PMID- 26063214

OWN - NLM
STAT- MEDLINE
DCOM- 20151114
LR - 20230906
IS - 1000-467X (Print)
IS - 1944-446X (Electronic)
IS - 1944-446X (Linking)
VI - 34
IP - 6
DP - 2015 Jun 10
TI - TLR3 gene polymorphisms in cancer: a systematic review and meta-analysis.
PG - 272-84
LID - 10.1186/s40880-015-0020-z [doi]
LID - 19
AB - INTRODUCTION: Recent studies examining the association of Toll-like receptor
3
(TLR3) gene polymorphisms with the risk of developing various types of cancer

have reported conflicting results. Clarifying this association could advance

our
knowledge of the influence of TLR3 single nucleotide polymorphisms (SNPs) on
cancer risk. METHODS: We systematically reviewed studies that focused on a
collection of 12 SNPs located in the TLR3 gene and the details by which these

SNPs influenced cancer risk. Additionally, 14 case-control studies comprising

a
total of 7997 cases of cancer and 8699 controls were included in a meta-
analysis
of 4 highly studied SNPs (rs3775290, rs3775291, rs3775292, and rs5743312).
RESULTS: The variant TLR3 genotype rs5743312 (C9948T, intron 3, C>T) was
significantly associated with an increased cancer risk as compared with the
wild-type allele (odds ratio [OR]=1.11, 95% confidence interval [CI]=1.00-
1.24,
P=0.047). No such association was observed with other TLR3 SNPs. In the
stratified analysis, the rs3775290 (C13766T, C>T) variant genotype was found
to
be significantly associated with an increased cancer risk in Asian
populations.
Additionally, the rs3775291 (G13909A, G>A) variant genotype was significantly

associated with an increased cancer risk in Asians, subgroup with hospital-

based
controls, and subgroup with a small sample size. CONCLUSION: After data
integration, our findings suggest that the TLR3 rs5743312 polymorphism may
contribute to an increased cancer risk.
FAU - Wang, Ben-Gang
AU - Wang BG
AD - Department 1 of General Surgery, the First Affiliated Hospital of China
Medical
University, Shenyang, Liaoning, 110001, Peoples Republic of China.
wangbengang2008@163.com.
FAU - Yi, De-Hui
AU - Yi DH
AD - Department 1 of General Surgery, the First Affiliated Hospital of China
Medical
University, Shenyang, Liaoning, 110001, Peoples Republic of China.
ydh1900@sina.com.
FAU - Liu, Yong-Feng
AU - Liu YF
AD - Department 1 of General Surgery, the First Affiliated Hospital of China
Medical
University, Shenyang, Liaoning, 110001, Peoples Republic of China.
liuyongfengsubmit@163.com.
LA - eng
PT - Journal Article
PT - Meta-Analysis
PT - Systematic Review
DEP - 20150610
PL - England
TA - Chin J Cancer
JT - Chinese journal of cancer
JID - 101498232
RN - 0 (TLR3 protein, human)
RN - 0 (Toll-Like Receptor 3)
SB - IM
MH - Alleles
MH - Asian People
MH - Case-Control Studies
MH - Genetic Predisposition to Disease
MH - Genotype
MH - Humans
MH - Introns
MH - *Neoplasms
MH - Odds Ratio
MH - Polymorphism, Genetic
MH - *Polymorphism, Single Nucleotide
MH - Risk
MH - *Toll-Like Receptor 3
PMC - PMC4593388
EDAT- 2015/06/13 06:00
MHDA- 2015/11/15 06:00
CRDT- 2015/06/12 06:00
PHST- 2014/11/13 00:00 [received]
PHST- 2015/03/12 00:00 [accepted]
PHST- 2015/06/12 06:00 [entrez]
PHST- 2015/06/13 06:00 [pubmed]
PHST- 2015/11/15 06:00 [medline]
AID - 10.1186/s40880-015-0020-z [pii]
AID - 20 [pii]
AID - 10.1186/s40880-015-0020-z [doi]
PST - epublish
SO - Chin J Cancer. 2015 Jun 10;34(6):272-84. doi: 10.1186/s40880-015-0020-z.