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Acta Neurol Scand 2001: 104: 136–141 Copyright # Munksgaard 2001

Printed in UK. All rights reserved


ACTA NEUROLOGICA
SCANDINAVICA
ISSN 0001-6314

Predictors of discharge to home during the


first year after right hemisphere stroke
Jehkonen M, Ahonen J-P, Dastidar P, Koivisto A-M, Laippala P, Vilkki M. Jehkonen1,2, J.-P. Ahonen2,
J, Molnár G. Predictors of discharge to home during the first year after P. Dastidar3, A.-M. Koivisto4,
right hemisphere stroke. P. Laippala4, J. Vilkki5, G. Molnár2
Acta Neurol Scand 2001: 104: 136–141. # Munksgaard 2001. 1
University of Tampere, Department of Psychology,
and 2Tampere University Hospital, Department of
Objectives – The aim of this study was to explore predictive factors of the Neurology and Rehabilitation, Tampere, Finland;
3
length of hospital stay at the acute stage of right hemisphere stroke. Tampere University Hospital, Department of
Special attention was paid to the possible role of anosognosia for Diagnostic Radiology, Tampere, Finland; 4Tampere
hemiparesis and anosognosia for neglect in this prediction. Patients and School of Public Health, University of Tampere, and
Research Unit, Tampere University Hospital, Tampere,
methods – A consecutive series of 57 patients having their first right
Finland; 5University of Helsinki, Department of
hemisphere stroke were examined at the acute phase. Forty-nine patients Psychology, and Helsinki University Central Hospital,
were included in this study and followed-up for 12 months. The Department of Neurosurgery, Helsinki, Finland
examinations were conducted within 2 weeks of onset. The outcome
variable was the time (days) from stroke to discharge to home. The
predictors were age, gender, size of infarct, neglect, hemiparesis, verbal
memory, unawareness of illness, anosognosia for neglect, anosognosia
for hemiparesis and presence of a relative at home. Results – Hemiparesis Key words: cognitive disorders; stroke; discharge to
and unawareness of illness lengthened the duration of the hospital stay, home; neglect; anosognosia
the presence of a relative reduced it. Neglect was the best single predictor Dr Mervi Jehkonen, Tampere University Hospital, P.O.
of poor outcome, but it had no additional value in the combination of Box 2000, FIN-33521 Tampere, Finland
the three predictors above. Neither anosognosia for hemiparesis nor Tel.: +358 3 247 6498
anosognosia for neglect were important predictors. Conclusion – Fax: +358 3 247 5314
Hemiparesis, unawareness of illness and presence of a relative at home e-mail: klmeje@uta.fi
were the best predictors of the time from right hemisphere stroke to
discharge to home. Accepted for publication April 5, 2001

Independent living is often used as a measure of bisection did not contribute significantly to the
outcome after stroke. Patients’ dependence is most prediction of functional outcome.
typically defined in terms of the degree of physical Pedersen et al. (15) found that hemineglect per se
disability and impairment in activities of daily living had no independent influence on the discharge
(ADL) (1–8). It is evident that both cognitive Barthel Index or the rate of discharge to indepen-
impairments and sensorimotor defects increase the dent living in their large series of patients with right
likelihood of dependence after stroke (6, 7, 9–11). or left hemisphere stroke. In fact, they reported that
Earlier studies have usually included patients with anosognosia for hemiparesis and/or visual field
left and right hemisphere stroke. Severe hemiparesis defect has an independent influence on the rate of
and aphasia clearly restrict independent living (10, discharge to independent living (16). Gialanella &
12–14). Neglect, which is a typical cognitive deficit Mattioli (17) also found that anosognosia is the
after right hemisphere stroke, seems to make it more worst prognostic factor for motor and functional
difficult to regain independence in activities of daily recovery from left hemiplegia after stroke.
living (9) or return to home after discharge from The purpose of this study was to explore factors
hospital (8). Friedman (8) reported that patients connected with the return to home after right
with neglect in line bisection had poorer functional hemisphere stroke. The outcome variable was the
outcome as measured by Barthel ADL score, time from stroke to the discharge to home during a
walking speed and discharge residence than those 1-year follow-up. In particular, we wanted to find
with normal line bisection. However, accounting for out whether anosognosia has additional predictive
motor loss and the ability to draw a house, line value besides neglect and hemiparesis, as suggested

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Predictors of discharge to home

by Pedersen et al. (15, 16), and whether these and nine behavioural subtests (BITB). The conven-
predictive deficits might explain patients’ depen- tional subtests are line crossing, letter cancellation,
dency during the follow-up. star cancellation, figure and shape copying, line
bisection and representational drawing. The beha-
vioural subtests are picture scanning, telephone
Patients and methods dialling, menu reading, article reading, telling and
setting the time, coin sorting, address and sentence
Patients copying, map navigation and card sorting. Patients
Fifty-seven consecutive patients with acute right who scored under the original cutoff in at least two
hemisphere brain infarct were studied between of the six BITC subtests or patients scoring under
February, 1994 and March, 1998. They were the original cutoff (j67) in BITB subtests were
admitted to Tampere University Hospital as considered neglect patients (18).
emergency cases and treated at the Department of Unawareness of neglect was assessed by asking
Neurology. The patients with previous neurological the patient directly: ‘‘Do you have any difficulties
disorders, insufficient cooperation due to reduced observing any part of the space around you?’’ (21).
consciousness, severe primary visual impairment, If necessary, the patient was given the following
left-handedness and age over 75 years were alternatives: left side, right side, none or both sides.
excluded. Neuropsychological and neurological Our single question for the observation of anosog-
assessments were carried out within 10 days of nosia for neglect is comparable to the procedure of
onset (mean=6.1; SD=1.97; range=2–10). A Bisiach et al. (22) and Pedersen et al. (15, 16) for the
follow-up study was conducted 12 months after detection of moderate to severe anosognosia (for
onset. None of the patients had recurrent stroke hemiparesis and/or visual field defect).
during the 1-year follow-up. All patients were able Unawareness of illness and unawareness of
to manage independently in the activities of daily hemiparesis were assessed using Cutting’s (23)
living before the onset of stroke. Participation was questions. Patients were considered to be unaware
voluntary and all participants gave their written of illness if they gave inadequate answers to either
informed consent. The study was approved by the of the two questions: ‘‘Why are you here?’’ and
Ethical Committee of Tampere University Hospital. ‘‘What is the matter with you?’’.
One patient had developmental dyslexia that If patients with hemiparesis gave inadequate
clearly disturbed his performance in the Behav- answers to any of the following seven questions,
ioural Inattention subtests (18–20) requiring read- they were considered to be unaware of hemiparesis:
ing, but he did not show signs of neglect. He did not ‘‘Is there anything wrong with your arm or leg?’’;
have hemiparesis and he was discharged from the ‘‘Is it weak, paralyzed or numb?’’; ‘‘How does it
hospital 6 days after onset. This patient was feel?’’; (Arm picked up) ‘‘What is this?’’; ‘‘Can you
excluded from the further analyses. Five patients lift it?’’; ‘‘You clearly have some problem with
had infarction in the pons and they were also this?’’; (Asked to lift arms) ‘‘Can’t you see that your
excluded. Thus we had 51 patients in the acute two arms are not at the same level?’’.
examination. Two patients died during the 1-year Verbal memory was assessed with the Logical
follow-up. One of them returned home 4 days after Memory subtest (range=0–46 points) of the
stroke and this was considered his outcome. He Wechsler Memory Scale (WMS) (24).The outcome
lived independently until his death 11 months after measure was the time (in days) from stroke to being
stroke. The other patient remained in the hospital discharged to home.
and died 4.5 months after stroke. Her outcome was
considered a failure to return home. These 2
patients were included in the study, but their
Neurological and neuroradiological examinations
exclusion did not change the results. Two patients
were excluded from the analyses because they A neurological examination was performed on the
refused to participate in the 12-month follow-up same day as the neuropsychological assessment or
and therefore their discharge destination was not more than 1 day before or after that assessment.
unknown. Thus the total number of patients in The degree of motor defect was evaluated using the
this study was 49. NIH Stroke Scale (25, 26) at the acute stage (2–10
days) and 12 months after the infarct. Hemiparesis
was scored using a scale from 0 (=normal) to 4
Neuropsychological examination (=severe hemiparesis) for leg and arm separately,
Presence of neglect was determined with the and these scores were summed to give a range from
Behavioural Inattention test (BIT) (18–20). The 0 to 8. For statistical analyses hemiparesis scores
BIT consists of six conventional subtests (BITC) were dichotomized (cutoff score: 1): presence of

137
Jehkonen et al.

Table 1. Patients’ demographic and clinical characteristics at 10-day examination

Outcome at 1-year follow-up


Variables Total series Independent Dependent

Number of patients 49 47 2
Female gender 19 (39%) 17 2
Hemiparesis 14 (29%) 12 2
Anosognosia for hemiparesis 7 (14%) 5 2
Neglect (BITB) 13 (27%) 11 2
Neglect (BITC) 19 (39%) 17 2
Anosognosia for neglect (BITC) 13 (27%) 12 1
Unawareness of illness 6 (12%) 4 2
Relative at home 36 (73%) 35 1
Size of infarction (cm3): mean (SD) 58.7 (69.9) 51.5 (60.6) 229.0 (71.0)
Verbal memory (WMS): mean (SD) 19.8 (6.7) 20.4 (6.3) 7.5 (3.5)
Age: mean (SD) 62.6 (10.5) 62.2 (10.5) 73.5 (2.1)

Abbreviations: BITC=the conventional subtests of the Behavioural Inattention Test; patients scoring under the cutoff in at least two of the BITC subtests were considered
neglect patients. BITB=the behavioural subtests of the Behavioural Inattention Test; patients scoring under the cutoff (67) were considered neglect patients. WMS=Wechsler
Memory Scale; Logical Memory subtest.

hemiparesis was scored as 1, absence of hemiparesis infarct. Anosognosia for neglect and anosognosia
as 0. for hemiparesis were studied separately as predic-
Computed tomography of the brain was per- tors.
formed on all patients. Out of the 49 patients The predictive significance of each variable
included in the study 45 had also magnetic separately was determined with the Cox model.
resonance imaging of the brain. On average the Thereafter the best combination of predictors was
neuroradiological studies were carried out 6 days computed using the forward stepwise Cox model
after onset (SD=2.6; range=0–12). The sizes of the (probability of F to enter=0.05 and probability of F
infarctions were determined on the basis of the T2 to remove=0.10). The statistical analyses were
weighted MRI images by manual tracing, or when performed using SPSS/Win Version 9.0 Software
digital images were not available (n=10), on the (29).
basis of the CT images using a method described by
Broderick et al. (27).
Results
Table 1 describes the patients’ demographic and
Data analysis clinical characteristics. Forty-seven (96%) patients
The statistical analyses were performed with the returned home during the 12-month follow-up,
Cox regression model (28). The outcome variable and the time from stroke to returning home
was the number of days from the onset of stroke to varied from 3 to 177 days (mean=32.1 days;
returning home. The follow-up time was 1 year. The SD=41.8; median=10.0 days). Two (4%) patients
predictors were age, gender, presence of a relative (a did not return to home. Thirteen patients showed
person living with the patient), neglect, hemiparesis, anosognosia for neglect (according to BITC
verbal memory, unawareness of illness, and size of neglect criteria) reporting difficulties when obser-

Table 2. Prediction of returning home with each predictor variable separately

Predictor Hazard rate 95% CI for hazard rate P-value

Neglect (BITC) 0.21 (0.10, 0.44) <0.001


Neglect (BITB) 0.08 (0.03, 0.25) <0.001
Hemiparesis 0.14 (0.06, 0.32) <0.001
Size of infarction 0.99 (0.98, 0.99) 0.001
Unawareness of illness 0.16 (0.05, 0.53) 0.003
Gender (F vs M) 0.49 (0.25, 0.95) 0.034
Verbal memory (WMS) 1.04 (1.00, 1.08) 0.042
Relative at home 1.90 (0.98, 3.71) 0.059
Age 0.99 (0.97, 1.02) 0.682

Abbreviations: BITC=the conventional subtests of the Behavioural Inattention Test; patients scoring under the cutoff in at least two of the BITC subtest were considered
neglect patients. BITB=the behavioural subtests of the Behavioural Inattention Test; patients scoring under the cutoff (67) were considered neglect patients. WMS=Wechsler
Memory Scale; Logical Memory subtest. CI=confidence interval.

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Predictors of discharge to home

Table 3. Best set of predictors in the acute stage of right hemisphere infarct for The role of anosognosia for hemiparesis as a
returning home
predictor was also examined in the total series of 49
patients. For this purpose hemiparesis was categor-
95% CI
Predictors HR for HR P-value ized into three groups: 0=no hemiparesis, 1=hemi-
paresis without anosognosia, and 2=hemiparesis
Hemiparesis 0.05 (0.01, 0.16) <0.001 with anosognosia.The rest of the predictors were the
Unawareness of illness 0.10 (0.03, 0.42) 0.002
same as in Table 2. The results indicated that
Relative at home 2.64 (1.27, 5.51) 0.010
hemiparesis, unawareness of illness (HR=0.11;
Abbreviations: CI=confidence interval. HR=hazard rate. P=0.002; 95% CI: 0.03, 0.46), presence of a relative
(HR=3.15; P=0.004; 95% CI: 1.43, 6.92) and size
ving the left side. None of the patients reported of infarction (HR=0.99; P=0.05; 95% CI: 0.99,
difficulties observing the right or both sides in the 1.00) were the best predictors. Hemiparesis as such
first examination. No infarction was visualized in was a significant predictor, but anosognosia for
2 patients, but both of them had mild sensory and hemiparesis had no significant effect (‘‘hemiparesis
motor disorders in the acute phase. Eight patients without anosognosia’’ compared to ‘‘no hemipar-
had two right hemisphere infarcts. esis’’ HR=0.06; 95% CI: 0.01, 0.23 and ‘‘hemi-
Table 2 shows the significance of each predictor paresis with anosognosia’ compared to ‘‘no
alone. Neglect (BITC and BITB), hemiparesis, hemiparesis’’ HR=0.08; 95% CI: 0.02, 0.39).
size of infarction, unawareness of illness, female
gender and poor verbal memory were statistically
significant single predictors, which decreased the
possibility to return home and lengthened the Discussion
time of the stay in hospital or nursery home. The aim of the present study was to explore factors
Table 3 illustrates the best combination of associated with the time from right hemisphere
predictors, when age, gender, neglect (BITB or stroke to return to home during a 1-year follow-up.
BITC separately), hemiparesis, size of infarction, The best combination of predictors was hemipar-
unawareness of illness, verbal memory and esis, unawareness of illness, and the presence of a
presence of a relative were used as possible relative at home. Hemiparesis and unawareness of
predictors in the model. The significant predictors illness decreased and the presence of a close person
were hemiparesis, unawareness of illness and at home increased the likelihood of returning home
presence of a relative. Hemiparesis and unaware- soon. Moreover, neglect (BITB and BITC) and size
ness of illness decreased and the presence of a of infarction had predictive value as single vari-
relative increased the patients’ likelihood of being ables, but they were closely associated with
discharged to home soon after stroke. Neglect unawareness of illness and did not have indepen-
(BITC or BITB) was the most powerful predictor dent predictive value in the above mentioned
in the first phase, but when unawareness of illness predictor combination.
entered into the model, the significance of neglect Unawareness of illness was the only cognitive
vanished. All patients who were unaware of illness deficit included in the set of best predictors. There
in the acute stage (n=6) had also neglect were 6 patients who were unaware of the illness in
according to both neglect criteria, BITC and the acute phase, and they all also had neglect
BITB. according to both our neglect criteria, BITC and
We also examined whether anosognosia for BITB. They had larger infarctions than the patients
neglect and/or anosognosia for hemiparesis pre- who were aware of the stroke. Three of the patients
dicted return to home. The analyses were who were unaware of the illness had severe
computed separately for neglect patients (n=19, hemiparesis, 1 had moderate hemiparesis and 2
according to BITC) and hemiparetic patients had no motor impairment. It should be noted that
(n=14). Comparisons were made between those unawareness of the illness recovered rapidly. None
patients who were aware of the deficit (neglect or of the patients was unaware of the illness at the
hemiparesis) and those who were unaware of the 3-month follow-up (21). Consequently, unaware-
deficit. The results indicated that anosognosia for ness of illness cannot be the cause of long-term
neglect was not related to discharge to home dependence on constant help in daily living.
(P=0.40), but anosognosia for hemiparesis was Nevertheless, unawareness of illness is most prob-
(HR=0.28; P=0.05; 95% CI: 0.08, 0.98). Patients ably an indicator of severe stroke, causing persistent
with anosognosia for hemiparesis had a greater cognitive deficits and increasing the likelihood of
risk for a longer hospital stay than those who poor outcome after the awareness of illness becomes
were aware of their hemiparesis. adequate.

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Jehkonen et al.

Some previous studies (15–17) suggest that outcome measure is most probably more objective
neglect does not have independent prognostic than the self-evaluated index. Returning home
significance among other predictors of functional requires some basic skills and once the patient has
outcome. Indeed, Pedersen et al. (16) and Gialanella mastered these skills he or she can be discharged
& Mattioli (17) found that anosognosia primarily quite soon, especially if there is a relative to help.
decreased the likelihood of returning to indepen- However, the Frenchay Activities Index (31) also
dent living after stroke. Pedersen et al. (16) defined measures several outdoor activities which might
anosognosia as unawareness of hemianopia and/or reflect a wider range of abilities. It is therefore not at
unawareness of hemiparesis. Anosognosia for one all surprising that the acute predictors of the two
or both of these defects was evidently a powerful outcome measures differ in the same series of
predictor, but this analysis did not reveal the patients.
predictive significance of anosognosia for each of Depression is a frequent consequence of stroke,
the defects separately compared to the predictive which might be associated with poor long-term
significance of the visual field or motor defect itself outcome (32, 33); however this was beyond the
without anosognosia. In our series, which only scope of our study. We were primarily interested in
included patients with right hemisphere infarct, the predictive value of acute disorders.
anosognosia for neglect did not have a significant Measurement of depression a few days after
role in the prediction of returning home. The stroke would probably produce highly unreliable
patients who were unaware of hemiparesis had results because this disorder usually develops
significantly poorer outcome than those who were several weeks or months after onset. The result of
aware of hemiparesis, but anosognosia for hemi- this study suggests that at the acute stage of right
paresis did not increase the accuracy of the best hemisphere stroke motor functioning is the most
predictor combination. important factor in the evaluation of patients’
According to our previous study (30) neglect in discharge to home. Cognitive factors seem to have a
acute right hemisphere stroke is an important less important role in this prediction. However,
unawareness of illness that was associated with
predictor of poor functional recovery measured
severe neglect lengthened the patients’ hospital stay.
with the Frenchay Activities Index (31), in which
patients evaluate their level of functional activity.
This subjective evaluation was best predicted by
neglect (BITB) and age. In the present study, using Acknowledgements
the time from stroke to discharge to home as an This study was supported by grants from the Medical
outcome measure, neglect (BITC or BITB) reached Research Fund of Tampere University Hospital, the Finnish
Cultural Foundation, the Scientific Research Fund of the
statistical significance only as a single predictor, but City of Tampere and the Finnish Graduate School of
it did not improve the accuracy of the best Psychology.
combination of predictors, namely hemiparesis,
unawareness of illness and presence of a relative.
Our outcome variable – the time from stroke to
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