The document summarizes an expedition to Nadym, Yamalo-Nenets Autonomous District in April 2015. 30 women aged 40-64 living in Nadym were examined. The women were found to have higher than normal average cytotoxic cell (CD8+) levels at 56.66±2.49% and lymphoproliferative (CD10+) levels at 16.66±1.35%. Deficiencies of T-lymphocytes with CD3+ and CD5+ receptors were found in 96.66±3.26% and 100±3.31% of women respectively.
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Original Title
FEATURES OF IMMUNE REACTIONS IN WOMEN YAMALO-NENETS AUTONOMOUS DISTRICT OF THE CITY OF NADYM
The document summarizes an expedition to Nadym, Yamalo-Nenets Autonomous District in April 2015. 30 women aged 40-64 living in Nadym were examined. The women were found to have higher than normal average cytotoxic cell (CD8+) levels at 56.66±2.49% and lymphoproliferative (CD10+) levels at 16.66±1.35%. Deficiencies of T-lymphocytes with CD3+ and CD5+ receptors were found in 96.66±3.26% and 100±3.31% of women respectively.
The document summarizes an expedition to Nadym, Yamalo-Nenets Autonomous District in April 2015. 30 women aged 40-64 living in Nadym were examined. The women were found to have higher than normal average cytotoxic cell (CD8+) levels at 56.66±2.49% and lymphoproliferative (CD10+) levels at 16.66±1.35%. Deficiencies of T-lymphocytes with CD3+ and CD5+ receptors were found in 96.66±3.26% and 100±3.31% of women respectively.
ОСОБЕННОСТИ ИММУННЫХ РЕАКЦИЙ У ЖЕНЩИН ЯМАЛО- НЕНЕЦКОГО АВТОНОМНОГО ОКРУГА ГОРОДА НАДЫМА Федеральное агенство научных организаций ФАНО России ФГБУН Федеральный исследовательский центр комплексного изучения Арктики РАН ФГБУН ФИЦКИА РАН, лаборатория физиологии иммунокомпетентных клеток, Архангельск, Россия Резюме. Проведена экспедиция в город Надым Ямало-Ненецкого автономного округа (апрель, 2015г.). Обследовано 30 женщин, в возрасте 40-64лет, проживающих в г.Надым Ямало-Ненецкого автономного округа. Для обследованных женщин характерны повышенные уровни среднего содержания цитотоксических клеток (CD8+) у 56,66±2,49% и лимфопролиферации (CD10+) у 16,66±1,35%. Установлен дефицит содержания Т - лимфоцитов с рецепторами CD3+ и CD5+ у 96,66±3,26% и 100,00±3,31% лиц, соответственно. Ключевые слова: фенотипы лимфоцитов, Север.
The relevance of the work.
Yamalo-Nenets Autonomous Okrug (YNAO) as an area geographically relevant to the areas of high latitudes, is uncomfortable territory with intense natural and man-made pressures on human health, as reflected by a pronounced tension of the adaptive systems of the body. Life in the far North is accompanied by an increase of functional load on the body, thereby creating a risk of breach or loss of health. Uncompensated changes in the immune system – quantitative, qualitative, disorders of balance and interaction – lead to the depletion of reserve capacity and development of pathology. Immunological reactivity of inhabitants of the European North is characterized by high prevalence of ecologically dependent secondary immunodeficiencies. [3, p. 4; 2, p. 181; 1, p. 162; 4, p. 159]. Of interest is the study of the formation of regional features of the immune status. Materials and methods. Conducted the expedition in the town of Nadym in Yamalo-Nenets Autonomous district (April, 2015). We examined 30 women, aged 40-64лет living in the city of Nadym in Yamalo-Nenets Autonomous district. Blood for analysis was taken from the cubital vein in a volume of 6 ml. at 9-10 o'clock in the morning on an empty stomach. Blood sampling was carried out in vacutainer lithium heparin firms "IMPROVACUTER". Immunological studies conducted in the laboratory of physiology of immunocompetent cells of the Institute of physiology of natural adaptations, VICKIE RAS, Arkhangelsk. In the peripheral blood were determined: the concentration of lymphocyte phenotypes CD3+, CD5+, CD8+, CD10+. The content of lymphocyte phenotypes were determined using indirect immunoperoxidase reaction with monoclonal antibodies (NPC "Medbiospektr", Russia) in preparations of lymphocytes a type of "dried drop". Used the package of applied programs mathematical statistics "Statistica 6.0". Main results. The surveyed women in the city of Nadym in Yamalo-Nenets Autonomous district revealed a low content of T-lymphocytes with receptors of CD3+ and CD5+ (0,53±0,03109 KL/l and 0.47±0,03109 KL/l), the values are below the generally accepted physiological norms. Deficiencies in the contents set at 96,66±3,26% and 100.00±3,31% of people. The average content of lymphocytes with receptors on CD8+ is above the accepted physiological boundaries and makes 0.49±0,03109 cells/l, elevated concentrations of CD8+ installed 56,66±2,49% of the surveyed entities. The proliferative activity of CD10+ is equal to the average of 0.43±0,02109 C/l, it was found that increased values of this indicator was observed in 16,66±1,35% of women. Revealed a direct relationship between CD10+ and CD5+(r=0.63;p< 0.05); CD5+, and CD8+(r=0,72; p< 0.05); CD3+ and CD5+(r=0.68; p< 0.05); CD3+ and CD8+(r=0,66; p< 0.05). Thus, for the surveyed women in the city of Nadym in Yamalo-Nenets Autonomous district, 40-64 years, is characterized by higher levels of average content of cytotoxic cells (CD8+) 56,66±2,49% and lymphoproliferative (CD10+) from 16,66±1,35% . The deficit of T - lymphocytes with receptors of CD3+ and CD5+ 96,66±3,26% and 100.00±3,31%, respectively. The wide distribution of these immune imbalances among the surveyed women Yamalo-Nenets Autonomous district of the city of Nadym indicates the formation of regional features of the immune status by high cytotoxic activity, against the background of significant T-cell deficiency that likely is a compensatory reaction Список литературы. 1. Morozova O. S., Kabbani, S. M., Popovski E. V., Shchegoleva L. S. Physiological responses of lymphoid cells in women with hypertension in the North/ O. S. Morozov, S. M. Kabbani, E. V. Popovskaya, Shchegoleva L. S. // Russian journal of immunology. – 2016. –T. 10 (19). –№2(1). – S. 161-163. 2. Shchegoleva L. S., Shashkova E. Y. the Physiological role of cells CD4+, CD8+ and CD16+ in inhabitants of European North in the age 41-60 years of age /L. S. Shchegoleva, E. Shashkova, Y. // Russian journal of immunology. – 2014. – T. 8(17). –№2(1). – P. 180-182. 3. Shchegoleva L. S. spare capacity of immune homeostasis in humans in the North/ HP Shchegolev. - Ekaterinburg: Uroran, 2007. - 207с. 4. Odland J., Nieboer E. Human biomonitoring in the Arctic. Special challenges in a sparsely populated area // International Journal of Hygiene and Environmental Health. – 2012. –Vol. 215. –P. 159-167. Abstract. O. S. Morozova, L. S. Shchegoleva, M. S. Kabbani. FEATURES OF IMMUNE REACTIONS IN WOMEN YAMALO-NENETS AUTONOMOUS DISTRICT OF THE CITY OF NADYM Federal Agency of scientific organizations (FANO of Russia) Federal state budget institution of science, Federal research center for integrated study of the Arctic, Russian Academy of Sciences (INSTITUTE of VICKIE RAS), laboratory of physiology of immune cells, Arkhangelsk, Russia Conducted the expedition in the town of Nadym in Yamalo-Nenets Autonomous district (April, 2015). We examined 30 women, aged 40-64лет living in the city of Nadym in Yamalo-Nenets Autonomous district. For the surveyed women is characterized by higher levels of average content of cytotoxic cells (CD8+) 56,66±2,49% and lymphoproliferative (CD10+) from 16,66±1,35%. The deficit of T - lymphocytes with receptors of CD3+ and CD5+ 96,66±3,26% and 100.00±3,31%, respectively. Keywords: phenotypes of lymphocytes, North.
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