© 2021 Christel Bergström

• Prodrugs (Jarkko Rautio)

• Nanoparticles (Alexandra Teleki)
• Liposomes (Gøril Eide Flaten)
• Mesoporous carriers (Caroline Alvebratt)

© 2021, Maria Karlgren, Department of Pharmacy, Uppsala University

© 2021, Maria Karlgren, Department of Pharmacy, Uppsala University
The right amount to the Drugs are not inherently
right location at the Drug effective - the benefit of a
right time Delivery drug is directly related to
the manner by which it is
administered or delivered

© 2021 Christel Bergström

Drug discovery: Drug development:
molecule focus medicine focus
So where did the
medicine come from??

Valley of death

© 2021 Christel Bergström

 Compliance New
/ patient- indication
friendly
Drug discovery: Drug development:
molecule focus medicine focus
Drug
Drug Delivery Delivery

New
patient Improved
population safety

Improved
effect (PK)

© 2021 Christel Bergström

Drug discovery: Drug development:
molecule focus medicine focus

© 2021 Christel Bergström

Stella VJ, J Pharm Sci, 2020 doi: 10.1016/j.xphs.2020.09.037
© 2021 Christel Bergström
Stella VJ, J Pharm Sci, 2020 doi: 10.1016/j.xphs.2020.09.037
© 2021 Christel Bergström
 Case study: ciprofloxacin
Tm of 266°C, low permeability,
lowest solubility at pH 7.4

Tehler et al., J Med Chem 2013. doi: 10.1021/jm301721e

© 2021 Christel Bergström
 Case study: ciprofloxacin
Tm of 266°C, low permeability,
lowest solubility at pH 7.4

Tehler et al., J Med Chem 2013. doi: 10.1021/jm301721e

© 2021 Christel Bergström
Hu et al., Angew Chem 2016. doi: 10.1002/anie.201604207 © 2021 Christel Bergström
© 2021 Christel Bergström
• encapsulation efficiency
• drug loading
• release mechanisms
• targeted delivery required? (i.e. need for decoration?)
• safety
• stability
• bioactivation/biodegradation
• are they GRAS or likely to be sorted as GRAS (generally regarded as safe)

© 2021 Christel Bergström

© 2021 Christel Bergström
Chen et al., Eur J Pharm Biopharm, 2021. doi: 10.1016/j.ejpb.2021.04.025 © 2021 Christel Bergström
Chen et al., Eur J Pharm Biopharm, 2021. doi: 10.1016/j.ejpb.2021.04.025 © 2021 Christel Bergström
Chen et al., Eur J Pharm Biopharm, 2021. doi: 10.1016/j.ejpb.2021.04.025 © 2021 Christel Bergström
 ‘The pharmaceutical drug delivery technology market is projected to
reach USD 2,015.3 billion by 2025 from USD 1,430.5 billion in 2020, at
a CAGR of 7.1% during the forecast period. Growth in this market is
mainly driven by the rising prevalence of chronic diseases, growth in the
biologics market, and technological advancements and new product
launches. Due to the outbreak of corona virus globally, there is a sudden
rise in the demand for pharmaceutical drugs largely in infectious
application.’

Numbers in Sweden 2019: ~40 companies (90% SMEs), 2600

employees (8000 if AZ is fully accounted), 9 bn SEK net turnover (54 bn
SEK if AZ is fully accounted)
https://www.marketsandmarkets.com/Market-Reports/drug-delivery-technologies-market-
1085.html (accessed Aug 31, 2021) © 2021 Christel Bergström