Burn Dressings

19-12-05

Zohaib Hussain

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 Burn Wounds

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Trends in biotechnology, 36(9), 907-922.
Ideal Burn Wound Dressing

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Dressing based upon Wound Depth
and Exudates

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Types of Polymeric Dressings

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 Natural Polymers

a. sodium alginate b. Chitosan c. Dextran d. N-O-carboxymethyl chitosan

e. Hydroxyethyl starch f. Glucan g. Hyaluronic acid h. Poly-N-acetylglucosamine
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i. Silk j. Gelatin
Synthetic Polymers

a. polyvinyl alcohol
b. poly (N-isopropylacrylamide)
c. poly (N-vinylpyrrolidone)
d. polyethylene glycol
e. polyurethane)

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 Hydrocolloid Dressings
• The gel forming agents are combined with elastomers and adhesives
and applied to a carrier

• A variety of constituents including gelatin, pectin and sodium

carboxymethylcellulose in an adhesive polymer matrix.

• Forms a gel when their inner layer comes into contact with exudate

• Examples of a hydrocolloid dressing include Comfeel (Coloplast) and

DuoDerm (ConvaTec).

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SMARTPORE Technology®

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Comfeel® Plus
It consists of a semipermeable polyurethane film coated with a
flexible, cross-linked adhesive mass containing sodium
carboxymethylcellulose and calcium alginate

DuoDERM® Dressings
First to incorporate hydrocolloid technology
BETAplast®
It consists of polyurethane foam dressing impregnated with 3%
PVP-I, which has powerful antimicrobial properties
Medifoam®
A korea leading company in biomaterials especially wound
dressings 10
BETAplast®

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Commercial Products

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 Polyurethane Films Based Dressings

• Polyurethane films are transparent, adhesive-coated sheets

• Permeable to water vapour, oxygen and carbon dioxide but

not to liquid water or bacteria.

• Film dressings are suitable for lightly exuding wounds

• OpSite (Smith & Nephew) or Tegaderm(3M Company),

Finesse PU Film,
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 Polyurethanes
• Composed of urethane linkages in their main chains.
• Properties can be tuned-chemical structure, the molecular
weight of polyol, contents of hard and soft segment, or a
synthetic method.
• Fibers, elastomers, adhesives, coatings, synthetic leathers and
construction materials.
• Hydrophilic (PEG)

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 Hydrogel Dressings
• High water content gels containing insoluble polymers d by crosslinking of
polymers (PVA, PEO)
• Modified carboxymethylcellulose, hemicellulose, agar, glycerol and pectin.

• More capacity to absorb fluid-higher levels of wound exudate-Autolytic

debridement

• Amorphous form (a loose gel)

• such as IntraSite (Smith & Nephew) and Solugel,

• Sheet form where the gel is presented with a fixed three-dimensional macro
structure.
• Aqua clear and Nu-gel (Johnson & Johnson) 15
INTRASITE Gel
• Amorphous hydrogel-contains propylene glycol

• SOLUGEL™
Wound Care Gel is a clear hydrogel
• Purilon® gel
Consists of purified water, sodium carboxymethylcellulose, and
calcium alginate. Natural ingredients-No additives

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Commercial Products

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 Alginate Dressings
• Calcium or sodium/calcium salts of alginate acid-seaweed

• Sodium salts present in the wound exchange with the calcium in the alginate
to form sodium alginate, a hydrophilic gel

• Ability to absorb exudate into itself while maintaining a moist environment.

• Highly absorbent, form gel with exudates, provide a moist interface, are
easily removed-Rinsed away with saline irrigation

• (Algisite M™, Sorbsan™, Algosteril (Johnson & Johnson), Comfeel Alginate

Dressing (Coloplast), Carrasorb H (Carrington Laboratories), Kaltostat
(ConvaTec), quacel®, Aquacel Extra® and Aquacel Foam®.
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Commercial Products

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 Silk Fibroin
• Poor mechanical strength of collagen that restricts its applications
for wound dressings
• SF is a flexible polymer with excellent mechanical properties,
including tensile strength (0.5 GPa), breaking elongation (15%), and
elasticity (<35%)
• Cross-linked structure of elastin hinders its processability and
decreases its solubility. Additionally, available supplies of elastin are
more limited
• SF has high solubility in aqueous salt solutions
• nanofibers, sponges, films, and hydrogels.
• Synthetic polymers, such as soft silicon are not biodegradable,
Polyurethanes-toxicity of the degradation products
• SF is categorized as a non-degradable material based on the US
Pharmacopeia’s definition 20
 Silk Fibroin

Chouhan, D., Lohe, T. U., Samudrala, P. K., & Mandal, B. B. (2018). In situ forming injectable silk
fibroin hydrogel promotes skin regeneration in full thickness burn wounds. Advanced healthcare21
materials, 7(24), 1801092.
 Foam Dressings
• Soft, open-celled hydrophobic/hydrophilic non-adherent dressings that may
be single or multiple layered and meet many of the properties of an ideal
dressing
• Exudry™ Zetuvit™ and Mesorb® are examples of products with a highly
absorbent pad and a non-stick, non-shear surface.

• As a secondary dressing over moderate to highly exudating wounds and over

hydrocolloid paste, cadexomer iodine, alginate and other primary dressings.

• Zetuvit E is a non-irritant absorbent dressing pad. The covering layer consists

of hydrophobic, non-woven polypropelene material.

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 Nanofiber-based Wound Dressings
An electrospun-nanofibrous layer is applied to a basic support
fabric material

• Haemostasis

• High filtration & liquid absorption efficiency

• Semi-permeability: Facilitate cell respiration due to their porosity

• Conformability

• Functional ability

• Scar free
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Commercial Products

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 Hydroactive Dressings
• Hydroactive dressings are multi-layered highly absorbent polymer
dressings with a surface adhesive and a waterproof outer layer are
similar to hydrocolloids, however, instead of forming a gel in
contact with exudate, the fluid is trapped within the product itself,
to maintain a moist environment.
• highly absorbent polymer dressings
• waterproof
• non-residual
• semi-permeable

Cutinova Hydro™, Tielle™, Biatain™Cavity dressing, PolyMem® 25

 Conclusion

A wound dressing thus approaching ideal characteristics should

conform to the site of the wound, offer alleviation of pain
symptoms, promote faster wound-healing time and attempt to
restore the patients’ normal daily activities
The need for a more holistic approach towards wound healing and
management so that while selecting the appropriate dressing for a
wound, the physiological and biochemical requirement of the
wound and the patient are also taken into account.
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