Meta-Analysis

Method Description:
Meta analysis is a type of research method which entails collecting answers from multiple different studies and putting them together to get
a bigger picture. Meta-analysis uses both qualitative and quantitative analysis depending on what the studies in the analysis are
using. Meta-analysis is like gathering all those studies to see the whole picture, and it can use various methods depending on the studies
being analyzed.(10 points)

Your Research Topic:

My research topic is neurotechnology in the context of neuroethics. In my research, I will try to compare the ethics of different
neuroethical drugs and different technologies and their use in school. The field of neuroethics is a controversial field. When in the
context of neuroenhancement with the use of technology, many questions are raised based on the ethicality of everyday use and
safety concerns. This will need meta-analylsis because I do not have the resources to conduct research myself. The second reason is
that I am exploring ethics, which needs the input of experts. ( (10 points)
Advice:
If you're interested in comparing the results of different studies to see if they agree or disagree, meta- ❖ A three-minute primer on meta-analysis – The Science of
analysis is a useful tool for drawing conclusions .While meta-analysis is a powerful method, it comes with combining evidence across multiple studies to address a
some potential challenges and pitfalls to be aware of. One major concern is the "garbage in, garbage out"
research question. This source also gives examples of
principle, where including low-quality studies can lead to incorrect results. It's crucial to carefully evaluate
the studies you select. Another challenge is publication bias, where only studies with certain results get challenges such as potential bias, which can affect the
published, potentially skewing your meta-analysis. chances of the article getting published. The source explains
the meta-analysis through a sample prompt of aspirin
successfully reducing pain

Tarun Thalluru, Period 3

 Meta Analysis
Sample Papers & Description:
Videos & Description:
https://www.youtube.com/watch?v=WB9pbHqUs5c - Explains systematic
Ashish W. Khobragade, Nitin Agrawal ,Prevalence of Stress and Insomnia among Health Care reviews and meta-analysis. This video explains the steps to make a meta-
Workers in India during COVID-19 Pandemic: A Systematic Review and Meta-
analysis. Step 1 Define the question. Step 2 do a literature search. Step 3
analysis.10.4103/ijcm.ijcm_482_22. - The pandemic causes stress for healthcare workers.
Assessment of this stress can help create prevention strategies. The objective was to find pull articles and read abstracts. Step 4 read the full paper. Step 5 data
how many healthcare workers in India had stress and insomnia, then how to solve the issue abstraction. Then step 6 conduct analysis.
of stress. The paper implemented the method well as they had a methodology and were
able to compile a total of 23 studies analyzing stress and insomnia. Their results showed that https://www.youtube.com/watch?v=i675gZNe3MY – Explains what a meta-
1 in 3 healthcare workers in India suffered from stress and insomnia. analysis is,and defines it as compiling different results to give overall
results. They explain the meta-analysis in the context of how effective
Methylated Circulating Tumor DNA in Blood as a Tool for Diagnosing Lung Cancer: A
Systematic Review and Meta-Analysis. Morten Borg et al.10.3390/cancers15153959 - Lung aspirin is at relieving pain.
cancer is the leading cause of cancer related deaths. Current screening methods using
computed tomography have limitations. The paper successfully implemented the meta- youtube.com/watch?v=_IJSTE2lFzc – Explains how the Meta-analysis is a
analysis method by using databases such as MEDLINE, Embase, Web of Science, and
quantitative study design used to systematically assess the results of
Cochrane Library to systematically review and search for articles. The search string contained
three main topics: Lung cancer, blood, and methylated ctDNA. The extraction of the data was previous research to derive conclusions about that body of research. This
done by the reviewers and in total 33 studies were eligible. also works on the findings of single, independent studies, using statistical
methods to calculate an overall or ‘absolute’ effect.
Explanation of how the paper implements the method, along with evaluation of the use
of method (to what extent is the method aligned with the inquiry’s purpose?)

(30 points: Minimum of 2 papers required, 15 points each)

(30 points: Minimum of 3 videos required, 10 points each)

Tarun Thalluru, Period 3

 References

Borg, M., Wen, S. W. C., Andersen, R. F., Timm, S., Hansen, T. F., & Hilberg, O. (2023). Methylated Circulating Tumor DNA in Blood as a Tool for diagnosing Lung Cancer: A
Systematic Review and Meta-Analysis. Cancers, 15(15), 3959. https://doi.org/10.3390/cancers15153959

Khobragade, A., & Agrawal, N. (2023). Prevalence of Stress and Insomnia among Health Care Workers in India during COVID-19 Pandemic: A Systematic Review and Meta-
analysis. Indian Journal of Community Medicine, 48(4), 525–532. https://doi.org/10.4103/ijcm.ijcm_482_22

Rahul Patwari. (2014, June 2). Intro to Systematic Reviews & Meta-Analyses [Video]. YouTube. https://www.youtube.com/watch?v=WB9pbHqUs5c

Step By Step Metaanalysis For Beginners. (n.d.). YouTube. https://youtube.com/watch?v=_IJSTE2lFzc

TARG Bristol. (2017, November 13). A three minute primer on meta-analysis [Video]. YouTube. https://www.youtube.com/watch?v=i675gZNe3MY

Your Name, Class Period