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Antimicrobials Mechanisms of Action
Antimicrobials Mechanisms of Action
Learning Goals
Meningitis
● Antibiotic combination
○ Broaden the antibacterial spectrum for empirical therapy or the treatment of
polymicrobial infections
○ Prevent the emergence of resistant organism during therapy
○ Achieve a synergistic killing effect
● Antibiotic synergism
○ Combination of 2 antibiotics that together have enhanced bactericidal activity
○ I.e. Penicillin (inhibits cell wall synthesis) + Gentamicin (inhibits protein synthesis)