Drug study Clozapine

Generic: Dosage: 25 mg Interferes with binding Schizophrenia Seizures (occasionally) Do not stop the 1. Assess behavior, appearance,
Clozapine of dopamine and Overdose produces medications abruptly emotional status, response to
serotonin receptor sites, CNS depression environment, speech pattern,
Route: Oral thereby diminishing (sedation, delirium, Use cautiously thought content.
schizophrenic coma), respiratory among smokers 2. Monitor BP for
Brand: Syclop Frequency: BID behavior. depression, hypertension/hypotension.
hypersalivation. Use cautiously 3. Assess pulse for tachycardia
Blood dyscrasias, among patients with (common side effect).
Timing: 8, 6 particularly CV or 4. Monitor CBC for blood
agranulocytosis, mild cerebrovascular dyscrasias.
leukopenia, may occur. disease or conditions 5. Supervise suicidal-risk pt
Classification Contraindications Side Effects predisposing to closely during early therapy
Functional: ● Hypersensitivity ● Blurred vision hypotension, history (as depression lessens,
Second- to clozapine. ● Dizziness of or risk factors for energy level improves,
generation ● History of ● Fast heartbeat seizure, risk or increasing suicide potential).
(atypical) clozapine- ● Shaking of the history of QT 6. Assess for therapeutic
antipsychotic induced hands or feet prolongation, DM, response (interest in
agranulocytosis ● Constipation BPH, urinary surroundings, improvement
or severe ● Increased salivation retention, xerostomia, in self- care, increased ability
granulocytope- ● Anxiety decreased to concentrate, relaxed facial
Chemical: nia. ● Dry mouth gastrointestinal expression)
C18H19ClN4 ● Weight gain motility, visual 7.
● Acid or sour problems.
stomach
● Muscle pain PATIENT/FAMILY
● Sore throat TEACHING
● Do not abruptly
 discontinue long-
term drug
therapy.
● Avoid tasks that
require alertness,
motor skills until
response to drug
is established.
● Drowsiness
generally
subsides during
continued
therapy.
● Avoid alcohol,
caffeine.
● Report fever, sore
throat, flu-like
symptoms.