Revision: Amino Acids, Proteins

1. Proteins are polymers of ______

a) α-amino acids
b) β-amino acids
c) γ-amino acids
d) δ-amino acids

2. Amino acids behave like carboxylic acids

a) True
b) False

3. Amino acids can show amphoteric behaviour.

a) True
b) False

4. Which of the following amino acids are aromatic in nature?

a) Methionine
b) Isoleucine
c) Proline
d) Histidine

5. Which of the following is a non-essential amino acid?

a) Threonine
b) Glutamine
c) Phenylalanine
d) Valine

6. Which of the following is a neutral amino acid?

a) Glycine
b) Lysine
c) Arginine
d) Histidine

7. Cysteine is a/an ________ amino acid.

a) acidic
b) essential
c) aromatic
d) sulphur containing

8. Which of the following amino acids contains only one amino group?
a) Leucine
b) Lysine
c) Asparagine
d) Glutamine

9. Which part of the amino acid gives it uniqueness?

a) Amino group
b) Carboxyl group
c) Side chain
d) None of the mentioned
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10. What is the one letter code for asparagine?
a) A
b) P
c) N
d) S

11. Which of the following is incorrect regarding tryptophan?

a) It is an essential amino acid
b) It is a basic amino acid
c) It has an aromatic side chain
d) It is a non-polar amino acid

12. The structure shown below is ______

a) Side chain of histidine

b) Side chain of tryptophan
c) Side chain of proline
d) Proline

13. Identify the amino acid with the formula HOOC-CH2-CH2-CH(NH2)-COOH.

a) Glutamic acid
b) Aspartic acid
c) Glutamine
d) Asparagine

14. Proteins are _______

a) dipeptides
b) tripeptides
c) tetrapeptides
d) polypeptides

15. Alanylglycyl phenylalanine is an example of a ______

a) dipeptide
b) tripeptide
c) tetrapeptide
d) polypeptide

16. Which of the following bonds in not found in fibrous proteins?

a) Phosphodiester
b) Peptide
c) Hydrogen bonds
d) Disulphide

17. Which of the following is not a fibrous protein?

a) Keratin
b) Myosin
c) Collagen
d) Albumin
18. The sequence in which amino acids are arranged in a protein is called ______ structure.
a) primary
b) secondary
c) fibrous
d) sheet

19. Which of the following is soluble in water?

a) Insulin
b) Elastin
c) Fibroin
d) Collagen

20. Fibrous and globular proteins are classified on the basis of ______ structure.
a) primary
b) secondary
c) tertiary
d) quaternary

21. A protein ‘X’ was found in a biological system with a unique 3-D structure and biological
activity. ‘X’ is known as _______
a) tertiary structure
b) quaternary structure
c) native protein
d) globular protein

22. The primary structure of protein is unaffected by denaturation.

a) True
b) False

23. Boiling an egg is an example of reversible denaturation.

a) True
b) False

24. During the formation of the peptide bond which of the following takes place?
a) Hydroxyl group is lost from its carboxyl group of one amino acid and a hydrogen atom is lost
from its amino group of another amino acid
b) Hydrogen atom is lost from its carboxyl group of one amino acid and a hydroxyl group is lost
from its amino group of another amino acid
c) Hydroxyl group is lost from its carboxyl group of one amino acid and a hydroxyl group is lost
from its amino group of another amino acid
d) Hydrogen atom is lost from its carboxyl group of one amino acid and a hydrogen atom is lost
from its amino group of another amino acid

25. A tripeptide has _________

a) 3 amino acids and 1 peptide bond
b) 3 amino acids and 2 peptide bonds
c) 3 amino acids and 3 peptide bonds
d) 3 amino acids and 4 peptide bonds

26. The factor which does not affect pKa value of an amino acid is _

a) The loss of charge in the α-carboxyl and α-amino groups

b) The interactions with other peptide R groups
c) Other environmental factors
d) Molecular weight

27. Which of the following information is responsible to specify the three-dimensional shape
of a protein?
a) The protein’s peptide bond
b) The protein’s amino acid sequence
c) The protein’s interaction with other polypeptides
d) The protein’s interaction with molecular chaperons

28. Unfolding of a protein can be termed as _________

a) Renaturation
b) Denaturation
c) Oxidation
d) Reduction

29. What are the following is not a factor responsible for the denaturation of proteins?
a) pH change
b) Organic solvents
c) Heat
d) Charge

30. Which of the following statements are true?

a) Primary structure of a protein determines how it folds up into a unique three dimensional
structure
b) Secondary structure of a protein determines how it folds up into a unique three dimensional
structure
c) Three dimensional structure of a protein determines the function of a protein
d) Amino acid sequence is absolutely invariant for a particular protein

31. Which of the following are true?

a) The two main types of secondary structure are the α helix and β pleet structures
b) α helix is a right handed coiled strand
c) The hydrogen bonding in a β-sheet is between strands rather than within strands
d) The hydrogen bonding in a β-sheet is within strands rather than between strands

32. Native state of a protein can be disrupted by __________

a) Temperature
b) pH
c) Removal of water
d) Presence of hydrophilic surfaces

33. Which of the following is true?

a) The disulfide bridges formed by reduction of the sulfhydryl groups on cysteine stabilizes
protein tertiary structure
b) The disulfide bridges formed by oxidation of the sulfhydryl groups on cysteine destabilizes
protein tertiary structure
c) The disulfide bridges formed by oxidation of the sulfhydryl groups on cysteine stabilizes
protein tertiary structure
d) The disulfide bridges formed by reduction of the sulfhydryl groups on cysteine destabilizes
protein tertiary structure