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Ciprofloxacin

Brand Name
Generic Name Cipro
February 25, 2023
Date Ordered
Rationale for the This drug ordered with a patient have UTI.
Drug Order
Classification Fluoroquinolones
Actual Dose/ 500mg 1 cap tablet BID x 7 days.
Frequency/ Route
Use in patients with acute sinusitis, acute exacerbations of chronic
bronchitis, and acute uncomplicated UTI isn’t recommended because
Indication
of risk of serious adverse effects, use in these patients only when there
are no other treatment options.
Mechanism of Inhibits bacterial DNA synthesis, mainly by blocking DNA gyrase,
Action bactericidal.

Ciprofloxacin tablet, suspension is contraindicated in patients who


have shown hypersensitivity to Ciprofloxacin, or other quinolone
Contraindication
antibacterial agents or any of the excipients.

muscle weakness, pain or abnormal sensations, severe tiredness


Side Effects
faster or irregular heartbeat, confusion, restlessness, diarrhea, nausea
and vomiting.
Adverse Reactions Dizziness, severe headache, fast or irregular heartbeat, feeling faint or
lightheaded, chest pain, trouble breathing.
 Ensure the rights of medication administration.
 Assess history of allergy to ciprofloxacin.
Nursing  Document administration.
Considerations/  Monitor the vital signs.
Responsibilities  Tell patient not to divide tablets but take them whole, with
food or shortly after meal.
 Instruct patient to take drug before or after meals.
Celecoxib
Brand Name
Generic Name Celebrex
Date Ordered
Rationale for the This drug ordered use to relieve pain.
Drug Order
Classification NSAIDS COX-2 inhibitors
Actual Dose/ 200 mg capsule.
Frequency/ Route
The FDA recommends celecoxib and other NSAIDs (non-steroidal
Indication anti-inflammatory drugs), along with acetaminophen, as first-line
analgesics for patients with osteoarthritis and rheumatoid arthritis.
Mechanism of Selective Inhibition of cyclooxygenase-2 (COX-2)
Action

Contraindicated in patients hypersensitive to drug, sulfonamides,


Contraindication aspirin, or other NSAIDS.
Drug isn’t recommended with any dose of a non-aspirin NSAIDS.

Shortness of breath or difficulty breathing, diarrhea, nausea, excessive


Side Effects
tiredness, unusual bleeding or brushing, itching, headache, dizziness,
dyspepsia.
Adverse Reactions Dizziness, headache, diarrhea, nausea, abdominal pain, insomnia,
peripheral edema, sinusitis.
 Ensure the rights of medication administration.
 Assess history of allergy to celecoxib
 Document administration.
Nursing
 Monitor the vital signs.
Considerations/
 Instruct patient to notify prescriber about rash, loose stools,
Responsibilities
diarrhea, or evidence of superinfection.
 Advise patient receiving drug IV to report discomfort at IV
site.
Flagyl R
Brand Name
Generic Name Metronidazole
Date Ordered
Rationale for the This drug ordered is a antibiotic that is used to treat a wide variety of
Drug Order infections of patient.
Classification Nitroimidazoles, antimicrobials.
Actual Dose/ 500 mg 1-tab TID x 7 days.
Frequency/ Route
Use metronidazole only for the conditions for which it’s indicated
because it may be carcinogenic. Avoid unnecessary use.
Indication

Mechanism of Direct- acting trichomonacide and amebicide that works inside and
Action outside the intestines. Its thought to enter the cells of microorganisms
that contain nitro reductase.
Contraindicated in patient’s hypertensive to drug or other
Contraindication nitroimidazole derives. The use of disulfiram with 2 weeks of
metronidazole therapy use of alcohol.

Side Effects
Nausea, vomiting, diarrhea, constipation, upset stomach, stomach
cramps, loss of appetite.

Adverse Reactions
Nausea, vomiting, diarrhea, constipation, seizures, fever, vertigo, ataxia,
abdominal pain, irritability, weakness, insomnia.
 Ensure the rights of medication administration.
 Assess history of allergy to metronidazole
 Document administration.
Nursing
 Monitor the vital signs.
Considerations/
 Instruct patient to take drug exactly as prescribed and with
Responsibilities
meals.
 Tell patient to report all adverse effects reactions, especially
shortness of breath
 Advise patient to inform or prescriber about use of this drug
before procedures or surgery.
Brand Name Rifater

Generic Name
Isoniazid
Date Ordered
Rationale for the This drug ordered use to treat tuberculosis infection.
Drug Order
Classification Antituberculotic Agents
Actual Dose/ 3 tablet 30 min-1hr
Frequency/ Route

Isoniazid is used for the treatment of all forms of tuberculosis in which


Indication
organisms are susceptible. It is also used in combination with rifampin
and pyrazinamide.

Mechanism of Isoniazid is a prodrug and must be activated by bacterial catalase.


Action Specifically, activation is associated with reduction of the
mycobacterial ferric KatG catalase-peroxidase by hydrazine and
reaction with oxygen to form an oxyferrous enzyme complex.
Contraindication Isoniazid is contraindicated in patient who is developing severe
hypersensitivity reaction.
 Clumsiness or unsteadiness, nausea, vomiting, numbness,
tingling, or pain in hands and feet, yellow eyes or skin,
Side Effects unusual tiredness, or weakness, fever and sore
throat.

 Clumsiness or unsteadiness, nausea, vomiting, numbness,


Adverse Reactions tingling, or pain in hands and feet, yellow eyes or skin,
unusual tiredness, or weakness, fever and sore
throat, seizures.
 Ensure the rights of medication administration.
 Assess history of allergy to isoniazid.
 Document administration.
Nursing  Monitor the vital signs.
Considerations/  Instruct patient to report all adverse reaction and notify the
Responsibilities prescriber immediately of the symptoms of overdose or allergic
reaction occur.
 Always check the expiry date of the medicines.
Brand Name Prilosec
Generic Name
Omeprazole
Date Ordered
This drug ordered use to treat indigestion and heartburn and acid
Rationale for the
reflux.
Drug Order
Classification Proton- pump inhibitors
Actual Dose/ 40mg IV OD
Frequency/ Route

Treatment of active duodenal ulcer in adults

 Eradication of Helicobacter pylori to reduce the risk of


duodenal ulcer recurrence in adults.

 Treatment of active benign gastric ulcer in


adults
Indication
 Treatment of symptomatic gastroesophageal
reflux disease (GERD) in patients 1 year of age
and older

 Treatment of erosive esophagitis (EE) due to


acid-mediated GERD in patients 1 month of age
and older

Hydrochloric acid (HCl) secretion into the gastric lumen is a process


Mechanism of regulated mainly by the Pase of the proton pump expressed in high
Action quantities by the parietal cells of the stomach. ATPase is an enzyme on
the parietal cell membrane that facilitates hydrogen and potassium
exchange through the cell, which normally results in the extrusion of
potassium and formation of HCl.
patients with a history of hypersensitivity to the drug or any excipients
Contraindication
from the dosage form.

Side Effects Headache, nausea and vomiting, stomach pain, constipation, flatulence, loss
weight dizziness, back pain weakness, diarrhea.
Adverse Reactions Headache, nausea and vomiting, stomach pain, constipation, flatulence, loss
weight dizziness, back pain weakness, diarrhea.
 Ensure the rights of medication administration.
 Assess history of allergy to omeprazole
 Document administration.
 Monitor the vital signs.
 Advise patient to notify prescriber about bothersome side
Nursing
effects.
Considerations/
 Always check the expiry date of the medicines.
Responsibilities
 Explain that taking drug doesn’t reduced the importance of
following recommended diet and exercise plan.
 Remind patient of the need for follow up blood work to
evaluate progress.
REFERENCES

1. Li XQ, Weidolf L, Simonsson R, Andersson TB:


Enantiomer/enantiomer interactions between the S- and R-
isomers of omeprazole in human cytochrome P450 enzymes:
major role of CYP2C19 and CYP3A4. J Pharmacol Exp Ther. 2005
Nov;315(2):777-87. Epub 2005 Aug 10. [Article]
2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers,
inhibitors and structure-activity relationships of human
Cytochrome P450 2C9 and implications in drug development. Curr
Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [Article]
3. Botsch S, Gautier JC, Beaune P, Eichelbaum M, Kroemer HK:
Identification and characterization of the cytochrome P450
enzymes involved in N-dealkylation of propafenone: molecular
base for interaction potential and variable disposition of active
metabolites. Mol Pharmacol. 1993 Jan;43(1):120-6. [Article]
4. Turpeinen M, Uusitalo J, Jalonen J, Pelkonen O: Multiple P450
substrates in a single run: rapid and comprehensive in vitro
interaction assay. Eur J Pharm Sci. 2005 Jan;24(1):123-32.
[Article]
5. Park EJ, Cho HY, Lee YB: Effect of Cimetidine and Phenobarbital
on metabolite kinetics of Omeprazole in rats. Arch Pharm Res.
2005 Oct;28(10):1196-202. [Article]
6. Zhou Q, Zhou S, Chan E: Effect of omeprazole on the
hydroxylation of warfarin enantiomers in human: in-vitro studies
with liver microsomes and cDNA-expressed cytochrome P450
isozymes. Curr Drug Metab. 2005 Oct;6(5):399-411. [Article]
7. Roymans D, Van Looveren C, Leone A, Parker JB, McMillian M,
Johnson MD, Koganti A, Gilissen R, Silber P, Mannens G,
Meuldermans W: Determination of cytochrome P450 1A2 and
cytochrome P450 3A4 induction in cryopreserved human
hepatocytes. Biochem Pharmacol. 2004 Feb 1;67(3):427-37. doi:
10.1016/j.bcp.2003.09.022. [Article]
8. Abelo A, Andersson TB, Antonsson M, Naudot AK, Skanberg I,
Weidolf L: Stereoselective metabolism of omeprazole by human
cytochrome P450 enzymes. Drug Metab Dispos. 2000
Aug;28(8):966-72. [Article]
9. Tassaneeyakul W, Vannaprasaht S, Yamazoe Y: Formation of
omeprazole sulphone but not 5-hydroxyomeprazole is inhibited by
grapefruit juice. Br J Clin Pharmacol. 2000 Feb;49(2):139-44.
[Article]
10. Shirasaka Y, Sager JE, Lutz JD, Davis C, Isoherranen N:
Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites
and their contribution to drug-drug interactions. Drug Metab
Dispos. 2013 Jul;41(7):1414-24. doi: 10.1124/dmd.113.051722.
Epub 2013 Apr 25. [Article]
11. Prilosec FDA label [File

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