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Acknowledgments
Preface
Citation
BASICS II and the Pan American Health Organization. Selected Annotated Bibliography on Newborn Health: Evidence-based
Information for Developing Country Programs Including Public Health Aspects. Published by the Basic Support for Institutionalizing
Child Survival Project (BASICS II) for the United States Agency for International Development. Arlington, Virginia, February 2004.
BASICS II
BASICS II is a global child survival project funded by the Office of Health and Nutrition of the Bureau for Global Health of the U.S.
Agency for International Development (USAID). BASICS II is conducted by the Partnership for Child Health Care, Inc., under
contract no. HRN-C-00-99-00007-00. Partners are the Academy for Educational Development, John Snow, Inc., and Management
Sciences for Health. Subcontractors include Emory University, The Johns Hopkins University, The Manoff Group, Inc., the Program
for Appropriate Technology in Health, Save the Children Federation, Inc., and TSL.
The Organization’s essential mission is to strengthen national and local health systems and improve the health of the peoples of the
Americas, in collaboration with Ministries of Health, other government and international agencies, non-governmental organizations,
universities, social security agencies, community groups, and many others.
This document does not necessarily represent the views or opinion of USAID. It may be reproduced if credit is properly
given.
Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .iii
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .v
2. Selected Maternal Health Aspects with Direct Impact on Newborn Health, Including
Antenatal Care and Prevention of Low Birthweight
General Aspects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .17
Maternal Nutrition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .39
Maternal Infections . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .59
Prevention of Maternal and Neonatal Tetanus . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .67
Malaria in Pregnancy and Impact on the Newborn Infant . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .75
TABLE OF CONTENTS
1. Although abstracts are grouped in different sections, there is obviously some overlap between categories. Readers are requested to check
other relevant sections as well.
2. For Traditional Birth Attendant (TBA) training materials, see also section on Capacity Building, Including Training Materials/Tools.
3. Included articles are primarily relevant to breastfeeding in the newborn and promotion of breastfeeding at the community level. Other
articles relevant to older children are not included but may be found in the PAHO Infant Feeding Bibliography. See also the section on
Mother-to-Child Transmission of HIV/AIDS.
i
Acknowledgments
T
his document, prepared in collaboration by the Basic Support for Institutionalizing Child Survival
(BASICS II) Project and the Pan American Health Organization (PAHO), would not have been possible
without the contributions of several individuals to its realization, including Indira Narayanan, Naomi
Brill, Misun Choi, Mandy Rose, Mariela Aguilar, Andrés Acedo, Silvana Faillace, Mireille Cronin Mather,
Kathy Strauss, Munira Siddiqi, Amy Martin, Jeff Pelletier, and Greg Wilson from BASICS II, and Yehuda
Benguigui, Rolando Cerezo Mullet, Gerardo Cabrera-Meza, Helia Molina, René Salgado, and Lourdes
Barrios from PAHO.
ACKNOWLEDGMENTS
iii
Preface
I
nfant mortality in developing countries has decreased significantly during the last two decades. Much of
the decrease is due to reductions in mortality in the post-neonatal period, that is, between four weeks and
one year of age. Neonatal mortality has not decreased to the same extent and in some countries has
remained relatively static. Currently, about 60% of infant deaths take place within the first month, and of
these, about 60% take place within the first week. If the Millennium Development Goals for infant mortality
are to be achieved, this brief but critical period of life needs to be addressed.
The leading causes of deaths in older infants and in the newborn period differ. In older infants, over
70% of deaths are due to pneumonia and diarrhea, with malnutrition serving as a major underlying factor.
The major causes of death in newborn infants include infections (32%), birth asphyxia (29%), and
complications of prematurity (24%) with low birthweight being an underlying factor. Simple, low-cost
interventions can prevent many of the problems and deaths in the newborn period.
Neonatal health is closely linked to reproductive health and child survival and development. A
significant number of babies in developing countries are born at home. Care-seeking is often limited and
inappropriate in the home, resulting in a number of deaths. Therefore, in addition to advocacy for suitable
policies, resources, and other systems-strengthening initiatives, community- and family-based interventions,
including promotion of optimal behaviors, should be key components of programs to improve newborn
health.
Furthermore, in many developing countries, pre-service education for medical and paramedical staff
includes very little if any training related to newborn health. Training in the practical aspects of newborn care
is particularly absent. As a result, health workers are ill-equipped to handle even the most basic health issues
of the newborn infant. Basic newborn care is a requisite for all babies and requires simple interventions that
include a number of behavior change approaches. At the same time, the components of this care should be
evidence-based to the extent possible.
This document is concerned with aspects of neonatal and maternal health that are likely to have a direct
impact on the baby. Although it was prepared for the Latin America and Caribbean (LAC) region, these
aspects are relevant to many health facilities and communities in developing countries. This bibliography
includes summaries of relevant program experiences and available evidence for some components of newborn
care. It includes abstracts of articles from journals, as well as references to some resource materials, tools,
and documents published by various organizations.
The abstracts are divided into sections according to the table of contents. Some abstracts are related to
more than one topic. For example, some references on cord care are listed not only under the main section on
cord care but also under prevention of maternal and neonatal tetanus, and some references on breastfeeding
are also included under mother-to-child transmission of HIV/AIDS.
This bibliography is not meant to be an exhaustive review but rather to highlight information of
relevance to technical personnel such as health providers, organizations, and stakeholders interested or
involved in implementing newborn health interventions at facility and community levels.
PREFACE
v
1. Background and General Aspects
Background and General Aspects
Bang, A. T., R. A. Bang, S. Baitule, M. Deshmukh, Abstract: OBJECTIVE: To assess maternal and
and M. H. Reddy. 2001. “Burden of neonatal health services in 49 developing countries.
morbidities and the unmet need for health care METHODS: The services were rated on a scale of
in rural neonates—a prospective observational 0 to 100 by 10–25 experts in each country. The
study in Gadchiroli, India,” Indian Pediatr., ratings covered emergency and routine services,
vol. 38, no. 9, pp. 952–965. including family planning, at health centers and
district hospitals, access to these services for both
Abstract: BACKGROUND: Majority of the
rural and urban women, the likelihood that women
neonates in developing countries are born and
would receive particular forms of antenatal and
cared for in rural homes but the available
delivery care, and supporting elements of programs
information is mostly hospital based.
such as policy, resources, monitoring, health
OBJECTIVES: To estimate: (i) the incidence of
promotion and training. FINDINGS: The average
various neonatal morbidities and associated case
rating was only 56, but countries varied widely,
fatality in home-cared rural neonates,
especially in access to services in rural areas.
(ii) proportion of neonates with indications for
Comparatively good ratings were reported for
health care, and (iii) the proportion who actually
immunization services, aspects of antenatal care
receive it. DESIGN: Prospective observational
and counseling on breastfeeding. Ratings were
study. SETTING: Rural homes. METHODS:
particularly weak for emergency obstetric care in
Neonates in 39 study villages in the Gadchiroli
rural areas, safe abortion and HIV counseling.
district (Maharashtra, India) were observed during
CONCLUSION: Maternal health program effort in
one year (1995–1996) by 39 trained female village
developing countries is seriously deficient,
health workers at birth and during neonatal period
particularly in rural areas. Rural women are
(0–28 days) by making eight home visits. A
disadvantaged in many respects, but especially
physician checked the data and the morbidities
regarding the treatment of emergency obstetric
were diagnosed by a computer program. Vital
conditions. Both rural and urban women receive
statistics in these villages was independently
inadequate HIV counseling and testing and have
collected. RESULTS: Out of 1,016 live births,
quite limited access to safe abortion. Improving
95% occurred at home and 763 (75%) neonates
services requires moving beyond policy reform to
were observed. The agreement between
strengthening implementation of services and to
observations by health workers and physician was
better staff training and health promotion.
92%. Total 48.2% neonates suffered high risk
Increased financing is only part of the solution.
morbidities (associated case fatality >10%),
72.2% suffered low risk morbidities, and 17.9%
gained inadequate weight (less than 300g). Cartlidge, P. H. and J. H. Stewart. 1995. “Effect of
Seventeen percent neonates developed clinical changing the stillbirth definition on evaluation
picture suggestive of sepsis. Though 54.4% of perinatal mortality rates,” Lancet, vol. 346,
neonates had indications for health care and 38 out
3
survivors and 93 deaths (52 stillbirths, 36 neonatal education; improved treatment of syphilis,
deaths [28 early, 8 late], and five postneonatal hypertension, diabetes, and amniotic fluid
deaths). 119 babies had a birthweight below 500g; infection; closer monitoring of the fetal condition
one survived and 24 were perinatal deaths. Of the during labor; and proper management of abnormal
36 late neonatal deaths all were attributed to labor would reduce perinatal deaths. Premature
perinatally related events. Increased survival of infants are at greater risk of death than are
infants at 24–27 weeks’ gestation emphasizes the intrauterine growth retarded infants. Research is
importance of including all these infants in the needed to learn more about the epidemiology,
perinatal mortality rate, but it would be a more causes, and sequelae of asphyxia as well as the
useful measure of the effectiveness of perinatal care most cost-effective interventions. 38% of newborns
if it excluded babies below 500g, and included late at a hospital in Kathmandu had mild or moderate
neonatal deaths. hypoglycemia, 44% of whom experienced at least
three hypoglycemic episodes in the first two days.
Department of Child Health, University of Wales
Known hypoglycemic risk factors are low
College of Medicine, Cardiff, UK.
birthweight and hypothermia. Possible
hypoglycemic risk factors are prelactal feeds and a
Child Health Research Project. 1999. Reducing delay in beginning breastfeeding. Effective perinatal
perinatal and neonatal mortality. Report of a health care in developing countries requires a tired
meeting. system of referral and a motivated community
health worker trained to manage safe delivery and
Abstract: The World Health Organization estimates newborn care. Unfriendly staff and user charges are
that more than nine million infants die before birth obstacles to primary perinatal health care, however.
or in the first few weeks of life each year, and that UNICEF’s Baby Friendly Hospital initiative aims to
nearly all of these deaths occur in developing stop distribution of free infant formula in
countries. Most of these deaths are caused by maternity wards and to improve perinatal care.
infectious diseases; pregnancy-related complications
such as placent previa and abruptio placentae;
delivery-related complications, including Costello, A. and D. Manandhar. 1999. Improving
intrapartum asphyxia, birth trauma, and premature newborn health in developing countries.
birth. Sadly, very few programs currently exist to London: Imperial College Press.
specifically target perinatal and neonatal mortality.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
4
– Cost-Effective Essential Newborn Care in Poor in newborn care. Education of parents and young
Communities: The Evidence-Base Improving children holds the key to progress.
Health Service Delivery
Department of Perinatal Medicine and Child
– Challenges for Future Policy Implementation
Health, University of Bristol, UK.
and Research
5
(IAMANEH) 1997 conference. The editorial opens (6.0%) were less significant (11.1%). Tetanus was
by describing IAMANEH as a non-profit the cause of death for 21.7% and 17.1% of all
nongovernmental organization (NGO) created in infant deaths in FATA and NWFP respectively. The
1977 to improve maternal and neonatal health results suggest that there should be a shift in child
worldwide. IAMANEH is a federation of survival programs to give greater emphasis to
approximately 36 national societies and is different maternal and neonatal health, in particular to
from other international associations in this area maternal tetanus immunization, safe delivery and
because it clearly prioritizes developing countries cord care.
and is based in NGOs. IAMANEH conferences are
Available at:
distinguished by the fact that they are organized to
http://www.who.int/bulletin/pdf/2002/bul-4-E-
draw attention to a specific theme; for 1997, this
2002/80(4)271-276.pdf
was the social, cultural, and technological
determinants of maternal and neonatal health. The
proceedings of this conference deal with the Global Health Council. 2002. Making childbirth
maternal/neonatal health determinants of violence, safer through promoting evidence-based care.
the appropriate use of technology, abortion,
adolescence, sexually transmitted diseases, Abstract: Full text available at:
HIV/AIDS, the role of midwives, and the role of http://www.globalhealth.org/assets/publications/Ma
traditional birth attendants. kingChildbirthSafer.pdf
Fikree, F. F. 2002. “Time to focus child survival Gray, R. H., E. M. Ferraz, M. S. Amorim, and L. F.
programs on the newborn: assessment of levels de Melo. 1991. “Levels and determinants of
and causes of infant mortality in rural early neonatal mortality in Natal, northeastern
Pakistan,” Bull. World Health Organ., vol. 80, Brazil: results of a surveillance and case-control
pp. 271–276. study,” Int. J. Epidemiol., vol. 20, no. 2,
pp. 467–473.
Abstract: Population-based surveys were conducted
in selected clusters of Pakistan’s least developed Abstract: An institution-based surveillance and
provinces, Balochistan and North-West Frontier nested case-control study was conducted in Natal,
Province (NWFP), including the Federally Northeastern Brazil to estimate the level and
determinants of early neonatal mortality. The early
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
6
Greenwood, R., M. Samms-Vaughan, J. Golding, Ho, N. K. 1996. “Priorities in neonatal care in
and D. Ashley. 1994. “Past obstetric history developing countries,” Singapore Med. J.,
and risk of perinatal death in Jamaica,” vol. 37, no. 4, pp. 424–427.
Paediatr. Perinat. Epidemiol., vol. 8 Suppl 1,
Abstract: Lower perinatal and neonatal mortality
pp. 40–53.
have been achieved in the developed countries
Abstract: Singleton survivors born to multigravidae following advancement of neonatal care,
in the whole island of Jamaica in two months introduction of high technologies, and better
(September–October 1986) were compared with knowledge of pathophysiology of the newborn
singleton perinatal deaths occurring to infants. Other contributing factors are organized
multigravidae throughout the island in the delivery room care with skillful resuscitative
12-month period September 1986 to August 1987. techniques as well as risk identification and
Past obstetric history was obtained from the efficient transport of the sick infants including in
mothers using a structured questionnaire. Deaths utero transfer of the fetus, etc. It cannot be
were categorized using the Wigglesworth assumed that similar results can be attained in
classification. Logistic regression was used to developing countries where financial and human
compare current outcomes in women who had had resources are the problems. With limited resources,
at least one previous pregnancy. Antepartum fetal it is necessary to prioritize neonatal care in the
deaths with (1) outcome of last pregnancy; developing countries. It is essential to collect
(2) previous cesarean section; (3) previous minimum meaningful perinatal data to define the
stillbirth; and (4) increasing gravidity. In the problems of each individual country. This is crucial
presence of these factors maternal age ceased to be for monitoring, auditing, evaluation, and planning
statistically significant. Deaths from immaturity of perinatal health care of the country. The
were strongly associated with the past obstetric definition and terminology in perinatology should
history, with increased risks for pregnancies to also be uniform and standardized for comparative
mothers with a history of previous miscarriage, studies. Pediatricians should be well trained in
perinatal death and premature live births. In resuscitation and stabilization of the newborn
general, however, the higher the gravidity the lower infants. Resuscitation should begin in the delivery
the risk. In the presence of these factors, maternal room and a resuscitation team should be formed.
age showed no significant association. Intrapartum This is the best way to curtail complication and
asphyxia was also associated with the outcome of morbidity of asphyxiated births. Nosocomial
the last pregnancy, history of prior stillbirth or infections have been the leading cause of neonatal
neonatal death. First pregnancies were at deaths. It is of paramount importance to prevent
significantly higher risk than second pregnancies infections in the nursery. Staff working in the
(P<0.05). For perinatal deaths as a whole, and in nursery should pay attention to usage of sterilized
the presence of maternal age, the following were equipment, isolation of infected babies and aseptic
statistically significant independent factors: (1) the procedures. Pediatricians should avoid
outcome of the immediately preceding pregnancy indiscriminate use of antibiotics. Most important
(high risks associated with prior miscarriage, of all, hand-washing before examination of the
stillbirth and premature live births); (2) previous baby is mandatory and should be strictly adhered
cesarean section (increased risk); (3) previous to. Other simpler measures include warming
7
Liljestrand, J. 1999. “Reducing perinatal and surgical intervention, the average total cost of
maternal mortality in the world: the major hospitalization was Rs. 36,040 (U.S. $1,900) per
challenges,” Br. J. Obstet. Gynaecol., vol. 106, patient, with an average daily cost of Rs. 923 (U.S.
no. 9, pp. 877–880. $49). The longest hospital stay was six months, for
a child who had total colonic aganglionosis
Abstract: Effective reduction of perinatal and
associated with a short gut syndrome. There were
maternal mortality remains a major global
two deaths in this group. (2) Of the 21 premature
challenge. The main causes of neonatal deaths are
neonates admitted having Idiopathic Respiratory
asphyxia, birth trauma, infection, prematurity, and
Distress Syndrome (IRDS) during this period, the
malformation. However, there are several simple
total hospitalization cost per patient was
and noncostly measures that can avoid these
Rs. 23,260 (U.S. $788), with a daily cost of
problems. These are: 1) syphilis screening
Rs. 1,050 (U.S. $55). Eleven patients required
programs; 2) tetanus toxoid vaccination;
ventilatory support. There were 16 survivors.
3) immunizing women twice during their
Among both groups, 6% of all revenues generated
pregnancy; 4) nutritional supplementation; and
in the NICU were used to help families pay for the
5) prevention and treatment of severe anemia. Yet,
bills under a welfare scheme.
the most important intervention that is both
relatively simple and cost-effective can be Department of Surgery, Aga Khan University
implemented during pregnancy. On the other hand, Hospital, Karachi, Pakistan.
reducing maternal mortality poses as a much bigger
challenge. The primary concern in preventing
mortality lies in avoiding pregnancy, evading the Mohapatra, S. S. and R. K. Baag. 1982. “Customs
complications during pregnancy, or by controlling and beliefs on neonatal care in a tribal
the complications if ever they arise. Furthermore, community,” Indian Pediatr., vol. 19, no. 8,
the WHO stated that the presence of a skilled pp. 675–678.
attendant at birth is one of the most effective Abstract: One hundred and seventy tribal mothers
interventions in reducing maternal mortality. In of Dangaria Kandh Community were interrogated
general, perinatal and maternal mortality reduction to know their age-old customs and beliefs on
requires long-term efforts and strengthening of the neonatal care. The practices were again classified
health care systems. as beneficial, innocuous and harmful. Beneficial
practices like rooming in (100%), early
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
purchasing equipment and supplies, placing short- South Asia scores are especially low and East
term consultants in the unit as teachers, and Asia’s are especially high. To a considerable extent
bringing selected leaders to the United States for regions agree in the relative stress they give to each
brief fellowships. An evaluation at 18 months of the 14 components. Over the three-year period,
disclosed poor organization and leadership, average scores rose by about 10%. When
inconsistent clinical care, and unsatisfactory countries are divided into three groups by their
utilization and maintenance of facilities and maternal mortality levels, most of the 14
equipment. Therefore the strategy was revised to components distinguish the high from the medium
include long-term physician and nursing mortality countries; and about half of the
consultants, establishment of ties with HOPE components distinguish the medium from the low
Biomedical Engineering projects, and development mortality countries. This new Maternal and
of formal education programs. The unit was Neonatal program Effort Index (MNPI) appears to
transferred to the Chinese after four years and an yield useful measures for various dimensions of
evaluation one year after transfer revealed an program effort, and it relates sensibly to the
actively functioning independent NICU with output measure of maternal mortality, at least as it
evolving effective leadership, established is currently measured.
purchasing and preventive maintenance programs,
The Futures Group International, Glastonbury,
and continuing formal education activities.
Connecticut, USA. J.Ross@tfgi.com.
Unsatisfactory progress was found with the
development of a transport system, some
laboratory capabilities, adherence to admission and Save the Children. 2001. The state of the world’s
discharge policies, and various other administrative newborns 2001.
issues. Although the goal of establishing an
independent NICU was realized, perhaps the most Abstract: In the State of the World’s Newborns, we
lasting accomplishment was the establishment of a review the most recent data on the newborn,
facility and a format for development of a revealing the alarmingly poor health and quality of
10
health care for mothers and newborns in virtually with these complications to more specialized care
all impoverished countries. While there has been a settings could result in improved delivery
dramatic reduction in under-five mortality in the outcomes.
past two decades, there has been relatively little
Institute of Nutrition of Central America and
change in newborn mortality, even though proven,
Panama, Guatemala City, Guatemala.
cost-effective solutions exist to save many of these
young lives. Indeed, newborn deaths now
constitute over 40% of all deaths to children under Straughn, H. K., R. L. Goldenberg, J. E. Tolosa,
age five. Until recently, policymakers and program S. Daly, J. de Codes, M. R. Festin,
planners focused relatively little attention on this S. Limpongsanurak, P. Lumbiganon, V. K. Paul,
age group, concentrating instead on interventions A. Peedicayil, M. Purwar, J. C. Sabogal, and
that primarily benefit infants over one month of S. Shenoy. 2003. “Birthweight-specific neonatal
age. We now recognize, however, that additional mortality in developing countries and obstetric
gains in child survival will depend in large measure practices,” Int. J. Gynaecol. Obstet., vol. 80,
on saving newborn lives. no. 1, pp. 71–78.
Available at: Abstract: OBJECTIVES: To evaluate birthweight-
http://www.savethechildren.org/mothers/newborns_ specific neonatal mortality and perinatal
report.html interventions in major medical centers in developed
and developing countries. METHODS: A survey
was developed and electronically mailed to
Schieber, B., K. O’Rourke, C. Rodriguez, and
13 medical centers participating in the Global
A. Bartlett. 1994. “Risk factor analysis of peri-
Network for Perinatal and Reproductive Health
neonatal mortality in rural Guatemala,” Bull.
(GNPRH). The ability of a center to provide
Pan Am. Health Organ., vol. 28, no. 3,
requested data was assessed. The mortality rates
pp. 229–238.
and use of specific perinatal interventions in centers
Abstract: Peri-neonatal mortality is a serious in developing countries were compared with
health problem in Guatemala, especially in rural developed countries. RESULTS: Nine centers in
areas where most deliveries occur at home and are developing countries responded to the survey, and
overseen by traditional birth attendants (TBAs) three centers in developed countries were used for
who function in the role of midwives. The three comparison. Data collection was highly variable.
aims of the work reported here were to identify Most developing country centers were able to
important predictors of peri-neonatal mortality provide data by birthweight but not by gestational
within a rural area of Guatemala; to assess the age. The differences in mortality rates between
effects of traditional and modern health care developing and developed countries were more
providers on such mortality; and to find ways of pronounced at lower gestational ages and
identifying high-risk women who might benefit birthweights. A difference was found in perinatal
from transfer to a hospital or clinic. For these interventions between developing and developed
purposes a case-control study was conducted of countries. In the former, viability was generally
120 women in the rural department of considered 28 weeks, and the gestational age at
Quetzaltenango who had lost their babies from the which cesarean sections were usually performed for
11
Furthermore, incomplete and inconsistent data overcome, and the impact of the intervention can
collection complicates the evaluation of the factors be more rigorously evaluated. This paper reports
contributing to high neonatal mortality rates. the impact of perinatal audit in a rural African
health district between 1991 and 1995. A total of
21,112 consecutive births were studied: the average
Tinker, A. and E. Ransom. 2002. Healthy mothers number of deliveries increased by 31% from
and healthy newborns: the vital link. 325 to 424 per month. The PNMR (birthweight
Population Reference Bureau. > or = 1,000g) in 1991 was 27/1,000, increased to
Abstract: (Abstract taken from Acknowledgments 42/1,000 in 1992, and fell steadily to 26/1,000 in
and Conclusion) This brief is the first in the 1995 (40% reduction; p=0.002). The proportion of
“Policy Perspectives on Newborn Health” series, avoidable deaths fell from 19% in 1991 to zero in
produced through collaboration between the the second half of 1995 (p=0.0008). While factors
Population Reference Bureau and Save the associated with perinatal mortality are many,
Children’s Saving Newborn Lives initiative. Aimed complex, and interrelated, this report suggests that
at government decisionmakers and health care mortality can be reduced significantly in resource-
professionals, “Policy Perspectives on Newborn poor settings by improving quality of health care.
Health” will show how incorporating newborn Including the measurement of avoidable deaths in
care into existing safe motherhood and child perinatal audit allows the impact of interventions
survival programs can ensure newborn survival, as to be more rigorously assessed than by simple
well as contribute to improving women’s health measuring the PNMR.
and the well-being of future generations. Saving Centre for Epidemiological Research in South
Newborn Lives, launched with a generous Africa, Medical Research Council.
contribution from the Bill and Melinda Gates
Foundation, is a 15-year initiative to improve the
health and survival of newborns in the developing World Health Organization. 1996. Essential
world. newborn care.
Newborns are the most vulnerable members of
Abstract: Of 8.1 million infant deaths in 1993,
society. Preventing newborn deaths and improving
almost half (3.9 million, 48%) were neonatal
newborn health and survival go hand in hand with
deaths. While infant mortality has been decreasing
promoting safer motherhood. Decisionmakers can
steadily all over the world, changes in neonatal
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
13
2. Selected Maternal Health Aspects
with Direct Impact on Newborn
Health, Including Antenatal Care
and Prevention of Low Birthweight
General Aspects
Abebe, G. M. and A. Yohannis. 1996. “Birth AND CONCLUSIONS: Genetic abnormalities
interval and pregnancy outcome,” East Afr. cannot be prevented after conception, but many of
Med. J., vol. 73, no. 8, pp. 552–555. them, and a number of acquired conditions, can be
discovered by ultrasonographic and biochemical
Abstract: A cross-sectional study was conducted
diagnostics. The advisability of screening must be
from September to March 1993 at maternity ward
determined locally for each condition, based on
of Jimma Hospital to asses the pattern and
prevalence, treatment options and the legal
determinants of birth interval and the role of
requirements for abortion. Smoking, excessive
contraceptive in influencing the length of birth
alcohol intake, and severe undernutrition cause
interval. The information was collected by use of
fetal growth retardation. Interventions to reduce
pre-tested questionnaire from 415 mothers by three
maternal smoking have had limited success.
midwives trained for this purpose. The variables
Protein-energy supplementation only modestly
examined were: information on parity, use of
affects birthweight. Routine measurement of
contraceptive methods during the preceding birth
uterine height is a good predictor of severe growth
intervals, breastfeeding and some demographic
retardation and in rural settings of perinatal death.
variables such as age, martial status, education.
Preterm birth has been linked to ascending
Pregnancy outcome variables such as, live births,
infection and subsequent rupture of the
stillbirths, abortion and infant deaths. Slightly over
membranes. Attempts to eradicate local infections
75% of the study subjects were aged 20–29 years,
have shown some benefit but results are not
59% and 27% were para 2–3 and 4–5 respectively.
convincing yet. Cervical cerclage and betamimetic
In more than 81% of the subjects, the birth
drugs have little, if any, effect. Claims for reduction
interval was less than three years with a mean birth
of physical strain (standing >5 hours) at work
interval of 22.1 months. Approximately 2% used
should be supported. Tuberculosis in the mother
contraceptive when the birth interval was
should be discovered and treated. Malaria
12 months and less. Stillbirth and early neonatal
prophylaxis during pregnancy will protect the
deaths accounted for 3.2% and 6.9% respectively.
mother and possibly benefit the fetus. Adequate
Based on the findings, we underscore the
tetanus immunization of all mothers is a high
importance of birth spacing using the available
priority intervention in developing countries. In
family planning methods to promote safe
HIV-positive mothers, Zidovudine ante- and
motherhood and achieve better child survival.
perinatally will lower perinatal HIV transmission
Department of Obstetrics and Gynaecology, Jimma significantly. Risk scoring may help identify some
Institute of Health Sciences, Ethiopia. women for referral to higher level of care. Routine
ultrasonography does not improve the outcome of
pregnancy in terms of live births and morbidity,
Bergsjo, P. and J. Villar. 1997. “Scientific basis for but may influence mortality through discovery and
the content of routine antenatal care. II. Power abortion of fetuses with major malformations. One
to eliminate or alleviate adverse newborn vaginal examination during pregnancy is
outcomes; some special conditions and recommended but no repeat procedure unless
examinations,” Acta Obstet. Gynecol. Scand., medically indicated.
vol. 76, no. 1, pp. 15–25.
Abstract: BACKGROUND: There is uncertainty Bhardwaj, N., S. B. Hasan, and M. Zaheer. 1995.
concerning antenatal care as a tool to eliminate or “Maternal care receptivity and its relation to
alleviate adverse outcomes in the newborn. We perinatal and neonatal mortality. A rural
identified congenital conditions, intrauterine study,” Indian Pediatr., vol. 32, no. 4,
GENERAL ASPECTS
17
pregnant mothers at their door steps. During 25% of pregnancies were not registered even
follow-up, scores were allotted to each of the though the prenatal clinic was accessible and
services rendered and antenatal status of pregnant outreach was provided. <20% completed the
women. Depending on the score—MCR was recommended number of prenatal visits. 75–85%
classified as high (11 to 8), moderate (7 to 4) or visited at least once and sometimes more often.
poor (3 to 0). Perinatal and neonatal deaths were Screening for high risk must be done at the 1st
recorded and an inverse relationship between MCR visit. Women had strong feelings about the
and perinatal and mortalities was observed preference for a Dai during delivery and for place
(z=5.46, p<0.0001). Significantly, no perinatal or of delivery. Poor training of health workers was
neonatal deaths occurred in women with high reflected in the lack of adequate sanitation during
MCR. One of the most important cause of high the birthing process. Neonatal units were lacking
PNMR and neonatal mortality rate in developing and primary care absent. 10–14% of births were
countries is poor MCR, i.e., under utilization of preterm of which 50% occurred at 36 weeks.
even the existing maternal health services. The Multiple regression identified risk factors for fetal
main reasons for this under utilization appear to be and neonatal mortality and LBW as maternal age,
poverty, illiteracy, ignorance and lack of faith in preterm birth, maternal anemia, previous preterm
modern medicine. or LBW, birth interval, and previous fetal and
neonatal mortality. Recommendations are for
improving sanitation, hygiene, and water supplies,
Bhargava, S. K., K. K. Singh, and B. N. Saxena. promoting community awareness of the adverse
1991. “ICMR Task Force National effects of early marriage and close birth spacing,
Collaborative Study on Identification of High improving the delivery of health care, allocating
Risk Families, Mothers and Outcome of their health resources based on morality rates, using an
Off-springs with particular reference to the intersectoral approach for dealing with the
problem of maternal nutrition, low birth complex social and personal habits adversely
weight, perinatal and infant morbidity and affecting childbearing and seven other suggestions.
mortality in rural and urban slum communities. Existing services and their use are inadequate.
Summary, conclusions and recommendations,”
Indian Pediatr., vol. 28, no. 12,
pp. 1473–1480. Bloom, S. S., T. Lippeveld, and D. Wypij. 1999.
“Does antenatal care make a difference to safe
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
18
visits versus less—masked a large amount of Boller, C., K. Wyss, D. Mtasiwa, and M. Tanner.
variation in care received. Logistic regression 2003. “Quality and comparison of antenatal
analyses were conducted to examine the effect of care in public and private providers in the
antenatal care utilization on the likelihood of United Republic of Tanzania,” Bull. World
using safe delivery care, a factor known to Health Organ., vol. 81, no. 2, pp. 116–122.
decrease maternal mortality. After controlling for
Abstract: OBJECTIVE: To compare the quality of
relevant socio-demographic and maternity history
public and private first-tier antenatal care services
factors, women with a relatively high level of care
in Dar es Salaam, United Republic of Tanzania,
(at the 75th percentile of the score) had an
using defined criteria. METHODS: Structural
estimated odds of using trained assistance at
attributes of quality were assessed through a
delivery that was almost four times higher than
checklist, and process attributes, including
women with a low level of care (at the 25th
interpersonal and technical aspects, through
percentile of the score) (OR=3.97,
observation and exit interviews. A total of
95% CI: 1.96–8.10). Similar results were obtained
16 health care providers, and 166 women in the
for women delivering in a health facility versus at
public and 188 in the private sector, were selected
home. This strong positive association between
by systematic random sampling for inclusion in the
level of care obtained during pregnancy and the
study. Quality was measured against national
use of safe delivery care may help explain why
standards, and an overall score calculated for the
antenatal care could also be associated with
different aspects to permit comparison.
reduced maternal mortality.
FINDINGS: The results showed that both public
and private providers were reasonably good with
Boerma, J. T. and G. T. Bicego. 1992. “Preceding regard to the structural and interpersonal aspects
birth intervals and child survival: searching for of quality of care. However, both were poor when
pathways of influence,” Stud. Fam. Plann., it came to technical aspects of quality. For
vol. 23, no. 4, pp. 243–256. example, guidelines for dispensing prophylactic
drugs against anemia or malaria were not
Abstract: The importance of the length of respected, and diagnostic examinations for the
preceding birth intervals for the survival chances of assessment of gestation, anemia, malaria or urine
young children has been established, but the debate infection were frequently not performed. In all
concerning the causal biomedical or behavioral aspects, private providers were significantly better
mechanisms continues. This article uses data from than public ones. CONCLUSION: Approaches to
17 Demographic and Health Surveys to investigate improving quality of care should emerge
the effect of birth intervals on child mortality: progressively as a result of regular quality
Anthropometry of children, recent morbidity of assessments. Changes should be introduced using
children, and use of health services are examined in an incremental approach addressing few
addition to child survival data for children born in improvements at a time, while ensuring
the five years before the survey. Various participation in, and ownership of, every aspect of
methodological approaches are used to investigate the strategy by health personnel, health planners
the relative importance of the postulated and managers and also the community.
mechanisms linking birth intervals and child
survival. Short preceding birth intervals are
associated with increased mortality risks in the Bouckaert, A. 2000. “Smoking during pregnancy:
neonatal period and at 1–6 months of age, and, to foetal growth retardation and other risks for the
a much lesser extent, at 7–23 months of age. The newborn,” Stat. Med., vol. 19, no. 2,
effects of short birth intervals on nutritional status pp. 239–254.
are rather moderate, and there is a weak
Abstract: In spite of the well-known effect of
relationship with lower attendance at prenatal care
tobacco on embryo growth retardation, of the
services. No consistent relationship exists between
higher perinatal mortality of the offspring of
the length of birth intervals and other health status
GENERAL ASPECTS
19
score <7 at the 10th minute of life) as endpoints Carroli, G., J. Villar, G. Piaggio, D. Khan-Neelofur,
rather than perinatal or fetal mortality. A stochastic M. Gulmezoglu, M. Mugford, P. Lumbiganon,
model constructed to account for cause-effect U. Farnot, and P. Bersgjo. 2001. “WHO
relations demonstrated that tobacco influences systematic review of randomized controlled
weight and mortality by independent pathways. trials of routine antenatal care,” Lancet,
Furthermore, this model shed some light on the vol. 357, no. 9268, pp. 1565–1570.
non-tobacco determinants of small birthweight and
Abstract: BACKGROUND: There is a lack of
neonatal morbidity. The method undertaken, based
strong evidence on the effectiveness of the content,
on the use of latent variables, had the advantage of
frequency, and timing of visits in standard
analyzing the prevalence, consequences and
antenatal-care programs. We undertook a
interactions of some risk factors without
systematic review of randomized trials assessing
identifying them.
the effectiveness of different models of antenatal
care. The main hypothesis was that a model with a
CARE. 2002. Maternal and newborn care: a lower number of antenatal visits, with or without
reference manual for program managers. goal-oriented components, would be as effective as
the standard antenatal-care model in terms of
Abstract: A comprehensive, technical manual, this clinical outcomes, perceived satisfaction, and costs.
publication summarizes recent literature and METHODS: The interventions compared were the
lessons learned from program implementation to provision of a lower number of antenatal visits
reduce maternal and newborn mortality. It reviews (new model) and a standard antenatal-visits
the health and non-health causes of mother and program. The selected outcomes were pre-
infant deaths and morbidity, and provides guidance eclampsia, urinary-tract infection, postpartum
for designing, monitoring, and evaluating a anemia, maternal mortality, low birthweight, and
maternal health program. The manual features perinatal mortality. We also selected measures of
information on key interventions and best women’s satisfaction with care and cost-
practices, compiled from 10 years of the global effectiveness. This review drew on the search
Safe Motherhood Initiative, along with a series of strategy developed for the Cochrane Pregnancy
case examples of existing programs working to and Childbirth Group of the Cochrane
promote maternal and newborn survival; these Collaboration. FINDINGS: Seven eligible
include initiatives to improve obstetric services and randomized controlled trials were identified.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
20
CATALYST Consortium. 2002. Report on 2nd IUGR. Women having had poor content showed a
champions meeting on birth spacing. PD OR of 1.76 (95% CI: 1.33–2.34). An
important reduction in the incidence of births with
Abstract: Information available via email at:
IUGR and PD could be expected if women could
info@rhcatalyst.org
attend an adequate number of antenatal visits
Chandramohan, D., F. Cutts, and P. Millard. 1995. (11% and 9% reductions, respectively). Eighteen
“The effect of stay in a maternity waiting home percent of the PD births would probably be
on perinatal mortality in rural Zimbabwe,” J. prevented if antenatal care could include at least
Trop. Med. Hyg., vol. 98, no. 4, pp. 261–267. six procedures: blood pressure, height and weight,
urine and blood samples, and pelvic examination.
Abstract: A hospital-based cohort study was
carried out in a district hospital in Zimbabwe to
evaluate the effect of a maternity waiting home on Doctor, B. A., M. A. O’Riordan, H. L. Kirchner,
perinatal mortality. Information on antenatal risk D. Shah, and M. Hack. 2001. “Perinatal
factors, use of antenatal care, access to the hospital correlates and neonatal outcomes of small for
and stage of labor on arrival was collected for each gestational age infants born at term gestation,”
woman delivering at the hospital during the period Am. J. Obstet. Gynecol., vol. 185, no. 3,
1989–1991 (n=6,438). Women who stayed in the pp. 652–659.
maternity waiting home had a lower risk of
Abstract: OBJECTIVE: We sought to examine the
perinatal death compared to women who came
current perinatal correlates and neonatal morbidity
directly from home to the hospital during labor.
associated with intrauterine growth failure among
The crude relative risk of perinatal death for the
neonates born at term gestation. STUDY DESIGN:
women coming from home was 1.7
We compared 372 small for gestational age (SGA,
(95% confidence interval (CI): 1.1–2.6; P<0.05).
birthweight <10th percentile) infants born at term
After adjusting for the effect of potential
gestation to 372 appropriate for gestational age
confounding variables, the relative risk decreased
controls (AGA, birthweight 10th to 90th
to 1.5 (95% CI: 0.95–2.5, P=0.07). However, when
percentile) matched by sex, race, and gestational
the analysis was restricted to women with
age within two weeks. RESULTS: Compared with
antenatal risk factors there was a significant
AGA controls, significant (P<.05) maternal risk
50% reduction in the risk of perinatal death for the
factors for SGA status included single marital
women who stayed at the maternity waiting home
status (59% versus 53%), lower prepregnancy
compared to women who came from home during
weight (144 +/– 41 lbs versus 153 +/– 40 lbs),
labor (adjusted relative risk 1.9; 95% CI: 1.1–3.4;
lower weight gain during pregnancy (29 +/– 15 lbs
P<0.05). The use of maternity waiting homes has
versus 33 +/– 15 lbs), smoking (25% versus 17%),
the potential to reduce perinatal mortality in rural
hypertension (14% versus 7%), and multiple
areas with low geographic access to hospitals and
gestation (9% versus 2%). Mothers of SGA infants
merits further evaluation.
were more likely to undergo multiple (> or = 3)
antenatal ultrasound evaluations (19% versus 7%),
Coria-soto, I. L., J. L. Bobadilla, and F. Notzon. biophysical profile monitoring (11% versus 4%),
1996. “The effectiveness of antenatal care in and oxytocin delivery induction (28% versus 16%)
preventing intrauterine growth retardation and (P<.05). Pediatrician attendance was more common
low birth weight due to preterm delivery,” Int. among SGA deliveries (50% versus 37%, P<.05).
J. Qual. Health Care, vol. 8, no. 1, pp. 13–20. SGA infants had significantly higher rates of
hypothermia (18% versus 6%) and symptomatic
Abstract: A case-control study was conducted to hypoglycemia (5% versus 1%). These neonatal
assess the effectiveness of antenatal care in problems remained significant even when medical
preventing intrauterine growth retardation (IUGR) or pathologic causes of intrauterine growth failure,
and low birthweight due to preterm delivery (PD), including pregnancy hypertension, multiple
using data from 1,837 births which took place in gestation, and congenital malformations, were
GENERAL ASPECTS
25 hospitals in Mexico City during 1984. Women excluded. CONCLUSION: Despite higher rates of
with an inadequate number of visits for gestational pregnancy complications among mothers of SGA
age had 63% greater odds of IUGR infants, the rates of neonatal adverse outcomes are
(95% CI: 1.01–2.65) and 51% greater odds of PD low. However, SGA infants remain at risk for
(95% CI: 1.02–2.23) than women with an hypothermia and hypoglycemia and require careful
adequate number. The content of antenatal visits neonatal surveillance.
showed no independent effect on the prevention of
21
Drazancic, A. 2001. “Antenatal care in developing birthweight. When maternal postpartum body
countries. What should be done?” J. Perinat. weight was introduced into the logistic model, the
Med., vol. 29, no. 3, pp. 188–198. risk of intrauterine growth retardation decreased
slightly to 1.25 and was no longer significant
Abstract: Development of antenatal care from the
(95% CI: 0.91–1.72). Short interpregnancy
beginning of the 20th century and its relation to
intervals (six months or less) were more frequently
perinatal mortality in developed countries is
observed in women with postpartum body weight
presented. The role of socioeconomic factors, new
of less than 45kg (31.1%) than in women weighing
diagnostic and therapeutic procedures, extended
50kg or more (18.9%), which might suggest that
indications for cesarean section and of neonatal
the effect of short intervals on the risk of
intensive care is also stressed. In the West- and
intrauterine growth retardation is mediated
Middle-European countries by the introduction of
through maternal nutritional status. No association
antenatal care the perinatal mortality (PNM) rate
was found between birth-to-conception intervals
decreased from about 60.0 per 1,000 in the years
and preterm delivery.
1920–1930 to about 40.0 per 1,000 in 1950s.
Further decrease to about 25.0 per 1,000 in the
1970s was conditioned by an increase of number Fuentes-Afflick, E. and N. A. Hessol. 2000.
of antenatal visits and by extended indications for “Interpregnancy interval and the risk of
cesarean section. New technologies (amnioscopy, premature infants,” Obstet. Gynecol., vol. 95,
pH.metry, cardiotocography and ultrasound no. 3, pp. 383–390.
examinations) decreased the PNM rate to about
13.0 per 1,000 in the year 1980. Regional Abstract: OBJECTIVE: Interpregnancy intervals are
organization with neonatal intensive care units associated with the risk of low birthweight (LBW)
decreased PNM rate to low values of 5.0–9.0 per infants, but the association between interpregnancy
1,000. The echo of the number of antenatal visits interval and prematurity is unknown. Our objective
to PNM rate is illustrated on 36,855 deliveries at was to determine whether interpregnancy intervals
the University Clinic in Zagreb. In developing were associated with the risk of premature infants
countries maternal and perinatal mortality is very and to define the degree of risk according to
high. The reason for that is a bad socioeconomic interpregnancy interval. METHODS: We analyzed
background and a lack of organized antenatal and 289,842 singleton infants born to parous Mexican-
perinatal health care system. The policy to decrease origin Hispanic and non-Hispanic white women in
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
maternal and perinatal mortality is presented: the the United States who resided in the same county
improvement of antenatal booking and of the and delivered between January 1, 1991 and
number of prenatal visits of pregnant women; their September 30, 1991. Interpregnancy interval was
childbearing under professional assistance. The defined as the number of months between the
organizing of maternity health care should be previous live birth and conception of the index
different from country to country, from region to pregnancy. Multivariate logistic regression analysis
region, respectively. was used to estimate odds ratios and
95% confidence intervals for the risk of
interpregnancy interval on very premature
Ferraz, E. M., R. H. Gray, P. L. Fleming, and T. M. (23–32 weeks), moderately premature
Maia. 1988. “Interpregnancy interval and low (33–37 weeks), and term gestation (38–42 weeks).
birth weight: findings from a case-control RESULTS: Nearly 37% of women had
study,” Am. J. Epidemiol., vol. 128, no. 5, pp. interpregnancy intervals less than 18 months,
1111–1116. 45.5% of women had intervals of 18–59 months,
and 17.6% of women had intervals over
Abstract: In a case-control study in Natal,
59 months. After adjusting for confounding
northeast Brazil, conducted between September
variables, women with intervals less than
1984 and February 1986, 303 cases of intrauterine
18 months were 14–47% more likely to have very
growth retardation and 282 cases of preterm
premature and moderately premature infants than
delivery were compared with 1,710 normal
women with intervals of 18–59 months. Women
controls to ascertain the effects of the preceding
with intervals over 59 months were 12–45% more
birth-to-conception interval on pregnancy outcome.
likely to have very premature and moderately
The risk of intrauterine growth retardation
premature infants than women with intervals of
associated with interpregnancy intervals of six
18–59 months. CONCLUSION: Women with
months or less was 1.38 (95% confidence interval
interpregnancy intervals from 18–59 months had
(CI): 1.02–1.86) after adjustment for maternal age,
the lowest risk of very premature and moderately
education, smoking, and prior fetal loss or low
22
premature infants. Further study is needed to define Nations Population Fund (UNFPA), World Health
the mechanisms through which interpregnancy Organization (WHO), International Center for
interval influences pregnancy outcome. Research on Women (ICRW), JHPIEGO, Pan
American Health Organization (PAHO), U.S.
Agency for International Development (USAID),
Gay, J., K. Hardee, N. Judice, K. Agarwal, K. and others. Forthcoming modules in the series will
Fleming, A. Hairston, B. Walker, and M. Wood. focus on addressing STIs/HIV/AIDS and reducing
2003. A policy and program guide to the unintended pregnancies.
evidence on family planning, safe motherhood,
and STI/HIV/AIDS interventions: module Available at:
one—safe motherhood. The Policy Project. http://www.policyproject.com/pubs/generalreport/S
M_WhatWorksps2.pdf
Abstract: Worldwide, about 500,000 women and
girls die of complications related to pregnancy and
childbirth each year; and over 99% of these deaths Gerein, N., S. Mayhew, and M. Lubben. 2003. “A
occur in developing countries. The tragedy—and framework for a new approach to antenatal
opportunity—is that most maternal deaths could care,” Int. J. Gynaecol. Obstet., vol. 80, no. 2,
be prevented with cost-effective health care pp. 175–182.
services. Facing a range of competing priorities and
Abstract: A framework for a new approach to
limited resources, policymakers and program
antenatal care (ANC) is presented to improve
planners are in need of concise information on
maternal health. Based on evaluations of ANC,
programs that are both effective and feasible.
safe motherhood programs, gender and social
The POLICY Project is pleased to have the
theory, it suggests that managers should draw upon
opportunity to make a significant contribution to
existing family and community support systems,
the maternal health field with the launch of a new
and develop partnerships beyond the health service.
resource that documents safe motherhood
Policy and program changes are required in:
interventions that work. This publication-the first
professional mandates for ANC providers,
in a series entitled “What Works: A Policy and
organization of ANC services, service protocols,
Program Guide to the Evidence on Family
training programs, policy towards TBAs, referral
Planning, Safe Motherhood, and STI/HIV/AIDS
care, and service support systems.
Interventions”—presents a comprehensive review
of the interventions (with supporting evidence) that
have been shown to enhance maternal health in Global Health Council. 2002. Making childbirth
developing countries. safer through promoting evidence-based care.
Importantly, this document helps public health
officials and decision makers answer the question Abstract: Towards an evidence-based approach to
“What should we do?” when trying to figure out decision making; reducing maternal mortality
how to improve maternal health. It is also a tool to through evidence-based treatment of eclampsia;
help maternal health advocates demonstrate that reducing postpartum hemorrhage: routine use of
safe motherhood programs save lives, benefit active management of the third stage of labor; the
societies and communities, and are effective and WHO reproductive health library; better births
feasible, even in resource-constrained settings. initiative: a program for action in middle- and low-
The Safe Motherhood Module brings together income countries; using evidence to save the lives
the best available evidence on a range of of mothers.
interventions and packages it in one convenient Available at:
source, covering topics such as Labor and Delivery, http://www.globalhealth.org/assets/publications/Ma
Postnatal Care, Care During Pregnancy, Pre- kingChildbirthSafer.pdf
pregnancy Care, and Policy and Program Issues. It
also provides guidance on programs that have not
been shown to work, programs that should be Hobel, C. and J. Culhane. 2003. “Role of
GENERAL ASPECTS
avoided, and programs for which more evidence is psychosocial and nutritional stress on poor
needed. Additional sections provide a summary of pregnancy outcome,” J. Nutr., vol. 133, no. 5
safe motherhood interventions and present Suppl 2, pp. 1709S–1717S.
resources for program designers.
Abstract: Epidemiological evidence suggests that
The Safe Motherhood Module has been
maternal psychosocial stress, strenuous physical
reviewed by some of the world’s leading maternal
activity and fasting are independent risk factors for
health experts, including those from the United
preterm birth and low birthweight. Data from
23
clinical studies consistently demonstrate that Khan, N. and M. Jamal. 2003. “Maternal risk
women in preterm labor have significantly elevated factors associated with low birth weight,” J.
levels of corticotropin-releasing hormone compared Coll. Physicians Surg. Pak., vol. 13, no. 1,
with age-matched control subjects. Because pp. 25–28.
production of corticotropin-releasing hormone
Abstract: OBJECTIVE: To determine the
appears to be stress sensitive, this neuropeptide
association of socio-demographic, maternal,
may play a critical role in the physiological
medical and obstetric risk factors with low
mediation among stressful experiences, work stress
birthweight. DESIGN: A case-control study.
and fasting and risk of preterm birth. In addition
PLACE AND DURATION OF STUDY: This study
to the direct effect of elevated corticotropin-
was carried out in the department of Neonatology,
releasing hormone on the initiation of labor, it may
Children Hospital and Mother and Child Health
have an immunomodulatory effect such that
Care Centre, Pakistan Institute of Medical Sciences,
women with high levels of corticotropin-releasing
Islamabad during August–September 2001.
hormone may be more susceptible to infection or
SUBJECTS AND METHODS: One hundred and
the pathological consequences of infection. We
ninety consecutive low birthweight (<2.5kg) live
review the epidemiological data linking maternal
born babies were enrolled cases against
stress, physical stain and fasting to preterm birth
760 consecutive normal birthweight (>2.5kg)
and low birthweight and review the plausible
babies as controls. Informations regarding
biological pathways through which these exposures
maternal, biosocial, medical and obstetric
may increase risk of preterm birth. The timing of
complications during pregnancy were recorded on
these exposures is considered important. Future
a pre-tested proforma. Data analysis was done
research and clinical programs addressing these
through logistic regression model in SPSS10 and
exposures must consider assessments and
results were interpreted in terms of odds ratio and
interventions before pregnancy.
p-values. RESULTS: The mean weight of cases was
2.08kg as compared to 3.1 in controls. Forty-six
Journal of Perinatology 2 A.D., Perinatal and percent of cases were preterm. The factors like
neonatal health interventions research: a maternal malnutrition, young age of the mothers,
supplement to the Journal of Perinatology. poverty, close birth spacing, hypertension and
antenatal per vaginum (p/v) bleeding during
Abstract: This supplement to the Journal of pregnancy have independent effect in causing low
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
24
associated with < or = 12-month interpregnancy Abstract: This paper provides an overview of the
intervals was the lowest among non-Hispanic occurrence, etiology and temporal trends of
whites (18.5%, 95% confidence interval (CI): adverse pregnancy outcomes. Disparities between
18.5–18.5) and the highest among Native developed and developing countries are highlighted
Americans (29.7%, 95% CI: 29.2–30.2). As for maternal mortality, infant mortality, stillbirth
compared with mothers with >12-month intervals, and low birthweight. The higher rate of low
mothers with <6-month intervals had an birthweight in developing countries is primarily
approximately 50% to 80% increased risk of very due to intrauterine growth restriction rather than
low (<1.5kg) birthweight delivery and a 30% to preterm birth. Much of the excess intrauterine
90% increased risk of very preterm (<32 weeks) growth restriction is caused by short maternal
delivery. Logistic regression analyses showed that stature, low prepregnancy body mass index and
the adverse effects of short intervals were reduced low gestational weight gain (due to low energy
by about 10% but remained for the most part intake). No important contribution has been
significant after controlling for potential established for micronutrient intake, nor have
confounding by maternal age, education, parity, different fetal growth trajectories been
marital status, prenatal care, smoking, and demonstrated to reflect the timing of exposure to
previous preterm delivery. nutritional or other etiologic factors. Infant
mortality has declined substantially over time both
in developed and developing countries despite no
Klerman, L. V., S. P. Cliver, and R. L. Goldenberg. decline (and even an increase) in low birthweight.
1998. “The impact of short interpregnancy Several developed countries have reported a
intervals on pregnancy outcomes in a low- temporal increase in fetal growth in infants born at
income population,” Am. J. Public Health, term, a reduction in stillbirth rates and prevention
vol. 88, no. 8, pp. 1182–1185. of neural tube defects. More progress is required,
Abstract: OBJECTIVES: The objective of this however, in understanding the etiology and
study was to determine whether the length of the prevention of preterm birth.
interval between pregnancies was associated with
either preterm birth or intrauterine growth
Kramer, M. S. 2000. “Invited commentary:
retardation in a low-income, largely Black
association between restricted fetal growth and
population. METHODS: The study population
adult chronic disease: is it causal? Is it
consisted of 4,400 women who had received
important?” Am. J. Epidemiol., vol. 152, no. 7,
prenatal care in county clinics and had two
pp. 605–608.
consecutive singleton births between 1980 and
1990. RESULTS: Interpregnancy intervals were Abstract: Concerns about confounding by lifestyle
positively associated with age and negatively factors and for the mechanism underlying the fetal
associated with the trimester in which care was growth restriction, statistical adjustments for adult
initiated in the second pregnancy. Whites had body size, and conflicting evidence from natural
shorter intervals than non-whites. The percentage experiments raise questions about whether such an
of preterm births increased as the length of the association is truly causal. Moreover, even if the
interpregnancy interval decreased, but only for association is causal, the evidence of period versus
women who had not had a previous preterm birth. birth cohort effects and of geographic and
The association between interval and preterm temporal trends suggests that the public health
birth was maintained when other factors importance of such an association is likely to be
associated with preterm birth were controlled. small, consistent with the small effect on blood
There was no significant relationship between pressure reported by Leon et al. Future
intrauterine growth retardation and epidemiologic studies should devise critical tests of
interpregnancy interval. CONCLUSIONS: Women, the fetal programming hypothesis rather than
particularly those who are poor and young, should merely replicate its predicted associations. More
be advised of the potential harm to their infants of basic scientific investigation should also be
GENERAL ASPECTS
25
Kramer, M. S. 1998. “Socioeconomic determinants racial origin, nutrition, low pre-pregnancy weight,
of intrauterine growth retardation,” Eur. J. short maternal stature, and malaria. Pre-pregnancy
Clin. Nutr., vol. 52 Suppl 1, pp. S29–S32. weight, prior premature birth or miscarriage,
diethylstilbestrol exposure and smoking were major
Abstract: This paper reviews the evidence bearing
determinants of gestational duration, but the
on socioeconomic determinants of intrauterine
majority of prematurity was unexplained in both
growth retardation (IUGR). The primary focus is
developed and developing countries. There is a
on those factors with a quantitatively important
need for future research on the effect of maternal
impact from a public health perspective, as
work, prenatal care, and certain vitamin and
indicated by their large etiologic fraction
mineral deficiencies on intrauterine growth, and
(population attributable risk). In developed
the effect of genital tract infection, prenatal care,
countries in which a sizeable proportion of women
maternal employment, stress and anxiety on
smoke during pregnancy, cigarette smoking is
prematurity.
associated with the largest etiologic fraction (by
far), followed by low gestational weight gain
(primarily due to low energy intake) and low Kwast, B. E. 1995. “Building a community-based
prepregnancy body mass index (BMI). In maternity program,” Int. J. Gynaecol. Obstet.,
developing countries where undernutrition is vol. 48 Suppl, pp. S67–S82.
prevalent and pregnant women do not smoke, low
maternal weight gain and BMI assume even greater Abstract: The MotherCare Project has as its goal
importance, as does short maternal stature. A the reduction of maternal and neonatal mortality
major section of the paper concerns the large and related morbidities, and the promotion of the
within-country socioeconomic disparities in IUGR health of women and newborns. To achieve these
and the possible mechanisms underlying these goals, maternal and family planning programs
disparities. In developed countries, differences in were strengthened in both rural and urban settings
cigarette smoking explain a large part of the through three intervention strategies—policy
disparity; low weight gain and short stature may reform, affecting behaviors and improving
also be important mediators in some settings. services. The fundamental premise in each project
Future etiologic studies should assess a wide scope was to strengthen the weakest part of the
of potential determinants and will require large maternity care pyramid, ensuring linkages among
sample sizes to control for their mutually all levels of service—from community through to
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
26
by traditional birth attendants (TBAs) to the detection of symptomless complications such as
hospital and reduced perinatal mortality. hypertension and deviation in fetal growth, as well
as giving psychosocial support and health
education. In a Swedish state-of-the-art conference
Langer, A., J. Villar, M. Romero, G. Nigenda, G. in May 1990, the scientific basis of this routine
Piaggio, M. Al Osimi, G. Rojas, M. Al Osimi, J. program was critically evaluated. It was clearly
Belizan, U. Farnot, Y. Al Mazrou, G. Carroli, demonstrated that the scientific evidence to support
H. Ba’aqeel, P. Lumbiganon, A. Pinol, P. present timing and contents of routine visits is
Bergsjo, L. Bakketeig, and J. Garcia. 2002. unsatisfactory, and that there is a great need for
“Are women and providers satisfied with evaluation both of single diagnostic procedures and
antenatal care? Views on a standard and a intervention and of programs of antenatal care.
simplified, evidence-based model of care in four Evaluations of antenatal care should consider not
developing countries,” BMC. Womens Health, only pregnancy outcome but also patient
vol. 2, no. 1, p. 7. satisfaction and cost-benefit analysis. Long-term
Abstract: BACKGROUND: This study assessed follow-up studies are urgently needed, not only of
women and providers’ satisfaction with a new the effects of complications but also of antenatal
evidence-based antenatal care (ANC) model within diagnosis and interventions.
the WHO randomized trial conducted in four
developing countries. The WHO study was a
MacArthur, C., J. R. Newton, and E. G. Knox.
randomized controlled trial that compared a new
1987. “Effect of anti-smoking health education
ANC model with the standard type offered in each
on infant size at birth: a randomized controlled
country. The new model of ANC emphasized
trial,” Br. J. Obstet. Gynaecol., vol. 94, no. 4,
actions known to be effective in improving
pp. 295–300.
maternal or neonatal health, excluded other
interventions that have not proved to be beneficial, Abstract: The effects of anti-smoking health
and improved the information component, education during pregnancy on smoking behavior
especially alerting pregnant women to potential and the subsequent infant’s size at birth were
health problems and instructing them on investigated in a controlled trial. It was found that
appropriate responses. These activities were the planned educational intervention was
distributed within four antenatal care visits for incompletely carried out and was given more
women that did not need any further assessment. effectively to primigravidae in whom subsequent
Methods Satisfaction was measured through a reduction of smoking was more evident. The effects
standardized questionnaire administered to a of educative intervention on size at birth were
random sample of 1,600 pregnant women and therefore analyzed for first and later pregnancies
another to all antenatal care providers. RESULTS: separately. The differences in birthweight and
Most women in both arms expressed satisfaction length between the intervention and control groups
with ANC. More women in the intervention arm were concentrated almost entirely among the first
were satisfied with information on labor, delivery, born infants who were 68g heavier and 0.75cm
family planning, pregnancy complications and longer in the intervention group than the first born
emergency procedures. More providers in the infants in the control group.
experimental clinics were worried about visit
spacing, but more satisfied with the time spent and
information provided. CONCLUSION: Women Madi, B. C., J. Sandall, R. Bennett, and C.
and providers accepted the new ANC model MacLeod. 1999. “Effects of female relative
generally. The safety of fewer visits for women support in labor: a randomized controlled
without complications with longer spacing would trial,” Birth, vol. 26, no. 1, pp. 4–8.
have to be reinforced, if such model is to be Abstract: BACKGROUND: This study was a
introduced into routine practice. randomized controlled trial of primigravidas in
Botswana to determine the effectiveness of the
GENERAL ASPECTS
27
Significantly more mothers in the experimental Abstract: This paper contains a set of rapid
group had a spontaneous vaginal delivery (91% vs. assessment tools to analyze existing maternal and
71%), less intrapartum analgesia (53% vs. 73%), peri/neonatal health status at both the national and
less oxytocin (13% vs. 30%), fewer amniotomies community levels. Each tool covers both qualitative
to augment labor (30% vs. 54%), fewer vacuum and quantitative indicators, and all have been used
extractions (4% vs. 16%), and fewer cesarean in the first phase of the MotherCare Project. The
sections (6% vs. 13%) than in the control group. first country-level tool is designed to assess safe
These differences were all significant at p<0.05. motherhood in general by gathering data on health
Epidural analgesia was not used in the hospital at policies and coverage of services, key population
the time of the study. The only analgesics used and fertility factors, rates of maternal mortality
were intramuscular pethidine or hyoscine and morbidity, and women’s social and economic
N-butylbromide (Buscopan). CONCLUSIONS: The status. The second country-level tool, which can
presence in labor of a female relative was shown to also be used at the community level, contains a set
be associated with fewer interventions and a higher of specific questions to determine the status of
frequency of normal delivery compared with the maternal and perinatal health. Community-level
outcomes of those without family member support. assessment tools focus on measuring maternal and
The presence of a female relative as a labor peri/neonatal health status through methods that
companion is a low-cost, preventative intervention include case reviews, surveys, and participatory
that is consistent with the traditional cultural group assessment. Each tool includes suggestions
practices in Botswana. In the light of this and for its use, along with advice on gathering or
previous studies, all women giving birth in a estimating data that may be hard to find (e.g.,
hospital should be offered the choice of a female national rates of maternal mortality.)
relative as a companion to give support during
ORDERING INFORMATION: Document can be
labor.
ordered free of charge, with a limit of 15 copies,
via mail or email to:
Marston, C. and J. Cleland. 2003, “Do unintended
John Snow, Inc./MotherCare
pregnancies carried to term lead to adverse
1616 North Fort Myer Drive 11th Floor
outcomes for mother and child? An assessment
Arlington, VA 22209, USA
in five developing countries,” Popul. Stud.
Email: mothercare_project@jsi.com
(Camb.), vol. 57, no. 1, pp. 77–93.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
28
researchers in determining and operationalizing provider of ANC. There was a large variation in
their questions and selecting research the actual use of screening and laboratory tests and
methodologies; module topics include prevention interventions that should be offered to all women
issues and normal care of mothers and infants, according to Cochrane PCD criteria: some of these
community responses to complications, and are simply not available in a site; others are
communication. Two final chapters describe how available, but only a fraction of women attending
to analyze data collected, and how to turn the the clinics are receiving them. The participating
findings into policy action. An appendix lists sites all purport to follow the traditional
publications and Internet resources for quantitative “Western” schedule for ANC, but in three sites we
and qualitative research. found that a high percentage of women initiate
their ANC after the first trimester, and therefore do
ORDERING INFORMATION: Document can be
not have either the recommended minimum
found online at:
number of visits during pregnancy or the minimum
http://www.jsi.com/intl/mothercare/home.htm
first trimester evaluation. It is concluded that the
Or mail or email order and request to: variability and heterogeneity of ANC services
John Snow, Inc. provided in the four study sites are disturbing to
MotherCare the profession and cast doubts on the rationale of
1616 North Fort Myer Drive, 11th Floor routine ANC.
Arlington, VA 22209, USA
Email: mothercare_project@jsi.com
Prual, A., L. De Bernis, and D. O. El. 2002.
“Potential role of prenatal care in reducing
Piaggio, G., H. Ba’aqeel, P. Bergsjo, G. Carroli, U. maternal and perinatal mortality in sub-Saharan
Farnot, P. Lumbiganon, A. Pinol, and J. Villar. Africa,” J. Gynecol. Obstet. Biol. Reprod.
1998. “The practice of antenatal care: (Paris), vol. 31, no. 1, pp. 90–99.
comparing four study sites in different parts of
Abstract: Prenatal care has been implemented in
the world participating in the WHO Antenatal
developing countries according to the same mode
Care Randomized Controlled Trial,” Paediatr.
as applied in industrialized countries without
Perinat. Epidemiol., vol. 12 Suppl 2,
considering its real effectiveness in reducing
pp. 116–141.
maternal and neonatal mortality. Several recent
Abstract: In the preparation of a randomized studies suggest that the goals should be revisited in
controlled trial to evaluate a new program of order to implement a program of prenatal care
antenatal care (ANC) in different parts of the based on real scientific evidence. Based on the
world, we conducted a baseline survey of the ANC current literature, we propose a potentially
procedures in all 53 clinics participating in the effective content for prenatal care adapted to the
trial. There were two components of this survey: context of developing countries. Four antenatal
(1) description of clinic characteristics and services consultations would be enough if appropriately
offered: the staff of each clinic was interviewed and timed at 12, 26, 32 and 36 weeks pregnancy. The
direct observation was made by field supervisors, purpose of these consultations would be: 1) to
and (2) the actual use of services by pregnant screen for three major risk factors, which, when
women attending these clinics: we reviewed a recognized, lead to specific action: uterine, scare,
random sample of 2,913 clinical histories. The malpresentation, premature rupture of the
clinical units surveyed were offering most of the membranes; 2) to prevent and/or detect (and treat)
activities, screening, laboratory tests and specific complications of pregnancy: hypertension,
interventions recommended as effective according infection (malaria, venereal disease, HIV, tetanus,
to the Cochrane Pregnancy and Childbirth urinary tract infection); anemia and trace element
Database (PCD), although some of these were not deficiencies, gestational diabetes mellitus; 3) to
available in some sites. On the other hand, some provide counseling, support and information for
tests and interventions that are considered not pregnant women and their families (including the
GENERAL ASPECTS
effective according to these criteria are reportedly partner) concerning: severe signs and symptoms of
offered. There was a difference across sites in the pregnancy and delivery, community organization of
availability and offer to low-risk women of vaginal emergency transfer, delivery planning. These
examination, evaluation of pelvic size, dental potentially effective actions can only have a real
examination, external version for breech public health impact if implemented within an
presentation and formal risk score classification, organized maternal health system with a functional
and a notable difference in the type of principal network of delivery units, if truly quality care is
29
given, and if the relationships between health care were investigated. Newborn infants, from women
providers and the population are based on mutual recruited at approximately 18 weeks of pregnancy
respect. Sub-Saharan African women use prenatal from nine rural villages in West Java, Indonesia,
care extensively when it is accessible; this were followed until 12–15 months of age. Weight,
opportunity must be used to implement evidence- length, morbidity, breastfeeding and food intake
based actions with appropriate and realistic goals. were assessed monthly. Determinants of length and
weight increase and nutritional status reflected by
Z-scores were evaluated using multiple linear
Save the Children. 2000. The state of the world’s regression. Neonatal weight (3.2 +/– 0.5kg) and
mothers 2000. length (49.7 +/– 2.2cm) were reasonable. However,
Abstract: This booklet presents the findings of the growth started to falter at six to seven months of
“State of the World’s Mothers 2000, Save the age, resulting in prevalences of 24% stunting and
Children,” which examines the overall status of 32% underweight at 12 months of age. The
mothers in 106 countries—20 industrialized nations multiple regression models explained 19%–41% of
and 86 in the developing world. Data were based the variation in growth and nutritional status of
on published statistics from governments, infants. Neonatal weight (beta=0.285) and length
international agencies, and research institutions. It (beta=0.492) were the strongest positive predictors
is noted that for mothers, indicators of well-being of weight-for-age and height-for-age Z-scores,
include health status, modern contraceptive use, respectively. Fever was negatively associated with
literacy and participation as national government weight increase (beta=–0.144) and weight-for-age
office holders while for children, they include infant (beta=–0.142) and weight-for-height Z-scores
mortality rates, access to safe water, primary school (beta=–0.255) but not with length increase or
enrollment and nutritional status. Overall, findings height-for-age Z-scores. Intake of complementary
affirm the strong link between the well-being of foods was positively associated with increases in
women and of children. It reveals two factors that weight (beta=0.190) and length (beta=0.179) and
make a vital difference in their well-being: female nutritional status of infants (beta=0.136–0.194). In
education and access to, and use of, family planning conclusion, in this rural population in West Java,
services. The findings also show that national neonatal weight and especially length, reflecting the
wealth alone does not guarantee the welfare of prenatal environment, are the most important
mothers and children. Recommendations from these predictors of infant nutritional status.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
31
to national-level attention: the existence of clear Silva, A. A., M. A. Barbieri, U. A. Gomes, and H.
indicators showing that a problem exists; the Bettiol. 1998. “Trends in low birth weight: a
presence of effective political entrepreneurs to push comparison of two birth cohorts separated by a
the cause; the organization of attention-generating 15-year interval in Ribeirao Preto, Brazil,” Bull.
focusing events that promote widespread concern World Health Organ., vol. 76, no. 1,
for the issue; and the availability of politically pp. 73–84.
palatable policy alternatives that enable national
Abstract: The incidence and some determinants of
leaders to understand that the problem is
low birthweight (LBW) were studied in two
surmountable. The paper presents a case study of
population-based cohorts of singletons born live to
the emergence, waning and re-generation of
families in Ribeirao Preto, Sao Paulo State, Brazil.
political priority for safe motherhood in Indonesia
The first cohort comprised infants born between
over the decade 1987–1997, to highlight how these
June 1978 and May 1979 (6,750 births—
four factors interacted to raise safe motherhood
population survey) and the second, infants born
from near obscurity in the country to national-level
between May and August 1994 (2,990 births—
prominence. While there are contextual factors that
sample survey). The incidence of LBW was 7.2% in
make this case unique, some elements are
1978–1979 and 10.6% in 1994. After adjustment
applicable to all developing countries. The paper
for confounding factors, the following determinants
draws out these dimensions in the hope that
remained significant in 1978–1979: female sex,
greater knowledge surrounding how political will
maternal age > or = 35 years, preterm delivery,
actually has been generated can help shape
less than four antenatal health visits, maternal
strategic action to address this much neglected
smoking, lower level of maternal education, and
global problem.
manual work/unemployment. In 1994, the
significant determinants were preterm delivery,
Shults, R. A., V. Arndt, A. F. Olshan, C. F. Martin, maternal smoking and cesarean section. The
and R. A. Royce. 1999. “Effects of short adjusted percentage population attributable risk
interpregnancy intervals on small-for-gestational (PAR%) fell for the majority of risk factors but
age and preterm births,” Epidemiology, vol. 10, increased for cesarean section, preterm birth,
no. 3, pp. 250–254. multiparity (> or = 5), primiparity and non-
cohabitation. The increase in the rate of LBW from
Abstract: We examined the effects of short 1978–1979 to 1994 was higher for families with
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
interpregnancy intervals on small-for-gestational more qualified occupations, and occurred only for
age and preterm births in a biracial population infants delivered at 36–40 weeks’ gestational age
using North Carolina birth certificate data from and weighing 1,500g–2,499g, i.e. those most likely
1988 to 1994. We defined small-for-gestational age to be born by elective cesarean section. The
birth as being below the 10th percentile on a race-, cesarean section rate rose from 30.3% in
sex-, and parity-specific growth curve after a 1978–1979 to 51.1% in 1994. The increase in LBW
gestation of 37–42 weeks. We defined preterm was probably due to iatrogenic practices associated
birth as a gestation of less than 37 weeks. We with elective cesarean section.
analyzed birth records from all eligible singleton
births to black or white women ages 15–45 years
after an interpregnancy interval of 0–3 months Smith, C. B. 1984. “Birth weights of fetuses
(N=11,451) and a random sample of singleton exposed to diagnostic ultrasound,” J.
births after an interval of 4–24 months Ultrasound Med., vol. 3, no. 9, pp. 395–396.
(N=23,118). We defined interpregnancy interval
Abstract: The birthweights of newborns routinely
exposure categories as 0–3, 4–12, and 13–24
subjected to diagnostic ultrasound antenatally are
months. The multivariate adjusted odds ratio for
compared with the birthweights of infants
small-for-gestational age births after interpregnancy
delivered by the same physician over a similar span
intervals of 0–3 months compared with 13–24-
of time seven years earlier, when diagnostic
month intervals was 1.6 (95% confidence interval
ultrasound was not available. They are also
(CI): 1.4–1.8). The odds ratio for preterm birth
compared with the birthweights of infants
after interpregnancy intervals of 0–3 months was
delivered by a physician in the same rural
1.2 (95% CI: 1.1–1.3). Odds ratios did not vary
community who requested diagnostic ultrasound
substantially by race for either outcome.
for less than 10% of his pregnant patients. There is
no apparent difference between the average weights
of the infants subjected to diagnostic ultrasound
and those who were not.
32
Srinivasan, V., S. Radhakrishna, R. Sudha, M. V. 16 (17%), Type III: 18 (19%), Type IV: 16 (17%).
Malathi, S. Jabbar, R. Ramakrishnan, and T. V. Echocardiography showed 30 cases of left ventricle
Rao. 1995. “Randomized controlled field trial hypertrophy with three cases of systolic
of two antenatal care packages in rural south dysfunction. Thirty-five patients had undergone a
India,” Indian J. Med. Res., vol. 102, cesarean. Forty-seven infants had a birthweight
pp. 86–94. below 2,000g. Maternal mortality was 12.7%,
fetal and neonatal mortality was 50%. There was a
Abstract: A randomized community intervention
21-fold higher chance of cesarean section in
trial was undertaken in 12 subcenters in Karur
hypertensive women (p<4 x 10–4). Neonatal
health unit district, Tamil Nadu, to compare the
mortality was 36 times higher (p<4 x 10–6) than in
efficacy of two antenatal care packages. A newly
the control group with a birthweight lower
recommended ‘high-risk’ strategy package and a
birthweight 975g (p<10–6). Women suffering from
uniform package recommended by the Tamil Nadu
toxemia gave birth to children having a lower
Government were each implemented in four
birthweight (–543g) (p<5 x 10–3), but, there was
randomly selected subcenters by the study team,
no significant difference concerning cesarean
and the latter was also delivered by routine health
(p<7 x 10–1) maternal, fetal and neonatal mortality
services in the four remaining subcenters. Analyses
(p<9 x 10–1) compared with other sub-groups.
were based on 294 pregnant women on the high-
CONCLUSION: In developing countries,
risk package (HR), 242 on the Tamil Nadu
hypertension in pregnant women is a severe
Government (TNG) package and 335 women in
condition responsible for disease and handicaps
the control series. The HR package reduced the
which could be avoidable at little cost through a
differences between the high-risk women and the
better policy of detection and good quality
others in mean hemoglobin and the percentages
multidisciplinary management.
with preventable neonatal morbidity and low
birthweight, and consequently the overall outcome
was better in the HR series than in the TNG series. Tinker, A. and M. A. Koblinsky. 1993. Making
Finally, the results with the TNG package were motherhood safe. World Bank.
better when it was implemented by the study team
than by the routine health services, in terms of Abstract: Most women in the developing world
preventable maternal morbidity and preventable lack access to modern methods of contraception
perinatal morbidity, but there was no impact on and to adequate prenatal care. Even in countries
birthweight. with relatively well-developed health systems,
preventable maternal illness and death persist
because of inappropriate management of the
Thiam, M., M. Goumbala, S. B. Gning, P. D. Fall, complications of pregnancy.
C. Cellier, and J. L. Perret. 2003. “Maternal This paper draws on experience and research
and fetal prognosis of hypertension and in both developing and industrial countries. That
pregnancy in Africa (Senegal),” J. Gynecol. evidence shows that community-based approaches
Obstet. Biol. Reprod. (Paris), vol. 32, no. 1, such as local family planning and the training and
pp. 35–38. deployment of midwives help to reduce maternal
mortality in high-mortality settings. Prenatal care
Abstract: OBJECTIVES: The aims of this study
and more childbirth services are identified as
were to record the different types of hypertension
among the most cost-effective of government
associated with pregnancy and to assess the
interventions for improving child health.
incidence of hypertension and its gravity in
Senegal. METHODS: Over a two-year period, a
cohort of pregnant women with hypertension UNICEF. 2002. Programming for safe
according to the American working group motherhood: guidelines for maternal and
classification of hypertension and pregnancy, was neonatal survival.
studied. A group of 47 non-hypertensive women
Abstract: This guideline compiles a set of multi-
GENERAL ASPECTS
33
and neonatal mortality more generally. The guideline an equal number of pairs serving as controls,
reviews the causes—direct and indirect—of maternal precisely matched for socioeconomic status,
illness and death; lessons learned from field maternal literacy, parity of the mother, birth
experience about the best ways to promote maternal interval, age, height and weight of mother,
survival (including improving nutritional status, gestational age and sex of the baby. The
expanding girls’ access to education, ensuring skilled birthweight, length, and circumference of skull
attendance at delivery and building effective referral were studied. A statistically significant lower
systems); and key operational strategies. It then birthweight by an average of 395.3g and lower
provides a set of chapters focused on specific, cost- birth length by 0.518cm was observed in the
effective interventions and actions. Among these are: tobacco consumer group. Tobacco consumption
promoting safe motherhood as a human right; exceeding 200mg/day during pregnancy distinctly
improving the nutritional status of girls and women; influenced birthweight, particularly in the forms
expanding access to health care during pregnancy that were more likely to be ingested than merely
and delivery; providing maternal and neonatal care chewed. In qualitative terms, tobacco consumption
in emergency situations; and developing or during pregnancy significantly diminished
strengthening programs to promote reproductive birthweight and length. What remains to be studied
health, reduce teenage pregnancy, provide services to is the quantitative correlation between toxic
women and infants with HIV/AIDS, and reduce the metabolites of tobacco and fetal outcome.
incidence of gender violence and discrimination.
Each chapter follows a similar format, stating
objectives, defining a needs assessment, detailing Walsh, J. A., A. R. Measham, C. N. Feifer, and P. J.
interventions at various levels (e.g., national policy Gertler. 1994. “The impact of maternal health
making, health system and community), and improvement on perinatal survival: cost-
describing indicators for monitoring and evaluation. effective alternatives,” Int. J. Health Plann.
Throughout the guideline, examples of actual Manage., vol. 9, no. 2, pp. 131–149.
programs are provided to illustrate recommended Abstract: Each year, an estimated half million
interventions. Also included is a list of publications women die from complications related to child
on safe motherhood. birth either during pregnancy, delivery or within
131 pp. English. French and Spanish forthcoming. 42 days afterwards. When pregnant women have
complications, their infants are at greater risk of
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
ORDERING INFORMATION: Document can be becoming ill, permanently disabled or dying. For
ordered by contacting your nearest UNICEF field every maternal death, there are at least 20 infant
office. A list of field offices can be found online at: deaths: stillbirths, neonatal or postneonatal deaths.
http://www.unicef.org/uwwide/ffo.htm Altogether, an estimated seven million infants each
Or mail, phone or fax the request and order to: year die perinatally (stillborn or deaths within the
UNICEF first week of life). Low-cost, feasible, and effective
Publications Section intervention strategies include: a) improved family
3 UN Plaza, 9th Floor planning and abortion services; b) obstetric care at
New York, NY 10017 delivery; and, c) prenatal services. Two
Phone: 1-212-326-7309 hypothetical populations of one million (a low
Fax: 1-212-326-7518 mortality and a high mortality country) are used to
illustrate maternal and perinatal program strategies
and priorities. In countries with high fertility, major
Verma, R. C., M. Chansoriya, and K. K. Kaul.
reductions in maternal and infant deaths result
1983. “Effect of tobacco chewing by mothers
both from reductions in the number of pregnancies
on fetal outcome,” Indian Pediatr., vol. 20,
through family planning and from improved
no. 2, pp. 105–111.
obstetric care. Where fertility is already low,
Abstract: While the adverse effect of tobacco reductions result almost entirely from improved
smoking by mothers on fetal outcome has been obstetric and prenatal care. The investments
extensively documented in literature, effect of required are relatively low, while the potential
consumption of tobacco in other forms, such as gains are great. The cost to avert each death in a
eating, chewing, etc., as a traditional practice in high mortality population is estimated between
some communities in India and its neighboring $800 and $1,500 or as low as $0.50 per capita per
countries has received scant attention. In the year. The priorities for programs targeting maternal
present study, 70 mother-newborn pairs, where and perinatal health depend on demographic,
mothers consumed tobacco, were compared with ecologic and economic factors, and should include
34
the promotion of good health, not merely the field work; and suggestions for analysis and
avoidance of death. More operational research is interpretation of the data collected. The manual
required on various aspects of maternal and comes with a diskette with the survey forms in
perinatal health; in particular, on the cost- both word processing and EPI-Info formats and the
effectiveness of different service components. surveyor’s manual and model forms in word
processing formats.
field-based assessment of health system capacities Organ., vol. 73 Suppl, pp. 1–98.
to provide maternal health services, comprising
Abstract: The nutritional status of a woman before
protocols, checklists, and model forms for:
and during pregnancy is critical to both her infant’s
interviewing health personnel, clients, and TBAs;
and her own health and survival. It determines her
assessing supplies and equipment; and reviewing
well-being and that of the fetus and child, and in
records. The manual also contains materials to
turn the health and reproductive capacity of the
conduct a five day workshop to train needs
next generation’s mothers. Anthropometric
assessment surveyors; instructions for surveyors on
35
assessment of nutritional status during the health care system and without the need for
reproductive cycle, particularly during pregnancy, sophisticated equipment, expensive drugs, or
is a widely used, low-technology procedure that additional resources and facilities.
has seldom been rigorously evaluated. The need to The document, which is addressed to national
provide sound technical advice on the utility and decision-makers and health planners, provides both
feasibility of selected anthropometric indicators for an explanation of general strategies crucial to the
routine application in primary health care, success of the Package and a detailed guide to the
especially in circumstances where resources are actions required to implement each of the 18 core
limited, led to a meta-analysis of 25 data sets on interventions. Concerning strategic issues, the book
maternal anthropometry and pregnancy outcomes advocates an integrated approach to service
from 20 different countries, providing information delivery aimed at reducing the number of high-risk
on more than 111,000 births and quantifying to and unwanted pregnancies, reducing the number of
what degree anthropometric measurements are complications, and reducing case fatality rates
useful and efficient in predicting maternal and child when complications occur. Essential service-related
outcomes of pregnancy in the community and at components of the package are identified as family
home in different country settings. The next stage planning, quality antenatal care, clean and safe
will be the demonstration of the operational value delivery, and access to essential obstetric care for
of the findings of this study through their high-risk pregnancies and complications.
successful application in service settings on a large
Available at:
scale.
http://www.who.int/dsa/cat98/mat8.htm#Mother-
BabyPackage:ImplementingSafeMotherhoodin
World Health Organization. 1994. Antenatal Care: Countries
Report of a Technical Working Group.
Abstract: This report focuses attention on drawing Zaren, B., G. Lindmark, and L. Bakketeig. 2000.
up recommendations on antenatal care and “Maternal smoking affects fetal growth more in
outlining the tasks and procedures health workers the male fetus,” Paediatr. Perinat. Epidemiol.,
are expected to perform at different levels of the vol. 14, no. 2, pp. 118–126.
health care system. It also examines how to
Abstract: This study investigated the association
optimize antenatal care in terms of clinical tasks
between maternal cigarette smoking and fetal
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
36
half of pregnancy in both males and females. A Zhu, B. P., R. T. Rolfs, B. E. Nangle, and J. M.
greater intrauterine growth velocity and a different Horan. 1999. “Effect of the interval between
hormonal milieu are suggested as possible pregnancies on perinatal outcomes,” N. Engl. J.
explanations of the greater male susceptibility. Med., vol. 340, no. 8, pp. 589–594.
Abstract: BACKGROUND: A short interval
Zeitlin, J. A., P. Y. Ancel, M. J. Saurel-Cubizolles, between pregnancies has been associated with
and E. Papiernik. 2001. “Are risk factors the adverse perinatal outcomes. Whether that
same for small for gestational age versus other association is due to confounding by other risk
preterm births?” Am. J. Obstet. Gynecol., factors, such as maternal age, socioeconomic
vol. 185, no. 1, pp. 208–215. status, and reproductive history, is unknown.
METHODS: We evaluated the interpregnancy
Abstract: OBJECTIVES: This article explores interval in relation to low birthweight, preterm
whether the impact of social and demographic risk birth, and small size for gestational age by
factors for preterm birth differs for small for analyzing data from the birth certificates of
gestational age preterm births versus other preterm 173,205 singleton infants born alive to multiparous
births. STUDY DESIGN: This was a European case mothers in Utah from 1989 to 1996. RESULTS:
control study of the determinants of preterm birth Infants conceived 18 to 23 months after a previous
(4,700 cases and 6,460 controls). Small for live birth had the lowest risks of adverse perinatal
gestational age and non-small for gestational age outcomes; shorter and longer interpregnancy
preterm births were compared with a control group intervals were associated with higher risks. These
of term births; relationships were explored further associations persisted when the data were stratified
by stratifying preterm births into subgroups by according to and controlled for 16 biologic,
mode of onset, the presence of hypertension, and sociodemographic, and behavioral risk factors. As
gestational age. RESULTS: Of the social and compared with infants conceived 18 to 23 months
demographic risk factors for preterm birth after a live birth, infants conceived less than six
identified in this sample, high maternal age, months after a live birth had odds ratios of
smoking, and low and high maternal body mass 1.4 (95% confidence interval (CI): 1.3–1.6) for low
index have a stronger effect on small for birthweight, 1.4 (95% CI: 1.3–1.5) for preterm
gestational age preterm births. In contrast, birth, and 1.3 (95% CI: 1.2–1.4) for small size for
obstetric history, maternal education, and marital gestational age; infants conceived 120 months or
status have similar effects regardless of birthweight. more after a live birth had odds ratios of
Hypertension during pregnancy is strongly 2.0 (95% CI: 1.7–2.4); 1.5 (95% CI: 1.3–1.7), and
associated with small for gestational age preterm 1.8 (95% CI: 1.6–2.0) for these three adverse
birth and contributes to an explanation of observed outcomes, respectively, when we controlled for all
differences. CONCLUSIONS: These results 16 risk factors with logistic regression.
underline the importance of considering fetal CONCLUSIONS: The optimal interpregnancy
growth restriction in the analysis of risk factors for interval for preventing adverse perinatal outcomes
preterm birth. is 18 to 23 months.
GENERAL ASPECTS
37
Maternal Nutrition
Agarwal, K. N., D. K. Agarwal, and K. P. Mishra. Allen, L. H. 2000. “Anemia and iron deficiency:
1991. “Impact of anaemia prophylaxis in effects on pregnancy outcome,” Am. J. Clin.
pregnancy on maternal haemoglobin, serum Nutr., vol. 71, no. 5 Suppl pp. 1280S–1284S.
ferritin and birth weight,” Indian J. Med. Res.,
Abstract: This article reviews current knowledge of
vol. 94, pp. 277–280.
the effects of maternal anemia and iron deficiency
Abstract: A total of 418 pregnant women at on pregnancy outcome. A considerable amount of
16–24 weeks’ of gestation, from six subcenters of a information remains to be learned about the
rural block of Varanasi district were selected. benefits of maternal iron supplementation on the
Pregnant women (137 of 215) from three health and iron status of the mother and her child
subcenters received the supplementation of 60mg during pregnancy and postpartum. Current
elemental iron as ferrous sulphate combined with knowledge indicates that iron deficiency anemia in
500 micrograms folic acid, daily for 100 days pregnancy is a risk factor for preterm delivery and
(study group) and 123 (of 203) pregnant women subsequent low birthweight, and possibly for
from the other three subcenters without inferior neonatal health. Data are inadequate to
supplementation (control group) could be determine the extent to which maternal anemia
evaluated for their pregnancy outcome. The might contribute to maternal mortality. Even for
hemoglobin and serum ferritin levels increased women who enter pregnancy with reasonable iron
significantly in the study group. In the latter, the stores, iron supplements improve iron status during
mean birthweight was 2.88 +/– 0.41kg with low pregnancy and for a considerable length of time
birthweight incidence of 20.4% as compared to the postpartum, thus providing some protection
control figures of 2.59 +/– 0.34kg and 37.9% against iron deficiency in the subsequent
respectively. The incidence of low birthweight was pregnancy. Mounting evidence indicates that
further reduced to 12.1% if the supplementation maternal iron deficiency in pregnancy reduces fetal
could be started by 16–19 weeks of gestation. iron stores, perhaps well into the first year of life.
This deserves further exploration because of the
tendency of infants to develop iron deficiency
Ahluwalia, I. B., V. K. Hogan, L. Grummer- anemia and because of the documented adverse
Strawn, W. R. Colville, and A. Peterson. 1998. consequences of this condition on infant
“The effect of WIC participation on small-for- development. The weight of evidence supports the
gestational-age births: Michigan, 1992,” Am. J. advisability of routine iron supplementation during
Public Health, vol. 88, no. 9, pp. 1374–1377. pregnancy.
Abstract: OBJECTIVE: This study examined the
relationship between enrollment in the Special
Berry, R. J., Z. Li, J. D. Erickson, S. Li, C. A.
Supplemental Nutrition Program for women,
Moore, H. Wang, J. Mulinare, P. Zhao, L. Y.
Infants, and Children (WIC) and delivery of small-
Wong, J. Gindler, S. X. Hong, and A. Correa.
for-gestational-age infants. METHODS: WIC
1999. “Prevention of neural-tube defects with
records were linked with birth certificates for
folic acid in China. China-U.S. Collaborative
1,992 full-term births; 41,234 WIC records and
Project for Neural Tube Defect Prevention
1,834 non-WIC records were identified. Length of
[corrected; erratum to be published],” N. Engl.
participation was defined by gestational age at
J. Med., vol. 341, no. 20, pp. 1485–1490.
enrollment. Logistic regression was used to
examine the association between WIC participation Abstract: BACKGROUND AND METHODS:
MATERNAL NUTRITION
39
to take a pill containing 400 microg of folic acid whatever the mothers’ treatment had been.
alone daily from the time of their premarital However, a significant difference appeared for the
examination until the end of their first trimester of gestational age and, therefore, the height and
pregnancy. RESULTS: Among the fetuses or infants weight. Folic acid supplementation during
of 130,142 women who took folic acid at any time pregnancy increased its duration by virtually one
before or during pregnancy and 117,689 women week.
who had not taken folic acid, we identified
102 and 173, respectively, with neural-tube defects.
Among the fetuses or infants of women who Bolzan, A., L. Guimarey, and M. Norry. 1999.
registered before their last menstrual period and “Relationship between the nutritional status of
who did not take any folic acid, the rates of neural- pregnant adolescents and fetal growth,”
tube defects were 4.8 per 1,000 pregnancies of at Medicina (B Aires), vol. 59, no. 3,
least 20 weeks’ gestation in the northern region pp. 254–258.
and 1.0 per 1,000 in the southern region. Among Abstract: In order to identify differences in growth
the fetuses or infants of the women with and nutritional status between early (up to
periconceptional use of folic acid, the rates were 17 years old) and late (17 to 19 years old)
1.0 per 1,000 in the northern region and 0.6 per adolescent mothers during pregnancy and to
1,000 in the southern region. The greatest measure the risk to have an intrauterine growth
reduction in risk occurred among the fetuses or retardation (IGR: birthweight <10 degrees
infants of a subgroup of women in the northern percentile), a retrospective longitudinal
region with periconceptional use who took folic anthropometric study was carried out in 300
acid pills more than 80% of the time (reduction in adolescent pregnancies. Nutritional status was
risk, 85% as compared with the fetuses or infants estimated according to the body mass index
of women who registered before their last (weight/height2)—measured during the first
menstrual period and who took no folic acid; 95% (<20 weeks) and last (>33 weeks) prenatal
confidence interval (CI): 62%–94%) [corrected]. In control—and by the weight gain during pregnancy.
the southern region the reduction in risk among the When a mother had a weight gain <25 degrees
fetuses or infants of women with periconceptional percentile she was considered at risk to have an
use of folic acid was also significant (reduction in IGR. Neonatal anthropometry included
risk, 41%; 95% CI: 3%–64%). CONCLUSIONS: birthweight, recumbent length, cephalic perimeter
Periconceptional intake of 400 microg of folic acid
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
40
data are available on whether prenatal zinc circumferences and skinfold thicknesses were
supplementation improves maternal and neonatal assessed on day one. At delivery, 1,016 remained in
zinc status. OBJECTIVE: We studied whether the study; duration of pregnancy was known for all
maternal zinc supplementation improved the zinc women, and birthweight information was available
status of mothers and neonates participating in a for 957 newborns. No differences were noted in
supplementation trial in a shantytown in Lima, duration of pregnancy (39.4 +/– 2.2 vs. 39.5 +/–
Peru. DESIGN: Beginning at gestation week 10–24, 2.0 weeks) or birthweight (3,267 +/– 461 vs.
1,295 mothers were randomly assigned to receive 3,300 +/– 498g) by prenatal supplement type (iron
prenatal supplements containing 60mg Fe and 250 + folate + zinc vs. iron + folate; P>0.05), and there
microg folate, with or without 15mg Zn. Venous were no differences in the rates of preterm
blood and urine samples were collected at (<37 weeks) or post-term (>42 weeks) delivery, low
enrollment, at gestation week 28–30, and at birthweight (<2,500g) or high birthweight
gestation week 37–38. At birth, a sample of cord (>4,000g). Finally, there were no differences by
vein blood was collected. We measured serum zinc prenatal supplement type in newborn head
concentrations in 538 women, urinary zinc circumference, crownheel length, chest
concentrations in 521 women, and cord zinc circumference, mid-upper arm circumference, calf
concentrations in 252 neonates. RESULTS: At circumference or skinfold thickness at any of three
28–30 and 37–38 weeks, mothers receiving zinc sites. Adjustment for covariates and confounding
supplements had higher serum zinc concentrations factors did not alter these results. Adding zinc to
than mothers who did not receive zinc (8.8 +/– 1.9 prenatal iron and folate tablets did not affect
compared with 8.4 +/– 1.5 micromol/L and duration of pregnancy or size at birth in this
8.6 +/– 1.5 compared with 8.3 +/– 1.4 micromol/L, population.
respectively). Urinary zinc concentrations were also
higher in mothers who received supplemental zinc
(P<0.05). After adjustment for covariates and Ceesay, S. M., A. M. Prentice, T. J. Cole, F. Foord,
confounding factors, neonates of mothers receiving L. T. Weaver, E. M. Poskitt, and R. G.
zinc supplements had higher cord zinc Whitehead. 1997. “Effects on birth weight and
concentrations than neonates of mothers who did perinatal mortality of maternal dietary
not receive zinc (12.7 +/– 2.3 compared with supplements in rural Gambia: 5 year
12.1 +/– 2.1 micromol/L). Despite randomized controlled trial,” BMJ, vol. 315,
supplementation, maternal and neonatal zinc no. 7111, pp. 786–790.
concentrations remained lower than values Abstract: OBJECTIVE: To test the efficacy in terms
reported for well-nourished populations. of birthweight and infant survival of a diet
CONCLUSION: Adding zinc to prenatal iron and supplement program in pregnant African women
folate tablets improved maternal and neonatal zinc through a primary healthcare system. DESIGN:
status, but higher doses of zinc are likely needed to Five-year controlled trial of all pregnant women in
further improve maternal and neonatal zinc status 28 villages randomized to daily supplementation
in this population. with high energy groundnut biscuits (4.3 MJ/day)
for about 20 weeks before delivery (intervention)
or after delivery (control). SETTING: Rural
Caulfield, L. E., N. Zavaleta, A. Figueroa, and Z.
Gambia. SUBJECTS: Chronically undernourished
Leon. 1999. “Maternal zinc supplementation
women (twin bearers excluded), yielding 2,047
does not affect size at birth or pregnancy
singleton live births and 35 stillbirths. MAIN
duration in Peru,” J. Nutr., vol. 129, no. 8,
OUTCOME MEASURES: birthweight; prevalence
pp. 1563–1568.
of low birthweight (<2,500g); head circumference;
Abstract: To estimate the effect of maternal zinc birth length; gestational age; prevalence of
deficiency on pregnancy outcomes, we conducted a stillbirths; neonatal and postneonatal mortality.
MATERNAL NUTRITION
zinc supplementation trial in an urban shantytown RESULTS: Supplementation increased weight gain
in Lima, Peru, a population with habitual low zinc in pregnancy and significantly increased
intakes. Beginning at 10–24 weeks’ gestation, birthweight, particularly during the nutritionally
1,295 mothers were randomly assigned to receive debilitating hungry season (June to October).
prenatal supplements containing 60mg iron and Weight gain increased by 201g (P<0.001) in the
250mg folate, with or without 15mg zinc. Women hungry season, by 94g (P<0.01) in the harvest
were followed up monthly during pregnancy. At season (November to May), and by 136g (P<0.001)
birth, newborn weight was recorded, and over the whole year. The odds ratio for low
crownheel length, head circumference and other birthweight babies in supplemented women was
41
0.61 (95% confidence interval 0.47 to 0.79, adding zinc may negate the beneficial effect of iron
P<0.001). Head circumference was significantly and folic acid on birthweight. Research is needed
increased (P<0.01), but by only 3.1mm. Birth to further our understanding of nutrient-nutrient
length and duration of gestation were not affected. interactions.
Supplementation significantly reduced perinatal
mortality: the odds ratio was 0.47 (0.23 to 0.99,
P<0.05) for stillbirths and 0.54 (0.35 to 0.85, Christian, P. 2002. “Maternal nutrition, health,
P<0.01) for all deaths in first week of life. and survival,” Nutr. Rev., vol. 60, no. 5 Pt 2,
Mortality after seven days was unaffected. pp. S59–S63.
CONCLUSION: Prenatal dietary supplementation Abstract: The burden of maternal morbidity and
reduced retardation in intrauterine growth when mortality in developing countries is high. Each
effectively targeted at genuinely at-risk mothers. year, 600,000 women die from pregnancy-related
This was associated with a substantial reduction in causes and 62 million women suffer from
the prevalence of stillbirths and in early neonatal morbidity and complications of pregnancy. The
mortality. The intervention can be successfully extent to which maternal nutrition can improve
delivered through a primary healthcare system. maternal health and survival is not well
understood. Excluding deaths due to induced
abortions, the other four main causes of maternal
Christian, P. 2003. “Micronutrients and
mortality (preeclampsia, hemorrhage, obstructed
reproductive health issues: an international
labor, and infection) may be amenable to nutrition
perspective,” J. Nutr., vol. 133, no. 6,
interventions. The role of calcium in reducing the
pp. 1969S–1973S.
incidence of preeclampsia and hypertension is
Abstract: Micronutrients may have a role in promising, but more research in deficient
enhancing reproductive health of women living in populations is urgently needed. Antenatal iron
the developing world. Two illustrative supplementation, although frequently
micronutrients, zinc and vitamin A, have received recommended to prevent anemia during pregnancy,
some attention in this regard. Numerous animal has had little program success. Severe anemia may
experiments and observational studies suggest the be an important cause of maternal mortality, but
potential role of zinc deficiency in labor and convincing evidence is lacking on the health
delivery-related complications such as premature consequences of mild-to-moderate maternal
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
rupture of membrane, placental abruption, preterm anemia. Knowledge of the etiology of anemia is
labor and inefficient uterine contraction. These important in identifying effective strategies for
associations have not been confirmed in combating it. Other vitamins such as folate, B12,
supplementation studies. Zinc does not appear to and vitamin A may enhance the effect of iron
be a limiting factor in intrauterine growth in the supplementation in populations where multiple
developing world, contrary to some evidence of its nutrition deficiencies exist. Maternal night
suggested benefit among women residing in blindness is widespread in South Asian women. In
industrialized countries. One study in Nepal found Nepal, this condition is associated with markedly
that maternal vitamin A or beta-carotene increased risks of vitamin A deficiency, anemia,
supplementation reduces pregnancy-related morbidity, and maternal and infant mortality.
mortality but not infant mortality. These findings These findings need to be replicated elsewhere in
are corroborated by observations of the South Asia. One study has shown vitamin A and
significantly higher risk of mortality among night- beta carotene supplementation to reduce maternal
blind women compared to non-night-blind women mortality and morbidity. These findings need
long after the termination of pregnancy and the testing in different settings with emphasis on
resolution of night blindness. Maternal multiple investigating the mechanisms of the effect. The area
micronutrient supplementation needs more careful of prepregnancy nutrition and its influence on
evaluation before its use in large-scale programs. prolonged and obstructed labor is wide open for
Two recent trials indicated that a prenatal multiple investigation. The scope for research in the area of
micronutrient supplement provides no added maternal nutrition and health is large and the onus
advantage over iron and folate in reducing is on nutritionists to bring to the forefront the role
outcomes such as low birthweight and probably no of nutrition in maternal health and survival.
survival benefit. Data are also suggestive that
42
Christian, P., S. K. Khatry, J. Katz, E. K. Pradhan, asphyxia. Important indirect causes include low
S. C. LeClerq, S. R. Shrestha, R. K. Adhikari, birthweight and hypothermia. The present body of
A. Sommer, and K. P. West, Jr. 2003. “Effects of work on multiple micronutrient interventions is not
alternative maternal micronutrient supplements sufficient for us to draw conclusions on their
on low birth weight in rural Nepal: double effects on neonatal well-being. Because studies have
blind randomized community trial,” BMJ, generally concentrated on single micronutrients and
vol. 326, no. 7389, p. 571. a range of outcomes, this paper reviews the
findings for individual nutrients and then
Abstract: OBJECTIVE: To assess the impact on
summarizes the situation. The evidence for the
birth size and risk of low birthweight of alternative
contribution of micronutrient deficiencies to
combinations of micronutrients given to pregnant
perinatal mortality and duration of gestation is
women. DESIGN: Double blind cluster randomized
limited, and the evidence base for individual
controlled trial. SETTING: Rural community in
micronutrient effects on neonatal mortality and
south eastern Nepal. PARTICIPANTS: 4,926
morbidity is patchy. To translate knowledge into
pregnant women and 4,130 live born infants.
policy, community evaluations of effect and an
INTERVENTIONS: Four hundred and twenty-six
expanded evidence base that includes affordability,
communities were randomized to five regimens in
acceptability and scalability are also required. A
which pregnant women received daily supplements
balance between supply-side and demand-side
of folic acid, folic acid-iron, folic acid-iron-zinc, or
interventions must be struck, with an emphasis on
multiple micronutrients all given with vitamin A,
effect and sustainability. Among the key
or vitamin A alone (control). MAIN OUTCOME
requirements are randomized, controlled
MEASURES: birthweight, length, and head and
community effectiveness trials of the effect of
chest circumference assessed within 72 hours of
micronutrient supplementation in pregnancy on
birth. Low birthweight was defined <2,500g.
perinatal mortality and neurodevelopment, studies
RESULTS: Supplementation with maternal folic
on improving adherence and studies on the relation
acid alone had no effect on birth size. Folic acid-
between micronutrient deficiencies and sepsis and
iron increased mean birthweight by 37g (95%
neonatal encephalopathy. It would also be helpful
confidence interval: 16g to 90g) and reduced the
to look at mechanisms for bringing the
percentage of low birthweight babies (<2,500g)
periconceptional period within the ambit of trials.
from 43% to 34% (16%; relative risk=0.84,
0.72 to 0.99). Folic acid-iron-zinc had no effect on
birth size compared with controls. Multiple Czeizel, A. E. 1993. “Prevention of congenital
micronutrient supplementation increased abnormalities by periconceptional multivitamin
birthweight by 64g (12g to 115g) and reduced the supplementation,” BMJ, vol. 306, no. 6893,
percentage of low birthweight babies by pp. 1645–1648.
14% (0.86, 0.74 to 0.99). None of the supplement
combinations reduced the incidence of preterm Abstract: OBJECTIVE: To study the effect of
births. Folic acid-iron and multiple micronutrients periconceptional multivitamin supplementation on
increased head and chest circumference of babies, neural tube defects and other congenital
but not length. CONCLUSIONS: Antenatal folic abnormality entities. DESIGN: Randomized
acid-iron supplements modestly reduce the risk of controlled trial of supplementation with
low birthweight. Multiple micronutrients confer no multivitamins and trace elements. SETTING:
additional benefit over folic acid-iron in reducing Hungarian family planning program. SUBJECTS:
this risk. 4,156 pregnancies with known outcome and
3,713 infants evaluated in the eighth month of life.
INTERVENTIONS: A single tablet of a
Costello, A. M. and D. Osrin. 2003. multivitamin including 0.8mg of folic acid or trace
“Micronutrient status during pregnancy and elements supplement daily for at least one month
MATERNAL NUTRITION
outcomes for newborn infants in developing before conception and at least two months after
countries,” J. Nutr., vol. 133, no. 5 Suppl 2, pp. conception. MAIN OUTCOME MEASURES:
1757S–1764S. Number of major and mild congenital
abnormalities. RESULTS: The rate of all major
Abstract: More than nine million neonatal deaths
congenital abnormalities was significantly lower in
occur each year, 98% of them in developing
the group given vitamins than in the group given
countries. Neonatal deaths account for two-thirds
trace elements and this difference cannot be
of deaths in infancy and 40% of deaths before age
explained totally by the significant reduction of
five years. The major direct causes of neonatal
neural tube defects. The rate of major congenital
death are infections, preterm delivery and
43
abnormalities other than neural tube defects and de Silva, N. R., J. L. Sirisena, D. P. Gunasekera, M.
genetic syndromes was 9.0/1,000 in pregnancies M. Ismail, and H. J. de Silva. 1999. “Effect of
with known outcome in the vitamin group and mebendazole therapy during pregnancy on birth
16.6/1,000 in the trace element group; relative risk outcome,” Lancet, vol. 353, no. 9159,
1.85 (95% CI: 1.02–3.38); difference, 7.6/1,000. pp. 1145–1149.
The rate of all major congenital abnormalities
Abstract: BACKGROUND: In areas endemic for
other than neural tube defects and genetic
hookworm, routine antenatal mebendazole therapy
syndromes diagnosed up to the eighth month of life
could greatly reduce the prevalence of anemia in
was 14.7/1,000 informative pregnancies in the
pregnancy. At present, however, this is not a widely
vitamin group and 28.3/1,000 in the trace element
accepted control strategy because of a lack of data
group; relative risk 1.95 (1.23 to 3.09); difference,
on the safety of the drug. We assessed the effect of
13.6/1,000. The rate of some congenital
mebendazole therapy during pregnancy on birth
abnormalities was lower in the vitamin group than
outcome. METHODS: A cross-sectional study was
in the trace element group but the differences for
done in Sri Lanka, where prescription of
each group of abnormalities were not significant.
mebendazole to women in the second trimester of
CONCLUSIONS: Periconceptional multivitamin
pregnancy is recommended. Two hospitals were
supplementation can reduce not only the rate of
chosen for the study, and women who gave birth
neural tube defects but also the rate of other major
there between May, 1996, and March, 1997, were
non-genetic syndromatic congenital abnormalities.
recruited. We compared the rates of major
Further studies are needed to differentiate the
congenital defects, stillbirth, perinatal death, and
chance effect and vitamin dependent effect.
low birthweight (< or = 1,500g) among babies of
mothers who had taken mebendazole during
de Onis, M., J. Villar, and M. Gulmezoglu. 1998. pregnancy with those whose mothers had not taken
“Nutritional interventions to prevent an anthelmintic (controls). FINDINGS: The rate of
intrauterine growth retardation: evidence from major congenital defects was not significantly
randomized controlled trials,” Eur. J. Clin. higher in the mebendazole group than in the
Nutr., vol. 52 Suppl 1, pp. S83–S93. control group (97 [1.8%] of 5,275 vs. 26 [1.5%]
of 1,737; odds ratio 1.24 [95% CI: 0.8–1.91],
Abstract: This report summarizes the evidence p=0.39). Among 407 women who had taken
from systematic reviews of randomized controlled mebendazole in the first trimester (contrary to
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
trials on the effectiveness of nutritional medical advice), 10 (2.5%) had major congenital
interventions aimed at reducing intrauterine growth defects (odds ratio vs. controls 1.66 [0.81–3.56],
retardation (IUGR). There were 12 interventions p=0.23). The proportions of stillbirths and
including protein-energy, vitamin, mineral, and fish perinatal deaths were significantly lower in the
oil supplementation, as well as the prevention and mebendazole group (1.9 vs. 3.3%, 0.55
treatment of anemia and hypertensive disorders. A [95% CI: 0.4–0.77]), as was the proportion of low
primary concern is the limited data supporting the birthweight babies (1.1 vs. 2.3%, 0.47
effectiveness of recommended nutritional [95% CI: 0.32–0.71]). INTERPRETATION:
interventions during pregnancy, some of which are Mebendazole therapy during pregnancy is not
widely used even in women without nutritional associated with a significant increase in major
deficiencies. Overall, with the exception of perhaps congenital defects, but our results indicate that it
balanced protein/energy supplementation (typical should be avoided during the first trimester. This
odds ratio: 0.77; 95% CI: 0.58–1.01), no effective therapy could offer beneficial effects to pregnant
nutritional interventions for reducing the risk of women in developing countries, where intestinal
IUGR have been demonstrated. Other helminthiases are endemic.
interventions, such as zinc, folate and magnesium
supplementation during gestation, merit further
research which should be conducted among Delange, F. 1996. “Administration of iodized oil
populations at risk of IUGR, using larger sample during pregnancy: a summary of the published
sizes, and addressing coexisting factors limiting evidence,” Bull. World Health Organ., vol. 74,
fetal growth. Appropriate combinations of no. 1, pp. 101–108.
interventions should be a priority for evaluation as
Abstract: This brief review of the available studies
it is unlikely that a single factor will reduce a
confirms that the administration of iodized oil
multicausal outcome like IUGR that is so
before or during pregnancy prevents endemic
dependent on socioeconomic disparities.
cretinism and brain damage by correcting iodine
44
deficiency and thyroid function in pregnant <10th percentile, which probably underestimates
women, fetuses, neonates, infants and children. the number failing to achieve full growth potential.
The potential benefits derived from using iodized Birthweight is a crude measure of the dynamic
oil immediately before or during pregnancy greatly process of fetal growth and does not capture effects
outweigh the potential risks in areas of moderate of fetal undernutrition on body composition and
and severe prevalence of iodine-deficiency the development of specific tissues. The link
disorders, where iodized salt is not yet available. between maternal nutrition and fetal nutrition is
indirect. The fetus is nourished by a complex
supply line that includes the mother’s diet and
DeLong, G. R., P. W. Leslie, S. H. Wang, X. M. absorption, endocrine status and metabolism,
Jiang, M. L. Zhang, M. Rakeman, J. Y. Jiang, cardiovascular adaptations to pregnancy and
T. Ma, and X. Y. Cao. 1997. “Effect on infant placental function. Micronutrients are essential for
mortality of iodination of irrigation water in a growth, and maternal micronutrient deficiency,
severely iodine-deficient area of China,” Lancet, frequently multiple in developing countries, may be
vol. 350, no. 9080, pp. 771–773. an important cause of IUGR. Supplementation of
Abstract: BACKGROUND: Hotien county in undernourished mothers with micronutrients has
Xinjiang province, China, is an area of severe several benefits but there is little hard evidence of
iodine deficiency and has a high infant mortality improved fetal growth. However, this has been
rate. We investigated whether iodine replacement inadequately tested. Most trials have only used
through iodination of the irrigation water would single micronutrients and many were inconclusive
decrease infant mortality. METHODS: We added because of methodological problems. Several food-
potassium iodate to irrigation water over a 2- to based studies (some uncontrolled) suggest benefits
4-week period beginning in 1992 in certain areas from improving maternal dietary quality with
of three townships (Tusala, Long Ru, and Bakechi). micronutrient-dense foods. One trial of a
Logistic regression analysis was used to compare multivitamin supplement (HIV-positive mothers,
the odds ratios for infant and neonatal mortality in Tanzania) showed increased birthweight and fewer
treated and intreated areas. FINDINGS: The fetal deaths. Well-conducted randomized controlled
median urinary iodine concentration significantly trials of adequate sample size and including
increased in women of child-bearing age from measures of effectiveness are needed in populations
<10 micrograms/L to 55 micrograms/L. Infant- at high risk of micronutrient deficiency and IUGR
mortality rates decreased in the treated areas of and should include food-based interventions and
Long Ru (mean [SD] 58.2 [4.4] per 1,000 births to better measurements of fetal growth, maternal
28.7 [7.1] per 1,000 births), Tusala (47.4 [12.4] metabolism, and long-term outcomes in the
per 1,000 births to 19.1 [1.5] per 1,000 births), offspring.
and Bakechi (106.2 [9.5] per 1,000 births to
57.3 [7.3] per 1,000 births). Similar results were
Gulmezoglu, A. M. and G. J. Hofmeyr. 2000.
also seen for neonatal mortality. On regression
“Maternal nutrient supplementation for
analysis iodine treatment and time were significant
suspected impaired fetal growth,” Cochrane.
independent predictors of infant mortality.
Database. Syst. Rev. no. 2, p. CD000148.
INTERPRETATION: Iodine supplementation of
irrigation water in areas of severe iodine deficiency Abstract: BACKGROUND: One way of attempting
decreases neonatal and infant mortality. Iodine to improve fetal growth has been nutrient
replacement has probably been an important factor supplementation for the mother when fetal growth
in the national decrease in infant mortality in is impaired. Different nutrients such as
China. carbohydrates and amino acids have been
suggested as treatments for impaired fetal growth.
OBJECTIVES: The objective of this review was to
MATERNAL NUTRITION
Fall, C. H., C. S. Yajnik, S. Rao, A. A. Davies, N. assess the effects of nutrient administration for
Brown, and H. J. Farrant. 2003. suspected fetal growth impairment on fetal growth
“Micronutrients and fetal growth,” J. Nutr., and perinatal outcome. SEARCH STRATEGY: We
vol. 133, no. 5 Suppl 2, pp. 1747S–1756S. searched the Cochrane Pregnancy and Childbirth
Abstract: Fetal undernutrition affects large Group trials register and the Cochrane Controlled
numbers of infants in developing countries, with Trials Register. Date of last search: December
adverse consequences for their immediate survival 1999. SELECTION CRITERIA: Acceptably
and lifelong health. It manifests as intrauterine controlled trials of nutrient administration for
growth retardation (IUGR), defined as birthweight suspected impaired fetal growth compared to
45
placebo or no treatment. DATA COLLECTION control groups were 3.33 +/– 0.4 and
AND ANALYSIS: Trial quality was assessed. 3.08 +/– 0.3 kg, respectively. This difference,
MAIN RESULTS: Three studies involving which amounts to 8.1%, was statistically
121 women were included. They were small and/or significant (p<0.05). While the two groups of
had methodological limitations. No difference was newborns had equal breastfeeding duration,
detected in the number of small for gestational age heights and weights of newborns were significantly
infants whose mothers had received nutrients higher in the experimental group. This was also
compared to those who did not (relative risk for confirmed when compared to the NCHS figures.
calf blood extract 0.54, 95% confidence interval
(CI): 0.20 to 1.47; for glucose 1.11, 95% CI: 0.64
to 1.92; for galactose 0.78, 95% CI: 0.39 to 1.54). Katz, J., K. P. West, Jr., S. K. Khatry, E. K.
REVIEWER’S CONCLUSIONS: There is not Pradhan, S. C. LeClerq, P. Christian, L. S. Wu,
enough evidence to evaluate the use of nutrient R. K. Adhikari, S. R. Shrestha, and A. Sommer.
therapy for suspected impaired fetal growth. The 2000. “Maternal low-dose vitamin A or beta-
studies were too small to detect any rare adverse carotene supplementation has no effect on fetal
effects. loss and early infant mortality: a randomized
cluster trial in Nepal,” Am. J. Clin. Nutr.,
vol. 71, no. 6, pp. 1570–1576.
Kaseb, F., M. Kimiagar, M. Ghafarpoor, and N.
Abstract: BACKGROUND: The effect of vitamin A
Valaii. 2002. “Effect of traditional food
supplementation on the survival of infants aged
supplementation during pregnancy on maternal
<6 months is unclear. Because most infant deaths
weight gain and birthweight,” Int. J. Vitam.
occur in the first few months of life, maternal
Nutr. Res., vol. 72, no. 6, pp. 389–393.
supplementation may improve infant survival.
Abstract: The effects of supplementary traditional OBJECTIVES: The objective was to assess the
food on pregnant women were investigated in a effect of maternal vitamin A or beta-carotene
clinical trial in Islamshahr, a suburban area 35km supplementation on fetal loss and survival of
southwest of Tehran. The study comprised 53 infants <6 months of age. DESIGN: Married
healthy mothers who were neither addicts nor on women of reproductive age in 270 wards of Sarlahi
medication and were free from genetic disorders. district, Nepal, were eligible to participate. Wards
The pregnant mothers’ health was evaluated by were randomly assigned to have women receive
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
their weight gain, that of lactating mothers by weekly doses of 7,000 microg retinol equivalents as
breastmilk adequacy, and that of newborns by retinyl palmitate (vitamin A), 42mg all-trans-beta-
their weight at birth. The experimental group carotene, or placebo. Pregnancies were followed
received traditional food (rice-milk porridge, until miscarriage, stillbirth, maternal death, or live
lentils, pottage, cheese, yogurt, eggs, and milk with birth of one or more infants, who were followed
bread), supplying an extra 400kcal energy and through 24 weeks of age. RESULTS: A total of
15g protein from the fourth month of pregnancy 43,559 women were enrolled; 15,832 contributed
until childbirth. All subjects were weighed 17,373 pregnancies and 15,987 live born infants to
monthly. To ascertain breastmilk sufficiency, the the trial. The rate of fetal loss was 92.0/1,000
duration of exclusive breastfeeding and the growth pregnancies in the placebo group, comparable with
trend of infants were surveyed. The study showed rates in the vitamin A and beta-carotene groups,
the weight gain in the experimental and control which had relative risks of 1.06 (95% CI:
groups to be 11.0 +/– 2.9 and 8.5 +/– 3kg 0.91–1.25) and 1.03 (95% CI: 0.87–1.19),
respectively; the difference was 29.4% and respectively. The 24-week mortality rate was
statistically significant (p<0.02). The confounding 70.8/1,000 live births in the placebo group,
variables (energy and protein intake, age, height, comparable with rates in the vitamin A and beta-
BMI, age at first pregnancy, parity, last pregnancy carotene groups, which had relative risks of 1.05
spacing, number of children, number of (95% CI: 0.87–1.25) and 1.03 (95% CI:
miscarriages, duration of residence in the area, 0.86–1.22), respectively. CONCLUSIONS: Small
family size, education, housing, occupation of the weekly doses of vitamin A or beta-carotene given
mother or her husband) did not reveal any to women before conception, during pregnancy,
significant differences. Maternal weight gain was and through 24 weeks postpartum did not improve
higher in the experimental compared to the fetal or early infant survival in Nepal.
control group. Birthweights in experimental and
46
Klebanoff, M. A., P. H. Shiono, J. V. Selby, A. I. authors were contacted for additional information.
Trachtenberg, and B. I. Graubard. 1991. MAIN RESULTS: Thirteen trials were included.
“Anemia and spontaneous preterm birth,” Am. They were of variable quality. Balanced
J. Obstet. Gynecol., vol. 164, no. 1 Pt 1, protein/energy supplementation was associated
pp. 59–63. with modest increases in maternal weight gain
(weighted mean difference 17 grams per week,
Abstract: The association between anemia during
95% confidence interval 5–29 grams per week) and
pregnancy and spontaneous preterm birth was
fetal growth (birthweight increase, weighted mean
studied with a two-stage case-control design in a
difference 25 grams, 95% confidence interval
large, multiethnic cohort. Results of all
4–55 grams). The reduction in risk of small for
hematologic measurements were abstracted from
gestational birth was substantial, however (odds
the prenatal and delivery records of 1,706 of the
ratio 0. 64, 95% confidence interval 0.53–0.78).
26,901 women in the cohort. Among women
These effects did not appear to be greater in
delivered of infants at term, mean hematocrit value
undernourished women, nor did they seem to
was low during the early phase of the second
confer long term benefits to the child. No
trimester, stable until near term, then reached a
significant effects were detected on preterm birth,
maximum at 40 weeks’ gestation. The mean
but significant reductions in stillbirth and neonatal
hematocrit value of black women was consistently
death (based on only three trials) appear
lower than that of Asian, Mexican, and white
important. REVIEWER’S CONCLUSIONS:
women. Anemia (hematocrit value less than the
Balanced energy/protein supplementation improves
tenth percentile for ethnic group and duration of
fetal growth and may reduce the risk of fetal and
pregnancy) at any time during the second trimester
neonatal death. The evidence is insufficient to
was positively associated with subsequent
evaluate whether there are other potential benefits
spontaneous preterm birth (odds ratio, 1.9;
to pregnant women or their infants.
95% CI: 1.3–2.8). Compared with white
women, the odds ratios for preterm birth were
2.0 (95% CI: 1.6–2.4) for black, 1.2 (95% CI: Kramer, M. S. 2000. “Nutritional advice in
0.9–1.6) for Asian, and 1.2 (95% CI: 1.0–1.5) for pregnancy,” Cochrane. Database. Syst. Rev.,
Mexican women. Adjustment for second-trimester no. 2, p. CD000149.
anemia had minimal influence on the odds ratios.
We conclude that anemia during the second Abstract: OBJECTIVES: To assess the effects of
trimester was associated with preterm birth. advising pregnant women to increase their energy
However, it does not account for the large ethnic and protein intakes on those intakes, on gestational
differences in preterm birth. weight gain, and on the outcome of pregnancy.
SEARCH STRATEGY: The register of clinical trials
maintained and updated by the Cochrane
Kramer, M. S. 2000. “Balanced protein/energy Pregnancy and Childbirth Group. SELECTION
supplementation in pregnancy,” Cochrane. CRITERIA: All acceptably controlled comparisons
Database. Syst. Rev., no. 2, p. CD000032. of nutritional advice, whether administered on a
one-to-one basis or to groups of women. DATA
Abstract: BACKGROUND: Observational and
COLLECTION AND ANALYSIS: Data were
non-randomized studies have suggested that
extracted by the author from published reports,
energy/protein supplementation in pregnant women
and supplemented by additional information from
increases gestational weight gain and fetal growth.
trialists contacted by the author. MAIN RESULTS:
OBJECTIVES: The objective of this review was to
Four trials involving 1,108 women were included.
assess the effects of a balanced protein/energy
Advice to increase energy and protein intakes
supplement for pregnant women on gestational
seems to be successful in achieving those goals, but
weight gain and on the outcome of pregnancy.
the increases are lower than those reported in trials
MATERNAL NUTRITION
47
One trial found no reduction in the incidence of Lechtig, A., R. E. Klein, D. C. Hernan, M. S. Read,
pre-eclampsia. No data have been reported on and S. G. Kahn. 1982. “Effects of maternal
potential adverse effects that might accompany nutrition on infant health: implications for
increased fetal size, such as an increased risk of action. Report of an International Workshop,
prolonged labor or cesarean section. REVIEWER’S Panajachel, Guatemala, March 12–16, 1979,” J.
CONCLUSIONS: Nutritional advice appears Trop. Pediatr., vol. 28, no. 6, pp. 273–286.
effective in increasing pregnant women’s energy
Abstract: Report of a 1979 workshop held in
and protein intakes, but the implications for fetal,
Guatemala to review findings on the relationship of
infant, or maternal health cannot be judged from
maternal nutrition to subsequent infant health and
the available trials. Given the rather modest health
survival. The information presented is examined in
benefits demonstrated with actual protein/energy
light of then current services designed to enhance
supplementation (see the Cochrane review of
maternal and child health through improved
“Balanced protein/energy supplementation in
nutrition. Three working groups were formed to
pregnancy”), however, the provision of such advice
deal with selected aspects of the problem. Research
is unlikely to be of major importance.
findings, current practices and policy implications
are analyzed in detail. Recently completed maternal
Kusin, J. A., S. Kardjati, J. M. Houtkooper, and U. nutrition intervention surveys indicate that
H. Renqvist. 1992. “Energy supplementation supplementation increases newborn birthweight,
during pregnancy and postnatal growth,” and that this effect is greatest when
Lancet, vol. 340, no. 8820, pp. 623–626. supplementation is provided in the third trimester
of pregnancy. Data from several of the studies
Abstract: The effect of improving maternal suggest that increased birthweight may have
nutrition during pregnancy on growth of the child beneficial effects on perinatal and infant mortality
has not been assessed, since previous studies levels and on subsequent child development. Since
supplemented the diets of children as well as a large proportion of reproductive age women in
mothers. In a controlled randomized trial in developing countries are malnourished, this
Madura, East Java, pregnant women received a knowledge should give added impetus to maternal
high (HE) or low (LE) energy supplement that nutrition schemes. Care must be taken, however, to
provided 1,950kJ (465kcal) or 218kJ (52kcal), clearly establish a target group, rather than
respectively, in the last trimester of pregnancy. The assuming uniform need in planning and
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
effect of this intervention on the children’s growth implementing programs of remediation. Available
was assessed longitudinally for the first five years research, along with easily conducted community
of life. Only the children of mothers who had surveys can be valuable in identifying need groups.
complied for at least 90 days were included. Community and government commitment and
Infants entered the study at birth and their growth cooperation, as well as self help represent essential
was measured at four-week intervals until 12 inputs, and this should be kept firmly in mind
months old; thereafter they were measured every during program planning and implementation.
three months. Growth curves were calculated from
a mathematical model, based on the best fit of
actual measurements and the age-related growth Li, D. K., J. R. Daling, B. A. Mueller, D. E.
velocity. Up to the age of 24 months, HE children Hickok, A. G. Fantel, and N. S. Weiss. 1995.
were significantly heavier than LE children (p less “Periconceptional multivitamin use in relation
than 0.05). HE children were also taller throughout to the risk of congenital urinary tract
the first five years (p less than 0.005 from 15 to anomalies,” Epidemiology, vol. 6, no. 3,
48 months, p<0.05 at both 3–12 and 60 months). pp. 212–218.
Weight-for-height by age was similar in both
Abstract: To study the relation of maternal
groups, but stunting (height-for-age) was less
periconceptional vitamin use to the risk of a
prevalent in HE children. In a community
congenital urinary tract anomaly (CUTA), we
characterized by chronic energy deficiency among
conducted a case-control study using the
women of reproductive age, energy
Washington State Birth Defect Registry. We
supplementation of women for the last 90 days of
identified CUTA cases with no known
pregnancy was effective in the promotion of
chromosomal abnormality in seven counties in
postnatal growth and reduction in malnutrition of
western Washington State occurring between
preschool children.
January 1, 1990, and December 31, 1991. We
randomly selected a sample, as controls, of all
48
infants delivered in five large hospitals in King Lumley, J., L. Watson, M. Watson, and C. Bower.
County who did not have a birth defect and who 2001. “Periconceptional supplementation with
were born in the same year as the cases. About folate and/or multivitamins for preventing
55% of all infants in King County and a smaller neural tube defects,” Cochrane. Database. Syst.
proportion of infants in the other six counties are Rev., no. 3, p. CD001056.
delivered in these five hospitals. We interviewed
Abstract: BACKGROUND: Neural tube defects
mothers of 118 cases and 369 controls to obtain
arise during the development of the brain and
information about their vitamin use during the
spinal cord. OBJECTIVES: The objective of this
pregnancy and during the year before the
review was to assess the effects of increased
conception. After adjustment for maternal race,
consumption of folate or multivitamins on the
family income, county of maternal residence, and
prevalence of neural tube defects periconceptionally
birth year, we found that women who used
(that is before pregnancy and in the first two
multivitamins during the first trimester had only
months of pregnancy). SEARCH STRATEGY: We
15% the risk of bearing a child with a CUTA
searched the Cochrane Pregnancy and Childbirth
compared with women who did not take vitamins
Group trials register. Date of last search: April
[odds ratio (OR)=0.15; 95% confidence interval
2001. SELECTION CRITERIA: Randomized and
(CI): 0.05–0.43]. The reduction was smaller for use
quasi-randomized trials comparing
restricted to the second or third trimesters
periconceptional supplementation by multivitamins
(OR=0.31; 95% CI: 0.09–1.02). Among women
with placebo, folate with placebo, or multivitamins
who used vitamins during the first trimester,
with folate; different dosages of multivitamins or
vitamin use before conception was not associated
folate; prepregnancy dietary advice and counseling
with any further reduction in the risk, nor did there
in primary care settings to increase the
appear to be an association with the amount or
consumption of folate-rich foods, or folate-fortified
brand of vitamin used.
foods, with standard care; increased intensity of
information provision with standard public health
Lu, Z. M., R. L. Goldenberg, S. P. Cliver, G. dissemination. DATA COLLECTION AND
Cutter, and M. Blankson. 1991. “The ANALYSIS: Two reviewers assessed trial quality
relationship between maternal hematocrit and and extracted data. MAIN RESULTS: Four trials of
pregnancy outcome,” Obstet. Gynecol., vol. 77, supplementation involving 6,425 women were
no. 2, pp. 190–194. included. The trials all addressed the question of
supplementation and they were of variable quality.
Abstract: The relationship between maternal Periconceptional folate supplementation reduced
hematocrit and pregnancy outcome at various the incidence of neural tube defects (relative
times in pregnancy was studied in 17,149 iron- and risk=0.28, 95% confidence interval: 0.13 to 0.58).
folate-supplemented pregnant women. On Folate supplementation did not significantly
univariate analysis, early-pregnancy hematocrits increase miscarriage, ectopic pregnancy or
below 37% were associated with preterm delivery. stillbirth, although there was a possible increase in
However, this relationship was not confirmed by multiple gestation. Multivitamins alone were not
multivariate analysis controlling for other risk associated with prevention of neural tube defects
factors. On both univariate and multivariate and did not produce additional preventive effects
analyses, both early and later in pregnancy, when given with folate. One dissemination trial, a
hematocrits above 40% were associated with community randomized trial, was identified
preterm delivery. In every gestational time period, involving six communities, matched in pairs, and
at least part of the excess of preterm births was where 1,206 women of child-bearing age were
explained by an increase in indicated preterm interviewed following the dissemination
deliveries. In both early and late pregnancy, and in intervention. This showed that the provision of
both the univariate and multivariate analyses, only
MATERNAL NUTRITION
49
throughout the health and education systems. maternal and perinatal mortality and morbidity.
Women whose fetuses or babies have neural tube OBJECTIVES: The objective of this review was to
defects should be advised of the risk of recurrence assess the effects of iron supplementation on
in a subsequent pregnancy and offered continuing hematological and biochemical parameters, and on
folate supplementation. The benefits and risks of pregnancy outcome. SEARCH STRATEGY: The
fortifying basic food stuffs, such as flour, with Cochrane Pregnancy and Childbirth Group trials
added folate remain unresolved. register was searched. Study authors were also
contacted. SELECTION CRITERIA: Acceptably
controlled trials of iron supplementation for
Mahomed, K. 2000. “Iron and folate pregnant women. DATA COLLECTION AND
supplementation in pregnancy,” Cochrane. ANALYSIS: Eligibility and trial quality were
Database. Syst. Rev., no. 2, p. CD001135. assessed by one reviewer. Study authors were
Abstract: BACKGROUND: Anemia in pregnancy is contacted for additional information. MAIN
a major health problem in many developing RESULTS: Twenty trials were included. Iron
countries where nutritional deficiency, malaria and supplementation raised or maintained the serum
other parasitic infections contribute to increased ferritin above 10 milligrams per liter. It resulted in
maternal and perinatal mortality and morbidity. a substantial reduction of women with a
OBJECTIVES: The objective of this review was to hemoglobin level below 10 or 10.5 grams in late
assess the effects of routine iron and folate pregnancy. Iron supplementation, however, had no
supplementation on hematological and biochemical detectable effect on any substantive measures of
parameters and on pregnancy outcome. SEARCH either maternal or fetal outcome. One trial, with
STRATEGY: The Cochrane Pregnancy and the largest number of participants of selective
Childbirth Group trials register was searched. versus routine supplementation, showed an
Study authors were also contacted. SELECTION increased likelihood of cesarean section and
CRITERIA: Acceptably controlled trials of routine postpartum blood transfusion, but a lower
iron and folate supplementation for pregnant perinatal mortality rate (up to seven days after
women. DATA COLLECTION AND ANALYSIS: birth). REVIEWER’S CONCLUSIONS: Iron
Eligibility and trial quality were assessed by one supplementation appears to prevent low
reviewer. Study authors were contacted for hemoglobin at birth or at six weeks postpartum.
additional information. MAIN RESULTS: Eight There is very little information on pregnancy
outcomes for either mother or baby. There are few
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
50
RESULTS: Three trials involving 1,551 women Abstract: A randomized double-blind prevention
were included. In two trials, iodine trial with a factorial design was conducted at
supplementation was associated with a statistically 33 centers in seven countries to determine whether
significant reduction in deaths during infancy and supplementation with folic acid (one of the
early childhood (relative risk=0.71, 95% vitamins in the B group) or a mixture of seven
confidence interval: 0.56 to 0.90). Iodine other vitamins (A, D, B1, B2, B6, C, and
supplementation was associated with decreased nicotinamide) around the time of conception can
prevalence of endemic cretinism at the age of four prevent neural tube defects (anencephaly, spina
years (relative risk=0.27, 95% confidence interval: bifida, encephalocele). A total of 1,817 women at
0.12 to 0.60) and better psychomotor development high risk of having a pregnancy with a neural tube
scores between 4 to 25 months of age. defect, because of a previous affected pregnancy,
REVIEWER’S CONCLUSIONS: Iodine were allocated at random to one of four groups—
supplementation in a population with high levels of namely, folic acid, other vitamins, both, or neither.
endemic cretinism results in an important reduction 1,195 had a completed pregnancy in which the
in the incidence of the condition with no apparent fetus or infant was known to have or not have a
adverse effects. neural tube defect; 27 of these had a known neural
tube defect, 6 in the folic acid groups and 21 in the
two other groups, a 72% protective effect (relative
Merialdi, M., L. E. Caulfield, N. Zavaleta, A. risk=0.28, 95% confidence interval: 0.12–0.71).
Figueroa, and J. A. DiPietro. 1999. “Adding The other vitamins showed no significant
zinc to prenatal iron and folate tablets improves protective effect (relative risk=0.80, 95% Cl:
fetal neurobehavioral development,” Am. J. 0.32–1.72). There was no demonstrable harm from
Obstet. Gynecol., vol. 180, no. 2 Pt 1, the folic acid supplementation, though the ability
pp. 483–490. of the study to detect rare or slight adverse effects
Abstract: OBJECTIVE: Our objective was to was limited. Folic acid supplementation starting
examine whether improvement in maternal zinc before pregnancy can now be firmly recommended
status during pregnancy is positively associated for all women who have had an affected
with fetal neurobehavioral development in a pregnancy, and public health measures should be
Peruvian population. STUDY DESIGN: We taken to ensure that the diet of all women who
electronically monitored, at 32 and 36 weeks’ may bear children contains an adequate amount of
gestation, 55 fetuses whose mothers were randomly folic acid.
assigned to receive, during pregnancy, a daily
supplement containing 60mg iron and 250mg
Myers, M. F., S. Li, A. Correa-Villasenor, Z. Li, C.
folate, with or without 15mg zinc. Fetal heart rate
A. Moore, S. X. Hong, and R. J. Berry. 2001.
and movement patterns were quantified in 55 and
“Folic acid supplementation and risk for
34 fetuses, respectively, as indexes of
imperforate anus in China,” Am. J. Epidemiol.,
neurobehavioral development. RESULTS: Fetuses
vol. 154, no. 11, pp. 1051–1056.
of mothers who received zinc supplementation
showed fewer episodes of minimal fetal heart rate Abstract: Maternal consumption of folic acid
variability, increased fetal heart rate range, an before pregnancy and during early pregnancy is
increased number of accelerations, an increased associated with a reduced risk for some birth
number of movement bouts, an increased amount defects. Whether folic acid can reduce the risk for
of time spent moving, and an increased number of imperforate anus is unknown. As part of a public
large movements. Differences by supplementation health campaign conducted in China from 1993
type increased with gestational age and were through 1995, the outcomes of pregnancies of > or
statistically significant at 36 weeks’ gestation = 20 weeks’ gestation were evaluated among
(P<.05). CONCLUSION: Improving maternal zinc women using folic acid supplements. The women
MATERNAL NUTRITION
status through prenatal supplementation may were asked to take one pill containing 400 microg
improve fetal neurobehavioral development. of folic acid (without other vitamins) every day
from the time of their premarital examination until
the end of their first trimester of pregnancy. Rates
MRC Vitamin Study Research Group. 1991. of imperforate anus and risk ratios for imperforate
“Prevention of neural tube defects: results of the anus among the offspring of these women were
Medical Research Council Vitamin Study. MRC calculated according to folic acid use. Among the
Vitamin Study Research Group,” Lancet, offspring of women who took folic acid and
vol. 338, no. 8760, pp. 131–137. women who did not take folic acid, 20 and
51
30 infants with imperforate anus were identified, Abstract: BACKGROUND: Infant malnutrition
respectively. The rate of imperforate anus was and mortality rates are high in less-developed
3.1 per 10,000 among the offspring of women who countries especially in low-birthweight infants.
did not take folic acid and 1.6 per 10,000 among Zinc deficiency is also widely prevalent in these
the offspring of women who took folic acid; circumstances. We aimed to assess the effect of
adjusted for maternal age, the risk ratio was daily zinc supplements given to pregnant mothers
0.59 (95% confidence interval: 0.33, 1.07). Daily on their infants’ growth and morbidity.
maternal consumption of 400 microg of folic acid METHODS: We did a double-blind, placebo
before and during early pregnancy may reduce the controlled, randomized trial in 199 and
risk for imperforate anus. 221 Bangladeshi infants whose mothers took 30mg
daily elemental zinc or placebo, respectively, from
12 to 16 weeks’ gestation until delivery. Infants
Osendarp, S. J., C. E. West, and R. E. Black. 2003. were followed up until six months of age. We
“The need for maternal zinc supplementation in obtained data for morbidity every week by
developing countries: an unresolved issue,” J. mothers’ recall. Infants’ anthropometric
Nutr., vol. 133, no. 3, pp. 817S–827S. measurements were done every month, and their
Abstract: Maternal zinc deficiency during serum zinc was assessed at one and six months of
pregnancy has been related to adverse pregnancy age. FINDINGS: Infants of mothers who received
outcomes. Most studies in which pregnant women zinc during pregnancy had at age six months
have been supplemented with zinc to examine reduced risks compared with those in the placebo
effects on pregnancy outcome have been carried group for acute diarrhea (risk ratio=0.84;
out in industrialized countries and the results have 95% CI: 0.72–0.98), dysentery (0.36; 0.25–0.84),
been inconclusive. This review discusses and impetigo (0.53; 0.34–0.82). These reductions
preliminary findings of eight randomized, were seen in low-birthweight infants but not in
controlled intervention trials performed recently in those with normal birthweight. There were no
less-developed countries. It is based on evidence differences in infant growth or serum zinc
presented by investigators and discussed during a concentrations between treatment groups.
workshop held in Wageningen, The Netherlands in INTERPRETATION: Maternal zinc
June 2001. Preliminary findings from these studies supplementation during pregnancy resulted in a
indicate maternal zinc supplementation has a reduction of the health risks in Bangladeshi low-
birthweight infants, although this intervention did
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
52
no detectable secular trends in the baseline data. concentration and birthweight as well as between
Supplementation was ineffective during the dry maternal hemoglobin concentration and preterm
season but highly effective during the wet season: birth. It was not possible to determine how much
+225 +/– 56g, p<0.001 (unadjusted) or +200 +/– of this association is attributable to iron-deficiency
53g, p<0.001 (adjusted for sex, season, and parity) anemia in particular. Minimal values for both low
by between-child multiple regression analysis; birthweight and preterm birth occurred at maternal
+231 +/– 65g, p<0.001 by within-mother analysis. hemoglobin concentrations below the current cut-
The proportion of low birthweight babies (less off value for anemia during pregnancy (110g/L) in
than 2,501g) decreased from 23.7%–7.5%, a number of studies, particularly those in which
p<0.002. The observed threshold effect emphasizes maternal hemoglobin values were not controlled
the importance of selective targeting of for the duration of gestation. Supplementation of
interventions to truly at-risk groups. anemic or nonanemic pregnant women with iron,
folic acid or both does not appear to increase either
birthweight or the duration of gestation. However,
Preziosi, P., A. Prual, P. Galan, H. Daouda, H. these studies must be interpreted cautiously
Boureima, and S. Hercberg. 1997. “Effect of because most are subject to a bias toward false-
iron supplementation on the iron status of negative findings. Thus, although there may be
pregnant women: consequences for newborns,” other reasons to offer women supplemental iron
Am. J. Clin. Nutr., vol. 66, no. 5, during pregnancy, the currently available evidence
pp. 1178–1182. from studies with designs appropriate to establish a
Abstract: We studied the effect of iron causal relationship is insufficient to support or
supplementation on the iron status of mothers and reject this practice for the specific purposes of
on biochemical iron status and clinical and raising birthweight or lowering the rate of preterm
anthropometric measures in their infants. The birth.
subjects were 197 pregnant women selected at
28 weeks +/– 21 days of gestation at a mother-and-
Roberts, S. B., A. A. Paul, T. J. Cole, and R. G.
child health center in Niamey, Niger. Ninety-nine
Whitehead. 1982. “Seasonal changes in activity,
women received 100mg elemental Fe/d throughout
birth weight and lactational performance in
the remainder of their pregnancies and 98 received
rural Gambian women,” Trans. R. Soc. Trop.
placebo. The prevalence of anemia and iron
Med. Hyg., vol. 76, no. 5, pp. 668–678.
deficiency decreased markedly during the last
trimester of pregnancy in the iron-supplemented Abstract: The activity of 81 pregnant, lactating and
group but remained constant in the placebo group. non-pregnant, non-lactating women in the rural
Three months after delivery, the prevalence of subsistence farming village of Keneba, The
anemia was significantly higher in the placebo Gambia, was measured for 12 months using a
group. At delivery, there were no differences combination of 24-hour activity recall and activity
between the two groups in cord blood iron diaries. During the course of pregnancy women
variables. Three months after delivery, serum became gradually less active and in the month
ferritin concentrations were significantly higher in before giving birth were 25% less active than non-
infants of women in the iron-supplemented group. pregnant, non-lactating women and lactating
Mean length and Apgar scores were significantly women when women in the month after birth were
higher in infants with mothers in the iron group excluded. There were striking seasonal changes in
than in those with mothers in the placebo group. activity. During the dry season, from January to
April, lactating women were active 55% of the
15-hour working day. At the start of the farming
Rasmussen, K. 2001. “Is There a Causal season in June and July this figure increased to
Relationship between Iron Deficiency or Iron- 92%. Similar changes were observed in the
MATERNAL NUTRITION
Deficiency Anemia and Weight at Birth, Length pregnant women whose activity increased from a
of Gestation and Perinatal Mortality?” J. Nutr., mean 50% in April to 83% in June. The period of
vol. 131, no. 2S-2, pp. 590S–601S. intense activity coincided with a general shortage
Abstract: An extensive literature review was of food and increased incidence of disease. The
conducted to identify whether iron deficiency, iron- intense activity of pregnant women in the farming
deficiency anemia and anemia from any cause are season coupled with the low food intakes are most
causally related to low birthweight, preterm birth probably the main factors responsible for the
or perinatal mortality. Strong evidence exists for an striking fall in birthweights observed at this time of
association between maternal hemoglobin the year. Reduced lactational performance was
53
apparent in relation to high activity when it gain) were no longer present. This reversal of risk
necessitated the mother regularly spending much of status may be attributable to the poor predictive
the day away from her child. FAO/WHO- value of anemia and iron deficiency tests during the
recommended energy intakes during pregnancy and third trimester. However, the relationship between
lactation are inappropriate for this community. poor diet (with inadequate iron intake) and
increased likelihood of preterm delivery persisted
during the third trimester.
Rouse, D. J. 2003. “Potential cost-effectiveness of
nutrition interventions to prevent adverse
pregnancy outcomes in the developing world,” Scholl, T. O. and W. G. Johnson. 2000. “Folic
J. Nutr., vol. 133, no. 5 Suppl 2, acid: influence on the outcome of pregnancy,”
pp. 1640S–1644S. Am. J. Clin. Nutr., vol. 71, no. 5 Suppl,
pp. 1295S–1303S.
Abstract: The potential cost-effectiveness of
antenatal nutrition interventions to improve Abstract: The periconceptional use of folic acid-
pregnancy outcomes in the developing world has containing supplements reduces the first
not undergone formal evaluation. Furthermore, the occurrence, as well as the recurrence, of neural
effectiveness of antenatal care in improving tube defects. Women of populations in which
maternal or fetal and neonatal health has been adverse pregnancy outcomes are prevalent often
questioned. However, reasonably compelling consume diets that contain a low density of
evidence from randomized trials shows that vitamins and minerals, including folate. Folate
nutrition interventions can prevent both infant intake may need to be sustained after complete
(iodine supplementation) and maternal (vitamin A closure of the neural tube to decrease the risk of
and beta-carotene supplementation) deaths, and other poor pregnancy outcomes. A central feature
informal analysis suggests that the cost- of embryonic and fetal development is widespread
effectiveness of nutrition interventions would be cell division; folate is central because of its role in
comparable and, in some cases, markedly superior nucleic acid synthesis. During gestation, marginal
to several standard antenatal interventions. Future folate nutriture can impair cellular growth and
efforts to establish the cost-effectiveness of replication in the fetus or placenta. Folate
nutrition interventions in developing countries will deficiency can occur because dietary folate intake is
depend on conducting large, pragmatic clinical low or because the metabolic requirement for
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
trials that use region- and resource-appropriate folate is increased by a particular genetic defect or
interventions with mortality or valid, defects. During pregnancy, low concentrations of
incontrovertibly severe morbidity endpoints. If such dietary and circulating folate are associated with
trials establish effectiveness, credible cost- increased risks of preterm delivery, infant low
effectiveness analyses can then be performed. birthweight, and fetal growth retardation. A
metabolic effect of folate deficiency is an elevation
of blood homocysteine. Likewise, the presence of
Scholl, T. O. and M. L. Hediger. 1994. “Anemia maternal homocysteine concentrations have been
and iron-deficiency anemia: compilation of data associated both with increased habitual
on pregnancy outcome,” Am. J. Clin. Nutr., spontaneous abortion and pregnancy complications
vol. 59, no. 2 Suppl, pp. 492S–500S. (e.g., placental abruption and preeclampsia), which
Abstract: Anemia diagnosed early in pregnancy is increase the risk of poor pregnancy outcome and of
associated with increased risks of low birthweight decreased birthweight and gestation duration.
and preterm delivery. In several studies, the
association between anemia and outcomes reversed
Scholl, T. O., M. L. Hediger, A. Bendich, J. I.
direction during the third trimester; maternal
Schall, W. K. Smith, and P. M. Krueger. 1997.
anemia was no longer a risk factor for poor
“Use of multivitamin/mineral prenatal
pregnancy outcomes. Camden study data were
supplements: influence on the outcome of
used to examine the probable cause of this
pregnancy,” Am. J. Epidemiol., vol. 146, no. 2,
observation. Maternal iron-deficiency anemia,
pp. 134–141.
diagnosed at entry to prenatal care, was associated
with low dietary energy and iron, inadequate Abstract: The objective of this study was to
gestational gain, and twofold or greater increases examine the association of prenatal
in the risks of preterm delivery and low multivitamin/mineral supplement use during the
birthweight. During the third trimester, these first and second trimesters of pregnancy by low
associations (except with inadequate gestational income, urban women in the Camden Study
54
(1985–1995, n=1,430) and preterm delivery (3.5%), however, was lower than anticipated for an
(<37 completed weeks) and infant low birthweight inner-city, minority population in whom most
(<2,500g). Prenatal supplement use was anemias had been attributed clinically to iron
corroborated by assay of circulating micronutrients deficiency.
at entry to care (no differences) and week
28 gestation (increased concentrations of folate and
ferritin for supplement users). Compared with Shaw, G. M. 2003. “Strenuous work, nutrition and
women who entered care during the first or second adverse pregnancy outcomes: a brief review,” J.
trimester but did not use prenatal supplements, Nutr., vol. 133, no. 5 Suppl 2,
supplement use starting in the first or second pp. 1718S–1721S.
trimester was associated with approximately a Abstract: This brief review explores the available
two-fold reduction in risk of preterm delivery. After epidemiologic data to investigate the question of
controlling for potential confounding variables, whether strenuous work by women during
risk of very preterm delivery (<33 weeks’ gestation) pregnancy in developing countries influences
was reduced more than fourfold for first trimester micronutrient status and thereby increase risks of
users and approximately two-fold when use dated adverse pregnancy outcomes. Some data exist on
from the second trimester. Infant low birthweight the potential relationship between strenuous work
and very low birthweight (<1,500g) risks were also or physical activity and nutrient compromise,
reduced. Risk of low birthweight was reduced strenuous work or physical activity and adverse
approximately two-fold with supplement use reproductive outcomes and micronutrient intakes
during the first and second trimester. Diminution in or status and adverse reproductive outcomes. No
risk was greater for very low birthweight infants, substantial body of data exists that has directly
amounting to a seven-fold reduction in risk of very investigated the potential causal path of whether
low birthweight with first trimester strenuous work during pregnancy alters
supplementation and a greater than six-fold micronutrient status leading to adverse
reduction when supplement use started in the reproductive outcome. Search of the literature
second trimester. Thus, in low income, urban identified only a few papers from developing
women, use of prenatal multivitamin/mineral countries that provided even remotely related data
supplements may have the potential to diminish on the topic. Thus, the available data are
infant morbidity and mortality. insufficient for drawing firm inferences that
strenuous work, in a developing country, alters a
pregnant woman’s nutritional status and therefore
Scholl, T. O., M. L. Hediger, R. L. Fischer, and J.
affects her risk of an adverse pregnancy outcome.
W. Shearer. 1992. “Anemia vs. iron deficiency:
Effects on nutritional status, micronutrients in
increased risk of preterm delivery in a
particular, of pregnant women from strenuous
prospective study,” Am. J. Clin. Nutr., vol. 55,
physical activities at work or in other lifestyle
no. 5, pp. 985–988.
events require further study in developing
Abstract: Using criteria from the Centers for countries.
Disease Control, anemia and iron-deficiency
anemia (anemia with serum ferritin concentrations
less than 12 micrograms/L) were assessed in greater Shaw, G. M., E. J. Lammer, C. R. Wasserman, C.
than 800 inner-city gravidas at entry to prenatal D. O’Malley, and M. M. Tolarova. 1995.
care. Iron-deficiency anemia was associated with “Risks of orofacial clefts in children born to
significantly lower energy and iron intakes early in women using multivitamins containing folic
pregnancy and a lower mean corpuscular volume. acid periconceptionally,” Lancet, vol. 346,
The odds of low birthweight were tripled and of no. 8972, pp. 393–396.
preterm delivery more than doubled with iron Abstract: Women are advised to take folic acid
MATERNAL NUTRITION
deficiency, but were not increased with anemia before they conceive as a precaution against neural-
from other causes. When vaginal bleeding at or tube defects. However, the use of folic acid in
before entry to care accompanied anemia, the odds preventing orofacial clefts is unknown. We
of a preterm delivery were increased fivefold for investigated whether a woman’s periconceptional
iron-deficiency anemia and doubled for other use of multivitamins containing folic acid was
anemias. Inadequate pregnancy weight gain was associated with a reduced risk of orofacial clefts.
more prevalent among those with iron-deficiency We derived data from a population-based case-
anemia and in those with anemias of other control study of fetuses and liveborn infants with
etiologies. The prevalence of iron-deficiency anemia orofacial anomalies among a 1987–89 cohort of
55
births in California. We interviewed 731 (84.7%) Suarez, L., K. A. Hendricks, S. P. Cooper, A. M.
of eligible mothers with orofacial cleft case infants Sweeney, R. J. Hardy, and R. D. Larsen. 2000.
and 734 (78.2%) mothers with non-malformed “Neural tube defects among Mexican
control infants. We found a reduced risk of Americans living on the US-Mexico border:
orofacial clefts if the mother had used effects of folic acid and dietary folate,” Am. J.
multivitamins containing folic acid during the Epidemiol., vol. 152, no. 11, pp. 1017–1023.
period from one month before through two months
Abstract: Populations of Mexican descent have
after conception. The odds ratios ranged from
high occurrences of neural tube defects (NTDs). A
0.50–0.73 depending on cleft phenotype.
recent study suggested that folic acid supplements
Controlling for the potential influence of other
may not protect these populations from NTDs. In
variables did not substantially alter the results.
a case-control study, the authors investigated the
Maternal daily consumption of cereal containing
role of folic acid and dietary folate intake in NTD
folic acid was also associated with a reduced risk
risk among Mexican Americans living along the
of orofacial clefts. Women who used multivitamins
Texas-Mexico border. From January 1995 to
containing folic acid periconceptionally had a
February 1999, 148 Mexican-American women
25%–50% reduction in risk for offspring with
with NTD-affected pregnancies and 158 women
orofacial clefts compared to women who did not
with normal live births were interviewed in person
use such vitamins. However, this association may
about use of vitamin supplements and dietary
not be attributable to folic acid specifically, but
intakes during a six-month periconceptional period
may be a consequence of other multivitamin
(from three months before conception to three
supplement components, or behaviors, that are
months after conception). Daily preconceptional
highly correlated with the use of multivitamins
consumption of vitamin supplements containing
containing folic acid.
folic acid was 2.5% in control women and 2.0% in
case women (odds ratio=0.77; 95% confidence
Steer, P. J. 2000, “Maternal hemoglobin interval (CI): 0.19, 3.22). With adjustment for
concentration and birth weight,” Am. J. Clin. maternal age, education, obesity, and previous
Nutr., vol. 71, no. 5 Suppl, pp. 1285S–1287S. stillbirth or miscarriage, the risk estimate was
essentially null (odds ratio=1.12; 95% CI: 0.22,
Abstract: Pregnancy requires additional maternal 5.78). Combined folic acid intake from diet and
absorption of iron. Maternal iron status cannot be supplements showed only a modest risk reduction
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
assessed simply from hemoglobin concentration for intakes of > or = 1.0mg per day (adjusted odds
because pregnancy produces increases in plasma ratio=0.73; 95% CI: 0.31, 1.72). The fact that the
volume and the hemoglobin concentration primary folic acid exposure was in the form of
decreases accordingly. This decrease is greatest in dietary polyglutamates rather than the more easily
women with large babies or multiple gestations. absorbed supplemental monoglutamates may
However, mean corpuscular volume does not explain an apparent decreased effect in this
change substantially during pregnancy and a population.
hemoglobin concentration <95g/L in association
with a mean corpuscular volume <84fL probably
indicates iron deficiency. Severe anemia Tafari, N., R. L. Naeye, and A. Gobezie. 1980.
(hemoglobin <80g/L) is associated with the birth of “Effects of maternal undernutrition and heavy
small babies (from both preterm labor and growth physical work during pregnancy on birth
restriction), but so is failure of the plasma volume weight,” Br. J. Obstet. Gynaecol., vol. 87,
to expand. Hemoglobin concentrations >120g/L at no. 3, pp. 222–226.
the end of the second trimester are associated with
Abstract: The study attempted to determine if
a </= three-fold increased risk of preeclampsia and
heavy physical labor by mothers during pregnancy
intrauterine growth restriction. The minimum
affected fetal growth when such mothers had
incidence of low birthweight (<2.5kg) and of
calorie intakes which were below 70% of
preterm labor (<37 completed weeks) occurs in
WHO/FAO recommended standards. Full-term
association with a hemoglobin concentration of
infants of such mothers had a mean birthweight of
95g/L–105g/L. This is widely regarded as
3,060g +/– 355(SD)g compared to 3,270g +/–
indicating anemia in the pregnant woman but, if
3,68(SD)g for the newborn of less physically active
associated with a mean corpuscular volume >84fL,
mothers on similar low calorie diets (P<0.01). The
should be considered optimal.
mothers who engaged in heavy labor had a mean
pregnancy weight gain of 3.3kg +/– 2.4(SD)kg,
56
independent of the birthweight of their offspring, supplementation, expressed either in continuous
compared with 5.9kg +/– 3.3kg for the less active fashion (total intake) or as caloric supplementation
mothers (P<0.001). The mothers’ weight in early per week. The adjusted mean birthweights of the
pregnancy had an insignificant influence on second offspring of women with high
birthweights when mothers were on low calorie supplementation during two pregnancies (about an
intakes. extra 180kcal/d), and the in-between lactation
period (about an extra 245kcal/d), were up to 301g
greater than that of the low supplementation
Underwood, B. A. 1994. “Maternal vitamin A group. Women with high supplementation while
status and its importance in infancy and early breastfeeding their first offsprings and during their
childhood,” Am. J. Clin. Nutr., vol. 59, no. 2 second pregnancies had babies up to 150g heavier
Suppl, pp. 517S–522S. than the reference group; those mothers with high
Abstract: Early fetal vitamin A supplies must be supplementation only during the second pregnancy
regulated to avoid teratogenic consequences from had infants about 124g heavier than those of the
too little or too much. Late in gestation, adequate low supplementation group. Therefore, high
maternal vitamin A status is important for supplementation during two consecutive
newborn reserves and for sustaining adequate pregnancies and their intervening lactation period
breastmilk concentrations. Vitamin A supplements among chronically, yet moderately, malnourished
are not needed for most pregnant women in women was capable of increasing the mean
Western countries who consume the recommended birthweight to levels closer to those reported for
dietary allowance during their reproductive years. industrialized populations. The mean birthweight
Increased consumption of vitamin A-rich foods can increase is between two and three times greater
meet increased needs during lactation. Women in than the effect shown in almost all of the previous
developing countries whose habitual intakes are studies of this topic.
near basal needs should receive an additional
100 micrograms retinol equivalents (RE) during
World Health Organization. 1998. Maternal
pregnancy and 300 micrograms RE during
nutrition and pregnancy outcomes.
lactation. Supplements not above 3,000
micrograms RE (10,000 IU) daily are safe for Abstract: A state-of-the-art report on the use of
fertile women where circumstances preclude simple, inexpensive anthropometric indicators to
obtaining the needed increment through diet. The measure the nutritional status of pregnant women,
first postpartum month is the only safe period predict pregnancy outcome, and identify women at
during which to provide deficient lactating women risk. Emphasis is placed on measurements and
with a single high-dose supplement to benefit the reference values that are simple and sensitive, have
mother and breastfeeding infant for several high predictive value, require inexpensive
months. equipment, and are suitable for immediate use in
settings where resources, equipment, and staff are
limited. Tools evaluated range from charts for
Villar, J. and J. Rivera. 1988. “Nutritional recording weight gain during pregnancy to a simple
supplementation during two consecutive band, made from used X-ray film, for measuring
pregnancies and the interim lactation period: arm circumference.
effect on birth weight,” Pediatr., vol. 81,
no. 1, pp. 51–57. PAHO Scientific Publication No. 529
PAHO 1991, ix + 214 pages [E; S from PAHO]
Abstract: The study consisted of 169 mothers ISBN 92 75 11529 X
enrolled during two consecutive pregnancies and
the intervening lactation period in the Guatemalan Available at:
Nutritional Supplementation Study. Women were http://www.who.int/dsa/cat98/mat8.htm
MATERNAL NUTRITION
57
occurrence of some birth defects other than neural Yip, R. 2002. “Iron supplementation: country level
tube defects. Using data from the population-based experiences and lessons learned,” J. Nutr.,
Atlanta Birth Defects Case-Control Study, we vol. 132, no. 4 Suppl, pp. 859S–861S.
investigated the possible association between
Abstract: Iron supplementation is a commonly used
periconceptional multivitamin use and the
strategy to meet the increased requirements of at-
occurrence of limb deficiency. We examined the
risk groups, such as women of childbearing age,
periconceptional use of multivitamins among
especially during pregnancy. Other at-risk groups
mothers of 117 babies with nonsyndromic limb
for which iron supplementation may be
deficiency who were liveborn or stillborn to
appropriate include infants, young children,
residents of metropolitan Atlanta from 1968 to
adolescents and the elderly. There is a need to
1980 and among mothers of 3,029 control babies
consider iron supplementation as part of a
born without birth defects who were randomly
comprehensive strategy for the prevention of iron
selected through birth certificates. We found that
deficiency, and not just as a treatment for anemia
children whose mothers were periconceptional
that is stopped as soon as clinical improvement is
multivitamin users had a lower risk of having a
noted. Experience in developing countries indicates
limb deficiency [odds ratio (OR)=0.47; 95%
that often the poorest women with the most
confidence interval (CI): 0.23–0.97]. This
deficient intakes are the least likely to receive iron
protective effect, however, was mostly seen for
supplements during pregnancy. Providing
transverse limb deficiency (OR=0.30; 95% CI:
supplements to women during antenatal care visits
0.07–1.32) and not for longitudinal deficiency
is useful but often inadequate, so other delivery
(including preaxial and postaxial deficiencies;
channels must also be explored, including private
OR=1.03; 95% CI: 0.17–4.30). Adjustment for
sector markets and community networks.
potential confounding factors did not change these
Communication efforts must be expanded to
findings. We found a trend of decreasing risk for
increase understanding of the importance of taking
all transverse limb deficiencies with earlier vitamin
supplements and to address any fears or
use. These data indicate that mothers’
misconceptions relating to supplementation.
periconceptional multivitamin use may reduce the
Overall, we must increase the capacity of
risk for some types of limb deficiency among their
individuals and communities to define, analyze and
offspring. In addition, because we did not find the
act to address their own health needs.
protective effect for all types of limb deficiency, the
data may also indicate causal heterogeneity of limb
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
deficiencies.
58
Maternal Infections
Brocklehurst, P. 2000. “Interventions for treating Library issue 1, 1999). SELECTION CRITERIA:
gonorrhoea in pregnancy,” Cochrane. Randomized trials of any antibiotic regimen
Database. Syst. Rev., no. 2, p. CD000098. compared with placebo or no treatment or
alternative antibiotic regimens in pregnant women
Abstract: BACKGROUND: Neisseria gonorrheae
with genital Chlamydia trachomatis infection.
can be transmitted from the mother’s genital tract
DATA COLLECTION AND ANALYSIS: Trial
to the newborn during birth and can cause
quality assessments and data extraction were done
gonococcal opthalmia neonatorum. OBJECTIVES:
independently by two reviewers. Study authors
The objective of this review was to assess the
were contacted for additional information. MAIN
effects of antibiotic regimens in the treatment of
RESULTS: Eleven trials were included. Trial quality
genital infection with gonorrhoea during pregnancy
was generally good. Amoxycillin appeared to be as
with respect to neonatal and maternal morbidity.
effective as erythromycin in achieving
SEARCH STRATEGY: The Cochrane Pregnancy
microbiological cure (odds ratio=0.54, 95%
and Childbirth Group trials register and the
confidence interval: 0.28 to 1.02). Amoxycillin was
Cochrane Controlled Trials Register were searched.
better tolerated than erythromycin (odds ratio=
Date of last search: October 1998. SELECTION
0.16, 95% confidence interval: 0.09 to 0.30).
CRITERIA: Randomized trials of one regimen of
Clindamycin and azithromycin also appear to be
antibiotic versus another in pregnant women with
effective, although the numbers of women included
culture confirmed genital gonococcal infection.
in trials are small. REVIEWER’S CONCLUSIONS:
DATA COLLECTION AND ANALYSIS: Eligibility
Amoxycillin appears to be an acceptable alternative
and trial quality were assessed by one reviewer.
therapy for the treatment of genital chlamydial
MAIN RESULTS: Two trials involving 329 women
infections in pregnancy when compared with
were included. Amoxycillin with probenicid or
erythromycin. Clindamycin and azithromycin may
spectinomycin or ceftriaxone have a similar effect
be considered if erythromycin and amoxycillin are
on microbiological cure, defined by negative
contra-indicated or not tolerated.
gonococcal culture. REVIEWER’S
CONCLUSIONS: Any of the antibiotic regimens
tested in these trials appear to be effective for the Brocklehurst, P., M. Hannah, and H. McDonald.
treatment of gonorrhea in pregnancy in terms of 2000. “Interventions for treating bacterial
their effect on microbiological cure. For women vaginosis in pregnancy,” Cochrane. Database.
who are allergic to penicillin, this review provides Syst. Rev., no. 2, p. CD000262.
reassurance that treatment with ceftriaxone or
spectinomycin appears to be at least as equally Abstract: BACKGROUND: Bacterial vaginosis has
effective in producing microbiological cure. been associated with poor perinatal outcome. Since
the infections are amenable to treatment,
identification during pregnancy and treatment may
Brocklehurst, P. and G. Rooney. 2000. reduce the risk of preterm birth and its
“Interventions for treating genital chlamydia consequences. OBJECTIVES: The objective of this
trachomatis infection in pregnancy,” Cochrane. review was to assess the effects of antibiotic
Database. Syst. Rev., no. 2, p. CD000054. treatment of bacterial vaginosis in pregnancy.
SEARCH STRATEGY: We searched the Cochrane
Abstract: BACKGROUND: Chlamydia trachomatis
Pregnancy and Childbirth Group trials register and
is a sexually transmitted infection. Mother-to-child
the Cochrane Controlled Trials Register.
MATERNAL INFECTIONS
59
trials involving 1,504 women were included. These country for which data were available, then for
trials were of good quality. Antibiotic therapy was each World Health Organization region, excluding
highly effective at eradicating infection during Europe. RESULTS: The estimated mean incidence
pregnancy as judged by “test-of-cure” following of CRS per 100,000 live births was lowest in the
therapy (odds ratio=0.22, 95% confidence interval: Eastern Mediterranean region (77.4, range 0–212)
0.17 to 0.27). The effect of treating bacterial and highest in the Americas (175, range 0–598).
vaginosis during pregnancy showed a trend to less The mean of the estimates of the total number of
births before 37 weeks’ gestation (odds ratio=0.78, cases of CRS in developing countries in 1996 was
95% confidence interval: 0.60 to 1.02). The approximately 110,000. The range was, however,
prevention of preterm birth less than 37 weeks’ very wide, from as few as 14,000 to as many as
gestation was most marked in the subgroup of 308,000 cases. CONCLUSIONS: Congenital
women with a previous preterm birth (odds ratio= rubella syndrome is an under-recognized public
0.37, 95% confidence interval: 0.23 to 0. 60). health problem in many developing countries.
REVIEWER’S CONCLUSIONS: The current There is an urgent need for collection of
evidence does not support screening and treating appropriate data to estimate the cost-effectiveness
all pregnant women for bacterial vaginosis to of a potential global rubella control program.
prevent preterm birth and its consequences. For
women with a history of a previous preterm birth
there is some suggestion that detection and Cutts, F. T., S. E. Robertson, J. L. Diaz-Ortega,
treatment of bacterial vaginosis early in pregnancy and R. Samuel. 1997. “Control of rubella and
may prevent a proportion of these women having a congenital rubella syndrome (CRS) in
further preterm birth. It is not known whether this developing countries, Part 1: Burden of disease
is associated with an improvement in neonatal from CRS,” Bull. World Health Organ.,
well-being. vol. 75, no. 1, pp. 55–68.
Abstract: Congenital rubella syndrome (CRS) can
lead to deafness, heart disease, and cataracts, and a
Cutts, F. T. and E. Vynnycky. 1999. “Modeling the
variety of other permanent manifestations. In
incidence of congenital rubella syndrome in
developing countries, the burden of CRS has been
developing countries,” Int. J. Epidemiol., vol.
assessed as follows: by surveillance of CRS; by
28, no. 6, pp. 1176–1184.
surveillance of acquired rubella; by age-stratified
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
Abstract: BACKGROUND: As of 1997, less than serosurveys; and by serosurveys documenting the
one-third of developing countries included rubella rubella susceptibility of women of childbearing age.
vaccine in their national immunization program. In During rubella outbreaks, rates of CRS per
countries that have achieved high coverage of 1,000 live births were at least 1.7 in Israel, 1.7 in
measles vaccine, an ideal opportunity exists to Jamaica, 0.7 in Oman, 2.2 in Panama, 1.5 in
include control of rubella and congenital rubella Singapore, 0.9 in Sri Lanka, and 0.6 in Trinidad
syndrome (CRS) in enhanced measles control and Tobago. These rates are similar to those
activities. Data on the burden of congenital rubella reported from industrialized countries during the
syndrome are important to guide rubella pre-vaccine era. Special studies of CRS have been
vaccination policies. METHODS: We reviewed the reported from all WHO regions. Rubella
literature to identify studies of rubella antibody surveillance data show that epidemics occur every
prevalence in developing countries that were four to seven years, similar to the situation in
conducted on populations with no major selection Europe during the pre-vaccination era. In
bias, prior to wide-scale rubella vaccination in the developing countries, the estimated average age at
country. We used a simple catalytic model to infection varies from two to three years to eight
describe the age-specific prevalence of susceptibility years. For 45 developing countries we identified
to rubella virus infection in given populations. serosurveys of women of childbearing age that had
Estimates of the incidence of infection among enrolled > or = 100 individuals. The proportion of
pregnant women were calculated using expressions women who remained susceptible to rubella (e.g.,
for the average prevalence of susceptibility to seronegative) was <10% in 13 countries,
infection and the incidence of infection during 10%–24% in 20 countries, and > or = 25% in 12
gestation. To estimate the number of cases of CRS, countries. Discussed are methods to improve the
we assumed an overall risk of 65% after infection surveillance of rubella and CRS in developing
in the first 16 weeks of pregnancy and zero risk countries.
thereafter. These estimates were derived for each
60
Czeizel, A. E., M. Rockenbauer, J. Olsen, and H. 3,461 multiparous women from a population with
T. Sorensen. 2001. “A population-based case- a high rate of congenital CMV infection who
control study of the safety of oral anti- delivered newborns screened for congenital CMV
tuberculosis drug treatment during pregnancy,” infection between 1993 and 1998, and whose cord
Int. J. Tuberc. Lung Dis., vol. 5, no. 6, serum specimen from a previous delivery could be
pp. 564–568. retrieved and tested for antibody to CMV. MAIN
OUTCOME MEASURE: Congenital CMV
Abstract: OBJECTIVE: To study the human
infection according to maternal immune status,
teratogenic potential of isoniazid and other anti-
age, race, parity, and socioeconomic status.
tuberculosis drug treatment during pregnancy.
RESULTS: Of 604 newborns born to initially
DESIGN AND SETTING: Cases from a large
seronegative mothers, congenital CMV infection
population-based dataset at the Hungarian Case-
occurred in 18 (3.0%). In contrast, of 2,857
Control Surveillance of Congenital Abnormalities,
newborns born to immune mothers, congenital
and controls from the National Birth Registry,
CMV infection occurred in 29 (1.0%) Two factors,
between 1980 and 1996. Information on all oral
preconception maternal immunity (adjusted risk
anti-tuberculosis drug treatments during pregnancy
ratio, 0.31; 95% confidence interval, 0.17–0.58)
was medically recorded. STUDY PARTICIPANTS:
and maternal age of 25 years or older (adjusted
Women who had newborns or fetuses with
risk ratio, 0.19; 95% confidence interval,
congenital abnormalities (case group), and women
0.07–0.49), were highly protective against
who had babies with no congenital abnormality
congenital CMV infection. No other factors were
(control group). MAIN OUTCOME MEASURES:
associated with a reduction in the risk of
Congenital abnormalities in newborn infants and
congenital CMV infection. CONCLUSION:
fetuses diagnosed prenatally during the second and
Naturally acquired immunity results in a
third trimesters, and postnatally from birth to the
69% reduction in the risk of congenital CMV
age of one year. RESULTS: Of 38,151 controls,
infection in future pregnancies.
29 (0.08%) were exposed to anti-tuberculosis drug
treatment during pregnancy; the corresponding
figures for cases were 22,865 and 11 (0.05%). The Goldenberg, R. L., W. W. Andrews, A. C. Yuan, H.
prevalence odds ratio was 0.6 (95% CI: 0.3–1.3). T. MacKay, and M. E. St Louis. 1997.
Analysis of isoniazid and other oral “Sexually transmitted diseases and adverse
antituberculosis drug use during the second and outcomes of pregnancy,” Clin. Perinatol,
third months of gestation, i.e., in the critical period vol. 24, no. 1, pp. 23–41.
for most major congenital abnormalities, in case-
control pairs did not indicate a teratogenic effect of Abstract: We emphasize again that the prevalence
these drugs in any group with congenital of maternal infections may vary in different
abnormality. CONCLUSION: Maternal exposure populations, and others might arrive at different
to oral anti-tuberculosis drugs during pregnancy estimates about the percentage of infants colonized
did not show a detectable teratogenic risk to the and, concerning those infants colonized, about the
fetus; however, the number of pregnant women percentage with adverse outcomes. Additionally,
who were treated with these drugs during the many women are colonized or infected
critical period of most major congenital simultaneously with several of the organisms
abnormalities was limited (6 cases vs. 21 controls). discussed in this review, and this may result in
different projections of morbidity and mortality
rates than those presented here. We realize also
Fowler, K. B., S. Stagno, and R. F. Pass. 2003. that new information is generated continually
“Maternal immunity and prevention of describing the relationship between various
congenital cytomegalovirus infection,” JAMA, maternal colonizations and preterm birth, and that
vol. 289, no. 8, pp. 1008–1011. screening and treatment protocols for several
MATERNAL INFECTIONS
61
done in this article. By comparing the effect of present without PROM, and 56.7% (51 of 90)
direct transmission of sexually transmitted when both chorioamnionitis and PROM were
organisms on adverse outcomes with the effect on present (P<.05). Only 27 of 333 cases of
overall outcome through an increase in the rate of histopathologic chorioamnionitis or 8.1% had
preterm births, we should be able to use this type maternal antepartum fever, and only 11 of 333 or
of analysis to establish some basis for allocation of 3.3% had neonatal sepsis. Using logistic regression
resources to future research as well as intervention analysis to control for confounding variables,
programs aimed at reducing sexually transmitted approximately 25% of the preterm deliveries were
disease-related adverse outcomes of pregnancy. statistically attributable to histopathologic
Finally, the appreciation of the effect of bacterial chorioamnionitis, occurring either alone or in
vaginosis on outcomes of pregnancy associated association with PROM. In light of the infrequency
with preterm birth gives bacterial vaginosis a with which histopathologic chorioamnionitis is
greater public health importance than has been clinically evident, the strong relationship between
attributed to it in the past as the subject of sexually histopathologic chorioamnionitis and preterm
transmitted disease research and prevention. delivery suggests that occult antepartum infection
of the genital tract is an important cause of
preterm delivery.
Guinness, L. F., S. Sibandze, E. McGrath, and A. L.
Cornelis. 1988. “Influence of antenatal
screening on perinatal mortality caused by Hauth, J. C., R. L. Goldenberg, W. W. Andrews,
syphilis in Swaziland,” Genitourin. Med., M. B. DuBard, and R. L. Copper. 1995.
vol. 64, no. 5, pp. 294-297. “Reduced incidence of preterm delivery with
metronidazole and erythromycin in women with
Abstract: In a survey of 283 deliveries in Swaziland,
bacterial vaginosis,” N. Engl. J. Med., vol. 333,
active syphilis (positive results in the Treponema
no. 26, pp. 1732–1736.
pallidum haemagglutination assay (TPHA) and the
rapid plasma reagin (RPR) test) was found in Abstract: BACKGROUND: Pregnant women with
37 (13.1%) and possibly active infection (positive bacterial vaginosis may be at increased risk for
TPHA but negative RPR test results) in a further preterm delivery. We investigated whether treatment
87 (30.7%). The perinatal mortality of untreated with metronidazole and erythromycin during the
mothers with active disease was 21.9% (7/32). The second trimester would lower the incidence of
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
RPR test carried out antenatally by nurses had a delivery before 37 weeks’ gestation. METHODS: In
sensitivity of 36% (13/36) and predictive accuracy 624 pregnant women at risk for delivering
of 48% (13/27). Awareness of this incidence of prematurely, vaginal and cervical cultures and other
syphilis led to improved antenatal clinic measures laboratory tests for bacterial vaginosis were
and the prophylactic treatment of all newborn performed at a mean of 22.9 weeks’ gestation. We
infants. More comprehensive serology is discussed then performed a 2:1 double-blind randomization
and the prophylactic treatment of mothers to treatment with metronidazole and erythromycin
considered. The need for health education aiming at (433 women) or placebo (191 women). After
safer sexual practices is of paramount importance in treatment, the vaginal and cervical tests were
a society facing the arrival of the human repeated and a second course of treatment was
immunodeficiency virus. given to women who had bacterial vaginosis at that
time (a mean of 27.6 weeks’ gestation). RESULTS:
A total of 178 women (29%) delivered infants at
Guzick, D. S. and K. Winn. 1985. “The association less than 37 weeks’ gestation. Eight women were
of chorioamnionitis with preterm delivery,” lost to follow-up. In the remaining population,
Obstet. Gynecol., vol. 65, no. 1, pp. 11–16. 110 of the 426 women assigned to metronidazole
Abstract: To ascertain what proportion of preterm and erythromycin (26%) delivered prematurely, as
deliveries are attributable to the association with compared with 68 of the 190 assigned to placebo
chorioamnionitis, the authors examined (36%, P=0.01). However, the association between
prospectively the placentas from all 2,774 women the study treatment and lower rates of prematurity
who delivered at the Johns Hopkins Hospital was observed only among the 258 women who had
during 1980. The incidence of preterm delivery was bacterial vaginosis (rate of preterm delivery,
5.4% (110 of 2,027) when neither 31% with treatment vs. 49% with placebo;
chorioamnionitis nor premature rupture of P=0.006). Of the 358 women who did not have
membranes (PROM) was present, bacterial vaginosis when initially examined, 22% of
11.9% (29 of 243) when chorioamnionitis was those assigned to metronidazole and erythromycin
62
and 25% of those assigned to placebo delivered delivery of a low birthweight infant was found
prematurely (P=0.55). The lower rate of preterm among those with both vaginal bacteroides and
delivery among the women with bacterial vaginosis Mycoplasma hominis (odds ratio, 2.1; 95%
who were assigned to the study treatment was confidence interval, 1.5 to 3.0). CONCLUSIONS.
observed both in women at risk because of previous Bacterial vaginosis was associated with the preterm
preterm delivery (preterm delivery in the treatment delivery of low birthweight infants independently
group, 39%; and in the placebo group, 57%; of other recognized risk factors.
P=0.02) and in women who weighed less than 50kg
before pregnancy (preterm delivery in the treatment
group, 14%; and in the placebo group, 33%; MMWR. 1998. 1998 Guidelines for Treatment of
P=0.04). CONCLUSIONS: Treatment with Sexually Transmitted Diseases.
metronidazole and erythromycin reduced rates of Abstract: These guidelines for the treatment of
premature delivery in women with bacterial patients who have sexually transmitted diseases
vaginosis and an increased risk for preterm delivery. (STDs) were developed by the CDC staff members
after consultation with a group of invited experts
who met in Atlanta on February 10–12, 1997. The
Hillier, S. L., R. P. Nugent, D. A. Eschenbach, M.
information in this report updates the
A. Krohn, R. S. Gibbs, D. H. Martin, M. F.
“1993 Sexually Transmitted Diseases Treatment
Cotch, R. Edelman, J. G. Pastorek, and A. V.
Guidelines.” Included are new recommendations
Rao. 1995. “Association between bacterial
for treatment of primary and recurrent genital
vaginosis and preterm delivery of a low-birth-
herpes and management of pelvic inflammatory
weight infant. The Vaginal Infections and
disease; a new patient-applied medication for
Prematurity Study Group,” N. Engl. J. Med.,
treatment of genital warts; and a revised approach
vol. 333, no. 26, pp. 1737–1742.
to the management of victims of sexual assault.
Abstract: BACKGROUND. Bacterial vaginosis is Revised sections describe the evaluation of
believed to be a risk factor for preterm delivery. We urethritis and the diagnostic evaluation of
undertook a study of the association between congenital syphilis. These guidelines also include
bacterial vaginosis and the preterm delivery of expanded sections concerning STDs among infants,
infants with low birthweight after accounting for children, and pregnant women and the
other known risk factors. METHODS. In this management of patients who have asymptomatic
cohort study, we enrolled 10,397 pregnant women human immunodeficiency virus infection, genital
from seven medical centers who had no known warts, and genital herpes. Guidelines are provided
medical risk factors for preterm delivery. At 23 to for vaccine-preventable STDs, including
26 weeks’ gestation, bacterial vaginosis was recommendations for the use of hepatitis A and
determined to be present or absent on the basis of hepatitis B vaccines.
the vaginal pH and the results of Gram’s staining.
Available at:
The principal outcome variable was the delivery at
http://www.cdc.gov/mmwr/PDF/RR/RR4701.pdf
less than 37 weeks’ gestation of an infant with a
birthweight below 2,500g. RESULTS. Bacterial
vaginosis was detected in 16% of the 10,397 Moyo, S. R., S. A. Tswana, L. Nystrom, S.
women. The women with bacterial vaginosis were Bergstrom, J. Blomberg, and A. Ljungh. 1995.
more likely to be unmarried, to be black, to have “Intrauterine death and infections during
low incomes, and to have previously delivered low pregnancy,” Int. J. Gynaecol. Obstet., vol. 51,
birthweight infants. In a multivariate analysis, the no. 3, pp. 211–218.
presence of bacterial vaginosis was related to
preterm delivery of a low birthweight infant (odds Abstract: OBJECTIVE: To elucidate whether
microbial infections are involved in the etiology of
MATERNAL INFECTIONS
were examined for clinical signs of syphilis. The develop acute pyelonephritis if asymptomatic
TPHA test result was reactive in 12.5% of bacteriuria is untreated. Asymptomatic bacteriuria
antenatal patients and in 42% of women who may have a role in preterm birth or it may be a
aborted in the later half of pregnancy. Among marker for low socioeconomic status which is
469 consecutive babies delivered at the hospital, associated with low birthweight. OBJECTIVES:
30 had reactive results to the TPHA test; of these The objective of this review was to assess the effect
two were stillborn and four had signs of congenital of antibiotic treatment for asymptomatic
syphilis at birth. Thus, syphilis appears to affect bacteriuria on persistent bacteriuria during
adversely an appreciably high number of pregnant pregnancy, the risk of preterm delivery, and the
women in Zambia. For this reason a special development of pyelonephritis. SEARCH
campaign to screen adequately and treat pregnant STRATEGY: I searched the Cochrane Pregnancy
women and neonates is needed. and Childbirth Group trials register. Date of last
search: December 2000. SELECTION CRITERIA:
Randomized trials comparing antibiotic treatment
Robertson, S. E., F. T. Cutts, R. Samuel, and J. L. with placebo or no treatment in pregnant women
Diaz-Ortega. 1997. “Control of rubella and with asymptomatic bacteriuria found on antenatal
congenital rubella syndrome (CRS) in screening. DATA COLLECTION AND ANALYSIS:
developing countries, Part 2: Vaccination Trial quality was assessed. MAIN RESULTS:
against rubella,” Bull. World Health Organ., Fourteen studies were included. Overall the study
vol. 75, no. 1, pp. 69–80. quality was not strong. Antibiotic treatment
Abstract: In 1995–1996 we conducted a review of compared to placebo or no treatment was effective
rubella immunization strategies. Worldwide, in clearing asymptomatic bacteriuria (odds ratio=
78 countries (more than one-third) reported a 0.07, 95% confidence interval: 0.05 to 0.10). The
national policy of using rubella vaccine. This was incidence of pyelonephritis was reduced (odds
closely related to country economic status. Based ratio=0.24, 95% confidence interval: 0.19 to 0.32).
on the United Nations country classification, Antibiotic treatment was also associated with a
64
reduction in the incidence of preterm delivery or 15% of 66 infants born to women with positive
low birthweight babies (odds ratio=0.60, RPR and FTA-ABS testing. CONCLUSION: These
95% confidence interval: 0.45 to 0.80). results indicate that a congenital syphilis
REVIEWER’S CONCLUSIONS: Antibiotic prevention program in Bolivia could substantially
treatment is effective in reducing the risk of reduce adverse infant outcomes due to this disease.
pyelonephritis in pregnancy. An apparent reduction
in preterm delivery is consistent with current
theories about the role of infection in preterm Steininger, C., M. Kundi, G. Jatzko, H. Kiss, A.
birth, but this association should be interpreted Lischka, and H. Holzmann. 2003. “Increased
with caution. risk of mother-to-infant transmission of
hepatitis C virus by intrapartum infantile
exposure to maternal blood,” J. Infect. Dis.,
Southwick, K. L., S. Blanco, A. Santander, M. vol. 187, no. 3, pp. 345–351.
Estenssoro, F. Torrico, G. Seoane, W. Brady, M.
Abstract: Virological and clinical data from
Fears, J. Lewis, V. Pope, J. Guarner, and W. C.
73 hepatitis C virus (HCV)-infected pregnant
Levine. 2001. “Maternal and congenital syphilis
women who gave birth to 75 children were merged
in Bolivia, 1996: prevalence and risk factors,”
retrospectively, by logistic regression analysis, to
Bull. World Health Organ., vol. 79, no. 1,
investigate risk factors for vertical transmission of
pp. 33–42.
HCV. Eighty-two percent of the HCV-infected
Abstract: OBJECTIVES: The present study was mothers were HCV-RNA-positive during
carried out in seven maternity hospitals to pregnancy, and 10% were coinfected with human
determine the prevalence of maternal syphilis at the immunodeficiency virus (HIV). Nine children were
time of delivery and the associated risk factors, to HCV infected, one was HIV infected, but none was
conduct a pilot project of rapid syphilis testing in HIV-HCV coinfected. Among vaginal deliveries, the
hospital laboratories, to assure the quality of mean HCV load of mothers who transmitted HCV
syphilis testing, and to determine the rate of to their infants was higher than that of those who
congenital syphilis in infants born to women with did not (8.1 x 10(5) vs. 1.4 x 10(4) copies/mL;
syphilis at the time of delivery—all of which would P=.056). A reduction in umbilical cord-blood pH
provide baseline data for a national prevention (relative risk, 3.9; P=.04) or the occurrence of
program in Bolivia. METHODS: All women perineal or vaginal laceration (relative risk, 6.4;
delivering either live-born or stillborn infants in the P=.028) during vaginal delivery significantly
seven participating hospitals in and around La Paz, increased the risk of vertical HCV transmission. In
El Alto, and Cochabamba between June and conclusion, high maternal viremia, infantile
November 1996 were eligible for enrollment in the hypoxia, and intrapartum exposure to virus-
study. FINDINGS: A total of 61 out of contaminated maternal blood increased the risk of
1,428 mothers (4.3%) of live-born infants and HCV transmission during vaginal deliveries.
11 out of 43 mothers (26%) of stillborn infants Consequently, cesarean section may reduce the risk
were found to have syphilis at delivery. of vertical HCV transmission in selected cases.
Multivariate analysis showed that women with
live-born infants who had less than secondary-level
education, who did not watch television during the Urrutia, J. J., L. J. Mata, F. Trent, J. R. Cruz, E.
week before delivery (this was used as an indicator Villatoro, and R. E. Alexander. 1975. “Infection
of socioeconomic status), who had a previous and low birth weight in a developing country. A
history of syphilis, or who had more than one study in an Indian village of Guatemala,” Am.
partner during the pregnancy were at increased risk J. Dis. Child, vol. 129, no. 5, pp. 558–561.
of syphilis. While 76% of the study population had Abstract: Infection of the pregnant woman may
received prenatal care, only 17% had syphilis
MATERNAL INFECTIONS
65
mortality throughout the world. It does not seem they received penicillin anti-syphilis treatment or
to be affected by the mother’s social class. not during pregnancy. RESULTS: The total number
Likewise, vaginal colonization with T-strain of of deliveries in the two hospitals during that period
Mycoplasma, Listeria monocytogenes, HVH type was 18,701, and 61 out of 9,805 women screened
2, and CMV has been associated with low for syphilis were positive, giving an incidence of
birthweight and fetal wastage. On the other hand, 6.2/1,000. The perinatal mortality rates were
data relating such common diseases as upper- 11.2% in treated group and 83.3% in untreated
respiratory tract infections and diarrhea, which are group, and incidences of congenital syphilis were
highly prevalent among the rural women we 17.6% and 72.7%, respectively. CONCLUSION:
studied, and fetal survival and well being are Syphilis in pregnancy is a serious complication to
lacking. However, in view of the high incidence of harm the fetus. Screening for syphilis during
stillbirths, prematurity, and fetal growth pregnancy is necessary. Penicillin treatment is
retardation in the Indian village we studied, it is effective and may reduce the perinatal mortality
reasonable to suspect causal influence of the highly rate and births of babies with congenital syphilis.
prevalent maternal infections. There is a great need
for a precise assessment of this problem. Our
prospective study, designed to answer this question, Zonneveld, M., A. B. Nunen, H. G. Niesters, R. A.
is in progress. Man, S. W. Schalm, and H. L. Janssen. 2003.
“Lamivudine treatment during pregnancy to
prevent perinatal transmission of hepatitis B
World Health Organization. 2000. Preventing virus infection,” J. Viral Hepat., vol. 10, no. 4,
Congenital Rubella Syndrome: Immunization pp. 294–297.
Strategies, Surveillance Needs. Report of a
Abstract: Vertical transmission of hepatitis B virus
Meeting.
(HBV) can occur occasionally despite vaccination
Abstract: A meeting on Prevention Congenital of the child. This vaccination breakthrough has
Rubella Syndrome (CRS): Immunization Strategies, been associated with high maternal viremia. We
Surveillance Needs, was held in Geneva 12–14 treated eight highly viremic (HBV-DNA >/=
January 2000. The meeting was organized by the 1.2 x 109geq/mL) mothers with 150mg of
WHO Department of Vaccines and Biologicals lamivudine daily during the last month of
(VandB), with financial support from the US pregnancy. HBV-DNA, hepatitis B surface antigen
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
Centers for Disease Control and Prevention and the (HBsAg), anti-HBs and anti-HBc of their offspring
March of Dimes Birth Defects Foundation. This were measured at birth and at 3, 6 and 12 months,
was the first international meeting on CRS and respectively. Twenty-four children, born to
rubella since 1984. untreated HBsAg-positive mothers with HBV-DNA
levels >/= 1.2 x 109geq/mL served as historical
Available at: http://www.who.int/vaccines-
controls. All children received passive-active
documents/DocsPDF00/www508.pdf
immunization at birth and were followed-up for
12 months. In the lamivudine group one of the
Xu, Y., X. Lu, and Y. Ling. 2001. “Treatment of eight children (12.5%) was still HBsAg and HBV-
syphilis in pregnancy and its perinatal DNA positive at the age of 12 months. All other
prognosis,” Zhonghua Fu Chan Ke. Za Zhi., children seroconverted to anti-HBs and maintained
vol. 36, no. 8, pp. 460–461. seroprotection. In three children, HBV-DNA was
temporarily detected by polymerase chain reaction.
Abstract: OBJECTIVE: To investigate the effects of In the untreated historical control group, perinatal
treatment of syphilis in pregnancy on perinatal transmission occurred in 7 of 25 children (28%).
prognosis. METHODS: Patients of syphilis in In highly viremic HBsAg-positive mothers,
pregnancy from Hainan Provincial People’s reduction of viremia by lamivudine therapy in the
Hospital and Haikou Municipal Maternal and last month of pregnancy may be an effective and
Child Health Center during 1995 to 2001 were safe measure to reduce the risk of child vaccination
collected for retrospective analysis. Pregnant breakthrough. This approach should be evaluated
women with syphilis were divided into treated in a large controlled trial.
group and untreated group according to whether
66
Prevention of Maternal and Neonatal Tetanus
Bennett, J., C. Breen, H. Traverso, S. B. Agha, J. neonates, and have documented that such
Macia, and J. Boring. 1999. “Circumcision and applications are a risk factor for neonatal tetanus
neonatal tetanus: disclosure of risk and its (NNT). In-use contamination of ghee with
reduction by topical antibiotics,” Int. J. Clostridium tetani has been demonstrated, but
Epidemiol., vol. 28, no. 2, pp. 263–266. mechanisms underlying the risk of ghee have been
incompletely evaluated epidemiologically.
Abstract: BACKGROUND: Previous case-control
METHODS: Detailed information on ghee usage,
studies have paradoxically suggested that
including fuels used to heat it, was obtained from
circumcisions protect against neonatal tetanus
cases of NNT (n=229) and their matched controls
(NNT), but these observations have not been
(n=687) from a population-based study of NNT in
adjusted for differences in the length of survival of
Punjab Province, Pakistan. Design variables were
cases and controls. METHODS: Boy cases (n=133)
created to evaluate the impact of different fuel
and their sex-matched controls (n=399) were
sources on risk of ghee applications. RESULTS:
extracted from a population-based study of NNT
Nearly one-third of all infants had ghee applied,
undertaken in Punjab Province, Pakistan. In the
and it was nearly always heated before application
resulting file, circumcisions were censored such
to umbilical wounds of newborns. After controlling
that analysis was restricted to only those that
for all factors found to be significantly associated
occurred before onset in cases or before age of
with NNT in conditional logistic regression, only
onset in the matched case for controls. The effect
ghee that had always been heated with dried cow
of topical antibiotics in circumcision wounds was
dung fuel was significantly associated with NNT.
then evaluated. RESULTS: After adjusting for
Topical antimicrobials and ghee were never applied
confounders, circumcision before onset posed a
together. CONCLUSIONS: Ghee applications to
significant risk for NNT (matched odds ratio
umbilical wounds, when heated with ‘clean’ fuels,
[OR]=3.1, 95% CI: 1.2–8.0). The risk of NNT in
appear to pose no increased risk of NNT, although
those circumcised before onset and treated with
handling practices undoubtedly result in hazardous
topical antibiotics did not differ significantly from
microbial contamination. In contrast, ghee heated
the referent group who had not been circumcised
with dung fuel was significantly associated with
before onset (matched OR=1.1, 95% CI: 0.2–6.8),
NNT. The effective promotion of topical
whereas the lack of topical use was associated with
antimicrobials might help reduce ghee use, since
significant risk (matched OR=4.2, 95% CI:
67
delivery and during the first few days after delivery can derive from exposures of the umbilical wound
was highly protective in univariate testing (matched at any time during the first several days of life.
odds ratio=0.2 [95% confidence interval: Thus, clean cord care at delivery is not itself
0.11–0.64], P=0.003), and remained significantly sufficient to prevent NNT and control programs
protective when other delivery and cord care need to address post-delivery sources of NNT.
practices were controlled. In contrast, applying
nothing to the wound was risky compared with
antimicrobial exposures. Hand washing and Black, R. E., D. H. Huber, and G. T. Curlin. 1980.
delivery by a trained birth attendant appeared “Reduction of neonatal tetanus by mass
protective. Application of animal dung or ash to immunization of non-pregnant women:
the umbilical wound was hazardous. Similarly, duration of protection provided by one or two
predelivery cutaneous or intravaginal exposure of doses of aluminium-adsorbed tetanus toxoid,”
mothers to ghee (clarified butter) and delivery on a Bull. World Health Organ., vol. 58, no. 6,
surface prepared with dried cow dung were risky, pp. 927–930.
with significant interaction noted between them. Abstract: The protection from neonatal tetanus
Mortality and NNT were far more likely among afforded by one to two doses of tetanus and
previous births to mothers of cases. diphtheria toxoids was determined by analyzing
CONCLUSIONS: Topical antimicrobials offer a neonatal mortality among infants born to the
new, effective and inexpensive means to prevent subjects 9–32 months after immunization in rural
NNT, and could usefully complement maternal Bangladesh. The neonatal mortality rate for
immunization with tetanus toxoid in controlling children whose mothers had received two injections
the disease. Special prevention efforts should be of tetanus toxoid was 20/1,000 births less than the
directed towards mothers of NNT cases. rate among children whose mothers had received
cholera toxoid, representing a 1/3 reduction in
neonatal mortality. The reduced mortality rate was
Bennett, J., M. Schooley, H. Traverso, S. B. Agha,
attributable almost entirely to a 75% lower death
and J. Boring. 1996. “Bundling, a newly
rate among infants 4–14 days of age. In the period
identified risk factor for neonatal tetanus:
up to 20 months after vaccination, the reduction in
implications for global control,” Int. J.
deaths among 4–14-day-old infants after a single
Epidemiol., vol. 25, no. 4, pp. 879–884.
dose of tetanus-diphtheria toxoids was about the
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
Abstract: BACKGROUND: Bundling, which same as that after two doses; however, beyond
consists of wrapping an infant for prolonged 20 months, a single dose did not appear to confer
periods in a sheepskin cover after dried cow dung protection. In countries with a high rate of
is applied, is a common and apparently unique neonatal tetanus and with little or no prenatal care,
practice limited to the rural, mountainous regions mass tetanus toxoid immunization of all women of
of Northern Pakistan. The practice is initiated at reproductive age may be indicated. The two initial
various ages during the neonatal period. Its immunizations can be spaced one year apart, if
potential contribution to neonatal tetanus (NNT) necessary, and booster doses should be scheduled
had not been evaluated. METHODS: A at subsequent three-year intervals.
population-based, matched, case-control study was
undertaken to assess bundling and other factors
potentially related to NNT in rural parts of the Boerma, J. T. and G. Stroh. 1993. “Using survey
Northern Areas, Pakistan. RESULTS: Bundling data to assess neonatal tetanus mortality levels
instituted within the first three days of life was a and trends in developing countries,”
substantial risk factor for NNT (odds ratio Demography, vol. 30, no. 3, pp. 459–475.
[OR]=2.5, 95% confidence interval [CI]: 1.3–4.9). Abstract: Demographic and health surveys are a
Other factors found risky for NNT were delivery useful source of information on the levels and
on a straw surface and pre-delivery intravaginal trends of neonatal mortality in developing
application of ghee to the mothers. Handwashing countries. Such surveys provide data on mortality
by the delivery attendant and use of a new razor to occurring at 4–14 days of life, which is a sensitive
cut the umbilical cord were protective. indicator of neonatal tetanus mortality. We analyze
CONCLUSIONS: Bundling is a significant risk birth history data from 37 national surveys in
factor for NNT in the mountainous regions of developing countries to assess the quality of
Northern Pakistan. While this practice is seemingly neonatal mortality data and to estimate levels and
limited to these remote areas, the findings have trends in mortality occurring at 4–14 days. It is
broad implications since they indicate that NNT shown that mortality at 4–14 days has declined
68
considerably during the last decade in most non-survivors succumbed after mean stay in the
developing countries, concomitant with hospital of 5.0 days. Mortality was significantly
development and expansion of programs to reduce associated with an incubation period of 6 days or
neonatal tetanus. These declines show that less (P=0.0026), infant’s weight of less than 2.5kg
reductions in neonatal tetanus mortality probably (P=0.0113), lack of antenatal care in a health
have been an important contributor to the decline facility (P=0.0279), birth at home (P=0.0455), but
of neonatal and infant mortality during the 1980s. not with lack of adequate maternal immunization
(P=0.2081; not significant). Multivariable analysis
showed that a short (< or = 6 days) incubation
Cotter, B., V. Bremer, G. Stroh, K. Msambichaka, period was the strongest predictor of mortality
E. Mabuzane, M. Munyoro, F. Shirehwa, R. (OR=3.11, P=0.0030) while low infant weight
Biellik, and M. Birmingham. 2003. (<2.5kg) was also a significant predictor (OR=2.46,
“Assessment of neonatal tetanus elimination in P=0.0408). CONCLUSIONS: Hygienic deliveries
an African setting by lot quality assurance and adequate cord care are very important for the
cluster sampling (LQA-CS),” Epidemiol. Infect., prevention of neonatal tetanus deaths, and
vol. 130, no. 2, pp. 221–226. universal prenatal care, including education
Abstract: Neonatal tetanus (NT) elimination, programs on appropriate perinatal and cord care,
<1 case per 1,000 live births (LB), was assessed at can significantly reduce NNT incidence and
district level in Zimbabwe using a combined lot mortality in developing countries.
quality assurance-cluster sampling survey (LQA-
CS). Three of the highest risk districts were
Deming, M. S., J. B. Roungou, M. Kristiansen, I.
selected. NT was considered eliminated if fewer
Heron, A. Yango, A. Guenengafo, and R.
than a specified number of NT deaths (proxy for
Ndamobissi. 2002. “Tetanus toxoid coverage as
NT cases) were found in the sample determined
an indicator of serological protection against
using operating characteristic curves and tables.
neonatal tetanus,” Bull. World Health Organ.,
TT2 + vaccine coverage was measured in mothers
vol. 80, no. 9, pp. 696–703.
who gave birth 1–13 months before the survey and
women aged 15–49 years. NT was considered as Abstract: OBJECTIVE: A Multiple-Indicator
eliminated, TT2+ coverage was 78% (95% CI: Cluster Survey (MICS) was conducted at mid-
71%–82%) in women aged 15–49 and 83% decade in more than 60 developing countries to
(95% CI: 76%–89%) in mothers. The survey cost measure progress towards the year 2000 World
U.S. $30,000 excluding costs of consultants. NT Summit for Children goals. These goals included
incidence was below the elimination threshold the protection of at least 90% of children against
(<1/1,000 LB) in the surveyed districts and neonatal tetanus through the immunization of their
immunogenic. Potential factors that may affect TT having some school education were independently
immunogenicity need to be evaluated if NT is to be associated with complete immunization.
eliminated and if non-NT is to be controlled. CONCLUSIONS: Immunization of pregnant
Although data are conflicting, concurrent malarial women with tetanus toxoid was the single most
infection may decrease the immune response to TT; effective intervention against neonatal tetanus
however, malarial chemoprophylaxis may enhance independent of other interventions.
the immune response. Malnutrition does not
appear to affect immunogenicity; nevertheless, one
study suggests that vitamin A deficiency is Gurkan, F., M. Bosnak, B. Dikici, V. Bosnak, M.
associated with an impaired immune response. A. Tas, K. Haspolat, I. H. Kara, and I Ozkan.
Although it has been postulated that placental 1999. “Neonatal tetanus: a continuing
transfer of tetanus antibody is impaired in African challenge in the southeast of Turkey: risk
women, a survey of the published literature factors, clinical features and prognostic
suggests that this is not the case. Freezing TT has factors,” Eur. J. Epidemiol., vol. 15, no. 2,
been shown to decrease its potency, but its impact pp. 171–174.
on immunogenicity needs more evaluation.
Abstract: Neonatal tetanus (NT) still causes
significant mortality in developing countries,
“Evaluation of neonatal tetanus elimination in although in 1989 WHO adopted the goal of
Rajastan, India,” 2003. Wkly. Epidemiol. Rec., eliminating the disease by 1995–2000. To
vol. 78, no. 5, pp. 25–32. characterize the regional characteristics, clinical
charts of 55 neonates (42 males and 13 females)
Abstract: Full text available at: admitted to the Pediatric Infectious Diseases Ward
http://www.who.int/wer/2003/wer7805.pdf of Dicle University Hospital, Diyarbakir, Turkey
with the diagnosis of NT from 1991 to 1997 were
70
reviewed. Mean age at admittance was 8.9 +/– 4.3 Most cases occurred as a result of the cultural
days with a range of 3–25 days. Mean period for practice of applying cow dung or rat feces to the
the appearance of first symptoms was 5.8 days umbilical stump in the neonatal period. Although
ranging between one and 21 days. Mean all districts met the WHO elimination target during
birthweight of the patients was 3,369 +/– 560g. All the review period, there is scope to prevent
patients were from rural areas and were delivered unnecessary NNT deaths through culturally
at home by untrained traditional birth attendants acceptable public awareness campaigns aimed at
with no prior antenatal healthcare services. Razor changing harmful practices, and encouraging
blade (55%), scissors (27%), and knife (18%) were hygienic births and postnatal cord care.
the instruments used to cut the cord in non-
hygienic conditions. No mothers had prior
vaccination with tetanus toxoid during their Kapoor, S. K., V. P. Reddaiah, and J. Lobo. 1991.
pregnancy. Spasticity (76%), lack of sucking “Control of tetanus neonatorum in a rural
(71%), trismus (60%), fever (49%), omphalitis area,” Indian J. Pediatr., vol. 58, no. 3,
(44%), irritability (24%), risus sardonicus (22%), pp. 341–344.
and opithotonus (15%) were the most common Abstract: Experience in the control of tetanus
presenting signs and symptoms. Age at admission neonatorum (TN) in a rural area is presented. TN
<7.5 days and symptoms of onset <4.9 days, risus was reduced by training of dais, increasing the
sardonicus and opisthotonus were associated with coverage of tetanus toxoid to pregnant women and
fatal outcome. All patients were treated with distribution of presterilized delivery kits to
human tetanus immunglobulin or equine tetanus pregnant ladies for use by birth attendants. The
antitoxin where available, antibiotic therapy by problems of untrained birth attendants,
penicillin G (100.000 U/kg/day) and intravenous effectiveness of tetanus toxoid coverage and place
high dose diazepam (40mg/kg/day). Overall of delivery are discussed.
mortality rate was 40% (22 cases), without any
equipment for mechanical ventilation. Health
education of mothers and birth attendants, Mansour, E., R. B. Aylward, and F. Cummings.
promotion of hospital delivery and prenatal tetanus 1997. “Integrated disease control initiatives:
immunization of all pregnant women particularly polio eradication and neonatal tetanus
in rural areas are recommended, if NT is to be elimination in Egypt,” J. Infect. Dis., vol. 175
prevented. Suppl 1, pp. S277–S280.
Abstract: Accelerated disease control initiatives,
Idema, C. D., B. N. Harris, G. A. Ogunbanjo, and such as polio eradication by the year 2000, may
71
Meegan, M. E., R. M. Conroy, S. O. Lengeny, K. Family Planning and comparison areas during the
Renhault, and J. Nyangole. 2001. “Effect on September 1, 1978 until December 31, 1979 period
neonatal tetanus mortality after a culturally- were identified. These records were linked with any
based health promotion program,” Lancet, deaths recorded within 28 days of birth. The
vol. 358, no. 9282, pp. 640–641. acceptance of tetanus vaccination during the 1974
cholera vaccine trial, by the mothers of these live
Abstract: The Maasai have high rates of death
births, was ascertained from the 1974 vaccine
from neonatal tetanus, partly due to their custom
registers. The acceptance of vaccination during the
of packing the umbilical stump with cow dung. We
1978–1979 program was obtained from the field
report on the effect of a simple health promotion
registers. For infants whose mothers had received
program, designed in consultation with the local
two tetanus injections 48–64 months prior to
community and carried out by local women. After
delivery, the neonatal mortality rate was 63.8/l,000
introduction of the program in 1981, neonatal
live births compared with 78.3/1,000 for infants
(<6 weeks of age) tetanus rates fell sharply, and by
whose mothers did not receive tetanus
1988 annual death rates had dropped to 0.75
immunization. Immunization of women with two
(range 0–3) per 1,000 births in the intervention
tetanus injections during pregnancy reduced
areas compared with 82 (74–93) per 1,000 in
neonatal mortality rates to 42.8/1,000, a reduction
control areas.
of 35.5/1,000. Mortality on days 4–14 was reduced
by about 70%. One injection during pregnancy did
Rahman, M., L. C. Chen, J. Chakraborty, M. not appear to provide protection against tetanus
Yunus, A. I. Chowdhury, A. M. Sarder, S. neonatorum.
Bhatia, and G. T. Curlin. 1982. “Use of tetanus
toxoid for the prevention of neonatal tetanus. 1.
Schofield, F. 1986. “Selective primary health care:
Reduction of neonatal mortality by
strategies for control of disease in the
immunization of non-pregnant and pregnant
developing world. XXII. Tetanus: a preventable
women in rural Bangladesh,” Bull. World
problem,” Rev. Infect. Dis., vol. 8, no. 1,
Health Organ., vol. 60, no. 2, pp. 261–267.
pp. 144–156.
Abstract: One approach to the prevention of
Abstract: Tetanus, although an eminently
tetanus neonatorum (a leading cause of infant
preventable disease, remains common and
death throughout the world) is improving the
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
72
incidence of neonatal tetanus would provide a achieved, maintaining it. They are intended for
good indicator of the degree of effectiveness such public health managers at the national and district
services have attained in many rural communities. levels in countries that have not yet reached the
goal and for the organizations that provide them
with technical assistance. They will also be useful
Steinglass, R., L. Brenzel, and A. Percy. 1993. for development partners that are planning
“Tetanus,” in Disease Control Priorities in financial or other support.
Developing Countries, Oxford University Press.
Available at:
http://www.unicef.org/program/health/document/m
Traverso, H. P., S. Kamil, H. Rahim, A. R. Samadi, nt_eng.pdf
J. R. Boring, and J. V. Bennett. 1991. “A
reassessment of risk factors for neonatal
tetanus,” Bull. World Health Organ., vol. 69, Yaramis, A. and M. A. Tas. 2000. “Neonatal
no. 5, pp. 573–579. tetanus in the southeast of Turkey: risk factors,
and clinical and prognostic aspects. Review of
Abstract: A hospital-based case-control study was 73 cases, 1990–1999,” Turk. J. Pediatr.,
conducted to further examine the risk factors for vol. 42, no. 4, pp. 272–274.
neonatal tetanus (NNT) in the North-west Frontier
Province of Pakistan. Three control infants were Abstract: Although neonatal tetanus (NT) can be
concurrently evaluated for each of prevented by immunization of expectant mothers
102 consecutively diagnosed NNT cases and by good hygiene and asepsis during delivery, it
hospitalized over an eight-week period. Application is still a common cause of neonatal mortality in
of clarified butter (ghee) during the first few days developing countries. The objective of this study
of life was shown to be a significant risk factor, was to determine indicators in NT. We reviewed
confirming our previously reported finding. the clinical records of 73 neonates admitted to the
However, the risk appeared to be limited to ghee Pediatric Infectious Diseases Ward of Dicle
made in the home from cow’s milk. The tool used University Hospital, Diyarbakir, Turkey, with the
to cut the umbilical cord was again refuted to be a diagnosis of NT. Delivery had occurred at home by
risk factor; application of topical antibiotics untrained traditional birth attendants in all cases.
conferred significant protection. Multivariate None of the mothers had immunization with
analysis of the matched data showed that delivery tetanus toxoid during pregnancy. The median age
by persons with academic training (physicians, of infants at presentation was 7.3 days and the
nurses, and lady health visitors) was also mean age at onset of symptoms was 5.6 +/– 2.8
protective. Mothers with a past history of NNT days. The overall mortality was found to be 52%.
73
Malaria in Pregnancy and Impact on the Newborn
Infant
Akindele, J. A., A. Sowunmi, and A. E. sequester in the intervillous space of infected
Abohweyere. 1993. “Congenital malaria in a placentas. In subsequent pregnancies, women are
hyperendemic area: a preliminary study,” Ann. protected from maternal malaria through
Trop. Paediatr., vol. 13, no. 3, pp. 273–276. antibodies that prevent cytoadhesion of P.
falciparum-infected erythrocytes in the placenta.
Abstract: The prevalence of Plasmodium
Here, we summarize our current knowledge of the
falciparum parasitemia was evaluated in
pathophysiological processes underpinning
59 neonates admitted to the University College
maternal malaria and discuss emerging concepts
Hospital, Ibadan in South-western Nigeria between
for intervention.
August and December 1991—a period spanning
part of both wet and dry seasons. Peripheral
parasitemia was present in 14 (23.7%) neonates; of Ayisi, J. G., A. M. van Eijk, F. O. ter Kuile, M. S.
these, 4 were preterm (4/26, 15%) and 10 were Kolczak, J. A. Otieno, A. O. Misore, P. A.
term babies (10/33, 30.3%). The difference in the Kager, R. W. Steketee, and B. L. Nahlen. 2003.
prevalence of P. falciparum parasitemia in the two “The effect of dual infection with HIV and
groups was not statistically significant (chi- malaria on pregnancy outcome in western
square=1.78; p=0.10). Parasite densities in all Kenya,” AIDS, vol. 17, no. 4, pp. 585–594.
neonates were uniformly low (<2,000 asexual
forms/microliters blood), and only four of the Abstract: OBJECTIVE: To determine the effect of
neonates had fever within 48 hours of birth. dual infection with HIV and malaria on birth
Infected neonates weighed 200g more than non- outcomes and maternal anemia among women
infected neonates, but the difference was not delivering at a large public hospital in Kisumu,
statistically significant. Maternal weekly western Kenya. SUBJECTS AND METHODS:
75
particular risk of adverse birth outcomes. In areas included 126 participants, who were offered
with a moderate or high prevalence of HIV and malaria prophylaxis with proguanil (200mg/day)
malaria, all pregnant women should be the focus of and chloroquine (300mg/week). The results show
malaria and anemia control efforts to improve that 1) infants of first and second pregnancies had
birth outcomes. lower birthweights (–382.7 +/– 62.6g; P<0.0001)
compared with higher rank pregnancies; 2) strong
seasonal variation in birthweight was observed in
Balaka, B., A. D. Agbere, P. Bonkoungou, P. Phase I, with an annual cycle, a nadir in January,
Kessie, K. Assimadi, and K. Agbo. 2000. and an amplitude of 372.4g (P=0.0002);
“Congenital malarial disease due to 3) parasitemia measured during pregnancy was
Plasmodium falciparum in high-infection-risk associated with lower birthweight in infants from
newborn,” Arch. Pediatr., vol. 7, no. 3, first and second pregnancies, but not from higher
pp. 243–248. parity mothers; and 4) malaria prophylaxis taken
Abstract: The aim of this work was to differentiate for 20 weeks or more in Phase II suppressed the
in an endemic area congenital malaria diseases seasonal variation of birthweight and the effect of
(CMD) from congenital malaria infestations (CMI) low parity (+423.4 +/– 118.8g; P=0.0004). We
or other maternal-fetal infections. METHODS: conclude that malaria in pregnancy has an
Four hundred and seventy-five newborn (0–7 days) important negative impact on birthweight in first
suspected of infection were prospectively studied. and second pregnancies. Prophylaxis with
CMD was diagnosed when clinical manifestations proguanil and chloroquine is an effective
were associated with positive thick and thin blood prophylaxis when taken for 20 weeks or more.
films in a mother and her newborn. The diagnosis
of CMI was retained when despite positive
Brabin, B. and C. Piper. 1997. “Anemia- and
parasitemia, no clinical manifestations were
malaria-attributable low birthweight in two
observed. RESULTS: Forty newborns (1.7% of the
populations in Papua New Guinea,” Ann. Hum.
cases of maternal malaria) were diagnosed as CMD
Biol., vol. 24, no. 6, pp. 547–555.
and 91 (19% of live births) were considered as
CMI. The main clinical manifestations were related Abstract: We studied 7,300 singleton births in the
to cerebral (100%), respiratory (95%), and highlands and 4,881 in coastal Papua New Guinea
hemodynamic (90%) systems. Hematologic signs in order to examine the separate contribution of
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
were present in 95% of cases. The level of anemia or malaria to low birthweight. The
parasitemia varied from 700 to 3,000 parasites/mL highland sample was selected from a non-
in CMD and from 360 to 870 parasites/mL in malarious area (Goroka) and the coastal sample
CMI. Death occurred in 10 cases (25%) of CMD. from an area with perennial malaria transmission
CONCLUSION: In this malaria-endemic area, (Madang). There was an approximately three-fold
neither clinical manifestions nor parasitemia allow increased risk of low birthweight (<2,500g) in live-
one to distinguish CMD from CMI associated with births in Madang compared to Goroka. The
bacterial materno-fetal infections. Studying prevalence of anemia in the two areas was
placental or systemic immunity and antimalaria strikingly different, with 29.2% of Goroka and
IgM in the newborn could be of interest to clarify 89.0% of Madang women anaemic. There was a
this problem. trend towards increased low birthweight with
decreasing hemoglobin levels in both areas, but this
was significant only for Madang. It was assumed
Bouvier, P., N. Breslow, O. Doumbo, C. F. Robert, that for a given hemoglobin level the increased low
M. Picquet, A. Mauris, A. Dolo, H. K. birthweight percentage in Madang compared to
Dembele, V. Delley, and A. Rougemont. 1997. Goroka was due to malaria exposure, and on this
“Seasonality, malaria, and impact of basis relative risk values were estimated for the
prophylaxis in a West African village. II. Effect effect of malaria exposure on low birthweight.
on birthweight,” Am. J. Trop. Med. Hyg., Using this approach separate estimates for anemia
vol. 56, no. 4, pp. 384–389. and malaria population-attributable risk for low
Abstract: The impact of malaria on low birthweight in Madang were calculated. These
birthweight was investigated in Bougoula village indicated that up to 40% of low birthweight babies
(Sikasso region, Mali). In two successive years, born in malarious areas may be attributable to
pregnant women were followed until delivery. malaria and less than 10% attributable to severe
Phase I (1992) was observational, with anemia (Hb <7.0g dl–1). The magnitude of the
135 complete observations. Phase II (1993) malaria effect estimated in this analysis places a
76
high priority on malaria control in pregnancy as a treated group. It may also indicate that malaria is
strategy for improving birthweight and child only one of several risk factors responsible for
survival. LBW. The relatively small increase in birthweight,
the expected poor acceptance of mass prophylaxis,
and the spreading of chloroquine-resistant
Chimsuku, L., F. H. Verhoeff, S. M. Maxvell, R. L. Plasmodium strains should be considered before
Broadhead, A. Thomas, H. J. Van der Kaay, W. extending malaria chemoprophylaxis to all
Russell, and B. Brabin. 1994. “The pregnant women. It might be worth considering to
consequences of malaria infection in pregnant limit prophylaxis to primigravidae.
women and their infants,” Mem. Inst. Oswaldo
Cruz, vol. 89 Suppl 2, pp. 1–2.
D’Alessandro, U., P. Langerock, S. Bennett, N.
Abstract: Preliminary results are presented from
Francis, K. Cham, and B. M. Greenwood.
this study which indicate that 84.8% of pregnant
1996. “The impact of a national impregnated
women present at first antenatal visit with anemia
bed net program on the outcome of pregnancy
(Hb 11g/dl) an 8.7% of their infants (n=230) have
in primigravidae in The Gambia,” Trans. R.
a hemoglobin at birth below 14g/dl. There is an
Soc. Trop. Med. Hyg., vol. 90, no. 5,
association between pregnancy anemia and
pp. 487–492.
malaria. A case control study in pregnant women
and an infant cohort study to 18 months of age, Abstract: In 1992, the Gambian national
are employed to study the cause and effects of impregnated bed net program (NIBP) introduced
anemia and malaria on women and their infants insecticide treatment of bed nets into half of the
health. primary health care villages in The Gambia. One
component of the evaluation of this program was
the determination of whether it had any impact on
Cot, M., A. Roisin, D. Barro, A. Yada, J. P. the outcome of pregnancy in primigravidae. From
Verhave, P. Carnevale, and G. Breart. 1992. February 1992, 651 primigravidae were recruited
“Effect of chloroquine chemoprophylaxis into the study. Less than 50% of them used an
during pregnancy on birth weight: results of a insecticide-treated bednet. During the rainy season
randomized trial,” Am. J. Trop. Med. Hyg., the prevalence of Plasmodium falciparum among
77
the rainy season, when malaria transmission is low birthweight, and maternal anemia. PIB were
maximal. Ninety mothers and their newborns were well tolerated and had no apparent adverse effect
included. We assessed the clinical status of the on the pregnancy or infant development. Although
mother and child at the time of the delivery, and the overall effect of bed nets on patent parasitemia
took blood smears to check for parasitemia and was marginal, they were associated with a
blood samples to check for antimalaria antibodies significant reduction in maternal malaria-associated
by indirect immunofluorescence (IIF). The placenta anemia.
was not examined. Clinical signs of malaria (fever,
splenomegaly, anemia, and jaundice) were absent in
all mothers and children and 88 of the 90 children Fischer, P. R. 1997. “Congenital malaria: an
had normal birthweights. Plasmodium falciparum African survey,” Clin. Pediatr. (Phila.), vol. 36,
was the only parasite detected, with 49 of the no. 7, pp. 411–413.
90 mothers and 12 of the 90 newborns having
positive blood smears. Serological tests detected the Abstract: Even in malaria-endemic areas,
presence of antimalaria antibodies in 73 of the congenital malaria has been considered to be rare.
90 mothers (81.1%) and 68 of the 90 newborns Some recent reports suggest, however, that up to
(75.5%). Thus, we found no cases of congenital one fourth of newborns in some areas may be
malaria with clinical signs in this study, despite the parasitemic. In an effort to determine current
high frequency of parasites and antimalaria prevalence rates of congenital malaria, malaria
antibodies. The reasons for this absence of cases of smears were done on peripheral blood from
congenital malaria with symptoms are discussed. 100 peripartum mothers and on cord blood from
their offspring at each of seven sites spanning sub-
Dolan, G., F. O. ter Kuile, V. Jacoutot, N. J. White, Saharan Africa. The prevalence rate of maternal
C. Luxemburger, L. Malankirii, T. parasitemia was 15% overall and varied from
Chongsuphajaisiddhi, and F. Nosten. 1993. 4% to 30% at the different sites. Congenital
“Bed nets for the prevention of malaria and malarial infection was found in 7% of newborns,
anemia in pregnancy,” Trans. R. Soc. Trop. the prevalence rate varying from 0% to 23% at the
Med. Hyg., vol. 87, no. 6, pp. 620–626. different sites. There was no apparent relationship
between the season of sampling and either the
Abstract: A prospective comparison of the prevalence rates of parasitemia or the penetrance of
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
antimalarial efficacy of bed nets was conducted malaria from mother to offspring. In summary,
with 341 pregnant women living in a mesoendemic congenital malarial infection is not rare in sub-
malarious area of the Thai-Burmese border. Saharan Africa, but the prevalence rate of neonatal
Women in three adjacent study sites were allocated parasitemia varies from site to site.
at random to receive either a single size
permethrin-impregnated bed net (PIB), a non-
impregnated bed net (NIB), or to a control group Galbraith, R. M., H. Fox, B. Hsi, G. M. Galbraith,
who used either their own family size non- R. S. Bray, and W. P. Faulk. 1980. “The human
impregnated bed net (FNIB) or no net. In one study materno-foetal relationship in malaria. II.
site, but not the other two, PIB significantly Histological, ultrastructural and
reduced parasite densities and, together with FNIB, immunopathological studies of the placenta,”
reduced the incidence of malaria in pregnancy from Trans. R. Soc. Trop. Med. Hyg., vol. 74, no. 1,
56% to 33% (relative risk=1.67, confidence pp. 61–72.
interval=1.07–2.61, P=0.03, allowing for parity). Abstract: Histological and ultrastructural studies of
Anemia proved a more sensitive marker of bed net four placentae heavily infected with Plasmodium
antimalarial efficacy than parasite rates. The falciparum revealed large intervillous
incidence of anemia (haematocrit <30%) at all accumulations of erythrocytes containing parasites
study sites was significantly lower at delivery in the together with monocytes which had ingested
PIB (27%) and FNIB groups (21%) than in the pigment. These appearances were associated with
NIB group (41%) or those using no net (56%). focal syncytial necrosis, loss of syncytial microvilli
This suggests that a significant proportion of the and proliferation of cytotrophoblastic cells. In
malaria in pregnancy in this mesoendemic area was addition, marked irregular thickening of
sub-patent. Both patent Plasmodium falciparum trophoblastic basement membranes and protrusion
parasitemia and anemia were associated with a of tongue-like projections of syncytiotrophoblast
reduction in birthweight. Infant mortality was high into the basement membrane were observed. In six
(16%) and strongly associated with prematurity, other placentae which contained scanty amounts of
78
pigment but no parasites, representing past or CI: 0.73 to 0.99, three studies). Maternal
inactive infection, no large collections of parasitemia was lower with the intervention
monocytes or abnormalities of trophoblast were (RR=0.24, 95% CI: 0.14 to 0.42, random effects
apparent but basement membrane thickening was model, six studies), and mean birthweight higher
evident. Immunohistological studies revealed no (WMD=122g, 95% CI: 81 to 164g, eight studies),
significant differences between placentae positive and low birthweight was less common
for parasites and those containing pigment only, (RR=0.49, 95% CI: 0.36 to 0.65, six studies).
although the amount of certain immunoproteins REVIEWER’S CONCLUSIONS: Drugs given
and clotting factors was clearly increased above routinely for malaria during pregnancy reduce
normal. These findings establish that P. falciparum severe antenatal anemia in the mother, and are
infection in the placenta may result in substantial associated with higher birthweight and probably
damage although lesions within the villus are rare. reduced perinatal mortality. This effect appears to
Furthermore, previous infection, although be limited to low parity women.
adequately controlled, may leave a heritage of
pigment deposition, basement membrane
thickening and immunopathological lesions. These Garner, P. and A. M. Gulmezoglu. 2000.
results may thus account for both the high “Prevention versus treatment for malaria in
frequency of intrauterine growth retardation and pregnant women,” Cochrane. Database. Syst.
the rarity of congenital malaria in the presence of Rev., no. 2, p. CD000169.
P. falciparum malaria. Abstract: OBJECTIVES: Malaria contributes to
antenatal anemia and slowing of fetal growth,
especially in first-time mothers. It is thought that
Garner, P. and A. M. Gulmezoglu. 2003. “Drugs
these effects harm the mother and baby, and
for preventing malaria-related illness in
interventions to prevent or mitigate the effects of
pregnant women and death in the newborn,”
malaria are often recommended. The objective of
Cochrane. Database. Syst. Rev., no. 1,
this review was to assess the effects of anti-malarial
p. CD000169.
interventions in pregnant women living in malarial
Abstract: BACKGROUND: Malaria contributes to areas on the mother and the infant. SEARCH
maternal illness and anemia in pregnancy, STRATEGY: We searched the Cochrane Infectious
Large controlled trials, with treatment available to TABs (deltamethrin) to 70,000 pregnant women in
placebo groups, are required to test whether routine 35 districts throughout Kenya around Africa
chemoprophylaxis has advantages over early, Malaria Day. This intervention represented the
effective treatment of clinical malaria. single largest operational distribution of ITN
services in Kenya to date, and this study evaluates
its success, limitations and costs. The tracking
Gomes, M. 2002. Malaria in pregnancy (review process from the central level through to antenatal
letter) 80. clinic (ANC) facilities suggests that of the 70,000
Abstract: Full letter available at: nets procured, 37,206 nets (53%) had been
http://www.who.int/bulletin/pdf/2002/bul-5-E- distributed to pregnant women throughout the
2002/80(5)418.pdf country within 12 weeks. One-fifth of the nets
procured (14,117) had gone out to individuals
other than pregnant women, most of these at the
Greenwood, B. M., A. M. Greenwood, R. W. request of the district teams, with only 2,870 nets
Snow, P. Byass, S. Bennett, and A. B. Hatib- estimated to have gone astray at the ANC facilities.
N’Jie. 1989. “The effects of malaria At 12 weeks, the remaining 18,677 nets were still
chemoprophylaxis given by traditional birth in storage awaiting distribution, with more than
attendants on the course and outcome of two-thirds having reached the district, and nearly
pregnancy,” Trans. R. Soc. Trop. Med. Hyg., half already being held at ANC facilities. The cost
vol. 83, no. 5, pp. 589–594. of getting a net and K-O TAB to an ANC facility
Abstract: A trial of malaria chemoprophylaxis ready for distribution to a pregnant woman was
given by traditional birth attendants was US$3.81. Accounting for the 14,117 nets that had
undertaken in a rural area of The Gambia where gone to other users, the cost for an ITN received
access to antenatal clinics is difficult. Women by a pregnant woman was US$ 5.26. Delivering
received one or more doses of Maloprim or ITNs free to pregnant women through ANCs uses
placebo from a traditional birth attendant during an existing system (with positive spin-offs of low
80
delivery cost and simple logistics), is equitable (as it were avoidable under the prevailing circumstances.
not only targets those who can afford it) and can DESIGN: Review of stillbirths and neonatal deaths.
have the added benefits of strengthening ANC SETTING: Rural northern Tanzania, Mbulu and
service, delivery and use. Hanang districts. SAMPLE: One hundred and
nineteen stillbirth and neonatal deaths identified in
a prospective cohort of antenatal attendees and
Guyatt, H. L. and R. W. Snow. 2001. “Malaria in 21 stillbirths and neonatal deaths identified
pregnancy as an indirect cause of infant retrospectively in a household survey in seven rural
mortality in sub-Saharan Africa,” Trans. R. Soc. communities. METHODS: Verbal autopsy was
Trop. Med. Hyg., vol. 95, no. 6, pp. 569–576. done to reach a diagnosis, in many cases
Abstract: Although randomized controlled trials of supplemented with information from antenatal
interventions to reduce malaria in pregnancy have records and hospital records. The avoidability of
demonstrated an increase in the birthweight of the deaths under the prevailing circumstances was
newborn in primigravidae, the subsequent impact assessed for each case. An account of risk factors
on infant mortality in all-parities has not been detectable at antenatal clinic was done and
assessed. The aim of this paper was to model the compared with the woman’s recall of the risk
possible impact of placental malarial infection on assessment and recall of being referred. OUTCOME
infant mortality through reduced birthweight. An MEASURES: Avoidability of stillbirths and neonatal
extensive literature search was undertaken to deaths. RESULTS: There were 60 stillbirths,
define a series of parameters describing the 49 early neonatal deaths and 27 late neonatal
associations between placental infection, deaths. Infection-related deaths were most common
birthweight and premature mortality in sub- (n=53), followed by asphyxia-related deaths (n=32)
Saharan Africa. It was shown that a baby is twice and immaturity-related deaths (n=20). Malaria was
as likely to be born of low birthweight if the the most common infectious agent observed
mother has an infected placenta at the time of (21 children and 20 mothers). Twenty-one deaths
delivery (all-parities: 23% vs. 11%, primigravidae (15%) were probably avoidable and 13 (10%) were
only: 32% vs. 16%), and that the probability of possibly avoidable. A patient-oriented avoidable
premature mortality of African newborns in the factor was identified in 17 (51%) and a provider-
first year of life is three times higher in babies of oriented avoidable factor was identified in 22 cases
81
congenital malaria, 13% transfusional malaria, and Lamikanra, O. T. 1993. “A study of malaria
13% had acquired malaria. Plasmodium parasitaemia in pregnant women, placentae,
falciparum was found in all positive smears. cord blood and newborn babies in Lagos,
Bacterial cultures of blood, urine, and Nigeria,” West Afr. J. Med., vol. 12, no. 4, pp.
cerebrospinal fluid were sterile. The predominant 213–217.
clinical features were those of fever (88%),
Abstract: The peripheral blood of 101 pregnant
respiratory distress (57%), pallor and anemia
women at delivery, their 105 newborn babies and
(38% each), hepatomegaly (31%), and jaundice
the corresponding placental and cord blood smears
and diarrhea (25% each). Twenty-five percent of
were examined cross sectionally for malaria
the neonates were resistant to chloroquine
parasites, during a three-month period (May–July,
sulphate; 19% of the chloroquine resistant babies
1986). The average maternal age was 26.3 years.
were also resistant to quinine sulphate 13% of
Positive parasitemia was found in 2.97% of
whom responded to halofantrine hydrochloride.
maternal peripheral thick blood films; in 2.94% of
One died a day after completing a full course of
placental smears, and in 0.95% of cord blood
quinine, with a post-mortem blood smear showing
films. Congenital malaria did not occur in the
no change in the density of parasitemia.
babies.
83
Iron supplementation was not accompanied by Ndyomugyenyi, R. and P. Magnussen. 2000.
increased susceptibility to malaria infection; there “Chloroquine prophylaxis, iron-folic acid
was no difference in the prevalence and severity of supplementation or case management of
peripheral blood or placental malaria infection malaria attacks in primigravidae in western
between the two groups of women. The Uganda: effects on maternal parasitaemia and
birthweight of children born to women who haemoglobin levels and on birthweight,” Trans.
received iron prophylaxis was increased by an R. Soc. Trop. Med. Hyg., vol. 94, no. 4,
average of 56g. It is concluded that oral iron pp. 413–418.
prophylaxis can be successfully delivered through
Abstract: The effects of weekly chloroquine
TBAs integrated into a primary health care
prophylaxis, daily iron-weekly folic acid
program. This simple intervention can produce
supplementation or passive case management on
significant beneficial effects on the health of the
maternal hemoglobin and parasitemia and on
mother without inducing increased susceptibility to
birthweight were examined in primigravidae in a
malaria and has the potential for reducing perinatal
randomized, double-blind placebo-controlled
mortality by increasing birthweight.
intervention trial in 1996–98 in Hoima District,
western Uganda. Iron-folic acid supplementation
Mutabingwa, T. K., L. N. Malle, A. de Geus, and significantly increased mean birthweight as
J. Oosting. 1993. “Malaria chemosuppression compared to case management (P=0.03). Low
in pregnancy. II. Its effect on maternal birthweight (<2.5kg) occurred in 2% of babies of
haemoglobin levels, placental malaria and birth women receiving chloroquine prophylaxis for
weight,” Trop. Geogr. Med., vol. 45, no. 2, pp. > or = eight weeks and in 9% in the case
49–55. management group (RR=0.36, 95% CI: 0.13–1.00,
P=0.009). Parasitemia at enrollment significantly
Abstract: The malaria prophylactic effects of correlated with low birthweight in the case
chloroquine (CQ), proguanil (PROG), and management group as compared to the
chloroquine-proguanil combination (CQ+PROG) intervention groups (P=0.02). Women in the case
during pregnancy on maternal hemoglobin levels management group who were parasitemia and had
(Hb), placental malaria, and birthweight were hemoglobin levels <100g/L at delivery had babies
assessed in Muheza, Tanzania. Within two months with lower mean birthweight as compared to
of prophylaxis, severe anemia in primigravidae babies in the other groups (P=0.04). Low
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
(PG) was reduced from 21% (22 cases) to 13% hemoglobin level at enrollment, irrespective of
(13 cases). There was no positive effect in parasitemia status, was a predictor of low
multigravidae (MG). Sustained increases in the birthweight in the case management group only
mean Hb occurred in PG of the PROG and (P=0.04). Chloroquine prophylaxis and iron-folic
CQ+PROG groups. The mean Hb of PG of the acid supplementation significantly increased
CQ group decreased after an initial increase, maternal hemoglobin levels during pregnancy as
possibly due to the selection of more and highly compared to case management (P=0.01 and
chloroquine-resistant strain(s). The mean P=0.007, respectively) and the increase correlated
birthweight of PG was highest in the CQ+PROG to the duration of the intervention.
(2.89kg) and least in the CQ group (2.71kg). The
CQ group had the highest low birthweight rate
(LBW). The prevalence of placental malaria was Nyirjesy, P., T. Kavasya, P. Axelrod, and P. R.
highest in the CQ (28%) and lowest in the PROG Fischer. 1993. “Malaria during pregnancy:
group (12%). For all the prophylactic effects, neonatal morbidity and mortality and the
PROG and CQ+PROG did not differ significantly. efficacy of chloroquine chemoprophylaxis,”
Thence, the deployment of CQ+PROG for Clin. Infect. Dis., vol. 16, no. 1, pp. 127–132.
prophylaxis would be unnecessary. Proguanil is a
Abstract: In malaria-endemic regions, the impact of
suitable alternative to chloroquine prophylaxis.
malaria upon pregnancy and the value of
Due to possible emergence of proguanil resistance,
chemoprophylaxis for malaria for pregnant women
deployment of this drug should incorporate
remain controversial. We prospectively studied
constant monitoring for resistance and the
302 pregnant women who presented in labor to
eventual prophylaxis efficacy. The search for other
Centre Medical Evangelique, Nyankunde, Zaire.
effective malaria control measures should
We evaluated the incidence of malarial infection in
continue.
mothers, placentas, and neonates and examined the
effect of infection on birthweight and perinatal
mortality. We analyzed the outcome of pregnancy
84
in relation to prophylaxis with chloroquine, antimalarial drug efficacy and adverse drug
controlling for parity and prenatal clinic reactions. Twenty-seven percent (93 of 343) of
attendance. Peripartum smears of maternal blood pregnant women in the CM group had placental
(21%), placentas (33%), cord blood (9%), and malaria compared with 12% (38 of 330; P<0.001)
neonatal blood (7%) were positive for Plasmodium of women who received two doses of SP and
falciparum. Maternal malaria increased the risk of compared with 9% (28 of 316; P<0.001) of
perinatal death (relative risk [RR]=12.4) and low women who received monthly SP. Fourteen percent
birthweight (RR=3.7). Neonatal malaria increased (49 of 341) of women in the CM group delivered
the risk of perinatal death (RR=7.2). Chloroquine low birthweight (LBW) infants compared with
prophylaxis protected against maternal (RR=0.4) 8% (27 of 325; P=0.118) of women who received
and fetal malaria (RR=0.2), low birthweight two doses of SP and compared with 8% (26 of
(RR=0.39), and perinatal death (RR=0.38). 331; P=0.078) of women who received monthly SP.
Peripartum malaria increases the risk of perinatal Seven percent (7 of 99) of the HIV-negative women
death and low birthweight. Chemoprophylaxis on the two-dose SP regimen had placental malaria
with chloroquine during pregnancy may have a compared with 25% (10 of 39; P=0.007) of HIV-
protective effect, even in certain areas where positive women on the same regimen; the rate of
chloroquine-resistant P. falciparum is endemic. placental malaria in HIV-positive women was
reduced to 7% (2 of 28; P=–0.051) for women on
the monthly SP regimen. Less than 2% of women
Olowu, J. A., A. Sowunmi, and A. E. Abohweyere. reported adverse drug reactions, with no
2000. “Congenital malaria in a hyperendemic statistically significant differences between HIV-
area: a revisit,” Afr. J. Med. Med. Sci., vol. 29, positive and HIV-negative women. Intermittent
no. 3-4, pp. 211–213. treatment with SP is safe and efficacious for the
Abstract: Screening of 104 mother-baby pairs for prevention of placental malaria in pregnant
P. falciparum malaria revealed that 29% of primigravidae and secundigravidae in sub-Saharan
mothers from low socio-economic group and 11% Africa. While a two-dose SP regimen may be
of their babies had malaria parasitemia. The effective in areas with low HIV seroprevalence,
corresponding figures for middle and high socio- administration of SP monthly during the second
economic groups were 15% and 7%, respectively. and third trimesters of pregnancy should be
86
all gravidities. METHODS: Between January 1996 nonpregnant women. The average weight of
and July 1997, 912 women delivering in Kilifi 155 neonates from infected mothers was 350g less
District Hospital, Kenya, were recruited. than that of 175 neonates from noninfected
Hemoglobin and peripheral malaria slides were mothers. This difference in birthweight was
taken prior to delivery, placental biopsies and statistically significant for both P. falciparum
smears were taken at the time of delivery and (P<0.0001; df=278) and P. vivax (P<0.0001;
birthweight and maternal height and weight were df=223) infection. Congenital malaria was not
measured soon after birth. Information was recorded. We conclude that pregnant women from
obtained on socio-economic and educational status. this geographical area require systematic
The association between placental malaria, severe intervention owing to their high susceptibility to
anemia, and low birthweight was investigated for malaria during pregnancy and the puerperium.
women of different gravidities. FINDINGS: By
placental histology, the prevalence of active or past
malaria in all gravidities was high, ranging from Sirima, S. B., R. Sawadogo, A. C. Moran, A.
64% in PG to 30% in gravidities five and above. Konate, A. Diarra, M. Yameogo, M. E. Parise,
In gravidities one to four, active malaria infection and R. D. Newman. 2003. “Failure of a
was associated with severe maternal anemia, chloroquine chemoprophylaxis program to
adjusted OR=2.21 (95% CI: 1.36, 3.61). There adequately prevent malaria during pregnancy in
was a significant interaction between chronic or Koupela District, Burkina Faso,” Clin. Infect.
past malaria and severe anemia in their effects on Dis., vol. 36, no. 11, pp. 1374–1382.
birthweight, whereby the risk of low birthweight Abstract: In West Africa, administration of
was very high in women with both chronic or past chloroquine chemoprophylaxis during pregnancy is
placental malaria and severe anemia: OR=4.53 common, but little is known about its impact on
(1.19, 17.2) in PG; 13.5 (4.57, 40) in gravidities Plasmodium falciparum infection during
2–4. INTERPRETATION: In this area of moderate pregnancy. Therefore, cross-sectional studies in
malaria transmission, women of all parities have antenatal care clinics (ANCs) and delivery units
substantially increased risk of low birthweight and (DUs) were conducted in Koupela District, Burkina
severe anemia as a result of malaria infection in Faso. Chloroquine chemoprophylaxis was reported
pregnancy. The risk of low birthweight is likely to by 69% of 597 pregnant women at ANCs and by
experience a variety of adverse consequences from The principle findings of the MMRP include:
malaria infection including maternal anemia, 1) populations at risk of the adverse consequences
placental accumulation of parasites, low of malaria in pregnancy include women with low
birthweight (LBW) from prematurity and parity, women infected with human
intrauterine growth retardation (IUGR), fetal immunodeficiency virus, pregnancy during the high
parasite exposure and congenital infection, and malaria transmission season, and the use of a
infant mortality (IM) linked to preterm-LBW and malaria drug that is suboptimally efficacious; 2) the
IUGR-LBW. We reviewed studies between 1985 estimated maximum benefits of an antimalarial
and 2000 and summarized the malaria population intervention that clears placental and umbilical
attributable risk (PAR) that accounts for both the cord parasitemia are a 5%–12% reduction of low
prevalence of the risk factors in the population and birthweight (LBW), an approximately
the magnitude of the associated risk for anemia, 35% reduction in the risk of LBW for risks that
LBW, and IM. Consequences from anemia and are actually preventable once a woman has become
human immunodeficiency virus infection in these pregnant (e.g., risks such as infectious disease or
studies were also considered. Population poor nutrition during gestation), and a 3%–5%
attributable risks were substantial: malaria was reduction in the rate of infant mortality; 3) the
associated with anemia (PAR range = 3%–15%), intervention must be capable of rendering the
LBW (8%–14%), preterm-LBW (8%–36%), woman malaria parasite free, including clearance
IUGR-LBW (13%–70%), and IM (3%–8%). of parasites from the placental vascular space and
Human immunodeficiency virus was associated umbilical cord blood; 4) other diseases adversely
with anemia (PAR range = 12%–14%), LBW affect pregnancy outcome and, while the control of
(11%–38%), and direct transmission in 20%–40% malaria in pregnancy may not warrant independent
of newborns, with direct mortality consequences. programming, if coupled with prevention programs
Maternal anemia was associated with LBW (PAR to provide a range of antenatal services, the
range = 7%–18%), and fetal anemia was incremental costs of malaria control may prove to
associated with increased IM (PAR not available). be highly cost-effective; and 5) the choice of a
88
regimen must balance intervention efficacy with season; HIV-seropositivity; and maternal age < or =
safety, availability, affordability, and simplicity of 25 years (risk for peripheral and placental blood
delivery, and several antimalarials may meet these parasitemia only). Maternal anemia (hematocrit
criteria. The Malawi Ministry of Health has <30%) at enrollment or at delivery was not
modified its malaria prevention in pregnancy associated with persistent or breakthrough
recommendations and now faces the challenge of parasitemia or parasitemia at deliver in these
effective programming to improve child survival. multivariate models. While factors leading to
increased malaria parasite exposure (high
transmission seasons) and lowered or altered host
Steketee, R. W., J. J.Wirima, L. Slutsker, J. M. immune response (low pregnancy number, young
Roberts, C. O. Khoromana, D. L. Heymann, age, and HIV infection) are important risk factors
and J. G. Breman. 1996. “Malaria parasite for malaria in pregnant women, the use of an
infection during pregnancy and at delivery in ineffective intervention (CQ in a setting with CQ-
mother, placenta, and newborn: efficacy of resistant parasites) was the most important
chloroquine and mefloquine in rural Malawi,” determinant of P. falciparum parasitemia in these
Am. J. Trop. Med. Hyg., vol. 55, no. 1 Suppl, pregnant women. Strategies to reduce the impact of
pp. 24–32. malaria in pregnant women must use efficacious
Abstract: Despite international recommendations interventions and may need to consider targeting
to use malaria treatment and prevention in the intervention to the most susceptible women
pregnant women in malaria-endemic areas, few during the seasons of high malaria exposure.
studies have evaluated the efficacy of available
antimalarial regimens. This issue is of particular
Taha, T. T., R. H. Gray, and A. A. Mohamedani.
concern in the face of spreading chloroquine (CQ)-
1993. “Malaria and low birth weight in central
resistance of Plasmodium falciparum in malarious
Sudan,” Am. J. Epidemiol., vol. 138, no. 5,
areas of sub-Saharan Africa. In a prospective trial
pp. 318–325.
in rural Malawian pregnant women, we examined
three regimens using CQ (including the existing Abstract: A nested case-control hospital study and
national policy regimen) and one regimen using a midwife-based community cohort study were
mefloquine (MQ). The efficacy of the regimens was conducted in Central Sudan during 1989 and 1990
2%–47%) in gravidae one to four from ITN Parasitol., vol. 93 Suppl 1, pp. S25–S33.
villages. No beneficial impact was observed in
gravidae five or higher. In areas of intense perennial Abstract: Maternal malaria and anemia, pregnancy
malaria transmission, permethrin-treated bed nets and infant outcomes are reviewed among a cohort
reduce the adverse effect of malaria during the first of mothers and their babies living in Chikwawa
four pregnancies. district, southern Malawi. Overall, 4,104 women
were screened at first antenatal visit and 1,523 at
delivery. Factors independently associated with
van Eijk, A. M., J. G. Ayisi, F. O. ter Kuile, A. O. moderately severe anemia (MSA; <8g
Misore, J. A. Otieno, D. H. Rosen, P. A. Kager, hemoglobin/dl) in primigravidae were malaria
R. W. Steketee, and B. L. Nahlen. 2003. “HIV (relative risk=1.9; 95% confidence interval:
increases the risk of malaria in women of all 1.6–2.3) and iron deficiency (relative risk=4.2;
gravidities in Kisumu, Kenya,” AIDS, vol. 17, 95% confidence interval: 3.5–5.0). Only iron
no. 4, pp. 595–603. deficiency was associated with MSA in
multigravidae. After controlling for antimalarial
Abstract: OBJECTIVE: To study the importance of
use, parasitemia was observed in 56.3% of the
HIV infection for malaria in pregnancy in Kisumu,
HIV-infected primigravidae and 36.5% of the non-
Kenya. SUBJECTS AND METHODS: Healthy
infected (P=0.04). The corresponding figures for
women with an uncomplicated pregnancy of
multigravidae were 23.8% and 11.0%, respectively
32 weeks or more attending the prenatal clinic in
(P=0.002). Over 33% of the infants born alive to
the Provincial Hospital between June 1996 and
primigravidae were of low birthweight (LBW;
March 1999 were tested for HIV and malaria after
<2,500g), and 23.3% of all newborns had fetal
consent had been obtained. For participating
anemia (<12.5g hemoglobin/dl cord blood). LBW
women who delivered in the same hospital, a blood
was significantly associated in primigravidae with
smear of the mother and the placenta were
preterm delivery, placental malaria and frequency
obtained. RESULTS: In the third trimester,
of treatment with sulfadoxine-pyrimethamine (SP),
5,093 women consented to testing: the prevalence
90
and in multigravidae with preterm delivery, and multi-gravidae who had received two or three
adolescence, short stature and MSA. LBW was doses of SP treatment than those seen in babies
significantly reduced with a second SP treatment in born to women who had had just one dose (P<0.03
primigravidae, and with iron-folate for each). The odds ratio for LBW in primigravidae
supplementation in multigravidae. Mean compared with multigravidae decreased from 3.2 to
hemoglobin concentrations were significantly lower 1.0 as the number of SP doses increased from one
in the infant who had been LBW babies than in the to three. The benefit of three doses (compared with
others, and significantly associated with parity, none) was equivalent to the population-attributable
peripheral parasitemia at delivery and placental risk of LBW in primigravidae being reduced from
malaria. At one year post-delivery, life status was 34.6% to 0%. Subjects who were seropositive for
known for 364 (80.7%) of the 451 infants enrolled HIV were twice as likely to give birth to LBW
in the follow-up study. Independent risk factors for babies as the other subjects. The use of SP was not
post-neonatal mortality were maternal HIV associated with maternal side-effects or perinatal
infection, LBW, and iron deficiency at delivery. complications. The present results indicate that
This study identifies priorities for improving the multiple doses of SP taken during pregnancy will
health of pregnant women and their babies in this lead to a highly significant reduction in the
rural area of Malawi. incidence of LBW in infants born to primigravidae,
even if the women have HIV infections. This
reduction is observable even when parasite
Verhoeff, F. H., B. J. Brabin, L. Chimsuku, P. prevalence at delivery is high because of re-
Kazembe, W. B. Russell, and R. L. Broadhead. infections in late pregnancy; reduction in parasite
1998. “An evaluation of the effects of prevalence earlier in pregnancy, as the result of SP
intermittent sulfadoxine-pyrimethamine treatment, leads to improved fetal growth.
treatment in pregnancy on parasite clearance
and risk of low birthweight in rural Malawi,”
Ann. Trop. Med. Parasitol., vol. 92, no. 2, Wolfe, E. B., M. E. Parise, A. C. Haddix, B. L.
pp. 141–150. Nahlen, J. G. Ayisi, A. Misore, and R. W.
Steketee. 2001. “Cost-effectiveness of
Abstract: The prevalence of infection with malarial
sulfadoxine-pyrimethamine for the prevention
parasites and the incidence of anemia and delivery
91
prevent 172 and 229 cases of LBW, respectively, Abstract: Congenital Plasmodium falciparum
compared with the case management approach. At malaria in newborns is uncommon in sub-Saharan
HIV seroprevalence rates greater than 10%, the Africa. A significant number of infants, however,
monthly SP regimen is the least expensive strategy. become infected or exposed to malarial antigens
At HIV seroprevalence rates less than 10%, the either in utero or at delivery and have the potential
two-dose SP regimen would be the less expensive to produce antimalarial antibodies and memory
option. When only antenatal clinic costs are cells before their first natural infection. In
considered, the two-dose and monthly SP strategies Yaounde, Cameroon, parasite-specific
cost U.S. $11 and $14, respectively, well within the immunoglobulin M (IgM) was detected in 14% of
range considered cost effective. Presumptive cord blood samples. The IgM antibodies reacted
treatment regimens to prevent LBW associated with a wide range of asexual-stage antigens, with
with malaria and the subsequent increased risk of each newborn having its own unique pattern of
mortality during the first year of life are effective IgM reactivity. PCR-based detection and
and cost effective strategies in areas with both genotyping of cord blood parasites found that the
elevated HIV prevalence and malaria transmission prevalence, total number of parasite genotypes, and
rates. complexity of infection were higher in newborns
who had produced antimalarial IgM than those
who had not. Maternal placental malaria and
Xi, G., R. G. Leke, L. W. Thuita, A. Zhou, R. J. anemia were associated with the production of
Leke, R. Mbu, and D. W. Taylor. 2003. P. falciparum-specific IgM by the fetus. The effect
“Congenital exposure to Plasmodium of early immune priming on acquisition of
falciparum antigens: prevalence and antigenic immunity by infants is unknown and merits further
specificity of in utero-produced antimalarial investigation, since a significant proportion of
immunoglobulin M antibodies,” Infect. Cameroonian newborns developed a humoral
Immun., vol. 71, no. 3, pp. 1242–1246. response to malaria before birth.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
92
3. Programs Targeted for Newborn
Health and Experiences in
Newborn Care
Programs for and Experiences in Newborn Care
Aubel, J., et al. 2002. NGO promising practices. 47 control villages in the Gadchiroli district in
Building collaborative NGO networks to share India, collected baseline data for two years
lessons learned about community health. (1993–1995), and then introduced neonatal care in
BASICS. the intervention villages (1995–1998). Village
health workers trained in neonatal care made home
Abstract: This report focuses on the “Promising
visits and managed birth asphyxia, premature birth
Practices” workshops for nongovernmental
or low birthweight, hypothermia, and breastfeeding
organizations (NGOs) in Burkina Faso and Senegal
problems. They diagnosed and treated neonatal
conducted by the Basic Support for
sepsis. Assistance by trained traditional birth
Institutionalizing Child Survival in 1997. The
attendants, health education, and fortnightly
workshops aim to assist NGOs in examining the
supervisory visits were also provided. Other
effectiveness of their own programs, and identify
workers recorded all births and deaths in the
and document which of their activities held the
intervention and the control area (1993–1998) to
most promise for improving child survival and
estimate mortality rates. FINDINGS: Population
community health. The participating NGOs then
characteristics in the intervention and control
shared these promising practices with each other.
areas, and the baseline mortality rates (1993–1995)
The workshops can be considered as a catalyst for
were similar. Baseline (1993–1995) neonatal
participants in at least four ways. First, NGOs that
mortality rate in the intervention and the control
participated implemented practices they learned
areas was 62 and 58 per 1,000 live births,
from other NGOs. Second, many participants used
respectively. In the third year of intervention
the community mapping analysis and other
93% of neonates received home-based care.
analytical tools they learned to critically examine
Neonatal, infant, and perinatal mortality rates in
and improve their programs and practices. Third,
the intervention area (net percentage reduction)
the workshops have initiated an active process of
compared with the control area, were
networking and collaboration among participating
25.5 (62.2%), 38.8 (45.7%), and 47.8 (71.0%),
NGOs. Lastly, the workshops have increased
respectively (p<0.001). Case fatality in neonatal
collaboration between NGOs and the Ministries of
sepsis declined from 16.6% (163 cases) before
Health in both countries. Results suggest that such
treatment, to 2.8% (71 cases) after treatment
workshops may be an effective method for
by village health workers (p<0.01).
95
refused referral even when advised therefore was associated with neonatal, but not with
community based health workers and traditional intrapartum, cases.
birth attendants managed cases of neonatal
pneumonia with co-trimoxazole. Case fatality was
15% (10/65) in all cases and 6% (3/52) in cases Bartlett, A. V., M. E. Paz de Bocaletti, and M. A.
without high risk or referral indications. Case Bocaletti. 1991. “Neonatal and early postneonatal
fatality in 56 babies aged 30–59 days treated for morbidity and mortality in a rural Guatemalan
pneumonia was zero. During the two years of the community: the importance of infectious diseases
trial, pneumonia specific mortality rate in the and their management,” Pediatr. Infect. Dis. J.,
intervention area was 40% less in the neonates and vol. 10, no. 10, pp. 752–757.
about 80% less in the second month and rest of
infancy compared with the control area. Abstract: We conducted a one-year longitudinal
Pneumonia in the second month of infancy and prospective study of infants born in a traditional
uncomplicated cases of neonatal pneumonia can be rural indigenous community of Guatemala. Three
safely and effectively managed in the community hundred twenty-nine infants surviving birth and
using co-trimoxazole. the first day of life were followed during the first
three months of life. Surveillance included routine
Bartlett, A. V. and M. E. Paz de Bocaletti. 1991. household and well baby clinic visits and clinic
“Intrapartum and neonatal mortality in a visits for minor illnesses. Detection of potentially
traditional indigenous community in rural lethal illnesses depended on orientation of families
Guatemala,” Acta Paediatr. Scand., vol. 80, and midwives to important symptoms and to the
no. 3, pp. 288–296. need for immediate medical evaluation if such
symptoms were identified. We identified
Abstract: We identified high rates of intrapartum 38 episodes of lethal and potentially lethal illness.
and neonatal mortality among children born in a Thirty-five (92%) of these episodes were infectious
traditional indigenous community in rural diseases, principally sepsis during the neonatal
Guatemala. To examine the potential association of period and acute lower respiratory infection in
maternal characteristics and obstetric and newborn months two and three. Of all study infants, low
care practices with this mortality, we conducted a birthweight (less than 2,500g) infants comprised
retrospective case-control study. Case were infants 14% and premature (less than 37 weeks’ gestation)
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
born in 1986 and 1987 who died during birth or in infants comprised 1%. Premature infants had a
the first month of life, as identified by civil records; relative risk of lethal and potentially lethal illnesses
for each case, the next child born who survived the of 11.1 (95% confidence interval (CI): 3.6–34.4)
first month of life was selected as control. In compared with normal term infants, and no
interviews with mothers of cases and controls premature infant survived the first three months of
standardized data were collected on demographic life despite medical intervention. Low birthweight
and socioeconomic characteristics of the mother, infants had a relative risk of 3.2 (95% confidence
her general obstetric history, history of the interval (CI): 1.5–6.6), but with medical
pregnancy, labor, and delivery, condition and care intervention all but two survived. Despite their
of the infant at birth, and morbidity and lower risk, because of their much greater number
treatments of the infant after birth. Sixty-one cases normal term infants experienced 60% of lethal and
and their controls were included in the study. Based potentially lethal illnesses. Among all study infants
on clinical condition at birth, we subcategorized medical intervention was associated with survival
cases into infants stillborn or dying in the first of 86% of lethal and potentially lethal infectious
24 hours of life (intrapartum cases) and those illnesses and with a rate of neonatal mortality
dying in the first month after day one (neonatal among study children significantly lower than rates
cases). Factors significantly associated with both documented in previous years in the same
subcategories of cases were maternal illiteracy, community.
primagravity, failure to use “modern” prenatal
care, and inter-birth interval less than 14 months.
Intramuscular injection of oxytocin by the midwife Bhakoo, O. N., R. Khajuria, A. Desai, and A.
during labor, and performance of greater than or Narang. 1989. “Lessons from improved
equal to three vaginal examinations by the midwife neonatal survival at Chandigarh,” Indian
were each significantly associated only with the Pediatr., vol. 26, no. 3, pp. 234–240.
intrapartum subcategory of cases. Mother’s Abstract: We observed a significant fall in neonatal
estimate of infant size as “smaller than normal” mortality in babies weighing less than 2kg during
96
1986 as compared to 1973 (7.94% vs. 12.88%; improved in a third of the cases (83/235) which
p<0.005), and in preterm babies the mortality fell could have led to further reduction of perinatal
from 26.88% to 11.5% (p<0.001) during 1986. mortality rate.
This was achieved despite a two- to three-fold
increase in the high risk babies and without any
increase in the number of neonatal special care Bolam, A., D. S. Manandhar, P. Shrestha, M. Ellis,
beds or nurses. Effective utilization of the facilities and A. M. Costello. 1998. “The effects of
was made possible through: (a) reduction in postnatal health education for mothers on
admissions to neonatal special care unit of babies infant care and family planning practices in
with birthweight more than 1,500g; (b) early Nepal: a randomized controlled trial,” BMJ,
discharge of babies to home from NSCU; (c) vol. 316, no. 7134, pp. 805–811.
involvement of the mothers in the care of their high Abstract: OBJECTIVES: To evaluate impact of
risk babies: and (d) care of babies with sucking postnatal health education for mothers on infant
difficulties and asymptomatic birth asphyxia care and postnatal family planning practices in
outside NSCU. All babies discharged home at less Nepal. DESIGN: Randomized controlled trial with
than 2kg weight, and living in Chandigarh were community follow up at three and six months
followed for three months and 98.2% were doing postpartum by interview. Initial household survey
well. This observation highlights the judicious use of study areas to identify all pregnant women to
of neonatal special care facilities and mothers for facilitate follow up. SETTING: Main maternity
the care of high risk neonates. hospital in Kathmandu, Nepal. Follow up in urban
Kathmandu and a periurban area southwest of the
city. SUBJECTS: 540 mothers randomly allocated
Biswas, A., S. Chew, R. Joseph, S. Arulkumaran,
to one of four groups: health education
C. Anandakumar, and S. S. Ratnam. 1995.
immediately after birth and three months later
“Towards improved perinatal care—perinatal
(group A), at birth only (group B), at three months
audit,” Ann. Acad. Med. Singapore, vol. 24,
only (group C), or none (group D).
no. 2, pp. 211–217.
INTERVENTIONS: Structured baseline household
Abstract: Perinatal audit is a measure of quality of questionnaire; 20-minute, one-to-one health
care given in pregnancy and it gives an idea as to education at birth and three months later. MAIN
how the resources need to be allocated for better OUTCOME MEASURES: Duration of exclusive
outcome. The perinatal mortality data in the breastfeeding, appropriate immunization of infant,
National University Hospital over a seven-year knowledge of oral rehydration solution and need to
period (1986–1992) were compiled and compared continue breastfeeding in diarrhea, knowledge of
97
Abstract: A workable model for the special care of room; 2) “aggressive” stabilization of a nursery
newborns has been developed at a community admission; 3) establishment of perinatal audit
hospital in a predominantly tribal block. Adequate sessions; 4) developing management schedules for
warmth, prompt resuscitation, proper feeding and common problems like respiratory distress, and
oxygen administration, when necessary, formed the asphyxia; 5) teaching and training of staff nurses at
key interventions. This facility was developed with neonatal unit as well as at labor ward; and
existing staff and infrastructure and with minimal 6) utilization of postnatal care ward as an
material inputs. Neonatal survivals were 61.5% in intermediate care unit. The features were arrived at
the 1,000g–1,500g category and 92.5% in the because of compulsions of circumstances such as
1,520g–2,000g category during a five-year period. broken incubators, limited medical supply budgets
We believe that this model is both replicable and to buy infant formula and shortage of trained
affordable. It has the potential for developing nurses. The results of these changes are seen in the
horizontal links with perinatal care and child reduction of neonatal deaths for very low
survival programs. birthweight babies (from 84.6% dying using
conventional methods from January 1–March 9,
1987 to 50% mortality from March 10–June 20,
Bugalho, A. and S. Bergstrom. 1993. “Value of 1987 under the new set-up). Follow-up of
perinatal audit in obstetric care in the discharged babies showed that the post-neonatal
developing world: a ten-year experience of the mortality in this high-risk group was for the
Maputo model,” Gynecol. Obstet. Invest., general population in the city of Bombay. An
vol. 36, no. 4, pp. 239–243. important reason may be that few mothers had
Abstract: A decade of perinatal audit in the given up breastfeeding when surveyed at one year.
Maputo Central Hospital is reviewed with the The qualitative follow-up also revealed that the
objective of addressing the potential value of the quality of survival is comparable with that under
audit process in monitoring the different conventional care. With the declining trend in
constituents of morbidity and mortality in the mortality, the difference is reduced from
perinatal period. The perinatal mortality showed a approximately 25 years to about 10 years in
significant but transient change during the various weight categories when compared with
observation period 1982–1991, while intrapartum England and Wales. More importantly, this kind of
fetal mortality was significantly reduced from neonatal care can be made available outside of
teaching institutions at an affordable cost The total
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
98
Daga, S. R., A. S. Daga, R. V. Dighole, R. P. Patil, care was supervised by the auxiliary nurse-midwife,
and H. L. Dhinde. 1992. “Rural neonatal care: the anganwadi worker and the traditional birth
Dahanu experience,” Indian Pediatr., vol. 29, attendant, with good relations between them and
no. 2, pp. 189–193. the family members. All six babies survived
without requiring hospital admission. This example
Abstract: The Rural Neonatal Care Project, started
of successful management, by a rural primary
by the Government of Maharashtra in the Ganjad
health center, of high-risk newborns at home
Primary Health Centre, Dahanu block in
demonstrates how important it is to have a suitably
Maharashtra, had the TBA as the sheet anchor for
trained health worker and community health
delivery of neonatal care. Maintenance of “warm
workers to coordinate with the family and give
chain” and resuscitation of an asphyxiated baby
them the support and supervision they need.
were recognized as the most important
interventions besides detection of a very low
birthweight/preterm baby and safe transportation Duke, T., L. Willie, and J. M. Mgone. 2000. “The
of such a baby. Foot length measurement from foot effect of introduction of minimal standards of
print was used as a surrogate to birthweight as an neonatal care on in-hospital mortality,” P. N. G.
indicator for referral. Neonatal and perinatal Med. J., vol. 43, no. 1-2, pp. 127–136.
mortality rates dropped appreciably over three
years and the antenatal registration went up by Abstract: A retrospective study was done to assess
30%. The cost of this program is affordable and the effect on in-hospital neonatal mortality of a
the program itself was acceptable to the series of interventions in neonatal care in the
community and the TBAs because of its simplicity. highlands of Papua New Guinea. Between
1995 and 1997, prior to the interventions, the
mortality among neonates admitted to the Goroka
Daga, S. R., R. V. Dighole, and R. P. Patil. 1996. Hospital Special Care Nursery was 18% and two-
“Managing very-low-birth-weight babies at thirds of very low birthweight (1kg–1.5kg)
home in a rural area [letter],” World Health neonates died. The interventions began in
Forum, vol. 17, no. 3, pp. 289–290. December 1997 and were aimed at reducing
mortality among all neonates and particularly
Abstract: The Ganjad primary health center
among those with very low birthweight. Compared
provides services to a population of 22,000 people
to the 30-month period prior to the interventions,
140km northwest of Bombay. A rural neonatal care
the in-hospital neonatal mortality in the
program was put into operation in 1988 in the
30-month period after the interventions began
area covered by the health center. Under the
was 44% lower (relative risk (RR)=0.56,
program, the care of newborns was administered at
99
similar evaluation of the effect of minimal The manual is divided into four sections:
standards should be done without the use of Section 1: contains an explanation of the
incubators and overhead heaters, as these are costly underlying philosophy of the project and
and may be dangerous when used by less describes the conditions within the project area.
experienced operators. The 33 neonatal deaths that It deals with the training of SC/B’s staff and the
we estimate were avoided each year because of the preparation for the project, including the
interventions represent less than 10% of all baseline study that was carried out prior to
neonatal deaths in the province. Although this initiating project activities.
study provides justification for increasing the
Section 2: is the main section of the manual and
technology for supportive neonatal care and
is a step-by-step guide to the project. It contains
training in medium-sized hospitals in rural areas in
four subsections detailing all the stages that
developing countries, estimates of cost-effectiveness
need to be followed and includes a
must be compared with other interventions that
comprehensive guide for facilitators.
will effectively lower neonatal mortality, both in
and out of hospitals. Section 3: describes the implementation
components of the Warmi Project and includes
information on lessons learned by SC/B during
Dyal, C. A. and M. Khale. 1989. “A community
the three-year implementation period.
based surveillance system for perinatal and
neonatal care,” Indian Pediatr., vol. 26, no. 11, Section 4: presents the results of the Warmi
pp. 1115–1121. Project, along with conclusions and
recommendations for PVOs who wish to use the
Abstract: The impact of maternal health services on
project methodology.
perinatal and neonatal mortality depends on both
the quantitative and qualitative coverage of Published by:
pregnant women with obstetric services. In rural MotherCare (www.jsi.com)
areas this becomes all the more difficult because of Save the Children (www.savechildren.org)
the requirement of a large decentralized 2000 M Street, Suite 500
infrastructure extending from village based health Washington, DC, 20036 USA
workers and subcenters to the Primary Health Tel: 202-293-4170.
Centre and tertiary levels of referral. An effective
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
100
facilities was improved through modifying health in emergency care of obstetric patients, provision
professionals’ attitude towards TBAs and clients, of supplies for management of preeclampsia-
and implementation of management protocols. In eclampsia, creation of a directory of state blood
Indonesia, the University of Padjadjaran addressed banks, treatment of incomplete abortion, vigilance
issues of referral and emergency obstetric care in of cesarean deliveries, neonatal cardiopulmonary
the West-Java subdistrict of Tanjunsari. Birthing resuscitation and screening for congenital
homes with radios were established in ten of the metabolic anomalies, promotion of breastfeeding,
27 villages in the district, where trained modified hospital procedures, and mortality study
nurse/midwives provided maternity care on a committees. The work ends with an outline of
regular basis. In Nigeria professional midwives research conducted recently or planned for the near
were trained in interpersonal communication and future.
lifesaving obstetric skills, while referral hospitals
were refurbished and equipped. While reduction in
maternal mortality after such a short MotherCare. 2000. Africa initiatives: addressing
implementation period is difficult to demonstrate, obstetric and neonatal complications in Africa
all projects showed improvements in referral and in from community and facility perspectives.
reduction in perinatal mortality. Abstract: This document presents three descriptive
and qualitative country assessment reports focusing
on the Safe Motherhood Initiatives in Ghana,
Mexico. Secretaria de Salud. Direccion General de
Malawi, and Uganda. Health representatives of
Salud Reproductiva. 2000. Healthy and safe
each country were able to complete facility-based
motherhood. Care of the mother during
assessments that describe the level of maternal and
pregnancy, childbirth and the postpartum
newborn services in their respective country. They
period and care of the newborn/Maternidad
also described specific interventions that can
saludable y sin riesgos. Atencion de la mujer
increase both the quality and access of care. Each
durante el embarazo, parto y puerperio y del
country assessment report contains a country
recien nacido.
profile, assessment methodology and assessment
Abstract: Mexico’s Reproductive Health and findings, and recommendations. The key findings
Family Planning Program 1995–2000 is being in the Ghana report are: increasing coverage of
implemented in coordination with the maternal newborn and neonatal statistics; increased
decentralization of health services, the basic packet knowledge and positive attitudes as a result of
of health services, and the new model of health information, education, and communication on
care for the uncovered population, which safe motherhood activities; successful cooperation
Gynecology of the University of Pretoria developed urban population, Pretoria, South Africa.
a Perinatal Problem Identification Program (PPIP) SUBJECTS: All perinatal deaths of infants weighing
based upon the ICA Solution system of audit. The more than 1,000g from urban areas served by
PPIP can document any improvement in the Kalafong Hospital between August 1991 and July
perinatal and neonatal mortality rates in the 1992. METHODS: All perinatal deaths were
Atteridgeville area and allow for feedback to be classified according to the primary obstetric cause
given to the community. This paper reports upon of death and neonatal cause of death, and whether
the changes in perinatal and neonatal mortality any avoidable factors were present which could
rates and upon the format of a meeting with the have contributed to the death. RESULTS: The
community. The perinatal mortality rate (PNMR) perinatal mortality rate was 26/1,000 deliveries.
and neonatal mortality rate (NMR) during the Avoidable factors occurred in 58% of perinatal
period August 1, 1991, through June 30, 1992, deaths. Our problem areas which were immediately
were compared with the PNMR and NMR during remedial were identified as labor management-
May 1–October 30, 1994. The PNMR fell from related problems, administrative problems in
26.6/1,000 to 16.6/1,000, a 38% decrease in obtaining syphilis results, and estimation of fetal
mortality, while there was an even greater decrease weight. Other problem areas which need to be
in the NMR. Some decrease was observed in the solved are patient education, early attendance at
number of stillbirths. The pattern of causes of clinics, improved documentation and continuing
death also changed over the three years, with education of medical personnel. CONCLUSION:
spontaneous preterm labor and unexplained The use of this classification of avoidable factors
stillbirths having become the major causes of has enabled the detection of problem areas that can
mortality, assuming the former importance of be improved immediately at very little cost.
hypertensive disease and antepartum hemorrhage,
causing only 17.5% of deaths compared to
36.2% previously. The occurrence of avoidable Paul, V. K. and A. V. Ramani. 2000. “Newborn
factors decreased between 1991/2 and 1994, but care at peripheral health care facilities,” Indian
J. Pediatr., vol. 67, no. 5, pp. 378–382.
102
Abstract: Primary health centers, sub-district home, attended by relatives or traditional birth
hospitals (first referral units) and district hospitals attendants and without easy access to skilled
constitute the backbone of the health services in professional care. Under these circumstances cause
the country. These facilities are expected to cater to of death has to be based on lay descriptions of
the care of the newborn infants who are delivered terminal events. Analysis of cause of death shows
there, as well as those brought from the that 74% of the early neonatal deaths are
community with sickness. This paper, based on a amenable to intervention. Admittance to hospital
survey in Orissa, and studies in a district hospital of the “at risk” neonates is not practicable.
in Himachal Pradesh and a sub-district hospital in Intervention through primary health care can be
Haryana, is an attempt to piece together the effective if based on scientific principles and offered
present status of neonatal care at these facilities. In through female community health workers.
Orissa, the district and sub-district hospitals cater Objectives of domiciliary care given by these
to a median of 100 and 30 deliveries per month, workers should be to educate and guide the mother
respectively. Most of the deliveries at these facilities to protect the delicate newborn from the effects of
are conducted by the nurses and not the physicians. adverse environmental conditions, to ensure
Neonates are generally kept in the facility only for adequate nutrition, and to prevent infections.
a day. Hardly any deliveries take place at primary Interventions supporting beneficial traditional
health centers. Cesarean deliveries are mostly cultural practices as well as simple techniques for
confined to the district hospitals. The commonest care of the newborn are discussed.
diagnosis of neonates admitted in the district and
sub-district facilities is sepsis (septicemia
pneumonia, skin infections, diarrhea and Shah, U., A. K. Pratinidhi, and P. V. Bhatlawande.
meningitis). Primary health centers seldom admit a 1984. “Perinatal mortality in rural India: a
sick neonate. It is reassuring to note that the strategy for reduction through primary care. I
outcome of sick neonates admitted at a functional Stillbirths,” J. Epidemiol. Community Health,
district or sub-district hospital manned by a vol. 38, no. 2, pp. 134–137.
pediatrician is highly rewarding with low mortality Abstract: In a prospective community based study
rates. of the distribution and determinants of stillbirths in
a rural area of Maharashtra, India, that was
carried out for two years, 3,129 singleton and
Pratinidhi, A., U. Shah, A. Shrotri, and N.
22 twin births were recorded in a population of
Bodhani. 1986, “Risk-approach strategy in
47,000. Of the 3,173 babies, 85 singletons and five
neonatal care,” Bull. World Health Organ.,
of the twins were stillborn giving a stillbirth rate of
vol. 64, no. 2, pp. 291–297.
104
perinatal mortality. DESIGN: Retrospective audit maternity services in the health ward, development
of 1,060 perinatal deaths between 1 January 1991 of key standing orders and management guidelines,
and 31 December 1992. SETTING: Livingstone and creation of a monitoring system for perinatal
Hospital Maternity Service. SUBJECTS: One mortality.
thousand and sixty perinatal deaths, where the
gestational age exceeded 28 weeks or, when
gestational age was unknown, the birthweight was Wilkinson, D. 1993. “Statistics of perinatal
equal to or exceeded 1,000g. MAIN OUTCOME mortality due to error or omission: a suggestion
MEASURES: All perinatal deaths were identified of how to improve care,” Trop. Doct., vol. 23,
and classified by primary obstetric cause for no. 3, pp. 119–121.
perinatal loss. In the second year of the study Abstract: This examination shows how routinely-
avoidable factors were sought and, if found, graded collected perinatal mortality statistics can help to
and categorized. RESULTS: The major primary improve the quality of care among deliveries in
obstetric causes of perinatal loss identified and hospitals. Data were obtained on 6,488 consecutive
amenable to intervention were intrapartum trauma, hospital and clinic births over a 19-month period
intrapartum asphyxia and infection. In the second in Zululand, South Africa, excluding birthweights
year of study potentially avoidable factors were below 1,000g. Graphs were constructed to show
sought and identified in almost 50% of perinatal perinatal mortality, the potential perinatal
deaths. Appropriate intervention lowered the mortality which eliminates avoidable death, and
perinatal mortality rate by 23% (P<0.05; odds the differences between the rates. Basic problems
ratio 0.76; 95% confidence interval: 0.67–0.86). with delivery of health care, which can be avoided,
CONCLUSION: The ICA Solution method of were failure to take prenatal blood samples to test
perinatal audit identified problems in overall for syphilis, failure to refer hypertensive patients
obstetric care, facilitating a significant fall in for hospital care and subsequent intrauterine death,
perinatal mortality. and failure to manage basic labor ward
emergencies correctly. Avoidable death accounted
for about 33% of all perinatal mortality. Perinatal
Wilkinson, D. 1995. “Avoidable perinatal deaths in
mortality over the study period (1991/1992) was
a rural hospital: strategies to improve quality of
35/1,000 total births. Prevention of avoidable
care,” Trop. Doct., vol. 25, no. 1, pp. 16–20.
deaths would have reduced perinatal mortality to
Abstract: Data was analyzed on all infants born at 31/1,000. The graph depicted the dramatic decline
Hlabisa Hospital and at seven village clinics in in avoidable deaths in the first six months and the
northern Zululand, South Africa, and those born stabilization at an average of 11.8% over the
105
conditions that encourage effective community used to develop an analytical framework for
participation. Addressed to health planners, the understanding why such programs so often fail to
book concentrates on questions of management reach their goals.
and human behavior that need to be considered
Available at:
when planning health programs based on the
http://www.who.int/dsa/cat98/mat8.htm
concept or methods of community participation.
Throughout the book, numerous case studies are
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
106
Capacity Building, Including Training Materials/Tools
American College of Nurse-Midwives. 1998. Life- use by policy makers, program planners and
saving skills manual for midwives, 3rd edition. trainers. It includes detailed guidance for first
planning a LSS program at the national level (e.g.,
Abstract: This manual, comprised of 10 modules in
reviewing current policies and standards;
five volumes, is designed for use by practicing
developing a detailed plan; and identifying trainers
midwives in continuing education programs to
and a training site); then assessing midwives’
improve their ability to provide lifesaving
training needs and preparing for training; and
interventions for women and infants. The manual
finally undertaking the training itself. Curricula are
employs a competency-based clinical training
provided for training of trainers in LSS and a two-
methodology. Midwives are encouraged to manage
week LSS training for midwives themselves. Also
their own learning, share responsibility with
included are guidelines on supervision of the
trainers, and draw on their own experience. Active
trained midwives (follow up and support visits)
problem solving is encouraged, and each module
and continuing education. Each part of the manual,
contains several case studies—real and
which is broken into short sections called steps,
hypothetical—through which midwives can apply
contains an overview of that section’s contents and
the skills they have learned. The 10 modules that
clear, concise discussions of topics. Charts,
comprise the manual are: 1) Introduction to
diagrams and checklists are included throughout,
Maternal Mortality; 2) Quality Antenatal Care;
and at the end of the manual there is an extensive
3) Monitoring Labor Progress; 4) Episiotomies and
set of lesson plans for teaching LSS along with
Repair of Lacerations; 5) Prevention and Treatment
relevant forms.
of Haemorrhage; 6) Resuscitation; 7) Prevention
and Management of Sepsis; 8) Hydration and 305 pp. English.
Rehydration; 9) Vacuum Extraction; and 10) Other
ORDERING INFORMATION: Document can be
Emergencies (labor and delivery problems,
ordered using the online form at
postabortion care (PAC), and symphysiotomy). Each
http://www.acnm.org/prod/ or by phone at
module follows the same format, including: goals,
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objectives and a brief introduction to the material to
107
Available at: to increase training and deployment of skilled birth
http://www.jsi.com/intl/seats/publications/ attendants; practicing midwives, to review their
pub01_02.html skills before enrolling in an advanced midwifery
training course; or by midwifery educators
developing lesson plans for midwifery trainings. At
American College of Nurse-Midwives and the beginning of the manual, a short section
MotherCare/John Snow, Inc. 1998. Healthy describes the four step “midwifery problem-solving
mothers and healthy newborn care: a guide for process” to determine what care clients need and
caregivers. how best to provide it; this process is applied
Abstract: This pocket-sized guide for midwives and throughout the manual. Subsequent chapters cover
other care providers is designed to provide a quick infection prevention; antenatal care; care during
reference to maternal and infant care during the three stages of labor; and postpartum care for
pregnancy, delivery and in the postpartum period. new mothers and infants up to six weeks after
This is not a “how-to guide”; it has been written delivery. Each chapter contains a set of objectives
jointly with Healthy Mothers and Healthy followed by step-by-step guidance to determining
Newborn Care: A Reference for Caregivers (see the need for and providing various aspects of
description below), which is a comprehensive maternal and infant care; within the chapters are
manual for providing maternal and infant care. exercises, quizzes, sample scenarios, practice
Divided into four sections, this pocket guide problems and illustrations that highlight and apply
contains four chapters: 1) management of the information and skills covered and assess
complications or abnormalities in the antenatal progress in learning. An opening chapter offers
period, during labor, postpartum and in the ideas for how midwives can better work with their
newborn; 2) standard tests and procedures (e.g., communities, including helping community
treatment for fever, hemoglobin test); 3) use of members identify health problems, understand their
medications (e.g., antibiotics, oxytocics); and causes, and agree on ways to solve these problems
4) a comprehensive set of checklists that outline to improve maternal and infant health.
problem-solving steps for each stage of maternal 249 pp. English.
and infant care. These are provided so that
midwives can rate their own skills, or so ORDERING INFORMATION: The set can be
supervisors can evaluate midwives’ performance. ordered for U.S. $32.00, using the online form at
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
The guide’s chapters are organized into concise http://www.acnm.org/prod/ or by phone at 1-202-
tables, boxes or short sections of text so that 728-9860.
information can be found quickly and easily. Guide
is sold as a set with the manual, Healthy Mothers
Carlough, M. 2002. Postpartum and newborn
and Healthy Newborn Care: A Reference for
care, a self-study manual.
Caregivers.
Abstract: This self-study manual provides accurate
104 pp. English.
and accessible information on postpartum and
ORDERING INFORMATION: The set can be newborn care to trainers of traditional birth
ordered for U.S. $32.00, using the online form at attendants (TBAs) and other community-level
http://www.acnm.org/prod/ or by phone at 1-202- Maternal and Child Health (MCH) Workers. The
728-9860. information can be integrated into existing training
curricula and materials or it can be adapted into
additional units for an ongoing program of
American College of Nurse-Midwives and instruction for TBAs. The manual is organized into
MotherCare/John Snow, Inc. 1998. Healthy eight units: 1) Community assessment,
mothers and healthy newborn care: a reference 2) Postpartum assessment and care, 3) Nutrition
for caregivers. and breastfeeding, 4) Postpartum blues and
Abstract: This manual compiles clinical postpartum depression, 5) Postpartum family
information on how to provide basic midwifery planning, 6) Postabortion care, 7) Newborn
care, as well as ideas and strategies for ensuring assessment and care, and 8) Management of
positive interactions between midwives and common newborn problems. Each unit begins with
community members. Designed for practicing a purpose, learning objectives, a pretest, self-study
midwives and nurse-midwives, this manual may content, a posttest, and a vocabulary list. Some
also be useful to other health staff providing units include case stories and exercises for practice
maternal and infant care; health planners seeking in applying the new information. The appendices
108
of the manual include a checklist to document the Lawn, J., B. J. McCarthy, and S. Ross. 2001. The
users progress; answers to the pre- and post-tests; healthy newborn: a reference manual for
and information on training TBAs and community- program managers.
level MCH workers, including preparing for
Abstract: Of the estimated eight million babies who
training, planning, conducting and evaluating the
die just before birth or in the first 28 days of life,
training, as well as a sample training course
98% die in developing countries. Yet almost all the
timetable.
books about newborn health are aimed at the 2%
Source: Chapel Hill, North Carolina, University of of deaths in high-technology care in industrialized
North Carolina at Chapel Hill, School of Medicine, countries. There is a dearth of information to
Program for International Training in Health enable program managers to design, implement
(INTRAH), PRIME Project, 1999. 144 p. and evaluate effective interventions to address the
important problem of improving newborn health.
This manual has grown out of a partnership
Klein, S. 2002. A book for midwives: a manual for between the WHO Collaborating Center in
traditional birth attendants and community Perinatal Care at the Centers for Disease Control
midwives. and CARE. While implementing programs to
Abstract: This manual is a comprehensive, clinical address fetal and neonatal mortality, we realized
guide for providing care to pregnant women and the need for such a reference manual and CD-
their infants, particularly in areas that are far from ROM resource.
maternity centers, or where care is not widely ORDERING INFORMATION:
available to poor people. It offers guidance for CARE USA, Program Division
providing high quality prenatal, delivery, and 115 Ellis Street, NE
postnatal care; treating or referring complications Atlanta, GA 30303-2440
of labor and birth; providing family planning; Tel: 404-681-252
treating STDs and raising awareness of how to Web: www.care.org
prevent them; and promoting positive health
practices among women and their families. The
manual is designed to be accessible to a broad Ross, S. R. 1998. Promoting quality maternal and
range of care-givers, including professional newborn care: a reference manual for program
midwives and nurse-midwives, auxiliary midwives, managers.
111
Midwifery training modules: Puerperal sepsis World Health Organization. 1994. Home-based
module WHO/FRH/MSM/96.4 maternal records: guidelines for development,
Midwifery training modules: Eclampsia module adaptation and evaluation.
WHO/FRH/MSM/96.5
Abstract: The home-based maternal record—like
Midwifery training modules: Notes for students
the child growth chart—represents a simple,
WHO/FRH/MSM/96.6
appropriate technology that can have a significant
impact on maternal and child health. A prototype
World Health Organization. 1994. Care of mother home-based maternal record was developed by the
and baby at the health centre: a practical World Health Organization (WHO) in 1982 to
guide. facilitate the early detection of risk conditions,
promote timely referral of at-risk cases, improve
Abstract: Written for health planners and program the monitoring of health status for up to 10 years
managers, this guide defines the functions, tasks, after pregnancy, and increase community
and skills necessary to provide comprehensive, involvement in health care. A multicenter review of
integrated care to mothers and babies before, the maternal health card conducted by WHO in
during, and after pregnancy within health centers 14 countries in 1984–88 indicated this tool
and in communities. It breaks health centers into increased the referral rate, the use of prenatal care,
two categories: type I, in which reproductive health attendance at postpartum check-ups, and
care is usually limited to prenatal care and family childhood immunization rates while also
planning services; and type II, which provide more promoting self-reliance and the participation of
comprehensive ambulatory and curative services mothers in their own health care. Since that time,
and are staffed by a team of professional and the WHO prototype record has been adapted to
auxiliary health workers. Within these two local health needs and conditions by almost
typologies, the guide outlines facility- and 30 centers. The protocol presented in this volume
community-based reproductive health care is intended for use by decision makers in health
interventions that can and should be provided. It ministries, obstetricians, program managers, and
also discusses how health centers can establish community health leaders who want to introduce
functional referral systems, undertake training and the maternal record to their own health system.
supervision of staff, collect data, and promote and Detailed information is provided on the functions
support community-based care by TBAs and/or and benefits of the records, how they should be
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
community health workers. A final section covers adapted and introduced to the primary care system,
evaluation and monitoring of quality maternal and and steps that should be taken in advance of large-
infant care, and annexes list essential drugs and scale use. Also included is information on the
equipment for providing such care. training of community health workers, nurse-
54 pp. English. midwives, and physicians.
112
infant mortality in resource-poor settings. planning, quality antenatal care, clean and safe
Recommended interventions were selected on the delivery, and access to essential obstetric care for
basis of considerable scientific knowledge about high-risk pregnancies and complications.
the causes of complications during pregnancy and
Available at:
childbirth and the best ways to prevent them.
http://www.who.int/dsa/cat98/mat8.htm#Mother-
Pragmatic as well as scientifically valid, the
Baby Package: Implementing Safe Motherhood in
package can be implemented within the existing
Countries
health care system and without the need for
sophisticated equipment, expensive drugs, or
additional resources and facilities. WRS Group, I. 2002. Childbirth graphics.
The document, which is addressed to national Childbirth graphics catalog.
decision-makers and health planners, provides both
an explanation of general strategies crucial to the Abstract: Available from:
success of the Package and a detailed guide to the WRS Group, Inc.
actions required to implement each of the 18 core Childbirth Graphics
interventions. Concerning strategic issues, the book P.O. Box 21207
advocates an integrated approach to service Waco, TX 76702-1207
delivery aimed at reducing the number of high-risk Tel: 1-800-299-3366
and unwanted pregnancies, reducing the number of Web: www.wrsgroup.com
complications, and reducing case fatality rates
when complications occur. Essential service-related
components of the package are identified as family
113
Traditional Birth Attendants
Alisjahbana, A., J. Widjaya, and A. Sukadi. 1984. 3.5-year period 1988–1991, 2,568 attacks of
“A method of reporting and identifying high childhood pneumonia were managed and the case
risk infants for traditional birth attendants,” J. fatality rate was 0.9%, compared with a rate of
Trop. Pediatr., vol. 30, no. 1, pp. 17–22. 13.5% in the control area. The case fatality rates
for the three types of worker were similar. The
Abstract: Traditional birth attendants (TBAs) are
TBAs were superior to the other workers in terms
still respected in rural and urban societies and are
of their availability, outreach, access to neonates,
influential leaders in the community. They can be
and cost. Satisfaction with the VHWs, and PMWs
guided towards positive roles in MCH services
was expressed by 85%, 69%, and 18% of users,
through a carefully planned training program with
respectively. In the intervention area the mortality
emphasis on the use of simple aids for reporting
rate attributable to pneumonia among neonates
and identification of high risk infants. This study
declined by 44% (P<0.01) while the total neonatal
designed special weight scales in which calibration
mortality fell by 20%, presumably because of the
was put in different colors for each 500g interval.
involvement of TBAs in the control of acute
A pictorial form showing the condition of the child
respiratory infections (ARI). If adequately
directly after birth, based on three indicators—
supported by the health system, TBAs can
color, activity and presentation—was also designed.
successfully manage childhood pneumonia in
The risk-score was calculated for each indicator.
villages at the lowest possible cost and with a high
Twenty out of 40 TBAs were selected by simple
degree of community acceptance. TBAs and VHWs
random sampling in an urban community. They
are the most suitable community-based health
were required to report the condition of the child
workers for ARI control programs in developing
using the colored weight scales by filling out forms.
countries.
A midwife was present at each delivery; she would
examine the infant using the Apgar score and
report the infant’s birthweight in grams. Both Carvalho, I., A. S. Chacham, and P. Viana. 1998.
worked independently. No significant differences “Traditional birth attendants and their practices
were found between the mean birthweight as in the State of Pernambuco rural area, Brazil,
reported by the TBA and the midwife. Comparing 1996,” Int. J. Gynaecol. Obstet., vol. 63
the Apgar score and the risk score, it showed that a Suppl 1, pp. S53–S60.
low Apgar score correlates with a high risk score.
This study showed that the TBAs were able to Abstract: OBJECTIVE: To obtain socioeconomic
report and identify high risk infants based on information about TBAs in the State of
birthweight and condition after delivery. Tables and Pernambuco and information concerning their
charts present data on age, parity, birthweight practices. METHOD: Statistical analysis of the
distribution, infant mortality and causes, and answers to structured questionnaires applied to
delivery complications. 127 TBAs. RESULTS: The results of a survey with
127 TBAs conducted in the rural area of the State
of Pernambuco (Brazil) is presented in this paper.
Bang, A. T., R. A. Bang, and P. G. Sontakke. 1994. TBAs in rural Pernambuco are a group of basically TRADITIONAL BIRTH ATTENDANTS
“Management of childhood pneumonia by old and very poor and uneducated women. Most
traditional birth attendants. The SEARCH of them learned to attend births by themselves or
Team,” Bull. World Health Organ., vol. 72, by helping another TBA. Thirty percent learned
no. 6, pp. 897–905. midwifery in hospital delivery rooms, helping
doctors and nurses. How the TBAs learned to help
Abstract: In a field trial in Gadchiroli, India, we
births seemed to be the most influential factor on
trained 30 paramedical workers (PMWs),
the kind of practices they use. TBAs who learned
25 village health workers (VHWs) and 86
from other TBAs from the community seem to
traditional birth attendants (TBAs) from 58 villages
have the least interventionist approach, followed
to diagnose childhood pneumonia and treat it with
by the TBAs who learned by themselves. They are
sulfamethoxazole + trimethoprim. Continued
more likely to perform more home births and
training, the development of a breath counter, and
avoid practices such as shaving the pubic hair,
educative supervision progressively reduced errors
vaginal exams, artificial rupture of the membranes,
in case management made by the TBAs. Over the
episiotomy and early cord clamping.
115
CONCLUSION: The way women learned hospital of complications of pregnancy and
midwifery is the most important determinant of delivery and encouraging improvements in many
their practice. other indices of improved management. This short
paper describes the health services available in a
developing country, The Gambia, in West Africa,
Daga, S. R., A. S. Daga, R. V. Dighole, and H. L. and reports an interview with a trained TBA in a
Dhinde. 1996. “Training of traditional birth rural area of the country.
attendants in newborn care,” Indian Pediatr.,
vol. 33, no. 2, pp. 158–159.
Fleming, J. R. 1994. “What in the world is being
Abstract: Appropriate training of traditional birth
done about TBAs? An overview of international
attendants (TBAs) can both increase the proportion
and national attitudes to traditional birth
of births attended by trained persons and enhance
attendants,” Midwifery, vol. 10, no. 3,
linkages between rural communities and modern
pp. 142–147.
health services. Described is a TBA training
program in newborn care developed by the Rural Abstract: Many of the half million women per year
Neonatal Care Project in Maharashtra State, India. who die in childbirth are attended by traditional
To improve attendance, a sub-center was birth attendants (TBAs). Whether they fare better
established for TBAs from the northern part of the when such an attendant is trained remains
primary health care area. In addition, an effort was uncertain; even the World Health Organization
made to train women who assist the TBAs (usually seems to have tempered its enthusiasm for TBA
a close relative). Two training sessions per month training recently. With some nations outlawing the
were held for six months, then the frequency was practice of TBAs and others actively promoting it,
reduced to once a month. TBAs received 5 rupees there seems to be no consensus on what to do
for attending a training session and an additional about this major and continuing workforce in
5 rupees for each registered birth. The training, maternity care. By themselves TBAs cannot reduce
delivered by lady health visitors and auxiliary nurse maternal mortality, whether they are trained or
midwives, used photographs and dolls to not. They need skilled, equipped and available
communicate information about keeping the support. As the professional group who must co-
newborn warm, resuscitating a depressed baby, operate with TBAs and provide that support,
identifying very small infants, and safely midwives must, collectively and individually, assess,
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
transporting at-risk infants to the primary health state and act on their attitude towards TBAs.
care center. Also addressed were immunization,
management of diarrhea, and referral of acute
respiratory infection cases. Program evaluation Goldman, N. and D. A. Glei. 2003. “Evaluation of
highlighted the importance of brief, task-oriented midwifery care: results from a survey in rural
sessions that use demonstrations, case histories, Guatemala,” Soc. Sci. Med., vol. 56, no. 4,
oral questioning, and reviews of material presented pp. 685–700.
in earlier sessions. Since TBAs have extensive Abstract: In an effort to reduce infant and maternal
experience in deliveries in village conditions, they morbidity and mortality in developing countries,
should be regarded by trainers as equal partners. the World Health Organization has promoted the
training of traditional birth attendants (midwives)
and their incorporation into the formal health care
Daly, C. and A. J. Pollard. 1990. “Traditional birth
system. In this paper, we examine several aspects of
attendants in the Gambia,” Midwives. Chron.,
the integration of traditional and biomedical
vol. 103, no. 1227, pp. 104–105.
maternity care that are likely to reflect the quality
Abstract: In developing countries traditional birth of care received by Guatemalan women.
attendants help at 60%–70% of births, despite Specifically, we examine the extent to which
rapidly expanding “Western-style” health services. women combine traditional and biomedical
Recognizing the potential of this established pregnancy care, the frequency with which
service, the World Health Organization has been midwives refer women to biomedical providers, the
involved in a program of training and supervision content and quality of care offered by midwives,
of traditional birth attendants (TBAs) in developing and the effects of midwife training programs on
countries since 1973. An evaluation of training referral practices and quality of care. The analysis
programs in 1986 showed considerable success is based on data from the 1995 Guatemalan Survey
with improved antenatal care, decreased neonatal of Family Health. The results offer a mixed
tetanus, increased recognition and transfer to assessment of the efficacy of midwife training
116
programs. For example, although trained midwives Ibrahim, S. A., M. I. Omer, I. K. Amin, A. G.
are much more likely than other midwives to refer Babiker, and H. Rushwan. 1992. “The role of
their clients to biomedical providers, most pregnant the village midwife in detection of high risk
women do not see a biomedical provider, and the pregnancies and newborns,” Int. J. Gynaecol.
quality of midwife care, as defined and measured Obstet., vol. 39, no. 2, pp. 117–122.
in this study, is similar between trained and
Abstract: The preliminary findings of a prospective
untrained midwives.
study of perinatal, neonatal and maternal
mortality carried out in a rural community of
Gordon, G. 1990. Training manual for traditional Sudan are reported. Out of 6,275 deliveries
birth attendants. monitored over a period of three years, 150
stillbirths, 167 neonatal deaths, and 27 maternal
Abstract: This book is a storehouse of facts and deaths were observed. An intervention program to
information which can be adapted to meet the upgrade the skills of the village midwives started
needs of trainers and TBAs. The book is based on in the middle of the second year. There was a 25%
20 years’ experience by the author. reduction in the risk of unfavorable outcome of
Available at: pregnancy (i.e., stillbirth and neonatal death) in
Teaching Aids at Low Cost (TALC) the third year relative to the first two years. Peer
http://www.talcuk.org/a-z_booklist.htm review of the 40 village midwives who took part
in the study revealed their tremendous potentials
in mobilization of mothers as well as participation
Greenwood, A. M., Bradley, A. K., Byass, P., in primary health care. Their role in detection of
Greenwood, B. M., Snow, R. W., Bennett, S., high risk pregnancies and newborns cannot be
and A. B. Hatib-N’Jie. 1990. “Evaluation of a overemphasized.
primary health care program in The Gambia. I.
The impact of trained traditional birth
attendants on the outcome of pregnancy,” J. Kamal, I. 1992. “Traditional birth attendant
Trop. Med. Hyg., vol. 93, no. 1, pp. 58–66. training: sharing experiences,” Int. J. Gynaecol.
Obstet., vol. 38 Suppl, pp. S55–S58.
Abstract: In 1983 a primary health care (PHC)
program was introduced into the Farafenni area of Abstract: The experiences in TBA training in five
The Gambia; an important component of this countries are contrasted. Successful training must
program was the identification and training of a impart improved skills to the TBAs and follow-up
traditional birth attendant (TBA) in each village that both provides continuing support and meets
with a population of 400 or greater. The outcome the self-interest of the TBAs. The preference of
of pregnancy has been documented among women mothers for services of TBAs is explained.
resident in 15 villages which joined the PHC
program and in 26 which were too small to do so,
Kamal, I. T. 2001. “Impact of training on the
for one year before and for three years after the
practices of traditional birth attendants
start of the program. In PHC villages 65% of
(TBAs),” J. Pak. Med. Assoc., vol. 51, no. 7,
women were assisted at delivery by a trained TBA
pp. 239–240.
during the post-implementation period and the
proportion of women who delivered in a hospital Abstract: Training of TBAs has received a lot of
TRADITIONAL BIRTH ATTENDANTS
or health centre increased. Both maternal and attention and international support in the last
neonatal death rates fell in PHC villages during the century. Yet no country in the world has been able
post-intervention period, declining to about half to make motherhood sater than before by only
the levels recorded during pre-intervention surveys training TBAs. The rare success stories are of those
during the last year of the study. In non-PHC countries which trained, supervised and supported
villages there was also a fall in the maternal death the TBAs with a fairly organized referral system.
rate but little change in the neonatal death rate. Pakistan is not one of these countries. It would be
Trained traditional birth attendants probably wise for a country with limited resources for health
played some part in improving the outcome of care, to move with extreme caution in designing
pregnancy in the Farafenni area but other factors, and implementing TBA training programs. At their
such as improvements in transport, may also have best TBAs should be considered a very temporary
contributed. approach to manage a permanent situation by any
developing country. The authorities need to
concentrate on a “Replacement Strategy” and start
117
investing in an achievable goal of training Kumar, R. 1994. “Effect of training on the
midwives for promoting safer motherhood resuscitation practices of traditional birth
particularly though domiciliary midwifery. attendants,” Trans. R. Soc. Trop. Med. Hyg.,
vol. 88, no. 2, pp. 159–160.
Kamal, I. T. 1998. “The traditional birth Abstract: Training programs in more modern
attendant: a reality and a challenge,” Int. J. methods of birth asphyxia resuscitation were
Gynaecol. Obstet., vol. 63 Suppl 1, started for traditional birth attendants (TBAs) in
pp. S43–S52. 54 villages (population 62,427) of Raipur Rani
Block near Chandigarh, India during 1989–1991. A
Abstract: The traditional birth attendant (TBA) is continuing training program by the primary health
an institution as old as the birthing process in the center staff at four focal villages, for one day each
human species. Generally a female, in the absence month, had been in progress for several years.
of a better alternative, continues to deliver two About 80–100 TBAs attended these sessions.
thirds of the world’s babies. A number of studies Resuscitation methods included gravity drainage of
generated international interest in training TBAs. A secretions, physical stimulation by flicking at the
review of TBA training and utilization programs in soles of the feet, cleaning the mouth by a finger
more than 70 countries over the past three decades wrapped in gauze, mouth-to-mouth breathing,
revealed that there are very limited examples of cardiac massage, and prevention of heat loss by
their successful utilization. If unsupervised the TBA wrapping the baby in multiple layers of cloth. In
tends to slide back into her old ways and if 1988, 31 TBAs also received advanced training in
unsupported she is rendered helpless when a killer the use of the mucus extractor and bag-and-mask
strikes during child birth. The impact of trained ventilation. Two trained field workers visited the
TBAs on maternal mortality ratios is not palpable villages once a fortnight to contact child workers,
because of other factors such as accessibility of TBAs and health workers, and checking the local
essential obstetric services. The challenge for the register of vital events to record births. Family
policy makers is to make the best use of this members and/or the TBA who assisted at the
available human resource but simultaneously plan delivery were interviewed, and a detailed birth
and implement a definite replacement strategy. history was recorded for stillborn and asphyxiated
babies. TBAs assisted with the delivery of
Kumar, R. 1995. “Training traditional birth 1,884 babies (93.7%). Of these, 31 asphyxiated
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
attendants for resuscitation of newborns,” Trop. babies and 30 recently stillborn babies were eligible
Doct., vol. 25, no. 1, pp. 29–30. for the resuscitation survey, but information could
not be collected for two of the stillborn infants.
Abstract: The experience of the pilot project shows Both traditional and modern resuscitation methods
that after receiving training, TBAs did change their were used in 30 cases (51%), modern methods only
practices in favor of modern resuscitation in 13 (22%), traditional methods in two (3%), and
procedures. Perinatal mortality declined by 19%. no resuscitation effort was made in 14 cases (24%).
Asphyxia case-fatality rate was reported to have Among 21 cases delivered by the trained TBAs,
declined from 7.1% to 0.45% after resuscitation mucus traps and bag-and-mask were used in 33.3%
training was given to grassroots maternal and child and 42.6%, respectively. Instillation of onion juice
personnel in a county in China. The use of a mucus and warming of placenta were practiced in a
extractor and bag-and-mask ventilation needs to be significantly higher proportion of cases by
tried in other areas for improving the resuscitation traditionally trained TBAs than by those who had
facilities in home deliveries in the developing received advanced training. Adoption of modern
countries where such facilities are almost non- resuscitation methods by the TBAs demonstrates
existent. In scattered rural populations most of the that they are likely to change their practices.
TBAs conduct only a few deliveries, therefore, very
few asphyxiated babies will be encountered by a
TBA in a given year. Therefore maintenance of the Kumar, R., J. S. Thakur, and A. K. Aggarwal.
skills learnt by TBAs is important. Periodic 2000. “Effect of continuing training on
retraining on a mannequin with inflatable lungs is knowledge and practices of traditional birth
necessary for learning and retention of the attendants about maternal and newborn care,”
resuscitation skills. Indian J. Public Health, vol. 44, no. 4,
pp. 118–123.
Abstract: Seventy-nine traditional birth attendants
(TBAs) of Raipur Rani community development
118
block, Haryana were interviewed to assess the knowledge and practices of trained and untrained
effectiveness of continuing training in changing their TBAs, and in the performance of supervised versus
knowledge and practices regarding maternal and unsupervised trained TBAs. All TBAs demonstrated
newborn care. Seventy-three percent of them poor knowledge and practices in the management
reported participation in continuing training of complications of pregnancy and labor. Reasons
sessions. However, analysis of attendance register suggested for the poor performance included an
showed that only 35.4% had attended more than over ambitious, inappropriate initial training, and
50% sessions in year 1993. Most (83.5%) of the lack of useful supervision. Overall the study
TBAs gave advice to pregnant women for increased concluded that there was a case for continuing
food intake, 47% advised tetanus toxoid, with the training and supervision of TBAs provided
16.5% for more rest, and 31.6% for iron tablets. changes were made to the selection, training and
Many of them were aware of maternal supervision processes.
complications i.e. anemia (64.6%), edema (26.6%),
bleeding per veginum (39.2%), abnormal
presentation (77.2%), and high fever (48.1%). Risks Mathur, N. B., A. K. Gargye, and V. J. Rajput.
to newborn like low birthweight, fever, cough/rapid 1983. “Knowledge attitude and practice of
breathing and hypothermia were known to 20.2%, perinatal care amongst traditional birth
31.6%, 17.7%, and 1.3% of the TBAs, respectively. attendants (DAIS) trained vs. untrained,”
Knowledge regarding causes of low birthweight Indian Pediatr., vol. 20, no. 11, pp. 837–842.
baby like ‘weak’ mother, less diet in pregnancy, Abstract: A comparative study of knowledge,
short birth interval and preterm delivery were attitude, and practice of perinatal care was
reported by 69.6%, 63.3%, 12.6%, and 3.8%, conducted amongst 50 untrained and 50 trained
respectively. About two-fifths of TBAs advised traditional birth attendants (TBAs) from two
referral to hospital in case of prolonged labor and community development blocks of Rewa division
88.6% for very low birthweight babies. Disposable in Madhya Pradesh (Central India). All the TBAs
Dai Kit and weighing machine were available with belonged to Chamar (Cobbler) community, a
32% and 73% TBAs. Significantly higher scheduled caste, were illiterate, and were regarded
proportion of TBAs participating in continuing as social inferiors irrespective of being trained or
training advised tetanus toxoid vaccination, untrained. In spite of having undergone the
appropriate feeding practices of the newborn, training, the trained TBA was never consulted for
hospital referral in case of prolonged labor and were antenatal care, nor for conducting the delivery.
less inclined to advise injection to speed up labor. This job was done by the elderly lady of the house.
Therefore, efforts should be made to increase the The role of the TBA started only after the placenta
attendance of TBAs in continuing training sessions was delivered and the labor room labeled
so as to sustain modern maternal and newborn care “impure.” However the trained TBAs differed from
practices acquired after initial training. the untrained ones in their knowledge and attitude
regarding perinatal care and in their practices of
neonatal and puerperial care. Ninety-six percent of
Lynch, O. and M. Derveeuw. 1994. “The impact of
the trained TBAs realized need for antenatal care
training and supervision on traditional birth
as opposed to only 34% of the untrained TBAs.
attendants,” Trop. Doct., vol. 24, no. 3,
Sixty-six percent of the trained TBAs washed their
pp. 103–107.
hands with soap prior to cutting the cord as
Abstract: A survey of 40 trained and 40 untrained opposed to only 36% of the untrained TBAs. Only TRADITIONAL BIRTH ATTENDANTS
traditional birth attendants (TBAs) was done over 4% of the trained TBAs used sickel and knife for
a three-week period in two counties in Uganda to cord cutting whereas 50% of the untrained TBAs
evaluate the impact of training and supervision on used these crude instruments. None of the
TBAs. Forty womens’ groups and 20 mothers were untrained TBAs approved administration of
also interviewed. The result showed that the most colostrum to newborns whereas 50% of the trained
utilized birth attendants were mothers-in-law, TBAs counseled its administration. Eighty percent
trained and untrained TBAs, and the pregnant of the untrained TBAs were eager to undergo
woman herself. Childbirth was regarded as a training.
normal, private event and the birth attendants were
normally called when labor was well advanced or
in case of complications. Trained TBAs were Piper, C. J. 1997. “Is there a place for traditional
attending three times the number of deliveries as midwives in the provision of community-health
untrained TBAs. There was no difference in the services?” Ann. Trop. Med. Parasitol., vol. 91,
no. 3, pp. 237–245.
119
Abstract: Traditional midwives (TM) have been Abstract: Traditional birth attendants (TBAs) are
involved in delivering babies, and providing a regarded as essential child health care providers in
broad range of other services to women, for Bangladesh. A community-based cross-sectional
hundreds of years. They are usually local women study was completed using questionnaires and
with little formal education. As they are well interviews to compare trained and untrained TBAs’
known in their communities they are often called advice on (1) breastfeeding, (2) immunizations and
to assist women at the time of delivery. Two (3) oral rehydration therapy as an extended part of
opposite views persist about the continuation of their maternity care training. Twenty-eight trained
their role; some health workers would like to see TBAs (TTBAs) and 27 corresponding untrained
them trained better and incorporated into the TBAs (UTBAs) in the Dhaka district were
formal health system. Other health workers feel interviewed to investigate the effect of their advice
that all deliveries should be attended by either a on the three outcome variables of maternal health
nurse/midwife or a doctor, and that TM should care. Additionally, 276 questionnaires were
eventually be phased out. Traditional midwives distributed to the mothers cared for by these TBAs
currently perform >60% of deliveries in some to determine their knowledge of infant-care
developing countries and have had their role practices. In-depth interviews with 25 mothers
expanded in some places. Recruiting provided additional insight. While TTBAs may
nurse/midwives and doctors to work in remote have more knowledge and be more willing to
areas remains difficult and, even if they were disseminate health care information to mothers
recruited, there is no guarantee that their obstetric with new infants than UTBAs, the mother’s health
services would be used. The evaluation of training practices were independent of the advice provided
programs has not produced any clear-cut answers by the two groups of TBAs. Additionally, the
in the debate about the long-term role or existence mother’s health practices equaled or exceeded
of TM. Rather, the studies have shown that the expected norms.
success of the programs depends on the resources
available, the people involved in the training and
how the training is carried out. Some of the lessons Ross, D. A. 1986. “The trained traditional birth
learnt from working with TM apply to any two attendant and neonatal tetanus,” WHO Offset
groups of people working together. If TM are Publ., no. 95, pp. 8–21.
going to be offered training, and this must be a Abstract: One of the most compelling reasons for
local decision made after consultation and an
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
120
administration, the training of TBAs in Haiti cared for or living in areas served by trained TBAs,
showed measurable results. Studies in Senegal, the including maternal and perinatal deaths. The
Punjab, India, Malaysia, and Bangladesh are findings are relevant in light of the current
reviewed. Despite possible confounding factors, the controversy on efficacy of TBA training where
results appear to indicate that TBA training is an home birth is common and maternal and neonatal
effective way to reduce infant mortality, especially mortality remain high and in light of the recent
through the reduction of neonatal tetanus. shift to skilled attendance at delivery—a distant
Combination of training with effective reality for some.
immunization programs would probably have
Available from:
considerable impact.
American College of Nurse Midwives
Department of Global Outreach
Sharma, N. and P. Bali. 1989. “Care of the 818 Connecticut Ave. NW, Suite 900
newborn by traditional birth attendants,” Washington, DC 20006
Indian Pediatr., vol. 26, no. 7, pp. 649–653. Email: dbond@acnm.org
121
4. Selected Issues Related to the
Newborn Infant
Care at Birth
Ansell, P., E. Roman, N. T. Fear, and M. J. in the current knowledge about the significance,
Renfrew. 2001. “Vitamin K policies and the related pathology and the possible strategies to
midwifery practice: questionnaire survey,” BMJ, prevent adverse fetal outcome. The acquired data
vol. 322, no. 7295, pp. 1148–1152. were used to propose some recommendations to
tackle this problem at district level.
Abstract: OBJECTIVES: To investigate policies on
neonatal vitamin K and their implementation.
DESIGN: Two phase postal survey. SETTING: Arteaga-Vizcaino, M., H. M. Espinoza, G. E.
United Kingdom. PARTICIPANTS: A 10% random Torres, M. Diez-Ewald, J. Quintero, G.
sample of midwives registered with the United Vizcaino, J. Estevez, and N. Fernandez. 2001.
Kingdom Central Council for nursing, midwifery, “Effect of oral and intramuscular vitamin K on
and health visiting. Of 3,191 midwives in the the factors II, VII, IX, X, and PIVKA II in the
sample, 2,515 (79%) responded to phase one and infant newborn under 60 days of age,” Rev.
2,294 (72%) completed questionnaires on their Med. Chil., vol. 129, no. 10, pp. 1121–1129.
current jobs (November 1998 to May 1999). In
phase two, 853 (62%) of 1,383 eligible midwives Abstract: BACKGROUND: Neonates on exclusive
gave details on 2,179 of their earliest jobs (start breastfeeding that do not receive vitamin K at birth
dates before 1990). RESULTS: All the midwives in are at higher risk hemorrhagic disease of the
clinical practice at the time of the survey newborn. AIM: To compare the effect of oral or
(2,271, 99%) reported that they were working in intramuscular administration of vitamin K1 (VK1),
areas with official policies on neonatal vitamin K. on clotting factors II, VII, IX, X and PIVKA II, in
Seven distinct policies were described: children until the 60 days of age with exclusive
intramuscular vitamin K for all babies breastfeeding or mixed feeding. PATIENTS AND
(1,159, 51.0%); intramuscular vitamin K for METHODS: Forty healthy full term infants,
babies at “high risk,” oral for others (470, 20.7%); distributed in two groups, A: 20 with mixed
oral vitamin K for all babies (323, 14.2%); feeding (formula-feeding and breastfeeding) and
parental choice for all (124, 5.5%); parental choice B: 20 with exclusive breastfeeding, were studied.
for all except babies at high risk, (119, 5.2%); Nine infants of each group received 1mg of VK1
intramuscular vitamin K for babies at high risk intramuscularly and eleven 2mg VK orally 5ml of
only (33, 1.5%); oral vitamin K for babies at high cord blood was collected initially from each infant.
risk only (17, 0.7%); and a disparate group of Venous blood samples were taken on 15, 30, and
policies including intravenous vitamin K for some 60 days of age. RESULTS: All factors increased in a
babies (26, 1.1%). Previous policies were (and progressive form reaching levels over 50% at 60
some may still be) open to individual interpretation days of age, in both groups. PIVKA II decreased
and were not always followed. CONCLUSIONS: significantly during the study period (p<0.01).
Hospital policy is not necessarily a good guide to Factor II increased more in children with mixed
individual practice. The primary purpose of clinical feeding that received intramuscular vitamin K, than
records is to document patient care, and recording in the rest of study groups. No other differences
practices reflect this. There is considerable between groups were observed. No infant had an
variation in vitamin K policies and midwifery abnormal bleeding during the study period.
practice in the United Kingdom, and there is no CONCLUSIONS: Oral administration of vitamin K
clear consensus on which babies should receive is as effective as the intramuscular route in the
vitamin K intramuscularly. prevention of the hemorrhagic disease of the
newborn.
125
infants to prevent hemorrhagic disease of the whether either hemorrhagic disease of the newborn
newborn (HDNB) and (2) the safest method, in or any unexplained intracranial hemorrhage
light of preliminary evidence suggesting that occurred in an infant who received orally
intramuscular administration of vitamin K is administered vitamin K, but none could be found
associated with childhood cancer. DATA in three separate databases. We conclude that we
SOURCES: A MEDLINE search of articles have met our duty of providing appropriate care.
published between January 1, 1991, and April 30,
1994, with the use of MeSH terms “hemorrhagic
disease of the newborn,” articles were limited to Grajeda, R., R. Perez-Escamilla, and K. G. Dewey.
those involving human subjects, from birth to 1997. “Delayed clamping of the umbilical cord
adolescence, and to articles from journals indexed improves hematologic status of Guatemalan
through Index Medicus and written in English. infants at 2 months of age,” Am. J. Clin. Nutr.,
References of all articles found through the initial vol. 65, no. 2, pp. 425–431.
search, the earliest of which was published in Abstract: Iron deficiency anemia is a serious health
1967, were also reviewed. STUDY SELECTION: problem that affects the physical and cognitive
Six controlled trials met the selection criteria: a development of children. Therefore, it is important
minimum four-week follow-up period, a minimum to develop cost-effective interventions to improve
of 60 subjects and a comparison of oral and the hematologic status of the millions of children
intramuscular administration or of regimens of affected by this condition worldwide. We studied
single and multiple doses taken orally. All 69 Guatemalan infants who had been randomly
retrospective case reviews were evaluated. Because assigned to one of three groups at the time of
of its thoroughness, the authors selected a meta- delivery: 1) cord clamping immediately after
analysis of almost all cases involving patients more delivery (n=21); 2) clamping when the cord
than seven days old published from 1967 to 1992. stopped pulsating, with the infant placed at the
Only five studies that concerned safety were found, level of the placenta (n=26); or 3) clamping when
and all of these were reviewed. DATA the cord stopped pulsating, with the newborn
EXTRACTION: In controlled trials, the risk of placed below the level of the placenta (n=22).
HDNB caused by vitamin K deficiency among Maternal and infant hematologic assessments were
infants receiving different regimens of vitamin K; in performed at the time of delivery and two months
case studies, method of vitamin K administration postpartum. At baseline the groups had similar
and incidence of hemorrhagic disease; and in
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
128
successful first step in the socialization process. Aspiration can occur in utero with fetal gasping, or
Exploring more deeply local perceptions explaining after birth with the first breaths of life. Many cases
the origin of the n g, the authors found an of MAS can be prevented by the strategies
interesting relationship with religious taboos. addressed in this article, but some will occur
Beside prohibited food, the n g are also due to despite appropriate preventive techniques. There is
transgression of various taboos surrounding birth not enough evidence to support the use of
and breastfeeding and even suggest a religious, amnioinfusion as a standard of care for all
rather than hygienic, explanation for the food pregnancies complicated by meconium. Pharyngeal
prohibited. DAE ultimately consists in re-adjusting suctioning before delivery of the shoulders is an
the child and his mother according to moral and effective preventive intervention, as is the
cultural rules, avoiding the negative consequences combination of pharyngeal suctioning followed by
of transgression. Consistently, DAE also facilitates intubation and tracheal suctioning. Suctioning of
the process of acquiring bio-social aptitudes for the the trachea may be done on a selective basis
child and therefore help him to enter his/her family depending on fetal vigor and consistency of
as a fully accepted member. Moreover, religious meconium.
prohibitions surrounding birth end as soon as the
child is able to eat solid food and free him/herself.
Therefore, DAE also helps the parents to get back McMillan, D. D. 1996. “Administration of
to their normal life conditions. In conclusion, in Vitamin K to newborns: implications and
addition to prophylactic and therapeutic recommendations,” CMAJ., vol. 154, no. 3,
explanations, the DAE participates in a general pp. 347–349.
process of socialization of newborns. To a certain Abstract: The review by Drs. Brousson and Klein
extent, the child’s health depends on the respect of (see pages 307 to 315 of this issue) identifies
the social and religious system and rules. The study controversies surrounding the administration of
reveals the important conceptual gap that may vitamin K to babies shortly after birth. Controlled
exist between two different logical frameworks— studies comparing the effect of oral and
biomedical and popular—prone to explain health intramuscular administration are unlikely to be
risk for newborns. The authors then reflect on the conducted because of the large number of subjects
possible impact of health education programs needed. The evidence presented in the review
seeking to intervene at the hygienic level and should dispel concerns that intramuscular
ultimately facing an important set of cultural administration may be associated with childhood
values aiming at keeping the social and cultural cancer. Oral administration of a single dose of
organization coherent. vitamin K soon after is associated with significant
biochemical vitamin K deficiency by one month of
age, but the relation of biochemical abnormality to
Klingner, M. C. and J. Kruse. 1999. “Meconium
clinical manifestations of late hemorrhagic disease
aspiration syndrome: pathophysiology and
of the newborn is less clear. Epidemiologic studies
prevention,” J. Am. Board Fam. Pract., vol. 12,
indicate a small, but significant, increase in the
no. 6, pp. 450–466.
incidence rate of hemorrhagic disease after oral
Abstract: BACKGROUND: Despite the common administration of vitamin K (1.0 to 6.4 incidents
occurrence of intrauterine meconium passage and per 1,000,000 infants), compared with the
resultant meconium aspiration syndrome (MAS), incidence rate after intramuscular administration
controversies regarding the pathophysiology and (0.25 incidents per 100,000 infants). Although
use of appropriate preventive strategies abound. repeated oral doses of vitamin K may be and
METHODS: Databases from MEDLINE, MD effective alternative regimen, there is no approved
Consult, and the Science Citation Index were oral vitamin K formulation, there are concerns
searched from 1964 to the present to find relevant about patient compliance, and there has been
sources of information. RESULTS AND limited investigation of such regimen. Therefore,
CONCLUSIONS: Meconium passage occurs by intramuscular administration of a single dose of
three distinct mechanisms: (1) as a physiologic 1.0mg of vitamin K shortly after birth is
CARE AT BIRTH
129
Abstract: Immediate clamping of the umbilical cord Abstract: Available at:
can reduce the red blood cells an infant receives at PATH
birth by more than 50%, resulting in potential 4 Nickerson Street
short-term and long-term neonatal problems. Cord Seattle, WA 98109-1699
clamping studies from 1980 to 2001 were Tel: 206-285-3500
reviewed. Five hundred thirty-one term infants in Web: http://www.path.org/materials-
the nine identified randomized and nonrandomized details.php?id=465
studies experienced late clamping, ranging from
three minutes to cessation of pulsations, without
symptoms of polycythemia or significant Puckett, R. M. and M. Offringa. 2000.
hyperbilirubinemia. Higher red blood cell flow to “Prophylactic vitamin K for vitamin K
vital organs in the first week was noted, and term deficiency bleeding in neonates,” Cochrane.
infants had less anemia at two months and Database. Syst. Rev., no. 4, p. CD002776.
increased duration of early breastfeeding. In seven Abstract: BACKGROUND: Vitamin K deficiency
randomized trials of preterm infants, benefits can cause bleeding in an infant in the first weeks of
associated with delayed clamping in these infants life. This is known as Hemorrhagic Disease of the
included higher hematocrit and hemoglobin levels, Newborn (HDN). HDN is divided into three
blood pressure, and blood volume, with better categories: early, classic and late HDN. Early HDN
cardiopulmonary adaptation and fewer days of occurs within 24 hours postpartum and falls
oxygen and ventilation and fewer transfusions outside the scope of this review. Classic HDN
needed. For both term and preterm infants, few, if occurs on days one to seven; common bleeding
any, risks were associated with delayed cord sites are gastrointestinal, cutaneous, nasal and from
clamping. Longitudinal studies of infants with a circumcision. Late HDN occurs from weeks
immediate and delayed cord clamping are needed. 2–12; the most common bleeding sites are
intracranial, cutaneous, and gastrointestinal.
Vitamin K is commonly given prophylactically after
Narayanan, I., A. Saili, and A. L. Khandara. 1989.
birth for the prevention of HDN, but the preferred
“Vitamin K for the newborn—old avenues
route is uncertain. OBJECTIVES: To review the
revisited,” Indian Pediatr., vol. 26,
evidence from randomized trials in order to
pp. 1229–1233.
determine the effectiveness of vitamin K
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
Abstract: While there have been controversies on prophylaxis in the prevention of classic and late
its use, the general consensus is to recommend the HDN. Main questions are: Is one dose of vitamin
use of intramuscular or oral.vitamin K. In K, given after birth, able to significantly reduce the
developing countries, the oral route has several incidence of classic and late HDN? Is there a
advantages provided the drug is available. significant difference between the oral route and
Breastfed babies in particular need vitamin K due the intramuscular route in preventing classic and
to the low content in human milk. In addition, the late HDN? Are multiple oral doses of vitamin K,
type of bacterial flora supported by breastmilk given after birth, able to significantly reduce the
does not produce much vitamin K. In communities incidence of classic and late HDN? SEARCH
with inadequate health care and poor hygiene and STRATEGY: The standard search strategy of the
where babies receive other liquids, the gut in Cochrane Neonatal Review Group was used.
breastfed babies may develop flora that produce SELECTION CRITERIA: All trials using random
more vitamin K. In poor communities and in or quasi-random patient allocation, in which
peripheral centers it may also be difficult to methods of vitamin K prophylaxis in infants were
administer vitamin in any form. However, as compared to each other, placebo or no treatment,
practices improve and more babies are on exclusive were included. DATA COLLECTION AND
breastfeeding, the need for vitamin K will not only ANALYSIS: Data were extracted independently by
become greater but such areas may be in a better each author and were analyzed with the standard
position to administer it. methods of the Cochrane Collaboration and its
Neonatal Review Group, using relative risk, risk
difference and weighted mean difference. MAIN
PATH/Kenya. 2000. A brief overview of the RESULTS: Two eligible randomized trials, each
purpose, development, and evaluation of clean comparing a single dose of intramuscular vitamin
delivery kits: delivery kit workshop manual. K with placebo or nothing, assessed effect on
clinical bleeding. One dose of vitamin K reduced
130
clinical bleeding at one to seven days, including births. Incidences in less developed countries may
bleeding after circumcision, and improved be much higher. Three incidence scenarios are
biochemical indices of coagulation status. Eleven proposed and the corresponding losses of
additional eligible randomized trials compared disability-adjusted life-years (DALYs) calculated.
either a single oral dose of vitamin K with placebo Under the intermediate scenario, late hemorrhagic
or nothing, a single oral with a single disease accounts for 0.1% to 0.2% of DALYs lost
intramuscular dose of vitamin K, or three oral to children less than 5 years of age. Assuming a
doses with a single intramuscular dose. None of cost of U.S. $1.00 per injection, each DALY saved
these trials assessed clinical bleeding. Oral vitamin would cost U.S. $133. Decisions on prophylaxis
K improved biochemical indices of coagulation must be made on a national basis, considering
status at one to seven days. There was no evidence mortality levels and causes, health budgets, and
of a difference between the oral and intramuscular feasibility. Comparison with the impact of diseases
route in effects on biochemical indices of prevented by breastfeeding shows that concern
coagulation status. A single oral compared with a with hemorrhagic disease should not affect
single intramuscular dose resulted in lower plasma breastfeeding promotion efforts, although strategies
vitamin K levels at two weeks and one month, for supplementing breastfed infants must be
whereas a 3-dose oral schedule resulted in higher explored.
plasma vitamin K levels at two weeks and at two
months than did a single intramuscular dose.
REVIEWER’S CONCLUSIONS: A single dose World Health Organization. 1997. Care in normal
(1.0mg) of intramuscular vitamin K after birth is birth: report of a technical working group.
effective in the prevention of classic HDN. Either Abstract: Establishes universal guidelines for the
intramuscular or oral (1.0mg) vitamin K routine care of women during uncomplicated labor
prophylaxis improves biochemical indices of and childbirth. Reflecting the consensus reached by
coagulation status at 1–7 days. Neither an international group of experts, the report
intramuscular nor oral vitamin K has been tested in responds to the recent proliferation of practices
randomized trials with respect to effect on late designed to start, augment accelerate, regulate or
HDN. Oral vitamin K, either single or multiple monitor the physiological process of labor in
dose, has not been tested in randomized trials for industrialized and developing countries alike.
its effect on either classic or late HDN. Recommendations for routine care are based on a
critical review of what considerable research has to
say about the effectiveness and safety of 59
Safe Motherhood Interagency Group. Skilled
common procedures and practices.
attendance at delivery: a review of the
evidence. Safe Motherhood—Family 1997–WHO/FRH/MSM/96.24
International (in press). 2000. Available in French
Abstract: In press (disseminated by Family Care Available at:
International on behalf of the Inter-Agency Group http://www.who.int/dsa/cat98/mat8.htm#Care in
for Safe Motherhood). Normal Birth
Victora, C. G. and P. Van Haecke. 1998. “Vitamin Zipursky, A. 1999. “Prevention of vitamin K
K prophylaxis in less developed countries: deficiency bleeding in newborns,” Br. J.
policy issues and relevance to breastfeeding Haematol., vol. 104, no. 3, pp. 430–437.
promotion,” Am. J. Public Health, vol. 88,
no. 2, pp. 203–209. Abstract: Newborn babies are born vitamin K
deficient; however, the deficiency is not sufficiently
Abstract: Vitamin K prophylaxis prevents severe to cause a vitamin K deficiency
hemorrhagic disease of the newborn. The present coagulopathy and hemorrhagic disease of the
review estimates the potential magnitude of this newborn (HDN). Severe vitamin K deficiency can
problem in less developed countries, assessing the develop quickly in breastfed newborns and can
CARE AT BIRTH
need for prophylaxis, along with its cost- result in the appearance of classic HDN during the
effectiveness and feasibility. Late hemorrhagic first week of life or late HDN during the first
disease, occurring between 2 and 12 weeks, often two months of life. Both forms of the disease can
leads to death or permanent disability. Its median be severe, causing brain damage and death. Classic
incidence in developed countries is 7 per 100,000 and late HDN are prevented by the intramuscular
131
administration of vitamin K at birth. Oral provides evidence that there is need for
prophylaxis prevents classic HDN but is ineffective intramuscular vitamin K prophylaxis for all babies
in preventing late HDN. Despite proven in order to eradicate hemorrhagic disease of the
effectiveness of intramuscular vitamin K newborn and concludes that there is no evidence
prophylaxis there have been concerns about the that this therapy is harmful.
need for, and safety of, this therapy. This review
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
132
Temperature Maintenance
Acolet, D., K. Sleath, and A. Whitelaw. 1989. sleep, whereas in term infants aged 36 to 72 hours
“Oxygenation, heart rate and temperature in (similar postconceptional age), an increased index
very low birthweight infants during skin-to-skin was observed during active sleep. CONCLUSION:
contact with their mothers,” Acta Paediatr. A mild increase in environmental temperature has
Scand., vol. 78, no. 2, pp. 189–193. an effect on breathing patterns in both preterm
(even when they have reached maturity) and term
Abstract: Fourteen very low birthweight infants
infants. However, a different response related to
were studied positioned either prone horizontal or
sleep state was observed in the two groups. We
skin-to-skin at 60 degree tilt between the mother’s
speculate that these effects may play a role in the
breasts. Heart rate, skin temperature and
association between a life-threatening event and
oxygenation by transcutaneous PO2 and pulse
elevated environmental temperature in both groups
oximetry were measured. Nine of the infants had
of infants.
normal lungs when studied. These infants showed
no change in tcPO2 or oxygen saturation but heart
rate increased significantly by a mean of 6.5 beats Bhargava, S. K., S. K. Mittal, S. Kumari, A.
per minute during skin-to-skin contact. Five infants Kumar, and S. Ghosh. 1977. “Heat injury in the
with chronic lung disease, including two on nasal newborn,” Indian J. Med. Res., vol. 65, no. 5,
catheter oxygen, showed a significant 1.0kPa rise pp. 688–695.
in tcPO2 during skin-to-skin contact. Back skin
temperature was well maintained during skin-to- Abstract: Heat injury due to prolonged exposure to
skin contact with the room temperature at 26 to excessively high environmental temperatures, a
29°C. None of the infants had a significant apnea previously unreported entity, in 52 neonates who
or bradycardia during the study. Stable very low were born at the hospital and sustained the disease
birthweight infants can enjoy such close contact during their stay in non-air conditioned wards, is
with their mothers and the tilted position may reported. The diagnostic criteria included the
improve pulmonary function in some cases. presence of high fever (>39.4°C) with or without
other symptoms and absence of clinical and
laboratory evidence to account for any other cause
Bader, D., E. Tirosh, H. Hodgins, M. Abend, and of the illness. The critical environmental
A. Cohen. 1998. “Effect of increased temperature which caused the syndrome was
environmental temperature on breathing 42.5°C or above. Two distinct clinical patterns
patterns in preterm and term infants,” J. were noted, one consisting of fever alone and the
Perinatol., vol. 18, no. 1, pp. 5–8. other which additional associated manifestations
such as weight loss, abdominal distension, cerebral
Abstract: OBJECTIVE: This study was done to
irritability, hypertonia and hemorrhagic diathesis.
evaluate the effect of an increase in environmental
The heat injury seemed to cause widespread
temperature in healthy infants on breathing
pathological changes and affected mainly the
patterns during sleep. STUDY DESIGN: Ten
central nervous system, liver and kidney. Significant
preterm infants (mean gestational age 30.6 [SD
biochemical alterations included hypo and
1.5] weeks) who reached maturity and 10 term
hypernatraemia and hypo and hyperchloremia.
comparison infants underwent polysomnographic
TEMPERATURE MAINTENANCE
133
Abstract: Cleaning newborn infants with coconut Choudhary, S. P., R. K. Bajaj, and R. K. Gupta.
oil shortly after birth is a common practice in 2000. “Knowledge, attitude and practices about
Malaysian labor rooms. This study aimed: (1) to neonatal hypothermia among medical and
determine whether this practice was associated paramedical staff,” Indian J. Pediatr., vol. 67,
with a significant decrease in the core temperature no. 7, pp. 491–496.
of infants; and (2) to identify significant risk
Abstract: The present study was undertaken to
factors associated with neonatal hypothermia. The
evaluate the knowledge, attitude and practices
core temperature of 227 randomly selected normal-
about neonatal hypothermia among medical and
term infants immediately before and after cleaning
paramedical staff dealing with newborn care. A
in labor rooms was measured with an infrared
total of 160 subjects were assessed (40 pediatric
tympanic thermometer inserted into their left ears.
medicine residents, 40 obstetric residents,
Their mean post-cleaning body temperature
40 private practitioners and 40 paramedical staff
(36.6°C, SD=1.0) was significantly lower than their
working in labor room and postnatal wards). A
mean pre-cleaning temperature (37.1°C, SD=1.0;
pre-tested structured questionnaire was used. Only
p<0.001). Logistic regression analysis showed that
47.8% of the subjects defined neonatal
the risk factors significantly associated with pre-
hypothermia correctly. As many as 52.2% of the
cleaning hypothermia (<36.5°C) were: (1) not
interviewees considered it to be an uncommon
being placed under radiant warmer before cleaning
problem. Lethargy, refusal for feed and cold to
p=0.03); and (2) lower labor room temperature
touch were mentioned as common symptoms of
(p<0.001). Logistic regression analysis also showed
neonatal hypothermia by 97.5%, 80%, and 77.5%
that the risk factors significantly associated with
of the respondents respectively. Decreased body
post-cleaning hypothermia were: (1) lower labor
temperature, cyanosis, apnea and edema of feet
room temperature (p<0.001); (2) lower pre-
were found as common signs. Only 18.6% of the
cleaning body temperature (p<0.001); and (3)
interviewees had knowledge about correct method
longer duration of cleaning (p=0.002). In
of recording the temperature in a newborn. The
conclusion, to prevent neonatal hypothermia, labor
present study reveals the gross lacunae in the
room temperature should be set at a higher level
knowledge regarding various aspects of neonatal
and cleaning infants in the labor room should be
hypothermia among pediatric and obstetric
discouraged.
residents and paramedical staff working in labor
room and postnatal wards. To reduce the neonatal
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
Chen, C. H., T. M. Wang, H. M. Chang, and C. S. morbidity and mortality due to neonatal
Chi. 2000. “The effect of breast- and bottle- hypothermia, greater emphasis should be laid on
feeding on oxygen saturation and body this problem while designing curriculum for
temperature in preterm infants,” J. Hum. Lact., training of undergraduate and postgraduate
vol. 16, no. 1, pp. 21–27. doctors, paramedical staff and traditional birth
attendants.
Abstract: From July 1997 to June 1998,
25 preterm infants (birthweight <1,800g) were
included in a prospective study to compare the Christensson, K., A. B. Ransjo-Arvidson, C.
clinical effects of breast- and bottle-feeding. Kakoma, F. Lungu, G. Darkwah, D.
Oxygen saturation, heart rate, respiratory rate, and Chikamata, and G. Sterky. 1988. “Midwifery
body temperature were recorded every minute for care routines and prevention of heat loss in the
20 minutes during feeding periods. Eighty pairs of newborn: a study in Zambia,” J. Trop. Pediatr.,
breast- and bottle-feeding sessions were observed at vol. 34, no. 5, pp. 208–212.
the chronological age of 9.3 +/– 4.3 weeks (range =
Abstract: A number of midwifery practices might if
2.1–25.3 weeks). Oxygen saturation and body
properly applied prevent unnecessary heat loss in
temperature of the preterm infants were
the newborn. The care of 62 normal newborns was
significantly higher when they were directly
observed following birth at four levels of
breastfed. There were two episodes of apnea
institutions, the majority being at the University
(breath pause more than 20 seconds) and 20
Teaching Hospital in Lusaka. At discharge after an
episodes of oxygen desaturation (PaO2<90%)
average of 14 hours, half the babies had a body
during bottle-feeding and none during
temperature below 36°C, i.e., mildly hypothermic.
breastfeeding. We conclude that breastfeeding is a
There was a significant decrease in body
more physiological feeding method for the preterm
temperature between 30 and 120 minutes
infant and bottle-feeding may be more stressful.
postpartum. Proper wiping and wrapping of the
134
babies was rarely carried out. Unnecessary seven days) were less likely to be hypothermic at
separation of babies from their mothers and no admission. “Hypothermia” was not recorded as an
extra provision of heat during suction at the admission diagnosis and no special attention was
resuscitation table were common. Among both given to those infants in terms of clinical
mothers and staff there was a lack of management. Mean time to reach a body
understanding of the newborns’ non-shivering temperature above 35.9°C did not differ between
thermogenesis. Traditional practices were often infants kept in a cot and in an incubator. Total
more appropriate than so-called modern. number of deaths was 82 (31%) and the mortality
Midwifery education did not positively affect was higher in infants who were hypothermic at
practices. With available resources it should be admission compared to those who were not. This
possible to limit neonatal heat loss. study demonstrates that a change of existing care
routines is needed.
Abstract: A prospective cohort study was carried Systems, Carlsbad, CA) infrared thermometer in
out at the University Teaching Hospital, Lusaka, the cal-tympanic mode. Rectal, inguinal, and
Zambia, to investigate the prevalence of neonatal axillary temperatures were collected with an IVAC
hypothermia, type of infant care and incidence of digital thermometer (San Diego, CA) in the
mortality. Two-hundred-and-sixty-one infants, aged predictive mode. There were moderate correlations
0–7 days, admitted to the pediatric unit during the between the body site temperatures. The
“warm” season were recruited to the study. Forty- environment significantly influenced temperature
four percent of the infants were hypothermic readings at the different sites. Temperatures
(<36°C) on admission, and admission hypothermia assessed in the superheated environments of the
correlated to admission weight and home delivery radiant warmer and the incubator were
in the youngest age group (0–24 hours). consistently higher than temperatures in the
Exclusively breastfed infants (age group one to bassinet.
135
Daga, S. R., D. Sequera, S. Goel, B. Desai, and A. 30 minutes after the feed in babies not receiving
Gajendragadkar. 1996. “Adequacy of solar oxygen and at 20 and 30 minutes after feeds in
energy to keep babies warm,” Indian Pediatr., babies receiving oxygen.
vol. 33, no. 2, pp. 102–104.
Abstract: OBJECTIVE: Solar energy could be used Dragovich, D., G. Tamburlini, A. Alisjahbana, R.
as an alternate energy source for keeping neonates Kambarami, J. Karagulova, O. Lincetto, D. S.
warm especially in tropical countries. The present Malla, M. J. Mello, and N. S. Vani. 1997.
study investigated the efficacy of solar powered “Thermal control of the newborn: knowledge
room heating system. SETTING: Referral center and practice of health professional in seven
for neonatal care. INTERVENTION: A fluid countries,” Acta Paediatr., vol. 86, no. 6,
system heated by solar panels and circulated into a pp. 645–650.
room was used to maintain room temperature. A
servocontrolled heating device was used to regulate Abstract: Hypothermia is a common problem in
and maintain desired room temperature. MAIN neonates, particularly in developing countries
OUTCOME MEASURES: Neonatal rectal where it is an important contributory factor to
temperature and room temperature. RESULT: neonatal mortality and morbidity. An evaluation
Infants between 1,750g–2,250g were observed to of the knowledge and practices of health
require a mean room temperature of 32.5°C to professionals on the thermal control of newborns
maintain normothermia. In 85 infants less than was carried out in seven countries: Brazil, India,
1,500g, of the 5,050 infant temperature records, Indonesia, Kazakhstan, Mozambique, Nepal and
only 3% showed a record less than 36°C. Zimbabwe. The evaluation, conceived as a
CONCLUSIONS: Solar powered room heating is preliminary phase for a one-day training course on
effective in maintaining infant temperature and is thermal control, involved 28 health facilities and
cost-effective as compared to the existing warming 260 health professionals (61 doctors and
devices. 199 nurses and midwives). It included an
assessment of thermal control practices carried out
in each health facility by external investigators and
Daga, S. R., L. Chandrashekhar, P. P. Pol, and S. a questionnaire on knowledge about
Patole. 1986. “Appropriate technology in thermoregulation administered to health
keeping babies warm in India,” Ann. Trop. professionals involved in newborn care. The
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
Paediatr., vol. 6, no. 1, pp. 23–25. findings of the evaluation were consistent across
countries and showed that thermal control
Abstract: Provision of a thermoneutral
practices were frequently inadequate in the
environment to the newborns has made an
following areas: ensuring a warm environment at
important contribution to improved neonatal
the time of delivery; initiation of breastfeeding and
survivals. Modern systems which only warm one
contact with mother, bathing; checking the baby’s
baby are expensive and their maintenance not very
temperature; thermal protection of low
easy. Warming a room with three to four babies by
birthweight babies, and care during transport.
means of simple devices is cost-effective and should
Knowledge on thermal control was also
be preferred by those to whom cost matters very
insufficient, especially concerning the physiology
much.
of thermoregulation and criteria for defining
hypothermia. During the one-day course that
Daga, S. R., V. K. Ahuja, and N. G. Lunkad. 1998. followed the evaluation, participants were able to
“A warm touch improves oxygenation in recognize the existing gaps and to identify
newborn babies,” J. Trop. Pediatr., vol. 44, appropriate interventions. Knowledge and practice
no. 3, pp. 170-172. on the thermal control of the newborn are
currently insufficient. However, awareness of the
Abstract: Oxygen saturation was studied in eight importance of thermal control and basic
newborn babies, seven preterm and one term, knowledge on thermal regulation and thermal
with and without caressing by the mother while protection can be easily acquired and on this basis
receiving gavage feeds. The babies were stable motivation for improving thermal control practices
with regard to cardiorespiratory and neurological can be developed.
status. Four babies were still receiving head-box
oxygen. The oxygen saturation levels were similar
before feeds. However, the levels were
significantly higher with caressing at 10, 20, and
136
Ellis, M., N. Manandhar, U. Shakya, D. S. Abstract: This prospective study compared
Manandhar, A. Fawdry, and A. M. Costello, standard newborn care under radiant heat with
1996, “Postnatal hypothermia and cold stress two methods of warming babies that provided
among newborn infants in Nepal monitored by immediate parent-infant contact. Fifty-one mother-
continuous ambulatory recording,” Arch. infant dyads were randomly assigned to three
Dis.Child Fetal Neonatal Ed., vol. 75, no. 1, treatment groups. Control group babies had no
pp. F42–F45. skin-to-skin contact with their mothers during the
study period. One group of experimental infants
Abstract: OBJECTIVES: To describe the pattern of
began skin-to-skin contact after completion of
hypothermia and cold stress after delivery among a
initial nursing care in a radiant heater. The second
normal neonatal population in Nepal; to provide
group of experimental babies had the earliest, most
practical advice for improving thermal care in a
continuous skin-to-skin contact with their mothers
resource limited maternity hospital. METHODS:
and were never under radiant heat. Skin
The principal government funded maternity
temperatures of all 51 newborns were noted every
hospital in Kathmandu, Nepal, with an annual
3 minutes for 45 minutes using an electronic
delivery rate of 15,000 (constituting 40% of all
thermometer. Rectal temperatures were also taken
Kathmandu Valley deliveries), severe resource
at 21 and 45 minutes after birth. Results supported
limitations (annual budget £250,000), and a cold
the hypothesis that body temperatures would be
winter climate provided the setting. Thirty-five
warmest in experimental babies given the earliest
healthy term neonates not requiring special care
skin-to-skin contact, less warm in experimental
were enrolled for study within 90 minutes of birth.
infants beginning skin-to-skin contact after initial
Continuous ambulatory temperature monitoring,
nursing care, and coolest in control babies given no
using microthermistor skin probes for forehead and
skin-to-skin contact with their mothers (p<0.001).
axilla, a flexible rectal probe, and a black ball
Significantly more control than experimental
probe placed next to the infant for ambient
newborns had skin and rectal temperatures below
temperature, was carried out. All probes were
the neutral thermal range at 21 and 45 minutes of
connected to a compact battery powered Squirrel
life. High delivery room temperature and drying
Memory Logger, giving a temperature reading to
babies well immediately after birth did not differ
0.2°C at 5-minute intervals for 24 hours. Severity
significantly among the three groups, but were
and duration of hypothermia, using cutoff values
found to be positively correlated with neonatal
of core temperature less than 36°C, 34°C, and
body temperature for the sample as a whole.
32°C; and cold stress, using cutoff values of skin-
core (forehead-axilla) temperature difference
greater than 3°C and 4°C were the main outcome Flenady, V. J. and P. G. Woodgate. 2002. “Radiant
measures. RESULTS: Twenty four hour mean warmers versus incubators for regulating body
ambient temperatures were generally lower than temperature in newborn infants (Cochrane
the WHO recommended level of 25°C (median Review),” Cochrane. Database. Syst. Rev.,
22.3°C, range 15.1°C–27.5°C). Postnatal no. 2, p. CD000435.
hypothermia was prolonged, with axillary core
temperatures only reaching 36°C after a mean of Abstract: BACKGROUND: The provision of a
6.4 hours (range 0–21.1; SD: 4.6). There was thermoneutral environment is an essential
persistent and increasing cold stress over the first component of the immediate and longer term care
24 hours with the core-skin (axillary-forehead) of newborn infants. A variety of methods are
temperature gap exceeding 3°C for more than half currently employed including incubators and open-
care systems, with or without modifications such as
TEMPERATURE MAINTENANCE
of the first 24 hours. CONCLUSIONS: Continuous
ambulatory recording identifies weak links in the heat shields and plastic wrap. The system used
“warm chain” for neonates. The severity and must allow ready access to the infant but should
duration of thermal problems was greater than also minimize alterations in the immediate
expected even in a hospital setting where some of environment. OBJECTIVES: To assess the effects of
the WHO recommendations had already been radiant warmers versus incubators on neonatal
implemented. fluid and electrolyte balance, morbidity and
mortality. SEARCH STRATEGY: The standard
search strategy of the Cochrane Neonatal Review
Fardig, J. A. 1980. “A comparison of skin-to-skin Group was used. This included searches of
contact and radiant heaters in promoting electronic databases: Oxford Database of Perinatal
neonatal thermoregulation,” J. Nurse Trials, Cochrane Controlled Trials Register
Midwifery, vol. 25, no. 1, pp. 19–28. (Cochrane Library Issue 4 2001), MEDLINE
137
(1966–2001), and CINAHL (1982–2001). as a potentially simpler and affordable alternative.
SELECTION CRITERIA: Randomized or quasi- METHODS: In a neonatal care ward of a referral
Randomized trials in which radiant warmers were hospital in Addis Ababa, 62 newborns <1 week
compared to incubators in a neonatal population. old, weighing 1,000g–1,999g, who were well
DATA COLLECTION AND ANALYSIS: enough to breathe comfortably in room air and
Independent data extraction and quality assessment tolerate oral feeds, were randomly allocated to
of included trials was conducted by the authors. INC, HWM or SHR and followed for three weeks.
Data were analyzed using relative risk (RR) and The level of cold stress as assessed by core-to-skin
weighted mean difference (WMD). Results are temperature gradient and the rate of weight gain
presented with 95% confidence intervals. Meta- were the main outcome measures. RESULTS: The
analysis was undertaken using a fixed effect model. level of cold stress was lowest in the INC,
MAIN RESULTS: Eight studies are included in this intermediate in the HWM and highest in the SHR.
review; six employed a crossover design. In the Relative to the INC group, the HWM group
overall comparison of radiant warmers vs. exhibited a modest increase in the occurrence of
incubators, radiant warmers caused a statistically clinically important hyperthermic or hypothermic
significant increase in insensible water loss (IWL) deviations in core temperature (rate ratio
[WMD 0.94g/Kg/day (95% CI: 0.47, 1.41)] and a (RR)=2.3; 95% CI: 0.9, 5.6), and the SHR
trend towards increased oxygen consumption displayed a definite increase (RR=4.0; 95% CI: 1.7,
which was not statistically significant [WMD 9.3). During the first week, the rate of weight gain
0.27mL/kg/min (95% CI: –0.09, 0.63)]. Due to was highest in the INC group (3.6g/kg/day), lowest
small numbers, effects on important clinical in the SHR group (–2.3g/kg/day, P<0.05 versus
outcomes could not be adequately assessed. A INC) and intermediate in the HWM group
comparison of radiant warmers with heat shields (1.6g/kg/day, P>0.1 versus INC). CONCLUSION:
vs. incubators without heat shields showed a trend Care in the SHR produced clinically significant
for increased IWL in the radiant warmer group, thermal stresses and was associated with deficient
which was not statistically significant. No early neonatal growth, but the use of HWM may
difference was shown in oxygen consumption. constitute a feasible and clinically acceptable
REVIEWER’S CONCLUSIONS: Radiant warmers alternative in providing warmth to LBW newborns
result in increased IWL compared to incubators. during the neonatal period.
This needs to be taken into account when
calculating daily fluid requirements. The results of
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
this review do not provide sufficient evidence Jansson, U. M., T. Mustafa, M. A. Khan, B. S.
concerning effects on important outcomes to guide Lindblad, and A. M. Widstrom. 1995. “The
clinical practice. Further Randomized controlled effects of medically-orientated labour ward
trials are required to assess the effects of radiant routines on prefeeding behaviour and body
warmers versus incubators in neonatal care on temperature in newborn infants,” J. Trop.
important short and long term outcomes, with Pediatr., vol. 41, no. 6, pp. 360–363.
particular attention to extremely low birthweight Abstract: The effects of medically-orientated labor
infants in the early neonatal period. ward routines were studied during the the first
hour after birth, in 48 vaginal, single deliveries. All
infants were immediately separated from their
Green-Abate, C., N. Tafari, M. R. Rao, K. Yu, and
mothers and left on a resuscitation table. There
J. D. Clemens. 1994. “Comparison of heated
was no significant difference in onset of crying if
water-filled mattress and space-heated room
the infant received cutaneous stimulation or not. It
with infant incubator in providing warmth to
was found that 17 infants, not showing hand-to-
low birthweight newborns,” Int. J. Epidemiol.,
mouth activity, were bathed at an average time of
vol. 23, no. 6, pp. 1226–1233.
17 minutes (12–23 minutes) after birth, while those
Abstract: BACKGROUND: Prevention of excessive who did were bathed at 28.5 (24.5–41.5) minutes
heat loss is fundamental to survival of low (P=0.002). One infant was breastfed during the
birthweight (LBW) newborns. The use of infant first hour. Being separated from its mother, bathed
incubators (INC) is beyond the resources of early, and swaddled after birth seemed to interfere
developing countries, and the space-heated room with the infant’s inborn ability to signal hunger.
(SHR) has been the only feasible means of Forty-one infants were hypothermic at one hour.
providing thermal protection to LBW newborns. According to a multiple regression analysis, infant
Recently a thermostatically controlled, heated, body temperature at 60 minutes of age
water-filled mattress (HWM) has been developed corresponded positively with birthweight
138
(P=0.0001) and time of oxygen administration Overall, 38% (114/298) of the infants had
(P=0.0002). A plausible explanation for the effect temperatures <36°C at 2 hours and 18% (41/231)
of oxygen exposure is that there is brown fat at 24 hours (when none was <35°C).
inactivation in normal newborn infants and
administration of oxygen activates the brown fat. It
might be advantageous to let the mother keep the Kumar, R. and A. K. Aggarwal. 1998. “Body
baby warm, rather than manipulate the baby’s temperatures of home delivered newborns in
metabolism with oxygen. north India,” Trop. Doct., vol. 28, no. 3,
pp. 134–136.
Abstract: In this prospective study, axillary
Ji, X. C., C. Y. Zhu, and R. Y. Pang. 1993.
temperature of newborns delivered at home were
“Epidemiological study on hypothermia in
recorded by a field worker once within a period of
newborns,” Chin. Med. J. (Engl.), vol. 106,
24 hours after the birth in ten villages of Haryana,
no. 6, pp. 428–432.
India, during 1992–1993. Room air temperature
Abstract: A study on the incidence and high risk was measured at the same time. Family members
factors of hypothermia in the newborn was carried were interviewed to record newborn care practices.
out in a period of four months (November Of the 189 babies, 11.1% were found to be
1988–February 1989) in six counties of three hypothermic (temperature <35.6°C) and 22.8%
provinces. Totally 14,809 newborns were studied, were hyperthermic (temperature >37.3°C). During
in whom 100 cases were found to be ill with the winter months, 19.1% were hypothermic as
sclerema, having an incidence of 6.7%. Gestational compared to only 3.1% in summer; 8.5% were
age, body weight, low room temperature, improper hyperthermic in winter compared to 36.8% in
methods of thermopreservation during delivery and summer. Room air temperature of <24°C was
asphyxia are determined as the most probable high recorded in 41%. A strong correlation was
risk factors, in which gestational age and body observed between room air temperature and
weight are negatively correlated with the neonatal temperature. At the time of birth, 13.2%
contraction of the disease. It suggests that the of the delivery rooms in summer and 73.6% in
prevention of prematurity and asphyxia, and winter were reported to have a heat source: 58.2%
promotion of thermopreservation during delivery babies were reported to be wiped soon after birth;
should be helpful in preventing sclerema of 97.3% were wrapped in cloth; the head was
newborns. covered in 59.1% cases in winter and 10.5% in
summer; 97.3% babies were kept with mother in
same bed but not in skin-to-skin contact; and 65%
Johanson, R. B., S. A. Spencer, P. Rolfe, P. Jones, were bathed within 24 hours after delivery.
and D. S. Malla. 1992. “Effect of post-delivery Neonatal hypothermia is a common problem in
care on neonatal body temperature,” Acta. developing countries. It is important that
Paediatr., vol. 81, no. 11, pp. 859–863. information, education and communication
Abstract: A prospective observational study of post- strategy about appropriate technologies for
delivery care and neonatal body temperature, prevention and management of neonatal
carried out at Kathmandu Maternity Hospital, was hypothermia is provided at domiciliary level. A
followed by a randomized controlled intervention significant proportion of babies are likely to suffer
study using three simple methods for maintaining from hyperthermia in warm countries, specially in
body temperature. There were 500 infants in the summer. Therefore, guidelines for thermal control
initial observation study and 300 in the intervention in home births should be tailored to the specific
TEMPERATURE MAINTENANCE
139
babies were missed by all of them. However, their (5cm beyond the anus, with an electronic
perception of moderate hypothermia was better. As telethermometer), rectum (2cm, with a mercury-in-
none of the babies in this study had severe glass thermometer), axilla, and between the skin
hypothermia, mothers’ and field workers’ ability to and mattress. Temperatures measured at the four
detect severe hypothermia by touch could not be sites agreed closely in this group of largely
evaluated. However, perception of mothers and normothermic infants. However, five of seven term
field workers was observed to be better as the infants with abnormal core temperature (greater
temperature of the baby decreased (mothers and than 1.5SD below or above the mean) would have
field workers had correctly detected two babies as been judged to be normothermic by each of the
“cold” who had temperature between 32.0°C and three other measurements. The temperatures in
32.9°C). Research assistants in a Kathmandu preterm infants were lower and varied less with the
Maternity Hospital could correctly perceive site of measurement, indicating a smaller core-
temperature by touching the foot of the baby in surface temperature gradient because of their
81% of the cases who had rectal temperatures of relative lack of thermal insulation by body fat.
<36°C. A good correlation has also been reported Axillary temperature was as reliable as rectal
between physicians’ perceptions of temperature by temperature measured in the usual way with a
touching the abdomen and foot with values mercury-in-glass thermometer. Measurement of the
recorded with a digital thermometer. A study, temperature between the skin and mattress was
therefore, needs to be done to determine if training nearly as accurate as the other more frequently
mothers and field workers can improve their ability used methods. Ninety percent of temperatures were
to identify hypothermic babies by human touch within 0.1°C of their final stabilization readings by
without using a thermometer. five minutes for each type of thermometer and
measurement site.
likelihood ratio of a low cost liquid crystal strip Abstract: OBJECTIVE: To determine whether there
thermometer (LCT) compared with axillary is a significant difference between the temperatures
mercury thermometry for the detection of neonatal of very low birthweight (VLBW) premature infants
hypothermia in Nepal. The subjects were in the incubator and in the mothers’ arms.
76 healthy newborns in the government maternity DESIGN: Repeated measures, with random
hospital of Kathmandu, Nepal in winter. The assignment to treatment order and the infants
validity of LCT for the detection of neonatal serving as their own controls. SETTING: A 40-bed
hypothermia (less than 36°C) showed a sensitivity tertiary-level nursery in a university teaching
of 83%, specificity 96%, positive predictive value hospital. PARTICIPANTS: A convenience sample of
98% and a likelihood ratio of 23. Use of LCT on 20 preterm infants weighing 1,095g to 1,500g and
newborns in this setting raises a measured pretest from 30 weeks to 37 weeks postconceptional age.
probability of first day hypothermia of 63% to a The infants were screened for factors that would
post-test probability of 97%. Liquid crystal interfere with temperature maintenance. MAIN
thermometry is a simple, low-cost, and valid OUTCOME MEASURES: Axillary temperatures
method for identifying core hypothermia in were measured with an electronic thermometer for
newborns. It is ideal for isolated rural communities equal periods of time in incubators and mothers’
where LCT strips could be added to delivery kits. arms. The mean temperature differences between
the two study conditions were compared using two-
tailed t tests and repeated analysis of variance
Mayfield, S. R., J. Bhatia, K. T. Nakamura, G. R. (ANOVA). Weight was monitored and analyzed for
Rios, and E. F. Bell. 1984. “Temperature evidence of increased metabolic activity. RESULTS:
measurement in term and preterm neonates,” J. No significant variations were found in the infants’
Pediatr., vol. 104, no. 2, pp. 271–275. mean temperatures in the incubator, but the infants
Abstract: Body temperatures of 99 term and 44 were significantly warmer while in their mothers’
preterm infants were measured at four sites: core arms. CONCLUSION: VLBW premature infants
can maintain a stable temperature in their mothers’
140
arms without evidence of increased metabolic polycythemia, need for tube feeding, phototherapy
activity. Nurses can encourage mothers to hold their and oxygen therapy, also did not differ between the
infants without fear of cold stress or weight loss. two groups. CONCLUSIONS: Early bathing,
minutes after birth, did not appear to adversely
affect the adaptation of healthy full-term and near-
Nako, Y., A. Harigaya, T.Tomomasa, A. term newborn infants.
Morikawa, M. Amada, C. Kijima, and S.
Tsukagoshi. 2000. “Effects of bathing Note: This applies only if the water and
immediately after birth on early neonatal environment is warm and specific care is taken to
adaptation and morbidity: a prospective keep the baby warm with quick drying and
randomized comparative study,” Pediatr. Int., appropriate wrapping—and where necessary, skin
vol. 42, no. 5, pp. 517–522. to skin contact. Such conditions may be difficult to
provide in a developing country—especially at the
Abstract: OBJECTIVE: Because the risks and community level.
benefits of early bathing of newborn infants are
not well established, we investigated the effects of
bathing immediately after birth on rectal Sarman, I., G. Can, and R. Tunell. 1989.
temperature, respiratory rate, heart rate, blood “Rewarming preterm infants on a heated, water
pressure, percutaneous arterial blood oxygen filled mattress,” Arch. Dis. Child, vol. 64,
saturation (SpO2) and early neonatal morbidity. no. 5, pp. 687–692.
METHODS: The study was designed as a
Abstract: Sixty low birthweight infants
randomized prospective comparative study in the
(1,000g–2,000g) admitted to a neonatal care unit
neonatal care unit of a university hospital. A total
in Turkey were studied. Those not requiring
of 187 healthy term and near-term newborn
intensive care were randomly assigned for
infants, who were delivered vaginally without
treatment either in a cot on a heated, water filled
asphyxia, between January and December 1997
mattress kept at 37°C (n=28) or in air heated
were the study subjects. We compared findings in
incubators with a mean air temperature of 35°C
newborns who were bathed 2–5 minutes after birth
(n=32). On admission 53 (88.3%) of the infants
(n=95) with those of a control group (n=92) who
had body temperatures between 30°C and 36°C.
received dry care instead. Groups were comparable
There was good correlation between axillary and
with respect to gestational age, birthweight, male:
rectal temperatures in the infants while they were
female ratio, Apgar score and umbilical blood pH.
hypothermic. Normal temperatures were achieved
Rectal temperature was measured with an
within the first day and remained within this range
electronic thermometer immediately before the
during the subsequent days after admission in all
intervention bathing or dry care and at 30 minutes
the infants treated on the heated, water filled
and 1, 2, 3, 8, and 12 hours after birth. Heart rate,
mattress, whereas they were not achieved until
respiratory rate, systolic and diastolic blood
three days later in the incubator group. The
pressure and SpO2 were measured at 1, 2, 8, and
neonatal mortality among those treated on the
12 hours after birth. The incidence of early
heated, water filled mattress was 21%, and among
neonatal morbidity, including hyperbilirubinemia
those treated in the incubator 34%. The heated,
and gastrointestinal and respiratory problems, was
water filled mattress provides a good alternative to
also compared. RESULTS: Rectal temperature
skin to skin contact with the mother, and to the use
changed over time postnatally in both groups
of a complex and expensive incubator for rapidly
(P<0.0001, ANOVA) and there was a significant
attaining and maintaining normal temperatures in
difference in rectal temperature between groups
TEMPERATURE MAINTENANCE
the low birthweight newborn.
(P<0.0001, ANOVA). Mean (+/– SEM) rectal
temperature at 30 minutes after birth (i.e.,
approximately within 20 minutes after Singh, M., G. Rao, A. K. Malhotra, and A. K.
intervention) was significantly higher in the bathed Deorari. 1992. “Assessment of newborn baby’s
group than in the control (dry care) group (37.30 temperature by human touch: a potentially
+/– 0.06°C vs. 37.00 +/– 0.05°C, respectively; useful primary care strategy,” Indian Pediatr.,
P=0.000022). Respiratory rate, heart rate, blood vol. 29, no. 4, pp. 449–452.
pressure and the ratio of the number of infants
with SpO2 90%–94% and 95%–100% did not Abstract: Fifty healthy term neonates delivered at
differ significantly between the two groups. The All India Institute of Medical Sciences Hospital
incidence of early neonatal morbidity, including were assessed by three pediatricians for skin
vomiting, acute gastric mucosal lesion, temperature to the nearest +/– 0.5°C at the three
body sites, i.e., mid-forehead, abdomen and
141
dorsum of right foot by touch. The predicted with hypothermia. LCTs were 38.5% sensitive and
temperatures at different sites were compared with 100% specific for detecting fevers. These results
simultaneously recorded temperatures at the same suggest that LCTs leave undetected a large
sites with the help of an electronic thermometer proportion of children who have fevers. However,
having a sensitivity of +/– 0.1°C. Rectal they are sensitive for identifying children with
temperature was also recorded in all the babies hypothermia. A knowledge, attitude and practice
with a rectal thermister to compare the variations (KAP) study indicated that local mothers can be
between the core and skin temperatures. There was identified who understand principles and
a good correlation between the skin temperatures procedures of LCTs, and accept them for health
of the babies as perceived by touch and values care of their child.
recorded with the help of an electronic
thermometer. All the hypothermic babies were
correctly picked up by all the observers. There was van den Bosch, C. A. and C. H. Bullough. 1990.
good correlation between core temperature and “Effect of early suckling on term neonates’ core
skin temperature at different sites except forehead. body temperature,” Ann. Trop. Paediatr.,
It is amazing that even during the month of May, vol. 10, no. 4, pp. 347–353.
when ambient temperature was maintained Abstract: The purpose of this study was to
between 26°C–28°C, nearly one-fifth of the healthy determine whether the practice of early suckling,
term babies were under cold stress as evidenced by through an effect on maternal behaviour, would
greater than 2°C difference between the core and improve neonatal temperature control. One
peripheral skin temperatures. It is recommended hundred and sixty mothers having daytime
that health professionals and mothers should be spontaneous deliveries of healthy babies at term
explained the importance of evaluating the core were randomized into two groups. The treatment
and peripheral skin temperature by touch for early group were encouraged to put the baby to the
identification of babies under cold stress in order breast immediately after delivery. In the control
to prevent occurrence of life threatening group, the baby was placed in a cot immediately
hypothermia. after birth and breastfeeding occurred some time
later at a time of the mother’s choice. Observations
of the mother’s behaviour towards her baby and
Valadez, J. J., M. Elmore-Meegan, and D. Morley.
the baby’s core body temperature were recorded at
1995. “Comparing liquid crystal thermometer
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
142
hyperthermia are detailed, along with strategies to Or mail, fax, or email the request and order to:
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TEMPERATURE MAINTENANCE
143
Cord Care
Andrich, M. P. and S. M. Golden. 1984. disinfectants do not offer any advantage. However,
“Umbilical cord care. A study of bacitracin cleaning the umbilical cord with disinfectants may
ointment vs. triple dye,” Clin. Pediatr. (Phila.), reduce the risk of serious bacterial infections in
vol. 23, no. 6, pp. 342–344. babies in poor countries or in neonatal wards.
Observational studies in poor countries indicate
Abstract: Umbilical cord colonization rates were
that the life of numerous infants can be saved if
examined over a four-year period following topical
pregnant women are vaccinated against tetanus
application of bacitracin (1978–1980) or triple dye
and disinfectants are substituted for harmful cord
(1980–1982). A total of 2,402 cords were cultured:
care traditions. This Cochrane review is credible,
1,229 following bacitracin cord care and
but it should be updated and considered tentative
1,173 after triple dye application. Cords treated
since no data on sepsis are included. The search
with bacitracin had significantly higher
strategy should be better described and
colonization rates when compared to triple dye
observational studies (case control and cohort
prophylaxis. Bacterial colonization with
studies) from poor countries should be included
Staphylococcus epidermidis and group B beta-
since there are no randomized control trials from
hemolytic streptococcus was found only after
these countries.
bacitracin prophylaxis. Our data support the use of
triple dye for routine cord care and suggest that
bacitracin application may increase the rate of Bennett, J., C. Ma, H. Traverso, S. B. Agha, and J.
group B streptococcal colonization. Boring. 1999. “Neonatal tetanus associated
with topical umbilical ghee: covert role of cow
dung,” Int. J. Epidemiol., vol. 28, no. 6,
Arad, I., F. Eyal, and P. Fainmesser. 1981.
pp. 1172–1175.
“Umbilical care and cord separation,” Arch.
Dis. Child, vol. 56, no. 11, pp. 887–888. Abstract: BACKGROUND: Previous studies in
Pakistan have shown that ghee (clarified butter) is
Abstract: Four different treatments for the care of
commonly applied to umbilical wounds of
the umbilical cord were compared in a randomized,
neonates, and have documented that such
controlled study. Triple dye was associated with a
applications are a risk factor for neonatal tetanus
significantly earlier separation of the cord than
(NNT). In-use contamination of ghee with
either 1% neomycin or 1% silver sulphadiazine
Clostridium tetani has been demonstrated, but
ointment, and it was nearly as effective as bismuth
mechanisms underlying the risk of ghee have been
subgallate (an astringent powder) in causing rapid
incompletely evaluated epidemiologically.
sloughing. If the mother is made aware that care of
METHODS: Detailed information on ghee usage,
the umbilical cord may delay cord separation she
including fuels used to heat it, was obtained from
may be spared unnecessary concern.
cases of NNT (n=229) and their matched controls
(n=687) from a population-based study of NNT in
Axelsson, I. 2002. “A Cochrane review on the Punjab Province, Pakistan. Design variables were
umbilical cord care and prevention of created to evaluate the impact of different fuel
infections. Antiseptic solutions are not necessary sources on risk of ghee applications. RESULTS:
in developed countries but life-saving in Nearly one-third of all infants had ghee applied,
developing countries,” Lakartidningen, vol. 99, and it was nearly always heated before application
no. 14, pp. 1563–1566. to umbilical wounds of newborns. After controlling
for all factors found to be significantly associated
Abstract: One million newborn infants die every with NNT in conditional logistic regression, only
year by bacterial infections, which often have ghee that had always been heated with dried cow
entered the body via the umbilicus. A Cochrane dung fuel was significantly associated with NNT.
systematic review on “Topical umbilical cord care Topical antimicrobials and ghee were never applied
CORD CARE
145
microbial contamination. In contrast, ghee heated effective than the current treatment employed. One
with dung fuel was significantly associated with hundred and three babies were included in the
NNT. The effective promotion of topical study. The cords of babies nursed in one postnatal
antimicrobials might help reduce ghee use, since ward were not treated (trial group); babies nursed
the intended purpose of each is to enhance healing. in another postnatal ward became the control
group whose cords were treated with spirit (alcohol
70%) and ties. Cords separated earlier for the trial
Bennett, J., J. Macia, H. Traverso, S. Banoagha, C. group (mean 6.4 days) than the control group
Malooly, and J. Boring. 1997. “Protective (mean 8.04 days) and mothers of trial group babies
effects of topical antimicrobials against neonatal reported fewer problems with umbilical cords than
tetanus,” Int. J. Epidemiol., vol. 26, no. 4, those of control group babies.
pp. 897–903.
Abstract: BACKGROUND: Case-control studies
Garner, P., D. Lai, M. Baea, K. Edwards, and P.
previously conducted in Pakistan suggested that
Heywood. 1994. “Avoiding neonatal death: an
topical antimicrobials might provide protection
intervention study of umbilical cord care,” J.
against neonatal tetanus (NNT) when applied to
Trop. Pediatr., vol. 40, no. 1, pp. 24–28.
the umbilical cord wound during the first several
days of life. The present case-control study, the Abstract: During a study of pregnancy in a poor
largest such study yet reported, was undertaken in rural tropical area, a high prevalence of neonatal
Punjab Province, Pakistan and afforded further fever and umbilical cord infection was detected.
opportunities to evaluate such effects. METHODS: Interim analysis showed that this was associated
A population-based, matched, case-control study with subsequent development of neonatal sepsis.
was undertaken to assess topical antimicrobials Therefore an intervention was introduced in two
and other factors related to NNT risk in rural parts stages. In the first stage, acriflavine spirit and new
of Punjab Province. RESULTS: Continuous use of razor blades were supplied to mothers, along with
antimicrobial agents (antibiotics and antiseptics) at instructions for use, through antenatal clinics. In
delivery and during the first few days after delivery the second stage, when excessive cord bleeding was
was highly protective in univariate testing (matched reported, umbilical cord clamps were added to the
odds ratio 0.2 [95% confidence interval: pack. The packs were associated with reduction of
0.11–0.64], P=0.003), and remained significantly serious morbidity in the neonatal period. The study
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
protective when other delivery and cord care demonstrates the importance of umbilical cord care
practices were controlled. In contrast, applying in the etiology of life threatening neonatal
nothing to the wound was risky compared with morbidity in village births in a developing country
antimicrobial exposures. Hand washing and and the effect of a simple intervention in reducing
delivery by a trained birth attendant appeared morbid episodes in the neonate.
protective. Application of animal dung or ash to
the umbilical wound was hazardous. Similarly,
predelivery cutaneous or intravaginal exposure of Golombek, S. G., P. E. Brill, and A. L. Salice. 2002.
mothers to ghee (clarified butter) and delivery on a “Randomized trial of alcohol versus triple dye
surface prepared with dried cow dung were risky, for umbilical cord care,” Clin. Pediatr. (Phila.),
with significant interaction noted between them. vol. 41, no. 6, pp. 419–423.
Mortality and NNT were far more likely among Abstract: Over a four-month period, all infants
previous births to mothers of cases. admitted to the well-baby nursery were enrolled in
CONCLUSIONS: Topical antimicrobials offer a a prospective study designed to compare cord
new, effective and inexpensive means to prevent separation times between infants treated with triple
NNT, and could usefully complement maternal dye once, followed by daily alcohol application, to
immunization with tetanus toxoid in controlling infants treated with daily alcohol application alone.
the disease. Special prevention efforts should be Follow-up phone calls were done seven days after
directed towards mothers of NNT cases. discharge, with weekly calls until cord separation
occurred. The objective was to determine whether
the umbilical cord care regimen of triple dye
Bourke, E. 1990. “Cord care: too much or too
followed by alcohol has an advantage over the
little,” Aust. J. Adv. Nurs., vol. 7, no. 2,
alternative regimen of alcohol alone, with regard to
pp. 19–22.
cord separation, parenting, or healthcare caretaker
Abstract: This research project was undertaken at a preferences. In total, 634 infants were enrolled,
teaching hospital to determine whether no with 599 infants (94%) completing the study.
treatment of newborns’ umbilical cords was more Infants in the alcohol alone group had a shorter
146
cord separation time by three days (10 days versus umbilical cord after birth has recently been
13 days) (p<0.0001). There was no reported abandoned by many neonatal units in favor of dry
increase in infection, and monetary savings were cord care. The objective of this study was to
noted. We conclude that alcohol applied once a day compare cord bacterial colonization and morbidity
appears to be a safe and effective means of among newborns whose cords were treated with
promoting cord detachment. triple dye and alcohol versus dry cord care.
METHODOLOGY: We randomly allocated
766 newborns to either two applications of triple
Guala, A., G. Pastore, V. Garipoli, M. Agosti, M. dye to the umbilical cord stump on the day of birth
Vitali, and G. Bona. 2003. “The time of with alcohol swabbing twice daily until the cord
umbilical cord separation in healthy full-term fell off (n=384) or dry care (n=382). Dry care
newborns: a controlled clinical trial of different consisted of spot cleaning soiled skin in the
cord care practices,” Eur. J. Pediatr., vol. 162, periumbilical area with soap and water, wiping it
no. 5, pp. 350–351. with a dry cotton swab or cloth, and allowing the
Abstract: Research letter available at: area to air dry. Umbilical stumps on all subjects
http://www.springerlink.com/app/home/content.asp were swabbed and cultured. Community health
?wasp=12d237n82c4ywm4c750xandreferrer=contr nurses visiting at two or three days after hospital
ibutionandformat=2andpage=1 discharge observed the stump for signs of infection.
Follow-up phone calls were made to mothers
within three weeks of discharge. RESULTS: One
Hsu, C. F., C. C. Wang, Y. S. Yuh, Y. H. Chen, and infant in the dry care group was diagnosed with
M. L. Chu. 1999. “The effectiveness of single omphalitis. The umbilical stump was colonized
and multiple applications of triple dye on with alpha-hemolytic streptococcus and coagulase-
umbilical cord separation time,” Eur. J. Pediatr., negative staphylococcus. Infants in the dry care
vol. 158, no. 2, pp. 144–146. group were significantly more likely to be
Abstract: The effectiveness of single and multiple colonized with Escherichia coli (34.2% vs. 22.1%),
applications of triple dye for umbilical cord care in coagulase-negative staphylococci (69.5% vs.
the umbilical cord separation time (UCST) was 50.5%), Staphylococcus aureus (31.3% vs. 2.8%),
evaluated in 180 neonates. Seven neonates were and group B streptococci (11.7% vs. 6.0%).
excluded, three where the cord stump separation Community health nurses were significantly more
time was uncertain and four to whom contact was likely to observe exudate (7.4% vs. 0.3%) and foul
lost. The participating neonates were randomly odor (2.9% vs. 0.7%) among infants allocated to
assigned to two groups. Group 1, 101 neonates, the dry care group during the home visit.
was treated with a regimen of a single application CONCLUSIONS: Omphalitis remains a clinical
of triple dye. Group 2, 79 neonates, was treated issue. Cessation of bacteriocidal care of the
with multiple applications of triple dye. Complete umbilical stump must be accompanied by vigilant
information was obtained from 97 neonates attention to the signs and symptoms of omphalitis.
(96.2%) in group 1 and 76 (96%) in group 2. The
UCST was 12.6 +/– 0.45 (mean +/– SE) days in Jeng, M. J., W. J. Soong, M. C. Lau, S. J. Chen,
group 1 and 16.68 +/– 0.65 days in group 2 and B. Hwang. 1994. “The efficacy of different
(P<0.0001) and showed no significant association umbilical cord care regimens: an in vitro study
with infants’ gender, mode of delivery, gravidity, on their drying and antimicrobial effect,”
gestational age, birthweight, or hospital stay. Zhonghua Yi. Xue. Za Zhi. (Taipei), vol. 53,
CONCLUSION: A single application of triple dye no. 5, pp. 293–297.
may be a more favorable regimen with a similarly
antimicrobial effect, a shorter UCST and may be Abstract: BACKGROUND: Topical regimens have
more cost effective than multiple applications of been used for umbilical cord care for different
triple dye in umbilical cord care. purposes, but their drying efficacy has rarely been
statistically analyzed. We designed an in vitro study
with six regimens to determine which one can
Janssen, P. A., B. L. Selwood, S. R. Dobson, D. achieve the best drying and antimicrobial effects in
Peacock, and P. N. Thiessen. 2003. “To dye or umbilical cord care. METHODS: Twenty-seven
CORD CARE
not to dye: a randomized, clinical trial of a umbilical cords were resected when babies were
triple dye/alcohol regime versus dry cord care,” born. Each cord was cut into seven segments in
Pediatr., vol. 111, no. 1, pp. 15–20. appropriate length and randomly labeled to seven
Abstract: OBJECTIVE: The use of antibacterial groups. Six regimens including 75% alcohol, 90%
agents to clean and dry the stump of the newborn’s alcohol, tincture povidone-iodine, aqua povidone-
147
iodine, Chinese herbs, and one powder agent (M) Abstract: The time of cord separation and the
were used topically on six groups of umbilical umbilical changes post cord falling were studied in
cords once daily. The control group received no 394 infants, 35 to 42 weeks’ gestation, 1,900g to
treatment. Daily weight of the cords was recorded 4,500g birthweight. Two methods of treatment—
for seven days, and bacterial culture was performed alcohol 70% with 0.5% chlorhexidine, and
on the sixth day. RESULTS: All study groups Rikospray—were compared. The mean +/– SD age
presented similar algebraic functional relationship of cord separation was 6.36 +/– 2.64 days (range
between weight change and time. The drying effect 3–20 days) in all infants studied. The time of cord
occurred mostly within the first three days (weight separation and post fall umbilical complications
loss 88.6%), especially on the first day (62.1%). were similar in the two treated groups. The only
Mean ratio of the final weight/initial weight was point of difference was the repulsive odor in the
10.2%. Significant day-by-day weight loss was alcohol-treated group, making handling of the
noted from day 1 to day 5 (p<0.001). Both aqua infants very unpleasant.
and tincture povidone-iodine groups showed not
only satisfied drying effect but also significantly
better antimicrobial effect than other groups. Novack, A. H., B. Mueller, and H. Ochs. 1988.
CONCLUSIONS: Povidone-iodine has both good “Umbilical cord separation in the normal
drying and antimicrobial effects in umbilical cord newborn,” Am. J. Dis. Child, vol. 142, no. 2,
care. As the topical use of povidone-iodine has pp. 220–223.
been reported to relate to transient neonatal Abstract: During a 13-month period, 363 infants
hypothyroidism, we suggest it to be used only as a were followed up through the first six weeks to
good substitute if there are signs of umbilical cord determine the effect of perinatal factors
infection. (birthweight, gestational age, type of delivery, and
pregnancy and neonatal complications) on
umbilical cord separation. Also, breastfeedings and
Mekbib, T. A. and S. Mengistu. 1999. “Rubber
umbilical cord care were studied. Except for
ring clamping of the umbilical cord: a
cesarean section deliveries, study infants were
randomized trial,” Trop. Doct., vol. 29, no. 3,
similar to all infants (N=1,474) admitted to the
pp. 156–159.
same nursery during the study period. Cord
Abstract: A randomized trial to compare two separation occurred from days 3 to 45, with a
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
methods of umbilical cord tying in neonates, mean of 13.9 days. Infants born by cesarean
immediately after birth, was undertaken from section were found to have an increased interval
February to April 1997 in the Department of for cord separation when compared with infants
Obstetrics and Gynaecology, Zewditu Memorial born vaginally (mean +/– SD, 15.9 +/– 5.0 days vs.
Hospital, Addis Ababa, Ethiopia. In less than three 12.9 +/– 4.2 days). In this study, delays in
months, we investigated 300 neonates, of whom separation of the umbilical cord beyond three
150 infants were randomly assigned to the weeks of age was not associated with an increased
traditional ligation of the umbilical cord (using a risk of infection.
piece of thread) and the rest to a rubber ring
clamping method. Among the former group,
13.3% (20/150) of the neonates bled from their Obimbo, E., R. N. Musoke, and F. Were. 1999.
umbilical cords which necessitated re-tying, “Knowledge, attitudes and practices of mothers
whereas in the later group, there was no sign of and knowledge of health workers regarding
hemorrhage or infection within 12 hours of care of the newborn umbilical cord,” East Afr.
clamping. We suggest that the rubber ring method Med. J., vol. 76, no. 8, pp. 425–429.
described is a superior procedure and can easily Abstract: OBJECTIVE: To determine the
replace the traditional, cumbersome and time- knowledge, attitudes and practices (KAP) of
consuming umbilical cord ligation. mothers and the knowledge of health workers
regarding care of the newborn umbilical cord.
DESIGN: Cross-sectional survey. SUBJECTS:
Naor, N., P. Merlob, A. Litwin, and E. Wielunksy.
Mothers with infants less than three months of age
1989. “Time of separation of the umbilical cord:
attending well child clinics and health workers
a comparative study of treatment with alcohol
(HW) in the clinics, maternity and newborn units
and Rikospray,” Eur. J. Obstet. Gynecol.
of public health, facilities serving an urban slum
Reprod. Biol., vol. 32, no. 2, pp. 89–93.
area in Nairobi, Kenya. RESULTS: Of the
148
307 mothers interviewed, 91% and 28% of carefully collected data on bacterial colonization,
mothers knew of the need for hygiene whilst they were quickly aware of the problem and could
cutting and tying the cord, respectively. Regarding justify resuming the use of triple dye.
postnatal cord care, 40% had good knowledge and
66% good practice. Fifty-one percent of mothers
knew and 54% practiced postnatal cord care for Parashar, U. D., J. V. Bennett, J. R. Boring, and W.
the appropriate duration of time. Seventy-nine G. Hlady. 1998. “Topical antimicrobials
percent of mothers were afraid of handling an applied to the umbilical cord stump: a new
unhealed cord. After multivariate analysis, the intervention against neonatal tetanus,” Int. J.
following variables showed significant independent Epidemiol., vol. 27, no. 5, pp. 904–908.
association with good maternal KAP; increased Abstract: BACKGROUND: Previous case-control
level of education (OR=2.3, p<0.001), living in studies of neonatal tetanus (NNT), a leading cause
middle class areas rather than slums (OR=1.5, of infant mortality in developing countries, have
p<0.03), increased maternal age (OR=1.8, suggested that antimicrobials applied after delivery
p<0.001), acquisition of knowledge from a HW to the umbilical cord stump may protect against
rather than from other sources (OR=1.5, p<0.001), this disease. However, assessment of their
and living in stone/brick houses rather than mud protective effect has been limited by the low
houses (p=0.01). Fifty percent of HW had correct prevalence of antimicrobial use in developing
knowledge on type of postnatal cord care, and countries. METHODS: We conducted a
79% had correct knowledge on duration required population-based, matched, case-control study to
for the same. The knowledge of 50% on type of assess the use of antimicrobials and other factors
care was incorrect by international standards, but potentially related to NNT in rural parts of
was in keeping with Nursing Council of Kenya Bangladesh. We studied 359 cases (infants who
teaching. CONCLUSION: Mothers had good were normal at birth but who died between the
knowledge on the need for hygiene when cutting third and thirteeth day of life after an illness
the cord, had poor knowledge and practice in other characterized by signs of NNT), each matched to
aspects of cord care, and were afraid of handling three living controls for gender, residence, and date
the cord. Poor KAP was associated with young, of birth. RESULTS: In univariate analyses, the
poor mothers of low education, who had acquired application of either antibiotics or disinfectants at
their knowledge from sources other than HW. The delivery, and the continuous or any application of
knowledge of a large proportion of HW was disinfectants were protective against NNT. The
incorrect and outdated. We recommend that health application of antibiotics at delivery (odds ratio
education on cord care be given at all levels of [OR]=0.21, P=0.019), hand washing by the
contact with mothers and that knowledge of all delivery attendant (OR=0.64, P=0.005), and prior
primary HW on cord care be updated. maternal immunization with tetanus toxoid
(OR=0.50, P<0.001) remained protective in
conditional logistic-regression analyses. Application
Paes, B. and C. C. Jones. 1987. “An audit of the
of animal dung to the umbilical stump (OR=2.31,
effect of two cord-care regimens on bacterial
P=0.047) was hazardous. CONCLUSIONS:
colonization in newborn infants,” Q.R.B. Qual.
Effective and inexpensive topical antimicrobials
Rev. Bull., vol. 13, no. 3, pp. 109–113.
provide a new prevention opportunity that could
Abstract: Proper care of the umbilical cord of be used by traditional birth attendants and mothers
newborn infants may prevent later infections. to provide additional benefits to NNT control
When St Joseph’s Hospital in Hamilton, Ontario, programs based on maternal immunization with
started using alcohol instead of triple dye for tetanus toxoid. Promotion of hygienic delivery and
umbilical cord care, there was a dramatic increase cord-care practices and increasing tetanus toxoid
in the incidence of bacterial colonization in coverage remain cornerstones for the prevention of
newborns in the nursery and, later, in the number NNT deaths.
of cases of staphylococcus-related skin infections in
infants born at the hospital. Follow-up on
1,545 infants revealed that triple dye was Pezzati, M., E. C. Biagioli, E. Martelli, B. Gambi,
significantly more effective than alcohol in R. Biagiotti, and F. F. Rubaltelli. 2002.
CORD CARE
reducing the growth of Gram-positive organisms, “Umbilical cord care: the effect of eight
especially Staphylococcus aureus and group B different cord-care regimens on cord separation
streptococcus, and several Gram-negative time and other outcomes,” Biol. Neonate,
organisms. Because hospital medical staff had vol. 81, no. 1, pp. 38–44.
149
Abstract: In this study we evaluate the effect of Abstract: The incidence and types of
eight cord-care regimens on cord separation time staphylococcal purulent lesions were prospectively
and other secondary outcomes: omphalitis, sepsis, studied among 3,602 newborn infants. During an
death, cord bleeding, compliance, satisfaction or epidemic of post-discharge pyoderma, 87% of all
dissatisfaction with regard to the type of treatment, Staphylococcus aureus isolates from lesions could
umbilical cord colonization—in 1,535 healthy term be traced to the nursery. The risk of post-discharge
infants. The eight cord-care regimens studied were: disease was related to the degree of staphylococcal
70% alcohol, natural drying, salicylic sugar skin colonization in the nursery. A method for
powder, triple dye, micronized green clay powder, routine cord care in the nursery with 4%
colloid silver-benzyl-peroxide powder, neomycin- chlorhexidine-detergent solution was evaluated and
bacitracin powder, 1% basic fuchsine. None of the proved to be effective in reducing staphylococcal
newborns developed sepsis or died and we found colonization in the nursery as well as purulent skin
only sporadic cases of omphalitis. With regard to disease at home. The clinical effectiveness of the
cord separation time the best results were obtained regimen was followed up for 19 months and a
with salicylic sugar powder (5.6 +/– 2.3 days) and persistent low infection rate was obtained among
green clay powder (6.7 +/– 2.2 days). Both forms infants in the post-discharge period.
of treatment proved to be more effective (p<0.05)
than all the others. We found that salicylic sugar
powder allows for early cord detachment resulting Smales, O. 1988. “A comparison of umbilical cord
in excellent parent treatment compliance and treatment in the control of superficial
reduction of their concern, notwithstanding higher infection,” N. Z. Med. J., vol. 101, no. 849,
percentages of cord bleeding. The rate of positive pp. 453–455.
umbilical swabs was low and was significantly Abstract: Owing to a high incidence of superficial
higher only than the results obtained with infection in the newborn period the existing cord
neomycin-bacitracin powder treatment. This study care treatment of Iodosan 10% in surgical spirit
demonstrates that, in hospital nurseries of was compared with 4% chlorhexidine detergent
developed countries, salicylic sugar powder can be solution. A prospective crossover study was
effectively and safely used for umbilical cord care performed between two comparable maternity
of healthy term infants. units. Cord bacteriology was assessed at the time
of discharge from hospital and the day of cord
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
150
Abstract: A randomized controlled study was 104 compared with 41 (42%) of 98 controls.
undertaken to compare the effectiveness of three Chlorhexidene was associated with cord
umbilical cord treatment regimens in controlling attachment at 10 days in 29 (28%) infants
neonatal bacterial colonization. The regimens compared with 31 of 515 (6%) infants when it
studied included daily application of castile soap, was not used. Hexachlorophane was more
triple dye and silver sulfadiazine. The triple dye acceptable to the nursing staff. The reduction in
and silver sulfadiazine regimens inhibited bacterial colonization with the two compounds was largely
colonization. Staphylococcal colonization was due to the suppression of cross infection.
inhibited most effectively by triple dye treatment.
Group B streptococcal colonization was equally
inhibited by triple dye and silver sulfadiazine. Silver Wald, E. R., M. J. Snyder, and R. L. Gutberlet.
sulfadiazine was more effective in controlling 1977. “Group B beta-hemolytic streptococcal
colonization with Gram-negative microorganisms. colonization. Acquisition, persistence, and effect
of umbilical cord treatment with triple dye,”
Am. J. Dis. Child, vol. 131, no. 2, pp. 178–180.
Speck, W. T., J. M. Driscoll, R. A. Polin, J. O’Neill,
Abstract: Following an outbreak of group B beta-
and H. S. Rosenkranz. 1977. “Staphylococcal
hemolytic streptococcal neonatal infection (GBS), a
and streptococcal colonization of the newborn
prevalence survey of GBS colonization was
infant: effect of antiseptic cord care,” Am. J.
performed on 238 infants. No important
Dis. Child, vol. 131, no. 9, pp. 1005–1008.
differences were noted in the prevalence of
Abstract: A randomized controlled study was colonization when the infants were grouped
undertaken to compare the effectiveness of three according to age. Follow-up of 24 colonized babies
umbilical cord treatment regimens in controlling for three months disclosed that most had
neonatal bacterial colonization. The three persistence of GBS at the rectum and pharynx.
regimens studied included castile soap, triple dye, Local umbilical cord care with triple dye (TD) or
and silver sulfadiazine. The triple dye and silver hexachlorophene skin cleanser was compared with
sulfadiazine application inhibited bacterial untreated controls with respect to rates of GBS
colonization. Staphylococcal colonization was colonization. At birth the colonization rates of the
inhibited by both treatment regimens but most three groups were similar. The rate of acquisition
effectively by triple dye. Group B streptococcal of colonization with GBS was 1.0% in the TD
colonization was inhibited most effectively by group, 6.3% in the hexachlorophene group, and
silver sulfadiazine while triple dye application to 8.3% in the control group. Triple dye was much
the umbilicus promoted colonization with this more effective than no specific cord care or
microorganism. Silver sulfadiazine was more hexachlorophene in preventing acquisition of GBS
effective in controlling colonization with Gram- colonization.
negative microorganisms.
Watkinson, M. and A. Dyas. 1992.
Verber, I. G. and F. S. Pagan. 1993. “What cord “Staphylococcus aureus still colonizes the
care—if any?” Arch. Dis. Child, vol. 68, no. 5 untreated neonatal umbilicus,” J. Hosp. Infect.,
Spec No, pp. 594–596. vol. 21, no. 2, pp. 131–136.
Abstract: The use of antiseptic treatment during Abstract: Two different neonatal umbilical cord
cord care varies from unit to unit. Although it may treatment regimens were studied prospectively.
reduce bacterial colonization it may also delay Although a greater proportion of cords had
cord separation. Where antiseptic treatment is separated by the seventh day in those babies not
used there is uncertainty as to the best agent. treated with topical antiseptics (47% vs. 26%),
Hexachlorophane powder (0.3%) and 4% there was a significant excess (53% vs. 30%) of
chlorhexidene detergent were each compared with umbilical colonization by Staphylococcus aureus
dry cord care as a control on a two-ward compared to those neonates whose cords were
maternity unit in a six-month open study. Of 133 treated with alcohol wipes and hexachlorophane
infants treated with hexachlorophane, 44 (33%) powder. The main purpose of treating cords is to
CORD CARE
became heavily colonized with Staphylococcus prevent significant S. aureus colonization, and
aureus compared with 80 (47%) of 171 controls— therefore current proposals to stop antiseptic
a reduction of one-third. Chlorhexidene reduced treatment of umbilical cords should be
colonization by more than half; 17 (16%) of disregarded.
151
Wong, P., E. O. Mason, Jr., and F. F. Barrett. 1977. Zupan, J. and P. Garner. 2000. “Topical umbilical
“Group B streptococcal colonization in a cord care at birth,” Cochrane. Database. Syst.
newborn nursery: effects of iodophor and triple Rev., no. 2, p. CD001057.
dye cord care,” South. Med. J., vol. 70, no. 8,
Abstract: BACKGROUND: Umbilical cord
pp. 978–979.
infection caused many neonatal deaths before
Abstract: Control of nosocomial group B aseptic techniques were used. OBJECTIVES: The
streptococcal (GBS) colonization of newborn objective of this review was to assess the effects of
infants was attempted in a four-cycle study topical cord care in preventing cord infection,
alternately employing single applications of illness and death. SEARCH STRATEGY: We
povidone-iodine (iodophor) and triple dye to the searched the Cochrane Pregnancy and Childbirth
umbilical cord stump and periumbilical area. GBS Group trials register, the Cochrane Controlled
colonization rates were 49% and 34% following Trials Register (Cochrane Library issue 4, 1997)
iodophor cord care (cycles II and III) and 11% and and Medline. We also contacted experts in the
50% following triple dye cord care (cycles II and field. SELECTION CRITERIA: randomized and
IV). The apparent significant reduction of GBS quasi-randomized trials of topical cord care
colonization during triple dye cycle II could not be compared with no routine care, and comparisons
reproduced in a subsequent follow-up culture between different forms of care. DATA
survey and remains unexplained. COLLECTION AND ANALYSIS: Two reviewers
assessed trial quality and extracted data. MAIN
RESULTS: Ten studies were included, all from
World Health Organization. 1998. Care of the developed countries. No systemic infections or
umbilical cord: a review of the evidence. deaths were observed in any of the studies
Abstract: This document reviews the available reviewed. Cord and other skin infections within six
evidence on cord care of the newborn and attempts weeks of observation were not affected by use of
to provide policy-makers, managers of health antiseptics. There was a trend to reduced
facilities and senior health professionals with colonization with antibiotics compared to
recommendations on clean cord care based on the antiseptics and no treatment. Antiseptics prolonged
evidence. the time to cord separation. Use of antiseptics was
associated with a reduction in maternal concern
Available at: about the cord. REVIEWER’S CONCLUSIONS:
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
152
Eye Care
Bernstein, G. A., J. P. Davis, and M. L. Katcher. Hammerschlag, M. R., C. Cummings, P. M.
1982. “Prophylaxis of neonatal conjunctivitis. Roblin, T. H. Williams, and I. Delke. 1989.
An analytic review,” Clin. Pediatr. (Phila.), “Efficacy of neonatal ocular prophylaxis for the
vol. 21, no. 9, pp. 545–550. prevention of chlamydial and gonococcal
conjunctivitis,” N. Engl. J. Med., vol. 320,
Abstract: The recommendation by the Centers for
no. 12, pp. 769–772.
Disease Control (CDC) that erythromycin and
tetracycline ointments, as well as silver nitrate Abstract: Opinions differ concerning the efficacy of
solution, are acceptable regimens for prophylaxis prophylaxis against neonatal chlamydial and
of gonococcal ophthalmia neonatorum (GON) has gonococcal conjunctivitis. From January 1986
resulted in widespread local review of policies for through June 1988, we gave all infants born at
ocular prophylaxis. The data concerning the Kings County Hospital Medical Center one of
efficacy and side effects of these agents are three prophylactic agents—silver nitrate drops,
somewhat confusing or nonexistent. We discuss the erythromycin ophthalmic ointment, or tetracycline
etiologies of neonatal conjunctivitis and the topical ophthalmic ointment. The treatments were rotated
and systemic agents used for prophylaxis of GON. monthly. Gonococcal ophthalmia occurred in eight
We also review all studies that have compared the of the 12,431 infants born during the study
efficacy of one prophylactic agent with that of (0.06%), one in the silver nitrate group, four in the
another agent or with no prophylaxis. It is found erythromycin group, and three in the tetracycline
that all three agents have similar efficacy in group (P not significant). Seven of these infants
preventing GON, although silver nitrate has been were born to women who had received no prenatal
used more extensively in populations at high risk care. From September 1985 through December
for GON. However, since Chlamydia trachomatis 1987, we screened 4,357 pregnant women for
is the most common infectious cause of neonatal cervical chlamydial infection, of whom
conjunctivitis in the United States at this time, and 341 (8%) had positive cultures. Of their offspring,
erythromycin appears to be very effective in 230 were evaluated for neonatal chlamydial
prevention of neonatal conjunctivitis due to C. conjunctivitis; the incidence was 20% in the silver
trachomatis, it may have an advantage over the nitrate group, 14% in the erythromycin group, and
other two agents. In addition, erythromycin use is 11% in the tetracycline group (P not significant).
associated with fewer ocular reactions than is silver We conclude that neonatal ocular prophylaxis with
nitrate. either erythromycin or tetracycline ophthalmic
ointment does not significantly reduce the
incidence of chlamydial conjunctivitis in the
Crede, C. 2001. “Prevention of Inflammatory Eye offspring of mothers with chlamydial infection as
Disease in the Newborn,” Bull. World Health compared with silver nitrate, and that better
Organ., vol. 79, no. 3, pp. 264–266. management of maternal chlamydial infection is
Abstract: I am not publishing the following therefore required. We also conclude that there is a
information concerning the prevention of small but appreciable incidence of neonatal
inflammatory eye disease in the newborn in a gonococcal ophthalmia that could be prevented by
specialist journal on ophthalmology but in this better prenatal screening and treatment of maternal
Archive because the disease is almost invariably gonococcal infection.
caused by infection during delivery and is therefore
directly related to a diseased condition of the
Hammerschlag, M. R., J. W. Chandler, E. R.
female genitals. Responsibility for prevention of the
Alexander, M. English, W. T. Chiang, L.
disease must also lie solely with obstetricians and
Koutsky, D. A. Eschenbach, and J. R. Smith.
midwives. I shall confine my remarks exclusively to
1980. “Erythromycin ointment for ocular
the practical question of prophylaxis.
prophylaxis of neonatal chlamydial infection,”
Available at: JAMA, vol. 244, no. 20, pp. 2291–2293.
EYE CARE
http://www.who.int/bulletin/tableofcontents/2001/v
Abstract: We compared the efficacy of
ol.79no.3.html
erythromycin ophthalmic ointment vs. 1% silver
153
nitrate drops for the prevention of neonatal (13.9%, P<0.001) and 148 in the erythromycin
conjunctivitis or respiratory tract infection from group (13.3%, P=0.004). Many cases of
Chlamydia trachomatis. The organism was isolated noninfectious conjunctivitis were probably due to a
from the cervix of 67 (12%) of 572 pregnant toxic reaction to the treatment itself. The incidence
women. They gave birth to 559 infants who were of Neisseria gonorrheae and Staphylococcus aureus
randomly assigned to either prophylaxis infections was similar in the three groups.
immediately after birth. Thirty-six of 60 infants CONCLUSIONS: A 2.5% ophthalmic solution of
born to Chlamydia-positive women received silver povidone-iodine as prophylaxis against ophthalmia
nitrate; 24 received erythromycin. Twelve (33%) of neonatorum is more effective than treatment with
the 36 infants who received silver nitrate had silver nitrate or erythromycin, and it is less toxic
chlamydial conjunctivitis, but none of the and costs less.
24 infants who received erythromycin did. Ten
(29%) of 36 infants receiving silver nitrate had
chlamydial nasopharyngeal infection (three later Laga, M., F. A. Plummer, P. Piot, P. Datta, W.
had pneumonia), as opposed to five (21%) of 24 Namaara, J. O. Ndinya-Achola, H. Nzanze, G.
who received erythromycin (one had pneumonia). Maitha, A. R. Ronald, H. O. Pamba. 1988.
Thus, erythromycin ointment is effective in “Prophylaxis of gonococcal and chlamydial
prevention of chlamydial conjunctivitis, but it may ophthalmia neonatorum. A comparison of silver
not reduce nasopharyngeal infection or subsequent nitrate and tetracycline,” N. Engl. J. Med.,
pneumonia. vol. 318, no. 11, pp. 653–657.
Abstract: We evaluated the use of silver nitrate
drops and tetracycline ointment for the prophylaxis
Isenberg, S. J., L. Apt, and M. Wood. 1995. “A
of ophthalmia neonatorum in a controlled trial
controlled trial of povidone-iodine as
involving 2,732 newborns in Nairobi, Kenya. The
prophylaxis against ophthalmia neonatorum,”
overall rates of prevalence of intrapartum maternal
N. Engl. J. Med., vol. 332, no. 9, pp. 562–566.
gonococcal and chlamydial infection were
Abstract: BACKGROUND: Neonatal conjunctivitis 6.4% and 8.9%, respectively. After prophylaxis
(ophthalmia neonatorum) continues to cause with silver nitrate, the incidence rates of
blindness because the agents used prophylactically gonococcal, chlamydial, and nongonococcal,
to prevent this condition are not completely nonchlamydial ophthalmia neonatorum were
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
effective and are not widely available in many parts 0.4%, 0.7%, and 6.2%, respectively, whereas after
of the world. Povidone-iodine ophthalmic solution prophylaxis with tetracycline, the rates were
is an effective antibacterial agent with broad 0.1%, 0.5%, and 4.5%. The attack rates of
antibacterial and antiviral activity to which no gonococcal ophthalmia neonatorum in newborns
bacteria are known to be resistant, and it is far less exposed to Neisseria gonorrheae at birth were
expensive and less toxic than the agents currently 7.0% in those receiving silver nitrate and 3.0% in
used to prevent neonatal conjunctivitis. those receiving tetracycline (95% confidence
METHODS: We conducted a masked, prospective interval for the difference in rates, –3.4% to
trial involving 3,117 infants born over a period of 11.4%). As compared with historical controls, the
30 months in a hospital in Kenya. Shortly after incidence of gonococcal ophthalmia neonatorum
birth each infant received a 2.5% solution of decreased 83% among infants treated with silver
povidone-iodine (n=1,076), a 1% solution of silver nitrate and 93% among those treated with
nitrate (n=929), or 0.5% erythromycin ointment tetracycline. Failure of prophylaxis was associated
(n=1,112) in both eyes. Randomization was with postpartum maternal endometritis (P=0.05).
achieved by rotating the three medications after Among newborns exposed to maternal infection
each was used for a week. RESULTS: Of the with Chlamydia trachomatis, chlamydial
neonates treated with povidone-iodine, 13.1% had conjunctivitis developed in 10.1% given silver
infectious conjunctivitis, as compared with 17.5% nitrate and in 7.2% given tetracycline (95%
of those treated with silver nitrate (P<0.001) and confidence interval for the difference in rates,
15.2% of those treated with erythromycin –4.7 to 10.5%), yielding reductions in the
(P=0.01). Povidone-iodine was more effective incidence of chlamydial ophthalmia of 68% and
against Chlamydia trachomatis than was silver 77%, respectively, as compared with the historical
nitrate (P<0.001) or erythromycin (P=0.008). There controls. We conclude that tetracycline is as
were 104 cases of noninfectious conjunctivitis effective as silver nitrate in preventing gonococcal
(9.7%) in the povidone-iodine group, as compared ophthalmia neonatorum.
with 129 in the silver nitrate group
154
Lum, B., R. L. Batzel, and E. Barnett. 1980. and Staphylococcus aureus in a concentration of
“Reappraising newborn eye care,” Am. J. Nurs., 0.1% and against Escherichia coli in a
vol. 80, no. 9, pp. 1602–1603. concentration of 0.01%.
Abstract: Based on our literature investigation, we
recommend the following: Schaller, U. and V. Klauss. 2001. “Is Crede’s
1. Administer silver nitrate 1% ophthalmic prophylaxis for opthalmia neonatorum still
solution or antibiotic solution to all newborns. valid?” Bull. World Health Organ., vol. 79,
2. Do not rinse out the silver nitrate solution no. 3, pp. 262–266.
because rinsing is ineffective in diminishing
conjunctivitis. Abstract: Crede’s prophylaxis represented a
3. Allow infant and parent to become acquainted tremendous step forward in the prevention of
during the first hour of life unless inflammatory eye disease in newborns in the late
contraindicated. If skin-to-skin or Leboyer 19th century. But his original prophylaxis is mainly
techniques are used, defer eye drops prophylaxis effective against gonococcal ophthalmia whereas
for a short time. chlamydial opthalmia neonatorum (ON) is now
more widespread, and silver nitrate may cause
Nurses need to explore further whether silver chemical conjunctivities. In industrialized countries
nitrate or antibiotic instillation delayed for an hour ON is no longer a public health problem and
after birth still provides adequate protection from different strategies for prevention are available, so
gonorrheal ophthalmia. If an hour delay in some countries have chosen to stop prophylaxis at
prophylaxis is harmless, then nurses have an birth and to opt instead for early treatment. But
obligation to promote change. We must work with growing populations, urbanization and increasing
health care colleagues, consumers, and regulatory promiscuity cause a rising incidence of ON in
agencies to implement care that is physiologically developing countries.
and psychologically sound. Routine prophylaxis with topical antibiotics
carries the risk of resistance, especially in patients
with ON due to gonococcal infection. Povidone-
Nishida, H. and H. M. Risemberg. 1975. “Silver
iodine as a topical anti-infective appears to be an
nitrate ophthalmic solution and chemical
effective and cheap alternative. Further
conjunctivities,” Pediatrics, vol. 56, no. 3,
epidemiological research and monitoring on the
pp. 368–373.
incidence of ON and the prevalence of the various
Abstract: The current status of nursery routines of agents in different parts of the world are needed, so
prophylaxis against ophthalmia neonatorum were that prevention and treatment can be adjusted
surveyed by mail questionnaire to 100 leading accordingly and experience with new options can
maternity hospitals. More than 20% of the be analyzed for wide use.
respondents were not using silver nitrate, mainly
Available at:
because of chemical conjunctivitis. The clinical
http://www.who.int/bulletin/pdf/2001/issue3/vol79.
significance and incidence of chemical
no.3.262-266.pdf
conjunctivitis were studied in 1,000 newborns
whose eyes were handled differently. Rinsing after
instillation of silver nitrate does not reduce the
conjunctival irritation. Although 90% of the
infants had conjunctivitis in the first hours of life,
the majority cleared within 24 hours. Chemical
conjunctivitis did not increase secondary infection,
neither did it mask bacterial infection. Silver nitrate
is effective in vitro against Neisseria gonorrhoeae
EYE CARE
155
Breastfeeding and Use of Human Milk
1992. “The effect of colostrum on infant mortality: 6 months (11% versus 1.8%). CONCLUSIONS:
urban rural differentials,” Health and Current status indicators based on a 24-hour
Population: Perspective and Issues. vol. 15, period may be inadequate and even misleading for
no. 3-4, pp. 94–100. many purposes. We propose that in many studies
an indicator called “exclusive breastfeeding since
Abstract: The study investigates the association
birth” could be added.
between use and knowledge of colostrum on
neonatal and post-neonatal deaths. Data from a
1987 survey, conducted.[in Varanasi,] India, were Adams, C., R. Berger, P. Conning, L. Cruikshank,
used. It has been found that the neonatal and post- and K. Dore. 2001. “Breastfeeding trends at a
neonatal deaths were very low, for females familiar Community Breastfeeding Center: an evaluative
with the importance of colostrum and feeding it. survey,” J. Obstet. Gynecol. Neonatal Nurs.,
Findings also revealed that there was no effect of vol. 30, no. 4, pp. 392–400.
social status on the use and knowledge of
colostrum but at the same time a highly significant Abstract: OBJECTIVE: To evaluate the Community
effect of residence was found on the use and Breastfeeding Center’s (CBC) impact on clients’
knowledge of colostrum. breastfeeding experiences. DESIGN: Retrospective
survey; participants were mailed a questionnaire.
SETTING: A hospital-based drop-in center
Aarts, C., E. Kylberg, A. Hornell, Y. Hofvander, operated jointly by the Wellington-Dufferin-Guelph
M. Gebre-Medhin, and T. Greiner. 2000. “How Health Unit and Headwaters Health Care Center
exclusive is exclusive breastfeeding? A and offering professional breastfeeding support and
comparison of data since birth with current peer interaction. PARTICIPANTS: The
status data,” Int. J. Epidemiol., vol. 29, no. 6, 164 mothers of singleton births, both inpatients
pp. 1041–1046. and community clients, who attended the CBC
during a 10-month period in 1996–1997 and
Abstract: BACKGROUND: There is no accepted
completed a survey. MAIN OUTCOME
and widely used indicator for exclusive
MEASURES: A mailed survey with forced-choice
breastfeeding since birth. Indeed, the difference
and open-ended questions. RESULTS: Of the
between “current status” data on exclusive
respondents, 90.9% rated their overall CBC
breastfeeding and data on “exclusive breastfeeding
experience as excellent or good. Seventy-three
since birth” is rarely recognized. We used data
percent of respondents breastfed for four months
from a longitudinal study to examine this issue.
or longer. Primiparae and mothers of preterm
METHODS: A descriptive longitudinal, prospective
infants tended to visit the CBC more frequently,
study design was used in which 506 mother-infant
while achieving duration rates similar to other
157
and dry climatic conditions. The ambient breastfeeding and motor development at 13
temperature was 35°C–40°C and the relative months or five years of age. CONCLUSION: Our
humidity 10%–35%, except during the early data suggest that a longer duration of breastfeeding
morning hours. Sixty-three urine samples were benefits cognitive development.
collected from 31 infants below 6 months of age
and 28 samples from 13 infants aged 6–10 months,
all of whom were receiving nothing but breastmilk. Ashraf, R. N., F. Jalil, S. Zaman, J. Karlberg, S. R.
Specific gravity (and corresponding osmolality) of Khan, B. S. Lindblad, and L. A. Hanson. 1991.
urine samples from the younger group ranged from “Breast feeding and protection against neonatal
1.004 (66 mosmol/liter) to 1.036 (1,234 sepsis in a high risk population,” Arch. Dis.
mosmol/liter), with a mean of Child, vol. 66, no. 4, pp. 488–490.
1.011 (322 mosmol/liter). For the older group the Abstract: Protection against neonatal sepsis by
range was 1.005 (103 mosmol/liter) to 1.029 breastfeeding was investigated in a developing
(978 mosmol/liter) and the mean was 1.015 community. A case-control study was carried out
(468 mosmol/liter). These values are well below with 42 cases from a hospital and 270 controls,
levels of urine concentrations known to be matched for age and socioeconomic conditions
attainable by infants of corresponding ages. Thus, from the community. Exclusive breastfeeding was
even under hotter and drier climatic conditions extremely rare, most babies being partially
than have previously been studied, healthy breastfed and a few being given formula feed or
exclusively breastfed infants do not require animal milk. A highly significant odds ratio of 18
additional water. Exclusive breastfeeding for the was obtained, showing that even partial
first four to six months is therefore a reasonable breastfeeding protects against neonatal sepsis in
public health recommendation; it is imperative in such a population.
areas where contaminated drinking water may
contribute to infant morbidity, diarrheal disease in
particular. Bailey, C. and R. Pain. 2001. “Geographies of
infant feeding and access to primary health-
care,” Health Soc. Care Community, vol. 9,
Angelsen, N. K., T. Vik, G. Jacobsen, and L. S. no. 5, pp. 309–317.
Bakketeig. 2001. “Breast feeding and cognitive
development at age 1 and 5 years,” Arch. Dis. Abstract: Although the benefits of breastfeeding to
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
Child, vol. 85, no. 3, pp. 183–188. mother and infant are now well established, within
Britain initiation rates are low and have changed
Abstract: OBJECTIVE: To examine whether little since 1980. This is despite many health
duration of breastfeeding has any effect on a child’s promotion initiatives aiming to increase
cognitive or motor development in a population breastfeeding. In this paper we discuss some of the
with favorable environmental conditions and a findings of an exploratory qualitative research
high prevalence of breastfeeding. METHODS: In study of infant feeding decisions in Newcastle upon
345 Scandinavian children, data on breastfeeding Tyne, England, where health professionals are
were prospectively recorded during the first year of actively seeking to increase local breastfeeding
life, and neuromotor development was assessed at initiation and duration rates. Our findings suggest
1 and 5 years of age. Main outcome measures were that for health promotion initiatives to be effective
Bayley’s Scales of Infant Development at age 13 across all social groups, there needs to be (i) a
months (Mental Index, MDI; Psychomotor Index, socio-cultural understanding of different social
PDI), Wechsler Preschool and Primary Scales of groups’ access to and interpretation of pre- and
Intelligence (WPPSI-R), and Peabody postnatal formal breastfeeding support health
Developmental Scales at age 5. RESULTS: Children services, and (ii) more appreciation of how
breastfed for less than three months had an mothers’ informal support networks impact on
increased risk, compared to children breastfed for their access to, interpretation and use of formal
at least six months, of a test score below the breastfeeding support.
median value of MDI at 13 months and of WPPSI-
R at five years. Maternal age, maternal intelligence
(Raven score), maternal education, and smoking in Barton, S. J. 2001. “Infant feeding practices of
pregnancy were significant confounders, but the low-income rural mothers,” MCN Am. J.
increased risk of lower MDI and total IQ scores Matern. Child Nurs., vol. 26, no. 2, pp. 93–97.
persisted after adjustment for each of these factors. Abstract: PURPOSE: To examine infant feeding
We found no clear association between duration of practices at one to two months of age and at four
158
to six months in a rural population of infants at future research on interventions during labor and
risk for failure to thrive. DESIGN: A descriptive/ its effect on breastfeeding initiation can be
exploratory study with 52 mothers who were compared.
interviewed twice during the infant’s first six
months of life. Mothers were recruited from health
care facilities in rural southeastern Kentucky. Berra, S., L. Rajmil, R. Passamonte, E. Fernandez,
Mothers participated in two structured interviews and J. Sabulsky. 2001. “Premature cessation of
about feeding practices conducted in health care breastfeeding in infants: development and
clinics or in the home. RESULTS: At birth 52% of evaluation of a predictive model in two
mothers chose to use formula, 41.2% chose Argentinian cohorts: the CLACYD study,
breastfeeding, and 8% were both breastfeeding and 1993–1999. Cordoba Lactation, Feeding,
formula feeding. By one month, 71% of mothers Growth and Development study,” Acta
were formula feeding and only 29% were Paediatr., vol. 90, no. 5, pp. 544–551.
breastfeeding. At four to six months postpartum Abstract: The objective of this study was to
80% of mothers were formula feeding and 20% develop a model to predict premature cessation of
were breastfeeding. Mothers with more children, breastfeeding of newborns, in order to detect at-
higher family income, and more education were risk groups that would benefit from special
more likely to breastfeed. Almost all mothers began assistance programs. The model was constructed
solid foods before the infant was four months old. using 700 children with a birthweight of 2,000g or
Infants were fed table foods including mashed more, in two representative cohorts in 1993 and
potatoes and gravy, and beverages such as apple 1995 (CLACYD I sample) in Cordoba, Argentina.
juice, fruit juices, and soda. Mothers relied on Data were analyzed from 632 of the cases.
health professionals for support for feeding Mothers were selected during hospital admittance
decisions at the first interview; however, they relied for childbirth and interviewed in their homes at 1
more on the grandmother for support at the time month and 6 months. To evaluate the model, an
of the second interview. CONCLUSIONS AND additional sample with similar characteristics was
CLINICAL IMPLICATIONS: Breastfeeding drawn during 1998 (CLACYD II sample). A
mothers need additional support to continue questionnaire was administered to 347 mothers
breastfeeding beyond the first month. Mothers and during the first 24–48 hours after birth and a
grandmothers need education to discourage the follow-up was completed at six months, with
practice of early introduction of inappropriate solid weaning information on 291 cases. Premature
foods, including the practice of thickening bottles cessation of breastfeeding was considered when it
of formula with cereal. Nutrition teaching should occurred prior to six months. A logistic regression
be provided to mothers and grandmothers model was fitted to predict premature end of
including how to select high nutrient, lower fat- breastfeeding, and was applied to the CLACYD II
weaning foods, and limiting infant intake of high- sample. The calibration (Hosmer-Lemeshow C
calorie drinks. statistic) and the discrimination [area under the
receiver operating characteristics (ROC) curve] of
159
prevent its general use at a population level, it may hyperbilirubinemia was also strongly associated
be a useful tool in the identification of women with with delivery by vacuum extractor, some perinatal
a high probability of early weaning. complications (cephalohematoma, positive
Coombs’ test, and blood group systems of A, AB,
B, and O [ABO] incompatibility) and Asian origin.
Bertini, G., C. Dani, M. Tronchin, and F. F. Multiple logistic regression analysis shows that
Rubaltelli. 2001. “Is breastfeeding really supplementary feeding, weight loss percentage,
favoring early neonatal jaundice?” Pediatr., ABO incompatibility, and vacuum extraction
vol. 107, no. 3, p. E41. significantly increase the risk of jaundice, while
Abstract: OBJECTIVE: The purpose of this study only cesarean section decreases the risk.
was to evaluate the development of significant CONCLUSION: The present study confirms the
hyperbilirubinemia in a large unselected newborn important role of fasting in the pathogenesis of
population in a metropolitan area with particular neonatal hyperbilirubinemia, although
attention to the relationship between type of breastfeeding per se does not seem related to the
feeding and incidence of neonatal jaundice in the increased frequency of neonatal jaundice but to the
first week of life. STUDY DESIGN: A population higher bilirubin level in a very small subpopulation
of 2,174 infants with gestational age >/=37 weeks of infants with jaundice. In fact, in the breastfed
was prospectively investigated during the first days infants, there is a small subpopulation with higher
of life. Total serum bilirubin determinations were serum bilirubin levels. These infants, when starved
performed on infants with jaundice. The following and/or dehydrated, could probably be at high risk
variables were studied: type of feeding, method of of bilirubin encephalopathy.
delivery, weight loss after birth in relationship to
the type of feeding, and maternal and neonatal risk
Betran, A. P., M. de Onis, J. A. Lauer, and J. Villar
factors for jaundice. Statistical analyses were
2001. “Ecological study of effect of breast
performed using the z-test for parametric variables
feeding on infant mortality in Latin America,”
and the t-test for nonparametric variables. In
BMJ, vol. 323, no. 7308, pp. 303–306.
addition, the multiple logistic regression allows for
the estimation of the role of the individual Abstract: OBJECTIVE: To estimate the effect of
characteristics in the development of exclusive breastfeeding and partial breastfeeding on
hyperbilirubinemia. Data concerning serum infant mortality from diarrheal disease and acute
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
bilirubin peak distribution in jaundiced newborns respiratory infections in Latin America. DESIGN:
were analyzed using a single and a double Attributable fraction analysis of national data on
Gaussian best fit at least squares. The t-test was infant mortality and breastfeeding. SETTING:
performed to compare two values (high and low) Latin America and the Caribbean. MAIN
of the serum bilirubin peak in breastfed and OUTCOME MEASURES: Mortality from diarrheal
supplementary-fed infants with those in bottle-fed disease and acute respiratory infections and
infants. RESULTS: The maximal serum bilirubin nationally representative breastfeeding rates.
concentration exceeded 12.9mg/dL RESULTS: Fifty-five percent of infant deaths from
(221 micromol/L) in 112 infants (5.1%). The study diarrheal disease and acute respiratory infections in
demonstrated a statistically significant positive Latin America are preventable by exclusive
correlation between patients with a total serum breastfeeding among infants aged zero to three
bilirubin concentration >12.9mg/dL months and partial breastfeeding throughout the
(221 micromol/L) and supplementary feeding; remainder of infancy. Among infants aged zero to
oppositely, breastfed neonates did not present a three months, 66% of deaths from these causes are
higher frequency of significant hyperbilirubinemia preventable by exclusive breastfeeding; among
in the first days of life. However, best Gaussian infants aged 4–11 months, 32% of such deaths are
fitting of our data suggests that a small preventable by partial breastfeeding. 13.9% of
subpopulation of breastfed infants have a higher infant deaths from all causes are preventable by
serum bilirubin peak than do bottle-fed infants. these breastfeeding patterns. The annual number of
Newborns with significant hyperbilirubinemia preventable deaths is about 52,000 for the region.
underwent a greater weight loss after birth CONCLUSIONS: Exclusive breastfeeding of
compared with the overall studied population, and infants aged 0–3 months and partial breastfeeding
infants given mixed feeding lost more weight than throughout the remainder of infancy could
breastfed and formula-fed newborns, indicating substantially reduce infant mortality in Latin
that formula has been administered in neonates America. Interventions to promote breastfeeding
who had a weight loss beyond a predetermined should target younger infants.
percentage of birthweight. Significant
160
Brahmbhatt, H. and R. H. Gray, 2003. “Child identified by thrice-weekly, community-based
mortality associated with reasons for non- surveillance. All infants were initially breastfed, but
breastfeeding and weaning: is breastfeeding best only 12% were exclusively breastfed at one month
for HIV-positive mothers?” AIDS, vol. 17, of age. At 12 months of age, 86% of children still
no. 6, pp. 879–885. received some breastmilk. Incidence and prevalence
rates of diarrhea in infants younger than six
Abstract: OBJECTIVE: To estimate child mortality
months of age were less among those who were
associated with reasons for the non-initiation of
exclusively breastfed compared with those who
breastfeeding and weaning caused by preceding
received other liquids or artificial milks in addition
morbidity, compared with voluntary weaning as a
to breastmilk. The diarrheal prevalence rates
result of maternal choice. METHODS:
doubled with the addition of these other fluids
Demographic and Health Surveys were analyzed
(15.2% vs. 7.1% of days ill, P<.001). Infants for
from 14 developing countries. Women reported
whom breastfeeding was discontinued during the
whether they initiated lactation or weaned, and if
first six months had 27.6% diarrheal prevalence.
so, their reasons for non-initiation or stopping
During the second six months of life,
breastfeeding were classified as voluntary choice or
discontinuation of breastfeeding was also
as a result of preceding maternal/infant illness.
associated with an increased risk of diarrheal
Rates of child mortality and survival analyses were
incidence and prevalence. Upper and lower
estimated, by reasons for non-breastfeeding or
respiratory tract infections occurred with lesser
weaning. RESULTS: Mortality was highest among
prevalence among exclusively breastfed younger
never-breastfed children. Child mortality among
infants. The prevalences of skin infections by
women who never initiated breastfeeding was
category of feeding practice were not as consistent,
significantly higher than among women who
but exclusively breastfed infants tended to have
weaned. Preceding maternal/infant morbidity was
fewer skin infections during the initial months of
the most common reason for not breastfeeding
life and older infants who continued to breastfeed
(63.9%), and the mortality of children never
had fewer infections than those who did not. None
breastfed because of preceding morbidity was
of the results could be explained by differences in
higher than in children not breastfed as a result of
the socioeconomic status of the infants’ families.
maternal choice; 326.8 per 1,000 versus 34.8 per
1,000, respectively. Mortality among breastfed
children who were weaned because of preceding Buescher, E. S. and P. S. Hair. 2001. “Human milk
morbidity was higher than among those weaned anti-inflammatory component contents during
voluntarily; 19.2 per 1,000 versus 9.3 per 1,000, acute mastitis,” Cell Immunol., vol. 210, no. 2,
respectively. Failure to initiate lactation was pp. 87–95.
significantly more frequent among women
reporting complications of delivery and with low Abstract: Mastitis is a common complication of
birthweight infants. CONCLUSION: Child human lactation. We examined milk specimens from
mortality as a result of the voluntary non-initiation eight women with clinical mastitis to determine their
of breastfeeding or voluntary weaning was lower content of anti-inflammatory components.
161
characteristics of normal milk, with elevations in Abstract: Thirty-one physicians, 108 nurses,
selected components/activities that may help protect 105 medical students, and 126 student nurses
the nursing infant from developing clinical illness practicing in the same medical center received a
due to feeding on mastitis milk. questionnaire to evaluate their knowledge and
attitudes about breastfeeding. The mean knowledge
score of the 139 staff member was 49.4 +/– 10.8
Byrd, T. L., H. Balcazar, and R. A. Hummer. 2001. (the highest possible score was 73); that of the
“Acculturation and breast-feeding intention and medical students was 31.2 +/– 8.9, and that of the
practice in Hispanic women on the US-Mexico nurse students was 39.5 +/– 7.6. Thirteen percent
border,” Ethn. Dis., vol. 11, no. 1, pp. 72–79. of the medical students vs. 68.6% of the student
Abstract: OBJECTIVES: To explore the extent to nurses reported that they had received
which acculturation indicators predict both breastfeeding education in school. All of the
breastfeeding history and intentions among respondents had a positive attitude toward
Mexican-American mothers having their first breastfeeding. Occupation and in-service education
births, and among those having subsequent births. for breastfeeding could increase the knowledge
DESIGN: Cross-sectional survey in a hospital score. Having been breastfed during infancy could
postpartum unit. METHODS: Three thousand and increase both the knowledge score and positive
thirty-six Hispanic women were interviewed attitude score. We suggest that breastfeeding be
postpartum in their hospital room. A survey was integrated into the curricula of both medical and
administered in English or Spanish, and included nursing schools. Health professionals should
questions about prenatal care, diet, work receive in-service education. The mechanism of
exposures, contraceptive use, and breastfeeding lactation, management of breast problems and
history and intentions. For the purposes of this infant problems, contraindications for
study, acculturation was measured using a series of breastfeeding, the properties of human milk and
indicators including language spoken at home, the benefits of breastfeeding for the infant should
language ability, country of birth, and country in all be included.
which last schooling was received. RESULTS:
Previous breastfeeding was significantly associated
Chezem, J., C. Friesen, and J. Boettcher. 2003.
with educational attainment, speaking both English
“Breastfeeding knowledge, breastfeeding
and Spanish at home, having had prenatal care
confidence, and infant feeding plans: effects on
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
162
actual lactation duration (r=.455; p=.0001). Dearden, K. A., l. N. Quan, M. Do, D. R. Marsh,
Compared with women planning to exclusively H. Pachon, D. G. Schroeder, and T. T. Lang.
breastfeed their infants, those planning to 2002. “Work outside the home is the primary
combination feed planned shorter breastfeeding barrier to exclusive breastfeeding in rural Viet
duration (p=.022), reported shorter actual duration Nam: insights from mothers who exclusively
(p=.004), and were less likely to meet their breastfed and worked,” Food Nutr. Bull.,
breastfeeding goal (p=.034). The variables maternal vol. 23, no. 4, pp. 101–108.
education, breastfeeding knowledge, and weeks of
Abstract: This study assessed barriers to exclusive
daily human milk substitute feeding were used to
breastfeeding in rural Viet Nam and identified how
develop a prediction equation that correctly
a few mothers were able to exclusively breastfeed
categorized 93% of participants who met their
despite barriers. A cross-sectional quantitative and
breastfeeding goal and 90% of those who did not.
qualitative assessment was carried out among
CONCLUSIONS: Expectations and the actual
120 mothers of infants less than six months old in
breastfeeding experience differed among women
northern Viet Nam. Only 24% of the mothers
planning to combination feed and those planning to
exclusively breastfed. Adjusting for infant’s age and
exclusively breastfeed. Whether a cause or
who attended delivery, the risk of not exclusively
consequence, daily human milk substitute feeding
breastfeeding was 14.0 times greater for women
was associated with negative breastfeeding
who had returned to work than for women who
outcomes.
had not. Exclusively breastfeeding mothers (n=4)
who worked differed from other mothers in
Costello, A. and H. S. Sachdev. 1998. “Protecting important ways. They all felt they had enough
breast feeding from breast milk substitutes,” milk, all knew the appropriate time to introduce
BMJ, vol. 316, no. 7138, pp. 1103–1104. foods and liquids, and most were supported in
their breastfeeding decisions by commune health
Abstract: Jacobs (of the Infant and Dietetic Foods workers and family members. This research
Association) and Bronner (of the International suggests strategies that can be implemented now to
Association of Infant Food Manufacturers) object increase exclusive breastfeeding in rural work
to a peer-reviewed interagency study of widespread environments. These include improving knowledge
violations of the international code of the World about the introduction of water and semi-solids,
Health Organization (WHO) regarding marketing addressing perceptions of milk insufficiency,
of breastmilk substitutes. They say that the study securing support from others, and presenting
has been severely criticized, but provide no mothers with options for exclusively breastfeeding,
published peer-reviewed references in support of even when they work outside the home.
this. They say that the code does not apply to
follow-on formulas, but the code specifically states
that it applies to any product marketed to replace Donnelly, A., H. M. Snowden, M. J. Renfrew, and
breastmilk, partially or totally. They seek to avoid M. W. Woolridge. 2000. “Commercial hospital
honoring the code by citing local regulations. discharge packs for breastfeeding women,”
163
Group and CINAHL and MEDLINE. SELECTION education are the major factors that tend to shorten
CRITERIA: All randomized controlled trials with breastfeeding. Nevertheless recent trends show an
or without blinding to examine the effects of increase in early initiation and in duration of
commercial discharge packs on breastfeeding. breastfeeding as a result of promotion efforts
Participants: Consenting postpartum women who deployed by WHO and Unicef, local governments,
initiate breastfeeding while in hospital or and non-governmental organizations. The
immediately upon discharge. Interventions: importance of breastmilk as a food resource of
Commercial discharge packs which contain free African countries is generally not recognized. In
samples of infant formula or promotional material 31 countries where data on prevalence of
versus non commercial discharge packs (specifically breastfeeding are available, consumption of
those from which free samples of infant formula breastmilk by children under three years is
have been removed or have been replaced with e.g., estimated at 3.5 million tons per year. The AIDS
breast pads) or no pack. Main outcome measures: epidemic could threaten breastfeeding because the
The proportion of women breastfeeding at six virus can be transmitted through breastmilk, as
weeks and three months (13 weeks) postpartum. demonstrated by numerous studies. A study
Other outcomes: Rates of breastfeeding at other suggests that feeding breastmilk and other liquids to
fixed time points between zero and six months infants could be the feeding mode associated with
postpartum. DATA COLLECTION AND the highest rate of transmission. To prevent mother-
ANALYSIS: Data were extracted by one reviewer to-child transmission of HIV, WHO recommends
and checked by a second reviewer. MAIN replacement feeding if it is feasible and safe.
RESULTS: Nine randomized controlled trials Otherwise, mothers are encouraged to practice
involving a total of 3,730 women were analyzed. exclusive breastfeeding for the first months of life
The studies only included women from North followed by early and rapid weaning. The feasibility
America. The meta-analysis showed that when of replacement feeding with breastmilk substitutes,
comparing commercial discharge packs with any of however, is very uncertain. In a study where free
the controls (no intervention, non-commercial pack substitutes were given to HIV-positive mothers, the
and combinations of these), exclusive breastfeeding mortality of the formula-fed infants was the same as
was reduced at all time points in the presence of that of the breastfed infants. HIV-positive mothers
commercial hospital discharge packs. There was no may find it difficult to cope with the constraints of
evidence to support the conjecture that use of replacement feeding, in terms of cost, workload and
hospital discharge packs causes the early time, and with the additional health care needs of
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
165
Abstract: BACKGROUND: The protective effect of Goksen, F. 2002. “Normative vs. attitudinal
breastfeeding on the development of childhood considerations in breastfeeding behavior:
asthma remains a matter of controversy. We multifaceted social influences in a developing
conducted a systematic review of prospective country context,” Soc. Sci. Med., vol. 54,
studies that evaluated the association between no. 12, pp. 1743–1753.
exclusive breastfeeding during the first three
Abstract: The aim of the paper is to test the basic
months after birth and asthma. STUDY DESIGN:
assumptions underlying the theory of reasoned
We searched the 1966–1999 MEDLINE database
action (TRA) for exclusive breastfeeding behavior
and reviewed reference lists of relevant articles to
taking place in the rather complicated social
identify 12 prospective studies that met pre-stated
environment of women who have just given birth.
inclusion criteria. Methodological aspects of the
The paper aims (i) to argue that normative rather
studies, duration and exclusivity of breastfeeding,
than attitudinal considerations are more important
and outcomes were assessed. Effect estimates were
in engaging the correct breastfeeding behavior, and
abstracted by the investigators, using a
(ii) to demonstrate that the TRA concept of social
standardized approach. RESULTS: The summary
norm should be treated as a multi-layered construct
odds ratio (OR) for the protective effect of
which involves several enabling factors in
breastfeeding was 0.70 (95% CI: 0.60 to 0.81).
predicting complex behaviors such as
The effect estimate was greater in studies of
breastfeeding. Data were collected in three phases
children with a family history of atopy (OR=0.52)
as part of a prospective cohort follow-up design.
than in studies of a combined population
The first phase of data collection was conducted in
(OR=0.73). CONCLUSIONS: Exclusive
the hospital with mothers after the delivery. Two
breastfeeding during the first months after birth is
follow-up questionnaires were administered at the
associated with lower asthma rates during
end of the first and second months. Results did not
childhood. The effect, caused by
confirm the assertions of the TRA. Logistic
immunomodulatory qualities of breastmilk,
regression models and multiple regression analyses
avoidance of allergens, or a combination of these
indicated that intention and belief/attitude
and other factors, strengthens the advantage of
measures taken at the time of birth did not predict
breastfeeding, especially if a family history of atopy
end-of-first-month full breastfeeding behavior.
is present.
Overall, results revealed that intention by itself was
not a strong determinant of breastfeeding unless it
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
Gill, S. L. 2001. “The little things: perceptions of was conditioned by enabling factors such as social
breastfeeding support,” J. Obstet. Gynecol. support and subjective norms regarding
Neonatal Nurs., vol. 30, no. 4, pp. 401–409. breastfeeding.
166
mature milk that will be needed to protect against dietary iron supply. Although iron deficiency is a
a particular disorder, (4) whether non-maternal significant nutritional problem worldwide, most of
milk is as efficacious as maternal milk for these the adverse effects of iron deficiency in this age
infants, and (5) in view of the concern of potential group are hypothetical and rely on extrapolation
graft versus host reactions, whether it is desirable from animal studies or studies at different ages.
or contraindicated to maintain the leukocytes in This, however, also is true of most of the adverse
human milk used to feed premature infants. These effects of iron excess in this age group. Given this
questions are not easily answered, but will be uncertainty, it seems prudent to use the lowest dose
worthy considerations by neonatologists, clinical of iron that prevents iron-deficiency anemia.
immunologists, epidemiologists, and others who Currently, the best evidence is that this is achieved
are concerned with providing optimal by prolonged breastfeeding, avoidance of
nutritional/immunologic support for the premature unfortified formulas and cow’s milk, and the
infant. introduction of iron-fortified and vitamin C-
fortified weaning foods at approximately six
months of age. Despite much research, there are
Greer, F. R. 2001. “Do breastfed infants need many areas of uncertainty regarding iron
supplemental vitamins?” Pediatr. Clin. North supplementation of infants, including that: 1) The
Am., vol. 48, no. 2, pp. 415–423. optimal age for introducing iron-fortified
Abstract: Human milk will not meet the DRI for supplemental foods is poorly defined and should be
all vitamins in breastfeeding infants. The most further evaluated. 2) The natural history of iron
glaring discrepancy between intake and the RDA is deficiency and iron-deficiency anemia during the
for vitamin D, although, as discussed, infants may first year of life is unclear, as are the possible long-
synthesize this from sunlight exposure. Vitamin K term effects of this, especially on developmental
must be given in the newborn period. Deficiencies outcome. 3) The biologic variability among infants
of other vitamins are rare, especially if mothers are and among their mothers that allows many infants
nourished adequately. If breastfeeding infants are who do not receive iron-fortified foods to prevent
to be supplemented with vitamin D or any other iron deficiency while receiving only human milk
vitamins, the standard liquid preparations available throughout the first year of life is intriguing and
all contain large amounts of the water-soluble and warrants additional study. 4) The iron
fat-soluble vitamins (except for vitamin K), which requirements of small-for-gestational-age, term
more than meets the RDA. The milk content of infants are unknown. Their iron requirements are
thiamin, pyridoxine, and niacin is correlated highly likely to be higher than those of average term
with maternal intake, and these vitamins are all infants, but whether iron supplements are required
present in relatively large amounts in standard is unclear. 5) The optimum amount of dietary iron
multivitamin tablets given to lactating mothers. In in the weaning diet needs to be further defined.
conclusion, in healthy, breastfed infants of well- Similarly, the optimal source and amount of iron in
nourished mothers, there is little risk for vitamin infant formulas given to infants who receive a
deficiencies and the need for vitamin mixture of human milk and formula is unclear.
167
putting an ant into it to observe if it dies. The duration of five months. METHODS: Forty
condition of bad milk can be treated by various adjacent zones in Dhaka were randomized to
procedures. The findings are discussed in relation intervention or control groups. Women were
to similar ideas existing in other societies and to enrolled during the last trimester of pregnancy
views on the quality of maternal milk held in the between February and December, 1996. In the
industrialized countries. It is proposed that the idea intervention group, 15 home-based counseling
of producing bad milk may be an important visits were scheduled, with two visits in the last
determinant of breastfeeding performance trimester, three early postpartum (within 48 hours,
generally. Restrictions imposed on the breastfeeding on day 5, between days 10 and 14), and fortnightly
woman, with the intention of producing healthier thereafter until the infant was five months old. Peer
breastmilk, may actually contribute to a decline in counsellors were local mothers who received 10
breastfeeding. days’ training. FINDINGS: Three hundred and
sixty-three women were enrolled in each group.
Peer counseling significantly improved
Gupta, A., K. Khanna, and S. Chattree. 1999. breastfeeding practices. For the primary outcome,
“Cup feeding: an alternative to bottle feeding in the prevalence of exclusive breastfeeding at five
a neonatal intensive care unit,” J. Trop. months was 202/228 (70%) for the intervention
Pediatr., vol. 45, no. 2, pp. 108–110. group and 17/285 (6%) for the control group
Abstract: Cup feeding has been suggested as an (difference=64%; 95% CI: 57%–71%, p>0.0001).
alternative to bottle feeding to help promote For the secondary outcomes, mothers in the
breastfeeding by avoiding nipple confusion. To intervention group initiated breastfeeding earlier
demonstrate the possibility and utility of cup than control mothers and were less likely to give
feeding, records of 59 preterm and low birthweight prelacteal and postlacteal foods. At day 4,
babies (born before 37 weeks’ gestation) admitted significantly more mothers in the intervention
to a neonatal intensive care unit (NICU) from May group breastfed exclusively than controls.
1995 to April 1996 were analyzed. Feeding was INTERPRETATION: Peer counsellors can
initiated on cup if swallowing was present and cup effectively increase the initiation and duration of
feeding was possible as early as 29 weeks’ exclusive breastfeeding. We recommend
gestational age with a birthweight of 900g. In the incorporation of peer counsellors in mother and
case of five infants (38%) in the gestational age child health programs in developing countries.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
168
their infants exclusively for five months compared Abstract: Human breastmilk is primarily colostrum
to only 6% in the control area. The authors immediately following birth. Colostrum gradually
describe the peer counseling training, strategies changes to mature milk over the next several days.
used for peer counseling visits, and lessons learned. The role of colostrum in fighting infections and
promoting growth and development of the
newborn is widely acknowledged. This role is
Hall, R. T. 2001. “Nutritional follow-up of the mediated by differences across cultures in the
breastfeeding premature infant after hospital acceptability of colostrum and the prevalence of
discharge,” Pediatr. Clin. North Am., vol. 48, colostrum feeding. This study examined the
no. 2, pp. 453–460. prevalence of colostrum feeding and time to
Abstract: In summary, fortification of human milk initiation of breastfeeding in 143 rural Bangladeshi
may be beneficial in preterm infants, particularly women in Matlab thana. Structured interviews
those born at less than 34 weeks’ gestation or less were collected during a nine-month prospective
than 1,800g birthweight, during and after initial study conducted in 1993. Women were usually
hospitalization. This fortification after hospital interviewed within four days of giving birth and
discharge is more crucial for infants who cannot were asked about whether or not they fed their
consume ad libitum quantities of breastmilk, have child colostrum and the number of hours until they
poor growth, or have abnormalities in the began breastfeeding the baby. Ninety percent of the
biochemical screen of nutritional status. Although mothers reported feeding their newborn colostrum.
data indicate that in-hospital, short-term gains in A logistic regression found no effect on the
growth and mineral status are achieved, prevalence of colostrum feeding from the following
information is fragmentary regarding the influence covariates: mother’s age, parity, history of
on long-term growth and neurodevelopmental pregnancy loss, child’s sex, mother’s self-report of
outcomes of feeding supplemented human milk. delivery complications, and the time from birth to
Also, no data are available on outcomes when interview. Fifty-nine percent of mothers initiated
providing these mixtures to premature infants after breastfeeding within 4 hours, and 88% within
hospital discharge. It is recommended that a 12 hours of parturition. Survival analysis was used
nutritional survey be accomplished before and to estimate the effects of covariates on the time
approximately one month after discharge and that from delivery to initial breastfeeding. Time to
fortification or supplementation be initiated if an initial breastfeeding was delayed slightly, but
infant is failing to achieve normal growth and significantly, for older mothers, for male infants,
biochemical measures of nutrition. and by mothers who did not report delivery
complications. The percentage of mothers who fed
their child colostrum was higher, and times to
Heinig, M. J. 2001. “Host defense benefits of initial breastfeeding were shorter, than almost all
breastfeeding for the infant. Effect of previous reports from South Asia. These findings
breastfeeding duration and exclusivity,” Pediatr. might be explained, in part, by methodological
Clin. North Am., vol. 48, no. 1, pp. 105–23, ix. differences among studies, but it is suggested that
recent changes towards earlier initiation of
169
the same time mothers were questioned as to additional searches using the keywords developing
whether they had elected to provide expressed countries, colostrum, infant feeding and infant
breastmilk at birth and the total duration of mortality, hypoglycemia, hypothermia,
breastmilk feeding. RESULTS: Some 73% of breastfeeding practices, and suckling. FINDINGS:
mothers provided expressed breastmilk and 37% breastfeeding helps prevent hypothermia and
breastfed for four months or longer. Increasing hypoglycemia in newborn babies, which are
duration of breastmilk feeding was associated with contributory causes of early neonatal deaths
increases in both verbal IQ (p<0.001) and especially among low birthweight and premature
performance IQ (p<0.05): children breastfed for babies. During the late neonatal period, most
eight months or longer had mean (SD) verbal IQ deaths in developing countries are due to infections
scores that were 10.2 (0.56) points higher and such as sepsis, acute respiratory tract infection,
performance IQ scores that were 6.2 (0.35) points meningitis, omphalitis and diarrhea. Feeding
higher than children who did not receive colostrum and breastfeeding, especially exclusive
breastmilk. These differences were substantially breastfeeding, protects against such deaths. KEY
reduced after control for selection factors CONCLUSIONS AND IMPLICATIONS FOR
associated with receipt of breastmilk. Nevertheless, PRACTICE: In most developing countries, nearly
even after control for confounding, there remained all women breastfeed in the first month of life, but
a significant (p<0.05) association between often breastfeeding is delayed beyond the first hour
duration of breastmilk feeding and verbal IQ: after birth, and exclusive breastfeeding is not
children breastfed for eight months or longer had usually practiced. Policies and training of staff of
adjusted mean (SD) verbal IQ scores that were 6 maternity centers and hospitals can encourage early
(0.36) points higher than the scores of those who initiation of breastfeeding and exclusive
did not receive breastmilk. CONCLUSIONS: breastfeeding. Midwives can support community-
These findings add to a growing body of evidence based efforts to support exclusive breastfeeding.
to suggest that breastmilk feeding may have small Breastfeeding plays an important role in reducing
long-term benefits for child cognitive development. neonatal mortality and should be strongly
emphasized by programs attempting to reduce
neonatal mortality.
Howard, C. R. and R. A. Lawrence. 2001.
“Xenobiotics and breastfeeding,” Pediatr. Clin.
North Am., vol. 48, no. 2, pp. 485–504. Hylander, M. A., D. M. Strobino, and R.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
170
sepsis/meningitis (human milk [19.5%] vs. formula women. OBJECTIVE: To study pregnant women’s
[32.6%]) differed significantly by type of feeding. knowledge about general health care of newborns,
Major risk factors for infection were similar in including breastfeeding aspects. TYPE OF STUDY:
both groups. Human milk feeding was Cross-sectional. SETTING: Prof. Samuel Barnsley
independently correlated with a reduced odds of Pessoa Health School Center, Faculty of Medicine,
infection (odds ratio [OR]=0.43; 95% confidence University of Sao Paulo, Brazil. PARTICIPANTS:
interval [CI]: 0.23–0.81), controlling for All pregnant women who were registered in the
gestational age, five-minute Apgar score, prenatal care program during six consecutive
mechanical ventilation days, and days without months. MAIN MEASUREMENTS: Aspects of the
enteral feedings; and was independently correlated current gestation, previous gestations and
with a reduced odds of sepsis/meningitis childbirth, knowledge of the general aspects of
(OR=0.47, 95% CI: 0.23–0. 95), controlling for newborn health care and of breastfeeding practices.
gestational age, mechanical ventilation days, and RESULTS: The results show that only a little over
days without enteral feedings. CONCLUSIONS: half of the pregnant women had received any
The incidence of any infection and information on newborn health care.
sepsis/meningitis are significantly reduced in Misinformation was clearly present regarding
human milk-fed VLBW infants compared with proper care of the umbilical stump and the nature
exclusively formula-fed VLBW infants. of jaundice, and worst regarding how to treat oral
thrush and jaundice, and about vaccination. In
relation to breastfeeding, even though almost all
Ingram, J., M. Woolridge, and R. Greenwood. the pregnant women declared their intention to
2001. “Breastfeeding: it is worth trying with the breastfeeding, less than half had a concrete
second baby,” Lancet, vol. 358, no. 9286, response regarding how long to do it for. The low
pp. 986–987. rates obtained in the topics dealing with the
Abstract: Mothers who experience breastfeeding duration, nursing intervals and the attitude to be
difficulties with their first babies and give up taken towards hypogalactia show unfamiliarity
breastfeeding are less likely to breastfeed with the breastfeeding technique. The “weak milk”
subsequent babies than mothers who do not belief, the misinformation about contraceptive
experience such difficulties. We carried out a methods during breastfeeding and the cost of
longitudinal study of 22 mothers in which milk artificial formulas also have a negative impact on
output was measured at one week and four weeks this practice. CONCLUSIONS: Pregnant women’s
after giving birth to their first and second babies. knowledge of newborn health care is low, as much
Significantly more breastmilk was produced at one in the aspects of general care as in relation to the
week for the second lactation (an increase of 31% practice of breastfeeding. These findings must be
[95% CI: 11–51%]) and the net increase was taken into consideration in educative programs
greatest for those with the lowest milk output on promoting breastfeeding.
the first occasion (90% [30%–149%]). They spent
less time feeding their second baby (a decrease of
Kaufman, H., B. Skipper, L. Small, T. Terry, and
171
breastfeeding was seen, with only 23% of the Available from:
women in the lower literacy group exclusively AMREF Book Distribution Unit
breastfeeding during the first two months amref.bdu@amref.org
compared with 54% of women in the higher www.amref.org/publications.htm
literacy group. CONCLUSION: Many patients
need simpler health education materials
encouraging breastfeeding. These materials are Kinlay, J. R., D. L. O’Connell, and S. Kinlay. 2001.
needed both before and during pregnancy. “Risk factors for mastitis in breastfeeding
women: results of a prospective cohort study,”
Aust. N. Z. J. Public Health, vol. 25, no. 2,
Killersreiter, B., I. Grimmer, C. Buhrer, J. W. pp. 115–120.
Dudenhausen, and M. Obladen. 2001. “Early
Abstract: OBJECTIVES: To identify potential risk
cessation of breast milk feeding in very low
factors for the development of mastitis in
birthweight infants,” Early Hum. Dev., vol. 60,
breastfeeding women. METHODS: A prospective
no. 3, pp. 193–205.
cohort study with questionnaire and telephone
Abstract: This investigation was carried out to follow-up was conducted. Women were recruited
comparatively assess the duration of breastmilk after delivery at either the teaching hospital or the
feeding and to analyze risk factors for early only private hospital with an obstetric service
cessation of breastmilk feeding in term and very during May to December 1994 in Newcastle, New
preterm infants. A cohort study was performed in South Wales and were followed up at home for six
89 consecutive very low birthweight (VLBW) infants months. 1,075 breastfeeding women were recruited
(<1,500g) who survived for at least for one week, and were sent follow-up questionnaires at three,
and 177 term infants with birthweights >2,500g eight and 26 weeks post-delivery. RESULTS:
born in the same hospital matched for gender and Mastitis occurred in 20% (95% CI: 18%–22%) of
multiplicity. Median duration of breastmilk feeding, women during the first six months. Factors that
as determined from charts and questionnaires were statistically significantly and independently
mailed to the mothers at six and 12 months related to mastitis were: past history of mastitis
corrected age, was 36 days in VLBW infants, (adjusted Hazard Ratio=1.74, 1.07–2.81),
compared to 112 days in control infants university or college education (HR=1.93,
(P<0.0001). In both VLBW and control infants, 1.18–3.16), blocked duct (HR=2.43, 1.68–3.49),
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
smoking during pregnancy, low maternal and low cracked nipples (HR=1.44, 1.00–2.07), use of
paternal school education were each significantly creams on nipples (HR=1.83, 1.22–2.73),
associated with short duration of breastmilk particularly papaya cream (Relative Risk=1.83,
feeding. In VLBW infants, multiple pregnancy and 1.36–2.47), and always starting with the alternate
gestational age <29 weeks were each associated with breast on consecutive feeds (HR=2.28, 1.50–3.44).
prolonged breastmilk feeding, as were maternal age CONCLUSIONS: Women with a past history of
>35 years and spontaneous pregnancy (as opposed mastitis had an increased risk of developing
to pregnancy following infertility treatment) in term mastitis. Blocked ducts and cracked nipples serve
infants. Multivariate analysis revealed that VLBW, as warning signs for mastitis. Use of some creams
smoking and low parental school education were may increase the risk of mastitis and their value
independent negative predictors of breastmilk should be tested in clinical trials. IMPLICATIONS:
feeding. While these results emphasize the need for We have identified several pre-natal and post-natal
special support of VLBW infant mothers promoting markers for increased risk of mastitis that may
lactation, the relationships between smoking, school assist in its early identification and treatment. The
education and breastmilk feeding in both strata use of creams on nipples may introduce pathogens
show that efforts to increase breastmilk feeding that cause mastitis and should be avoided.
require a public health perspective.
Kramer, M. S., B. Chalmers, E. D. Hodnett, Z.
King, S. 1992. Helping mothers to breastfeed (1st Sevkovskaya, I. Dzikovich, S. Shapiro, et al.
edition) AMREF (African Medical and 2001. “Promotion of Breastfeeding Intervention
Research Foundation). Trial (PROBIT): a randomized trial in the
Republic of Belarus,” JAMA, vol. 285, no. 4,
Abstract: This book summarizes the most up-to-
pp. 413–420.
date ideas about breastfeeding and gives practical
guidance on how to prevent problems. There is Abstract: CONTEXT: Current evidence that
also information about the lactational amenorrhea breastfeeding is beneficial for infant and child
method. health is based exclusively on observational studies.
172
Potential sources of bias in such studies have led to Kramer, M. S., R. G. Barr, S. Dagenais, H. Yang, P.
doubts about the magnitude of these health Jones, L. Ciofani, and F. Jane. 2001. “Pacifier
benefits in industrialized countries. OBJECTIVE: use, early weaning, and cry/fuss behavior: a
To assess the effects of breastfeeding promotion on randomized controlled trial,” JAMA, vol. 286,
breastfeeding duration and exclusivity and no. 3, pp. 322–326.
gastrointestinal and respiratory infection and
Abstract: CONTEXT: The World Health
atopic eczema among infants. DESIGN: The
Organization and the United Nations Children’s
Promotion of Breastfeeding Intervention Trial
Fund strongly discourage use of pacifiers because of
(PROBIT), a cluster-randomized trial conducted
their perceived interference with breastfeeding.
June 1996–December 1997 with a one-year follow-
Observational studies have reported a strong
up. SETTING: Thirty-one maternity hospitals and
association between pacifier use and early weaning,
polyclinics in the Republic of Belarus.
but such studies are unable to determine whether
PARTICIPANTS: A total of 17,046 mother-infant
the association is causal. OBJECTIVES: To test
pairs consisting of full-term singleton infants
whether regular pacifier use is causally related to
weighing at least 2,500g and their healthy mothers
weaning by three months postpartum and to
who intended to breastfeed, 16,491 (96.7%) of
examine differences in results according to
which completed the entire 12 months of follow-
randomized intervention allocation vs. observational
up. INTERVENTIONS: Sites were randomly
use or nonuse of pacifiers. DESIGN: Double-blind,
assigned to receive an experimental intervention
randomized controlled trial conducted from January
(n=16) modeled on the Baby-Friendly Hospital
1998 to August 1999. SETTING: Postpartum unit
Initiative of the World Health Organization and
of a university teaching hospital in Montreal,
United Nations Children’s Fund, which emphasizes
Quebec. PARTICIPANTS: A total of 281 healthy,
health care worker assistance with initiating and
breastfeeding women and their healthy, term
maintaining breastfeeding and lactation and
singleton infants. INTERVENTIONS: Participants
postnatal breastfeeding support, or a control
were randomly allocated to one of two counseling
intervention (n=15) of continuing usual infant
interventions provided by a research nurse trained in
feeding practices and policies. MAIN OUTCOME
location counseling. The experimental intervention
MEASURES: Duration of any breastfeeding,
(n=140) differed from the control (n=141) by
prevalence of predominant and exclusive
recommending avoidance of pacifier use and
breastfeeding at three and six months of life and
suggesting alternative ways to comfort a crying or
occurrence of one or more episodes of
fussing infant. MAIN OUTCOME MEASURES:
gastrointestinal tract infection, two or more
Early weaning, defined as weaning within the first
episodes of respiratory tract infection, and atopic
three months, compared between groups; 24-hour
eczema during the first 12 months of life,
infant behavior logs detailing frequency and
compared between the intervention and control
duration of crying, fussing, and pacifier use at four,
groups. RESULTS: Infants from the intervention
six, and nine weeks. RESULTS: A total of
sites were significantly more likely than control
258 mother-infant pairs (91.8%) completed follow-
infants to be breastfed to any degree at 12 months
up. The experimental intervention increased total
(19.7% vs. 11.4%; adjusted odds ratio [OR]=0.47;
175
Lucas, A., O. G. Brooke, R. Morley, T. J. Cole, extend the duration of exclusive breastfeeding, the
and M. F. Bamford. 1990. “Early diet of timing of the intervention is critical. Women must
preterm infants and development of allergic or be reached early during the prenatal period,
atopic disease: randomized prospective study,” supported at birth, and within the first month
BMJ, vol. 300, no. 6728, pp. 837–840. postpartum when breastfeeding problems and the
shift from exclusive to partial breastfeeding are
Abstract: OBJECTIVE: To study the effect of early
most likely to occur. The challenge ahead is to
diet on the development of allergic reactions in
implement infant feeding counseling and support in
infants born preterm. DESIGN: Two randomized
health services and community-based programs.
prospective trails. In trail A infants were randomly
Research is needed to answer questions such as
allocated banked donor milk or preterm formula as
what is the most cost-effective method of training
their sole diet or (separately randomized) as a
and the number and timing of visits? What are the
supplement to their mother’s expressed breastmilk.
most important messages for a mother to have and
In trial B infants were allocated term or preterm
how are they best delivered to her? It is also
formula. A blind follow up examination was done
necessary to start thinking and acting on the
18 months after the expected date of birth.
concept of infant feeding promotion activities.
SETTING: Neonatal units of hospitals in
Research must emphasize not only the efficacy and
Cambridge, Ipswich, King’s Lynn, Norwich, and
effectiveness of the promotion of optimal infant
Sheffield. Outpatient follow up. PARTICIPANTS:
feeding behaviors on infant health, but also its
777 Infants with a birthweight less than 1,850g
cost-effectiveness. It is necessary to involve health
born during 1982 to 1984. MAIN OUTCOME
economists in future research. Lastly, to ensure that
MEASURES: Development of eczema, allergic
the numerous benefits of human milk and
reactions to food or drugs, and asthma or
breastfeeding on infant survival, health, and
wheezing by nine and 18 months after term.
development are achieved, the potential synergies
Whenever possible the observations were
between research and the implementation and
confirmed by rechallenge or clinical examination.
evaluation of interventions based on this research
RESULTS: At 18 months after term there was no
must be realized. To do this not only requires
difference in the incidence of allergic reactions
sound scientific research, but also the linking of
between dietary groups in either trial. In the
this research to the science of public health
subgroup of infants with a family history of atopy,
intervention and the development of creative
however, those in trial A who received preterm
methodologies to evaluate multi-faceted
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
176
factors. Parameters evaluated were the volume cupfeedings, premature infants are more
ingested, duration of the feed, degree of spilling physiologically stable, with lower heart rates,
and satiety. Results: The infants took the maximum higher oxygen saturations, and less desaturations,
volume in the least time and kept quiet longest than during bottlefeedings. However, cupfed
with the paladai. The findings were particularly infants took less volume, over more time, than
significant in the group including all the categories bottlefed for these initial feedings. Based on better
of infants. Spilling was the highest with the cup, physiologic stability and no difference in untoward
especially with preterm infants. effects, cupfeeding is at least as safe, if not safer,
than bottlefeeding in this population. This study
supports the use of cupfeeding as a safe alternative
Marinelli, K. A., G. S. Burke, and V. L. Dodd. feeding method for premature infants learning to
2001. “A comparison of the safety of breastfeed.
cupfeedings and bottlefeedings in premature
infants whose mothers intend to breastfeed,” J.
Perinatol., vol. 21, no. 6, pp. 350–355. Maza, I. d., et al. 1997. Sustainability of a
community-based mother-to-mother support
Abstract: OBJECTIVE: To compare the safety of
project in the peri-urban areas of Guatemala
cupfeeding, an alternative feeding method, to
City: a La Leche League study.
bottlefeeding, the current standard of artificial
feeding in the United States, in preterm infants Abstract: This study examines the sustainability of
whose mothers intend to breastfeed. STUDY a Guatemala City periurban project to train
DESIGN: In a prospective, randomized crossover breastfeeding counselors (BFCs) and to sustain a
study, 56 infants < or = 34 weeks at birth, whose mother-to-mother network for encouraging
mothers indicated a desire to breastfeed, were breastfeeding with help from La Leche League
studied. Skin-to-skin care and attempts at breast Guatemala (LLLG). BASICS provided funding for
were encouraged frequently when babies were the evaluation. Data were obtained from surveys
physiologically stable. When infants were among a sample of women living in El Limon
> or = 34 weeks’ corrected gestational age, the conducted in March–April 1996, structured
order of the first two non-breast oral feedings was interviews among BFCs, and administrative and
randomized by coin toss to one cupfeeding and one financial records from LLLG. The program was
bottlefeeding. Trained Neonatal Intensive Care begun in 1988 with the help of USAID and the
Unit nurses provided the feedings. Heart rate, International La Leche League to implement a
respiratory rate, and oxygen saturation were community-based mother-to-mother support
recorded at one-minute intervals for 10 minutes program in poor periurban areas of Guatemala
before and during the feeding. Volume taken, time City. USAID funding ended in 1992, and the LLLG
required to complete the feed, and any apnea, continued the project. In 1992, the program
bradycardia, choking, or spitting episodes were operated in 10 communities without coordinators
recorded. RESULTS: Heart rate (p<0.0001) and and with about 141 BFCs, seven paid LLLG staff
respiratory rate (p<0.0001) increased and oxygen working half-time, and an annual budget of U.S.
177
workshops and refresher training. It is emphasized after delivery. The skin-to-skin contact after birth
that women were most concerned about physical significantly coexisted with the other hospital
and economic survival and not health. The practices supportive to breastfeeding, especially
program would improve by coordinating better rooming-in without separation longer than 1 hour
with local health systems. per 24 hours [relative risk (RR)=3.18, 95%
confidence interval (95%) CI: 2.34–4.31] and first
Available at:
breastfeeding within two hours after birth
Wellstart BASICS
(RR=2.94, 95% CI: 2.36–3.67). Multivariate
www.basics.org
analysis performed by a general linear model with
duration of exclusive breastfeeding as the
McIntyre, E., J. E. Hiller, and D. Turnbull. 2001. dependent variable indicated skin-to-skin contact
“Attitudes towards infant feeding among adults and mother education as two independent variables
in a low socioeconomic community: what social influencing the duration of exclusive breastfeeding.
support is there for breastfeeding?” Breastfeed. CONCLUSION: The results indicate that extensive
Rev., vol. 9, no. 1, pp. 13–24. mother-infant skin-to-skin contact lasting for
longer than 20 minutes after birth increases the
Abstract: An analysis of the role of social support duration of exclusive breastfeeding.
in influencing breastfeeding in a low
socioeconomic area in South Australia was
undertaken by examining infant feeding attitudes Morris, S. S., S. M. Grantham-McGregor, P. I. Lira,
and experiences of mothers, fathers and A. M. Assuncao, and A. Ashworth. 1999.
grandmothers as well as the general community. A “Effect of breastfeeding and morbidity on the
random telephone survey of over 3,400 adults development of low birthweight term babies in
(including a more extensive survey of 373 Brazil,” Acta Paediatr., vol. 88, no. 10,
mothers, fathers and grandmothers in the sample) pp. 1101–1106.
in this area indicated that there was little support
Abstract: Low birthweight (LBW) occurs in 17%
for breastfeeding compared to bottle-feeding with
of births in developing countries and many of them
similar barriers to breastfeeding found in all target
are full term. The subsequent development of LBW
groups as well as the general community. These
term infants is poorer than higher birthweight
included breastfeeding in public, the convenience
children and more likely to be affected by poor
of bottle-feeding, maternal discomfort of
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
Narayanan, I., B. Singh, and D. Harvey. 1984. Narayanan, I., K. Prakash, R. K. Verma, and V. V.
“Fat loss during feeding of human milk,” Arch. Gujral. 1983. “Administration of colostrum for
Dis. Child, vol. 59, no. 5, pp. 475–477. the prevention of infection in the low
Abstract: A rise in the fat concentration of human birthweight infant in a developing country,” J.
milk within the syringe was noted towards the end Trop. Pediatr., vol. 29, no. 4, pp. 197–200.
179
Abstract: The efficacy of limited volumes of Abstract: The BFHI is a global UNICEF/WHO-
colostrum (10mL) administered three times a day sponsored effort to promote breastfeeding by
in the prevention of infection was evaluated in ensuring that all women are provided with sound
33 high-risk low birthweight infants (group I) who information regarding their infant feeding choices
were compared with 33 matched controls (group and that those who elect to breastfeed their infants
II). Infections were found to be significantly less are given physiologically sound, evidence-based
(p<0.01) in group I. advice and skilled assistance prenatally and as they
begin nursing their infants during their postpartum
hospital or birth center stay. The initiative is based
Narayanan, I., K. Prakash, S. Bala, R. K. Verma, on ten policy or procedure statements, The Ten
and V. V. Gujral. 1980. “Partial Steps, which were jointly developed and published
supplementation with expressed breast-milk for in 1989 by the sponsoring agencies in consultation
prevention of infection in low-birth-weight with international experts. In 1990, the Ten Steps
infants,” Lancet, vol. 2, no. 8194, pp. 561–563. were accepted as the central theme of the Innocenti
Abstract: In a prospective controlled study the anti- Declaration and, later that year, endorsed at the
infective properties of breastmilk were evaluated in World Summit on Children. In 1992, UNICEF and
70 high-risk low birthweight infants. Thirty-two WHO launched a major international campaign to
babies (group I) were given fresh expressed encourage all hospitals with maternity services to
breastmilk during the day and milk formula at accept the Ten Steps as basic maternity and
night. Thirty-eight infants (group II) received only newborn infant care policies and procedures. These
milk formula and served as controls. The two Ten Steps were reviewed briefly in this article.
groups were matched for other factors that could Official designation as Baby Friendly requires a
influence the occurrence of infection. The incidence careful assessment completed by a trained external
of infections was significantly less (p<0.01) in team to confirm that the institution is truly
babies who received breastmilk. carrying out all Ten Steps and conforming to the
International Code of Marketing of Breastmilk
Substitutes. During the eight years since the
Nascimento, M. B. and H. Issler. 2003. initiative began, more than 15,000 hospitals in 136
“Breastfeeding: making the difference in the countries have been designated as Baby Friendly.
development, health and nutrition of term and Twenty-seven of these officially designated
preterm newborns,” Rev. Hosp. Clin. Fac. Med. institutions are in the United States, where the
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
Sao Paulo, vol. 58, no. 1, pp. 49–60. campaign has been active only since 1996. The
Abstract: Breastfeeding is the natural and safe way BFHI is considered one of the most successful
of feeding small infants, providing nutritional, international efforts ever performed to protect,
immunological, psychological and economic promote, and support breastfeeding. Although it
recognized and unquestionable advantages. These does not ensure that mothers will aspire to or
qualities are especially important in premature achieve the widely accepted goal of approximately
infants, because of their vulnerability. Despite six months of exclusive breastfeeding, it helps
highly desirable, there is, in general, little success in mothers to initiate exclusive nursing, an essential
breastfeeding preterm infants, especially in special step in the right direction.
care neonatal units. There are evidences that a high
supportive hospital environment, with an Nikodem, C., L. Schelke, L. Enraght-Moony, and
interdisciplinary team, makes possible to these G. J. Hofmeyr. 1995. “Breastfeeding in crisis:
infants to be breastfed. In this article, the authors survey results of the Baby-Friendly Hospital
present an up-to-date review about the components Initiative,” Curationis., vol. 18, no. 3,
of human milk and its unique characteristics, as pp. 39–42.
well as describes aspects that make the breastmilk
particularly suitable for feeding the premature Abstract: OBJECTIVE: To assess current
newborn. breastfeeding practices in hospital in South Africa.
DESIGN: Survey conducted by means of a postal
questionnaire for hospitals and a questionnaire
Naylor, A. J. 2001. “Baby-Friendly Hospital based on the baby-friendly initiative action folder
Initiative. Protecting, promoting, and for mothers. SETTING: All private and provincial
supporting breastfeeding in the twenty-first hospitals according to the 1992 address list
century,” Pediatr. Clin. North Am., vol. 48, supplied by the Department of National Health:
no. 2, pp. 475–483. Readers of “Living and Loving” and breastfeeding
180
liaison groups. MAIN OUTCOME MEASURE: services in Australia. There is enough evidence to
The level of implementation of the “Ten Steps to support further breastfeeding health promotion
Successful Breastfeeding.” RESULTS: Less than half initiatives in Australia to ensure that all hospitals
of the responding hospitals reported having a become “baby friendly,” that all mothers are
written breastfeeding policy. Most hospitals have a encouraged and supported to commence
shortage of specialized training in the support of breastfeeding and that there is adequate
breastfeeding. This is consistent with the outcome community support for mothers to continue
of the maternal questionnaire indicating that the exclusive breastfeeding for at least the first six
average hospital is not baby friendly. months of life.
CONCLUSIONS: A concerted effort should be
made by hospitals to implement the “Ten Steps to
Successful Breastfeeding” and attention should be Ojofeitimi, E. O., O. O. Owolabi, J. T. Eni-
given to building breastfeeding skills into the Olorunda, O. F. Adesina, and O. A. Esimai.
curriculum for medical students, nurses and allied 2001. “Promotion of exclusive breastfeeding
disciplines as well as in-service training for current (EBF): the need to focus on the adolescents,”
health care workers. Nutr. Health, vol. 15, no. 1, pp. 55–62.
Abstract: This study was designed to assess the
knowledge and attitude towards exclusive
Oddy, W. H. 2001. “Breastfeeding protects against
breastfeeding among 377 female students of School
illness and infection in infants and children: a
of Health Technology, Ilesha and to compare their
review of the evidence,” Breastfeed. Rev.,
responses with 60 primigravidae attending
vol. 9, no. 2, pp. 11–18.
antenatal clinic in Ile-Ife, Nigeria. The ages of the
Abstract: Nutrition is essential to the health and subjects ranged from 15 to 34 years. Data were
development of infants and children. Breastfeeding collected using pretested structured questionnaire.
is superior to infant formula feeding because in Approximately 47% of the total population were
addition to breastmilk’s nutritional advantages, it grouped under low level of knowledge of exclusive
protects against infections through specific and breastfeeding. There was no significant relationship
non-specific immune factors and has long-term in terms of knowledge between the two groups.
consequences for metabolism and disease later in There was, however, a significant relationship
life. The objectives of this paper are to summarize between the age of subjects and increased level of
the epidemiological and other scientific evidence in knowledge about EBF. Seventy percent of the
support of breastfeeding, to clarify why breastmilk primigravidae were graded as having poor attitudes
is a better food for infants than infant formula and as compared with 18% of the female students.
to demonstrate support for further breastfeeding About 42% of the total population would give
initiatives in Australia. There is much water and glucose D water to neonates within
epidemiological evidence for the benefits of 72 hours after delivery. These findings further
breastfeeding to the human infant against a wide suggest that planners of the Baby Friendly Initiative
range of illnesses and infections. Other scientific need to focus more on adolescents and the
181
longer than women with moderately traditional studies that assessed OL and/or LS-II [based on
gender role attitudes. Mother’s attitude toward test-weighing milk volume (MV) and/or breastmilk
breastfeeding, help with household tasks, and the biomarkers (BMB)] were identified. OL is a clearly
attitudes of friends and relatives toward defined and easily identified event across cultures,
breastfeeding were also very significantly related with the overwhelming majority of women being
to intended breastfeeding duration. Women who able to report when they experience it. Mean OL
did not work outside the home intended to ranges from 50 hours to 73 hours postpartum
breastfeed significantly longer than those who across studies and from 1 hour to 148 hours
were employed. postpartum within studies. The wide range
detected within samples is fully consistent with the
wide within sample LS-II variability as determined
Parrilla Rodriguez, A. M., T. R. Davila, J. J. by BMB or MV. Studies have identified similar risk
Gorrin Peralta, and A. A. Alonso. 2001. factors for delayed LS-II, such as labor and delivery
“Puerto Rican health teachers: attitudes stress, primiparity and insulin-dependent diabetes
towards breastfeeding,” P. R. Health Sci. J., mellitus, regardless of marker used (i.e., OL, MV
vol. 20, no. 1, pp. 57–61. or BMB). The correlation between OL and MV
Abstract: OBJECTIVE: The purpose of the study (r=–0.60) is of similar magnitude to that between
was to identify attitudes towards breastfeeding and OL and BMB (r=0.50) and that between BMB and
support for breastfeeding in public in a group of MV (r=0.47–0.69). In conclusion, OL is a valid
health teachers in the Department of Education. clinical indicator of LS-II. This has public health
METHOD: The study design was correlational relevance because studies have identified delayed
descriptive. A self-administered questionnaire was OL (i.e., >72 hours postpartum) as a risk factor for
used (Cronbach’s alpha=0.83) for 125 health shorter breastfeeding duration and for greater
teachers. Descriptive and inferential statistics (chi- infant weight loss by day 3 postpartum.
square and t-test) were used for data analysis. Multidisciplinary studies are needed to standardize
RESULTS: 89.6% were women, 47.1% were the definition of OL and to confirm its validity in
39 years of age or less, 76.4% were married, the different sociocultural contexts.
median of years in the profession was 12.5. Only
8.8% had breastfed exclusively, 46.1% used
Pinelli, J., S. A. Atkinson, and S. Saigal. 2001.
artificial feedings exclusively, and 45.1% combined
“Randomized trial of breastfeeding support in
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
182
NICU. MAIN OUTCOME MEASURE: Duration resources and for coordination of breastfeeding
of breastfeeding. RESULTS: At study entry, there care. Pediatricians have a pivotal role in achieving
were no statistically significant differences in major the goals of optimal breastfeeding and appropriate
demographic characteristics between groups. The infant growth.
mean duration of breastfeeding was 26.1 weeks
(SD=20.8; median, 17.4) in the SSBC group and
24.0 weeks (SD=20.5; median, 17.4) in the CHBS Ransjo-Arvidson, A. B., A. S. Matthiesen, G. Lilja,
group (not statistically significant). E. Nissen, A. M. Widstrom, and K. Uvnas-
CONCLUSIONS: Long-term breastfeeding Moberg. 2001. “Maternal analgesia during
counseling of parents of very low birthweight labor disturbs newborn behavior: effects on
infants in this study did not demonstrate a breastfeeding, temperature, and crying,” Birth,
significant difference in duration of breastfeeding. vol. 28, no. 1, pp. 5–12.
These results may be explained by the high Abstract: BACKGROUND: Newborns not exposed
motivation to breastfeed in both groups, a to analgesia, when placed on the mother’s chest,
relatively advantaged population, and the exhibit an inborn prefeeding behavior. This study
availability of community breastfeeding resources, was performed to assess the effects of different
which may have diminished any significant types of analgesia during labor on the development
differences that could have resulted from a of spontaneous breastfeeding movements, crying
breastfeeding intervention. The results of this study, behavior, and skin temperature during the first
compared with previous studies of very low hours of life in healthy term newborns.
birthweight infants, indicate a new trend to longer METHODS: Video recordings were made of
duration of breastfeeding in preterm infants. 28 newborns who had been dried and placed in
skin-to-skin contact between their mother’s breasts
immediately after delivery. The video recordings
Powers, N. G. 2001. “How to assess slow growth
were analyzed blindly with respect to infant
in the breastfed infant. Birth to 3 months,”
exposure to analgesia. Defined infant behaviors
Pediatr. Clin. North Am., vol. 48, no. 2,
were assessed every 30 seconds. Group one
pp. 345–363.
mothers (n=10) had received no analgesia during
Abstract: Pediatricians must monitor early labor, group two mothers (n=6) had received
breastfeeding to detect and manage breastfeeding mepivacaine via pudendal block, and group three
difficulties that lead to slow weight gain and mothers (n=12) had received pethidine or
subsequent low milk production. Infant growth bupivacaine or more than one type of analgesia
during the first three months of life provides a clear during labor. RESULTS: All infants made finger
indication of breastfeeding progress. Healthy, and hand movements, but the infant’s massagelike
breastfed infants lose less than 10% of birthweight hand movements were less frequent in infants
and return to birthweight by age two weeks. They whose mothers had received labor analgesia. A
then gain weight steadily, at a minimum of 20g per significantly lower proportion of group three
day, from age two weeks to three months. Any infants made hand-to-mouth movements
183
Rao, M. R., M. L. Hediger, R. J. Levine, A. B. birth. SEARCH STRATEGY: We searched the
Naficy, and T. Vik. 2002. “Effect of Cochrane Pregnancy and Childbirth Group trials
breastfeeding on cognitive development of register. SELECTION CRITERIA: randomized and
infants born small for gestational age,” Acta quasi-randomized trials comparing on demand or
Paediatr., vol. 91, no. 3, pp. 267–274. frequent breastfeeding (two or three hourly)
schedules in hospital compared with four hourly
Abstract: Breastfeeding during infancy appears to
restricted feeds. DATA COLLECTION AND
result in enhanced cognitive development during
ANALYSIS: Trial quality was assessed and data
childhood, but it is not known whether
were extracted independently by two reviewers.
breastfeeding should be encouraged for infants
MAIN RESULTS: Three trials involving 400
born small for gestational age (SGA) whose growth
women were included. There were significant
might otherwise benefit from nutritional
methodological limitations in some of the studies.
supplementation. To address this issue, duration of
Compared to two hourly, three hourly or on
exclusive breastfeeding and cognitive development
demand breastfeeding, restricted (less frequent four
were evaluated prospectively for 220 term children
hourly breastfeeding) was associated with greater
born SGA and 299 term children born appropriate
discontinuation of breastfeeding by four to six
for gestational age (AGA). Cognitive development
weeks postpartum (relative risk=1.53,
was assessed using the Bayley Scale of Infant
95% confidence interval: 1.08 to 2.15). Restricted
Development at 13 months and Wechsler Preschool
breastfeeding was associated with increased
and Primary Scales of Intelligence at five years of
incidence of sore nipples (relative risk=2.12,
age. Infants born SGA were given supplemental
95% confidence interval: 1.22 to 3.68),
foods significantly earlier than those born AGA.
engorgement (relative risk=2.10, 95% confidence
Growth of infants born SGA was not related to
interval: 1.25 to 3.21) and the need to give
early nutritional supplementation. The salutary
additional (formula) feeds (relative risk=3.14,
effect of exclusive breastfeeding on cognitive
95% CI: 1.24 to 8.00). REVIEWER’S
development was greater for children born SGA
CONCLUSIONS: There appear to be a number of
than for those born AGA. Based on a linear
disadvantages from restricting breastfeeding to a
association between duration of exclusive
four hourly schedule in the first few days after
breastfeeding and intelligence quotient (IQ),
birth. More frequent or on demand breastfeeding is
children born SGA and exclusively breastfed for
associated with fewer complications and longer
24 weeks were predicted to have an 11-point IQ
duration of breastfeeding.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
184
are in school. In these infants, small improvements Western Australia and 503 women from the
in IQ and neurologic function could have a much Darling Downs area, Queensland, Australia.
greater effect. Further study of neurodevelopmental RESULTS: Breastfeeding at discharge was most
outcome in premature infants fed breastmilk strongly associated with perceived paternal support
compared with those fed preterm formula are of breastfeeding with an adjusted odds ratio of
indicated. This information should not change the 9.13 (95% CI: 4.83–17.26), using multivariate
practice of encouraging breastfeeding of term and logistic regression analysis. Duration of
preterm infants because other advantages to breastfeeding was most strongly associated with
breastfeeding exist. the length of time a mother intended to breastfeed
with an adjusted relative risk of 4.18 (95% CI:
2.81–6.22) for > or = four months relative to
Ross, J. S. and P. W. Harvey. 2003. “Contribution <4 months. CONCLUSIONS: Interventions which
of breastfeeding to vitamin A nutrition of aim to increase the length of time a woman intends
infants: a simulation model,” Bull. World to breastfeed, and which highlight the role of the
Health Organ., vol. 81, no. 2, pp. 80–86. father in successful breastfeeding, are
Abstract: OBJECTIVE: To provide information on recommended to help achieve recommended targets
the potential contribution to vitamin A nutrition in for breastfeeding initiation and duration.
infants of strategies for improving maternal vitamin
A status and increasing the consumption of
Semba, R. D. and F. Delange. 2001. “Iodine in
breastmilk. METHODS: The contribution of
human milk: perspectives for infant health,”
breastfeeding to the vitamin A nutrition of children
Nutr. Rev., vol. 59, no. 8 Pt 1, pp. 269–278.
in eight age groups between 0 and 24 months was
simulated under four sets of conditions involving Abstract: Iodine is essential for normal growth,
two levels of breastmilk consumption with or mental development, and survival of infants. The
without maternal vitamin A supplementation. main source of iodine for breastfeeding infants is
FINDINGS: During the first six months, optimal the iodine found in human milk. Despite the
breastfeeding on its own (compared with importance of iodine for infant health, there have
withholding colostrum and then partially been limited studies addressing human milk iodine
breastfeeding after the first week) was as effective as concentrations. The newly recommended Adequate
postpartum maternal supplementation alone, retinol Intake of iodine for infants is 110 microg/day for
intakes being increased by 59 micrograms per day infants zero to six months and 130 microg/day for
and 68 micrograms per day, respectively. Combined infants seven to twelve months. Further studies of
in synergy, these strategies increase retinol intake by human milk iodine are needed to ensure that iodine
144 micrograms per day, or 36% of the prophylaxis is providing sufficient iodine for
recommended intake. After six months, partial mothers and infants worldwide.
breastfeeding continued to provide a significant
proportion of the recommended intakes: 42% from
6 to 12 months and 61% during the second year. Sikorski, J., M. J. Renfrew, S. Pindoria, and A.
Wade. 2002. “Support for breastfeeding
185
2001. Secondary references were searched and Singhal, A., T. J. Cole, and A. Lucas. 2001. “Early
researchers in the field were contacted. nutrition in preterm infants and later blood
SELECTION CRITERIA: Controlled trials of pressure: two cohorts after randomized trials,”
acceptable quality comparing extra support for Lancet, vol. 357, no. 9254, pp. 413–419.
breastfeeding mothers with usual maternity care.
Abstract: BACKGROUND: Despite data relating
DATA COLLECTION AND ANALYSIS: Data
body size in early life to later cardiovascular
were extracted by one reviewer and checked by a
outcomes, the hypothesis that nutrition affects such
second reviewer. MAIN RESULTS: Twenty eligible
outcomes has not been established. Breastfeeding
randomized or quasi-randomized controlled trials
has been associated with lower blood pressure in
from 10 countries were identified involving 23,712
later life, but previous studies have not controlled
mother-infant pairs. There was a beneficial effect
for possible confounding factors by using a
on the duration of any breastfeeding in the meta-
randomized design with prospective follow-up. We
analysis of all forms of extra support (relative risk
undertook such a study to test the hypothesis that
(RR) for stopping any breastfeeding before six
early diet programs blood pressure in later life in
months 0.88 [95% confidence interval (CI): 0.81,
children randomly assigned different diets at birth.
0.95]; 15 trials, 21,910 women). The effect was
METHODS: Blood pressure was measured at age
greater for exclusive breastfeeding (RR=0.78 [95%
13–16 years in 216 (23%) of a cohort of
CI: 0.69, 0.89]; 11 trials, 20,788 women). Extra
926 children who were born prematurely and had
professional support appeared beneficial for any
participated at birth in two parallel randomized
breastfeeding (RR=0.89 [95% CI: 0.81, 0.97]; 10
trials in five neonatal units in the UK. Dietary
trials, 19,696 women) and for exclusive
interventions were: donated banked breastmilk
breastfeeding (RR=0.90 [95% CI: 0.81, 1.01]; six
versus preterm formula and standard term formula
trials, 18,258 women) although the latter effect did
versus preterm formula. FINDINGS: Children
not achieve full statistical significance. Lay support
followed up at age 13–16 years were similar to
was effective in reducing the cessation of exclusive
those not followed up in terms of social class and
breastfeeding (RR=0.66 [95% CI: 0.49, 0.89]; five
anthropometry at birth. Mean arterial blood
trials, 2,530 women) but its effect on any
pressure at age 13–16 years was lower in the 66
breastfeeding did not reach statistical significance
children assigned banked breastmilk (alone or in
(RR=0.84 [95% CI: 0.69, 1.02]; five trials, 2,224
addition to mother’s milk) than in the 64 assigned
women). Professional support in the largest trial to
preterm formula (mean 81.9 [SD 7.8] vs. 86.1 [6.5]
assess health outcomes produced a significant
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
186
following birth. When possible, the infant should CONCLUSIONS: Cabbage leaves and gel packs
be allowed to root and latch on spontaneously were equally effective in the treatment of
within the first hour of life. Many common nursery engorgement. Since both cabbage extract and
routines such as weighing the infant, placebo cream were equally effective, the
administration of vitamin K and application of alleviation in symptoms may be brought about by
ocular antibiotics can be safely delayed until after other factors, such as breast massage. Ultrasound
the initial breastfeeding. Postpartum care practices treatment is equally effective with or without the
that improve breastfeeding rates include rooming- ultra-wave emitting crystal, therefore its
in, anticipatory guidance about breastfeeding effectiveness is more likely to be due to the effect
problems and the avoidance of formula of radiant heat or massage. Pharmacologically,
supplementation and pacifiers. oxytocin was not an effective engorgement
treatment while Danzen and bromelain/trypsin
complex significantly improved the symptoms of
Snowden, H. M., M. J. Renfrew, and M. W. engorgement. Initial prevention of breast
Woolridge. 2001. “Treatments for breast engorgement should remain the key priority.
engorgement during lactation,” Cochrane.
Database. Syst. Rev., no. 2, p. CD000046.
Srivastava, S. P., V. K. Sharma, and S. P. Jha. 1994.
Abstract: BACKGROUND: National surveys have
“Mortality patterns in breast versus artificially
shown that painful breasts are the second most
fed term babies in early infancy: a longitudinal
common reason for giving up breastfeeding in the
study,” Indian Pediatr., vol. 31, no. 11,
first two weeks after birth in the UK. One factor
pp. 1393–1396.
contributing to such pain can be breast
engorgement. Views differ as to how engorgement Abstract: In this study 500 full-term breastfed and
arises, although restrictive feeding patterns in 500 full-term top-fed babies were divided into two
hospital are likely to have contributed in the past. groups of weight >2.5kg and < or = 2.5kg each,
These differing views are reflected in the range of and were followed up for the mortality pattern.
solutions offered to treat engorgement in Eight hundred of these completed the full follow-
breastfeeding mothers and these treatments are up period of six months. Neonatal mortality in
assessed in this review. OBJECTIVES: To determine term babies in the present study was 40 per 1,000
the effects of any proposed intervention to relieve and mortality during 1–6 months period was 55
symptoms of breast engorgement among per 1,000. Early neonatal mortality in breastfed
breastfeeding women. SEARCH STRATEGY: The >2.5kg was 0.55% against 7.8% in < or = 2.5kg
register of clinical trials maintained and updated by breastfed babies. The corresponding figures in
the Cochrane Pregnancy and Childbirth Group. artificially fed was 1.17% and 9.37%, respectively.
CINAHL and MEDLINE were also searched. Date Late neonatal mortality in breastfed >2.5kg was
of last search: December 2000. SELECTION zero and in < or = 2.5kg was 2.14%. These values
CRITERIA: All randomized and ‘quasi- in artificially fed were zero and 3.12%,
randomized’ controlled trials, with or without respectively. Mortality in one to six months period
187
breastfeeding practices as part of health care seemed to be equally hazardous. For deaths due to
planning, a study was carried out to describe diarrhea the increased risk associated with not
breastfeeding and to identify weaning-related breastfeeding was greatest in the first two months
factors. METHODS: Of all municipalities in the of life (RR for completely weaned vs. breastfed
State of Sao Paulo, Brazil, openly called to without supplementary milk=23.3).
participate in the study, 84 joined in. Personnel
underwent training to collect data during the
national mass immunization day in 1998. A sample Vogel, A. M., B. L. Hutchison, and E. A. Mitchell.
strategy, proportional to the infant population, was 2001. “The impact of pacifier use on
developed for each participant. Standardized breastfeeding: a prospective cohort study,” J.
questionnaires were applied to assess infant feeding Paediatr. Child Health, vol. 37, no. 1,
practices in the previous 24 hours. Descriptive pp. 58–63.
statistic analysis on breastfeeding prevalence and Abstract: OBJECTIVES: To determine the
logistic regression analysis of risk factors for predictors of pacifier use during the first year of
discontinuing exclusive breastfeeding of infants life and to assess the influence of pacifier use on
aged less than four months and weaning of infants the duration of breastfeeding. METHODOLOGY:
aged less than a year were performed. RESULTS: A prospective cohort study was conducted. Three
Exclusive breastfeeding rates in the first four hundred and fifty mother-infant pairs were
months of life were under 30%. The risk factors followed to one year of age to determine the
were: lower maternal education status; lack of impact of the use of a pacifier on the duration of
access to the so-called “Baby Friendly Hospital breastfeeding. RESULTS: A cohort of 441 mothers
Initiative”; primiparity; and early age pregnancy. were enrolled and 79% participated. Ninety-four
Around 50% of children under a year old were percent were followed up to one year. Daily
breastfed. CONCLUSIONS: Lacks of access to the pacifier use was associated with early cessation of
“Baby Friendly Hospital Initiative,” primiparity, breastfeeding (risk ratio (RR) 1.71; 95%
and mother’s unemployment or engagement in an confidence interval 95% (CI): 1.29, 2.28) and a
informal occupation activity were risk factors for reduced duration of full breastfeeding (adjusted
weaning. Local breastfeeding rates are extremely (adj.) RR=1.35; 95% CI: 1.05, 1.74). Finger
variable in the State of Sao Paulo, reinforcing the sucking was not associated with a reduced duration
importance of local, swift, and easily feasible of breastfeeding (RR=1.05; 95% CI: 0.81, 1.37).
health care actions.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
188
help those concerned with improving maternity Abstract: BACKGROUND: The debate on
services to concretely evaluate how they are helping breastfeeding in areas of high HIV prevalence has
or hindering breastfeeding and whether they are led to the development of simulation models that
encouraging and supporting mothers in every attempt to assess the risks and benefits associated
possible way. The organizations stress that with breastfeeding. An essential element of these
breastfeeding is an unequaled way of providing simulations is the extent to which breastfeeding
ideal food for the healthy growth and development protects against infant and child mortality;
of infants, and that it has an unique biological and however, few studies are available on this topic. We
emotional influence upon the health of mothers did a pooled analysis of studies that assessed the
and children. Breastmilk helps protect infants effect of not breastfeeding on the risk of death due
against disease, while breastfeeding helps space to infectious diseases. METHODS: Studies were
child births. The prevalence and duration of identified through consultations with experts in
breastfeeding, however, have declined in many international health, and from a MEDLINE search
parts of the world for a variety of social, economic, for 1980–1998. Using meta-analytical techniques,
and cultural reasons. The WHO and UNICEF we assessed the protective effect of breastfeeding
recommend that professional and other workers in according to the age and sex of the infant, the
health care facilities make every effort to protect, cause of death, and the educational status of the
promote, and support breastfeeding, and to mother. FINDINGS: We identified eight studies,
provide expectant and new mothers with objective data from six of which were available (from Brazil,
and consistent advice in that regard. This short The Gambia, Ghana, Pakistan, the Philippines, and
paper discusses preparing health workers to Senegal). These studies provided information on
promote and support breastfeeding, and training 1,223 deaths of children under two years of age. In
health workers. the African studies, virtually all babies were
breastfed well into the second year of life, making
Available at:
it impossible to include them in the analyses of
WHO
infant mortality. On the basis of the other three
bookorders@who.ch
studies, protection provided by breastmilk declined
publications@who.ch
steadily with age during infancy (pooled odds
ratios: 5.8 [95% CI: 3.4–9.8] for infants <2
Wight, N. E. 2001. “Management of common months of age, 4.1 [2.7–6.4] for 2–3-month-olds,
breastfeeding issues,” Pediatr. Clin. North Am., 2.6 [1.6–3.9] for 4–5-month-olds, 1.8 [1.2–2.8] for
vol. 48, no. 2, pp. 321–344. 6–8-month-olds, and 1.4 [0.8–2.6] for nine to
eleven month olds). In the first six months of life,
Abstract: Breastfeeding provides ideal nutrition, protection against diarrhea was substantially
growth hormones, and antibodies that change over greater (odds ratio 6.1 [4.1–9.0]) than against
time as growing infants’ and children’s needs deaths due to acute respiratory infections (2.4
change and provides these inexpensively, with no [1.6–3.5]). However, for infants aged six to eleven
harm to the environment. Breastfed infants are months, similar levels of protection were observed
healthier than other infants overall, and research (1.9 [1.2–3.1] and 2.5 [1.4–4.6], respectively). For
190
Low Birthweight and Prematurity
Ahmed, F. U., E. Karim, and S. N. Bhuiyan. 2000. birthweight (p<0.001). Intercurrent diarrhea,
“Mid-arm circumference at birth as predictor of aspiration pneumonia, and septicemia did not
low birthweight and neonatal mortality,” J. differ. Training mothers to nurse their low
Biosoc. Sci., vol. 32, no. 4, pp. 487–493. birthweight babies can significantly reduce
mortality rates and decrease workload on nurses.
Abstract: In Bangladesh, like other developing
Policy formulation using this approach can save
countries, most births occur at home or in the
costs in developing countries.
community, so logistic problems and taboos
prevent the weighing of every newborn child. This
study was performed to see whether other simpler Ashworth, A. 1998. “Effects of intrauterine growth
measurements could be substituted for weight to retardation on mortality and morbidity in
identify neonates of low birthweight. A total of infants and young children,” Eur. J. Clin. Nutr.,
1,676 live births at the Chittagong Medical College vol. 52 Suppl 1, pp. S34–S41.
Hospital constituted the study sample, and this
showed a high correlation between mid-arm Abstract: This review aims to quantify the risks of
circumference and birthweight (r=0.792, p<0.000). mortality and morbidity associated with
A mid-arm circumference of <9.0cm had the best intrauterine growth retardation (IUGR). Twenty-
sensitivity and specificity for identifying newborns nine data sets with birthweight-specific mortalities
with a birthweight of less than 2,500g. These are examined to determine whether consistent
neonates were followed up to record neonatal patterns of risk emerge when data from different
deaths. Neonatal mortality showed an inverse populations are compared. Measures of mortality
relation with mid-arm circumference. A mid-arm risk are also made with birthweight as a
circumference of <9.0cm and a birthweight of dichotomous variable. Twelve data sets are
<2,500g were equally useful in predicting neonatal presented. From the data available, it is estimated
outcome. Mid-arm circumference is a simple, quick that for term infants weighing 2,000g–2,499g at
and reliable indicator for predicting low birth, the risk of neonatal death is four times
birthweight and neonatal outcome, and can be higher than for infants weighing 2,500g–2,999g,
easily measured by medical practitioners and and 10 times higher than for infants weighing
traditional birth attendants (TBAs) in the 3,000g–3,499g. The risk of postneonatal death in
community of developing countries like term infants weighing 2,000g–2,499g is estimated
Bangladesh. to be two times higher than for infants
2,500g–2,999g, and four times that of infants
weighing 3,000g–3,499g. Estimates of risk for
Arif, M. A. and K. Arif. 1999. “Low birthweight IUGR infants are less consistent than for preterm
babies in the Third World: maternal nursing infants. This could be due to methodological
versus professional nursing care,” J. Trop. differences, particularly smaller sample sizes in the
191
inclusion of infants with congenital anomalies who lifestyle and a genetically determined susceptibility.
are often stunted. Wasted infants are more prone Recent research, however, suggests that growth in
than stunted infants to neonatal morbidity. No utero may also play an important role.
comparative postneonatal data were located.
Barker, D. J., C. N. Martyn, C. Osmond, C. N.
Ashworth, A., S. S. Morris, P. I. Lira, and S. M. Hales, and C. H. Fall. 1993. “Growth in utero
Grantham-McGregor. 1998. “Zinc and serum cholesterol concentrations in adult
supplementation, mental development and life,” BMJ, vol. 307, no. 6918, pp. 1524–1527.
behaviour in low birthweight term infants in
Abstract: OBJECTIVE: To see whether reduced
northeast Brazil,” Eur. J. Clin. Nutr., vol. 52,
rates of fetal growth are related to raised serum
no. 3, pp. 223–227.
cholesterol concentrations in adult life. DESIGN:
Abstract: OBJECTIVE: To test whether zinc Follow-up study of men and women whose size at
supplementation reduces the deficits in mental birth had been recorded. SETTING: Jessop and
development and behaviour that are found in term Northern General Hospitals, Sheffield. SUBJECTS:
infants of low birthweight in the study population. 219 men and women born in the Jessop Hospital
DESIGN: A prospective double-blind, part- during 1939–1940. MAIN OUTCOME
randomized efficacy trial. SETTING: A low- MEASURES: Serum concentrations of total
income population in Pernambuco, northeast cholesterol, low density lipoprotein cholesterol, and
Brazil, where the economy is largely dependent on apolipoprotein B. RESULTS: Men and women who
sugar-cane production, and where over 90% of had had a small abdominal circumference at birth
deliveries occur in health facilities. SUBJECTS: had raised serum concentrations of total and low
During a 20-month period, all singleton, term density lipoprotein cholesterol and apolipoprotein
infants weighing 1,500g–2,499g born to families B. This was independent of the duration of
of low income (<U.S. $280/month) were enrolled gestation. Serum concentrations of total cholesterol
at birth (n=205). At 6 and 12 months, the fell by 0.25 mmol/l (95% confidence interval: 0.09
numbers tested were 163 and 138, respectively. to 0.42) with each 1in (2.54cm) increase in
INTERVENTION: Infants born from January abdominal circumference. The corresponding figure
1993–January 1994 were randomly assigned to for serum low density lipoprotein cholesterol was
receive daily, except Sundays, a placebo (n=66) or 0.26 mmol/l (0.11 to 0.42) and for serum
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
1mg zinc (n=68). Those born February–August apolipoprotein B 0.04g/l (0.02 to 0.07). Small head
1994 were given 5mg zinc (n=71). and chest circumferences at birth and short length
Supplementation was for eight weeks, starting at were each associated with raised serum low density
birth. Field workers visited each infant at home to lipoprotein cholesterol concentrations but the
administer the supplement. RESULTS: At 6 and trends disappeared in a simultaneous regression
12 months, mental and psychomotor development with abdominal circumference at birth. The
was assessed with the Bayley Scales of Infant association between abdominal circumference at
Development and no significant differences in the birth and low density lipoprotein cholesterol
scores of the three groups were found. At concentration was independent of social class,
12 months, behaviour was also assessed on five current body weight, cigarette smoking, and
ratings. Ratings were highest in infants given 5mg alcohol consumption. CONCLUSION: Raised
zinc (P=0.042). CONCLUSIONS: Zinc serum cholesterol concentrations in adult life are
supplementation (5mg/day) for eight weeks may associated with impaired growth during late
reverse some of the poor behaviors, particularly gestation, when fetal undernutrition has a
responsiveness, exhibited by low birthweight disproportionate effect on liver growth. Impaired
infants. No amelioration of their mental and liver growth may permanently alter low density
psychomotor deficits was found. lipoprotein cholesterol metabolism.
192
Abstract: A cohort of 5,914 liveborns (99% of the and birthweight, but the correlation was maximum
city births) was followed up to the age of four for chest circumference (r=0.8696) and mid-arm
years in Pelotas, southern Brazil. Besides the circumference (r=0.8110). A mid-arm
perinatal evaluation, the cohort children were circumference of less than or equal to 8.7cm and a
examined again at mean ages of 11, 23, and 47 chest circumference of less than or equal to
months. During each visit the children were 30cm had the best sensitivity and specificity for
weighed and measured and information on identifying neonates with a birthweight of
morbidity was collected. Also, multiple sources of 2,500g or less. Measurements on 501 consecutive
information were used for monitoring mortality live births in the community were recorded and the
throughout the study. Of the babies with known infants followed up at specified ages. Mid-arm
gestational age, 9.0% were classified as circumference was again significantly correlated to
intrauterine growth-retarded and 6.3% as preterm. birthweight (r=0.6918). Neonatal mortality showed
Excluding those of unknown gestational age, an inverse relation but postneonatal mortality an
62% of low birthweight babies were intrauterine inconsistent relation with mid-arm circumference.
growth-retarded and 36% were preterm. A mid-arm circumference of less than or equal to
Intrauterine growth retardation was statistically 8.7cm and a birthweight of less than or equal to
associated with maternal height, prepregnancy 2,500g were equally useful in predicting neonatal
weight, birth interval, and smoking, whereas outcome. Mid-arm and chest circumferences are
preterm births were associated with maternal simple, practicable, quick, and reliable indicators
prepregnancy weight and maternal age. Preterm for predicting low birthweight and neonatal
babies had a perinatal mortality rate 13 times outcome in the community and can be easily
higher than that of babies of appropriate measured by paramedical workers in developing
birthweight and gestational age and two times nations.
higher than that of intrauterine growth-retarded
babies. Infant mortality rates presented a similar
pattern, with the differentials being more Cohen, R. J., K. H. Brown, L. L. Rivera, and K. G.
pronounced during the neonatal than in the Dewey. 2000. “Exclusively breastfed, low
postneonatal period. In the first two years of life birthweight term infants do not need
intrauterine growth-retarded children were at supplemental water,” Acta Paediatr., vol. 89,
almost twice the risk of being hospitalized for no. 5, pp. 550–552.
diarrhea compared with appropriate birthweight, Abstract: Breastmilk intake, urine volume and
term children, while preterm children experienced urine-specific gravity (USG) of exclusively breastfed,
only a slightly greater risk. For pneumonia, low birthweight (LBW) term male infants in
however, both groups of children were hospitalized Honduras were measured during eight-hour periods
significantly more than appropriate birthweight, at two (n=59) and eight (n=68) weeks of age.
term children. In terms of growth, despite their Ambient temperature was 22°C–36°C and relative
earlier disadvantage, preterm children gradually humidity was 37%–86%. Maximum USG ranged
caught up with their appropriate birthweight, term from 1.001 to 1.012, all within normal limits.
counterparts. CONCLUSIONS: We conclude that supplemental
water is not required for exclusively breastfed, LBW
193
affects 16.4% of all newborns, or about Fattal-Valevski, A., Y. Leitner, M. Kutai, E. Tal-
20.5 million infants each year. IUGR defined as Posener, A. Tomer, D. Lieberman, A. Jaffa, A.
birthweight below the 10th percentile of the Many, and S. Harel. 1999.
birthweight-for-gestational-age reference curve, “Neurodevelopmental outcome in children with
represents 23.8%, or approximately 30 million intrauterine growth retardation: a 3-year
newborns per year. Overall, nearly 75% of all follow-up,” J. Child Neurol., vol. 14, no. 11,
affected newborns are born in Asia—mainly in pp. 724–727.
South-central Asia—20% in Africa, and about
Abstract: The study was designed to detect early
5% in Latin America. Although some of these are
clinical predictors of developmental outcome in
healthy, small infants who merely represent the
children with intrauterine growth retardation.
lower tail of a fetal growth distribution, in most
Eighty-five children with intrauterine growth
developing countries a large proportion of
retardation were followed up prospectively to
newborns suffer from some degree of intrauterine
three years of age, using biometric parameters,
growth retardation. These data demonstrate that
perinatal risk questionnaires, and
many developing countries currently exceed the
neurodevelopmental evaluations. Forty-two
internationally recommended IUGR (>20%) and
children served as controls. A significant
LBW (>15%) cut-off levels for triggering public
difference in neurodevelopmental score at three
health action, and that population-wide
years of age was noted between the intrauterine
interventions aimed at preventing fetal growth
growth retardation and control groups (P<.001).
retardation are urgently required.
In the intrauterine growth retardation group, the
clinical parameters that most significantly
De Vaquera, M. V., J. W. Townsend, J. J. Arroyo, correlated with outcome were cephalization index
and A. Lechtig. 1983. “The relationship (head circumference: birthweight ratio), neonatal
between arm circumference at birth and early risk score, and birthweight. The best predictor of
mortality,” J. Trop. Pediatr., vol. 29, no. 3, pp. three-year outcome was the cephalization index
167–174. (P<.01). The children with intrauterine growth
retardation with neonatal complications had
Abstract: Previous reports have shown that significantly lower IQ scores (P<.05) and a poorer
birthweight is associated with mortality rate during neurodevelopmental outcome (P<.01) than those
the neonatal and postnatal periods and that low without complications. Children with intrauterine
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
arm circumference at birth (LACB: = or <9.0cm) is growth retardation are at higher risk for
closely correlated with birthweight. This paper developmental disabilities than are controls,
explores the relationship between arm especially in the presence of neonatal
circumference at birth and early mortality. Eight complications and a high cephalization index.
hundred and twenty-three newborns in Guatemala
were studied, of which 416 had a normal arm
circumference and 407 were LACB. In addition to Feldman, R. and A. I. Eidelman. 1998.
arm circumference, weight, height, chest and head “Intervention programs for premature infants.
circumferences were measured during the first How and do they affect development?,” Clin.
24 hours after birth. Both groups were followed up Perinatol., vol. 25, no. 3, pp. 613–626, ix.
during 14 days. All of the 27 deaths observed in
Abstract: Over the past 30 years, a variety of
the study infants occurred in the LACB group
intervention programs for the enhancement of the
(p>0.001). Relative risk of death during this period
neurodevelopmental status of premature infants
was 10 to 17 times higher in the LACB group than
have been implemented with confusing outcomes.
in the low risk group. Estimated sensitivity and
In addition, diametrically different forms of
specificity of LACB were 100% and 84%
therapy that rest on contrasting theories have led,
respectively. These results indicate that LACB is a
paradoxically, to similar results. This article
useful indicator to predict risk of death during the
systematically examines and analyses the various
first 14 days of life in areas where birthweight
modes of therapy and their underlying theoretical
assessment is not feasible.
mechanisms. Skin-to-skin contact (kangaroo care)
is suggested as the intervention that most logically
194
meshes the premature infant’s need to develop state Abstract: OBJECTIVES: (1) To compare the
regulation while facilitating sequential sensory mental and psychomotor development of low
development and promoting mother-infant birthweight term (LBW-T) infants with that of
attachment. appropriate birthweight (ABW) infants at six and
12 months of age. (2) To examine the relationship
between developmental levels and social
Fewtrell, M. S., R. Morley, R. A. Abbott, A. background. METHODS: A cohort of 131 LBW-T
Singhal, T. Stephenson, U. M. MacFadyen, H. infants (1,500g to 2,499g) and 131 ABW infants
Clements, and A. Lucas. 2001. “Catch-up (3,000g to 3,499g) matched for sex and time of
growth in small-for-gestational-age term infants: birth, recruited from six maternity centers in
a randomized trial,” Am. J. Clin. Nutr., vol. 74, Northeast Brazil were followed for one year. Their
no. 4, pp. 516–523. development was assessed with the Bayley Scales
Abstract: BACKGROUND: Small-for-gestational- at six and 12 months of age, and at 12 months
age (SGA) term infants are at risk of long-term their behavior during the test was rated on five
growth deficits. OBJECTIVE: The objectives were scales. Details of their families’ socioeconomic
to test the hypothesis that postnatal growth in SGA status were recorded and the degree of stimulation
term infants can be altered by dietary intervention in their homes was assessed. RESULTS: At six
and to examine whether there is a critical window months of age the LBW-T infants had significantly
for nutritional programming of the growth lower scores than the ABW infants on the mental
trajectory during the first nine months postnatally. development index (MDI; 4.2 points lower,
DESIGN: Healthy term (gestation > or = 37 weeks) p<0.001) and on the psychomotor development
infants with birthweights below the 10th centile index (PDI; 7.3 points lower, p<0.001). The
were randomly assigned to receive standard term difference had increased by 12 months of age
formula (TF; n=147) or nutrient-enriched formula (MDI 7.0 points lower, p<0.001; PDI 9.9 points
(EF; n=152) for the first nine months; lower, p<0.001). Socioeconomic variables were
175 breastfed SGA term infants formed a reference related to development at both ages in both
group. The main outcome measures were weight, groups. Maternal literacy was significantly related
length, and occipitofrontal head circumference to the PDI in LBW-T infants at 12 months but not
(OFC) at nine and 18 months. RESULTS: The in ABW infants. Similarly, stimulation in the home
infants fed the EF showed greater gains in length was related to the MDI in LBW-T infants at six
by nine (1.1cm; 95% CI: 0.38, 1.79) and 18 and twelve months but not in ABW infants. LBW-
(1.0cm; 0.25, 1.83) months and in OFC by nine T infants were less active, cooperative, vocal, and
(0.5cm; 0.1, 0.9) and 18 (0.6cm; 0.2, 1.1) months happy, and were more inhibited than ABW infants.
than did infants fed the TF; the differences were CONCLUSIONS: LBW-T infants had poorer
larger in females. The dietary effects were development than ABW infants and differed in
independent of the pattern of growth retardation. their behavior. There was an interaction between
breastfed infants showed greater gains in weight birthweight and the environment. LBW-T infants,
and OFC by 18 months than did infants fed the but not ABW infants, were affected by the quality
TF; however, these differences disappeared after of stimulation in the home and maternal illiteracy.
adjustment for age, parental size, and birth order.
195
mental and behavioral outcomes in adolescence Abstract: CONTEXT: The World Health
and adulthood. Organization defines preterm birth as birth at less
than 37 completed gestational weeks, but most
studies have focused on very preterm infants (birth
Hales, C. N., Barker, D. J., Clark, P. M., Cox, L. at <32 weeks) because of their high risk of
J., Fall, C., Osmond, C., and Winter, P. D. mortality and serious morbidity. However, infants
1991. “Fetal and infant growth and impaired born at 32 through 36 weeks are more common
glucose tolerance at age 64,” BMJ, vol. 303, and their public health impact has not been well
no. 6809, pp. 1019–1022. studied. OBJECTIVE: To assess the quantitative
Abstract: OBJECTIVE: To discover whether contribution of mild (birth at 34–36 gestational
reduced fetal and infant growth is associated with weeks) and moderate (birth at 32–33 gestational
non-insulin dependent diabetes and impaired weeks) preterm birth to infant mortality. DESIGN,
glucose tolerance in adult life. DESIGN: Follow up SETTING, AND PARTICIPANTS: Population-
study of men born during 1920–1930 whose based cohort study using linked singleton live birth-
birthweights and weights at one year were known. infant death cohort files for U.S. birth cohorts for
SETTING: Hertfordshire, England. SUBJECTS: 468 1985 and 1995 and Canadian birth cohorts
men born in east Hertfordshire and still living there. (excluding Ontario) for 1985–1987 and
MAIN OUTCOME MEASURES: Fasting plasma 1992–1994. MAIN OUTCOME MEASURES:
glucose, insulin, proinsulin, and 32–33 split pro- Relative risks (RRs) and etiologic fractions (EFs) for
insulin concentrations and plasma glucose and overall and cause-specific early neonatal (age
insulin concentrations 30 and 120 minutes after a 0–6 days), late neonatal (age 7–27 days),
75g glucose drink. RESULTS: 93 men had impaired postneonatal (age 28–364 days), and total infant
glucose tolerance or hitherto undiagnosed diabetes. death among mild and moderate preterm births vs.
They had had a lower mean birthweight and a term births (at >/=37 gestational weeks). RESULTS:
lower weight at one year. The proportion of men Relative risks for infant death from all causes
with impaired glucose tolerance fell progressively among singletons born at 32 through 33 gestational
from 26% (6/23) among those who had weighted weeks were 6.6 (95% confidence interval [CI]:
18lb (8.16kg) or less at one year to 13% (3/24) 6.1–7.0) in the United States in 1995 and 15.2
among those who had weighed 27lb (12.25kg) or (95% CI: 13.2–17.5) in Canada in 1992–1994;
more. Corresponding figures for diabetes were 17% among singletons born at 34 through 36 gestational
weeks, the RRs were 2.9 (95% CI: 2.8–3.0) and 4.5
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
196
Kumar, A., M. Mohan, S. Ramji, P. U. Iyer, J. monitored up to six to seven years of age using
Marwah, and V. Kapani. 1987. “The bangle as biometric parameters, perinatal risk questionnaires,
a screening technique for identification of low and detailed neurodevelopmental and cognitive
birthweight neonates,” Indian J. Med. Res., assessments. Forty-one children served as age-
vol. 86, pp. 621–623. matched, appropriate for gestational age controls. A
significant difference in growth parameters (P<.001),
Abstract: Evaluation of a simple technique, using a
neurodevelopmental score (P<.05), and IQ (P<.05)
bangle to measure the midarm circumference at
was found between the children with intrauterine
birth, which has a strong correlation with both
growth retardation and controls. A specific profile
birthweight as well as neonatal outcome was
of difficulties in coordination, lateralization, spatial
undertaken. Appropriatel sized bangles (8.5cm and
and graphomotor skills, and abundance of
7.5cm) were passed up to the midarms of 1,412
associated movements is typical of the children with
newborns to determine their efficacy in detecting
intrauterine growth retardation and hints at possible
low birthweight. High sensitivity and specificity
later learning disabilities. The clinical parameters
were observed with the use of the bangles, both by
best predicting neurodevelopmental outcome were
trained and untrained personnel.
the neonatal risk score (P<.05) and the weight and
height at six years of age (P<.05). The children with
intrauterine growth retardation with neonatal
Lang, S., C. J. Lawrence, and R. L. Orme. 1994. complications had lower neurodevelopmental scores
“Cup feeding: an alternative method of infant than the controls but no difference in IQ.
feeding,” Arch. Dis. Child, vol. 71, no. 4, Intrauterine growth retardation children diagnosed
pp. 365–369. prenatally had the same neurodevelopmental and IQ
scores as those diagnosed at birth, probably due to
Abstract: To introduce an unfamiliar procedure the careful perinatal and obstetric care provided.
into a neonatal unit is undoubtably a challenge, Children with intrauterine growth retardation
particularly if it is seen as time consuming. Our demonstrate a specific profile of
experience, however, suggests that the time taken in neurodevelopmental disabilities at preschool age.
cup feeding can vary as widely as the time taken Early diagnosis and intervention could probably
for the bottle or tube feeding, and by teaching the reduce these difficulties to a minimum.
skill to parents, health professionals are free to
attend to other tasks. Helping a mother and infant
to establish breastfeeding in a neonatal unit is also Leon, D. A. 1998. “Fetal growth and adult
not a quick or easy task and any safe measure that disease,” Eur. J. Clin. Nutr., vol. 52 Suppl 1,
will contribute to a successful outcome should be pp. S72–S78.
used. Cup feeding is one such measure, which in
Abstract: Current knowledge on associations
addition allows the introduction of a ‘no-bottle’
between variations in fetal growth on the one hand
policy where appropriate. Cup feeding is an
and blood pressure, noninsulin dependent diabetes,
alternative method of feeding that broadens the
coronary heart disease and cancer in adulthood on
options available to both parents and health
the other is reviewed and related to more
professionals, who may require unconventional
conventional preoccupations of perinatal
197
are of great interest and clearly require Abstract: This paper describes a simple method of
explanation. Although the fetal origins hypothesis assessing maturity that can be use in peripheral
is plausible, and is likely to be pertinent to some facilities and by community health workers who
epidemiological observations, evidence cited for it see the newborn baby in the first two to three days
is often flawed because of misinterpretation and after birth. At these sites, it is really necessary to
inappropriate analysis of growth data. Previous identify only two cut of points, namely <37 weeks
flaws in interpretation may have deflected attention of gestation prior to which risks are higher and
from potentially important areas of postnatal about 34 weeks of gestation below which
development that could prove influential for adult morbidity and mortality are still greater.
health. The most robust test of either the fetal or Method: Note the size of the breast nodule
postnatal origins hypotheses is the randomized (not the nipple). Evaluate the nodule by picking it
intervention study, which has proved, at least in up between the thumb and index finger. The size
some areas, to be feasible. Until such studies are can be noted against a small scale or ruler. Mature
performed, the problem of proving causation using infants with normal growth have nodules above
correlative analyses of early size and later outcome 0.5cm.
will remain. These issues have never been clearly If the nodule is 0.5cm. or less, the baby is
stated before, and published studies have not premature (less than 37 weeks) and/or growth
generally taken them into account. We recommend retarded as intrauterine growth retardation also
that each of the models we discuss above is clearly reduces the breast nodule. This itself will identify a
shown in future publications and that the high risk category. However, further information
interpretation of results takes account of the on maturity can be had by noting the sole creases.
arguments we raise. If the sole creases cover more than 1/3–1/2 the sole,
the baby is mature. If the creases are only in the
front portion within 1/3 of the sole the baby is
Martorell, R., U. Ramakrishnan, D. G. Schroeder, premature—less than 37 weeks.
P. Melgar, and L. Neufeld. 1998. “Intrauterine If the breast nodule is absent the baby is
growth retardation, body size, body preterm—less than 34 weeks and/or growth
composition and physical performance in retarded. Where the breast nodule is absent both
adolescence,” Eur. J. Clin. Nutr., vol. 52 the categories of preterm and growth retarded
Suppl 1, pp. S43–S52. babies are very high risk and need referral for
special care.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
198
Norman, K., R. C. Pattinson, J. de Souza, P. de standardized mortality ratios for cardiovascular
Jong, G. Moller, and G. Kirsten. 1994. disease. RESULTS: Among women and men death
“Ampicillin and metronidazole treatment in rates from cardiovascular disease fell progressively
preterm labour: a multicentre, randomized between the low and high birthweights groups (chi-
controlled trial,” Br. J. Obstet. Gynaecol., square=4.3, p=0.04 for women, chi-square=8.5,
vol. 101, no. 5, pp. 404–408. p<0.005 for men). Cardiovascular deaths in men
but not women were also strongly related to
Abstract: OBJECTIVE: To ascertain whether
weight at one year, falling progressively between
adjuvant ampicillin and metronidazole given to
the low and high weight groups (chi-square=27.5,
women in preterm labor with intact membranes
p<0.0001). The highest cardiovascular death rates
would prolong pregnancy and decrease the
in women were among those with below average
perinatal mortality and morbidity. DESIGN: A
birthweight but above average weight at one year.
multicentre, prospective, randomized controlled
In men the highest rates were among those with
trial. SETTING: Three perinatal centers serving an
below average birthweight and below average
indigent population. SUBJECTS: Eighty-one
weight at one year. CONCLUSION: Relations
women in active preterm labor with otherwise
between cardiovascular disease and birthweight are
uncomplicated singleton pregnancies between
similar in men and women. In men cardiovascular
26 and 34 weeks’ gestation or an ultrasound fetal
disease is also related to weight gain in infancy.
weight estimate of 800g to 1,500g.
INTERVENTIONS: The study group received
ampicillin and metronidazole for five days. The Pojda, J. and L. Kelley. 2002. Low birthweight. A
control group received no antibiotics. In all women report based on the International Low
contractions were suppressed with hexoprenaline Birthweight Symposium and Workshop held on
and indomethacin for 24 hours, and 14–17 June 1999 at the International Centre
betamethasone was given for fetal lung maturity. for Diarrheal Disease Research in Dhaka,
MAIN OUTCOME MEASURES: Days gained and Bangladesh.
perinatal mortality and morbidity. RESULTS: The
study (n=43) and control groups (n=38) were Abstract: This Policy Nutrition Paper summarizes
comparable at entry. In those receiving ampicillin the proceedings of the Low Birthweight (LBW)
and metronidazole the pregnancy was significantly Symposium and Workshop held in Dhaka,
prolonged (median 15 days versus 2.5 days, Bangladesh, in June 1999 with a view of improving
P=0.04) with significantly more women still the Bangladesh Integrated Nutrition Program.
pregnant after seven days (63% versus 37%, Sessions focused on four themes: 1) epidemiology,
P=0.03, OR=0.34, 95% CI: 0.13–0.94). causes, and consequences of LBW; 2) interventions
Significantly more infants in the control group to reduce LBW; 3) critical issues surrounding
developed necrotising enterocolitis than in the nutritional interventions to reduce LBW; and
study group (5 versus 0, P=0.02). CONCLUSION: 4) improving outcomes with regard to LBW. LBW
Adjuvant ampicillin and metronidazole in the infants (<2,500g) are at high risk for morbidity and
management of women in preterm labor with mortality from infectious disease. LBW has
intact membranes significantly prolonged the multiple etiologies; however, prematurity and
pregnancy and decreased neonatal morbidity. intrauterine growth retardation are the two main
199
practical interventions to prevent LBW and to a simple indicator in identifying LBW in
improve the outcome of infants with LBW, community, comparative evaluation of three simple
including those with a strong behavioral change measurements, i.e., circumferences of calf (CC),
component, would have an enormous impact on thigh (TC) and arm (AC) was done with respect to
the health and productivity of individuals and their sensitivity and specificity. Though all the three
society. measurements showed a high degree of correlation
with the birthweight, calf circumference tended to
be most sensitive in identifying almost 95% of
Ramaiya, C., G. Msamanga, S. Massawe, W. LBW infants. Having established the superiority of
Mpanju, and E. Ngwalle. 1994. “Newborn’s CC, a two color tape demarcating LBW zone from
arm circumference as a screening tool of low normal birthweight using 10cm CC as cut off point
birth weight in Temeke District, Dar es Salaam, was tested by two independent investigators and
Tanzania,” Trop. Geogr. Med., vol. 46, no. 5, two ANMs. It was observed that only 5% of cases
pp. 318–321. were misclassified either as LBW or normal weight
Abstract: To determine the extent to which by the tape with hardly any inter individual
newborn’s mid-upper-arm circumference (MUAC) variation. Measurement of calf circumference being
could be used as a screening tool for low simple and easy even in the hands of paramedics, it
birthweight (LBW), we examined a total of would be used as indicator of LBW and neonatal
601 full-term singleton babies delivered at Temeke mortality in the community.
District Hospital in Dar es Salaam, Tanzania,
between January and April 1992. The mean
Ramji, S., J. Marwah, L. Satyanarayana, V.
birthweight and standard deviation (SD) was
Kapani, M. Mohan, and S. K. Bhargava. 1986.
2,826 (+/– 436)g and the MUAC (SD)
“Neonatal thigh circumference as an alternative
9.9 (+/– 0.8)cm with a correlation coefficient of
indicator of low birthweight,” Indian J. Med.
0.88 between MUAC and birthweight (p=0.0001).
Res., vol. 83, pp. 653–654.
The percentage of LBW (<2,500g) and an arm
circumference below 9.5cm were 18.8% and Abstract: To overcome the logistic problems
11.8%, respectively. Use of 9.5cm measurement as associated with weighing the newborn in the field,
a cut-off point in MUAC was found to be a a study was undertaken to assess the usefulness of
significant predictor of low birthweight. The neonatal thigh circumference (TC) as an alternative
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
sensitivity, specificity and positive predictive value to weight in identifying low birthweight infants. A
were 57.5%, 98.8%, and 91.6%, respectively. strong correlation (P<0.001) between thigh
Newborns with a mid-upper-arm circumference circumference (r=0.9180), mid-arm circumference
<9.5cm were 10 times more likely to have a LBW (MAC, r=0.8292) and birthweight was found in
compared with an arm circumference > or = 216 hospital births. A TC of 14.7cm had a better
9.5cm (p=0.0001). In places where the sensitivity and specificity than a MAC of 8.4cm in
conventional scales are not readily available identifying infants weighing <2,500g. Similarly, a
MUAC of 9.5cm could be used as a method to TC of 13.9cm has a better predictive value than a
screen LBW babies in Tanzania. Significant MAC of 8.0cm in detecting infants <2,000g. TC
maternal factors associated with LBW at the first appears to be a reliable and cost effective indicator
antenatal clinic (ANC) booking included: weight for the identification of low birthweight babies in
<43.5kg, height <150cm, age of 14 to 19 years, the field.
positive malaria parasitemia and previous history
of LBW. It is recommended that subjects with the
above risk factors at ANC booking should be Raymond, E. G., N. Tafari, J. F. Troendle, and J.
advised to deliver in hospital. D. Clemens. 1994. “Development of a practical
screening tool to identify preterm, low-
birthweight neonates in Ethiopia,” Lancet,
Raman, L., J. Neela, and N. Balakrishna. 1992. vol. 344, no. 8921, pp. 524–527.
“Comparative evaluation of calf, thigh and arm
Abstract: Preterm, low-birthweight (LBW)
circumferences in detecting low birthweight
newborn infants are at high risk of neonatal
infants—Part II,” Indian Pediatr., vol. 29,
mortality and morbidity and need early referral for
no. 4, pp. 481–484.
special pediatric care. In developing countries,
Abstract: In an earlier study usefulness and validity birthweight and gestational age often cannot be
of calf circumference in the identification of low measured and a practical screening tool based on
birthweight (LBW) infants was reported. To evolve surrogate neonatal body measurements to identify
200
high-risk infants would be very useful. We studied Sociodemographic factors were associated with
a consecutive series of 843 singleton infants born both the decision to initiate expressed milk
at a referral hospital in Addis Ababa, Ethiopia. feedings and the transition to direct breastfeedings.
Gestational age, birthweight, and four body However, factors relating to infant health only
measurements (chest, head, and mid-arm influenced the transition to direct breastfeedings.
circumferences and length) were accurately Intervention programs need to consider the
recorded. We randomly divided the series into sociodemographic factors that influence infant
equal-sized training and validation groups. In the feeding decisions as well as specific challenges
training group, we used a recursive partitioning encountered by mothers of VLBW infants.
technique to develop a simple predictive
algorithm—infants were classified as high risk if
head circumference was 31cm or less or if chest van der, M. J. 1994. “Survival chances of low
circumference was 30cm or less, and were classified birthweight infants in a rural hospital in
as low risk otherwise. When tested in the Ghana,” Trop. Geogr. Med., vol. 46, no. 5, pp.
validation group, this algorithm had sensitivity, 313–317.
specificity, and negative predictive value for Abstract: The birthweight and mortality in hospital
prediction of preterm and LBW births above was recorded of 567 low birthweight (LBW, < or =
90%. Thus, neonatal body measurements can be 2,000g) infants born/admitted during a seven years
combined into a pragmatic, accurate screening tool period in Agogo Hospital situated in the rainforest
suitable for clinical use in developing countries. area of Ghana. One hundred and fifty-two (26.8%)
of these children died in hospital; 87 (57%) of
them in the first 48 hours. The average length of
Smith, M. M., M. Durkin, V. J. Hinton, D.
stay in hospital of the surviving children was
Bellinger, and L. Kuhn. 2003. “Initiation of
11.6 days. The death rate varied from 8.4% in the
breastfeeding among mothers of very low
1,751g to 2,000g group to 83.3% in infants with a
birthweight infants,” Pediatrics, vol. 111, no. 6
birthweight < or = 1,000g. The proportion LBW
Pt 1, pp. 1337–1342.
children to the total newborn population was
Abstract: OBJECTIVE: To examine factors that 5.5%; the proportion of extreme LBW (< or =
predict the initiation of expressed milk feedings 1,000g) to the total number LBW infants was
and the transition to direct breastfeedings among 7.3%. The results are compared with figures from
mothers of very low birthweight (VLBW) infants. other countries, many of them with a more
METHODS: The sample consists of 361 mother- westernized infrastructure. In our setting, no
infant pairs enrolled in a follow-up study of sophisticated equipment and expensive intensive
children aged six to eight years who were born care provisions were available. This descriptive
weighing <1,501g in one of five hospitals between study was carried out to establish the survival rate
1991–1993. Chart review at birth provided data in the neonatal period during the primary stay in
on neonatal characteristics and demographic hospital with low-cost conservative care. Dedicated
factors at delivery were obtained by postpartum staff members, who underwent only a simple
maternal interview. Information regarding infant training program, and mothers participating in the
feeding practices was obtained at follow-up. care for their children contributed to the relatively
201
derived from the last menstrual period (LMP), VLBW infants also frequently cited the influence of
fundal height and the Dubowitz method. The medical professionals and nursery practices as most
smallest difference in gestational age and the most important in the choice of sleeping position. The
narrow limits of agreement were found between factors most strongly associated with prone
the Ballard-ext. and the Dubowitz method. No sleeping were single marital status (odds ratio
reliable gestational age could be obtained from [OR]=3.0; 95% confidence interval [CI]: 1.5–6.2),
LMP or fundal height. At low gestational ages, black race (OR=2.6; 95% CI: 1.5–4.5), birthweight
Ballard-ext. tended to give lower gestational ages <1,500g (OR=2.4; 95% CI: 1.3–4.3), and
compared with the Dubowitz method. At an multiparity (OR=2.1, 95% CI: 1.2–3.5).
average gestational age of more than 251 days, CONCLUSIONS: Prone sleep decreased among
Ballard-ext. gave higher values compared with low birthweight infants from 1995 to 1998.
Dubowitz. Both Ballard-ext. and the Dubowitz However, VLBW infants, who are at very high risk
method identified 48% of low birthweight babies for sudden infant death syndrome, are more likely
as growth-retarded (gestational age > or = 37 to sleep prone than larger low birthweight infants.
weeks). No significant difference in gestational age
assessment of newborns between nurses was
observed. The Ballard method, scoring for external Victora, C. G., P. G. Smith, J. P. Vaughan, L. C.
criteria alone, compared favorably with the Nobre, C. Lombardi, A. M. Teixeira, S. M.
Dubowitz method. The test is simple to perform Fuchs, L. B. Moreira, L. P. Gigante, and F. C.
and can be reliably used routinely by nurses. Barros. 1988. “Influence of birthweight on
mortality from infectious diseases: a case-
control study,” Pediatrics, vol. 81, no. 6,
Vernacchio, L., M. J. Corwin, S. M. Lesko, R. M. pp. 807–811.
Vezina, C. E. Hunt, H. J. Hoffman, M.
Abstract: The association between birthweight and
Willinger, and A. A. Mitchell. 2003. “Sleep
infant mortality from infectious diseases was
position of low birthweight infants,” Pediatrics,
investigated in a population-based case-control
vol. 111, no. 3, pp. 633–640.
study in two urban areas in southern Brazil. All
Abstract: OBJECTIVES: To describe sleep positions deaths of children, seven to 364 days of age,
among low birthweight infants, variations in sleep occurring in a year were studied and the parents of
position according to birthweight, and changes in the 357 infants dying of an infectious cause were
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
sleep position over time. To analyze risk factors interviewed, as were the parents of two
and influences associated with prone sleep. neighborhood control infants for each case. Low
DESIGN: Prospective cohort study. SETTING: birthweight infants (less than 2,500g) were found,
Massachusetts and Ohio, 1995–1998. STUDY after allowing for confounding factors, to be
PARTICIPANTS: Mothers of 907 low birthweight 2.3 (90% confidence interval: 1.6 to 3.4) times
infants. RESULTS: At one, three, and six months more likely to die of an infection than those of
after hospital discharge, the prevalence of prone higher birthweight. The odds ratios were 2.0 (1.1
sleeping was 15.5%, 26.8%, and 28.3%, to 3.6) for deaths due to diarrhea, 1.9 (1.0 to 3.6)
respectively. The corresponding rates for supine for respiratory infections, and 5.0 (1.3 to 18.6) for
sleeping were 23.8%, 37.9%, and 50.2% and for other infections. These estimates of the risks
side sleeping were 57.3%, 32.4%, and 20.6%. associated with low birthweight are considerably
Very low birthweight (VLBW) infants (<1,500g) lower than those from studies in developed
were most likely to be placed in the prone position. countries.
From 1995 through 1998, prone sleeping one
month after hospital discharge declined among all
low birthweight infants from 19.9% to 11.4%; Walraven, G. E., R. J. Mkanje, J. van Roosmalen,
among VLBW infants, the decline in prone sleeping P. W. van Dongen, and W. M. Dolmans. 1994.
was replaced almost entirely by an increase in side “Chest circumference as a screening method for
sleeping, whereas in larger low birthweight infants, low birthweight in newborns in rural
it was replaced primarily by supine sleeping. Tanzania,” Trop. Geogr. Med., vol. 46, no. 1,
Among mothers who placed their infants to sleep pp. 14–16.
in nonprone positions, professional medical advice Abstract: This study examines the value of head-,
was cited most frequently as the most influential chest- and mid-upper arm circumference (MUAC),
reason, whereas among mothers of prone-sleeping and crown-to-coccyx length as a screening method
infants, the infant’s preference was cited most for low birthweight. Results are presented of
frequently. However, mothers of prone-sleeping
202
2,710 consecutive live births, excluding infants Yasmin, S., D. Osrin, E. Paul, and A. Costello.
with severe congenital abnormalities. Chest 2001. “Neonatal mortality of low-birth-weight
circumference (r=0.84) and MUAC (r=0.79) infants in Bangladesh,” Bull. World Health
correlated best with birthweight. Variance in Organ., vol. 79, no. 7, pp. 608–614.
birthweight was explained by chest circumference
Abstract: OBJECTIVE: To ascertain the role of low
in 70%, while a model including all variables
birthweight (LBW) in neonatal mortality in a
accounted for 79%. At a cut-off level of 30.0cm
periurban setting in Bangladesh. METHODS: LBW
for chest circumference, detection rate for
neonates were recruited prospectively and followed
birthweight below 2,500g and 2,000g was 67%
up at one month of age. The cohort of neonates
and 96%, respectively, while false-positive rate was
were recruited after delivery in a hospital in
3% and 10%. At a cut-off level of 9.0cm for
Dhaka, Bangladesh, and 776 were successfully
MUAC, detection rate for birthweight below
followed up either at home or, in the event of early
2,500g and 2,000g was 72% and 95%,
death, in hospital. FINDINGS: The neonatal
respectively, while false-positive rate was 8% and
mortality rate (NMR) for these infants was
15%. Chest circumference is recommended as the
133 per 1,000 live births (95% confidence interval:
first stage screening method of choice for LBW,
110–159). The corresponding NMRs (and
when no weighing scale is available.
confidence intervals) for early and late neonates
were 112 (91–136) and 21 (12–33) per thousand
World Health Organization. 2002. Multicentre live births, respectively. The NMR for infants born
study on low birthweight and infant mortality after fewer than 32 weeks of gestation was
in India, Nepal and Sri Lanka. 769 (563–910); and was 780 (640–885) for infants
whose birthweights were under 1,500g. Eighty-four
Abstract: Describes the design and findings of a percent of neonatal deaths occurred in the first
multicentre study conducted to investigate the seven days; half within 48 hours. Preterm delivery
determinants and consequences of low birthweight was implicated in three-quarters of neonatal
in rural communities of three South Asian deaths, but was associated with only one-third of
countries. India, Nepal and Sri Lanka were selected LBW neonates. CONCLUSION: Policy-relevant
for the study in view of both their high levels of findings were: that LBW approximately doubles
low birthweight and their wide differences in the the NMR in a periurban setting in Bangladesh; that
availability and utilization of maternal and child neonatal mortality tends to occur early; and that
health services. A simultaneous urban, hospital- preterm delivery is the most important contributor
based study was conducted in Nepal to obtain data to the NMR. The group of infants most likely to
on factors associated with low birthweight in a benefit from improvements in low-cost essential
hospital setting. care for the newborn accounted for almost 61% of
Available at: neonatal mortalities in the cohort.
http://www.who.int/dsa/cat98/mat8.htm#
Multicentre Study
Zhou, L. M., W. W. Yang, J. Z. Hua, C. Q. Deng,
X. Tao, and R. J. Stoltzfus. 1998. “Relation of
World Health Organization. 1993. “Use of a hemoglobin measured at different times in
203
10g/liter groupings, with 110g–119g/liter as the 100–109g/liter, 2.63 (1.17–5.90) for 90–99g/liter,
reference group. Rates of low birthweight and and 3.73 (1.36–10.23) for 60–89g/liter. Use of
preterm birth (but not small-for-gestational age) hemoglobin values in the fifth or eighth month
were related to early pregnancy hemoglobin attenuated the association with preterm birth.
concentration in a U-shaped manner. The relative When lowest pregnancy hemoglobin values were
risks (95% confidence intervals) for preterm birth used, the association of anemia with both
in women by g/liter of hemoglobin were 2.52 outcomes was obscured, and risk of preterm birth
(0.95–6.64) for > or = 130g/liter, 1.11 (0.41–2.99) at high hemoglobin values increased dramatically.
for 120–129g/liter, 1.64 (0.77–3.47) for
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
204
Kangaroo Mother Care
Anderson, G. C. 1991. “Current knowledge about Cochrane Central Register of Controlled Trials
skin-to-skin (kangaroo) care for preterm (The Cochrane Library, Issue 4, 2002), MEDLINE
infants,” J. Perinatol., vol. 11, no. 3, (1976 to 2002). SELECTION CRITERIA:
pp. 216–226. Randomized and quasi-randomized clinical trials
comparing early skin-to-skin contact with usual
Abstract: Skin-to-skin (“kangaroo”) care for
hospital care. DATA COLLECTION AND
preterm infants is becoming widespread in Western
ANALYSIS: Two reviewers independently assessed
Europe. During this care the mother holds her
trial quality and extracted data. We contacted
diaper-clad premature infant against her skin
study authors for additional information. We
beneath her clothing and allows self-regulatory
collected adverse effects information from the
access to breastfeeding. Fathers hold their infants
trials. MAIN RESULTS: Seventeen studies,
skin-to-skin also. Research projects in Western
involving 806 participants, were included. We
Europe and the United States provide data that
found statistically significant and positive effects of
support the safety and effectiveness of this method.
early skin-to-skin contact on breastfeeding at one
Infants held skin-to-skin are warm enough and
to three months postbirth (odds ratio (OR)=2.15,
have regular heart rate and respirations, more deep
95% confidence interval (CI): 1.10 to 4.22),
sleep and alert inactivity, less crying, no increase in
breastfeeding duration (weighted mean difference
infections, greater weight gain, and earlier
(WMD)=41.99, 95% CI: 13.97 to 70.00),
discharge. Lactation is more productive and of
maintenance of infant temperature in the neutral
greater duration. Parents become attached to their
thermal range (OR=12.18, 95% CI: 2.04 to 72.91),
infants and feel confident about caring for them.
infant blood glucose (WMD=11.07, 95% CI:
This research is summarized and annotated in a
3.97 to 18.17), infant crying (OR=21.89, 95% CI:
table, along with descriptive reports and
5.19 to 92.30) and summary scores of maternal
videotapes. These data can be used by health care
affectionate love/touch (SMD=0.73, 95% CI:
professionals to make informed decisions about
0.36 to 1.11) during an observed breastfeeding
offering kangaroo care opportunities to selected
within the first few days postbirth. We found no
parents and their preterm infants.
statistically significant benefit of early skin-to-skin
contact for other major clinical variables:
Anderson, G. C., E. Moore, J. Hepworth, and N. breastmilk maturation, maternal chest
Bergman. 2003. “Early skin-to-skin contact for circumference, infant heart rate. REVIEWER’S
mothers and their healthy newborn infants CONCLUSIONS: Limitations included the
(Cochrane Review),” Cochrane. Database. Syst. methodological quality of the studies, variations in
Rev., no. 2, p. CD003519. the implementation of the intervention and
outcome variability. Early skin-to-skin contact
Abstract: BACKGROUND: Early skin-to-skin appears to have some clinical benefit especially
contact involves placing the naked baby prone on regarding breastfeeding outcomes and infant crying
the mother’s bare chest at birth or soon afterwards and has no apparent short or long-term negative
(<24 hours). This could represent a “sensitive effects. Further investigation is recommended. To
period” for priming mothers and infants to develop facilitate meta-analysis of the data, future research
a synchronous, reciprocal, interaction pattern, in this area should involve outcome measures
provided they are together and in intimate contact.
KANGAROO MOTHER CARE
205
Abstract: The results of introducing the “kangaroo Cattaneo, A., R. Davanzo, F. Uxa, and G.
method” (constant nursing of the baby skin to skin Tamburlini. 1998. “Recommendations for the
on the mother’s chest), as the exclusive means of implementation of Kangaroo Mother Care for
treating low birthweight (LBW) babies is reported, low birthweight infants. International Network
in the context of a mission hospital in a developing on Kangaroo Mother Care,” Acta Paediatr.,
country without incubators and standard vol. 87, no. 4, pp. 440–445.
equipment for care of LBW neonates. Details of the
Abstract: Good quality care of low birthweight
method developed are described. The survival of
infants could reduce neonatal mortality in low-
babies born under 1,500g improved from 10% to
income countries, but the technologies used in rich
50%, whereas that of babies 1,500g–1,999g
countries are inappropriate. Kangaroo Mother
improved from 70% to 90%. The method is well
Care does not need expensive and sophisticated
accepted by the community, and easily grasped by
equipment, and for its simplicity it can be applied
all hospital staff. Staff expectations concerning
almost everywhere, including peripheral maternity
survival have dramatically improved, and a
units of very low-income countries. Kangaroo
considerable saving in workload is experienced.
Mother Care (KMC) can also contribute to the
The kangaroo method as described is strongly
humanization of neonatal care and to better
recommended to all units in developing countries
bonding between mother and baby in both poor
treating LBW babies without modern equipment.
and rich countries. A group of health professionals
with experience in KMC met in a workshop to
Bohnhorst, B., T. Heyne, C. S. Peter, and C. F. discuss its effectiveness, safety, applicability and
Poets. 2001. “Skin-to-skin (kangaroo) care, acceptability in different settings: from first and
respiratory control, and thermoregulation,” J. second level maternity units in settings with very
Pediatr., vol. 138, no. 2, pp. 193–197. limited resources, to second and third level units in
settings with limited resources, to second and third
Abstract: OBJECTIVE: To demonstrate that skin- level maternity and neonatal care units in settings
to-skin care (SSC) has no detrimental effects on the with ample resources and infant mortality rates
frequency of episodes of bradycardia and/or <15/1,000. The paper summarizes the
hypoxemia. METHODS: Twenty-two recommendations of this group of health
spontaneously breathing preterm infants (median professionals for the implementation of KMC in
gestational age at birth, 29 weeks [range, 24–31 these various settings, together with suggested
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
ambulatory monitoring. Control infants remained meeting usual discharge criteria. Both groups are
in incubators until the usual discharge criteria were being followed up to 12 months of corrected age;
met. Both groups were followed at term and at 679 (90%) were available for evaluation when they
three, six, nine, and twelve months of corrected reached term (40 to 41 weeks of postconceptional
age. The main outcomes measured were morbidity, age). The present paper reports early outcomes
mortality, growth, development, breastfeeding, (when reaching term) including mortality,
hospital stay, and sequelae. RESULTS: Baseline infectious episodes, hospital stay after eligibility,
variables were evenly distributed, except for weight and growth and feeding patterns. RESULTS: Both
at recruitment (KMC: 1,678g; control participants: study groups were similar regarding all baseline
1,713g). The risk for death was lower among variables but weight at eligibility. The risk of dying
infants who were given KMC, although the was similar in both groups (relative risk=0.59,
207
95% confidence interval: 0.22–1.6). There were no quality of life, especially regarding weight gain and
differences in growth indices. Nosocomial neurodevelopment, that may be answered by a
infections were more frequent in control infants. Randomized Controlled Trial.
Hospital stay after eligibility was shorter in KMC,
primarily for infants </=1,800g. CONCLUSIONS:
These results show that KMC is a safe approach to Charpak, N., Z. F. de Calume, and J. G. Ruiz.
the care of clinically stable LBW infants. Our 2000. “The Bogota Declaration on Kangaroo
findings provide the necessary scientific support to Mother Care: conclusions at the second
a method that is already incorporated in the care of international workshop on the method. Second
LBW infants at many hospitals around the world International Workshop of Kangaroo Mother
and at different levels of care. Care,” Acta Paediatr., vol. 89, no. 9,
pp. 1137–1140.
Abstract: Implementation of a kangaroo mother
Charpak, N., J. G. Ruiz-Pelaez, and Y. Charpak.
care program requires coordinated action by
1994. “Rey-Martinez Kangaroo Mother
national and provincial health authorities and
Program: an alternative way of caring for low
health care facilities at various levels. A kangaroo
birthweight infants? One year mortality in a
mother care program begun under precarious
two cohort study,” Pediatrics , vol. 94, no. 6
conditions might be counterproductive, and the
Pt 1, pp. 804–810.
minimum facilities for safe management must be
Abstract: OBJECTIVES: To assess the effectiveness provided. Although recent data are available on the
and safety of the Kangaroo mother intervention savings achieved with kangaroo mother care, better
(KMI). DESIGN: Observational, analytic, data are needed on the cost-effectiveness of the
prospective (two cohorts) study. SETTING: Two method, particularly for the ambulatory care. More
large tertiary care obstetric hospitals, one offering effective networking among researchers and
“traditional” care and the other KMI. PATIENTS: healthcare providers will be pursued. Kangaroo
Newborn infants with birthweights < or = 2,000g, mother care not only humanizes neonatology, it
who survive the neonatal period and are eligible for also makes better use of human and technological
an in-patient minimal care unit (MCU) (having resources available in developing countries.
overcome major adaptation problems to extra Nevertheless, resistance to change is one the
uterine life). INTERVENTIONS: “Kangaroo obstacles that any new care modality must
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
infants” (KI) were discharged as soon as they were overcome. The task developed by kangaroo mother
eligible for MCU, regardless of weight or gestational care researchers and providers continues to be
age. Infants were kept 24 hours a day in an upright addressed, and even greater interest is expected at
position, in skin-to-skin contact and firmly attached the third workship to be held in Yogyacarta,
to the mother’s chest until the KMI was not Indonesia, in November 2000.
tolerated anymore. Control babies (from the other
facility) were kept in incubators at the MCU until
they satisfied usual discharge criteria for the control Colonna, F., F. Uxa, A. M. da Graca, and U. de
hospital. Both groups were followed periodically up Vonderweld. 1990. “The “kangaroo-mother”
to the age of one year. RESULTS: Three hundred method: evaluation of an alternative model for
thirty-two eligible infants were recruited, 162 at the the care of low birthweight newborns in
Kangaroo hospital and 170 at the control hospital. developing countries,” Int. J. Gynaecol. Obstet.,
KI came from a much lower socio-economic class vol. 31, no. 4, pp. 335–339.
and were more ill before eligibility. Relative risk of Abstract: The “kangaroo-mother” method, that is
death was higher for KI (RR=1.9), although this nursing babies by continuously keeping them
figure was reversed after adjusting for weight at wrapped at the mother’s breasts, has been
birth and gestational age (RR=0.5). KI grew less in proposed as an “appropriate technology” for the
the first three months and had a higher proportion care of low birthweight (LBW) newborns in
of developmental delay at one year, and a developing countries. We evaluated the
multivariate analysis failed to control for the large effectiveness of this method as an alternative
baseline differences in socioeconomic levels and hospital care model in the Special Care nursery of
babies’ health status between the two cohorts. the Central Hospital of Mapto, Mozambique. One
CONCLUSIONS: In spite of major baseline hundred LBW newborns (mean birthweight
differences between studied cohorts, the survival of 1,329g, SD +/– 208g) were consecutively admitted
LBW infants in Bogota is similar between the KMI to the “kangaroo-mother” section of the unit at the
and the “traditional care.” Questions remain about mean postnatal age of 11.6 days. Ninety-five of
208
them were discharged alive after a mean period of 95% confidence interval: 0.14 to 0.67), lower
16.3 days of “kangaroo” nursing. During this respiratory tract disease at six months follow-up
period they were exclusively breastfed and their (relative risk=0.37, 95% confidence interval:
mean weight gain was 12.8g/day. Besides being 0.15 to 0.89), not exclusively breastfeeding at
very effective in improving survival, this method discharge (relative risk=0.41, 95% confidence
favored the development of early mother-infant interval: 0.25 to 0.68), and maternal dissatisfaction
relations, which are certainly very important for with method of care (relative risk=0.41,
the long term well-being of the child. 95% confidence interval: 0.22 to 0.75). KMC
infants had gained more weight per day by
discharge (weighted mean difference=3.6g/day,
Conde-Agudelo, A., J. L. Diaz-Rossello, and J. M. 95% confidence interval: 0.8 to 6.4). Scores on
Belizan. 2003. “Kangaroo mother care to mother’s sense of competence according to infant
reduce morbidity and mortality in low stay in hospital and admission to NICU were better
birthweight infants (Cochrane Review),” in KMC than in control group (weighted mean
Cochrane. Database. Syst. Rev., no. 2, differences 0.31 [95% confidence interval: 0.13 to
p. CD002771. 0.50] and 0.28 [95% confidence interval: 0.11 to
Abstract: BACKGROUND: Kangaroo mother care 0.46], respectively). Scores on mother’s perception
(KMC), defined as skin-to-skin contact between a of social support according to infant stay in NICU
mother and her newborn, frequent and exclusive or were worse in KMC group than in control group
nearly exclusive breastfeeding, and early discharge (weighted mean difference –0.18 (95% confidence
from hospital, has been proposed as an alternative interval: –0.35 to –0.01). There was no evidence of
to conventional neonatal care for low birthweight a difference in infant mortality. However, serious
(LBW) infants. OBJECTIVES: To determine concerns about the methodological quality of the
whether there is evidence to support the use of included trials weaken credibility in these findings.
KMC in LBW infants as an alternative to REVIEWER’S CONCLUSIONS: Although KMC
conventional care after the initial period of appears to reduce severe infant morbidity without
stabilization with conventional care. SEARCH any serious deleterious effect reported, there is still
STRATEGY: We used the standard search strategy insufficient evidence to recommend its routine use
of the Neonatal Review Group of the Cochrane in LBW infants. Well designed randomized
Collaboration. MEDLINE, EMBASE, LILACS, controlled trials of this intervention are needed.
POPLINE and CINAHL databases, and the
Cochrane Controlled Trials Register (Cochrane
Engler, A. J., S. M. Ludington-Hoe, R. M. Cusson,
Library) up to Issue 2—2000 were searched using
R. Adams, M. Bahnsen, E. Brumbaugh, P.
the key words terms “kangaroo mother care” or
Coates, J. Grieb, L. McHargue, D. L. Ryan, M.
“kangaroo mother method” or “skin-to-skin
Settle, and D. Williams. 2002. “Kangaroo care:
contact” and “infants” or “low birthweight
national survey of practice, knowledge, barriers,
infants.” SELECTION CRITERIA: Randomized
and perceptions,” MCN Am. J. Matern. Child
trials comparing KMC and conventional neonatal
Nurs., vol. 27, no. 3, pp. 146–153.
care in LBW infants. DATA COLLECTION AND
ANALYSIS: Trial quality was assessed and data Abstract: PURPOSE: A national survey was
were extracted independently by two reviewers. conducted to assess practice, knowledge, barriers,
Statistical analysis was conducted using the and perceptions regarding Kangaroo Care (KC)—
standard Cochrane Collaboration methods. MAIN the holding of diaper-clad preterm infants skin-to-
RESULTS: Three studies, involving 1,362 infants, skin, chest-to-chest by parents. DESIGN: A
were included. All the trials were conducted in descriptive survey was conducted. METHODS:
KANGAROO MOTHER CARE
developing countries. The studies were of moderate Kangaroo Care Questionnaires (KCQs), developed
to poor methodological quality. The most common for the study, were sent to nurse managers in all
shortcomings were in the areas of blinding hospitals in the United States that were identified
procedures for those who collected the outcomes as providing neonatal intensive care services
measures, handling of drop outs, and completeness (N=1,133), and were to be completed by the nurse
of follow-up. The great majority of results consist most familiar with the practice of KC in that unit.
of results of a single trial. KMC was associated A second KCQ was sent to non-respondents.
with the following reduced risks: nosocomial Descriptive statistics were used to summarize the
infection at 41 weeks’ corrected gestational age data. RESULTS: A response rate of 59% (N=537)
(relative risk=0.49, 95% confidence interval: was achieved. Over 82% of the respondents
0.25 to 0.93), severe illness (relative risk=0.30, reported practicing KC in their neonatal intensive
209
care units (NICUs). Nurses were knowledgeable orientation (p=0.007). Results underscore the role
about KC. Major barriers to practicing KC for of early skin-to-skin contact in the maturation of
certain types of infants were infant safety concerns, the autonomic and circadian systems in preterm
as well as reluctance by nurses, physicians, and infants.
families to initiate or participate in KC. Many
NICUs do not permit KC for certain types of
infants (e.g., those on vasopressors or high- Feldman, R., A. I. Eidelman, L. Sirota, and A.
frequency ventilation). Over 60% of respondents Weller. 2002. “Comparison of skin-to-skin
agreed that low gestational age or weight were not (kangaroo) and traditional care: parenting
contraindications. Respondents from NICUs in outcomes and preterm infant development,”
which KC is practiced were more positive in their Pediatr., vol. 110, no. 1 Pt 1, pp. 16–26.
perceptions than respondents from NICUs that do Abstract: OBJECTIVE: To examine whether the
not practice KC. CLINICAL IMPLICATIONS: The kangaroo care (KC) intervention in premature
findings suggest that in order to overcome barriers infants affects parent-child interactions and infant
to the practice of KC, nurses need educational development. METHODS: Seventy-three preterm
offerings highlighting the knowledge and skills infants who received KC in the neonatal intensive
needed to provide KC safely and effectively. These care unit were matched with 73 control infants
educational offerings should also emphasize the who received standard incubator care for
value of KC to infants and parents. In addition, birthweight, gestational age (GA), medical severity,
knowledgeable practitioners need to develop and demographics. At 37 weeks’ GA, mother-
evidence-based policies and procedures that will infant interaction, maternal depression, and mother
lead to successful KC. perceptions were examined. At three months’
corrected age, infant temperament, maternal and
paternal sensitivity, and the home environment
Feldman, R. and A. I. Eidelman. 2003. “Skin-to-
(with the Home Observation for Measurement of
skin contact (Kangaroo Care) accelerates
the Environment [HOME]) were observed. At six
autonomic and neurobehavioral maturation in
months’ corrected age, cognitive development was
preterm infants,” Dev. Med. Child Neurol.,
measured with the Bayley-II and mother-infant
vol. 45, no. 4, pp. 274–281.
interaction was filmed. Seven clusters of outcomes
Abstract: The effects of mother-infant skin-to-skin were examined at three time periods: at 37 weeks’
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
contact (Kangaroo Care; KC) on autonomic GA, mother-infant interaction and maternal
functioning, state regulation, and neurobehavioral perceptions; at three-months, HOME mothers,
status was examined in 70 preterm infants, half of HOME fathers, and infant temperament; at six
whom received KC over 24.31 days (SD 7.24) for a months, cognitive development and mother-infant
total of 29.76 hours (SD 12.86). Infants were interaction. RESULTS: After KC, interactions were
matched for sex (19 males and 16 females in each more positive at 37 weeks’ GA: mothers showed
group); birthweight (KC, 1,229.95g [SD 320.21]; more positive affect, touch, and adaptation to
controls, 1,232.17g [SD 322.15]); gestational age infant cues, and infants showed more alertness and
(GA) (KC, 30.28 weeks [SD 2.54]; controls, less gaze aversion. Mothers reported less
30.19 weeks [SD 2.65]); medical risk; and family depression and perceived infants as less abnormal.
demographics. Vagal tone was calculated from At three months, mothers and fathers of KC
10 minutes of heart rate before KC and again at infants were more sensitive and provided a better
37 weeks’ GA. Infant state was observed in home environment. At six months, KC mothers
10-second epochs during four consecutive hours were more sensitive and infants scored higher on
before KC and again at 37 weeks’ GA. the Bayley Mental Developmental Index (KC:
neurobehavioral status was assessed at 37 weeks’ mean: 96.39; controls: mean: 91.81) and the
GA with the Neonatal Behavioral Assessment Scale Psychomotor Developmental Index (KC: mean:
(NBAS). Infants receiving KC showed a more rapid 85.47; controls: mean: 80.53). CONCLUSIONS:
maturation of vagal tone between 32 and KC had a significant positive impact on the infant’s
37 weeks’ GA (p=0.029). More rapid improvement perceptual-cognitive and motor development and
in state organization was observed in KC infants, on the parenting process. We speculate that KC has
in terms of longer periods of quiet sleep (p=0.016) both a direct impact on infant development by
and alert wakefulness (p=0.013) and shorter contributing to neurophysiological organization
periods of active sleep (p=0.023). and an indirect effect by improving parental mood,
Neurodevelopmental profile was more mature for perceptions, and interactive behavior.
KC infants, particularly habituation (p=0.032) and
210
Feldman, R., A. Weller, L. Sirota, and A. I. Kambarami, R. A., J. Mutambirwa, and P. P.
Eidelman. 2003. “Testing a family intervention Maramba. 2002. “Caregivers’ perceptions and
hypothesis: the contribution of mother-infant experiences of ‘kangaroo care’ in a developing
skin-to-skin contact (kangaroo care) to family country,” Trop. Doct., vol. 32, no. 3,
interaction, proximity, and touch,” J. Fam. pp. 131–133.
Psychol., vol. 17, no. 1, pp. 94–107.
Abstract: The widespread use of “kangaroo care”
Abstract: The provision of maternal-infant body is yet to be realized despite strong evidence to
contact during a period of maternal separation was suggest that this method of preterm care is safe,
examined for its effects on parent-infant and triadic effective and affordable. We need to understand
interactions. Participants were 146 three-month-old users’ perception of this method of care. We
preterm infants and their parents, half of whom studied, through focus group discussions,
received skin-to-skin contact, or kangaroo care caregivers’ experiences and perceptions of this
(KC), in the neonatal nursery. Global relational method in a tertiary level hospital of a developing
style and micro-patterns of proximity and touch country. We conclude that, in this hospital,
were coded. Following KC, mothers and fathers caregivers preferred kangaroo care to conventional
were more sensitive and less intrusive, infants methods. Communities’ awareness of this method
showed less negative affect, and family style was of care and its advantages must be improved.
more cohesive. Among KC families, maternal and
paternal affectionate touch of infant and spouse
was more frequent, spouses remained in closer Kambarami, R. A., O. Chidede, and D. T. Kowo.
proximity, and infant proximity position was 1999. “Kangaroo care for well low birthweight
conducive to mutual gaze and touch during triadic infants at Harare Central Hospital Maternity
play. The role of touch as a constituent of the co- Unit—Zimbabwe,” Cent. Afr. J. Med., vol. 45,
regulatory parent-infant and triadic systems and no. 3, pp. 56–59.
the effects of maternal contact on mothering, co- Abstract: OBJECTIVE: To describe the experience
parenting, and family processes are discussed. in a newly established Kangaroo Care Unit (KCU)
at a tertiary level hospital and to identify factors
associated with poor outcome in this unit.
Gloppestad, K. 1996, “Parents’ skin to skin
DESIGN: Cross sectional study. SETTING:
holding of small premature infants: differences
Kangaroo Care Unit at Harare Central Hospital,
between fathers and mothers,” Vard. Nord.
Zimbabwe. SUBJECTS: Mothers admitted to the
Utveckl. Forsk., vol. 16, no. 1, pp. 22–27.
KCU and their well preterm infants. MAIN
Abstract: AIM: Both mothers and fathers should OUTCOME MEASURES: Discharge home or
achieve early skin to skin holding of their small referral back to the Neonatal Unit (NNU) for
premature infants, despite the infants’ need for conventional care. RESULTS: Six hundred and
breathing equipment, including respirator. If the thirteen mother infant pairs were studied from
mother needs to wait to hold her newborn due to May 1994 to December 1996. The median age for
her medical condition, this is not reason enough all mothers was 23 years (Q1=15, Q3=26). Fifty-
for the father also to wait. PURPOSE/QUESTION: four percent of the infants were female. Median
Do fathers wait significantly longer post delivery to age at admission to KCU was 12 days (Q1=1,
hold their small premature infants skin to skin Q3=25). Seventy-two percent of infants were
(kangaroo) than mothers do? METHODS: discharged home from the KCU. The rest (28%)
Registration-schedule, existing sources of data, and were referred back to NNU for conventional care.
interviews were used. FINDING/CONCLUSION: The odds of being referred back to the NNU were
KANGAROO MOTHER CARE
The time from birth (hours) until fathers held their significantly higher if the infant was male
small premature infants skin to skin was [OR=1.82 (95% CI: 1.25 to 2.66)]; if the
significantly different (p=0.0004) compared to birthweight was <1,500grams [OR=1.52 (95% CI:
mothers. Fathers held their infants later than did 1.04 to 2.22)]; if the admission weight to the KCU
mothers, despite the fact that fathers saw their was <1,500grams [OR=2.16 (95% CI: 1.42 to
infants before the mothers did. Compared to the 3.29)] or if the age on admission to KCU was
mothers the average waiting time before fathers 14 days or more [OR=2.15 (95% CI: 1.44 to
first held their infants skin to skin showed a 3.29)]. These factors remained significant after
difference of 120.9% (difference of the median). adjusting for confounding. Mother’s age, parity,
booking status or whether admission was during
the cold months or not had no significant bearing
211
on the outcome in this unit. Reasons for referral 297 preterm infants born at Harare Hospital
back to NNU included apnea (27%); respiratory weighing 500g–1,800g, discharged home on
distress (27%); aspiration pneumonia (18%); kangaroo care and followed up for 12 months. Of
neonatal jaundice (8%); poor feeding (7%); ill these, 79 (26.6%) died, 141 (47.5%) survived to
mother (5%); sepsis (4%) and diarrhea (3%). On complete follow-up, and 77 (25.9%) were lost to
multivariate analysis birthweight was the strongest follow-up. Of those who died, median birthweight
predictor for being referred back to the NNU was 1,460g, median age at hospital discharge
[OR=10.753 (95% CI: 6.026–19.186)]. seven days, median weight at discharge 1,400g and
CONCLUSION: Establishment of a KCU at a median age at death 66 days. Of those who
tertiary level hospital is feasible. Kangaroo care for completed follow-up, median birthweight was
well preterm infants is suitable for most mothers 1,575g, median age at hospital discharge was
and their preterm infants. Infants were more likely six days and median weight at hospital discharge
to be referred back for conventional care if they was 1,500g. Of those who were lost to follow-up,
were male, very low birthweight and if the age at median age at loss to follow-up was 70 days,
admission was greater than two weeks. Further median birthweight was 1,540g, median age at
studies are needed to determine the long term hospital discharge was five days and median weight
survival of these infants. at hospital discharge was 1,500g. The hospital re-
admission rate was 22.9% with 8.8% mortality.
Maternal mortality and chronic morbidity rates
Kambarami, R. A., O. Chidede, and D. T. Kowo. were 4.7% and 7.4%, respectively. On comparing
1998. “Kangaroo care versus incubator care in those who died with those who completed follow-
the management of well preterm infants—a up, mother’s age <20 years, birthweight <1,500g
pilot study,” Ann. Trop. Paediatr., vol. 18, and maternal mortality and chronic morbidity were
no. 2, pp. 81–86. significant risk factors for infant mortality. Age at
Abstract: This pilot study was conducted to discharge and weight at birth and on discharge
compare the effectiveness of the kangaroo care were not significantly associated with infant
method with current, mainly incubator-based care mortality.
in managing well preterm infants in a tertiary level
hospital in a developing country. Altogether,
Kirsten, G. F., N. J. Bergman, and F. M. Hann.
74 infants (37 per group) were consecutively
2001. “Kangaroo mother care in the nursery,”
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
Kambarami, R. A., O. Chidede, and N. Pereira. Legault, M. and C. Goulet. 1995. “Comparison of
2003. “Long-term outcome of preterm infants kangaroo and traditional methods of removing
discharged home on kangaroo care in a preterm infants from incubators,” J. Obstet.
developing country,” Ann. Trop. Paediatr., Gynecol. Neonatal Nurs., vol. 24, no. 6,
vol. 23, no. 1, pp. 55–59. pp. 501–506.
Abstract: Several hospital-based studies have Abstract: OBJECTIVE: To compare the kangaroo
shown the beneficial effect of kangaroo care on and traditional methods of removing an infant
preterm infants. Long-term outcome was studied in from an incubator in terms of four physiologic
212
parameters, mother’s satisfaction, and mother’s Lincetto, O., A. I. Nazir, and A. Cattaneo. 2000.
preference. DESIGN: Time-series design (quasi- “Kangaroo mother care with limited resources,”
experimental), with infant-mother dyads subjected J. Trop. Pediatr., vol. 46, no. 5, pp. 293–295.
to both methods. SETTING: Intermediate neonatal
Abstract: Kangaroo mother care (KMC) for low
care unit in a tertiary hospital in Canada.
birthweight infants (LBWI) was introduced in a
PARTICIPANTS: A convenience sample of
Mozambican hospital with limited resources and
71 infant-mother dyads. INTERVENTION AND
without facilities for intensive care. Six months
MEASURES: The intervention was use of the
were needed to change policies, organize the ward,
kangaroo or traditional method of maintaining
train staff and overcome constraints. Facilitating
body temperature of preterm infants. The
factors were a KMC national policy, the
dependent variables were physiologic parameters
commitment of health authorities, technical
(skin temperature, heart rate, respiratory rate, and
assistance and availability of some funds, and the
oxygen saturation) measured five times with each
perception of improved quality of care and
method. Mother’s satisfaction was measured at the
survival. The obstacles and constraints were
end of each testing period and mother’s preference
resistance to change by the staff, cultural problems,
at the end of the experiment. RESULTS: The
and managerial difficulties. Out of 32 LBWI
kangaroo method produced less variation in
(< or = 1,800g) admitted in three months, survival
oxygen saturation and longer duration of testing,
was 73% in 22 KMC and 20% in 10 non-KMC
and it was preferred by most of the mothers.
infants (p<0.01). KMC is a feasible and
CONCLUSIONS: The kangaroo method is safe for
appropriate technology in hospitals with very
the preterm infant and allows for early contact
limited resources.
between parents and infants.
thermoneutral range. With few exceptions, heart and 13 control infants using a pretest-test-posttest
rate, respiratory rate, and oxygen saturation design of three consecutive interfeeding intervals of
remained within normal limits; grunting 2.5 hours to 3.0 hours duration each was
respirations in two neonates disappeared with conducted over one day. Infant abdominal and toe
warmed humidified oxygen and continuous KC. temperatures were measured in and out of the
Sleep predominated, and neonates were discharged incubator; maternal breast temperature was
home by 48 hours being fully breastfed, suggesting measured during KC. Repeated measures ANOVA
that KC was an environment conducive to recovery showed no change in abdominal temperature
from fatigue. CONCLUSIONS: These data suggest across all periods and between groups. Toe
that KC beginning in the delivery room can be temperatures were significantly higher during KC
given safely and perhaps with benefit to than incubator periods, and maternal breast
34–36-week gestation neonates who appear healthy temperature met each infant’s neutral thermal zone
at birth. Kangaroo care was conducive to recovery requirements within five minutes of onset of KC.
from birth-related fatigue. Preterm infants similar to those studied here will
maintain body warmth with up to three hours of
KC.
Ludington-Hoe, S. M., M. S. Hashemi, L. A.
Argote, G. Medellin, and H. Rey. 1992.
“Selected physiologic measures and behavior Meyer, K. and G. C. Anderson. 1999. “Using
during paternal skin contact with Colombian kangaroo care in a clinical setting with fullterm
preterm infants,” J. Dev. Physiol, vol. 18, no. 5, infants having breastfeeding difficulties,” MCN
pp. 223–232. Am. J. Matern. Child Nurs., vol. 24, no. 4,
pp. 190–192.
Abstract: A descriptive study of eleven healthy
preterm infants was conducted in which Abstract: Usually Kangaroo Care (KC) or skin-to-
cardiorespiratory (heart and respiratory rates, skin holding care is done with preterm infants.
oxygen saturation), thermal (abdominal, toe and This article, however, documents clinical
214
experiences with three mothers and their fullterm Roberts, K. L., C. Paynter, and B. McEwan. 2000.
infants who were having latching/breastfeeding “A comparison of kangaroo mother care and
difficulties. In each case the nurse placed the conventional cuddling care,” Neonatal Netw.,
fullterm infant in KC for approximately one hour vol. 19, no. 4, pp. 31–35.
prior to and continuing into the next breastfeeding
Abstract: PURPOSE: To compare kangaroo mother
session. Although no recommendations can be
care (KMC) and conventional cuddling care (CCC)
made based on case studies, these clinical
in premature and small-for-gestational-age infants.
experiences suggest that KC is a worthwhile
DESIGN AND SAMPLE: Thirty mother-infant
intervention to try when a mother and her fullterm
dyads in two Australian neonatal nurseries were
infant are struggling to achieve successful
randomly assigned to the KMC group or the CCC
breastfeeding.
group. Both groups of mothers cuddled their babies
for a minimum of two hours a day, five days a
Ramanathan, K., V. K. Paul, A. K. Deorari, U. week while in the study, with the KMC group
Taneja, and G. George. 2001. “Kangaroo having skin-to-skin contact while the CCC group
Mother Care in very low birthweight infants,” had contact through normal clothing. MAIN
Indian J. Pediatr., vol. 68, no. 11, OUTCOME VARIABLE: The main outcome
pp. 1019–1023. variables were infant weight gain, temperature
maintenance during KMC and CCC, and length of
Abstract: OBJECTIVE: This study was conducted hospital stay. RESULTS: The results showed no
(i) to study through a randomized control trial the difference between groups on the Parental Stress
effect of Kangaroo Mother Care (KMC) on Scale (NICU) or the Parental Expectations Survey.
breastfeeding rates, weight gain and length of Infants in both groups experienced equivalent
hospitalization of very low birth neonates and (ii) maintenance of or rise in temperature while out of
to assess the acceptability of Kangaroo Mother the incubators, equal weight gain, equal length of
Care by nurses and mothers. METHODS: Babies stay in the hospital, and equal duration of
whose birthweight was less than 1,500g were breastfeeding.
included in the study once they were stable. The
effect of Kangaroo Mother Care on breastfeeding
rates, weight gain and length of hospitalization of
very low birthweight neonates was studied through Ruiz, J. G., N. Charpak, and Z. Figuero. 2002.
a randomized control trial in 28 neonates. The “Predictional need for supplementing
Kangaroo group (n=14) was subjected to Kangaroo breastfeeding in preterm infants under
Mother Care of at least four hours per day in not Kangaroo Mother Care,” Acta Paediatr.,
more than three sittings. The babies received vol. 91, no. 10, pp. 1130–1134.
Kangaroo Care after shifting out from NICU and
Abstract: It has been estimated that 95% of low-
at home. The control group (n=14) received only
birthweight infants are born in developing
standard care (incubator or open care system).
countries. Nevertheless, most of the globally
Attitude of mothers and nurses towards KMC was
available resources are invested in developed
assessed on day 3 +/– 1 and on day 7 +/– 1 after
countries, both for sophisticated, expensive
starting Kangaroo Care in a questionnaire using
technological care and for research focused on
Likert’s scale. RESULTS: The results of the clinical
solving problems in scenarios in which access to
trial reveal that the neonates in the KMC group
expensive resources is available. Very little research
demonstrated better weight gain after the first
on scientifically sound, economically accessible
week of life (15.9 +/– 4.5g/day vs. 10.6 +/–
interventions reaches internationally recognized
4.5g/day in the KMC group and control group
KANGAROO MOTHER CARE
215
nutritional needs differ from those weighing infections; 7 [5%] vs. 27 [18%], p<0.002),
<1,200g, who represent a significantly smaller although differences between the groups in less
proportion. In developing countries, fortification of severe morbidity were not significant. There was
breastmilk is seldom a feasible option. Even no significant difference in growth or in the
supplementing breastmilk with formula implies an proportion of women breastfeeding, perhaps
expense that cannot always be covered. In because the proportion breastfeeding was high in
addition, many preterm infants (particularly those both groups owing to strong promotion. Mortality
weighing >1,200g) can grow properly on exclusive was the same in both groups; most deaths occurred
breastfeeding. In our experience, about 45% of during the stabilization period before
infants under ambulatory Kangaroo Mother Care randomization. KMM mothers made more
(KMC) thrive properly. The choice between giving unscheduled clinic visits than control mothers but
and withholding supplementation for all preterm their infants had fewer re-admissions and so the
infants is not an ethical issue, because there is no cost of care was lower with the KMM. Since the
choice. This was the justification for conducting eligibility criteria excluded nearly 50% of LBW
the study reported here, which attempts to answer infants from the study, the KMM is not universally
the question of how to identify, as early as applicable to these infants. The benefits might be
possible, those premature infants who survive the greater in populations where breastfeeding is not so
early neonatal period and have no obvious risk common.
factors for inadequate growth other than
prematurity, but who are less likely to thrive with
exclusive breastfeeding. Conclusion: The answer to Tessier, R., M. Cristo, S. Velez, M. Giron, Z. F. de
this question will allow us to use our meagre Calume, J. G. Ruiz-Palaez, Y. Charpak, and N.
resources in the most reasonable way, as Charpak. 1998. “Kangaroo mother care and
supplementing breastmilk involves not only the the bonding hypothesis,” Pediatr., vol. 102,
direct cost of the formula but also that of training no. 2, p. e17.
the mothers in techniques for feeding their infants Abstract: BACKGROUND: Based on the general
without compromising breastfeeding or increasing bonding hypothesis, it is suggested that kangaroo
the risk of infectious diseases. mother care (KMC) creates a climate in the family
whereby parents become prone to sensitive
caregiving. The general hypothesis is that skin-to-
Sloan, N. L., L. W. Camacho, E. P. Rojas, and C.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
216
position, with direct skin-to-skin contact. The Whitelaw, A. and K. Liestol. 1994. “Mortality and
second component is kangaroo nutrition. Although growth of low birthweight infants on the
breastfeeding is the prime source of nutrition, Kangaroo Mother Program in Bogota,
infants also may receive preterm formula whenever Colombia,” Pediatr., vol. 94, no. 6 Pt 1,
necessary and vitamin supplements. The third pp. 931–932.
component is the clinical control; infants are
Abstract: Mortality was high at the Instituto
monitored on a regular basis, daily until they are
Materno Infantil in Bogota, Colombia, among low
gaining at least 20g per day. Afterward, weekly
birthweight infants when hospital care was
clinic visits are scheduled until term, which
attempted, neonatal intensive care was virtually
constitutes the ambulatory minimal neonatal care.
nonexistent, and nosocomial infection was
In the TC group, infants are kept in incubators
common. The Kangaroo Mother Program was
until they are able to self-regulate their temperature
therefore launched by Drs. Rey and Martinez in
and are thriving (ie, have an appropriate weight
1978 to educate and motivate mothers as babies’
gain). Infants are discharged according to current
main resource, discharge home regardless of weight
hospital practice, usually not before their weight is
as early as possible to minimize nosocomial
approximately 1,700g. Afterward, as with the
infection, promote exclusive breastfeeding,
KMC group, weekly clinic visits are scheduled until
encourage bonding and keeping the baby warm by
term. RESULTS: We observed a change in the
skin-to-skin contact inside the mother’s clothes,
mothers’ perception of her child, attributable to the
and encourage placing babies in a vertical position
skin-to-skin contact in the kangaroo-carrying
between the mother’s breasts to minimize reflux
position. This effect is related to a subjective
and aspiration. UNICEF provided extra funding
“bonding effect” that may be understood readily
and an ambulatory clinic was built to supervise
by the empowering nature of the KMC
mothers and infants after discharge. Mortality was
intervention. Moreover, in stressful situations when
claimed to be as low for babies below 1,500g
the infant has to remain in the hospital longer,
birthweight as with conventional neonatal intensive
mothers practicing KMC feel more competent than
care. There has since been great interest from
do mothers in the TC group. This is what we call a
around the world in this imaginative approach, but
resilience effect. In these stressful situations we also
amid calls for better documentation before it is
found a negative effect on the feelings of received
widely applied. The authors report on Charpak et
support of mothers practicing KMC. We interpret
al’s exploration of whether the full kangaroo
this as an isolation effect. To thwart this
program with very early discharge results in better
deleterious effect, we would suggest adding social
or worse survival than conventional care, if relying
support as an integral component of KMC. The
upon the baby’s ability to suck from the breast
observations of the mothers’ sensitive behavior did
provides adequate nutrition and growth, and
not show a definite bonding effect, but rather a
whether the early close contact between mother
resilience effect. This is attributable to the KMC
and baby results in measurably better development
intervention; mothers practicing KMC were more
later in life. Charpak compared infants with
responsive to an at-risk infant whose development
birthweights under 2,000g in the kangaroo mother
has been threatened by a longer hospital stay.
program with infants who would have been eligible
Otherwise, we observed that the mothers (in both
for kangaroo care at a large maternity department
the KMC group and the TC group) had behavioral
in the same city with conventional neonatal care.
patterns that were adapted to the child’s at-risk
The data were collected prospectively and
health status and to the precarious condition of
simultaneously with complete follow-up on 290
some premature infants requiring intensive care.
infants. The two populations of infants were nearly
We conclude that the infant’s health status may be
identical in gestational age, albeit with a slightly
KANGAROO MOTHER CARE
217
and gestational age, the investigators found a lower availability. The mean difference between the two
mortality risk in the kangaroo care group. groups in hospitalization time in the first year was
Although breastfeeding was consistently better- only two days, casting doubt upon the idea that
maintained in the kangaroo mother group up to kangaroo care saved substantial amounts of money.
12 months, the kangaroo program babies were The authors note the limitations of the Charpak et
retarded in growth up to 12 months, most likely al. paper, but hail the work as a significant
due to their inability to suck adequate volumes of achievement.
milk from the breast despite its constant
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
218
Birth Asphyxia and Resuscitation
Aggarwal, R., A. K. Deorari, and V. K. Paul. 2001. 1996 and March 31, 1998. RESULTS: 1) The
“Post-resuscitation management of asphyxiated incidence of a poor neurologic outcome, including
neonates,” Indian J. Pediatr. , vol. 68, no. 12, 15 neurologic sequelae and six deaths, was
pp. 1149–1153. 13.8% among the subjects. 2) The risk of a poor
outcome was increased by 13-fold in neonates with
Abstract: Perinatal asphyxia is one of the common
adverse neurological signs and 31-fold in those
causes of neonatal mortality. Data from National
with hypoxic ischemic encephalopathy.
Neonatal Perinatal database suggest that perinatal
CONCLUSION: The incidence of poor neurologic
asphyxia contributes to almost 20% of neonatal
outcome was very high among term infants with
deaths in India. Failure to initiate or sustain
low Apgar scores. These infants were 10 times to
respiration after birth has been defined as criteria
20 times more likely to die, or to survive with
for the diagnosis of asphyxia by WHO. Perinatal
permanent disabilities, than were infants without
asphyxia results in hypoxic injury to various
low Apgar scores.
organs including kidneys, lungs and liver but the
most serious effects are seen on the central nervous
system. Levene’s classification is a useful clinical Boithias-Guerot, C., C. Castel, C. Dubois, V.
tool for grading the severity of hypoxic ischemic Zupan-Simunek, and M. Vial. 2003.
encephalopathy. Good supportive care is essential “Orientation after peripartum asphyxia in the
in the first 48 hours after asphyxia to prevent maternity ward: which infants should be
ongoing brain injury in the penumbra region. Strict transferred to pediatric care units?,” J. Gynecol.
monitoring and prompt correction is needed for Obstet. Biol. Reprod. (Paris), vol. 32, no. 1
common problems including temperature Suppl, pp. 1S91–1S97.
maintenance, blood sugars, blood pressure and
oxygenation. Phenobarbitone is the drug of choice Abstract: Per-partum anoxia is a frequent situation
for the treatment of convulsions. facing the pediatrician in the maternity ward. The
question is to decide which infants require care in a
specialized unit. If transfer is decided, the infant
Aggarwal, R., V. K. Paul, and A. K. Deorari. 2003. must be referred to an appropriate pediatric unit
“Latest guidelines on neonatal resuscitation,” (intensive care or neonatal unit). Cases of severe
Indian J. Pediatr., vol. 70, no. 1, pp. 51–55. anoxia are exceptional. Intermediary situations are
however much more frequent and raise difficult
Abstract: Full text available at:
evaluation problems due to the lack of any specific
http://www.springerlink.com/app/home/content.asp
test. The pediatrician must rely on a combination
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of elements from the clinical presentation, the
ibutionandformat=2andpage=1
medical history, the clinical course, and laboratory
tests. Different elements suggest a prudent
Asakura, H., H. Ichikawa, M. Nakabayashi, K. approach with referral to a pediatric unit. These
BIRTH ASPHYXIA AND RESUSCITATION
Ando, K. Kaneko, M. Kawabata, A. Tani, M. elements include: imperfect clinical recovery
Satoh, K. Takahashi, and S. Sakamoto. 2000. (5-minute Agpar <7), major intensive care at
“Perinatal risk factors related to neurologic delivery (intubation, ventilation, vasoactive agents),
outcomes of term newborns with asphyxia at anomalies in the cord blood or first hour blood
birth: a prospective study,” J. Obstet. Gynaecol. tests (cord pH<7, base deficit 12, cord or blood
Res., vol. 26, no. 5, pp. 313–324. lactate 9 mmol/l). Obstetrical circumstances which
led to per-partum anoxia must be well identified
Abstract: OBJECTIVES: The incidence of poor because those interrupting placental flow (abruptio
neurologic outcomes was studied in term newborns placenta, uterine rupture) suggest prudence is
who had suffered severe asphyxia at birth. necessary even if the infant appears to have
METHODS: Subjects were 152 newborns admitted recovered well. All neonatal disorders
to the NICU with a low Apgar score at 1 or 5 (macrosomia, prematurity, infection, respiratory
minutes. A one-year prospective follow-up of distress) increase the risk of rapid decompensation
neurological outcomes was carried out by a and may argue for hospitalization. Likewise, if
questionnaire survey concluded between April 1, even minimal signs of neurological, respiratory or
219
hemodynamic disorders are present from birth to and maternity homes, were trained in the NRP.
two hours, surveillance in a specialized unit is CONCLUSION: Dissemination of the NRP in
required, the level depending on local facilities. Malaysia during the first two years was very
Certain situations nevertheless always require encouraging. Further efforts should be made to
referral to a pediatric intensive care unit: use of spread the program to private hospitals and the
vasoactive drugs, respiratory distress, abnormal maternal and child health services. In view of the
neurological exam, poor recovery (5-minute Agpar large number of inactive instructors, the criteria for
<4). Finally, it must be remembered that per- future selection of instructors should be more
partum anoxia is rarely predictable and can occur stringent.
any at any time of day or night. The pediatrician
must also train other delivery room personnel,
including the midwives, in intensive care Boyle, R. J. and N. McIntosh. 2001. “Ethical
techniques. considerations in neonatal resuscitation: clinical
and research issues,” Semin. Neonatol., vol. 6,
no. 3, pp. 261–269.
Boo, N. Y. and K. M. Pong. 2001. “Neonatal
Abstract: The recent publication of guidelines for
resuscitation training program in Malaysia:
ethical decision making for resuscitation of infants
results of the first 2 years,” J. Paediatr. Child
has highlighted the problems inherent in using the
Health, vol. 37, no. 2, pp. 118–124.
currently available data to define those situations
Abstract: OBJECTIVES: To determine the number in which resuscitation should be or might be
of providers and instructors trained by the initial withheld or withdrawn. Prior selection criteria for
37 core instructors during the first two years resuscitation, criteria for inclusion into the study
following the launch of the Malaysian Neonatal group, incomplete resuscitation, gestational age
Resuscitation Program (NRP). To identify determination, intrauterine growth restriction,
remediable problems which interfered with the subjective assessment of “poor” outcome, and
propagation of the NRP in Malaysia. other factors make setting specific parameters for
METHODOLOGY: A prospective observational acting or not acting difficult, if not dangerous, and
study carried out over a two-year period between possibly impossible. Research in neonatal
2 September 1996 to 2 September 1998. For every resuscitation poses some potential ethical obstacles,
training course conducted, the instructors but national and international regulations and
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
completed a NRP course report form (Form A) that guidelines are available to assist investigators in
documented the instructors involved in the course. study design.
For every participant who attended the course and
successfully completed it, the instructors submitted
a record form (Form B) that contained the name, Daga, A. S., S. R. Daga, and S. K. Patole. 1990.
hospital address, department, profession, place of “Risk assessment in birth asphyxia,” J. Trop.
work, language used for training and the marks Pediatr., vol. 36, no. 1, pp. 34–39.
obtained by the individual participant. After each Abstract: In developing countries the need for a
course, completed forms A and B were returned to risk approach in neonatology is obvious because of
the NRP secretariat for compilation. RESULTS: Of a high birth rate, high neonatal mortality rate, and
the 37 core instructors, 35 (94.6%) carried out limited availability of resources. Quantification of
training courses in their respective home states. A risk, with selected antepartum, intrapartum factors,
further 513 new instructors and 2,256 providers clinical, and post-mortem findings was done by
were trained subsequently. A total of 2,806 health calculating odds ratio, attributable risk, and
personnel from all 13 states of Malaysia were NRP- 95% confidence limits in 1,811 babies, 541 of
certified during the first two years. However, which were asphyxiated. Primigravidity, history of
61.2% (n=335) of the 550 instructors were inactive perinatal death, pregnancy induced hypertension,
trainers, having trained less than four personnel per and antepartum hemorrhage carried higher risk.
instructor a year. Most of the NRP-certified Abnormal fetal heart rate and meconium passage
personnel were either doctors (32.0%) or nursing in amniotic fluid correctly predicted high risk of
staff (64.4%). More than 60% of these worked birth asphyxia. Decreasing risk in premature/low
either in the labor rooms, neonatal intensive care birthweight babies without increase in abdominal
units or special care nurseries. At least one person deliveries suggested that cesarean sections were
from all three university hospitals and all general unnecessary in preterm deliveries. Clinical
hospitals, 89.3% (92/103) of the district hospitals, monitoring of asphyxiated newborns was adequate
3.5% (73/2,090) of the maternal and child health enough.
services, and 21% (46/219) of the private hospitals
220
Debillon, T., P. Daoud, P. Durand, S. Cantagrel, P. life thus emphasizing the need for vigorous
Jouvet, C. Saizou, and V. Zupan. 2003. management of asphyxiated babies at birth.
“Whole-body cooling after perinatal asphyxia: a
pilot study in term neonates,” Dev. Med. Child
Neurol., vol. 45, no. 1, pp. 17–23. Deorari, A. K., V. K. Paul, M. Singh, and D.
Vidyasagar. 2001. “Impact of education and
Abstract: In order to test the practicability and training on neonatal resuscitation practices in
safety of whole-body cooling in term neonates with 14 teaching hospitals in India,” Ann. Trop.
moderate-to-severe hypoxic-ischaemic Paediatr., vol. 21, no. 1, pp. 29–33.
encephalopathy (HIE) and to report outcomes, a
prospective pilot study was carried out in 25 term Abstract: The impact of a neonatal resuscitation
infants (median postmenstrual age 38 weeks, range program (NRP) on the incidence, management and
36 to 41 weeks; 20 males, 5 females). Whole-body outcome of birth asphyxia was evaluated in
cooling, to a target core temperature of 33°C to 14 teaching hospitals in India. Two faculty
34°C, started within six hours of birth and was members from each institution attended a neonatal
maintained for 72 hours. Of the 25 newborn resuscitation certification course and afterwards
infants (19 Sarnat II and six Sarnat III, 18 trained staff in their respective hospitals. Each
outborn), 18 survived, including 13 (72%) with institution provided three months pre-intervention
normal cerebral signal by MRI. Temperature and 12 months post-intervention data. Introduction
instability occurred during cooling in 15 infants, of the NRP significantly increased awareness and
but neither severe hemodynamic instability nor documentation of birth asphyxia, as judged by an
renal failure was seen. Thrombocytopenia increased incidence of asphyxia based on apnea or
developed in 12 infants, including seven with gasping at 1 and 5 minutes (p<0.001 and <0.01,
biological disseminated intravascular coagulation. respectively). A significant shift towards more
One patient had hypoxaemia with right-to-left rational resuscitation practices was indicated by a
shunting through the ductus arteriosus, and seven decline in the use of chest compression and
had limited meningeal or subdural bleeding. medication (p<0.001 for each), and an increase in
Whole-body cooling is feasible in term neonates, the use of bag and mask ventilation (p<0.001).
with no life-threatening adverse events. Although overall neonatal mortality did not
Improvements are needed to obtain stable decrease, asphyxia-related deaths declined
hypothermia for 72 hours. significantly (p<0.01).
Deorari, A. K., V. K. Paul, and M. Singh. 1989. Deorari, A. K., V. K. Paul, M. Singh, and D.
“Birth asphyxia and neurodevelopmental Vidyasagar. 2000. “The National Movement of
outcome,” Indian Pediatr., vol. 26, no. 8, Neonatal Resuscitation in India,” J. Trop.
pp. 793–799. Pediatr., vol. 46, no. 5, pp. 315–317.
Abstract: Thirty-six neonates with severe birth Abstract: Summary Birth asphyxia is an important
asphyxia (Apgar score less than or equal to 3 at 1 cause of preventable neonatal morbidity and
minute), 32 with moderate birth asphyxia (Apgar mortality in developing countries. Of the
score 4 to 6 at 1 minute) and 35 controls (Apgar 26 million births each year in India, 4%–6% of
221
of the country. The certified faculty members in Finer, N. N. and W. Rich. 2002. “Neonatal
turn trained 12,000 healthcare professionals in resuscitation: toward improved performance,”
various parts of India over the following two years. Resuscitation, vol. 53, no. 1, pp. 47–51.
Simultaneously, in several teaching institutions,
Abstract: BACKGROUND: As part of a
NRP was introduced into the curricula of medical
continuous quality assurance process which we
and nursing students. This program provides a
instituted in 1999, we review videotapes of selected
uniform, systematic and action-oriented approach
high-risk deliveries at our hospital. We utilized our
to the resuscitation of the newborn. Prospective
reviews to evaluate the occurrence of errors, and to
evaluation of the resuscitation program in teaching
evaluate team and leader functions during neonatal
hospitals has revealed the use of rational
resuscitation. METHODS: We established accepted
resuscitation practices and a significant decline in
behavior for members of resuscitation teams and
asphyxia-related deaths.
the team leader. The actual conduct of the
resuscitation was judged against the standard of
Ellis, M., D. S. Manandhar, N. Manandhar, J. the guidelines of the Neonatal Resuscitations
Wyatt, A. J. Bolam, and A. M. Costello. 2000. Program of the American Heart Association, and
“Stillbirths and neonatal encephalopathy in the American Academy of Pediatrics. The
Kathmandu, Nepal: an estimate of the videotapes of resuscitations were reviewed, and
contribution of birth asphyxia to perinatal significant deviations from accepted practices were
mortality in a low-income urban population,” noted, and discussed by a specifically developed
Paediatr. Perinat. Epidemiol., vol. 14, no. 1, quality assurance committee, including, whenever
pp. 39–52. possible, the actual resuscitators. RESULTS: We
were able to detect a number of problems, which
Abstract: We describe a prospective cross-sectional included inappropriate leader and team member
survey over a 12-month period in the principal activities, inappropriate preparation,
maternity hospital of Kathmandu, Nepal, where communication, and coordination, and made a
over 50% of the local population deliver. The number of changes to our practice.
study aim was to estimate the contribution of CONCLUSIONS: We believe that neonatal
birth asphyxia to perinatal mortality in this resuscitation may be improved by the provision of
setting. During 1995, there were 14,371 livebirths teaching about team and leader functions,
and 400 stillbirths, a total stillbirth rate of 27 per encouraging debriefing following complicated
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
1,000 total births. The fresh term (2,000g or resuscitations, developing a minimal form to be
more) stillbirth rate was 8.5 per 1,000 total births completed for any patient requiring compressions
[95% CI: 7.1, 10.1]. Ninety-two cases of neonatal or epinephrine within the delivery room, and
encephalopathy (NE) affecting term infants were providing more direct observations regarding the
detected (excluding those due to congenital actual conduct of resuscitation.
malformations, hypoglycemia and early neonatal
sepsis). The birth prevalence of NE was 6.4 per
1,000 livebirths [95% CI: 5.2, 7.8]. There was Frey, B. and F. Shann. 2003. “Oxygen
evidence of intrapartum compromise in 63 (68%) administration in infants,” Arch. Dis. Child
of the cases of NE and 65 (76%) of the stillbirths, Fetal Neonatal Ed, vol. 88, no. 2, pp. F84–F88.
but only in 12 (12%) of controls. The cause-
Abstract: The main methods of oxygen
specific early neonatal mortality rate for NE was
administration to infants are reviewed. Some
2.1 per 1,000 livebirths [95% CI: 1.4, 3.0].
methods are more economical and therefore more
Combining the NE deaths and fresh stillbirths
useful in developing countries. All the methods
gives an upper estimate for term birth asphyxia
have potential complications and therefore need to
perinatal mortality rate of 10.8 per 1,000 total
be carefully supervised.
births [95% CI: 9.2, 12.6], 24% of all perinatal
deaths before hospital discharge. This study
suggests that birth asphyxia remains an important Gonzalez, d. D., M. Moya, and J. Vioque. 2001.
cause of perinatal mortality in developing “Risk factors predictive of neurological sequelae
countries. The paper discusses the pros and cons in term newborn infants with perinatal
of different strategies to reduce birth asphyxia in asphyxia,” Rev. Neurol., vol. 32, no. 3,
low-income countries. pp. 210–216.
222
Abstract: INTRODUCTION: Perinatal asphyxia outcome. Clinical and experimental studies have
(PA) and its neurologic manifestations are the most now shown that hypoxic-ischemic injury continues
important cause of brain injury and neurologic to evolve after resuscitation. Experimentally,
sequelae in full-term infants. The objective of this prolonged mild to moderate hypothermia can
study is to analyze the perinatal risk factors of dramatically reduce this delayed injury, while mild
neurologic sequelae in asphyctic term newborns. hyperthermia over the same period worsens injury.
PATIENTS AND METHODS: One hundred and Indeed there are data indicating that moderate
fifty-six consecutive asphyctic term infants were post-ischemic hyperthermia can be deleterious as
studied prospectively during 40 months. PA was late as 24 hours after reperfusion. Hypothermia
graded in two stages (severe and non-severe), has significant potential adverse effects, and at
hypoxic-ischemic encephalopathy classification was present its clinical use is restricted to large
based on Levene’s criteria, and neurologic sequelae randomized controlled trials. The present paper
was based on Finer and Amiel-Tisson’s criteria. The reviews evidence suggesting that both primary
perinatal variables were graded as prenatal prevention of maternal pyrexia during labor, and
(gestational and obstetrics), neonatal (resuscitation, secondary prevention of hyperthermia after
general data of the newborn, and organic neonatal resuscitation, have the potential to
manifestations of asphyxia) and postneonatal significantly reduce the consequences of perinatal
(neurologic sequelae with at least 24 months of hypoxia-ischemia
follow-up). The relationships between these
variables are studied by univariant and
multivariant analysis (Cox’s regression). RESULTS: Ho, N. K. 2001. “Decision-making: initiation and
PA was graded as severe in 31 cases and non-severe withdrawing life support in the asphyxiated
in 125. Neurologic manifestations (hypoxic- infants in developing countries,” Singapore
ischemic encephalopathy) during neonatal period Med. J., vol. 42, no. 9, pp. 402–405.
were present in 25.6%, and extraneurologic Abstract: The issues of life support in the
manifestations (hypoxic-ischemic disease) in asphyxiated infant are not only whether
41.7% cases. The incidence of neurologic sequelae, cardiopulmonary resuscitation or CPR will be
in 115 asphyxiated full-term infants follow-up at successful, but also whether if successful, the infant
least 24 months, was 16.5% (19 cases). The will be severely damaged. This is particularly
perinatal variables associated to risk of neurologic important in the developing countries because the
sequelae on univariate analysis are variables of damaged infants may burden the society.The
neonatal resuscitation (1-minute Apgar score country has to allocate huge financial and human
< or = 4, 5-minute Apgar score < or = 6, resources to look after them. When it comes to
endotracheal intubation, severity of PA) and decisions in initiation and withdrawal of life
variables of systemic manifestations (hypoxic- support, there are differences between the East and
ischemic encephalopathy, cardiovascular and multi- the West. Physicians are searching for reliable
systemic dysfunction, and mechanical ventilation). predictors of outcome of term asphyxiated infants
But only two variables are independently to enable early decision-making, initiation and
associated on multivariate analysis: severe PA withdrawal life support, as well as counseling and
(RR=2.82; CI: 1.07–7.39) and hypoxic-ischemic planning appropriate level of treatment including
encephalopathy (RR=4.17; CI: 1.48–11.75). trials of cerebroprotective therapies. Markers
223
withdrawing life support of the severely Kaye, D. 2003. “Antenatal and intrapartum risk
asphyxiated infants, one must be aware of the factors for birth asphyxia among emergency
differences of approach. There are differences in obstetric referrals in Mulago Hospital,
religion and culture; in beliefs and philosophies, Kampala, Uganda,” East Afr. Med. J., vol. 80,
between the East and West The importance of no. 3, pp. 140–143.
neonatal resuscitation should be emphasized. Some
Abstract: BACKGROUND: Many perinatal deaths
regions still adhere to obsolete resuscitation
follow birth asphyxia that occurs in newborn babies
methods. Neonatal Resuscitation Program (NRP)
of women who are referred on developing life-
should be promulgated and organized resuscitation
threatening obstetric complications. OBJECTIVE:
should be introduced. There is an urgent need to
To determine the antenatal and intrapartum risk
train the trainers in CPR in the developing
factors for severe birth asphyxia among babies
countries.
delivered by women admitted as emergency
obstetric referrals. DESIGN: Case-control study.
Hoskyns, E. W., A. D. Milner, and I. E. Hopkin. SETTING: Mulago hospital, the National Referral
1987. “A simple method of face mask Hospital, Kampala, Uganda. SUBJECTS: Cases
resuscitation at birth,” Arch. Dis. Child, were newborn term babies (and their mothers) with
vol. 62, no. 4, pp. 376–378. a 5-minute Apgar score 4 or less (birth asphyxia).
Controls were term newborn babies with a
Abstract: Twenty two infants were resuscitated at 5-minute Apgar score more than four. MAIN
birth using a face mask connected to an oxygen OUTCOME MEASURES: Antepartum and
supply from a conventional resuscitaire. intrapartum risk factors among newborn babies
Intermittent finger occlusion provided the positive (and their mothers) from socio-demographic
pressure within the mask. This method was characteristics, obstetric complications or labor
apparently at least as effective as the best bag and management. The Odds ratios (OR) for various
mask systems and was convenient to use. outcomes were calculated using the Statistical
Assistance Software (SAS) version 6.2 (Windows),
Kamenir, S. A. 1997. “Neonatal resuscitation and and are presented with their 95% confidence
newborn outcomes in rural Kenya,” J. Trop. intervals (CIs) and p-values. RESULTS: There was
Pediatr., vol. 43, no. 3, pp. 170–173. no association between socio-demographic factors
and birth asphyxia. Antepartum hospitalization,
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
224
Abstract: Very scanty information is available in extent of the problem of birth asphyxia. Births and
East, Central and Southern Africa on the incidence neonatal deaths were recorded in 54 villages.
and risk factors associated with asphyxia of the Trained field workers contacted birth
newborn. A multicenter prospective study involving attendants/family members within 15 days after the
4,267 deliveries in eight countries was undertaken birth, and recorded the symptoms and signs related
over a three month period, in maternity units of to birth asphyxia on a pre-coded questionnaire.
the central hospitals to determine the incidence; Detailed descriptive history of birth events in
maternal, service and logistic risk factors for chronological order was recorded in cases
asphyxia of the newborn as determined by an suspected to be asphyxiated or stillborn. Two
abnormally low apgar score. Thirty percent of pediatricians reviewed the case histories
births were by primigravida mothers, of whom independently to assign the diagnosis. Out of the
67% were teenagers. A birth by a teenager had a 1,977 recorded live births, field workers suspected
higher risk for low birthweight. Overall incidence 53 babies to be asphyxiated, 39 of these were
of low birthweight was 13.9%. The overall diagnosed as asphyxiated, four as not asphyxiated
incidence of asphyxia of the newborn was by both the experts, and 10 were considered as
22.9% while that associated with low birthweight asphyxiated by one of the experts. Prevalence of
(i.e., babies weighing less than 2,500 grams) was birth asphyxia was estimated to be at least
29.3% compared with 21.5% among the normal 2% (39/1,977). Case fatality in these cases was
birthweight babies. Low birthweight contributed a 74%. The verbal diagnosis method adopted in this
large proportion of the high neonatal mortality of study can be used to compare the prevalence of
15.9% compared to 1.8% for normal birthweight asphyxia in community studies.
babies by 24 hours after birth. The mean mortality
by 24 hours post delivery was 3.8%. Obstetrical
complications are important risk factors for Levene, M. I., C. Sands, H. Grindulis, and J. R.
asphyxia of the newborn. Among the important Moore. 1986, “Comparison of two methods of
risk factors are those associated with prolonged predicting outcome in perinatal asphyxia,”
labor and intra partum accidents. The incidence of Lancet, vol. 1, no. 8472, pp. 67–69.
risk for asphyxia broadly was 21.3%, which is Abstract: In a follow-up study of 122 full-term
very close to the actual incidence of asphyxia of infants in whom postasphyxial encephalopathy
22%. Lack of referral contributed to increased risk occurred the incidence of death or severe handicap
of asphyxia. In a significant proportion of infants, was one in 1,000 deliveries. The abilities of two
resuscitation measures taken were inappropriate. methods of diagnosing intrapartum asphyxia to
The stillbirth rate was 3.0% while the incidence of predict outcome at a median age of 2.5 years were
externally evident congenital malformations was compared. A decision matrix calculation was
1.2%. There is urgent need to institute appropriate undertaken to assess the sensitivity and specificity
measures to prevent and manage asphyxia of the of low Apgar score and postasphyxial
newborn in the region. These should include encephalopathy. A 10-minute Apgar score less than
identification of the at risk mother, proper referral or equal to five was the most sensitive of six
and management while adhering to correct different Apgar ratings in predicting adverse
established procedures. There is also need to outcome (sensitivity 43%, specificity 95%) but
develop appropriate and relevant technologies for even this was much less sensitive than the presence
225
memory, perceptual-motor skills, and frontal lobe Although imperfect, it would seem a little
functions, because these are areas of cognitive premature to pension the Apgar score off yet.
functioning susceptible to hypoxic conditions.
RESULTS: Subjects with moderate PA showed
significant differences from the control group on Massawe, A., C. Kilewo, S. Irani, R. J. Verma, A.
tests related to delayed recall for both verbal and B. Chakrapam, T. Ribbe, R. Tunell, and B.
visual information, perceptual-motor speed, and Fischler. 1996. “Assessment of mouth-to-mask
tests assessing attention and executive functions. ventilation in resuscitation of asphyxic newborn
Conversely, subjects in the mild PA group exhibited babies. A pilot study,” Trop. Med. Int. Health,
scores which were similar to those of the control vol. 1, no. 6, pp. 865–873.
group in all the assessed variables. CONCLUSION: Abstract: The aim of the study was to compare the
The present findings demonstrate that subtle but effectiveness of mouth-to-mask ventilation (MM)
persistent neuropsychological deficits were in neonatal asphyxia with bag-and-mask
observed in adolescents with antecedents of ventilation (BM). A new mouth-to-mask infant
moderate PA, but not in those classified with mild resuscitation system was constructed. The study
asphyxia. was performed in two university clinics with
different resources. The KEM Hospital in Bombay
was well equipped and neonatologists took part in
Manzar, S. 2000. “Neonatal resuscitation: a report
all resuscitations; Muhimbili Medical Centre in
from Oman,” Trop. Doct., vol. 30, no. 3,
Dar es Salaam was understaffed and had no
pp. 164–165.
physicians available at resuscitation. Therefore,
Abstract: There has been a considerable increase in different protocols had to be used. In Bombay, the
the educational level and awareness of neonatal study period was limited to five minutes. If needed,
care in developing countries over last decade. The mask ventilation was then replaced by intubation.
importance of neonatal resuscitation, however, has In Dar es Salaam, MM ventilation was continued
been ignored. This report discusses the importance for up to 10 minutes, the inspiratory pressure was
of structured neonatal courses with emphasis on adjusted to 30cm H2O and the ventilation was
the need for more such courses at regional levels, slow (eight to ten breaths/min). In Bombay, 30
especially in developing countries. The concept of babies were allocated to the BM and 24 to the
basic and advanced life support of the newborn is MM groups. In Dar es Salaam 56 were in the BM
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
226
Milner, A. D., G. M. Stokes, R. Tunell, M. CO(2) detection can be useful in the secondary
McKeugh, and H. Martin. 1992. “Laboratory confirmation of endotracheal intubation.
assessment of Laerdal mouth tube mask ■ Chest compressions: Compressions should be
prototype resuscitation device,” Med. Biol. Eng administered if the heart rate is absent or
Comput., vol. 30, no. 1, pp. 117–119. remains <60 bpm despite adequate assisted
ventilation for 30 seconds. The two-thumb,
Abstract: The Laerdal prototype device is easy to
encircling-hands method of chest compression is
use, even by those with no previous resuscitation
preferred, with a depth of compression one
experience. The incorporation of a simple water
third the anterior-posterior diameter of the chest
manometer during training improves performance
and sufficient to generate a palpable pulse.
so that pressures generated are very similar to
■ Medications, volume expansion, and vascular
those recommended for routine endotracheal
access: Epinephrine in a dose of
resuscitation. Finally, a simple bag makes an
0.01–0.03 mg/kg (0.1–0.3 mL/kg of 1:10,000
entirely satisfactory substitute for an expensive
solution) should be administered if the heart
resuscitation manikin. In our opinion it is now
rate remains <60 bpm after a minimum of 30
appropriate for further studies to be carried out
seconds of adequate ventilation and chest
using the device in resuscitation of asphyxiated
compressions. Emergency volume expansion
newborn babies.
may be accomplished with an isotonic
crystalloid solution or O-negative red blood
Niermeyer, S., J. Kattwinkel, P. Van Reempts, V. cells; albumin-containing solutions are no longer
Nadkarni, B. Phillips, D. Zideman, et al. 2000. the fluid of choice for initial volume expansion.
“International guidelines for neonatal Intraosseous access can serve as an alternative
resuscitation: an excerpt from the Guidelines route for medications/volume expansion if
2000 for Cardiopulmonary Resuscitation and umbilical or other direct venous access is not
Emergency Cardiovascular Care: International readily available.
Consensus on Science. Contributors and ■ Noninitiation and discontinuation of
Reviewers for the Neonatal Resuscitation resuscitation: There are circumstances (relating
Guidelines,” Pediatr., vol. 106, no. 3, p. E29. to gestational age, birthweight, known
underlying condition, lack of response to
Abstract: The International Guidelines 2000 interventions) in which noninitiation or
Conference on Cardiopulmonary Resuscitation discontinuation of resuscitation in the delivery
(CPR) and Emergency Cardiac Care (ECC) room may be appropriate.
formulated new evidenced-based recommendations
for neonatal resuscitation. These guidelines
comprehensively update the last recommendations, Niermeyer, S. and J. Perlman. 2001.
published in 1992 after the Fifth National “Pathophysiology of neonatal resuscitation:
Conference on CPR and ECC. As a result of the application in a global context,” Semin.
evidence evaluation process, significant changes Neonatol., vol. 6, no. 3, pp. 213–217.
occurred in the recommended management
Abstract: Despite the adoption of evidence-based
routines for:
guidelines for neonatal resuscitation, formulated
■ Meconium-stained amniotic fluid: If the newly with international consensus, the process of
227
information can be learned through comparison minute or 6 or less at 5 minutes) was collected
and evaluation of different techniques. In such a from the midwife and from the baby’s chart. Of the
way, the evidence base for neonatal resuscitation 97,648 live births, 1,633 (1.7%) had a low Apgar
can be strengthened and infants around the world score. The risk increased with decreasing
can share in the benefits realized. birthweight and with severe malformations. Before
delivery, 19% of the low-Apgar-score infants were
not expected to require resuscitation. Eighty
Niermeyer, S., P. Van Reempts, J. Kattwinkel, T. percent of the ventilated infants were satisfactorily
Wiswell, D. Burchfield, O. D. Saugstad, A. ventilated by bag and mask; the remainder were
Milner, S. Knaebel, J. Perlman, D. Azzopardi, intubated. Of the ventilated infants, 78%
A. Gunn, R. Boyle, S. Toce, and A. Solimano. developed spontaneous breathing within
2001. “Resuscitation of newborns,” Ann. 10 minutes after birth and 89% within 20 minutes.
Emerg. Med., vol. 37, no. 4 Suppl, Routine intubation or administration of buffer in
pp. S110–S125. cases of postnatal asphyxia had no influence on the
Abstract: This article summarizes guidelines and time to onset of regular spontaneous breathing.
newer information on various aspects of
resuscitation of newborns, including meconium-
Pschirrer, E. R. and E. R. Yeomans. 2000. “Does
stained amniotic fluid and direct endotracheal
asphyxia cause cerebral palsy?” Semin.
suctioning, use of room air versus 100% oxygen in
Perinatol., vol. 24, no. 3, pp. 215–220.
positive-pressure ventilation for distressed
newborns, acute volume expansion for significant Abstract: The incidence of cerebral palsy is one per
volume loss, cerebral hypothermia after perinatal 1,000, whereas the proportion caused by perinatal
asphyxia, and non-initiation and discontinuation of asphyxia is only 8% to 10%. The purpose of this
resuscitation in the delivery room. article is to review the relationship between
asphyxia and cerebral palsy. Only a minority of
cases, those involving severe pathological fetal
Palme, C., B. Nystrom, and R. Tunell. 1985. “An academia, are consistently associated with neonatal
evaluation of the efficiency of face masks in the encephalopathy and an increased risk of cerebral
resuscitation of newborn infants,” Lancet, palsy.
vol. 1, no. 8422, pp. 207–210.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
228
oxygen groups (p=0.59), and the time to first cry Saugstad, O. D., T. Rootwelt, and O. Aalen. 1998.
was 3.0 (2.0–4.0) minutes and 3.5 (2.5–5.5) “Resuscitation of asphyxiated newborn infants
minutes in the room air and oxygen groups, with room air or oxygen: an international
respectively (p=0.19). Three neonates in the room controlled trial: the Resair 2 study,” Pediatr.,
air group and four in the oxygen group died in the vol. 102, no. 1, p. e1.
neonatal period. At 28 days, 72 of the 77 surviving
Abstract: OBJECTIVE: Birth asphyxia represents a
neonates were available for follow-up (36 in each
serious problem worldwide, resulting in
group), and none had any neurologic sequelae.
approximately one million deaths and an equal
number of serious sequelae annually. It is therefore
Saugstad, O. D. 2001. “Resuscitation of the important to develop new and better ways to treat
asphyxic newborn infant: new insight leads to asphyxia. Resuscitation after birth asphyxia
new therapeutic possibilities,” Biol. Neonate, traditionally has been carried out with
vol. 79, no. 3-4, pp. 258–260. 100% oxygen, and most guidelines and textbooks
recommend this; however, the scientific
Abstract: The basic mechanisms leading to cell background for this has never been established. On
death in birth asphyxia are becoming better the contrary, theoretic considerations indicate that
known. Some of these are excitotoxicity, resuscitation with high oxygen concentrations
inflammation and oxidative stress. In the so-called could have detrimental effects. We have performed
therapeutic window—between the primary and a series of animal studies as well as one pilot study
secondary energy failure—modulation of these indicating that resuscitation can be performed with
processes may be beneficial, reducing apoptosis room air just as efficiently as with 100% oxygen.
and perhaps necrosis. In order to reduce oxidative To test this more thoroughly, we organized a
stress, reoxygenation with low oxygen multicenter study and hypothesized that room air is
concentrations, even as low as room air, might be superior to 100% oxygen when asphyxiated
beneficial. Increased oxidative stress might have newborn infants are resuscitated.
long-term effects on brain growth and development METHODOLOGY: In a prospective, international,
and there is evidence indicating that exposure to controlled multicenter study including 11 centers
100% oxygen after birth for only a few minutes from six countries, asphyxiated newborn infants
might have long-term effects. New guidelines for with birthweight >999g were allocated to
newborn resuscitation have recently been published resuscitation with either room air or 100% oxygen.
but more research is needed in this field, especially The study was not blinded, and the patients were
regarding resuscitation of preterm infants, where allocated to one of the two treatment groups
few data exist. according to date of birth. Those born on even
dates were resuscitated with room air and those
Saugstad, O. D. 2001. “Resuscitation of newborn born on odd dates with 100% oxygen. Informed
infants with room air or oxygen,” Semin. consent was not obtained until after the initial
Neonatol., vol. 6, no. 3, pp. 233–239. resuscitation, an arrangement in agreement with
the new proposal of the U.S. Food and Drug
Abstract: Oxygen is a toxic agent and a critical Administration’s rules governing investigational
approach regarding its use during resuscitation at drugs and medical devices to permit clinical
229
30 minutes of age, and abnormal neurologic Abstract: Perinatal asphyxia associated with
examination at four weeks. The existing routines hypoxic-ischemic brain injury remains an
for resuscitation in each participating unit were important cause of long-term morbidity in both
followed, and the ventilation techniques described premature and term infants. Early, severe
by the American Heart Association were used as neurologic dysfunction appears to be the most
guidelines aiming at a frequency of manual useful indicator that a significant hypoxic-ischemic
ventilation of 40 to 60 breaths per minute. insult has occurred, and is the best predictor of
RESULTS: Forms for 703 enrolled infants from neurologic sequelae. There are distinct gestational
11 centers were received by the steering committee. age dependent differences in the vulnerability of
All 94 patients from one of the centers were specific cerebral structures to hypoxic-ischemic
excluded because of violation of the inclusion damage, which ultimately determines the type and
criteria in 86 of these. Therefore, the final number severity of neurologic sequelae. Both major and
of infants enrolled in the study was 609 minor handicapping conditions are seen, the latter
(from 10 centers), with 288 in the room air group having important consequences on later academic
and 321 in the oxygen group. Median achievement. Long-term, longitudinal follow-up is
(5 to 95 percentile) gestational ages were required for any asphyxiated infant with early
38 (32.0 to 42.0) and 38 (31.1 to 41.5) weeks intervention as the goal. As newer imaging
(NS), and birthweights were 2,600 (1,320 to modalities are employed and studied, we are
4,078)g and 2,560 (1,303 to 3,900)g (NS) in the learning more about the neuropathology of
room air and oxygen groups, respectively. There asphyxia and correlating it to outcome. However,
were 46% girls in the room air and 41% in the the ability to accurately predict long-term
oxygen group (NS). Mortality in the first seven neurodevelopmental outcome in seriously
days of life was 12.2% and 15.0% in the room air asphyxiated infants remains elusive.
and oxygen groups, respectively; adjusted odds
ratio (OR)=0.82 with 95% confidence intervals
(CI): 0.50–1.35. Neonatal mortality was Vento, M., M. Asensi, J. Sastre, F. Garcia-Sala, F.
13.9% and 19.0%; adjusted OR=0.72 with V. Pallardo, and J. Vina. 2001. “Resuscitation
95% CI: 0.45–1.15. Death within seven days of life with room air instead of 100% oxygen prevents
and/or moderate or severe hypoxic-ischemic oxidative stress in moderately asphyxiated term
encephalopathy (primary outcome measure) was neonates,” Pediatr., vol. 107, no. 4,
seen in 21.2% in the room air group and in pp. 642–647.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
230
resuscitated with 100% oxygen (1.2 +/– 0.6 fails). A final section outlines a series of actions at
minutes vs. 1.7 +/– 0.5 minutes). Moreover, the national and local levels to help health facilities
RAR group needed less time undergoing ventilation introduce or improve newborn resuscitation
to achieve a sustained respiratory pattern than the practices.
group resuscitated with pure oxygen (4.6 +/– 0.7
32 pp. English.
minutes vs. 7.5 +/– 1.8 minutes). The reduced-to-
oxidized-glutathione ratio, which is an accurate WHO/RHT/MSM/98.1/Order no. 1930124
index of oxidative stress, of the RAR group
(53 +/– 9) at 28 days of postnatal life showed no ORDERING INFORMATION: Document can be
differences with the control nonasphyxiated group ordered for Sw. fr. 10.00 / U.S. $9.00; in
(50 +/– 12). However, the reduced-to-oxidized- developing countries, for Sw.fr. 7.00 / U.S. $6.30,
glutathione ratio of the 100% oxygen-resuscitated using the online form at:
group (OxR) (15 +/– 5) was significantly lower and http://www.who.int/dsa/cat95/zhow.htm
revealed protracted oxidative stress. Furthermore, Or mail, fax, or email the request and order to:
the activities of superoxide dismutase and catalase World Health Organization, Distribution and Sales
in erythrocytes were 69% and 78% higher, CH-1211 Geneva 27
respectively, in the OxR group than in the control Switzerland
group at 28 days of postnatal life. Thus, this shows Fax: 41 22 791 48 57
that these antioxidant enzymes, although higher Email: bookorders@who.ch
than in controls, could not cope with the ongoing
generation of free radicals in the OxR group. Wiswell, T. E. 2003. “Neonatal resuscitation,”
However, there were no differences in antioxidant Respir. Care, vol. 48, no. 3, pp. 288–295.
enzyme activities between the RAR group and the
control group at this stage. CONCLUSIONS: Abstract: Ten million or more newborns worldwide
There are no apparent clinical disadvantages in each year need some type of resuscitation
using room air for ventilation of asphyxiated assistance. More than one million babies die
neonates rather than 100% oxygen. Furthermore, annually from complications of birth asphyxia.
RAR infants recover more quickly as assessed by Over the past three decades, neonatal resuscitation
Apgar scores, time to the first cry, and the has evolved from disparate, word-of-mouth
sustained pattern of respiration. In addition, teaching methods to organized programs. The most
neonates resuscitated with 100% oxygen exhibit widely-used curriculum is the Neonatal
biochemical findings reflecting prolonged oxidative Resuscitation Program, which is supported by the
stress present even after four weeks of postnatal American Academy of Pediatrics and the American
life, which do not appear in the RAR group. Thus, Heart Association. To date more than 1.5 million
the current accepted recommendations for using individuals have been trained in the Neonatal
100% oxygen in the resuscitation of asphyxiated Resuscitation Program. Resuscitation efforts are
newborn infants should be further discussed and geared toward avoiding or mitigating the adverse
investigated. sequelae of asphyxia neonatorum. Certain
characteristics distinguish the preterm infant,
including propensity to become hypothermic and
World Health Organization. 1998. Basic newborn higher potential for adverse neurologic and
places where TR is still being widely practiced Pediatric Research from 1993 to 2002.
especially in developing countries. SELECTION CRITERIA: randomized and quasi-
randomized controlled trials of newborns, both
preterm and term, receiving epinephrine for
Ziino, A. J., M. W. Davies, and P. G. Davis. 2003. unexpected apparent stillbirth or extreme
“Epinephrine for the resuscitation of apparently bradycardia. DATA COLLECTION AND
stillborn or extremely bradycardic newborn ANALYSIS: No studies were found meeting the
infants (Cochrane Review),” Cochrane. criteria for inclusion in this review MAIN
Database. Syst. Rev., no. 2, p. CD003849. RESULTS: No studies were found meeting the
criteria for inclusion in this review. REVIEWER’S
Abstract: BACKGROUND: Epinephrine is a
CONCLUSIONS: We found no randomized,
cardiac stimulant with complex effects on the heart
controlled trials evaluating the administration of
and blood vessels. It has been used for decades in
epinephrine to the apparently stillborn or
all age groups to treat cardiac arrest and
extremely bradycardic newborn infant. Similarly,
bradycardia. Despite formal guidelines for the use
we found no randomized, controlled trials which
of epinephrine in neonatal resuscitation, the
addressed the issues of optimum dosage and route
evidence for these recommendations has not yet
of administration of epinephrine. Current
been rigorously scrutinized. While it is understood
recommendations for the use of epinephrine in
that this evidence is in large part derived from
newborn infants are based only on evidence
animal models and the adult human population,
derived from animal models and the human adult
the contribution from work in the neonatal
literature. randomized trials in neonates are
population remains unclear. In particular, it
urgently required to determine the role of
remains to be determined if any randomized studies
epinephrine in this population.
in neonates have helped to establish if the
administration of epinephrine in the context of
apparent stillbirth or extreme bradycardia might
influence mortality and morbidity.
232
Neonatal Jaundice
233
or if the bilirubin oxidase system has been They included 56 cases (Group I) who had received
compromised by preceding birth asphyxia or other phototherapy for indirect hyperbilirubinemia in the
forms of central nervous system injury. early neonatal period. Thirty-two of these had, in
addition, undergone exchange transfusion. These
were compared with 56 controls (Group II)
Dennery, P. A., W. D. Rhine, and D. K. Stevenson. matched for age, sex, and birthweight. Only full
1995. “Neonatal jaundice—what now?,” Clin. term infants with normal intrauterine growth who
Pediatr. (Phila.), vol. 34, no. 2, pp. 103–107. had had an uneventful early neonatal period,
Abstract: Bilirubin has long been considered a foe. barring hyperbilirubinemia in Group I were taken
However, recent suggestions indicate that we have up for study. There was no difference in the socio-
been overly aggressive at combating this economic and educational status. Detailed
compound. Nonetheless, there are still many ophthalmalogical evaluation including tests for
questions regarding its absolute safety—at any visual acuity, dyslexia tests, and retinoscopic and
level—especially in association with conditions funduscopic examination did not reveal any
such as hemolytic disease, sepsis, or prematurity. significant differences between the two groups.
We therefore must approach high bilirubin levels
with continued caution until we have better
Linn, S., S. C. Schoenbaum, R. R. Monson, B.
answers to our questions. Let us remember that
Rosner, P. G. Stubblefield, and K. J. Ryan.
treatment for hyperbilirubinemia (i.e.,
1985. “Epidemiology of neonatal
phototherapy) is very safe. Is it not better to be
hyperbilirubinemia,” Pediatrics, vol. 75, no. 4,
safe than sorry?
pp. 770–774.
Abstract: Interview and record review data from
Gourley, G. R. 2002. “Breast-feeding, neonatal 12,023 singleton deliveries were analyzed to
jaundice and kernicterus,” Semin. Neonatol., determine the relationships between neonatal
vol. 7, no. 2, pp. 135–141. hyperbilirubinemia (10mg/dL or greater) and
Abstract: Despite the many advantages of maternal characteristics. Confounding variables
breastfeeding, there is ample documentation of the were controlled by multiple logistic regression
strong association between breastfeeding and an analysis. There was a statistically significant
increase in the risk of neonatal positive relationship between hyperbilirubinemia
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
hyperbilirubinaemia. Breastfed infants have higher and low birthweight, Oriental race, premature
bilirubin levels than formula-fed infants. Suggested rupture of membranes, breastfeeding, neonatal
mechanisms for these findings include poor fluid infection, use of the “pill” at time of conception,
and caloric intake, inhibition of hepatic excretion instrumental delivery, and history of first trimester
of bilirubin, and intestinal absorption of bilirubin bleeding. Maternal smoking and black race were
(enterohepatic circulation). On rare occasions, negatively related to hyperbilirubinemia and
breastfed infants without evidence of hemolysis statistically significant. In this study, other
have developed extreme hyperbilirubinaemia and previously suspected etiologic factors such as
kernicterus. Because almost all of the cases of epidural anesthesia, parity, use of oxytocin in labor,
kernicterus reported in the last 15 years have and white race were not associated with
occurred in fully or partially breastfed newborns, it hyperbilirubinemia.
is important that these infants be followed closely.
Appropriate support and advice must be provided
Madlon-Kay, D. J. 1997. “Recognition of the
to the lactating mother so that successful
presence and severity of newborn jaundice by
breastfeeding can be established and the risk of
parents, nurses, physicians, and icterometer,”
severe hyperbilirubinaemia reduced.
Pediatr., vol. 100, no. 3, p. E3.
Abstract: OBJECTIVE: To determine how well
Khanna, V. K., D. K. Mehta, M. Matthews, and I. parents, nurses, physicians, and an Ingram
Narayanan. 1984. “Neonatal icterometer can detect the presence and the severity
Hyperbilirubinemia: Ophthalmological of jaundice in newborns. SETTING: Normal
Evaluation of Term Infants Treated with newborn nursery in a 340-bed teaching hospital.
Phototherapy,” Indian Pediatrics, vol. 21, PATIENTS OR OTHER PARTICIPANTS: Nurses
p. 713. and physicians caring for nursery infants and
Abstract: This study comprises of 112 children parents of the infants. INTERVENTIONS:
ranging from six months to seven years of age. Physicians and nurses examining newborns
234
documented whether they detected jaundice in the bilirubin levels, adjusted mean IQs were 105.0 and
infants and, if so, the estimated bilirubin level and 103.4 in whites (difference + 1.6; 95% confidence
the extent of cephalocaudal progression of the interval [CI]: –0.4 to +3.5) and 91.0 and 93.3 in
jaundice. An assistant taught the parents how to blacks (difference –2.3; 95% CI: –4.8 to +0.2).
examine the infants for jaundice and determine its Abnormal neurologic examination results were
cephalocaudal progression. The assistant also reported in 12 of 268 children (4.5%) with
obtained icterometer readings. Bilirubin testing was bilirubin > or = 342mumol/L (20mg/dL) compared
performed according to usual clinical practice. with 1,249 of 33,004 children (3.8%) with lower
OUTCOME MEASURES: Nurse and physician levels (relative risk [RR]=1.2; 95% CI: 0.7 to 2.1).
estimates of bilirubin levels; parent, nurse, and The frequency of abnormal or suspicious
physician assessment of the presence of jaundice neurologic examination results increased in a
and its cephalocaudal progression; icterometer stepwise fashion with increasing bilirubin level
readings; bilirubin levels. RESULTS: There was (P<.001), from 4,346/29,258 (14.9%) of those
moderate agreement about the presence of jaundice with bilirubin levels <171mumol/L (10mg/dL) to
in the infants (pairwise kappa, 0.48) However, all 60/268 (22.4%) of those with bilirubin levels > or
infants with bilirubin levels >12mg/dL were = 342mumol/L (20mg/dL), apparently due to
correctly identified as jaundiced by all examiners. increasing minor motor abnormalities at higher
The parents’ assessment of cephalocaudal bilirubin levels. Sensorineural hearing loss was not
progression and the icterometer readings were most associated with high bilirubin levels (RR=1.0; 95%
highly correlated with serum bilirubin levels CI: 0.3 to 3.0). CONCLUSIONS: Neonatal
(adjusted Pearson correlations, 0.71 and 0.57, bilirubin levels seem to have little effect on IQ,
respectively). CONCLUSIONS: Many parents can definite neurologic abnormalities, or hearing loss.
be taught to accurately assess cephalocaudal Higher bilirubin levels are associated with minor
progression of jaundice in the hospital. The motor abnormalities, but the clinical importance of
icterometer is a useful tool for assessing jaundice this finding is limited by the weakness of the
severity. Both parent assessment and the association, the mild nature of the abnormalities,
icterometer were more highly correlated with and the lack of evidence that they are prevented by
bilirubin levels than physician and nurse estimates treatment.
in this study. Additional research is needed to
determine how accurate these methods of clinical
assessment are at the higher bilirubin levels that Newman, T. B., M. J. Easterling, E. S. Goldman,
typically occur after hospital discharge. and D. K. Stevenson. 1990. “Laboratory
evaluation of jaundice in newborns. Frequency,
cost, and yield,” Am. J. Dis. Child, vol. 144,
Newman, T. B. and M. A. Klebanoff. 1993. no. 3, pp. 364–368.
“Neonatal hyperbilirubinemia and long-term
Abstract: Neonates with hyperbilirubinemia
outcome: another look at the Collaborative
commonly undergo a battery of laboratory tests.
Perinatal Project,” Pediatrics, vol. 92, no. 5,
We used a computerized database and medical
pp. 651–657.
records to study the frequency, cost, and yield of
Abstract: OBJECTIVE: To examine the association these tests in 2,443 infants born at the University
between neonatal bilirubin levels and subsequent of California, San Francisco, between 1980 and
neurodevelopmental outcome. DESIGN: 1982. Four hundred forty-seven (18%) of the
Prospective cohort study. SETTING: Twelve U.S. infants met standard criteria for “nonphysiologic”
medical centers from 1959 (first births) to 1974 hyperbilirubinemia; the incidence varied from 9%
(last follow-up). PARTICIPANTS. 41,324 singleton in blacks to 31% in Asian infants. About 55% of
white or black infants with birthweight > or = these 447 infants received a $125
2,500g who had neonatal bilirubin measurements “hyperbilirubinemia workup.” Hospital discharge
recorded and survived at least one year. MAIN diagnoses on all 447 hyperbilirubinemic infants
NEONATAL JAUNDICE
OUTCOME MEASURES: Wechsler Intelligence were reviewed. In 214 (48%), no cause of the
Scale for Children Intelligence Quotient (IQ) at age jaundice was identified. An additional 145 (32%)
7 years, blinded neurologic examination at age 7 had a possible cause apparent from history,
years, and sensorineural hearing loss at age 8 years. physical examination, or initial hematocrit
RESULTS: There was no association between IQ determination. The only diagnosis made as a result
and bilirubin. For example, comparing children of routine investigations of hyperbilirubinemia was
who had maximum bilirubin levels > or = possible ABO or Rh isoimmunization in 75 infants
342mumol/L (20mg/dL) with those who had lower (17%). Nonphysiologic hyperbilirubinemia may be
235
more common than previously reported. The (9.74 +/– 3.17ml/dl) than those on formula
recommended tests are expensive and rarely lead to (6.59 +/– 3.50mg/dl), t=3.69, p<0.001), but did not
diagnoses other than ABO or Rh isoimmunization. reach any critical evels preparing phototherpy.
Their routine use should be reevaluated.
Narayanan, I., J. Banwalikar, R. Mehta, M.
Newman, T. B. and M. J. Maisels. 2000. “Less Ghorpade, M. R. Peesay, S. Nanda, and H. N.
aggressive treatment of neonatal jaundice and Seth. 1990. “A simple method of evaluation of
reports of kernicterus: lessons about practice jaundice in the newborn,” Ann. Trop. Paediatr.,
guidelines,” Pediatr., vol. 105, no. 1 Pt 3, vol. 10, no. 1, pp. 31–34.
pp. 242–245.
Abstract: This paper evaluates a simple tool, the
Abstract: The publication of guidelines calling for icterometer, in assessing jaundice in the newborn.
less aggressive treatment of jaundice in newborns The instrument consists of a perspex scale with
has been followed by a reappearance of case yellow stripes of increasing intensity, numbered one
reports of kernicterus. These case reports illustrate to five, alternating with transparent areas through
important issues for writers and consumers of which the infant’s blanched skin colour can be seen
practice guidelines. One issue is the particular and compared with the colored stripes. The scale
salience of identified patients with bad outcomes, was found to be useful for more objective screening
and their potentially disproportionate influence on of neonatal jaundice, particularly in decreasing the
decision-makers. A second issue is whether, when number of blood samples to be taken for serum
good evidence of treatment benefit is lacking, bilirubin. The present study suggests that serum
policymakers should recommend what has bilirubin estimation can be avoided when the
traditionally been done, recommend less treatment, icterometer readings on the face are 3 or less,
or not make recommendations at all. Finally, the unless there is a rapid rise in jaundice within
cases raise the question of whether treatment 24–36 hours. However, a reading on the sole of
guidelines should be more conservative than their even one is significant and requires assessment by
authors actually believe is necessary, to take into trained staff for blood sampling and/or
account the likelihood that they will not be closely phototherapy. The instrument may also be useful to
followed. We believe that case reports can serve as peripheral staff in developing countries when
an important early warning system, but deciding on referral to specialist centers and to
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
policymakers should be aware of their potentially staff in specialist centers for screening cases of
disproportionate influence. In the long run, neonatal jaundice and decreasing the number of
patients and clinicians will be best served by blood samples.
guidelines that summarize and acknowledge the
limitations of existing evidence, that allow a wide
range of treatment options when evidence is weak, Porter, M. L. and B. L. Dennis. 2002.
and that recommend what the guideline authors “Hyperbilirubinemia in the term newborn,”
actually believe should be done. In the short run a Am. Fam. Physician, vol. 65, no. 4,
period of readjustment may be required, however, pp. 599–606.
as clinicians become accustomed to guidelines Abstract: Hyperbilirubinemia is one of the most
written to be followed, rather than bent. common problems encountered in term newborns.
Historically, management guidelines were derived
from studies on bilirubin toxicity in infants with
Narayanan, I., A. Gupta, et al. 1987. “Infant
hemolytic disease. More recent recommendations
feeding and early neonatal jaundice,” Indian
support the use of less intensive therapy in healthy
Pediatr., vol. 54, pp. 257–260.
term newborns with jaundice. Phototherapy should
Abstract: The feeding patterns and third day serum be instituted when the total serum bilirubin level is
bilirubin levels were evaluated in 30 newborn at or above 15mg per dL (257 micromol per L) in
infants receiving formula feeds in the neonatal infants 25 to 48 hours old, 18mg per dL
special care unit and in 30 breastfed babies. (308 micromol per L) in infants 49 to 72 hours
Initiation of milk feeds were delayed in breastfed old, and 20mg per dL (342 micromol per L) in
babies and the frequency of feeding was infants older than 72 hours. Few term newborns
significantly lower than in the formula-fed infants. with hyperbilirubinemia have serious underlying
Supplementary water was given only in the pathology. Jaundice is considered pathologic if it
breastfed group. Serum bilirubin levels were presents within the first 24 hours after birth, the
significantly higher in breastfed infants total serum bilirubin level rises by more than
236
5mg per dL (86 micromol per L) per day or is Seidman, D. S., I. Paz, D. K. Stevenson, A. Laor, Y.
higher than 17mg per dL (290 micromol per L), or L. Danon, and R. Gale. 1991. “Neonatal
an infant has signs and symptoms suggestive of hyperbilirubinemia and physical and cognitive
serious illness. The management goals are to performance at 17 years of age,” Pediatr.,
exclude pathologic causes of hyperbilirubinemia vol. 88, no. 4, pp. 828–833.
and initiate treatment to prevent bilirubin
Abstract: To estimate the effect of neonatal
neurotoxicity.
hyperbilirubinemia on long-term cognitive ability
in full-term newborns with a negative Coombs test,
Riskin, A., M. Abend-Weinger, and D. Bader. we performed a 17-year historical prospective
2003. “How accurate are neonatologists in study of 1948 subjects. Intelligence tests and
identifying clinical jaundice in newborns?” medical examinations performed at the military
Clin. Pediatr. (Phila.), vol. 42, no. 2, draft board were stratified according to serum
pp. 153–158. bilirubin concentration. A logistic regression
analysis was used to adjust for the confounding
Abstract: This study reevaluates the clinical ability effects of gestational age, birthweight, Apgar score,
to accurately identify jaundice in neonates. Three ethnic origin, socioeconomic class, paternal
hundred seventy-one term infants were clinically education, birth order, and the administration of
assessed for jaundice, before discharge home on phototherapy and exchange transfusion. No direct
day 2 to 3 of life. Bilirubin levels obtained at the linear association was shown between neonatal
same time were significantly higher in the bilirubin levels and intelligence test scores or school
newborns clinically diagnosed as being jaundiced. achievement at 17 years of age. However, the risk
Our neonatologists were able to diagnose jaundice for low intelligence test scores (IQ score less than
at clinically low levels, and not to misdiagnose 85) was found to be significantly higher (P=.014)
significant hyperbilirubinemia in the majority of among full-term male subjects with serum bilirubin
the infants. The trained human eye can still levels above 342 mumol/L (20mg/dL) (odds ratio,
discriminate between the jaundiced and 2.96; 95% confidence interval, 1.29–6.79). This
nonjaundiced newborn, and clinical impression of association was not observed among female
jaundice remains a reliable primary screening tool subjects. We conclude that severe neonatal
for significant neonatal hyperbilirubinemia. hyperbilirubinemia, among full-term male
newborns with a negative Coombs test, could be
associated with lower IQ scores at 17 years of age.
NEONATAL JAUNDICE
237
Neonatal Hypoglycemia
Agrawal, R. K., K. Lui, and J. M. Gupta. 2000. Abstract: Among a cross-sectional sample
“Neonatal hypoglycaemia in infants of diabetic (stratified by weight and age after birth) of
mothers,” J. Paediatr. Child Health, vol. 36, 226 uncomplicated term newborns from the
no. 4, pp. 354–356. delivery and postnatal wards of a busy government
maternity hospital in Kathmandu, the period
Abstract: OBJECTIVE: To determine whether
prevalence of hypoglycemia (corrected blood
umbilical cord blood glucose correlates with
glucose of <2.6mmol/l) during the first 50 hours
subsequent hypoglycemia after birth in infants of
after birth was 38%. (This compares with a
well-controlled diabetic mothers.
reported prevalence rate of 12% from studies of
METHODOLOGY: Thirty-eight term infants of
uncomplicated term newborns in the UK.)
well-controlled diabetic mothers were enrolled.
Hypothermia, young maternal age, low birthweight
Five mothers had pre-existing diabetes. Of the
and early sampling after birth were independent
33 gestational diabetic mothers, 16 were managed
risk factors for hypoglycemia. Of 31 infants
on insulin and 17 on diet. Maternal blood glucose
studied longitudinally during the same period,
was maintained between four and eight mmol/L
27 (87%) had at least one blood glucose
during labor and delivery. Infants’ plasma glucose
measurement of <2.6mmol/l and 25 (81%) a rectal
levels were measured from venous cord blood and
temperature of <35.5°C. Fourteen infants (44%)
serially, at less than 30 minutes, 1 hour and
had three or more episodes of hypoglycemia and
2 hours of life by glucose hexokinase method.
seven infants (22%) had three or more episodes of
Blood glucose levels were further monitored by
hypothermia. Hypoglycemia is a common,
bedside Dextrostix for 24 hours. RESULTS:
preventable and neglected problem in many
Eighteen (47%) infants developed hypoglycemia
maternity hospitals in developing countries. Simple
(blood glucose level less than two mmol/L) during
low-cost measures to reduce the incidence of
the first 2 hours of life. There was no difference in
hypoglycemia may have a major impact on early
the cord blood glucose levels between infants with
infant mortality and neurodevelopmental sequelae
or without hypoglycemia (3.7 +/– 1.1 vs. 4.5 +/–
of perinatal origin.
1.1 mmol/L, respectively). Infants of mothers with
diabetes diagnosed prior to 28 weeks’ gestation
were at a higher risk of developing hypoglycemia Armentrout, D. and J. Caple. 1999. “Newborn
(8 of 10 vs. 10 of 28, OR=7.2, 95%CI: 1.3–40.7). hypoglycemia,” J. Pediatr. Health Care, vol. 13,
Hypoglycemic infants were of significantly higher no. 1, pp. 2–6.
birthweight, and were more likely to be born to
Caucasian mothers and by cesarean section. Raised Abstract: Neonatal hypoglycemia is a common
maternal fructosamine blood level, the need for problem encountered by both term and preterm
insulin treatment or the infant’s haematocrit were infants. It can be either symptomatic or
not different between infants with or without asymptomatic. Prolonged hypoglycemia may result
hypoglycemia. CONCLUSIONS: In well-controlled in permanent neurologic impairment and death.
diabetic mothers, the incidence of early Definitions of hypoglycemia vary and remain
hypoglycemia in infants is still high, particularly in controversial. Underlying causes of hypoglycemia
those mothers who had a longer duration of include (a) inadequate glucose production; (b)
diabetes. Cord blood glucose level did not identify increased glucose utilization; (c) abnormalities of
NEONATAL HYPOGLYCEMIA
the infants with hypoglycemia. endocrine regulation; and (d) other causes. Nurse
practitioners must be aware of infants at risk for
hypoglycemia so they can provide appropriate
Anderson, S., K. N. Shakya, L. N. Shrestha, and A. interventions. In this article the clinical
M. Costello. 1993. “Hypoglycaemia: a common characteristics of hypoglycemia are reviewed,
problem among uncomplicated newborn infants various causes for hypoglycemia are identified, and
in Nepal,” J. Trop. Pediatr., vol. 39, no. 5, an infant with prolonged hypoglycemia is
pp. 273–277. described. In addition, the role of the nurse
practitioner in the care and management of these
infants is addressed.
239
Bhat, M. A., P. Kumar, A. Bhansali, S. Majumdar, neurosciences, neonatal physiology and metabolism
and A. Narang. 2000. “Hypoglycemia in small that have occurred in Japan and around the world
for gestational age babies,” Indian J. Pediatr., throughout these three decades.
vol. 67, no. 6, pp. 423–427.
Abstract: The main objectives of the study were to Cornblath, M., J. M. Hawdon, A. F. Williams, A.
find the incidence and risk factors associated with Aynsley-Green, M. P. Ward-Platt, R. Schwartz,
development of hypoglycemia in small for and S. C. Kalhan. 2000. “Controversies
gestational age (SGA) babies, to compare regarding definition of neonatal hypoglycemia:
haemoglucotest strips (Boehringer Mannheim) with suggested operational thresholds,” Pediatr.,
the standard laboratory method (glucose- vol. 105, no. 5, pp. 1141–1145.
hexokinase) for estimation of blood glucose, and to
measure the insulin and cortisol responses of SGA Abstract: The definition of clinically significant
babies. This was a prospective longitudinal study. hypoglycemia remains one of the most confused
The sample included SGA babies and over a period and contentious issues in contemporary
of six months, 127 consecutively born small for neonatology. In this article, some of the reasons for
gestational age babies were investigated these contentions are discussed. Pragmatic
prospectively for development of hypoglycemia in recommendations for operational thresholds, i.e.,
first 48 hours of life. Plasma samples were taken blood glucose levels at which clinical interventions
during episodes of hypoglycemia for insulin and should be considered, are offered in light of current
cortisol estimation and compared with non- knowledge to aid health care providers in neonatal
hypoglycemic controls. The overall incidence of medicine. Future areas of research to resolve some
hypoglycemia was 25.2% in SGA babies and of these issues are also presented.
98% of the episodes occurred within first
24 hours. Compared to non-hypoglycemics, Eidelman, A. I. 2001. “Hypoglycemia and the
mothers of hypoglycemic babies had higher breastfed neonate,” Pediatr. Clin. North Am.,
incidence of receiving i.v. fluids (5% dextrose) vol. 48, no. 2, pp. 377–387.
during labor. The hypoglycemic babies were more
likely to be sick and oral feeds had been initiated Abstract: Healthy, full-term infants are functionally
by one hour of life in only 37% of them compared and metabolically programmed to make the
to 63% of non-hypoglycemic babies. Plasma transition from their intrauterine dependent
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
insulin/glucose ratio was significantly higher in environment to their extrauterine existence without
hypoglycemic than non-hypoglycemic babies, the need for metabolic monitoring or interference
whereas the cortisol levels were similar. Small for with the natural breastfeeding process. Full-term
gestational age babies are highly prone to develop infants are equipped with homeostatic mechanisms
hypoglycemia in first that preserve adequate energy substrate to the
24 hours of life. brain and other vital organs. Thermal stability and
early, properly guided, frequent, exclusive
breastfeeding are the keys to success. Thus, routine
Cornblath, M., H. Nakamura, R. Zetterstrom, and screening for blood glucose concentrations or
N. Kobayashi. 1997. “An international feeding sugar water is not necessary and potentially
symposium on neonatal hypoglycemia: thirty counterproductive to the establishment of a healthy
years later. Does it injure the neonatal brain?” mother-infant dyad.
Acta. Paediatr. Jpn., vol. 39 Suppl 1, pp. S1–S6.
Abstract: A discussion of neonatal hypoglycemia Ellis, M., D. S. Manandhar, N. Manandhar, J. M.
was held on 18 November 1995 as a satellite Land, N. Patel, and L. C. A. de. 1996,
symposium of the 40th Annual Meeting of Japan “Comparison of two cotside methods for the
Society for Premature and Newborn Medicine and detection of hypoglycaemia among neonates in
continued in closed session of 19 November to Nepal,” Arch. Dis. Child Fetal Neonatal Ed,
address neonatal hypoglycemia in the 21st century. vol. 75, no. 2, pp. F122–F125.
This represented a 30-year follow-up of a
discussion of carbohydrate and energy metabolism Abstract: OBJECTIVES: To compare two cotside
in the newborn held in Tokyo on 10 November methods of blood glucose measurement (HemoCue
1965. This follow-up was prompted by the and Reflolux II) against a standard laboratory
incredible advances in clinical care in perinatal method for the detection of neonatal hypoglycemia
medicine and in basic knowledge in the in a developing country maternity hospital where
240
hypoglycemia is common. METHODS: Ninety- healthy, term newborns. This results in the
four newborn infants and 75 of their mothers had misidentification of neonates captured while
blood glucose assessed on the same venous sample experiencing the normal, self-correcting physiologic
using three different methods in the Special Care blood glucose nadir who are then diagnosed with
Baby Unit and postnatal wards, Prasuti Griha pathologic neonatal hypoglycemia. Subsequent to
Maternity Hospital, Kathmandu, Nepal: HemoCue this misdiagnosis, further surveillance and
and Reflolux II at the cotside; Roche Ultimate unnecessary, aggressive treatment interventions will
glucose oxidase method (GOM) in the laboratory. follow that are potentially harmful to the successful
RESULTS: The mean (SD) values for blood glucose establishment of positive maternal-infant
in newborn infants were GOM 2.5 (1.1)mmol/l; interactions and the breastfeeding experience.
Reflolux II 2.1 (0.9); and HemoCue 4.2 (1.2). For Research studies indicate that routine
mothers the values were GOM 5.3 (1.2)mmol/l; hypoglycemia screens, treatments, and
Reflolux II 3.6 (1.2); and HemoCue 5.6 (1.0). interventions in the healthy infant are not evidence-
Bland-Altman plots showed that Reflolux II based and result in a serious disruption of the
consistently underreads GOM blood glucose in initiation process and duration patterns of
neonates by 0.5 mmol/l (SD 0.7) and that lactation. Using the perspective of the theory of
HemoCue overreads glucose by 1.7mmol/l (SD technology dependency, this inquiry explores the
0.8). For the detection of hypoglycemia potential adverse sequelae of inappropriate glucose
(<2.0mmol/l), Reflolux II achieved a sensitivity of screening in the healthy breastfeeding newborn and
83%, a specificity of 62%, and a likelihood ratio describes selected outcome variables including:
of 2.2. HemoCue produced a sensitivity of 0% and 1) the consequences of early maternal-infant
a specificity of 100% using measured values. If separation, 2) the influence of early formula
2.0 mmol were subtracted from all Hemocue supplementation on breastfeeding discontinuance
values this rose to 81% and 68% and a likelihood rates, 3) the effect of separation and
ratio of 2.5. CONCLUSION: Although more supplementation on the onset of lactogenesis, and
accurate than Reflolux II for the measurement of 4) the impact of hospital staff and provider
blood glucose in mothers, HemoCue overreads recommendations of formula supplementation on
glucose concentrations in neonates and is therefore maternal confidence to independently nurture her
potentially dangerous as a screening method for baby.
neonatal hypoglycemia. Reflolux II is useful as a
screening method for high risk infants (low
birthweight, post-term) and could achieve a post- Hawdon, J. M. 1999. “Hypoglycaemia and the
test probability of detecting hypoglycemia in a high neonatal brain,” Eur. J. Pediatr., vol. 158 Suppl
risk setting like Nepal of 50%–60%. 1, pp. S9–S12.
Abstract: There has been much controversy and
confusion regarding potential damage caused to the
Haninger, N. C. and C. L. Farley. 2001. “Screening
neonatal brain by low blood glucose levels.
for hypoglycemia in healthy term neonates:
Previous studies of outcome after neonatal
effects on breastfeeding,” J. Midwifery Womens
hypoglycemia are flawed by many factors including
Health, vol. 46, no. 5, pp. 292–301.
retrospective data collection and inability to
Abstract: Transient hypoglycemia in the early control for co-existing clinical complications. There
neonatal period is a common adaptive is no doubt that Hypoglycemic brain damage does
phenomenon as the newborn changes from the occur but the severity and duration of low blood
fetal state of continuous transplacental glucose glucose levels required to cause lasting harm varies
consumption to intermittent nutrient supply between subjects and is related to the ability of
NEONATAL HYPOGLYCEMIA
following cessation of maternal nutrition at birth. each baby to mount a protective response such as
Research has demonstrated that in the term, the production of ketone bodies which are
healthy newborn, this dynamic process is self- alternative cerebral fuels. Evidence from studies of
limiting and is not considered pathologic. The humans and other animals suggests that cortical
American Academy of Pediatrics and the World damage and long-term sequelae occur after
Health Organization recommend that neonatal prolonged hypoglycemia sufficiently severe to cause
blood glucose screening be reserved for newborns neurological signs. CONCLUSION: Prolonged
who are at risk or symptomatic and conclude that hypoglycemia should be avoided by close clinical
universal hypoglycemia screening is inappropriate, observation of vulnerable infants whilst avoiding
unnecessary, and potentially harmful. Nevertheless, excessively invasive management in populations of
many hospital nurseries continue the clinical neonates which may jeopardize the successful
practice of routine early glucose screening on establishment of breastfeeding.
241
Holtrop, P. C. 1993. “The frequency of symptomatic hypoglycemia should always be
hypoglycemia in full-term large and small for treated with a continuous infusion of parenteral
gestational age newborns,” Am. J. Perinatol., dextrose. Neonates needing dextrose infusion rates
vol. 10, no. 2, pp. 150–154. above 12mg/kg/m should be investigated for
refractory causes of hypoglycemia. Hypoglycemia
Abstract: Although various authors recommend
has been linked to poor neuro-developmental
screening for hypoglycemia in large for gestational
outcome and hence aggressive screening and
age (LGA) and small for gestational age (SGA)
treatment is recommended.
newborns, the frequency of hypoglycemia in these
infants, using a recent definition of hypoglycemia,
and the proper duration of screening are not Pal, D. K., D. S. Manandhar, S. Rajbhandari, J. M.
documented. We determined chromogen test strip Land, N. Patel, and L. C. A. de. 2000.
blood glucose values at ages 1, 2, 3, 6, 12, 24, 36, “Neonatal hypoglycaemia in Nepal 1.
and 48 hours in full-term LGA and SGA infants Prevalence and risk factors,” Arch. Dis. Child
whose mothers were not diabetic. Serum glucose Fetal Neonatal Ed, vol. 82, no. 1, pp. F46–F51.
determination was immediately done if a test strip
reading was less than 40mg/dl. Hypoglycemia was Abstract: OBJECTIVES: To measure the prevalence
defined as a serum glucose less than 35mg/dl at less of hypoglycemia among newborn infants in Nepal,
than 3 hours of age, less than 40mg/dl at 3 to 24 where classic risk factors prevail, and to evaluate
hours of age, and less than 45mg/dl at more than their importance. METHODS: A cross sectional
24 hours of age. The frequency of hypoglycemia in study was done of 578 term newborn infants aged
LGA infants was 8.1% (95% confidence interval 0 to 48 hours on the postnatal wards of a
[CI]: 5.0% to 11.2%), and in SGA infants, government maternity hospital in Kathmandu, with
14.7% (95% CI: 9.8% to 19.6%). The mean age unmatched case-control analysis of risk factors for
at which hypoglycemia occurred was 2.9 hours moderate hypoglycemia (less than 2.0mmol/l).
(range, 0.8 to 8.5) in LGA infants, and 6.1 hours RESULTS: Two hundred and thirty-eight
(range, 0.8 to 34.2) in SGA infants. There were no (41%) newborn infants had mild (less than
differences in other possible risk factors between 2.6mmol/l) and 66 (11%) moderate hypoglycemia.
the hypoglycemic and euglycemic infants except Significant independent risk factors for moderate
that in SGA infants meconium-stained amniotic hypoglycemia included postmaturity (OR=2.62),
fluid (40% vs. 20%, p=.001), maternal birthweight under 2.5kg (OR=2.11), small head
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
preeclampsia (27% vs. 8%, p=0.0056), and male size (OR=0.59), infant hemoglobin >210g/l
sex (29% vs. 9%, p=0.029) were more common in (OR=2.77), and raised maternal thyroid
hypoglycemic than in euglycemic infants. These stimulating hormone (TSH) (OR=3.08). Feeding
data suggest that screening for hypoglycemia in delay increased the risk of hypoglycemia at age
LGA infants whose mothers are not diabetic may 12–24 hours (OR=4.09). Disproportionality
be stopped after 12 hours, but should continue for affected the risk of moderate hypoglycemia: lower
48 hours in SGA infants. with increasing ponderal index (OR=0.29), higher
as the head circumference to birthweight ratio
increased (OR=1.41). Regression expressing blood
Narayan, S., R. Aggarwal, A. K. Deorari, and V. K. glucose concentration as a continuous variable
Paul. 2001. “Hypoglycemia in the newborn,” revealed associations with infant hemoglobin
Indian J. Pediatr., vol. 68, no. 10, pp. 963–965. (negative) and maternal hemoglobin (positive), but
no other textbook risk factors. CONCLUSIONS:
Abstract: Since a universal definition for
Neonatal hypoglycemia is more common in a
hypoglycemia is lacking, an operational threshold
developing country, but may not be a clinical
for initiating therapy has been defined.
problem unless all fuel availability is reduced. Some
Hypoglycemia is encountered in a variety of
textbook risk factors, such as hypothermia,
neonatal conditions including prematurity, growth
disappear after controlling for confounding
retardation and maternal diabetes. Since
variables. Early feeding could reduce moderate
hypoglycemia may be asymptomatic, routine
hypoglycemia in the second 12 hours of life. The
screening for this condition in certain high risk
clinical significance of raised maternal TSH and
situations is recommended. Supervised
maternal anemia as prenatal risk factors requires
breastfeeding may be a treatment option in
further research.
asymptomatic hypoglycemia. However,
242
Schaefer-Graf, U. M., R. Rossi, C. Buhrer, G. 163.0mg/dL, P<.006). There was an incremental
Siebert, S. L. Kjos, J. W. Dudenhausen, and K. risk of hypoglycemia with increasing one-hour oral
Vetter. 2002. “Rate and risk factors of glucose tolerance test values, with hypoglycemia
hypoglycemia in large-for-gestational-age rates of 2.5%, 9.3%, 22.0%, and 50.0% that were
newborn infants of nondiabetic mothers,” Am. associated with maternal one-hour glucose values
J. Obstet. Gynecol., vol. 187, no. 4, of <120, 120–179, 180–239, and > or = 240mg/dL,
pp. 913–917. respectively (P<.05, for all comparisons).
CONCLUSION: Routine glucose testing is
Abstract: OBJECTIVE: The purpose of this study
indicated in large-for-gestational-age newborn
was to investigate the rate of hypoglycemia in
infants of nondiabetic mothers. The one-hour
large-for-gestational-age infants of nondiabetic
glucose value of the maternal oral glucose tolerance
mothers in relation to maternal or neonatal risk
test is a fairly good predictor of subsequent
factors. STUDY DESIGN: Hospital charts of all
neonatal hypoglycemia. A single elevated one-hour
term large-for-gestational-age infants born between
value of > or = 180mg/dL markedly increases the
1994 and 1998 (n=1,136) were analyzed for the
risk of neonatal hypoglycemia.
rate of neonatal hypoglycemia (capillary glucose
level, < or =30mg/dL) during the first 24 hours of
life. Infants of women with preexisting or Williams, A. F. 1997. “Hypoglycaemia of the
gestational diabetes mellitus were excluded newborn: a review,” Bull. World Health
(n=180). Neonatal glucose testing was performed Organ., vol. 75, no. 3, pp. 261–290.
at 1 or 2 hours of life, with subsequent
measurements every 4 to 6 hours. Maternal and Abstract: It is almost a century since hypoglycemia
neonatal parameters were compared between (a reduction in the glucose concentration of
neonates with and without hypoglycemia, including circulating blood) was first described in children,
recent oral glucose tolerance test values in those and over 50 years since the condition was first
women who were tested (n=358). RESULTS: Of recognized in infants. Nevertheless, controversy
956 infants, 69 infants (7.2%) were not tested for still surrounds the definition, significance, and
hypoglycemia. In the remaining 887 infants, management of neonatal hypoglycemia.
hypoglycemia occurred in 142 infants (16%) Technological developments such as bedside
within the first 24 hours of life. The incidence of glucose monitoring have, paradoxically,
hypoglycemia decreased sharply during the first exacerbated rather than eased the situation. This
few hours of life, from 9.2% within the first hour article reviews the literature on hypoglycemia of
of life, to 3.5% between 2 to 5 hours (cumulative) the newborn, and covers the following: historical
of life, and 2.4% between 6 and 24 hours of life. aspects; glucose homeostasis and metabolic
Gestational age at delivery was the only neonatal adaptation at birth; the effect of low blood glucose
parameter that differed significantly between levels on the central nervous system; the definition
infants with and without hypoglycemia (39.5 of hypoglycemia; screening; prevention; treatment;
weeks vs. 39.3 weeks, P=.01). The antenatal one- research needs; and concludes with
hour oral glucose tolerance test value was the only recommendations for prevention and management.
predictive maternal parameter (141.5 vs.
NEONATAL HYPOGLYCEMIA
243
Neonatal Infections/Sepsis
Aggarwal, R., N. Sarkar, A. K. Deorari, and V. K. Abstract: OBJECTIVE: To achieve rapid
Paul. 2001. “Sepsis in the newborn,” Indian J. identification of neonatal sepsis. SETTING:
Pediatr., vol. 68, no. 12, pp. 1143–1147. Neonatal intensive care unit (NICU) of a teaching
hospital. METHOD: We evaluated 50 neonates
Abstract: Systemic infection in the newborn is the
who were admitted with clinical features suggesting
commonest cause of neonatal mortality. Data from
sepsis or who had principal risk factors, e.g.,
National Neonatal Perinatal Database 2000
prematurity (<36 weeks), low birthweight (<2.5kg),
suggest that Klebsiella pneumoniae and
H/o maternal pyrexia or prolonged rupture of
Staphylococcus aureus are the commonest causes
membranes, birth asphyxia, unbooked cases or
of neonatal sepsis in India. Two forms of clinical
instrumentation. Five tests, i.e., Total Leukocyte
presentations have been identified. Early onset
Count (T.L.C.), Absolute Neutrophil Count,
sepsis, probably related to perinatal risk factors,
Immature/Total Neutrophil ratio (I.T. ratio),
usually presents with respiratory distress and
Platelet count and C-Reactive protein were used for
pneumonia within 72 hours of age. Late onset
rapid diagnosis of neonatal sepsis. RESULTS: C-
sepsis, related to hospital acquired infections,
reactive protein (C.R.P.) and absolute Neutrophil
usually presents with septicemia and pneumonia
count had a sensitivity of over 60% with a
after 72 hours of age. Clinical features of sepsis are
specificity of 50%. White blood cell count had a
non-specific in neonates and a high index of
specificity of 93% but a sensitivity of 14%.
suspicion is required for the timely diagnosis of
CONCLUSION: None of the tests used alone were
sepsis. Although blood culture is the gold standard
reliable, but when in combination these five tests
for the diagnosis of sepsis, reports are available
may help to diagnose sepsis within a few hours.
after 48–72 hours. A practical septic screen for the
Also, if the tests show a high negative predictive
diagnosis of sepsis has been described and some
value, the neonate can be discharged early from the
suggestions for antibiotic use have been included in
hospital, stopping the antibiotics, thereby reducing
the protocols.
the cost of treatment and anxiety of the family.
245
epidermidis were most common. The organisms equal to 2.3°C (100% sensitivity) or greater than or
were least sensitive to Ampicillin (<20%) and equal to 3.2°C (100% specificity) is a useful marker
highly sensitive to Amikacin (90% to 100%), to differentiate normothermic preterms with or
Cefotaxime was also seen as a good choice of without sepsis. Using the axillary-sole temperature
antibiotic with sensitivity of (84%–89%). difference, the respective values were greater than
CONCLUSION: Gram-positive organisms were the or equal to 2.2°C and greater than or equal to
main cause of neonatal sepsis. Klebsiella sp. is still 3.0°C.
the most common organism causing early onset
sepsis. The data must be periodically reviewed and
antibiotic policy revised accordingly. Burman, L. G., P. Christensen, K. Christensen, B.
Fryklund, A. M. Helgesson, N. W. Svenningsen,
and K. Tullus. 1992. “Prevention of excess
Ayengar, V., Madhulika, and S. N. Vani. 1991. neonatal morbidity associated with group B
“Neonatal sepsis due to vertical transmission streptococci by vaginal chlorhexidine
from maternal genital tract,” Indian J. Pediatr., disinfection during labour. The Swedish
vol. 58, no. 5, pp. 661–664. Chlorhexidine Study Group,” Lancet, vol. 340,
no. 8811, pp. 65–69.
Abstract: High vaginal swabs (HVS) of
1,792 expectant mothers were sent for culture at Abstract: Streptococcus agalactiae transmitted to
the time of delivery, prior to first vaginal infants from the vagina during birth is an
examination. The newborns were followed-up for important cause of invasive neonatal infection. We
development of superficial or deep infections. have done a prospective, randomized, double-blind,
Appropriate cultures of the babies who developed placebo-controlled, multi-center study of
infections were sent. Bacterial growth of chlorhexidine prophylaxis to prevent neonatal
predominantly Gram-negative organisms was disease due to vaginal transmission of S. agalactiae.
obtained in 1,026 (57%) HVS. Infection developed On arrival in the delivery room, swabs were taken
in 48 (27%) babies in first 72 hours of life, of for culture from the vaginas of 4,483 women who
which 28 had deep infection while the rest had were expecting a full-term single birth. Vaginal
superficial infection. Vertical transmission of flushing was then done with either 60ml
organisms was documented in 24 (1.3%) mother- chlorhexidine diacetate (2g/l) (2,238 women) or
baby dyads and the same was 72% in newborns saline placebo (2,245) and this procedure was
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
who were at risk of developing sepsis by repeated every six hours until delivery. The rate of
septicemia scoring, showing a significantly higher admission of babies to special-care neonatal units
incidence of vertical transmission and subsequent within 48 hours of delivery was the primary end
sepsis in high risk newborns. point. For babies born to placebo-treated women,
maternal carriage of S. agalactiae was associated
with a significant increase in the rate of admission
Bhandari, V. and A. Narang. 1992. compared with non-colonised mothers (5.4% vs.
“Thermoregulatory alterations as a marker for 2.4%; RR=2.31, 95% CI: 1.39–3.86; p=0.002).
sepsis in normothermic premature neonates,” Chlorhexidine reduced the admission rate for
Indian Pediatr., vol. 29, no. 5, pp. 571–575. infants born of carrier mothers to 2.8% (RR=1.95,
Abstract: To evaluate the core-peripheral 95% CI: 0.94–4.03), and for infants born to all
temperature alterations as a marker for sepsis in mothers to 2.0% (RR=1.48, 95% CI: 1.01–2.16;
normothermic premature newborns, 50 normal p=0.04). Maternal S. agalactiae colonisation is
term neonates and 11 preterms with sepsis and associated with excess early neonatal morbidity,
11 normal preterms (controls) were studied. apparently related to aspiration of the organism,
Axillary, rectal and sole temperatures were recorded that can be reduced with chlorhexidine disinfection
in all babies using a single mercury-in-glass of the vagina during labor.
thermometer by a single observer. There was
significant widening of the rectal-sole and axillary-
Darmstadt, G. L., R. E. Black, and M. Santosham.
sole temperatures in the preterms with sepsis
2000. “Research priorities and postpartum care
(p<0.001). There was no significant difference
strategies for the prevention and optimal
(p>0.05) between the axillary and rectal
management of neonatal infections in less
temperatures in the term, normal preterms or those
developed countries,” Pediatr. Infect. Dis. J.,
with sepsis. With an overall accuracy of 90.9%, a
vol. 19, no. 8, pp. 739–750.
rectal-sole temperature difference of greater than or
246
Donkers, L. E., A. M. van Furth, W. C. van der a contaminated intrauterine environment,
Zwet, W. P. Fetter, J. J. Roord, and C. M. regardless of gestation age and the baby’s culture
Vandenbroucke-Grauls. 2001. “Enterobacter results. Successes with intrapartum antibiotic
cloacae epidemic on a neonatal intensive care prophylaxis decreasing rates of GBS sepsis and
unit due to the use of contaminated maternal chorioamnionitis, have heartened care
thermometers,” Ned. Tijdschr. Geneeskd., providers and parents. These results demonstrate
vol. 145, no. 13, pp. 643–647. the advances possible when specific diseases are
made a national health priority, and good clinical
Abstract: From December 1999 to March 2000 a
trial work is applied to clinical practice.
nosocomial outbreak of multiresistant Enterobacter
cloacae occurred in the neonatal intensive care unit
(NICU) at the VU Medical Center, Amsterdam, the Fransen, L., B. P. Van den, A. Mertens, K. Van
Netherlands. Twenty-six patients were infected or Brussel, R. Clara, and P. Piot. 1987. “Incidence
colonized with this strain resistant to third and bacterial aetiology of neonatal
generation cephalosporins and with decreased conjunctivitis,” Eur. J. Pediatr., vol. 146, no. 2,
sensitivity for aminoglycosides. Three neonates pp. 152–155.
experienced sepsis with E. cloacae with serious
clinical symptoms and two of them died. Abstract: Two hundred and twenty-nine infants
Comparison of the Enterobacter isolates by born consecutively at the maternity ward of the
amplified-fragment length polymorphism indicated Middelheim Hospital in Antwerp, over a period of
that this outbreak was caused by the spread of a five months, and an additional 55 randomly
single strain. Infection control precautions were selected infants born at the same hospital were
initiated in order to stop further spread; barrier clinically and microbiologically investigated before
precautions, enforcement of hand disinfection and leaving the maternity ward. All infants born at this
cohorting of colonized patients. A multidisciplinary maternity ward received argyrol eye drops
crisis team coordinated these infection control immediately after birth. Twenty-six (11%) of the
precautions and informed all persons involved. infants consecutively investigated had neonatal
Analysis of antibiotic usage in 1999 showed an conjunctivitis diagnosed before leaving the
increase in the use of third generation maternity ward, where they stayed from seven to
cephalosporins from November onwards. Due to ten days. Another 29 infants were reported to have
the resistance pattern of the epidemic strain the use developed sticky eyes and/or red eyes after leaving
of third generation cephalosporins was the maternity hospital and before one month of
discontinued in February 2000. At the end of age. The instantaneous risk of developing, a
February the NICU was temporarily closed. The conjunctivitis was equal for each day of the first
epidemic strain of E. cloacae was isolated from one month of life. Chlamydia trachomatis was isolated
digital rectal thermometer. Patient use of from the eyes of 11 of the 229 (4.8%)
thermometers and disposable coverings for rectal consecutively born infants but only one had
thermometers were introduced to eliminate this conjunctivitis symptoms before leaving the
possible means of spread. No spread of maternity ward. Overall one or more bacterial
multiresistant E. cloacae was found following the species could be isolated from the eyes of 143
introduction of these interventions. Once all the (48%) of the infants, but only Viridans streptococci
neonates had been transferred, the NICU was and Staphylococcus aureus were cultured
disinfected and reopened in March. significantly more often from the eyes of cases with
conjunctivitis than from the eyes of the infants
without conjunctivitis (P<0.001).
NEONATAL INFECTIONS/SEPSIS
247
based strategy to a risk-based strategy as regards Henrichsen, T., R. Lindemann, L. Svenningsen, and
the incidence of early-onset group B streptococcus K. Hjelle. 1994. “Prevention of neonatal
(GBS) infection among term infants. STUDY infections by vaginal chlorhexidine disinfection
DESIGN: A cohort of university hospital prenatal during labour,” Acta Paediatr., vol. 83, no. 9,
clinic mother-infant pairs who were screened for pp. 923–926.
GBS at 35 to 37 weeks’ gestation were compared
Abstract: Comparison of two different methods of
to a matched control group of unscreened mother-
vaginal disinfection was made with regard to
infant pairs from the outreach satellite prenatal
prevention of neonatal infections. In method I, an
clinics who delivered at the same institution during
antepartum vaginal douche with a chlorhexidine
the same time period. GBS screening was carried
solution was used; method II involved the use of
out with rectovaginal cultures plated on selective
chlorhexidine gluconate obstetrical gel during
media. GBS-positive women received antimicrobial
vaginal exploration. We studied 2,853 normal
prophylaxis in labor whereas women of unknown
deliveries from a total number of 3,236 deliveries:
GBS status were only treated intrapartum if they
1,467 deliveries were allocated randomly to receive
had a risk factor for GBS infection. Principal
a vaginal douche whereas 1,386 underwent vaginal
outcome variables included incidence of cases of
exploration using chlorhexidine gel. A total of
neonatal early-onset GBS sepsis (blood, urine, or
203 neonates were transferred to the neonatal unit
cerebrospinal fluid positive for GBS), incidence of
(120 males and 83 females): 101 belonged to the
cases of strongly suspected GBS sepsis (culture
group where the mothers were subjected to method
negative), and incidence of neonatal sepsis with
I, whereas in 102 method II had been used. Within
non-GBS organisms. RESULTS: There were 3,164
48 hours postpartum 30 neonates from the method
screened mother-infant pairs who were compared
I group and 34 neonates from the method II group
to 2,684 unscreened pairs. The incidence of GBS
received systemic antibiotics. There was a tendency
carriage was 13.3%. A random sample of
towards a higher proportion of full-term neonates
420 screened women were compared to a matched
with verified septicemia in the method II group (6
sample of 407 women of unknown GBS carrier
versus 2), whereas the numbers of probable
status for characterization of demographics and
infections were 8 versus 12. The corresponding
risk factors. No cases of documented GBS sepsis
total numbers in preterm infants were three and
occurred in the infants of the screened women, but
two, respectively. These differences were not
four cases occurred among the infants of the
statistically significant. We conclude that the use of
women who did not undergo screening (incidence
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
248
cheap diagnostic tools urgently. Access to health Isenberg, S. J., L. Apt, and M. Wood. 1996, “The
care in the remote city is limited. Newer drugs are influence of perinatal infective factors on
too expensive and very few patients can benefit ophthalmia neonatorum,” J. Pediatr.
from these. Each developing country should Ophthalmol. Strabismus, vol. 33, no. 3,
prioritize its PI problems and tackle those that have pp. 185–188.
serious public health problems and socio-economic
Abstract: BACKGROUND: Ophthalmia
impact. Most developing countries should focus on
neonatorum still blinds approximately
HIV (human immunodeficiency virus) and HBV
10,000 babies annually worldwide. Identification of
(hepatitis B virus) infections. Other countries where
contributory maternal perinatal factors could
ophthalmia, malaria or tuberculosis are prevalent
possibly predict which babies are at greater risk for
or endemic, should focus on these. Developing
this disease. METHODS: In a randomized
countries are more willing to allocate the budget
prospective study of ophthalmia neonatorum in
for prevention of diseases than for treatment. There
Kenya, we studied the effect of prophylaxis with
may be problem of promulgating the information
povidone-iodine, silver nitrate, and erythromycin in
on prevention of diseases because of illiteracy,
3,117 neonates. Four perinatal factors that may
multi-lingual community. Vaccines where available,
promote ophthalmia neonatorum were investigated:
should be affordable. Other effective prevention
maternal vaginitis, birth in a nonsterile
guidelines should be workable in poorer nations.
environment, presence of meconium at birth, and
The government should play an important role in
postnatal development of endometritis. RESULTS:
enforcing immunization program by intensive
No significant difference in the general ophthalmia
promotion program or by legislation.
neonatorum rate was found for any of the four
factors (P>.14 by Fisher exact test). However, with
Iroha, E. O., C. N. Kesah, M. T. Egri-Okwaji, and regard to venereal ophthalmia neonatorum, the 26
T. O. Odugbemi. 1998. “Bacterial eye infection infants born to mothers with vaginitis had a relative
in neonates, a prospective study in a neonatal risk 5.1 times that of the rest of the infants
unit,” West Afr. J. Med., vol. 17, no. 3, (P=0.0013). Their relative risk to develop
pp. 168–172. gonococcal ophthalmia neonatorum in particular
was 24.9 times the rest of the neonates
Abstract: One hundred and fifty-five neonates with (P=0.0000031). Prophylaxis was with povidone-
conjunctivitis admitted into the neonatal unit at the iodine in 12 infants, silver nitrate in two, and
Lagos University Teaching Hospital were erythromycin in 12. The frequency of ophthalmia
microbiologically investigated. This was to neonatorum was 25%, 100%, and 33%,
determine the bacterial etiologic agent(s) in respectively (differences not significant).
neonatal eye infection and highlight some risk CONCLUSION: Neonates born to mothers with
factors. Antimicrobial susceptibility testing was vaginitis should be carefully observed for the first
done on the pathogens isolated using the diskagar postnatal month for the development of ophthalmia
diffusion method. The incidence of conjunctivitis in neonatorum, even though a prophylactic agent has
the newborn was 18 per 1,000 live births. been used.
Predisposing factor noted were vaginal delivery,
asphyxia neonatorum and prolonged rupture of
membrane. Pathogens predominantly isolated were Johnson, D. and H. McKenna. 1975. “Bacteria in
Staphylococcus aureus (37.4%), Coagilase-negative ophthalmia neonatorum,” Pathology, vol. 7,
Staphylococci (12.3%), Klebsiella pneumoniae no. 3, pp. 199–201.
(12.9%) and Pseudomonas aeruginosa (8.2%).
NEONATAL INFECTIONS/SEPSIS
Abstract: A four-year study of the bacteria isolated
Antimicrobial suscepibility results revealed varied
from neonatal eye swabs at Royal Women’s
degrees of susceptibility to ofloxacin (75%),
Hospital, Brisbane has been carried out. Of infants
Cloxacillin, erythromycin, Gentamicin and
admitted to nurseries 2.7% (571/21,217) had
augumentin (30%) by the Gram-positive bacteria
positive cultures. The incidence of infection in
while most of the Gram-negative were susceptible
premature non-premature nurseries was
to colistin and ofloxacin (above 90%). The high
9.7% (221/2,273) and 1.8% (350/18,944)
incidence of bacterial eye infection should be
respectively, a highly significant difference. There
minimized by the elimination of the risk factors
was a preponderance of Gram-negative organisms
and adoption of stringent aseptic measures in the
in the former (67%) and of Gram-positive
care of the neonate.
organisms in the latter (69%), each a statistically
significant difference. Neisseria gonorrheae was
isolated eight times (1.4%) during this period.
249
Kaihura, C. T., L.Ricci, L. Bedocchi, G. Barbara, this issue. METHODS: 6,295 women in
T. Rossi, G. Benassi, and L. Benassi. 2000. spontaneous preterm labor with intact membranes
“Lavage of the birth canal with chlorhexidine: a and without evidence of clinical infection were
new valid method for the prevention of randomly assigned 250mg erythromycin
perinatal infections,” Acta. Biomed. Ateneo. (n=1,611), 325mg co-amoxiclav (250mg
Parmense., vol. 71 Suppl 1, pp. 567–571. amoxicillin and 125mg clavulanic acid; n=1,550),
both (n=1,565), or placebo (n=1,569) four times
Abstract: Perinatal morbidity and mortality are
daily for 10 days or until delivery, whichever
due to various infective agents, mainly represented
occurred earlier. The primary outcome measure
by beta-hemolytic group B Streptococcus. The
was a composite of neonatal death, chronic lung
perinatal disease related to this infection is
disease, or major cerebral abnormality on
distinguished in Early-onset, characterized by
ultrasonography before discharge from hospital.
pneumonia and sepsis, and Late-onset which leads
Analysis was by intention to treat. FINDINGS:
to sepsis, meningitis and pneumonia. Various
None of the trial antibiotics was associated with a
strategies were therefore proposed to prevent
lower rate of the composite primary outcome than
transmission including immunization and
placebo (erythromycin 90 [5.6%], co-amoxiclav
chemoprophylaxis. All these methods however
76 [5.0%], both antibiotics 91 [5.9%], vs. placebo
present adverse effects and are most of all
78 [5.0%]). However, antibiotic prescription was
expensive to carry out. Taha et al. reported an
associated with a lower occurrence of maternal
interesting experience regarding the reduction of
infection. INTERPRETATION: This trial provides
perinatal infections following the cleansing of the
evidence that antibiotics should not be routinely
birth canal with a solution of Chlorhexidine
prescribed for women in spontaneous preterm
0.25% during labor (1996–1997). It seemed
labor without evidence of clinical infection.
interesting for us to assess the applicability and
efficacy of a new strategy of prophylaxis of
perinatal infections in a Developing Country based Kenyon, S., M. Boulvain, and J. Neilson. 2001.
on the association of two of the simple strategies “Antibiotics for preterm premature rupture of
proposed i.e.: cleansing the birth canal with membranes,” Cochrane. Database Syst. Rev.,
chlorhexidine and chemoprophylaxis in cases with no. 4, p. CD001058.
risk factors without culture screening. We studied
two groups of patients: one in which cleansing of Abstract: BACKGROUND: The consequences of
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
the birth canal was used and the second (control prematurity continue to result in neonatal
group) in which the old method already applied in morbidity and mortality. One of the causes of
the hospital (i.e. cleansing of the external genitals prematurity is preterm prelabor rupture of
with Cetrimide 1%+ Chlorhexidine 0.1%) was membranes in which there is evidence that
carried out associated with antibiotic therapy subclinical infection plays a role. OBJECTIVES:
when risk factors arose. We observed a total The aim of the review was to evaluate the
absence of neonatal mortality due to sepsis effectiveness and the immediate and long-term
resulting from the association of the methods safety of the effects of administering antibiotics to
suggested even though the presence of sepsis women with preterm prelabor rupture of
evaluated through signs and symptoms like fever, membranes on maternal infectious morbidity, fetal
poor feeding, apnea or dyspnoea in newborns was and neonatal morbidity and mortality, and longer
similar in both groups. term childhood development. SEARCH
STRATEGY: All randomized trials identified using
the search strategy described by the Cochrane
Kenyon, S. L., D. J. Taylor, and W. Tarnow-Mordi. Pregnancy and Childbirth Group. Date of last
2001. “Broad-spectrum antibiotics for search: 31 May 2001. SELECTION CRITERIA:
spontaneous preterm labour: the ORACLE II All trials which reported clinically relevant
randomized trial. ORACLE Collaborative outcomes (as opposed to laboratory data) were
Group,” Lancet, vol. 357, no. 9261, included. DATA COLLECTION AND ANALYSIS:
pp. 989–994. Data were extracted from each report without any
blinding of either the results or the treatments
Abstract: BACKGROUND: Preterm birth after
which women received. Unpublished data were
spontaneous preterm labor is associated with
sought from a number of authors. MAIN
death, neonatal disease, and long-term disability.
RESULTS: There were 13 trials included in the
Previous small trials of antibiotics for spontaneous
review which randomized over 6,000 women and
preterm labor have reported inconclusive results.
their babies. The use of antibiotics following
We did a randomized multicenter trial to resolve
250
preterm prelabor rupture of membranes (pPROM) Khan, M. A., M. Abdur-Rab, N. Israr, M. Ilyas, F.
is associated with a statistically significant Ahmad, Z. Kundi, and A. Ghafoor. 1991.
reduction in maternal infection after delivery prior “Transmission of Salmonella worthington by
to discharge (relative risk (RR)=0.85, 95% oropharyngeal suction in hospital neonatal
confidence interval (CI): 0.76, 0.96) and morbidity unit,” Pediatr. Infect. Dis. J., vol. 10, no. 9,
(including chlorination) (RR=0.62, 95% CI: 0.51, pp. 668–672.
0.75) There was a statistically significant reduction
Abstract: An outbreak of Salmonella worthington
in the numbers of babies born within 48 hours
infection in a neonatal unit occurred in a pediatric
(RR=0.77, 95% CI: 0.72, 0.83) and seven days
ward of Holy Family Hospital, Rawalpindi,
RR=0.88, 95% CI: 0.84, 0.92) of randomization.
Pakistan. The index case was a prematurely born
Neonatal infection (including pneumonia)
male child from whose clinical specimens
(RR=0.67, 95% CI: 0.52, 0.85) and positive blood
S. worthington was recovered. After this finding
culture (RR=0.75, 95% CI: 0.60, 0.93) were
40 infants kept in that nursery were included in an
statistically significantly reduced in the babies
investigation. Major symptoms were diarrhea,
whose mothers received antibiotics as was the
septicemia and jaundice. Three developed
numbers of babies requiring oxygen therapy
meningitis. Disease morbidity rate was 45% and
overall (RR=0.88, 95% CI: 0.81, 0.96) and at
mortality occurred in 16.6% of the total positive
28 days of age or older (RR=0.81, 95% CI:
cases. The source of infection was traced to a
0.68, 0.97). One trial (ORACLE) found a
contaminated rubber tubing of a suction apparatus
statistically significant reduction in the use of
which was used for oropharyngeal suction of the
surfactant (RR=0.83, 95% CI: 0.72, 0.96). There
babies. S. worthington was recovered from the
was also a statistically significant reduction in the
clinical specimens of all 18 babies who received
number of babies diagnosed with abnormal
suction. Multiple drug resistance of these S.
cerebral ultrasound (RR=0.82, 95% CI: 0.68,
worthington strains was found.
0.99) scans prior to discharge from hospital.
Overall, there was no evidence of adverse effect.
Intrinsically there are fewer data relating to King, J. and V. Flenady. 2000. “Antibiotics for
specific antibiotics. When looking at the effect of preterm labour with intact membranes,”
beta lactum antibiotics (augmentin) where two Cochrane. Database Syst. Rev., no. 2,
trials were included, there was a statistically p. CD000246.
significant reduction in the number of babies born
within 48 hours (RR=0.75, 95% CI: 0.67, 0.84) Abstract: BACKGROUND: There may be a link
and seven days (RR=0.91, 95% CI: 0.85, 0.97) of between infection and preterm birth.
randomization. However, there was a highly OBJECTIVES: Since rupture of the membranes is
significant increase in the numbers of babies with an important factor in the progression of preterm
necrotising enterocolitis (RR=4.60, 95% CI: labor, it is important to see if antibiotics are of any
1.98, 10.72) in the augmentin treatment group. benefit prior to membrane rupture. The objective
The effect of macrolide antibiotics (erythromycin), of this review was to assess the effects of
included four trials and found statistically antibiotics administered to women in preterm labor
significant reductions in the number of babes born with intact membranes, on maternal and neonatal
within 48 hours (RR=0.84, 95% CI: 0.76, 0.93) of outcomes. SEARCH STRATEGY: We searched the
randomization but delivery <7 days did not Cochrane Pregnancy and Childbirth Group trials
exclude unity. There was statistically significant register and reference lists of articles. We contacted
reductions in those requiring oxygen therapy experts in the field. SELECTION CRITERIA: NEONATAL INFECTIONS/SEPSIS
(RR=0.87, 95% CI: 0.78, 0.98) and those with a randomized trials which compared antibiotic
positive blood culture (RR=0.70, 95% CI: treatment with placebo or no treatment for women
0.52, 0.94). REVIEWER’S CONCLUSIONS: in preterm labor (between 20 and 36 weeks’
There are sufficient data to recommend routine gestation) with intact membranes. DATA
prescription of macrolide antibiotics in this clinical COLLECTION AND ANALYSIS: Trial quality was
situation. The routine prescription of macrolide assessed and data were extracted independently by
antibiotic (erythromycin) is recommended as beta two reviewers. Study authors were contacted for
lactum antibiotics (augmentin) is associated with a missing data. MAIN RESULTS: Meta-analysis of
statistically significant increase in neonatal the ten included trials demonstrated a statistically
necrotising enterocolitis. significant prolongation of pregnancy associated
with the use of antibiotics (5. 4 days, 95%
confidence interval (CI): 0.9–9.8 days). Antibiotic
251
treatment was also associated with a statistically 68%; specificity: 100%). At 96 hours the
significant reduction in maternal infection (odds predictors were seizure duration of >72 hours,
ratio (OR)=0.59, 95% CI: 0.36, 0.97) and neonatal presence of coma, use of inotropes, and leukopenia
necrotising enterocolitis (OR=0.33, 95% CI: (sensitivity: 88%; specificity: 99%).
0.13, 0.88). No statistically significant effect was CONCLUSIONS: Most infants at risk for adverse
detected on the neonatal outcomes of respiratory outcome can be identified within 12 hours of
distress syndrome and neonatal sepsis, although admission. Duration of seizures for >72 hours,
there was a trend towards the latter (OR=0.67, presence of coma, use of inotropes, and leukopenia
95% CI: 0.42, 1.07). An increase in perinatal were the most important predictors of adverse
mortality was observed in the group receiving outcome. Although these models have good
antibiotics (OR=3.36, 95% CI: 1.21, 9.32). predictive accuracy, they need to be validated in a
REVIEWER’S CONCLUSIONS: Although a contemporary cohort in large multicenter studies.
prolongation in time to delivery and a trend
towards a reduction in neonatal sepsis was
detected, this review fails to demonstrate a clear Larson, E. L., K. J. McGinley, A. Foglia, J. J.
overall benefit from antibiotic treatment for Leyden, N. Boland, J. Larson, L. C. Altobelli,
preterm labor with intact membranes on neonatal and E. Salazar-Lindo. 1992. “Handwashing
outcomes and raises concerns about increased practices and resistance and density of bacterial
perinatal mortality for those who received hand flora on two pediatric units in Lima,
antibiotics. This treatment cannot therefore be Peru,” Am. J. Infect. Control, vol. 20, no. 2,
currently recommended for routine practice. pp. 65–72.
Further research is required to identify a subgroup Abstract: The handwashing practices and bacterial
of women (and their babies) who are more likely to hand flora of 62 pediatric staff members of a
experience benefit from antibiotic treatment for teaching hospital in Lima, Peru, were studied.
preterm labor prior to membrane rupture, and to Handwashing followed patient contact 29.3% of
identify which antibiotic or combination of the time (204/697 contacts). Mean duration was
antibiotics is most effective. The results of the 14.5 seconds, and significant differences in
ongoing ORACLE trial should help resolve some of practices were found by unit (rehydration or
the uncertainties revealed by this review. neonatal intensive care), type of staff member
(nurses or physicians), and type and duration of
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
252
onset of symptoms); accordingly, there is the lived in with their sick neonates and were
possibility of including late-onset maternally extremely useful in feeding, cleaning, and
acquired sepsis or of excluding early-onset monitoring for some important signs and
nosocomial sepsis (<3–7 days of life). For these symptoms. There were no epidemics of infection in
reasons, in this study, cases of nosocomial sepsis the nursery during this period. All the babies
that developed at < or = 3–7 days after birth (early discharged were receiving breastfeeds, and the
onset) were also recorded and maternally acquired mothers were confident in taking care of them
sepsis diagnosed beyond 3–7 days of life were before discharge. The mortality in this group was
excluded. Using these criteria in a total of 30,993 43%. The onset of septicemia was most often in
admissions to the neonatal units of the the first week (36%) being 25.9% in second week,
participating hospitals, the nosocomial sepsis rate 26.6% in the third, and 11.4% in the fourth.
was 2.1% with an incidence density of 0.89 per Mortality was maximum (64.5%) when the onset
1,000 patient days. Sepsis rate was significantly of illness was in the first three days. Klebsiella and
more frequent among very low birthweight S. aureus were commonly isolated organisms
(VLBW) infants (15.6%) than among those (38.6% and 21.5%, respectively). Gram-negative
weighing > or = 1,500g (1.16%) (P<0.001). Fifty- organisms were isolated in 66.5% cases with
eight percent of all isolates were Gram-positive higher mortality in this group. Nearly 46% of the
organisms, mainly Staphylococcus epidermidis babies weighed 2kg or less, with a mortality of
(42%). Gram-negative organisms were isolated in 60.2% compared to 28.2% in those more than
29.5% of cases (Escherichia coli and Klebsiella 2kg. Only 3% to 5% and 40% to 66.7% of Gram-
spp. were the most commonly isolated pathogens) negative and 23% and 70% of Gram-positive
and fungal infections in 12%, with absolute organisms were sensitive to ampicillin and
predominance of Candida spp. The overall gentamicin, respectively.
mortality rate was 11.8% and the following
subgroups had significantly higher (P<0.001)
mortality rates: sepsis caused by Gram-negative Mercer, B. M., M. Miodovnik, G. R. Thurnau, R.
organisms (19% vs. 5.1% in Gram-positive L. Goldenberg, A. F. Das, R. D. Ramsey, et al.
pathogens) and sepsis caused by Pseudomonas 1997. “Antibiotic therapy for reduction of
aeruginosa (33.3% vs. 9.4% for the total number infant morbidity after preterm premature
of sepsis caused by the remaining causative rupture of the membranes. A randomized
pathogens). Sepsis caused by S. epidermidis showed controlled trial. National Institute of Child
a significantly lower mortality rate (5.5%) Health and Human Development Maternal-
compared with overall sepsis for the remaining Fetal Medicine Units Network,” JAMA,
etiologies (14.2%) (P<0.001). In VLBW infants, the vol. 278, no. 12, pp. 989–995.
mortality rate was significantly higher than in Abstract: CONTEXT: Intrauterine infection is
infants weighing >1,500g (17.3% vs. 6.5%, thought to be one cause of preterm premature
P<0.001). rupture of the membranes (PPROM). Antibiotic
therapy has been shown to prolong pregnancy, but
the effect on infant morbidity has been
Mathur, N. B., A. Khalil, R. Sarkar, and R. K.
inconsistent. OBJECTIVE: To determine if
Puri. 1991. “Mortality in neonatal septicemia
antibiotic treatment during expectant management
with involvement of mother in management,”
of PPROM will reduce infant morbidity. DESIGN:
Indian Pediatr., vol. 28, no. 11,
Randomized, double-blind, placebo-controlled
pp. 1259–1263.
trial. SETTING: University hospitals of the
NEONATAL INFECTIONS/SEPSIS
Abstract: In most Special Care Neonatal Units National Institute of Child Health and Human
(SCNUs) in India, mothers are excluded from the Development Maternal-Fetal Medicine Units
care of their sick babies for fear of over-crowding Network. PATIENTS: A total of 614 of
and dislocation. We have attempted to study the 804 eligible gravidas with PPROM between
feasibility of involving mothers in the care of their 24 weeks’ and zero days’ and 32 weeks’ and zero
babies admitted for neonatal septicemia and to days’ gestation who were considered candidates for
analyze whether this changed the sepsis related case pregnancy prolongation and had not received
fatality rate. The study material consisted of corticosteroids for fetal maturation or antibiotic
158 neonates with blood culture positive neonatal treatment within one week of randomization.
septicemia whose mothers were actively involved in INTERVENTIONS: Intravenous ampicillin
their care during their stay in the SCNU of LNJPN (2g dose every 6 hours) and erythromycin
Hospital throughout 1987–1988. The mothers (250mg dose every 6 hours) for 48 hours followed
253
by oral amoxicillin (250mg dose every 8 hours) was due to other causes. This was mainly the result
and erythromycin base (333mg dose every 8 hours) of the high frequency of amniotic-fluid infections
for five days vs. a matching placebo regimen. associated with the premature membrane ruptures.
Group B streptococcus (GBS) carriers were
identified and treated. Tocolysis and corticosteroids
were prohibited after randomization. MAIN Nathoo, K. J., I. Pazvakavamba, O. S. Chidede,
OUTCOME MEASURES: The composite primary and C. Chirisa. 1991. “Neonatal meningitis in
outcome included pregnancies complicated by at Harare, Zimbabwe: a 2-year review,” Ann.
least one of the following: fetal or infant death, Trop. Paediatr., vol. 11, no. 1, pp. 11–15.
respiratory distress, severe intraventricular Abstract: A two-year review of neonatal
hemorrhage, stage 2 or 3 necrotizing enterocolitis, meningitis was undertaken at a referral hospital in
or sepsis within 72 hours of birth. These perinatal Zimbabwe to determine the pattern of bacterial
morbidities were also evaluated individually and isolates from the cerebrospinal fluid, the clinical
pregnancy prolongation was assessed. RESULTS: In presentation and the immediate outcome. During
the total study population, the primary outcome the study period, 94 cases were identified and the
(44.1% vs. 52.9%; P=.04), respiratory distress overall mortality was 41%. Group B
(40.5% vs. 48.7%; P=.04), and necrotizing Streptococcus was the predominant organism
enterocolitis (2.3% vs. 5.8%; P=.03) were less isolated (61%) and was associated with
frequent with antibiotics. In the GBS-negative 42% mortality. Low birthweight babies and
cohort, the antibiotic group had less frequent babies with Gram-negative meningitis had
primary outcome (44.5% vs. 54.5%; P=.03), mortality rates of 71% and 62%, respectively.
respiratory distress (40.8% vs. 50.6%; P=.03),
overall sepsis (8.4% vs. 15.6%; P=.01), pneumonia
(2.9% vs. 7.0%; P=.04), and other morbidities. Nel, E. 2000. “Neonatal meningitis: mortality,
Among GBS-negative women, significant cerebrospinal fluid, and microbiological
pregnancy prolongation was seen with antibiotics findings,” J. Trop. Pediatr., vol. 46, no. 4,
(P<.001). CONCLUSIONS: We recommend that pp. 237–239.
women with expectantly managed PPROM remote Abstract: This study describes the bacteriology,
from term receive antibiotics to reduce infant cerebrospinal fluid (CSF) findings, and mortality of
morbidity. neonatal meningitis over an 11-year period. The
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
254
Abstract: The importance of hands in the Chloramphenicol) applied six times per day. The
transmission of nosocomial infection has been subjects were followed up with two visits (on days
world wide admitted. However, it is difficult to 1 and 8) and by telephone two weeks after the end
induce this behavior in health-care workers. The of treatment. RESULTS: Eighty-nine percent of the
aim of the present work was to point out the neonates treated with Fucithalmic were cured,
importance of hand bacteria colonization, the compared to 87.9% of those treated with Minims
influence of hand washing and of patient physical Chloramphenicol (n.s). The drug was used as
examination. One hundred health-care workers instructed in 90.7% of patients treated with
were randomly divided in two groups: Group A Fucithalmic and in 78.0% of those treated with
without hand washing previous to patient physical Minims Chloramphenicol (P<0.001).
examination or handling (PPE); Group B with hand CONCLUSION: Treating neonatal conjunctivitis
washing previous to PPE. Direct fingerprint with fucidic acid is easier than with
samples in Columbia agar before and after PPE chloramphenicol and is equally effective.
were obtained. The colonies were counted and
identified by conventional techniques, and
antibiograms according to NCCLS were Ogawa, M., A. Kojima, H. Taniguchi, and T.
performed. Before PPE Group A participants Matsumoto. 2000. “A survey on contamination
showed a high number of bacteria regarding Group by microorganisms and the effect of
B participants (73.9 vs. 20.7; p<0.001); 44 out of handwashing by doctors and nurses at the
50 participants were carriers of potentially UOEH Hospital,” J. UOEH., vol. 22, no. 4,
pathogen bacteria. No Group B participants were pp. 339–349.
carriers of potential pathogen bacteria before PPE. Abstract: Handwashing is very basic and important
The latter group showed an increase in number of in controlling nosocomial infection. We researched
bacteria after PPE (20.7 CFU (before) vs. the effect of handwashing by doctors and nurses at
115.9 CFU (after); p<0.001). Sixteen Group B the UOEH Hospital. One hundred and eight
participants were contaminated after PPE with doctors and 114 nurses of 19 wards were
potential pathogens such as S. aureus (50% of examined. The number of bacteria was determined
them methicillin resistant); Escherichia coli, by a palm stamp check agar plate for general
Pseudomonas aeruginosa and Enterococcus bacteria before and after handwashing. The
faecalis, half of them multiresistant. We can difference in the condition of microorganism
conclude on the importance of these results to contamination among the wards was found by the
implement educational programs and to provide number of bacteria before handwashing, and by
the health-care workers with the proper comparing the number of bacteria before and after
commodities to fulfill this practice. handwashing, the effect of handwashing was
determined. Handwashing by water or soap is not
effective in killing bacteria. Therefore, we suggest
Normann, E. K., O. Bakken, J. Peltola, B.
that doctors and nurses use an effective disinfectant
Andreasson, S. Buhl, P. Sigg, and K. Nielsen.
when washing their hands before and after contact
2002. “Treatment of acute neonatal bacterial
with patients. We also think that the results noted
conjunctivitis: a comparison of fucidic acid to
in this paper will help doctors and nurses to have a
chloramphenicol eye drops,” Acta. Ophthalmol.
better understanding of the importance of infection
Scand., vol. 80, no. 2, pp. 183–187.
control.
Abstract: PURPOSE: To compare the clinical and
bacteriological effects of fucidic acid (Fucithalmic:
NEONATAL INFECTIONS/SEPSIS
255
Pierce, J. M., M. E. Ward, and D. V. Seal. 1982. clinical diagnosis of neonatal sepsis was cultured.
“Ophthalmia neonatorum in the 1980s: The data obtained from October 1997 to
incidence, aetiology and treatment,” Br. J. December 2000 were analyzed and the results
Ophthalmol., vol. 66, no. 11, pp. 728–731. tabulated. RESULTS: A total of 1,598 blood
cultures were taken; 1,003 were positive (positivity
Abstract: In a survey of 450 consecutive births in
rate 62.8%). Escherichia coli was the most
Southampton a 12% incidence has been found of
common organism found (36.6%), followed by
ophthalmia neonatorum. Bacterial pathogens were
Staphylococcus aureus (29.5%), Pseudomonas
isolated from only one-third of the cases, while
(22.4%), Klebsiella (7.6%), and Proteus (3.8%).
nonpathogens were isolated from as many cases as
No group B streptococcus was grown. Listeria
controls. There was an incidence of chlamydial
monocytogenes was found in one cerebrospinal
infection of 3.7 per 1,000 live births, while
fluid culture. E. coli and Pseudomonas showed a
Neisseria gonorrheae could not be found.
high degree of resistance to commonly used
Chloramphenicol is recommended for topical
antibiotics (ampicillin, augmentin, and gentamicin),
antibacterial treatment, but chlamydial infection
a moderate degree of resistance to cephalosporin
will not respond; it must be considered in
(cefotaxime, ceftzidime, and ceftrioxone), and low
“resistant” cases, when both the neonate and the
resistance to drugs not used for newborn babies
parents will need treatment with erythromycin or
(ofloxacin, ciprofloxacin, and enoxabid). S. aureus
tetracycline.
showed a low resistance to all three groups of
antibiotics. CONCLUSION: Neonatal sepsis
Polin, R. A. and M. C. Harris. 2001. “Neonatal remains one of the leading causes of neonatal
bacterial meningitis,” Semin. Neonatol., vol. 6, admission, morbidity, and mortality in developing
no. 2, pp. 157–172. countries. Gram-negative organisms are the major
cause of neonatal sepsis in Peshawar. Such
Abstract: Despite major improvements in infant organisms have developed multidrug resistance,
intensive care, neonatal meningitis remains a and management of patients infected with them is
devastating disease. Survivors of bacterial becoming a problem in developing countries.
meningitis are at high-risk for life-long neurological
handicaps, and despite a reduction in mortality, the
morbidity of neonatal meningitis has not changed Ramsey, K. H., C. E. Poulsen, and P. P. Motiu.
substantially over the last thirty years. A 1998. “The in vitro antimicrobial capacity of
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
256
results indicate that topically applied colostrum bacterial screening (vaginal or urinary) during the
may have efficacy in the prophylaxis of ophthalmia last trimester of pregnancy, approximately 75% of
neonatorum of chlamydial etiology in the absence mothers who were heavily colonized group B
of conventional modalities. streptococcus (GBS) at delivery were not detected
by this systematic screening. As is also reported in
other tropical areas where a great proportion of
Robillard, P. Y., J. M. Perez, T. C. Hulsey, J. neonatal sepsis occurs in term babies, low
Perianin, A.Gallais, and E. Janky. 2000. birthweight was not a specific risk factor in this
“Evaluation of neonatal sepsis screening in a study when controlling for other major risk factors
tropical area. Part I: Major risk factors for such as fever and premature rupture of membranes.
bacterial carriage at birth in Guadeloupe,” West Intrapartum chemoprophylaxis was associated with
Indian Med. J., vol. 49, no. 4, pp. 312–315. an approximate threefold decrease in the risk of
Abstract: This prospective study reports on GBS neonatal bacteremia among at risk deliveries.
screening for neonatal sepsis among 3,372 live The results suggest that, in our tropical context,
births out of 6,060 consecutive deliveries at the prolonged rupture of membranes of at least
University Hospital of Pointe-a-Pitre, Guadeloupe, 12 hours’ duration should be considered as a cause
during a 30-month period. Group B Streptococcus for intrapartum chemoprophylaxis as it accounted
(GBS) was the most common pathogen, for the majority of cases of neonatal bacteremia
representing 46% (89/194) of positive blood that escaped the existing protocol.
cultures and 52% (335/637) of positive gastric
aspirates. Although only 3,372 (55%) of all live
Robillard, P. Y., T. C. Hulsey, J. Perianin, J. M.
births were screened, 637 (10%) had gastric
Perez, A. Gallais, and E. Janky. 2001.
bacterial carriage at birth; of those, 335 (5.5%)
“Evaluation of neonatal sepsis screening in a
involved GBS. Similarly, there were 194 (3.2%)
tropical area Part III: Neonatal sepsis in
positive blood cultures, of which 89 (1.5%)
meconium stained deliveries,” West Indian
involved GBS. In this report, all newborns who
Med. J., vol. 50, no. 2, pp. 130–132.
presented with a positive GBS blood culture had at
least one of the external tests positive for GBS Abstract: Of the 6,060 consecutive live births
(gastric, ear canal, rectum and placenta). Thirty- delivered at the University Maternity Unit of
seven percent (14/38) of positive neonatal blood Guadeloupe (French West Indies) during a
cultures occurred in newborns with fetid liquor 30-month period, 635 newborns (10.4%) presented
while in deliveries with intrapartum fever 16.5% with meconium stained (MS) amniotic fluid, of
(32/195) of blood cultures were positive. In our which 595 (94%) received bacteriological screening
clinical practice, characteristics that were evident in at birth (light MS, n=543; thick MS, n=52). Thirty
the delivery room (without knowledge of prenatal (5%) of MS newborns had a bacteremia (n=13,
follow-up) such as fetid liquor, intrapartum fever, group B streptococcus, GBS), and 128 (21.5%) a
prolonged rupture of membranes, fetal tachycardia bacterial positive gastric aspirate (n=54, GBS).
and meconium staining were associated with the Sixty-six newborns among MS babies needed
great majority of neonatal sepsis. tracheal suctioning (11%) in the delivery room for
meconium inhalation. Among these 595 screened
MS newborns, 286 (48%) presented clinical signs
Robillard, P. Y., T. C. Hulsey, J. M. Perez, J. of postmaturity at birth, having therefore an
Perianin, A. Gallais, and E. Janky. 2001. explanation for their MS condition. For the other
“Evaluation of neonatal sepsis screening in a MS newborns without the postmaturity
NEONATAL INFECTIONS/SEPSIS
tropical area. Part II: Evaluation of intrapartum explanation, we experienced two-fold increased
chemoprophylaxis protocol,” West Indian Med. risk of neonatal sepsis (OR=1.88 for bacteremia
J., vol. 50, no. 1, pp. 37–41. and 2.61 for external carriage p<0.02, Chi-square)
Abstract: The authors report on an analysis of a as compared with their MS postmature
chemoprophylaxis protocol at the University counterparts. We conclude that when meconium
Hospital of Guadeloupe in the Caribbean. This stained deliveries are associated with postmaturity
study comprised 6,060 consecutive deliveries and signs, one may not need to initiate prophylactic
was initiated to assess the application of an antibiotic treatment at birth unless they present
intrapartum chemoprophylaxis protocol, evaluate with other traditional risk factors for neonatal
its results, and try to identify possible necessary sepsis such as intrapartum fever and prolonged
modifications to the existing protocol. Although rupture of membranes.
more than 90% of women had at least one
257
Schaller, U., d. K. Mino, S. Schriever, and V. Sinha, A., D. Yokoe, and R. Platt. 2003.
Klauss. 1997. “Ophthalmia neonatorum caused “Epidemiology of neonatal infections:
by Chlamydia trachomatis. Rapid diagnosis and experience during and after hospitalization,”
therapy,” Ophthalmologe, vol. 94, no. 5, Pediatr. Infect. Dis. J., vol. 22, no. 3,
pp. 317–320. pp. 244–251.
Abstract: BACKGROUND: In up to 73% of Abstract: OBJECTIVE: We assessed the
ophthalmia neonatorum, Chlamydia trachomatis is epidemiology of neonatal infections coming to
the causative agents. Untreated sequelae to the eyes medical attention among inpatient and outpatient
and organs may be the result. The aim of this study newborn infants within a defined health care
was to determine the bacterial spectrum of maintenance organization (HMO) population.
ophthalmia neonatorum with special regard to DESIGN AND METHODS: This was a
chlamydia and their diagnostic tests. MATERIALS retrospective cohort study, using automated data
AND METHODS: We compared the results of 15 from a large health maintenance organization and
newborn with ophthalmia neonatorum. For the the hospital where the majority of HMO patients
diagnosis we used a rapid diagnostic test, delivered. All infants delivered between October 1,
Immunofluorescent Antibody Staining and Culture 1990 and March 31, 1998 at the study hospital
on McCoy cells. Bacteria that were cultured on and receiving postdischarge care at the study HMO
culture media were also identified. RESULTS: In for the first 30 days of life were included. The
66% the newborn showed a positive rapid outcomes assessed were 10 neonatal infection
diagnostic test result that was confirmed by syndromes defined according to modified National
Immunofluorescent Antibody Staining. In five Nosocomial Infection System criteria. RESULTS:
patients all tests were negative. CONCLUSIONS: There were 13,224 infants in the study cohort. Of
In this study C. trachomatis was the most frequent these, 559 infants (4.2%) had 574 infections.
pathogen. In the culture media we isolated mostly Nonpneumonia respiratory infections were most
Gram-positive cocci but not Neisseria gonorrheae. common, accounting for 43% of all infections.
We point out the value of an exact rapid diagnosis Infections diagnosed in the outpatient setting
and specific treatment to avoid sequelae to the eye comprised 63% of all infections. More serious
and organs. infections (bloodstream infection, clinical sepsis
and pneumonia) were typically diagnosed in the
first few days of life and before nursery discharge.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
Singh, M., A. Narang, , and O. N. Bhakoo, 1994. Infants with an infection had a significantly longer
“Predictive perinatal score in the diagnosis of length of nursery stay (4.7 excess days among full
neonatal sepsis,” J. Trop. Pediatr., vol. 40, term infants, P<0.001), more office visits (397.3 vs.
no. 6, pp. 365–368. 273.3 per 100, P<0.001) and more hospital
Abstract: A scoring system for prediction of admissions (16.7 vs. 3.6 per 100, P=0.001) than
neonatal sepsis was evolved after determining the uninfected infants. CONCLUSION: Infections were
interdependence of perinatal risk factors for common during the first 30 days of life. The
infection. Records of 100 babies with a history of majority were noninvasive, were diagnosed in the
one or more perinatal risk factors were analyzed outpatient setting and were most likely community-
for incidence of infection within four hours of birth acquired. Serious infections were rare, occurred
and followed for one week thereafter for early in the neonatal period and were usually
appearance of any clinical or laboratory signs of diagnosed before nursery discharge.
infection. The incidence of sepsis was compared
amongst various risk factors. Since majority of
Stoll, B. J. 1997. “The global impact of neonatal
perinatal risk factors occur in combinations
infection,” Clin. Perinatol., vol. 24, no. 1,
interdependence of factors was determined using
pp. 1–21.
actuarial analysis and score assignment was done
whether the factor was dependent or independent. Abstract: The 1996 World Health Report
No definite infection was seen in the control group highlights the global importance of infectious
of 100 babies having no history of high risk diseases, especially among young children, and
factors. The scoring system thus elucidated is stresses the impact of new or emerging diseases.
recommended as a screening procedure for Neonatal infections are old diseases. What is
selecting of neonates for laboratory evaluation. needed is a new recognition that they are
important causes of morbidity and mortality and
that simple interventions are available that can
258
make a significant impact on the incidences of Taha, T. E., R. J. Biggar, R. L. Broadhead, L. A.
infection and death related to infection. Mtimavalye, A. B. Justesen, G. N. Liomba, J.
D. Chiphangwi, and P. G. Miotti. 1997. “Effect
of cleansing the birth canal with antiseptic
Stoll, B. J., N. Hansen, A. A. Fanaroff, L. L. solution on maternal and newborn morbidity
Wright, W. A. Carlo, R. A. Ehrenkranz, et al. and mortality in Malawi: clinical trial,” BMJ,
2002. “Changes in pathogens causing early- vol. 315, no. 7102, pp. 216–219.
onset sepsis in very-low-birth-weight infants,”
N. Engl. J. Med., vol. 347, no. 4, pp. 240–247. Abstract: OBJECTIVE: To determine if cleansing
the birth canal with an antiseptic at delivery
Abstract: BACKGROUND: It is uncertain whether reduces infections in mothers and babies
the rates and causes of early-onset sepsis (that postnatally. DESIGN: Clinical trial; two months of
occurring within 72 hours after birth) among very- no intervention were followed by three months of
low birthweight infants have changed in recent intervention and a final month of no intervention.
years, since antibiotics have begun to be used more SETTING: Queen Elizabeth Central Hospital
widely during labor and delivery. METHODS: We (tertiary care urban hospital), Blantyre, Malawi.
studied 5,447 very low birthweight infants (those SUBJECTS: A total of 6,965 women giving birth in
weighing between 401g and 1,500g) born at a six month period and their 7,160 babies.
centers of the Neonatal Research Network of the INTERVENTION: Manual wipe of the maternal
National Institute of Child Health and Human birth canal with a 0.25% chlorhexidine solution at
Development between 1998 and 2000 who had at every vaginal examination before delivery. Babies
least one blood culture in the first three days of life born during the intervention were also wiped with
and compared them with 7,606 very low chlorhexidine. MAIN OUTCOME MEASURES:
birthweight infants born at centers in the network Effects of the intervention on neonatal and
between 1991 and 1993. RESULTS: Early-onset maternal morbidity and mortality. RESULTS: 3,635
sepsis (as confirmed by positive blood cultures) was women giving birth to 3,743 babies were enrolled
present in 84 infants in the more recent birth in the intervention phase and 3,330 women giving
cohort (1.5%). As compared with the earlier birth birth to 3,417 babies were enrolled in the non-
cohort, there was a marked reduction in group B intervention phase. There were no adverse
streptococcal sepsis (from 5.9 to 1.7 per 1,000 live reactions related to the intervention among the
births of infants weighing 401g to 1,500g, mothers or their children. Among infants born in
P<0.001) and an increase in Escherichia coli sepsis the intervention phase, overall neonatal admissions
(from 3.2 to 6.8 per 1,000 live births, P=0.004); were reduced (634/3,743 (16.9%) vs. 661/3,417
the overall rate of early-onset sepsis was not (19.3%), P<0.01), as were admissions for neonatal
significantly changed. Most E. coli isolates from sepsis (7.8 vs. 17.9 per 1,000 live births,
the recent birth cohort (85%) were resistant to P<0.0002), overall neonatal mortality (28.6 vs.
ampicillin, and mothers of infants with ampicillin- 36.9 per 1,000 live births, P<0.06), and mortality
resistant E. coli infections were more likely to have due to infectious causes (2.4 v 7.3 per 1,000 live
received intrapartum ampicillin than were those births, P<0.005). Among mothers receiving the
with ampicillin-sensitive strains (26 of 28 with intervention, admissions related to delivery were
sensitivity data vs. 1 of 5, P=0.01). Infants with reduced (29.4 vs. 40.2 per 1,000 deliveries,
early-onset sepsis were more likely to die than P<0.02), as were admissions due to postpartum
uninfected infants (37% vs. 13%, P<0.001), infections (1.7 vs. 5.1 per 1,000 deliveries, P=0.02)
especially if they were infected with Gram-negative and duration of hospitalization (Wilcoxon
organisms. CONCLUSIONS: Early-onset sepsis P=0.008). CONCLUSIONS: Cleansing the birth
NEONATAL INFECTIONS/SEPSIS
remains an uncommon but potentially lethal canal with chlorhexidine reduced early neonatal
problem among very low birthweight infants. The and maternal postpartum infectious problems. The
change in pathogens over time from predominantly safety, simplicity, and low cost of the procedure
Gram-positive to predominantly Gram-negative suggest that it should be considered as standard
requires confirmation by ongoing surveillance. care to lower infant and maternal morbidity and
mortality.
259
Terrone, D. A., B. K. Rinehart, M. H. Einstein, L. 0.25–0.63. Septic shock occurred in 33 neonates
B. Britt, J. N. Martin, Jr., and K. G. Perry. within one to 36 hours of birth (mean 15 hours).
1999. “Neonatal sepsis and death caused by Among those patients, 26 (60%) died between the
resistant Escherichia coli: possible consequences fifth and the 85th hour after birth. Maternal risk
of extended maternal ampicillin factors, according to CDC criteria, included:
administration,” Am. J. Obstet. Gynecol., gestational age below 37 weeks in 26 cases (60%),
vol. 180, no. 6 Pt 1, pp. 1345–1348. amniorrhexis equal or superior to 18 hours in
seven cases (16%), and maternal temperature equal
Abstract: OBJECTIVE: Our goal was to evaluate
or superior to 38°C in four cases (9%). None of
the relationship between neonatal death caused by
the mothers had received prophylactic antibiotics
sepsis associated with ampicillin-resistant
during labor nor were urine, rectal or vaginal
organisms and length of antibiotic exposure.
swabs screened for GBS. Although the incidence of
STUDY DESIGN: All neonatal deaths from
GBS infection in the population in this study was
culture-positive sepsis over a three-year period
lower than that found in developed countries, its
were examined. Infants who were delivered at
rate of mortality was higher. The death rate could
either the University of Mississippi Medical Center
be reduced through recognition of the risk factors
or at Saint Barnabas Medical Center at
and prophylactic antibiotics during labor.
>/=24 weeks’ gestation and died within seven days
of life were included. Information on the organism
causing sepsis and its sensitivities was collected, van Bogaert, L. J. 1998. “Ophthalmia neonatorum
and the number of doses of ampicillin administered revisited,” Afr. J. Reprod. Health, vol. 2, no. 1,
to the mother before delivery was determined. pp. 81–86.
RESULTS: Of the 78 neonatal deaths, 35 met the
inclusion criteria. There were eight cases of sepsis Abstract: The microbiology, epidemiology and
from ampicillin-resistant Escherichia coli and 27 pathophysiology of ophthalmia neonatorum are
cases caused by other organisms. There was a reviewed with special emphasis on its prevention
statistically significant difference between the mean and management in the developing world.
number of doses of ampicillin received by the Although prophylaxis should be mandatory, no
ampicillin-resistant Escherichia coli group single topical agent is effective to prevent the
(17.6 +/– 5.5) compared with the other organisms ocular complications of both Neisseria gonorrhea
group (4.9 +/– 3.6) (P<.001). CONCLUSION: A and Chlamydia trachomatis. Where levels of
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
relationship exists between neonatal death caused resistance to tetracyclines are low, however,
by ampicillin-resistant Escherichia coli and tetracycline eye ointment is permissible for ocular
prolonged antepartum exposure to ampicillin. prophylaxis. Eye prophylaxis has a relatively low
failure rate. Management of ophthalmia
neonatorum should be syndromic and systemic.
Vaciloto, E. and R. Richtmann. 2002. “A survey of Contact tracing is an integral part of the
the incidence of neonatal sepsis by group B management.
streptococcus during a decade in a brazilian
maternity hospital,” Braz. J. Infect. Dis., vol. 6,
no. 2, pp. 55–62. van den Berg, R. W., H. L. Claahsen, M. Niessen,
H. L. Muytjens, K. Liem, and A. Voss. 2000.
Abstract: Group B Streptococcus (GBS) is the main “Enterobacter cloacae outbreak in the NICU
etiological agent of neonatal sepsis in developed related to disinfected thermometers,” J. Hosp.
countries, however there is no detailed information Infect., vol. 45, no. 1, pp. 29–34.
on its incidence in Brazil. We registered the
incidence and lethality of GBS infection in a Abstract: In the first week of December 1997, an
Brazilian private maternity hospital from April increasing incidence of neonates colonized with
1991 to March 2000. Maternal risk factors multi-drug resistant Enterobacter cloacae (MR-E.
contributing to neonatal infections were also cloacae) was observed in the neonatal intensive
scored. The rate of infection was determined by care unit of our 950-bed university hospital.
checking for GBS in the blood and liquor of Initially, re-enforcement of infection control
symptomatic neonates within 72 hours of birth. practices including hand disinfection and cohort
Sepsis and/or early onset meningitis were diagnosed isolation seemed to be sufficient to control the
in 43 neonates (32 cases in blood, one in liquor outbreak. Nevertheless, an increasing number of
and 10 in blood and liquor). The overall incidence newly admitted patients was paralleled by another
was 0.39 per 1,000 neonates and remained quite rise in the incidence of colonized neonates. Since E.
constant throughout the period, ranging from cloacae was initially found in urine specimens of
260
the patients, surveillance and environmental compatible with BD, and eight of these had proven
cultures were aimed at procedures and instruments BD (group B Streptococcus in five, group D
that might colonize the gastro-intestinal and/or Streptococcus in one, Shigella D in one, and
urinary tract. E. cloacae was isolated from a single Propionibacterium species in one). The two other
cap of an electronic digital thermometer. Despite febrile newborns with proven BD had no other
banning of this possible source, newly admitted symptoms of infection (group B Streptococcus and
neonates still became colonized. The unit was Escherichia coli). Mean WBC count of febrile
closed for further admissions and a second round newborns with BD was significantly lower than
of extensive screening was started; this time that of febrile newborns without BD. Only three
including all available thermometers and febrile newborns had WBC count less than
continuous rectal temperature probes. Ready-to-use 5,000/cu mm and two of them had proven BD.
“disinfected” thermometers and probes were found Febrile newborns should be evaluated and treated
to be colonized with MR-E. cloacae. Observation with antibiotics when they have symptoms of
of disinfection procedures and a laboratory infection other than fever or when the fever persists
investigation revealed that “rushed” disinfection or recurs.
with alcohol 80% led to a one in ten chance of
thermometers still being contaminated.
Furthermore, alcoholic hand rub used for Wendt, C. 2001. “Hand hygiene—comparison of
convenience disinfection failed to disinfect international recommendations,” J. Hosp.
thermometers in 40% and 20% of the cases when Infect., vol. 48 Suppl A, pp. S23–S28.
done in a “rushed” or “careful” fashion, Abstract: The value of hand hygiene for the
respectively. Adequate disinfection of the prevention of cross-infection was first observed in
thermometers led to the control of the outbreak, the middle of the 19th century. Since then, which
with no new occurrence of MR-E. cloacae in the procedure is the most suitable for hand hygiene has
following months. been repeatedly discussed and several different
guidelines and recommendations have been
published. The aim of this review is to compare
Voora, S., G. Srinivasan, L. D. Lilien, T. F. Yeh,
different recommendations for hand hygiene
and R. S. Pildes. 1982. “Fever in full-term
regarding technique and indication. Medline, the
newborns in the first four days of life,”
internet and a personal library were searched to
Pediatrics, vol. 69, no. 1, pp. 40–44.
obtain as many written recommendations as
Abstract: Over a period of 18 months, 100 full- possible. In addition, a small questionnaire was
term newborns developed an axillary or a rectal sent by e-mail to 20 international colleagues. As a
temperature greater than or equal to 37.8°C during result, written recommendations from 10 countries
the first four days of postnatal life. These febrile could be compared. Recommended methods of
term newborns represented 1% of all full-term hand hygiene include handwashing (washing hands
newborns in the normal nursery. Of the febrile with plain soap), hygienic handwash (washing
newborns, 10% had culture-proven bacterial hands with medicated soap) and hygienic hand-rub
disease (BD). Fever developed in 54%, 27%, 13%, (use of antiseptic rubs). In most countries
and 6% on the first, second, third, and fourth handwashing and hygienic handwash are the
days, respectively. In 17 newborns fever developed methods of choice and only in central European
within the first hour of life; 13 of these had countries is hygienic hand-rub the preferred
mothers with fever and two others were under a technique. Situations in which performance of
radiant warmer in the birth room. Fever occurring hand hygiene is recommended are comparable.
NEONATAL INFECTIONS/SEPSIS
on the third day of postnatal life had a significantly However, no single indication is recommended in
higher chance of being associated with BD than all guidelines. Hand hygiene is most often
fever occurring at any other time in the first four recommended before performing invasive
days of postnatal life. Newborns with temperature procedures and after microbial contamination.
greater than or equal to 39°C had a significantly Guidelines should be clear and easy to follow for
higher incidence of BD than newborns with them to become standard of care. Thus, guidelines
temperature less than 39°C. The incidence of fever are needed that do not leave to the health care
among breastfed newborns (0.98%) was similar to worker a decision as to whether hand hygiene is
that of formula-fed newborns (1.01%). Of the indicated.
100 febrile newborns, 45 had other symptoms
261
World Health Organization. 1991. Maternal and Yankauer, A. 1991. “Epidemic diarrhea of the
perinatal infections. newborn, a nosocomial problem in developing
countries,” Am. J. Public Health, vol. 81, no. 4,
Abstract: Records the results of a WHO
pp. 415–417.
consultation convened to evaluate the public health
significance of maternal and perinatal infections in
developing countries, assess the adequacy of tools
for their prevention and treatment, and propose
realistic strategies for control. The objective is to
help health officials identify the most rational and
humane approach to the control of these major
causes of morbidity and mortality. In view of the
meagre resources available for health care, a
particular effort is made to determine the
feasibility, effectiveness, and average costs of all
possible interventions.
Available at:
http://www.who.int/dsa/cat98/mat8.htm#Maternal
andPerinatalInfections
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
262
Mother-to-Child Transmission of HIV/AIDS
Biberfeld, G., F. Buonaguro, A. Lindberg, T. G. de, were ruptured more than four hours before
Z. Yi, and R. Zetterstrom. 2002. “Prospects of delivery (transmission 25% in the intervention
vaccination as a means of preventing mother-to- group vs. 39% in the control group).
child transmission of HIV-I,” Acta Paediatr., INTERPRETATION: If birth canal exposure is an
vol. 91, no. 2, pp. 241–242. important risk factor, different or additional
methods to reduce the risk of perinatal HIV
Abstract: Although short-course antiretroviral
transmission should be tested. Alternatively,
therapy is efficient in reducing mother-to-child
perhaps birth canal exposure is not a major
transmission (MTCT) of HIV-1, it does not prevent
contributor to perinatal infection risk.
transmission during the breastfeeding period. There
is therefore an urgent need to test various
approaches, including HIV-1 vaccination, to try to Bobat, R., D., Moodley, A. Coutsoudis, and H.
prevent postnatal transmission of HIV-1 in Coovadia. 1997. “Breastfeeding by HIV-1-
breastfeeding populations in developing countries. infected women and outcome in their infants: a
cohort study from Durban, South Africa,”
AIDS, vol. 11, no. 13, pp. 1627–1633.
Biggar, R. J., P. G. Miotti, T. E. Taha, L.
Mtimavalye, R. Broadhead, A. Justesen, F. Abstract: BACKGROUND: Women in developing
Yellin, G. Liomba, W. Miley, D. Waters, J. D. countries have the difficult choice of balancing the
Chiphangwi, and J. J. Goedert. 1996. “Perinatal risk of transmitting HIV through breastmilk
intervention trial in Africa: effect of a birth against the substantial benefits of breastfeeding. It
canal cleansing intervention to prevent HIV is not known, however, whether the benefits of
transmission,” Lancet, vol. 347, no. 9016, breastfeeding are the same when the mother is
pp. 1647–1650. HIV-infected. Therefore, we examined the impact
of breastfeeding on infections, growth and
Abstract: BACKGROUND: Perinatal transmission
mortality in the infants of HIV-1-infected women.
of human immunodeficiency virus (HIV) type one
METHODS: Infants of HIV-1-positive women were
contributes significantly to infant mortality.
followed from birth and at each visit they were
Exposure in the birth canal may account for some
examined, growth parameters were recorded and
transmission. We examined the efficacy of a birth
notes were made of feeding method, and of current
canal washing procedure in reducing perinatal
and interim illnesses. RESULTS: Of the 43 HIV-
transmission in Malawi. METHODS: The infection
infected and 90 non-infected infants for whom
status of infants of 3,327 control women
feeding data were available, 36 infants (27%) were
263
those on mixed feeds and 0% in those exclusively values values were associated with an increased
formula-fed. The frequency of failure to thrive and risk of transmission. Twelve months could be used
episodes of diarrhea and pneumonia were not as the cutoff age for the diagnosis of vertical
significantly different between the three groups in infection using antibody tests.
both the infected and non-infected infants.
CONCLUSIONS: Exclusive breastfeeding by HIV-
infected women does not appear to protect their Brocklehurst, P. 2002. Interventions aimed at
infants against common childhood illnesses and decreasing the risk of mother-to-child
failure to thrive, nor does it significantly delay transmission of HIV infection.
progression to AIDS. The implication of the trend Abstract: At the end of 1998 over 33 million
towards differential mortality rates according to people were infected with the human
feeding groups is uncertain and requires further immunodeficiency virus (HIV) and over one
investigation. million children had been infected from their
mothers. The objective of this review was to assess
what interventions may be effective in decreasing
Bobat, R., H. Coovadia, A. Coutsoudis, and D.
the risk of mother-to-child transmission of HIV
Moodley. 1996, “Determinants of mother-to-
infection as well as their effect on neonatal and
child transmission of human immunodeficiency
maternal mortality and morbidity. The Cochrane
virus type 1 infection in a cohort from Durban,
Pregnancy and Childbirth Group trials register and
South Africa,” Pediatr. Infect. Dis. J., vol. 15,
the Cochrane Controlled Trials Register were
no. 7, pp. 604–610.
searched. Randomized trials comparing any
Abstract: OBJECTIVES: To determine the vertical intervention aimed at decreasing the risk of
transmission rate of HIV-1 infection and to assess mother-to-child transmission of HIV infection
the influence of maternal risk factors on compared with placebo or no treatment, or any
transmission in infants born to HIV-1-infected two or more interventions aimed at decreasing the
black women in Durban. DESIGN: A prospective, risk of mother-to-child transmission of HIV
hospital-based cohort study conducted at King infection. Trial quality assessments and data
Edward VIII hospital, Durban. HIV-1-seropositive extraction were undertaken by the reviewer.
women were enrolled into the study, and their
Main results:
infants were followed up at regular intervals from
Zidovudine—Four trials comparing zidovudine
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
264
Immunoglobulin—One trial comparing cohort studies of HIV-positive and HIV-negative
hyperimmune immunoglobulin plus zidovudine pregnant women that attempt to control for
with non-specific immunoglobulin plus zidovudine confounding. Ideally, these studies would collect
involving 501 participants was included. The data on immune function and HIV disease stage
addition of hyperimmune immunoglobulin to before and during pregnancy, enroll women in the
zidovudine does not appear to have any additional early antenatal stages, and follow-up for at least a
effect on the risk of mother-to-child transmission year after delivery.
(RR=0.67, 95% CI: 0.29–1.55).
Reviewers’ conclusions: Zidovudine, nevirapine Casalini, C., L. Signorini, A., Beltrame, A.
and delivery by elective cesarean section appear to Matteelli, and G. Carosi. 2001. “Vertical
be very effective in decreasing the risk of mother- transmission of human immunodeficiency virus
to-child transmission of HIV infection. (HIV) and other sexually transmitted infections
(STI),” Minerva Ginecol. , vol. 53, no. 3,
pp. 177–192.
Brocklehurst, P. and R. French. 1998. The
association between maternal HIV infection Abstract: Infectious agents which are sexually
and perinatal outcome: a systematic review of transmitted determine considerable morbidity in
the literature and meta-analysis. women during the gestational period. Connatal
and perinatal infection of the newborn,
Abstract: The association between maternal HIV
miscarriage, and low birthweight have all been
infection and perinatal outcome was evaluated
described. Vertical transmission of HIV and other
through a systematic literature review and a meta-
STD may occur via the placenta during gestation
analysis of the studies located. The review of the
(the major mechanism for syphilis) or at birth
literature for the period 1983–1996 identified
during the passage through the cervico-vaginal
31 prospective studies with an appropriate control
channel (the major mechanism for HIV, HBV, HSV,
group (21 conducted in developing countries) on
gonorrhea and chlamydia). High serum viral loads
this topic. The summary odds ratios (ORs) of the
of HIV significantly increase the likelihood of
risk of adverse perinatal outcomes related to
newborn infection, while the presence of lesions in
maternal HIV infection were as follows:
the genital tract at birth increases the odd for
spontaneous abortion, 4.05 (95% confidence
transmission for HSV. Breastfeeding is a well
interval (CI): 2.75–5.96); stillbirth, 3.91 (95% CI:
described route of transmission for HIV infection,
2.65–5.77); fetal abnormality, 1.08 (95% CI:
but it is irrelevant to the transmission of HBV.
0.7–1.66); perinatal mortality, 1.79 (95% CI:
Cutaneous lesions of the breast and nipples carry a
1.14–2.81); neonatal mortality, 1.10 (95% CI:
risk of transmission of syphilis and HSV through
0.63–1.93); infant mortality, 3.69 (95% CI:
breastfeeding. Treatment of the etiologic agent is
3.03–4.49); intrauterine growth retardation, 1.7
considered an effective means for the prevention of
(95% CI: 1.43–2.02); low birthweight, 2.09 (95%
265
HBV infection do not require etiologic treatment; these findings are currently being implemented in
however, their newborns should receive several African countries. Prevention of the MTCT
concomitant doses of HBV immunoglobulins and of HIV should also be considered as part of the
HBV vaccine soon after birth. Standard practices of wider management of maternal and infant health
prevention of vertical transmission of STI agents during prenatal, delivery and postnatal care.
applies to women regardless their native country. Several complementary issues require further
However, the feasibility of implementation of the investigation. Some results, such as the long-term
guidelines in poor resource countries is a matter of efficacy of a short course of ARVs once the mother
great concern: an unresolved debate is ongoing on has finished breastfeeding, and the long-term safety
optimal strategies for the prevention of vertical of these treatments, require confirmation. Further
transmission of HIV in such countries. studies are required into the prevention of
postnatal transmission, particularly in light of the
unknown consequences of different feeding options
Castetbon, K., V. Leroy, R. Spira, and F. Dabis. and the possibility of post-perinatal prophylaxis
2000. “Preventing the transmission of HIV-1 with ARVs. The reduction of MTCT of HIV in
from mother to child in Africa in the year Africa is a true challenge in efforts to control the
2000,” Santé, vol. 10, no. 2, pp. 103–113. HIV pandemic, but recent progress in the
Abstract: African women of childbearing age are identification of effective treatments provides some
particularly vulnerable to HIV infection, and this hope. Large-scale implementation of these new
has led to an increase in the number of pediatric treatments is required, and should provide practical
HIV infections reported due to the risk of mother- information and perhaps identify more potent, and
to-child transmission (MTCT) of HIV during possibly cheaper, strategies.
pregnancy, delivery and breastfeeding. Various
approaches to preventing MTCT have been, or are
Ceballos, A., P. M. Los Angeles, D. Liberatore, M.
being, evaluated in developing countries, especially
Biglione, P. C. Cardenas, M. Martinez, M. L.
in Africa. New data from these trials are becoming
Celadilla, M. M. Avila, and L. M. Peralta.
available and have implications for population-
2002. “Efficacy of strategies to reduce mother-
based intervention programs that require urgent
to-child HIV-1 transmission in Argentina,
consideration. We performed a critical review of
1993–2000,” J. Acquir. Immune. Defic. Syndr.,
18 randomized trials and other relevant studies
vol. 31, no. 3, pp. 348–353.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
266
drug use (67%). These results point out the urgent Coutsoudis, A. 2000. “Promotion of exclusive
need to develop additional strategies for prevention breastfeeding in the face of the HIV pandemic,”
of MTCT of HIV-1 to generalize education, Lancet, vol. 356, no. 9242, pp. 1620–1621.
counseling, and testing of young women.
Abstract: This paper is a commentary on the issue
of promoting exclusive breastfeeding in the face of
Chopra, M., E. Piwoz, J. Sengwana, N. Schaay, L. the HIV-1 pandemic. It notes that in the
Dunnett, and D. Saders. 2002. “Effect of a randomized study by Rukhsana Haider and
mother-to-child HIV prevention program on colleagues showing the impact of using peer
infant feeding and caring practices in South counselors to promote exclusive breastfeeding in
Africa,” S. Afr. Med. J., vol. 92, no. 4, Dhaka, Bangladesh, a significant improvement in
pp. 298–302. the percentage of women in the intervention group,
who were exclusively breastfeeding at five months,
Abstract: OBJECTIVES: To conduct a rapid was indicated. This implies that it is possible to
assessment of the impact of the Khayelitsha bring about change in breastfeeding practice that is
Prevention of Mother-to-Child Transmission important for HIV-1-infected women who
(MTCT) program on infant care practices among breastfeed. Hence, although many would argue
program participants and the local population. that breastfeeding might increase HIV
STUDY DESIGN: Cross-sectional survey and transmission, it can be promoted, provided that
qualitative in-depth interviews. SETTING. counselors inform mothers that if they have or are
Khayelitsha, a large formal and informal settlement at risk of HIV-1 infection, they should seek advice
of about 300,000 people on the outskirts of Cape on infant-feeding from an HIV counselor; they
Town. At the time of the study the HIV should use condoms during the lactation period;
seroprevalence rate among antenatal women was and they should seek prompt treatment for any
about 15% and the MTCT program had enrolled breast abnormality or for oral thrush in the infant.
nearly 800 infected women. SUBJECTS: Seventy
randomly selected caregivers with young children
in the survey; in-depth structured interviews with Coutsoudis, A., A. Goga, N. Rollins, and H.
11 nutrition counselors and 11 mothers enrolled in Coovadia. 2002. “Free formula milk for infants
the program. RESULTS: Caregivers have good of HIV-infected women: blessing or curse?”
knowledge of the spread and prevention of HIV. A Health Policy Plan., vol. 17, no. 2,
majority knew that breastfeeding can transmit HIV pp. 154–160.
but 90% stated that this did not affect their feeding
Abstract: There is vigorous controversy around
decisions. Over 80% had stopped exclusively
whether HIV-infected women in developing
breastfeeding by the time their infants were three
countries should choose formula or breastfeeding
months of age. All of the respondents felt that
for their infants. Formula eliminates HIV
being diagnosed HIV-positive would result in
transmission but incurs risk of increased mortality,
267
“spill-over” effect into the normal breastfeeding require urgent review. If our findings are confirmed,
population. Recommendations to minimize these exclusive breastfeeding may offer HIV-1-infected
drawbacks include use of affordable antiretrovirals women in developing countries an affordable,
to reduce MTCT; investments in high-quality, culturally acceptable, and effective means of
widely available HIV counseling; support for reducing mother-to-child transmission of HIV-1
choice of feeding; and exclusive breastfeeding for while maintaining the overwhelming benefits of
those who choose to breastfeed. breastfeeding.
Coutsoudis, A., K. Pillay, E. Spooner, L. Kuhn, and Coutsoudis, A., K. Pillay, E. Spooner, L. Kuhn, and
H. M. Coovadia. 1999. “Influence of infant- H. M. Coovadia. 1999. “Randomized trial
feeding patterns on early mother-to-child testing the effect of vitamin A supplementation
transmission of HIV-1 in Durban, South Africa: on pregnancy outcomes and early mother-to-
a prospective cohort study. South African child HIV-1 transmission in Durban, South
Vitamin A Study Group,” Lancet, vol. 354, Africa. South African Vitamin A Study Group,”
no. 9177, pp. 471–476. AIDS, vol. 13, no. 12, pp. 1517–1524.
Abstract: BACKGROUND: The observation that Abstract: OBJECTIVE: Poor vitamin A status has
mother-to-child transmission of HIV-1 can occur been associated with a higher risk for mother-to-
through breastfeeding has resulted in policies that child transmission of HIV-1 and there is
recommend avoidance of breastfeeding by HIV-1- contradictory evidence on the impact of vitamin A
infected women in the developed world and under on perinatal outcome. We therefore assessed the
specific circumstances in developing countries. We effect of vitamin A supplementation to mothers on
compared transmission rates in exclusively birth outcome and mother-to-child transmission of
breastfed, mixed-fed, and formula-fed (never HIV-1. DESIGN AND METHODS: In Durban,
breastfed) infants to assess whether the pattern of South Africa 728 pregnant HIV infected women
breastfeeding is a critical determinant of early received either vitamin A (368) or placebo (360) in
mother-to-child transmission of HIV-1. METHODS: a randomized, double-blind trial. The vitamin A
We prospectively assessed infant-feeding practices of treatment consisted of a daily dose of 5,000 IU
549 HIV-1-infected women who were part of a retinyl palmitate and 30mg beta-carotene during
vitamin A intervention trial in Durban, South the third trimester of pregnancy and 200,000 IU
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
Africa. The proportions of HIV-1-infected infants at retinyl palmitate at delivery. HIV infection results
three months (estimated by use of Kaplan-Meier life were available on 632 children who were included
tables) were compared in the three different feeding in the Kaplan-Meier transmission analysis. Results
groups. HIV-1 infection was defined by a positive are reported on mother-to-child transmission rates
RNA-PCR test. FINDINGS: At three months, up to three months of age. RESULTS: There was
18.8% (95% CI: 12.6–24.9) of 156 never-breastfed no difference in the risk of HIV infection by three
children were estimated to be HIV-1 infected months of age between the vitamin A [20.3%;
compared with 21.3% (17.2–25.5) of 393 breastfed 95% confidence interval (CI): 15.7–24.9] and
children (p=0.5). The estimated proportion (Kaplan- placebo groups (22.3%; 95% CI: 17.5–27.1), nor
Meier) of infants HIV-1 infected by three months were there differences in fetal or infant mortality
was significantly lower for those exclusively rates between the two groups. Women receiving
breastfed to three months than in those who vitamin A supplement were, however, less likely to
received mixed feeding before three months (14.6% have a preterm delivery (11.4% in the vitamin A
[7.7–21.4] vs. 24.1% [19.0–29.2], p=0.03). After and 17.4% in the placebo group; P=0.03) and
adjustment for potential confounders (maternal among the 80 preterm deliveries, those assigned to
CD4-cell/CD8-cell ratio, syphilis screening test the vitamin A group were less likely to be infected
results, and preterm delivery), exclusive (17.9%; 95% CI: 3.5–32.2) than those assigned to
breastfeeding carried a significantly lower risk of the placebo group (33.8%; 95% CI: 19.8–47.8).
HIV-1 transmission than mixed feeding (hazard CONCLUSION: Vitamin A supplementation, a
ratio 0.52 [0.28–0.98]) and a similar risk to no low-cost intervention, does not appear to be
breastfeeding (0.85 [0.51–1.42]). effective in reducing overall mother-to-child
INTERPRETATIONS: Our findings have important transmission of HIV; however, its potential for
implications for prevention of HIV-1 infection and reducing the incidence of preterm births, and the
infant-feeding policies in developing countries and risk of mother-to-child transmission of HIV in
further research is essential. In the meantime, these infants needs further investigation.
breastfeeding policies for HIV-1-infected women
268
Coutsoudis, A., K. Pillay, L. Kuhn, E. Spooner, W. Abstract: OBJECTIVES: Different approaches to
Y. Tsai, and H. M. Coovadia. 2001. “Method prevent mother-to-child transmission of HIV are
of feeding and transmission of HIV-1 from being evaluated in developing countries. The first
mothers to children by 15 months of age: trials using a short regimen of zidovudine have
prospective cohort study from Durban, South been successful in Thailand, Cote d’Ivoire and
Africa,” AIDS, vol. 15, no. 3, pp. 379–387. Burkina Faso. International and local strategies are
now being considered. The Ghent International
Abstract: OBJECTIVE: To determine the risk of
Working Group on Mother-to-Child Transmission
HIV transmission by infant feeding modality.
of HIV developed public health policy options to
DESIGN AND SETTING: A prospective study in
integrate these interventions into basic and
two hospitals in Durban, South Africa.
maternal and child health (MCH) services.
PARTICIPANTS: A total of 551 HIV-infected
METHODS: The following tasks were undertaken:
pregnant women enrolled in a randomized trial of
a critical review of randomized trials; an
vitamin A. INTERVENTIONS: Women self-
international pooled analysis of late postnatal
selected to breastfeed or formula feed after being
transmission of HIV through breastfeeding; a
counselled. Breastfeeders were encouraged to
review of the cost-effectiveness and cost-benefit of
practice exclusive breastfeeding for three to six
antiretroviral prophylaxis; a feasibility assessment
months. MAIN OUTCOME MEASURES:
of preventive strategies, including a postal survey
Cumulative probabilities of detecting HIV over
on HIV voluntary counseling and testing (VCT) of
time were estimated using Kaplan-Meier methods
pregnant women; the identification of requirements
and were compared in three groups: 157 formula-
and research priorities for prenatal, obstetric and
fed (never breastfed); 118 exclusively breastfed for
pediatric care. These projects provided the
three months or more; and 276 mixed breastfed.
background for a three-day workshop in Ghent,
RESULTS: The three feeding groups did not differ
Belgium, in November 1997. Conclusions were
in any risk factors for transmission, and the
further refined, based on 1998 research findings.
probability of detecting HIV at birth was similar.
RESULTS: A summary of relevant evidence and ten
Cumulative probabilities of HIV detection
public health recommendations are reported. VCT
remained similar among never and exclusive
for pregnant women, a short regimen of zidovudine
breastfeeders up to six months: 0.194 (95% CI:
together with alternatives to breastfeeding currently
0.136–0.260) and 0.194 (95% CI: 0.125–0.274),
represent the best option to reduce vertical
respectively, whereas the probabilities among
transmission in most developing countries. The
mixed breastfeeders soon surpassed both groups
primary goal of the integrated package supporting
reaching 0.261 (95% CI: 0.205–0.319) by six
these interventions is to alleviate overall maternal
months. By 15 months, the cumulative probability
and infant morbidity and mortality.
of HIV infection remained lower among those who
CONCLUSION: Prevention of mother-to-child
exclusively breastfed for three months or more
transmission of HIV should now be considered for
than among other breastfeeders (0.247 versus
integration into basic health and MCH services of
269
predominant mode of infant feeding. This article De Cock, K. M., M. G. Fowler, E. Mercier, V. I. de,
reviews major accomplishments in this area, J. Saba, E. Hoff, D. J. Alnwick, M. Rogers, and
outlines practical issues for program N. Shaffer. 2000. “Prevention of mother-to-
implementation, and suggests future research child HIV transmission in resource-poor
needs. Short-course zidovudine and short-course countries: translating research into policy and
nevirapine in the peripartum period currently practice,” JAMA, vol. 283, no. 9,
represent two valid options to reduce MTCT of pp. 1175–1182.
HIV in developing countries if appropriate
Abstract: Each year, an estimated 590,000 infants
prenatal, obstetrical, and postnatal care is provided
acquire human immunodeficiency virus type one
and if alternatives to breastfeeding are considered
(HIV) infection from their mothers, mostly in
according to the local situation and the mother’s
developing countries that are unable to implement
individual decision.
interventions now standard in the industrialized
world. In resource-poor settings, the HIV pandemic
Dabis, F., V. Leroy, K. Castetbon, R. Spira, M. L. has eroded hard-won gains in infant and child
Newell, and R. Salamon. 2000. “Preventing survival. Recent clinical trial results from
mother-to-child transmission of HIV-1 in Africa international settings suggest that short-course
in the year 2000,” AIDS, vol. 14, no. 8, antiretroviral regimens could significantly reduce
pp. 1017–1026. perinatal HIV transmission worldwide if research
findings could be translated into practice. This
Abstract: OBJECTIVES: Various approaches to article reviews current knowledge of mother-to-
preventing mother-to-child transmission (MTCT) child HIV transmission in developing countries,
of HIV have recently been, or are being, evaluated summarizes key findings from the trials, outlines
in developing countries, especially in Africa. New future research requirements, and describes public
findings from these trials are now becoming health challenges of implementing perinatal HIV
available, the implications of which, for prevention interventions in resource-poor settings.
population-based intervention programs, need Public health efforts must also emphasize primary
urgent consideration. METHOD: A critical review prevention strategies to reduce incident HIV
of 18 randomized trials and other relevant studies infections among adolescents and women of
from developing and industrialized countries. childbearing age. Successful implementation of
RESULTS: Most African results relate to trials of available perinatal HIV interventions could
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
antiretroviral agents (ARV). They demonstrate substantially improve global child survival.
efficacy in reducing transmission in the first six
months of life with short regimens of zidovudine
(ZDV), with or without lamivudine (3TC), and de Paoli, M., R. Manongi, E. Helsing, and K. I.
nevirapine (NVP) alone. Preliminary results suggest Klepp. 2001. “Exclusive breastfeeding in the era
the long-term efficacy of zidovudine. Antiseptic of AIDS,” J. Hum. Lact., vol. 17, no. 4,
and nutritional interventions have been shown to pp. 313–320.
reduce maternal and infant mortality and
Abstract: The aim of this study was to describe
morbidity but not MTCT of HIV. HIV confidential
breastfeeding practices, as well as what pregnant
voluntary counseling and testing for pregnant
women know about breastfeeding and mother-to-
women, a short regimen of peripartum ARV with
child transmission (MTCT) of HIV, and explore
alternatives to breastfeeding such as early weaning
factors associated with exclusive breastfeeding,
or breastmilk substitutes from birth currently
especially in the presence of HIV/AIDS. A cross-
represent the best option to reduce MTCT of HIV
sectional interview survey of 500 pregnant women
in Africa. However, the prevention of postnatal
was conducted in the Kilimanjaro region,
transmission requires further research, particularly
supplemented by focus group discussions with
in view of the consequences of different feeding
pregnant women. Among the 309 mothers having
options and the possibility of post-perinatal
previously breastfed, 85% had initiated
exposure prophylaxis of newborns with ARV.
breastfeeding within the first few hours
Issues relating to the implementation of currently
postpartum, and 18% of newborns received some
validated strategies are discussed.
prelacteal food. Mean duration of breastfeeding
was 23.7 months, but 46% of mothers had
270
introduced other fluids early. Knowledge of HIV- Dorenbaum, A., C. K. Cunningham, R. D. Gelber,
transmission through breastfeeding was not M. Culnane, L. Mofenson, P. Britto, C.
associated with breastfeeding practices. Married Rekacewicz, M. L. Newell, J. F. Delfraissy, B.
women (odds ratio [OR]=.09, 95% confidence Cunningham-Schrader, M. Mirochnick, and J.
interval [CI]: .04–.24) and those having knowledge L. Sullivan. 2002. “Two-dose
of exclusive breastfeeding (OR=.08, intrapartum/newborn nevirapine and standard
95% CI: .02–.31) were the least likely to end antiretroviral therapy to reduce perinatal HIV
exclusive breastfeeding early. Exclusive transmission: a randomized trial,” JAMA,
breastfeeding is a rare practice, and MTCT of HIV vol. 288, no. 2, pp. 189–198.
may further complicate recommendations with
Abstract: CONTEXT: A two-dose
regard to this practice.
intrapartum/newborn nevirapine regimen reduced
perinatal human immunodeficiency virus (HIV)
Desclaux, A. 2002. “What if the HIV/AIDS transmission in Ugandan women not receiving
pandemic were an opportunity to improve the antenatal antiretroviral therapy (ART). However, it
relevance of breastfeeding promotion programs is unknown whether the addition of the two-dose
in Africa?” Santé, vol. 12, no. 1, pp. 73–75. nevirapine regimen to standard ART would further
reduce perinatal HIV transmission. OBJECTIVE:
Abstract: In the 1990s, many programs and To determine whether a two-dose nevirapine
actions were set up for promoting breastfeeding in regimen can decrease perinatal transmission of HIV
Africa, more or less successfully in different in nonbreastfeeding women receiving standard
countries. The main achievements of these ART. DESIGN AND SETTING: International,
programs were the training of health professionals blinded, placebo-controlled, phase three trial
and the apparent ending of the distribution of enrolling women between May 1997 and June
formula in health services. The impact of these 2000 at clinical sites providing care for HIV
programs on breastfeeding practices in countries infection throughout the United States, Europe,
with prevalent prolonged mixed feeding is less Brazil, and the Bahamas. PARTICIPANTS: A total
obvious, as many programs did not emphasize of 1,270 women received nevirapine (n=642) or
“best practices.” Health messages delivered on this placebo (n=628). Infants were followed up for six
topic have been poor, because they were often months to determine HIV-infection status, which
conceived at the international level rather than was available for 1,248 deliveries.
adapted to African contexts, and because the INTERVENTION: A 200mg dose of oral
consensus about the promotion of breastfeeding is nevirapine to women after onset of labor and a
so strong that the programs have rarely undergone 2mg/kg dose of oral nevirapine to newborns
a critical evaluation. The HIV/AIDS pandemic between 48 and 72 hours after birth. MAIN
could be an opportunity to rethink these OUTCOME MEASURES: Detection of HIV
programs. “Baby friendly” health services are now infection in infants and grade three and four toxic
271
higher delivery HIV RNA levels, but there was no age at birth by 43% (0.57 [0.39–0.82], p=0.002).
significant difference between treatment arms in Vitamin A supplementation had no significant
any subgroup. CONCLUSION: Risk of perinatal effect on these variables. Multivitamins, but not
HIV transmission was low and no benefit from vitamin A, resulted in a significant increase in
additional intrapartum/newborn nevirapine was CD4, CD8, and CD3 counts. INTERPRETATION:
demonstrated when women received prenatal care Multivitamin supplementation is a low-cost way of
and antenatal ART, and elective cesarean section substantially decreasing adverse pregnancy
was made available. outcomes and increasing T-cell counts in HIV-1-
infected women. The clinical relevance of our
findings for vertical transmission and clinical
Family Health International. 2001. Reducing progression of HIV-1 disease is yet to be
mother-to-child transmission of HIV: a ascertained.
strategic framework.
Abstract: Strategies drawing from current scientific
Gaillard, P., C. Verhofstede, F. Mwanyumba, P.
knowledge and collective international experience
Claeys, V. Chohan, K. Mandaliya, J. Bwayo, J.
that can be implemented as part of a
Plum, and M. Temmerman. 2000. “Exposure to
comprehensive program to reduce mother-to-child
HIV-1 during delivery and mother-to-child
transmission of HIV.
transmission,” AIDS, vol. 14, no. 15,
Available at: pp. 2341–2348.
http://www.fhi.org/NR/rdonlyres/ebriuecrw6buidkq
Abstract: BACKGROUND: The correlation
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between the presence of HIV-1 in maternal
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cervicovaginal secretions and in the infant’s oro-
pharyngal secretions at birth, and mother-to-child
Fawzi, W. W., G. I. Msamanga, D. Spiegelman, E. HIV transmission (MTCT) were examined to
J. Urassa, N. McGrath, D. Mwakagile, G. obtain a better understanding of its mechanism.
Antelman, R. Mbise, G. Herrera, S. Kapiga, W. METHODS: Women without medical and
Willett, and D. J. Hunter. 1998. “Randomized obstetrical complications, living within a
trial of effects of vitamin supplements on reasonable distance of the government hospital in
pregnancy outcomes and T cell counts in HIV- Mombasa, Kenya, were recruited after informed
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
1-infected women in Tanzania,” Lancet, consent. Maternal and infant characteristics were
vol. 351, no. 9114, pp. 1477–1482. collected. Polymerase chain reaction was used to
detect HIV-1 in cervico-vaginal and oro-pharyngal
Abstract: BACKGROUND: In HIV-1-infected secretions. Infants were tested for HIV-1 by
women, poor micronutrient status has been polymerase chain reaction within 48 hours and at
associated with faster progression of HIV-1 disease six weeks after delivery. RESULTS: Between April
and adverse birth outcomes. We assessed the effects 1998 and April 1999, 228 woman-infant pairs
of vitamin A and multivitamins on birth outcomes were included in the study. HIV-1 DNA in cervico-
in such women. METHODS: In Tanzania, vaginal secretions was independently associated
1,075 HIV-1-infected pregnant women at between with HIV-1 maternal viral load and with infant
12 and 27 weeks’ gestation received placebo birthweight, whereas HIV-1 RNA was associated
(n=267), vitamin A (n=269), multivitamins with maternal viral load and maternal age. HIV-1
excluding vitamin A (n=269), or multivitamins DNA in the oropharyngal secretions was also
including vitamin A (n=270) in a Randomized, independently associated with maternal viral load.
double-blind, placebo-controlled trial with a 2x2 MTCT rate at the age of six weeks was 23.6%.
factorial design. We measured the effects of Intrapartum and early postpartum HIV
multivitamins and vitamin A on birth outcomes transmission was independently associated with
and counts of T-lymphocyte subsets. We did maternal viral load [adjusted odds ratio (OR)=1.6;
analyses by intention to treat. RESULTS: Thirty 95% confidence interval (CI): 1.0–2.7], detection
fetal deaths occurred among women assigned of HIV-1 RNA in cervico-vaginal secretions
multivitamins compared with 49 among those not (adjusted OR=3.2; 95% CI: 1.5–7.3) and of HIV-1
on multivitamins (relative risk=0.61 [95% CI: DNA in oro-pharyngeal secretions (adjusted
0.39–0.94] p=0.02). Multivitamin supplementation OR=3.2; 95% CI: 1.1–9.0). DISCUSSION: As far
decreased the risk of low birthweight (<2,500g) by as is known, this is the first study showing that
44% (0.56 [0.38–0.82], p=0.003), severe preterm infant exposure to HIV-1 in the birth canal and the
birth (<34 weeks of gestation) by 39% (0.61 presence of HIV-infected cells in the infant’s
[0.38–0.96], p=0.03), and small size for gestational
272
oropharyngeal cavity are independently associated Gaillard, P., F. Mwanyumba, C. Verhofstede, P.
with intrapartum and early postpartum MTCT. It Claeys, V. Chohan, E. Goetghebeur, K.
supports the hypothesis that MTCT could occur Mandaliya, J. Ndinya-Achola, and M.
through the oral route. Temmerman. 2001. “Vaginal lavage with
chlorhexidine during labor to reduce mother-to-
child HIV transmission: clinical trial in
Gaillard, P., E. Piwoz, and T. M. Farley. 2001. Mombasa, Kenya,” AIDS, vol. 15, no. 3,
“Collection of standardized information on pp. 389–396.
infant feeding in the context of mother-to-child
transmission of HIV,” Stat. Med., vol. 20, Abstract: OBJECTIVES: To evaluate the effect of
no. 23, pp. 3525–3537. vaginal lavage with diluted chlorhexidine on
mother-to child transmission of HIV (MTCT) in a
Abstract: Complete avoidance of breastfeeding is breastfeeding population. METHODS: This
the surest way to avoid mother-to-child prospective clinical trial was conducted in a
transmission (MTCT) of HIV through governmental hospital in Mombasa, Kenya. On
breastfeeding, but replacement feeding exposes alternating weeks, women were allocated to non-
infants, especially those born in developing intervention or to intervention consisting of vaginal
countries, to the risk of other infectious diseases lavage with 120ml 0.2% chlorhexidine, later
with consequent increase in morbidity and increased to 0.4%, repeated every three hours from
mortality. One study has suggested that exclusive admission to delivery. Infants were tested for HIV
breastfeeding during the first months of life carries by DNA polymerase chain reaction within
a lower risk of HIV transmission than when other 48 hours and at six and 14 weeks of life.
foods are given in addition to breastmilk. Other RESULTS: Enrollment and follow-up data were
studies have provided limited data on the risks of available for 297 and 309 HIV-positive women,
HIV transmission according to different patterns of respectively, in the non-lavage and the lavage
breastfeeding, but studies have used different groups. There was no evidence of a difference in
definitions of breastfeeding patterns and have intrapartum MTCT (17.2 versus 15.9%, OR=0.9,
analyzed their data with adjustment on different 95% CI: 0.6–1.4) between the groups. Lavage
risk factors. This hampers our ability to understand solely before rupture of the membranes tended
the mechanisms underlying HIV transmission towards lower MTCT with chlorhexidine 0.2%
through breastmilk and the risks associated with (OR=0.6, 95% CI: 0.3–1.1), and even more with
different infant feeding practices. Consequently it is chlorhexidine 0.4% (OR=0.1, 95% CI: 0.0–0.9).
difficult to determine the best interventions to CONCLUSION: The need remains for
reduce the risk of transmission and the interventions reducing MTCT without HIV testing,
development of optimal policies. In collaboration often unavailable in countries with a high
with research teams involved with infant feeding prevalence of HIV. Vaginal lavage with diluted
research, the World Health Organization has chlorhexidine during delivery did not show a
group), 48 received the reduced Berlin prophylaxis breastfed, and 95.6% were still breastfeeding at age
regimen, 18 received combination therapy and nine 14–16 weeks. The estimated risks of HIV-1
received only part of the prophylaxis regimen. Of transmission in the zidovudine and nevirapine
the antiretroviral group, 68 were delivered by groups were: 10.4% and 8.2% at birth (p=0.354);
elective cesarean section. The HIV transmission 21.3% and 11.9% by age six to eight weeks
rate was zero in the antiretroviral group (p=0.0027); and 25.1% and 13.1% by age
[95% confidence interval (CI): 0–4.7] and 14–16 weeks (p=0.0006). The efficacy of nevirapine
12.6% (6.4–19.0) in the control group. The compared with zidovudine was 47% (95% CI:
reduction in vertical transmission was 90% for the 20–64) up to age 14–16 weeks. The two regimens
Berlin regimen, with an 80% and 70% reduction were well tolerated and adverse events were similar
in risk associated with antiretroviral treatment and in the two groups. INTERPRETATION: Nevirapine
cesarean section, respectively. Maternal CD4 cell lowered the risk of HIV-1 transmission during the
count but not viral load had some confounding first 14–16 weeks of life by nearly 50% in a
effect on the reduction in risk attributed to breastfeeding population. This simple and
cesarean section and the prophylactic regimen. inexpensive regimen could decrease mother-to-child
Neonatal hematological abnormalities associated HIV-1 transmission in less-developed countries.
with antiretroviral intervention lasted for up to
seven weeks. Weight and length, although
significantly lower at birth, were normal by six to Holmes, W. and T. Kwarteng. 2001. “Parent to
eight weeks. CONCLUSION: A much reduced child transmission of HIV: policy considerations
three-arm regimen of zidovudine prophylaxis in in the Asia-Pacific region,” J. Clin. Virol.,
combination with cesarean section before labor is vol. 22, no. 3, pp. 315–324.
highly effective in reducing the risk of vertical HIV
Abstract: BACKGROUND: As HIV spreads
transmission and is safe for the infant.
through many countries in Asia and the Pacific,
women of reproductive age are becoming infected
274
and we can expect increasing numbers of infants to virus type one (HIV-1), we performed a meta-
be infected. Rapid advances in knowledge about analysis using data on individual patients from
mother-to-child transmission (MTCT), new 15 prospective cohort studies. METHODS: North
findings from intervention studies, recognition of American and European studies of at least
complex ethical implications, and changing 100 mother-child pairs were included in the meta-
attitudes and behaviors combine to create analysis. Uniform definitions of modes of delivery
uncertainty for policy makers. OBJECTIVE: Policy were used. Elective cesarean sections were defined
makers need sound advice but MTCT and its as those performed before onset of labor and
prevention are complicated topics. We aim to rupture of membranes. Multivariate logistic-
provide an overview of MTCT of HIV and suggest regression analysis was used to adjust for other
some key points to consider in the allocation of factors known to be associated with vertical
resources. STUDY DESIGN: This is a policy transmission. RESULTS: The primary analysis
analysis based on review of the literature, included data on 8,533 mother-child pairs. After
consultation with policy makers and researchers, adjustment for receipt of antiretroviral therapy,
and observations in the context of projects in maternal stage of disease, and infant birthweight,
developing countries. RESULTS: The risk of MTCT the likelihood of vertical transmission of HIV-1
is between 15% and 40%, but the use of was decreased by approximately 50% with elective
antiretroviral prophylaxis, elective cesarean section, cesarean section, as compared with other modes of
and replacement of breastfeeding can reduce this to delivery (adjusted odds ratio=0.43; 95% confidence
less than 4%. But most infected women in interval: 0.33 to 0.56). The results were similar
developing countries are unaware that they are when the study population was limited to those
HIV-infected and do not yet have access to these with rupture of membranes shortly before delivery.
‘test-dependent’ interventions (interventions based The likelihood of transmission was reduced by
on testing for HIV infection). Population-based approximately 87% with both elective cesarean
strategies that address known influences on the risk section and receipt of antiretroviral therapy during
of MTCT can be implemented with benefits for the the prenatal, intrapartum, and neonatal periods, as
health of both men and women. The test- compared with other modes of delivery and the
dependent interventions can have adverse effects as absence of therapy (adjusted odds ratio=0.13; 95%
well as benefits, careful preparation is necessary confidence interval: 0.09 to 0.19). Among mother-
before they are introduced in resource poor child pairs receiving antiretroviral therapy during
settings. The public health impact of test-dependent the prenatal, intrapartum, and neonatal periods,
interventions is limited by difficulties in achieving rates of vertical transmission were 2.0% among the
wide coverage and because they miss women who 196 mothers who underwent elective cesarean
become infected late in pregnancy or during section and 7.3% among the 1,255 mothers with
lactation who have the highest risk of MTCT. other modes of delivery. CONCLUSIONS: The
CONCLUSIONS: We argue for a broad response results of this meta-analysis suggest that elective
to the problems raised by MTCT of HIV that cesarean section reduces the risk of transmission of
Abstract: This article focuses on the effects of the care providers integrate interventions to limit
worldwide human immunodeficiency virus (HIV) mother-to-child transmission (MTCT) of HIV in a
epidemic on the lives of pregnant women and their manner consistent with existing information. There
infants in the developing world. It discusses the are two major reasons for this difference: access to
natural history of mother-to-child transmission prophylactic antiretroviral therapy (ARV) for HIV-
(MTCT) in HIV, including the role of breastfeeding infected pregnant mothers and availability of
and the effectiveness of various treatment/ alternative feeding for babies. In resource-poor
prevention schemes in resource-poor communities. settings, these options are beyond reach for the
Although the treatment schemes are not the same majority of the women. Infant and under-five
as those used in North America, the underlying mortality rates from other infections are high in
principles of transmission are the same. these settings and breastfeeding remains the norm.
Understanding the mechanisms of MTCT and Answering the question, What is an achievable
recognizing the benefits of even short-term standard of care in resource-poor settings? still
therapies can promote appropriate interventions remains a major challenge today. Dialogue has
when complete perinatal antiretroviral therapy is begun in most resource-poor settings to address the
impossible. key elements in the package of interventions to
reduce MTCT of HIV. These elements include the
following: (1) overall prevention of HIV in mothers
Limpongsanurak, S., P. Thaithumyanon, U. and fathers; (2) provision of good-quality
Thisyakorn, K. Ruxrungtham, S. voluntary testing and counseling (VCT) in
Chaithongwongwatthana, P. Kongsin, et al. antenatal clinics; (3) a comprehensive package of
2001. “Intrapartum zidovudine infusion alone interventions during pregnancy, during labor, and
failed to reduce both maternal HIV-1 viral load after delivery, including screening for sexually
and HIV-1 infection in infant,” J. Med. Assoc. transmitted diseases (STDs), family planning,
Thai., vol. 84, no. 5, pp. 611–616. and—where possible—ARVs; (4) provision of
Abstract: A pilot clinical trial to assess the efficacy infant and maternal nutrition within the
of intrapartum zidovudine (ZDV) infusion alone in socioeconomic realities; (5) advocacy and program
276
communication; and (6) other supportive measures, Mandelbrot, L., P. Msellati, N. Meda, V. Leroy, R.
including community mobilization to address issues Likikouet, P. P. van de, et al. 2002. “15 Month
such as stigmatization of and violence against HIV- follow up of African children following vaginal
infected women. This paper discusses the cleansing with benzalkonium chloride of their
challenges faced by most resource-poor settings in HIV infected mothers during late pregnancy
integrating some of these activities into and delivery,” Sex Transm. Infect., vol. 78,
reproductive care services. no. 4, pp. 267–270.
Abstract: OBJECTIVES: To study mother to child
Lutter, C. and W. Freire. 2000. Maternal HIV HIV-1 transmission (MTCT) and infant mortality
infection and breastfeeding in Honduras: following benzalkonium chloride (BC) disinfection.
analysis of the need for infant formula. METHODS: A Randomized, double blind phase II
placebo controlled trial. Women testing positive for
Abstract: As part of a continuing strategy to HIV-1 infection in prenatal care units in Abidjan,
prevent and contain the spread of HIV infection, Cote d’Ivoire, and Bobo-Dioulasso, Burkina Faso,
the Ministry of Honduras (MOHS) has been from November 1996 to April 1997 were eligible,
working to develop an integrated package of with their informed consent. Women self
interventions to reduce mother-to-child administered daily a vaginal suppository of 1% BC
transmission. This package includes the promotion (53) or matched placebo (54) from 36 weeks of
and availability of voluntary HIV testing and pregnancy, plus a single dose during labor. The
counseling (VCT) for all pregnant women, anti neonate was bathed with 1% BC solution or
retroviral therapy (ARV) during pregnancy, and the placebo within 30 minutes after birth. MTCT rate
provision of infant formula postpartum. This was assessed based on repeated polymerase chain
package will be field tested as a pilot project in the reaction (PCR) and serology results. For the present
cities of Tegucigalpa and San Pedro Sula beginning analysis, children were followed up to 15 months.
at the end of this year. RESULTS: A total of 107 women were enrolled. Of
103 eligible liveborn children, 23 were HIV
Luzuriaga, K. and J. L. Sullivan. 2002. “Pediatric infected, 75 uninfected, and five of indeterminate
HIV-1 infection: advances and remaining status. MTCT transmission rate was 24.2% overall
challenges,” AIDS Rev., vol. 4, no. 1, (95% confidence interval (CI): 14.3% to 30.4%).
pp. 21–26. On an intent to treat basis, the transmission rate
did not differ between the two groups (23.5%,
Abstract: HIV-1 infection is one of the leading 95% CI: 13.8% to 38.5%, in the BC group and
causes of childhood morbidity and mortality 24.8%, 95% CI: 15.0% to 39.6%, in the placebo
globally and mother-to-child transmission (MTCT) group at 15 months). Similarly, there was no
is the major mode of infection. Over the past difference in mortality at 15 months (22.9%,
decade, natural history and interventional studies 95% CI: 13.7% to 36.9%, in the BC group and
277
HIV-1 transmission, but little is known about the Abstract: mother-to-child transmission (MCT) of
morbidity risks associated with formula feeding in Human Immunodeficiency Virus (HIV) is the main
infants of HIV-1-infected women in resource-poor cause of the spread of the HIV epidemic in the
settings. OBJECTIVE: To compare morbidity, pediatric population. It is estimated that to date,
nutritional status, mortality adjusted for HIV-1 three million children worldwide have been
status, and cause of death among formula-fed and infected by HIV. The epidemic burden in
breastfed infants of HIV-1-infected women. developing countries is dramatic. Ninety-five
DESIGN: Randomized clinical trial conducted percent of the world’s HIV-infected women are
between 1992 and 1998. SETTING: Four antenatal living in developing countries. In industrialized
clinics in Nairobi, Kenya. PARTICIPANTS: Of countries, antiretroviral treatment of pregnant
401 live-born, singleton, or first-born twin infants women and newborns with azidothymidine (AZT,
of randomized HIV-1-seropositive mothers, 371 ACTG 076 regimen) and discouraging
were included in the analysis of morbidity and breastfeeding by HIV-infected mothers are
mortality. INTERVENTIONS: Mothers were effectively reducing MCT of HIV. However, there
randomly assigned either to use formula (n=186) or are three major obstacles to the systematic
to breastfeed (n=185) their infants. MAIN application of these strategies in developing
OUTCOME MEASURES: Mortality rates, adjusted countries: (a) difficulties in implementing the
for HIV-1 infection status; morbidity; and complex AZT administration and its corollary the
nutritional status during the first two years of life. avoidance of breastfeeding; (b) the complexity of
RESULTS: Two-year estimated mortality rates the logistics of the ACTG 076 regimen; (c) cost.
among infants were similar in the formula-feeding Indeed, in developing countries the socioeconomic
and breastfeeding arms (20.0% vs. 24.4%; hazard situation of the populations are precarious and
ratio [HR], 0.8; 95% confidence interval [CI]: health structures and services are underdeveloped.
0.5–1.3), even after adjusting for HIV-1 infection In addition, the anxiety and the reluctance of
status (HR, 1.1; 95% CI: 0.7–1.7). Infection with general population in the face of the HIV problem
HIV-1 was associated with a nine-fold increased and the high prevalence of maternal anemia reduce
mortality risk (95% CI: 5.3–15.3). The incidence the acceptability and safety of AZT treatment for
of diarrhea during the two years of follow-up was pregnant women in developing regions. Only
similar in formula and breastfeeding arms (155 vs. interventions that are applicable, acceptable, safe,
149 per 100 person-years, respectively). The affordable, of low cost and integrated into health
incidence of pneumonia was identical in the two system will be able to reduce HIV MCT. We now
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
groups (62 per 100 person-years), and there were know that MCT occurs mostly during the perinatal
no significant differences in incidence of other period and the maternal viral load in blood, in
recorded illnesses. Infants in the breastfeeding arm cervical secretions and in breastmilk appears to be
tended to have better nutritional status, the main determinant of transmission. Maternal
significantly so during the first six months of life. vitamin A deficiency may also favor MCT of HIV.
CONCLUSIONS: In this randomized clinical trial, It is however possible that this association is
infants assigned to be formula fed or breastfed had confounded by the relationship between advanced
similar mortality rates and incidence of diarrhea maternal HIV disease (a known risk factor for
and pneumonia during the first two years of life. transmission) and vitamin A deficiency. In spite of
However, HIV-1-free survival at two years was these uncertainties concerning determinants of
significantly higher in the formula arm. With MCT of HIV, several interventions have been
appropriate education and access to clean water, designed. The first involves treating the mother
formula feeding can be a safe alternative to with antiretroviral drugs for the perinatal period.
breastfeeding for infants of HIV-1-infected mothers The second is vaginal disinfection by application of
in a resource-poor setting. virucidal antiseptics during the perinatal period.
The third is to give vitamin A supplements to
pregnant women and children. Finally, passive
Meda, N., P. Msellati, C. Welffens-Ekra, M. immunotherapy with anti-HIV antibodies applied
Cartoux, V. Leroy, P. P. van de, and R. to pregnant women and/or new born, may be
Salamon. 1997. “The reduction of mother-child beneficial. The feasibility, safety and efficacy of
transmission of HIV infection in developing these potential interventions have not yet been
countries: potential intervention strategies, demonstrated in developing countries. In view of
obstacles to implementation and perspectives. the dramatic spread of HIV infection in these
The Reduction of Mother-Child Transmission countries, the evaluation of these interventions is of
of HIV Infection in Africa Group,” Santé, utmost priority. These trials are necessary because
vol. 7, no. 2, pp. 115–125. of the public health emergency but should be
278
performed in strict respect of human rights and 7.0%–11.6%) for Zdv/3TC (P=.11). Excluding
medical ethics. infections detected within 72 hours (intrauterine),
new HIV-1 infections were detected in
5.7% (95% CI: 3.7%–7.8%) and 3.6% (95% CI:
Mofenson, L. M. and J. A. McIntyre. 2000. 2.0%–5.3%) of infants in the Nvp and Zdv/3TC
“Advances and research directions in the groups, respectively, in the eight weeks after
prevention of mother-to-child HIV-1 birth. There were no drug-related maternal or
transmission,” Lancet, vol. 355, no. 9222, pediatric serious adverse events. Common
pp. 2237–2244. complications were obstetrical for mothers (Nvp
Abstract: Although substantial progress has been group, 24.3%; Zdv/3TC group, 26.3%) and
made in preventing mother-to-child HIV-1 respiratory for infants (Nvp group, 16.1%;
transmission in the past decade, critical research Zdv/3TC group, 17.0%). This study further
questions remain. Two perinatal epidemics now confirms the efficacy and safety of short-course
exist. In more-developed countries, integration of ARV regimens in reducing MTCT rates in
prenatal HIV-1 counseling and testing programs developing countries.
into an existing antenatal infrastructure,
availability of effective antiretroviral prophylaxis,
Moore, M. 2003. A behavior change perspective
and access to infant formula have resulted in new
on integrating PMTCT and Safe Motherhood
perinatal infections becoming rare. However,
programs, The Change Project.
identification of missed prevention opportunities,
the causes of prophylaxis failure, and the potential Abstract: In the context of an increase in AIDS-
effects of in-utero antiretroviral exposure have related maternal deaths and high prevalence of
become a priority. In less-developed countries, obstetric-related maternal mortality in most
antenatal care is limited, testing programs are African nations, this paper argues the needs for
almost non-existent, effective interventions remain programs that simultaneously address both
unimplemented, and prevention of postnatal problems.
transmission through breastmilk while maintaining It outlines barriers to the widespread
adequate infant nutrition is a major dilemma. The implementation of effective prevention of mother-
challenge for the next decade is to simultaneously to-child transmission (PMTCT) and Safe
address questions relevant to both epidemics while Motherhood (SM) programs and the ways in which
bridging the gap in prevention of perinatal behavior change interventions can break these
transmission between more-developed and less- down. The paper reviews research results and field
developed countries. experience from a behavior change perspective to
see what can be applied to develop and strengthen
the essential behavior change component of
Moodley, D., J. Moodley, H. Coovadia, G. Gray, J. PMTCT programs. It briefly discusses some of the
McIntyre, J. Hofmyer, et al. 2003. “A
transmission to the nursing baby. Various routes of 1-infected women were examined as part of a
infection and relative rates of transmission have perinatal HIV-1 project in Mombasa, Kenya.
been studied in many parts of the world, leading Polymerase chain reaction analysis was used to test
to the blanket guideline that babies of HIV- for HIV-1 in the infants at birth and at six weeks.
infected mothers should not be breastfed, if a safe The maternal HIV-1 seroprevalence was 13.3%
alternative can be provided. However, due to the (298 of 2,235). The overall rate of MTCT of HIV-
limits inherent in various studies and various one was 25.4%; polymerase chain reaction analysis
testing methods, the exact frequency of breastmilk revealed that of the 201 infants 6.0% (12) were
transmission of HIV during the course of lactation already HIV-1-positive at birth (intrauterine
remains unknown, and the conclusions drawn are transmission) and 19.4% (39) were infected during
thus conflicting and confusing. Replacement the peripartum period or in early neonatal life
feeding of young babies with non-human milks (perinatal transmission). The prevalence of acute
and other foods may be hazardous in poverty- chorioamnionitis was 8.8%, that of deciduitis was
stricken populations in Africa and elsewhere, and 10.8%, and that of villitis was 1.6%. Acute
still more research suggests that there are several chorioamnionitis was independently associated
properties in human milk that may provide with peripartum HIV-1 transmission but not with
specific protection to the baby of an infected in utero MTCT (17.9% vs. 6.7%, respectively;
mother. The possibility of providing the mother’s adjusted odds ratio, 3.9; 95% confidence interval:
own treated expressed breastmilk to the baby at 1.2–12.5; p=.025). Other correlates of perinatal
risk of HIV infection via breastfeeding is an MTCT were presence of HIV in the genital tract
alternative which has yet to be fully explored and and in the baby’s oral cavity and a high maternal
ways that this could be accomplished are viral load in peripheral blood. The adjusted
examined. Those of us working with mothers and population attributable fraction of 12.8%
babies need more information before we can assist (95% confidence interval: 1.5%–22.8%) indicated
mothers living with HIV to make truly informed that approximately 3% of MTCT could be
decisions about the safest way to feed their babies. prevented if acute chorioamnionitis was eliminated.
280
We suggest that further research on the role of mortality rates and HIV-1-free survival in breastfed
antimicrobial treatment in the prevention of and formula-fed infants. DESIGN AND SETTING:
chorioamnionitis and the reduction of peripartum Randomized clinical trial conducted from
MTCT needs to be performed. November 1992 to July 1998 in antenatal clinics in
Nairobi, Kenya, with a median follow-up period of
24 months. PARTICIPANTS: Of 425 HIV-1-
Nagelkerke, N. J., S. Moses, J. E. Embree, F. seropositive, antiretroviral-naive pregnant women
Jenniskens, and F. A. Plummer. 1995. “The enrolled, 401 mother-infant pairs were included in
duration of breastfeeding by HIV-1-infected the analysis of trial end points. INTERVENTIONS:
mothers in developing countries: balancing Mother-infant pairs were randomized to
benefits and risks,” J. Acquir. Immune. Defic. breastfeeding (n=212) vs. formula feeding arms
Syndr. Hum. Retrovirol., vol. 8, no. 2, (n=213). MAIN OUTCOME MEASURES: Infant
pp. 176–181. HIV-1 infection and death during the first two
Abstract: How best to advise mothers infected years of life, compared between the two
with human immunodeficiency virus type one intervention groups. RESULTS: Compliance with
(HIV-1) in developing countries regarding the assigned feeding modality was 96% in the
breastfeeding is an important issue that has breastfeeding arm and 70% in the formula arm
generated considerable debate. Previous studies (P<.001). Median duration of breastfeeding was 17
have addressed this problem by means of months. Of the 401 infants included in the
mathematical models, but without considering the analysis, 94% were followed up to HIV-1 infection
issue of the duration of breastfeeding. A or mortality end points: 83% for the HIV-1
mathematical model was developed to compare infection end point and 93% to the mortality end
the age-specific risks of mother-to-child HIV point. The cumulative probability of HIV-1
transmission versus the excess mortality due to not infection at 24 months was 36.7%
breastfeeding. In this model it is assumed that (95% confidence interval [CI]: 29.4%–44.0%) in
both the risk of mother-to-child transmission of the breastfeeding arm and 20.5% (95% CI:
HIV through breastmilk and the relative risk of 14.0%–27.0%) in the formula arm (P=.001). The
not breastfeeding do not vary with age. The model estimated rate of breastmilk transmission was
indicates that, in HIV-1-seropositive mothers, the 16.2% (95% CI: 6.5%–25.9%). Forty-four percent
decrease in child mortality afforded by of HIV-1 infection in the breastfeeding arm was
breastfeeding may exceed the risk of mother-to- attributable to breastmilk. Most breastmilk
child HIV-1 transmission only during the first transmission occurred early, with 75% of the risk
three to seven months of life. Thereafter the risk of difference between the two arms occurring by six
HIV-1 transmission probably exceeds the mortality months, although transmission continued
benefit of breastfeeding. Experimental studies of throughout the duration of exposure. The two-year
counseling HIV-1-infected mothers to limit their mortality rates in both arms were similar
(breastfeeding arm, 24.4% [95% CI:
281
Abstract: In June 2001 the United Nations Special preventing MTCT of HIV-1 by breastfeeding.
Assembly on HIV/AIDS set reduction targets of Preventive strategies supported by WHO/UNICEF
20% and 50% for the numbers of children newly and charitable agencies in some sentinel centers in
infected with HIV by 2005 and 2010 respectively. sub-Saharan Africa include routine antenatal
Are these targets achievable? Antiretroviral voluntary counseling and testing (VCT), PCR
monotherapy during pregnancy, delivery, and the testing of infants of seropositive mothers at six
neonatal period can reduce the rate of mother-to- weeks of age, various combinations of a shortened
child transmission of HIV-1 by two-thirds in non- period (three to six months) of exclusive
breastfeeding populations. Shorter and simpler breastfeeding, perinatal administration of
regimens of monotherapy have been associated antiretrovirals (ARV) such as nevirapine and
with a reduction of 50% in such transmission provision of affordable and safe infant replacement
among non-breastfeeding populations and of up to feeds (presently given free by UNICEF in some
40% in breastfeeding populations. Delivery by centers). Many problems, however, have hindered
elective cesarean section is associated with a effective implementation of these interventions. In
halving of the risk of mother-to-child transmission. many poor communities, even where VCT facilities
However, breastfeeding poses a substantial are available, acceptance of HIV testing is low
additional risk of acquisition of HIV, and if because there is fear of stigmatization by the
prolonged it more than doubles the overall rate of spouse, family or community and compliance with
transmission. Rates below 2% are being reported complex drug regimens is therefore poor. Other
from settings where combination therapy is applied problems include the exorbitant cost of
during pregnancy and delivery, delivery is by antiretroviral drugs, inadequately resourced health
elective cesarean section, and breastfeeding does care systems and unavailability or poor acceptance
not take place. In breastfeeding populations where of safe breastmilk alternatives. The rate of mixed
elective cesarean delivery is not an option but feeding is high and so the risk of MTCT is
peripartum antiretroviral therapy is used, rates at increased. Continued promotion of exclusive
six weeks are about 10% but can be 25% or more breastfeeding for at least six months, irrespective of
after 18 months of breastfeeding. More widely HIV status, followed by a properly prepared, high
applicable interventions are being developed, such energy, nutritious complementary diet, with the
as cleansing of the birth canal and antiretroviral possibility of early weaning to an animal milk
therapy during the breastfeeding period. formula, still appears to be the most appropriate
option for the poor in countries with high levels of
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
Available at:
MTCT not deriving any benefit from the above
http://www.who.int/bulletin/pdf/2001/issue12/79(1
strategies. While a longer period of breastfeeding
2)1138–1144.pdf
would probably increase the risk of MTCT in
vulnerable communities, a shorter duration would
Ogundele, M. O. and J. B. Coulter. 2003. “HIV certainly increase infant morbidity and mortality.
transmission through breastfeeding: problems Results of investigations of the efficacy of ARV for
and prevention,” Ann. Trop. Paediatr., vol. 23, protecting the infants of HIV-infected mothers
no. 2, pp. 91–106. during the breastfeeding period are awaited.
282
advice during pre- and post-test HIV counseling Population Council/ICRW. 2001. Community
were assessed and compared with those of involvement in initiatives to prevent mother-to-
uninfected mothers. METHODS: Mothers of child transmission of HIV: insights and
infants aged 2–12 months, 55 HIV-infected and 85 recommendations.
HIV-uninfected, were recruited from the HIV
Abstract: By supporting community involvement,
Family Support Unit in Lusaka, Zambia. HIV
we can enhance prevention of mother-to-child
status was known to 121 of these mothers, who
transmission of HIV. Our recommendations are for
had all received pre- and post-test HIV counseling.
the benefit of program managers, policymakers,
Feeding practices were determined by verbal
and donors and apply to preventing vertical
questionnaire. RESULTS: All mothers breastfed but
transmission of HIV in a number of settings,
only 35% of infants below four months were
including prevention services for women who are
exclusively breastfed (received breastmilk only).
likely to become pregnant and their partners. The
HIV-infected mothers introduced fluids and weaned
recommendations acknowledge the right of people
their infants significantly earlier than HIV-
to know their serostatus and to access the
uninfected mothers (p=0.03 and p=0.002,
information, services, and support they need to
respectively). Infants of HIV-infected mothers had
make decisions based on this knowledge. We hope
significantly lower weight for age Z (WAZ) scores
that our recommendations will encourage program
indicating poorer nutritional or health status
planners to include community participation,
(p=0.004). Commercial formula milk and cow’s
education, and mobilization as critical program
milk were used by 36 mothers as breastmilk
elements.
substitutes, and were introduced at a median age of
2.5 months. Thirteen mothers gave cow’s milk, and Available at:
no mother added water to cow’s milk (as http://www.popcouncil.org/pubasps/PublicationDet
recommended), with two adding sugar and four ails.asp?PublicationID=1677
adding salt. CONCLUSION: Infant-feeding
practices of HIV-infected mothers differed
significantly from HIV-uninfected mothers, and this Preble, E. A. and E. G. Piwoz. 2002. Prevention of
may contribute to their poorer growth. mother-to-child transmission of HIV in Africa:
Paradoxically these mothers feeding practice could practical guidance for programs.
be putting these infants at greater risk of both non- Abstract: Prevention of mother-to-child
HIV-related morbidity and HIV transmission, as transmission (MTCT) of human immunodeficiency
early introduction of foods other than breastmilk virus (HIV), also known as vertical, perinatal, or
may increase MTCT. parent-to-child transmission, has become an
important priority for many developing country
Piwoz, E., S. Huffman, D. Lusk, E. Zehner, and C. governments and agencies in Africa. It is consistent
O’Gara. 2000. Early breastfeeding cessation as not only wit the broader goals of HIV/AIDS
284
designed randomized controlled trials to estimate Skordis, J. and N. Nattrass. 2002. “Paying to
the effects of vaginal disinfection on MTCT of waste lives: the affordability of reducing
HIV. mother-to-child transmission of HIV in South
Africa,” J. Health Econ., vol. 21, no. 3,
pp. 405–421.
Sirinavin, S. S., W. Phaupradit, S. Taneepanichskul,
K. Atamasirikul, P. Hetrakul, A. Thakkinstian, Abstract: It is estimated that each HIV-positive
and P. Panburana. 2000. “Effect of immediate child in South Africa costs the government more in
neonatal zidovudine on prevention of vertical terms of health and welfare expenses than it does
transmission of human immunodeficiency virus to reduce mother-to-child transmission (MTCT) of
type 1,” Int. J. Infect. Dis., vol. 4, no. 3, HIV through the use of antiretroviral regimens
pp. 148–152. (where the mother continues to breastfeed).
programs to reduce MTCT of HIV/AIDS are, thus,
Abstract: OBJECTIVE: To describe the effects of clearly affordable. Using Nevirapine (according to
various short zidovudine (ZDV) prophylactic the HIVNET 012 Protocol) saves fewer lives, but is
regimens on vertical transmission of human more cost-effective than using Zidovudine (CDC
immunodeficiency virus type 1 (HIV-I) infection, two weeks regime).
especially the effect of immediate neonatal ZDV
prophylaxis. MATERIALS AND METHODS: The
study included children of HIV-1-infected mothers Smith, M. M. and L. Kuhn. 2000. “Exclusive
who were born at a teaching hospital in Bangkok. breast-feeding: does it have the potential to
The ZDV prophylaxis regimens varied by time reduce breast-feeding transmission of HIV-1?”
periods that included: (1) no ZDV (1991–1996); Nutr. Rev., vol. 58, no. 11, pp. 333–340.
(2) antenatal oral ZDV, 250mg given twice a day
Abstract: Exclusive breastfeeding is
starting at 34 to 36 weeks’ gestation and
unambiguously the optimal infant feeding practice
continued until labor (1995–1998); (3) antenatal
and is universally promoted in the absence of
oral ZDV plus immediate neonatal oral ZDV,
human immunodeficiency virus (HIV-1). It is
6mg/0.6 mL/dose started within the first two
associated with reduced morbidity and mortality
hours after birth and continued at six-hour
from diarrheal and respiratory diseases. Recent
intervals for four to six weeks (1997–1998); and
findings suggest that exclusive breastfeeding may
(4) intrapartum intravenous ZDV given in
pose less risk of HIV-1 transmission than the
addition to regimen 3 (1998–1999). Neonatal
more common practice of mixed feeding (i.e.,
ZDV was administered within two hours after
breastfeeding concurrent with the feeding of
birth in 95% of the neonates. RESULTS: In a
water, other fluids, and foods), which has
cohort of 136 children born at least nine months
important infant feeding policy implications for
before the analysis date, the HIV-1 vertical
low-resource settings. This paper reviews the
infection rates were: (1) no ZDV, 11 of 48
biologic mechanisms associated with exclusive
285
Soderlund, N., K. Zwi, A. Kinghorn, and G. Gray. prenatal care. RESULTS: For women in prenatal
1999. “Prevention of vertical transmission of care, mass provision of NVP without maternal
HIV: analysis of cost effectiveness of options serodiagnosis was found to yield greater health
available in South Africa,” BMJ, vol. 318, gains at an acceptable cost, compared with
no. 7199, pp. 1650–1656. providing targeted therapy to only those women
identified as seropositive. However, this conclusion
Abstract: OBJECTIVE: To assess the cost
was strongly contingent on several uncertain
effectiveness of vertical transmission prevention
assumptions, most importantly the probability that
strategies by using a mathematical simulation
a woman who does not know her serostatus will
model. DESIGN: A Markov chain model was used
nonetheless adhere to therapy. Among those
to simulate the cost effectiveness of four formula
women who present for delivery without prior
feeding strategies, three antiretroviral
enrollment in a prenatal strategy, either late
interventions, and combined formula feeding and
provision of maternal-infant NVP or treatment of
antiretroviral interventions on a cohort of 20,000
only the infant would likely be a cost-effective
pregnancies. All children born to HIV positive
alternative to the current practice of offering no
mothers were followed up until age of likely death
preventive therapy. CONCLUSIONS: NVP
given current life expectancy and a cost per life
intervention offers a cost-effective avenue for
year gained calculated for each strategy.
preventing vertical HIV transmission in sub-
SETTING: Model of working class, urban South
Saharan Africa. The optimal choice between mass
African population. RESULTS: Low cost
therapy and targeted therapy cannot be confidently
antiretroviral regimens were almost as effective as
identified without information regarding adherence
high cost ones and more cost effective when
among women who do not know their serostatus.
formula feeding interventions were added. With or
For women who do not receive NVP prenatally,
without formula feeding, low cost antiretroviral
treatment on presentation for delivery would be
interventions were likely to save lives and money.
cost-effective even in the face of modest clinical
Interventions that allowed breastfeeding early on,
efficacy. Clinical assessment of adherence to
to be replaced by formula feeding at four or seven
therapy among women who do not know their
months, seemed likely to save fewer lives and
status and the field effectiveness of alternative
offered poorer value for money. CONCLUSIONS:
approaches to NVP administration is urgently
Antiretroviral interventions are probably cost
needed to allow identification of optimal
effective across a wide range of settings, with or
prevention strategies.
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
286
USAID Missions on how to approach MTCT; Tess, B. H., L. C. Rodrigues, M. L. Newell, D. T.
MTCT research and service delivery support at Dunn, and T. D. Lago. 1998. “Infant feeding
antenatal care hospitals, such as the Chris Hani and risk of mother-to-child transmission of
Baragwanath Hospital in South Africa; MTCT HIV-1 in Sao Paulo State, Brazil. Sao Paulo
information sharing among donors and developing Collaborative Study for Vertical Transmission
country partners; and much more. of HIV-1,” J. Acquir. Immune. Defic. Syndr.
As the HIV/AIDS epidemic continued to Hum. Retrovirol., vol. 19, no. 2, pp. 189–194.
escalate, increased USAID investments in
Abstract: Although vertical transmission of HIV-1
prevention of MTCT will be critical in saving the
can occur through breastfeeding, little is known
lives of children made vulnerable to HIV/AIDS
about the effect of colostrum, duration of
around the world.
breastfeeding, mixing feeding, and nipple
Available at: pathology. We used retrospective cohort data to
http://www.synergyaids.com/Documents/projectpro examine the association between breastfeeding-
files_2002.pdf related factors and transmission of HIV-1 from
mother to child in Sao Paulo State, Brazil.
Information on maternal and postnatal factors was
Taha, T. E. and R. H. Gray. 2000. “Genital tract collected by medical record review and interview.
infections and perinatal transmission of HIV,” Infection status was determined for 434 children by
Ann. N.Y. Acad. Sci., vol. 918, pp. 84–98. anti-HIV-1 tests performed beyond 18 months of
Abstract: In areas of the world where genital tract age or diagnosis of AIDS at any age. Among
infections (GTIs) are common, the prevalence of 168 breastfed children, the risk of transmission of
HIV and the rate of mother-to-child transmission HIV-1 was 21%, compared with 13% (p=.01)
(MTCT) of HIV are also high. Although among 264 children artificially fed. Breastfeeding
observational studies suggested that GTIs are was independently and significantly associated with
associated with MTCT of HIV, no controlled mother-to-child transmission of HIV-1 after
clinical trial has confirmed this finding. It is likely controlling for stage of maternal HIV-1 disease
that GTIs that cause either discharges or ulcers (odds ratio [OR]=2.2; 95% confidence interval
during pregnancy increase perinatal transmission of [CI]: 1.3–3.8). A trend was shown toward an
HIV. Several potential biological mechanisms might increased risk of transmission with longer duration
facilitate perinatal transmission. For example, of breastfeeding, a history of bleeding nipples, and
chorioamnionitis, increased viral shedding in introduction of other liquid food before weaning,
cervicovaginal secretions, increased HIV but these associations were not statistically
acquisition during pregnancy, inflammatory significant. History of colostrum intake or cracked
cytokine production, preterm labor, prolonged nipples without bleeding were not associated with
rupture of membranes, ascending infection, and transmission. Most of the women who breastfed
increased intrapartum infectious secretions are were unaware of their HIV-1 infection status at the
287
the vertical transmission rate was 15%–20%. account its HIV/AIDS epidemiology, its
High maternal load is the major risk factor for infrastructure and the available resources.
both intra-uterine and intra-partum mother-to- Providing services in a stepwise manner can aid in
child transmission. Prematurity is the most the achievement of PMTCT.
common adverse neonatal outcome associated
Available at:
with maternal HIV infection. Earlier diagnosis of
http://www.unaids.org/publications/documents/mtct
pediatric HIV infection than previously available is
/Technical%20Update%20No2.pdf
now possible with virological tests, particularly
HIV DNA polymerase chain reaction. An
estimated one fifth of infected children will have UNAIDS. 2002. Local monitoring and evaluation
been diagnosed with AIDS or have died by of the integrated prevention of mother-to-child
12 months of age, rising to a third by six years of HIV transmission in low-income countries.
age. Surgical and therapeutic interventions are
effective in reducing vertical transmission risk, in Abstract: Full text available at:
addition to the avoidance of breastfeeding. http://www.unaids.org/publications/documents/mtct
Cesarean section delivery before labor and before /index.html
rupture of membranes approximately halves the
risk of transmission, while prophylactic zidovudine UNAIDS. 2002. Nevirapine donation for
therapy according to the ACTG076 regimen prevention of mother-to-child transmission of
reduces transmission by up to two-thirds, HIV.
transmission is reduced even further with both
interventions. Trials of short-course zidovudine Abstract: Full text available at:
regimens show their effectiveness in reducing http://www.unaids.org/publications/documents/mtct
vertical transmission, in breastfeeding and non- /index.html
breastfeeding populations. Nevirapine has been
shown to be significantly more effective than short
UNAIDS. 2002. New data on the prevention of
course zidovudine regimens in breastfeeding
mother-to-child transmission of HIV and their
populations, but is still under evaluation in non-
policy implications.
breastfeeding populations additionally receiving
routine anti-retroviral prophylaxis. Reports of a Abstract: Full text available at:
small number of serious adverse events in
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
http://www.unaids.org/publications/documents/mtct
uninfected children exposed in utero or neonatally /index.html
to antiretroviral therapy need further investigation.
Trials of vitamin A supplementation to reduce
vertical transmission have had negative results, UNAIDS. 2002, PMTCT Intelligence Report.
while the effectiveness of vaginal lavage and Volume 1, Issue 4-5.
passive immune therapy in reducing vertical Abstract: Full text available at:
transmission remains uncertain. http://www.unaids.org/publications/documents/mtct
/index.html
UN Regional Task Force on Prevention of Mother-
to-Child Transmission of HIV. 2003. Prevention UNAIDS. 2002. Prevention of mother-to-child
of mother-to-child transmission of HIV: issues transmission of HIV: selection and use of
for South East Asia. Nevirapine (technical notes).
Abstract: There are at least six million people Abstract: Full text available at:
living with HIV/AIDS in the Asia Pacific region. http://www.unaids.org/publications/documents/mtct
The numbers of HIV-infected women and children /index.html
are increasing at an alarming rate. Important
components that need to be addressed in order to
successfully prevent and reduce perinatal HIV UNAIDS. 2002. Summary of new
transmission include VCCT, family planning, recommendations on the use of ARV in
obstetric care, ARV use and infant feeding. There preventing MTCT of HIV.
are many services that can aid in the PMTCT of
Abstract: Full text available at:
HIV and the care of HIV-infected mothers and
http://www.unaids.org/publications/documents/mtct
their children. Each country needs to take into
/index.html
288
UNAIDS. 2002. UNAIDS technical update mother- Abstract: BACKGROUND: Antiviral prophylaxis
to-child transmission of HIV. is recommended for HIV positive mothers to
prevent mother-to-child transmission of HIV. To
Abstract: Includes document and slides. Full text
date UNAIDS and WHO policy has been based on
available at:
a study in Thailand which showed a reduction in
http://www.unaids.org/publications/documents/mtct
transmission by half with short course AZT
/index.html
(Zidovudine) treatment together with artificial
feeding. We modeled the possible positive and
UNAIDS and UNICEF. 1999. Large-scale negative effects on child deaths in low and middle
implementation for the prevention of mother- resource developing country settings of two
to-child transmission of HIV: issues for South interventions to reduce mother-to-child
East Asia and the Pacific, UNAIDS Asia Pacific transmission (MTCT) of HIV: antenatal testing,
Intercountry Team Bangkok, UNICEF East short-course antivirals (zidovudine or nevirapine),
Asia Pacific Regional Office, WHO Thailand. firstly with and then without artificial feeding.
MATERIAL AND METHODS: Estimates are made
Abstract: Full text available at: of child lives likely to be saved by the program by
http://www.unaids.org/publications/documents/ age ten years, balanced against increases in deaths
mtct/updates1.1.doc due to more uninfected mothers choosing to use
artificial feeds where these are part of the
UNFPA/UNICEF/WHO/UNAIDS. 2000. “New intervention. Mid-point values for variables
Data on the Prevention of Mother-to-Child affecting the balance of mortality gains and losses
Transmission of HIV and their Policy are taken from recent published data for low and
Implications: Conclusions and middle income developing countries and a
recommendations,” WHO Weekly sensitivity analysis is undertaken. RESULTS: In low
Epidemiological Record. income settings the use of antivirals alone would
result in an estimated gain in child survival of
Abstract: On behalf of the Inter-Agency Task Team around 0.36%, representing 360 deaths avoided
on MTCT, WHO’s Department of Reproductive from a birth cohort of 100,000 by age ten years.
Health and Research, in collaboration with the Adding artificial feeding could reduce the gain to
HIV/STI Initiative and the Department of Child 0.03% (30 deaths avoided). In middle income
and Adolescent Health, convened a Technical settings the gain from antivirals alone would be
Consultation on new data on the prevention of 0.26% but as “spill-over” of artificial feeding to
MTCT and their policy implications. The objective uninfected women was more likely it could result
was to review recent scientific data and update in a net increase of child deaths of up to 1.08%
current recommendations on the provision of ARVs (1,080 additional deaths). A sensitivity analysis
and infant feeding counseling. The Technical emphasized this potential for regimens using
Consultation focused on these two components, artificial feeding if progam participation was low,
can be safely prepared is ensured (as is possible in results may help shape policy decisions about
industrialized countries), HIV-infected women feeding choices in the face of the HIV epidemic. Of
should be counseled not to breastfeed their infants. particular relevance is the need to account for
declining levels of protection with age in infancy,
the continued protection afforded during the
WHO Collaborative Study Team. 2000. “Effect of second year of life, and the question of the safety
breastfeeding on infant and child mortality due of breastmilk substitutes in families of low
to infectious diseases in less developed socioeconomic status.
countries: a pooled analysis. WHO
Collaborative Study Team on the Role of
Breastfeeding on the Prevention of Infant WHO and UNAIDS. 2002. WHO and UNAIDS
Mortality,” Lancet, vol. 355, no. 9202, continue to support use of nevirapine for
pp. 451–455. prevention of mother-to-child HIV
transmission.
Abstract: BACKGROUND: The debate on
breastfeeding in areas of high HIV prevalence has Abstract: The statement released 22 March 2002
led to the development of simulation models that by the United States National Institutes of Health
attempt to assess the risks and benefits associated (NIH), concerning some reporting and
with breastfeeding. An essential element of these documentation irregularities in clinical trial
simulations is the extent to which breastfeeding HIVNET012, does not warrant any change in the
protects against infant and child mortality; recommendations issued following a WHO
however, few studies are available on this topic. We technical consultation on mother-to-child HIV
did a pooled analysis of studies that assessed the transmission in October 2000.
effect of not breastfeeding on the risk of death due This expert group, convened by WHO on
to infectious diseases. METHODS: Studies were behalf of UNICEF, UNFPA, and the UNAIDS
identified through consultations with experts in Secretariat, concluded that the safety and
290
effectiveness of antiretroviral regimens, including population. The cost per DALY gained compares
nevirapine, in preventing mother-to-child HIV well with established public health and clinical
transmission has been clearly documented and that interventions in middle-income countries, even
the use of these regimens is thus warranted for without factoring in the care costs that would be
preventing mother-to-child HIV transmission. The saved through a successful program. Cost
simplest regimen requires a single dose of effectiveness is greatest where HIV prevalence is
nevirapine to the mother at delivery and a single highest.
dose to the newborn within 72 hours of birth.
Available at: World Health Organization. 2002. Breastfeeding
http://www.who.int/reproductive- and replacement feeding practices in the
health/rtis/MTCT/documents/WHO-UNAIDS- context of mother-to-child transmission of
NVP-statement-march-02.htm HIV—an assessment tool for research.
Abstract: This tool provides guidance for
Wilkinson, D., K. Floyd, and C. F. Gilks. 2000. researchers who seek to establish the nature of the
“National and provincial estimated costs and association and levels of risk of transmission
cost effectiveness of a program to reduce between patterns of infant feeding and mother-to-
mother-to-child HIV transmission in South child transmission of HIV (MTCT). Such a tool
Africa,” S. Afr. Med. J, vol. 90, no. 8, has not yet been developed for MTCT although
pp. 794–798. comparable tools have been used in other contexts,
such as childhood diarrhea. Many indicators,
Abstract: OBJECTIVE: To estimate the cost and cost
including those in Demographic and Health
effectiveness nationally and for each province of a
Studies, already exist. By drawing on these existing
program to reduce mother-to-child transmission
instruments and involving many investigators in
(MTCT) of HIV in South Africa. METHODS: A
the design of this tool, it is hoped that the data
model developed to estimate cost and cost
may be more consistently collected from study to
effectiveness of interventions in Hlabisa, KwaZulu-
study, allowing improved comparison across sites
Natal, was modified and applied to each province.
and meta/joint analyses of data sets.
This model predicts a 37% reduction in pediatric
This tool is designed to assess infant feeding
HIV infections if short-course oral zidovudine
patterns and their relation with MTCT. It is not
(ZDV) plus infant formula feed for four months is
intended to collect information on nutritional
provided within a strengthened health system.
adequacy of infant feeding.
Estimates of the number of pregnancies and HIV
prevalence among pregnant women per province in Available at:
1997 were combined with an estimated 30% MTCT http://www.who.int/reproductive-
rate. Costs were calculated from a health system health/publications/RHR_01_12/RHR_01_12.en.ab
perspective, and effectiveness was estimated as cost stract.html
291
Available at: World Health Organization. 1998. HIV and infant
http://www.who.int/bulletin/pdf/2002/bul-7-E- feeding.
2002/80(7)605.pdf
Abstract:
■ Guidelines for Decision Makers
World Health Organization. 2001. New data on ■ A Guide for Health Care Managers and
the prevention of mother-to-child transmission Supervisors
of HIV and their policy implications: ■ A Review of HIV Transmission Through
conclusions and recommendations. Breastfeeding
Abstract: Mother-to-child transmission (MTCT) of This set of three manuals offers the latest
HIV is the most significant source of HIV infection expert advice, from WHO, UNICEF, and UNAIDS,
in children below the age of ten years. The strategy on recommended safe practices for infant feeding
recommended by the United Nations agencies to when the mother is infected with HIV. Citing firm
prevent mother-to-child transmission of HIV evidence that HIV can be transmitted through
includes: (1) the primary prevention of HIV breastmilk, the manuals respond to the urgent need
infection among parents to be, (2) the prevention for guidance when advising infected mothers as
of unwanted pregnancies in HIV-infected women, well as formulating sound public health policies.
and (3) the prevention of HIV transmission from With this need in mind, the manuals identify the
HIV-infected women to their infants. While the wide range of precautions and policy options
best ways to prevent HIV infection in infants needed to reduce the risk of HIV transmission
remain primary prevention of HIV infection and through breastmilk while ensuring that the
reduction of unwanted pregnancies among women nutritional requirements of infants born to HIV-
who are infected with HIV, many HIV-infected infected mothers are adequately met.
women become pregnant. In 1994 a long and Although recommendations and advice have
complex regimen of the antiretroviral drug universal relevance, particular attention is given to
Zidovudine (ZDV) taken five times daily from the options for infant feeding in resource-poor settings
14th week of pregnancy and intravenously during where infectious diseases and malnutrition are the
labor was shown to reduce the risk of transmission leading causes of infant mortality and where
from mother to child by two-thirds, from 26% to artificial feeding may be hazardous as well as
8%. This regimen had little practical value in prohibitively expensive. The manuals also offer
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
developing countries and more appropriate short abundant advice on ways of ensuring that
course ZDV regimens starting later in pregnancy breastmilk substitutes reach only those infants who
were evaluated and also shown to be effective. are at risk of HIV infection and thus do not
Other interventions shown to prevent transmission undermine the unique advantages of breastfeeding
of HIV include elective cesarean section and the for the majority of women and infants. Other key
avoidance of breastfeeding. While these messages include the vital importance of
interventions have become standard practice in confidential counseling, the right of every mother
developed countries, they are not always practical to decide how she wishes to feed her child, and the
or safe in resource-limited settings. need to protect infected mothers from
stigmatization and discrimination.
Available at:
http://www.who.int/reproductive- 1998, available as a set of three manuals
health/rtis/MTCT/mtct_consultation_october_2000/ Order no. 1930135 (WHO)
consultation_documents/new_data_on_mtct_
Available at:
conclusions/table_of_contents_en.html
http://www.who.int/dsa/cat98/aids8.htm#HIV and
Infant Feeding
292
Newborn Immunization
Ballesteros-Trujillo, A., A. Vargas-Origel, T. have failed; (ii) the vaccination strategy must
Alvarez-Munoz, and C. Aldana-Valenzuela. incorporate a way of priming the immune system
2001. “Response to hepatitis B vaccine in to guarantee in all individuals this protective
preterm infants: four-dose schedule,” Am. J. response, normally generated in healthy contacts,
Perinatol., vol. 18, no. 7, pp. 379–385. upon natural infection by M. tuberculosis; (iii) the
strategy must incorporate a mechanism for
Abstract: The objective of this study is to test a
ensuring that the effectiveness of this priming is not
four-dose Hepatitis B vaccine schedule in
abrogated by exposure to environmental
premature infants (PI) and assess the
mycobacteria; and (iv) the strategy must take
immunogenicity of the vaccine with this schedule.
account of the fact that the vaccinated population
We studied 29 PI who received the vaccine against
is genetically heterogeneous, and that individuals
Hepatitis B at birth, one, five, and nine months of
will therefore respond variably to most standard
age. Antibodies against surface antigen (Anti-HBs)
vaccination protocols. We describe a tentative
were measured before the third and fourth doses
proposal for how these interrelated problems might
and 12 weeks after the fourth dose. Levels higher
be solved and discuss predictions of this tentative
than 10 mIU/mL were considered protective,
vaccination strategy. Critical testing of the
whereas more than 100 mIU/mL was an excellent
neonatal, low-dose BCG vaccination strategy can
response. Twenty-nine PI were studied. The average
only be achieved by a field trial and we outline the
weight at the time of the initial dose was 1,398g,
considerations underlying this proposal.
gestational age of 32.5 weeks, and a postnatal age
of nine days. Since the initial measurement,
protective levels were achieved in all patients. The Chauvin, P., D. Ekra, and S. Plotkin. 2002. The
response was excellent in 24.1%, 75.9%, and cost of not implementing routine neonates
89.7%, after the second, third, and fourth doses, immunization programs in HBsAg high
respectively. No correlation was found between the prevalence countries. 20 (2002).
type of response and the infants’ weight or the
postnatal age. The Anti-HBs geometrical levels Abstract: According to our data, delaying the first
were 51.9, 133, and 133 mIU/mL after the second, dose of HBV vaccine for weeks after a birth carries
third, and fourth doses, respectively. The favorable a “cost”: a non-negligible proportion of chronic
results obtained might be due to: the four-dose carriers among every birth cohort. A policy that
schedule itself, the dose we used (10 microg), the starts vaccination later than birth is incompatible
time interval between the doses, and even a race with the goal of reducing the incidence of chronic
factor. Our schedule seems to be useful for PI liver complications. This is true in sub-Saharan
infants and probably is no longer necessary to Africa, as well as Asia. At a time when access to
delay the vaccination, although this should be treatments and vaccines in developing countries
confirmed by further studies. constitutes a priority for health and development
policies, HBV vaccine strategies must be
implemented respecting the recommendation that
Bretscher, P., J. Menon, C. Power, J. Uzonna, and universal immunization must be started at birth.
G. Wei. 2001. “A case for a neonatal, low-dose
BCG vaccination trial,” Scand. J. Infect. Dis.,
Clark, S. J., M. D. Cabana, T. Malik, H. Yusuf,
NEWBORN IMMUNIZATION
293
the birth dose was recommended when a to children. Of the 270 pediatricians who
thimerosal-free vaccine became available. vaccinated children with hepatitis B vaccine and
OBJECTIVE: To explore changes in hepatitis B indicated their practice regarding the birth dose,
vaccination practices for newborns related to the 50% offered the first dose of hepatitis B vaccine at
revised recommendations for low-risk infants (in birth to all infants; the rest either offered the
this study, the terms newborn and infant are used vaccine at birth only to infants of hepatitis B
interchangeably). DESIGN: A telephone survey of a surface antigen-positive mothers and mothers
random sample of 1,000 U.S. hospitals. whose serostatus is unknown, or did not offer the
PARTICIPANTS: Nurse managers, nursery birth dose to any infants at all. Practicing in the
directors, and staff nurses of the newborn inner city, working for a medical school or
nurseries. MAIN OUTCOME MEASURES: government hospital, and living in a state with
Nursery vaccination practices before and after July universal immunization supply policies were
7, 1999, and the availability and use of thimerosal- associated with the respondent giving the birth
free vaccine. RESULTS: Interviews were conducted dose. The strongest perceived barriers to giving the
with 773 (87%) of 886 eligible hospitals. Before birth dose in the hospital were the difficulty
July 7, 1999, 78% of the hospitals reported tracking these vaccines (39%), the increased cost
vaccination practices that were consistent with (27%), and the lack of reimbursement from
recommendations at that time, although only insurance companies (26%). If a combination
47% vaccinated all low-risk infants at birth. After vaccine that includes hepatitis B; diphtheria,
July 7, 1999, almost all hospitals discontinued tetanus, pertussis (diphtheria and tetanus toxoids
vaccination of low-risk infants, in accordance with and acellular pertussis vaccine); and polio
the recommendation change; however, there was a (inactivated poliovirus vaccine) antigens become
six-fold increase in the number of hospitals that available in the near future, then 38% of
were not vaccinating all high-risk infants. After the physicians who currently give the birth dose to all
introduction of thimerosal-free vaccine, only infants would prefer to wait until two months of
39% of the hospitals reported vaccinating all low- age to initiate hepatitis B immunization.
risk infants. CONCLUSIONS: Most hospital CONCLUSIONS: Efforts to achieve high
nurseries altered their newborn hepatitis B implementation of hepatitis B birth dose
vaccination practices consistent with changes in administration may falter once a hepatitis B-
national recommendations. However, unintended containing pentavalent combination vaccine
consequences included the failure of some hospitals becomes available. Programmatic efforts should
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
to continue vaccinating all high-risk infants and the ensure prevention of perinatal hepatitis B virus
delay in reintroducing vaccination for low-risk transmission through universal prenatal hepatitis B
newborns after the introduction of a thimerosal- surface antigen screening and immunoprophylaxis
free vaccine. Assessments of the appropriateness of of high-risk newborn infants.
this country’s response to the threat of thimerosal
in vaccines should consider these findings.
Gong, J., R. C. Li, J. Y. Yang, Y. P. Li, X. R. Chen,
Z. Y. Xu, C. B. Liu, H. L. Cao, K. Zhao, and
Cooper, A., H. Yusuf, L. Rodewald, T. Malik, R. D. M. Ni. 2003. “Long-term efficacy of infant
Pollard, and L. Pickering. 2001. “Attitudes, hepatitis B immunization program,” Zhonghua
practices, and preferences of pediatricians Gan Zang. Bing. Za Zhi., vol. 11, no. 4,
regarding initiation of hepatitis B immunization pp. 203–205.
at birth,” Pediatr., vol. 108, no. 6, p. E98.
Abstract: OBJECTIVE: To evaluate the long-term
Abstract: OBJECTIVES: To explore practices and efficacy of infant hepatitis B (HB) immunization
attitudes of pediatricians toward administration of program on preventing hepatitis B virus (HBV)
the first dose of hepatitis B vaccine to infants, and infection, and to assess its impact on the incidence
to identify factors influencing the decision of of HB in children. METHODS: Since 1986, the
pediatricians to initiate immunization at birth universal HB vaccination for newborn babies with
versus at one to two months of age. METHODS: A standard, pediatric dose had been launched
random sample of 600 pediatricians obtained from without serologic prescreening of pregnant women
the American Academy of Pediatrics membership for HBsAg, in a high endemic county of Long-An.
database was surveyed by mail. RESULTS: Three A hepatitis surveillance system was set up to
hundred eighty (68%) of the 563 pediatricians who evaluate the possible impact on the incidence of
were located responded to the survey. Of these 380 hepatitis B. To serologically evaluate the
pediatricians, 279 provided routine immunizations effectiveness of the program, a stratified random
294
sampling of 1,000 children in 1987 birth cohorts, 0.39 to 2.38/100,000 in 2000 (chi-square=58.26,
who received plasma-derived HB vaccine, was P<0.01). The HBsAg carrying rate of the children
recruited for long-term follow up at the age of decreased from 2.82% to 0.60%, about 80.00%
1 to 13 years. A cross-sectional seroepidemiological after vaccination (chi-square=10.75, P<0.01).
survey was conducted in the county in 1985, CONCLUSION: Hepatitis B vaccination of
before the program, and in 2001, for newborn babies is an effective measure for
1,551 children born in 1996–2000 who were prevention and control of hepatitis B virus
administered yeast recombinant HB vaccine. infection.
RESULTS: During the one to 13 years after the
program, the rates of HBsAg-positive were 0.7% to
2.9% with an average of 1.7% and the protective Hamdani-Belghiti, S. and N. L. Bouazzaou. 2000.
rates were 83.5% to 96.6%. HBV infection rates “Mother-child transmission of hepatitis B virus.
were 1.1% to 5.1% with an average of 2.4% and State of the problem and prevention,” Arch.
the protective rates were 93.5% to 98.4%. For the Pediatr., vol. 7, no. 8, pp. 879–882.
population aged 1 to 4 years who were immunized Abstract: Hepatitis B virus (HBV) infection is a
with recombinant HB vaccine, HBsAg positive worldwide problem of public health. Mother/child
rates were 1.8% to 2.4% with an average of transmission of the virus represents a major factor
2.0% and the protective rates were 78.4 to 85.2%. in maintaining the infection, which is often
Fourteen years after the program, the cumulative transmitted during delivery, the risk of transmission
incidence of acute hepatitis B in the children aged 1 of the HBV depending on the degree of maternal
to 14 years fell to 1.5 cases per 100,000 children, infectiosity, the genomic type of the virus, and the
down 91.8% as compared with that in 1985 to rate of maternal antibodies. Evolution towards
1987. However, the cumulative incidence of 14.4 chronicity of the infected newborn is frequent. The
cases per 100,000 population in unvaccinated available means to prevent the mother/child
children was not significantly different from that in transmission of the virus are efficient. Once HBV
the history controls. Acute hepatitis B children had maternal infection is diagnosed during pregnancy,
not been reported, showing that the vaccination joint administration of vaccine and specific
program was 100% protective in children. immunoglobulins to the baby in the early neonatal
CONCLUSION: The universal infant HB period efficiently prevent the mother/child
vaccination program in a hyperendemic area has transmission of the virus.
proved to be effective in controlling HBV infection
and decreasing the incidence of acute hepatitis B in
children. Booster dose is unnecessary in 13 years “Hepatitis B vaccine encouraged for all newborn
after the immunization. The protective efficacy of infants...and do multiple vaccines overwhelm a
yeast recombinant HB vaccine is similar to that of child’s immune system?” 2002. Child Health
plasma-derived HB vaccine. Alert, vol. 20, p. 1.
Gong, X. H., L. R. Liu, L. Jia, Y. H. Li, Y. L. Xing, Ip, H. M., V. C. Wong, , P. N. Lelie, H. W.
and Q. Y. Wang. 2003. “Epidemiological effect Reesink, W. Schaasberg, C. Y. Yeung, and H. K.
of hepatitis B immunization among newborn Ma. 1989. “Hepatitis B infection in infants
babies in Beijing,” Zhonghua Gan Zang. Bing. after neonatal immunization,” Acta. Paediatr.
Za Zhi., vol. 11, no. 4, pp. 201–202. Jpn., vol. 31, no. 6, pp. 654–658.
among newborn babies in Beijing. METHODS: A 235 babies born to chronic hepatitis B, HBeAg
multistage sampling method was used for the carriers was carried out. Babies in three treatment
collection of immunization cards, field groups all received heat-inactivated hepatitis B
epidemiological survey on hepatitis B virus (HBV) vaccine. In addition multiple doses of HBIG and a
immunization of children, analysis of infectious single dose of HBIG were given in groups I and II
disease reports. HBsAg, anti-HBs and anti-HBc respectively. After three years of follow-up,
levels were detected by solid phase 4/60 (Group I), 3/64 (Group II), and 1/64 (Group
radioimmunoassays (SPRIA). RESULTS: The III) developed chronic infection. For those who
incidence of hepatitis B in children of zero to escaped chronic infection, other hepatitis events
14 years at the beginning of HBV immunization also occurred. They were transient HBs-
was 18.59 to 20.52/100,000, and declined to antigenaemia, anti-HBc conversion and significant
rise in anti-HBs titre without seroconversion for
295
anti-HBc. It was deduced that 30% of babies born Abstract: BACKGROUND: Hepatitis B virus
to hepatitis carriers are naturally protected from (HBV) infection and its complications are among
chronic infection. Immunization, with vaccine only, the most common diseases in Iran. National mass
protects another 46%. The addition of single and vaccination of neonates against hepatitis B was
multiple doses of HBIG protects another 10% and started in 1991, but was considered a costly
5%, respectively. Two percent acquired intrauterine venture. AIM: To compare the efficacy of low-dose
infection and 7% failed to respond to the most intradermal HBV recombinant vaccine with
intensive immunization schedule. standard intramuscular dose in neonates.
METHOD: One hundred and sixty-five apparently
healthy neonates born in Shiraz were randomized
Lanckriet, C., D. Levy-Bruhl, E. Bingono, R. M. to receive either 10 microg [corrected] of
Siopathis, and N. Guerin. 1995. “Efficacy of recombinant vaccine intramuscularly (IM; n=82) or
BCG vaccination of the newborn: evaluation by 2 microg [corrected] vaccine intradermally (ID;
a follow-up study of contacts in Bangui,” Int. J. n=83) at months zero, one and six. Anti-HBs titers
Epidemiol., vol. 24, no. 5, pp. 1042–1049. were measured at 6 and 18 months after the first
Abstract: BACKGROUND: The efficacy of Bacillus dose. RESULTS: Fifty-three and 51 neonates in the
of Calmette and Guerin (BCG) vaccination given at IM and ID groups, respectively, completed the
birth is still controversial. We therefore conducted study. Protective anti-HBs titers (>10 IU/L) at
a study in Bangui (Central African Republic) to 18 months after the first dose were achieved in
estimate the protection afforded over the first seven 98.1% and 96.2% of neonates in IM and ID
years of life by BCG administered at birth. groups, respectively (p=ns). The only side effect in
METHODS: One thousand children who had lived the ID group was local hyperpigmentation, which
in contact with a recently diagnosed case of was seen in 55%; no significant side effect was
contagious tuberculosis were followed up for a reported in the IM group. CONCLUSION:
period of six months in order to detect the Intradermal vaccination with 20% of standard
occurrence of tuberculosis. Diagnosis of dose is as effective as IM vaccination when
tuberculosis was made through a scoring system. evaluated at 18 months after the first dose.
Vaccine efficacy (VE) was calculated on the basis of
the relative risk of contracting tuberculosis
Lehmann, D., W. S. Pomat, B. Combs, T. Dyke,
according to vaccination status. RESULTS: The
and M. P. Alpers. 2002. “Maternal
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
296
serotypes five and 23F were significantly higher in BCG vaccine or placebo. The vaccines as well as
children of immunized women than in the the placebo were obtained from BCG Laboratory,
unimmunized group up to age two months and for Madras. In order to assess the post-vaccination
serotype 14 significantly higher to age four months. allergy at various intervals after vaccination the
Maternal immunization did not significantly affect babies were tested with five IU of PPD-S from
the children’s capacity to make antibody responses 5 January 1976 to 25 March 1976 by home visits.
to immunization with Pnc PS vaccine in infancy. About 80% of babies were available for testing
The findings of this study and those in several after three to five months but only 50% after
other developing countries provide support for the 12–13 months. There was considerable waning of
concept of Pnc PS maternal immunization and post-vaccination allergy during a period of 12
justify the planning of large-scale efficacy trials. months. The mean size of scar did not differ
significantly for the two doses at the three
intervals. The difference in size of mean post-
MacIntyre, C. R. 2001. “Hepatitis B vaccine: risks vaccination allergy between full dose and half dose
and benefits of universal neonatal vaccination,” of the freeze-dried vaccine, though statistically
J. Paediatr. Child Health, vol. 37, no. 3, significant, was small (0.5mm). There were not
pp. 215–217. many complications like BCG adenitis either with
Abstract: Global eradication of hepatitis B, which the full or the half dose. It would appear desirable
has infected over 2,000 million people worldwide, to vaccinate babies with 0.1mg/0.1ml dose of
is an achievable goal. Hepatitis B vaccine is vaccine, in contrast to the present general practice
effective and safe, and is recommended in Australia of vaccinating them with half the dose.
as a four-dose childhood schedule commencing
with a neonatal dose. A neonatal dose has a greater
Prakash, C. 2003. “Crucial factors that influence
impact on carriage, the main reservoir of
cost-effectiveness of universal hepatitis B
transmission, due to the inverse relationship of age
immunization in India,” Int. J. Technol. Assess.
and risk of chronic carriage. Universal vaccination
Health Care, vol. 19, no. 1, pp. 28–40.
is clearly cost-effective in countries of high hepatitis
B endemicity but less so in countries of low Abstract: This study examines the parameters
endemicity. Other factors affecting the perceived crucial to cost-effectiveness of universal hepatitis B
benefits of universal vaccination in low-risk immunization in India. An incremental cost-
countries include the use of the preservative effectiveness analysis was done using a decision
thiomersal in hepatitis B vaccines, and case reports tree (Markov model) to follow up a hypothetical
of multiple sclerosis (MS) and unexplained fever in cohort of 100,000 newborns for the effects of
recipients. Careful epidemiological studies have hepatitis B acquired vertically at birth. The
failed to confirm any risk of MS or fever with the measure of effectiveness was disability-adjusted
hepatitis B vaccine, which is now thiomersal-free. life-years gained. Uncertainty analysis and Scenario
Other arguments against universal vaccination analysis were done using Latin hypercube
include “unnecessary” vaccination of low-risk sampling. Hepatitis B endemicity is the most
neonates. However, selective vaccination programs important factor, followed by the cost of vaccine.
targeting at-risk neonates are often poorly Other factors of some influence are vaccination
implemented and do not protect against horizontal coverage, vaccine efficacy, HBeAg positivity, and
transmission in early childhood. Universal vaccine wastage.
vaccination, which is safe and effective, is the only
practical means of achieving global eradication of
hepatitis B. Schoub, B. D., S. Johnson, J. McAnerney, L.
Gilbertson, K. I. Klaassen, and S. G. Reinach.
NEWBORN IMMUNIZATION
297
countries with moderate-to-good immunization Tidjani, O., A. Amedome, and H. G. ten Dam.
coverage but with suboptimal standards of 1986, “The protective effect of BCG
environmental sanitation. Monovalent type 1 vaccination of the newborn against childhood
vaccine has a considerably better chance of tuberculosis in an African community,”
achieving early, solid type 1 immunity because of Tubercle., vol. 67, no. 4, pp. 269–281.
the lack of interference from the more dominantly
Abstract: The latest controlled trial of BCG
immunogenic type 2 vaccine. In addition to
vaccination in southern India showed that two
significantly reducing an important source of
vaccines failed to confer protection against
susceptibles from the community, early immunity
pulmonary tuberculosis. This result cast serious
would be a major factor in removing a significant
doubt on the effectiveness of BCG vaccination of
pool of wild type 1 virus.
the newborn, which is widely applied in developing
countries. Therefore, WHO initiated a global
Sood, A., D. Singh, S. Mehta, V. Midha, and R. research study to evaluate current programs in
Kumar. 2002. “Response to hepatitis B vaccine developing countries. Part of this study was carried
in preterm babies,” Indian J. Gastroenterol., out in Lome, Togo, in which child contacts of
vol. 21, no. 2, pp. 52–54. newly detected patients were followed up with
clinical and radiological examinations. All
Abstract: INTRODUCTION: A well-accepted observations were recorded according to a scoring
vaccination schedule for preterm babies is not system. Concomitant observations were made to
available. We therefore studied the response to verify the comparability of the vaccinated and
hepatitis B vaccine in preterm babies. METHODS: unvaccinated children. Of the child contacts of
Sixty babies born to HBsAg-negative mothers were 352 index cases, 1,421 completed the
studied. Group I (n=20) consisted of term babies examinations. The distribution of the final score
with birthweight >2.5Kg, group II (n=20) included made it possible to distinguish 175 children likely
preterm babies with birthweight between 1.8Kg to suffer from tuberculosis: 113 among the 546
and 2.49Kg, and group III (n=20) included preterm unvaccinated and 62 among the 875 vaccinated
babies with birthweight between 1.2Kg and children. Significant incomparability was observed
1.79Kg. Mean gestational age in the three groups in respect of intensity of exposure: the vaccination
was 38.5 (1.1), 33.5 (1.4) and 32.7 (2.1) weeks, coverage was relatively low, and the risk of disease
respectively. All babies received three doses relatively high, if a parent was the index case or
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
(10 microg/0.5mL) of a recombinant HBV vaccine the child shared the bedroom of the index case
within three days of birth, and at six weeks and six (which very often coincided). The other variables
months of life. Anti-HBs levels were measured one studied, including age and sex, turned out to be
month after the second and third doses each; the practically irrelevant as regards comparability. The
immune response was categorized as good estimate of the protective effect against all types of
responders (anti-HBs >100 mIU/mL, low tuberculosis combined is 61.5%, which is slightly
responders (anti-HBs 10–100 mIU/mL) and non- lower than suggested by the raw data (66%). The
responders (anti-HBs <10 mIU/mL). RESULTS: protective effect, however, appeared to increase
Good antibody response after the second dose was considerably with severity of disease. In children of
seen in 95% of babies in group I, 60% of those in five years and older it was lower than in the
group II, and 10% of those in group III. This younger children. Tuberculin testing failed to reveal
increased to 100%, 90%, and 45%, respectively any sensitivity induced by BCG in the vaccinated
after the third dose. The response was influenced children. The distribution of the tuberculin
by gestational age (r=0.73); 94% of babies with reactions correlated poorly with the other
gestational age 34–36 weeks attained good diagnostic findings. Small reactions were only
antibody response compared to only 55% of babies slightly more frequent in healthy than in sick
with gestational age of 31–33 weeks. Birthweight children; only the very large reactions were
had no independent influence on the antibody associated with a higher risk of disease. This
response. CONCLUSION: The response to confirms that the tuberculin test is of very limited
hepatitis B vaccine is influenced by gestational age. diagnostic value in young children.
Hence, in preterm babies, it is advisable to check
antibody titers one month after the third dose to
assess the need for a booster dose.
298
Miscellaneous Issues
Bobadilla, J. L. and G. J. Walker. 1991. “Early transepidermal water loss over time following
neonatal mortality and cesarean delivery in acute barrier disruption by tape-stripping) and
Mexico City,” Am. J. Obstet. Gynecol., ultrastructure was determined. A single application
vol. 164, no. 1 Pt 1, pp. 22–28. of sunflower seed oil significantly accelerated skin
barrier recovery within one hour; the effect was
Abstract: The relationship between cesarean
sustained five hours after application. In contrast,
delivery and neonatal mortality is presented with
the other vegetable oils tested (mustard, olive and
information from 292 early neonatal deaths (cases)
soybean oils) all significantly delayed recovery of
and 3,098 survivors (controls) born in 25 hospitals
barrier function compared with control- or
in Mexico City during the summer of 1984. The
Aquaphor-treated skin. Twice-daily applications of
overall rate of cesarean delivery was 27%.
mustard oil for seven days resulted in sustained
Variations between health agencies and different
delay of barrier recovery. Moreover, adverse
social groups were not related to obstetric risk,
ultrastructural changes were seen under
suggesting that a sizable proportion of the
transmission electron microscopy in keratin
operations were probably unjustified. Babies of
intermediate filament, mitochondrial, nuclear, and
normal birthweight (greater than or equal to
nuclear envelope structure following a single
2,500g) delivered by cesarean section were
application of mustard oil. Conclusion: Our data
2.5 times more likely to die in the early neonatal
suggest that topical application of linoleate-
period compared with vaginally delivered babies of
enriched oil such as sunflower seed oil might
the same weight. The excess of mortality could not
enhance skin barrier function and improve
be explained by the effect of maternal
outcome in neonates with compromised barrier
characteristics or complications or by differences in
function. Mustard oil, used routinely in newborn
birthweight or gestational age. It is suggested that
care throughout South Asia, has toxic effects on
the conditions under which the operation was
the epidermal barrier that warrant further
performed probably explain the increased risk of
investigation.
early neonatal death. It is likely that poor quality
of resuscitation and respiratory care are implicated
in the link between “unnecessary” cesarean section Faucher, M. A. and G. Jackson. 1992.
and early neonatal mortality. “Pharmaceutical preparations. A review of
drugs commonly used during the neonatal
period,” J. Nurse Midwifery, vol. 37, no. 2
Darmstadt, G. L., M. Mao-Qiang, E. Chi, S. K.
Suppl, pp. 74S–86S.
Saha, V. A. Ziboh, R. E. Black, M. Santosham,
and P. M. Elias. 2002. “Impact of topical oils Abstract: Certified nurse-midwives, whose
on the skin barrier: possible implications for responsibility includes care of the newborn in the
neonatal health in developing countries,” Acta first days of life, should be well versed in the
Paediatr., vol. 91, no. 5, pp. 546–554. commonly used pharmaceutical preparations in the
neonatal period. This article reviews therapeutic
Abstract: Topical therapy to enhance skin barrier
uses and the pharmacodynamics of vitamin K, as
function may be a simple, low-cost, effective
well as the neonatal eye preparations for
strategy to improve outcome of preterm infants
prophylaxis of infections (silver nitrate,
with a developmentally compromised epidermal
tetracycline, and erythromycin ophthalmic
barrier, as lipid constituents of topical products
ointments). Preparations used in caring for the
may act as a mechanical barrier and augment
MISCELLANEOUS ISSUES
299
Fernandez, A., S. Patkar, C. Chawla, T. Taskar, Pulmonary localization of the TB and late start of
and S. V. Prabhu. 1987. “Oil application in the treatment in the mothers increase the risk of
preterm babies—a source of warmth and perinatal death and neonatal morbidity.
nutrition,” Indian Pediatr., vol. 24, no. 12, CONCLUSIONS: Children born to women with
pp. 1111–1116. TB have an increased risk of morbidity and
mortality in the neonatal period.
Abstract: In a controlled study on 50 preterms,
corn oil was applied every four hours to the entire
body in 25 babies and an equal number matched Goodwin, R. M., A. Armstrong, J. Bertram, and B.
for weight and gestational age served as controls. Stewart. 1988. “Springtime in Ayrshire: home
Rectal temperatures were monitored and weighing of neonates with a new direct
maintained when necessary with a warmer. Both recording scale,” Public Health, vol. 102, no. 4,
groups were fed with breastmilk and nursed in the pp. 335–347.
same nursery. Fasting serum triglycerides were
estimated in both groups prior to starting the study Abstract: Regular weighing of babies and children
and at the end of the 72 hours. The study group is an important aspect of growth monitoring.
required use of the warmer for significantly lesser Teaching Aids at Low Cost (TALC), a charity
number of hours (P<0.001) as compared to the producing and distributing books, slide sets and
controls. The serum triglyceride levels also rose growth monitoring equipment for health workers
significantly (P<0.01) in the study group. in developing countries, has recently launched a
new type of simple spring balance. This uses a
spring of comparable accuracy to those in more
Figueroa-Damian, R. and J. L. Arredondo-Garcia. complex weight scales, whose pointer can directly
2001. “Neonatal outcome of children born to indicate a child’s weight on its growth chart
women with tuberculosis,” Arch. Med. Res., mounted on the scale frame. It is available in
vol. 32, no. 1, pp. 66–69. 0–5kg and 0–17kg versions. The scale is designed
for home use by parents and health workers and
Abstract: BACKGROUND: As the incidence of
may help to promote community understanding of
tuberculosis (TB) has increased worldwide, it is
growth monitoring. The original field testing of the
expected that pregnant women will acquire this
“baby” (0–5kg) version of the scale was carried
infection more frequently. Mycobacterium
out by parents and health workers in Ayrshire. The
tuberculosis infection during pregnancy may
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
300
Grover, S. B., D. K. Taneja, A. Bhatia, and H. morbidity. RESULTS: Vital status was confirmed in
Chellani. 2000. “Sonographic diagnosis of 89% of infants in both groups at one year. There
congenital tuberculosis: an experience with four were 19 deaths in the control group and 7 in the
cases,” Abdom. Imaging, vol. 25, no. 6, vitamin A group (relative risk=0.36;
pp. 622–626. 95% confidence interval: 0.16, 0.87). The impact
was stronger among boys, infants of normal
Abstract: Abdominal sonography of four infants
compared with low birthweight, and those of
with pyrexia and hepatomegaly demonstrated
greater ponderal index. Among infants examined at
multiple hypoechoeic hepatic and splenic foci,
four months of age, the one-week period
guided biopsies of which showed caseating
prevalence of common morbidities was similar for
granulomas with acid-fast bacilli. Evidence of
vitamin A and control infants. However, during
tuberculosis in maternal endometrium and its
this same four-month period, 73% and 51% more
exclusion in the contacts further confirmed a
control infants were brought for medical treatment
diagnosis of congenital tuberculosis. Clinical
for cough (p=0.008) and fever (p=0.063),
suspicion supplemented by careful sonography
respectively. CONCLUSIONS: Neonatal vitamin A
facilitated early detection and antemortem
supplementation may reduce the infant mortality
diagnosis of this potentially fatal disease.
rate and the prevalence of severe respiratory
infection among young infants.
Hadley, G. P. and M. Mars. 2001. “Improving
neonatal transport in the Third World—
Lamont, R. F., P. D. Dunlop, P. Crowley, M. I.
technology or teaching?,” S. Afr. J. Surg.,
Levene, and M. G. Elder. 1983. “Comparative
vol. 39, no. 4, pp. 122–124.
mortality and morbidity of infants transferred
Abstract: Neonatal transport in the Third World in utero or postnatally,” J. Perinat. Med.,
remains hazardous because of a shortage of human vol. 11, no. 4, pp. 200–203.
and material resources. An audit of the
Abstract: The outcome of two hundred and twelve
transportation of 126 surgically ill neonates was
infants transferred in utero and delivered in the
undertaken to identify areas where improvement is
regional neonatal intensive care center is compared
possible. Failure to maintain simple interventions
with one hundred and sixty-six infants born
such as intravenous fluid replacement and
elsewhere and transferred neonatally to the same
nasogastric drainage were found to be more
unit, during the same period of time. The mean
important than inadequate technology in defining
birthweight (+/– 1 S.D.) was 1,391g (+/– 415g) for
the status of the patient on arrival. Investment in
the infants transferred in utero, and 1,398g (+/–
education is likely to pay greater dividends than
415g) for the infants transferred neonatally. The
further technological advances.
mean gestational age of the two groups was
29.9 completed weeks for both groups. Survival
Humphrey, J. H., T. Agoestina, L. Wu, A. Usman, was defined as discharge from the neonatal unit
M. Nurachim, D. Subardja, S. Hidayat, J. and intraventricular hemorrhage was diagnosed
Tielsch, K. P. West, Jr., and A. Sommer. 1996. ultrasonically. The survival rate was 83% for the
“Impact of neonatal vitamin A supplementation group transferred in utero and 70% for the group
on infant morbidity and mortality,” J. Pediatr., transferred postnatally (p<0.01). The incidence of
vol. 128, no. 4, pp. 489–496. intraventricular hemorrhage was 30% and 45%
respectively (p<0.01). Using birthweight specific
Abstract: OBJECTIVE: To determine whether perinatal mortality rates and intraventricular
vitamin A supplementation at birth could reduce hemorrhage rates of the neonatally transferred
infant morbidity and mortality. STUDY DESIGN: group for standardization, it can be calculated that
We conducted a placebo-controlled trial among 27 infants survived and 31 were protected from
MISCELLANEOUS ISSUES
2,067 Indonesian neonates who received either intraventricular hemorrhage because of in utero
52 micromol (50,000 IU) orally administered transfer. It is concluded that infants likely to
vitamin A or placebo on the first day of life. require neonatal intensive care have decreased
Infants were followed up at one year to determine mortality and morbidity if transferred in utero to a
the impact of this intervention on infant mortality. center with these facilities rather than being
A subgroup (n=470) was also examined at four transferred neonatally.
and six months of age to examine the impact on
301
Lawn, J. E., S. Reef, B. Baffoe-Bonnie, S. babies was 36.58 (+/– 0.21)°C; after incubator care
Adadevoh, E. O. Caul, and G. E. Griffin. 2000. it was recorded s 36.80 (+/– 0.10)°C in naked
“Unseen blindness, unheard deafness, and infants. The baseline core temperature of the
unrecorded death and disability: congenital clothed babies was 36.63 (+/– 0.21)°C while it was
rubella in Kumasi, Ghana,” Am. J. Public 37.01 (+/– 0.18)°C after two hours of incubator
Health, vol. 90, no. 10, pp. 1555–1561. care. An ambient air temperature of 33–34°C in
the incubator (thermoneutral temperature range for
Abstract: OBJECTIVES: Although rubella
these babies being 31.0–33.8°C) was achieved
serosusceptibility among women of reproductive
within 30–60 minutes of incubator stay (nursery
age in West Africa ranges from 10% to 30%,
temperature being 28 +/– 0.6°C). No evidence of
congenital rubella syndrome has not been reported.
carbon dioxide narcosis, hypoxia, acidosis, or
In Ghana, rubella immunization and serologic
adverse thermoregulatory behavior was observed.
testing are unavailable. Our objectives were to
One baby had hypoglycemia (blood sugar less than
identify congenital rubella syndrome cases,
35mg/dl) and another had sweating. There is a
ascertain rubella antibody seroprevalence during
scope for providing additional facilities like
pregnancy, and recommend strategies for
administration of oxygen, phototherapy, X-rays
congenital rubella syndrome surveillance.
through the incubator without disturbing the baby.
METHODS: Congenital rubella syndrome cases
were identified through prospective surveillance
and retrospective surveys of hospital records. A Narayanan, I. 1987. “Early Mother-Infant
rubella serosurvey of pregnant urban and rural interactions: Global Perspectives and
women was performed. RESULTS: Eighteen infants Developing Country Concerns,” J. Trop.
born within a five-month period met the congenital Pediatr., vol. 33, p. 120.
rubella syndrome case definitions, coinciding with
a nine-fold increase in presentation of infantile Abstract: The importance of early mother-infant
congenital cataract. The congenital rubella interaction has been recognized all over the world.
syndrome rate for this otherwise unrecorded This article reviews some of the reported influences
rubella epidemic was conservatively estimated to be on the bonding phenomenon and attendant
0.8 per 1,000 live births. A postepidemic rubella controversies in affluent societies. It also highlights
immunity rate of 92.6% was documented among the variation in developing countries in the
405 pregnant women; susceptibility was practices and impact related to this interaction, and
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
significantly associated with younger age (P=.000) presents practical guidelines for the involvement of
and ethnicity (northern tribes, P=.024). the mothers with the high risk neonates.
CONCLUSIONS: Congenital rubella syndrome
occurs in Ghana but is not reported. Information Narayanan, I. and A. M. Mitter. 1980.
about congenital rubella syndrome and rubella in “Experiences with a mother or mother figure in
sub-Saharan Africa is needed to evaluate inclusion a neonatal special care unit,” Indian Pediatr.,
of rubella vaccine in proposed measles control vol. 47, pp. 27–32.
campaigns.
Abstract: The effects of using the mother or a
female attendant to look after the infant in the
Malhotra, A. K., A. K. Deorari, V. K. Paul, A. neonatal special care unit were studied. There was
Bagga, and M. Singh. 1992. “A new transport a fall in mortality and a decreased occurrence of
incubator for primary care of low birthweight aspiration of feeds. The babies also appeared to be
babies,” Indian Pediatr., vol. 29, no. 5, more contented as evidenced by their being quieter.
pp. 587–593. There was no increase in the incidence of
Abstract: A new portable, cheap and indigenous infections.
incubator made of polystyrene has been devised for
delivery of primary health care services to the Narayanan, I., H. Kumar, P. K. Singhal, and A. K.
newborn babies in the community. Twenty six Dutta. 1991. “Maternal participation in the
babies with a mean weight of 1,726g (range care of the high risk infant: follow-up
1,388g–1,981g) and gestational age of 35.3 weeks evaluation,” Indian Pediatr., vol. 28, no. 2,
(range 34–38 weeks) were continuously evaluated pp. 161–167.
for two hours observation period, in naked and
clothed conditions. Rectal, abdominal skin, foot, Abstract: Fifty mothers of high risk infants
ambient air and nursery temperatures were admitted to the Neonatal Special Care Unit were
recorded. The baseline core temperature of the followed up to the postnatal age of 2.5 months +/–
302
15 days. Twenty-five mothers (Group I) had stayed scores was used to measure physiologic
in the nursery with the infant for a period of organization, motor organization, self-regulation,
4.8 +/– 4.6 days until the discharge of the infant, and need for caregiver facilitation during transfer
providing expressed milk and participating in the to and from the parent and during pre, post, and
non-specialized care of the infant. The other skin-to-skin periods. RESULTS: Temperature
25 mothers (Group II) remained separate from remained stable. Oxygen saturation decreased and
their babies for the duration of the latter’s stay in heart rate increased when the infant was
the hospital although some of the mothers did transferred to and from the parent, but returned to
come off and on to give expressed human milk and baseline levels during and after skin-to-skin care
at times handle their infants. Family features such regardless of the transfer method. Infants showed
as parental age, educational and occupational more physiologic and motor disorganization, less
status, and presence of residential elder women, self-regulation, and more need for caregiver
were similar in the two groups. Infant facilitation during transfers to and from the parent
characteristics too, such as sex, birthweight, and than during the pre, post, and skin-to-skin care
early neonatal morbidity were also comparable. periods. CONCLUSIONS: Both transfer methods
Operative deliveries and maternal problems were resulted in physiologic disorganization. However,
as expected more in the separated group. The during and after skin-to-skin care, infants exhibited
duration of the infants’ hospital stay was also more no signs of energy depletion.
in the latter (9.5 +/– 3.5 days vs. 6.3 +/– 3.9 days;
p>0.05). Subsequent to their discharge, mothers
who had stayed with the infant identified the Rutter, N. and D. Hull. 1981. “Reduction of skin
following benefits of their stay—acquiring of water loss in the newborn. I. Effect of applying
knowledge relevant to infant care especially topical agents,” Arch. Dis. Child, vol. 56, no. 9,
hygiene (19) and their personal involvement in the pp. 669–672.
care of their infant (12), both of which they said Abstract: The waterproofing effect of a number of
increased their self confidence in looking after the creams, oils, and greases was examined by
babies after discharge, and provision of breastmilk measuring water loss from adult skin before and
round the clock (17). after topical application. Creams had a high water
content and were ineffective, oils produced a
modest fall in water loss, but paraffin in grease
Neu, M., J. V. Browne, and C. Vojir. 2000. “The
form had a pronounced, sustained waterproofing
impact of two transfer techniques used during
effect. A paraffin mixture (80% soft, 20% hard
skin-to-skin care on the physiologic and
paraffin (BP) was then applied to the skin of three
behavioral responses of preterm infants,” Nurs.
preterm babies nursed naked in incubators. Overall
Res., vol. 49, no. 4, pp. 215–223.
skin water loss fell by 40% to 60% after
Abstract: BACKGROUND: Conservation of energy application and was still lower than pretreatment
assumes an important role in the care of infants levels six hours later. The topical application of
requiring assisted ventilation, yet little research has paraffin offers a new approach to reduction of the
been conducted on this group of infants in terms of high evaporative water and heat losses of preterm
thermoregulation, oxygenation, heart rate, or sleep babies.
states during skin-to-skin care. OBJECTIVES: To
compare the impact of two different transfer
techniques used in skin-to-skin care (nurse transfer Singh, H., D. Singh, and B. K. Jain. 1996.
and parent transfer) on physiologic stability and “Transport of referred sick neonates: how far
other descriptive measures of physiologic stability from ideal?” Indian Pediatr., vol. 33, no. 10,
related to energy conservation in ventilated preterm pp. 851–853.
infants during and after skin-to-skin care. Abstract: Transport of sick neonates is far from
MISCELLANEOUS ISSUES
METHOD: Fifteen ventilated preterm infants ideal in the region and needs attention.
weighing a mean of 1,094g were randomly Pretransport workup does not exist and no data is
assigned to receive either parent or nurse-to-parent available regarding the condition prior to
transfer on the first of two consecutive days and transport. The transport facilities are poor and
the alternate method the following day. temperature instabilities occur during transport.
Temperature was taken before and after skin-to- Various factors may be responsible for this
skin care. Oxygen saturation and heart rate were situation like lack of awareness, financial
recorded minute by minute, and the Assessment of constraints, improper road conditions and lack of
Behavioral Systems Observation (ABSO) scale skilled manpower (1, 6–9). Outreach educational
303
programs should be organized to educate the Abstract: This report summarizes the deliberations
personnel involved in the neonatal care. The of a technical working group on the care of sick
importance of early at risk identification, in utero newborns convened by the World Health
transport, pretransport stabilization and role of Organization in Ankara, Turkey, in June 1995.
skilled manpower during transport needs to be Emphasis was placed on the clinical management
stressed upon during educational programs. of the most common and severe early neonatal
Feedback to the referring doctors incorporating diseases that can be treated with limited resources
suggestions for future referrals would go a long in the community, health center, or referral
way in eliminating the more easily preventable hospital. For the purposes of management at the
adverse factors. health center, diseases were grouped into four
categories based on urgency and similarity of signs
and management: severe bacterial infection, local
UNICEF. 2001. The state of the world’s children bacterial infection, severe jaundice, and inability to
2001: early childhood development. feed. The most important element of newborn care
Abstract: What happens during the very earliest at the health center level is the identification of
years of a child’s life, from birth to age signs that suggest severe disease and referral of the
3, influences how the rest of childhood and newborn to the hospital. Workshop proceedings
adolescence unfolds. Yet, this critical time is usually are summarized in four tables: 1) the most
neglected in the policies, programs and budgets of common newborn diseases in the first week of life,
countries. Drawing on reports from the world over, the presenting signs, diagnostic category, and
The State of the World’s Children 2001 details the possible associated maternal complications;
daily lives of parents and other caregivers who are 2) danger signs in the first week of life that can be
striving—in the face of war, poverty and the recognized by mothers, families, and health
HIV/AIDS epidemic—to protect the rights and meet workers; 3) assessment (ask, look, listen, feel) of
the needs of these young children. the newborn at the health center; and 4)
classification and identification of treatment at the
Available at: health center.
http://www.unicef.org/sowc01/
Available at:
http://www.who.int/reproductive-
World Health Organization. 1996. Management of health/publications/
SELECTED ANNOTATED BIBLIOGRAPHY ON NEWBORN HEALTH
304