In the treatment of acne (post-acne) the scar capsule around the inflamed gland is - II and III trimester pregnancy;

destroyed, which contributes to its purification, reduction of the volume of scar tissue and - severe endocrine disorders;
skin smoothing. - severe neurotic disorders;
Use of the preparation - recurrent thrombophlebitis;
The preparation is recommended for the care of problematic and scarred skin after - individual intolerance to collagenase;
operations, wounds, burns, pyo-inflammatory skin diseases, acne. - age under 3 years old;
Scar treatment enzyme complex is intended for external use only. - impact on child growth zones.
Scar treatment enzyme complex has no age restrictions. Phonophoresis procedure
Scar treatment enzyme complex can be used with electrophoresis (see point 4), Before the procedure, dilute Scar treatment enzyme complex concentrate (see item 3).
phonophoresis (see point 5) and application (see point 6). Apply the diluted preparation to clean dry skin (0,1ml of Scar treatment enzyme complex
Scar treatment enzyme complex is recommended for the correction of solution is required per 1cm2 of treated surface). After that, apply ultrasound gel over Scar
- post-acne (see point 7); treatment enzyme complex.
- hypertrophic and keloid scars (see point 8) Recommended mode of introduction: intensity of radiation when applied to the body and
If side effects occur that are not described in section 12 of the annotation, consult your - stretch marks and atrophic scars (see point 9); limbs - 0.3 W/cm2, for the face and neck - 0.2 W/cm2.
dermatologist or cosmetologist. - complications after filler injections (see paragraph 10); Duration of procedure for one area: 2-3 minutes for a child, 3-5 minutes for an adult.
In the annotation, the terms "product," "Scar treatment enzyme complex," refer to a - Dupuytren's contracture (see paragraph 11). The total duration of the procedure on several areas must not exceed: 10 minutes for a
collagenase-based product in accordance with this Annotation Safety: absolutely safe, contains no fat base, no harmful and ballast for skin cell systems child, 20 minutes for an adult.
Color-coded: "Restrictions and Conditions of Use", "Practice and Recommendations" substances (emulsifiers, parabens, synthetic fragrances (parfum), SLS, formaldehydes, Frequency of procedures: daily, the allowed interval between the procedures should not
dyes, mineral oils (oil), silicones, GMOs, etc.). exceed 2 days.
Contents Course duration: 10-15 procedures.
Description of the drug and general conditions of use 2. What you should know before using the preparation Interval between courses: 10-14 days.
2. What you need to know before using the drug Do not use Scar treatment enzyme complex if you are allergic to the ingredients used in
3. Preparation for use this product (listed in section 14). 6. Method of application
4. How to use the preparation with electrophoresis Express test for allergic reactions to the product Before the procedure, dilute Scar treatment enzyme complex concentrate (see p.3).
5. How to use the preparation with phonophoresis Before use, apply the diluted preparation to the inner part of the elbow bend and wait 6-12 Apply the diluted preparation with clean hand on the clean dry skin over the whole area
6. Method of application hours. Normal reaction is no change of skin color or pinking, and no itching, rash or other (0,1ml of Scar treatment enzyme complex ensures solution per 1cm2 of treated surface).
7. Post-acne correction manifestations of discomfort. Bright red skin color, rash, itching indicates an allergic After applying the preparation cover the treated area by polyethylene film (if possible).
8. Hypertrophic and keloid scars correction reaction. Exposure time: from 30 minutes to 2 hours.
9. Stretch marks, atrophic scars and post-acne correction If the preparation gets into the eyes, it may sting, which is neutralized by flushing the eyes Frequency: twice a day.
10. Correction of complications after filler injections with water. Duration of the 1st course: 30-40 days.
11. Prevention of progression and recovery procedures after "open" surgery for Contact of the preparation with an open wound is safe. Duration of 2nd course: 30-40 days.
Dupuytren's contracture Pregnancy, lactation and menopause Interval between courses: 10-14 days.
12. Possible side effects Scar treatment enzyme complex contains active enzymes. No studies have been The number of procedures by application method is twice as much as by electrophoresis or
13. How to store the drug conducted and there are no results on the effect of the drug on the body of a child, so it is phonophoresis.
14. Packaging and additional information not recommended to use the preparation during pregnancy and breastfeeding.
1. Description of the preparation and general conditions of use It is not recommended for children to come into contact with the preparation or body parts 7. Post-acne correction
Scar treatment enzyme complex is an enzyme preparation of hydrobiont collagenase, that have been treated with the preparation. The main substrate for the effect is
which is a complex of collagenolytic proteases (collagenolytic protease complex with No restrictions for use during menopause. pathological collagen fibers in the
molecular masses of 36 (I) kDa, 36 (II) kDa, 36 (III) kDa and 28 kDa) and has pronounced Driving correction of post-acne. Scar
collagenolytic activity against pathological collagen of epidermal tissue. The preparation Scar treatment enzyme complex has no adverse effects on the body that make it difficult treatment enzyme complex provides
also contains enhenchangers (inorganic salts), which ensure the passage of bioactive to drive. complete or partial regression of the
components of the preparation through the transdermal barrier to the lower layers of the scar, its softening, reduction of the
epidermis. 3. Preparation for use height of the scar protrusion,
Mechanism of scar reduction The product is in powder form and requires dilution. reduction of local unpleasant
3.1 Dilution of the dry concentrate to obtain a 0.1% solution subjective sensations (itching,
3.1.1 The preparation is in the form of dry concentrate and requires dilution with sodium burning, painfulness), the difference
chloride (0.9% NaCl); in color between the scar and the
3.1.2 Take 10 ml of sodium chloride with a syringe and inject it into the vial with the surrounding tissues is erased, the
preparation (insert an additional needle into the vial with the preparation to release air); intense bright purple color of the
3.1.3 Shake the vial until the drug dissolves (a small precipitate is allowed). scar is discolored. Noninvasive
3.1.4 Take 1 ml of the diluted preparation and with the same syringe 9ml of sodium methods of introducing collagenases
chloride, shake the syringe (10ml syringe is recommended). into the scar tissue are
3.1.5 After completing steps 3.1.1-3.1.4 you get 0.1% solution of the preparation which is pathogenetically sound.
ready for use; Electrophoresis and phonophoresis with Scar treatment enzyme complex allow obtaining a
3.1.6 To prepare 0.05% solution 0.5 ml of the preparation is taken instead of 1 ml (see significant clinical result in a shorter period of time.
3.1.4). Scheme of correction of post-acne
Severity of skin lesions and clinical Phonophoresis Electrophoresis
4. How to use the preparation with electrophoresis manifestations with 0.05% Scar with 0.05% Scar
Only carbon electrodes are used for the procedure. The area of the electrode should treatment enzyme treatment enzyme
extend beyond the boundaries of the scar by at least 0.5 cm on each side. Anode-cathode complex solution complex solution
counter position according to classic electrophoresis techniques.
Macular (spotty) skin lesions - erythematous, 5-7 procedures is not used
Soak a pad of filter paper or gauze napkin with 0.1% (or 0.05%) solution of Scar treatment
hyper- or hypo-pigmented flat scars that do not
enzyme complex, apply on clean dry skin. The pad needs 0.1 ml of the preparation solution
change the topography of the skin, but affect its
per 1 cm2 of the pad. The pad should protrude around the perimeter of the electrode to
color
avoid burns. The electrode (anode) soaked in pure water should be placed on top. Only
use the positive electrode (anode) for injection! If necessary, secure the electrodes to the Mild skin lesions - mild atrophic or hypertrophic 7-10 procedures 5-7 procedures
body with plaster. scars, which are invisible at a distance of 50 cm
To calculate the required current with the electrode (anode) area, multiply the electrode or more, with hypertrophy of over 50%
(anode) area × by the corresponding current density value. The resulting value is set on Medium skin lesions - moderate atrophic or 2 courses of 10-12 2 courses of 10-12
the indicator of the device for electrophoresis. hypertrophic scars, clearly visible at 50 cm or procedures procedures
Injection mode for an adult: more; with skin tension, atrophic scars smooth
- current density not more than 0.1 mA/cm2 on the skin of the torso and extremities; out, hypertrophy over 50%
- current density not exceeding 0.05 mA/cm2 in the face and neck.
For children under 5 years of age in electrophoresis in the face and neck, the current Significant skin lesions - marked atrophic or 3 courses of 12-15 3 courses of 12-15
density should not exceed 0.01mA/cm2. hypertrophic scars, clearly visible at a distance procedures procedures
Duration of the procedure: of more than 50 cm; with skin tension, atrophic
- for adult 20-25 minutes; scars are not smoothed out, hypertrophy is more
- for children under 5 years of age - 10-15 minutes. than 50%.
Frequency of procedures: daily, the permissible interval between the procedures is not
more than 2 days. 8. Correction of hypertrophic and keloid scars
Duration of the 1st course: 10-15 procedures. Special conditions:
The duration of the second course: no more than 10 procedures. Use not earlier than 2-3 weeks
Interval between courses: 7-10 days. after granulation of the wound. Use
with caution for scars after removal
5. How to use the drug with phonophoresis (ultrasound) of malignant neoplasms of the skin
Contraindications for phonophoresis: and mucous membranes, only after
- acute infectious diseases and febrile conditions; consultation with an oncologist.
- period of exacerbation of cardiovascular and other severe somatic diseases; Scar treatment enzyme complex
Scar treatment enzyme complex has high collagenolytic activity, providing deep hydrolysis - systemic blood diseases; deeply hydrolyzes peptide bonds of
of collagen peptide bonds. Collagen hydrolysis occurs down to individual amino acids. The - general exhaustion; excess collagen of the scar tissue
preparation shows selective activity against molecules of pathological collagen with - malignant tumors; and destroys the 2 main
nodular and vortex packing characteristic of keloid and hypertrophic scars and is less - benign neoplasms; components of the scar tissue:
active against fibrils of native collagen characteristic of healthy tissue. Scar reduction - hypertensive disease III stage; pathological collagen and
occurs due to destruction of excess collagen. Also, the drug has a general proteolytic - acute atherosclerosis of cerebral vessels; hyaluronic acid. Treatment of
activity and the ability to hydrolyze polysaccharides, so there is a complex effect on all - acute dermatitis, skin lesions in the area of the scar. abnormal skin scars using
components of the scar tissue. - facial nerve palsy; physiological procedures with Scar
treatment enzyme complex has therapeutic efficacy.
Electrophoresis and phonophoresis with Scar treatment enzyme complex are effective
methods of introducing collagenolytic enzymes into the scar tissue. Under the influence of
electric current and ultrasound, diffusion of collagenolytic enzymes into deep areas of the
scar tissue is increased and the reduction of pathological collagen is accelerated.
Thanks to physiological procedures, the scars become paler, smaller in size, less dense
and more elastic, the itching decreases or stops, and the hydration of the scar tissue is
normalized. Successful experience of application of electrophoresis and phonophoresis
with complexjv collagenase for correction of hypertrophic and keloid scars allows to speak
about high efficiency of the preparation.
Scheme of correction of hypertrophic and keloid scars
Type and age of the scar Phonophoresis with Scar Electrophoresis with Scar
treatment enzyme treatment enzyme complex
Hypertrophic not more than 6 iscomplex
not usedsolution solution
10 procedures, 0.05%
months solution
Hypertrophic mature 2 courses of 10 procedures, 1-2 courses of 10 procedures,
0.05% solution 0.05% solution
Paraffin therapy for the hand
Keloid not more than 6 is not used 2-3 courses of 10-15 Paraffin therapy is an effective method of heat treatment with refined, fusible paraffin.
month procedures, 0.05% solution Paraffin warms tissues, thus increasing their temperature by 1-3°C. Paraffin treatments
Keloid mature 2 courses of phonophoresis for 10-15 procedures and 3-4 have anti-inflammatory, pain-relieving, relaxing, anti-spastic, wound-healing, restorative,
courses of electrophoresis for 10-15 procedures, 0.1% resolving effects and promote better penetration of collagenolytic proteases into the scar
solution. Phonophoresis courses should be alternated with tissue.
electrophoresis courses Duration of the procedure: 30-40 min.
Example of calculation of the required amount of preparation for one electrophoresis 1. For 1 course we will need 1-1.5 kg of medical paraffin.
procedure (for an adult): 2. Choose a clean plastic container with low sides, in which a brush can easily fit. Before
the procedure, lubricate the bottom and walls of the container with Vaseline oil.
Volume of solution

3. Wash your hands thoroughly

Current intensity
Anode area, cm2

on the indicator,

needed for one

procedure, ml

before the procedure.

solution, ml
Solution, %

Quantity of

4. Heat 500g of paraffin in a water

mA

Type of scar
bath to 60-65°C.
5. Pour the paraffin into the
prepared container and let it cool
down to 52-56°C.
Keloid not more than 100 10 10 200
0,05 6. Carefully dip a brush into the wax
6 months 200 20 20 for 5-10 seconds.
100 10 10 100 7. Carefully pull out the hand
Keloid mature 0,1 without abrupt movements and
200 20 20
wrap it with a towel or a
9. Correction of stretch marks, atrophic scars and post-acne handkerchief.
Phonophoresis and electrophoresis with Scar treatment enzyme complex is an effective 8. Remove paraffin from the hand
method of introducing the active components into the entire depth of striations (stretch after 30-40 min. and throw it away.
marks) and atrophic scars. As a result of the impact of the acoustic field (electric current) 9. The remains of cured wax from
is a deep tissue micromassage, increases the permeability of membranes, loosens the container can be used for the
connective tissue, increases the sensitivity of cells to the active components of the next treatment.
preparation. Thanks to physical procedures, the processes of remodulation of the
structure of striae and atrophic scars are accelerated, the framework of the dermis is
restored.
Scar treatment enzyme complex allows non-invasive destructuring of damaged collagen
fibers and stimulates without injection the synthesis of biopolymers of the derma 12. Possible side effects
framework, which guarantees the absence of micro-traumas and side effects such as Discontinue use and consult a dermatologist or cosmetologist if you suspect that an
inflammations, bruises, scars, post-traumatic pigment spots. allergic reaction has been triggered by use of the product (e.g., a rash).
Scheme of correction of stretch marks and atrophic scars Redness
Type and age of the scar Phonophoresis or electrophoresis with Skin redness is a possible and normal reaction during electrophoresis.
0.05% Scar treatment enzyme complex Dry skin
Young stretch marks and atrophic 2solution
courses of 6-10 procedures, 10 days break Electrophoresis dries the skin, therefore it is recommended to treat the corresponding skin
scars not more than 6 months between courses area with water or hydrogel after the procedure.
Reporting side effects
Old stretch marks and atrophic 2 courses of 12-20 procedures, 10 days break If you experience any side effects after using the product that are not described in the
scars between courses package leaflet, consult your dermatologist or cosmetic surgeon. You can also report the
side effects to the manufacturer microbioserum@gmail.com and/or the national health
Mixed post-acne, atrophy of more than 2-3 courses of 20 procedures, 10 days'
regulatory authority.
50 % break between courses
The product is manufactured in accordance with the TECHNICAL SPECIFICATIONS
"MULTI-COMPONENT COSMETICS FOR REPAIR OF SKIN CELL SYSTEMS"
10. Correction of complications after the introduction of fillers TS U 20.42.15-1816221886-001:2015.
The percentage of undesirable effects caused by the correction of cosmetic defects with National supervisory authority: Ministry of Health Protection of Ukraine.
biodegradable fillers is quite small and amounts to just 1-5% of cases according to different Reporting side effects will help make this drug safer and more effective.
sources. 95% of complications and side effects after fillers are due to errors in techniques
of injection, and only 5% of complications after fillers are associated with defects in the 13. How to store the drug
introduced material. Fibrosis in the injection site is manifested in the development of new Keep the preparation out of reach of children.
collagen fibers and connective tissue overgrowth with a large number of blood vessels, Shelf life of Collagenase-Ion in powder form at t 2÷8°C (refrigerator) - 12 months.
which is a natural reaction of the body to any foreign substance. Sometimes this Store diluted preparation in refrigerator at 2÷8°C for maximum 45 days.
overgrowth is excessive. Non-invasive, painless methods of introducing Scar treatment EXP date is indicated on the label.
enzyme complex through electrophoresis and phonophoresis provide powerful hydrolysis
of excessive pathological collagen, the volume of scar tissue is reduced, and the skin 14. Package contents and other information
surface is smoothed. Product composition
Scheme of correction of complications after the introduction of fillers Scar treatment enzyme complex contains 100 mg of collagenase enzyme, 50 mg of
Phonophoresis or electrophoresis with 0.05% Scar treatment enzyme complex keratinase enzyme. Also inorganic salts, micro and macro elements, normalizes
solution
5-7 procedures metabolism at the cellular level, provides osmotic action on human skin cells and transport
of active ingredients through the transepidermal barrier.
11. Prevention of progression and recovery procedures after "open" surgery for What is included in the package
Dupuytren's contracture Packaging: preparation in a bottle for injection.
The initial manifestations of Dupuytren's contracture are characterized by the appearance Color: white powder.
of dense knots, bands, and skin tightness in the palm of the hand due to the scarred The preparation is available only in the form of dry concentrate in a vial for injection,
degeneration of the palmar aponeurosis. Progression of the scarring process gradually without outer box and without labelling leaflet.
leads to the formation of limitation of extension of the fingers involved in the pathological Developer: Microbioserum.
process. The function of the hand is not limited or there are minor restrictions. To prevent Manufacturer: Microbioserum, address: 03067, Ukraine, Kiev, Tupikova str. 5/1, 20, e-mail:
further progression of the disease, as well as in the presence of contraindications to microbioserum@gmail.com, site: www.microbioserum-melliborub.com.
surgical treatment, complex physiotherapeutic treatment including paraffin applications and
electrophoresis or phonophoresis with Scar treatment enzyme complex is recommended.