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Grand Rounds Case Presentation
Grand Rounds Case Presentation
Grand Rounds Case Presentation
GENERAL OBJECTIVE
To present a case of S.O.Y., a 16-year-old male who came in for syncope.
SPECIFIC OBJECTIVE
To present the history and clinical manifestations of the patient
To discuss the etiology and pathophysiology of Anaphylaxis
To discuss the diagnosis, treatment, complications and prognosis of Anaphylaxis
CASE PROTOCOL: This is a case of SOY, a 16-year-old male, Filipino, born on December 26, 2006,
Roman Catholic, from Basey, Western Samar, was admitted for the first time last July 27, 2023
due to syncope and urticaria.
Sixteen hours prior to admission, patient noted difficulty of breathing associated with
chest pain described as heaviness, nonradiating while lying on bed, body weakness and
syncope, two episodes, described as complete loss of consciousness of approximately less than
one minute preceded by blurring and tunnelling of vision with spontaneous recovery. No noted
dyspnea, abdominal pain, vomiting, incontinence, oral trauma, confusion nor myalgias. Patient
was rushed to a public district hospital. An elevated blood pressure was noted at 160/100mmHg
thus was given Carvedilol 25 mg/tab, one tab sat dose and pruritic skin rashes located at the
face and chest given Diphenhydramine 50 mg IV, stat dose. Laboratories were done included
complete blood count which showed hemoglobin of 163 g/L, hematrocrit of 0.50 l/l,
neutrophilia at 81% and decreased lymphocytes of 15% with platelet count of 329 l/I, blood
chemistry as follows blood uric acid at 530 umol/L, creatinine 90.4 umol/L, BUN 3.60 mmol/L,
SGPT 34.4 U/L and SGOT 22.7 U/L. The serum electrolytes requested showed results of
decreased potassium of 3.3 mmol/L, sodium 137 mmol/L and ionized calcium of 109 mmol/L.
Urinalysis had normal results. Diagnostics such as 12 lead ECG and Chest xray APL were normal.
Twelve hours prior to admission, patient was referred to a private hospital and was
admitted for persistent hypertension and pruritic skin rashes associated with abdominal pain,
blurring of vision and difficulty of breathing. Started on Hydrocortisone 100mg IVTT every 12
hours, Diphenhydramine 25mg IVTT every 12 hours, Omeprazole 40mg IVTT every 24 hours, and
Salbutamol nebulization, one nebule every 6 hours and Carvedilol 25 mg/tab, one tablet once
daily was continued.
Two hours prior to admission, while admitted at the private hospital, patient
experienced chest tightness associated with difficulty of breathing and body weakness followed
by a syncopal attack while at the bathroom, described as complete loss of consciousness of
approximately less than one minute also preceded by blurring and tunnelling of vision with
spontaneous recovery. There was slurring of speech noted. Still no incontinence, oral trauma,
confusion nor myalgias. The patient had elevated blood pressure at 170/70mmHg and fever
with Tmax of 38.3C, tachycardic at 99bpm and tachypneic at 23cpm. Upon physical examination,
there was persistence of facial and chest erythematous rashes and decreased muscle strength
of both upper and lower extremities. Given Clonidine 75mg/ tab, one tablet sublingual as stat
dose and Paracetamol 300mg IVTT. Patient was referred to our institution for close monitoring
at the intensive care unit.
REVIEW OF SYSTEMS
He was born full term, with good cry and activity to a then 27 year old, G3P3 (3003)
nonalcoholic, nonhypertensive mother, via Normal Spontaneous Delivery at home assisted by
traditional birth attendant. The mother had no exposure to teratogenic substances but had
Urinary Tract Infection on the second trimester of pregnancy but no medications were given.
GROSS MOTOR
8 months- sat without support
10 months- stood alone
15 months- walked alone without support
2 years- ran well
3 years- climbed well
4 years- caught a bounced ball
LANGUAGE
12 months- followed 1 step command
2 years- pointed body parts, 3 words sentences
3 years- said first name
4 years- said first and last name
FINE MOTOR
2 years- imitated vertical line
3 years- turned book page
4 years- copied some letter
IMMUNIZATION
BCG and Hepatitis B vaccine given at birth; Pentavalent vaccine (DPT-HepaB-HIB), OPV and
Pneumococcal Conjugate Vaccine (PCV) given starting at 1.5 months for 3 doses, one month
apart; Inactivated Polio Vaccine (IPV) given at 3.5 months and Measles, Mumps and Rubella
(MMR) vaccine given at 1 year old. Covid-19 vaccine (Pfizer) given for 2 doses. No booster doses
given. No annual influenza vaccine received.
Patient is a known allergies to foods since childhood with no maintenance medications, last
attack was last 2009 and was given short acting Beta agonist with relief of symptoms. There was
a previous admission for 3 days at a local government hospital last 2022 for difficulty of
breathing and transient loss of consiousness in which he was discharged improved. Patient has
known allergy to foods like chicken, eggs and canned goods. Additionally, was diagnosed with
Cold Urticaria by a private dermatologist (about a week prior to admission). Given Fexofenadine
Hydrochloride 120mg/tab, once daily, Lobetasol propionate 0.05% cream to affected areas and
Vitamin C Supplementation.
Patient is the third among siblings. His 43-year-old hypertensive mother, 49-year-old
hypertensive father, and five siblings were all apparently well. On the maternal side, a history of
recurrent Anaphylaxis was noted on the Aunt with emergency Epinephrine pen use and
Bronchial Asthma. A history of Diabetes Mellitus is noted on the paternal side of the family.
Both parents have a family history of Hypertension. No other heredofamilial diseases noted. No
history of sudden cardiac death nor malignancy in the family.
FAMILY GENOGRAM
SOCIOECONOMIC AND ENVIRONMENTAL HISTORY
Both parents manage a family-owned business. The patient is the third of six siblings. He lives in
a two-storey fully concrete house with good ventilation and electricity source, which is shared
with nine household members. There are no sick family members noted. The source of drinking
water is mineralized bought from a refilling station. The garbage is collected three times weekly.
The family owns cats as pets. No noted exposure to cigarette smoking.
HEADDS
HOME
Patient lives with parents and five other siblings. He has his own room in a concrete 2-storey
family-owned house. He has a good relationship and open communication with all family
members.
EDUCATION
He is a Grade 11 honor student and athlete in Liceo del Verbo Divino, Tacloban City. Patient goes
to the same school with two other siblings. He denies experiencing bullying in school. Patient
felt safe in school.
EATING HABITS
Patient is not a picky eater with good appetite, however, he has reported allergies to foods such
as chicken, eggs, some fish types and canned goods. He is not concerned about his weight nor
body changes.
ACTIVITIES
Patient plays volleyball and enjoys playing mobile games. He spends an ample time in different
social media platforms.
DRUGS/ ALCOHOL
Patient denies illicit drug use. He is a nonsmoker and non-alcoholic beverage drinker.
SEXUALITY
He is attracted to both sexes, male and female, but denies engaging in sexual activities.
SUICIDALITY
Patient had suicidal ideation during the pandemic. He felt depressed but denies hurting himself.
He negates any major family problems.
SAFETY
He feels safe at home and in the neighborhood. Patient denies any experience of abuse. He has
not encountered any major accidents.
PHYSICAL EXAMINATION:
General Survey: The patient was drowsy with speech difficulty, coherent, oriented to time, place
and person, well-nourished, well-developed, in cardiorespiratory distress
Vital Signs
BP: 135/52 mmHg HR: 90bpm RR: 27cpm Temp: 37.9C CRT <2 seconds
O2 sat: 100% on O2 support at 5LPM via nasal cannula
HEENT:
Symmetrical facial features with urticarial rashes (blanchable, eythematous, raised rashes, some
linear and annular) sparing periorbital and perioral areas; no palpable head mass, hair normal
texture and equally distributed; anicteric sclerae, pink palpebral conjunctiva, eyes not sunken;
symmetrical, midline nose with nasal discharge, angioedema of lips and tongue; tonsils not
assessed; no cervical lymphadenopathy
CARDIOVASCULAR SYSTEM:
Adynamic precordium, tachycardic, regular rhythm, distinct S1 and S2, no murmur
ABDOMEN:
Flabby, with urticarial rashes noted, normoactive bowel sounds, soft, nontender, tympanitic all
over
EXTREMITIES:
Grossly normal extremities with urticarial rashes, no edema, no clubbing, full and equal pulses
Stage IV- increased size of penis, nonedematous, with growth in breadth and development of
glans; testes and scrotum larger, scrotal skin darker
NEUROLOGIC EXAMINATION
GLASCOW COMA SCALE 15
MENTAL STATUS
drowsy, coherent, oriented to time, place and person
CRANIAL NERVES
CN I- no anosmia
CN II, III- pupils equal, reactive to light and accomodation with good peripheral vision
CN III, IV, VI- no nystagmus, intact EOM
CN V, VII- (+) corneal reflex
CN VII-no facial asymmetry
CN VIII-no hearing loss; responsive to verbal stimuli
CN IX, X- intact gag reflex
CN XI-able to turn head and shrug shoulder against resistance
CN XII-tongue at midline, no fasciculations
Motor- No atrophy; decreased muscle strength at 3/5- active movement against gravity in all
extremities and weak functional grip
Sensory- Intact sensory function of both lower and upper extremities to light touch and
pressure, withdraws from painful stimulus equally
Cerebellar-no dysdiadokinesia, well-coordinated movements
Meningeal- no nuchal rigidity, negative Kernig’s sign, negative Brudzinki’s sign
Pathologic-negative Babinski, negative Chaddok
ADMITTING IMPRESSION:
HYPERTENSIVE EMERGENCY; to consider STROKE IN THE YOUNG;
HYPERTENSITIVITY DISORDER probably secondary to FOOD INTAKE
CBC PC Hgb Hct RBC WBC Neutrophils Lymphocytes Monocytes Eosinophil Basophil Platelet
count
7/27/23 160 0.47 5.84 7.93 0.82 0.10 0.08 0.00 0.00 308
O- Vital signs were as follows: Blood pressure of 126/58mmHg, heart rate at 93bpm, respiratory
rate of 13 cpm, afebrile at 37.5C with 98% O2 saturation at 2LPM O2 support. Skin was flushed,
with urticarial lesions and angioedema of lips and eyelids. Patient had clear breath sounds on
auscultation. No stridor nor wheeze noted. The Glascow Coma Score remained at 15. Patient
was conscious, coherent, conversant and follows command. Intact short- and long-term
memory. No preferrential gaze. No facial asymmetry, tongue at midline and responsive to verbal
stimuli. Motor strength at score of 2/5, active movement only when gravity is eliminated.
6 hours after recurrence of anaphylaxis symptoms, patient was conscious, coherent and
conversant. Still with occasional cough, nonproductive. No syncope, no abdominal pain, no
nausea, no vomiting, no slurring of speech, no chest pain, no difficulty of breathing, no fever, no
headache nor dizziness. Vital signs were stable at blood pressure of 119/57mmHg, heart rate of
77 cpm, respiratory rate of 18 cpm and 98% O2 saturation on 2LPM oxygen via nasal cannula.
Skin was not flushed. No urticarial lesions nor angioedema noted but dermatographism after
skin stroking was elicited. There were crackles upon lung auscultation. No wheezes nor
retractions. Patient had warm extremities, full equal pulses and motor strength at score of 4/5,
active movement against gravity. Oxygen support was then discontinued without episodes of
desaturation.
CBC PC Hgb Hct RBC WBC Neutrophils Lymphocytes Monocytes Eosinophil Basophil Platelet
count
7/27/23 160 0.47 5.84 7.93 0.82 0.10 0.08 0.00 0.00 308
7/28/23 145 0.43 5.23 7.21 0.77 0.15 0.08 0.00 0.00 223
T3 T4 TSH
Normal 0.92- 66-181 0.27-
values 2.33 4.20
7/27/23 122.03 1.27
nmol/L uIU/ml
7/28/23 1.2
nmol/L
FOOD DIARY Breakfast Lunch Dinner
Date
7/28/23 “Lugaw” (porridge) “Lugaw” (porridge), Rice and burger steak
and ground meat soup
O- Vital signs were as follows blood pressure of 118/66mmHg, heart rate of 61bpm, respiratory
rate at 15cpm, temperature of T36 oC with oxygen saturation of 98% at room air. Skin was not
flushed. There was absence of urticarial lesions. Lips and eyelids were not swollen. The chest
had symmetrical chest expansion with decreased crackles at the left lung fields, no wheezes nor
retractions. Abdomen was flat, soft and nontender. The extremities were grossly normal.
Regained motor strength at 5/5. Glascow coma score of 15. Patient was oriented, cooperative,
conversant and speaks dialect fluently.
Q-
F: Heplock
R: Noted decreased cough, nonproductive; no DOB
Symmetrical chest expansion, decreased crackles, left lung fields, no wheeze, no
retractions
98% O2 saturation at room air
I: No febrile episodes
Cefuroxime 4.5gm/day (Day 3)
C: Normal rate, regular rhythm
Captopril to 50mg/day
H: No bleeding
M: No electrolyte imbalance
O: Positive fluid balance I: 1,460 O: 920
UO 1.0 cc/kg/hr
N: GCS 15
Tongue midline, No facial asymmetry
D: Low salt, low fat diet with avoidance of known allergens
Daily food diary
For Kato Katz as OPD
Home Medications:
1. Ebastine + Betamethasone 10mg/ 100mcg tab (Co-Aleva), 1 tab for 3 days
more
2. Captopril 25mg/tab, 1 tablet BID
3. Cefuroxime 500mg/tab (Cimex), 1 tablet every 12hours for 5 more days
4. N-Acetylcysteine 600mg/tab, 1 tab ODHS for 3 days
5. Bilastine 20mg/tab (Bilaxten) OD for 1 month
6. Epinephrine 0.3 mg IM as emergency medication for recurrence of
anaphylaxis
Final Diagnosis: