Understanding T Cells:

Function, Structure,
Location, Related
Diseases and
Treatments

Espino Lopez Linda

Fernández Godínez Iván
Gutiérrez Cristóbal Efrén
Piña Mendieta Yutzil
 Introduction to T cells

T cells are a type of white blood

cell that play a fundamental
role in defending the body
against infections and diseases.
They are also called T
lymphocytes.
 T cell structure

T cells have several essential components that

allow them to function properly.

T cell receptor.
Costimulation molecules.
Adhesion molecules and cytokines.

All of these components work together to

activate T cells and carry out an effective
immune response.
T cell function

T cells are responsible for

coordinating the specific
immune response. They
recognize and eliminate
infected or cancerous cells.
Additionally, they help B cells
produce antibodies. T cells
also play an important role in
immunological memory,
allowing the body to
remember and respond
quickly to previous infections.
 Types of T cells

There are two main types of T cells:

1. CD4+ T cells.
2. CD8+ T cells.

CD4+ T cells help B cells make

antibodies and activate other immune
system cells. CD8+ T cells recognize
and eliminate infected or cancerous
cells directly.
 Localization of T cells

T cells are found in different parts of the body,

such as:
The blood
Thymus
Lymph nodes
Spleen.

They can also infiltrate diseased tissues, such

as:
Tumors.
Inflamed tissues.
The skin.
Intestine.

The localization of T cells is important to

understand how certain pathologies develop.
T cells are a key component of the immune
system that are essential for defense
against pathogens and abnormal cells.
Their structure and essential components
allow them to carry out an effective
immune response.
Diseases related
to T cells

Diseases related to T cells include:

T-cell acute lymphocytic

leukemia.
T cell lymphoma.
Graft versus host disease.

These diseases are characterized

by abnormal growth of T cells.
Treatments for T cell-related
diseases

Treatments for T cell-related

diseases include
chemotherapy, targeted
therapy, and stem cell
transplant. Immune
therapies are also being
developed to boost the
immune system and attack
anormal T cells.
CAR-T cell immunotherapy

CAR-T cell therapy is a form of

immunotherapy in which the
patient's T cells are genetically
modified so that they can
recognize and attack cancer
cells. This therapy has been
used successfully in the
treatment of certain types of
cancer, such as B-cell acute
lymphocytic leukemia.
 References
Miyara M, Sakaguchi S. Natural regulatory T cells: mechanisms of sup-pression.
Trends Mol Med. 2007;13(3):108-16.

Pandiyan P, Zheng L, Ishihara S, Reed J, Lenardo MJ.

CD4+CD25+Foxp3+regulatory T cells induce cytokine deprivation-
mediatedapoptosis ofeffector CD4+ T cells. Nat Immunol. 2007;8(12):1353-62.

Oberle N, Eberhardt N, Falk CS, Krammer PH, Suri-Payer E. Rapid sup-pression

of cytokine transcription in human CD4+CD25 T cells byCD4+Foxp3+ regulatory
T cells: independence of IL-2 consumption,TGF-beta, and various inhibitors ofT
CR signaling. J Immunol.2007;179(6):3578-87
¡Thank you!