Product

COSMETIC
ACTIVE INGREDIENTS Guide
with

People
Business

Planet
HOW TO READ
THIS DOCUMENT ORIGIN FORMULATION

Plant extract Water soluble

Water dispersible
Plant cell culture Oil soluble
Preservative free
according to the annex V of the
Synthetic EU regulation (EC) n°1223/2009

Supercritical CO2 CHINESE REGULATION

Biotechnology IECIC listed

Natural origin & organic content LABELS

% Values are given based on our Sederma is RSPO Raw material

interpretation of ISO 16128 Supply Chain Certified approved by Ecocert
standard. They are likely to (BVC-RSPO-FR042532) Greenlife, conform
evolve according to further approved to deliver to the COSMOS
discussions with the professional 2-0024-06-100-00 physically Certified Standard
federations of the Cosmetic Sustainable Palm Oil *: Several versions available
industry. derivates via Mass **: Contact us
Balance
Founded in 1964, Sederma became a member of the Croda International Group in 1997. Sederma is dedicated
to the development of active ingredients and the creation of innovative concepts for Personal Care and Cosmetic
products, based on the mastery of biotechnology, plant cell culture, fine chemistry and vegetal extraction.
Located near Paris, all Sederma activities, from R&D and manufacturing to administration and warehousing, are
gathered in a 11 000 m² complex.
Sederma is a world leader in the field of active ingredients intended for the Cosmetic industry. We have developed
a unique range of biochemical actives, with substantiated efficacy for wrinkle reduction, sebum regulation,
moisturisation, skin firming, free radical protection and a host of other benefits. We offer a wide range of cosmetic
ingredients for skin and hair care products which are internationally sold to all major cosmetic manufacturers.

Constant research of proven efficacy

Equipped with a high-performance and modern Claim Substantiation laboratory, Sederma uses powerful in vitro,
ex vivo and in vivo tests to prove the efficacy of the products.

Constant innovation at the service of Cosmetology

Since 1964, Sederma has been devoted to the development of active ingredients and the creation of innovative
concepts for the Cosmetic industry based on the mastery of biotechnology, plant cell culture, molecular synthesis
and vegetal extraction.

Production facilities at the forefront of technology

A team of competent researchers is responsible for the dynamism of the R&D laboratory. The Production workshop
and the Quality Control laboratory are equipped with modern and sophisticated equipment which ensures the constant
quality of our products.

Quality requirements
Sederma strives for continuous improvement of quality and service, it has received the following certifications:
ISO 14001, ISO 45001, ISO 9001, AEO, Cosmetic Ingredient Good Manufacturing Practice, RSPO and Halal.
Anti-ageing ORIGINFORMULATION IECIC

Optim Hyal® Smoothes the skin by stimulating hyaluronic acid neosynthesis and sustaining its turnover.

NG Gardenia Stems™ Protects the collagen network and stimulates its synthesis.

Majestem® Visible lifting action on the neck and face, for a majestic beauty.

Majestem® Drypure® Especially developed for powder make-up applications, protects and lifts the skin. Powder

Visibly fades signs of senescence. Enhances skin viscoelastic properties and brightens senile pigmented
Senestem®
spots.
Feminage® Natural derived ingredient protecting elastic tissue of menopausal women to fight against skin sagging.
Restores the epidermis integrity, stimulates collagen synthesis and fades age spots.
Měiritage™
Inspired from Traditional Chinese Medicine.
Skin Tightener ST2™ Marine and plant ingredients associated for an immediate tightening, lifting and firming effect.

Sterocare PH™ Red clover isoflavones to address the needs of mature skin.

PoreTect® Eco-designed ingredient that rejuvenates the skin texture by counteracting age-related pore sagging.

ReVitAlide™ Stable, highly bioavailable and well-tolerated encapsulated retinol for advanced skincare.

Biopeptide CL™ Collagen chain fragment to decrease wrinkles and reinforce the epidermis.

Biopeptide EL™ Chemotactic fragment of elastin that firms and restores the skin’s elasticity.

Dermaxyl® Anti-wrinkle repairing complex, based on the matrikine technology.

Idealift® Fights against skin sagging and improves resistance to gravity.

The Original. The first wrinkle filler peptide that have been successfully clinically tested for
Matrixyl®
6 months. The industry benchmark.
Matrixyl® 3000 Anti-wrinkle matrikine association that fights against photo-ageing and chrono-ageing. *
High-tech global anti-ageing ingredient that controls skin space-time continuum by acting on
Renovage™
the four dimensions of skin ageing: surface, depth and time.
Rigin™ Hydrates, protects and smoothes the skin in only 15 days. *
Essenskin™ Fortifies and restructures thin and fragile mature skin.
Visibly reduces the signs of ageing on the face and décolleté.
Juvinity™
Smoothes wrinkles, restructures and densifies the dermis.
Matrixyl® morphomics® Combats vertical lines by influencing dermal morphology and rebooting the skin’s connections.

Matrixyl® synthe’6® Powerful anti-wrinkle peptide acting on 6 skin-rebuilding essentials and tested with success on the forehead.

Dynalift™ Immediate and durable tightening effect resulting in smoothness and radiance of the skin.

Calming - Sensitive skin ORIGINFORMULATION IECIC

Bacocalmine PH™ Ayurvedic care for reactive and sensitive skin.

NG Shea
Soothes inflammation by strengthening the epidermis and restoring the barrier function.
Unsaponifiable™
Addresses both signs (unpleasant sensations, redness, dryness) and causes of sensitive and reactive
Pacifeel®
skin.
Siegesbeckia PH™ Anti-inflammatory, protection of collagen.
Messenger of happiness and muscle relaxation. Modulates perception of unpleasant sensations, enhances well
Calmosensine SP™
being, alleviates tension to prevent the onset of expression lines and wrinkles.
Subliskin™ Comfort and reinforcement of thin and fragile skin. **
GPI Lysine™ Counteracts glyc-inflamm-ageing caused by external aggressions and provides a fast soothing effect.
Brightening ORIGINFORMULATION IECIC

Keratoline C PS™ Brightening by enzymatic peeling, gentle alternative to AHAs.

O.D.A.white™ Specifically modulates the metabolism of melanocyte nucleus that reduces melanin synthesis.

Melaclear 2 NP™ Soft depigmentation by enzymatic peeling combined with melanin synthesis regulation.

Etioline™ Increases homogeneity of skin tone.

Melaslow PH™ Promotes complexion brightening and age spot depigmentation.

Wonderlight™ Helps decrease hyperpigmentation accentuated by age and stress.

Arbutin™ Molecule with brightening properties.

Lumiskin™ Upstream regulation of tyrosinase synthesis for a brightening effect on dark skin.

Lumisphere™ Instant and long term skin brightener with a soft focus effect on lines, pores and imperfections.

Energising
Chronodyn™ Chronobiological cell energiser, tones and firms the skin, reduces signs of fatigue.

Hydrergy PH™ Moisturising and energising, rich in vitamins. Smoothing effect.

Oxylastil® PH™ Cell oxygenation for an anti-ageing efficacy.

Energisome Q10 PH™ Vectorised Coenzyme Q10, stimulation of cell respiration.

Eye care
Ameyezing™ Lessens both hyperpigmented and vascular dark circles.

NG Echinacea Stems™ Prevents collagen loss and reduces capillary permeability to lessen dark circles.

Eyeliss™ Reduces bags and puffiness under the eyes.

Fights against the accumulation of blood degradation products around the eyes to decrease dark
Haloxyl®
circles.
Helps eyelashes appear longer, fuller and stronger by promoting follicle keratinocyte proliferation
Widelash®
and ensuring optimal anchorage.

Environmental protection
Fights against visible and invisible pollution damage to the skin. Protects, removes, strengthens and
Citystem®
repairs.
Venuceane™ Anti-ageing active offering protection against both UV and IR damage.

Synchrolife® Resynchronises cellular life to uplift skin beauty and wellbeing.

Bacocalmine PH™ Free radical scavenger, protects from inflammation.

Měiritage™ Reinforces the barrier function and counteracts the oxidative stress from UV and pollution.

Osmopur™ Protecting complex against smoke and heavy metals.

Pacifeel® Improves skin resilience, helps sensitive and reactive skin to fight against environmental aggressions.

FruitBio™ A natural treatment against pollution particle adhesion on the hair.

A prebiotic nutrient complex that rebalances the cutaneous microbiota to restore the skin well-being
Ecodermine™
and harmony.
Resistem® Stimulates skin hormetic defence to promote detoxification and tissue regeneration.
Hair care ORIGINFORMULATION IECIC

Apiscalp® Restores scalp integrity to provide purity and comfort for a happy scalp.

FruitBio™ Smoothes the hair cuticles to strengthen and protect the hair fibre.

Heliogenol™ Protects against free radical damage on dyed and natural hair.

Ceramide A2 PH™ Reinforces hair sheath, protects and repairs hair from chemical aggressions.

Hairspa™ Soothes and moisturises the scalp, relieves scalp discomfort.

Capigen SP™ Prevention of hair loss and normalisation of sebum secretion.

Procapil® Cell dynamics promote hair anti-ageing and prevent hair loss for men and women.

Silverfree™ Presents a long-lasting hair re-pigmentation effect for the freedom to choose how to age.

Lip care
NG Shea
Repairs damaged lips. Rich in unsaponifiables.
Unsaponifiable™
Maxi-Lip™ Brings volume and moisture, smoothes lip contours.

Volulip™ Lip plumper with anti-ageing and hydration effects.

Moisturising & Nourishing

Hydronesis® Natural body beautifier that acts against keratosis pilaris and post-waxing redness.

DNA Gel PH™ Moisturising and cell repair for skin elasticity and suppleness recovery.

Hydraprotectol SP™ All the benefits of snail mucus for a long-lasting and in-depth hydration.

Ichtyocollagen PH™ Native fish collagen with film-forming and moisturising properties.

Oligoceane PH™ Provides oligo-elements and mineral salts for the maintenance of cellular life.

Birch sap PH™ Oligo-elements for cutaneous firmness and moisturisation, especially for men.
Compensates cutaneous lipid deficiencies, decreases water loss; also tested in loose powder for make-up
Lipexel™
application.
Moist 24 PH™ 24-hour long-lasting moisturiser, creates water supplies. *
NG Shea
Strengthens the epidermis, restores barrier function and improves moisture level.
Unsaponifiable™
Vegesome® Moist 24™ Adds moisturising benefits to powder make-up. Powder

Ceramide 2™ Cutaneous barrier regeneration, identical to natural ceramide of the skin.

Ceramide HO3™ Reinforcement of the cutaneous barrier and of the cellular cohesion.

Osmocide 4™ Moisturises and allows to formulate with less preservatives.

Aqualance™ Osmoprotectant skin moisturiser for a progressive rehydration of the various skin layers.

Revidrate® Recreates the skin’s own natural moisture by supporting the water and lipid balance in the epidermis.

Nail care
Nail pampering perfector: helps to improve nail thickness, cohesion and hydration while smoothing the
Neonyca®
surface.
Radiance and skin uniformity ORIGINFORMULATION IECIC

BB-Biont™ Biomimetic peptide healing the holobiont for a blemish-banned, smooth and healthy skin

Crystalide® This bio-highlighter peptide makes the skin clear, uniform and glowy just like a piece of crystal.

Kombuchka PH™ Improvement in skin quality (smoothing, radiance), anti-glycation, lipofilling effect.

Phytotonine™ Regulates the cutaneous microcirculation to reduce skin redness and improve luminosity.

NP Divatonyl™ Refines skin grain for a mattifying effect and radiance enhancement.

Rubistem® Helps reduce first signs of rosacea. Recreates a lucid complexion.

This eco-designed and ultra-customised active ingredient provides a lucent and healthy amber tone to
Amberstem®
olive complexions.
Resistem® Decreases skin redness and enhances natural skin glow thanks to an hormesis-like mechanism.

Chromocare™ Evens and rejuvenates skin complexion by fighting against oxidative stress.

Seboregulating
Sebuless® Mattifies and equalises skin complexion of oily and acne-prone skin.

Normaseb PH™ Normalisation of the sebaceous activity.

Sebomine PTG™ Regulates the cutaneous microflora of oily and acne-prone skin.

Evermat™ Pore size, skin shine and sebum flow reduction.

Ac.net™ Holistic treatment for oily and acne-prone skin.

Silhouette sculpture
Legance® Global anti-ageing for legs, improves the appearance and comfort of the legs.

Zingerslim® Oil soluble fat burner, encourages drainage of fat.

Esculoside™ Pure molecule with veinotonic and anti-inflammatory properties.

Phytotonine™ Microcirculation regulation to relieve heavy legs.

Pleurimincyl™ Medicinal Chinese plant stimulating lipolysis through Protein G activation.

Redulite™ Fights against water retention.

Unislim PH™ Contouring effect for men and women by a cholesterol-mimetic action.

Volufiline™ Helps promote body volume by stimulating adipose tissue formation.

Lipocare™ Reduces «orange peel» appearance of skin and increases skin firmness.

Bio-bustyl PH™ Bust and body firming complex.

Bodyfit™ Fights against adipose tissue by cellular reverse differentiation.

Ovaliss™ Reduces and contours the double chin.

Vexel SP™ Firming and slimming nanovesicles.

Phytosonic™ Adipocyte shedding by ultrasound-like effect.

Intenslim® Natural fat burner, fights fat accumulation, particularly on the stomach area.

Hydronesis® Natural body beautifier that acts against keratosis pilaris and post-waxing redness.
Stretch marks ORIGINFORMULATION IECIC

Regestril™ Association of two matrikines to prevent and repair stretch marks.

Darutoside™ Ethnobotanical molecule to prevent and repair stretch marks. **

Tan accelerator
Tyr-Excel™ Promotes tanning speed and intensity. Improves moisture retention.

Pilosity
Capislow PH™ Moderates regrowth of unwanted body hair. Anti-inflammatory effect.

Kelisoft™ Slows down hair growth speed, refines hair diameter and calms down inflammation. *

ReVitAlide ™

Hero encapsulated retinol

for advanced skincare

ReVitAlide™ improves retinol delivery into the skin

and preserves its biological activity.
Wrinkle appearance is tremendously reduced at levels
as low as 0.09 % active retinol after 2 months of application.
 At Sederma, we are Actively Committed to minimise our social and environmental
impacts on our stakeholders without compromising innovation, quality and safety in line
with Croda CSR strategy.
We have put all our efforts for many years now to set-up a holistic view of doing Business
by placing equal emphasis on the Planet, People and profit. As a result, we can ensure
consistency between our product portfolio and our internal CSR policy management.

Ethical sourcing Eco-designed processes Dialogue with our stakeholders

Ethics at work Sustainable sourcing Strong certification policy
Safety Waste management Evaluation of processes / products / services
Well being at work Reduction of impacts on biodiversity and climate
End-consumer safety first

Green Brochure
This Green brochure lists the products from our catalogue with a natural origin content higher or equal to 75 %
and with interesting CSR credentials: eco-designed production process, ethical and sustainable sourcing, third party
certifications and impact calculations or greener analytical methods, … All these data are available upon request to your
sales representative.
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Anti-ageing Calming - Sensitive skin
NG Shea
Optim Hyal® 97.9 0 100 100
Unsaponifiable™
Majestem® 100 0 Pacifeel® 100 0
Majestem ®
100 0
Drypure® Siegesbeckia PH™ 98.87 0
NG gardenia Stems™ 100 0
Subliskin™ 97.8 0
Senestem® 100 0

Dynalift™ 83.4 0
Energising
Feminage® 100 0
Chronodyn™ 98.89 0
Chronodyn SP™ 99.1 0
Měiritage™ 100 0
Hydrergy PH™ 98.56 0
PoreTect® 100 0
Oxylastil® PH™ 78.37 0
Skin Tightener ST2™ 96.41 0

Sterocare PH™ 82 0

Eye care
Brightening
NG Echinacea Stems™ 100 0
Melaclear 2 NP ™
98 0
Ameyezing™ 100 0
Melaslow PH™ 98.56 0

Wonderlight™ 100 0
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Environmental protection Nail care
Citystem® 100 0 Neonyca® 100 0
Venuceane ™
98.9 0
Venuceane SP ™
99 0

Měiritage 100 0
Pilosity
™

Pacifeel
®
100 0
Kelisoft OS™ 89.97 0
FruitBio™ 99.08 0

Synchrolife® 99.9 0

Ecodermine™ 100 0
Radiance
Kombuchka PH™ 97.39 0
Resistem® 99.91 0 NG Kombuchka™ 99.4 0

Amberstem® 100 0

Resistem® 99.91 0

Hair care Rubistem® 100 0

Apiscalp® 100 0

FruitBio™ 99.08 0
Seboregulating
Hairspa™ 100 0
Sebuless® 100 0

Normaseb PH™ 98.7 0

Lip care Sebomine PTG™ 98.91 0

NG Shea NG Evermat™ 100 0

100 100
Unsaponifiable™

Moisturising & Nourishing Silhouette sculpture

Hydronesis® 100 0 NG Legance® 100 0

DNA Gel PH™ 98.69 0 Hydronesis® 100 0

Hydraprotectol SP™ 99.59 0 Phytosonic™ 99.09 0

Ichtyocollagen PH™ 88.35 0 Redulite™ 80.30 0

Oligoceane PH™ 84.56 0

Birch sap PH™ 98.56 83.24

NG Birch sap ™
99.50 84.43
NG Shea
100 100
Unsaponifiable™
Vegesome® Moist 24™ 87.94 0

Aqualance™ 99.2 0
 Plant Cell Culture Active Ingredients
How to combine efficacy, sustainability and safety? With Plant Cell Culture of course!
Plant cell culture is an eco-designed technology that exploits the power of synthesis from vegetal cells. Only a small
amount of plant tissue is required to obtain undifferentiated cells that are then activated to produce bioactives in response
to environmental and biological attacks. Sederma has developed an in-depth know-how in elicitation and characterisation
of these molecules of interest to offer ingredients with defined and reproducible composition as well as guaranteed efficacy.

Anti-ageing FORMULATION IECIC Eye care FORMULATION IECIC

NG Gardenia Stems™ NG Echinacea Stems™

Majestem®

Majestem® Drypure® Radiance

Senestem® Amberstem®

Resistem®
Environmental protection Rubistem®
Citystem®

Resistem® Seboregulating
Sebuless®

ERI 360 is an Eco social responsible ingredient label for the cosmetic market. It’s a monitoring tool which
evaluates raw materials, supply chains and processes as well as practices through 100 SMART eco social
indicators.

Products in compliance with

COSMOS MASS BALANCE
Amberstem® NG Legance® Apiscalp® Matrixyl®
NG Shea BB-Biont™ Matrixyl 3000® OS
Ameyezing™
Unsaponifiable™
Apiscalp® PoreTect® Bio-Bustyl PH™ Matrixyl®synthe’6®

Citystem® Rubistem® Biopeptide CL™ Maxi-Lip™

Ecodermine™ Sebuless® Biopeptide EL™ Neonyca®

Feminage® Senestem® Bodyfit™ Ovaliss™

Hairspa™ Crystalide® PoreTect®

Hydronesis® Essenskin™ Renovage™

Majestem® Eyeliss®/Eyeliss® PH™ Revidrate®

Majestem® Drypure® Haloxyl®/Haloxyl® PH™ Rigin®/NP-Rigin®

Měiritage™ Raw material approved by Ecocert Juvinity™ Synchrolife®

Greenlife, conform to the COSMOS
Neonyca® standard Kelisoft OS™ Volulip™

NG Echinacea Stems™ Lipexel™ Wonderlight™

NG Evermat™ Lumiskin™ Zingerslim®

2-0024-06-100-00

NG Gardenia Stems™ Lumisphere™

Sederma is RSPO Supply Chain Certified (BVC-RSPO-FR042532) approved to
NG Kombuchka™ deliver physically Certified Sustainable Palm Oil derivatives via Mass Balance. More
products will be added to this list shortly, please contact your sales representative
for more information.
 sederma

SEDERMA SAS
29 rue du Chemin Vert
F-78612 Le Perray en Yvelines cedex
tel ++ 33 1 34 84 10 10
sederma@sederma.fr www.sederma.com

Smart science to improve lives™

SEDERMA Inc
777 Scudders Mill Road
Building 2 suite 200
Plainsboro, NJ 08536 - USA
tel ++ 1 (609) 212 2500
sederma-usa@croda.com www.sederma.com

SEDERMA GmbH
Herrenpfad-Süd 33
41334 Nettetal Germany
tel ++ 49 21 57 817318
sederma@sederma.de www.sederma.com

Non-warranty: The information in this publication is believed to be accurate and is

given in good faith, but no representation or warranty as to its completeness or accuracy
is made. Suggestions for uses or applications are only opinions. Users are responsible
for determining the suitability of these products for their own particular purpose. No
representation or warranty, expressed or implied, is made with respect to information or
products including, without limitation, warranties of merchantability, fitness for a particular
purpose, non-infringement of any third party patent or other intellectual property rights
including, without limit, copyright, trademark and designs. Any trademarks identified herein, Part of Croda International Plc.
unless otherwise noted, are trademarks of the Croda group of companies. ©2023 Sederma

Oct 2022 01/23 PCS PG CAT-04 V11 EN