Republic of the Philippines

Cebu Normal University

DRUG STUDY
Osmeña Blvd. Cebu City, 6000 Philippines
Patient’s Initials: GSD Date of Admission: 12/01/22 College of Nursing
Diagnosis: Malignant Spinal Cord Compression secondary to Renal Cell CA
Age: 49y/o Height: 163cmWeight.:
Center
65kg
of Excellence (COE) | Level IV Re-
Clinical Intervention: Palliative Care
Accredited (AACCUP)
Sex: Male Ward: VND Bed No.: 402D
TelephoneName
No.:of(032)
Physician: Dr. Ann Erieka D. Tanaka
254 4837
Email:
Drug Information Classification Mechanism of Action cn@cnu.edu.ph/secretary@cnunursing.org
Indication Contraindications Side Effects Nursing Responsibilities
Generic Name: Pharmacologic Pharmacodynamics Website:
or General www.cnu.edu.ph
Indication/s: (per system preferably) Before Drug Administration:
Piperacillin- Classification: Mechanism of Action: Treatment
_______
of
● Hypersensitivity to
penicillins, beta- ● Check the doctor’s order
Tazobactam Extended Piperacillin: Binds to moderate to severe CNS:
spectrum bacterial cell wall bacterial infections, lactams,
● Seizures (higher ● Obtain a history before initiating
penicillins membrane, including: cephalosporins, or
Trade Name:
causing cell death. tazobactam (cross doses) therapy to determine previous use
RiteMED ● community of and reactions to penicillins or
Spectrum is extended sensitivity may
Piperacillin- ● Confusion cephalosporins. Persons with a
compared acquired/ occur).
Tazobactam
with other penicillins. nosocomial negative history of penicillin
● Dizziness sensitivity may still have an
Tazobactam: Inhibits beta- pneumonia Use cautiously in:
Minimum Dose: allergic response.
lactamase, an enzyme that ● intra-abdominal, ● Headache
4.5g can destroy penicillins. ● Renal impairment
pelvic, skin, and ● Assess patient for infection (vital
(CCr <40mL/min) ● Insomnia
Maximum Dose: skin structure signs; appearance of wound,
Pharmacokinetics: ● Sodium Restriction
18g daily infections ● Lethargy sputum, urine, and stool; WBC) at
Absorption: beginning of and during therapy.
Piperacillin is well absorbed ● Infections from ● Critically ill patients GI:
Patient’s Dose: (80%) from IM sites. beta-lactamase– ● Obtain specimens for culture and
3.375g ● Pregnant and ● Clostridium difficile-
Distribution: Widely producing sensitivity prior to initiating
Route: distributed. Enters CSF well strains of S. associated diarrhea therapy. First dose may be given
 Republic of the Philippines
IV Therapeutic only when meninges are Cebu Normal University
aureus lactating women (CDAD) before receiving results.
Classification: inflamed. Crosses the Osmeña Blvd. Cebu City, 6000 Philippines
● H. influenzae ● Diarrhea
Frequency: Anti-infectives placenta and enters breast College of Nursing
milk in low concentrations.Centerinfection
During Drug Administration:
q6 hrs of Excellence (COE) | Level IV Re- ● Constipation
Metabolism Accredited (AACCUP)
and ● Bacteroides ● Administr using the 10 rights of

Availability/
Excretion: Telephone No.: (032) 254 4837 ● drug-induced medication administration
Form:
Piperacillin (68%) and ● PsAg Email: hepatitis ● After diluting 5mL 0.9% NaCl for
Injection powder:
tazobactam (80%) arecn@cnu.edu.ph/secretary@cnunursing.org
2.25g, 3.375g,
Website: www.cnu.edu.ph
mostly excreted unchanged ● Acinetobacter ● nausea injection, shake well; further dilute

4.5g
by the kidneys. _______ in at least 50 mL compatible IV
● Klebsiella ● vomiting sol and run int inf over at least 30
Elimination half-life:
Adults: 0.7– 1.2 hr; Children pneumoniae minutes.
Premix Ready to After Drug Administration:
6 mo– 12 yr: 0.7– 0.9 hr; ● E. coli. GU:
Use:
Infants 2– 5 mo: 1.4 hr. ● Observe patient for signs and
2.25g (50mL), ● interstitial nephritis
3.375g (50mL), symptoms of anaphylaxis (rash,
4.5g (100mL)> Patient’s Indication: ● renal failure pruritus, laryngeal edema,
wheezing). Discontinue the drug
Indicated for and notify health care
Contents: treatment of Hemat: professional immediately if these
Piperacillin Na 4 g, pulmonary infection
● bleeding occur. Keep epinephrine, an
tazobactam Na
antihistamine, and resuscitation
500 mg
● leukopenia equipment close by in the event
of an anaphylactic reaction.
● thrombocytopenia ● Monitor bowel function. Diarrhea,
● neutropenia abdominal cramping, fever, and
bloody stools should be reported
to health care professional
 Republic of the Philippines
Cebu Normal University Local: promptly as a sign of Clostridium
Osmeña Blvd. Cebu City, 6000 Philippines difficile-associated diarrhea
● pain
College of Nursing (CDAD). May begin up to several
week following cessation of
Center of Excellence (COE) | Level IV Re- ● phlebitis at IV site
Accredited (AACCUP) therapy.
Telephone No.: (032) 254 4837 ● Assess for skin reactions (rash,
Email: Derm:
fever, edema, mucosal erosions
cn@cnu.edu.ph/secretary@cnunursing.org ● Acute Generalized or ulcerations, red or inflamed
Website: www.cnu.edu.ph eyes).
_______ exanthematous
● Monitor patient with mild to
● Pustulosis
moderate rash for progression. If
● drug reaction with rash becomes severe or systemic
symptoms occur, discontinue
eosinophilia and piperacillin/tazobactam.
systemic symptoms
(dress) ● Monitor for signs and symptoms
of DRESS (fever, rash,
● stevens-johnson
lymphadenopathy, and/or facial
syndrome swelling, associated with
● toxic epidermal involvement of other organ
systems (hepatitis, nephritis,
necrolysis
hematologic abnormalities,
● rashes myocarditis, myositis) during
therapy. May resemble an acute
● Urticaria viral infection. Eosinophilia is
often present. Discontinue
therapy if signs occur.
 Republic of the Philippines
Cebu Normal University ● Evaluate renal and hepatic
Osmeña Blvd. Cebu City, 6000 Philippines
College of Nursing function, CBC, serum potassium,
and bleeding times prior to and
Center of Excellence (COE) | Level IV Re-
Accredited (AACCUP) routinely during therapy
Telephone No.: (032) 254 4837
Email:
References cn@cnu.edu.ph/secretary@cnunursing.org
Website: www.cnu.edu.ph
_______
Kizior, R. J., Hodgson Keith J, Hodgson Barbara B, & Witmer, J. B. (2016). Saunders nursing drug handbook. Elsevier.
‌ eglin, J. H., Sanoski, C. A., & Vallerand, A. H. (2015). Davis’s Drug Guide for Nurses (14th ed.). Philadelphia, PA: F.A. Davis Company.
D
Hodgson, K. J., Kizior, R. J. (2019). Saunders Nursing Drug Handbook 2019. Elsevier.
Nursing 2008 drug handbook. (2008). Philadelphia, PA: Lippincott Williams &amp; Wilkins.