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PPSD 1689336369
PPSD 1689336369
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As each successive layer in a DNN composes the outputs from the previous layer, features of the data
can be learned at varying levels of abstraction, allowing deeper models to recognize increasingly
complex patterns. T. It is possible to inspect the convolutional filters in a trained CNN, and although
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these levels of abstraction are not always arranged neatly across successive convolutional layers, a
hierarchy of features can often be clearly seen. 62 Such an ability to learn hierarchical features can be
useful in a variety of structural bioinformatics tasks, as information in biological data often exists at
about how and why these types of models can be so effective, as well as a
these successes within the field. 2. The contact prediction task and its
implications for deep neural network (DNN) models: Analyze why DNN
This article is not intended to be a detailed exposition of every key deep learning concept; our aim is
instead to provide CASP participants and observers with a working understanding of the most important
DNN architectures that have been successfully applied to the core problem areas in recent CASP
experiments. We will then discuss what advantages such models may have over those more
traditionally used in various areas. We will then end with some thoughts on why and how these models
work, their limitations, potential pitfalls, and their correct application. All discussion will be limited to
supervised learning models, as the most performant DNN models used in CASP so far have been of this
type. For example, in the field of protein structure prediction, DNN models have shown promising
results by accurately predicting contact maps between amino acid residues. These models utilize
advanced machine learning techniques and leverage large databases of protein structures to learn
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complex patterns and relationships. Despite the limited availability of homologous sequences for
certain target proteins, the deep learning algorithms can still capture important features and generalize
well to accurately predict contacts. However, it is crucial to consider potential biases in the training
https://link.springer.com/chapter/10.1007/978-3-319-50127-7_....
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899861/
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https://link.springer.com/chapter/10.1007/978-3-319-50127-7_....
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899861/
https://link.springer.com/chapter/10.1007/978-3-319-50127-7_....
Toward Holism: The Significance of Methodological Pluralism
https://www.ualberta.ca/~iiqm/backissues/2_3final/html/morse....
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899861/
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https://link.springer.com/chapter/10.1007/978-3-319-50127-7_....
https://www.ualberta.ca/~iiqm/backissues/2_3final/html/morse....
Ex
Recent developments in deep learning applied to protein ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899861/
ck
https://link.springer.com/chapter/10.1007/978-3-319-50127-7_....
Ki
https://www.ualberta.ca/~iiqm/backissues/2_3final/html/morse....
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899861/
https://link.springer.com/chapter/10.1007/978-3-319-50127-7_....
Toward Holism: The Significance of Methodological Pluralism
https://www.ualberta.ca/~iiqm/backissues/2_3final/html/morse....
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899861/
am
https://link.springer.com/chapter/10.1007/978-3-319-50127-7_....
https://www.ualberta.ca/~iiqm/backissues/2_3final/html/morse....
Ex
Recent developments in deep learning applied to protein ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899861/
ck
https://link.springer.com/chapter/10.1007/978-3-319-50127-7_....
Ki
https://www.ualberta.ca/~iiqm/backissues/2_3final/html/morse....