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Mueller et al.

Cardiac Imaging • Original Research


Cardiac CTA After Bypass
Surgery
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Cardiac CT Angiography After


Coronary Bypass Surgery:
Prevalence of Incidental Findings
Jeffrey Mueller1,2 OBJECTIVE. Cardiac CT angiography (CTA) is commonly performed after coronary ar-
Jean Jeudy1 tery bypass grafting surgery (CABG) to assess graft patency, but the images also include parts
Robert Poston3 of the lungs, abdomen, and mediastinum. The purpose of our study was to retrospectively as-
Charles S. White1 sess the prevalence of unsuspected disease identified on cardiac CTA examinations after CABG
and to determine their potential clinical significance.
Mueller J, Jeudy J, Poston R, White CS MATERIALS AND METHODS. CTA was performed postoperatively in 259 patients
(mean, 5.2 days), and 40 patients underwent a follow-up CT scan (mean, 12.7 months). Cardiac
CTA was acquired using a 16-MDCT scanner with ECG-gating and bolus timing with a small
field of view centered on the heart. Two thoracic radiologists assessed each examination in con-
sensus. The prevalence of graft disease and incidental findings (cardiac and noncardiac) was
established. The electronic medical record was reviewed. A finding was judged potentially sig-
nificant if a therapeutic intervention or radiologic follow-up was deemed advisable on the basis
of the cardiac CTA. Bypass graft occlusions were analyzed separately.
RESULTS. In the immediate postoperative period, 51 patients (19.7%) had at least one un-
suspected, potentially significant finding. Twenty-four patients (9.3%) had a cardiac finding
such as a ventricular pseudoaneurysm, ventricular perfusion deficit, or intracardiac thrombus,
and 34 patients (13.1%) had a noncardiac finding including pulmonary embolism, lung cancer,
or pneumonia. At least one bypass graft was occluded in 17 patients (6.6%) in the immediate
postoperative period. In the later postoperative period, seven patients (17.5%) had a potentially
significant unsuspected finding. Four patients (10.0%) had at least one graft occlusion.
CONCLUSION. Cardiac CTA after CABG revealed a high prevalence of unsuspected
cardiac and noncardiac findings with potential clinical significance. Interpreters of these stud-
ies should be familiar with the spectrum of these abnormalities.

CG-gated cardiac CT, initially cium scoring examinations without IV con-

Keywords: bypass, cardiac imaging, CT coronary


arteriography, lung diseases E with electron beam CT (EBCT)
and more recently with MDCT, is
increasingly being used to evaluate
trast with EBCT [1–3]. However, limited in-
formation exists regarding the prevalence of
clinically significant incidental unsuspected
DOI:10.2214/AJR.06.0736 the coronary arteries and to provide an assess- findings in patients undergoing CTA [3–7].
ment of noncoronary cardiac disease. Cardiac The rate of incidental findings with MDCT
Received June 1, 2006; accepted after revision CT angiography (CTA) examinations are typi- may be higher because thinner reconstruc-
March 19, 2007.
cally acquired with a small field of view fo- tions are used and IV contrast material is ad-
1Department of Diagnostic Radiology, University of cused on the heart, but portions of the lungs, ministered. In addition, previous incidental
Maryland School of Medicine, 22 S Greene St., Baltimore, pleura, chest wall, mediastinum, thoracic skel- MDCT cardiac CTA studies have focused
MD 21201. Address correspondence to C. S. White. eton, and upper abdomen are often included as on patients suspected of having coronary ar-
2Present address: Department
part of the examination. Although a wider field tery disease. To our knowledge, no informa-
of Radiology, Allegheny
General Hospital, Pittsburgh, PA.
of view may be reconstructed from the raw tion currently exists on the rate of incidental
data to assess for additional thoracic findings, findings in patients with known ischemic
3Division ofCardiac Surgery, Department of Surgery, these images are not typically used to evaluate heart disease or following cardiac surgery.
University of Maryland School of Medicine, Baltimore, MD. the coronary arteries and bypass grafts. We retrospectively evaluated the frequency
AJR 2007; 189:414–419
A substantial rate of incidental findings of unsuspected cardiac and noncardiac dis-
necessitating therapeutic intervention or ease in patients who underwent cardiac CTA
0361–803X/07/1892–414
further radiologic evaluation has been found for routine assessment of coronary artery
© American Roentgen Ray Society in patients undergoing coronary artery cal- bypass graft (CABG) patency.

414 AJR:189, August 2007


Cardiac CTA After Bypass Surgery

Materials and Methods structed and used for primary analysis. Other hypertension was designated if the main pulmonary
Patients phases were reconstructed in some patients but artery diameter was greater than 3.1 cm. A small
Patients who receive CABG at the University were not used for this analysis. The primary data pericardial effusion was judged to be present if peri-
of Maryland Medical Center often undergo car- were also reconstructed using curved planar recon- cardial fluid did not completely encircle the heart. A
diac CTA to assess for graft patency as part of their structions along the long axis of the bypass grafts. moderate or large pericardial effusion was denoted
routine postoperative care. From our radiology in- Wider field of view images (x, y direction) were not by fluid completely encircling the heart.
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formation system, we identified all individuals reconstructed from the raw data. Graft abnormalities were analyzed separately.
who underwent CTA after CABG surgery between All incidental findings and graft abnormalities were
October 2002 and March 2006. In the immediate Image Interpretation and Review reviewed independently by two radiologists (the
postoperative period, 259 patients (mean age, 63.7 Each examination was interpreted at the time of primary author and a second thoracic radiologist) to
years; age range, 37–89 years; 73.4% men, 26.6% scanning by a thoracic radiologist. Axial CT im- substantiate their presence and a final decision was
women) underwent a routine contrast-enhanced ages at 75% of the R-R interval and curved planar based on consensus.
cardiac CTA examination. Surgical techniques in- postprocessed images were predominantly used for
cluded both off-pump (178 patients, 68.7%) and image interpretation. Additional images retrospec- Statistical Analysis
on-pump (69 patients, 26.6%) cardiac bypass and tively reconstructed at 10 phases of the cardiac cy- Significant findings were divided into cardiac
minimally invasive (six patients, 2.3%) or hybrid cor- cle were also available if needed. The reviewer pro- and noncardiac disease. The prevalence of each
onary bypass grafting (six patients, 2.3%). On aver- vided a qualitative assessment of the overall quality finding was calculated. The prevalence of bypass
age, examinations were performed on postoperative of the scan and reviewed all images on soft-tissue, graft occlusion was determined.
day 5.2 (range, 1–38). Of the original group, a subset mediastinal, lung, and bone windows. The patency
of 40 patients underwent a routine follow-up cardiac of each graft was assessed. The grafts were graded Results
CTA an average of 12.7 months (range, 2–22 months) as occluded or nonoccluded. When radial grafts Fifty-one patients (19.7%) were found to
after CABG as part of a research protocol for bypass were used, spasm was defined as a patent graft with have at least one potentially significant finding
graft patency. Patients who underwent scanning for diffuse narrowing. Relevant cardiac and noncardiac requiring therapeutic intervention or further ra-
nonroutine cardiopulmonary disease were excluded. findings were described in the final report. diologic evaluation. Among these, 24 patients
An institutional review board exemption was granted The primary author, a fellow in thoracic radiol- (9.3%) had at least one cardiac finding and 34
for this study, and the study was performed in ogy with 6 months of cardiac CTA experience, ret- patients (13.1%) had at least one noncardiac
compliance with Health Insurance Portability and rospectively assessed each finalized report and re- finding. Seven patients (2.3%) had both a car-
Accountability Act (HIPAA) regulations. viewed the electronic medical record of each diac and noncardiac finding. Five patients had
patient to determine the clinical relevance of each two noncardiac findings (1.9%). Three patients
Image Acquisition finding. A data sheet was generated that included had two cardiac findings (1.2%).
CT angiography was acquired using a 16- the patient’s age, sex, postoperative day, status of The most common cardiac findings were a
MDCT scanner (MX8000 IDT, Philips Medical the bypass grafts, and cardiac and noncardiac find- moderate or large pericardial effusion (Fig. 2)
Systems). For each patient, retrospective ECG- ings. A finding was defined as potentially signifi- (eight patients, 3.1%), intracardiac thrombus
gated images were obtained through the entire cant if a therapeutic intervention was required or if (Figs. 3 and 4) (six patients, 2.3%), and sub-
chest during a single breath-hold beginning at the further radiologic evaluation was deemed neces- stantial paracardiac or mediastinal hemorrhage
inferior margin of the heart and extending to the top sary by the interpreting radiologist. Cardiac disease (six patients, 2.3%). Among noncardiac abnor-
of the lung apices (Fig. 1). Patients were advised to was documented if the abnormality was paracar- malities, pulmonary nodule (nine patients,
exhale slowly if they could not maintain breath- diac, pericardial, or within the heart itself. Noncar- 3.5%), pneumonia (six patients, 2.3%), tra-
holding throughout the examination. The scanning diac was classified as pulmonary, mediastinal, cheal or lobar mucous plugging (six patients,
protocol included collimation of 0.75 mm × 16 pleural, or involving the upper abdomen. Common 2.3%), and pulmonary embolism (Fig. 5) (five
with section thickness of 1 mm. The scanning tech- and expected postsurgical findings (e.g., small patients, 1.9%) were most frequent (Table 1).
nique was 140 kVp and 350–500 mAs. The typical pleural or pericardial effusions, pneumomediasti- On the basis of the CT interpretation, 15 pa-
field of view was 250 mm with a matrix of num, mild pulmonary edema, etc.) were not in- tients (5.8%) had a documented clinical inter-
512 × 512. A pitch of 0.2–0.3 was used with a scan- cluded. Findings of minimal clinical significance vention and 12 patients (4.6%) had a radiologic
ner rotation time of 0.42 second. Iodinated contrast (e.g., goiter, hiatal hernia, etc.) and known disease follow-up. Two patients had both a clinical in-
material (120–150 mL) was injected through an 18- (e.g., cardiomegaly, emphysema, etc.) based on in- tervention and a radiologic follow-up. The re-
to 20-gauge angiocatheter into an antecubital vein formation in the electronic medical record (history maining 26 patients (10.0%) were lost to fol-
at 3–4 mL/s. Automated bolus timing was per- and physical, operative note, discharge summary, low-up or did not have further intervention to
formed using a threshold value of 150 H and a re- echocardiogram, clinic notes, previous radiology our best knowledge. Further interventions in-
gion of interest was placed over the ascending studies, etc.) were noted, but not included in the fi- cluded repeat cardiac surgery (three patients,
aorta. Beta blockade was typically provided as part nal analysis. Repeat findings on the immediate and 1.2%), hospital readmission (one patient,
of routine postoperative care. For accurate image late postoperative examinations were excluded 0.4%), insertion of a pericardial drainage cath-
acquisition, sinus rhythm was required, with a from consideration on the second CT scan. eter (one patient, 0.4%), lung carcinoma (one
mean heart rate less than 100 beats per minute. Some significant findings were defined according patient, 0.4%), anticoagulation (five patients,
Average scanning time was 30–40 seconds. All to following guidelines. A native coronary artery an- 1.9%), bronchoscopy for a large mucous plug
images were reconstructed with a small field of eurysm was defined as a lumen diameter at least 1.5 (one patient, 0.4%), blood transfusion (two pa-
view centered on the heart. In each patient, a phase times the size (> 6 mm) of a normal adjacent coro- tients, 0.8%), and antibiotic treatment for
obtained at 75% of the R-R interval was recon- nary artery segment (usually 2–4 mm). Pulmonary pneumonia (three patients, 1.2%).

AJR:189, August 2007 415


Mueller et al.
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Fig. 1—Scout topogram shows typical field of view Fig. 2—45-year-old man who underwent cardiac CT Fig. 3—73-year-old man who underwent routine
used for each examination. To include entire course of angiography 6 days after coronary bypass grafting cardiac CT angiography 7 days after coronary bypass
internal mammary arteries, craniocaudad (z-axis) field surgery. Axial CT image shows anterior ventricular grafting surgery. Axial CT image shows thrombus in left
of view is more cephalad than typical cardiac pseudoaneurysm (white arrow) and large atrial appendage (arrow). Intraoperative
CT angiography. hemopericardium (open arrow). Patient had good transesophageal echocardiogram showed no
recovery after surgery. intracardiac thrombus (not shown).

therapy. The decision to transfuse two pa-


tients was based on the combination of the
CT interpretations and the low hemoglobin
levels. One of the patients who had large mu-
cous plug underwent bronchoscopy for aspi-
ration of the plug. We presume the remain-
ing patients with mucous plugging received
pulmonary toilet, but clinical documentation
is not available for confirmation.
Of the 40 patients who underwent a routine
follow-up cardiac CTA in the late postopera-
tive period (mean, 12.7 months), seven pa-
tients (17.5%) had an incidental and unsus-
pected finding. Among these, three patients
(7.5%) had a cardiac finding and four patients
(10%) had a noncardiac finding. These find-
Fig. 4—67-year-old man who underwent coronary Fig. 5—63-year-old symptomatic man who underwent
ings included a new left subclavian artery routine cardiac CT angiography 2 days after coronary
artery bypass grafting surgery after inferior myocardial
infarction. Axial CT image from routine cardiac CT thrombus, pulmonary edema, apical left ven- artery bypass grafting surgery. Axial CT image shows
angiography 7 days after surgery shows unsuspected tricular perfusion defect, moderate pericar- saddle pulmonary embolism (arrow).
left ventricular thrombus (arrowhead). dial effusion, new central venous obstruction,
and moderate-sized pleural effusion. All
seven patients were treated conservatively. Discussion
Of the nine pulmonary nodules that were With respect to bypass graft assessment, Our study of a rather large cohort of pa-
found, one patient underwent pulmonary one or more bypass grafts were occluded in tients suggests a frequency of unsuspected
consultation, PET, and lung biopsy with a 17 patients (6.6%) in the immediate postoper- and potentially significant findings of approx-
histologic diagnosis of lung carcinoma ative period and in four patients (10.0%) in imately 20% in patients who undergo cardiac
(Fig. 6). Three patients received follow-up the late postoperative period. All of the oc- CTA both immediately and remotely after
chest CT revealing nodule stability. A fourth cluded grafts (Fig. 7) were saphenous vein CABG. Several studies have assessed the fre-
patient is scheduled for CT follow-up. Of the grafts. One patient had two saphenous vein quency of incidental findings in the context of
two adrenal masses, both patients received grafts occlude in the immediate period. None various types of cardiac-focused CT exami-
follow-up abdominal CT. One mass was di- of the internal mammary artery grafts oc- nations [1–7].
agnosed as a lipid-rich adrenal adenoma. cluded. Spasm was a frequent finding with ra- A modest body of literature has been pub-
The second adrenal mass remained indeter- dial artery grafts, although none of these lished concerning incidental findings on un-
minate on follow-up abdominal CT. The pa- grafts were occluded. Graft patency was not enhanced EBCT scans obtained for coronary
tient has not undergone additional workup or confirmed with catheter angiography. calcium scoring [1–3]. Horton et al. [1] re-

416 AJR:189, August 2007


Cardiac CTA After Bypass Surgery

TABLE 1: Significant and Unexpected Immediate Postoperative Findingsa


Patients Percent Imaging Follow-Up Treatment
Incidental noncardiac findings
Pulmonary nodule 9 3.5 Four patients (follow-up chest CT) One patient (lung carcinoma)
Pneumonia 6 2.3 Three patients (antibiotics)
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Large mucous plug 6 2.3 One bronchoscopy


Pulmonary embolism 5 1.9 Three patients (anticoagulation)
Aortic ulcer or aneurysm 3 1.2 Three patients (follow-up chest CT)
Adrenal mass 2 0.8 Two patients (follow-up abdominal CT)
Moderate pleural effusion 2 0.8 One patient (follow-up chest CT)
Sternal dehiscence 1 0.4 Reoperation
Mediastinitis 1 0.4 One patient (follow-up chest CT)
Sarcoidosis 1 0.4
Pulmonary hypertension 1 0.4
Moderate-sized pneumothorax 1 0.4
Incidental cardiac findings
Moderate-to-large pericardial effusion 8 3.1 One patient (pericardial drain); one patient
(reoperation); one patient (hospital
readmission)
Large mediastinal hematoma 6 2.3 One patient (follow-up chest CT) One patient (reoperation); two patients
(blood transfusion)
Left ventricular thrombus 4 1.5 One patient (anticoagulation)
Left ventricular perfusion deficit 3 1.2
Left ventricular pseudoaneurysm 2 0.8 One patient (reoperation)
Left atrial thrombus 2 0.8 One patient (anticoagulation)
Right ventricular compression, pectus excavatum 1 0.4
Native coronary artery aneurysm 1 0.4
Apical left ventricular aneurysm 1 0.4
a Average postoperative time, 5.2 days.

ported that 7.8% of patients undergoing coro- both incidental cardiac and noncardiac disease, has known ischemic heart disease. Therefore,
nary calcium scoring required additional they determined that 9.3% of patients required the discovery of complicating conditions,
workup for noncardiac disease. In a later further radiologic investigation, and specific such as intracardiac thrombi, myocardial per-
study, Schragin et al. [2] found 4.2% of pa- therapy was initiated in 22 patients (1.2%). Ma- fusion deficits, and ventricular aneurysms,
tients required CT follow-up and 20.5% of lignant disease was detected in three patients. from significant coronary artery disease is not
examinations had at least one noncardiac The rate of incidental disease was higher surprising. In addition, large mediastinal or
finding, including one patient where the inci- with the use of MDCT for coronary CTA. A paracardiac hemorrhage was included in the
dental finding was the cause of death. These recently published study by Haller et al. [4] cardiac category, another condition that occa-
studies differ from the current study in that showed that 4.8% of patients undergoing car- sionally occurs after coronary bypass.
they were performed with relatively thick sec- diac CTA with a small field of view had a ma- The results of this investigation suggest
tions (3 mm) and without the use of IV con- jor noncardiac finding and 19.9% of patients that the rate of incidental disease detected on
trast material, precluding evaluation of car- had a minor noncardiac finding. In two recent cardiac CTA examinations after major cardio-
diovascular and mediastinal structures. In abstracts by Shafique et al. [5] and Onuma et vascular surgery in the inpatient or critical
addition, we studied postoperative patients al. [6], the rate of significant noncardiac find- care setting is higher than in cardiac CTA ex-
after cardiovascular surgery, whereas many of ings requiring further investigation or treat- aminations typically performed in the outpa-
the patients studied with EBCT were outpa- ment on contrast enhanced cardiac CTA ex- tient setting. Several issues may account for
tients. This may explain the lower rate of ab- aminations was 16% in both studies. A third this discrepancy. One consideration is that the
normalities with potential clinical impact de- abstract also showed a high prevalence (44%) patient cohort in our study is presumably a
tected in the EBCT studies. of significant or potentially significant non- higher risk group than the majority of patients
The prevalence of incidental findings was coronary disease [7]. The prevalence of non- who undergo cardiac CTA as outpatients. In
found to be higher with the use of IV contrast. cardiac findings in those studies is similar to an effort to evaluate the internal mammary ar-
Hunold et al. [3] examined patients who under- this evaluation. However, the rate of inciden- teries, the CABG CTA protocol extends more
went a cardiac EBCT examination for calcium tal cardiac findings in this study was much cephalic than a typical cardiac CTA examina-
scoring or coronary angiography. Combining higher. Nearly every coronary bypass patient tion. Including the superior thorax with a

AJR:189, August 2007 417


Mueller et al.

Nearly all graft failures involved saphenous


vein grafts and none occurred with internal
mammary grafts. Although bypass graft oc-
clusion was not routinely confirmed on cath-
eter angiography, the rates of graft failure are
concordant with the published literature [8]. It
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has been proposed that subacute premature


saphenous vein graft failures (i.e., the addi-
tional grafts that occluded after the early post-
operative period) are due to neointimal hyper-
plasia, which predominately affects venous
but not arterial grafts [9, 10].
This study has important clinical ramifi-
cations. Bypass graft patency is a common
indication for cardiac CTA, particularly
among patients with recurrent symptoms af-
Fig. 6—A 1.1-cm spiculated left upper lobe pulmonary Fig. 7—56-year-old woman with unsuspected ter CABG. To our knowledge, this is the first
nodule, (arrows) was discovered in 76-year-old man thrombosed aortocoronary saphenous vein graft study examining the rate of incidental find-
shortly after coronary bypass. Percutaneous lung (arrow) 5 days after coronary artery bypass
biopsy revealed carcinoma. grafting procedure. ings on cardiac CTA examinations per-
formed primarily on postoperative patients
or those with known ischemic heart disease.
Previous incidental studies have focused on
outpatients or individuals with suspected
coronary artery disease [1–7]. As a result,
the rate of incidental cardiac disease was
higher (9.3%). This highlights the need to
evaluate extracoronary cardiac structures as
well as the noncardiac anatomy on every
cardiac CTA examination. In addition, car-
diac CTA examinations performed after ma-
jor cardiovascular surgery have the potential
to detect treatable cardiac and noncardiac
complications in a more timely fashion.
This was evident from our investigation be-
cause we found a number of treatable con-
ditions that were not clinically suspected at
A B the time. Treatable disease included pulmo-
nary embolism (Fig. 5), pneumonia, cardiac
Fig. 8—63-year-old asymptomatic man who underwent cardiac CT angiography 3 days after coronary bypass
grafting surgery.
pseudoaneurysms (Figs. 2 and 8), intracar-
A, Axial CT image shows left ventricular aneurysm (arrow). diac thrombi (Figs. 3 and 4), and mediasti-
B, Oblique multiplanar reformatted image in vertical long axis projection confirms inferior ventricular nal and pericardial hemorrhage.
pseudoaneurysm (arrow). LA = left atrium, LV = left ventricle. This study has several important limita-
tions. Bias was introduced because of the
longer z-axis area of coverage allows addi- setting, we excluded known disease typically retrospective design of the study. We did not
tional abnormalities to be detected (Fig. 1). found on preoperative pulmonary function review studies without a reported unsus-
One mitigating factor that may have paradox- testing or echocardiography (i.e., emphysema pected finding because there would have
ically lowered the prevalence of certain ab- or cardiomegaly), abnormalities of minimal been no opportunity to act on these findings
normalities is that common postoperative ab- significance (i.e., goiter and hiatal hernia), even if they were significant. In addition,
normalities such as atelectasis and effusions and expected postoperative conditions (i.e., long-term clinical and imaging follow-up
obscured significant abnormalities. pulmonary edema). were not available in many patients with a
Another consideration is that the definition We chose to analyze bypass grafts sepa- significant finding. We determined thera-
of what constitutes a clinically significant rately because their assessment was the indi- peutic intervention on the basis of clinical
finding varies among different studies. Most cation for the CTA, and thus a graft occlusion information in the electronic medical record,
studies, including this one, define “signifi- could not truly be called incidental. At least which usually includes the operative note,
cant” or “potentially significant” if imaging one failed graft occurred in 6.6% of patients echocardiogram, cardiac catherization, dis-
follow-up or a therapeutic intervention was in the immediate postoperative period and charge summary, and radiology reports.
advised. However, to maintain as much clini- 10.0% of patients in the late postoperative pe- However, this system does not include every
cal relevance as possible in a postoperative riod, indicating a significant attrition rate. follow-up surgical, cardiology or primary

418 AJR:189, August 2007


Cardiac CTA After Bypass Surgery

care clinic note. Therefore, determining if a CTA should be cognizant of both cardiac and giography. AJR 2005; 184 [American Roentgen
therapeutic intervention or specialty consult noncardiac findings commonly present in pa- Ray Society 105th Annual Meeting Abstract Book
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basis of the imaging interpretation alone was 8. Fitzgibbon GM, Kafka HP, Leach AJ, Keon WJ,
sometimes difficult. Thus, we chose the term Hooper GD, Burton JR. Coronary bypass graft fate
“potentially significant.” Other published References and patient outcome: angiographic follow-up of
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ond. Because our patient population recently scanning. J Thorac Imaging 2004; 19:82–86 in vein grafts subjected to arterial pressure: a
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AJR:189, August 2007 419

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