologically using hematoxylin-eosin staining. The data of
malondialdehyde level and the osteoblast number obtained were tested using one-way
ANOVA. RESULTS: The result indicated that osteoblast number was higher with
propolis application compared to those without propolis in the control group and
orthodontic tooth treatment group (G2>G1, 23.97 ± 2.95 vs. 18.63 ± 3.04 and G4>G3,
34.17 ± 5.57 vs. 28.26 ± 2.62) with significant difference (p < 0.05). Propolis
application also reduces malondialdehyde serum level when compared to both groups
without propolis (control and OTM group) (G2<G1, 1.02 ± 0.18 nmol/ml vs. 1.55 ±
0.24 nmol/ml and G4<G3 1.29 ± 0.22 nmol/ml vs. 1.83 ± 0.21 nmol/ml) and
significantly different (p < 0.05). OTM increased the malondialdehyde level
compared to the control group, with a significant difference (p < 0.05).
CONCLUSION: Propolis gel 5% application can reduce malondialdehyde serum level and
could increase the number of osteoblast.
AN - rayyan-563560143
AU - Wiwekowati, W.
AU - Ma’ruf, M. T.
AU - Walianto, S.
AU - Sabir, A.
AU - Widyadharma, I. P. E.
DO - 10.3889/oamjms.2020.3984
KW - malonaldehyde
propolis
alveolar bone
animal experiment
animal model
animal tissue
apitherapy
article
blood sampling
bone development
cell count
controlled study
experimental study
histopathology
Indonesia
male
nonhuman
orthodontics
osteoblast
oxidative stress
periodontal disease
rat
LA - English
PY - 2020
SN - 1857-9655
SP - 100-104
ST - Indonesian propolis reduces malondialdehyde level and increase osteoblast
cell number in alveolar bone of wistar rats with orthodontic tooth movement
TI - Indonesian propolis reduces malondialdehyde level and increase osteoblast
cell number in alveolar bone of wistar rats with orthodontic tooth movement
VL - 8
ID - 13517
ER -
TY - JOUR
AB - Porous titanium granules (PTG) may have potential as an osteoconductive bone
graft substitute to treat peri-implant osseous defects. The aim of this study was
to analyze clinical and radiographic outcomes of peri-implant osseous defects after
treatment with PTG. This prospective, randomized, case-control, clinical 12-month
study compared open-flap debridement and surface decontamination with titanium
curettes and 24% ethylenediaminetetraacetic acid gel (n = 16) to the same protocol
but with the addition of PTG (n = 16). One-, two-, and three-wall infrabony defects
were included. Patients were given amoxicillin and metronidazole 3 days before
surgery and for 7 days afterwards. Implants were submerged and allowed to heal for
6 months. Probing pocket depths, bleeding on probing, implant stability using
resonance frequency analysis, and radiographic evaluation were performed at
baseline and at 12 months. The threshold for significance was set at .05. Change in
radiographic defect height and percent fill of the peri-implant osseous defect
significantly favored patients treated with PTG. Both treatment modalities
demonstrated significant improvements in probing pocket depth, but significant
differences between groups were not observed. The PTG-treated implants showed an
increase in implant stability quotient (ISQ) of 1.6 units, compared with a decrease
of 0.7 ISQ for the control group. No adverse effects were associated with PTG
treatment. Reconstruction with PTG resulted in significantly better radiographic
peri-implant defect fill compared with controls; however, the results do not
necessarily imply reosseointegration or osseointegration of PTG particles.
Improvements in clinical parameters were seen in both groups, but no differences
between groups were demonstrated.
AN - rayyan-563560556
AU - Wohlfahrt, J. C.
AU - Lyngstadaas, S. P.
AU - Rønold, H. J.
AU - Saxegaard, E.
AU - Ellingsen, J. E.
AU - Karlsson, S.
AU - Aass, A. M.
IS - 2
KW - disinfectant agent
edetic acid
titanium
aged
article
bone prosthesis
bone regeneration
case control study
comparative study
controlled study
curettage
debridement
disease course
female
gingiva bleeding
human
male
methodology
middle aged
oral surgery
periimplantitis
periodontal pocket
physiology
porosity
prospective study
surgical flaps
tooth implant
tooth prosthesis
treatment outcome
vibration
LA - English
PY - 2012
SN - 1942-4434
SP - 401-410
ST - Porous titanium granules in the surgical treatment of peri-implant osseous
defects: a randomized clinical trial
T2 - Int J Oral Maxillofac Implants
TI - Porous titanium granules in the surgical treatment of peri-implant osseous
defects: a randomized clinical trial
VL - 27
ID - 13930
ER -
TY - JOUR
AB - AIM: The purpose of this retrospective analysis was to examine what effect,
if any, the time elapsed between an individual's last episode of scaling and root
planing and subsequent treatment with a sustained-release doxycycline hyclate gel
(DH) alone or scaling and root planing alone (SRP) would have upon adult
periodontitis. METHODS: A total of 207 subjects were included in the DH group and
210 patients in the SRP group. Periodontitis was defined as those sites which
presented with pocket depths > or =5 mm and exhibited bleeding upon probing. In
both DH and SRP groups, 3 sub-groups of subjects were identified according to their
last episode of scaling and root planing prior to the study baseline: within 2 to 6
months, >6 but < or =12 months, and one or more times in their life but not within
the last 12 months. Each study site was treated twice over a 9-month study period,
once at baseline and again at 4 months. Data from the study sites at 4, 6, and 9
months were then evaluated for changes in probing depth, clinical attachment level,
and bleeding upon probing. RESULTS: At the 9-month evaluation, all sub-groups in
the DH and SRP treatment arms presented with improvement in the measured clinical
parameters, as compared to baseline. No significant differences were observed in
the measured periodontal indices among the study sites between the three sub-groups
for either treatment. CONCLUSIONS: It is concluded that the time interval since the
last episode of scaling and root planing had no observable effect on the results
achieved when treating periodontitis sites with locally delivered doxycycline
hyclate alone or scaling and root planing alone. The treatment of periodontitis
sites with locally delivered doxycycline hyclate resulted in clinical improvement
comparable to scaling and root planing irrespective of the patient's prophylaxis
frequency.
AN - rayyan-563560916
AU - Wolinsky, L. E.
AU - Camargo, P. M.
AU - Polson, A.
AU - Ryder, M.
AU - Garrett, S.
IS - 12
doxycycline
doxycycline hyclate
drug derivative
adult
aged
article
gel
human
middle aged
periodontics
periodontitis
retrospective study
time
LA - English
PY - 2001
SN - 0303-6979
SP - 1115-1120
ST - The significance of prior mechanical therapy for changes of periodontal
status achieved by local delivery of a doxycyclinehyclate containing gel
TI - The significance of prior mechanical therapy for changes of periodontal
status achieved by local delivery of a doxycyclinehyclate containing gel
VL - 28
ID - 14290
ER -
TY - JOUR
AB - OBJECTIVES: This study aimed to synthesise a drug-delivery system based on a
porous polymer hydrogel, with antimicrobial properties against Porphyromonas
gingivalis and potential to be used in tissue regeneration. MATERIAL AND METHODS:
2-Hydroxyethyl methacrylate monomers were polymerised using thermal and
photoactivation in the presence of silver nitrate (AgNO3) and/or chlorhexidine
digluconate. Poly-2-hydroxyethyl methacrylate (pHEMA) hydrogels containing silver
nanoparticles (AgNPs) and/or 0.12% chlorhexidine (CHX) were produced and
characterised using cryo-SEM and confocal microscopy. Hydrogel degradation and
leaching of AgNP were tested for 1.5 months. The antimicrobial properties were
tested against P. gingivalis using broth culture system and disk diffusion tests.
RESULTS: Our methodology manufactured porous polymeric hydrogels doped with AgNPs
and CHX. Hydrogels showed a successful delivery of CHX and sustainable release of
AgNPs in a steady hydrogel degradation rate determined based on the weight loss of
samples. Hydrogels with AgNPs or CHX had a significant antimicrobial effect against
P. gingivalis, with CHX-hydrogels exhibiting a stronger effect than AgNP-hydrogels
in the short-term assessment. AgNP-CHX hydrogels showed a compounded antimicrobial
effect, whereas control hydrogels containing neither AgNPs nor CHX had no influence
on bacterial growth (P < .05). CONCLUSIONS: The dual-cured pHEMA hydrogel loaded
with antimicrobial agents proved to be an efficient drug-delivery system against
periodontopathogens, with the potential to be used as a scaffold for tissue
regeneration.
AN - rayyan-563559712
AU - Wong, P. Y.
AU - Soo, S.
AU - Wong, E. S. C.
AU - Praveen, P.
AU - Clode, P.
AU - Baker, M. V.
AU - Matsubara, V. H.
DO - 10.1016/j.identj.2023.01.002
IS - 3
KW - 2 hydroxyethyl methacrylate
antiinfective agent
hydrogel
metal nanoparticle
polymacon
silver
human
periodontal disease
LA - English
PY - 2023
SN - 1875-595X
SP - 354-361
ST - A Novel Antimicrobial Hydrogel for the Management of Periodontal Diseases
T2 - Int Dent J
TI - A Novel Antimicrobial Hydrogel for the Management of Periodontal Diseases
VL - 73
ID - 13086
ER -
TY - JOUR
AN - rayyan-563561521
AU - Wong, P. Y.
AU - Soo, S.
AU - Wong, E. S. C.
AU - Praveen, P.
AU - Clode, P.
AU - Baker, M. V.
DO - 10.1016/j.identj.2023.01.002
IS - 3
PY - 2023
SP - 354-361
ST - A Novel Antimicrobial Hydrogel for the Management of Periodontal Diseases:
ANTIMICROBIAL HYDROGEL TO TREAT PERIODONTITIS
T2 - International Dental Journal
TI - A Novel Antimicrobial Hydrogel for the Management of Periodontal Diseases:
ANTIMICROBIAL HYDROGEL TO TREAT PERIODONTITIS
85150387637&doi=10.1016%2fj.identj.2023.01.002&partnerID=40&md5=dc8cb66a59358511744
be8a83fe3b470
VL - 73
ID - 14895
ER -
TY - JOUR
AB - OBJECTIVES: This study aimed to synthesise a drug-delivery system based on a
porous polymer hydrogel, with antimicrobial properties against Porphyromonas
gingivalis and potential to be used in tissue regeneration. MATERIAL AND METHODS:
2-Hydroxyethyl methacrylate monomers were polymerised using thermal and
photoactivation in the presence of silver nitrate (AgNO(3)) and/or chlorhexidine
digluconate. Poly-2-hydroxyethyl methacrylate (pHEMA) hydrogels containing silver
nanoparticles (AgNPs) and/or 0.12% chlorhexidine (CHX) were produced and
characterised using cryo-SEM and confocal microscopy. Hydrogel degradation and
leaching of AgNP were tested for 1.5 months. The antimicrobial properties were
tested against P. gingivalis using broth culture system and disk diffusion tests.
RESULTS: Our methodology manufactured porous polymeric hydrogels doped with AgNPs
and CHX. Hydrogels showed a successful delivery of CHX and sustainable release of
AgNPs in a steady hydrogel degradation rate determined based on the weight loss of
samples. Hydrogels with AgNPs or CHX had a significant antimicrobial effect against
P. gingivalis, with CHX-hydrogels exhibiting a stronger effect than AgNP-hydrogels
in the short-term assessment. AgNP-CHX hydrogels showed a compounded antimicrobial
effect, whereas control hydrogels containing neither AgNPs nor CHX had no influence
on bacterial growth (P < .05). CONCLUSIONS: The dual-cured pHEMA hydrogel loaded
with antimicrobial agents proved to be an efficient drug-delivery system against
periodontopathogens, with the potential to be used as a scaffold for tissue
regeneration.
AN - rayyan-563560795
AU - Wong, P. Y.
AU - Soo, S.
AU - Wong, E. S.
AU - Praveen, P.
AU - Clode, P.
AU - Baker, M. V.
DO - 10.1016/j.identj.2023.01.002
IS - 3
J2 - Int Dent J
KW - Humans
Hydrogels
Anti-Bacterial Agents/pharmacology/therapeutic use
*Metal Nanoparticles
Polyhydroxyethyl Methacrylate
Silver/pharmacology/therapeutic use
*Anti-Infective Agents/pharmacology/therapeutic use
*Periodontal Diseases/drug therapy
LA - eng
N1 - UWA Dental School, The University of Western Australia, Perth, Western
Australia, Australia.; UWA Dental School, The University of Western Australia,
Perth, Western Australia, Australia.; UWA Dental School, The University of Western
Australia, Perth, Western Australia, Australia.; School of Molecular Sciences, The
University of Western Australia, Perth, Western Australia, Australia.; Centre for
Microscopy, Characterisation, and Analysis and School of Biological Sciences, The
University of Western Australia, Perth, Western Australia, Australia.; School of
Molecular Sciences, The University of Western Australia, Perth, Western Australia,
Australia.; UWA Dental School, The University of Western Australia, Perth, Western
Australia, Australia.
PY - 2023
SP - 354-361
ST - A Novel Antimicrobial Hydrogel for the Management of Periodontal Diseases
T2 - International dental journal
TI - A Novel Antimicrobial Hydrogel for the Management of Periodontal Diseases
VL - 73
Y2 - 6
ID - 14169
ER -
TY - JOUR
AB - The periodontium is an integrated, functional unit of multiple tissues
surrounding and supporting the tooth, including but not limited to cementum (CM),
periodontal ligament (PDL) and alveolar bone (AB). Periodontal tissues can be
destructed by chronic periodontal disease, which can lead to tooth loss. In support
of the treatment for periodontally diseased tooth, various biomaterials have been
applied starting as a contact inhibition membrane in the guided tissue regeneration
(GTR) that is the current gold standard in dental clinic. Recently, various
biomaterials have been prepared in a form of tissue engineering scaffold to
facilitate the regeneration of damaged periodontal tissues. From a physical
substrate to support healing of a single type of periodontal tissue to multi-
phase/bioactive scaffold system to guide an integrated regeneration of
periodontium, technologies for scaffold fabrication have emerged in last years.
This review covers the recent advancements in development of scaffolds designed for
periodontal tissue regeneration and their efficacy tested in vitro and in vivo.
Pros and Cons of different biomaterials and design parameters implemented for
periodontal tissue regeneration are also discussed, including future perspectives.
AN - rayyan-563559952
AU - Woo, H. N.
AU - Cho, Y. J.
AU - Tarafder, S.
AU - Lee, C. H.
DO - 10.1016/j.bioactmat.2021.03.012
IS - 10
KW - implant
suture
tissue scaffold
aurantiin
bioceramics
biomaterial
bromelain
chitosan
collagen
erythropoietin
gelatin
glycerophosphate
hydrogel
ibuprofen
metronidazole
mevinolin
piroxicam
polycaprolactone
polymer
polyvinyl alcohol
progranulin
silver nanoparticle
simvastatin
tannin
tetracycline
alcohol abuse
alveolar bone
bacterial spore
bone graft
calcium stone
cells by body anatomy
contact inhibition
drug efficacy
gene therapy
healing
in vitro study
in vivo study
neutrophil
nonhuman
periodontal disease
periodontitis
periodontium
review
tissue regeneration
tooth cementum
tooth plaque
LA - English
PY - 2021
SN - 2452-199X
SP - 3328-3342
ST - The recent advances in scaffolds for integrated periodontal regeneration
T2 - Bioact. Mater.
TI - The recent advances in scaffolds for integrated periodontal regeneration
VL - 6
ID - 13326
ER -
TY - JOUR
AB - An electrospun degradable polycarbonate urethane (PCNU) nanofiber scaffold
loaded with antibiotic was investigated in terms of antibacterial efficacy and cell
compatibility for potential use in gingival tissue engineering. Antimicrobial
oligomer (AO), a compound which consists of two molecules of ciprofloxacin (CF)
covalently bound via hydrolysable linkages to triethylene glycol (TEG), was
incorporated via a one-step blend electrospinning process using a single solvent
system at 7 and 15% w/w equivalent CF with respect to the PCNU. The oligomeric form
of the drug was used to overcome the challenge of drug aggregation and burst
release when antibiotics are incorporated as free drug. Electrospinning parameters
were optimized to obtain scaffolds with similar alignment and fiber diameter to
non-drug loaded fibers. AO that diffused from the fibers was hydrolysed to release
CF slowly and in a linear manner over the duration of the study, whereas scaffolds
with CF at the same concentration but in free form showed a burst release within 1
h with no further release throughout the study duration. Human gingival fibroblast
(HGF) adhesion and spreading was dependent on the concentration and form the CF was
loaded (AO vs. free CF), which was attributed in part to differences in scaffold
surface chemistry. Surface segregation of AO was quantified using surface-resolved
X-ray photoelectron spectroscopy (XPS). These findings are encouraging and support
further investigation for the use of AO as a means of attenuating the rapid release
of drug loaded into nanofibers. The study also demonstrates through quantitative
measures that drug additives have the potential to surface-locate without phase
separating from the fibers, leading to fast dissolution and differential fibroblast
cell attachment.
AN - rayyan-563560305
AU - Wright, M. E.
AU - Parrag, I. C.
AU - Yang, M.
AU - Santerre, J. P.
DO - 10.1016/j.jconrel.2017.02.008
KW - ciprofloxacin
molecular scaffold
oligomer
polyurethan
triethylene glycol
article
cell adhesion
controlled study
dispersity
drug release
electrospinning
fibroblast
human
human cell
in vitro study
molecular weight
priority journal
surface property
LA - English
PY - 2017
SN - ["1873-4995", "0168-3659"]
SP - 107-115
ST - Electrospun polyurethane nanofiber scaffolds with ciprofloxacin oligomer
versus free ciprofloxacin: Effect on drug release and cell attachment
TI - Electrospun polyurethane nanofiber scaffolds with ciprofloxacin oligomer
versus free ciprofloxacin: Effect on drug release and cell attachment
VL - 250
ID - 13679
ER -
TY - JOUR
AB - Periodontal diseases are some of the most widespread oral afflictions, and
they are labeled as chronic infections caused by the accumulation of bacteria in
dental plaque that produces localized inflammation of the periodontium. The use of
local drug delivery systems to treat periodontal diseases has received greater
attention, because the active substance is targeted directly to the affected area,
which minimizes its systemic side effects. Therefore, the purpose of the
investigation was to develop and characterize different types of gel formulations-
bigel, hydrogel and oleogel-as local delivery systems containing metronidazole
(MET), which can be applied to the oral mucosa. The influence of the formulation
type on the mechanical, rheological and mucoadhesive properties were examined.
Moreover, in vitro release of metronidazole, its ex vivo permeation through buccal
porcine mucosa and antimicrobial activity measured by the plate diffusion method
were estimated. It was found that the gel formulations obtained were non-Newtonian
systems, showing a shear-thinning behavior and thixotropic properties with good
textural features such as firmness, compressibility and adhesiveness. Moreover, the
preparations designed possessed beneficial mucoadhesive properties. The formulated
hydrogels and bigels containing micronized MET were considered as better
formulations in terms of drug release and antimicrobial activity compared to
commercially available metronidazole ointment. An ex vivo permeation study with the
use of porcine buccal mucosa demonstrated that the bigel formulation was
characterized by higher initial permeability rate providing a fast therapeutic
effect with simultaneous moderate retention in mucosal tissue to decrease the risk
of local cytotoxicity.
AN - rayyan-563561114
AU - Wróblewska, M.
AU - Szymańska, E.
AU - Szekalska, M.
AU - Winnicka, K.
DO - 10.3390/polym12030680
IS - 3
LA - eng
N1 - Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical
University of Białystok, A. Mickiewicza 2C, 15-222 Białystok, Poland.; Department
of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Białystok,
A. Mickiewicza 2C, 15-222 Białystok, Poland.; Department of Pharmaceutical
Technology, Faculty of Pharmacy, Medical University of Białystok, A. Mickiewicza
2C, 15-222 Białystok, Poland.; Department of Pharmaceutical Technology, Faculty of
Pharmacy, Medical University of Białystok, A. Mickiewicza 2C, 15-222 Białystok,
Poland.
PY - 2020
ST - Different Types of Gel Carriers as Metronidazole Delivery Systems to the Oral
Mucosa
T2 - Polymers
TI - Different Types of Gel Carriers as Metronidazole Delivery Systems to the Oral
Mucosa
VL - 12
Y2 - 3 y3 - 19
ID - 14488
ER -
TY - JOUR
AB - Periodontal diseases are some of the most widespread oral afflictions, and
they are labeled as chronic infections caused by the accumulation of bacteria in
dental plaque that produces localized inflammation of the periodontium. The use of
local drug delivery systems to treat periodontal diseases has received greater
attention, because the active substance is targeted directly to the affected area,
which minimizes its systemic side effects. Therefore, the purpose of the
investigation was to develop and characterize different types of gel formulations-
bigel, hydrogel and oleogel-as local delivery systems containing metronidazole
(MET), which can be applied to the oral mucosa. The influence of the formulation
type on the mechanical, rheological and mucoadhesive properties were examined.
Moreover, in vitro release of metronidazole, its ex vivo permeation through buccal
porcine mucosa and antimicrobial activity measured by the plate diffusion method
were estimated. It was found that the gel formulations obtained were non-Newtonian
systems, showing a shear-thinning behavior and thixotropic properties with good
textural features such as firmness, compressibility and adhesiveness. Moreover, the
preparations designed possessed beneficial mucoadhesive properties. The formulated
hydrogels and bigels containing micronized MET were considered as better
formulations in terms of drug release and antimicrobial activity compared to
commercially available metronidazole ointment. An ex vivo permeation study with the
use of porcine buccal mucosa demonstrated that the bigel formulation was
characterized by higher initial permeability rate providing a fast therapeutic
effect with simultaneous moderate retention in mucosal tissue to decrease the risk
of local cytotoxicity.
AN - rayyan-563562317
AU - Wroblewska, M.
AU - Szymanska, E.
AU - Szekalska, M.
AU - Winnicka, K.
DO - 10.3390/polym12030680
IS - 3
PY - 2020
SN - 2073-4360
ST - Different Types of Gel Carriers as Metronidazole Delivery Systems to the Oral
Mucosa
T2 - POLYMERS
TI - Different Types of Gel Carriers as Metronidazole Delivery Systems to the Oral
Mucosa
VL - 12
Y2 - 3
ID - 15691
ER -
TY - JOUR
AB - Periodontitis is a chronic infection and tissue-destructive disease which is
considered as the major cause of tooth loss. However, satisfactory clinical
treatment for the disease has yet to be achieved. Herein, we designed an injectable
thermo-sensitive hydrogel consisting of hydroxypropyl methylcellulose (HPMC),
hyaluronic acid (HA) and glycerol (GI), and further loaded with Bomidin (FP), a
recombinant antimicrobial peptide (AMP), the physicochemical and biological
characteristics were subsequently investigated in vitro. The results indicated that
the prepared hydrogel can be injected and changes phase in situ at desirable
temperature. Also, a three-dimensional network structure and cell compatibility
were observed. Importantly, the FP-embedded hydrogels exhibited strong
antibacterial activities against oral pathogens Porphyromonas gingivalis (P.
gingivalis), Staphylococcus aureus (S. aureus), and Escherichia coli (E. coli).
These findings indicated our hydrogel possesses not only good fluidity, stable
thermosensitivity but also preferable biocompatibility and antibacterial
properties, thus demonstrate promising potential for application in periodontal
treatment.
AN - rayyan-563562168
AU - Wu, D.
AU - Wang, P.
AU - Wu, Q. R.
AU - Chu, C. H. H.
AU - Lei, C.
AU - Wu, W.
AU - Ma, S. S.
AU - Lv, J. X.
AU - Tang, C. B.
DO - 10.1557/s43578-022-00706-y
IS - 18
PY - 2022
SN - ["0884-2914", "2044-5326"]
SP - 3021-3032
ST - Preparation and characterization of Bomidin-loaded thermosensitive hydrogel
for periodontal application
T2 - JOURNAL OF MATERIALS RESEARCH
TI - Preparation and characterization of Bomidin-loaded thermosensitive hydrogel
VL - 37
Y2 - 9 y3 - 28
ID - 15542
ER -
TY - JOUR
AN - rayyan-563561495
AU - Wu, D.
AU - Wang, P.
AU - Wu, Q.
AU - Chu, C. H.
AU - Lei, C.
AU - Wu, W.
AU - Ma, S.
AU - Lv, J.
AU - Tang, C.
DO - 10.1557/s43578-022-00706-y
IS - 18
PY - 2022
SP - 3021-3032
ST - Preparation and characterization of Bomidin-loaded thermosensitive hydrogel
T2 - Journal of Materials Research
TI - Preparation and characterization of Bomidin-loaded thermosensitive hydrogel
85137422463&doi=10.1557%2fs43578-022-00706-
y&partnerID=40&md5=9aa9a8efb431ee45e74ace6a7291d4fb
VL - 37
ID - 14869
ER -
TY - JOUR
AB - The guided tissue regeneration technique is an effective approach to repair
periodontal defect. However, collagen barrier membranes used clinically lose
stability easily, leading to soft tissue invasion, surgical site infection, and
failure of osteogenesis. An ideal barrier membrane should possess proper
antibacterial, osteoconductive activities, and favorable biodegradation. In this
study, zinc oxide nanoparticles were homogeneously incorporated into the chitin
hydrogel (ChT-1%ZnO) through one-step dissolution and regeneration method from
alkaline/urea solution the first time. The remaining weights of ChT-1%ZnO in 150 mu
g/mL lysozyme solution was 52% after 5 weeks soaking. ChT-1%ZnO showed statistical
antibacterial activities for P. gingivalis and S. aureus at 6 h, 12 h, and 24 h.
Moreover, ChT-1%ZnO exhibits osteogenesis promotion in vitro, and it was further
evaluated with rat periodontal defect model in vivo. The cemento-enamel junction
value in ChT-1%ZnO group is 1.608 mm, presenting a statistical difference compared
with no-membrane (1.825 mm) and ChT group (1.685 mm) after 8 weeks postoperatively.
AN - rayyan-563562188
AU - Wu, T.
AU - Huang, L.
AU - Sun, J.
AU - Sun, J. H.
AU - Yan, Q.
AU - Duan, B.
AU - Zhang, L. N.
AU - Shi, B.
DO - 10.1016/j.carbpol.2021.118276
PY - 2021
SN - ["0144-8617", "1879-1344"]
ST - Multifunctional chitin-based barrier membrane with antibacterial and
osteogenic activities for the treatment of periodontal disease
TI - Multifunctional chitin-based barrier membrane with antibacterial and
VL - 269
Y2 - 10 y3 - 1
ID - 15562
ER -
TY - JOUR
AB - The guided tissue regeneration technique is an effective approach to repair
periodontal defect. However, collagen barrier membranes used clinically lose
stability easily, leading to soft tissue invasion, surgical site infection, and
failure of osteogenesis. An ideal barrier membrane should possess proper
antibacterial, osteoconductive activities, and favorable biodegradation. In this
study, zinc oxide nanoparticles were homogeneously incorporated into the chitin
hydrogel (ChT-1%ZnO) through one-step dissolution and regeneration method from
alkaline/urea solution the first time. The remaining weights of ChT-1%ZnO in 150
μg/mL lysozyme solution was 52% after 5 weeks soaking. ChT-1%ZnO showed statistical
antibacterial activities for P. gingivalis and S. aureus at 6 h, 12 h, and 24 h.
Moreover, ChT-1%ZnO exhibits osteogenesis promotion in vitro, and it was further
evaluated with rat periodontal defect model in vivo. The cemento-enamel junction
value in ChT-1%ZnO group is 1.608 mm, presenting a statistical difference compared
with no-membrane (1.825 mm) and ChT group (1.685 mm) after 8 weeks postoperatively.
AN - rayyan-563559958
AU - Wu, T.
AU - Huang, L.
AU - Sun, J.
AU - Yan, Q.
AU - Duan, B.
AU - Zhang, L.
AU - Shi, B.
DO - 10.1016/j.carbpol.2021.118276
animal model
article
biodegradability
controlled study
in vitro study
in vivo study
male
nonhuman
ossification
periodontal disease
rat
regeneration
antiinfective agent
chitin
endogenous compound
hydrogel
lysozyme
urea
LA - English
PY - 2021
SN - 1879-1344
SP - 118276
ST - Multifunctional chitin-based barrier membrane with antibacterial and
TI - Multifunctional chitin-based barrier membrane with antibacterial and
VL - 269
ID - 13332
ER -
TY - JOUR
AB - Background: Cell–cell communication is an essential process to respond to
biological stimuli and sustain the micro environmental homeostasis of human
periodontal ligament stem cells (hPDLSCs). Connective tissue growth factor (CTGF),
a critical secreted matrix protein, exhibits significant tasks in regulating the
cell-cell and cell-matrix interactions. This study aimed to explore the
relationship between CTGF and cell communication and the underlying mechanism.
Methods: qRT-PCR was used to detect CCN family, connexin, and pannexin family
expression in hPDLSCs. Stimulation with CTGF, cell migration assay was performed to
examine the wound repair. The scrape loading/dye transfer assay was employed to
access lucifer Yellow molecules transfer efficiency mediated by cell-cell
communication. Connexin43 (Cx43), Pannexin1 (Panx1), MAPK, and the PI3K/Akt
signaling pathway proteins were examined via Western blotting. Immunofluorescence
was applied to visualize the localization of specific proteins within cells.
Corresponding pathway inhibitors were applied to hPDLSCs to detect Cx43, Panx1
expression, and intercellular communication induced by CTGF. Results: Our result
showed that CTGF was the second most expressed CCN family member in hPDLSCs. Cx43,
and Panx1 were the most widely expressed gap junction hemichannels in hPDLSCs. CTGF
enhanced hPDLSCs migration in a dose-dependent manner. CTGF promoted cell-cell
communication by up-regulating Cx43 and Panx1. CTGF induced Akt, JNK, and p38
phosphorylation and subcellular relocation. Inhibiting corresponding pathways
reduced Cx43 expression, thereby weakening CTGF-induced cell-cell communication.
However, the Panx1 expression in CTGF-treated hPDLSCs mainly depended on PI3K/Akt
signaling. Conclusion: We provided novel evidence that CTGF promoted cell-cell
communication in hPDLSCs through MAPK and PI3K pathway.
AN - rayyan-563559891
AU - Wu, Z.
AU - Chen, S.
AU - He, Y.
AU - Zhang, D.
AU - Zou, S.
AU - Xie, J.
AU - Zhou, C.
DO - 10.1002/JPER.21-0339
IS - 3
culture medium
microscope
pipette
scalpel blade
SYBR Premix ExTaq II
beta actin
carbenoxolone
connective tissue growth factor
connexin 43
cytoskeleton protein
dye
gap junction protein
lucifer yellow
paraformaldehyde
streptomycin
synaptophysin
triton x 100
Akt signaling
article
cell communication
cell migration
cell migration assay
cognitive control network
connexon
controlled study
cytoskeleton
fetal bovine serum
gap junction
gene
gene expression
human
human cell
immunofluorescence
intercellular signaling
JNK signaling
MAPK signaling
phase contrast microscopy
Pi3K/Akt signaling
protein expression
signal transduction
upregulation
Western blotting
wound healing
wound healing assay
iCycler
LA - English
PY - 2022
SN - 0022-3492
SP - e60-e72
ST - Connective tissue growth factor promotes cell-to-cell communication in human
periodontal ligament stem cells via MAPK and PI3K pathway
TI - Connective tissue growth factor promotes cell-to-cell communication in human
periodontal ligament stem cells via MAPK and PI3K pathway
VL - 93
ID - 13265
ER -
TY - JOUR
AN - rayyan-563560850
AU - Wynn, R. L.
IS - 1
aloesin
antifungal agent
antiinfective agent
antioxidant
antivirus agent
clindamycin
collagen
cyclooxygenase 2
mannose 6 phosphate
plant extract
polysaccharide
scavenger
unclassified drug
Aloe vera
analgesia
angiogenesis
antifungal activity
antiviral activity
aphthous stomatitis
arthritis
burn
Candida albicans
cell proliferation
cold injury
dentistry
drug effect
fibroma
gingivitis
human
Influenza virus
medicinal plant
morality
nonhuman
osteitis
oxygenation
prospective study
protein synthesis
Pseudorabies virus
psoriasis
psychotherapy
review
tooth extraction
Varicella zoster virus
vascularization
wound healing
LA - English
PY - 2005
SN - 0363-6771
SP - 6-9
ST - Aloe vera gel: Update for dentistry
T2 - Gen. Dent.
TI - Aloe vera gel: Update for dentistry
VL - 53
ID - 14224
ER -
TY - JOUR
AB - So far, little phenotypic heterogeneity has been detected in cultured oral
treponemes with trypsin-like proteolytic activity, and all have been assigned to
the species Treponema denticola. However, comparisons of protein patterns and
antigen expression in our collection of proteolytic oral treponemes occasionally
identified isolates with a unique phenotype; e.g. strain OMZ 830 (=ATCC 700768),
which qualified as a 'pathogen-related oral spirochaete' due to the presence of a
∼37 kDa protein reactive with the Treponema pallidum FlaA-specific mAb H9-2. In
addition to such single isolates, a homogeneous group of seven independent strains
is described that were highly motile, medium-sized, proteolytic but asaccharolytic
spirochaetes and were cultured from human gingivitis, periodontitis and acute
necrotizing ulcerative gingivitis in medium OMIZ-Pat supplemented with 1% human
serum and antibiotics. Growth of these spirochaetes in OMIZ-Pat was not dependent
on, but was stimulated by, human or bovine serum. Carbohydrates were neither
required nor stimulatory for growth. The protein and antigen patterns of total cell
extracts of these organisms separated by SDS-PAGE were distinct from those of all
previously cultured spirochaetes, with highest similarity to T. denticola. The
novel spirochaete has a 2:4:2 arrangement of the periplasmic flagella, similar to
T. denticola. However, the flagellin pattern as detected by immunostaining or
glycan staining of Western blots readily distinguished the novel group from T.
denticola. Also, distinct from reference strains of T. denticola, none of the novel
isolates displayed sialidase or dentilisin activities, both of which are expressed
by most strains of T. denticola. Trypsin-like activity and other enzymes as
detected by API ZYM test were similar to those of T. denticola. The status of a
novel species is supported by the 16S rRNA gene sequence, with 98.5% similarity to
its closest cultured relative, T. denticola. The name Treponema putidum sp. nov. is
proposed (type strain OMZ 758T=ATCC 700334T = CIP 108088T). © 2004 IUMS.
AN - rayyan-563560863
AU - Wyss, C.
AU - Moter, A.
AU - Choi, B. K.
AU - Dewhirst, F. E.
AU - Xue, Y.
AU - Schüpbach, P.
AU - Göbel, U. B.
AU - Paster, B. J.
AU - Guggenheim, B.
DO - 10.1099/ijs.0.02806-0
IS - 4
bacterial antigen
bacterial enzyme
bacterial protein
carbohydrate
cell extract
flagellin
glycan
monoclonal antibody
RNA 16S
sialidase
trypsin
antibody specificity
antigen expression
article
bacterial flagellum
bacterial growth
bacterial strain
bacterium culture
bacterium isolate
bacterium isolation
controlled study
culture medium
cytoplasm
enzyme activity
enzyme analysis
gene sequence
gingivitis
human
immunochemistry
molecular weight
new species
nomenclature
nonhuman
nucleotide sequence
periodontitis
phenotype
priority journal
protein analysis
protein degradation
protein expression
sequence analysis
species comparison
spirochete
Treponema
Treponema denticola
Treponema pallidum
Treponema putidum
Vincent stomatitis
Western blotting
LA - English
PY - 2004
SN - 1466-5026
SP - 1117-1122
ST - Treponema putidum sp. nov., a medium-sized proteolytic spirochaete isolated
from lesions of human periodontitis and acute necrotizing ulcerative gingivitis
T2 - Int. J. Syst. Evol. Microbiol.
TI - Treponema putidum sp. nov., a medium-sized proteolytic spirochaete isolated
from lesions of human periodontitis and acute necrotizing ulcerative gingivitis
VL - 54
ID - 14237
ER -
TY - JOUR
AB - The oral and maxillofacial regions have complex anatomical structures and
different tissue types, which have vital health and aesthetic functions.
Biodegradable metals (BMs) is a promising bioactive materials to treat oral and
maxillofacial diseases. This review summarizes the research status and future
research directions of BMs for oral and maxillofacial applications. Mg-based BMs
and Zn-based BMs for bone fracture fixation systems, and guided bone regeneration
(GBR) membranes, are discussed in detail. Zn-based BMs with a moderate degradation
rate and superior mechanical properties for GBR membranes show great potential for
clinical translation. Fe-based BMs have a relatively low degradation rate and
insoluble degradation products, which greatly limit their application and clinical
translation. Furthermore, we proposed potential future research directions for BMs
in the oral and maxillofacial regions, including 3D printed BM bone scaffolds,
surface modification for BMs GBR membranes, and BMs containing hydrogels for
cartilage regeneration, soft tissue regeneration, and nerve regeneration. Taken
together, the progress made in the development of BMs in oral and maxillofacial
regions has laid a foundation for further clinical translation.
AN - rayyan-563559944
AU - Xia, D.
AU - Yang, F.
AU - Zheng, Y.
AU - Liu, Y.
AU - Zhou, Y.
DO - 10.1016/j.bioactmat.2021.01.011
IS - 11
KW - biodegradable implant
bone cement
calcium
calcium silicate
chitosan
copper
doxycycline
hydrogel
iron
magnesium
microsphere
nanocomposite
nanofiber
polymer
zinc
angiogenesis
apoptosis
biocompatibility
biodegradation
biofilm
biomechanics
bone conduction
bone density
bone development
bone graft
bone regeneration
bone tissue
ceramics
cytotoxicity
dental surgeon
epithelization
fracture
fracture fixation
human
mouth disease
ossification
osteoblast
osteoporosis
review
soft tissue
tissue regeneration
tissue repair
LA - English
PY - 2021
SN - 2452-199X
SP - 4186-4208
ST - Research status of biodegradable metals designed for oral and maxillofacial
applications: A review
T2 - Bioact. Mater.
TI - Research status of biodegradable metals designed for oral and maxillofacial
applications: A review
VL - 6
ID - 13318
ER -
TY - JOUR
AB - A novel glucose-sensitive chitosanepolyethylene oxide (CS/PEO = 1:0.5-1:2.5)
hydrogel with controlled release of metronidazole (MNZ) was obtained by chemical
cross-linking and immobilization of glucose oxidase (GO(x)). The hydrogel was
characterized by Fourier-transformed infrared spectroscopy (FTIR), compressive
mechanical test, rheological analysis, cytotoxicity test, and antibacterial test
against Porphyromonas gingivalis. The study found that the CS-PEO composite
hydrogel possessed significantly better mechanical properties and biocompatibility
than a single-component hydrogel. This might result from the physical cross-linking
and formation of semi-interpenetrating network (semi-IPN). In addition, this novel
hydrogel has a self-regulating ability to release MNZ in response to the
environmental glucose stimulus. Specifically, it released more drugs at higher
glucose concentration, thus can lead to a greater ability to inhibit P. gingivalis.
This study has demonstrated the glucose-sensitive antibacterial hydrogel has a
great potential as a new therapeutic material for treatment or prevention of
periodontitis in diabetic patients. (C) 2015 Elsevier Ltd. All rights reserved.
AN - rayyan-563562057
AU - Xiao, Y.
AU - Gong, T.
AU - Jiang, Y.
AU - Wang, Y. P.
AU - Wen, Z. Z. T.
AU - Zhou, S. B.
AU - Bao, C. Y.
AU - Xu, X. M.
DO - 10.1016/j.polymer.2015.11.016
PY - 2016
SN - ["0032-3861", "1873-2291"]
SP - 1-10
ST - Fabrication and characterization of a glucose-sensitive antibacterial
chitosan-polyethylene oxide hydrogel
T2 - POLYMER
TI - Fabrication and characterization of a glucose-sensitive antibacterial
chitosan-polyethylene oxide hydrogel
VL - 82
Y2 - 1 y3 - 15
ID - 15431
ER -
TY - JOUR
AB - A novel glucose-sensitive chitosan-polyethylene oxide (CS/PEO =1:0.5~1:2.5)
hydrogel with controlled release of metronidazole (MNZ) was obtained by chemical
cross-linking and immobilization of glucose oxidase (GO(x)). The hydrogel was
characterized by Fourier-transformed infrared spectroscopy (FTIR), compressive
mechanical test, rheological analysis, cytotoxicity test, and antibacterial test
against Porphyromonas gingivalis. The study found that the CS-PEO composite
hydrogel possessed significantly better mechanical properties and biocompatibility
than a single-component hydrogel. This might result from the physical cross-linking
and formation of semi-interpenetrating network (semi-IPN). In addition, this novel
hydrogel has self-regulate ability to release MNZ in response to the environmental
glucose stimulus. Specifically, it released more drugs at higher glucose
concentration, thus can lead to a greater ability to inhibit Porphyromonas
gingivalis. This study has demonstrated the glucose-sensitive antibacterial
hydrogel has a great potential as a new therapeutic material for treatment or
prevention of periodontitis in diabetic patients.
AN - rayyan-563560809
AU - Xiao, Y.
AU - Gong, T.
AU - Jiang, Y.
AU - Wang, Y.
AU - Wen, Z. T.
AU - Zhou, S.
AU - Bao, C.
AU - Xu, X.
DO - 10.1016/j.polymer.2015.11.016
J2 - Polymer (Guildf)
LA - eng
N1 - State Key Laboratory of Oral Diseases, West China School of Stomatology,
Sichuan University, NO.14, 3rd Section of Ren Min Nan Rd. Chengdu, 610041, Sichuan,
China; Department of Comprehensive Dentistry and Biomaterials, Louisiana State
University Health Sciences Center, School of Dentistry, 1100 Florida Avenue, New
Orleans, LA 70119, USA.; School of Materials Science and Engineering, Key
Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest
Jiaotong University, No.111, 1st Section of North Second Ring Rd. Chengdu 610031,
Sichuan, China.; State Key Laboratory of Oral Diseases, West China School of
Stomatology, Sichuan University, NO.14, 3rd Section of Ren Min Nan Rd. Chengdu,
610041, Sichuan, China.; Department of Comprehensive Dentistry and Biomaterials,
Louisiana State University Health Sciences Center, School of Dentistry, 1100
Florida Avenue, New Orleans, LA 70119, USA.; Department of Comprehensive Dentistry
and Biomaterials, Louisiana State University Health Sciences Center, School of
Dentistry, 1100 Florida Avenue, New Orleans, LA 70119, USA.; School of Materials
Science and Engineering, Key Laboratory of Advanced Technologies of Materials,
Ministry of Education, Southwest Jiaotong University, No.111, 1st Section of North
Second Ring Rd. Chengdu 610031, Sichuan, China.; State Key Laboratory of Oral
Diseases, West China School of Stomatology, Sichuan University, NO.14, 3rd Section
of Ren Min Nan Rd. Chengdu, 610041, Sichuan, China.; Department of Comprehensive
Dentistry and Biomaterials, Louisiana State University Health Sciences Center,
School of Dentistry, 1100 Florida Avenue, New Orleans, LA 70119, USA.
PY - 2016
SN - 0032-3861 (Print)
SP - 1-10
ST - Fabrication and Characterization of a Glucose-sensitive Antibacterial
Chitosan-Polyethylene Oxide Hydrogel
T2 - Polymer
TI - Fabrication and Characterization of a Glucose-sensitive Antibacterial
Chitosan-Polyethylene Oxide Hydrogel
VL - 82
Y2 - 1 y3 - 15
ID - 14183
ER -
TY - JOUR
AB - Inflammation and trauma destroy the tooth-supporting tissue, leading to the
loss of oral function and the difficulty of denture restoration. Guided tissue
regeneration (GTR) is a technique based on a barrier membrane designed to restrict
soft tissue invasion and maintain the space for bone regeneration. This study
examined a new formulation to prepare methacrylated carboxymethyl chitosan (CMCS-
MA) hydrogel as a barrier membrane that could be crosslinked under visible-light
irradiation. This new CMCS-MA hydrogel showed fast light-curing, good
biocompatibility, and could be degraded by lysozyme. Further, the physicochemical
property, cytotoxicity and antibacterial activity of the CMCS-MA hydrogels can be
adjusted by varying the degree of substitution of methacrylic acid (DS) in a
certain range. Thus, the biocompatible and biodegradable CMCS-MA hydrogels may have
a promising application in periodontal tissue regeneration with convenience and
flexibility.
AN - rayyan-563562373
AU - Xing, X. J.
AU - Su, J. J.
AU - Liu, Y.
AU - Lin, H. L.
AU - Wang, Y. H.
AU - Cheng, H.
DO - 10.1016/j.colsurfb.2022.112760
PY - 2022
SN - ["0927-7765", "1873-4367"]
ST - A novel visible light-curing chitosan-based hydrogel membrane for guided
tissue regeneration
T2 - COLLOIDS AND SURFACES B-BIOINTERFACES
TI - A novel visible light-curing chitosan-based hydrogel membrane for guided
tissue regeneration
VL - 218
Y2 - 10
ID - 15747
ER -
TY - JOUR
AB - Inflammation and trauma destroy the tooth-supporting tissue, leading to the
loss of oral function and the difficulty of denture restoration. Guided tissue
regeneration (GTR) is a technique based on a barrier membrane designed to restrict
soft tissue invasion and maintain the space for bone regeneration. This study
examined a new formulation to prepare methacrylated carboxymethyl chitosan (CMCS-
MA) hydrogel as a barrier membrane that could be crosslinked under visible-light
irradiation. This new CMCS-MA hydrogel showed fast light-curing, good
biocompatibility, and could be degraded by lysozyme. Further, the physicochemical
property, cytotoxicity and antibacterial activity of the CMCS-MA hydrogels can be
adjusted by varying the degree of substitution of methacrylic acid (DS) in a
certain range. Thus, the biocompatible and biodegradable CMCS-MA hydrogels may have
a promising application in periodontal tissue regeneration with convenience and
flexibility.
AN - rayyan-563559800
AU - Xing, X.
AU - Su, J.
AU - Liu, Y.
AU - Lin, H.
AU - Wang, Y.
AU - Cheng, H.
DO - 10.1016/j.colsurfb.2022.112760
KW - biomaterial
chitosan
hydrogel
methacrylic acid
animal cell
animal experiment
animal tissue
antibiotic prophylaxis
article
biodegradability
cell encapsulation
cell proliferation
cell viability
controlled study
deacetylation
male
methylation
morphology
nonhuman
particle size
rat
tissue regeneration
X ray diffraction
LA - English
PY - 2022
SN - ["1873-4367", "0927-7765"]
ST - A novel visible light-curing chitosan-based hydrogel membrane for guided
tissue regeneration
T2 - Colloids Surf. B Biointerfaces
TI - A novel visible light-curing chitosan-based hydrogel membrane for guided
tissue regeneration
VL - 218
ID - 13174
ER -
TY - JOUR
AB - Periodontal regeneration is defined as regeneration of the tooth-supporting
tissues including cementum, periodontal ligament, and alveolar bone. Guided tissue
regeneration (GTR) has been demonstrated to be an effective technique to achieve
periodontal regeneration. In the GTR procedures, various kinds of membranes play
important roles. Chitosan, a deacetylated derivative of chitin, is biocompatible,
biodegradable, and antimicrobial. It acts as hydrating agent and possesses tissue
healing and osteoinducing effect. Chitosan can be easily processed into membranes,
gels, nanofibers, beads, nanoparticles, scaffolds, and sponges forms and can be
used in drug delivery systems. Here, we review the bioproperties of chitosan and
report the progress of application of chitosan as membranes in GTR and guided bone
regeneration (GBR), which indicates that chitosan could be a good substrate
candidate as the materials for the GTR/GBR membranes. (c) 2012 Wiley Periodicals,
Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
AN - rayyan-563562357
AU - Xu, C.
AU - Lei, C.
AU - Meng, L. Y.
AU - Wang, C. N.
AU - Song, Y. L.
DO - 10.1002/jbm.b.32662
IS - 5
PY - 2012
SN - ["1552-4973", "1552-4981"]
SP - 1435-1443
ST - Chitosan as a barrier membrane material in periodontal tissue regeneration
TI - Chitosan as a barrier membrane material in periodontal tissue regeneration
VL - 100
Y2 - 7
ID - 15731
ER -
TY - JOUR
AN - rayyan-563561930
AU - Xu, C.
AU - Lei, C.
AU - Meng, L.
AU - Wang, C.
AU - Song, Y.
DO - 10.1002/jbm.b.32662
IS - 5
PY - 2012
SP - 1435-1443
ST - Chitosan as a barrier membrane material in periodontal tissue regeneration
TI - Chitosan as a barrier membrane material in periodontal tissue regeneration
84862780698&doi=10.1002%2fjbm.b.32662&partnerID=40&md5=e7df8dd5535ef5b8ddf08fab59e9
b49c
VL - 100
ID - 15304
ER -
TY - JOUR
AB - Aims: To evaluate the in vitro and in vivo effectiveness of egg yolk
immunoglobulin (IgY) against periodontal disease-causing Fusobacterium nucleatum.
Methods and Results: Four White Leghorn hens (120 days old) were immunized with
whole Fus. nucleatum cells killed with 1% formaldehyde using three injections
provided at 2-week intervals. IgY was produced from egg yolks obtained from these
immunized hens using water dilution, two-step salt precipitation and
ultrafiltration. This IgY was shown to have a purity of 86·8% based on its optical
intensity in the stained SDS-PAGE bands. An enzyme-linked immunosorbent assay
indicated a high specificity for the IgY against Fus. nucleatum with a maximum
antibody titre of 80 000. The IgY had only weak cross-reactivity with Porphyromonas
gingivalis, Prevotella intermedia and Solobacterium moorei. Growth and biofilm
formation by Fus. nucleatum were inhibited by IgY at concentrations of 10 and 20 mg
ml-1. Immunofluorescence and immunoelectron microscope assays revealed a high
binding ability of specific IgY, which may explain the in vitro effectiveness of
IgY. In an in vivo study, IgY treatment resulted in a marked decrease in alveolar
bone loss after Fus. nucleatum infection in a mouse model confirming the
effectiveness of IgY against periodontal disease-causing Fus. nucleatum.
Conclusions: IgY effectively inhibited growth and biofilm formation by Fus.
nucleatum and prevented the progression of periodontal disease by decreasing
alveolar bone loss. Significance and Impact of the Study: Specific IgY may have
potential for the treatment of periodontal disease. © 2012 The Society for Applied
Microbiology.
AN - rayyan-563560569
AU - Xu, F. X.
AU - Xu, Y. P.
AU - Jin, L. J.
AU - Liu, H.
AU - Wang, L. H.
AU - You, J. S.
AU - Li, S. Y.
AU - Li, X. Y.
DO - 10.1111/j.1365-2672.2012.05396.x
IS - 4
KW - formaldehyde
immunoglobulin Y
alveolar bone loss
animal experiment
animal model
antibody titer
article
bacterial growth
bacterial infection
biofilm
cell killing
controlled study
cross reaction
dilution
Fusobacterium nucleatum infection
immunization
immunoelectron microscopy
immunofluorescence
in vitro study
in vivo study
mouse
nonhuman
periodontal disease
precipitation
Solobacterium moorei
ultrafiltration
LA - English
PY - 2012
SN - ["1365-2672", "1364-5072"]
SP - 983-991
ST - Effectiveness of egg yolk immunoglobulin (IgY) against periodontal disease-
causing Fusobacterium nucleatum
TI - Effectiveness of egg yolk immunoglobulin (IgY) against periodontal disease-
causing Fusobacterium nucleatum
VL - 113
ID - 13943
ER -
TY - JOUR
AB - During mechanical force-induced alveolar bone remodeling, macrophage-mediated
local inflammation plays a critical role. Yet, the detailed heterogeneity of
macrophages is still unknown. Single-cell RNA sequencing was used to study the
transcriptome heterogeneity of macrophages during alveolar bone remodeling. We
identified macrophage subclusters with specific gene expression profiles and
functions. CellChat and trajectory analysis revealed a central role of the Ccr2
cluster during development, with the CCL signaling pathway playing a crucial role.
We further demonstrated that the Ccr2 cluster modulated bone remodeling associated
inflammation through an NF-κB dependent pathway. Blocking CCR2 could significantly
reduce the Orthodontic tooth movement (OTM) progression. In addition, we confirmed
the variation of CCR2+ macrophages in human periodontal tissues. Our findings
reveal that mechanical force-induced functional shift of the Ccr2 macrophages
cluster mediated by NF-κB pathway, leading to a pro-inflammatory response and bone
remodeling. This macrophage cluster may represent a potential target for the
manipulation of OTM.
AN - rayyan-563559899
AU - Xu, H.
AU - Zhang, S.
AU - Sathe, A. A.
AU - Jin, Z.
AU - Guan, J.
AU - Sun, W.
AU - Xing, C.
AU - Zhang, H.
AU - Yan, B.
DO - 10.3389/fimmu.2022.835986
KW - ABI 7900
flow cytometer
fluorescence activated cell sorter
genetic analyzer
hematology analyzer
membrane filter
micro-CT scanner
microwell plate
orthodontic device
petri dish
scalpel blade
4',6 diamidino 2 phenylindole
ab955
beta actin
buffer
calvasculin
carbon dioxide
CD11b antigen
CD68 antigen
chemokine receptor CCR2
chemokine receptor CCR2 antagonist
collagenase
complementary DNA
cyanine dye 5
fluorescein
formaldehyde
helenalin
ice
interleukin 4
Ki 67 antigen
lipofectamine
lipopolysaccharide
major histocompatibility antigen class 2
messenger RNA
osteopontin
paraformaldehyde
streptomycin
SYBR green
synaptotagmin I
transcriptome
triggering receptor expressed on myeloid cells 2
triton x 100
trypan blue
adult
alveolar bone
animal experiment
animal model
animal tissue
article
bone remodeling
bone tissue
cell culture
cell interaction
cell selection
chemoluminescence
controlled study
curettage
cytolysis
density gradient centrifugation
fetal bovine serum
first premolar
gene control
immunofluorescence
incubation time
light dark cycle
macrophage
male
mitochondrial gene
mouse
NF kB signaling
nonhuman
RNA extraction
RNA sequence
single cell RNA seq
Western blotting
FACSAria
Skyscan 1176
LA - English
PY - 2022
SN - 1664-3224
ST - CCR2+ Macrophages Promote Orthodontic Tooth Movement and Alveolar Bone
Remodeling
TI - CCR2+ Macrophages Promote Orthodontic Tooth Movement and Alveolar Bone
Remodeling
VL - 13
ID - 13273
ER -
TY - JOUR
AB - Infections are the leading cause of failure of osteogenic material
implantation. Antibiotic treatment, treatment with bone cement, or collagen sponge
placement can result in drug resistance and difficulties in operation. To address
this, gellan gum (GG) was selected in this study and prepared as an injectable
hydrogel containing chlorhexidine (CHX) and nanohydroxyapatite (nHA) that overcomes
these intractable problems. Scanning electron microscopy and micro-computed
tomography revealed a three-dimensional polymeric network of the hydrogel. The
hydrogel had excellent biocompatibility, as detected by cell counting kit-8 and
Live/Dead assay. Bone marrow mesenchymal stem cells could be encapsulated into the
network, showing that the structure was suitable for cell growth. Additionally,
loading the hydrogel with nHA improved its mechanical, biodegradable, and
osteogenic properties. Quantitative alkaline phosphatase and Alizarin Red S
staining validated its osteogenic ability. Furthermore, antibacterial activity
assessment showed that the hydrogel loaded with 50 mu g/mL CHX inhibited
Enterococcus faecalis in a concentration-dependent manner. Thus, we report an
injectable GG-based hydrogel with superior antibacterial effect against E. faecalis
and osteogenesis, which holds promise for treating infectious bone defects caused
by refractory periradicular periodontitis. (c) 2020 Elsevier B.V. All rights
reserved.
AN - rayyan-563562339
AU - Xu, L. J.
AU - Bai, X.
AU - Yang, J. J.
AU - Li, J. S.
AU - Xing, J. Q.
AU - Yuan, H.
AU - Xie, J.
AU - Li, J. Y.
DO - 10.1016/j.ijbiomac.2020.10.083
PY - 2020
SN - ["0141-8130", "1879-0003"]
SP - 2964-2973
ST - Preparation and characterisation of a gellan gum-based hydrogel enabling
osteogenesis and inhibiting Enterococcus faecalis
TI - Preparation and characterisation of a gellan gum-based hydrogel enabling
VL - 165
Y2 - 12 y3 - 15
ID - 15713
ER -
TY - JOUR
AB - Infections are the leading cause of failure of osteogenic material
implantation. Antibiotic treatment, treatment with bone cement, or collagen sponge
placement can result in drug resistance and difficulties in operation. To address
this, gellan gum (GG) was selected in this study and prepared as an injectable
hydrogel containing chlorhexidine (CHX) and nanohydroxyapatite (nHA) that overcomes
these intractable problems. Scanning electron microscopy and micro-computed
tomography revealed a three-dimensional polymeric network of the hydrogel. The
hydrogel had excellent biocompatibility, as detected by cell counting kit-8 and
Live/Dead assay. Bone marrow mesenchymal stem cells could be encapsulated into the
network, showing that the structure was suitable for cell growth. Additionally,
loading the hydrogel with nHA improved its mechanical, biodegradable, and
osteogenic properties. Quantitative alkaline phosphatase and Alizarin Red S
staining validated its osteogenic ability. Furthermore, antibacterial activity
assessment showed that the hydrogel loaded with 50 μg/mL CHX inhibited Enterococcus
faecalis in a concentration-dependent manner. Thus, we report an injectable GG-
based hydrogel with superior antibacterial effect against E. faecalis and
osteogenesis, which holds promise for treating infectious bone defects caused by
refractory periradicular periodontitis.
AN - rayyan-563560065
AU - Xu, L.
AU - Bai, X.
AU - Yang, J.
AU - Li, J.
AU - Xing, J.
AU - Yuan, H.
AU - Xie, J.
DO - 10.1016/j.ijbiomac.2020.10.083
chlorhexidine
gellan
hydrogel
nanohydroxyapatite
Alizarin Red S staining
animal cell
animal experiment
animal model
animal tissue
article
biocompatibility
biodegradation
biomechanics
bone development
cell culture
cell growth
cell viability
chemical structure
controlled study
encapsulation
flow kinetics
male
mechanical test
nonhuman
osteocyte
periodontitis
physical chemistry
rat
staining
X ray diffraction
LA - English
PY - 2020
SN - ["1879-0003", "0141-8130"]
SP - 2964-2973
ST - Preparation and characterisation of a gellan gum-based hydrogel enabling
TI - Preparation and characterisation of a gellan gum-based hydrogel enabling
VL - 165
ID - 13439
ER -
TY - JOUR
AB - Periodontitis and hypertension often occur as comorbidities, which need to be
treated at the same time. To resolve this issue, a controlled-release composite
hydrogel approach is proposed with dual antibacterial and anti-inflammatory
activities as a resolution to achieve the goal of co-treatment of comorbidities.
Specifically, chitosan (CS) with inherent antibacterial properties is cross-linked
with antimicrobial peptide (AMP)-modified polyethylene glycol (PEG) to form a dual
antibacterial hydrogel (CS-PA). Subsequently, curcumin loaded into biodegradable
nanoparticles (CNP) are embedded in the hydrogel exhibiting high encapsulation
efficiency and sustained release to achieve long-term anti-inflammatory activities.
In a mouse model of periodontitis complicated with hypertension, CS-PA/CNP is
applied to gingival sulcus and produced an optimal therapeutic effect on
periodontitis and hypertension simultaneously. The therapeutic mechanisms are
deeply studied and indicated that CS-PA/CNP exerted excellent immunoregulatory
effects by suppressing the accumulation of lymphocytes and myeloid cells and
enhanced the antioxidant capacity and thus the anti-inflammatory capacity of
macrophages through the glutathione metabolism pathway. In conclusion, CS-PA/CNP
has demonstrated its superior therapeutic effects and potential clinical
translational value in the co-treatment of periodontitis and hypertension, and also
serves as a drug delivery platform to provide combinatorial therapeutic options for
periodontitis with complicated pathogenesis.
AN - rayyan-563559685
AU - Xu, S.
AU - Hu, B.
AU - Dong, T.
AU - Chen, B. Y.
AU - Xiong, X. J.
AU - Du, L. J.
AU - Li, Y. L.
AU - Chen, Y. L.
AU - Tian, G. C.
AU - Bai, X. B.
AU - Liu, T.
AU - Zhou, L. J.
AU - Zhang, W. C.
AU - Liu, Y.
AU - Ding, Q. F.
AU - Zhang, X. Q.
AU - Duan, S. Z.
DO - 10.1002/adhm.202203337
IS - 20
KW - animal cell
animal experiment
animal model
article
bone marrow cell
comorbidity
complication
controlled study
cross linking
encapsulation
gingiva
glutathione metabolism
human
hypertension
immune dysregulation
inflammation
lymphocyte
macrophage
male
mouse
mouse model
nonhuman
oxidative stress
periodontitis
therapy effect
antiinfective agent
antioxidant
chitosan
curcumin
endogenous compound
hydrogel
macrogol
nanoparticle
LA - English
PY - 2023
SN - ["2192-2659", "2192-2640"]
ST - Alleviate Periodontitis and Its Comorbidity Hypertension using a
Nanoparticle-Embedded Functional Hydrogel System
TI - Alleviate Periodontitis and Its Comorbidity Hypertension using a
Nanoparticle-Embedded Functional Hydrogel System
VL - 12
ID - 13059
ER -
TY - JOUR
AB - According to the US Surgeon General's report, "Oral Health in America,"
published in 2000, most adults in the United States show some degree of periodontal
pathology, with severe periodontal diseases affecting about 14% of middle-aged
adults. Periodontal diseases are polymicrobial-induced inflammatory diseases, and
they vary from mild gingival inflammation to severe deterioration of the
periodontium, ie, loss of periodontal supportive tissues and, ultimately, tooth
loss. New evidence shows that periodontal diseases may impact systemic health. For
this reason, the maintenance of a healthy mouth is becoming increasingly important
for the overall health of the body. This article summarizes laboratory research
conducted during the development of a novel, multibenefit, oral-care technology
based on triclosan--a broad-spectrum antibacterial agent--and a
polyvinylmethylether/maleic acid copolymer. This unique combination of agents is
found in Colgate Total, a clinically proven efficacious dentifrice for control of
dental plaque and gingivitis. Data are presented that demonstrate the unique
antibacterial properties of this dentifrice: (1) a broad-spectrum antimicrobial
profile; (2) the long-lasting retention of triclosan on hydroxyapatite and
epithelial cells; and (3) molecular evidence of antibacterial activity against
specific pathogens in clinical dental plaque. In addition, data are presented that
demonstrate the anti-inflammatory effects of triclosan on specific cytokines, the
interruption of inflammatory pathways, and the inhibition of bone resorption.
Overall, these data support the multibenefit clinical effects of Colgate Total and
suggest a plurality of mechanisms of action.
AN - rayyan-563561408
AU - Xu, T.
AU - Deshmukh, M.
AU - Barnes, V. M.
AU - Trivedi, H. M.
AU - Cummins, D.
IS - 7
J2 - Compend Contin Educ Dent
Adult
Animals
Anti-Infective Agents, Local/pharmacology/*therapeutic use
Complex Mixtures
Dental Plaque/microbiology/*prevention & control
Dentifrices/pharmacology/*therapeutic use
Fluorides
Fusobacterium nucleatum/drug effects
Humans
Inflammation Mediators/*antagonists & inhibitors
Lacticaseibacillus casei/drug effects
Silicic Acid
Toothpastes
Triclosan
LA - eng
N1 - The Colgate-Palmolive Company, Technology Center, Piscataway, New Jersey,
USA.
PY - 2004
SN - 1548-8578 (Print)
SP - 46-53
ST - Effectiveness of a triclosan/copolymer dentifrice on microbiological and
inflammatory parameters
T2 - Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
TI - Effectiveness of a triclosan/copolymer dentifrice on microbiological and
inflammatory parameters
VL - 25
Y2 - 7
ID - 14782
ER -
TY - COMP
AB - OBJECTIVE: This study analyzed, from a combined clinical and molecular
biologic perspective, the antibacterial and antiplaque efficacy of Colgate Total
dentifrice (CTD). METHODOLOGY: A single-blind crossover study design utilized 11
healthy human subjects. After a one-week washout period, subjects donated dental
plaque, received a dental prophylaxis, and subsequently brushed with a test
product. Twenty-four hours postbrushing, dental plaque was collected and a clinical
plaque score determined. Dental plaque was submitted for Real-time Polymerase Chain
Reaction (Real-time PCR) analysis. The same procedure was repeated in accordance
with a crossover design for the use of the second test product. Following a one-
week washout, a plaque donation, prophylaxis, and brushing with the test product
ensued for each subject. Twenty-four hours post-brushing, the subjects returned for
a plaque score and plaque donation. RESULTS: Twenty-four hours after brushing,
dental plaque coverage increased 17.88% +/- 8.27% with CTD, compared to 30.42% +/-
9.97% with Colgate Cavity Protection (CCP; p = 0.005). Real-time PCR found plaque
collected 24 hours after brushing with CTD exhibited, on average, fewer
representative periodontal pathogens (Fusobacterium nucleatum, Actinobacillus
actinomycetemcomitans, Tannerella forsythensis, and Porphyromonas gingivalis) and
fewer early colonizers (Actinomyces naeslundii) than plaque collected before
brushing, whereas CCP showed a moderate effect on oral bacteria. CONCLUSION: The
study provides clinical and molecular biological evidence to substantiate the
antibacterial and plaque control benefits of Colgate Total, and suggests the value
of combining a molecular biological method with clinical research to corroborate
clinical benefits.
AN - rayyan-563561347
AU - Xu, T.
AU - Deshmukh, M.
AU - Barnes, V. M.
AU - Trivedi, H. M.
AU - Du-Thumm, L.
AU - Richter, R.
AU - Cummins, D.
CY - United States
ET - 4
J2 - J Clin Dent
Complex Mixtures/therapeutic use
Cross-Over Studies
Dental Plaque/microbiology/*prevention & control
Dental Plaque Index
Dentifrices/*therapeutic use
Eubacterium/drug effects
Fluorides/therapeutic use
Follow-Up Studies
Fusobacterium nucleatum/drug effects
Humans
Polymerase Chain Reaction/methods
Silicic Acid
Silicon Dioxide/therapeutic use
Single-Blind Method
Sodium Fluoride/therapeutic use
Toothpastes/therapeutic use
Triclosan/therapeutic use
LA - eng
N1 - Colgate-Palmolive Technology Center Piscataway, NJ, USA. tao_xu@colpal.com
PY - 2005
SN - 0895-8831 (Print)
SP - 117-22
ST - Analysis of the antibacterial activity and plaque control benefit of colgate
total dentifrice via clinical evaluation and real-time polymerase chain reaction
TI - Analysis of the antibacterial activity and plaque control benefit of colgate
total dentifrice via clinical evaluation and real-time polymerase chain reaction
VL - 16
ID - 14721
ER -
TY - JOUR
AB - Periodontitis is a bacterial infectious disease leading to the loss of
periodontal supporting tissues and teeth. The current guided tissue regeneration
(GTR) membranes for periodontitis treatments cannot effectively promote tissue
regeneration for the limited antibacterial properties and the excessively fast
degradation rate. Besides, they need extra tailoring according to variform defects
before implantation, leading to imprecise match. This study proposed an injectable
sodium alginate hydrogel composite (CTP-SA) doped with cubic cuprous oxide (Cu2O)
and polydopamine-coated titanium dioxide (TiO2@PDA) nanoparticles for GTR. Inspired
by the gelation process of the jelly, the phase change (liquid to solid) of CTP-SA
after injection could automatch variform bone defects. Meanwhile, CTP-SA exhibited
broad-spectrum antibacterial capabilities under blue light (BL) irradiation,
including Streptococcus mutans (one of the most abundant bacteria in oral
biofilms). Moreover, the reactive oxygen species released under BL excitation could
accelerate the oxidation of Cu+ to Cu2+. Afterward, osteogenesis could be enhanced
through two factors simultaneously: the stimulation of newly formed Cu2+ and the
photothermal effect of CTP-SA under near-infrared (NIR) irradiation. Collectively,
through this dual-light (blue and NIR) noninvasive regulation, CTP-SA could switch
antibacterial and osteogenic modes to address requirements of patients at different
healing stages, thereby realizing the customized GTR procedures.
AN - rayyan-563562235
AU - Xu, Y. Y.
AU - Zhao, S. Y.
AU - Weng, Z. Z.
AU - Zhang, W.
AU - Wan, X. Y.
AU - Cui, T. C.
AU - Ye, J.
AU - Liao, L.
AU - Wang, X. L.
DO - 10.1021/acsami.0c18070
IS - 49
PY - 2020
SN - ["1944-8244", "1944-8252"]
SP - 54497-54506
ST - Jelly-Inspired Injectable Guided Tissue Regeneration Strategy with Shape
Auto-Matched and Dual-Light-Defined Antibacterial/Osteogenic Pattern Switch
Properties
TI - Jelly-Inspired Injectable Guided Tissue Regeneration Strategy with Shape
Properties
VL - 12
Y2 - 12 y3 - 9
ID - 15609
ER -
TY - JOUR
AB - Periodontitis is a bacterial infectious disease leading to the loss of
periodontal supporting tissues and teeth. The current guided tissue regeneration
(GTR) membranes for periodontitis treatments cannot effectively promote tissue
regeneration for the limited antibacterial properties and the excessively fast
degradation rate. Besides, they need extra tailoring according to variform defects
before implantation, leading to imprecise match. This study proposed an injectable
sodium alginate hydrogel composite (CTP-SA) doped with cubic cuprous oxide (Cu2O)
and polydopamine-coated titanium dioxide (TiO2@PDA) nanoparticles for GTR. Inspired
by the gelation process of the jelly, the phase change (liquid to solid) of CTP-SA
after injection could automatch variform bone defects. Meanwhile, CTP-SA exhibited
broad-spectrum antibacterial capabilities under blue light (BL) irradiation,
including Streptococcus mutans (one of the most abundant bacteria in oral
biofilms). Moreover, the reactive oxygen species released under BL excitation could
accelerate the oxidation of Cu+ to Cu2+. Afterward, osteogenesis could be enhanced
through two factors simultaneously: the stimulation of newly formed Cu2+ and the
photothermal effect of CTP-SA under near-infrared (NIR) irradiation. Collectively,
through this dual-light (blue and NIR) noninvasive regulation, CTP-SA could switch
antibacterial and osteogenic modes to address requirements of patients at different
healing stages, thereby realizing the customized GTR procedures.
AN - rayyan-563560066
AU - Xu, Y.
AU - Zhao, S.
AU - Weng, Z.
AU - Zhang, W.
AU - Wan, X.
AU - Cui, T.
AU - Ye, J.
AU - Liao, L.
AU - Wang, X.
DO - 10.1021/acsami.0c18070
IS - 49
KW - alginic acid
antiinfective agent
biomaterial
copper
cuprous oxide
indole derivative
nanoparticle
polydopamine
polymer
titanium
titanium dioxide
animal
biofilm
bone development
bone regeneration
chemistry
cytology
drug effect
hydrogel
infrared radiation
light
metabolism
physiology
rat
Sprague Dawley rat
LA - English
PY - 2020
SN - 1944-8252
SP - 54497-54506
ST - Jelly-Inspired Injectable Guided Tissue Regeneration Strategy with Shape
Properties
TI - Jelly-Inspired Injectable Guided Tissue Regeneration Strategy with Shape
Properties
VL - 12
ID - 13440
ER -
TY - JOUR
AB - Periodontal disease is an infection-driven inflammatory disease characterized
by the destruction of tooth-supporting tissues. The establishment of chronic
inflammation will result in progressive destruction of bone and soft tissue
changes. Severe periodontitis can lead to tooth loss. The disease has complex
pathogenesis with an interplay between genetic, environmental, and host factors and
pathogens. Effective management consists of plaque control and non-surgical
interventions, along with adjuvant strategies to control inflammation and disrupt
the pathogenic subgingival biofilms. Recent studies have examined novel approaches
for managing periodontal diseases such as modulating microbial signaling
mechanisms, tissue engineering, and molecular targeting of host inflammatory
substances. Mounting evidence suggests the need to integrate omics-based approaches
with traditional therapy to address the disease. This article discusses the various
evolving and future drug targets, including proteomics, gene therapeutics,
vaccines, and nanotechnology in personalized periodontal medicine for the effective
management of periodontal diseases.
AN - rayyan-563559895
AU - Yadalam, P. K.
AU - Kalaivani, V.
AU - Fageeh, H. I.
AU - Ibraheem, W.
AU - Al-Ahmari, M. M.
AU - Khan, S. S.
AU - Ahmed, Z. H.
AU - Abdulkarim, H. H.
AU - Baeshen, H. A.
AU - Balaji, T. M.
AU - Bhandi, S.
AU - Raj, A. T.
AU - Patil, S.
DO - 10.3390/jpm12030371
IS - 3
KW - 1 [5 carbamoyl 6 (2,4 difluorophenyl) 2 pyridinyl] 1 (2,6 difluorophenyl)urea
4 (2 aminoethylamino) 1,8 dimethylimidazo[1,2 a]quinoxaline
acalabrutnib
aciclovir
aw 814141
Bruton tyrosine kinase
Bruton tyrosine kinase inhibitor
calgranulin A
calgranulin B
carrageenan
chitin
chlorhexidine
collagen
cyclooxygenase 2
cystatin SA
cytokine
dextro tyrosylisoleucylcysteinylvalyl 1
methyltryptophylglutaminylaspartyltryptophyl n
methylglycylalanylhistidylarginylcysteinyl n methylisoleucinamide 3,13 cyclic
sulfide
doramapimod
doxycycline
fibrinogen
fr 180204
glycosaminoglycan
hemagglutinin
histatin
host factor
hydrogel
hydroxyapatite
immunoglobulin A antibody
interleukin 6
metronidazole
minocycline
mitogen activated protein kinase p38 inhibitor
nanocomposite
nanofiber
neflamapimod
nitric oxide
omega 3 fatty acid
phosphoprotein
polycaprolactone
polyglycolic acid
polylactic acid
proline rich phosphoprotein
resveratrol
sb 242235
tetracycline
thioredoxin
tinidazole
triclosan
unclassified drug
vaccine
valaciclovir
vasculotropin
arachidonic acid metabolism
bacteriophage
biofilm
bone destruction
CD4+ T lymphocyte
CD8+ T lymphocyte
cytokine production
Cytomegalovirus
dental procedure
dental root planning
dental scaling
drug targeting
Epstein Barr virus
fibroblast
gene therapy
gingiva
helper cell
heredity
Herpesviridae
human
immune response
JAK-STAT signaling
memory B lymphocyte
nanotechnology
neutrophil
nonhuman
omics
osteoclast
osteolysis
passive immunization
periodontal disease
periodontitis
periodontium
personalized medicine
proteomics
review
systematic review
tissue engineering
tooth plaque
Treponema denticola
virus load
Yersinia pestis
valtrex
LA - English
PY - 2022
SN - 2075-4426
ST - Future Drug Targets in Periodontal Personalised Medicine—A Narrative Review
T2 - J. Pers. Med.
TI - Future Drug Targets in Periodontal Personalised Medicine—A Narrative Review
VL - 12
ID - 13269
ER -
TY - JOUR
AB - Plantaricin LD1 was purified to homogeneity using activity-guided
chromatography. Enterococcus faecalis ATCC 29212 was found to be sensitive to
plantaricin LD1 showing 13 ± 0·21 mm zone of growth inhibition. The minimum
inhibitory concentration (MIC) was found to be 50 µg ml−1 against Ent. faecalis
ATCC 29212. The in vitro biofilm formation by Ent. faecalis ATCC 29212 was
observed, which was completely inhibited in the presence of bacteriocin. Similarly,
biofilm formation was also observed on the teeth surface showing purple colour,
whereas treated-teeth were clean and indicated no biofilm formation. Further,
untreated cells of Ent. faecalis ATCC 29212 were found normal and plantaricin LD1-
treated cells were ruptured when seen under light microscope, suggesting killing of
target cells. These findings have proven the initial leads for antimicrobial and
anti-biofilm activity of plantaricin LD1 against Ent. faecalis and its possible
application for the treatment of endodontic diseases.
AN - rayyan-563559805
AU - Yadav, M. K.
AU - Yadav, P.
AU - Dhiman, M.
AU - Tewari, S.
AU - Tiwari, S. K.
DO - 10.1111/lam.13668
IS - 3
KW - membrane filter
microplate
microscope
agar
antibiotic agent
antiinfective agent
bacteriocin
chlorhexidine
drug
hypochlorite sodium
methanol
nisin
protein
sephadex
yeast extract
article
biofilm
chromatography
controlled study
growth inhibition
in vitro study
mouth infection
nonhuman
periodontal disease
pulpitis
target cell
tissue injury
tooth
tooth pulp disease
LA - English
PY - 2022
SN - ["1472-765X", "0266-8254"]
SP - 623-631
ST - Plantaricin LD1 purified from Lactobacillus plantarum LD1 inhibits biofilm
formation of Enterococcus faecalis ATCC 29212 in tooth model
T2 - Lett. Appl. Microbiol.
TI - Plantaricin LD1 purified from Lactobacillus plantarum LD1 inhibits biofilm
formation of Enterococcus faecalis ATCC 29212 in tooth model
VL - 75
ID - 13179
ER -
TY - JOUR
AB - Background: Periodontitis is a microbial disease that leads to inflammation
in the tooth-supporting tissues of the oral cavity that is common among the
elderly. It is initiated by oral inflammation induced by bacterial dysbiosis.
Choosing an appropriate antimicrobial agent with the right course of drug
administration is the key to successful periodontal therapy. In recent times, with
more biomarkers and the development of new technologies, several point-of-care
testing (POCT) platforms have been developed for the diagnosis and monitoring of
periodontitis. This review focuses on oral microbiology and the pathogenesis of
periodontitis as well as recent insights into the in situ gel system for
periodontitis. Design: An exhaustive search was conducted in the following
scientific databases Science Direct, Springer, Pub Med, and Google Scholar to
review all relevant literatures. This is a comprehensive narrative review of the
literature, summarizing the perspectives of the authors. Results: Novel in situ
forming gel is introduced at the site that shows a promising potential to overcome
one of the main practical obstacles associated with the treatment of local
periodontitis: partial adhesion to the surrounding tissue, causing in the
accidental expulsion of at least parts of the implants from patient’s pockets. This
results in a large residence time of the system at the site of action and
uncertainty of the final exposure to the drug. Conclusion: From the reviewed
literature, it is concluded that experimental evidence suggests that the in situ
gel-forming systems can be useful in treating several common diseases of the oral
cavity. Future research should focus on clinical studies to be performed for the in
situ gel to make a significant contribution to periodontitis. Graphical abstract:
[Figure not available: see fulltext.]
AN - rayyan-563560068
AU - Yadav, R.
AU - Kanwar, I. L.
AU - Haider, T.
AU - Pandey, V.
AU - Gour, V.
AU - Soni, V.
DO - 10.1186/s43094-020-00053-x
IS - 1
biological marker
diagnostic agent
gel
polymer
critical solution temperature
drug release
dysbiosis
gelation
human
ionic strength
mouth cavity
mouth flora
nonhuman
pathogenesis
periodontal pocket
periodontitis
pH
point of care testing
polymerization
review
LA - English
PY - 2020
SN - 2314-7245
ST - In situ gel drug delivery system for periodontitis: an insight review
T2 - Future J. Pharm. Sci.
TI - In situ gel drug delivery system for periodontitis: an insight review
VL - 6
ID - 13442
ER -
TY - JOUR
AB - Considering alarming projections in the prevalence of periodontitis,
following study was undertaken to develop chitosan-vanillin crosslinked
microspheres loaded in-situ gel (MLIG) implants containing ornidazole and
doxycycline hyclate for the treatment of pocket infections. Firstly, microspheres
were formulated and optimized using response surface methodology for particle size
<50 μm, entrapment efficiency >80%, in-vitro drug release (T80%) >7 days and
acceptable mucoadhesion. Further, MLIG were optimized for gelation temperature of
34–37 °C and viscosity <1000 cps respectively. FTIR, DSC and XRD graphs disclosed
compatibility and alterations in crystallinity of drugs. In-vitro dissolution study
demonstrated non-Fickian type of drug release mechanism for twelve days. Stability
studies ascertained MLIG implants were sterilizable and stable for about 11.29
months on refrigeration. The formulations exhibited significant (p < 0.001)
antimicrobial activity against Staphylococcus aureus, Escherichia coli, and
Enterococcus faecalis, and were found biocompatible and biodegradable during
preclinical studies. Ligature-induced periodontal rat model, corroborated
significant growth (p < 0.05) of gingival tissue after two weeks. Clinical trials
revealed, intra-pocket administration of MLIG along with SRP provided significant
reduction in clinical parameters as compared to SRP alone. Conclusively,
antimicrobials incorporated thermosensitive, biodegradable, mucoadhesive and
syringeable MLIG implants appeared as better option for the treatment of
periodontitis.
AN - rayyan-563560242
AU - Yadav, S. K.
AU - Khan, G.
AU - Bansal, M.
AU - Thokala, S.
AU - Bonde, G. V.
AU - Upadhyay, M.
AU - Mishra, B.
DO - 10.1016/j.ijbiomac.2018.04.179
KW - orthodontic ligature
doxycycline hyclate
microsphere
ornidazole
adult
animal experiment
animal model
animal tissue
article
controlled study
crystal
drug release
drug solubility
drug stability
Escherichia coli
female
gel
gelation
heat sensitivity
human
in situ gel
in vitro study
male
mucoadhesion
nonhuman
particle size
periodontal pocket
rat
refrigeration
viscosity
LA - English
PY - 2018
SN - ["1879-0003", "0141-8130"]
SP - 394-408
ST - Multiparticulate based thermosensitive intra-pocket forming implants for
better treatment of bacterial infections in periodontitis
TI - Multiparticulate based thermosensitive intra-pocket forming implants for
better treatment of bacterial infections in periodontitis
VL - 116
ID - 13616
ER -
TY - JOUR
AB - Periodontal disease is chronic, highly prevalent infectious disease that
requires prolonged and controlled delivery of antimicrobial agents into pockets. To
achieve this objective, dual antimicrobials encapsulated chitosan fortified calcium
alginate (CS-Ca-SA) microspheres were formulated by application of Plackett-Burman
factorial design. The microspheres were optimized for particle size (PS),
entrapment efficiency (EE) and drug release. The optimized microspheres presented
average PS of 74-461 mu m and EE of 62.45-86.20% with controlled drug delivery for
120 hours. FTIR disclosed successful complexation between SA and CS. DSC and XRD
studies showed changes in the crystallinity of drugs in microspheres. Shape factor
and SEM demonstrated spherical to pear-shaped microspheres. Release exponent >0.43
and high diffusion coefficients revealed non-Fickian-based diffusion-limited drug
release. CS-Ca-SA microspheres exhibited surface pH of 6.5 +/- 0.5, moderate
swelling, less erosion and improved mucoadhesion over Ca-SA microspheres. Also,
significant antimicrobial activity against Escherichia coli and Staphylococcus
aureus and cytocompatibility with L929 cell lines were observed. Further,
microspheres exhibited long-term stability on refrigeration. The outcomes of study
supported the potential of dual polymer and dual drug-based biodegradable, stable,
non-toxic, mucoadhesive, controlled and prolonged drug release microspheres as more
patient compliant by administration into periodontal pockets for the management of
AN - rayyan-563562527
AU - Yadav, S. K.
AU - Khan, G.
AU - Bonde, G. V.
AU - Bansal, M.
AU - Mishra, B.
DO - 10.1080/21691401.2017.1366331
IS - 6
PY - 2018
SN - ["2169-1401", "2169-141X"]
SP - 1180-1193
ST - Design, optimization and characterizations of chitosan fortified calcium
alginate microspheres for the controlled delivery of dual drugs
T2 - ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
TI - Design, optimization and characterizations of chitosan fortified calcium
alginate microspheres for the controlled delivery of dual drugs
VL - 46
ID - 15901
ER -
TY - JOUR
AB - Increased prevalence of oral diseases such as gingivitis, periodontitis and
dental caries has become major health issue worldwide. Such growing incidence of
periodontitis has directly affected the development of drug delivery systems and
growth of the market. Since the infections are limited to periodontal pockets or
oral cavity, localized intrapocket drug delivery will be more beneficial than
conventional systemic administration. Advances in intrapocket technology and
innovations in the field of periodontal drug delivery led to increased patent
applications. Newer trends like use of mucoadhesive polymers, in situ forming gels,
viscosity modifiers, plasticizers etc which can enhance intrapocket retention of
drugs have gained considerable attention among researchers and industrialists.
Current market is flooded with products such as Periostat, Periochip®, Atridox®,
Arestin®, Actisite®, Dentomycin®, and Elyzol® and generics such as metronidazole,
levofloxacin, tetracycline, doxycyline and minocycline for intrapocket delivery.
There is a need of novel drugs and delivery systems with better efficacy profiles
than the existing compounds. Inclusion of novel technologies like films, fibers, in
situ forming implants, microparticles, nanoparticles, and liposomes as intrapocket
drug delivery has great potential. Development of antibiotic free drug delivery
such as antiseptics, host modulators, biofilms inhibitors and antibodies has
promising role in the improvement of pathogenesis of periodontitis. Further, this
review deals with various innovations in drug delivery and patents related to
localized intrapocket administration of medicaments in the implications of
periodontitis.
AN - rayyan-563560380
AU - Yadav, S. K.
AU - Khan, G.
AU - Mishra, B.
DO - 10.2174/1872211309666150311095424
IS - 2
antiinfective agent
azithromycin
chlo site
clindamycin
cyclooxygenase 2
minocycline
doxycycline
doxycycline hyclate
erythromycin
interleukin 10
levofloxacin
liposome
listerine
macrophage derived chemokine
metronidazole
mouthwash
nanoparticle
osteocalcin
spiramycin
tetracycline
unclassified drug
article
chewing gum
dental caries
gel
gingivitis
human
ointment
paste
patent
periodontitis
prevalence
priority journal
signal transduction
actisite
arestin
atridox
dentomycin
elyzol
peridex
periochip
periostat
LA - English
PY - 2015
SN - 1872-2113
SP - 129-145
ST - Advances in patents related to intrapocket technology for the management of
periodontitis
TI - Advances in patents related to intrapocket technology for the management of
periodontitis
VL - 9
ID - 13754
ER -
TY - JOUR
AB - Objective: Recent advances in the field of alternative medicine introduced
various herbal products for the treatment of periodontitis. The purpose of this
study was to evaluate the effects of combined extracts from Quercus brantii and
Coriandrum sativum on periodontal indices in adult periodontitis patients. Methods:
In this randomized, double-blinded clinical trial, performed in Isfahan Dental
School in 2012, a new herbal medicament containing combined extracts from Q.
brantii and C. sativum was formulated in the gel form for subgingival application.
Following scaling and root planing (SRP), both herbal and placebo gels were
delivered at the experimental and control sites, respectively. Periodontal pocket
depth, clinical attachment level, papilla bleeding index, and plaque index were
measured at baseline, 1 month and 3 months later. Both intra-and inter-groups
changes were registered. The obtained data were analyzed by SPSS software, using
repeated measure analysis of variance, paired t-test, Mann-Whitney, Friedman, and
Wilcoxon tests. Differences with P < 0.05 were considered to be significant.
Findings: Both groups indicated statistically significant improvements in the
periodontal indices (P < 0.05), but there were no significant differences between
two study groups with this regard. Conclusion: The herbal gel does not have
considerable advantages over SRP alone as an adjunct in periodontal treatment.
AN - rayyan-563560446
AU - Yaghini, J.
AU - Shahabooei, M.
AU - Aslani, A.
AU - Zadeh, M. R.
AU - Kiani, S.
AU - Naghsh, N.
DO - 10.4103/2279-042X.137076
IS - 2
KW - alcohol
Coriandrum sativum extract
plant extract
Quercus brantii extract
unclassified drug
adult
article
software
controlled study
coriander
dental floss
digestive tract parameters
drug efficacy
gel
human
papilla bleeding index
periodontal pocket
plaque index
priority journal
Quercus brantii
ultrasound scanner
Mectron_Carasco
LA - English
PY - 2014
SN - ["2279-042X", "2319-9644"]
SP - 67-71
ST - Efficacy of a local-drug delivery gel containing extracts of Quercus brantii
and Coriandrum sativum as an adjunct to scaling and root planing in moderate
T2 - J. Res. Pharm. Pract.
TI - Efficacy of a local-drug delivery gel containing extracts of Quercus brantii
and Coriandrum sativum as an adjunct to scaling and root planing in moderate
VL - 3
ID - 13820
ER -
TY - JOUR
AB - Background: Periodontitis is caused by a dysbiotic shift in the dental plaque
microbiome. Fusobacterium nucleatum is involved in the colonization of
Porphyromonas gingivalis, which plays a key role in dysbiosis, via coaggregation
and synergy with this microorganism. Aim: We investigated the effect of diffusible
signaling molecules from P. gingivalis ATCC 33277 on F. nucleatum TDC 100 to
elucidate the synergistic mechanisms involved in dysbiosis. Methods: The two
species were cocultured separated with an 0.4-µm membrane in tryptic soy broth, and
F. nucleatum gene expression profiles in coculture with P. gingivalis were compared
with those in monoculture. Results: RNA sequencing revealed 139 genes
differentially expressed between the coculture and monoculture. The expression of
52 genes was upregulated, including the coaggregation ligand-coding gene. Eighty-
seven genes were downregulated. Gene Ontology analysis indicated enrichment for the
glycogen synthesis pathway and a decrease in de novo synthesis of purine and
pyrimidine. Conclusion: These results indicate that diffusible signaling molecules
from P. gingivalis induce metabolic changes in F. nucleatum, including an increase
in polysaccharide synthesis and reduction in de novo synthesis of purine and
pyrimidine. The metabolic changes may accelerate biofilm formation by F. nucleatum
with P. gingivalis. Further, the alterations may represent potential therapeutic
targets for preventing dysbiosis.
AN - rayyan-563559761
AU - Yamaguchi-Kuroda, Y.
AU - Kikuchi, Y.
AU - Kokubu, E.
AU - Ishihara, K.
DO - 10.1080/20002297.2023.2165001
IS - 1
nucleic acid library preparation kit
tryptic soy broth
crystal violet
hemin
menadione
polystyrene
article
bacterial strain
biofilm
coculture
controlled study
differential gene expression
dysbiosis
false discovery rate
gene expression
gene ontology
gene sequence
glycogen synthesis
nonhuman
periodontitis
protein expression
purine synthesis
RNA extraction
RNA sequencing
signal transduction
tooth plaque
HiSeq 2500
TruSeq
LA - English
PY - 2023
SN - 2000-2297
ST - Porphyromonas gingivalis diffusible signaling molecules enhance Fusobacterium
nucleatum biofilm formation via gene expression modulation
T2 - J. Oral Microbiol.
TI - Porphyromonas gingivalis diffusible signaling molecules enhance Fusobacterium
nucleatum biofilm formation via gene expression modulation
VL - 15
ID - 13135
ER -
TY - JOUR
AB - In genome-wide association studies, the CYP2C8 gene locus has been reported
to be associated with bisphosphonate-related osteonecrosis of the jaw, a severe
devastating side effect of antiresorptive bone treatment. The aim of this study was
to elucidate the putative pathomechanism explaining the association between the
genetic polymorphism with the alleles CYP2C8*2 and *3 causing low CYP2C8 activity,
and disturbed periodontal remodelling in periodontal fibroblasts cultured from
patients undergoing orthodontic treatment. CYP2C8 activity, enzyme expression and
substrate metabolism were detected in human periodontal fibroblast cultures.
Zoledronic acid caused enhanced reactive oxygen species (ROS) production in
periodontal fibroblasts, which was enhanced by arachidonic acid as inflammatory
signal. Enhanced bisphosphonate-induced uncoupling of the CYP2C8 enzyme was
detected in the variant allele (CYP2C8*3) with the result of increased H2O2
production and lowered substrate oxidation. Conversely, substrate (amodiaquine)
addition led to decreased H2O2 production in isolated CYP2C8 enzymes, but in
CYP2C8*3 enzyme, increased H2O2 was still detected, especially in presence of
arachidonic acid. CYP2C8 variants leading to decreased enzyme activity in substrate
oxidation may enhance ROS production by reaction uncoupling, and thus, contribute
to difficulties in orthodontic treatment and the risk of side effects of
antiresorptive drugs.
AN - rayyan-563559906
AU - Yamoune, S.
AU - Wintz, K.
AU - Niederau, C.
AU - Craveiro, R. B.
AU - Wolf, M.
AU - Stingl, J.
DO - 10.1111/bcpt.13681
IS - 1
KW - centrifuge
culture medium
filter
FLUOstar
liquid chromatography column
liquid chromatography-mass spectrometer
lysogeny broth medium
microplate reader
microwell plate
Monarch
PCR assay kit
Phusion
QTRAP 6500
V750
acetonitrile
amodiaquine
arachidonic acid
ascorbic acid
biological marker
buffer
calcium
cytochrome P450 2C8
cytochrome P450 2D6
deethylamodiaquine
formic acid
genomic DNA
hydrogen peroxide
Potassium phosphate buffer
primer DNA
reduced nicotinamide adenine dinucleotide phosphate
unclassified drug
zoledronic acid
allele
apoptosis
article
bacterial cell
biocatalysis
biotransformation
bone necrosis
bone remodeling
cell culture
cell isolation
centrifugation
controlled study
Escherichia coli
fetal bovine serum
fibroblast
fluorescence
gene
genome-wide association study
genotype
genotyping
human
human cell
incubation time
nonhuman
oxidation
particle size
periodontium
plasmid
ultrasound
DNeasy
LA - English
PY - 2022
SN - ["1742-7843", "1742-7835"]
SP - 132-140
ST - Role of cytochrome P450 2C8 genetic polymorphism and epoxygenase uncoupling
in periodontal remodelling affecting orthodontic treatment
T2 - Basic Clin. Pharmacol. Toxicol.
TI - Role of cytochrome P450 2C8 genetic polymorphism and epoxygenase uncoupling
in periodontal remodelling affecting orthodontic treatment
VL - 130
ID - 13280
ER -
TY - JOUR
AB - Tooth removal, particularly for patients with severe periodontitis, can
frequently cause massive bleeding, postoperative infection, and bone resorption,
resulting in a dry socket. Thus, developing bio-multifunctional materials with
excellent antibacterial, hemostatic, and osteogenic characteristics for the
prevention of dry sockets after tooth removal is highly desirable in clinical
applications. Herein, chitosan-CaP microflowers (CM) and metronidazole (MD) loaded
calcium alginate (CA) sponges (CA@CM/MD) with enhanced antibacterial, hemostatic,
and osteogenic properties were developed via Ca2+ crosslinking, lyophilization, and
electrostatic interaction for the prevention of dry socket after tooth removal. The
fabricated CM particles display 3 -dimensional, relatively homogeneous, and flower-
shaped architectures. The CA@CM/MD composite sponges were facilely shaped into the
tooth root as well as exhibit interconnected porous and lamellar structures with
remarkable porosity, suitable maximum swelling ratio, as well as excellent
compressive and hemostatic performance. Besides, the in vitro cellular assessment
demonstrates that the prepared CA@CM/MD composite sponges possess satisfactory
cytocompatibility. Importantly, the designed sponges significantly suppress the
growth of S. aureus and E. coli, as well as promote cellular osteogenic
differentiation by upregulating the formation of alkaline phosphatase. Our findings
indicate that the tooth root-shaped composite sponges hold great promise for wound
management after tooth removal.
AN - rayyan-563562471
AU - Yan, M. Z.
AU - Pan, Y. X.
AU - Lu, S. L.
AU - Li, X.
AU - Wang, D. Y.
AU - Shao, T. Y.
AU - Wu, Z. H.
AU - Zhou, Q. H.
DO - 10.1016/j.ijbiomac.2022.05.094
PY - 2022
SN - ["0141-8130", "1879-0003"]
SP - 134-145
ST - Chitosan-CaP microflowers and metronidazole loaded calcium alginate sponges
with enhanced antibacterial, hemostatic and osteogenic properties for the
prevention of dry socket after tooth removal
TI - Chitosan-CaP microflowers and metronidazole loaded calcium alginate sponges
with enhanced antibacterial, hemostatic and osteogenic properties for the
prevention of dry socket after tooth removal
VL - 212
Y2 - 7 y3 - 1
ID - 15845
ER -
TY - JOUR
AB - Periodontitis is a chronic inflammatory disease caused by the interaction of
oral microorganisms with the host immune response. Porphyromonas gingivalis (P.g.)
acts as a key mediator in subverting the homeostasis of the local immune system. On
the one hand, P.g. inhibits phagocytosis and the killing capacity of immune cells.
On the other hand, P.g. increases selective cytokine release, which is beneficial
to its further proliferation. Here, we prepared a penetrating macrophage-based
nanoformulation (MZ@PNM)-encapsulating hydrogel (MZ@PNM@GCP) that responded to the
periodontitis microenvironment. MZ@PNM targeted P.g. via the Toll-like receptor
complex 2/1 (TLR2/1) on its macrophage-mimicking membrane, then directly killed
P.g. through disruption of bacterial structural integrity by the cationic
nanoparticles and intracellular release of an antibacterial drug, metronidazole
(MZ). Meanwhile, MZ@PNM interrupted the specific binding of P.g. to immune cells
and neutralized complement component 5a (C5a), preventing P.g. subversion of
periodontal host immune response. Overall, MZ@PNM@GCP showed potent efficacy in
periodontitis treatment, restoring local immune function and killing pathogenic
bacteria, while exhibiting favorable biocompatibility, all of which have been
demonstrated both in vivo and in vitro.
AN - rayyan-563562200
AU - Yan, N.
AU - Xu, J. C.
AU - Liu, G. L.
AU - Ma, C.
AU - Bao, L.
AU - Cong, Y. L.
AU - Wang, Z. Y.
AU - Zhao, Y. L.
AU - Xu, W. H.
AU - Chen, C. Y.
DO - 10.1021/acsnano.2c05923
IS - 11
PY - 2022
SN - ["1936-0851", "1936-086X"]
SP - 18253-18265
ST - Penetrating Macrophage-Based Nanoformulation for Periodontitis Treatment
T2 - ACS NANO
TI - Penetrating Macrophage-Based Nanoformulation for Periodontitis Treatment
VL - 16
Y2 - 11 y3 - 22
ID - 15574
ER -
TY - JOUR
AB - Periodontitis is a chronic inflammatory disease caused by the interaction of
oral microorganisms with the host immune response. Porphyromonas gingivalis (P.g.)
acts as a key mediator in subverting the homeostasis of the local immune system. On
the one hand, P.g. inhibits phagocytosis and the killing capacity of immune cells.
On the other hand, P.g. increases selective cytokine release, which is beneficial
to its further proliferation. Here, we prepared a penetrating macrophage-based
nanoformulation (MZ@PNM)-encapsulating hydrogel (MZ@PNM@GCP) that responded to the
periodontitis microenvironment. MZ@PNM targeted P.g. via the Toll-like receptor
complex 2/1 (TLR2/1) on its macrophage-mimicking membrane, then directly killed
P.g. through disruption of bacterial structural integrity by the cationic
nanoparticles and intracellular release of an antibacterial drug, metronidazole
(MZ). Meanwhile, MZ@PNM interrupted the specific binding of P.g. to immune cells
and neutralized complement component 5a (C5a), preventing P.g. subversion of
periodontal host immune response. Overall, MZ@PNM@GCP showed potent efficacy in
periodontitis treatment, restoring local immune function and killing pathogenic
bacteria, while exhibiting favorable biocompatibility, all of which have been
demonstrated both in vivo and in vitro.
AN - rayyan-563559791
AU - Yan, N.
AU - Xu, J.
AU - Liu, G.
AU - Ma, C.
AU - Bao, L.
AU - Cong, Y.
AU - Wang, Z.
AU - Zhao, Y.
AU - Xu, W.
AU - Chen, C.
DO - 10.1021/acsnano.2c05923
IS - 11
KW - cytokine
human
macrophage
metabolism
periodontitis
physiology
LA - English
PY - 2022
SN - 1936-086X
SP - 18253-18265
ST - Penetrating Macrophage-Based Nanoformulation for Periodontitis Treatment
T2 - ACS Nano
TI - Penetrating Macrophage-Based Nanoformulation for Periodontitis Treatment
VL - 16
ID - 13165
ER -
TY - JOUR
AB - Introduction. Prader-Willi syndrome is a complex genetic disease caused by
lack of expression of paternally inherited genes on chromosome 15q11-q13. The
prevalence of Prader-Willi syndrome is estimated to be one in 10,000 to 25,000.
However, descriptions of the oral and dental phenotype are rare. Case presentation.
We describe the clinical presentation and periodontal findings in a 20-year-old
Japanese man with previously diagnosed Prader-Willi syndrome. Clinical and
radiographic findings confirmed the diagnosis of periodontitis. The most striking
oral findings were anterior open bite, and crowding and attrition of the lower
first molars. Periodontal treatment consisted of tooth-brushing instruction and
scaling. Home care involved recommended use of adjunctive chlorhexidine gel for
tooth brushing twice a week and chlorhexidine mouthwash twice daily. Gingival
swelling improved, but further treatment will be required and our patient's oral
hygiene remains poor. The present treatment of tooth-brushing instruction and
scaling every three weeks therefore only represents a temporary solution.
Conclusions: Rather than being a direct result of genetic defects, periodontal
diseases in Prader-Willi syndrome may largely result from a loss of cuspid guidance
leading to traumatic occlusion, which in turn leads to the development of
periodontal diseases and dental plaque because of poor oral hygiene. These could be
avoided by early interventions to improve occlusion and regular follow-up to
monitor oral hygiene. This report emphasizes the importance of long-term follow-up
of oral health care by dental practitioners, especially pediatric dentists, to
prevent periodontal disease and dental caries in patients with Prader-Willi
syndrome, who appear to have problems maintaining their own oral health. © 2011
Yanagita et al; licensee BioMed Central Ltd.
AN - rayyan-563560579
AU - Yanagita, M.
AU - Hirano, H.
AU - Kobashi, M.
AU - Nozaki, T.
AU - Yamada, S.
AU - Kitamura, M.
AU - Murakami, S.
DO - 10.1186/1752-1947-5-329
adult
article
body height
body weight
case report
cyanosis
dental caries
genetic screening
gingiva pain
gingivitis
home care
human
hypoplasia
Japanese (people)
low birth weight
male
malocclusion
molar tooth
mouth examination
mouth hygiene
muscle hypotonia
periodontal pocket
periodontitis
Prader Willi syndrome
premolar tooth
priority journal
tooth brushing
tooth disease
tooth radiography
LA - English
PY - 2011
SN - 1752-1947
ST - Periodontal disease in a patient with Prader-Willi syndrome: A case report
T2 - J. Med. Case Rep.
TI - Periodontal disease in a patient with Prader-Willi syndrome: A case report
VL - 5
ID - 13953
ER -
TY - JOUR
AB - OBJECTIVE: This study was designed to evaluate the clinical effects of
metronidazole ofloxacin gel (MO gel) as an adjunct to conventional therapy for
periodontitis. METHODS: 13 patients with adult periodontitis were selected and each
of them had two or more sites with probing depth > or = 4 mm, so totally 35 teeth
were included in this study. After conventional therapy, the subjects were randomly
divided into three groups: (1) experimental group application with MO gel, (2)
standard group application with metronidazole stitus, and (3) control group
application with placebo gel. Local application was performed once a week for 12
weeks. Clinical parameters including PD, PAL, GI, BOP, PLI was recorded after 6
weeks and 12 weeks respectively. RESULTS: All clinical parameters from group of gel
and group of metronidazole stilus were better than that from control group, while
no significant difference was observed between MO gel group and metronidazole
stilus group. CONCLUSION: It indicates local application with MO gel treatment as
an adjunct to conventional therapy may lead to a more advantageous outcome for
periodontitis.
AN - rayyan-563560926
AU - Yang, H.
AU - Wang, X.
AU - Xu, Y.
AU - Zhang, J.
IS - 1
metronidazole
adult
aged
article
female
gel
human
male
middle aged
periodontitis
LA - Chinese
PY - 2001
SN - 1000-1182
SP - 35-37
ST - Clinical effects of metronidazole-ofloxacin gel as an adjunct to conventional
therapy for periodontitis
TI - Clinical effects of metronidazole-ofloxacin gel as an adjunct to conventional
therapy for periodontitis
VL - 19
ID - 14300
ER -
TY - JOUR
AB - Background: In addition to releasing a pool of growth factors during
activation, platelets have many features that indicate their role in the anti-
infective host defense. The antimicrobial activities of platelet-rich plasma (PRP)
and related plasma preparations against periodontal disease-associated bacteria
were evaluated. Methods: Four distinct plasma fractions were extracted in the
formulation used commonly in dentistry and were tested for their antibacterial
properties against three periodontal bacteria: Porphyromonas gingivalis,
Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum. The minimum
inhibitory concentration of each plasma preparation was determined, and in vitro
time-kill assays were used to detect their abilities to inhibit bacterial growth.
Bacterial adhesion interference and the susceptibility of bacterial adherence by
these plasma preparations were also conducted. Results: All plasma preparations can
inhibit bacterial growth, with PRP showing the superior activity. Bacterial growth
inhibition by PRP occurred in the first 24 hours after application in the time-kill
assay. PRP interfered with P. gingivalis and A. actinomycetemcomitans attachment
and enhanced exfoliation of attached P. gingivalis but had no influences on F.
nucleatum bacterial adherence. Conclusions: PRP expressed antibacterial properties,
which may be attributed to platelets possessing additional antimicrobial molecules.
The application of PRP on periodontal surgical sites is advisable because of its
regenerative potential and its antibacterial effects.
AN - rayyan-563562223
AU - Yang, L. C.
AU - Hu, S. W.
AU - Yan, M.
AU - Yang, J. J.
AU - Tsou, S. H.
AU - Lin, Y. Y.
DO - 10.1902/jop.2014.140373
IS - 2
PY - 2015
SN - ["0022-3492", "1943-3670"]
SP - 310-318
ST - Antimicrobial Activity of Platelet-Rich Plasma and Other Plasma Preparations
Against Periodontal Pathogens
TI - Antimicrobial Activity of Platelet-Rich Plasma and Other Plasma Preparations
Against Periodontal Pathogens
VL - 86
Y2 - 2
ID - 15597
ER -
TY - JOUR
AB - OBJECTIVE: To optimize the formulation and study the irritation of
doxycycline hyclate in situ forming sustained release injection. METHODS:
Doxycycline in situ forming gel (DHISFG) was prepared by using biodegradable,
biocompatible PLGA and PLA as materials, and non-toxic NMP as solvent. Orthogonal
design was used to optimize the gel formulation. The in vitro drug release,
rheology and irritation were also studied. RESULTS: The optimal formulation of
DHISFG was PLGA (Mn=10000)-NMP-doxycycline hyclate=25:65:10. The drug release from
the DHISFG was 20% within 2 hours and above 90% after 10 days sustained release.
The in vitro release data fit the first release and Fick diffusion mechanism.
Gingival irritation test of rabbit showed no irritation. CONCLUSION: The developed
DHISFG which is degradable and easy to inject could provide a new sustained release
formulation to relieve the symptoms of periodontal disease such as alveolar bone
absorption and tooth loss. Copyright 2012 by the Chinese Pharmaceutical
Association.
AN - rayyan-563560531
AU - Yang, M. Y.
AU - Liu, Q. X.
AU - Shan, L.
AU - Wang, Y. L.
AU - Fan, Y. Z.
AU - Gao, C. S.
IS - 16
doxycycline hyclate in situ forming gel
polylactic acid
unclassified drug
animal experiment
animal model
article
diffusion
drug formulation
fick diffusion
flow kinetics
gel
gingiva disease
gingiva irritation
in vitro study
in vivo study
nonhuman
Leporidae
LA - Chinese
PY - 2012
SN - 1001-2494
SP - 1313-1317
ST - Preparation and in vivo irritating study of doxycycline hyclate in situ
forming sustained release injection
T2 - Chin. Pharm. J. (China)
TI - Preparation and in vivo irritating study of doxycycline hyclate in situ
forming sustained release injection
VL - 47
ID - 13905
ER -
TY - JOUR
AB - In subgingival plaque biofilms, Fusobacterium nucleatum is closely related to
the occurrence and development of periodontitis. Streptococcus gordonii, as an
accessory pathogen, can coaggregate with periodontal pathogens, facilitating the
subgingival colonization of periodontal pathogens. Studies have shown that F.
nucleatum can coaggregate with S. gordonii and colonize the subgingival plaque.
However, most studies have focused on monocultures or coinfection of species and
the potential impact of coaggregation between the two species on periodontal
interactions to human gingival epithelial cells (hGECs) remains poorly understood.
The present study explored the effect of coaggregation between F. nucleatum and S.
gordonii on subgingival synergistic virulence to hGECs. The results showed that
coaggregation inhibited the adhesion and invasion of F. nucleatum to hGECs compared
with that in the F. nucleatum monoculture and coinfection group. Coaggregation and
coinfection with F. nucleatum both enhanced S. gordonii adhesion to hGECs, but
neither of the two groups affected S. gordonii invasion to hGECs compared with S.
gordonii monoculture. The gene expression levels of TLR2 and TLR4 in hGECs in the
coaggregation group were higher than those in the monoculture groups but lower than
those in the coinfection group. Compared with coinfection, the coaggregation
inhibited apoptosis of hGECs and promoted the secretion of the proinflammatory
cytokines TNF-α and IL-6 by hGECs, showed a synergistic inflammatory effect, while
coaggregation inhibited the secretion of the anti-inflammatory cytokine TGF-β1.
Coaggregation enhanced the phosphorylation of p65, p38, and JNK proteins and
therefore activated the NF-κB and MAPK signaling pathways. Pretreatment with a
pathway antagonist/inhibitor decreased the phosphorylation levels of proteins and
the secretion of TNF-α and IL-6. In conclusion, coaggregation inhibited the
adhesion and invasion of F. nucleatum to hGECs. However, it enhanced the adhesion
of S. gordonii to hGECs. Compared with coinfection, coaggregation inhibited the
apoptosis of hGECs. The coaggregation coordinately promoted the secretion of TNF-α
and IL-6 by hGECs through the TLR/NF-κB and TLR/MAPK signaling pathways while
inhibiting the secretion of TGF-β1, thus aggravating the inflammatory response of
hGECs.
AN - rayyan-563559864
AU - Yang, R.
AU - Liu, T.
AU - Pang, C.
AU - Cai, Y.
AU - Lin, Z.
AU - Guo, L.
AU - Wei, X.
DO - 10.3389/fcimb.2022.879423
confocal microscope
ELISA kit
spectrophotometer
cytokine
interleukin 6
synaptophysin
synaptotagmin I
apoptosis
article
bacterial growth
bacterial strain
biofilm
cell adhesion
cell invasion
cell invasion assay
cell proliferation
cell viability
coculture
coinfection
colony forming unit
confocal microscopy
enzyme activity
epithelium cell
gene expression
gingiva
human
human cell
in vitro study
inflammation
MAPK signaling
monoculture
NF kB signaling
nonhuman
periodontitis
RNA isolation
synergistic effect
TLR signaling
virulence
NanoDrop 2000C
LA - English
PY - 2022
SN - 2235-2988
ST - The Regulatory Effect of Coaggregation Between Fusobacterium nucleatum and
Streptococcus gordonii on the Synergistic Virulence to Human Gingival Epithelial
Cells
TI - The Regulatory Effect of Coaggregation Between Fusobacterium nucleatum and
Streptococcus gordonii on the Synergistic Virulence to Human Gingival Epithelial
Cells
VL - 12
ID - 13238
ER -
TY - JOUR
AB - In the present study, an injectable in situ liquid crystal formulation was
developed for local delivery of minocycline hydrochloride (MH) for chronic
periodontitis treatment. The physicochemical properties, phase structures, in vitro
drug release and pharmacodynamics of in situ liquid crystals were investigated. The
optimal formulation (phytantriol (PT)/propylene glycol (PG)/water, 63/27/10, w/w/w)
loaded with 20 mg/g MH was proved to be injectable. The precursor formulation can
form a cubic phase gel in excess water in 6.97 ± 0.10 s. The results of in vitro
drug release suggested the MH presented a sustained release for 4 days. Liquid
crystal precursor formulation significantly reduced gingival index, probing depth
and alveolar bone loss compared to the model group (p < 0.01). Besides, the
pathological characteristics of model rats were improved. The results suggested
that MH-loaded in situ cubic liquid crystal possessed of sustained release ability
and periodontal clinical symptoms improvement. The developed in situ cubic liquid
crystal may be a potentially carrier in the local delivery of MH for periodontal
diseases.
AN - rayyan-563560241
AU - Yang, Z.
AU - Liang, X.
AU - Jiang, X.
AU - Guo, J.
AU - Tao, Y.
AU - Wang, S.
AU - Cao, Y.
AU - Gui, S.
DO - 10.3390/molecules23092275
IS - 9
KW - minocycline
propylene glycol
water
alveolar bone loss
animal
chemistry
drug formulation
drug release
human
liquid crystal
medicinal chemistry
microbiology
pathology
periodontitis
rat
LA - English
PY - 2018
SN - 1420-3049
ST - Development and Evaluation of Minocycline Hydrochloride-Loaded In Situ Cubic
Liquid Crystal for Intra-Periodontal Pocket Administration
T2 - Molecules
TI - Development and Evaluation of Minocycline Hydrochloride-Loaded In Situ Cubic
Liquid Crystal for Intra-Periodontal Pocket Administration
VL - 23
ID - 13615
ER -
TY - JOUR
AB - Purpose: To evaluate the effect of patchouli alcohol (PA) on periodontitis
and reveal its possible mechanism. Methods: Primary human periodontal membrane
cells (PDLC) were isolated and treated with lipopolysaccharide (LPS) to establish a
periodontitis model. The MTT, flow cytometry and immunofluorescence assay were used
to determine the effect of PA on cell viability and apoptosis in PDLC exposed to
LPS. The inflammation status and osteoclast formation were measured using enzyme-
linked immunosorbent assay (ELISA) and TRAP staining. Immunoblot assays were
performed to analyze the effect of LPS on ERK and NF-κB pathways. Results:
Patchouli alcohol (PA) improved LPS-induced PDLC growth arrest (p < 0.001). In
addition, PA relieved LPS - induced autophagy of PDLCs (p < 0.001). Further data
confirmed that PA inhibited lPS-induced inflammation of PDLCs. In addition, PA
reduced osteoclast formation, and suppressed inflammation and autophagy, and also
reduced osteoclast formation by regulating ERK and NF-κB pathways. Conclusion:
Patchouli alcohol inhibits inflammation and autophagy, and decreases osteoclast
formation in periodontitis via the regulation of ERK and NF-κB signaling pathways.
Thus, this compound has potentials for development for the treatment of
periodontitis; however, in vivo studies should first be undertaken.
AN - rayyan-563559817
AU - Ye, F.
AU - Zhang, C.
DO - 10.4314/tjpr.v21i8.5
IS - 8
KW - chemiluminescence analyzer
ELISA kit
ELISA reader
flow cytometer
microplate reader
alcohol
cytokine
interleukin 6
interleukin 8
lipopolysaccharide
protein c fos
transcription factor NFAT
apoptosis
apoptosis rate
article
bicinchoninic acid assay
cell viability
chemoluminescence
controlled study
down regulation
epithelium cell
flow cytometry
human
human cell
immunoblotting
inflammation
low drug dose
macrophage
MAPK signaling
MTT assay
NF kB signaling
osteoclast
osteoclastogenesis
periodontitis
primary human periodontal membrane cell
LA - English
PY - 2022
SN - ["1596-9827", "1596-5996"]
SP - 1607-1613
ST - Patchouli alcohol suppresses inflammation and autophagy, and reduces
osteoclast formation in periodontitis via regulation of ERK and NF-κB signaling
pathways
TI - Patchouli alcohol suppresses inflammation and autophagy, and reduces
osteoclast formation in periodontitis via regulation of ERK and NF-κB signaling
pathways
VL - 21
ID - 13191
ER -
TY - JOUR
AB - In peridontial disease loss of tooth occures due to weakining of the
supporting structure (pocket) of teeth, to prevent this site specific injectable
drug delivery systems are required. In the present study six batches of
metronidazole gels were prepared using natural biodegradable polymers Chitosan,
guar gum and Locust bean gum in variable concentrations. The formulated gels were
characterized for surface pH, viscosity, syringeability, bioadhesion strength, in
vitro drug release studies and antimicrobial susceptibility test. The results
revealed that the surface pH was within the range of neutral pH. The bioadhesion
strength was maximum for F3 formulation (3% Chitosan); viscosity values were
ranging from 1453.33 ± 5.77 to 1995.00 ± 0.01 dyne/cm2. Best formulation in terms
of cumulative percent drug release along with bioadhesion was formulation F3 with
78.23 % drug release for 7 days and fulfilled many requirements of once a week
delivery system, easy to fabricate, cost effective, patient compliance is also very
high. Zone of inhibition was also satisfactory for all the formulations.
AN - rayyan-563560621
AU - Yellanki, S. K.
AU - Singh, J.
AU - Manvi, F. V.
IS - 2
KW - algaroba
chitosan
guar gum
metronidazole
placebo
polymer
adhesion
article
controlled study
drug screening
drug synthesis
gel
in vitro study
nonhuman
periodontitis
pH
viscosity
LA - English
PY - 2010
SN - 0975-6299
ST - Formulation, characterization and evaluation of metronidazole gel for local
TI - Formulation, characterization and evaluation of metronidazole gel for local
VL - 1
ID - 13995
ER -
TY - JOUR
AB - Aim To evaluate the antioxidant and pro-oxidant properties of chlorhexidine
(CHX). Methodology The scavenging and generation of reactive oxygen species (ROS)
by CHX in the presence or absence of saturated Ca(OH)2 solutions was evaluated. The
reaction emitted chemiluminescence in the presence of lucigenin thus was determined
by a luminometer to evaluate the levels of ROS production. Changes in DNA
conformation were analysed by agarose gel electrophoresis. Paired Student's t-test
was used to compare the difference between groups. Results Chlorhexidine (0.00002-
0.02%) effectively scavenged 56-88% of the superoxide radicals generated by the
xanthine/xanthine oxidase reaction. Through analysis of PUC18 DNA conformation
changes, CHX was shown to be a mild scavenger of hydroxyl radicals generated by
H2O2 plus FeCl2. However, CHX (>0.083%) decreased the mobility of PUC18 plasmid DNA
with potential production of DNA-DNA cross-link and severe DNA breaks (presence of
DNA smear) at further higher concentrations. Furthermore, CHX induced ROS
production including H2O2 and superoxide radicals in 0.1N NaOH (pH = 12.76) or
Ca(OH)2 (pH = 12.5) solutions. Conclusion Chlorhexidine exhibited both antioxidant
and pro-oxidant properties under different conditions. These events are possibly
involved in the killing of root canal and periodontal microorganisms when CHX and
Ca(OH)2 were used in combination or separately. Potential genotoxicity and tissue
damage when extruded into the periradicular tissue and at higher concentrations
should be considered during periodontal and endodontic practice. © 2007
International Endodontic Journal.
AN - rayyan-563560733
AU - Yeung, S. Y.
AU - Huang, C. S.
AU - Chan, C. P.
AU - Lin, C. P.
AU - Lin, H. N.
AU - Lee, P. H.
AU - Jia, H. W.
AU - Huang, S. K.
AU - Jeng, J. H.
AU - Chang, M. C.
DO - 10.1111/j.1365-2591.2007.01271.x
IS - 11
calcium hydroxide
chlorhexidine
hydrogen peroxide
scavenger
sodium hydroxide
article
chemistry
DNA damage
drug interaction
LA - English
PY - 2007
SN - ["0143-2885", "1365-2591"]
SP - 837-844
ST - Antioxidant and pro-oxidant properties of chlorhexidine and its interaction
with calcium hydroxide solutions
T2 - Int. Endod. J.
TI - Antioxidant and pro-oxidant properties of chlorhexidine and its interaction
with calcium hydroxide solutions
VL - 40
ID - 14107
ER -
TY - JOUR
AB - The objective of this study was to develop a novel subgingival sustained-
release system for local delivery of bioactive minocycline hydrochloride for
periodontal disease treatment in dogs. The system incorporated the Minocycline
hydrochloride-Calcium-Dextran sulfate sodium into a thermoresponsive Pluronic F127
hydrogel. Minocycline hydrochloride was sustained release from the system for up to
10 days and the release kinetics fit the power law model. The release medium had a
significant statistical difference in antimicrobial activity to Aggregatibacter
actinomycetemcomitans. The results showed the system was a promising subgingival
sustained-release minocycline hydrochloride delivery system for periodontal disease
treatment in dogs.
AN - rayyan-563562242
AU - Yi, T. T.
AU - Zhuang, G. Y.
AU - Wang, Y. L.
DO - 10.1590/1678-4162-12586
IS - 4
PY - 2022
SN - ["0102-0935", "1678-4162"]
SP - 641-648
ST - Delivery of active minocycline hydrochloride by local sustained-release
system of complex and thermoresponsive hydrogel for dogs
T2 - ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA
TI - Delivery of active minocycline hydrochloride by local sustained-release
system of complex and thermoresponsive hydrogel for dogs
VL - 74
Y2 - 7
ID - 15616
ER -
TY - JOUR
AB - The present study describes selected clinical and microbiological results
obtained by treatment with local (Elyzol) and systemic (Flagyl) use of
metronidazole alone and/or mechanical subgingival debridement in early onset
periodontitis (EOP). Twelve patients, with lesions not distributed as in classical
localized juvenile periodontitis, were included. They were randomly divided into
local and systemic treatment groups each comprising 6 individuals, in each of whom
4 sites (one site/quadrant) with a probing depth of > or = 5 mm were selected and
treated with separate treatment modalities. The overall treatment design provided 6
different test groups. Groups of quadrants received 1) scaling and root planing 2)
local metronidazole treatment 3) systemic metronidazole treatment 4) local
metronidazole combined with scaling and root planing 5) systemic metronidazole
combined with scaling and root planing 6) No treatment. The microbiological and
clinical effects of treatment modalities were monitored over 42 days. The results
demonstrated reductions in mean counts of obligate anaerobic and capnophilic
microorganisms coupled with significant improvements in mean clinical measurements
(gingivitis, probing depth, attachment level) in all groups, except the untreated.
Scaling and root planing provided an initial clinical improvement with a selective
reduction of periodontopathogens (92.6% obligate anaerobes, 42.9% capnophilic
microorganisms), whereas the combination of local or systemic metronidazole with
scaling and root planing were found superior in reducing capnophilic bacteria
(93.7% and 93.4%, respectively). It is of critical importance to have a treatment
rationale for EOP, since bacterial differences exist in the etiological subforms of
periodontitis. Microbial testing may be justified before prescribing the adjunctive
antibiotic and selecting the mode of delivery for the successful clinical
management of EOP.
AN - rayyan-563561057
AU - Yilmaz, S.
AU - Kuru, B.
AU - Noyan, U.
AU - Kadir, T.
AU - Acar, O.
AU - Büget, E.
IS - 2
KW - acylglycerol
antiinfective agent
drug derivative
Elyzol Dentalgel
metronidazole
sesame seed oil
adult
article
bacterium
clinical trial
comparative study
controlled study
female
gel
human
male
microbiology
periodontics
periodontitis
LA - English
PY - 1996
SN - 1018-5992
SP - 500-509
ST - A clinical and microbiological evaluation of systemic and local metronidazole
delivery in early onset periodontitis patients
T2 - J Marmara Univ Dent Fac
TI - A clinical and microbiological evaluation of systemic and local metronidazole
delivery in early onset periodontitis patients
VL - 2
ID - 14431
ER -
TY - JOUR
AB - Considering the significance of the gut microbiota on human health, there has
been ever-growing research and commercial interest in various aspects of probiotic
functional foods and drugs. A probiotic food requires cautious consideration in
terms of strain selection, appropriate process and storage conditions, cell
viability and functionality, and effective delivery at the targeted site. To
address these challenges, several technologies have been explored and some of them
have been adopted for industrial applicability. Encapsulation of probiotics has
been recognized as an effective way to stabilize them in their dried form. By
conferring a physical barrier to protect them from adverse conditions, the
encapsulation approach renders direct benefits on stability, delivery, and
functionality. Various techniques have been explored to encapsulate probiotics, but
it is noteworthy that the encapsulation method itself influences surface
morphology, viability, and survivability of probiotics. This review focuses on the
need to encapsulate probiotics, trends in various encapsulation techniques, current
research and challenges in targeted delivery, the market status of encapsulated
probiotics, and future directions. Specific focus has been given on various in
vitro methods that have been explored to better understand their delivery and
performance.
AN - rayyan-563559900
AU - Yoha, K. S.
AU - Nida, S.
AU - Dutta, S.
AU - Moses, J. A.
AU - Anandharamakrishnan, C.
DO - 10.1007/s12602-021-09791-7
IS - 1
KW - ferritin
gelatin
glucose
hydrogel
liposome
milk fat
omega 3 fatty acid
plasticizer
polymer
probiotic agent
pullulan
RNA 16S
vitamin D
whey protein
bacterial infection
bioluminescence
carcinogenesis
cell survival
cell viability
confocal microscopy
cross linking
electrospinning
emulsion
encapsulation
fermentation
flow cytometry
food industry
food packaging
food safety
freeze drying
gene sequence
genotype
glycolysis
immunomodulation
intestine flora
lactic acid bacterium
microencapsulation
microfluidics
nanoemulsion
nebulization
neuromodulation
newborn sepsis
periodontitis
pH
refraction index
review
spray drying
static electricity
stomach emptying
stomach pH
thermostability
LA - English
PY - 2022
SN - ["1867-1314", "1867-1306"]
SP - 15-48
ST - Targeted Delivery of Probiotics: Perspectives on Research and
Commercialization
T2 - Probiotics Antimicrob. Proteins
TI - Targeted Delivery of Probiotics: Perspectives on Research and
Commercialization
VL - 14
ID - 13274
ER -
TY - JOUR
AN - rayyan-563561468
AU - You, Z.
AU - Wu, Y.
AU - Sun, Y.
AU - Wang, Z.
AU - Ye, L.
DO - 10.7518/hxkq.2023.01.002
IS - 1
PY - 2023
SP - 11-20
ST - Application of gelatin methacryloyl/minocycline-chitosan-nanoparticles
composite hydrogel for the treatment of periodontitis
T2 - Hua Xi Kou Qiang Yi Xue Za Zhi / West China Journal of Stomatology
TI - Application of gelatin methacryloyl/minocycline-chitosan-nanoparticles
composite hydrogel for the treatment of periodontitis
85165084600&doi=10.7518%2fhxkq.2023.01.002&partnerID=40&md5=e2698406449acb952156870
e38a2dc50
VL - 41
ID - 14842
ER -
TY - JOUR
AB - An earlier study indicated that a chemically-modified non-antimicrobial
tetracycline (4-de-dimethylaminotetracycline; CMT-1) can inhibit excess collagenase
activity in the connective tissues of diabetic rats, however, the optimum oral dose
and resulting serum concentration were not determined. In the current study, adult
male Sprague-Dawley rats (body weight approx. 350 g) were made diabetic by
streptozotocin injection and administered by oral gavage either 0, 1, 2, 5, or 10
mg CMT-1 per day. After 3 weeks of drug therapy, the rats were killed and gingiva,
skin, and serum collected. The tissues were 1) extracted, partially purified and
analyzed for collagenase activity using [3H-methyl] collagen as substrate and SDS-
PAGE/fluorography; 2) extracted in neutral salt and dilute acid solutions (4
degrees C) to assess collagen solubility; and 3) analyzed for hydroxyproline to
determine tissue (skin) collagen mass. Serum was analyzed for glucose and CMT-1
concentration, the latter by HPLC. Inducing diabetes dramatically increased both
gingival and skin collagenase activity and reduced skin collagen mass by 69.8%.
Increasing the oral dose of CMT-1 progressively increased the serum concentration
of the drug from 0.6-6.5 micrograms/ml and progressively decreased the excessive
collagenase activity in gingiva and skin (p < 0.01 vs untreated diabetics).
Although skin collagen mass tended to be increased at all oral doses of CMT-1, only
the 5 mg dose effect was statistically significant (p < 0.01). The diabetes-induced
reduction in collagen solubility, a classic abnormality (reflecting excessive
collagen crosslinking) of this disease, was also normalized by CMT-1 therapy.
(ABSTRACT TRUNCATED AT 250 WORDS)
AN - rayyan-563561424
AU - Yu, Z.
AU - Leung, M.
AU - Chang, K. M.
AU - Golub, L. M.
IS - 6
KW - Administration, Oral
Animals
Collagen/chemistry/*metabolism
Diabetes Mellitus, Experimental/*drug therapy/*enzymology
Gingiva/enzymology
Hydroxyproline/analysis
Male
*Matrix Metalloproteinase Inhibitors
Rats
Skin/enzymology
Solubility
Structure-Activity Relationship
Tetracycline/*administration & dosage/therapeutic use
LA - eng
N1 - Department of Oral Biology & Pathology, SUNY, Stony Brook 11794.
PY - 1993
SN - 0022-3484 (Print)
SP - 420-8
ST - Chemically-modified tetracycline normalizes collagen metabolism in diabetic
rats: a dose-response study
TI - Chemically-modified tetracycline normalizes collagen metabolism in diabetic
rats: a dose-response study
VL - 28
Y2 - 11
ID - 14798
ER -
TY - JOUR
AB - Aim: Periodontal diseases are chronic, inflammatory, and infectious diseases.
Therefore, periodontal treatment aims to eliminate periodontopathogenic bacteria
causing periodontal diseases. The aim of the present study was to evaluate the
effect of commonly-used products such as acetic acid, sodium bicarbonate, and
sodium chloride on periodontopathogenic bacteria, Aggregatibacter
actinomycetemcomitans. Material and Method: In the present research, effects on
Aggregatibacter actinomycetemcomitans (ATCC 33384TM) were tested. Acetic acid,
sodium bicarbonate, and sodium chloride were used in 5% concentration dissolved in
distilled water. The negative control agent was distilled water and the positive
control agents were chlorhexidine, penicillin, tetracycline, and ciprofloxacin. The
antibacterial efficacy against bacteria was tested via disc-diffusion method,
minimum inhibitory concentration test, and minimum bactericidal concentration
tests. Results: The most antibacterial efficacy was found in ciprofloxacin.
Penicillin had moderate effect and chlorhexidine provided a similar efficacy.
Acetic acid provided an inhibitory effect higher than penicillin and chlorhexidine
against Aggregatibacter actinomycetemcomitans but lower than tetracycline and
ciprofloxacin. Sodium bicarbonate and sodium chloride showed no inhibitory effect.
Discussion: Acetic acid is commonly consumed in the form of vinegar. Due to its
antibacterial efficacy against Aggregatibacter actinomycetemcomitans, it can be
useful as an adjunct to periodontal treatment. Further studies to evaluate clinical
use of acetic acid as mouthwash, dentifrice, gel, and/or irrigation agent are
necessary.
AN - rayyan-563560317
AU - Yuce, H. B.
AU - Tulu, F.
AU - Karaman, I.
DO - 10.4328/JCAM.5031
KW - acetic acid
bicarbonate
chlorhexidine
ciprofloxacin
distilled water
metronidazole
sodium chloride
tetracycline
article
bacterium culture
controlled study
disk diffusion
drug efficacy
nonhuman
LA - English
PY - 2017
SN - ["1309-2014", "1309-0720"]
SP - 182-185
ST - Antibacterial effects of various chemical agents on aggregatibacter
T2 - Farkli kimyasal ajanlarin aggregatibacter actinomycetemcomitans bakterisi
üzerindeki antibakteriyel etkilerinin araştirilmasi
TI - Antibacterial effects of various chemical agents on aggregatibacter
VL - 8
ID - 13691
ER -
TY - JOUR
AB - The periodontal therapies along with systemic antibiotic therapy aim at
eliminating the subgingival microbiota to arrest the progression of periodontal
diseases. The complete elimination is often difficult, and thus the probability of
repopulation after periodontal therapy is also high. The objectives of the study
are to develop in situ thermoreversible gelling system of green tea catechins
suitable for periodontal pocket administration, which would act as an adjunct to
mechanical periodontal therapy. Gel is prepared on a weight basis using a cold
process. In vitro drug release pattern is observed through spectrophotometer
analysis at 277 nm. The gel is subjected to serial dilution analysis to determine
the minimum inhibitory concentration (MIC) and disc diffusion analysis to determine
the in vitro antibacterial effectiveness. Release pattern studies showed a complete
release of drug from gel occurred by 36 h. A volume of 1.25 mg/ml was determined as
MIC required against the periodontal pathogens. Disc diffusion analysis showed a 14
mm zone of inhibition is present around the 75 μl well for all the four species and
12 mm zone of inhibition around the 50 μl well. The advantage of F-127 is its
thermoreversible nature that used for in situ gel formulation. Pluronic gel proved
to be a promising carrier for prolong and effective release of green tea catechin.
AN - rayyan-563560369
AU - Yuvaraja, M.
AU - Raghavendra Reddy, N.
AU - Mohan Kumar, P.
AU - Ravi, K. S.
AU - Alqahtani, N.
DO - 10.4103/2231-4040.191422
IS - 4
KW - catechin
drug carrier
polymer
article
computer model
controlled study
disk diffusion
drug efficacy
drug release
gel
in vitro study
nonhuman
thermoreversible gel
LA - English
PY - 2016
SN - ["0976-2094", "2231-4040"]
SP - 139-143
ST - Thermoreversible gel for intrapocket delivery of green tea catechin as a
local drug delivery system: An original research
T2 - J. Adv. Pharm. Technol. Res.
TI - Thermoreversible gel for intrapocket delivery of green tea catechin as a
VL - 7
ID - 13743
ER -
TY - JOUR
AB - The periodontal therapies along with systemic antibiotic therapy aim at
eliminating the subgingival microbiota to arrest the progression of periodontal
diseases. The complete elimination is often difficult, and thus the probability of
repopulation after periodontal therapy is also high. The objectives of the study
are to develop in situ thermoreversible gelling system of green tea catechins
suitable for periodontal pocket administration, which would act as an adjunct to
mechanical periodontal therapy. Gel is prepared on a weight basis using a cold
process. In vitro drug release pattern is observed through spectrophotometer
analysis at 277 nm. The gel is subjected to serial dilution analysis to determine
the minimum inhibitory concentration (MIC) and disc diffusion analysis to determine
the in vitro antibacterial effectiveness. Release pattern studies showed a complete
release of drug from gel occurred by 36 h. A volume of 1.25 mg/ml was determined as
MIC required against the periodontal pathogens. Disc diffusion analysis showed a 14
mm zone of inhibition is present around the 75 µl well for all the four species and
12 mm zone of inhibition around the 50 µl well. The advantage of F-127 is its
thermoreversible nature that used for in situ gel formulation. Pluronic gel proved
to be a promising carrier for prolong and effective release of green tea catechin.
AN - rayyan-563561326
AU - Yuvaraja, M.
AU - Reddy, N. R.
AU - Kumar, P. M.
AU - Ravi, K. S.
AU - Alqahtani, N.
DO - 10.4103/2231-4040.191422
IS - 4
J2 - J Adv Pharm Technol Res
LA - eng
N1 - Department of Periodontics, Rajas Dental College and Hospital, Tirunelveli,
Tamil Nadu, India.; Department of Preventive Dental Science, College of Dentistry,
King Khalid University, Abha, Kingdom of Saudi Arabia.; Department of Periodontics,
St. Joseph Dental College, Eluru, Andhra Pradesh, India.; Department of Preventive
Dental Science, College of Dentistry, King Khalid University, Abha, Kingdom of
Saudi Arabia.; Department of Preventive Dental Science, College of Dentistry, King
Khalid University, Abha, Kingdom of Saudi Arabia.
PY - 2016
SN - 2231-4040 (Print)
SP - 139-143
ST - Thermoreversible gel for intrapocket delivery of green tea catechin as a
T2 - Journal of advanced pharmaceutical technology & research
TI - Thermoreversible gel for intrapocket delivery of green tea catechin as a
VL - 7
Y2 - 10
ID - 14700
ER -
TY - JOUR
AB - The relationships between hyaluronic acid (HA) and pathological
microorganisms incite new understandings on microbial infection, tissue
penetration, disease progression and lastly, potential treatments. These
understandings are important for the advancement of next generation antimicrobial
therapeutical strategies for the control of healthcare-associated infections.
Herein, this review will focus on the interplay between HA, bacteria, fungi, and
viruses. This review will also comprehensively detail and discuss the antimicrobial
activity displayed by various HA molecular weights for a variety of biomedical and
pharmaceutical applications, including microbiology, pharmaceutics, and tissue
engineering.
AN - rayyan-563559756
AU - Zamboni, F.
AU - Wong, C. K.
AU - Collins, M. N.
DO - 10.1016/j.bioactmat.2022.04.023
KW - amikacin
angiotensin converting enzyme 2
antifungal agent
antiinfective agent
antivirus agent
azithromycin
bone cement
cefotaxime
ceftazidime
chitosan
chloramphenicol
chlorhexidine
ciprofloxacin
clotrimazole
echinocandin
gentamicin
hepatitis B surface antigen
hyaluronic acid
hyaluronidase
hyaluronoglucosaminidase
hydrogel
hydroxyapatite
kanamycin
ketoconazole
nanoparticle
polymer
rifampicin
vancomycin
antifungal activity
antifungal resistance
antiviral activity
Aspergillus fumigatus
bacterial growth
bacterial infection
bacterial load
biocompatibility
Candida albicans
candidiasis
Haemophilus influenzae
healthcare associated infection
human
humoral immunity
immune response
Lactobacillus
molecular weight
Mycobacterium
mycosis
nonhuman
osteosynthesis
periodontal disease
review
Saccharomyces cerevisiae
tissue engineering
urinary tract infection
vaginitis
virus infection
LA - English
PY - 2023
SN - 2452-199X
SP - 458-473
ST - Hyaluronic acid association with bacterial, fungal and viral infections: Can
hyaluronic acid be used as an antimicrobial polymer for biomedical and
pharmaceutical applications?
T2 - Bioact. Mater.
TI - Hyaluronic acid association with bacterial, fungal and viral infections: Can
hyaluronic acid be used as an antimicrobial polymer for biomedical and
pharmaceutical applications?
VL - 19
ID - 13130
ER -
TY - JOUR
AB - INTRODUCTION: This in vitro study compared the antibacterial efficacy of 2.5%
sodium hypochlorite gel and 2.5% and 5.25% sodium hypochlorite solutions on
Enterococcus faecalis (E. faecalis) biofilm. METHODS AND MATERIALS: The root canals
of 60 extracted human single-rooted teeth were contaminated with E. faecalis and
incubated for 6 weeks. The samples were randomly assigned to three experimental
groups and one control group (n=15). The study protocol in the experimental groups
consisted of injection of 5 mL of each irrigant into the root canals. Samples were
collected from the root canal walls and 1:10 serial dilutions were prepared and
added to Muller Hinton Agar (MHA) plates and incubated at 37(°)C for 48 h. A
classic colony counting technique was used for determining vital E. faecalis
bacterial counts in MHA plates. The Kruskal-Wallis test was used for statistical
analysis of the data. The level of significance was set at 0.05. RESULTS: The
antibacterial effect of the irrigants in all three experimental groups was
significantly greater than the control group (P<0.05), with no significant
difference between 2.5% and 5.25% NaOCl solutions (P>0.05). The effect of 2.5% and
5.25% NaOCl solutions were significantly superior to 2.5% NaOCl gel (P<0.05).
CONCLUSION: Under the limitations of this study, 2.5% NaOCl gel was effective in
reducing E. faecalis counts; however this effect was less than that of NaOCl
solutions.
AN - rayyan-563561105
AU - Zand, V.
AU - Lotfi, M.
AU - Soroush, M. H.
AU - Abdollahi, A. A.
AU - Sadeghi, M.
AU - Mojadadi, A.
DO - 10.22037/iej.2016.11
IS - 4
J2 - Iran Endod J
LA - eng
N1 - Dental and Periodontal Research Center, Dental School, Tabriz University of
Medical Sciences, Tabriz, Iran.; Dental and Periodontal Research Center, Dental
School, Tabriz University of Medical Sciences, Tabriz, Iran.; Microbiology
Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz,
Iran.; Dental and Periodontal Research Center, Department of Endodontics, Student
Research Committee, Dental School, Tabriz University of Medical Sciences, Tabriz,
Iran.; Private Practice, Tabriz, Iran.; Dental and Periodontal Research Center,
Dental School, Tabriz University of Medical Sciences, Tabriz, Iran.
PY - 2016
SN - 1735-7497 (Print)
SP - 315-319
ST - Antibacterial Efficacy of Different Concentrations of Sodium Hypochlorite Gel
and Solution on Enterococcus faecalis Biofilm
TI - Antibacterial Efficacy of Different Concentrations of Sodium Hypochlorite Gel
and Solution on Enterococcus faecalis Biofilm
VL - 11
ID - 14479
ER -
TY - JOUR
AB - The aim of this study was to determine the effect of bone morphogenetic
protein-7 (BMP-7) and ornidazole (ORN) loaded Chitosan/beta-glycerophosphate
(CS/beta-GP) thermosensitive hydrogels on periodontal regeneration. CS/beta-GP
hydrogels with and without BMP-7 and ORN were compared with respect to
physicochemical properties, release kinetics, and antimicrobial activity in vitro,
and periodontal regeneration properties in class III furcation defects in beagles
via radiography, histology including immunohistochemical staining of osteoblasts
and osteoclasts, and histometric analysis. CS/beta-GP hydrogels with and without
BMP-7 and OM had comparable physicochemical properties and gelation kinetics.
Release kinetics showed that the hydrogels were capable of stable and sustained
release of BMP-7 and ORN. The hydrogels loaded with ORN exhibited obvious
antimicrobial activity against P. gingivalis. Histometric analysis quantitatively
showed significantly more new bone and cementum, and less connective tissue in
defects implanted with BMP-7 loaded hydrogels compared with hydrogels without BMP-
7. The number of osteoclasts reduced significantly in the CS/BMP-7/ORN and CS/BMP-7
groups, while the number of osteoblasts increased significantly in these groups.
Our findings showed that BMP-7 and ORN conferred additional advantages to the
CS/beta-GP hydrogel in periodontal regeneration and suggest potential consideration
of this approach for periodontal therapy.
AN - rayyan-563562367
AU - Zang, S. Q.
AU - Mu, R.
AU - Chen, F.
AU - Wei, X. C.
AU - Zhu, L.
AU - Han, B. Y.
AU - Yu, H. C.
AU - Bi, B.
AU - Chen, B.
AU - Wang, Q. T.
AU - Jin, L.
DO - 10.1016/j.msec.2019.02.024
PY - 2019
SN - ["0928-4931", "1873-0191"]
SP - 919-928
ST - Injectable chitosan/beta-glycerophosphate hydrogels with sustained release of
BMP-7 and ornidazole in periodontal wound healing of class III furcation defects
T2 - MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
TI - Injectable chitosan/beta-glycerophosphate hydrogels with sustained release of
VL - 99
Y2 - 6
ID - 15741
ER -
TY - JOUR
AB - The aim of this study was to determine the effect of bone morphogenetic
protein-7 (BMP-7) and ornidazole (ORN) loaded Chitosan/β-glycerophosphate (CS/β-GP)
thermosensitive hydrogels on periodontal regeneration. CS/β-GP hydrogels with and
without BMP-7 and ORN were compared with respect to physicochemical properties,
release kinetics, and antimicrobial activity in vitro, and periodontal regeneration
properties in class III furcation defects in beagles via radiography, histology
including immunohistochemical staining of osteoblasts and osteoclasts, and
histometric analysis. CS/β-GP hydrogels with and without BMP-7 and ORN had
comparable physicochemical properties and gelation kinetics. Release kinetics
showed that the hydrogels were capable of stable and sustained release of BMP-7 and
ORN. The hydrogels loaded with ORN exhibited obvious antimicrobial activity against
P. gingivalis. Histometric analysis quantitatively showed significantly more new
bone and cementum, and less connective tissue in defects implanted with BMP-7
loaded hydrogels compared with hydrogels without BMP-7. The number of osteoclasts
reduced significantly in the CS/BMP-7/ORN and CS/BMP-7 groups, while the number of
osteoblasts increased significantly in these groups. Our findings showed that BMP-7
and ORN conferred additional advantages to the CS/β-GP hydrogel in periodontal
regeneration and suggest potential consideration of this approach for periodontal
therapy.
AN - rayyan-563560187
AU - Zang, S.
AU - Mu, R.
AU - Chen, F.
AU - Wei, X.
AU - Zhu, L.
AU - Han, B.
AU - Yu, H.
AU - Bi, B.
AU - Chen, B.
AU - Wang, Q.
AU - Jin, L.
DO - 10.1016/j.msec.2019.02.024
chitosan
glycerophosphate
ornidazole
animal
chemistry
dog
drug effect
drug release
hydrogel
injection
kinetics
male
pathology
periodontal disease
periodontium
pharmacology
regeneration
temperature
viscosity
wound healing
LA - English
PY - 2019
SN - 1873-0191
SP - 919-928
ST - Injectable chitosan/β-glycerophosphate hydrogels with sustained release of
TI - Injectable chitosan/β-glycerophosphate hydrogels with sustained release of
VL - 99
ID - 13561
ER -
TY - JOUR
AB - Aim: To compare the antimicrobial activity of polyhexamethylene biguanide
(Prontosan wound gel, Pr) and chlorhexidine digluconate (CHX) after short-and
medium-term application with the disinfection ability of calcium hydroxide (Ca) in
a model using immature bovine teeth. Methods: Sixty immature bovine roots were
infected with Enterococcus faecalis and randomly assigned to six groups (n = 10).
Disinfectants were applied into the root canal for 10 min (CHX-10 min and Pr-10
min) or 7 days (CHX-7d, Pr-7d and Ca-7d(g)). In the negative control group (Co-n),
no disinfectant was used. Dentine samples were collected, and the total count of
bacteria and colony-forming units were determined. The log10-transformed Colony-
forming units (CFU) data were analysed using a Kruskal-Wallis test with post hoc
Wilcoxon multiple-comparison tests. Results: The application of disinfectants led
to a significant reduction in CFUs in all groups compared with group Co-n. When
compared to Ca-7d(g), CHX-7d (P = 0.290), CHX-10 min (P = 0.963) and Pr-7d (P =
0.095) revealed no significant differences. Pr-10 min had a significantly higher
CFU value than Ca-7d(g) (P = 0.0004), CHX-10 min (P = 0.0009) and Pr-7d (P =
0.0006). Conclusions: Within the limitations of this study, sufficient
antimicrobial effect may be reached by a short-term application of CHX. For the
application of 1% Prontosan wound gel, a medium-term use (7 day) is required, while
short-term use (10 min) is less effective.
AN - rayyan-563562547
AU - Zaugg, L. K.
AU - Zitzmann, N. U.
AU - Hauser-Gerspach, I.
AU - Waltimo, T.
AU - Weiger, R.
AU - Krastl, G.
DO - 10.1111/edt.12077
IS - 4
PY - 2014
SN - ["1600-4469", "1600-9657"]
SP - 326-331
ST - Antimicrobial activity of short- and medium-term applications of
polyhexamethylene biguanide, chlorhexidine digluconate and calcium hydroxide in
infected immature bovine teeth in vitro
T2 - DENTAL TRAUMATOLOGY
TI - Antimicrobial activity of short- and medium-term applications of
polyhexamethylene biguanide, chlorhexidine digluconate and calcium hydroxide in
infected immature bovine teeth in vitro
VL - 30
Y2 - 8
ID - 15921
ER -
TY - JOUR
AB - Background and Objective: Many physiological and pathophysiological
conditions are attributable in part to cytoskeletal regulation of cellular
responses to signals. Moesin (membrane-organizing extension spike protein), an ERM
(ezrin, radixin and moesin) family member, is involved in lipopolysaccharide (LPS)-
mediated events in mononuclear phagocytes; however, its role in signaling is not
fully understood. The aim of this study was to investigate the LPS-induced moesin
signaling pathways in macrophages. Material and Methods: Macrophages were
stimulated with 500 ng/mL LPS in macrophage serum-free medium. For blocking
experiments, cells were pre-incubated with anti-moesin antibody. Moesin total
protein and phosphorylation were studied with western blotting. Moesin mRNA was
assessed using quantitative real-time PCR. To explore binding of moesin to LPS,
native polyacrylamide gel electrophoresis (PAGE) gel shift assay was performed.
Moesin immunoprecipitation with CD14, MD-2 and Toll-like receptor 4 (TLR4) and co-
immunoprecipitation of MyD88-interleukin-1 receptor-associated kinase (IRAK) and
IRAK-tumor necrosis factor receptor-activated factor 6 (TRAF6) were analyzed.
Phosphorylation of IRAK and activities of MAPK, nuclear factor κB (NF-κB) and IκBα
were studied. Tumor necrosis factor α, interleukin-1β and interferon β were
measured by ELISA. Results: Moesin was identified as part of a protein cluster that
facilitates LPS recognition and results in the expression of proinflammatory
cytokines. Lipopolysaccharide stimulates moesin expression and phosphorylation by
binding directly to the moesin carboxyl-terminus. Moesin is temporally associated
with TLR4 and MD-2 after LPS stimulation, while CD14 is continuously bound to
moesin. Lipopolysaccharide-induced signaling is transferred downstream to p38,
p44/42 MAPK and NF-κB activation. Blockage of moesin function interrupts the LPS
response through an inhibition of MyD88, IRAK and TRAF6, negatively affecting
subsequent activation of the MAP kinases (p38 and ERK), NF-κB activation and
translocation to the nucleus. Conclusion: These results suggest an important role
for moesin in the innate immune response and TLR4-mediated pattern recognition in
periodontal disease. © 2010 John Wiley & Sons A/S.
AN - rayyan-563560626
AU - Zawawi, K. H.
AU - Kantarci, A.
AU - Schulze-Späte, U.
AU - Fujita, T.
AU - Batista, E. L.
AU - Amar, S.
AU - Van Dyke, T. E.
DO - 10.1111/j.1600-0765.2010.01271.x
IS - 5
KW - actin binding protein
autacoid
beta interferon
cytokine
I kappa B
interleukin 1 receptor associated kinase
interleukin 1beta
lipopolysaccharide
moesin
I kappa B kinase alpha
pattern recognition receptor
protein MD 2
signal transducing adaptor protein
tumor necrosis factor receptor associated factor 6
article
biosynthesis
cell culture
human
immunology
innate immunity
macrophage
metabolism
nonparametric test
phosphorylation
physiology
protein binding
signal transduction
tumor cell line
LA - English
PY - 2010
SN - ["0022-3484", "1600-0765"]
SP - 589-601
ST - Moesin-induced signaling in response to lipopolysaccharide in macrophages
TI - Moesin-induced signaling in response to lipopolysaccharide in macrophages
VL - 45
ID - 14000
ER -
TY - JOUR
AB - The aims of the present study were to evaluate the clinical efficacy of, and
to monitor microbiologically, repeated oral hygiene instructions alone or in
combination with metronidazole 25% gel or subgingival scaling with or without
metronidazole gel in treatment of new, residual or recurrent periodontal pockets in
previously treated adult periodontitis patients. Ten suitable patients were
included in this randomized single-blind clinical study with an intra-individual
design. Clinical parameters were measured before and at 1, 3, 6, 9 and 12 months
after treatment. Subgingival plaque samples were taken at every examination from
one selected site in each quadrant. Smears from plaque samples were silver-stained
and differential counting was performed under light microscopy at 1000X
magnification. Four treatment modalities: (i) oral hygiene instruction (OHI) alone;
(ii) OHI and metronidazole dental gel; (iii) OHI and subgingival scaling; (iv) OHI
and subgingival scaling plus metronidazole gel, were randomly assigned to one
quadrant of each patient. At the 12-month examination, the mean reductions in
probing pocket depth were 2.6 mm after OHI alone, 2.8 mm after OHI and
metronidazole gel, 3.3 mm after OHI and subgingival scaling and 2.6 mm after oral
OHI and subgingival scaling plus metronidazole gel. The mean gains in probing
attachment level were 2.2 mm, 1.9 mm, 2.7 mm and 1.6 mm, respectively. Although
there were statistically significant differences in treatment responses between
some treatment modalities at some time points, these were not considered to be
clinically significant. Differential counts showed a shift towards a healthy
microflora in response to all treatment modalities. From the 12-month results, it
was concluded that the metronidazole 25% gel produced positive effects on the
clinical parameters and on the subgingival plaque microbiological composition in
new, residual or recurrent pockets in previously treated chronic periodontitis
patients. However, the metronidazole gel alone or in combination with scaling does
not seem to have any additional clinically significant therapeutic effects over and
above those derived from improved oral hygiene resulting from monthly recalls, with
or without subgingival scaling.
AN - rayyan-563560759
AU - Zee, K. Y.
AU - Lee, D. H.
AU - Corbet, E. F.
IS - 4
metronidazole
adult
article
clinical trial
controlled study
education
epidemiology
female
human
male
microbiology
middle aged
mouth hygiene
periodontitis
LA - English
PY - 2006
SN - 1466-2094
SP - 125-135
ST - Repeated oral hygiene instructions alone, or in combination with
metronidazole dental gel with or without subgingival scaling in adult periodontitis
patients: a one-year clinical study
TI - Repeated oral hygiene instructions alone, or in combination with
metronidazole dental gel with or without subgingival scaling in adult periodontitis
patients: a one-year clinical study
VL - 8
ID - 14133
ER -
TY - JOUR
AB - Increasing evidence has shown a correlation between chronic periodontitis
(CP) and Alzheimer’s disease (AD). Nevertheless, there is still a lack of direct
evidence, and especially key molecules to connect the two diseases. This study aims
to investigate potential protein links between CP and AD within the inflammatory
aspect. The hippocampus of CP model mice and controls were collected, and changes
in protein expression were evaluated using two-dimensional differential in-gel
electrophoresis (2D-DIGE) analysis combined with liquid chromatography tandem mass
spectrometry. A total of 15 differentially expressed proteins were identified in CP
model mice, as compared with the controls. Among them, S100-A9, transthyretin,
Cofilin 2, peroxiredoxin 2, and lipocalin-2 were validated by Western blot
according to their dual function both in inflammation and AD. Based on 2D-DIGE
analysis, CP animal model had higher levels of S100-A9, Cofilin 2, peroxiredoxin 2,
and lipocalin-2 compared to controls. The level of Cofilin 2, one of the well-
established proteins in the pathology of AD, was strongly correlated with the time
course of CP pathology, indicating a specific molecular correlation between CP and
AD. Moreover, the in vivo results showed the level of Cofilin 2 increased
significantly along with a prominent increase of the phosphorylation of protein
phosphatase 2 (PP2A) and tau protein in the cell lysates of Porphyromonas
gingivalis (P.g-LPS)-treated SK-N-SH APPwt cells. Cofilin 2 inhibition resulted in
a sharp decrease in PP2A dependent of tau phosphorylation. Furthermore, tumor
growth factor (TGF)-β1 was one of the most important inflammatory cytokines for the
Pg-LPS-induced Cofilin 2 upregulation in SK-N-SH APPwt cells. These results showed
inflammation served as the bond between CP and AD, whereas inflammatory related
proteins could be the key linkers between the two diseases. Determining the
association between CP and AD at the molecular mechanism will not only hold the
direct evidence of the association between the two diseases but also provide a new
way of preventing and treating AD: the effective prevention and treatment of CP
could serve as a useful method to alleviate the development of AD.
AN - rayyan-563559960
AU - Zeng, Q.
AU - Fang, Q.
AU - Zhou, X.
AU - Yang, H.
AU - Dou, Y.
AU - Zhang, W.
AU - Gong, P.
AU - Rong, X.
DO - 10.3389/fnmol.2021.728184
KW - amyloid precursor protein
calgranulin B
cofilin 2
interleukin 1beta
interleukin 6
neutrophil gelatinase associated lipocalin
peroxiredoxin 2
phospholipid hydroperoxide glutathione peroxidase
phosphoprotein phosphatase 2
phosphoprotein phosphatase 2A
presenilin 1
tau protein
transthyretin
Alzheimer disease
animal experiment
animal model
article
cell lysate
gene expression
image analysis
immunofluorescence
immunoprecipitation
in vivo study
inflammation
Morris water maze test
mouse
nonhuman
protein expression
protein interaction
RNA interference
SK-N-SH cell line
spatial learning
LA - English
PY - 2021
SN - 1662-5099
ST - Cofilin 2 Acts as an Inflammatory Linker Between Chronic Periodontitis and
Alzheimer’s Disease in Amyloid Precursor Protein/Presenilin 1 Mice
T2 - Front. Mol. Neurosci.
TI - Cofilin 2 Acts as an Inflammatory Linker Between Chronic Periodontitis and
Alzheimer’s Disease in Amyloid Precursor Protein/Presenilin 1 Mice
VL - 14
ID - 13334
ER -
TY - JOUR
AB - Hydrogel drug delivery systems possess unique structures and properties and
hence can be injected and retained in the periodontal pocket for slow and
controlled release of medications with antibacterial, anti-inflammatory, and
periodontal tissue regeneration-promotional effects. Due to their safety,
practicability, and effectiveness, they show great potential in the treatment of
periodontitis. In this paper, we gave an overview of hydrogel drug delivery systems
in the treatment of periodontitis, summing up the classification and forms of the
drugs delivered and the strengths and weaknesses of common types of hydrogel
matrixes. In addition, we discussed properties required for hydrogel drug delivery
systems applicable in the treatment of periodontitis, including a certain level of
viscosity, suitable degradation cycle, and temperature sensitivity. Finally, we
summarized the stimulus responsiveness types of hydrogel drug delivery systems
applicable in the treatment of periodontitis, including pH-responsiveness, enzyme-
responsiveness, reactive oxygen species-responsiveness, light-responsiveness, and
sugar-responsiveness. In the future, researchers should make further investigation
into the clinical efficacy of hydrogel drug delivery systems and promote their
translation into clinical applications. Additionally, hydrogel drug delivery
systems carrying biologic drugs could be further investigated to promote
advancement in the field of periodontal tissue regeneration. Furthermore, the
response sources, realization strategies, and safe preparation methods of smart
hydrogel drug delivery systems should also be further clarified and explored to
achieve drug delivery of better efficiency and safety. In addition to drug
delivery, hydrogel matrixes with medicinal values also show great promises.
AN - rayyan-563559700
AU - Zeng, X.
AU - Liu, F.
DO - 10.12182/20230760203
IS - 4
hydrogel
chemistry
human
periodontitis
LA - Chinese
PY - 2023
SN - 1672-173X
SP - 721-725
ST - Latest Findings on Hydrogel Drug Delivery Systems in the Treatment of
Periodontitis
T2 - Sichuan Da Xue Xue Bao Yi Xue Ban
TI - Latest Findings on Hydrogel Drug Delivery Systems in the Treatment of
Periodontitis
VL - 54
ID - 13074
ER -
TY - JOUR
AB - Hydrogel drug delivery systems possess unique structures and properties and
hence can be injected and retained in the periodontal pocket for slow and
controlled release of medications with antibacterial, anti-inflammatory, and
periodontal tissue regeneration-promotional effects. Due to their safety,
practicability, and effectiveness, they show great potential in the treatment of
periodontitis. In this paper, we gave an overview of hydrogel drug delivery systems
in the treatment of periodontitis, summing up the classification and forms of the
drugs delivered and the strengths and weaknesses of common types of hydrogel
matrixes. In addition, we discussed properties required for hydrogel drug delivery
systems applicable in the treatment of periodontitis, including a certain level of
viscosity, suitable degradation cycle, and temperature sensitivity. Finally, we
summarized the stimulus responsiveness types of hydrogel drug delivery systems
applicable in the treatment of periodontitis, including pH-responsiveness, enzyme-
responsiveness, reactive oxygen species-responsiveness, light-responsiveness, and
sugar-responsiveness. In the future, researchers should make further investigation
into the clinical efficacy of hydrogel drug delivery systems and promote their
translation into clinical applications. Additionally, hydrogel drug delivery
systems carrying biologic drugs could be further investigated to promote
advancement in the field of periodontal tissue regeneration. Furthermore, the
response sources, realization strategies, and safe preparation methods of smart
hydrogel drug delivery systems should also be further clarified and explored to
achieve drug delivery of better efficiency and safety. In addition to drug
delivery, hydrogel matrixes with medicinal values also show great promises.
AN - rayyan-563560806
AU - Zeng, X.
AU - Liu, F.
DO - 10.12182/20230760203
IS - 4
J2 - Sichuan Da Xue Xue Bao Yi Xue Ban
KW - Humans
*Hydrogels/chemistry/therapeutic use
Anti-Inflammatory Agents/therapeutic use
LA - chi
N1 - West China School of Nursing, Sichuan University, Chengdu 610041, China.;
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral
Diseases,West China Hospital of Stomatology, Sichuan University, Chengdu 610041,
China.; State Key Laboratory of Oral Diseases & National Clinical Research Center
for Oral Diseases,West China Hospital of Stomatology, Sichuan University, Chengdu
610041, China.
PY - 2023
SN - 1672-173X (Print)
SP - 721-725
ST - [Latest Findings on Hydrogel Drug Delivery Systems in the Treatment of
Periodontitis]
T2 - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical
science edition
TI - [Latest Findings on Hydrogel Drug Delivery Systems in the Treatment of
Periodontitis]
VL - 54
Y2 - 7
ID - 14180
ER -
TY - JOUR
AB - Background To compare the therapeutic effect of photodynamic therapy (PDT)
with Toluidine blue O hydrogel versus systemic antibiotic (SA) in treating
periodontitis on rats. Methods Thirty-two Wistar rats were divided into four groups
and treated differently: Negative control (NC) group, normal rats; positive control
(PC) group, rats with periodontitis; SA group, rats with periodontitis treated with
systemic antibiotic; PDT group, rats with periodontitis treated with PDT. After
treatment, gingival sulcus bacterial load was measured by counting the colony
forming units per milliliter (CFU mL(-1)). The tooth and periodontal tissues were
histologically processed to analyze histological and immunohistochemical profile.
Gingival samples were obtained to quantify interleukin-1 beta (IL-1 beta) and tumor
necrosis factor-alpha (TNF-alpha) levels. Results Gingival sulcus bacteria load is
significantly lower in PDT group compared with the SA group. The histological
analysis showed that some extremely effective repair signs of periodontal tissue
were presented in PDT group, such as no periodontal pocket, no bone resorption, few
inflammatory cells, massive fibroblasts and collagen fibers. Several effective
repair signs of periodontal tissue were also observed in SA group, such as shallow
periodontal pocket, small amount of inflammatory cells, substantial fibroblasts and
collagen fibers. There were lower cyclooxygenase-2, matrix metalloproteinase -8
(MMP-8) and RANK immunolabeling, higher osteoprotegerin immunolabeling in PDT group
compared with SA group. The IL-1 beta and TNF-alpha levels in PDT group were lower
than those in NC group, but higher than those in SA group. Conclusion PDT was
effective to treat experimental periodontitis and was superior to systemic
metronidazole as a treatment for periodontitis.
AN - rayyan-563562240
AU - Zhang, J. X.
AU - Liang, H.
AU - Zheng, Y. X.
AU - Wang, D. C.
AU - Xia, J.
AU - Peng, W. M.
AU - Cheng, K. J.
AU - Wang, L. F.
AU - Liu, Y. F.
AU - Peng, W.
AU - Li, Q. Y.
DO - 10.1002/JPER.18-0305
IS - 7
PY - 2019
SN - ["0022-3492", "1943-3670"]
SP - 798-807
ST - Photodynamic therapy versus systemic antibiotic for the treatment of
periodontitis in a rat model
TI - Photodynamic therapy versus systemic antibiotic for the treatment of
VL - 90
Y2 - 7
ID - 15614
ER -
TY - JOUR
AB - Background: To compare the therapeutic effect of photodynamic therapy (PDT)
with Toluidine blue O hydrogel versus systemic antibiotic (SA) in treating
periodontitis on rats. Methods: Thirty-two Wistar rats were divided into four
groups and treated differently: Negative control (NC) group, normal rats; positive
control (PC) group, rats with periodontitis; SA group, rats with periodontitis
treated with systemic antibiotic; PDT group, rats with periodontitis treated with
PDT. After treatment, gingival sulcus bacterial load was measured by counting the
colony forming units per milliliter (CFU mL−1). The tooth and periodontal tissues
were histologically processed to analyze histological and immunohistochemical
profile. Gingival samples were obtained to quantify interleukin-1 beta (IL-1β) and
tumor necrosis factor-alpha (TNF-α) levels. Results: Gingival sulcus bacteria load
is significantly lower in PDT group compared with the SA group. The histological
analysis showed that some extremely effective repair signs of periodontal tissue
were presented in PDT group, such as no periodontal pocket, no bone resorption, few
inflammatory cells, massive fibroblasts and collagen fibers. Several effective
repair signs of periodontal tissue were also observed in SA group, such as shallow
periodontal pocket, small amount of inflammatory cells, substantial fibroblasts and
collagen fibers. There were lower cyclooxygenase-2, matrix metalloproteinase -8
(MMP-8) and RANK immunolabeling, higher osteoprotegerin immunolabeling in PDT group
compared with SA group. The IL-1β and TNF-α levels in PDT group were lower than
those in NC group, but higher than those in SA group. Conclusion: PDT was effective
to treat experimental periodontitis and was superior to systemic metronidazole as a
treatment for periodontitis.
AN - rayyan-563560212
AU - Zhang, J.
AU - Liang, H.
AU - Zheng, Y.
AU - Wang, D.
AU - Xia, J.
AU - Peng, W.
AU - Cheng, K.
AU - Wang, L.
AU - Liu, Y.
AU - Li, Q.
DO - 10.1002/JPER.18-0305
IS - 7
KW - animal cell
animal experiment
animal model
animal tissue
antibody labeling
article
bacterial load
collagen fiber
colony forming unit
controlled study
drug therapy
fibroblast
gene expression
gingiva
histopathology
inflammatory cell
nonhuman
osteolysis
periodontal pocket
periodontium
protein expression
rat
rat model
tooth tissue
Wistar rat
antibiotic agent
cyclooxygenase 2
endogenous compound
interleukin 1beta
metronidazole
osteoprotegerin
LA - English
PY - 2019
SN - 0022-3492
SP - 798-807
ST - Photodynamic therapy versus systemic antibiotic for the treatment of
TI - Photodynamic therapy versus systemic antibiotic for the treatment of
VL - 90
ID - 13586
ER -
TY - JOUR
AB - It has been reported that protein arginine methyltransferase 5 (PRMT5)
serves a significant role in osteogenic differentiation and inflammatory response.
Nevertheless, its role in periodontitis as well as its underlying mechanism remain
to be elucidated. The aim of the present study was to explore the role of PRMT5 in
periodontitis and whether PRMT5 could reduce liposaccharide (LPS)-induced
inflammation of human periodontal ligament stem cells (hPDLSCs) and promote
osteogenic differentiation through STAT3/NF-κB signaling. In the current study, the
expression levels of PRMT5 were determined in LPS-induced hPDLSCs by reverse
transcription-quantitative PCR and western blot analysis. ELISA and western blot
analysis were employed to assess the secretion and expression levels of inflamma-
tory factors, respectively. The osteogenic differentiation and mineralization
potential of hPDLSCs were evaluated using alkaline phosphatase (ALP) activity
assay, Alizarin red staining and western blot analysis. Additionally, western blot
analysis was applied to determine the expression levels of the STAT3/NF-κB
signaling pathway-related proteins. The results showed that the expression levels
of PRMT5 were significantly enhanced in LPS-induced hPDLSCs. Additionally, PRMT5
knockdown reduced the contents of IL-1β, IL-6, TNF-α, inducible nitric oxide
synthase and cyclooxygenase-2. PRMT5 depletion also enhanced ALP activity, improved
the mineralization ability and upregulated bone morphogenetic protein 2,
osteocalcin and runt-related transcription factor 2 in LPS-induced hPDLSCs.
Furthermore, PRMT5 knockdown inhibited inflammation and promoted the osteogenic
differentiation of hPDLSCs via blocking the activation of the STAT3/NF-κB signaling
pathway. In conclusion, PRMT5 inhibition suppressed LPS-induced inflammation and
accelerated osteogenic differentiation in hPDLSCs via regulating STAT3/NF-κB
signaling, thus providing a potential targeted therapy for the improvement of
periodontitis.
AN - rayyan-563559709
AU - Zhang, K.
AU - Changshun, L. I.
AU - Jian, S. U. N.
AU - Tian, X.
DO - 10.3892/etm.2023.11963
IS - 6
KW - ELISA kit
microscope
spectrophotometer
alizarin
cyclooxygenase 2
epz 015666 inhibitor
interleukin 1beta
interleukin 6
messenger RNA
osteocalcin
protein arginine methyl transferase 5
STAT3 protein
unclassified drug
apoptosis
article
controlled study
gene knockdown
human
human cell
inflammation
liposaccharide induced inflammation
microscopy
mineralization
optical density
osteogenic differentiation
periodontitis
protein concentration
protein expression
receptor upregulation
RNA extraction
sequence analysis
signal transduction
spectral sensitivity
Western blotting
NanoDrop 2000
LA - English
PY - 2023
SN - ["1792-1015", "1792-0981"]
ST - PRMT5 inhibition ameliorates inflammation and promotes the osteogenic
differentiation of LPS-induced periodontal stem cells via STAT3/NF-κB signaling
T2 - Exp. Ther. Med.
TI - PRMT5 inhibition ameliorates inflammation and promotes the osteogenic
differentiation of LPS-induced periodontal stem cells via STAT3/NF-κB signaling
VL - 25
ID - 13083
ER -
TY - JOUR
AB - The overprescription and improper use of antibiotics have contributed to the
evolution of bacterial resistance, making it urgent to develop alternative
therapies and agents with better efficacy as well as less toxicity to combat
bacterial infections and keep new resistance from developing. In this work, a novel
light-activable nanoantibiotic platform (TC-PCM@GNC-PND) was constructed by the
incorporation of gold nanocages (GNC) and two thermosensitive gatekeepers, phase-
change materials (PCM) and thermosensitive polymer poly(N-isopropylacrylamide-co-
diethylaminoethyl methacrylate) (PND), to realize precisely the synergy of
photothermal and antimicrobial drugs. GNC exhibits an excellent photothermal effect
owing to its strong absorbance in the near-infrared (NIR) region, and hollow
interiors make it a favorable vehicle for loading various antibiotics such as
tetracycline (TC). The release of the encapsulated drugs could be precisely
controlled by NIR light through the dual thermosensitive interaction of liquid-
solid transition of PCM and coil- granule transition of PND, improving efficacy and
alleviating side effects with on-demand drug release. The thermosensitive hydrogel
was formed in situ upon application with body temperature, enhancing retention of
the antimicrobial agent in local infectious sites. Highly effective ablation of
bacteria is achieved both in vitro and in periodontitis models with little toxicity
owing to the synergy of photothermal effects and chemotherapeutic drug release
induced by NIR. This study could provide guidance for the design of antibacterial
materials and shed substantial light on synergistic treatment.
AN - rayyan-563562333
AU - Zhang, L. L.
AU - Wang, Y. L.
AU - Wang, C.
AU - He, M.
AU - Wan, J. S.
AU - Wei, Y.
AU - Zhang, J. L.
AU - Yang, X. L.
AU - Zhao, Y. B.
AU - Zhang, Y. F.
DO - 10.1021/acsami.9b17335
IS - 3
PY - 2020
SN - ["1944-8244", "1944-8252"]
SP - 3354-3362
ST - Light-Activable On-Demand Release of Nano-Antibiotic Platforms for Precise
Synergy of Thermochemotherapy on Periodontitis
TI - Light-Activable On-Demand Release of Nano-Antibiotic Platforms for Precise
VL - 12
Y2 - 1 y3 - 22
ID - 15707
ER -
TY - JOUR
AB - The overprescription and improper use of antibiotics have contributed to the
evolution of bacterial resistance, making it urgent to develop alternative
therapies and agents with better efficacy as well as less toxicity to combat
bacterial infections and keep new resistance from developing. In this work, a novel
light-activable nano-antibiotic platform (TC-PCM@GNC-PND) was constructed by the
incorporation of gold nanocages (GNC) and two thermosensitive gatekeepers, phase-
change materials (PCM) and thermosensitive polymer poly(N-isopropylacrylamide-co-
diethylaminoethyl methacrylate) (PND), to realize precisely the synergy of
photothermal and antimicrobial drugs. GNC exhibits an excellent photothermal effect
owing to its strong absorbance in the near-infrared (NIR) region, and hollow
interiors make it a favorable vehicle for loading various antibiotics such as
tetracycline (TC). The release of the encapsulated drugs could be precisely
controlled by NIR light through the dual thermosensitive interaction of liquid-
solid transition of PCM and coil-granule transition of PND, improving efficacy and
alleviating side effects with on-demand drug release. The thermosensitive hydrogel
was formed in situ upon application with body temperature, enhancing retention of
the antimicrobial agent in local infectious sites. Highly effective ablation of
bacteria is achieved both in vitro and in periodontitis models with little toxicity
owing to the synergy of photothermal effects and chemotherapeutic drug release
induced by NIR. This study could provide guidance for the design of antibacterial
materials and shed substantial light on synergistic treatment.
AN - rayyan-563560138
AU - Zhang, L.
AU - Wang, Y.
AU - Wang, C.
AU - He, M.
AU - Wan, J.
AU - Wei, Y.
AU - Zhang, J.
AU - Yang, X.
AU - Zhao, Y.
AU - Zhang, Y.
DO - 10.1021/acsami.9b17335
IS - 3
doxorubicin
gold
nanomaterial
poly(N-isopropylacrylamide-co-diethyleneglycol methacrylate)
polymethacrylic acid derivative
tetracycline
animal
chemistry
devices
drug release
heat
human
infrared radiation
periodontitis
procedures
radiation response
rat
Sprague Dawley rat
LA - English
PY - 2020
SN - 1944-8252
SP - 3354-3362
ST - Light-Activable On-Demand Release of Nano-Antibiotic Platforms for Precise
TI - Light-Activable On-Demand Release of Nano-Antibiotic Platforms for Precise
VL - 12
ID - 13512
ER -
TY - JOUR
AB - The bactericidal effect on biofilm is the main challenge currently faced by
antibacterial agents. Nanoscale drug-delivery materials can enhance biofilm
penetrability and drug bioavailability, and have significant applications in the
biomedical field. Dental caries is a typical biofilm-related disease, and the
acidification of biofilm pH is closely related to the development of dental caries.
In this study, a pH-responsive core-shell nano micelle (mPEG-b-PDPA) capable of
loading hydrophobic antibacterial agents was synthesized and characterized,
including its ability to deliver antibacterial agents within an acidic biofilm. The
molecular structure of this diblock copolymer was determined by hydrogen-1 nuclear
magnetic resonance (H-1-NMR) and gel permeation chromatography (GPC). The
characters of the micelles were studied by dynamic light scattering (DLS), TEM, pH
titration, and drug release detection. It was found that the hydrophilic micelles
could deliver bedaquiline, a hydrophobic antibacterial agent on S. mutans, in
acidic environments and in mature biofilm. No cytotoxic effect on the periodontal
cells was detected within 48 h. This pH-responsive micelle, being able to load
hydrophobic antibacterial agent, has good clinical application potential in
preventing dental caries.
AN - rayyan-563562517
AU - Zhang, M.
AU - Yu, Z. Y.
AU - Lo, E. C. M.
DO - 10.3389/fmicb.2021.761583
PY - 2021
SN - 1664-302X
ST - A New pH-Responsive Nano Micelle for Enhancing the Effect of a Hydrophobic
Bactericidal Agent on Mature Streptococcus mutans Biofilm
TI - A New pH-Responsive Nano Micelle for Enhancing the Effect of a Hydrophobic
VL - 12
Y2 - 10 y3 - 18
ID - 15891
ER -
TY - JOUR
AB - The bactericidal effect on biofilm is the main challenge currently faced by
antibacterial agents. Nanoscale drug-delivery materials can enhance biofilm
penetrability and drug bioavailability, and have significant applications in the
biomedical field. Dental caries is a typical biofilm-related disease, and the
acidification of biofilm pH is closely related to the development of dental caries.
In this study, a pH-responsive core-shell nano micelle (mPEG-b-PDPA) capable of
loading hydrophobic antibacterial agents was synthesized and characterized,
including its ability to deliver antibacterial agents within an acidic biofilm. The
molecular structure of this diblock copolymer was determined by hydrogen-1 nuclear
magnetic resonance (1H-NMR) and gel permeation chromatography (GPC). The characters
of the micelles were studied by dynamic light scattering (DLS), TEM, pH titration,
and drug release detection. It was found that the hydrophilic micelles could
deliver bedaquiline, a hydrophobic antibacterial agent on S. mutans, in acidic
environments and in mature biofilm. No cytotoxic effect on the periodontal cells
was detected within 48 h. This pH-responsive micelle, being able to load
hydrophobic antibacterial agent, has good clinical application potential in
preventing dental caries.
AN - rayyan-563559950
AU - Zhang, M.
AU - Yu, Z.
AU - Lo, E. C. M.
DO - 10.3389/fmicb.2021.761583
KW - analytical equipment
Fluoview FV1000
force tensiometer
Sigma700
Sigma701
spectrometer
Zetasizer
bactericide
bedaquiline
copolymer
hydrogen
methoxypolyethyleneglycol b poly 2 (diisopropylamino) ethyl methacrylate
nano micelle
nanochain
nanomaterial
nanoparticle
poly(ethyl methacrylate)
unclassified drug
acidification
article
bacterial growth
cell counting
cell viability
colony forming unit
controlled study
cytotoxicity assay
dental caries
dispersity
drug release
hydrophilicity
hydrophobicity
IC50
micelle
nanoencapsulation
nonhuman
particle size
periodontium
pH
titrimetry
ultraviolet visible spectroscopy
zeta potential
AVANCE III
LA - English
PY - 2021
SN - 1664-302X
ST - A New pH-Responsive Nano Micelle for Enhancing the Effect of a Hydrophobic
TI - A New pH-Responsive Nano Micelle for Enhancing the Effect of a Hydrophobic
VL - 12
ID - 13324
ER -
TY - JOUR
AB - Many storage mediums are available for the storage of avulsed teeth to
preserve the viability of periodontal ligament (PDL) cells before replantation;
however, it is unclear which medium is the optimal option. We performed this
network meta-analysis to answer this question. A comprehensive search was conducted
in PubMed, EMBASE, and the Cochrane library to capture eligible studies
investigating the comparative efficacy of Hank's balanced salt solution (HBSS),
aloe vera gel (AVG), oral rehydration solution (ORS), coconut water, egg white,
green tea, propolis, saline, milk, and water. Statistical analysis was conducted
using Review Manager v5.3 and ADDIS v1.16.8. In total, 20 RCTs involving 31 reports
were included finally. Direct meta-analysis suggested that HBSS was superior to
ORS, milk, saline, and water, ORS was superior to milk but inferior to coconut
water and propolis, egg white was superior to milk but inferior to AVG and
propolis, propolis was superior to AVG, milk, and saline, and coconut water and
water was inferior to saline and milk, respectively. Network meta-analysis
suggested that AVG was inferior to the other nine mediums, and propolis was
superior to HBSS (SMD, −5260.24; 95% CrI, −10447.39 to −70.37) and milk (SMD,
−5461.11; 95% CrI, −10574.99 to −328.51). Moreover, ranking probabilities indicated
the highest probability for propolis, followed by saline, ORS, HBSS, milk, egg
white, water, green tea, and AVG successively. Propolis may be the optimal media
for storing avulsed teeth before replantation. However, given the availability of
propolis and HBSS and the hypotonic properties of saline, ORS or milk should also
be preferentially selected.
AN - rayyan-563559951
AU - Zhang, N.
AU - Cheng, Y.
AU - Li, F.
AU - Kang, Q.
DO - 10.3389/fmed.2021.749278
KW - information processing device
balanced salt solution
egg white
gel
oral rehydration solution
propolis
sodium chloride
water
adult
Aloe vera
cell viability
child
coconut milk
human
human cell
milk
network meta-analysis
organ preservation
review
systematic review
tea
tooth injury
tooth replantation
LA - English
PY - 2021
SN - 2296-858X
ST - Network Meta-Analysis of 10 Storage Mediums for Preserving Avulsed Teeth
T2 - Front. Med.
TI - Network Meta-Analysis of 10 Storage Mediums for Preserving Avulsed Teeth
VL - 8
ID - 13325
ER -
TY - JOUR
AB - The treatment of periodontitis focuses on controlling the progression of
inflammation, reducing plaque accumulation, and promoting bone tissue
reconstruction. Among them, the reconstruction of irregular bone resorption caused
by periodontitis is a long-standing challenge. At present, the local drug treatment
of periodontitis is mainly anti-inflammatory and antibacterial drugs. In this
study, psoralen (Pso), a Chinese herbal medicine with anti-inflammatory,
antibacterial, and osteogenic effects, was selected for the local treatment of
periodontitis. Meanwhile, an injectable methacrylate gelatin (GelMA) platform
loading with Pso was constructed. Pso-GelMA had the properties of fluidity, light
cohesion, self-healing, and slow release, which could be better used in the deep
and narrow structure of the periodontal pocket, and greatly increased the
effectiveness of local drug delivery. The pore size of Gelma hydrogel did not
change after loading Pso by SEM. In vitro, Pso-GelMA effectively upregulated the
expression of osteogenic genes and proteins, increased alkaline phosphatase
activity, promoted the mineralisation of rat bone marrow mesenchymal stem cells
(BMSCs) extracellular matrix, and had significant antibacterial effects on
Staphylococcus aureus and Fusobacterium nucleatum. Therefore, Pso-GelMA has immense
promise in the adjuvant treatment of periodontitis.
AN - rayyan-563562366
AU - Zhang, Q.
AU - Chu, F. H.
AU - Xu, Y. J.
AU - Wu, X. A.
AU - Yu, J.
AU - Cong, B. B.
AU - Wu, Y. T.
DO - 10.1049/nbt2.12136
IS - 4
PY - 2023
SN - ["1751-8741", "1751-875X"]
SP - 376-386
ST - Osteogenesis promotion by injectable methacryloylated gelatin containing
psoralen and its bacteriostatic properties
T2 - IET NANOBIOTECHNOLOGY
TI - Osteogenesis promotion by injectable methacryloylated gelatin containing
VL - 17
Y2 - 6
ID - 15740
ER -
TY - JOUR
AB - The treatment of periodontitis focuses on controlling the progression of
inflammation, reducing plaque accumulation, and promoting bone tissue
reconstruction. Among them, the reconstruction of irregular bone resorption caused
by periodontitis is a long-standing challenge. At present, the local drug treatment
of periodontitis is mainly anti-inflammatory and antibacterial drugs. In this
study, psoralen (Pso), a Chinese herbal medicine with anti-inflammatory,
antibacterial, and osteogenic effects, was selected for the local treatment of
periodontitis. Meanwhile, an injectable methacrylate gelatin (GelMA) platform
loading with Pso was constructed. Pso-GelMA had the properties of fluidity, light
cohesion, self-healing, and slow release, which could be better used in the deep
and narrow structure of the periodontal pocket, and greatly increased the
effectiveness of local drug delivery. The pore size of Gelma hydrogel did not
change after loading Pso by SEM. In vitro, Pso-GelMA effectively upregulated the
expression of osteogenic genes and proteins, increased alkaline phosphatase
activity, promoted the mineralisation of rat bone marrow mesenchymal stem cells
(BMSCs) extracellular matrix, and had significant antibacterial effects on
Staphylococcus aureus and Fusobacterium nucleatum. Therefore, Pso-GelMA has immense
promise in the adjuvant treatment of periodontitis.
AN - rayyan-563559713
AU - Zhang, Q.
AU - Chu, F.
AU - Xu, Y.
AU - Wu, X.
AU - Yu, J.
AU - Cong, B.
AU - Wu, Y.
DO - 10.1049/nbt2.12136
IS - 4
gelatin
hydrogel
psoralen
animal
bone development
chemistry
periodontitis
rat
LA - English
PY - 2023
SN - 1751-875X
SP - 376-386
ST - Osteogenesis promotion by injectable methacryloylated gelatin containing
T2 - IET Nanobiotechnol
TI - Osteogenesis promotion by injectable methacryloylated gelatin containing
VL - 17
ID - 13087
ER -
TY - JOUR
AB - Minocycline hydrochloride (MINO) has been one of the most frequently used
antibiotics in the treatment of periodontitis due to its antibacterial activity and
osteogenesis effects; however, high levels of MINO administered during the
treatment halt the formation of new bone. Therefore, the purpose of the present
study was to prepare a MINO-microsphere/sucrose acetate isobutyrate (SAIB) hybrid
depot to reduce the burst release of MINO and ensure antibacterial and osteogenesis
effects of MINO in the treatment of periodontitis. Uniform microspheres,
approximately 5 mu m size, with a slightly rough surface and different MINO loading
(10, 12, and 14%) were prepared, and the microspheres were added into SAIB, after
which the burst release significantly decreased from 66.18 to 2.92%, from 71.82 to
3.82%, and from 73.35 to 4.45%, respectively, and the release from all the MINO-
microspheres/SAIB hybrid depots lasted for 77 days. In addition, cytotoxicity test
showed that the MINO-microsphere with 12% drug loading promoted the proliferation
of osteoblasts the most and was subsequently used in vivo experiments. Moreover, in
the model of ligatured-induced periodontitis in SD rats, the MINO-microsphere/SAIB
hybrid depot not only significantly increased the alveolar bone height and bone
volume but also reduced the inflammation of the periodontal tissue. Additionally,
it also inhibited the expression of the receptor activator of nuclear factor-kappa
B ligand (RANKL) and promoted the expression of osteoprotegerin (OPG).. These
results indicated that the MINO-microsphere/SAIB hybrid depot might be promising in
the treatment of periodontitis.
AN - rayyan-563562311
AU - Zhang, T.
AU - Qiu, Y. Q.
AU - Song, J. L.
AU - Zhou, P. F.
AU - Liao, H.
AU - Cheng, Y. T.
AU - Wu, X. H.
DO - 10.1080/10717544.2021.1902020
IS - 1
PY - 2021
SN - ["1071-7544", "1521-0464"]
SP - 620-633
ST - Electrosprayed minocycline hydrochloride-loaded microsphere/SAIB hybrid depot
T2 - DRUG DELIVERY
TI - Electrosprayed minocycline hydrochloride-loaded microsphere/SAIB hybrid depot
VL - 28
Y2 - 1 y3 - 1
ID - 15685
ER -
TY - JOUR
AB - Hydrogels are extracellular-matrix-like biomimetic materials that have wide
biomedical applications in tissue engineering and drug delivery. However, most
hydrogels cannot simultaneously fulfill the mechanical and cell compatibility
requirements. In the present study, we prepared a semi-interpenetrating network
composite gel (CG) by incorporating short chain chitosan (CS) into a covalent
tetra-armed poly(ethylene glycol) network. In addition to satisfying
physicochemical, mechanics, biocompatibility, and cell affinity requirements, this
CG easily encapsulated acetylsalicylic acid (ASA) via electrostatic interactions
and chain entanglement, achieving sustained release for over 14 days and thus
promoting periodontal ligament stem cell (PDLSC) proliferation and osteogenic
differentiation. In vivo studies corroborated the capacity of PDLSCs and ASA-laden
CG to enhance new bone regeneration in situ using a mouse calvarial bone defect
model. This might be attributed to PDLSCs and host mesenchymal stem cells
expressing monocyte chemoattractant protein-1, which upregulated M2 macrophage
recruitment and polarization in situ, indicating its appealing potential in bone
tissue engineering.
AN - rayyan-563559851
AU - Zhang, Y.
AU - Dou, X.
AU - Zhang, L.
AU - Wang, H.
AU - Zhang, T.
AU - Bai, R.
AU - Sun, Q.
AU - Wang, X.
AU - Yu, T.
AU - Wu, D.
AU - Han, B.
AU - Deng, X.
DO - 10.1016/j.bioactmat.2021.09.033
KW - culture medium
ELISA kit
FT -IR
imageJ2 software
imaging software
microscope
NanoDrop 8000 spectrophotometer
nucleic acid amplification system
microscopy
partial coherence interferometry biometer
qPCR RT Master Mix
spectrophotometer
trephine
2 propanol
alcohol
alizarin red s
biomimetic material
chitosan
chloroform
cholecystokinin octapeptide
complementary DNA
dexamethasone sodium phosphate
glutamine
glutaraldehyde
hydrogel
monocyte hemoattractant rotein1
osteocalcin
paraformaldehyde
potassium bromide
primer DNA
proteinase K
RNA
streptomycin
trypsin
ammonolysis
animal cell
animal experiment
animal model
animal tissue
article
biocompatibility
bone development
bone regeneration
cell isolation
cell proliferation
cell viability
controlled study
covalent bond
cytotoxicity
fetal bovine serum
gene expression
histology
infrared radiation
M2 macrophage
mechanics
mouse
nitroblue tetrazolium test
nonhuman
osteoblast
physical chemistry
polarization
porosity
proliferation index
protein expression
static electricity
tissue engineering
aspirin
optical microscopy
LA - English
PY - 2022
SN - 2452-199X
SP - 130-139
ST - Facile fabrication of a biocompatible composite gel with sustained release of
aspirin for bone regeneration
T2 - Bioact. Mater.
TI - Facile fabrication of a biocompatible composite gel with sustained release of
aspirin for bone regeneration
VL - 11
ID - 13225
ER -
TY - JOUR
AB - There are many restrictions on topical medications for the oral cavity.
Various factors affect the topical application of drugs in the oral cavity, an open
and complex environment. The complex physical and chemical environment of the oral
cavity, such as saliva and food, will influence the effect of free drugs.
Therefore, drug delivery systems have served as supporting structures or as
carriers loading active ingredients, such as antimicrobial agents and growth
factors (GFs), to promote antibacterial properties, tissue regeneration, and
engineering for drug diffusion. These drug delivery systems are considered in the
prevention and treatment of dental caries, periodontal disease, periapical disease,
the delivery of anesthetic drugs, etc. These carrier materials are designed in
different ways for clinical application, including nanoparticles, hydrogels,
nanofibers, films, and scaffolds. This review aimed to summarize the advantages and
disadvantages of different carrier materials. We discuss synthesis methods and
their application scope to provide new perspectives for the development and
preparation of more favorable and effective local oral drug delivery systems.
AN - rayyan-563562470
AU - Zhang, Y.
AU - Jiang, R. N.
AU - Lei, L.
AU - Yang, Y. M.
AU - Hu, T.
DO - 10.1590/1678-7757-2021-0349
PY - 2022
SN - ["1678-7757", "1678-7765"]
ST - Drug delivery systems for oral disease applications
T2 - JOURNAL OF APPLIED ORAL SCIENCE
TI - Drug delivery systems for oral disease applications
VL - 30
ID - 15844
ER -
TY - JOUR
AB - There are many restrictions on topical medications for the oral cavity.
Various factors affect the topical application of drugs in the oral cavity, an open
and complex environment. The complex physical and chemical environment of the oral
cavity, such as saliva and food, will influence the effect of free drugs.
Therefore, drug delivery systems have served as supporting structures or as
carriers loading active ingredients, such as antimicrobial agents and growth
factors (GFs), to promote antibacterial properties, tissue regeneration, and
engineering for drug diffusion. These drug delivery systems are considered in the
prevention and treatment of dental caries, periodontal disease, periapical disease,
the delivery of anesthetic drugs, etc. These carrier materials are designed in
different ways for clinical application, including nanoparticles, hydrogels,
nanofibers, films, and scaffolds. This review aimed to summarize the advantages and
disadvantages of different carrier materials. We discuss synthesis methods and
their application scope to provide new perspectives for the development and
preparation of more favorable and effective local oral drug delivery systems.
AN - rayyan-563560804
AU - Zhang, Y.
AU - Jiang, R.
AU - Lei, L.
AU - Yang, Y.
AU - Hu, T.
DO - 10.1590/1678-7757-2021-0349
J2 - J Appl Oral Sci
KW - *Dental Caries/drug therapy/prevention & control
Humans
*Mouth Diseases/drug therapy
*Nanofibers
*Nanoparticles
LA - eng
N1 - Sichuan University, West China Hospital of Stomatology, Department of
Preventive Dentistry, State Key Laboratory of Oral Diseases, Chengdu, China.;
Sichuan University, West China Hospital of Stomatology, Department of Preventive
Dentistry, State Key Laboratory of Oral Diseases, Chengdu, China.; Sichuan
University, West China Hospital of Stomatology, Department of Preventive Dentistry,
State Key Laboratory of Oral Diseases, Chengdu, China.; Sichuan University, West
China Hospital of Stomatology, Department of Preventive Dentistry, State Key
Laboratory of Oral Diseases, Chengdu, China.; Sichuan University, West China
Hospital of Stomatology, Department of Preventive Dentistry, State Key Laboratory
of Oral Diseases, Chengdu, China.
PY - 2022
SP - e20210349
ST - Drug delivery systems for oral disease applications
T2 - Journal of applied oral science : revista FOB
TI - Drug delivery systems for oral disease applications
VL - 30
ID - 14178
ER -
TY - JOUR
AB - BACKGROUND: Subgingival applications of chlorhexidine (CHX) gel are commonly
used as an adjunct in nonsurgical periodontal treatment (NSPT) for chronic
periodontitis (CP). However, there is lack of systematic review and meta-analysis
justifying the effects of adjunctive CHX gel on clinical outcomes. The objective of
this meta-analysis was to evaluate the efficacy of adjunctive subgingival
administration of CHX gel in NSPT compared to NSPT alone for CP. METHODS: An
electronic search of four databases and a manual search of four journals were
conducted up to August 2019. Only randomized controlled trials reporting on the
clinical outcomes of subgingival use of CHX gel adjunct to scaling and root planing
(SRP), as compared to SRP alone or with placebo, for at least 3 months were
included. Primary outcomes were probing pocket depth (PPD) reduction and clinical
attachment level (CAL) gain at 3 and 6 months, when data on at least three studies
were obtained. RESULTS: Seventeen studies were included for qualitative analysis
and seven studies for quantitative analysis (four studies for the application of
CHX gel adjunct to SRP at selected sites with at least pocket depth ≥ 4 mm and
three studies for comparison of full-mouth disinfection (FMD) with subgingival use
of CHX gel and full-mouth scaling and root planing (FMSRP). For subgroups, the
clinical outcomes between adjunctive use of Xanthan-based CHX gel (XAN-CHX gel) and
CHX gel were analyzed. Results indicated a significant improvement of PPD reduction
following local adjunctive administration of XAN-CHX gel for SRP at selected sites
(MD: 0.15 mm). However, no difference was found in CAL gain. Moreover, no
significant difference was observed in PPD and CAL at both 3 and 6 months post-
treatment between FMD and FMSRP. CONCLUSION: Adjunctive subgingival administration
of XAN-CHX gel at individual selected sites in NSPT appears to provide slight
benefits in PPD reduction compared to NSPT alone for CP. Due to the lack of high-
quality studies, further studies with larger sample sizes and strict standards are
needed to confirm the conclusions.
AN - rayyan-563560137
AU - Zhao, H.
AU - Hu, J.
AU - Zhao, L.
DO - 10.1186/s12903-020-1021-0
IS - 1
KW - chlorhexidine
aged
dental scaling
human
lavage
meta analysis
root planing
LA - English
PY - 2020
SN - 1472-6831
SP - 34
ST - Adjunctive subgingival application of Chlorhexidine gel in nonsurgical
periodontal treatment for chronic periodontitis: a systematic review and meta-
analysis
TI - Adjunctive subgingival application of Chlorhexidine gel in nonsurgical
periodontal treatment for chronic periodontitis: a systematic review and meta-
analysis
VL - 20
ID - 13511
ER -
TY - JOUR
AB - The complexity of periodontitis, including the complex formation mechanisms
and the complex periodontium physiological environment, as well as the complex
association with multiple complications, often results in poor therapy effects.
Herein, we aimed to design a nanosystem with a controlled release of minocycline
hydrochloride (MH) and good retention to effectively treat periodontitis by
inhibiting inflammation and repairing the alveolar bone. Firstly, insoluble ion-
pairing (IIP) complexes were constructed to improve the encapsulation efficiency of
hydrophilic MH in PLGA nanoparticles. Then, a nanogenerator was constructed and
combined with a double emulsion method to encapsulate the complexes into PLGA
nanoparticles (MH-NPs). The average particle size of MH-NPs was about 100 nm as
observed by AFM and TEM, and the drug loading and encapsulation efficiency were
9.59% and 95.58%, respectively. Finally, a multifunctional system (MH-NPs-in-gels)
was prepared by dispersing MH-NPs into thermosensitive gels, which could continue
to release drug for 21 days in vitro. And the release mechanism showed that this
controlled release behavior for MH was influenced by the insoluble ion-pairing
complex, PLGA nanoparticles, and gels. In addition, the periodontitis rat model was
established to investigate the pharmacodynamic effects. After 4 weeks of treatment,
changes in the alveolar bone were assessed by Micro-CT (BV/TV: 70.88%; BMD: 0.97
g/cm3; TB.Th: 0.14 mm; Tb.N: 6.39 mm−1; Tb.Sp: 0.07 mm). The mechanism of MH-NPs-
in-gels in vivo was clarified by the analysis of pharmacodynamic results, which
showed that insoluble ion-pairing complexes with the aid of PLGA nanoparticles and
gels achieved significant anti-inflammatory effects and bone repair capabilities.
In conclusion, the multiple controlled-release hydrophilicity MH delivery system
would have good prospects for the effective treatment of periodontitis.
AN - rayyan-563559722
AU - Zhao, J.
AU - Wei, Y.
AU - Xiong, J.
AU - Liu, H.
AU - Lv, G.
AU - He, H.
AU - Gou, J.
AU - Yin, T.
AU - Tang, X.
AU - Zhang, Y.
DO - 10.1016/j.ijpharm.2023.122802
gel
interleukin 10
isoflurane
minocycline
osteopontin
polyglactin
alveolar bone
alveolar crest
animal cell
animal experiment
animal model
animal tissue
article
biocompatibility
bone density
bone remodeling
bone strength
bone tissue
bone volume
cell viability
controlled study
disease severity
dispersity
edema
glucose intake
hydrophilicity
in vitro study
M1 macrophage
male
mouse
nanoencapsulation
nonhuman
osteoblast
osteolysis
particle size
periodontal disease
periodontal pocket
periodontitis
pharmacodynamics
rat
static electricity
trabecular number
trabecular separation
ulcer
ultrasound
zeta potential
LA - English
PY - 2023
SN - ["1873-3476", "0378-5173"]
ST - A multiple controlled-release hydrophilicity minocycline hydrochloride
delivery system for the efficient treatment of periodontitis
T2 - Int. J. Pharm.
TI - A multiple controlled-release hydrophilicity minocycline hydrochloride
delivery system for the efficient treatment of periodontitis
VL - 636
ID - 13096
ER -
TY - JOUR
AB - Background: Ventilator-associated pneumonia (VAP) is defined as pneumonia
developing in people who have received mechanical ventilation for at least 48
hours. VAP is a potentially serious complication in these patients who are already
critically ill. Oral hygiene care (OHC), using either a mouthrinse, gel, swab,
toothbrush, or combination, together with suction of secretions, may reduce the
risk of VAP in these patients. Objectives: To assess the effects of oral hygiene
care (OHC) on incidence of ventilator-associated pneumonia in critically ill
patients receiving mechanical ventilation in hospital intensive care units (ICUs).
Search methods: Cochrane Oral Health’s Information Specialist searched the
following databases: Cochrane Oral Health’s Trials Register (to 25 February 2020),
the Cochrane Central Register of Controlled Trials (CENTRAL) (the Cochrane Library,
2020, Issue 1), MEDLINE Ovid (1946 to 25 February 2020), Embase Ovid (1980 to 25
February 2020), LILACS BIREME Virtual Health Library (1982 to 25 February 2020) and
CINAHL EBSCO (1937 to 25 February 2020). We also searched the VIP Database (January
2012 to 8 March 2020). The US National Institutes of Health Trials Registry
(ClinicalTrials.gov) and the World Health Organization International Clinical
Trials Registry Platform were searched for ongoing trials. No restrictions were
placed on the language or date of publication when searching the electronic
databases. Selection criteria: We included randomised controlled trials (RCTs)
evaluating the effects of OHC (mouthrinse, gel, swab, toothbrush or combination) in
critically ill patients receiving mechanical ventilation for at least 48 hours.
Data collection and analysis: At least two review authors independently assessed
search results, extracted data and assessed risk of bias in included studies. We
contacted study authors for additional information. We reported risk ratio (RR) for
dichotomous outcomes and mean difference (MD) for continuous outcomes, using the
random-effects model of meta-analysis when data from four or more trials were
combined. Main results: We included 40 RCTs (5675 participants), which were
conducted in various countries including China, USA, Brazil and Iran. We
categorised these RCTs into five main comparisons: chlorhexidine (CHX) mouthrinse
or gel versus placebo/usual care; CHX mouthrinse versus other oral care agents;
toothbrushing (± antiseptics) versus no toothbrushing (± antiseptics); powered
versus manual toothbrushing; and comparisons of other oral care agents used in OHC
(other oral care agents versus placebo/usual care, or head-to-head comparisons
between other oral care agents). We assessed the overall risk of bias as high in 31
trials and low in two, with the rest being unclear. Moderate-certainty evidence
from 13 RCTs (1206 participants, 92% adults) shows that CHX mouthrinse or gel, as
part of OHC, probably reduces the incidence of VAP compared to placebo or usual
care from 26% to about 18% (RR 0.67, 95% confidence intervals (CI) 0.47 to 0.97; P
= 0.03; I2 = 66%). This is equivalent to a number needed to treat for an additional
beneficial outcome (NNTB) of 12 (95% CI 7 to 128), i.e. providing OHC including CHX
for 12 ventilated patients in intensive care would prevent one patient developing
VAP. There was no evidence of a difference between interventions for the outcomes
of mortality (RR 1.03, 95% CI 0.80 to 1.33; P = 0.86, I2 = 0%; 9 RCTs, 944
participants; moderate-certainty evidence), duration of mechanical ventilation (MD
-1.10 days, 95% CI -3.20 to 1.00 days; P = 0.30, I2 = 74%; 4 RCTs, 594
participants; very low-certainty evidence) or duration of intensive care unit (ICU)
stay (MD -0.89 days, 95% CI -3.59 to 1.82 days; P = 0.52, I2 = 69%; 5 RCTs, 627
participants; low-certainty evidence). Most studies did not mention adverse
effects. One study reported adverse effects, which were mild, with similar
frequency in CHX and control groups and one study reported there were no adverse
effects. Toothbrushing (± antiseptics) may reduce the incidence of VAP (RR 0.61, 5%
CI 0.41 to 0.91; P = 0.01, I2 = 40%; 5 RCTs, 910 participants; low-certainty
evidence) compared to OHC without toothbrushing (± antiseptics). There is also some
evidence that toothbrushing may reduce the duration of ICU stay (MD -1.89 days, 95%
CI -3.52 to -0.27 days; P = 0.02, I2 = 0%; 3 RCTs, 749 participants), but this is
very low certainty. Low-certainty evidence did not show a reduction in mortality
(RR 0.84, 95% CI 0.67 to 1.05; P = 0.12, I2 = 0%; 5 RCTs, 910 participants) or
duration of mechanical ventilation (MD -0.43, 95% CI -1.17 to 0.30; P = 0.25, I2 =
46%; 4 RCTs, 810 participants). Authors' conclusions: Chlorhexidine mouthwash or
gel, as part of OHC, probably reduces the incidence of developing ventilator-
associated pneumonia (VAP) in critically ill patients from 26% to about 18%, when
compared to placebo or usual care. We did not find a difference in mortality,
duration of mechanical ventilation or duration of stay in the intensive care unit,
although the evidence was low certainty. OHC including both antiseptics and
toothbrushing may be more effective than OHC with antiseptics alone to reduce the
incidence of VAP and the length of ICU stay, but, again, the evidence is low
certainty. There is insufficient evidence to determine whether any of the
interventions evaluated in the studies are associated with adverse effects.
AN - rayyan-563560063
AU - Zhao, T.
AU - Wu, X.
AU - Zhang, Q.
AU - Li, C.
AU - Hua, F.
DO - 10.1002/14651858.CD008367.pub4
IS - 12
KW - chlorhexidine
gel
bleeding index
caregiver support
critically ill patient
decontamination
economics
gingival index
hospitalization
human
incidence
intensive care unit
mortality
mouth hygiene
numbers needed to treat
periodontal index
plaque index
review
systematic review
tooth brushing
treatment duration
ventilated patient
ventilator associated pneumonia
LA - English
PY - 2020
SN - 1465-1858
ST - Oral hygiene care for critically ill patients to prevent ventilator-
associated pneumonia
T2 - Cochrane Database Syst. Rev.
TI - Oral hygiene care for critically ill patients to prevent ventilator-
associated pneumonia
VL - 2020
ID - 13437
ER -
TY - JOUR
AB - The clinical management of chronic periodontitis with diabetes mellitus
(CPDM) is a long-standing thorny issue. The excessive production of reactive oxygen
species (ROS) is one of the important implications in CPDM. In the present study,
oxidized dextran (OD) and phenylboronic acid-functionalized poly (ethylene imine)
(PBA-PEI) were used to develop a novel injectable local drug delivery system (LDDS)
which could simultaneously improve drug loading efficiency (doxycycline (Doxy) and
metformin (Met)) through B-N coordination and achieve ROStriggered drug release
locally. The injectable LDDS exhibited appropriate adhesiveness to gingival tissue,
good biocompatibility, and remarkable antibacterial effect against S. aureus, E.
coli, and P. gingivalis. Furthermore, the favorable synergistic effect of Doxy and
Met was also verified in vivo in a CPDM rat model through the morphometry and
histological observations of alveolar bone, immunohistochemistry staining, and the
detection of the expression level of immune-inflammatory mediators in gingival
tissue. The results show that the double drug-loaded PBA-PEI/OD hydrogel, as a
novel promising therapeutic agent, may be a favorable potential candidate for the
CPDM management in the dental clinic.
AN - rayyan-563562261
AU - Zhao, X. D.
AU - Yang, Y. X.
AU - Yu, J.
AU - Ding, R.
AU - Pei, D. D.
AU - Zhang, Y. F.
AU - He, G.
AU - Cheng, Y. L.
AU - Li, A.
PY - 2022
SN - ["0142-9612", "1878-5905"]
ST - Injectable hydrogels with high drug loading through B-N coordination and ROS-
triggered drug release for efficient treatment of chronic periodontitis in diabetic
rats
T2 - BIOMATERIALS
TI - Injectable hydrogels with high drug loading through B-N coordination and ROS-
rats
VL - 282
Y2 - 3
ID - 15635
ER -
TY - JOUR
metformin (Met)) through B-N coordination and achieve ROS-triggered drug release
AN - rayyan-563560792
AU - Zhao, X.
AU - Yang, Y.
AU - Yu, J.
AU - Ding, R.
AU - Pei, D.
AU - Zhang, Y.
AU - He, G.
AU - Cheng, Y.
AU - Li, A.
J2 - Biomaterials
KW - Animals
*Chronic Periodontitis
*Diabetes Mellitus, Experimental/drug therapy
Doxycycline
Drug Liberation
Escherichia coli/metabolism
Hydrogels
Rats
Reactive Oxygen Species/metabolism
Staphylococcus aureus/metabolism
LA - eng
N1 - Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine
Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710049, China.;
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,
College of Stomatology, Xi'an Jiaotong University, Xi'an, 710049, China.; School of
Chemistry, Xi'an Jiaotong University, Xi'an, 710049, China.; Key Laboratory of
Shaanxi Province for Craniofacial Precision Medicine Research, College of
Stomatology, Xi'an Jiaotong University, Xi'an, 710049, China.; Key Laboratory of
Shaanxi Province for Craniofacial Precision Medicine Research, College of
Stomatology, Xi'an Jiaotong University, Xi'an, 710049, China.; School of Chemistry,
Xi'an Jiaotong University, Xi'an, 710049, China.; Frontier Institute of Science and
Technology, Xi'an Jiaotong University, Xi'an, 710049, China.; School of Chemistry,
Xi'an Jiaotong University, Xi'an, 710049, China. Electronic address:
yilongcheng@xjtu.edu.cn.; Key Laboratory of Shaanxi Province for Craniofacial
Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University,
Xi'an, 710049, China. Electronic address: drliang@mail.xjtu.edu.cn.
PY - 2022
SP - 121387
ST - Injectable hydrogels with high drug loading through B-N coordination and ROS-
rats
T2 - Biomaterials
TI - Injectable hydrogels with high drug loading through B-N coordination and ROS-
rats
VL - 282
Y2 - 3
ID - 14166
ER -
TY - JOUR
metformin (Met)) through B–N coordination and achieve ROS-triggered drug release
AN - rayyan-563559897
AU - Zhao, X.
AU - Yang, Y.
AU - Yu, J.
AU - Ding, R.
AU - Pei, D.
AU - Zhang, Y.
AU - He, G.
AU - Cheng, Y.
AU - Li, A.
KW - autacoid
benzeneboronic acid
dextran derivative
doxycycline
hydrogel
messenger RNA
metformin
oxidized dextran
polyethyleneimine
unclassified drug
alveolar bone
animal cell
animal experiment
animal model
animal tissue
article
biocompatibility
controlled study
dental clinic
diabetes mellitus
drug design
drug loading
drug release
drug safety
drug synthesis
Escherichia coli
flow kinetics
gingival tissue
histopathology
in vitro study
in vivo study
male
molecular interaction
morphometry
mouse
nonhuman
osteolysis
oxidative stress
protein expression
rat
rat model
synergistic effect
tissue adhesion
LA - English
PY - 2022
SN - ["1878-5905", "0142-9612"]
ST - Injectable hydrogels with high drug loading through B–N coordination and ROS-
rats
T2 - Biomaterials
TI - Injectable hydrogels with high drug loading through B–N coordination and ROS-
rats
VL - 282
ID - 13271
ER -
TY - JOUR
AB - Background: Clinical efficacy of antimicrobial photodynamic therapy (aPDT) as
compared to antibiotics in periodontitis and peri-implantitis has been tested in
several clinical trials. Yet controversial results were reported. The aim of the
present study was to answer the question: “Will adjunctive antimicrobial
photodynamic therapy be more effective than antibiotics agent in the treatment of
periodontitis and peri-implantitis?”. Methods: Publications compared outcomes
between aPDT and antibiotics in adult patients with periodontitis or peri-
implantitis, containing more than 3-month follow-up duration, were involved in the
systematic review and meta-analysis. PubMed, EMBASE and Cochrane Central were
searched until December of 2020. Clinical parameters including pocket probing depth
(PPD), clinical attachment level (CAL), and bleeding on probing (BOP) were
evaluated. The risk of bias was assessed by Cochrane Collaboration Tool. Weighted
mean differences (WMD), 95 % confidence interval(CI) and heterogeneity were
estimated by Review Manager software. Results: 10 trials in periodontitis and 5
trials in peri-implantitis were included. Meta-analysis outcomes revealed equal
clinical evidence for aPDT and antibiotics in periodontitis and peri-implantitis.
In addition, aPDT significantly reduced the red complex in both diseases. However,
owing to the heterogeneity of protocols in articles and the limited number of
studies, the comparative conclusion remained unconfirmed. Conclusion: aPDT can be
considered as an alternative to antibiotics in the treatment of peri-implantitis
and periodontitis. Given that high heterogeneity in outcome was found in this
review, future long-term clinical trials with standard aPDT and antibiotic
treatment should be tested to arrive at a firm conclusion.
AN - rayyan-563559986
AU - Zhao, Y.
AU - Pu, R.
AU - Qian, Y.
AU - Shi, J.
AU - Si, M.
DO - 10.1016/j.pdpdt.2021.102231
KW - amoxicillin
antibiotic agent
bactericide
chlorhexidine
clarithromycin
gel
indocyanine green
methylene blue
metronidazole
microsphere
minocycline
phenothiazine
simvastatin
adult
antibiotic therapy
bleeding
clinical outcome
dental debridement
dental scaling
follow up
human
meta analysis
nonhuman
periimplantitis
periodontitis
priority journal
review
root planing
Salvadora persica
suppuration
systematic review
Treponema denticola
ultrasonic periodontal debridement
ultrasound therapy
LA - English
PY - 2021
SN - ["1873-1597", "1572-1000"]
ST - Antimicrobial photodynamic therapy versus antibiotics as an adjunct in the
treatment of periodontitis and peri-implantitis: A systematic review and meta-
analysis
TI - Antimicrobial photodynamic therapy versus antibiotics as an adjunct in the
treatment of periodontitis and peri-implantitis: A systematic review and meta-
analysis
VL - 34
ID - 13360
ER -
TY - JOUR
AB - Periodontitis is a chronic inflammatory disease affecting teeth, periodontal
ligament and alveolar bone. Current treatment options include surgery or oral
antibiotics. Oral dosage forms shows systemic side effects due to frequent dosing
and it failed to reach the therapeutic concentration in the periodontal cavity. In
this work, a novel in situ gel loaded with azithromycin laden lipid liquid-
crystalline nanoparticles (cubosomes) was formulated for effective treatment of
periodontitis. Cubosomes were prepared using DL-alpha-nnonoolein (MO) and Pluronic
(R) F-I27, and characterized for size, zeta potential, shape, and entrapment
efficacy. In situ gel laden cubosomes were evaluated for pH, drug content,
viscosity, syringeability, mucoadhesive strength, texture profile, gelation
temperature, gel strength, in vitro release profile, antimicrobial activity and in
vivo efficacy in rat model. Cubosomal size (137-450 nm) and entrapment efficacy
(74-88%) increases with increase in the level of MO. The in situ gel-cubosomal
batches showed sufficient viscosity (878-956 cp), syringeability (125-150N),
mucoadhesive strength (25.7-26.2 dyne/cm(2)), gelation temperature (34.3-35.3
degrees C), gel strength (45-51 s), and texture profile for periodontal
application. The in vitro release profiles showed sustain azithromycin release for
24h from the in situ gel-cubosomal gels compared to 4h from the marketed
azithromycin gel. The in vivo studies (alveolar bone loss and histopathology) in
rat model confirmed the efficacy of in situ gel to treat periodontitis at low
frequency of dosing compared to marketed gel. In conclusion, the study demonstrated
the potential of cubosomes to sustain the release of azithromycin from in situ
gelling system for effective treatment of periodontitis.
AN - rayyan-563562161
AU - Zheng, J.
AU - Zhang, Y. W.
AU - Zhang, S. X.
DO - 10.1177/08853282221095395
IS - 3
PY - 2022
SN - ["0885-3282", "1530-8022"]
SP - 482-492
ST - Sustained release of azithromycin from lipid liquid-crystalline nanoparticles
laden in situ gel for the treatment of periodontitis: In vitro and efficacy study
T2 - JOURNAL OF BIOMATERIALS APPLICATIONS
TI - Sustained release of azithromycin from lipid liquid-crystalline nanoparticles
VL - 37
Y2 - 9
ID - 15535
ER -
TY - JOUR
AB - Periodontitis is a chronic inflammatory disease affecting teeth, periodontal
ligament and alveolar bone. Current treatment options include surgery or oral
antibiotics. Oral dosage forms shows systemic side effects due to frequent dosing
and it failed to reach the therapeutic concentration in the periodontal cavity. In
this work, a novel in situ gel loaded with azithromycin laden lipid liquid-
crystalline nanoparticles (cubosomes) was formulated for effective treatment of
periodontitis. Cubosomes were prepared using DL-α-monoolein (MO) and Pluronic®F-
127, and characterized for size, zeta potential, shape, and entrapment efficacy. In
situ gel laden cubosomes were evaluated for pH, drug content, viscosity,
syringeability, mucoadhesive strength, texture profile, gelation temperature, gel
strength, in vitro release profile, antimicrobial activity and in vivo efficacy in
rat model. Cubosomal size (137–450 nm) and entrapment efficacy (74–88%) increases
with increase in the level of MO. The in situ gel-cubosomal batches showed
sufficient viscosity (878–956 cp), syringeability (125–150N), mucoadhesive strength
(25.7–26.2 dyne/cm2), gelation temperature (34.3–35.3oC), gel strength (45–51 s),
and texture profile for periodontal application. The in vitro release profiles
showed sustain azithromycin release for 24h from the in situ gel-cubosomal gels
compared to 4h from the marketed azithromycin gel. The in vivo studies (alveolar
bone loss and histopathology) in rat model confirmed the efficacy of in situ gel to
treat periodontitis at low frequency of dosing compared to marketed gel. In
conclusion, the study demonstrated the potential of cubosomes to sustain the
release of azithromycin from in situ gelling system for effective treatment of
periodontitis.
AN - rayyan-563559806
AU - Zheng, J.
AU - Zhang, Y.
AU - Zhang, S.
DO - 10.1177/08853282221095395
IS - 3
KW - azithromycin
gel
lipid
nanoparticle
alveolar bone
alveolar bone loss
animal experiment
animal model
article
cell infiltration
chemical reaction kinetics
clinical article
dispersity
drug efficacy
drug release
histopathology
human
in vitro study
male
microbial activity
microscopy
nonhuman
particle size
periodontal disease
periodontitis
pH
rat
scoring system
ultrasound
viscosity
visual analog scale
zeta potential
LA - English
PY - 2022
SN - ["1530-8022", "0885-3282"]
SP - 482-492
ST - Sustained release of azithromycin from lipid liquid-crystalline nanoparticles
TI - Sustained release of azithromycin from lipid liquid-crystalline nanoparticles
VL - 37
ID - 13180
ER -
TY - JOUR
AB - Introduction: Periodontitis is a chronic inflammatory disease brought on by
various bacteria, and effective antibacterial, anti-inflammatory and alveolar bone
regeneration are the main goals of treating periodontal disease. Methods: In the
current work, we employed Icariin (ICA) into a hydrogel modified with carbon
nanofiber (CNF) to create a multifunctional composite nanoplatform. The composite
was activated in the near infrared (NIR) to treat periodontitis. Results: The
antibacterial results showed that the ICA+CNF@H showed 94.2% and 91.7% clearance of
S. aureus and E. coli, respectively, under NIR irradiation. In vitro experiments
showed that NIR-irradiated composites suppressed inflammatory factor (IL-6) and ROS
expression and up-regulated the performance of antiinflammatory factor (IL-10) in
RAW264.7 cells. At the same time, the composites promoted the production of
osteogenic factors in BMSCs, with an approximately 3-fold increase in alkaline
phosphatase activity after 7 days and an approximately 2-fold increase in the rate
of extracellular matrix mineralization after 21 days. In vivo tests showed that the
alveolar bone height was clearly greater in the ICA+CNF@H (NIR) group compared to
the periodontitis group. Discussion: In conclusion, ICA+CNF@H under NIR irradiation
achieved a synergistic effect of antibacterial, anti-inflammatory, reduction of
reactive oxygen species and promotion of osteogenesis, offering a novel approach
for treating periodontitis.
AN - rayyan-563562192
AU - Zheng, X. J.
AU - Dong, Z. Q.
AU - Liang, Z. P.
AU - Liu, Y.
AU - Yin, X. W.
AU - Han, M. F.
AU - Cui, Z. C.
AU - Mei, X. F.
AU - Gao, X. Q.
DO - 10.3389/fbioe.2023.1207011
PY - 2023
SN - 2296-4185
ST - Photothermally responsive icariin and carbon nanofiber modified hydrogels for
T2 - FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
TI - Photothermally responsive icariin and carbon nanofiber modified hydrogels for
VL - 11
Y2 - 5 y3 - 16
ID - 15566
ER -
TY - JOUR
AB - Introduction: Periodontitis is a chronic inflammatory disease brought on by
various bacteria, and effective antibacterial, anti-inflammatory and alveolar bone
regeneration are the main goals of treating periodontal disease. Methods: In the
current work, we employed Icariin (ICA) into a hydrogel modified with carbon
nanofiber (CNF) to create a multifunctional composite nanoplatform. The composite
was activated in the near infrared (NIR) to treat periodontitis. Results: The
antibacterial results showed that the ICA+CNF@H showed 94.2% and 91.7% clearance of
S. aureus and E. coli, respectively, under NIR irradiation. In vitro experiments
showed that NIR-irradiated composites suppressed inflammatory factor (IL-6) and ROS
expression and up-regulated the performance of anti-inflammatory factor (IL-10) in
RAW264.7 cells. At the same time, the composites promoted the production of
osteogenic factors in BMSCs, with an approximately 3-fold increase in alkaline
phosphatase activity after 7 days and an approximately 2-fold increase in the rate
of extracellular matrix mineralization after 21 days. In vivo tests showed that the
alveolar bone height was clearly greater in the ICA+CNF@H (NIR) group compared to
the periodontitis group. Discussion: In conclusion, ICA+CNF@H under NIR irradiation
achieved a synergistic effect of antibacterial, anti-inflammatory, reduction of
reactive oxygen species and promotion of osteogenesis, offering a novel approach
for treating periodontitis.
AN - rayyan-563561108
AU - Zheng, X.
AU - Dong, Z.
AU - Liang, Z.
AU - Liu, Y.
AU - Yin, X.
AU - Han, M.
AU - Cui, Z.
AU - Mei, X.
AU - Gao, X.
DO - 10.3389/fbioe.2023.1207011
J2 - Front Bioeng Biotechnol
LA - eng
N1 - Jinzhou Medical University, Jinzhou, China.; Jinzhou Medical University,
Jinzhou, China.; Jinzhou Medical University, Jinzhou, China.; Jinzhou Medical
University, Jinzhou, China.; Jinzhou Medical University, Jinzhou, China.; Jinzhou
Medical University, Jinzhou, China.; Jinzhou Medical University, Jinzhou, China.;
Jinzhou Medical University, Jinzhou, China.; Jinzhou Medical University, Jinzhou,
China.
PY - 2023
SN - 2296-4185 (Print)
SP - 1207011
ST - Photothermally responsive icariin and carbon nanofiber modified hydrogels for
T2 - Frontiers in bioengineering and biotechnology
TI - Photothermally responsive icariin and carbon nanofiber modified hydrogels for
VL - 11
ID - 14482
ER -
TY - JOUR
AB - Background: In the last decade the incidence of periodontal disease has
increased many times, and, according to data from WHO, it has become a global
problem. In Russia 98.5% of those examined have periodontal disease. Currently,
there is a shortage of locally produced medical remedies for the treatment of
periodontal diseases. This situation creates a need for their pharmaceutical
development. Aim: To study the antimicrobialactivity of model gel mixtures for
dental use, with juniper essential oil as the final stage, in the development of a
new soft dosage form for dental use. Materials and methods: Model samples of gel
with apple pectin and gel with carbomer 934 were obtained. Antimicrobial activity
was determined according to GPI.1.2.4.0010.18 “Determination of the antimicrobial
activity of antibiotics by agar diffusion”. Results: All samples showed an
acceptable degree of antimicrobial activity, however developed gel samples turned
out to be priority in comparison with the market drug. Conclusion: It was
established that the developed samples have moderate and high antibacterial
activity in relation to the studied microorganism strains and a more pronounced
biocidal effect than the reference drug – Metrogil-Dent gel.
AN - rayyan-563560128
AU - Zhilyakova, E. T.
AU - Lysykh, E. G.
AU - Novikov, O. O.
AU - Malyutina, A. Y.
AU - Pisarev, D. I.
AU - Zolotareva, L. V.
DO - 10.31838/ijpr/2020.12.02.210
IS - 2
KW - benzalkonium chloride
carbomer
essential oil
pectin
agar diffusion
article
biocidal activity
colony forming unit
drug dealing
drug marketing
flow kinetics
Juniperus
nonhuman
physical chemistry
phytochemistry
zone of inhibition
LA - English
PY - 2020
SN - 0975-2366
SP - 1663-1666
ST - Results of study dealing with antimicrobial activity of model gel mixtures
for dental use with juniper essential oil
TI - Results of study dealing with antimicrobial activity of model gel mixtures
for dental use with juniper essential oil
VL - 12
ID - 13502
ER -
TY - JOUR
AB - The modern range of products for cure of parodont diseases is mostly
represented by liquid medical forms (solutions, tinctures, liquid spirit extracts)
and by ointments and gels. The largest number of advantages belongs to medical
forms such as hydrophilic gels due to their ability to reduce the puffiness, to be
well-distributed on the mucous membrane creating the local therapeutic
concentrations, and their use is convenient. Nowadays the market of Russian
Federation is represented by gels, which basis are the rare-stitched acrylic
polymers, ethers of cellulose and soluble recipients. Among them no natural bases
were identified and in particular, the pectin. In pharmaceutical technology, apple
pectin is the most commonly used natural thickener. The apple pectin is a complex
ether of methanol and pectic acid. Many important properties belong to apple pectin
which can be explained by presence of the free carboxyl and hydrocarboxyl groups
from galacturonic acid. This article provides the results of the technology
development of gel based on apple pectin. Physical, chemical and consumers
properties of the gel were also studied in the framework of this article.
AN - rayyan-563560277
AU - Novikov, O. O.
AU - Lysykh, E. G.
AU - Zalivskaya, A. V.
KW - carboxyl group
essential oil
galacturonic acid
methanol
pectin
terpene
article
blood rheology
cell membrane
chemical phenomena
conceptual framework
consumer
dental procedure
gel
heating
inflammation
internal consistency
Juniperus
kinematics
medicinal chemistry
mouth mucosa
ointment
periodontal disease
pH
physical chemistry
research
technology
temperature
LA - English
PY - 2018
SN - 1674-0440
SP - 416-419
ST - Study of physical, chemical and consumer properties for development of dental
gel basis aimed to cure of parodont diseases
T2 - J. Int. Pharm. Res.
TI - Study of physical, chemical and consumer properties for development of dental
gel basis aimed to cure of parodont diseases
VL - 45
ID - 13651
ER -
TY - JOUR
AB - Currently, the problem of prevention and treatment of periodontal diseases is
highly relevant and has a medical and social importance because of its high
prevalence. According to WHO, nearly 95% of the world's adult population and 80% of
children have symptoms of the disease. Periodontal diseases are multifactorial,
based on microbial aggression. Therefore, drugs should have, first of all, the
antibacterial effect and, given the accompanying phenomena, antiinflammatory and
analgesic effect, and shall accelerate tissue regeneration, i.e. should be the
combination products. To date, the range of drugs for the treatment of gingivitis
is represented by different dosage forms, including gels. This paper is
particularly focused on a component of dental gels - the bases. The paper presents
the analysis of searches for the bases for a dental gel among the cellulose
derivatives.
AN - rayyan-563560324
AU - Novikov, O. O.
AU - Novikova, M. Y.
AU - Krikun, E. N.
AU - Klyueva, V. V.
AU - Zalivskaya, A. V.
IS - 4
KW - agar
dental material
polymer
article
Aspergillus
bacterial growth
nonhuman
Penicillium
surface property
LA - English
PY - 2016
SN - 0975-766X
SP - 26785-26794
ST - Search results of an optimal composition of the basis for dental gel among
the cellulose derivatives
T2 - Intl. J. Pharm. Technol.
TI - Search results of an optimal composition of the basis for dental gel among
the cellulose derivatives
VL - 8
ID - 13698
ER -
TY - JOUR
AB - To investigate the degradation effect of bovine trypsin on multispecies
biofilm of periodontitis-related bacteria and to provide an experimental reference
for exploring new methods for controlling biofilms of periodontitis-related
microorganisms, the multispecies biofilm of periodontitis-related microorganisms
was established. Standard strains of Porphyromonas gingivalis, Fusobacterium
nucleatum subsp. polymorpha, Actinomyces viscosus, and Aggregatibacter
actinomycetemcomitans were co-cultured to form the biofilm. The experimental groups
were treated with bovine trypsin, distilled water was applied as the blank control
group, and phosphate saline buffer (pH = 7.4) as the negative control group.
Morphological observation and quantitative analysis of extracellular polymeric
substances (EPS), live bacteria, and dead bacteria were conducted using a laser
confocal microscope. The morphological changes of EPS and bacteria were also
observed using a scanning electron microscope. The results of morphological
observations of modeling were as follows. EPS aggregated as agglomerates, and
bacteria flora were wrapped by them, showing a three-dimensional network structure,
and channel-like structures were inside the biofilm. Live bacteria were distributed
on the surface of the EPS or embedded in them, dead bacteria aggregated between
live flora and the bottom layer of biofilms. After being treated with bovine
trypsin, the three-dimensional network structure and the channel-like structure
disappeared, and the EPS and live and dead bacteria decreased. Quantitative
analysis results are as follows. When biofilm was treated for 30 s, 1 min, and 3
min, the minimum effective concentrations of bovine trypsin to reduce EPS were 2
mg/ml (P < 0.05), 0.5 mg/ml (P < 0.05), and 0.25 mg/ml (P < 0.05), respectively.
The minimum effective concentrations of bovine trypsin to reduce the live or dead
bacteria were 2 mg/ml (P < 0.05), 0.5 mg/ml (P < 0.05), and 0.5 mg/ml (P < 0.05),
respectively. There was no significant difference in the ratio of live/dead
bacteria after the biofilm was treated for 30 s with bovine trypsin at the
concentration of 0.25, 0.5, 1, and 2 mg/ml (P > 0.05), and the minimum effective
concentration to reduce the ratio of live bacteria/dead bacteria was 0.25 mg/ml (P
< 0.05) after treatment for 1 min and 3 min. Therefore, bovine trypsin can destroy
biofilm structure, disperse biofilm and bacteria flora, and reduce the EPS and
bacterial biomass, which are positively correlated with the application time and
concentration.
AN - rayyan-563559813
AU - Zhou, J.
AU - Meng, X.
AU - Han, Q.
AU - Huang, Y.
AU - Huo, L.
AU - Lei, Y.
DO - 10.3389/fmicb.2022.951291
KW - BacLight
Brain Heart Infusion broth
incubator
liquid culture
microwell plate
mounting medium
alexa fluor
F actin
glutaraldehyde
hydrogel
trypsin
Actinomyces
article
bacterial viability
bacterium culture
biofilm
biomass
bovine
colony forming unit
controlled study
degradation
in vitro study
microorganism
minimum effective concentration
nonhuman
periodontitis
LA - English
PY - 2022
SN - 1664-302X
ST - An in vitro study on the degradation of multispecies biofilm of
periodontitis-related microorganisms by bovine trypsin
TI - An in vitro study on the degradation of multispecies biofilm of
periodontitis-related microorganisms by bovine trypsin
VL - 13
ID - 13187
ER -
TY - JOUR
AB - Periodontitis is a common disease that causes periodontium defects and tooth
loss. Controlling inflammation and tissue regeneration are two key strategies in
the treatment of periodontitis. Tetrahedral framework nucleic acids can modulate
multiple biological behaviors, and thus, their biological applications have been
widely explored. In this study, we investigated the effect of tFNAs on periodontium
under inflammatory conditions. Lipopolysaccharide and silk ligature were used to
induce inflammation in vivo and in vitro. The results displayed that tFNAs
decreased the release of pro-inflammatory cytokines and levels of cellular reactive
oxygen species in periodontal ligament stem cells, which promoted osteogenic
differentiation. Furthermore, animal experiments showed that tFNAs ameliorated the
inflammation of the periodontium and protect periodontal tissue, especially
reducing alveolar bone absorption by decreasing inflammatory infiltration and
inhibiting osteoclast formation. These findings suggest that tFNAs can
significantly improve the therapeutic effect of periodontitis and have the great
potential significance in the field of periodontal tissue regeneration.
AN - rayyan-563559985
AU - Zhou, M.
AU - Gao, S.
AU - Zhang, X.
AU - Zhang, T.
AU - Tian, T.
AU - Li, S.
AU - Lin, Y.
AU - Cai, X.
DO - 10.1016/j.bioactmat.2020.11.018
IS - 6
KW - A1R MP
CT scanner
conditioned medium
PCR assay kit
SCANCO
particle size analyzer
interleukin 1beta
interleukin 6
lipopolysaccharide
malonaldehyde
nucleic acid
osteopontin
parkin
silk
tetrahedral framework nucleic acid
transcription factor Sox9
unclassified drug
animal cell
animal experiment
animal model
antioxidant assay
article
bone density
cell infiltration
cell migration
controlled study
gene expression
histology
immunofluorescence
in vitro study
in vivo study
inflammation
ion trap mass spectrometry
male
MAPK signaling
nonhuman
osteoclastogenesis
oxidative stress
periodontitis
periodontium
protection
protein expression
rat
tissue regeneration
Western blotting
wound healing assay
Zetasizer Nano ZS90
LA - English
PY - 2021
SN - 2452-199X
SP - 1676-1688
ST - The protective effect of tetrahedral framework nucleic acids on periodontium
under inflammatory conditions
T2 - Bioact. Mater.
TI - The protective effect of tetrahedral framework nucleic acids on periodontium
under inflammatory conditions
VL - 6
ID - 13359
ER -
TY - JOUR
AB - A variety of novel biomaterials have recently been developed to promote bone
regeneration. However, the current biomaterials cannot accurately and effectively
resist bacterial invasion. In this study, we constructed microspheres that mimic
certain functions of macrophages as additives to bone repair materials, which can
be manipulated as demanded to resist bacteria effectively and protect bone defect
healing. Firstly, we prepared gelatin microspheres (GMSs) by an emulsion-
crosslinking method, which were subsequently coated with polydopamine (PDA). Then,
amino antibacterial nanoparticles obtained by a nanoprecipitation-self-assembly
method and commercial amino magnetic nanoparticles were modified onto these PDA-
coated GMSs to construct the functionalized microspheres (FMSs). The results showed
that the FMSs possessed a rough topography and could be manipulated by a 100-400 mT
static magnetic field to migrate directionally in unsolidified hydrogels. Moreover,
in vitro experiments with near-infrared (NIR) showed that the FMSs had a sensitive
and recyclable photothermal performance and could capture and kill Porphyromonas
gingivalis by releasing reactive oxygen species. Finally, the FMSs were mixed with
osteogenic hydrogel precursor, injected into the Sprague-Dawley rat periodontal
bone defect of maxillary first molar (M1), and subsequently driven by magnetism to
the cervical surface of M1 and the outer surface of the gel system for targeted
sterilization under NIR, thus protecting the bone defect healing. In conclusion,
the FMSs had excellent manipulation and antimicrobial performances. This provided
us with a promising strategy to construct light-magnetism-responsive antibacterial
materials to build a beneficial environment for bone defect healing.
AN - rayyan-563562356
AU - Zhou, Q.
AU - Liu, J.
AU - Yan, J.
AU - Guo, Z. B.
AU - Zhang, F. M.
DO - 10.1016/j.mtbio.2023.100651
PY - 2023
SN - 2590-0064
ST - Magnetic microspheres mimicking certain functions of macrophages: Towards
precise antibacterial potency for bone defect healing
TI - Magnetic microspheres mimicking certain functions of macrophages: Towards
VL - 20
Y2 - 6
ID - 15730
ER -
TY - JOUR
AB - A variety of novel biomaterials have recently been developed to promote bone
regeneration. However, the current biomaterials cannot accurately and effectively
resist bacterial invasion. In this study, we constructed microspheres that mimic
certain functions of macrophages as additives to bone repair materials, which can
be manipulated as demanded to resist bacteria effectively and protect bone defect
healing. Firstly, we prepared gelatin microspheres (GMSs) by an emulsion-
crosslinking method, which were subsequently coated with polydopamine (PDA). Then,
amino antibacterial nanoparticles obtained by a nanoprecipitation-self-assembly
method and commercial amino magnetic nanoparticles were modified onto these PDA-
coated GMSs to construct the functionalized microspheres (FMSs). The results showed
that the FMSs possessed a rough topography and could be manipulated by a 100-400 mT
static magnetic field to migrate directionally in unsolidified hydrogels. Moreover,
in vitro experiments with near-infrared (NIR) showed that the FMSs had a sensitive
and recyclable photothermal performance and could capture and kill Porphyromonas
gingivalis by releasing reactive oxygen species. Finally, the FMSs were mixed with
osteogenic hydrogel precursor, injected into the Sprague-Dawley rat periodontal
bone defect of maxillary first molar (M1), and subsequently driven by magnetism to
the cervical surface of M1 and the outer surface of the gel system for targeted
sterilization under NIR, thus protecting the bone defect healing. In conclusion,
the FMSs had excellent manipulation and antimicrobial performances. This provided
us with a promising strategy to construct light-magnetism-responsive antibacterial
materials to build a beneficial environment for bone defect healing.
AN - rayyan-563561329
AU - Zhou, Q.
AU - Liu, J.
AU - Yan, J.
AU - Guo, Z.
AU - Zhang, F.
DO - 10.1016/j.mtbio.2023.100651
LA - eng
N1 - Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing,
210029, China.; Department of Prosthodontics, Affiliated Hospital of Stomatology,
Nanjing Medical University, Nanjing, 210029, China.; Jiangsu Province Engineering
Research Center of Stomatological Translational Medicine, Nanjing, 210029, China.;
Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing,
210029, China.; Jiangsu Province Engineering Research Center of Stomatological
Translational Medicine, Nanjing, 210029, China.; Nanjing Stomatological Hospital,
Medical School of Nanjing University, Nanjing, 210008, China.; Jiangsu Key
Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China.;
Department of Prosthodontics, Affiliated Hospital of Stomatology, Nanjing Medical
University, Nanjing, 210029, China.; Jiangsu Province Engineering Research Center
of Stomatological Translational Medicine, Nanjing, 210029, China.; Institute for
Nanobiotechnology, Johns Hopkins University, Baltimore, MD, 21218, USA.; Jiangsu
Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029,
China.; Department of Prosthodontics, Affiliated Hospital of Stomatology, Nanjing
Medical University, Nanjing, 210029, China.; Jiangsu Province Engineering Research
Center of Stomatological Translational Medicine, Nanjing, 210029, China.
PY - 2023
SP - 100651
ST - Magnetic microspheres mimicking certain functions of macrophages: Towards
TI - Magnetic microspheres mimicking certain functions of macrophages: Towards
VL - 20
Y2 - 6
ID - 14703
ER -
TY - JOUR
AN - rayyan-563561547
AU - Zhu, Y.
AU - Tao, C.
AU - Goh, C.
AU - Shrestha, A.
DO - 10.3389/fdmed.2023.1163562
PY - 2023
ST - Innovative biomaterials for the treatment of periodontal disease
T2 - Frontiers in Dental Medicine
TI - Innovative biomaterials for the treatment of periodontal disease
85161974402&doi=10.3389%2ffdmed.2023.1163562&partnerID=40&md5=ea78bc574648f9070a6e3
a2f93addf35
VL - 4
ID - 14921
ER -
TY - JOUR
AB - BACKGROUND: Carvacrol is a natural plant extract that acts as a substitute of
antibiotics and has a good prospect because of its antibacterial activity, low drug
resistance and low cytotoxicity. OBJECTIVE: To review the antibacterial activity
and clinical applications of carvacrol in the prevention and treatment of common
oral diseases. METHODS: PubMed and CNKI database were searched by computer using
the keywords of “carvacrol, antibacterial, oral, osteogenesis” in English and
Chinese, respectively. The retrieval period was from January 2011 to June 2021.
Preliminary screening of literature was conducted through reading and analysis to
exclude duplicate and low-correlation literature. Finally, 49 articles were
included for result analysis. RESULTS AND CONCLUSION: Experimental results have
shown that carvacrol exerts significant antibacterial effects on the pathogens and
bacterial biofilms of various common oral diseases, such as dental caries, oral
candidiasis, periodontitis and peri-implantitis. The combined use of carvacrol and
antibiotics produces a synergistic effect, which can enhance curative effect and
reduce drug resistance. Even at high concentrations, carvacrol can still maintain
low cytotoxicity and good safety. In addition, carvacrol can inhibit osteoclast
differentiation, help repair bone defects and reduce bone destruction, which can be
used in bone tissue engineering. Considering the above biological characteristics,
carvacrol can be added into antibacterial drugs, biological barrier films and
mouthwashes, which can be used in the clinical treatment of oral diseases.
AN - rayyan-563559804
AU - Zihan, Z.
AU - Wenli, W.
AU - Jinnuo, L.
AU - Yourui, L.
DO - 10.12307/2022.831
IS - 26
carvacrol
essential oil
mouthwash
article
biofilm
bone defect
bone destruction
bone development
bone remodeling
cytotoxicity
dental caries
human
mouth disease
nonhuman
osteoclastogenesis
periimplantitis
periodontitis
synergistic effect
systematic review
thrush
tissue engineering
LA - Chinese
PY - 2022
SN - 2095-4344
SP - 4252-4257
ST - Carvacrol: antibacterial activity, bone repair, and prevention and treatment
in oral diseases
TI - Carvacrol: antibacterial activity, bone repair, and prevention and treatment
in oral diseases
VL - 26
ID - 13178
ER -
TY - JOUR
AN - rayyan-563561218
AU - Zinner, D. D.
AU - Duany, L. F.
AU - Chilton, N. W.
IS - 1
article
dentistry
gel
gingivitis
tooth plaque
LA - English
PY - 1970
SN - 0001-4389
SP - 7-15
ST - Controlled study of the clinical effectiveness of a new oxygen gel on plaque,
oral debris and gingival inflammation
T2 - Pharmacol Ther Dent
TI - Controlled study of the clinical effectiveness of a new oxygen gel on plaque,
oral debris and gingival inflammation
VL - 1
ID - 14592
ER -
TY - JOUR
AB - The antimicrobial activity of taurolidine was compared with minocycline
against microbial species associated with periodontitis (four single strains and a
12-species mixture). Minimal inhibitory concentrations (MICs) and minimal
bactericidal concentrations (MBCs), killing as well as activities on established
and forming single-species biofilms and a 12-species biofilm were determined. The
MICs of taurolidine against single species were always 0.31 mg/ml, the MBCs were
0.64 mg/ml. The used mixed microbiota was less sensitive to taurolidine, MIC and
the MBC was 2.5 mg/ml. The strains and the mixture were completely killed by 2.5
mg/ml taurolidine, whereas 256 mu g/ml minocycline reduced the bacterial counts of
the mixture by 5 log10 colony forming units (cfu). Coating the surface with 10
mg/ml taurolidine or 256 mu g/ml minocycline prevented completely biofilm formation
of Porphyromonas gingivalis ATCC 33277 but not of Aggregatibacter
actinomycetemcomitans Y4 and the mixture. On 4.5 d old biofilms, taurolidine acted
concentration dependent with a reduction by 5 log10 cfu (P. gingivalis ATCC 33277)
and 7 log10 cfu (A. actinomycetemcomitans Y4) when applying 10 mg/ml. Minocycline
decreased the cfu counts by 1-2 log10 cfu independent of the used concentration.
The reduction of the cfu counts in the 4.5 d old multi-species biofilms was about 3
log10 cfu after application of any minocycline concentration and after using 10
mg/ml taurolidine. Taurolidine is active against species associated with
periodontitis, even within biofilms. Nevertheless a complete elimination of complex
biofilms by taurolidine seems to be impossible and underlines the importance of a
mechanical removal of biofilms prior to application of taurolidine. (C) 2014
AN - rayyan-563562414
AU - Zollinger, L.
AU - Schnyder, S.
AU - Nietzsche, S.
AU - Sculean, A.
AU - Eick, S.
DO - 10.1016/j.anaerobe.2014.11.008
PY - 2015
SN - ["1075-9964", "1095-8274"]
SP - 18-23
ST - In-vitro activity of taurolidine on single species and a multispecies
population associated with periodontitis
T2 - ANAEROBE
TI - In-vitro activity of taurolidine on single species and a multispecies
population associated with periodontitis
VL - 32
Y2 - 4
ID - 15788
ER -
TY - JOUR
AB - Objective: To analyze the antimicrobial activity of photodynamic therapy as
an adjunct to conventional endodontic treatment, particularly against Enterococcus
faecalis. Method and materials: A total of 42 single-rooted teeth obtained from 33
patients with apical periodontitis were included. Sampling was developed in three
stages: (1) immediately after accessing the root canal, (2) after chemical and
mechanical instrumentation, and finally, (3) after photodynamic therapy
application. The bacterial load of each sample was quantified by seeding on blood
agar plates and selective M-Enterococcus agar. All growing colonies were identified
using MALDI-TOF (Bruker; matrix-assisted laser desorption/ionization time-of-
flight), and the entire bacterial microbiota composition was determined in the
first sample by PCR-DGGE (polymerase chain reaction denaturing gradient gel
electrophoresis), using 16 rDNA primers and selective nucleotide sequencing.
Results: The endodontic therapy obtained a mean reduction in the cultivable
bacterial load of 1.12 log, whereas the photodynamic therapy combination
significantly increased the bacterial clearance (P < .0001). Viable cells of E
faecalis were detected in 16.6% of root canals, with a mean value of 93 CFU per
tooth, which was reduced to 67 and 9 CFU/tooth after conventional endodontic and
photodynamic therapy treatments, respectively. Molecular E faecalis detection
demonstrated that this species was present in 23.2% of baseline samples. DGGE
analysis demonstrated the existence of a more complex microbiota than those
observed using classical cultures. Conclusion: Photodynamic therapy as an adjunct
to root canal treatment produces a significant reduction in E faecalis bacterial
load, and it should be considered in the prevention of apical periodontitis.
AN - rayyan-563562403
AU - Zorita-Garcia, M.
AU - Alonso-Ezpeleta, L. O.
AU - Cobo, M.
AU - del Campo, R.
AU - Rico-Romano, C.
AU - Mena-Alvarez, J.
AU - Zubizarreta-Macho, A.
DO - 10.3290/j.qi.a43249
IS - 10
PY - 2019
SN - ["0033-6572", "1936-7163"]
SP - 782-789
ST - Photodynamic therapy in endodontic root canal treatment significantly
increases bacterial clearance, preventing apical periodontitis
TI - Photodynamic therapy in endodontic root canal treatment significantly
VL - 50
Y2 - 11
ID - 15777
ER -
TY - JOUR
AB - Objective: To analyze the antimicrobial activity of photodynamic therapy as
an adjunct to conventional endodontic treatment, particularly against Enterococcus
faecalis. Method and materials: A total of 42 single-rooted teeth obtained from 33
patients with apical periodontitis were included. Sampling was developed in three
stages: (1) immediately after accessing the root canal, (2) after chemical and
mechanical instrumentation, and finally, (3) after photodynamic therapy
application. The bacterial load of each sample was quantified by seeding on blood
agar plates and selective M-Enterococcus agar. All growing colonies were identified
using MALDI-TOF (Bruker; matrix-assisted laser desorption/ionization time-of-
flight), and the entire bacterial microbiota composition was determined in the
first sample by PCR-DGGE (polymerase chain reaction denaturing gradient gel
electrophoresis), using 16 rDNA primers and selective nucleotide sequencing.
Results: The endodontic therapy obtained a mean reduction in the cultivable
bacterial load of 1.12 log, whereas the photodynamic therapy combination
significantly increased the bacterial clearance (P < .0001). Viable cells of E
faecalis were detected in 16.6% of root canals, with a mean value of 93 CFU per
tooth, which was reduced to 67 and 9 CFU/tooth after conventional endodontic and
photodynamic therapy treatments, respectively. Molecular E faecalis detection
demonstrated that this species was present in 23.2% of baseline samples. DGGE
analysis demonstrated the existence of a more complex microbiota than those
observed using classical cultures. Conclusion: Photodynamic therapy as an adjunct
to root canal treatment produces a significant reduction in E faecalis bacterial
load, and it should be considered in the prevention of apical periodontitis.
AN - rayyan-563560224
AU - Zorita-García, M.
AU - Alonso-Ezpeleta, L. Ó
AU - Cobo, M.
AU - del Campo, R.
AU - Rico-Romano, C.
AU - Mena-Álvarez, J.
AU - Zubizarreta-Macho, Á
DO - 10.3290/j.qi.a43249
IS - 10
KW - agar medium
FotoSan 630
trocar
agar
DNA 16S
adult
article
bacterial cell
bacterial clearance
bacterial flora
bacterial growth
bacterial load
bacterium colony
clinical article
colony forming unit
drug efficacy
human
nonhuman
normal value
nucleotide sequence
polymerase chain reaction denaturing gradient gel electrophoresis
species composition
tooth root canal
viable cell count
EndoTIP
LA - English
PY - 2019
SN - 0033-6572
SP - 782-789
ST - Photodynamic therapy in endodontic root canal treatment significantly
TI - Photodynamic therapy in endodontic root canal treatment significantly
VL - 50
ID - 13598
ER -
TY - JOUR
AB - Orthodontic tooth movement (OTM) is achieved by using mechanical stimuli,
which lead to the remodeling of periodontal tissues. Previous findings have
demonstrated that autophagy may be one of the cell responses to mechanical stress.
As a key structure in the integrin pathway, integrin linked-kinase (ILK) may play a
role in the transmission of these mechanical signals. In addition, ILK is an
important upstream molecule that regulates autophagy, under the influence of
phosphatidylinositol 3 kinase (PI3K). Therefore, exploring the effect of mechanical
stress on autophagy and the associated role of ILK/PI3K is of utmost significance
to understanding the mechanism behind OTM. In the present study, human periodontal
ligament cells (hPDLCs) were embedded into a collagen-Alginate complex hydrogel for
three-dimensional (3D) culturing. Static compressive stress (2.5 g/cm2) was loaded
using the uniform weight method for 5, 15, 30, and 60 min. The autophagy of hPDLCs
was detected by the expression of Beclin-1 (BECN1) and ATG-5 using RT-qPCR and LC3,
respectively, using immunofluorescence. The results showed that the level of
autophagy and gene expression of ILK increased significantly under static
compressive stress. In ILK-silenced cells, static compressive stress could also
upregulate ILK expression and increase the levels of autophagy. After PI3K
inhibition, the increase in the autophagy level and the upregulation of ILK
expression disappeared. These findings suggest that static compressive stress can
induce autophagy in hPDLCs in a rapid, transient process, regulated by ILK and
PI3K. Moreover, this static stress can upregulate ILK expression in a PI3K-
dependent manner.
AN - rayyan-563559966
AU - Zou, R.
AU - Wu, S.
AU - Wang, Y.
AU - Kang, X.
AU - Zhao, S.
AU - Shi, H.
AU - Zheng, D.
AU - Gao, B.
AU - Ma, S.
AU - Niu, L.
AU - Gao, Y.
DO - 10.3892/ijmm.2021.5000
IS - 3
culture medium
microplate reader
4',6 diamidino 2 phenylindole
alginic acid
autophagy related protein 5
beclin 1
collagen type 1
cytokeratin
dimethyl sulfoxide
dispase
glucose
green fluorescent protein
hexadimethrine bromide
integrin linked kinase
lentivirus vector
protein kinase B
serum albumin
short hairpin RNA
streptomycin
triton x 100
vimentin
animal experiment
animal model
article
autophagosome
controlled study
female
fetal bovine serum
gene expression
human
human cell
immunofluorescence
nonhuman
protein expression
rat
upregulation
Western blotting
LA - English
PY - 2021
SN - ["1791-244X", "1107-3756"]
ST - Role of integrin-linked kinase in static compressive stress-induced autophagy
via phosphatidylinositol 3 kinase in human periodontal ligament cells
T2 - Int. J. Mol. Med.
TI - Role of integrin-linked kinase in static compressive stress-induced autophagy
via phosphatidylinositol 3 kinase in human periodontal ligament cells
VL - 48
ID - 13340
ER -
TY - JOUR
AB - Background: Various clinical studies have demonstrated that applying
commercially available enamel matrix proteins (EMP) on the instrumented root
surface during access flap surgery promotes clinically significant gains of
clinical attachment and bone in intrabony defects. The aim of the present
controlled clinical trial was to evaluate the adjunctive effect of filling the
intrabony lesion with bovine porous bone mineral (BPBM) to a simplified papilla
preservation (SPP) flap and EMP surgical procedure. Methods: Sixty deep
interproximal intrabony lesions in 60 patients with chronic periodontitis were
treated with the SPP flap and EMP. In the 30 test defects, the intrabony component
was filled with BPBM particles previously reconstituted with the EMP gel. A
stringent infection control program was adopted for 1 year. The clinical and
radiographical reevaluation was made 1 year after surgery. Results: Both techniques
resulted in clinically and statistically significant improvements between baseline
and 1 year, in terms of clinical attachment level (CAL) gain, probing depth (PD)
reduction, and radiographic bone fill; however, the BPBM test treatment showed
statistically significantly greater CAL (5.8 ± 1.1 versus 4.9 ± 1.0) and
radiographic bone (DEPTH) level gains (5.3 ± 1.1 versus 4.3 ± 1.5), and less
increase in gingival recession (0.4 ± 0.6 versus 0.9 ± 0.5) than the control
surgical procedure. Conclusion: The present study data supported the hypothesis
that the adjunctive use of BPBM in grafting intrabony defects has the ability to
improve clinical and radiographical outcomes achievable with EMP alone.
AN - rayyan-563560874
AU - Zucchelli, G.
AU - Amore, C.
AU - Montebugnoli, L.
AU - De Sanctis, M.
DO - 10.1902/jop.2003.74.12.1725
IS - 12
chlorhexidine
enamel protein
adult
article
bovine
chronic disease
clinical trial
comparative study
controlled study
dental surgery
female
gingiva disease
human
human tissue
hypothesis
infection control
male
mouth hygiene
nonhuman
outcomes research
periodontitis
porosity
tooth papilla
tooth plaque
tooth radiography
tooth root canal
BioOss
Emdogain
LA - English
PY - 2003
SN - 0022-3492
SP - 1725-1735
ST - Enamel matrix proteins and bovine porous bone mineral in the treatment of
intrabony defects: A comparative controlled clinical trial
TI - Enamel matrix proteins and bovine porous bone mineral in the treatment of
intrabony defects: A comparative controlled clinical trial
VL - 74
ID - 14248
ER -
TY - JOUR
AB - Background: Bacterial contamination of membrane material negatively affects
healing after guided tissue regeneration (GTR) procedures; conversely, flap
connective tissue integration on barrier material improves the clinical outcomes.
The objective of this study was to evaluate the effect of topical application of
antibiotics on: 1) clinical outcomes of GTR surgical procedures using titanium
reinforced expanded polytetrafluoroethylene (ePTFE) periodontal membrane; 2)
bacterial colonization of membrane material; and 3) flap connective tissue-membrane
integration. Methods: Fifty-six deep interproximal bony defects were treated with
GTR surgical procedures using titanium reinforced ePTFE periodontal membranes.
Patients were randomly assigned to 1 of the 2 antimicrobial treatment groups: the
test group received weekly topical application of 25% metronidazole gel and the
control group received systemic antibiotics (amoxicillin plus clavulanic acid
1g/day for 14 days). Clinical outcomes were assessed at 1 year; the amount of
bacterial contamination and connective tissue integration on membrane material was
evaluated at time of membrane removal by means of a morphological (SEM) method.
Results: No statistically significant difference was found between test and control
groups in terms of clinical attachment (CAL) gain (baseline CAL - 12 months CAL; P
= 0.2) and probing depth (PD) reduction (baseline PD - 12 months PD; P = 0.6). A
greater increase in gingival recession (REC) (12 months REC - baseline REC) was
found in the test group compared to the control group (P = 0.003). The SEM analysis
revealed no statistically significant (t test) difference between test and control
groups in the number of fields positive to integrated connective tissue (P = 0.82),
while the number of fields positive to bacteria was statistically higher (P <
0.001) in the control group. Conclusions: Local antibiotic administration is more
effective than systemic use in preventing membrane contamination, but it does not
improve clinical outcomes due to an interference of the vehicle (gel) with gingival
tissues which may reduce the potential benefits derived from better control of the
bacterial load.
AN - rayyan-563561012
AU - Zucchelli, G.
AU - Sforza, N. M.
AU - Clauser, C.
AU - Cesari, C.
AU - De Sanctis, M.
DO - 10.1902/jop.1999.70.3.239
IS - 3
metronidazole
adult
aged
article
artificial membrane
bacterial metabolism
drug effect
female
human
infection control
male
mouth hygiene
outcomes research
tissue regeneration
wound healing
wound infection
LA - English
PY - 1999
SN - 0022-3492
SP - 239-247
ST - Topical and systemic antimicrobial therapy in guided tissue regeneration
TI - Topical and systemic antimicrobial therapy in guided tissue regeneration
VL - 70
ID - 14386
ER -
TY - JOUR
AB - Infection of the periodontal pocket presents two major challenges for drug
delivery: administration into the periodontal pocket and a high fluid clearance
rate in the pocket. The current study aimed to develop and study a novel hydrogel
system for delivery of the antibiotic drug metronidazole directly into the
periodontal pocket via injection followed by in situ gelation. The natural polymers
gelatin and alginate served as basic materials, and their crosslinking using a
carbodiimide resulted in a dual hydrogel network. The study focused on the effects
of the hydrogel’s formulation parameters on the drug release profile and the
hydrogel’s physical and mechanical properties. A cell viability test was conducted
on human fibroblasts. The metronidazole-loaded hydrogels demonstrated a decreasing
release rate with time, where most of the drug eluted within 24 h. These hydrogels
exhibited fibroblast viability of at least 75% after 24 and 48 h, indicating that
they are highly biocompatible. Although the alginate concentration used in this
study was relatively low, it had a strong effect on the physical as well as the
mechanical properties of the hydrogel. An increase in the alginate concentration
increased the crosslinking rate and enabled enhanced entanglement of the 3D
structure, resulting in a decrease in the gelation time (less than 10 s) and
swelling degree, which are both desired for the studied periodontal application.
Increasing the gelatin concentration without changing the crosslinker concentration
resulted in significant changes in the physical properties and slight changes in
the mechanical properties. Metronidazole incorporation slightly decreased the
hydrophilicity of the hydrogel and therefore also its viscosity, and affected the
sealing ability and the tensile and compression moduli. The developed hydrogels
exhibited controllable mechanical and physical properties, can target a wide range
of conditions, and are therefore of high significance in the field of periodontal
treatment.
AN - rayyan-563559824
AU - Zussman, M.
AU - Zilberman, M.
DO - 10.1177/08853282221079458
IS - 1
KW - alginic acid
gelatin
hydrogel
metronidazole
aqueous solution
article
cell viability
cytotoxicity
drug formulation
drug release
gelation
gelation time
human
human cell
hydrophilicity
in vitro study
newborn
room temperature
viscosity
LA - English
PY - 2022
SN - ["1530-8022", "0885-3282"]
SP - 166-179
ST - Injectable metronidazole-eluting gelatin-alginate hydrogels for local
TI - Injectable metronidazole-eluting gelatin-alginate hydrogels for local
VL - 37
ID - 13198
ER -

Exportlist

Uploaded by

Document Information

Original Description:

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Exportlist

Uploaded by

Copyright:

Available Formats

TY - JOUR

You might also like