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Extracellular fluid Plasma membrane Cytosol

K+ leak channel K+ leak channel


closed + open
K+ K

Channel randomly

opens and closes

(a) Leak channel

Ligand-gated Ca2+ Ligand-gated


channel closed Acetylcholine channel open
Na+

Chemical stimulus

opens the channel

K+

(b) Ligand-gated channel

Mechanically-gated channel Ca2+ Mechanically-


closed gated channel
open
Na+
Mechanical stimulus

opens the channel

(c) Mechanically-gated channel

Voltage-gated Voltage-gated
K+ channel K+ K+ channel open
K+
closed
Change in
membrane potential

opens the channel

Voltage = –70 mV Voltage = –50 mV

(d) Voltage-gated channel

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