Common Vaccines and the Risk of Incident Dementia: A Population-... https://pubmed.ncbi.nlm.nih.

gov/36542511/

Common Vaccines and the Risk of Incident Dementia: A Population-based

Cohort Study - PubMed

Zharmaine Ante 2 ,

. 2023 May 29;227(11):1227-1236.

doi: 10.1093/infdis/jiac484.

Affiliations

PMID: 36542511

DOI: 10.1093/infdis/jiac484

Common Vaccines and the Risk of Incident Dementia: A Population-based Cohort Study

Antonios Douros et al. J Infect Dis. 2023.

Abstract

Background: Observational studies suggesting that immunizations strongly decrease the risk of dementia had several methodological
limitations. We assessed whether common vaccines are associated with the risk of dementia.

Methods: We assembled a population-based cohort of dementia-free individuals aged ≥50 years in the United Kingdom's Clinical Practice
Research Datalink between 1988 and 2018. Using a nested case-control approach, we matched each patient with dementia with 4 controls.
Conditional logistic regression yielded confounder-adjusted odds ratios (ORs) with 95% confidence intervals (CIs) of dementia associated
with common vaccines >2 years before the index date compared with no exposure during the study period. Moreover, we applied a 10-year
lag period and used active comparators (participation in breast or prostate cancer screening) to account for detection bias.

Results: Common vaccines were associated with an increased risk of dementia (OR, 1.38 [95% CI, 1.36-1.40]), compared with no exposure.
Applying a 10-year lag period (OR, 1.20 [95% CI, 1.18-1.23]) and comparing versus prostate cancer screening (1.19 [ 1.11-1.27]) but not breast
cancer screening (1.37 [1.30-1.45]) attenuated the risk increase.

Conclusions: Common vaccines were not associated with a decreased risk of dementia. Unmeasured confounding and detection bias likely
accounted for the observed increased risk.

Keywords: epidemiology; immunization; public health; real-world evidence.

© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For
permissions, please e-mail: journals.permissions@oup.com.

Conflict of interest statement

Potential conflicts of interest . S. S. attended scientific advisory committee meetings or consulted for AstraZeneca, Atara, Bristol-Myers-
Squibb, Merck, Novartis, Panalgo, Pfizer, and Seqirus and received speaking fees from Boehringer-Ingelheim and Novartis. P. B. received
consulting fees from Becton Dickinson on topics unrelated to the current work. All other authors report no potential conflicts. All authors
have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of
the manuscript have been disclosed.

Comment in

Commentary on "Common Vaccines and the Risk of Dementia: A Population-Based Cohort Study": Science Can be Messy but Eventually
Leads to Truths.

Salmon DA, Black S, Didierlaurent AM, Moulton LH. Salmon DA, et al. J Infect Dis. 2023 May 29;227(11):1224-1226. doi: 10.1093/infdis
/jiac487. J Infect Dis. 2023. PMID: 36542509 No abstract available.

Similar articles

Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.

Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K,
Green P. Crider K, et al. Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217. Cochrane Database
Syst Rev. 2022. PMID: 36321557 Free PMC article.

1 de 2 11/06/2023, 18:51
Common Vaccines and the Risk of Incident Dementia: A Population-... https://pubmed.ncbi.nlm.nih.gov/36542511/

Baseline Prostate-specific Antigen Level in Midlife and Aggressive Prostate Cancer in Black Men.

Preston MA, Gerke T, Carlsson SV, Signorello L, Sjoberg DD, Markt SC, Kibel AS, Trinh QD, Steinwandel M, Blot W, Vickers AJ, Lilja H,
Mucci LA, Wilson KM. Preston MA, et al. Eur Urol. 2019 Mar;75(3):399-407. doi: 10.1016/j.eururo.2018.08.032. Epub 2018 Sep 17. Eur
Urol. 2019. PMID: 30237027 Free PMC article.

Androgen Deprivation Therapy and the Risk of Dementia in Patients With Prostate Cancer.

Khosrow-Khavar F, Rej S, Yin H, Aprikian A, Azoulay L. Khosrow-Khavar F, et al. J Clin Oncol. 2017 Jan 10;35(2):201-207. doi:
10.1200/JCO.2016.69.6203. Epub 2016 Nov 21. J Clin Oncol. 2017. PMID: 27870566

Selenium for preventing cancer.

Vinceti M, Filippini T, Del Giovane C, Dennert G, Zwahlen M, Brinkman M, Zeegers MP, Horneber M, D'Amico R, Crespi CM. Vinceti M, et
al. Cochrane Database Syst Rev. 2018 Jan 29;1(1):CD005195. doi: 10.1002/14651858.CD005195.pub4. Cochrane Database Syst Rev. 2018.
PMID: 29376219 Free PMC article. Review.

Digital Breast Tomosynthesis with Hologic 3D Mammography Selenia Dimensions System for Use in Breast Cancer Screening: A Single
Technology Assessment [Internet].

Movik E, Dalsbø TK, Fagelund BC, Friberg EG, Håheim LL, Skår Å. Movik E, et al. Oslo, Norway: Knowledge Centre for the Health Services
at The Norwegian Institute of Public Health (NIPH); 2017 Sep 4. Report from the Norwegian Institute of Public Health No. 2017-08. Oslo,
Norway: Knowledge Centre for the Health Services at The Norwegian Institute of Public Health (NIPH); 2017 Sep 4. Report from the
Norwegian Institute of Public Health No. 2017-08. PMID: 29553669 Free Books & Documents. Review.

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Ovid Technologies, Inc.

Silverchair Information Systems

Medical

MedlinePlus Health Information

2 de 2 11/06/2023, 18:51