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Plant PM code
o Product / ltem type Alu Foil ALPHA CHYMOTRYPSINE
c6 pnAH { Version number
Country VIETNAM
* SANOFI * Plant D9
Operator Le Dinh Khoa
vtEr NAM lnitiated date A1_04-r 1-2016
Dimension Alu lzl4mm (blister 42x96mm)
fe Fonts
Size 5pt
Colours

56lo SX, HD: ddp nditr€n vi ! erNroNe+ssc InANToNE 296sc

Approval oftext date: Signature:

Final approval date: _ Signature:

--
PVDC 146mm

AIu 144mm

5mm 4mm
(

PHIN s^noH vlET NA { CONG TY

iig* Iqg*
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 GMID finished good code :

Plant PM code
Product / ltem type Box ALPHA CHYMOTRYPSINE
Version number
Country VIETNAM
Plant D9
Operator Le Dinh Khoa
lnitiated date A4_05-03-201 8
Dimension 46x22x101mm
Fonts
Y 100

Size : 5.5 pt PANTONE 4T3 C

Colours PANTONE 445 C

PANTONE 5u1O C

Approval oftext date: Signature:

Final approval date: Signature:

CONG
c6 PnAt't
SANOFI
VIET NAM
Vtng kh6n9 in mlu va khong phi mlng

fk nu6. te AonZ prescription oly medicine

va
!
.n,"ffiIil?GHOAY'
2 vl x 10
2 blisters x 5E

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ngam dudi lrroi
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STORE BELOW 30"C, PROTECT FROtvt MOISTURE AND LIGHT !:

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Chymokypsine (Alphachymotrypsine)
2l microkatals
Exeipienls q.s one tablet.
Chymolrypsin (Alphachymotrypsin)
2l microkatals
Td duOc vara dri 1 vEn n6n.
\/
lndicalions. administration. Chi dinh, cSch dnng, chdng chi dinh
contra.indications and olher vi cdc th6ng tin khdc: xem trong ld
inlormationr See package insed, hu6ng dan si d$ng thudc kam theo.
 CONG TY
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SANOFI
vtE T NAM

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sANoFt \? Pa,(

!{ t0 5U &tdr lto:

83 mm

sO L0 _NcAy sAN xuAT_ HAN Dt NG rN DUot DAYTUYP

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GMID finished good code
Plant PM code
Product / ltem type Tube ALPHA CHYMOTRYPSIN E
T
Version number
Country VIETNAM
Plant D9
Operator Le Dinh Khoa
lnitiated date A4_08-03-201 8
Dimension 83x56mm
Fonts
Size 5.5 pt Yellow
Colours
! nerroHevoc PANTONE 4I3 C

I
",
79 M:66 I PANTONE 485 C

Approval oftext date: Signature:

Final approval date: Signature:

/
 l.5mm

ililllililt 7mm

CONG TY
c6 pnAtl
SANOFI
VIET NAM
*dfficxoAY"
34\34x70

R nuftkoddl R Tho&l6ddl
D{ xr t6m tay cu tr6 em PKiilim6tmltnc rtAxx nrlvcomposrtox: ks(iptim fily ffiI(im
Keep out ol the Enh ot children
(Alph&hyrctrypsin)
*#fficxoAf
Chymotrypsin
09< ki hu&g dan sO dung rn d<
l4ri ding/ Rerd c.refully the
prtage inged before u*
-dfficH T5
2I ml.rokatals
dffi vir. dt I vi6n n6n
Erclpl€nts qsp I tablet

Ir€u chudry' Sp€cilkationr:

TCCS/ Manufacture/i. o( Chl4nh,dch ding.
xem
dlnh vl cr< th6rg tln
tryE
<hdng chl
ktac
td hudng d5n s& dung
thu6c kam theo.
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sDr,/ Reg.No.:
H!c
lndiotlon, admlnlitEtiorL |]60 1 rdh iln
6Dg 10
&rof1 contcindl(atimr & other ,qoaINt $bH.b
infomatlms: re package insert.

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sANoFtufr
cd dHAH
NAM
qu{ 30t, r6nh rm
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30PC, protect from -f
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tldns ho& alm dd h6
Manufa<tund bla
SANOFI VIETNAM
qd mlc or ruutqul ell*d air&Ro.|
SHAREHOLDING COMPANY
Lot l-&Z D8 Strel Saigm HH<h Parh
Long fhanh My Ward, District 9.
Ho Chl Minh City, Metnam
SANOFI\i SANOFITi SANOFI\i

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Et-J Vtng kh6n9 in mau vt kh6n9 phi mlng

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7mm
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GMID finished good code

Plant PM code
Product / ltem type Box ALPHA CHYMOTRYPSINE
Version number
Country VIETNAM
Plant D9
Operator Le Dinh Khoa
lnitiated date A5_05-03-201 8
Dimension 34x34 x 70 mm
Fonts
Size : 5.5 pt Yellow

Colours f rexroneroc PANTONE 4I3 C

I I PANTONE 485 C
",79M:66

Approval of text date: Signature: ,/

Final approval date: Signature:
 ng theo don thuiSc
co
s
P
o
-t,
LPHACHYMOTRYPSIN E CHOAW
SANOFI *
VIE T NAM Chymotrypsin 21 microkatals
Vi6n n6n
DE EM
Dgc KY Ht oNG sr} DUNG TRUOC KHt DUNG.
OAr.r
THONG BAo NGAY cHo BAc si HoAc Duo. c si NHIrNG pHAN Orue co HArcAp pHA! KHrsu
DUNG rHU6C.

THANH PHAN CONG THOC THU6C:

M6ivi6n chOa:
Thdrnh phin hoqt chdt: Chymotrypsin hay alphachymotrypsin... 21 microkatals
Thinh phAn t6 duqc: tinh diu bac hi, magnesi stearat, tinh bgt mi, tluong vd 1 vi6n.
DANG BAO CHE:
Vi6n n6n trdn, tr5ng d6n tring ngdr.
cxlolNn:
Di6u tri ph0 nd sau chSn thuong, ph6u thuQt, b6ng.
UEU DUNG VA cAcH DUNG:
Nguoi lon:
Duong u6ng:
U6ng mOt lin 2 vi6n, 3 hoic 4 lAn trong ngiry, n6n u6ng vdi nhi6u nudc (it nhet 8 oz tuong duong 240
ml) nhim girip gia ting hoqt tinh men. U6ng kh6ng nhai.
Ngam du0i lu0i:
4 cl6n 6 vi6n chia tt6u ra trong ngdry. DA thu6c tan tu tu dudi lu0i.
T16 em: Hien kh6ng co dir lieu vO lidu dUng cria chymotrypsin cho tr6 em.
cH6NG cHiolNH:
- Di Ong vdi c6c thdnh phAn c0a thu6c.
- Kh6ng s0 dr;ng chymotrypsin tr6n bQnh nhin gidm alpha-1 antitrypsin. Luu f, benh nhin bi bQnh ph6i $
',"o'l
tic ngh6n man tinh (COPD), clic biet ld khi ph6 th0ng, v?r hgich0ng than hu lir nh6m benh nhin co nguy
co gi6m alpha-1 antitrypsin. .4
CANH BAO VA THaN TR9NG KHr DUNG THU6C:
2233 4
- Chymotrypsin dugc dung nqp t6t va fnOng giy t6c dung phu il6ng k5.
- Nh0ng bQnh nhdn kh6ng n6n didu tri c6c thu6c dang men bao gdm: ngudi b! 16i loan d6ng m6u di o CONG TY
truydn nhu hem_ophilia (ch0ng m6u loing kh6 tl6ng), r6i loan dOng mdu, dirng thu6c kh6ng tl6ng, s5p cr) c6 pnAn
phdi trii qua phiu thuQt, di Ong vdi protein, phq nO co thai hofc clang nu6i con be ng s0a me, lo6t da SANOFI
su DUNG THUoC CHO PHU No CO THAI VA CHO GON B0: VIET NAIV
Kh6ng n6n srl dr;ng chymotrypsin cho phU nO dang mang thaivi nu6i con bing s0a me.
I re
Atttt xUONG cuA THUOc l-En xxA NANG LArxE, vAN HANH uAv naoc:
HiQn chua c6 b6o c6o vd khi ning c0a thu6c inh hu0ng tr6n khi ning l6ixe vi vQn hdnh mdy m6c.
Tr,roNG TAC, TUONG KY CUA THU6G:
- Chymotrypsin thuong cluqc dung pn6i nqp v0i c5c thu5c dqng men kh6c it6 gia ting hieu qud di6u tri.
ThOm viro-d6, ch6 dO 5n cdn O6i noac srl dung vitamin va b6 suhg mu5i khoang duEc khuy6n cdo d6 gia
tdng hoqt tinh chymotrypsin.
- MQt vii loai hat nhu h?t dfu jojoba (& B5c M!), dQu ndnh co ch0a nhi6u loqi protein 0c ch6 hoat tinh
chymotrypsin. Tuy nhi6n, nh0ng protein niry c6 th6 bi bet hoat khi ilun s6i.

rl2

/
- Kh6ng n6n sr] dung chymotrypsin vdi acetylcystein, m6t thu5c dirng O6 tam tan dim dudng h6 hdp, vd
kh6ng n6n ph6i hEp chymotrypsin vdi thu6c kh6ng tl6ng vi ldm gia tlng hi6u tuc cfia chring.
TAc DUNG KHONG MoNG MUON cUR rxu6c:
- R6i loan ti6u h6a: hi6m gip (ADR < 1/ 1.OOO) c6c trudng hop r6t luOivd d6 d IuOi, dAy hoi, nfng bung,
ti6u chdy, t6o b6n hoic budn n6n.
86o c5o vd cic tic dgng kh6ng mong mu5n:
NOu ban c6 b6t c0 tic dung pJrU nio, hdy b5o cho bic si hoic dugc si, k6 cd nhirng t6c dqng phu chua
duqc liet kong td hu0ng d5n srit dung thu6c ndy. Khi bio c5o cdc t6c dr,rng phr,r, ban se giUp cung c5p
kO
th6ng tin vd OO an toin c0a thu6c ndy.
Xrb tri tic dgng kh6ng mong mu6n:
-n6i toan ti6u hoa: ngung hoic giim li6u thu6c.
Th6ng b6o ngay cho bic s! ho{c duEc s! nh0ng phdn Ong co hai gip phdi khi s0 dung thu6c.
aUA UEU vA GAcH xlr rni:
H.i€n kh6ng c6 th6ng tin vd tri6u chung c6 th6 yAy ra khi dr)ng qu6 li6u chymotrypsin. N6u nghi ngd qud
li6u, hiy li6n he ngay v0i bdc si hoic phdng cdp cr1u.
Dac riNH DUgc Lr/c HQC:
Ch6ng phir nd do vi6m dqng men.
Chymotrypsin ld mQt enzym ph6n gidi protein, duqc di6u ch6 bang c6ch hoAt h6a chymotrypsinogen
chi6t xu6t tu tuy bd. Chymotrypsin tl{c bi€t c5t cic li6n t<Ct cnu6i cdc acid amin thom (phenylalamin,
tyrosin, tryptophan, methionin, norleucin, vd norvalin). Chymotrypsin c0ng di duqc st} dung d6 di6u tri
ph0 n6 do vi6m, sau ch6n thuong, sau phSu thu?t, hoic sau b6ng.
Nhu mOt thu6c kh6ng vi6m, chymotrypsin vi cdc men ti6u protein kh6c ngin chin t6n thuong mO trong
qui trinh vi6m vi hinh thdnh sgi to nuy6t lfiOrin). Men ti6u protein tham gia vdo qud trinh phin hriy sqi to
huy6t ttugc gqi li qu6 trinh ti6u soi huy6t. SEi to nuy6t ninn thirnh l0p rdo bao quanh v0ng vi6m giy tic
ngh6n m?ch m6u vd mach bach huy6t d5n d6n hiQn tuqng phO nA t4i virng vi€m. Sqi to huySt c0ng c6
th6 ph6t tri6n thirnh cdc cuc m6u d6ng.
oac riNH Dr/gc DQNG HQC:
Chymotrypsin ld mQt men ti6u h6a phin huf c6c protein (cdn ggi ld men ti6u protein hay protease).
Trong co th6 con ngudi, chymotrypsin dugc sdn xuAt tU nhi6n _bdi tuy6n tqy. Tuy nhi€n, chymotrypsin tu
ngu6n g6c ilOng vQt c0ng dugc srl dr,rng nhu mOt dang men b6 sung nhim cdi thi€n suc kh6e, ti6u hoi
II

vir h6 trq di6u tri nhi6u bQnh lf khdc nhau.

Ngodi chymotrypsin, cdc men ti6u protein kh6c dugc ti6t bdituy6n tuy bao gdm trypsin vd
carboxypeptidase.
\
*
QUY CACH DONG GOI: o
HQp 2 vix 10 vi6n. HQp 1 6ng x 40 vi6n. o o
-o
DtEu KIFN BAo auAN
*
Bdo qudn 0 nhiet clO kh6ng qui 300C, trinh 5m vir 6nh s6ng
HAN DUNG
18 thdng k6 tu ngdy sdn xu5t.
nEU CHUAN CHAT LuPONG COA THUOG
TCCS
co sO sAtt xuAr THUoG
CONG TY CO PHAN SANOFIVIET NAM
LO l-8-2, Dudng D8, Khu C6ng nghe cao, Phuong Long Thanh M!, QuQn 9, Tp.HCM, Viet Nam

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